Sample records for gian piero zarri

  1. Gian-Carlos Rota and Combinatorial Math. (United States)

    Kolata, Gina Bari


    Presents the first of a series of occasional articles about mathematics as seen through the eyes of its prominent scholars. In an interview with Gian-Carlos Rota of the Massachusetts Institute of Technology he discusses how combinatorial mathematics began as a field and its future. (HM)

  2. Piero Castiglioni - praktilise ilu looja / Karin Paulus

    Index Scriptorium Estoniae

    Paulus, Karin, 1975-


    Itaalia disaineritest Castiglioni'dest, pikemalt Piero Castiglionist (sünd. 1944), kes külastas 2005. aasta märtsis Eestit. Loetletud tema tähtsamad tööd. Kommenteerivad sisearhitekt Hannes Praks, sisearhitekt Juta Lember, valgusdisainer Tarmo Luisk ja EKA professor Toivo Raidmets

  3. Stigmatising Faith? Differing Modes of Sanctification in Gian-Carlo ...

    African Journals Online (AJOL)

    Although best known for his Christmas opera Amahl and the Night Visitors (which is often asserted to be the most frequently performed music drama of the twentieth century), Gian-Carlo Menotti composed other operas in which he explored the confrontation between religious faith and practice on the one hand and ...

  4. A CERN physicist receives the Gian Carlo Wick Medal

    CERN Multimedia


    T.D. Lee, Chairman of the Gian Carlo Wick Medal selection committee, André Martin, the 2007 recipient, and Antonino Zichichi, President of the World Federation of Scientists (WFS)(Copyright : WFS) The 2007 Gian Carlo Wick Gold Medal was presented to the CERN theoretical physicist André Martin in Erice (Italy) on 20 August. The prize is awarded each year by the WFS (World Federation of Scientists), whose president is Professor Antonino Zichichi, to a theoretical physicist for his outstanding contributions to particle physics. The selection committee is composed of eminent physicists and is chaired by the Nobel Physics Prize Laureate, T.D. Lee. André Martin was awarded the Medal in recognition of his work on the total cross-section for interactions between two particles and his contributions to the understanding of heavy quark-antiquark (or quarkonium) systems. In 1965, André Martin established a theoretical basis for the so-call...

  5. Piero della Francesca's Sky in The Dream of Constantine (United States)

    Valerio, V.


    The recent restoration of the frescoes by Piero della Francesca in the Church of San Francesco in Arezzo has made to appear on the background of the scene of Constantine's dream a number of stars. They are clearly painted with the intention to illustrate a sort of "natural" sky. In 2001 Anna Maria Maetzke recognized in a group of stars the constellation of the Ursa Minor, but so far no further study has been carried on to find any relation between the painted and the true sky. In this paper I show the existence of more constellations in the fresco, which are hardly detectable due to the mirror representation of the starry sky. Such a mirror image, as the Universe was seen from the outside, has a Greek origin and this kind of representation was introduced in Western Europe not only in celestial globes but also in star maps. This discovery leads to consider that Piero had at his disposal either a globe or a map which he reproduced on the fresco. My hypothesis is that a star map might be supplied to Piero by the astronomer Regiomontanus who was in Italy since 1461 following the Cardinal Bessarion in his journey from Wien to Rome. In 1463, Cardinal Bessarion was named papal legate to Venice and in July of the same year he leaved Rome together with Regiomontanus to reach Ferrara and Venice. The road to Venice crossed Umbria nearby Sansepolcro, Piero's birthplace not far from Arezzo. The trip took more than two weeks due to a stop before crossing the Apennines because the plague in Ferrara. Bessarion and Regiomontanus might have met Piero who was painting the cycle of frescoes in Arezzo and supplied him with a star map. Unfortunately, due to the lack of the horizon and any right line in the scene it is not possible to detect the latitude of the place corresponding to the painted sky.

  6. Research Method and Phenomenological Pedagogy. Reflections from Piero Bertolini

    Directory of Open Access Journals (Sweden)

    Luca Ghirotto


    Full Text Available Inspired by Husserlian phenomenology, Piero Bertolini defined the phenomenological pedagogy and education as a scientific discipline (Bertolini, 2005. This project remains an undetermined one as there is still room for defining its research methods. This article intends to propose a contribution to the discussion of research methodology, in line with the assumptions of Piero Bertolini (1988 phenomenological pedagogy. In particular, starting from the definition of phenomenological pedagogy and education, it aims to answer the question: what are the research strategies through which to build a viable and rigorous educational knowledge, able to grasp the personal transformation and development in a context of inter-subjectivity? Accordingly, I shall discuss data collection and analysis strategies.

  7. Piero Gobetti and the Politics of Liberal Revolution


    Martin, James


    Piero Gobetti was an astonishing figure. A radical liberal and fierce critic of Italian politics in the years after World War I, he was fascinated by the workers' struggles in his native Turin and by Gramsci's vision of a factory-based democracy. Gobetti proposed liberalism as an emancipatory theory grounded in social conflicts. "Revolutionary liberalism," as he called it, guided his opposition to Fascism and, following his untimely death at twenty-five, inspired key figures in the Italian Re...

  8. Explaining Italian Underdevelopment. The Liberal Revolution of Piero Gobetti

    Directory of Open Access Journals (Sweden)

    Gonzalo Varela Petito


    Full Text Available This article presents to the readers in Latin America the thought of the Italian liberal writer and politician Piero Gobetti (Torino 1900–Paris 1926 who was a close friend of Antonio Gramsci and one of the main intellectual influences on the work of the marxist peruvian thinker José Carlos Mariátegui. His most relevant book, La Rivoluzione Libérale, was translated into Spanish only recently but —as Mariátegui understood— some of Gobetti's ideas are very relevant to an analysis of Latin American socialformations. His very original "movement oriented" liberalism was influenced by the Russian revolution as well as by philosophers like Georges Sorel, Gaetano Mosca, Benedetto Croce and Henri Bergson.Gobetti's major concern in politics was to promote the emergence of a new ruling class. For a better comprehension of his thought, Gobetti's ideas are here compared with those of Gramsci and Mariátegui.

  9. Two Critics of Marginalist Theory: Piero Sraffa and John Maynard Keynes


    Kurz, Heinz D.


    The paper discusses the contributions of two major critics of marginalist theory: John Maynard Keynes and Piero Sraffa. While Keynes and his followers directed their attention and energy first and foremost to a criticism of Say's law, Sraffa and his followers did so with respect to marginal productivity theory. However, as the paper shows, Sraffa's criticism implies also a rejection of Say's law. The main focus of the paper is the route by means of which Sraffa arrived at his analysis and to ...

  10. Entrevista com Mathieu Dosse, Gian Luigi de Rosa e Michael Kegler

    Directory of Open Access Journals (Sweden)

    Andréia Guerini


    Full Text Available O conjunto das três entrevistas que seguem aborda a mesma temática, isto é, aspectos de tradução/adaptação em geral e da tradução do romance Estive em Lisboa e lembrei de você de Luiz Ruffato em particular. O romance de Ruffato foi escrito em 2009, editado em Portugal (Quetzal, 2010 e traduzido para diferentes línguas, como italiano (La Nuova Frontiera, 2011, espanhol (Eterna Cadencia, 2011, francês (Chandeigne, 2015, alemão (Assoziation A, 2016 e, nos próximos meses será publicado em finlandês (Into. O livro foi adaptado para o cinema em 2015, pelo cineasta português José Barahona, sendo exibido em festivais nacionais e internacionais. As entrevistas abaixo foram feitas com os tradutores Gian Luigi De Rosa, Mathieu Dosse e Michael Kegler em 2016. Gian Luigi De Rosa (Itália/1969-- possui doutorado em “Culture e Istituzioni dei paesi di lingue iberiche in età moderna e contemporanea” e é professor de português na Universidade do Salento, em Lecce. É autor de livros e ensaios sobre língua e linguística portuguesa, literatura portuguesa e brasileira e tradução audiovisual e intersemiótica. É também responsável pela elaboração das legendas em italiano do filme Estive em Lisboa e lembrei de você. Mathieu Dosse (Brasil/1978-- é formado pela Université Paris 8, onde estudou Teoria da Tradução. Traduziu para o francês Graciliano Ramos, Luiz Ruffato e João Guimarães Rosa. Michael Kegler (Alemanha/1967-- estudou literatura brasileira e portuguesa na universidade de Frankfurt, sem concluir o curso. Trabalhou como livreiro no Centro do Livro de Língua Portuguesa, antes de se tornar tradutor literário. Traduziu para o alemão José Eduardo Agualusa, Moacyr Scliar, Luiz Ruffato, entre outros autores. Em julho de 2016, junto com Ruffato, recebeu o prêmio literário Hermann Hesse na Alemanha, pela qualidade da obra publicada em conjunto com a sua tradução.

  11. PIERO ontology for analysis of biochemical transformations: effective implementation of reaction information in the IUBMB enzyme list. (United States)

    Kotera, Masaaki; Nishimura, Yosuke; Nakagawa, Zen-ichi; Muto, Ai; Moriya, Yuki; Okamoto, Shinobu; Kawashima, Shuichi; Katayama, Toshiaki; Tokimatsu, Toshiaki; Kanehisa, Minoru; Goto, Susumu


    Genomics is faced with the issue of many partially annotated putative enzyme-encoding genes for which activities have not yet been verified, while metabolomics is faced with the issue of many putative enzyme reactions for which full equations have not been verified. Knowledge of enzymes has been collected by IUBMB, and has been made public as the Enzyme List. To date, however, the terminology of the Enzyme List has not been assessed comprehensively by bioinformatics studies. Instead, most of the bioinformatics studies simply use the identifiers of the enzymes, i.e. the Enzyme Commission (EC) numbers. We investigated the actual usage of terminology throughout the Enzyme List, and demonstrated that the partial characteristics of reactions cannot be retrieved by simply using EC numbers. Thus, we developed a novel ontology, named PIERO, for annotating biochemical transformations as follows. First, the terminology describing enzymatic reactions was retrieved from the Enzyme List, and was grouped into those related to overall reactions and biochemical transformations. Consequently, these terms were mapped onto the actual transformations taken from enzymatic reaction equations. This ontology was linked to Gene Ontology (GO) and EC numbers, allowing the extraction of common partial reaction characteristics from given sets of orthologous genes and the elucidation of possible enzymes from the given transformations. Further future development of the PIERO ontology should enhance the Enzyme List to promote the integration of genomics and metabolomics.

  12. Algunos problemas de interpretación en la teoría de precios de producción de Piero Sraffa

    Directory of Open Access Journals (Sweden)

    Guillén Romo Hector


    Full Text Available Aunque con el término "escuela neo-ricardiana" o "escuela de Cambridge" algunas veces se designa a las contribuciones de Joan Robinson, Nicholas Kaldor, Luigi Pasínetti y algunos otros á la teoría del crecimiento, en este ensayo nos referiremos casi exclusivamente a la teoría neo-ricardíana de los precios, tal y como ha sido elaborada por Piero Sraffa. Los fundamentos metodológicos de la escuela neo-ricardiana
    pueden ser encontrados en las obras de V. K. Dimitriev y L. Bortkiewicz, autores de finales del Siglo XIX e inicios del XX. La importancia de estos autores se ha visto particularmente incrementada en los últimos años, tras la publicación de la obra de Sraffa. La escuela neo-ricardiana puede ser analizada desde varios puntos de vista según que se consideren sus vínculos con la teoría marxista del valor o con la teoría neoclásica, ya sea en su versión vulgar (Jevons, Menger, Marshall o en su versión del equilibrio económico general (Arrow, Hahn, Malinvaud.

  13. A comparison of Percutaneous femoral access in Endovascular Repair versus Open femoral access (PiERO): study protocol for a randomized controlled trial. (United States)

    Vierhout, Bastiaan P; Saleem, Ben R; Ott, Alewijn; van Dijl, Jan Maarten; de Kempenaer, Ties D van Andringa; Pierie, Maurice E N; Bottema, Jan T; Zeebregts, Clark J


    Access for endovascular repair of abdominal aortic aneurysms (EVAR) is obtained through surgical cutdown or percutaneously. The only devices suitable for percutaneous closure of the 20 French arteriotomies of the common femoral artery (CFA) are the Prostar(™) and Proglide(™) devices (Abbott Vascular). Positive effects of these devices seem to consist of a lower infection rate, and shorter operation time and hospital stay. This conclusion was published in previous reports comparing techniques in patients in two different groups (cohort or randomized). Access techniques were never compared in one and the same patient; this research simplifies comparison because patient characteristics will be similar in both groups. Percutaneous access of the CFA is compared to surgical cutdown in a single patient; in EVAR surgery, access is necessary in both groins in each patient. Randomization is performed on the introduction site of the larger main device of the endoprosthesis. The contralateral device of the endoprosthesis is smaller. When we use this type of randomization, both groups will contain a similar number of main and contralateral devices. Preoperative nose cultures and perineal cultures are obtained, to compare colonization with postoperative wound cultures (in case of a surgical site infection). Furthermore, patient comfort will be considered, using VAS-scores (Visual analog scale). Punch biopsies of the groin will be harvested to retrospectively compare skin of patients who suffered a surgical site infection (SSI) to patients who did not have an SSI. The PiERO trial is a multicenter randomized controlled clinical trial designed to show the consequences of using percutaneous access in EVAR surgery and focuses on the occurrence of surgical site infections. NTR4257 10 November 2013, NL44578.042.13.

  14. Development of Reference Data Set (RDS) for LOBI-MOD2 Integral Test Facility- IAEA Fellowship Training at Nuclear Research Group of San Piero A Grado (GRNSPG), University of PISA, Italy

    International Nuclear Information System (INIS)

    Mohd Rizal Mamat


    Deterministic Safety Analysis (DSA) is one of the mandatory requirements conducted for Nuclear Power Plant licensing process in order to ensure compliance with relevant regulatory acceptance criteria. DSA is a technique whereby a set of conservative deterministic rules and requirements are applied for the design and operation of facilities or activities. Computer codes are normally used to assist in performing all required analysis under DSA. In order to ensure a comprehensive analysis, the conduct of DSA should follow a systematic approach. One of the methodologies proposed is the Standardised and Consolidated Reference Experimental (and Calculated) Database (SCRED) developed by University of Pisa which describes the whole processes or steps involved in the preparation of complete database for system thermal-hydraulic code applications for facilities or plants. Under this methodology, the use of Reference Data Set (RDS) as a pre-requisite reference document for developing input nodalization for system thermal-hydraulics code simulation has been proposed. This paper describes the experience of having undergone 2 months of IAEA Fellowship training at Nuclear Research Group of San Piero A Grado (GRNSPG) in University of PISA, Italy and the application of RDS and its effectiveness. Two RDS documents have been developed for an Integral Test Facility of LOBI-MOD2 facility and Test A1-83, 10% small cold leg break LOCA (Loss of Coolant Accident). (author)

  15. Stuxnet and Cyber-Warfare (2/2)

    CERN Multimedia

    CERN. Geneva


    The first part of the lecture is devoted to the description of the Stuxnet worm, the first cyber-weapon whose existence has been made public, discovered in 2010 and targeting a specific industrial control system; the worm is responsible for the damaging of many centrifuges at an uranium enrichment facility, with the goal of sabotaging Iran's nuclear program. In the second part, the main features of cyber-warfare in conflict and pre-conflict activities will be discussed and compared to the conventional warfare domains, with also a general view at the international political debate on this topic.   Check the web site, an organisation that seeks a world free of nuclear weapons and other weapons of mass destruction. The lecturer invites comments via email to NB! All Academic Training lectures are recorded and are publicly available. There is no live webcast.

  16. Fundamentals of Silicene, Authors: Guzmán-Verri Gian G., Lok C. Lew Yan Voon and Willatzen Morten

    DEFF Research Database (Denmark)

    Guzman-Verri, Gian G.; Voon, Lok C. Lew Yan; Willatzen, Morten


    Silicene1 is a single atomic layer of silicon (Si) much like graphene, the first example of an elemental twodimensional (2D) nanomaterial whose study led to the 2010 Nobel Prize in Physics.2 Until 2010 or so, the only known crystalline form of elemental silicon was the one with the so-called diam......Silicene1 is a single atomic layer of silicon (Si) much like graphene, the first example of an elemental twodimensional (2D) nanomaterial whose study led to the 2010 Nobel Prize in Physics.2 Until 2010 or so, the only known crystalline form of elemental silicon was the one with the so...... might make fabrication much more of an industrial reality. We will concentrate this tutorial on the properties of a single freestanding silicene sheet. Freestanding means that the silicene sheet is not chemically or physically bonded to any other material. The feat with graphene was the ability to peel...

  17. Muusikamaailm : Hooaja algus Kuninglikus Ooperis. Gian Carlo Menotti Helsingis. Messiaeni ooper heliplaadil. Salzburgi festivali ette Ruzicka / Priit Kuusk

    Index Scriptorium Estoniae

    Kuusk, Priit, 1938-


    Londoni Royal Opera House avati 1. dets. galaõhtuga pärast 2 aastat kestnud ümberehitusi. Seoses oma ooperi "Konsul" uuslavastusega Soome Rahvusooperis viibis Helsingis C. G. Menotti. O. Messiaeni ainus ooper "Püha Franciscus Assisist" jõudis heliplaadile. Salzburgi festivali kunstiliseks juhiks aastast 2001 valiti P. Ruzicka

  18. [Review of:] Piero De Risi, Dizionario della Qualità : 900 termini ed espressioni del linguaggio della Qualità. Milano : Il Sole 24 Ore, 2001, p. 613


    Baldazzi, Anna


    The Quality Dictionary copes with techiques and principles of total quality management as the interdisciplinary instrument of thematic areas and disciplinary fields configuring in the evolving area of: quality, management, marketing, production, statistics, planning, applied statistics, certification, organization, laws etc. The documentalist is forced to his own role re­engineering, more integrated at a productive and communicative social level. The dictionary systematizes “a common language...

  19. Academic Training Lectures | Stuxnet and Cyber-Warfare | 13-14 January 2016

    CERN Multimedia


    Please note that the next series of Academic Training Lectures will take place on 13 and 14 January 2016. The lectures will be given by Gian Piero Siroli (Università e INFN, Bologna (IT))   Stuxnet and Cyber-Warfare (1/2)​ on Wednesday, 13 January from 11 a.m. to 12 p.m. Stuxnet and Cyber-Warfare (2/2) on Thursday, 14 January from 11 a.m. to 12 p.m. at CERN, Council Chamber (503-1-001)  Description: The first part of the lecture is devoted to the description of the Stuxnet worm, the first cyber-weapon whose existence has been made public, discovered in 2010 and targeting a specific industrial control system; the worm is responsible for the damaging of many centrifuges at an uranium enrichment facility, with the goal of sabotaging Iran&...

  20. 34th UIT Heat Transfer Conference 2016

    International Nuclear Information System (INIS)


    renewed every three years. President, vice-President and secretary cannot be appointed for the same chair more than twice on end. UIT 2016 Steering committee Auditors Vincenzo Naso, President Mario De Salve Giuseppe Vella, Vice-President Marco Spiga Sara Rainieri, Secretary Luca Tagliafico Gian Piero Celata Davide Del Col Paolo Di Marco Alfonso Niro Past-Presidents Past-Secretaries Enrico Lorenzini Sandro Salvigni (First President and Founder) Piero Vigni † Sergio Faggiani † Gian Piero Celata Claudio Pisoni † Paolo Di Marco Gian Piero Celata Distinguished members Honorary members Gaetano Alfano † Arthur E Bergles † Vittorio Betta Michael W Collins † Maurizio Cumo Marino Di Marzo Giovanni Del Tin Frank P Incropera Giovanni De Comelli † Antonio C M Sousa Sergio Faggiani † Enrico Lorenzini Elio Oliveri Claudio Pisoni † Sandro Salvigni Giorgio Sotgia Scientific committee of the 34th UIT heat transfer conference Stefano Piva – Chair - Università degli Studi di Ferrara, Italy Giovanni Sebastiano Barozzi – Università degli Studi di Modena e Reggio Emilia, Italy Gian Paolo Beretta – Università degli Studi di Brescia, Italy Gian Piero Celata – Centro Ricerche ENEA Casaccia, Roma, Italy Michele Ciofalo – Università degli Studi di Palermo, Italy Mario De Salve – Politecnico di Torino, Italy Paolo Di Marco – Università di Pisa, Italy Marco Filippi – Politecnico di Torino, Italy Marco Fossa - Università di Genova, Italy Giovanni Latini – Università Politecnica delle Marche, Italy Enrico Lorenzini – Università degli Studi di Bologna, Italy Rita Mastrullo – Università degli Studi di Napoli Federico II, Italy Oronzio Manca – Seconda Università degli Studi di Napoli, Italy Vincenzo Naso – Università degli Studi di Napoli Federico II, Italy Alfonso Niro – Politecnico di Milano, Italy Enrico Nobile – Università degli Studi di Trieste, Italy Carlo Nonino – Università degli Studi di Udine, Italy Giorgio Pagliarini – Universit

  1. From CERN to Entrepreneurship: we don't know what we don't know

    CERN Document Server

    CERN. Geneva


    Piero Zucchelli is founder and CEO of Andrew Alliance, a company specialising in novel liquid handling robots designed to enhance the reproducibility and efficiency of the pipetting process. Before founding Andrew Alliance, Piero was CTO of SpinX Technologies for 8 years and prior to that a staff member at CERN.    

  2. Attitudes and Awareness Regarding Hepatitis B and Hepatitis C ...

    African Journals Online (AJOL)

    in many cases hepatitis B and C can lead to permanent liver ... Department of Public Health Dentistry, Gian Sagar Dental College and Hospital, 1Department of Oral Surgery, Gian ... training among HCWs to prevent the spread of hepatitis B virus and hepatitis C virus. ..... primary care physicians following the Department of.

  3. Source model for the Copahue volcano magma plumbing system constrained by InSAR surface deformation observations


    Paul Lundgren; M. Nikkhoo; Sergey V. Samsonov; Pietro Milillo; Fernando Gil-Cruz; Jonathan Lazo


    Tar files for each of the InSAR time series (interferograms used in the GIAnT time series computation as well as the input files and outputs from using GIAnT). GIAnT is an open source InSAR time series code developed at Caltech. The UAVSAR_*.tgz files contain the interferograms from the UAVSAR airborne system that were used in the analysis. The actual model input files require some additional down sampling using resamptool.m a Matlab code developed by Prof. R. Lohman, Cornell Univ.

  4. music in town: the musical shells of calvino and vladislavić

    African Journals Online (AJOL)


    Artists Calvino collaborated with are Sergio Liberovici, Piero Santi, Mario Peragallo, Bruno. Gillet and Adam ..... idea of space make up the theoretical framework which contains a composition for solo .... Einaudi, 201-220. De Benedictis, A.I..

  5. Vzácná florentská rytina z Regionálního muzea v Žatci. Středověký rukopis Meffertovy postily žateckého Regionálního muzea s unikátní rytinou florentské provenience

    Czech Academy of Sciences Publication Activity Database

    Petr, Stanislav


    Roč. 6, č. 0 (2016), , s. 18-24, 134-137 ISSN 2464-5273 Institutional support: RVO:67985921 Keywords : Piero Baldini, Florence * engraving * Regional Museum in Žatec, Czech Republic Subject RIV: AB - History

  6. Vot eto - stul, na njom sidjat / Niina Ratshinskaja

    Index Scriptorium Estoniae

    Ratshinskaja, Niina


    Toolidisaini ajaloost. Austria meistri Michail Tonet'i nn. viini toolist, Alvar Aalto taburetist, Le Corbusier' disainitud toolist, itaallaste Piero Gatti, Cesare Paolini ja Franco Teodoro kott-toolist, Philippe Starcki 1990. a. disainitud toolist

  7. Sidjatshaja tsivilizatsija / Nina Ratshinskaja

    Index Scriptorium Estoniae

    Ratshinskaja, Nina


    Toolidisaini ajaloost. Austria meistri Michail Tonet'i nn. viini toolist, Alvar Aalto taburetist, Le Corbusier' disainitud toolist, itaallaste Piero Gatti, Cesare Paolini ja Franco Teodoro kott-toolist, Philippe Starcki 1990. a. leiutatud toolist

  8. An inevitable end? The collapse of the Lombard kingdom facing the Franks and the papacy

    Directory of Open Access Journals (Sweden)

    Stefano Gasparri


    Full Text Available According to the Italian historiography, from Alessandro Manzoni (1822 to the two major Italian historians who studied the Lombards at the middle of the twentieth century, Gian Piero Bognetti and Ottorino Bertolini, the Lombards remained always separated from the Roman population, of which the pope was the natural leader; the Lombards, too, became very late Catholics, in time, though, to experience the "drama" of having to fight against the pope, whose supreme spiritual authority the Lombards themselves at that point recognized. Consequently, the fall of the independent kingdom by the hands of the Franks would be logical and inevitable. This is an old and outdated position: the end of the independent Lombard kingdom wasn’t inevitable. At the time of the Frankish conquest, the kingdom was politically solid inward, in economic growth and very dynamic outward. During the reigns of Liutprand, Ratchis and Aistulf (712-757, the kingdom exercised its hegemony over the whole Italy. In this period no strong elements of internal weakness emerged. Therefore, the defeat of 774 was substantially caused by external factors, ie the alliance between the Franks and the papacy. However, the attitude of the popes against the Lombard kingdom was not always hostile. Things changed only with Stephen II, because of two simultaneous events occurring in 751: the royal anointing of Pepin in the Frankish kingdom and the conquest of the Exarchate by Aistulf. Italian political balance broke and caused the decisive rapprochement between Rome and the Franks. But there were still many uncertainties, as proved, for example, by Charlemagne’s marriage with a daughter of Desiderius. Carloman’s death in 771 and, the following year, the election of the new pope Adrian I caused the repudiation of the Lombard bride by Charlemagne, his descent into Italy in 773, and the capture of Pavia the year after: Desiderius was exiled in France and Charlemagne became rex Langobardorum. The

  9. Muusika / Priit Kuusk

    Index Scriptorium Estoniae

    Kuusk, Priit, 1938-


    8. okt. avab Eesti Kontsert pidulikult vastvalminud Jõhvi kontserdimaja. Estonia kammersaalis esietenduvad Gian Carlo Menotti ooperid "Meedium" ja "Telefon". 1. X toimus Toronto Eesti Majas uue kontsertklaveri Estonia sisseõnnistamise galakontsert. Klassikaraadios algab uus saatesari "Mõttehelin"

  10. 78 FR 52601 - Culturally Significant Object Imported for Exhibition; Determinations: “Visiting Masterpiece... (United States)


    ... Treasure, Stolen and Recovered'' at the Museum of Fine Arts and the exhibition ``Piero della Francesca: Intimate Encounters'' at The Metropolitan Museum of Art, imported from abroad for temporary exhibition... exhibit object at the Museum of Fine Arts, Boston, MA, from on or about September 13, 2013, until on or...

  11. Visual art and visual perception

    NARCIS (Netherlands)

    Koenderink, Jan J.


    Visual art and visual perception ‘Visual art’ has become a minor cul-de-sac orthogonal to THE ART of the museum directors and billionaire collectors. THE ART is conceptual, instead of visual. Among its cherished items are the tins of artist’s shit (Piero Manzoni, 1961, Merda d’Artista) “worth their

  12. La laicità francese secondo Nicolas Sarkozy

    Directory of Open Access Journals (Sweden)

    Maria d'Arienzo


    Full Text Available Il contributo è destinato agli Studi in onore del Professore Piero Pellegrino. SOMMARIO: 1. Premesse sul concetto di laicità – 2. Le radici della laicità in Francia – 3. Laicità e sentimento religioso nel discorso di Sarkozy – 4. La laicità positiva di Sarkozy. Un modello nuovo per la Francia?

  13. Disain on muutunud elustiili osaks / Ketlin Priilinn

    Index Scriptorium Estoniae

    Priilinn, Ketlin, 1982-


    1872. a. mööblitootmisega alustanud Taani ettevõttest Fritz Hansen, firmaga koostööd teinud disaineritest (Arne Jacobsen, Poul Kjarholm jt.). Piero Lissoni kujundatud 2006. a. kevad-suve kollektsioonist. Morten Vossi uut sarja Attitude sisaldavast 2006/2007 sügis-talve kollektsioonist. Vico Duo toolist (Vico Magistretti, 1997) ja Plano lauaseeriast (Pelikan Design, 2000)

  14. Particle physicists want to expand open access

    CERN Multimedia

    Kaiser, Jocelyn


    "Particle physicists have come up with a novel way to promote free, immediate access to journal articles. Led by CERN, the gian lab near Geneva, Switzerland, they want to raise at least $6 million a year to begin buying open access to all published papers in their field." (1 page)

  15. Oral health literacy among clients visiting a Rural Dental College in ...

    African Journals Online (AJOL)

    BACKGROUND: Limited health literacy among adults is one of the many barriers to better oral health outcomes. It is not uncommon to find people who consider understanding oral health information a challenge. Therefore, the present study assessed oral health literacy among clients visiting Gian Sagar Dental College and ...

  16. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences. VINCENZO IERARDI. Articles written in Journal of Biosciences. Volume 42 Issue 4 December 2017 pp 623-636 Article. Klebsiella pneumoniae antibiotic resistance identified by atomic force microscopy · VINCENZO IERARDI PAOLO DOMENICHINI SILVIA REALI GIAN MARCO ...

  17. Industrial organization and behaviour


    GNUTZMANN, Hinnerk


    Examining Board: Professor Thomas Gehrig, University of Vienna Professor Piero Gottardi, Supervisor, European University Institute Professor Andrea Mattozzi, European University Institute Professor Domenico Menicucci, University of Florence. Defence date: 10 September 2013 First made available online on 3 February 2014. This thesis collects three papers in industrial organization and behaviour, unified in their focus on the digital economy. The first two papers study markets for s...

  18. Immunological Prevention of Spontaneous Mammary Carcinoma in Transgenic Mice (United States)


    developed more slowly by transgenic FVB Anatomia Patologica, Ospedale S.S. Annunziata, Via Valignani, 66100 female mice carrying the wild-type proto...coopted (Pezzella et al., 1997). Anatomia Patologica. Ospedale SS. Annunziata, Via Valignani, 66100 Chieti, Italy. Fax: 39 0871 330471. E-mail: musiani...lo Studio e la Cura dei Tumori, Milan, Italy; and Reprints: Piero Musiani, G. d’ Annunzio University of Chieti, Anatomia Department of Experimental

  19. JPRS Report, West Europe. (United States)


    Piero Benetazzo; LA REPUBBLICA, 15 May 87) 43 NORWAY Poll Shows Most Support for Labor Party Government (AFTENPOSTEN, 18, 19 May 87) 46...Control of Fiat, IFI (Giuseppe Turani; LA REPUBBLICA, 8 May 87) 104 NORWAY Economists Urge Continuing Measures To Hold Line on Budget (AFTENPOSTEN...themselves which enterprise will be the next one to close down after the closing down of the chlorine production at the Soya Bean Cake Factory in

  20. A Secure and Efficient Communications Architecture for Global Information Grid Users Via Cooperating Space Assets (United States)


    Di Pietro , Roberto, Antonio Durante, and...MLD) for IPv6,, Accessed: May 22, 2006. [DiC05] Di Pietro , Roberto, Stefano Chessa, and Piero Maestrini, "Computation...Simultaneous Leaves Per Time Step To ta l K ey s Di st ri bu te d in th e Sy st em (l og s ca le ) Baseline Cluster Hubenko To ta l K ey s Di

  1. Il Basic Agreement tra la Santa Sede e la Bosnia- Erzegovina nel quadro delle dinamiche concordatarie ‘post-comuniste’

    Directory of Open Access Journals (Sweden)

    Germana Carobene


    Full Text Available Contributo destinato alla pubblicazione negli Studi in onore del Professore Piero Pellegrino. SOMMARIO: 1. Considerazioni introduttive. Configurazione giuridica delle attuali dinamiche concordatarie nei Paesi di recente strutturazione politico-giuridica - 2. L’Accordo del 2006 ed il suo contenuto normativo - 3. Evoluzione storica della Bosnia- Erzgovina fino all’attuale strutturazione politica - 4. Confronto con le regolamentazioni concordatarie degli altri Paesi dell’area balcanica e socialista. Conclusioni.

  2. Red wine and cardiovascular health the "French Paradox" revisited


    Giuseppe Lippi; Massimo Franchini; Gian Cesare Guidi


    Giuseppe Lippi1, Massimo Franchini2, Gian Cesare Guidi31U.O. di Diagnostica Ematochimica, 2Servizio di Immunoematologia e Trasfusione, Dipartimento di Patologia e Medicina di Laboratorio, Azienda Ospedaliero, Universitaria di Parma, Parma, Italy; 3Sezione di Chimica Clinica, Dipartimento di Scienze Morfologico-Biomediche, Università degli Studi di Verona, Verona, ItalyAbstract: The healthful and nutritive properties of wine have been acknowledged for thousands of years, but the obs...

  3. Use of oral contraceptives in the management of acne


    Melis, Gian; Paoletti,Anna Maria; ORRU' ,; MAROTTO ,; PILLONI,; PERSEU,; Lello,Stefano


    Gian Benedetto Melis, Marisa Orrù, Maria Francesca Marotto, Monica Pilloni, Mariagrazia Perseu, Stefano Lello, Anna Maria PaolettiClinica Ginecologica Ostetrica e di Fisiopatologia della Riproduzione Umana, Universita' di Cagliari, Azienda Ospedaliero Universitaria di Cagliari, Cagliari, ItalyAbstract: The pathogenesis of acne (the most common disorder involving the sebaceous gland) originates from increased sebum production by the sebaceous gland followed by colonization o...

  4. How Should The US Adapt Its Military Doctrine To Be Able TO Fight A Peer Competitor (United States)


    the American Way of War (New York: Colombia University Press, 2008), 195. 8. Quoted in Colonel Gian Gentile, Wrong Turn: America’s Deadly Embrace of...the American Way of War . New York: Colombia University Press, 2008. Mearsheimer, John J. The Tragedy of Great Power Politics, New York: W. W. Norton...AIR WAR COLLEGE AIR UNIVERSITY HOW SHOULD THE US ADAPT ITS MILITARY DOCTRINE TO BE ABLE TO FIGHT A PEER COMPETITOR? by Paul Kendall

  5. Bagatellid : maailm / Mirjam Tally

    Index Scriptorium Estoniae

    Tally, Mirjam, 1976-


    Kas imelastest heliloojad on tõsiselt võetavad? DG allkirjastas lepingu briti viiuldaja Daniel Hope'iga. USA plaaditööstus läheb allamäge, muusikainstrumentide müük ülesmäge.Stradivaariusest ja Guarneridest. Placido Domingo hakkab laulma baritonirolle. Itaalia helilooja Gian Carlo Menotti suri 95-aastaselt. Brian Ferneyhough võitis Ernst von Siemensi muusikaauhinna

  6. Andrea Corrado – Igor Mariottini, Cinema e autori sulle tracce delle migrazioni

    Directory of Open Access Journals (Sweden)

    Lorenzo Mari


    Full Text Available Nel dibattito pubblico così come, inevitabilmente, nel senso comune, l’interpretazione della storia post-unitaria italiana alla luce delle migrazioni – prima come flussi in uscita, poi sia in entrata che in uscita – ha innescato la costruzione di un preciso discorso retorico, alimentato da pubblicazioni come L’orda. Quando gli albanesi eravamo noi (2005 di Gian Antonio Stella.

  7. Il movimento degli scioperi nel XX secolo

    Directory of Open Access Journals (Sweden)

    Maria Theresa Schorer Petrone


    Full Text Available Cella, Gian Primo (organizador. Il movimento degli scioperi nel XX secolo. Bologna, Società Editrice Mulino, 1979. (primeiro parágrado do texto "O movimento das greves no século XX" constitui o resultado de laboriosa pesquisa realizada por um grupo de sociólogos— Guido 13oglioni, Lorenzo Bordogna, Gian Primo Cella, Pietro Kemeny, Giancarlo Provasi, Guido Romagnoli e Gian Enrico Rusconi — ligados às universidades de Turim, Parma, Trento e Cagliari.  Analisando com técnicas de quantificação, os mais variados aspectos das greves ocorridas desde o início deste século até 1970 na Grã Bretanha, Alemanha, Itália, França e nos Estados Unidos, e considerando esses niovimentos' os indicadores mais significativos da ação operária enquanto Manifestação sindical e reinvindicativa, acreditavam que poderiam de-teCtar as relações entre ação operária e as 'mudanças sociais.  O livro em questão é o resultado da primeira fase desta pesquisa em que se procurou reconstruir os movimentos grevistas e suas formas, chegando-se a construir modelos explicativos .

  8. Determination of PCDD/Fs in breast milk of women living in the vicinities of Da Nang Agent Orange hot spot (Vietnam) and estimation of the infant's daily intake. (United States)

    Hue, N T M; Nam, V D; Thuong, N V; Huyen, N T; Phuong, N T H; Hung, N X; Tuan, N H; Son, L K; Minh, N H


    Seventeen toxic congeners of polychlorinated dibenzo-p-dioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs) were determined in breast milks using the high resolution gas chromatography/high resolution mass spectrometry (HRGC/HRMS) method. Twenty seven breast milk samples were collected from primiparae who have lived over 5 years in wards namely Chinh Gian, An Khe, Khue Trung, and Hoa Thuan Tay which are located near the Da Nang Agent Orange hot spot (the AO/Dioxin hot spot). The samples were then analyzed for PCDD/F residues in order to assess the human exposure to dioxins from the AO/Dioxin hot spot, especially health risk to the breast-fed infants. The average TEQ levels in the four studied cohorts ranged from 8.1 to 26 pg/g lipid, with the highest level up to 51 pg TEQ/g lipid found in the An Khe ward. The TEQ level was correlated with geographical position and ranking in the order of Khue Trung, Hoa Thuan Tay, Chinh Gian and An Khe. The mean estimated PCDD/Fs infant's daily intake in the cohort of Khue Trung, Hoa Thuan Tay, Chinh Gian and An Khe was about 41, 122, 124, and 134 pg TEQ/kg bw/day, respectively, which are much higher than the tolerable daily intake proposed by the World Health Organization (4 pg TEQ/kg bw/day). Copyright © 2014 Elsevier B.V. All rights reserved.

  9. The Construction of Political Authority in the Governing Councils of the Florentine Republic (1494-1502

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    Jean-Marc RIVIÈRE


    Full Text Available The institutional changes in November-December 1494 upset the balance of power in Florence. After several years of hard struggle between the oligarchy and the middle classes, a modus vivendi is stated, based on a separation between the places where politics is considerated and the places where it is implemented. The election of Piero Soderini to the gonfalonierato for life, November 9, 1502, formalizes this new dichotomy between the centers of power and the heart of the political authority, opening onto a structural imbalance which is a major cause of the fall of the regime in 1512.

  10. The magic ring systems thinking approach to control systems

    CERN Document Server

    Mella, Piero


    This book presents a gradual path toward ""educating"" readers in understanding how Control Systems truly operate and in recognizing, simulating and improving them in all fields of activity. Starting from the hypothesis that knowledge of Control Systems is not only a technical fact but also represents a discipline - that is, ""A discipline is a developmental path for acquiring certain skills or competencies. (...) To practice a discipline is to be a lifelong learner. You ""never arrive""; you spend your life mastering disciplines."" (Senge, 2006, p. 10) - Piero Mella has set the objective of m

  11. Rõõmus kunst / Andri Ksenofontov

    Index Scriptorium Estoniae

    Ksenofontov, Andri, 1962-


    Alessandro Damiano (Itaalia) ratsamonumenditeemaline näitus "Varju-uurimus" ("Studi d'ombra") Tallinna Linnagaleriis 30. maini 2010. Tim Daviese (Wales) näitus "Seeria" 30. 04.-16. 05. 2010 ja Piero Steinle (Itaalia) näitus "Sinu päevad on loendatud" 13. juunini 2010 Tallinna Kunstihoone galeriis. Aili Vahtrapuu näitus "Naeruvõlu" Hobusepea galeriis 12.-24. maini 2010. Maria-Kristiina Ulase joonistuste näitus "Kunstniku nahk noore koera seljas" Haus Galeriis 18. juunini 2010

  12. The Mathematical Works of Leon Battista Alberti

    CERN Document Server

    Williams, Kim; Wassell, Stephen R


    Leon Battista Alberti was an outstanding polymath of the fifteenth century, alongside Piero della Francesca and before Leonardo da Vinci. While his contributions to architecture and the visual arts are well known and available in good English editions, and much of his literary and social writings are also available in English, his mathematical works are not well represented in readily available, accessible English editions have remained accessible only to specialists. The four treatises included here - Ludi matematici, De Componendis Cifris, Elementi di pittura and De lunularum quadratura - ar

  13. The scholar who created and breath life to the phenomenological pedagogy in Italy

    Directory of Open Access Journals (Sweden)

    Vanna Iori


    Full Text Available Piero Bertolini was one of the most important educational theorists in Italy and definitively the first referring in his works to Husserl's phenomenology. He initiated a pedagogical school of thought that regards education as an intentional act and not as a technical one, which can be presented as responsibility and a search for meaning. From this perspective, his studies focused on the relationship between educational sciences, on intentionality and Lebenswelt educational paradigms, relating them to the concrete educational experience. The foresights originated by Bertolini are more than ever updated to understand the decline of humanity in human relationships in the contemporary world.

  14. The stellar content of the isolated transition dwarf galaxy DDO210


    McConnachie, Alan W.; Arimoto, Nobuo; Irwin, Mike; Tolstoy, Eline


    We use Subaru Suprime-Cam and VLT FORS1 photometry of the dwarf galaxy DDO210 to study the global stellar content and structural properties of a transition-type galaxy (with properties intermediate between dwarf irregular and dwarf spheroidal systems). This galaxy is sufficiently isolated that tidal interactions are not likely to have affected its evolution in any way. The colour-magnitude diagrams of DDO210 show a red giant branch (RGB) population (with an RGB bump), a bright asymptotic gian...

  15. Liikuntateknologian vaikutus liikuntamotivaatioon


    Kurvinen, Kaarlo


    Tutkielmassa käsitellään liikuntateknologiaa, motivaatiota ja liikuntateknolo-gian vaikutusta liikuntamotivaatioon. Liikuntateknologian voidaan todeta ole-van suuressa merkityksessä teknologisoituneiden maiden urheilumarkkinoilla. Liikunnallisten teknologiatuotteiden suosio on noussut viimeisten vuosien aikana äkillisesti ja suosion myötä myös liikuntateknologisten tuotteiden mää-rä sekä kirjo ovat kasvaneet nopeasti. Liikuntateknologia tarjoaa käyttäjälleen lukuisia hyötyjä, joiden johdosta ...

  16. Report of the 1997 LEP2 working group on 'searches'

    International Nuclear Information System (INIS)

    Allanach, B.C.; Blair, G.A.; Diaz, M.A.


    A number of research program reports are presented from the LEP2 positron-electron collider in the area of searches for Higgs bosons, supersymmetry and supergravity. Working groups' reports cover prospective sensitivity of Higgs boson searches, radiative corrections to chargino production, charge and colour breaking minima in minimal Supersymmetric Standard Model, R-party violation effects upon unification predictions, searches for new pair-produced particles, single sneutrino production and searches related to effects similar to HERA experiments. The final section of the report summarizes the LEP 2 searches, concentrating on gians from running at 200 GeV and alternative paradigms for supersymmetric phenomenology. (UK)

  17. International Workshop on Diagnostics for ITER

    CERN Document Server

    Gorini, Giuseppe; Sindoni, Elio


    This book of proceedings collects the papers presented at the Workshop on Diagnostics for ITER, held at Villa Monastero, Varenna (Italy), from August 28 to September 1, 1995. The Workshop was organised by the International School of Plasma Physics "Piero Caldirola. " Established in 1971, the ISPP has organised over fifty advanced courses and workshops on topics mainly related to plasma physics. In particular, courses and workshops on plasma diagnostics (previously held in 1975, 1978, 1982, 1986, and 1991) can be considered milestones in the history of this institution. Looking back at the proceedings of the previous meetings in Varenna, one can appreciate the rapid progress in the field of plasma diagnostics over the past 20 years. The 1995 workshop was co-organised by the Istituto di Fisica del Plasma of the National Research Council (CNR). In contrast to previous Varenna meetings on diagnostics, which have covered diagnostics in present-day tokamaks and which have had a substantial tutorial component, the 1...

  18. Pedagogia fenomenologica e interpretazione della devianza / Pédagogie phénoménologique et interprétation de la déviance / Phenomenological pedagogy and interpretation of deviance

    Directory of Open Access Journals (Sweden)

    Cavana Laura


    Full Text Available Phenomenological pedagogy, introduced by Piero Bertolini in the second half of the past century, gets its fundamental and basic requirements from the phenomenology of Husserl, a German philosopher operating during the first years of 20th century.This article shows a synthesis of the key points of that pedagogical perspective applied to the field of juvenile deviance, and directly experimented by Bertolini himself during the decade 1958-1968, when he was the director of juvenile prison “ Beccaria” in Milan.According to phenomenological pedagogy, “difficult boys”, besides individual conditions and behavioural differences, of discomfort and rebelliousness, share the same difficulty in giving sense and meaning to the environment ( both human and material and a resulting difficulty in establishing with it true and pedagogically correct relationships, based on recognition and respect of the innermost relational structure of reality.

  19. Trends in discovery of new drugs for tuberculosis therapy. (United States)

    Riccardi, Giovanna; Pasca, Maria Rosalia


    After the introduction of isoniazid and rifampicin, the second one discovered in the Lepetit Research Laboratories (Milan, Italy), under the supervision of Professor Piero Sensi, tuberculosis (TB) was considered an illness of the past. Unfortunately, this infectious disease is still a global health fear, due to the multidrug-resistant Mycobacterium tuberculosis and extensively circulating drug-resistant strains, as well as the unrecognized TB transmission, especially in regions with high HIV incidence. In the last few years, new antitubercular molecules appeared on the horizon both in preclinical and clinical stage of evaluation. In this review, we focus on a few of them and on their mechanism of action. Two new promising drug targets, DprE1 and MmpL3, are also discussed.


    Directory of Open Access Journals (Sweden)

    Alfons Barceló


    Full Text Available No era Ernest Lluch individuo propenso a adoptar un singular libro de cabecera, ni a seguir con fidelidad las huellas de un único maestro. Pero, por supuesto, tenía su personal esquema devalores y sus escalas de preferencias. Y uno de los autores que sin discusión estaba presente en su galería privada de economistas ilustres fue Piero Sraffa (1898-1983. Creo que también habríacolocado en esa división de honor a François Quesnay, Adam Smith, David Ricardo, Karl Marx, Knut Wicksell, John M. Keynes, Joseph A.Schumpeter, Maurice H. Dobb, Wassily Leontief, John K. Galbraith, Paolo Sylos Labini y Albert O. Hirschman.

  1. Sobre las primeras ediciones del De re aedificatoria de Leon Battista Alberti

    Directory of Open Access Journals (Sweden)

    Suárez Quevedo, Diego


    Full Text Available El artículo glosa las dos primeras ediciones del De re aedificatoria de Alberti, ambas en latín, respectivamente de Florencia (1485, que es la edición princeps, y París (1512, a partir de los ejemplares conservados en la Biblioteca Histórica Marqués de Valdecilla. Al mismo tiempo establecer una visión paralela, entre la publicación de la primera, y la gestación y construcción del complejo de Poggio a Caiano, por parte de Lorenzo di Piero di Cosimo de’Medici (1449-1492, el Magnífico. Concluye con un acercamiento a la traducción española del De re efectuada por Francisco Lozano, y publicada en 1582, también tomando como referente el ejemplar de la Biblioteca Histórica.

  2. Literature in Focus Beta Beams: Neutrino Beams

    CERN Document Server


    By Mats Lindroos (CERN) and Mauro Mezzetto (INFN Padova, Italy) Imperial Press, 2009 The beta-beam concept for the generation of electron neutrino beams was first proposed by Piero Zucchelli in 2002. The idea created quite a stir, challenging the idea that intense neutrino beams only could be produced from the decay of pions or muons in classical neutrino beams facilities or in future neutrino factories. The concept initially struggled to make an impact but the hard work by many machine physicists, phenomenologists and theoreticians over the last five years has won the beta-beam a well-earned position as one of the frontrunners for a possible future world laboratory for high intensity neutrino oscillation physics. This is the first complete monograph on the beta-beam concept. The book describes both technical aspects and experimental aspects of the beta-beam, providing students and scientists with an insight into the possibilities o...

  3. La Fiat e la AutoVAZ di Togliatti. Alla ricerca del fordismo perduto

    Directory of Open Access Journals (Sweden)

    Valentina Fava


    Full Text Available In 1966 Vittorio Valletta, Fiat president, and the representatives of the Soviet Government signed the agreement that led to the building of the VAZ -Volzhsky Avtomobilny Zavod, a gigantic automobile plant. The Fiat-Soviet plant fostered the entrance of the Soviet Union (USSR in the «Automotive Century» and gave place to the first massive East-West transfer of technology and knowledge in the automobile sector of the century. The paper underscores the reasons of Fiat interest in the Soviet market, underlying how the deal had been coordinated with the Italian entrepreneurial elites and partially backed by the American Administration. Furthermore, the paper sheds light on the channels that Fiat used to enter in the Soviet market - focusing especially Fiat's agent, Piero Savoretti.

  4. Factors influencing choice of chemotherapy in metastatic colorectal cancer (mCRC

    Directory of Open Access Journals (Sweden)

    Rossi L


    Full Text Available Luigi Rossi, Foteini Vakiarou, Federica Zoratto, Loredana Bianchi, Anselmo Papa, Enrico Basso, Monica Verrico, Giuseppe Lo Russo, Salvatore Evangelista, Guilia Rinaldi, Francesca Perrone-Congedi, Gian Paolo Spinelli, Valeria Stati, Davide Caruso, Alessandra Prete, Silverio TomaoDepartment of Medico-Surgical Sciences and Biotechnologies, "Sapienza" University of Rome, Rome, Italy; Oncology Unit, ICOT, Latina, ItalyAbstract: Management of metastatic colorectal cancer requires a multimodal approach and must be performed by an experienced, multidisciplinary expert team. The optimal choice of the individual treatment modality, according to disease localization and extent, tumor biology, and patient clinical characteristics, will be one that can maintain quality of life and long-term survival, and even cure selected patients. This review is an overview of the different therapeutic approaches available in metastatic colorectal cancer, for the purpose of defining personalized therapeutic algorithms according to tumor biology and patient clinical features.Keywords: metastatic colorectal cancer, patient clinical features, tumor biology, multidisciplinary approach

  5. Herbal Prescriptions and Medicinal Herbs for Parkinson-Related Rigidity in Korean Medicine: Identification of Candidates Using Text Mining. (United States)

    Park, So Hyun; Hwang, Min Seob; Park, Hye Jin; Shin, Hwa Kyoung; Baek, Jin Ung; Choi, Byung Tae


    Dongeuibogam (DongYiBaoGian), one of the most important books in Korean medicine, comprises a comprehensive summary of all traditional medicines of North-East Asia before the 17th century. This medicinal literature was mined to establish a list of candidate herbs to treat Parkinson-related rigidity. A systematic search for terms describing Parkinson-related rigidity and candidate prescriptions for the treatment of Parkinson-related rigidity in the Dongeuibogam was performed. A high-frequency medicinal herb combination group and candidates for the treatment of Parkinson-related rigidity were also selected through an analysis of medicinal herb combination frequencies. The existing literature pertaining to the potential effects of candidate herbs for Parkinson-related rigidity was reviewed. Ten medicinal herb candidates for the treatment of Parkinson-related rigidity were selected, and their respective precedent studies were analyzed.

  6. External meeting: Geneva University

    CERN Multimedia


    Université de Genève Ecole de physique 24 quai Ernest Ansermet 1211 Genève 4 Tél : + 41 22 379 63 83 (secrétariat) Tél : + 41 22 379 62 56 (réception) Fax: + 41 22 379 69 22 Lundi 4 décembre 2006 17 heures - Auditoire Stueckelberg The Physics Behind the LHC Prof. Gian Francesco Giudice / CERN-TH   What do physicists want to discover with experiments at the LHC? What are we going to learn from the Higgs boson? What are the new phenomena that could be observed at the LHC? I will try to answer these questions using language accessible also to non-expert. More information:

  7. Networks in Cell Biology (United States)

    Buchanan, Mark; Caldarelli, Guido; De Los Rios, Paolo; Rao, Francesco; Vendruscolo, Michele


    Introduction; 1. Network views of the cell Paolo De Los Rios and Michele Vendruscolo; 2. Transcriptional regulatory networks Sarath Chandra Janga and M. Madan Babu; 3. Transcription factors and gene regulatory networks Matteo Brilli, Elissa Calistri and Pietro Lió; 4. Experimental methods for protein interaction identification Peter Uetz, Björn Titz, Seesandra V. Rajagopala and Gerard Cagney; 5. Modeling protein interaction networks Francesco Rao; 6. Dynamics and evolution of metabolic networks Daniel Segré; 7. Hierarchical modularity in biological networks: the case of metabolic networks Erzsébet Ravasz Regan; 8. Signalling networks Gian Paolo Rossini; Appendix 1. Complex networks: from local to global properties D. Garlaschelli and G. Caldarelli; Appendix 2. Modelling the local structure of networks D. Garlaschelli and G. Caldarelli; Appendix 3. Higher-order topological properties S. Ahnert, T. Fink and G. Caldarelli; Appendix 4. Elementary mathematical concepts A. Gabrielli and G. Caldarelli; References.

  8. Special Issue: Plant Genetics and Biotechnology in Biodiversity

    Directory of Open Access Journals (Sweden)

    Giandomenico Corrado


    Full Text Available The rapid progress and increasing affordability of novel investigation tools in plant genetics and biotechnology offer previously inaccessible opportunities for the exploitation of plant genetic diversity in agriculture. The Special Issue was lunched to highlight how new technologies are improving both genotyping and phenotyping methods, thus allowing us to uncover crop diversity and use genetic variability for plant breeding with remarkable precision and speed. Three thematic reviews report on scientific, technological, and legal advances in plant diversity and agriculture. Three contributions provide specific examples of the exploitation of different kinds of genetic resources, ranging from landraces to mutant populations. Six research articles are illustrative examples of the study of molecular and/or phenotypic diversity to address basic or applied questions in different plant species. Finally, this SI was also launched to honor the memory of Prof. Gian Tommaso Scarascia Mugnozza and a dedicated Editorial acknowledges his work in plant breeding and biodiversity protection.

  9. Roberto Dapit, La Slavia friulana - Beneška Slovenija. Lingue e culture: Resia, Torre, Natisone - Jezik in kultura: Rezija, Ter, Nadiža. Bibliografia ragionata - Kritična biblio­grafija, Circolo Zadroga "Lipa", San Pietro al Natisone - Špeter 1995, 138 p.

    Directory of Open Access Journals (Sweden)

    Mitja Skubic


    Full Text Available E' possibile che al linguista non slavista il titolo non dica gran che. Eppure, per merito anche del linguista polacco Ian Baudouin de Courtenay, il dialetto sloveno di Resia, del Torre e del Natisone, queste parlate slovene sono fra le più studiate, anche dai linguisti stranieri: De Courtenay, poi, più recentemente Gian Battista Pellegrini, Giu­ seppe Francescato, Giovanni Frau, Antonio Maria Raffo da parte italiana e friulana; per la parte slovena possiamo ricordare Karel Strekelj, Fran Ramovs, Tine Logar, Pavle Merkù, Neva Godini, Liliana Spinozzi-Monai, Rado Lencek. E' doveroso, poi, citare l'americano Eric Hamp e l'olandese Han Steenwijk. Un posto a parte spetta a Milka Maticetov perché congiunge gli interessi linguistici con quelli etnologici.

  10. Response of potato to drip and gun irrigation systems

    DEFF Research Database (Denmark)

    Zhenjiang, Zhou; Andersen, Mathias Neumann; Plauborg, Finn


    The objective of this study was to evaluate effects of different irrigation and N fertilization regimes by gun irrigation and drip-fertigation on potato production, and subsequently optimize the supply of water and N fertilizer to the growth condition of the specific season and minimize nitrate......-fertigation system (DFdsNds) and two gun irrigation systems (GIdsN120 and GIaN120) to display the differences on growth, yield and water use efficiency of potato. All treatments were irrigated according to model simulated soil water content. For fertilization all treatments received a basic dressing at planting of P......, K, Mg and micronutrients, and in addition 120 kg N/ha in the gun irrigated treatments and 36 kg N/ha in the drip-fertigated. For the latter, portion of 20 kg N/ha was applied whenever plant N concentration approached a critical value as simulated by the Daisy model. As a result differences in soil...

  11. Personality and destiny. Francesco Borromini: portrait of a tormented soul. (United States)

    Cipriani, Gabriele; Cipriani, Luca; Di Fiorino, Mario


    Francesco Borromini, one of the great geniuses of Baroque architecture, was tormented and solitary, and was increasingly frustrated by the fame and success of his rival, Gian Lorenzo Bernini. Borromini was an unhappy man, constantly dogged by disaster, quarrelling even with his best patrons and closest friends. In the culmination of one of the fits of depression that overcame the architect more and more frequently as his life progressed, Borromini literally fell on his own sword; he lingered in excruciating pain for 24 hours before dying. Largely forgotten, his architecture has again been recognized since the twentieth century as the creation of genius. We try to describe the personality and suicide of this pessimist giant of architecture.

  12. [Postpartum depression, neonatal hospitalization, and educational intervention]. [Article in Italian] • Depressione post partum, ospedalizzazione neonatale ed intervento educativo

    Directory of Open Access Journals (Sweden)

    Melania Picciau


    Full Text Available Postpartum depression (PPD is a non-psychotic depressive disease with varying severity, from moderate to severe, which originates after the 4th week from giving birth. At our hospital, a clinical approach to help mothers in a delicate period of their life was performed in 2 phases, in the first week of life during hospitalization of the newborn and after the 4th-6th week after delivery. The main instrument in use for the screening of PPD and used also in our study was the Edinburgh Postnatal Depression Scale (EPDS. Results are presented concerning in particular the correlations between EPDS and variables such as maternal characteristics and lenght of neonatal hospitalization. Articoli Selezionati del Congresso “Medicina Narrativa e Comunicazione nella Pratica Clinica” · Cagliari · 14 Aprile 2014 Guest Editors: Massimiliano Zonza, Vassilios Fanos, Gian Paolo Donzelli

  13. By invitation only

    CERN Multimedia

    Antonella Del Rosso


    The Hôtel Métropole in Brussels is a legendary conference venue that will ring a bell to all physicists. 100 years after the first meeting of the Conseil de Physique Solvay, a representative group of the world’s most eminent physicists met again in October this year in the Excelsior Room to discuss “The Theory of the Quantum World”. Three members of CERN's Theory Group were invited to participate. Gian Giudice, one of them, shares with us his thoughts and impressions about this exclusive conference.   Attendees at the 25th Solvay Conference on Physics, Brussels. Photo provided by "International Solvay Institutes". “In the tradition of the Solvay Conferences, this is a discussion-oriented meeting with few talks by rapporteurs.” Thus reads the Introduction to the Scientific Programme of the Solvay Conference on Physics. In the Conference programme, the rapporteurs speak for only 30 minutes,...

  14. Técnicas constructivas altomedievales en la ciudad de Pisa y en la Toscana nordoccidental

    Directory of Open Access Journals (Sweden)

    Quirós Castillo, Juan Antonio


    Full Text Available The present work analyses the building techniques used in the city of Pisa in the Early Middle Ages. Four ecclesiastical constructions are precisely studied (San Piero a Grado, San Zeno, Santa Cristina, San Matteo, leading to the understanding of the transformations that have taken place in the organizational structure of the architectural production. It is also paid specific attention to the constructive materials, to the diachronic evolution of the building techniques in the territory of Pisa and to the zeal that has supposed the realization of the Early Middle Ages religious architecture through the analysis of the volumetric dimensions of these constructions. Lastly, a social reading of the architectural production from the 5th to the 10th centuries is carried out.En el presente trabaja se analizan las técnicas constructivas empleadas en la ciudad de Pisa en la Alta Edad Media. Más concretamente se estudian de forma detallada cuatro construcciones eclesiásticas (San Piero a Grado, San Zeno, Santa Cristina, San Matteo, a través de las cuales es posible comprender las transformaciones que han tenido lugar en la estructura organizativa de la producción arquitectónica. Se presta igualmente una atención específica a los materiales constructivos, a la evolución diacrónica de las formas de construir en el territorio pisano y al empeño que ha supuesto la realización de la arquitectura religiosa altomedieval a través del análisis de las dimensiones volumétricas de estas construcciones. Por último se realiza una lectura social de la producción arquitectónica en los siglos V-X.

  15. Poster: The EURISOL Beta-beam facility

    CERN Document Server

    The beta-beam concept for the generation of an electron (anti-)neutrino beam was proposed by Piero Zucchelli (CERN) in 2002. A first study of the possibility of using the existing CERN machines for the acceleration for radioactive ions to a relativistic gamma of roughly 100, for later storage in a new decay ring of approximately the size of SPS, was made in 2002. The results from this very first short study were very encouraging.In 2004 it was decided to incorporate a design study for the beta-beam within the EURISOL DS proposal. EURISOL is a project name for a next-generation radioactive beam facility based on the ISOL method for the production of intense radioactive beams for nuclear physics, astrophysics and other applications. The proposal was accepted with the beta-beam task as an integral part. The design study officially started 1 February 2005 and will run for 4 years resulting in a conceptual design report for a beta-beam facility.

  16. Water consumption of the estevia (Stevia rebaudiana (Bert. Bertoni crop estimated through microlysimeter

    Directory of Open Access Journals (Sweden)

    Fronza Diniz


    Full Text Available The knowledge of water requirement of crops in the different growing phases elicits higher crop yield and rational use of water resource. The aim of this work was to estimate the water consumption of stevia using two constant watertable microlysimeters. The research was conducted in San Piero a Grado, Pisa, Italy. The data were collected daily from June, 1st, to October, 22th, 2000. Reference evapotranspiration was determined by the Penman-Monteith-FAO method, in the same period. Microlysimeters watertables level were maintained at the 35 cm depth. Crop evapotranspiration for the total cicle (80 days was 464 mm. For the most water consuming phase, crop average evapotranspiration was 5.44 mm day-1. The crop coefficient values were 1.45 for the first 25 days, 1.14 for the next period (26 to 50 days, and 1.16 for the latest period (51 to 80 days. The stevia leaf yield of the microlysimeters was 4.369 kg ha-1 and their steviosideo content 6.49%.

  17. Radioelectric asymmetric brain stimulation and lingual apex repositioning in patients with atypical deglutition

    Directory of Open Access Journals (Sweden)

    Castagna A


    Full Text Available Alessandro Castagna1, Salvatore Rinaldi1,2, Vania Fontani1, Piero Mannu11Rinaldi-Fontani Institute, 2School of Occupational Medicine, University of Florence, Florence, ItalyBackground: Atypical deglutition is exacerbated by stress and anxiety. Several therapeutic approaches have been employed to treat stress and anxiety disorders, ranging from typical psychopharmacological strategies to novel physical protocols, such as transcranial magnetic stimulation and radioelectric asymmetric conveyor (REAC stimulation. The purpose of the present study was to test the efficacy of REAC brain stimulation in atypical deglutition.Methods: The position of the lingual apex (Payne method, pattern of free deglutition, and subjective and objective impression of deglutition were evaluated in 128 outpatients suffering from atypical deglutition. Deglutition testing consisted of an operator holding down the lower lip, hence counteracting the strength exerted by the orbicularis muscle. All subjects were treated using two REAC brain stimulation protocols. Patients were assessed before treatment, immediately after treatment, and three months following the last cycle of REAC therapy.Results: REAC stimulation led to an improvement in positioning of the lingual apex and a significant decrease of muscle involvement in all patients immediately after REAC treatment, and the improvement was maintained at three-month follow-up.Conclusion: In the present study, the REAC therapeutic protocols led to normalization in lingual apex positioning and significant improvement in swallowing in all participants suffering from atypical deglutition.Keywords: atypical deglutition, stress, anxiety, radioelectric asymmetric brain stimulation

  18. Working group on VVER safety analysis - report of the 2010 meeting

    International Nuclear Information System (INIS)

    Kliem, S.


    The AER Working Group D on WWER reactor safety analysis held its nineteenth meeting in Pisa, Italy, during the period 15-16 April, 2010. The meeting was hosted by the San Piero a Grado Nuclear Research Group of the University of Pisa and was held in conjunction with the second workshop on the OECD/NEA Benchmark for the Kalinin-3 WWER-1000 NPP and the fourth workshop on the OECD Benchmark for Uncertainty Analysis in Best-Estimate Modelling (UAM) for Design, Operation and Safety Analysis of LWRs. Altogether 12 participants attended the meeting of the working group D, 8 from AER member organizations and 4 guests from non-member organization. The co-ordinator of the working group, Mr. S. Kliem, served as chairman of the meeting. The meeting started with a general information exchange about the recent activities in the participating organizations. The given presentations and the discussions can be attributed to the following topics:-Code validation and benchmarking including the calculation of the OECD/NEA Benchmark for the Kalinin-3 WWER-1000 NPP;-Safety analyses and code developments;-Future activities A list of the participants and a list of the handouts distributed at the meeting are attached to the report. The corresponding PDF-files can be obtained from the chairman. (Author)

  19. Three saints with deformed extremities in an Italian Renaissance altarpiece. (United States)

    Albury, W R; Weisz, G M


    A fifteenth-century Florentine altarpiece painted by the Pollaiuolo brothers, Antonio (1433-1498) and Piero (1443-1496), shows three saints with evident deformities of the hands and feet. The pathologies concerned are tentatively identified, and various rationales for their presence in the painting are discussed. Of particular importance is the location of the altarpiece in a chapel which houses the tomb of the Cardinal of Portugal, Prince James of Lusitania (1433-1459). It is argued that both the artistic style of the day and the religious symbolism of the Cardinal's funeral chapel contributed to the artists' decision to portray the saints with deformities. An unnatural curvature of the fifth finger was apparently considered elegant in fifteenth-century paintings, and the depiction of bare feet with hallux valgus gave them a shape which approximated and could have been caused by fashionable pointed shoes. But in addition, deformities in religious art could be symbolic of suffering and martyrdom, a theme which the Cardinal's chapel emphasised in a number of ways. It is suggested therefore that the Pollaiuolo altarpiece reconciles these two disparate factors, portraying genuine deformities in a way that was artistically stylish and symbolically meaningful.

  20. The Monocular Duke of Urbino. (United States)

    Schwartz, Stephen G; Leffler, Christopher T; Chavis, Pamela S; Khan, Faraaz; Bermudez, Dennis; Flynn, Harry W


    Federico da Montefeltro (1422-1482), the Duke of Urbino, was a well-known historical figure during the Italian Renaissance. He is the subject of a famous painting by Piero della Francesca (1416-1492), which displays the Duke from the left and highlights his oddly shaped nose. The Duke is known to have lost his right eye due to an injury sustained during a jousting tournament, which is why the painting portrays him from the left. Some historians teach that the Duke subsequently underwent nasal surgery to remove tissue from the bridge of his nose in order to expand his visual field in an attempt to compensate for the lost eye. In theory, removal of a piece of the nose may have expanded the nasal visual field, especially the "eye motion visual field" that encompasses eye movements. In addition, removing part of the nose may have reduced some of the effects of ocular parallax. Finally, shifting of the visual egocenter may have occurred, although this seems likely unrelated to the proposed nasal surgery. Whether or not the Duke actually underwent the surgery cannot be proven, but it seems unlikely that this would have substantially improved his visual function.

  1. Lune

    CERN Document Server

    Romagnoli, Edoardo; Bianucci, Piero


    Un'opera unica nel suo genere, nata dall'incontro di due grandi artisti, il fotografo Edoardo Romagnoli e il designer Giulio Confalonieri, recentemente scomparso. Protagonista è la Luna, colta dall'obiettivo della macchina fotografica e ritratta attraverso fotografie sorprendenti e di forte impatto emotivo (alcune esposte al Guggenheim Museum di Venezia). Grafica e fotografia si susseguono e si inseguono, senza interferire l'una con l'altra. Un "passo a due", dove ogni pagina di grafica introduce una pagina di fotografia e, dopo ogni fotografia, appare una pagina di grande effetto grafico. La meraviglia è forte e il ritmo incalzante. Il legame è in copertina: una grande "E" (congiunzione) a rappresentare il rapporto forte tra design e fotografia, immagini e grafica, ma allo stesso tempo anche il profondo piacere dello stare insieme a parlare, fare e disfare, rifare e riparlare, dei due principali attori di quest'opera, il designer e il fotografo. Il tutto accompagnato dal contributo di Piero Bianucci, scri...

  2. War songs and songs of war: the poetry in B minor by Fabrizio De André

    Directory of Open Access Journals (Sweden)

    Gleiton Lentz


    Full Text Available The 2nd half of last century, the Italian composer Fabrizio De André (1940-1999 occupied a prominent place in the history of Italian song and even the modern Italian poetry. His fans admire the moral courage and artistic coherence with which he, in the post-war Italian society, through his libertarian and pacifist songs, portrayed the world of the marginalized, the rebels and the prostitutes, and other characters on the margins of society, among those, the war combatant, hero of lost victories on the battlefield. Three of his songs are emblematic: La Ballata dell'eroe, La Guerra di Piero and Girotondo. Three poems that talk about war, death, and the figure of the combatant as an outcast of society, that kills him and then relegates him to oblivion, on behalf of the Fatherland. Exposing his provocative vision of post-war society by showing two videos of the composer is the purpose of this presentation.

  3. CONFERENCE DESCRIPTION Theory of Fusion Plasmas: Varenna-Lausanne International Workshop (United States)

    Garbet, X.; Sauter, O.


    The Joint Varenna-Lausanne international workshop on Theory of Fusion Plasmas takes place every other year in a place particularly favourable for informal and in-depth discussions. Invited and contributed papers present state-of-the-art research in theoretical plasma physics, covering all domains relevant to fusion plasmas. This workshop always welcomes a fruitful mix of experienced researchers and students, to allow a better understanding of the key theoretical physics models and applications. Theoretical issues related to burning plasmas Anomalous Transport (Turbulence, Coherent Structures, Microinstabilities) RF Heating and Current Drive Macroinstabilities Plasma-Edge Physics and Divertors Fast particles instabilities Further details: The conference is organized by: Centre de Recherches en Physique des Plasmas, Ecole Polytechnique Fédérale de Lausanne, Association EURATOM - Confédération Suisse 'Piero Caldirola' International Centre for the Promotion of Science and International School of Plasma Physics Istituto di Fisica del Plasma del CNR, Milano Editors: X Garbet (CEA, Cadarache, France) and O Sauter (CRPP-EPFL, Lausanne, Switzerland)

  4. CineClub

    CERN Multimedia



      On the occasion of CERN’s 60th anniversary the CERN CinéClub will be showing films from all CERN member states   Thursday 8 May 2014 at 20:00 CERN Council Chamber Tabu   Directed by Miguel Gomes (Portugal, 2012) 118 minutes      Directed by Jérome le Maire (Belgium, 2006) 87 minutes   TABU is a diptych starting off in present day Lisbon with Pilar, a woman concerned about her neighbour Aurora’s eccentricities.  Pilar meets Gian Luca, a man from Aurora’s past.  He starts his story and the film jumps back in time to colonial Africa, where he and Aurora had a passionate love affair. The second part is made of a quasi-silent film, with no dialogue, just music and voice-over. With a soundtrack that ranges from Lisztian piano music to cover versions of Phil Spector, TABU is just a delight.  Not to mention the sad and melancholy crocodile.. Original version P...

  5. Discussion on ``Foundations of the Second Law'' (United States)

    Silbey, Robert; Ao, Ping; Beretta, Gian Paolo; Cengel, Yunus; Foley, Andrew; Freedman, Steven; Graeff, Roderich; Keck, James C.; Lloyd, Seth; Maroney, Owen; Nieuwenhuizen, Theodorus M.; Weissman, Michael


    This article reports an open discussion that took place during the Keenan Symposium "Meeting the Entropy Challenge" (held in Cambridge, Massachusetts, on October 4, 2007) following the short presentations—each reported as a separate article in the present volume—by Seth Lloyd, Owen Maroney, Silviu Guiasu, Ping Ao, Jochen Gemmer, Bernard Guy, Gian Paolo Beretta, Speranta Gheorghiu-Svirschevski, and Dorion Sagan. All panelists and the audience were asked to address the following questions • Why is the second law true? Is it an inviolable law of nature? If not, is it possible to develop a perpetual motion machine of the second kind? • Are second law limitations objective or subjective, real or apparent, due to the nature of physical states or the representation and manipulation of information? Is entropy a physical property in the same sense as energy is universally understood to be an intrinsic property of matter? • Does the second law conflict with quantum mechanics? Are the differences between mechanical and thermodynamic descriptions of physical phenomena reconcilable? Does the reversible law of motion of hamiltonian mechanics and quantum mechanics conflict with the empirical observation of irreversible phenomena?

  6. Spotlight on ertugliflozin and its potential in the treatment of type 2 diabetes: evidence to date

    Directory of Open Access Journals (Sweden)

    Cinti F


    Full Text Available Francesca Cinti,* Simona Moffa,* Flavia Impronta,* Chiara MA Cefalo, Vinsin A Sun, Gian Pio Sorice, Teresa Mezza, Andrea Giaccari Center for Endocrine and Metabolic Diseases, Fondazione Policlinico Universitario A Gemelli, Università Cattolica del Sacro Cuore, Rome, Italy *These authors contributed equally to this work Abstract: Sodium-glucose cotransporter 2 (SGLT2 inhibitors are the latest therapeutic strategy in the treatment of type 2 diabetes mellitus (T2DM. Using an insulin-independent mechanism (glycosuria, they reduce glucose toxicity and improve insulin sensitivity and β-cell function. The promising results obtained in clinical trials show that SGLT2 significantly improves glycemic control and provides greater cardiovascular protection, combined with a reduction in body weight and blood pressure (BP. This review focuses on ertugliflozin, a new, highly selective, and reversible SGLT2 inhibitor. Clinical trials published to date show that ertugliflozin, both as a monotherapy and as an add-on to oral antidiabetic agents, is safe and effective in reducing glycosylated hemoglobin (HbA1c, body weight, and BP in T2DM patients. Keywords: antidiabetic drugs, glycosylated hemoglobin, glycemic control, sodium-glucose cotransporter 2 inhibitors, precision medicine, type 1 diabetes mellitus, type 2 diabetes mellitus, weight reduction 

  7. Higgs boson: the winner takes it all?

    CERN Multimedia

    Antonella Del Rosso


    Since its discovery in 2012, the Higgs boson has been in the spotlight for both experimentalists and theorists. In addition to its confirmed role in the mass mechanism, recent papers have discussed its possible role in the inflation of the universe and in the matter-antimatter imbalance. Can a single particle be responsible for everything?   “Since 2012 we have known that the Higgs boson exists, but its inner properties are yet to be completely uncovered,” says Gian Giudice, a member of the CERN Theory Unit. “Precise measurements of its decay modes are still ongoing and the LHC Run 2 will be essential to understand the nature of this particle at a deeper level.” What we know is that this boson is not “yet another particle” among the hundreds that we deal with every day in physics labs. In agreement with the Standard Model theory, the recent experimental data confirms that the particle discovered by the CERN experiments is the key pa...

  8. In depth analysis of motivational factors at work in the health industry. (United States)

    Bajwa, Sukhminder Jit Singh; Virdi, Sandeep Singh; Bajwa, Sukhwinder Kaur; Ghai, Gagandeep Kaur; Singh, Kamaljit; Rana, Chandeep Singh; Singh, J P; Raj, Sahil; Puri, Anju


    Motivation of health workers is necessary to generate the organizational commitment towards the patients and the hospital and therefore the knowledge about what motivates and satisfies them is very essential.The aim of the project was to investigate and analyze the various factors that help in motivation of the health workers while performing their clinical duties in the hospital. A simple random study was conducted among 100 employees of our institute, which included doctors, staff nurses and paramedical staff. One hundred employees from Gian Sagar Institute were chosen randomly for the purpose of our study. All the employees were enquired by the questionnaire method as well as by individual interviews regarding the various motivating and demotivating factors at the work place. Detailed enquiries were performed regarding the various aspects concerning the job factors and work satisfaction. All the answers and findings were observed and recorded. Simple non-parametric tests like mean, percentages and chi square tests were employed to analyze the data.The demographic profile of all the employees showed only minor differences which were statistically non-significant. Skills, task identity, task significance, autonomy, feedback, environment, job security and compensation were observed to be the important factors for the motivation of employees. The depth and the extent to which these factors were studied at work in the hospital showed remarkable differences. All the factors studied in this project are essential basis for organizational commitment, but feedback represents the factor with the highest motivation potential especially among the younger population.

  9. Lightening the dark

    CERN Multimedia

    Francesco Poppi


    About 96% of the Universe is in the form of unknown matter and energy. The rest – only 4% – is the ‘ordinary matter’ that we are made of and that makes up all the planets, the stars and the galaxies we observe. The LHC experiments have the potential to discover new particles that could make up a large fraction of the Universe.   In recent years, scientists have collected various evidence of the existence of a new type of matter in the Universe. They call it ‘dark’ because it does not emit or absorb electromagnetic radiation. "One of the main proofs of its existence comes from the measurement of the rotational speed of astronomical bodies in spiral galaxies", explains Gian Giudice, a member of CERN's Theory group and the author of "A Zeptospace Odyssey", a recent book on LHC physics aimed at the general public. According to the Newtonian laws of motion, this value varies as a function of the distance fr...

  10. Interview with Karol Modzelewski

    Directory of Open Access Journals (Sweden)

    Paola Guglielmotti


    Full Text Available The first section of this interview addresses the political and cultural milieu that shaped Karol Modzelewski’s education (in Poland and Italy, too, the relations with both his mentor Aleksander Gieysztor and the historians of the previous generation, the condition of education in Poland especially in the ’60s, his political involvement, the selection of his research interests and the development the latter underwent. Then the interview examines Modzelewski’s relations with scholars belonging to other historiographical schools, with particular attention to the issue of ethnogenesis, the methodology concerning the structure of sources to reconstruct the history of the Barbarian world in the first millennium, the matter of the “Barbaric collectivism”, the reception of his study L’Europa dei barbari (‘The Europe of the Barbarians’, 2004, and finally how research is organized and evaluated in Poland. Quotable as Intervista a Karol Modzelewski, a cura di Paola Guglielmotti e Gian Maria Varanini, "Reti Medievali - Rivista", 11, 1 (2010, p. 509-579, url: .

  11. Literature in Focus - A Zeptospace Odyssey: A Journey into the Physics of the LHC

    CERN Multimedia

    CERN Library


    By Gian Francesco Giudice (CERN) Oxford University Press, 2009 At this very moment the most ambitious scientific experiment of all time is beginning, and yet its precise aims are little understood by the general public. This book aims to provide an everyman’s guide for understanding and following the discoveries that will take place within the next few years at the Large Hadron Collider project at CERN. The reader is invited to share an insider’s view of the theory of particle physics, and is equipped to appreciate the scale of the intellectual revolution that is about to take place. The technological innovations required to build the LHC are among the most astonishing aspects of this scientific adventure, and they too are described here as part of the LHC story. The book culminates with an outline of the scientific aims and expectations at the LHC. Does the mysterious Higgs boson exist? Does space hide supersymmetry or extend into extra dimensions? How can colliding protons at the LHC...

  12. Is there life out there ? - A new series for the ESA's Web TV (United States)

    Clervoy, J. F.; Coliolo, F.


    The European Space Agency, ESA, is preparing a new outreach project: a series of short videos for the ESA's Web TV dedicated to the search for life in the Universe. The rationale behind this pilot project is to use stunning images to attract the attention together with a scientific content accessible to people of varying ages, education levels and cultural outlook. We intent to work with scientists across Europe in order to bring the public on a journey from the boundaries of the Cosmos to the core of the Earth looking for the ingredients necessary for life to form and evolve. Our main objectives are: to share discovery, curiosity and sense of adventure in order to make the public a player in the quest of knowledge about who we are, and where do we come from; to educate and engage different target audiences about European space science and exploration activities; encourage international partnerships. I will present you the first trailer that we have realised with two scientists: André Brack, Astrobiologist, Honorary Director of Research at the CNRS, Orleans, France and Gian Gabriele Ori, Research professor in Geology, and Director of the IRSPS, International Reaserch School of Planetary Science, Pescara, Italy. This first presentation gives an overview of the « exobiological » places beyond the Earth and highlights the importance of comparative planetology for better understand our planet. We would like to share with you ideas and advices in order to produce and diffuse this series in the most efficient way.

  13. An analysis of the combination frequencies of constituent medicinal herbs in prescriptions for the treatment of bone and joint disorder in Korean medicine: determination of a group of candidate prescriptions for universal use

    Directory of Open Access Journals (Sweden)

    Yoo Kyoung Han


    Full Text Available Background: This study aimed to select prescriptions (mixtures of medicinal herbs used in the treatment of bone and joint disorders in Korean medicine, and through the analysis of medicinal herb combination frequencies, select a high-frequency medicinal herb combination group for further experimental and clinical research. Methods: We systematically searched for terms related to bone and joint disorder in the “Dongeuibogam (Dong yibaojian”, a seminal Korean medicine book. We reviewed the results of published papers regarding the effects in bone and joint disorders (especially in osteoporosis, osteomalacia, osteopenia, rheumatoid arthritis, and degenerative arthritis. Results: In total, 34 candidates of a medicinal herb combination for the treatment of bone and joint disorders(CMHCTBJDs and nine candidates of a medicinal herb for the treatment of bone and joint disorders(CMHTBJDs were selected. Conclusion: : The candidates of a medicinal herb combination for the treatment of bone and joint disorders (CMHCTBJDs and candidates of a medicinal herb for the treatment of bone and joint disorders(CMHTBJDs proposed in this study can be useful material for text mining to develop natural products with the effects in BJDs and also it has the potential to reduce the experimental and developmental time period. Keywords: Dongeuibogam (Dong yi bao gian, Text mining, Bone disorder

  14. Reseñas/Book Reviews

    Directory of Open Access Journals (Sweden)

    Book Review Editor, Barbara Hogenboom


    Full Text Available Pistoleros and Popular Movements. The Politics of State Formation in Postrevolutionary Oaxaca, by Benjamin T. Smith; reviewed by Wil Pansters, p.128Exceptional Violence. Embodied Citizenship in Transnational Jamaica, by Deborah A. Thomas; reviewed by Gert Oostindie, p. 130The Guatemala Reader: History, Culture, Politics (The Latin America Readers, compilado por Greg Grandin, Deborah T. Levenson, Elizabeth Oglesby; reviewed by Manuela Camus, p. 131The Resurgence of the Latin American Left, edited by Steven Levitsky and Kenneth M. Roberts; reviewed by Peadar Kirby, p. 133Latin America in the 21st Century: Nations, Regions, Globalization, by Gian Luca Gardini; reviewed by Daniel Hellinger, p. 134The New Politics of Protest, by Roberta Rice; reviewed by Michiel Baud, p. 136Mercury, mining and empire. The human and ecological cost of colonial silver mining in the Andes, por Nicholas Robins; reviewed by Raquel Gil Montero, p. 138Bolivia. Refounding the Nation, by Kepa Artaraz; reviewed by Isabella Margerita Radhuber, p. 139Allende’s Chile and the Inter-American Cold War, by Tanya Harmer; reviewed by Gisela Cramer, p. 141The Politics of Sexuality in Latin America. A Reader on Lesbian, Gay, Bisexual, and Transgender Rights, compilado por Javier Corrales y Mario Pecheny; reviewed by José Carlos G. Aguiar, p. 144

  15. Tridentine renewal and spiritual education of women in the experience of female monasticism. The case of Verona in the sixteenth century

    Directory of Open Access Journals (Sweden)

    Elisabetta Patrizi


    Full Text Available The catholic world of the Sixteenth century, especially after the Council of Trent, exalted the condition of monastic life as the most perfect and noblest of the conditions of life traditionally reserved for women. The monastic state became the model to which the educational path of every woman had to conform to, even if she was destined to live in the world (as mother, virgin, widow, or married woman. The strong paradigmatic value exerted by the monastic condition of life is clear from the analysis of the pedagogical literature devoted to women published in this period.The present article focuses on two relevant examples of this literature: the Costituzioni per le monache (Constitutions for Nuns, 1539 by Gian Matteo Giberti and the Ricordi lasciati alle monache (Recollections left to nuns, 1575 by Agostino Valier. The two texts contain very interesting reasons for understanding the pedagogical directions of the time, which are highlighted by the author with specific references to the historical context and thanks to the support of documentary and published sources. These two works were written by two great reformer bishops, and are highly meaningful not only because they complement each other, since both were prepared for the religious women of the diocese of Verona, but mainly because they offer one very vivid insight into the growing importance assigned to the monastic modus vivendi in Sixteenth century Catholic society.

  16. Staff members with 25 years’ service at CERN in 2008

    CERN Multimedia


    The 47 staff members who have spent 25 years within CERN in 2008 were invited by the Director-General to a reception in their honour on 24 October. Mr.\tAllen\tDavid John\tAB Dr.\tBailey\tRoger\tAB Mr.\tBlas\tAlfred\tAB Mr.\tBobbio\tPiero\tAB Dr.\tBona\tMaurizio\tSC Mr.\tBrachet\tJean-Pierre\tTS Dr.\tBurckhart\tHelfried\tPH Miss\tButtay\tCatherine\tFI Mr.\tCatherall\tRichard\tAB Mr.\tCoin\tAndré-Yvon\tTS Dr.\tCornelis\tKarel\tAB Dr.\tDavenport\tMartyn\tPH Mr.\tDehavay\tClaude\tAB Mr.\tDenblyden\tJean-Loup\tPH Mr.\tDenis\tBernard\tDSU Mr.\tDuret\tMax\tAT Mr.\tEvans\tJohn\tIT Mrs.\tFavrot\tVéronique\tIT Mr.\tFowler\tAntony\tAB Mrs.\tGalmant\tCatherine\tAB Mr.\tGuillaume\tJean-Claude\tTS Mrs.\tJerdelet\tJocelyne\tDSU Dr.\tKostro\tKrzysztof\tAB Mr.\tKuczerowski\tJoseph\tAB Mr.\tLappe\tJean-Pierre\tTS Mrs.\tLaverrière\tCatherine\tSC Mr.\tLeggiero\tLuigi\tTS Mr.\tManglunki\tDjango\tAB Mr.\tMartens\tReinoud\tIT Mr.\tMartinez\tGeorges\tSC Mr.\tMonchalin\tPhilippe\tSC Mr.\tMoret\tPhilippe\tDSU Mr.\tOlesen\tGert\tPH Mr.\tPasinelli\tSergi...

  17. Cariogram outcome after 90 days of oral treatment with Streptococcus salivarius M18 in children at high risk for dental caries: results of a randomized, controlled study

    Directory of Open Access Journals (Sweden)

    Di Pierro F


    Full Text Available Francesco Di Pierro,1 Alberto Zanvit,2 Piero Nobili,2 Paolo Risso,3 Carlo Fornaini4 1Scientific Department, Velleja Research, 2Stomatology Institute, Milan, Italy; 3Department of Health Science, University of Genoa, Genoa, Italy; 4Teleo Laboratory, Faculty of Dentistry, University of Nice, Nice, France Abstract: Dental caries is the most common chronic disease of childhood. Cariogram is a well-recognized algorithm-based software program based on different caries-related risk factors and intended to aid clinicians in performing more objective and consistent dental caries risk assessments. This type of approach precedes the diagnosis of caries and allows the dentist to identify at-risk patients and then take appropriate preventive measures before caries develop further. One of the etiological factors favoring the development of dental caries is the mutans streptococci. These acidogenic dental plaque inhabitants can be effectively antagonized by the activity of bacteriocins released by the probiotic Streptococcus salivarius M18 (salivarius M18. Moreover, salivarius M18 after colonizing the human oral mucosa produces the enzymes dextranase and urease that are able to counteract plaque formation and saliva acidity, respectively. Seventy-six subjects at high risk of dental caries were randomized and then either treated or not treated for 90 days with an oral formulation containing the oral probiotic salivarius M18 (Carioblis®. The results indicate that the use of salivarius M18 increases the chances of avoiding new dental caries development in children, and its application could be proposed as a new tool in the dentist's armory to be adopted in subjects considered at high risk on the basis of their Cariogram outcome. Keywords: BLIS M18, caries prediction, dextranase, urease, Streptococcus mutans, Streptococcus sobrinus, plaque, salivary pH, bacteriocins

  18. Investigation of interactions between poly-L-lysine-coated boron nitride nanotubes and C2C12 cells: up-take, cytocompatibility, and differentiation

    Directory of Open Access Journals (Sweden)

    G Ciofani


    Full Text Available G Ciofani1, L Ricotti1, S Danti2,3, S Moscato4, C Nesti2, D D’Alessandro2,4, D Dinucci5, F Chiellini5, A Pietrabissa3, M Petrini2,3, A Menciassi1,61Scuola Superiore Sant’Anna, Pisa, Italy; 2CUCCS-RRMR, Center for the Clinical Use of Stem Cells – Regional Network of Regenerative Medicine, 3Department of Oncology, Transplants and Advanced Technologies, 4Department of Human Morphology and Applied Biology, University of Pisa, Pisa, Italy; 5Laboratory of Bioactive Polymeric Materials for Biomedical and Environmental Applications (BIOlab, UdR INSTM, Department of Chemistry and Industrial Chemistry, University of Pisa, San Piero a Grado, Italy; 6Italian Institute of Technology, Genova, ItalyAbstract: Boron nitride nanotubes (BNNTs have generated considerable interest within the scientific community by virtue of their unique physical properties, which can be exploited in the biomedical field. In the present in vitro study, we investigated the interactions of poly-L-lysine-coated BNNTs with C2C12 cells, as a model of muscle cells, in terms of cytocompatibility and BNNT internalization. The latter was performed using both confocal and transmission electron microscopy. Finally, we investigated myoblast differentiation in the presence of BNNTs, evaluating the protein synthesis of differentiating cells, myotube formation, and expression of some constitutive myoblastic markers, such as MyoD and Cx43, by reverse transcription – polymerase chain reaction and Western blot analysis. We demonstrated that BNNTs are highly internalized by C2C12 cells, with neither adversely affecting C2C12 myoblast viability nor significantly interfering with myotube formation.Keywords: boron nitride nanotubes, C2C12 cells, cytocompatibility, up-take, differentiation, MyoD, connexin 43

  19. Una propuesta de formación de precios para la economía ecológica, mediante un sistema de equilibrio general

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    Montoya Iván A.


    Full Text Available

    Los principales enfoques conceptuales en Economía Ambiental suelen provenir de orientaciones epistemológicas que privilegian el análisis de trade-off entre el empleo marginal de recursos y sus costos de recuperación; sin embargo, dificultan procesos de recurrencia o circularidad como la producción limpia o el empleo de subproductos en un sistema productivo complejo. La utilización de un modelo clásico para la determinación de precios en equilibrio general, originado por los trabajos de Piero Sraffa, puede constituirse en una interesante alternativa conceptual para concebir la formación de precios en un enfoque enriquecido y alterno, que permita incluir la problemática ambiental en el análisis económico, pues facilita la recolección de información sobre la realización de procesos y actividades con recurrencia. El objetivo del documento es proponer un sistema de precios en equilibrio general clásico y sugerir la valoración de bienes y servicios ambientales mediante el uso de rentas diferenciales. La metodología incluye revisión de fuentes bibliográficas, formulación de la pregunta de investigación, identificación de modelos alternativos teóricos relevantes a la pregunta y realización de una propuesta teórica en los términos del objetivo propuesto.

  20. Seasonal nutrient dynamics and biomass quality of giant reed (Arundo donax L. and miscanthus (Miscanthus x giganteus Greef et Deuter as energy crops

    Directory of Open Access Journals (Sweden)

    Nicoletta Nassi o Di Nasso


    Full Text Available The importance of energy crops in displacing fossil fuels within the energy sector in Europe is growing. Among energy crops, the use of perennial rhizomatous grasses (PRGs seems promising owing to their high productivity and their nutrient recycling that occurs during senescence. In particular, nutrient requirements and biomass quality have a fundamental relevance to biomass systems efficiency. The objective of our study was to compare giant reed (Arundo donax L. and miscanthus (Miscanthus × giganteus Greef et Deuter in terms of nutrient requirements and cellulose, hemicelluloses and lignin content. This aim was to identify, in the Mediterranean environment, the optimal harvest time that may combine, beside a high biomass yield, high nutrient use efficiency and a good biomass quality for second generation biofuel production. The research was carried out in 2009, in San Piero a Grado, Pisa (Central Italy; latitude 43°41’ N, longitude 10°21’ E, on seven-year-old crops in a loam soil characterised by good water availability. Maximum above-ground nutrient contents were generally found in summer. Subsequently, a decrease was recorded; this suggested a nutrient remobilisation from above-ground biomass to rhizomes. In addition, miscanthus showed the highest N, P, and K use efficiency, probably related to its higher yield and its C4 pathway. Regarding biomass quality, stable values of cellulose (38%, hemicelluloses (25% and lignin (8% were reported from July onwards in both crops. Hence, these components appear not to be discriminative parameters in the choice of the harvest time in the Mediterranean environment. In conclusion, our results highlighted that, in our environment, a broad harvest period (from late autumn to winter seems suitable for these PRGs. However, further research is required to evaluate the role of rhizomes in nutrient storage and supply during the growing season, as well as ecological and productive performances in marginal

  1. Comparison of two treatments for coxarthrosis: local hyperthermia versus radio electric asymmetrical brain stimulation

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    Castagna A


    Full Text Available Alessandro Castagna1, Salvatore Rinaldi1,2, Vania Fontani1, Piero Mannu1, Matteo Lotti Margotti11Rinaldi Fontani Institute, Department of Neuro Psycho Physio Pathology, 2Medical School of Occupational Medicine, University of Florence, Florence, ItalyBackground: It is well known that psychological components are very important in the aging process and may also manifest in psychogenic movement disorders, such as coxarthrosis. This study analyzed the medical records of two similar groups of patients with coxarthrosis (n = 15 in each who were treated in two different clinics for rehabilitation therapy.Methods: Patients in Group A were treated with a course of traditional physiotherapy, including sessions of local hyperthermia. Group B patients were treated with only a course of radioelectric asymmetrical brain stimulation (REAC to improve their motor behavior.Results: Group A showed a significant decrease in symptoms of pain and stiffness, and an insignificant improvement in range of motion and muscle bulk. A single patient in this group developed worsened symptoms, and pain did not resolve completely in any patient. The patients in Group B had significantly decreased levels of pain and stiffness, and a significant improvement in range of motion and muscle bulk. No patients worsened in Group B, and the pain resolved completely in one patient.Conclusion: Both treatments were shown to be tolerable and safe. Patients who underwent REAC treatment appeared to have slightly better outcomes, with an appreciable improvement in both their physical and mental states. These aspects are particularly important in the elderly, in whom functional limitation is often associated with or exacerbated by a psychogenic component.Keywords: coxarthrosis, anti-aging, motor behavior, radioelectric asymmetric brain stimulation

  2. Therapeutic landscape for ulcerative colitis: where is the Adacolumn® system and where should it be?

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    D’Incà R


    Full Text Available Maurizio Vecchi,1 Piero Vernia,2 Gabriele Riegler,3 Renata D'Incà,4 Vito Annese,5 Siro Bagnoli51University of Milan, Department of Biomedical Sciences for Health, San Donato Milanese, Milan, 2Sapienza University of Rome, Department of Internal Medicine and Medical Specialties, Gastroenterology Unit, Rome, 3Second University of Naples, Gastroenterology and Endoscopy Unit, Naples, 4University of Padua, Department of Surgical and Gastroenterological Science, Gastroenterology Unit, Padua, 5University Hospital Careggi, Gastroenterology Unit, Florence, ItalyAbstract: Granulocyte-monocyte apheresis is a relatively new therapy that has been proposed, sometimes with controversial results, for the treatment of inflammatory bowel disease, particularly ulcerative colitis. The aim of the present study was to perform a thorough review of the literature on the application of this type of treatment in ulcerative colitis and discuss the results, in order to provide an opinion on its use which is shared by the involved experts. The review of the literature was performed by searching PubMed with appropriate key words. The results obtained suggest that the major role for this treatment at this moment is for those patients with steroid dependency or with major contraindications to use of steroids. However, promising, albeit very preliminary, results have also been observed in steroid-naïve subjects, and this is of particular interest in consideration of the safety profile of this therapeutic method. As such, the Adacolumn may prove useful in specific subgroups of patients. Future phenotypic, genotypic, and molecular characterization of patients with inflammatory bowel disease might prove useful in defining better those subjects who might benefit most from this treatment modality.Keywords: ulcerative colitis, inflammatory bowel disease, guidelines, apheresis

  3. Noninvasive brain stimulation by radioelectric asymmetric conveyor in the treatment of agoraphobia: open-label, naturalistic study

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    Mannu P


    Full Text Available Piero Mannu, Salvatore Rinaldi, Vania Fontani, Alessandro Castagna, Matteo Lotti MargottiDepartment of Neuro Psycho Physio Pathology, Rinaldi Fontani Institute, Florence, ItalyBackground: Agoraphobia is considered to be the most serious complication of panic disorder. It involves progressive development of debilitating anxiety symptoms related to being in situations where one would be extremely embarrassed and could not be rescued in the case of a panic attack. This study aimed to investigate the efficacy of noninvasive brain stimulation using a radioelectric asymmetric conveyor (REAC for agoraphobia.Patients and methods: Twenty-three patients (3 males and 20 females suffering from agoraphobia and without a history of panic disorder were evaluated by a psychiatrist using the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision, and the Agoraphobia Scale (AS. The patients were subjected to two 18-session cycles of noninvasive brain stimulation with the REAC, according to an established therapeutic protocol called neuro-psycho-physical optimization.Results: Analyzing the anxiety and avoidance parameters of the AS after the first and second cycles of REAC treatment revealed variation in levels of response to treatment, including weak (AS item 7, moderate (AS items 10 and 13, and good responses (AS items 1–6, 8, 9, 11, 12, and 14–20.Conclusion: These results highlight the potential of the REAC to treat complex clinical situations such as agoraphobia, which is typically resistant to pharmacologic treatments. Furthermore, these data show the advantages of REAC treatment, even compared with modern cognitive behavioral therapy, including a relatively rapid and “stable” clinical response (just over 6 months and economic cost.Keywords: anxiety, avoidance, fear, REAC

  4. [Donatori di Musica: when oncology meets music]. (United States)

    Graiff, Claudio


    Donatori di Musica is a network of musicians - both physicians and volunteers - that was initially founded in 2009 with the aim to set up and coordinate classical music concerts in hospitals. This activity was initially started and led by the Oncology Departments at Carrara and Bolzano Hospitals, where high profile professional musicians make themselves available for concerts in support of Oncological in/out-patients of that specific Hospital. A live classical music performance is a deeply touching experience - particularly for those who live a critical condition like cancer. Main characteristics of Donatori di Musica concerts are: continuity (concerts are part of a regular and non-stopping music season); quality (concerts are held by well-established professional musicians); philanthropic attitude (musicians do not wear a suit and usually chat with patients; they also select an easy-to-listen program; a convivial event is usually organized after the performance with the aim of overcoming distinctions and barriers between physician and patient); no profit: musicians perform for free - travel expenses and/or overnight staying only can be claimed; concerts have free access for patients, their families and hospital staff.Patients and musicians therefore do get in close contact and music is able to merge each other experiences - with patients being treated by the beauty of music and musicians being treated theirselves by patients daily-life feedback. The Donatori di Musica experience is therefore able to help Medicine to retrieve its very first significance - the medical act regain that human and cultural dimension that seems to be abandoned in the last decades in favour of a mere technicism. This is the spirit and the deep significance of Donatori di Musica - «[…] the hope that Music can become a key support to medical treatments in every Oncology department» (by Gian Andrea Lodovici).

  5. Comparative effectiveness of liraglutide in the treatment of type 2 diabetes

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    Rigato M


    Full Text Available Mauro Rigato, Gian Paolo Fadini Department of Medicine, University Hospital of Padova, Padova, Italy Abstract: Type 2 diabetes is characterized by a progressive decline in beta cell function, with consequent worsening of glycemic control. The ideal antihyperglycemic treatment should achieve good and sustained glycemic control, with a low risk of hypoglycemia and no weight gain. This paper reviews the efficacy and tolerability of liraglutide, a glucagon-like peptide-1 receptor agonist approved for the treatment of type 2 diabetes. Once-daily injection of liraglutide (at doses of 1.2 mg and 1.8 mg, as monotherapy or in combination with one or two oral antihyperglycemic agents, was associated with greater improvements in glycemic control compared with active comparators or placebo in several controlled, randomized Phase III trials, including the six trials of the LEAD (Liraglutide Effect and Action in Diabetes program. Liraglutide also improved beta cell function, body weight, systolic blood pressure, and lipid profile, thereby achieving many of the goals of ideal antihyperglycemic therapy. Liraglutide was generally well tolerated in the Phase III trials. The most common adverse events were nausea, vomiting, and diarrhea, usually of mild to moderate intensity. The observed rate of pancreatitis was low and comparable with that of the general diabetic population. In conclusion, although most trials were relatively short and focused on surrogate endpoints, liraglutide emerges as an effective and well tolerated treatment for type 2 diabetes, carrying a low risk of hypoglycemia, weight loss, and possible reduction of cardiovascular risk. Keywords: body weight, hypoglycemia, cardiovascular, incretin

  6. Current trends in the management of ocular symptoms in Adamantiades-Behçet’s disease

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    Fouad R Zakka


    Full Text Available Fouad R Zakka,1 Peter Y Chang,1 Gian P Giuliari,1 C Stephen Foster1,21Massachusetts Eye Research and Surgery institution (MERSI, Cambridge, Massachusetts, USA; 2Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, USAAbstract: Adamantiades-Behçet’s disease (ABD is a multisystemic vasculitic disease. It is most prevalent in the Eastern Mediterranean countries and the Eastern region of Asia. Its effect on the eye can range from mild to debilitating, resulting in total blindness. A necrotizing and obliterative vasculitis affects both arteries and veins of organs. Recurrent attacks of uveitis, oral aphthous ulcers, skin lesions, and genital ulcers are common. Topical and systemic corticosteroids have been the mainstay in the treatment of ocular inflammation for many years; however, due to the several known side effects of corticosteroids and thanks to scientific advances, more novel approaches to ABD treatment have been emerging. Antimetabolites such as methotrexate and azathioprine have been utilized with the latter showing positive results. Chlorambucil has been utilized effectively for ocular manifestations of ABD. Interferon alpha has shown encouraging results in the management of refractory ocular inflammation associated with ABD, either alone or in combination with other immunosuppressive agents. Surgical interventions to deal with complications from ABD can be safely done if adequate control of inflammation is achieved peri-operatively. Early detection and aggressive treatment, when needed, have proven to be essential in the management of this relentlessly explosive disease.Keywords: Adamantiades-Behçet’s disease, Behçet’s disease, ocular inflammation, uveitis, immunomodulatory therapy, immunosuppressive therapy

  7. Thalaikoothal: the Practice of Euthanasia in the Name of Custom

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    Pyali Chatterjee


    Full Text Available Like any other crime, poverty is also one of the main causes of practicing Thalaikoothal. When Pramila Krishan, Journalist of Deccan Chronicale, came to know about the practices of Thalaikoothal, she was very shocked. And while investigating the matter she found that most of the family members use to kill there parents whom they can’t effort. And the aged people of Virudhunagar, they had accepted this practice of getting unnatural death as there fate as they also think that they have become burden for there children, as every thing in today’s world is costly. Article 21 of Indian Constitution grants Right to life only. According to Article 21 says, “No person shall be deprived of his life or personal liberty except according to procedure established by law”. Right life under Article 21 does not include Right to die. Right to life is a natural right. The question regarding Right to die first time comes before Bombay High Court in State of Maharashtra v. Maruty Sripati Dubal 1987 Cri LJ 743. And here in this case court declare that Right to Life includes Right to die, thus making Section 309 of Indian Penal Code, 1860 which makes attempt to suicide as punishable offence unconstitutional. But Supreme Court in Gian Kaur v State of Punjab (19962 SCC 648, held that Right to life does not include “Right to die” or “Right to be killed”. Thus, attempt to suicide is punishable offence under section 309 of Indian Penal Code, 1860 and it is not unconstitutional to Indian Constitution Art. 21. Right to life is a natural right and right to die is not a natural right and no one has a right to finish their life in unnatural way. Thus, the practice of Thalaikoothal is illegal and unethical.

  8. Quantum Nonlocality and Reality (United States)

    Bell, Mary; Gao, Shan


    Preface; Part I. John Stewart Bell: The Physicist: 1. John Bell: the Irish connection Andrew Whitaker; 2. Recollections of John Bell Michael Nauenberg; 3. John Bell: recollections of a great scientist and a great man Gian-Carlo Ghirardi; Part II. Bell's Theorem: 4. What did Bell really prove? Jean Bricmont; 5. The assumptions of Bell's proof Roderich Tumulka; 6. Bell on Bell's theorem: the changing face of nonlocality Harvey R. Brown and Christopher G. Timpson; 7. Experimental tests of Bell inequalities Marco Genovese; 8. Bell's theorem without inequalities: on the inception and scope of the GHZ theorem Olival Freire, Jr and Osvaldo Pessoa, Jr; 9. Strengthening Bell's theorem: removing the hidden-variable assumption Henry P. Stapp; Part III. Nonlocality: Illusions or Reality?: 10. Is any theory compatible with the quantum predictions necessarily nonlocal? Bernard d'Espagnat; 11. Local causality, probability and explanation Richard A. Healey; 12. Bell inequality and many-worlds interpretation Lev Vaidman; 13. Quantum solipsism and non-locality Travis Norsen; 14. Lessons of Bell's theorem: nonlocality, yes; action at a distance, not necessarily Wayne C. Myrvold; 15. Bell non-locality, Hardy's paradox and hyperplane dependence Gordon N. Fleming; 16. Some thoughts on quantum nonlocality and its apparent incompatibility with relativity Shan Gao; 17. A reasonable thing that just might work Daniel Rohrlich; 18. Weak values and quantum nonlocality Yakir Aharonov and Eliahu Cohen; Part IV. Nonlocal Realistic Theories: 19. Local beables and the foundations of physics Tim Maudlin; 20. John Bell's varying interpretations of quantum mechanics: memories and comments H. Dieter Zeh; 21. Some personal reflections on quantum non-locality and the contributions of John Bell Basil J. Hiley; 22. Bell on Bohm Sheldon Goldstein; 23. Interactions and inequality Philip Pearle; 24. Gravitation and the noise needed in objective reduction models Stephen L. Adler; 25. Towards an objective

  9. Omalizumab, an anti-immunoglobulin E antibody: state of the art

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    Incorvaia C


    Full Text Available Cristoforo Incorvaia,1 Marina Mauro,2 Marina Russello,2 Chiara Formigoni,3 Gian Galeazzo Riario-Sforza,1 Erminia Ridolo41Allergy/Pulmonary Rehabilitation, Istituti Clinici di Perfezionamento Hospital, Milan, Italy; 2Allergy Unit, 3Scientific Library, Sant'Anna Hospital, Como, Italy; 4Department of Clinical and Experimental Medicine, University of Parma, Parma, ItalyAbstract: A large number of trials show that the anti-immunoglobulin (Ig E antibody omalizumab is very effective in patients with severe allergic asthma. This is acknowledged in consensus documents. The drug also has a good safety profile and a pharmacoeconomic advantage due to a reduction in the number of hospitalizations for asthma attacks. In recent years, some studies have shown that omalizumab is effective also in nonallergic asthma. Effects on the complex signaling mechanisms leading to activation of effector cells and to mediator release may account for this outcome. Indeed, omalizumab has been reported to be effective in a number of IgE-mediated and non-IgE-mediated disorders. Concerning the former, clinical efficacy has been observed in rhinitis, allergic bronchopulmonary aspergillosis, latex allergy, atopic dermatitis, allergic urticaria, and anaphylaxis. In addition, omalizumab has been demonstrated to be able to prevent systemic reactions to allergen immunotherapy, thus enabling completion of treatment in patients who otherwise would have to stop it. Concerning non-IgE-mediated disorders, omalizumab has been reported to be effective in nasal polyposis, autoimmune urticaria, chronic idiopathic urticaria, physical urticaria, idiopathic angioedema, and mastocytosis. Current indications for treatment with omalizumab are confined to severe allergic asthma. Consequently, any other prescription can only be off-label. However, it is reasonable to expect that the use of omalizumab will be approved for particularly important indications, such as anaphylaxis, in the near future

  10. In depth analysis of motivational factors at work in the health industry

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    Sukhminder Jit Singh Bajwa


    Full Text Available Background: Motivation of health workers is necessary to generate the organizational commitment towards the patients and the hospital and therefore the knowledge about what motivates and satisfies them is very essential.The aim of the project was to investigate and analyze the various factors that help in motivation of the health workers while performing their clinical duties in the hospital. Materials and Methods: A simple random study was conducted among 100 employees of our institute, which included doctors, staff nurses and paramedical staff. One hundred employees from Gian Sagar Institute were chosen randomly for the purpose of our study. All the employees were enquired by the questionnaire method as well as by individual interviews regarding the various motivating and demotivating factors at the work place. Detailed enquiries were performed regarding the various aspects concerning the job factors and work satisfaction. All the answers and findings were observed and recorded. Results: Statistical Analysis Used: Simple non-parametric tests like mean, percentages and chi square tests were employed to analyze the data.The demographic profile of all the employees showed only minor differences which were statistically non-significant. Skills, task identity, task significance, autonomy, feedback, environment, job security and compensation were observed to be the important factors for the motivation of employees. The depth and the extent to which these factors were studied at work in the hospital showed remarkable differences. Conclusion: All the factors studied in this project are essential basis for organizational commitment, but feedback represents the factor with the highest motivation potential especially among the younger population.

  11. Red wine and cardiovascular health the "French Paradox" revisited

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    Giuseppe Lippi


    Full Text Available Giuseppe Lippi1, Massimo Franchini2, Gian Cesare Guidi31U.O. di Diagnostica Ematochimica, 2Servizio di Immunoematologia e Trasfusione, Dipartimento di Patologia e Medicina di Laboratorio, Azienda Ospedaliero, Universitaria di Parma, Parma, Italy; 3Sezione di Chimica Clinica, Dipartimento di Scienze Morfologico-Biomediche, Università degli Studi di Verona, Verona, ItalyAbstract: The healthful and nutritive properties of wine have been acknowledged for thousands of years, but the observation that moderate consumption of red wine on a regular basis may be preventative against coronary disease is recent. Dr Renaud, a scientist working at the Bordeaux University in France, suggested wine consumption explains the “French Paradox”, the low incidence of heart attacks in France regardless of a remarkable dietary intake of saturated fats and alcohol. After nearly 20 years of research, there is now mounting evidence that light to moderate wine intake is beneficial for the cardiovascular health, acting through a variety of mechanisms that target all the crucial steps of atherosclerosis, from early formation of the atherosclerotic plaque to its life-threatening complications (ulceration, thrombosis, vessel occlusion and infarction. These effects are attributable to the synergic properties of several biochemical components of wine (alcohol, resveratrol, and especially polyphenolic compounds, particularly the red varieties. This article reviews the leading clinical observations and the hypothesized biological mechanisms that strongly support the cardiovascular benefits of moderate red wine consumption on cardiovascular health and that would make red wine a promising therapeutic supplement to prevent and even perhaps treat coronary artery disease.Keywords: wine, cardiovascular disease, coronary disease, atherosclerosis

  12. Unihemispheric sleep and asymmetrical sleep: behavioral, neurophysiological, and functional perspectives

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    Mascetti GG


    Full Text Available Gian Gastone Mascetti Department of General Psychology, University of Padova, Padova, Italy Abstract: Sleep is a behavior characterized by a typical body posture, both eyes' closure, raised sensory threshold, distinctive electrographic signs, and a marked decrease of motor activity. In addition, sleep is a periodically necessary behavior and therefore, in the majority of animals, it involves the whole brain and body. However, certain marine mammals and species of birds show a different sleep behavior, in which one cerebral hemisphere sleeps while the other is awake. In dolphins, eared seals, and manatees, unihemispheric sleep allows them to have the benefits of sleep, breathing, thermoregulation, and vigilance. In birds, antipredation vigilance is the main function of unihemispheric sleep, but in domestic chicks, it is also associated with brain lateralization or dominance in the control of behavior. Compared to bihemispheric sleep, unihemispheric sleep would mean a reduction of the time spent sleeping and of the associated recovery processes. However, the behavior and health of aquatic mammals and birds does not seem at all impaired by the reduction of sleep. The neural mechanisms of unihemispheric sleep are unknown, but assuming that the neural structures involved in sleep in cetaceans, seals, and birds are similar to those of terrestrial mammals, it is suggested that they involve the interaction of structures of the hypothalamus, basal forebrain, and brain stem. The neural mechanisms promoting wakefulness dominate one side of the brain, while those promoting sleep predominates the other side. For cetaceans, unihemispheric sleep is the only way to sleep, while in seals and birds, unihemispheric sleep events are intermingled with bihemispheric and rapid eye movement sleep events. Electroencephalogram hemispheric asymmetries are also reported during bihemispheric sleep, at awakening, and at sleep onset, as well as being associated with a use

  13. PREFACE: Dynamic crossover phenomena in water and other glass-forming liquids Dynamic crossover phenomena in water and other glass-forming liquids (United States)

    Chen, Sow-Hsin; Baglioni, Piero


    neutron spin echo measurements, the effect of temperature on dynamic cluster formation of concentrated lysozyme solutions. Xin Li et al explore the use of the newly developed technique of spin echo small angle neutron scattering (SESANS) to investigate the structure of a colloid. They find the SESANS is able to resolve structural heterogeneity, at both intra- and inter-colloidal length scales. The choice of the topics and their elaboration reflects both the diversified current and past research interests of Professor Chen to whom this special section of Journal of Physics: Condensed Matter is dedicated. The issue contains papers from a substantial number of the invited speakers. The papers are arranged in the three categories of water, other glass-forming liquids, and colloids. It is our pleasure to thank all speakers, section chairs and participants who contributed to the great success of the workshop, and to all authors for their additional efforts in preparing their manuscripts. The scientific program of the workshop was organized by Professor Sow-Hsin Chen and Professor Piero Baglioni. The meeting was only possible with the generous financial support of the Consorzio per lo Sviluppo dei Sistemi a Grande Interfase (CSGI) and the University of Florence, Italy. Finally, we express our warmest gratitude to all the members of the local organizing committee and to the staff of the CSGI for all their assistance and great efforts in organizing this meeting. Dynamic crossover phenomena in water and other glass-forming liquids contents Water Neutron spin echo measurements of monolayer and capillary condensed water in MCM-41 at low temperaturesK Yoshida, T Yamaguchi, S Kittaka, M-C Bellissent-Funel and P Fouquet Water dynamics in a lithium chloride aqueous solution probed by Brillouin neutron and x-ray scatteringE Mamontov, A De Francesco, F Formisano, A Laloni, L Sani, B M Leu, A H Said and A I Kolesnikov The dynamical crossover phenomenon in bulk water, confined water and

  14. PREFACE: 12th High-Tech Plasma Processes Conference (HTPP-12) (United States)

    Gleizes, Alain; Ghedini, Emanuele; Gherardi, Matteo; Sanibondi, Paolo; Dilecce, Giorgio


    The High-Tech Plasma Processes - 12th European Plasma Conference (HTPP-12) was held in Bologna (Italy) on 24-29 June 2012. The conference series started in 1990 as a thermal plasma conference and gradually expanded to include other topic fields as well. Now the High-Tech Plasma Processes - European Plasma Conference (HTPP) is a bi-annual international conference based in Europe with topics encompassing the whole area of plasma processing science. The aim of the conference is to bring different scientific communities together, facilitate the contacts between science, technology and industry and provide a platform for the exploration of both fundamental topics and new applications of plasmas. Thanks to the efforts of the conference chairman, Professor Vittorio Colombo and of the co-chair, Professor Piero Favia, a well balanced participation from both the communities of thermal and nonthermal plasma researchers was achieved; this resulted in just about 196 attendees from 39 countries, with 8 plenary and 15 invited talks, plus 50 oral and 140 poster contributions. This volume of Journal of Physics: Conference Series gathers papers from regular contributions of HTPP-12; each contribution submitted for publication has been peer reviewed and the Editors are very grateful to the referees for their careful support in improving the original manuscripts. In the end, 39 manuscripts were accepted for publication, covering different topics of plasma processing science: from plasma fundamentals and modelling to source design and process diagnostics, from nanomaterial synthesis to surface modification, from waste treatment to plasma applications in a liquid environment. It is an honour to present this volume of Journal of Physics: Conference Series and we deeply thank the authors for their enthusiastic and high-grade contribution. Finally, we would like to thank the conference chairmen, the members of the steering committee, the international scientific committee, the local

  15. El partisano Johnny (novela, fragmento

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    Beppe Fenoglio


    Full Text Available GIUSEPPE "BEPPE" FENOGLIO (Alba, 1922 – Turín, 1963. Hijo primogénito de una familia de tres hijos, Beppe nació en Alba en las Langhe el 1 de marzo 1922. En 1940 se inscribe en la facultad de Letras de la Universidad de Turín, en la que estuvo hasta 1943, momento en el que fue reclutado por el ejército y mandado primero a Ceva (Cuneo y después a Pietralata (Roma, donde realizó la instrucción militar. Tras el abandono que siguió al 8 de septiembre de 1943, Fenoglio se une primero en enero de 1944 a las formaciones partisanas. En un primer momento se enrola con los "rojos" de las Brigadas Garibaldi, pero pronto se une a los badogliani en el 1º Gruppo Divisioni Alpine comandado por Enrico Martini "Mauri" y en la 2ª Divisione Langhe comandada por Piero Balbo que operaba en las Langhe, entre Mango, Murazzano y Mombarcaro. En 1949 inicia con su primer cuento, Il trucco, una breve pero fundamental carrera literaria que se afirmará al año siguiente, cuando entre en contacto con el grupo de autores reunidos en torno a la editorial Einaudi, dando a la luz títulos de la altura de Racconti della guerra civile, La paga del sabato, I ventitré giorni della città di Alba o Primavera di belleza. A finales de 1959 se le diagnostica una grave enfermedad respiratoria que se complicará a lo largo de los tres años siguientes y que le causará la muerte en febrero de 1963. De la obra culmen de su carrera, la póstuma Il partigiano Johnny, ofrecemos las páginas iniciales con la estupenda traducción de Pepa Linares, recientemente publicada en castellano por Sajalín Editores. Normal 0 21 false false false ES X-NONE X-NONE  

  16. Economía Política Clásica: el salario de subsistencia y preocupaciones sobre el empleo garantizado

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    John Henrry


    Full Text Available En el marco teórico de la economía política clásica, incluyendo las revisiones de Marx y de los más recientes trabajos de Piero Sraffa y otros, el concepto del salario de subsistencia está entre los más destacados. Aquí, se presenta un recuento de este concepto y se muestra su significado no solamente para la teoría clásica sino también como una preocupación en gran medida social. Argumento que el "salario base" ­como algunas veces se llama­, articulado dentro de un programa de "Empleo Garantizado", es, ­o debería de ser­ comparable con el salario de subsistencia pero requiere de cambios para hacerlo ­aproximadamente­ equivalente. Se demostrará que los seguidores del enfoque clásico no descansaron su teoría de salario sobre un enfoque cuasi-neoclásico de oferta-demanda ­con alguna noción primitiva de productividad marginal detrás de una supuesta demanda de tiempo de trabajo­, pero entendieron los salarios como socialmente determinados ahí donde fuerzas históricas e institucionales establecieron una normativa estándar alrededor de la cual los salarios de mercado gravitaron. Este enfoque fue compartido por, entre otros, Thorstein Veblen y John Maynard Keynes. Una versión de este trabajo fue publicada en ingles: Henry, John (2015 Classical political economy: the subsistence wage and the job guarantee concerns, Journal of Post Keynesian Economics, 38:2, 208-301. La traducción al español, realizada por Eugenia Correa y Wesley Marshall para Ola Financiera, se publica con el permiso de Routledge, Francis and Taylor Group. Una version anterior de este trabajo se presentó en la reunion de la Allied Social Science Association, enero 201 5, bajo los auspicios de la Association for Evolutionary Economics. El autor agradece a los participantes de la sesión sus comentarios, así como especialmente agradece a Mario Seccareccia y Reynold Nesiba.

  17. BOOK REVIEW: Galileo's Muse: Renaissance Mathematics and the Arts (United States)

    Peterson, Mark; Sterken, Christiaan


    Galileo's Muse is a book that focuses on the life and thought of Galileo Galilei. The Prologue consists of a first chapter on Galileo the humanist and deals with Galileo's influence on his student Vincenzo Viviani (who wrote a biography of Galileo). This introductory chapter is followed by a very nice chapter that describes the classical legacy: Pythagoreanism and Platonism, Euclid and Archimedes, and Plutarch and Ptolemy. The author explicates the distinction between Greek and Roman contributions to the classical legacy, an explanation that is crucial for understanding Galileo and Renaissance mathematics. The following eleven chapters of this book arranged in a kind of quadrivium, viz., Poetry, Painting, Music, Architecture present arguments to support the author's thesis that the driver for Galileo's genius was not Renaissance science as is generally accepted but Renaissance arts brought forth by poets, painters, musicians, and architects. These four sets of chapters describe the underlying mathematics in poetry, visual arts, music and architecture. Likewise, Peterson stresses the impact of the philosophical overtones present in geometry, but absent in algebra and its equations. Basically, the author writes about Galileo, while trying to ignore the Copernican controversy, which he sees as distracting attention from Galileo's scientific legacy. As such, his story deviates from the standard myth on Galileo. But the book also looks at other eminent characters, such as Galileo's father Vincenzo (who cultivated music and music theory), the painter Piero della Francesca (who featured elaborate perspectives in his work), Dante Alighieri (author of the Divina Commedia), Filippo Brunelleschi (who engineered the dome of the Basilica di Santa Maria del Fiore in Florence, Johannes Kepler (a strong supporter of Galileo's Copernicanism), etc. This book is very well documented: it offers, for each chapter, a wide selection of excellent biographical notes, and includes a fine

  18. Economic burden of Clostridium difficile in five hospitals of the Florence health care system in Italy

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    Poli A


    Full Text Available Anna Poli,1 Sergio Di Matteo,2 Giacomo M Bruno,2 Enrica Fornai,1 Maria Chiara Valentino,2 Giorgio L Colombo2,31Vigilanza e Controllo Infezioni Correlate all'Assistenza, Ospedale Piero Palagi, Azienda Sanitaria di Firenze, Firenze, Italy; 2SAVE Studi – Health Economics and Outcomes Research, Milan, Italy; 3Department of Drug Sciences, University of Pavia, Pavia, ItalyIntroduction: Despite the awareness about the increasing rates of Clostridium difficile infection (CDI and the economic burden arising from its management (prolonged hospitalization, laboratory tests, visits, surgical treatment, environmental sanitation, few studies are available in Italy on the economic costs directly attributable to the CDI. The Florence health care system has designed a study with the aim of describing the costs attributable to the CDI and defines the incremental economic burden associated with the management of this complication.Methods: We conducted a retrospective study in five hospitals of the Florence health care system. The enrolled population included all patients who were hospitalized during the year 2013 with a diagnosis of CDI. Of the 187 total cases reported in 2013, 69 patients were enrolled, for whom the main cause of hospitalization was directly attributable to CDI.Results: We enrolled 69 patients (19 males and 50 females, with a mean age of 82.16 years (minimum 46 to maximum 98. The total number of hospitalization days observed was 886 (12.8 per patient on average. The data from this study show that the mean total incremental cost for a patient with CDI was €3,270.52 per year. The hospital stay length is the most significant cost parameter, having the largest influence on the overall costs, with an impact of 87% on the total cost. The results confirm the costs for the management of CDI in five hospitals of the Florence health care system are in line with data from the international literature.Conclusion: The economic impact of CDI is most

  19. Cognitive behavioral therapy to aid weight loss in obese patients: current perspectives

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    Castelnuovo G


    Full Text Available Gianluca Castelnuovo,1,2 Giada Pietrabissa,1,2 Gian Mauro Manzoni,1,3 Roberto Cattivelli,1,2 Alessandro Rossi,1 Margherita Novelli,1 Giorgia Varallo,1 Enrico Molinari1,2 1Psychology Research Laboratory, Istituto Auxologico Italiano IRCCS, San Giuseppe Hospital, Verbania, 2Department of Psychology, Catholic University of Milan, Milan, 3Faculty of Psychology, eCampus University, Novedrate, Italy Abstract: Obesity is a chronic condition associated with risk factors for many medical ­complications and comorbidities such as cardiovascular diseases, some types of cancer, osteoarthritis, hypertension, dyslipidemia, hypercholesterolemia, type-2 diabetes, obstructive sleep apnea syndrome, and different psychosocial issues and psychopathological disorders. Obesity is a highly complex, multifactorial disease: genetic, biological, psychological, behavioral, familial, social, cultural, and environmental factors can influence in different ways. Evidence-based strategies to improve weight loss, maintain a healthy weight, and reduce related comorbidities typically integrate different interventions: dietetic, nutritional, physical, behavioral, psychological, and if necessary, pharmacological and surgical ones. Such treatments are implemented in a multidisciplinary context with a clinical team composed of endocrinologists, nutritionists, dietitians, physiotherapists, psychiatrists, psychologists, and sometimes surgeons. Cognitive behavioral therapy (CBT is traditionally recognized as the best established treatment for binge eating disorder and the most preferred intervention for obesity, and could be considered as the first-line treatment among psychological approaches, especially in a long-term perspective; however, it does not necessarily produce a successful weight loss. Traditional CBT for weight loss and other protocols, such as enhanced CBT, enhanced focused CBT, behavioral weight loss treatment, therapeutic education, acceptance and commitment therapy

  20. Use of oral contraceptives in the management of acne

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    Melis GB


    Full Text Available Gian Benedetto Melis, Marisa Orrù, Maria Francesca Marotto, Monica Pilloni, Mariagrazia Perseu, Stefano Lello, Anna Maria PaolettiClinica Ginecologica Ostetrica e di Fisiopatologia della Riproduzione Umana, Universita' di Cagliari, Azienda Ospedaliero Universitaria di Cagliari, Cagliari, ItalyAbstract: The pathogenesis of acne (the most common disorder involving the sebaceous gland originates from increased sebum production by the sebaceous gland followed by colonization of the hair follicle with Propionibacterium acnes, hyperkeratinization of the upper follicle, and release of inflammatory mediators into the skin. Androgens are the main stimulators of sebum production. Androgens originate from the gonads and adrenal glands, but can also be locally produced within the sebaceous gland from dehydroepiandrosterone sulfate. In the presence of high androgen levels, which can be either a normal pattern of adolescence or a consequence of gonadal or adrenal disease, overproduction of sebum triggers the pathogenesis of acne which, mainly in adolescent women, has deleterious psychological consequences. Estrogens exert the opposite action on sebum production, probably due to the reduction of androgen availability, a direct consequence of estrogen-related increased production of hepatic sex hormone-binding globulin (SHBG. The inhibition of the hypothalamus-pituitary axis induced by oral contraceptives is followed by reduced androgen production. Oral contraceptives containing ethinyl estradiol, which has strong estrogenic activity, amplify the hypoandrogenic effect via estrogen-related stimulation of SHBG. The hypoandrogenic effect of oral contraceptives is modulated by the progestin compound. Progestins derived from 19-nortestosterone bind androgenic receptors, whereas others exert antiandrogenic properties by antagonizing the binding of androgens to their receptors, reduce 5α-reductase, and do not bind SHBG. Through this last effect, SHBG is freely

  1. Fictional Marriage Proposal of Anonymous Astrakhan Khan

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    Roman Hautala


    Full Text Available The following text is reproduced from a handwritten copy of the letter made by the Italian humanist Gian Vincenzo Pinelli (1535–1601 and contained in one codex of Ambrosiana Library in Milan (R 104 sup., fol. 194r [see the description of the codex in: 3, no. 341. p. 125]. This codex (588 folios contains Italian and Latin texts of the 16th century of extremely diverse content, which does not allow to determe neither the name of the author of the reproduced letter, nor the date of its writing. Nevertheless, a reference to the name of “Luther” in the letter suggests that it must have been written in the 16th century and an indication of the main purpose of the letter – matchmaking to anonymous queen – makes it possible to put forward quite a bold (but, for now, unproven hypothesis that this letter might be addressed to approximates of the Polish Queen Bona Sforza and the widow of King Sigismund I the Old starting with the April 1, 1548. Following this hypothesis, the alleged author of the letter could be the ruler of Astrakhan Yamgurchi or the Crimean khan Sahib Giray. However, this assumption remains only a hypothesis, and the author of this article hopes that future researchers will be able to identify both the author of the letter and its recipients. Be that as it may, this letter is of undoubtedly fictitious character since it does not indicate the name of its author and the date of writing and obviously differs from official form of the Tatar rulers’ letters. Undoubtedly, this letter refers to the literary genre of fictional letters of the rulers, which became extremely popular in Europe since the second half of the 15th century. As an illustration of this genre, the author of this article presents a “letter” of the Turkish sultan to the Tatars and their “response” from the fictional collection of “Letters of the Great Turk” [1, fol. 18r] of Laudivius Hierosolymitanus, which was a relatively widespread in Europe in the

  2. Differential renal adverse effects of ibuprofen and indomethacin in preterm infants: a review

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    Pacifici GM


    Full Text Available Gian Maria Pacifici Medical School, Department of Translational Research and New Technologies in Medicine and Surgery, Section of Pharmacology, University of Pisa, Pisa, Italy Objective: The objective of this study was to evaluate the extent of renal adverse effects caused by ibuprofen or indomethacin in order to choose the safer drug to administer to preterm infants. Methods: The following three parameters of renal function were taken into consideration: 1 the urine output; 2 the serum creatinine concentration; and 3 the frequency of oliguria. The bibliographic search was performed using PubMed and Embase databases as search engines. Results: Urine output ranged from 3.5±1.2 to 4.0±1.4 mL/kg/h after ibuprofen treatment, and from 2.8±1.1 to 3.6±1.4 mL/kg/h after indomethacin treatment. The values for ibuprofen are significantly (P<0.05 higher than those for indomethacin. The serum creatinine concentrations ranged from 0.98±0.24 to 1.48±0.2 mg/dL after ibuprofen treatment, and from 1.06±0.24 and 2.03±2.10 mg/dL after indomethacin treatment. The values for ibuprofen are significantly (P<0.05 lower than those for indomethacin. The frequency of oliguria ranged from 1.0% to 9.6% (ibuprofen and from 14.8% to 40.0% (indomethacin, and was significantly lower following ibuprofen than indomethacin administration. In infants with body weight lower than 1,000 g, oliguria appeared in 5% (ibuprofen and 40% (indomethacin; P=0.02. Conclusion: Indomethacin is associated with more severe renal adverse effects than ibuprofen. Ibuprofen is less nephrotoxic than indomethacin and should be used to treat patent ductus arteriosus in preterm infants. Immaturity increases the frequency of adverse effects of indomethacin. Keywords: ibuprofen, indomethacin, patent-ductus-arteriosus, renal-side-effects

  3. Comparison between parameters of muscle performance and inflammatory biomarkers of non-sarcopenic and sarcopenic elderly women

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    Lustosa LP


    Full Text Available Lygia Paccini Lustosa,1 Patrícia Parreira Batista,1 Daniele Sirineu Pereira,2 Leani Souza Máximo Pereira,1 Aline Scianni,1 Giane Amorim Ribeiro-Samora1 1Physical Therapy Department, Universidade Federal de Minas Gerais, Belo Horizonte, 2Physical Therapy Department, Universidade Federal de Alfenas, Alfenas, Brazil Background: Sarcopenia is a multifactorial geriatric syndrome with complex interrelationships. Increased plasma levels of inflammatory mediators increase the catabolic stimuli of the musculature, thereby causing a decrease in mass and muscular function. Objective: The objective of this study was to compare the performance of the knee extensors test (by isokinetic dynamometer and plasma levels of interleukin-6 (IL-6 and soluble receptors of tumor necrosis factor alpha (sTNFR1 between sarcopenics and non-sarcopenics community-dwelling elderly women residents of Brazil. Material and methods: The diagnosis of sarcopenia included measurements of body composition (by densitometry with dual energy source of X-ray, handgrip strength (by Jamar® dynamometer, and the usual gait velocity according to the recommendations of the European Working Group on Sarcopenia in Older People. In both sarcopenics and non-sarcopenics elderly women, we evaluated the muscle function by knee extensors test (using an isokinetic dynamometer Byodex System 4 Pro® at angular speeds of 60°/s and 180°/s and also we evaluated the plasma concentrations of IL-6 and sTNFR1. Comparisons of muscle performance between groups were carried out using mixed factorial ANOVA with post hoc Bonferroni test; sTNFR1 and IL-6 variables were analyzed by applying Mann–Whitney U test. Results: Statistical differences were observed between groups regarding muscle power (P=0.01, total work adjusted to body weight (P=0.01 at a rate of 180°/s, and plasma levels of sTNFR1 (P=0.01. Conclusion: Sarcopenic elder women showed lower performance of the lower limbs, especially at a higher speed

  4. [Exploring life-experience of the staff and volunteers assisting pediatric patients in end-of-life situations] [Article in Italian] • I vissuti dello staff e dei volontari che assistono pazienti pediatrici terminali

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    Rosapia Lauro Grotto


    philosophical approaches to the issues raised by palliative care in paediatric settings.Articoli Selezionati del Congresso “Medicina Narrativa e Comunicazione nella Pratica Clinica” ·  Cagliari · 14 Aprile 2014 Guest Editors: Massimiliano Zonza, Vassilios Fanos, Gian Paolo Donzelli

  5. Fat-free mass change after nutritional rehabilitation in weight losing COPD: role of insulin, C-reactive protein and tissue hypoxia

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    Simonetta Baldi


    Full Text Available Simonetta Baldi, Roberto Aquilani, Gian Domenico Pinna, Paolo Poggi, Angelo De Martini, Claudio BruschiDepartment of Pneumology and Biomedical Engineering, Scientific Institute of Montescano, Salvatore Maugeri Foundation I.R.C.C.S. Pavia, ItalyBackground: Fat-free mass (FFM depletion marks the imbalance between tissue protein synthesis and breakdown in chronic obstructive pulmonary disease (COPD. To date, the role of essential amino acid supplementation (EAAs in FFM repletion has not been fully acknowledged. A pilot study was undertaken in patients attending pulmonary rehabilitation.Methods: 28 COPD patients with dynamic weight loss > 5% over the last 6 months were randomized to receive EAAs embedded in a 12-week rehabilitation program (EAAs group n = 14, or to the same program without supplementation (C group n = 14. Primary outcome measures were changes in body weight and FFM, using dual X-ray absorptiometry (DEXA.Results: At the 12th week, a body weight increment occurred in 92% and 15% of patients in the EAAs and C group, respectively, with an average increase of 3.8 ± 2.6 kg (P = 0.0002 and −0.1 ± 1.1 kg (P = 0.81, respectively. A FFM increment occurred in 69% and 15% of EAAs and C patients, respectively, with an average increase of 1.5 ± 2.6 kg (P = 0.05 and −0.1 ± 2.3 kg (P = 0.94, respectively. In the EAAs group, FFM change was significantly related to fasting insulin (r2 0.68, P < 0.0005, C-reactive protein (C-RP (r2 = 0.46, P < 0.01, and oxygen extraction tension (PaO2x (r2 = 0.46, P < 0.01 at end of treatment. These three variables were highly correlated in both groups (r > 0.7, P < 0.005 in all tests.Conclusions: Changes in FFM promoted by EAAs are related to cellular energy and tissue oxygen availability in depleted COPD. Insulin, C-RP, and PaO2x must be regarded as clinical markers of an amino acid-stimulated signaling to FFM accretion.Keywords: COPD, pulmonary rehabilitation, branched chain amino acids, insulin, systemic

  6. CR4056, a new analgesic I2 ligand, is highly effective against bortezomib-induced painful neuropathy in rats

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    Meregalli C


    Full Text Available Cristina Meregalli,1 Cecilia Ceresa,1 Annalisa Canta,1 Valentina Alda Carozzi,1 Alessia Chiorazzi,1 Barbara Sala,1 Norberto Oggioni,1 Marco Lanza,2 Ornella Letar,i2 Flora Ferrari,2 Federica Avezza,1 Paola Marmiroli,1 GianFranco Caselli,2 Guido Cavaletti11Department of Neuroscience and Biomedical Technologies, University of Milan-Bicocca, 2Pharmacology and Toxicology Department, Rottapharm | Madaus Research Center, Monza, ItalyAbstract: Although bortezomib (BTZ is the frontline treatment for multiple myeloma, its clinical use is limited by the occurrence of painful peripheral neuropathy, whose treatment is still an unmet clinical need. Previous studies have shown chronic BTZ administration (0.20 mg/kg intravenously three times a week for 8 weeks to female Wistar rats induced a peripheral neuropathy similar to that observed in humans. In this animal model of BTZ-induced neurotoxicity, the present authors evaluated the efficacy of CR4056, a novel I2 ligand endowed with a remarkable efficacy in several animal pain models. CR4056 was administered in a wide range of doses (0.6–60 mg/kg by gavage every day for 2–3 weeks in comparison with buprenorphine (Bupre (28.8 µg/kg subcutaneously every day for 2 weeks and gabapentin (Gaba (100 mg/kg by gavage every day for 3 weeks. Chronic administration of BTZ reduced nerve conduction velocity and induced allodynia. CR4056, Bupre, or Gaba did not affect the impaired nerve conduction velocity. Conversely, CR4056 dose-dependently reversed BTZ-induced allodynia (minimum effective dose 0.6 mg/kg. The optimal dose found, 6 mg/kg, provided a constant pain relief throughout the treatment period and without rebound after suspension, being effective when coadministered with BTZ, starting before or after allodynia was established, or when administered alone after BTZ cessation. A certain degree of tolerance was seen after 7 days of administration, but only at the highest doses (20 and 60 mg/kg. Bupre was effective

  7. In children allergic to ragweed pollen, nasal inflammation is not influenced by monosensitization or polysensitization

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    Gelardi M


    Full Text Available Matteo Gelardi,1 Mariangela Bosoni,2 Marco Morelli,2 Silvia Beretta,2 Cristoforo Incorvaia,3 Serena Buttafava,4 Massimo Landi,5 Simonetta Masieri,6 Franco Frati,4 Nicola Quaranta,1 Gian Vincenzo Zuccotti21Otolaryngology Section, Department of Neuroscience and Sensory Organs, University of Bari, 2Department of Pediatrics, Luigi Sacco Hospital, University of Milan, 3Allergy/Pulmonary Rehabilitation Unit, ICP Hospital, 4Medical and Scientific Department, Stallergenes Italy, Milan, 5Department of Pediatrics, ASL TO1, Turin, 6Department of Otorhinolaryngology, Sapienza University of Rome, Rome, ItalyBackground: In patients polysensitized to pollen allergens, the priming effect, by which the sensitivity of the nasal mucosa to an allergen is increased by the previous exposure to another allergen, is a known phenomenon. This study was aimed at evaluating the degree of nasal inflammation, assessed by nasal cytology, in children with allergic rhinitis (AR from ragweed pollen according to being monosensitized or polysensitized.Methods: The study included 47 children. Of them, 24 suffered from AR caused by sensitization to grass pollen and ragweed pollen (group A and 23 were sensitized only to ragweed pollen (group B. In all patients, the severity of AR was assessed according to the Allergic Rhinitis and Its Impact on Asthma guidelines, and comorbidities were also evaluated.Results: In group A, 16.7% of children had a mild intermittent AR, 4.2% a moderate-to-severe intermittent, 33.3% a mild persistent, and 45.8% a moderate-to-severe persistent; in group B, 26.1% of children had a mild intermittent AR, 0% a moderate-to-severe intermittent, 52.2% a mild persistent, and 21.7% a moderate-to-severe persistent. No significant difference was detected in the number of the considered comorbidities between the two groups. The cell counts of neutrophils, eosinophils, lymphocytes/plasma cells, and mast cells were high but not significantly different in the two groups

  8. Nanoparticle-based delivery of small interfering RNA: challenges for cancer therapy

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    Miele E


    Full Text Available Evelina Miele,1,* Gian Paolo Spinelli,2,* Ermanno Miele,3 Enzo Di Fabrizio,3,6 Elisabetta Ferretti,4 Silverio Tomao,2 Alberto Gulino,1,5 1Department of Molecular Medicine, 2Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Rome, 3Nanostructures, Istituto Italiano di Tecnologia, via Morego, 30, 16163 Genova, 4Department of Experimental Medicine, Sapienza University of Rome, Rome, 5Center for Life Nanoscience, Istituto Italiano di Tecnologia, Rome, Italy, 6BIONEM lab, University of Magna Graecia, Campus S. Venuta, Viale Europa 88100 Catanzaro, Italy *These authors contributed equally to this workAbstract: During recent decades there have been remarkable advances and profound changes in cancer therapy. Many therapeutic strategies learned at the bench, including monoclonal antibodies and small molecule inhibitors, have been used at the bedside, leading to important successes. One of the most important advances in biology has been the discovery that small interfering RNA (siRNA is able to regulate the expression of genes, by a phenomenon known as RNA interference (RNAi. RNAi is one of the most rapidly growing fields of research in biology and therapeutics. Much research effort has gone into the application of this new discovery in the treatment of various diseases, including cancer. However, even though these molecules may have potential and strong utility, some limitations make their clinical application difficult, including delivery problems, side effects due to off-target actions, disturbance of physiological functions of the cellular machinery involved in gene silencing, and induction of the innate immune response. Many researchers have attempted to overcome these limitations and to improve the safety of potential RNAi-based therapeutics. Nanoparticles, which are nanostructured entities with tunable size, shape, and surface, as well as biological behavior, provide an ideal opportunity to modify current

  9. Long-term survival in elderly patients with a do-not-intubate order treated with noninvasive mechanical ventilation

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    Riario-Sforza GG


    Full Text Available Paolo Scarpazza1, Cristoforo Incorvaia2, Paolo Amboni3, Giuseppe di Franco1, Stefania Raschi1, Pierfranco Usai1, Monica Bernareggi1, Cristiano Bonacina1, Chiara Melacini1, Roberta Cattaneo1, Serena Bencini1, Chiara Pravettoni2, Gian Galeazzo Riario-Sforza2, Gianni Passalacqua4, Walter Casali11Divisione di Broncopneumotisiologia, Ospedale Civile, Vimercate, Italy; 2Pulmonary Rehabilitation, Istituti Clinici di Perfezionamento, Milan, Italy; 3Clinical Chemistry Laboratory, Ospedali Riuniti, Bergamo, Italy; 4Allergy and Respiratory Diseases, University Of Genoa, Genoa, ItalyBackground: Noninvasive mechanical ventilation (NIMV is an effective tool in treating patients with acute respiratory failure (ARF, since it reduces both the need for endotracheal intubation and the mortality in comparison with nonventilated patients. A particular issue is represented by the outcome of NIMV in patients referred to the emergency department for ARF and with a do-not-intubate (DNI status because of advanced age or excessively critical conditions. This study evaluated long-term survival in a group of elderly patients with acute hypercapnic ARF who had a DNI order and who were successfully treated by NIMV.Methods: The population consisted of 54 patients with a favorable outcome after NIMV for ARF. They were followed up for 3 years by regular control visits, with at least one visit every 4 months, or as needed according to the patient’s condition. Of these, 31 continued NIMV at home and 23 were on long-term oxygen therapy (LTOT alone.Results: A total of 16 of the 52 patients had not survived at the 1-year follow-up, and another eight patients died during the 3-year observation, with an overall mortality rate of 30.8% after 1 year and 46.2% after 3 years. Comparing patients who continued NIMV at home with those who were on LTOT alone, 9 of the 29 patients on home NIMV died (6 after 1 year and 3 after 3 years and 15 of the 23 patients on LTOT alone died (10 after 1

  10. Effect of noninvasive mechanical ventilation in elderly patients with hypercapnic acute-on-chronic respiratory failure and a do-not-intubate order

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    Paolo Scarpazza


    Full Text Available Paolo Scarpazza1, Cristoforo Incorvaia2, Giuseppe di Franco1, Stefania Raschi1, Pierfranco Usai1, Monica Bernareggi1, Cristiano Bonacina1, Chiara Melacini1, Silvia Vanni1, Serena Bencini1, Chiara Pravettoni2, Giuseppe Di Cara3, Mona-Rita Yacoub4, Gian Galeazzo Riario-Sforza2, Enrico Guffanti5, Walter Casali11Divisione di Broncopneumotisiologia, Ospedale Civile, Vimercate, Italy; 2Pulmonary rehabilitation, Istituti Clinici di Perfezionamento, Milan, Italy; 3University Department of Medical and Surgical Specialties and Public Health, Perugia, Italy; 4Allergy and Immunology Unit, IRCCS San Raffaele Hospital, Milan, Italy; 5Pulmonary rehabilitation, INRCA, Casatenovo, ItalyAbstract: Noninvasive mechanical ventilation (NIMV is effective in the treatment of patients with acute respiratory failure (ARF. It proved to reduce the need of endotracheal intubation (ETI, the incidence of ETI-associated pneumonia, and mortality compared to nonventilated patients. A particular aspect concerns the outcome of NIMV in patients referring to an emergency room (ER for ARF, and with a do-not-intubate (DNI status due to advanced age or critical conditions. The aim of our study is to assess the outcome of NIMV in a group of elderly patients with acute hypercapnic ARF who had a DNI status. An overall number of 62 subjects (30 males, 32 females, mean age 81 ± 4.8 years, range 79–91 years referred to our semi-intensive respiratory department were enrolled in the study. The underlying diseases were severe chronic obstructive pulmonary disease (COPD in 50/62 subjects, restrictive thoracic disorders in 7/62 subjects, and multiorgan failure in 5/62 subjects. Fifty-four/62 patients were successfully treated with NIMV while 2/62 did not respond to NIMV and were therefore submitted to ETI (one survived. Among NIMV-treated patients, death occurred in 6 patients after a mean of 9.9 days; the overall rate of NIMV failure was 12.9%. Negative prognostic factors for NIMV response

  11. Medicinal clays improve the endurance of loaded inspiratory muscles in COPD: a randomized clinical trial of nonpharmacological treatment

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    Baldi S


    Full Text Available Simonetta Baldi,1 Gian Domenico Pinna,2 Claudio Bruschi,1 Fabrizio Caldara,3 Roberto Maestri,2 Elena Dacosto,1 Antonella Rezzani,1 Ermanno Popovich,1 Ezio Bellinzona,1 Paola Crotti,1 Silvia Montemartini,1 Claudio Fracchia1 1Department of Pneumology, 2Department of Biomedical Engineering, Scientific Institute of Montescano, Salvatore Maugeri Foundation, Istituto Di Ricovero e Cura a Carattere Scientifico, Montescano (Pavia, 3Center of Thermal Studies Pietro d’Abano, AbanoTerme, Padua, Italy Background: Inspiratory resistive breathing (IRB challenges affect respiratory muscle endurance in healthy individuals, which is considered to be an interleukin 6 (IL-6–dependent mechanism. Whether nonpharmacological thermal therapies promote the endurance of loaded inspiratory muscles in chronic obstructive pulmonary disease (COPD is unclear. The objectives of this study were to compare the effects of two thermal interventions on endurance time (ET and plasma IL-6 concentration following an IRB challenge.Methods: This study was a randomized, parallel-group, unblinded clinical trial in a single-center setting. Forty-two patients (aged 42–76 years suffering from mild to severe COPD participated in this study. Both groups completed 12 sessions of the mud bath therapy (MBT (n=22 or leisure thermal activity (LTA (n=19 in a thermal spa center in Italy. Pre- and postintervention spirometry, maximum inspiratory pressure, and plasma mediators were obtained and ET and endurance oxygen expenditure (VO2Endur were measured following IRB challenge at 40% of maximum inspiratory pressure.Results: There was no difference in ΔIL-6 between the intervention groups. But, IRB challenge increased cytokine IL-6 plasma levels systematically. The effect size was small. A statistically significant treatment by IRB challenge effect existed in ET, which significantly increased in the MBT group (P=0.003. In analysis of covariance treatment by IRB challenge analysis with LnVO2

  12. Book reviews

    Directory of Open Access Journals (Sweden)

    Redactie KITLV


    Full Text Available -Jay B. Haviser, Jerald T. Milanich ,First encounters: Spanish explorations in the Caribbean and the United States, 1492-1570. Gainesville FL: Florida Museum of Natural History & University Presses of Florida, 1989. 221 pp., Susan Milbrath (eds -Marvin Lunenfeld, The Libro de las profecías of Christopher Columbus: an en face edition. Delano C. West & August Kling, translation and commentary. Gainesville FL: University of Florida Press, 1991. x + 274 pp. -Suzannah England, Charles R. Ewen, From Spaniard to Creole: the archaeology of cultural formation at Puerto Real, Haiti. Tuscaloosa AL; University of Alabama Press, 1991. xvi + 155 pp. -Piero Gleijeses, Bruce Palmer Jr., Intervention in the Caribbean: the Dominican crisis of 1965. Lexington KY: University Press of Kentucky, 1989. -Piero Gleijeses, Herbert G. Schoonmaker, Military crisis management: U.S. intervention in the Dominican Republic, 1965. Westport CT: Greenwood Press, 1990. 152 pp. -Jacqueline A. Braveboy-Wagner, Fitzroy André Baptiste, War, cooperation, and conflict: the European possessions in the Caribbean, 1939-1945. Westport CT: Greenwood Press, 1988. xiv + 351 pp. -Peter Meel, Paul Sutton, Europe and the Caribbean. London: Macmillan Caribbean, 1991. xii + 260 pp. -Peter Meel, Betty Secoc-Dahlberg, The Dutch Caribbean: prospects for democracy. New York: Gordon and Breach, 1990. xix + 333 pp. -Michiel Baud, Rosario Espinal, Autoritarismo y democracía en la política dominicana. San José, Costa Rica: Ediciones CAPEL, 1987. 208 pp. -A.J.G. Reinders, J.M.R. Schrils, Een democratie in gevaar: een verslag van de situatie op Curacao tot 1987. Assen, Maastricht: Van Gorcum, 1990. xii + 292 pp. -Andrés Serbin, David W. Dent, Handbook of political science research on Latin America: trends from the 1960s to the 1990s. Westport CT: Greenwood, 1990. -D. Gail Saunders, Dean W. Collinwood, The Bahamas between worlds. Decatur IL: White Sound Press, 1989. vii + 119 pp. -D. Gail Saunders, Dean

  13. Época de poda da figueira cultivada no estado de São Paulo Pruning time for fig trees in the state of São Paulo

    Directory of Open Access Journals (Sweden)

    Orlando Rigitano


    Full Text Available No Estado de São Paulo as figueiras (Ficus carica L. são anualmente submetidas a um tipo de poda hibernal que consiste na eliminação quase total da copa formada na estação anterior. Com a finalidade de estudar o comportamento de figueiras podadas em diferentes épocas durante o inverno, foi iniciado em 1960, em Campinas, um experimento com cinco épocas de poda no período de 1.° de maio a 1.° de setembro. São apresentados os dados de produção, por tratamento obtidos em 1962 e 1963, relativos ao número e ao pêso de figos, assim como os pesos médios de uma fruta. Os dados de 1963, revelaram diferenças significativas e permitiram várias conclusões. A poda feita em 1.° de agôsto ofereceu os melhores resultados, embora sem diferir significativamente daquela executada em 1.° de julho. Como era esperado, as podas levadas a efeito nas épocas extremas, isto é, em princípios de maio e de setembro, resultaram nas produções mais baixas. Observou-se tendência da obtenção de colheitas mais precoces e figos mais pesados nos tratamentos mais produtivos.With a view to compare the effects on fruit bearing, pruning of fig trees was carried out in Campinas, State of São Paulo, during the dormant season of the plant, at 5 different dates, namely on the 1st day of each of the months of May, June, July, August and September. Pruning was started as soon as the plants became more or less dormant in the fall and was continued until vegetation again appeared at the end of winter. The pruning operation took place for two following years and at the dates mentioned all the new branches were cut back to short stubs. The experimental plot consisted of 30 trees of the variety "Roxo de Valinhos" (San Piero spread apart 7 by 13 feet and was laid out in randomized blocks with 3 replications. The results of this trial can be summarized as follows: a Trees pruned on August 1st gave the highest yield followed by those pruned on July 1st. While the

  14. An innovative intervention for the treatment of cognitive impairment–Emisymmetric bilateral stimulation improves cognitive functions in Alzheimer’s disease and mild cognitive impairment: an open-label study

    Directory of Open Access Journals (Sweden)

    Guerriero F


    Full Text Available Fabio Guerriero,1–3 Emanuele Botarelli,3 Gianni Mele,3 Lorenzo Polo,3 Daniele Zoncu,3 Paolo Renati,3,4 Carmelo Sgarlata,1 Marco Rollone,2 Giovanni Ricevuti,1,2 Niccolo Maurizi,1 Matthew Francis,1 Mariangela Rondanelli,5 Simone Perna,5 Davide Guido,2,6 Piero Mannu3 1Department of Internal Medicine and Medical Therapy, Section of Geriatrics, University of Pavia, Pavia, Italy; 2Agency for Elderly People Services, Santa Margherita Hospital, Pavia, Italy; 3Ambra Elektron, Italian Association of Biophysics for the Study of Electromagnetic Fields in Medicine, 4Alberto Sorti Research Institute, Medicine and Metamolecular Biology, Turin, Italy; 5Department of Public Health, Experimental and Forensic Medicine, Section of Human Nutrition, Endocrinology and Nutrition Unit, 6Department of Public Health, Experimental and Forensic Medicine, Biostatistics and Clinical Epidemiology Unit, University of Pavia, Pavia, Italy Background and aims: In the last decade, the development of different methods of brain stimulation by electromagnetic fields (EMF provides a promising therapeutic tool for subjects with impaired cognitive functions. Emisymmetric bilateral stimulation (EBS is a novel and innovative EMF brain stimulation, whose working principle is to introduce very weak noise-like stimuli through EMF to trigger self-arrangements in the cortex of treated subjects, thereby improving cognitive faculties. The aim of this pilot study was to investigate in patients with cognitive impairment the effectiveness of EBS treatment with respect to global cognitive function, episodic memory, and executive functions. Methods: Fourteen patients with cognitive decline (six with mild cognitive impairment and eight with Alzheimer’s disease underwent three EBS applications per week to both the cerebral cortex and auricular-specific sites for a total of 5 weeks. At baseline, after 2 weeks and 5 weeks, a neuropsychological assessment was performed through mini–mental state

  15. Early bronchodilator action of glycopyrronium versus tiotropium in moderate-to-severe COPD patients: a cross-over blinded randomized study (Symptoms and Pulmonary function in the moRnING

    Directory of Open Access Journals (Sweden)

    Marin JM


    Full Text Available Jose M Marin,1 Kai M Beeh,2 Andreas Clemens,3 Walter Castellani,4 Lennart Schaper,5 Dinesh Saralaya,6 Anthony Gunstone,7 Ricard Casamor,8 Konstantinos Kostikas,3 Maryam Aalamian-Mattheis3 1University Hospital Miguel Servet, IISAragón, CIBERES, Zaragoza, Spain; 2Insaf Respiratory Research Institute, Wiesbaden, Germany; 3Novartis Pharma AG, Basel, Switzerland; 4Hospital Piero Palagi, Fiorenze, Italy; 5Research Institute and Practice, Berlin-Brandenburg, Germany; 6Bradford Teaching Hospitals NHS Foundation Trust, Bradford, UK; 7Staploe Medical Center, Soham, Cambridge, UK; 8Novartis Farmaceutica SA, Barcelona, Spain Background: Morning symptoms associated with COPD have a negative impact on patients’ quality of life. Long-acting bronchodilators with rapid onset may relieve patients’ symptoms. In the Symptoms and Pulmonary function in the moRnING study, we prospectively compared the rapid onset bronchodilator profile of glycopyrronium (GLY and tiotropium (TIO during the first few hours after dosing in patients with moderate-to-severe COPD.Methods: Patients were randomized (1:1 to receive either once-daily GLY (50 µg or TIO (18 µg and corresponding placebos in a cross-over design for 28 days. The primary objective was to demonstrate the superiority of GLY versus TIO in area under the curve from 0 to 4 hours (AUC0-4h forced expiratory volume in 1 second (FEV1 after the first dose. The secondary objective was to compare GLY versus TIO using the patient reported outcomes Morning COPD Symptoms Questionnaire 3 hours post-inhalation.Results: One-hundred and twenty-six patients were randomized (male 70.2%; mean age 65.7 years and 108 patients completed the study. On Day 1, GLY resulted in significantly higher FEV1 AUC0-4h after the first dose versus TIO (treatment difference [Δ], 0.030 L, 95% confidence interval 0.004–0.056, P=0.025. Improvements in morning COPD symptoms from baseline at Days 1 and 28 were similar between GLY and TIO. Post hoc

  16. La décoration de Pierre en relief entre le bas empire et les débuts de Byzancedans les vestiges de la cité de Duklja (Doclea

    Directory of Open Access Journals (Sweden)

    Korać Vojislav


    Full Text Available (francuski Les vestiges d’une cité antique se trouvant près de Podgorica au Monténégro attiraient l’attention par leur situation et leurs dimensions. Des connaissances historiques modestes évoluaient entre le fait incontestable qu’il s’agit d’une cité antique abandonnée au moment des grandes migrations des populations dans la région. Le matériel dans les vestiges de la cité, surtout du marbre et de la pierre, a été dilapidé selon les besoins de la population de la région plus ou moins proche. Des recherches sérieuses ont été amorcées selon le désir formel du roi Nicolas. Sur les vestiges de Doclea plusieurs groupes d’archéologues russes ou anglais ont travaillé. Des recherches plus approfondies ont été publiées par Piero Sticcoti, son livre a été traduit et la traduction suivie du texte de Olivera Velimirovic Zizic expliquant la valeur du livre. Le besoin de nouvelles recherches de fond se faisant sentir l’Institut de la conservation des monuments de culture de la république du Monténégro et l’Institut d’archéologie à Belgrade se sont mis d’accord sur la poursuite des recherches en trois campagnes - en 1954, en 1955 et en 1966. Les dernières recherches ont apporté de nouvelles informations en abondance sur ce site archéologique exceptionnel. L’examen des reliefs en pierre reposait surtout sur celui des chapiteaux. Tout en étant en mauvais état ils ont cependant donné l’information sur l’aspect initial de la décoration en relief. Une conception semblable des chapiteaux a incité des chercheurs renommés à leur accorder une attention particulière. Ceci est à l’origine de nombreuses études des chercheurs renommés couvrant des aires plus larges. C’est également le sujet de la partie principale de notre texte. Des modèles des chapiteaux antiques traditionnels étant trouvés en Italie, à Rome et en Italie méridionale. Nous désignons des conceptions plus tardives comme

  17. SERSO: Summer sun against winter ice; SERSO: Mit Sommer-Sonne gegen Winter-Glatteis

    Energy Technology Data Exchange (ETDEWEB)

    Eugster, W J [Polydynamics Engineering, Zuerich (Switzerland); Hess, K [Polydynamics Engineering, Bremgarten-Bern (Switzerland); Hopkirk, R J [Polydynamics Engineering, Maennedorf (Switzerland)


    Road surfaces absorb energy from the incoming solar radiation in the summer months. The SERSO project was conceived to collect this energy, store it and reuse it during the following winter period to eliminate ice formation on those same road surfaces. The acronym SERSO (Sonnenenergierueckgewinnung aus Strassenoberflaechen) means `solar energy recuperation from road surfaces`. This pilot unit having been conceived, researched an applied to a bridge on the Swiss national expressway A8 near Daerligen on the south side of the lake of Thun was officially opened on 22nd August 1994. Heat exchanger tubes carrying a water/glycol heat transfer fluid were built into the roadbed on the bridge, covering a total area of some 1`300 m{sup 2}. In summer these collect heat from the exposed carriageways, which is then transported in a closed hydraulic circuit to the neighbouring cylindrical underground rock heat storage volume. Within a diameter of 31.5 m and a depth of 65 m heat is exchanged between the heat transfer fluid and the rock via an array of 91 borehole heat exchangers. The operation of the pilot plant has been accompanied by detailed measurement campaign, whereby a total of 132 sensors are interrogated by remote datalogger. The data consist of temperature measurements at several depths and positions both in the roadbed and in the rock storage volume, of energy fluxes in the hydraulic system and of relevant meteorological data. The experiences gianed during the first two years of operation have shown that sufficient heat can indeed be collected in summer to maintain the bridge free of ice during the following winter. Moreover the energy balances derived from the measurements in the low temperature rock heat store have confirmed the predicted storage efficiency. (orig./AKF) [Deutsch] cVerkehrsflaechen heizen sich im Sommer durch Sonneneinstrahlung stark auf. Diese Sommerwaerme zu sammeln, zwischenzuspeichern und im Winter zur Verhinderung von Glatteisbildung wieder zu

  18. Drug-eluting stents with biodegradable polymer for the treatment of patients with diabetes mellitus: clinical outcome at 2 years in a large population of patients

    Directory of Open Access Journals (Sweden)

    Wiemer M


    Full Text Available Marcus Wiemer,1 Gian Battista Danzi,2 Nick West,3 Vassilios Voudris,4 René Koning,5 Stefan Hoffmann,6 Mario Lombardi,7 Josepa Mauri,8 Rade Babic,9 Fraser Witherow10On behalf of the NOBORI 2 Investigators 1Department of Cardiology, Heart and Diabetes Center North Rhine–Westphalia, Ruhr University Bochum, Bad Oeynhausen, Germany; 2Ospedale Maggiore Policlinico, Milan, Italy; 3Papworth Hospital, Cambridge, UK; 4Onassis Cardiac Surgery Center, Athens, Greece; 5Clinique Saint Hilaire, Rouen, France; 6Vivantes Netzwerk für Gesundheit GmbH, Berlin, Germany; 7Azienda Ospedaliera Villa Sofia, Palermo, Italy; 8Hospital Universitari Germans Trias i Pujol, Badalona, Spain; 9Institute for Cardiovascular Diseases Dedinje, Belgrade, Serbia; 10Dorset County Hospital, Dorchester, UK Objective: This study investigates the safety and efficacy of a third-generation drug-eluting stent (DES with biodegradable polymer in the complex patient population of diabetes mellitus (DM. Clinical trial registration: ISRCTN81649913. Background: Percutaneous coronary interventions in patients with DM are associated with a higher incidence of death, restenosis, and stent thrombosis as compared to non-diabetic patients. The use of a DES has been shown to improve outcomes in diabetic patients. Methods: Out of 3,067 patients, enrolled in 126 centers worldwide in the NOBORI 2 registry, 888 patients suffered from DM, 213 of them (14% being insulin-dependent DM (IDDM. Two years’ follow-up has been completed in this study. Results: At 1- and 2-year follow-up, 97% and 95% of the patients, respectively, were available. The reported target lesion failure (TLF rates at 1- and 2-year follow-up were 6.0% and 7.2% in the DM group, respectively, and 3.0% and 4.2% in the non-DM group, respectively (P<0.001 for both years. Inside the DM group, the TLF rates of 9.9% and 11.7% at the 1- and 2-year follow-ups, respectively, in patients with IDDM were significantly higher than the TLF rates of 4

  19. Hubble Space Telescope: The Telescope, the Observations & the Servicing Mission (United States)


    Today the HST Archives contain more than 260 000 astronomical observations. More than 13 000 astronomical objects have been observed by hundreds of different groups of scientists. Direct proof of the scientific significance of this project is the record-breaking number of papers published : over 2400 to date. Some of HST's most memorable achievements are: * the discovery of myriads of very faint galaxies in the early Universe, * unprecedented, accurate measurements of distances to the farthest galaxies, * significant improvement in the determination of the Hubble constant and thus the age of the Universe, * confirmation of the existence of blacks holes, * a far better understanding of the birth, life and death of stars, * a very detailed look at the secrets of the process by which planets are created. Europe and HST ESA's contribution to HST represents a nominal investment of 15%. ESA provided one of the two imaging instruments - the Faint Object Camera (FOC) - and the solar panels. It also has 15 scientists and computer staff working at the Space Telescope Science Institute in Baltimore (Maryland). In Europe the astronomical community receives observational assistance from the Space Telescope European Coordinating Facility (ST-ECF) located in Garching, Munich. In return for ESA's investment, European astronomers have access to approximately 15% of the observing time. In reality the actual observing time competitively allocated to European astronomers is closer to 20%. Looking back at almost ten years of operation, the head of ST-ECF, European HST Project Scientist Piero Benvenuti states: "Hubble has been of paramount importance to European astronomy, much more than the mere 20% of observing time. It has given the opportunity for European scientists to use a top class instrument that Europe alone would not be able to build and operate. In specific areas of research they have now, mainly due to HST, achieved international leadership." One of the major reasons for

  20. HUBBLE provides multiple views of how to feed a black hole (United States)


    :// or GIF and JPEG images are available via anonymous ftp to in /pubinfo/jpeg/9814a.jpg, /pubinfo/jpeg/9814.jpg, /pubinfo/gif/9814a.gif and /pubinfo/gif/9814b.gif. The Space Telescope Science Institute is operated by the Association of Universities for Research in Astronomy, Inc. (AURA) for NASA, under contract with the Goddard Space Flight Center, Greenbelt, MD. The Hubble Space Telescope is a project of international cooperation between ESA and NASA. For further information, please contact : ESA Public Relations Division Tel: +33(0) Fax: +33(0) Prof. Piero Benvenuti Head of European Coordination Facility for the HST Tel: +49.(0) Fax: +49(0)

  1. First Light for ASTROVIRTEL Project (United States)


    place in the fields of telescope and detector construction, computer hardware, data processing, archiving, and telescope operation. Nowadays astronomical telescopes can image increasingly large areas of the sky. They use more and more different instruments and are equipped with ever-larger detectors. The quantity of astronomical data collected is rising dramatically, generating a corresponding increase in potentially interesting research projects. These large collections of valuable data have led to the useful concept of "data mining", whereby large astronomical databases are exploited to support original research. However, it has become obvious that scientists need additional support to cope efficiently with the massive amounts of data available and so to exploit the true potential of the databases. The strengths of ASTROVIRTEL ASTROVIRTEL is the first virtual astronomical telescope dedicated to data mining. It is currently being established at the joint ESO/Space Telescope-European Coordinating Facility Archive in Garching (Germany). Scientists from EC member countries and associated states will be able to apply for support for a scientific project based on access to and analysis of data from the Hubble Space Telescope (HST), Very Large Telescope (VLT), New Technology Telescope (NTT), and Wide Field Imager (WFI) archives, as well as a number of other related archives, including the Infrared Space Observatory (ISO) archive. Scientists will be able to visit the archive site and collaborate with the archive specialists there. Special software tools that incorporate advanced methods for exploring the enormous quantities of information available will be developed. Statements The project co-ordinator, Piero Benvenuti , Head of ST-ECF, elaborates on the advantages of ASTROVIRTEL: "The observations by the ESA/NASA Hubble Space Telescope and, more recently, by the ESO Very Large Telescope, have already been made available on-line to the astronomical community, once the

  2. The Trieste Lecture of John Stewart Bell

    International Nuclear Information System (INIS)

    Bassi, Angelo; Ghirardi, GianCarlo


    Delivered at Trieste on the occasion of the 25th Anniversary of the International Centre for Theoretical Physics, 2 November 1989. The video of this lecture is available here. Please see the PDF for the transcript of the lecture. General remarks by Angelo Bassi and GianCarlo Ghirardi During the autumn of 1989 the International Centre for Theoretical Physics, Trieste, celebrated the 25th anniversary of its creation. Among the many prestigious speakers, who delivered extremely interesting lectures on that occasion, was the late John Stewart Bell. All lectures have been recorded on tape. We succeeded in getting a copy of John's lecture. In the lecture, many of the arguments that John had lucidly stressed in his writings appear once more, but there are also extremely interesting new remarks which, to our knowledge, have not been presented elsewhere. In particular he decided, as pointed out by the very choice of the title of his lecture, to call attention to the fact that the theory presents two types of difficulties, which Dirac classified as first and second class. The former are those connected with the so-called macro-objectification problem, the latter with the divergences characterizing relativistic quantum field theories. Bell describes the precise position of Dirac on these problems and he stresses appropriately how, contrary to Dirac's hopes, the steps which have led to a partial overcoming of the second class difficulties have not helped in any way whatsoever to overcome those of the first class. He then proceeds to analyse the origin and development of the Dynamical Reduction Program and draws attention to the problems that still affect it, in particular that of a consistent relativistic generalization. When the two meetings Are there quantum jumps? and On the present status of Quantum Mechanics were organized in Trieste and Losinj (Croatia), on 5-10 September 2005, it occurred to us that this lecture, which has never been published, might represent an

  3. Something going on in Milan: a review of the 4th International PhD Student Cancer Conference. (United States)

    Segré, C


    with other prestigious research centres and to create connections for future post docs or job experiences. And last but not least, it is a golden chance for penniless PhD students to spend a couple of extra days visiting a foreign country (this motivation will of course never be voiced to supervisors).The network of participating institutes has a three-nation core, made up of the Netherlands Cancer Institute, the Italian European School of Molecular Medicine (SEMM) and five UK Cancer Research Institutes (The London Research Institute, The Cambridge Research Institute, The Beatson Institute for Cancer Research in Glasgow, The Patterson Institute for Cancer Research in Manchester and the MRC Gray Institute for Radiation Oncology and Biology in Oxford).The conference is hosted and organised every year by one of the core institutes; the first was in Cambridge in 2007, Amsterdam in 2008 and London in 2009, this year was the turn of Milan.In addition to the core institutes, PhD students from several other high-profile institutes are invited to attend the conference. This year participants applied from the Spanish National Cancer Centre (CNIO, Madrid), the German Cancer Research Centre (DKFZ, Heidelberg), the European Molecular Biology Labs (EMBL, Heidelberg) and the San Raffaele Institute (HSR, Milan). Moreover four 'special guests' from the National Centre for Biological Sciences of Bangalore (India) attended the conference in Milan. This represents a first step in widening the horizons beyond Europe into a global worldwide network of talented PhD students in life sciences.The conference spread over two and a half days (Wednesday 19th to Friday 21st May) and touched on a broad spectrum of topics: from basic biology to development, from cancer therapies to modelling and top-down new generation global approaches. The final selection of presentations has been a tough task for us organisers (Chiara Segré, Federica Castellucci, Francesca Milanesi, Gianluca Varetti and Gian

  4. The Project Serapis: High Resolution Seismic Imagingof The Campi Flegrei Caldera Structure (United States)

    Zollo, A.; Virieux, J.; Capuano, P.; Chiarabba, C.; de Franco, R.; Makris, J.; Michelini, A.; Musacchio, G.; Serapis Group

    , Iannaccone Giovanni, La Rocca Mario, Saccorotti Gilberto, Cattaneo Marco, De Mar- tin Martina , Colasanti Gianfranco, Moretti Milena, Marcello Silvestri, Edoardo Gian- domenico, Raffaele Stefano, Graziano Boniolo, Maria Rosaria Tondi, Maistrello Mar- iano, Gomez Antonio, Piccareda Carlo, Paolo Di Bartolomeo, Marco Romanelli, So- phie Peyrat, Christophe Larroque, Claude Pambrun, Tony Monfret, Stephane Gaffet, Mark Noble, Sylvain Nguyen 2

  5. 1992 WAMET/EUROMET Joint Expedition to Search for Meteorites in the Nullarbor Region, Western Australia (United States)

    Bevan, A.


    The Nullarbor Region is a limestone desert in the south of Australia. It forms part of the larger Eucla Basin, which straddles the border between South Australia and Western Australia. The portion of the Eucla Basin lying in Westem Australia covers an area of about 104,000 km^2 (Bevan and Binns, 1989) and meteorites have been recovered from this region since 1971, new material being deposited at the Western Australia Museum. Between 21/3/92 and 6/4/92 a joint expedition between the Western Australia Museum and EUROMET recovered approximately 440 specimens of meteorites (total mass 13206 g) and 297 tektites. The expedition, whose members were Claude Perron (Paris), Christian Koeberl (Vienna), Georg Delisle (BGR Hannover), Gian- Paolo Sighinolfi (Modena), and Andrew Morse (OU) for Euromet, together with Wayne Smith (Australian Army) and Tom Smith (Perth Astronomical Observatory), was led by Dr Alex Bevan of the Western Australia Museum. Searching was carried out on foot with the participants spread out in a line with a 10-m spacing, walking along a compass bearing for approximately 10 km and back each day. Eight collecting regions were used, with a stop of about 2 days at each camp. Half of the searching was done near known strewn fields in order that the team become practised. Thus the expedition collected material at the following known sites. Camel Donga, Eucrite: The initial recovery was made in 1984 (Cleverly et al., 1986). The strewn field is about 8 km by 2-3 km at coordinates 30 degrees 19'S, 126 degrees 37'E. This expedition recovered 65 stones weighing a total of 2456 g, plus one stone of 4.8 g that was clearly chondritic in hand specimen. Mulga (north), H6: The initial recovery was made in 1964 (McCall, 1968). The strewn field is 8 km by 2 km at coordinates 30 degrees 11'S, 126 degrees 22'E and on this expedition 5 stones were recovered with a weight of 548 g. Also 110 stones (total mass 1535 g) that are certainly not H6 were found within a 100-m radius of

  6. EDITORIAL: Lectures from the European RTN Winter School on Strings, Supergravity and Gauge Theories, CERN, 21 25 January 2008 (United States)

    Derendinger, J.-P.; Orlando, D.; Uranga, A.


    been limited by the difficulties of quantizing the worldsheet theory in the presence of RR backgrounds. There is increasing hope that these difficulties can be overcome, using the pure spinor formulation of string theory. The lectures by Yaron Oz overview the present status of this proposal. The gauge/gravity correspondence is already leading to important insights into questions of quantum gravity, like the entropy of black holes and its interpretation in terms of microstates. These questions can be addressed in string theory, for certain classes of supersymmetric black holes. The lectures by Vijay Balasubramanian, Jan de Boer, Sheer El-Showk and Ilies Messamah review recent progress in this direction. Throughout the years, formal developments in string theory have systematically led to improved understanding on how it may relate to nature. In this respect, the lectures by Henning Samtleben describe how the formal developments on gauged supergravities can be used to describe compactification vacua in string theory, and their implications for moduli stabilization and supersymmetry breaking. Indeed, softly broken supersymmetry is one of the leading proposals to describe particle physics at the TeV energy range, as described in the lectures by Gian Giudice (not covered in this issue). This connection with TeV scale physics is most appropriate and timely, given that this energy range will shortly become experimentally accessible in the LHC at CERN. The conference was financially supported by the European Commission under contract MRTN-CT-2004-005104 and by CERN. It was jointly organized by the Physics Institute of the University of Neuchâtel and the Theory Unit of the Physics Division of CERN. It is a great pleasure for us to warmly thank the Theory Unit of CERN for its very kind hospitality and for the high quality of the assistance and the infrastructure that it has provided. We also acknowledge helpful administrative assistance from the Physics Institute of the

  7. The Trieste Lecture of John Stewart Bell

    Energy Technology Data Exchange (ETDEWEB)

    Bassi, Angelo; Ghirardi, GianCarlo


    Delivered at Trieste on the occasion of the 25th Anniversary of the International Centre for Theoretical Physics, 2 November 1989. The video of this lecture is available here. Please see the PDF for the transcript of the lecture. General remarks by Angelo Bassi and GianCarlo Ghirardi During the autumn of 1989 the International Centre for Theoretical Physics, Trieste, celebrated the 25th anniversary of its creation. Among the many prestigious speakers, who delivered extremely interesting lectures on that occasion, was the late John Stewart Bell. All lectures have been recorded on tape. We succeeded in getting a copy of John's lecture. In the lecture, many of the arguments that John had lucidly stressed in his writings appear once more, but there are also extremely interesting new remarks which, to our knowledge, have not been presented elsewhere. In particular he decided, as pointed out by the very choice of the title of his lecture, to call attention to the fact that the theory presents two types of difficulties, which Dirac classified as first and second class. The former are those connected with the so-called macro-objectification problem, the latter with the divergences characterizing relativistic quantum field theories. Bell describes the precise position of Dirac on these problems and he stresses appropriately how, contrary to Dirac's hopes, the steps which have led to a partial overcoming of the second class difficulties have not helped in any way whatsoever to overcome those of the first class. He then proceeds to analyse the origin and development of the Dynamical Reduction Program and draws attention to the problems that still affect it, in particular that of a consistent relativistic generalization. When the two meetings Are there quantum jumps? and On the present status of Quantum Mechanics were organized in Trieste and Losinj (Croatia), on 5-10 September 2005, it occurred to us that this lecture, which has never been published, might represent

  8. Chandra and the VLT Jointly Investigate the Cosmic X-Ray Background (United States)


    representative of this elusive class of objects (referred to as ' Type II Quasars ') which are believed to account for approximately 90% of the black-hole-powered quasars in the distant Universe. The 'sum' of the identified Chandra X-ray sources in the CDFS was found to match both the intensity and the spectral properties of the observed X-ray background. This important result is a significant step forward towards the definitive resolution of this long-standing cosmological problem. Naturally, ESO astronomer Piero Rosati and his colleagues are thrilled: " It is clearly the combination of the new and detailed Chandra X-ray observations and the enormous light-gathering power of the VLT that has been instrumental to this success. " However, he says, " the identification of the remaining Chandra X-ray sources will be the next challenge for the VLT since they are extremely faint. This is because they are either heavily obscured by dust or because they are extremely distant ". More Information This Press Release is issued simultaneously with a NASA Press Release (see also the Harvard site ). Some of the first results are described in a research paper ("First Results from the X-ray and Optical Survey of the Chandra Deep Field South" available on the web at astro-ph/0007240. More information about science results from the Chandra X-Ray Observatory may be found at: The optical survey of CDFS at ESO with the Wide-Field Imager is described in connection with PR Photos 46a-b/99 ('100,000 galaxies at a glance'). An image of the Chandra Deep Field South is available at the ESO website on the EIS Image Gallery webpage. . Notes [1]: The Chandra Team is lead by Riccardo Giacconi (Association of Universities Inc. [AUI], Washington, USA) and includes: Piero Rosati , Jacqueline Bergeron , Roberto Gilmozzi , Vincenzo Mainieri , Peter Shaver (European Southern Observatory [ESO]), Paolo Tozzi , Mario Nonino , Stefano Borgani (Osservatorio Astronomico, Trieste, Italy), Guenther

  9. Images From Hubbles's ACS Tell A Tale Of Two Record-Breaking Galaxy Clusters (United States)


    accurate tracer of its total mass. A paper by Piero Rosati of the European Southern Observatory (ESO) and colleagues that presents the X-ray observations of RDCS 1252 will be published in January 2004 in the Astronomical Journal. "Chandra's sharp vision resolved the shape of the hot gas halo and showed that RDCS 1252 is very mature for its age," said Rosati, who discovered the cluster with the ROSAT X-ray telescope. RDCS 1252 may contain many thousands of galaxies. Most of these galaxies, however, are too faint to detect. But the powerful "eyes" of the ACS pinpointed several hundred of them. Observations using ESO's Very Large Telescope (VLT) provided a precise measurement of the distance to the cluster. The ACS enabled the researchers to accurately determine the shapes and colors of the 100 galaxies, providing information on the ages of the stars residing in them. The ACS team estimated that most of the stars in the cluster were already formed when the universe was about 2 billion years old. X-ray observations, furthermore, showed that 5 billion years after the big bang the surrounding hot gas had been enriched with heavy elements from these stars and had been swept away from the galaxies. If most of the galaxies in RDCS 1252 have reached maturity and are settling into a quiet adulthood, the forming galaxies in the distant proto-cluster are in their energetic, unruly youth. The proto-cluster TN J1338 contains a massive embryonic galaxy surrounded by smaller developing galaxies, which look like dots in the Hubble image. The dominant galaxy is producing spectacular radio-emitting jets, fueled by a supermassive black hole deep within the galaxy's nucleus. Interaction between these jets and the gas can stimulate a torrent of star birth. The energetic radio galaxy's discovery by radio telescopes prompted astronomers to hunt for the smaller galaxies that make up the bulk of the cluster. "Massive clusters are the cities of the universe, and the radio galaxies within them are the

  10. Press Meeting 20 January 2003: First Light for Europe's Virtual Observatory (United States)


    Imagine you are an astronomer with instant, fingertip access to all existing observations of a given object and the opportunity to sift through them at will. In just a few moments, you can have information on all kinds about objects out of catalogues all over the world, including observations taken at different times. Over the next two years this scenario will become reality as Europe's Astrophysical Virtual Observatory (AVO) develops. Established only a year ago (cf. ESO PR 26/01), the AVO already offers astronomers a unique, prototype research tool that will lead the way to many outstanding new discoveries. Journalists are invited to a live demonstration of the capabilities of this exciting new initiative in astronomy. The demonstration will take place at the Jodrell Bank Observatory in Manchester, in the United Kingdom, on 20 January 2003, starting at 11:00. Sophisticated AVO tools will help scientists find the most distant supernovae - objects that reveal the cosmological makeup of our Universe. The tools are also helping astronomers measure the rate of birth of stars in extremely red and distant galaxies. Journalists will also have the opportunity to discuss the project with leading astronomers from across Europe. The new AVO website has been launched today, explaining the progress being made in this European Commission-funded project: URL: To register your intention to attend the AVO First Light Demonstration, please provide your name and affiliation by January 13, 2003, to: Ian Morison, Jodrell Bank Observatory (full contact details below). Information on getting to the event is included on the webpage above. Programme for the AVO First Light Demonstration 11:00 Welcome, Phil Diamond (University of Manchester/Jodrell Bank Observatory) 11:05 Short introduction to Virtual Observatories, Piero Benvenuti (ESA/ST-ECF) 11:15 Q&A 11:20 Short introduction to the Astrophysical Virtual Observatory, Peter Quinn (ESO) 11:30 Q&A 11:35 Screening of

  11. XXXI LIAC Meeting on Vascular Research - Proceedings

    Directory of Open Access Journals (Sweden)

    L. Monteiro Rodrigues et al.



  12. Short-Lived Isotopes Used as Tracers in Industry (with Special Reference to Swedish Industry); Emploi de Radioindicateurs de Courte Periode a l'Echelle Industrielie dans les Usines Suedoises; ПРИМЕНЕНИЕ КОРОТКОЖИВУЩИХ ИЗОТОПОВ В ПРОМЫШЛЕННОСТИ В КАЧЕСТВЕ МЕЧЕНЫХ АТОМОВ; Isotopos de Periodo Corto Utilizados Como Indicadores en la Industria Sueca

    Energy Technology Data Exchange (ETDEWEB)

    Erwall, L. G.; Forsberg, H. G.; Ljunggren, K. [Isotoptekniska Laboratoriet, Stockholm (Sweden)


    une certitude absolue des bains d'acier d'experimentation et certains autres produits de l'industrie siderurgique determination de l'efficacite des melangeurs dans l'industrie du beton; etude de l'ecoulement dans les fosses receptrices d'eaux usees en vue de decouvrir le meilleur point d'evacuation; detection et localisation des fuites. Dans beaucoup de ces etudes, l'utilisation d'indicateuts de courte periode a ete indispensable pour reduire au minimum la contamination du produit final. Dans la plupart des cas, il s'agit d'un marquage purement physique a l'aide de divers indicateurs possibles. On peut ainsi choisir un indicateur ayant une periode appropriee et les caracteristiques de rayonnement voulues. Si le radionucleide utilise presente une grande section efficace pour l'activation par les neutrons - ce qui est le cas des nucleides enumeres plus haut - un reacteur de recherche aura un flux de neutrons suffisant pour produire des activites de l'ordre de plusieurs curies, a moins que l'on ait besoin d'une forte activite specifique. En Suede, un institut industriel mixte, le Laboratoire des methodes isotopiques, a ete cree en 1960 et charge de faire des travaux de recherche et de mise au point, et d'aider les entreprises industrielles en leur donnant lea conseils, le personnel et les appareils dont elles ont besoin pour appliquer les methodes utilisant les radioisotopes. (author) [Spanish] Rapidamente se va reconociendo que los metodos basados en el empleo de indicadores radiactivos son muy valiosos en la investigacion y el control industriales. Se han utilizado ya con gian exito para localizar defectos, estudiar las caracteristicas de instalaciones industriales y como ayuda para disenar dichas instalaciones. La presente memoria cita ejemplos tipicos de las aplicaciones de los indicadores de periodo corto que se pueden obtener con flujos neutronicos medios, por ejemplo, {sup 24}Na, {sup 38}Cl, {sup 42}K, {sup 56}Mn, {sup 82}Br, {sup 140}La y {sup 198}Au: Estudio del

  13. 16th National Congress of the South African Society of Psychiatrists (SASOP

    Directory of Open Access Journals (Sweden)

    Christer Allgulander


    of start Sean Kaliski 21. Psychiatric disorders abd psychosocial correlates of high HIV risk sexual behaviour in war-effected Eatern Uganda E Kinyada, H A Weiss, M Mungherera, P Onyango Mangen, E Ngabirano, R Kajungu, J Kagugube, W Muhwezi, J Muron, V Patel 22. One year of Forensic Psychiatric assessment in the Northern Cape: A comparison with an established assessment service in the Eastern Cape N K Kirimi, C Visser 23. Mental Health service user priorities for service delivery in South Africa Sharon Kleintjes, Crick Lund, Leslie Swartz, Alan Flisher and MHaPP Research Programme Consortium 24. The nature and extent of over-the-counter and prescription drug abuse in cape town Liezl Kramer 25. Physical health issues in long-term psychiatric inpatients: An audit of nursing statistics and clinical files at Weskoppies Hospital Christa Kruger 26. Suicide risk in Schizophrenia - 20 Years later, a cohort study Gian Lippi, Ean Smit, Joyce Jordaan, Louw Roos 27.Developing mental health information systems in South Africa: Lessons from pilot projects in Northern Cape and KwaZulu-Natal Crick Lund, S Skeen, N Mapena, C Isaacs, T Mirozev and the Mental Health and Poverty Research Programme Consortium Institution 28. Mental health aspects of South African emigration Maria Marchetti-Mercer 29. What services SADAG can offer your patients Elizabeth Matare 30. Culture and language in psychiatry Dan Mkize 31. Latest psychotic episode Povl Munk-Jorgensen 32. The Forensic profile of female offenders Mo Nagdee, Helmut Fletcher 33. The intra-personal emotional impact of practising psychiatry Margaret Nair 34. Highly sensitive persons (HSPs and implications for treatment Margaret Nair 35. Task shifting in mental health - The Kenyan experience David M Ndetei 36. Bridging the gap between traditional healers and mental health in todya's modern psychiatry David M Ndetei 37. Integrating to achieve modern psychiatry David M Ndetei 38. Non-medical prescribing: Outcomes from a pharmacist-led post

  14. PREFACE: Fourth Meeting on Constrained Dynamics and Quantum Gravity (United States)

    Cadoni, Mariano; Cavaglia, Marco; Nelson, Jeanette E.


    ) Georgi Dvali (NYU, USA) Sergio Ferrara (CERN) Gian Francesco Giudice (CERN) Roman Jackiw (MIT, USA) Edward W. Kolb (Fermilab, USA) Luca Lusanna (INFN Firenze, Italy) Roy Maartens (Univ. Portsmouth, UK) Hermann Nicolai (AEI, Potsdam, Germany) Tullio Regge (Politecnico di Torino, Italy) Augusto Sagnotti (Univ. Roma Tor Vergata, Italy) Kellogg S. Stelle (Imperial College London, UK) Ruth Williams (DAMTP, Cambridge, UK) SPONSORS Istituto Nazionale di Fisica Nucleare Università di Cagliari Università di Torino University of Mississippi Università di Pisa Regione autonoma della Sardegna Tiscali LIST OF PARTICIPANTS Eun-Joo Ahn (University of Chicago, USA) David Alba (Università di Firenze, Italy) Stanislav Alexeyev (Lomonosov Moscow State U., Russia) Damiano Anselmi (Università di Pisa, Italy) Ignatios Antoniadis (CERN, Geneva, Switzerland) Maria Da Conceicao Bento (Instituto Superior Técnico, Lisboa, Portugal) Orfeu Bertolami (Instituto Superior Técnico, Lisboa, Portugal) Massimo Bianchi (Università di Roma Tor Vergata, Italy) Mariam Bouhmadi-Lopez (University of Portsmouth, UK) Raphael Bousso (University of California at Berkeley, USA) Mariano Cadoni (Università di Cagliari, Italy) Steven Carlip (University of California at Davis, USA) Roberto Casadio (Università di Bologna, Italy) Marco Cavaglià (University of Mississippi, USA) Demian Cho (Raman Research Institute, Bangalore, India) Theodosios Christodoulakis (University of Athens, Greece) Chryssomalis Chryssomalakos (Inst. de Ciencias Nucleares - UNAM, Mexico) Diego Julio Cirilo-Lombardo (JINR, Dubna, Russia) Denis Comelli INFN, Sezione di Ferrara, Italy ) Ruben Cordero-Elizalde (Instituto Politecnico Nacional, Mexico) Lorenzo Cornalba (Università di Roma Tor Vergata, Italy) Branislav Cvetkovic (Institute of Physics, Belgrade, Serbia ) Maro Cvitan (University of Zagreb, Croatia) Alessandro D'Adda (Università di Torino, Italy) Claudio Dappiaggi (Università di Pavia, Italy) Roberto De Leo (Università di

  15. Deepest Wide-Field Colour Image in the Southern Sky (United States)


    LA SILLA CAMERA OBSERVES CHANDRA DEEP FIELD SOUTH ESO PR Photo 02a/03 ESO PR Photo 02a/03 [Preview - JPEG: 400 x 437 pix - 95k] [Normal - JPEG: 800 x 873 pix - 904k] [HiRes - JPEG: 4000 x 4366 pix - 23.1M] Caption : PR Photo 02a/03 shows a three-colour composite image of the Chandra Deep Field South (CDF-S) , obtained with the Wide Field Imager (WFI) camera on the 2.2-m MPG/ESO telescope at the ESO La Silla Observatory (Chile). It was produced by the combination of about 450 images with a total exposure time of nearly 50 hours. The field measures 36 x 34 arcmin 2 ; North is up and East is left. Technical information is available below. The combined efforts of three European teams of astronomers, targeting the same sky field in the southern constellation Fornax (The Oven) have enabled them to construct a very deep, true-colour image - opening an exceptionally clear view towards the distant universe . The image ( PR Photo 02a/03 ) covers an area somewhat larger than the full moon. It displays more than 100,000 galaxies, several thousand stars and hundreds of quasars. It is based on images with a total exposure time of nearly 50 hours, collected under good observing conditions with the Wide Field Imager (WFI) on the MPG/ESO 2.2m telescope at the ESO La Silla Observatory (Chile) - many of them extracted from the ESO Science Data Archive . The position of this southern sky field was chosen by Riccardo Giacconi (Nobel Laureate in Physics 2002) at a time when he was Director General of ESO, together with Piero Rosati (ESO). It was selected as a sky region towards which the NASA Chandra X-ray satellite observatory , launched in July 1999, would be pointed while carrying out a very long exposure (lasting a total of 1 million seconds, or 278 hours) in order to detect the faintest possible X-ray sources. The field is now known as the Chandra Deep Field South (CDF-S) . The new WFI photo of CDF-S does not reach quite as deep as the available images of the "Hubble Deep Fields

  16. Exploring the Digital Universe with Europe's Astrophysical Virtual Observatory (United States)


    organisations are the European Space Agency (ESA) , the United Kingdom's ASTROGRID consortium, the CNRS-supported Centre de Données Astronomiques de Strasbourg (CDS) at the University Louis Pasteur in Strasbourg (France), the CNRS-supported TERAPIX astronomical data centre at the Institut d'Astrophysique in Paris and the Jodrell Bank Observatory of the Victoria University of Manchester (UK). Note [1]: This is a joint Press Release issued by the European Southern Observatory (ESO), the Hubble European Space Agency Information Centre, ASTROGRID, CDS, TERAPIX/CNRS and the University of Manchester. A 13 minute background video (broadcast PAL) is available from ESO PR and the Hubble European Space Agency Information Centre (addresses below). This will also be transmitted via satellite Wednesday 12 December 2001 from 12:00 to 12:15 CET on "ESA TV Service", cf. An international conference, "Toward an International Virtual Observatory" will take place at ESO (Garching, Germany) on June 10 - 14, 2002. Contacts AVO Contacts Peter Quinn European Southern Observatory Garching, Germany Tel.: +4989-3200-6509 email: Piero Benvenuti Space Telescope-European Coordinating Facility Garching, Germany Tel.: +49-89-3200-6290 email: Andy Lawrence (on behalf of The ASTROGRID Consortium) Institute for Astronomy University of Edinburgh United Kingdom Tel.: +44-131-668-8346/56 email: Francoise Genova Centre de Données Astronomiques de Strasbourg (CDS) France Tel.: +33-390-24-24-76 email: Yannick Mellier CNRS, Delegation Paris A (CNRSDR01-Terapix)/IAP/INSU France Tel.: +33-1-44-32-81-40 email: Phil Diamond University of Manchester/Jodrell Bank Observatory United Kingdom Tel.: +44-147-757-2625 email: PR Contacts Richard West European Southern Observatory Garching, Germany Tel.: +49-89-3200-6276 email: Lars Lindberg Christensen Hubble European Space Agency

  17. List of Participants (United States)


    MoralIstituto Nazionale di Fisica Nucleare, Università di Torino Valentina Giangreco Marotta PulettiUppsala University Valeria L GiliQueen Mary, University of London Luciano GirardelloUniversità di Milano-Bicocca Gian GiudiceCERN, Geneva Kevin Goldstein Institute for Theoretical Physics, Utrecht University Joaquim Gomis Universitat de Barcelona Pietro Antonio GrassiUniversità del Piemonte Orientale, Alessandria Viviane GraßLudwig-Maximilians-Universität, München Gianluca Grignani Università di Perugia Luca Griguolo Università di Parma Johannes GrosseJagiellonian University, Krakow Umut Gursoy École Polytechnique, Palaiseau Norberto Gutierrez RodriguezUniversity of Oviedo Babak HaghighatPhysikalisches Institut, Universität Bonn Troels Harmark Niels Bohr Institute, København Robert HaslhoferEidgenössische Technische Hochschule (ETH), Zürich Tae-Won HaPhysikalisches Institut, Universität Bonn Alexander HauptImperial College London and Max-Planck-Institut für Gravitationsphysik (AEI), Potsdam Marc HenneauxUniversité Libre de Bruxelles Johannes HennLAPTH, Annecy-le-Vieux Shinji HiranoNiels Bohr Institute, København Stefan HoheneggerEidgenössische Technische Hochschule (ETH), Zürich Jan HomannLudwig-Maximilians-Universität, München Gabriele Honecker CERN, Geneva Joost HoogeveenInstituut voor Theoretische Fysica, Universiteit van Amsterdam Mechthild HuebscherUniversidad Autónoma de Madrid Chris HullImperial College London Carmen-Liliana IonescuUniversity of Craiova Ella JasminUniversité Libre de Bruxelles Konstantin KanishchevInstitute of Theoretical Physics, University of Warsaw Stefanos Katmadas Utrecht University Alexandros KehagiasNational Technical University of Athens Christoph Keller Eidgenössische Technische Hochschule (ETH), Zürich Patrick Kerner Max-Planck-Institut für Physik, München Rebiai KhaledLaboratoire de Physique Mathématique et Physique Subatomique, Université Mentouri, Constantine Elias Kiritsis Centre de Physique Théorique,