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Sample records for gestantes con preeclampsia

  1. Eficacia del parto por cesárea comparado con parto vaginal en gestantes con preeclampsia severa según complicaciones maternas y neonatales

    OpenAIRE

    Salazar Cruzado, Orlando Rodolfo

    2010-01-01

    An ex post facto study was done at Belen Hospital Obstetrics Service between January and December 2009 to compare the effectiveness of cesarean and vaginal delivery in pregnant women with severe preeclampsia according to maternal and neonatal complications. The study was made with 218 pregnant women with severe preeclampsia from which 167 had cesarean deliveries and 51 vaginal ones. Both groups were compared according to their demographic and obstetric characteristics, having more incidences ...

  2. Niveles séricos del factor neurotrófico derivado del cerebro durante la gestación normal y la preeclampsia

    Directory of Open Access Journals (Sweden)

    Liza Lorena Colorado Barbosa

    2016-04-01

    Conclusiones. El BDNF puede participar en la regulación del peso corporal y el metabolismo de la glucosa en mujeres gestantes, pero el nivel de BDNF, solo o en conjunto con otras variables, no puede explicar la preeclampsia.

  3. Polimorfismo del gen de la catecol-O-metiltransferasa (COMT) en gestantes con restricción del crecimiento intrauterino (RCIU)

    OpenAIRE

    Pacheco, José; Huerta, Doris; Acosta, Oscar; Cabrera, Santiago

    2013-01-01

    Objetivos: Establecer la asociación entre el polimorfismo Vall58Met catecol-O-metiltransferasa (COMT) y la RCIU. Diseño: Estudio relacional, observacional, tipo caso-control. Institución: Facultad de Medicina, UNMSM. Participantes: Gestantes sin y con RCIU. Intervenciones: Se obtuvo 81 muestras de sangre para genotipaje del gen COMT; 55 (67,9%) correspondieron a gestantes sin RCIU (controles) y 26 (32,1%) a madres de hijos con RCIU. Las gestantes firmaron consentimiento informado. Principales...

  4. Salud familiar en familias con adolescente gestante Saúde familiar em famílias com adolescentes gestantes Family health in families with pregnant adolescents

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    Martha cecilia Veloza Morales

    2012-01-01

    Full Text Available La investigación se basó en la teoría de organización sistémica de Marie Louse Friedemann; el objetivo fue describir el grado de salud familiar de familias con adolescente gestante. Estudio Descriptivo transversal comparativo, con abordaje cuantitativo donde se evaluó el grado de salud familiar a 100 familias atendidas en dos instituciones prestadoras de Salud (IPS en Bogotá, Colombia; se organizaron en dos grupos: la mitad de las familias con adolescentes gestantes que presentaron morbilidad en el tercer trimestre del embarazo y la otra mitad que no presentaron morbilidad; para la recolección de la información se utilizó el instrumento ISF GES 19 diseñado, implementado y probado por la doctora Pilar Amaya de Peña. Se obtuvo una visión global acerca de la salud familiar y se comparó el grado de salud familiar de acuerdo con las características halladas en cada uno de los grupos. Se concluye que las familias no sienten o no perciben el riesgo de sufrir o no una patología durante el embarazo, y por tanto, no afecta su grado de salud familiar el cual consideran saludable y satisfecho. Se invita a crear estrategias que conlleven a disminuir los riesgos de salud a que se expone la familia y la madre adolescente.Apesquisa foi baseada na teoria da organização sistémica de Marie Louse Friedemann; o objeto foi descrever o grau de saúde familiar das famílias com adolescentes gestantes. Estu-do descritivo transversal comparativo, com abordagem quan-titativa onde foi avaliado o grau de saúde familiar de 100 famí-lias atendidas em duas instituições fornecedoras de serviços de saúde (IPS em Bogotá, Colômbia. As 100 famílias foram organizadas em dois grupos: a metade das famílias com adolescentes gestantes que apresentaram morbidez no terceiro trimestre de gravidez e a outra metade conformada por aquelas famílias com adolescentes gestantes que não apresentaram morbidez; para a compilação da informação, utilizou-se o

  5. Preeclampsia

    Science.gov (United States)

    ... preeclampsia makes a woman a higher risk for future problems such as: Heart disease Diabetes Kidney disease ... medical problems in pregnancy. In: Goldman L, Schafer AI, eds. Goldman's Cecil Medicine . 25th ed. Philadelphia, PA: ...

  6. FORMULACIÓN DE UNA BEBIDA LÁCTEA CON SABOR A AREQUIPE ENRIQUECIDA CON HIERRO Y ÁCIDO FÓLICO, DIRIGIDA A MUJERES GESTANTES

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    Jhon Jairo Bejarano Roncancio

    2011-03-01

    Full Text Available Antecedentes. Colombia se encuentra dentro de los países con prevalencia moderada de anemia en mujeres gestantes (20-40%; está comprobado que los niveles séricos de folato y hierro en la madre son factores bioquímicos relevantes para la formación del bebé. Dichas aseveraciones, justifican la formulación de un producto alimenticio enriquecido con hierro y ácido fólico,  específico para mujeres gestantes y que contribuya a mejorar sus condiciones nutricionales. Objetivo. Desarrollar una bebida láctea enriquecida con hierro y ácido fólico, endulzada y con sabor a arequipe, organolépticamente aceptable. Materiales y métodos. Para su desarrollo, se cumplieron dos etapas básicas: formulación del patrón y formulación del producto. El enriquecimiento del producto inicial  se hizo con hierro y ácido fólico y luego se determinó  la aceptación organoléptica final. Resultados. La formulación de la bebida láctea Mamá vitae sabor a arequipe, tuvo 86% de aceptación, e incluyó 10 mg de hierro aminoquelado y 230 µg de pteroilmonoglutamato por porción de 200 mL de leche; aportó el 17% de las recomendaciones de hierro y el 33% del ácido fólico para una mujer en gestación. Conclusión. Las características del producto favorecen unas mejores condiciones nutricionales a la gestante y a las mujeres fértiles que quieren planificar una gestación viable. Este tipo de productos son epidemiológicamente necesarios para poblaciones vulnerables como las mujeres gestantes y lactantes.

  7. Legrado uterino o nifedipina durante el posparto en pacientes con preeclampsia severa

    OpenAIRE

    Santos-Bolívar, Joel; Guerra-Velásquez, Mery; Reyna-Villasmil, Eduardo; Mejia-Montilla, Jorly; Reyna-Villasmil, Nadia

    2011-01-01

    Objetivo: Comparar la eficacia del legrado uterino o la nifedipina durante el posparto en pacientes con preeclampsia severa. Ambiente: Maternidad “Dr. Nerio Belloso”, Hospital Central “Dr. Urquinaona”, Maracaibo. Estado Zulia. Métodos: Se realizó una investigación en 60 pacientes con diagnóstico de preeclampsia severa que fueron divididas de la siguiente manera: grupo A (n = 30) que fueron sometidas a legrado uterino inmediatamente después del parto y grupo B (n = 30) que recibieron nifedipin...

  8. Cribado de preeclampsia con estudio doppler de las arterias uterinas

    OpenAIRE

    Figueras Falcón, Tatiana

    2016-01-01

    Programa de doctorado: Patología quirúrgica, Reproducción humana y factores psicológicos y el proceso de enfermar. La fecha de publicación es la fecha de lectura. [ES]La Preeclampsia (PE) es una de las principales causas de morbimortalidad maternofetal. Es un síndrome en el que existe una disfunción endotelial multisistémica. Varias teorías pretenden explicar el porqué de la PE para establecer factores de riesgo que puedan predisponer a su aparició...

  9. Nutrición parenteral total en una paciente gestante con pancreatitis aguda e hipertrigliceridemia por déficit de lipoproteín lipasa

    OpenAIRE

    Contreras-Bolívar, Victoria; González-Molero, Inmaculada; Valdivieso, Pedro; Olveira, Gabriel

    2015-01-01

    Presentamos un caso de pancreatitis aguda severa inducida por hipertrigliceridemia secundaria a déficit de lipoproteín lipasa (LPL) en una paciente gestante con diabetes gestacional, manejada inicialmente con dieta, siendo necesario posteriormente llevar a cabo medidas de soporte nutricional artificial: nutrición parenteral total. El déficit de LPL causa hipertrigliceridemia severa y, frecuentemente, pancreatitis aguda de repetición, situación de difícil manejo y de importante gravedad durant...

  10. Obesidad pregestacional como factor de riesgo asociado a preeclampsia

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    Zoila Moreno

    2003-06-01

    Full Text Available Objetivo: Evaluar la obesidad como factor de riesgo de preeclampsia. Diseño: Estudio caso control realizado en el Hospital Dos de Mayo, Lima, Perú. Material y Métodos: Después de excluir 35 pacientes, se comparó 107 mujeres preeclámpticas con 107 gestantes normotensas, pareadas para edad gestacional (±1 semana. Se correlacionó peso pregestacional con la presencia de preeclampsia usando chi-cuadrado; se empleó t de student para comparar promedios y se controló variables confusoras usando la regresión logística. Resultados: La preeclampsia estuvo asociada con una edad de 35 años o más (OR 3,0; IC 95% 1,2 a 7,9, historia de preeclampsia en el embarazo previo (OR 5,4; IC 95% 1,6 a 17,9 y obesidad (OR 6,5; 6,2 a 2,8, considerada como el tercil más alto de los parámetros índice de masa corporal (IMC, pliegue tricipital y circunferencia braquial media en el grupo control. Existió significativa tendencia linear de riesgo de preeclampsia con estos parámetros (p< 0,001. Conclusiones: Las mujeres obesas deben ser cuidadosamente controladas, para reducir la incidencia de preeclampsia y sus complicaciones.

  11. Prevalencia de la infección por virus de Epstein Barr (VEB en mujeres gestantes y con aborto, durante las primeras semanas de embarazo

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    Mariangel Ramos

    2013-12-01

    Full Text Available El virus de Epstein-Barr (VEB es un agente patógeno común para los humanos y su efecto en la infección vertical es poco estudiado. Durante el embarazo hay riesgo a contraer infecciones que afectan al feto. La infección adquirida antes del nacimiento ocasiona abortos, mortinatos, malformaciones, retraso en el crecimiento intrauterino, prematuridad y secuelas por infección postnatal crónica. Los efectos inmediatos o a largo plazo representan un problema a nivel mundial. Durante el embarazo se ha mostrado una prevalencia del 98% y aproximadamente el 40% de las embarazadas son susceptibles y transmitirán el virus al feto. Los actuales exámenes clínicos de rutina revelan pocos hallazgos específicos en la madre pues en su mayoría la infección por VEB tiene un curso asintomático. La poca efectividad en su tratamiento hace que la prevención y el diagnóstico sean de gran importancia. Se conoce que el VEB se mantiene latente en el 90% de los pacientes después de la infección primaria y que la infección puede ser reactivada debido a diversos factores como el estrés crónico, posiblemente debido a la disminución de la respuesta inmune celular. En la presente investigación se evaluó la prevalencia de la infección por VEB en mujeres gestantes y con aborto que se encontraban durante las primeras 15 semanas de embarazo. Las muestras de pacientes de la consulta de obstetricia en diferentes ambulatorios de los Municipios Libertador y Campo Elías del Estado Mérida y de mujeres en la sala de emergencia obstétrica del Instituto Autónomo Hospital Universitario de Los Andes (IAHULA que acudieron por aborto durante las primeras semanas, se analizaron con una prueba ELISA para la detecctar anticuerpos séricos de tipo IgG VCA-VEB que no discriminan entre una primoinfección y una infección pasada. El 35% de la población de estudio fueron 9 mujeres en gestación sin antecedente de aborto y el 65% corresponde a 17 mujeres que historia previa

  12. Programa de prevención de anemia falciforme (II: Evaluación del seguimiento de gestantes con hemoglobinas anormales

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    MarcosRaúl Martín Ruiz

    1996-04-01

    Full Text Available Algunos aspectos del Programa Cubano de Prevención de Anemia Falciforme fueron analizados en Ciudad de La Habana durante 1992. Todas las gestantes detectadas con hemoglobinas anormales fueron citadas por telegrama para explicarles el significado del hallazgo. El 62,2 % acudió con prontitud a la citación. El 21,6 % vino más tardíamente y se requirieron otros mecanismos de comunicación. El 16,2 % no acudió. Todas las gestantes que asistieron, aceptaron recibir asesoramiento genético y se hizo el seguimiento de los casos. El 47,6 % concluyó el estudio del cónyuge en tiempo útil para optar por diagnóstico prenatal. Los resultados muestran la necesidad de reducir la edad gestacional en que se determina el riesgo de la pareja. Ello sería posible mediante el pesquisaje en la primera consulta prenatal, métodos más eficientes en comunicar con las gestantes positivas, y más agilidad en la realización de los análisis y en informar los resultados.Some aspects of the Cuban Programme for Prevention of Sickle Cell Anemia were analyze in Havana City during 1992. All pregnants detected with abnormal hemoglobins received an appointment by telegram to get an explanation about the significance of findings; 62,2 % attended promptly to the appointment; 21,6 % came later, making necessary the use of other mechanisms of communication with pregnants; and 16,2 % never attended. All pregnants who went to the appointment accepted genetic counseling and were followed up. Only 47,6 % concluded testing of partner early enough for consideration of prenatal diagnosis. The results showed the need to reduce gestational age in order to determine the risk of the couple. This is possible by screaning pregnants at the first prenatal visit, by using more efficient methods for contacting with positive women, and by doing the test and informing the results faster.

  13. Factores asociados al desarrollo de preeclampsia en un hospital de Piura, Perú

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    Yamalí Benites-Condor

    2012-09-01

    Full Text Available Introducción: La Organización Mundial de la Salud indica que diariamente fallecen alrededor de 800 mujeres por causas relacionadas al embarazo y parto, dentro de las cuales la preeclampsia ocupa el tercer lugar. Objetivo: identificar los factores asociados a preeclampsia en gestantes que fueron hospitalizadas en el Hospital de Apoyo II “Santa Rosa” de la ciudad de Piura durante el periodo junio 2010 - mayo 2011. Métodos: Se realizó un estudio descriptivo retrospectivo de casos y controles, en gestantes hospitalizadas entre junio del 2010 y mayo del 2011. Mediante un muestreo aleatorio se obtuvieron 39 casos de preeclampsia y 78 controles sin preeclampsia. Los datos fueron analizados con el paquete estadístico SPSS v19.0, en el cual se ejecutó un análisis de casos y controles no pareados aplicando la prueba Chi cuadrado. Resultados: Fueron variables significativamente asociadas con la preeclampsia: Edad 35 años  (p=0,021, y número de controles prenatales mayor o igual a siete (p= 0,049. No resultaron significativos la primiparidad ni el sobrepeso. Interpretación: Se debe promover un control prenatal adecuado (traducido como siete o más controles durante la gestación, especialmente en aquellas mujeres que se encuentran en los extremos de la vida fértil.

  14. FACTORES ASOCIADOS AL DESARROLLO DE PREECLAMPSIA EN UN HOSPITAL DE PIURA, PERÚ

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    Yamalí Benites-Cóndor

    2011-01-01

    Full Text Available Introducción: La Organización Mundial de la Salud indica que diariamente fallecen alrededor de 800 mujeres por causas relacionadas al embarazo y parto, dentro de las cuales la preeclampsia ocupa el tercer lugar. Objetivo: identificar los factores asociados a preeclampsia en gestantes que fueron hospitalizadas en el Hospital de Apoyo II "Santa Rosa" de la ciudad de Piura durante el periodo junio 2010 - mayo 2011. Métodos: Se realizó un estudio descriptivo retrospectivo de casos y controles, en gestantes hospitalizadas entre junio del 2010 y mayo del 2011. Mediante un muestreo aleatorio se obtuvieron 39 casos de preeclampsia y 78 controles sin preeclampsia. Los datos fueron analizados con el paquete estadístico SPSS v19.0, en el cual se ejecutó un análisis de casos y controles no pareados aplicando la prueba Chi cuadrado. Resultados: Fueron variables significativamente asociadas con la preeclampsia: Edad 35 años (p=0,021, y número de controles prenatales mayor o igual a siete (p= 0,049. No resultaron significativos la primiparidad ni el sobrepeso. Interpretación: Se debe promover un control prenatal adecuado (traducido como siete o más controles durante la gestación, especialmente en aquellas mujeres que se encuentran en los extremos de la vida fértil.

  15. Conocimientos, actitudes y prácticas clave en gestantes con hijos menores de 5 años de la ciudad de Cúcuta, 2012

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    Doris Amparo Parada Rico

    2015-01-01

    Full Text Available Objetivo: Identificar los conocimientos, actitudes y prácticas frente al cuidado en la gestación y postparto en gestantes con hijos menores de 5 años, en Cúcuta, durante el año 2012. Metodología: Estudio cuantitativo descriptivo de corte transversal. La encuesta utilizada fue adoptada del cuestionario Prácticas Clave diseñado por la Organización Panamericana de la Salud en la estrategia Atención Integrada a las Enfermedades Prevalentes de la Infancia (AIEPI y modificada para la región norte santandereana por el Instituto Departamental de Salud. El instrumento fue validado a través de las pruebas estadísticas Alpha de Cronbach, correlación par-impar y corrección de R con ecuación de Spearman-Brown, permitiendo una evaluación más universal e identificando su validez y confiabilidad. La muestra del estudio fue de 301 participantes, quienes asistían al programa de control prenatal de tres unidades básicas del municipio. Resultados: Respecto a las características sociodemográficas, la mayoría de usuarias iniciaron su vida sexual activa en edad temprana, eran madres solteras, con escasos recursos económicos, bajo nivel educativo y convivían aún con su familia nuclear en condiciones de hacinamiento. En las categorías conocimientos, actitudes y prácticas se encontró que las gestantes, en su mayoría, poseían conocimientos adecuados frente a su cuidado en estas etapas. Sin embargo, eran discordantes con las actitudes que asumían y las prácticas aplicadas, puesto que se veían influenciadas por la cultura, las costumbres y las creencias de familiares y amigos, lo cual puede ser lesivo y tener consecuencias físicas, emocionales y económicas graves para ella, su hijo por nacer o recién nacido y su familia.

  16. Avaliação da autoestima de gestantes com uso da Escala de Autoestima de Rosenberg Evaluación de la autoestima de gestantes con uso de la escala de autoestima de Rosemberg Assessment of self-esteem in pregnant women using Rosenberg's self-esteem scale

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    Ligia Maçola

    2010-09-01

    Full Text Available O objetivo deste estudo descritivo e transversal foi avaliar a autoestima de 127 gestantes atendidas em programa de pré-natal de um hospital público de ensino. Os dados foram colhidos usando-se a Escala de Autoestima de Rosenberg; a autoestima insatisfatória foi relacionada a variáveis sócio-demográficas, de saúde da gestante e da presença ou não de sistemas de apoio. Os dados foram submetidos à análise estatística descritiva e análise univariada, buscando possíveis associações. As gestantes com autoestima insatisfatória totalizaram 60% da amostra. Em relação aos dados sócio-demográficos, as mulheres com menor escolaridade apresentaram maior frequência de escores de autoestima insatisfatória, divergindo de resultados de outros estudos. As gestantes que referiram gestação não planejada apresentaram maior prevalência de autoestima insatisfatória do que aquelas que referiram tê-la planejado. A ausência de apoio do parceiro para cuidar do filho após seu nascimento também esteve associada a menor autoestima nas grávidas. Não foram encontradas relações estatisticamente significativas para as demais variáveis estudadas.El objetivo de este estudio descriptivo y transversal fue evaluar la autoestima de 127 gestantes atendidas en el programa prenatal de un hospital público de enseñanza. Los datos fueron recolectados utilizando la Escala de Autoestima de Rosenberg; la autoestima insatisfactoria se relacionó con variables socio-demográficas, de salud de la gestante y de la existencia o no de sistemas de apoyo. Los datos fueron sometidos a análisis estadístico descriptivo y a análisis univariado, buscando posibles asociaciones. Las gestantes con autoestima insatisfactoria totalizaron el 60 % de la muestra. En relación a los datos socio-demográficos, las mujeres con menor escolarización presentaron mayor frecuencia de puntajes de autoestima insatisfactoria, divergiendo de resultados de otros estudios. Las

  17. Care cost for pregnant and parturient women with diabetes and mild hyperglycemia Costo de la asistencia de gestantes y parturientas diabéticas y con hiperglicemia leve Custo da assistência de gestantes e parturientes diabéticas e com hiperglicemia leve

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    Ana Claudia Molina Cavassini

    2012-04-01

    Full Text Available OBJECTIVE: To compare inpatient and outpatient care costs for pregnant/parturient women with diabetes and mild hyperglycemia. METHODS: A prospective observational quantitative study was conducted in the Perinatal Diabetes Center in the city of Botucatu, Southeastern Brazil, between 2007 and 2008. Direct and indirect costs and disease-specific costs (medications and tests were estimated. Thirty diet-treated pregnant women with diabetes were followed up on an outpatient basis, and 20 who required insulin therapy were hospitalized. RESULTS: The cost of diabetes disease (prenatal and delivery care was US$ 3,311.84 for inpatients and US$ 1,366.04 for outpatients. CONCLUSIONS: Direct and indirect costs as well as total prenatal care cost were higher for diabetic inpatients while delivery care costs and delivery-postpartum hospitalization were similar. Prenatal and delivery-postpartum care costs were higher for these patients compared to those paid by Brazilian National Health System.OBJETIVO: Comparar costos de hospitalización y de atención por ambulatorio en gestantes/parturientas diabéticas y con hiperglicemia leve. MÉTODOS: Estudio observacional, prospectivo, cuantitativo descriptivo realizado en centro de diabetes perinatal en Botucatu, Sureste de Brasil, entre 2007 y 2008. Se estimaron los costos por absorción directos e indirectos disponibles en la institución y los costos específicos para la enfermedad (medicamentos y exámenes. Las 30 gestantes diabéticas tratadas con dieta fueron acompañadas en ambulatorio y 20 tratadas con dieta más insulina fueron hospitalizadas. RESULTADOS: El costo de la enfermedad diabetes (para asistencia prenatal y parto fue de US$ 3,311.84 para las gestantes hospitalizadas y de US$ 1,366.04 para las acompañadas en ambulatorio. CONCLUSIONES: Los costos directos e indirectos y el costo total de la asistencia prenatal fueron más elevados en las gestantes diabéticas hospitalizadas mientras que los costos de

  18. Efectividad de la funcionalidad familiar en familias con adolescentes gestantes y adolescentes no gestantes Efetividade da funcionalidade familiar no caso de famílias de adolescentes grávidas e adolescentes não grávidas Effectiveness of family functionality in families with pregnant and non pregnant adolescents

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    Alexandra García Rueda

    2011-07-01

    Full Text Available Esta investigación tiene como objetivo comparar la evaluación de la efectividad de la funcionalidad familiar de familias con adolescentes gestantes, y no gestantes, atendidas en la Empresa Social del Estado, Instituto de Salud de Bucaramanga (ESE Isabu, durante el primer semestre de 2009. Es un estudio comparativo, transversal, cuantitativo, realizado con la participación de 77 familias con adolescentes gestantes y 104 familias con adolescentes no gestantes, en las cuales los informantes fueron de cada familia: la adolescente gestante o no gestante, y un familiar que viviera en el mismo hogar de la adolescente participante en el estudio. Para la recolección de la información se utilizó el instrumento ASF-E, de María Luisa Friedemann (1, que mide el nivel de efectividad de la funcionalidad familiar por medio de las dimensiones: cambio, mantenimiento, individuación, coherencia, y las metas: espiritualidad, crecimiento, control, estabilidad del sistema familiar. En los resultados se encontró que las familias con adolescentes gestantes presentan un nivel alto de efectividad de la funcionalidad familiar, referido por las adolescentes gestantes (49,4% y sus familiares (54,5%; mientras que las familias con adolescentes no gestantes presentan un nivel intermedio de efectividad, referido tanto por adolescentes no gestantes como por sus familiares, con igual porcentaje: 57,7%. En conclusión, existen diferencias estadísticamente significativas entre los dos grupos de familias, sobre la efectividad de la funcionalidad familiar, identificada en la prueba T con p: 0,012. Igualmente hay diferencias en las metas de estabilidad (p 0,009 y control (p 0,007 y en las dimensiones de coherencia (p 0,013 y mantenimiento del sistema familiar (p 0,033.Esta pesquisa visa comparar a avaliação da efetividade da funcionalidade familiar das famílias de adolescentes grávidas e não grávidas; atendidas na Empresa Social do Estado Instituto de Saúde de

  19. Aplicación del proceso enfermero en gestante hemodializada

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    Eloísa Fernández Ordóñez

    Full Text Available Resumen La frecuencia de las gestaciones en mujeres en tratamiento con hemodiálisis está incrementándose en los últimos años. El aumento de fertilidad en estas pacientes se debe a la mejora de la eficacia de la diálisis, junto con el manejo clínico de la insuficiencia renal. Sin embargo, el embarazo de las pacientes hemodializadas sigue siendo un reto, debido a frecuentes complicaciones como la preeclampsia, la prematuridad severa, el polihidramnios, etc. Actualmente, se constata el ascenso de la tasa de supervivencia fetal y la disminución de la morbi-mortalidad materno-fetal. Presentamos el caso de una gestante en tratamiento con hemodiálisis que presenta una amenaza de parto prematuro a la 27+2 semanas de gestación. Se han formulado diagnósticos enfermeros siguiendo la taxonomía NANDA-NOC-NIC, con la finalidad de visibilizar la necesidad de un adecuado plan de cuidados en estas pacientes.

  20. Efecto de la infección aguda con Trypanosoma cruzi sobre el sistema nervioso central de rata gestante

    OpenAIRE

    Lugo de Yarbuh, Ana; Rondón, Johan; Alarcón, Maritza; Moreno, Elio; Araujo, Sonia

    2009-01-01

    Este estudio analizó el efecto de la infección aguda con Trypanosoma cruzi sobre la histología del sistema nervioso central de ratas durante la gestación. Las ratas Wistar fueron infectadas por inoculación intraperitoneal de 5x10(4) tripanosomas sanguícolas de la cepa M/HOM/Bra/53/Y. Para obtener la preñez durante el ascenso de la parasitemia, las ratas en estrus del ciclo menstrual fueron apareadas con los machos a los 12 días posinfección (pi). Ratas vírgenes/infectadas, vírgenes/sanas y sa...

  1. Niveles de ácido úrico sérico y riesgo de desarrollar preeclampsia

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    Ana I Corominas

    2014-12-01

    Full Text Available Si bien se conoce que existe una asociación entre los niveles elevados de ácido úrico y la preeclampsia, el debate sobre su aplicación clínica aún está abierto. Nuestro objetivo fue estudiar la utilidad del dosaje periódico del ácido úrico sérico durante el embarazo para identificar gestantes con mayor riesgo de desarrollar preeclampsia. Realizamos un estudio retrospectivo en gestantes primíparas: 79 normotensas y 79 con preeclampsia atendidas en el Hospital Nacional Posadas durante el año 2010. Se analizaron los niveles séricos de ácido úrico, creatinina y urea, y los datos de proteinuria de las historias clínicas de las mujeres embarazadas. Los niveles de ácido úrico fueron similares en ambos grupos durante la primera mitad de la gestación. Sin embargo, a partir de la semana 20, el ácido úrico se incrementó 1.5 veces en gestantes preeclámpticas, sin cambios en la uremia y creatininemia, descartándose así el compromiso renal. Además, encontramos que niveles más altos de ácido úrico se correlacionaban con bajo peso del recién nacido. También vimos que las gestantes con antecedentes familiares de hipertensión eran más propensas a desarrollar esta condición. Por otro lado, no observamos una relación directa ni con el sexo fetal ni con el tiempo de aparición de los síntomas clínicos. Estos hallazgos sugieren que los cambios en las concentraciones de ácido úrico se deberían a alteraciones en los estadios iniciales de la preeclampsia. Por ello, la monitorización de los niveles del mismo durante el embarazo podría contribuir al abordaje precoz de este desorden gestacional.

  2. Hidropesía fetal en una gestante con enfermedad hipertensiva grave. Presentación de un caso

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    Maribel Rodríguez Matos

    2013-09-01

    Full Text Available La hidropesía fetal es un grave proceso de elevada mortalidad perinatal, de etiología multifactorial, caracterizado por un síndrome edematoso generalizado, con o sin acumulación de líquido en las cavidades serosas del organismo fetal. Se presenta un caso de hidropesía fetal no inmunológica en una paciente de sexo femenino, de color de piel blanca y de 20 años de edad con enfermedad hipertensiva grave, diagnosticada mediante ultrasonido, como estudio de bienestar fetal a las 35,1 semanas de gestación, cuando fue remitida desde su área de salud por presentar cifras de tensión arterial de 160/100 mmHg. A su llegada al cuerpo de guardia de ginecobstetricia del hospital Héroes del Baire de la Isla de la Juventud se constataron cifras de 140/90 mmHg, se presentaba asintomática, por lo que se ingresó para estudio y tratamiento. Teniendo en cuenta el examen físico y el resultado del ultrasonido obstétrico, se decidió la interrupción de embarazo por cesárea de urgencia. Se recibió un recién nacido pretérmino de aspecto malformado. Se decide la presentación del caso por lo poco común de esta patología asociada a una enfermedad hipertensiva grave lo que incrementa el riesgo perinatal.

  3. Gestantes/puérperas com hiv/aids: conhecendo os déficits e os fatores que contribuem no engajamento para o autocuidado Gestantes/puérperas con el vih/sida: conociendo los déficits y los factores que contribuyen para el compromiso con el autocuidado Pregnant women/mothers with newborns with hiv/aids: understanding the deficits and factors that contribute to engaging in self-care

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    Lígia Maria Scherer

    2009-06-01

    Full Text Available Trata-se uma pesquisa qualitativa do tipo exploratório-descritiva cujo objetivo foi conhecer os déficits de autocuidado de gestantes/puérperas com HIV/AIDS e os fatores que influenciam no engajamento para o autocuidado. O estudo foi realizado com dez gestantes/puérperas com HIV que utilizam um serviço especializado em DST/AIDS no Rio Grande do Sul. Os dados foram coletados por meio de um grupo focal e entrevistas individuais, com um roteiro semiestruturado. Após análise dos dados, utilizando-se a análise de conteúdo, chegou-se aos seguintes resultados: as gestantes/puérperas com HIV apresentam déficits de autocuidado relacionados com a alimentação, ingesta hídrica, sono e repouso, vida sexual, lazer e recreação e interação social. Convivem tanto com fatores que contribuem para o engajamento no autocuidado quanto com fatores que o dificultam. Embora com dificuldades, as gestantes/puérperas têm conseguido sobreviver ao isolamento e ao preconceito graças ao apoio familiar e da equipe de saúde, em especial das enfermeiras.Se trata de una investigación de carácter cualitativo, exploratoria descriptiva, cuyo objetivo fue conocer las faltas con el autocuidado de las gestantes/puérperas con VIH/SIDA, así como los factores que contribuyen para su compromiso con ese autocuidado. El estudio fue realizado con diez gestantes/puérperas con VIH/SIDA que utilizaron un servicio especializado en DST/SIDA, en el Estado de Rio Grande do Sul Brasil. Los datos fueron colectados a través de sesiones de grupo, y también por medio de entrevistas individuales con un esquema parcialmente elaborado. Después de realizar el análisis de los datos, utilizando para ello el análisis del contenido, se obtuvieron los siguientes resultados: las gestantes/puérperas con VIH presentan dificultades en el autocuidado que están relacionadas con la alimentación, la ingestión de líquidos, sueño y descanso, vida sexual, ocio, recreación, e integraci

  4. Anestesia em gestante com hipertensão intracraniana por meningite tuberculosa: relato de caso Anestesia en gestante con hipertensión intracraneal por meningitis tísica: relato de caso Anesthesia in pregnant patient with intracranial hypertension due to tuberculous meningitis: case report

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    Vanessa Breitenbach

    2005-02-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: Está bem estabelecido que a técnica anestésica de escolha para cesariana eletiva é a anestesia regional. Porém, em gestantes com hipertensão intracraniana e infecção do sistema nervoso central esta técnica deve ser evitada. O objetivo deste artigo é relatar o manejo anestésico de uma gestante, com hipertensão intracraniana secundária à meningite tuberculosa, que foi submetida à cesariana eletiva. RELATO DO CASO: Paciente branca, 32 anos, 60 kg, 1,62 m de estatura, na 36ªsemana de idade gestacional, agendada para interrupção cirúrgica da gestação por apresentar-se tetraparética, com hidrocefalia decorrente de meningite tuberculosa. Escolheu-se a anestesia geral para a cesariana com indução em seqüência rápida e manobra de Sellick para a intubação traqueal. As drogas utilizadas foram tiopental (250 mg, rocurônio (50 mg, fentanil (100 µg e lidocaína (60 mg por via venosa. A indução anestésica foi suave e mantida com isoflurano até o início do fechamento da pele da paciente, com mínimas alterações de seus sinais vitais e do recém-nascido, que recebeu índice de Apgar 8 e 9, no 1º e 5º minutos, respectivamente. A paciente despertou precocemente, sem deficits neurológicos adicionais. CONCLUSÕES: A anestesia geral ainda é a técnica anestésica preferida para cesariana em gestantes com hipertensão intracraniana, utilizando-se drogas de meia-vida curta e que tenham mínima interferência na pressão intracraniana e no recém-nascido.JUSTIFICATIVA Y OBJETIVOS: Está bien establecido que la técnica anestésica de elección para cesárea electiva es la anestesia regional. Sin embargo, en gestantes con hipertensión intracraneal e infección del sistema nervioso central esta técnica debe ser evitada. El objetivo de este artículo es relatar el manejo anestésico de una gestante, con hipertensión intracraneal secundaria a la meningitis tísica, que fue sometida a la ces

  5. Anemia em gestantes brasileiras antes e após a fortificação das farinhas com ferro Anemia en gestantes brasileñas antes y después de la fortificación de harinas con hierro Anemia in Brazilian pregnant women before and after flour fortification with iron

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    Elizabeth Fujimori

    2011-12-01

    Full Text Available OBJETIVO: Comparar prevalência de anemia e valores de hemoglobina (Hb em gestantes brasileiras, antes e após a fortificação das farinhas com ferro. MÉTODOS: Estudo de avaliação de painéis repetidos, desenvolvido em serviços públicos de saúde de municípios das cinco regiões brasileiras. Dados retrospectivos foram obtidos de 12.119 prontuários de gestantes distribuídas em dois grupos: antes da fortificação, com parto anterior a junho de 2004, e após a fortificação, com última menstruação após junho de 2005. Anemia foi definida como Hb OBJETIVO: Comparar prevalencia de anemia y valores de hemoglobina (Hb en gestantes brasileñas, antes y después de la fortificación de las harinas con hierro. MÉTODOS: Estudio de evaluación de paneles repetidos, desarrollado en servicios públicos de salud de municipios de las cinco regiones brasileñas. Datos retrospectivos se obtuvieron de 12.119 prontuarios de gestantes distribuidas en dos grupos: antes de la fortificación, con parto anterior a junio de 2004, y posterior a la fortificación, con última menstruación después de junio 2005. Anemia fue definida como HbOBJECTIVE: To compare prevalence of anemia and hemoglobin (Hb levels in Brazilian pregnant women before and after flour fortification with iron. METHODS: A repeated cross-sectional panel study of public health care centers of municipalities in the five Brazilian regions was conducted. Retrospective data were obtained from 12,119 medical records of pregnant women distributed in two groups: before fortification (delivery prior to June 2004 and after fortification (date of last period after June 2005. Anemia was defined as Hb<11.0 g/dl. Hb levels according to gestational age were assessed using two references from the literature. Statistical analysis was carried out using chi-squared tests, Student's t tests, and logistic regression, with a significance level of 5%. RESULTS: In the total sample, prevalence of anemia fell from

  6. THE OCCURRENCE OF PRE-ECLAMPSIA IN WOMEN PREGNANT FOR THE FIRST TIME ATTENDING PRENATAL CARE CONSULTATION AT A UNIVERSITY HOSPITAL

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    Thelma Spindola

    2013-05-01

    Objetivos. Conocer el  perfil de las gestantes primigestas atendidas en el pre-natal; identificar la incidencia de pre-eclampsia en gestantes primigestas atendidas en consultas del pre-natal y discutir la contribución del enfermero obstetra en la detección precoz de interconsultas durante el embarazo. Método: Estudio descriptivo, cuantitativo, retrospectivo, realizado en uno de los Hospitales Universitarios de Rio de Janeiro. Las historias clínicas de primigestas atendidas desde 2008 a 2009 fueron analizados con apoyo de la estadística descriptiva. Resultados: Fueron 264 (56,3% internaciones de primigestas, fueron parte del conjunto de muestra 105 historias clínicas.  En este grupo investigado, 43(40,9% gestantes no presentaron edema; 2 (1,9% tuvieron proteinuria e 29 (27,6 % no tuvieron anormalidades en los controles de presión arterial. Conclusión: En la muestra no hubo registro de pre-eclampsia, además 41 (38,9% mujeres presentaron alteraciones de presión arterial compatibles con  Enfermedad Hipertensiva Específica de la Gestación (EHEG. El enfermero tiene un papel importante en el equipo multi-profesional para la detección precoz de complicaciones en la gestación contribuyendo para la reducción de la incidencia de morbimortalidad.

  7. Descubriendo las prácticas de cuidado de adolescentes gestantes con infección vaginal Descobrindo as práticas de cuidado de adolescentes gestantes com infecção vaginal Discovering care practices of pregnant adolescents with vaginal infection

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    MARY LUZ MONROY RUBIANO

    Full Text Available El estudio tuvo como objetivo descubrir el significado de cuidado a partir de prácticas y creencias culturales de las adolescentes gestantes con diagnóstico de infección vaginal que asistieron a control prenatal en la ESE Hospital San Rafael de Girardot en el primer trimestre de 2007. Diseño cualitativo de tipo etnográfico, basado en la etnoenfermería de la teoría transcultural de Leininger. Se empleó la entrevista y el análisis etnográfico de Spradley y se realizaron en promedio tres entrevistas a cada una de las 7 informantes, hasta que hubo saturación de información. La muestra estuvo representada por la calidad de la información brindada. A partir del análisis a profundidad se construyeron tres dominios y taxonomías: 1. conocimiento de la infección vaginal, 2. acciones de protección, 3. consejos recibidos. El estudio reveló que las adolescentes gestantes tenían conocimientos sobre la infección vaginal, sus causas y consecuencias. Cuidarse representó poner en práctica los consejos recibidos de las fuentes informales y formales para que desapareciera la infección vaginal, evitar la reinfección y las complicaciones para ellas y el hijo por nacer. Para las adolescentes gestantes, cuidarse durante la infección vaginal representó poner en práctica los consejos recibidos de las fuentes informales y formales para que desapareciera la infección vaginal y evitar la reinfección y las complicaciones para ellas y el hijo por nacer. Se evidenciaron las diferentes formas que tenían de conocer y establecer prácticas de cuidado durante la infección vaginal y se resaltó la ausencia de consejos formales del profesional de enfermería.O estudo visa descobrir o significado de cuidado a partir de práticas e crenças culturais das adolescentes gestantes com diagnóstico de infecção vaginal que se apresentaram no posto de controle prénatal da ESE Hospital San Rafael de Girardot durante o primeiro trimestre de 2007. Desenho

  8. Descubriendo las prácticas de cuidado de adolescentes gestantes con infección vaginal Discovering care practices of pregnant adolescents with vaginal infection Descobrindo as práticas de cuidado de adolescentes gestantes com infecção vaginal

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    MUÑOZ DE RODRÍGUEZ LUCY

    2009-12-01

    Full Text Available El estudio tuvo como objetivo descubrir el significado de cuidado a partir de prácticas y creencias culturales de las adolescentes gestantes con diagnóstico de infección vaginal que asistieron a control prenatal en la ESE Hospital SanRafael de Girardot en el primer trimestre de 2007. Diseño cualitativo de tipo etnográfico, basado en la etnoenfermería de la teoría transcultural de Leininger. Se empleó la entrevista y el análisis etnográfico de Spradley y se realizaron en promedio tres entrevistas a cada una de las 7 informantes, hasta que hubo saturación de información. La muestra estuvo representada por la calidad de la información brindada. A partir del análisis a profundidad se construyeron tres dominios y taxonomías: 1. conocimiento de la infección vaginal, 2. acciones de protección, 3. consejos recibidos. El estudio reveló que las adolescentes gestantes tenían conocimientos sobre la infección vaginal, sus causas y consecuencias. Cuidarse representó poner en práctica los consejos recibidos de las fuentes informales y formales para que desapareciera la infección vaginal, evitar la reinfección y las complicaciones para ellas y el hijo por nacer. Para las adolescentes gestantes, cuidarse durante la infección vaginal representó poner en práctica los consejos recibidos de las fuentes informales y formales para que desapareciera la infección vaginal y evitar la reinfección y las complicaciones para ellas y el hijo por nacer. Se evidenciaron las diferentes formas que tenían de conocer y establecer prácticas de cuidado durante la infección vaginal y se resaltó la ausencia de consejos formales del profesional de enfermería.The study was aimed at discovering the meaning of care from the perspective of cultural beliefs and customs of pregnant adolescents with vaginal infection diagnosis who had pre-natal control at the ESE Hospital San Rafael of the city of Girardot during the first quarter of 2007. Qualitative

  9. Consulta de enfermagem a gestantes com anemia ferropriva Consulta de enfermería a mujeres embarazadas con anemia ferropénica Nursing care to pregnant women with iron deficiency anemia

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    Sonia Maria Oliveira de Barros

    1999-10-01

    Full Text Available Este trabalho teve como objetivos: construir um protocolo de levantamento de dados e diagnósticos de enfermagem, e conhecer os diagnósticos de enfermagem mais freqüentes. O protocolo construído foi aplicado em 52 consultas de enfermagem para as gestantes que apresentavam valores de hemoglobina menores que 11,0g/dl. Os diagnósticos de enfermagem mais freqüentes foram: nutrição alterada, risco para infecção, manutenção do lar prejudicada; déficit de conhecimento sobre a alimentação, risco para lesão fetal relacionada a diminuição da perfusão útero-placentária.; risco de não-comprometimento. A partir dos diagnósticos de enfermagem foram planejadas as intervenções e os resultados esperados com a sua aplicação.Realizamos este trabajo con los siguientes objetivos: construir un protocolo de levantamiento de datos y conocer los diagnósticos de enfermería más frecuentes entre las mujeres embarazadas con anemia ferropénica. El protocolo fue aplicado en 52 consultas de enfermería para las gestantes que presentaban valores de hemoglobina abajo de 11,0 g/dl. Los diagnósticos de enfermería más frecuentes fueron: nutrición alterada, riesgo de infección, manutención del hogar perjudicada, déficit de conocimiento sobre la alimentación, riesgo de lesión fetal relacionada con la disminución de perfusión útero-placentária, riesgo de no comprometimiento. A partir de los diagnósticos de enfermería fueron planeadas las intervenciones y los resultados esperados con su aplicación.This study was carried out with the following objectives: to set up a protocol of data survey and nursing diagnosis, and to detect the most frequent nursing diagnosis among pregnant women with iron deficiency anemia. The protocol was applied in 52 nursing visits to pregnant women who presented hemoglobin values lower than 11.0g/dl.The most frequent nursing diagnosis were: altered nutrition, risk to infection, impaired maintenance of the home

  10. Enfermedad hipertensiva en la gestante: Resultados de un servicio Hypertensive disease in the pregnant woman: Results of a service

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    Vivian Asunción Álvarez Ponce

    2008-09-01

    Full Text Available La preeclampsia constituye una de las principales causas de mortalidad materna en el mundo. Se realizó un estudio retrospectivo, longitudinal y descriptivo en el Hospital Docente Ginecoobstétrico de Guanabacoa de los años 2004 y 2005, de todas las gestantes que ingresaron en la Sala de Cuidados Perinatales, clasificadas como hipertensas, y que tuvieron su parto en igual período. El grupo estudio correspondió a 71 pacientes. Se tomó como grupo control igual número de gestantes que tuvieron su parto en el mismo período, y que no eran hipertensas ni presentaron la enfermedad durante la gestación. Predominó la preeclampsia como entidad única o asociada a una hipertensión crónica. Entre los factores de riesgo fueron más frecuentes la nuliparidad con un 45,1 %, el sobrepeso y la obesidad (22,5 y 25,4 % respectivamente, lo cual resultó de gran significación estadística. Fue significativa la diferencia en el parto por cesárea (77,5 % en el grupo estudio, en relación con el parto transpelviano. También el bajo peso tuvo diferencias estadísticas significativas (21,1 %. La morbilidad materna fue baja.Preeclampsia is one of the main causes of maternal mortality in the world. A retrospective, longitudinal and descriptive study was conducted in the Gynecoobstetric Hospital of Guanabacoa in 2004 and 2005. All the expectants admitted in the Perinatal Care Ward that were classified as hypertensive and that delivered in the same period were studied. The study group was composed of 71 patients. The same number of pregnant women that gave birth during this period were included in the control group. They were not hypertensive and and they did not suffer from this disease during pregnancy. Preeclampsia predominated as a unique entity or associated with chronic hypertension.The most common risk factors were nuliparity with 45.1 %, overweight and obesity (22.5 and 25.4 %, respectively, which had a great statistical significance. In the study group

  11. Preeclampsia grave: características y consecuencias

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    Arturo Pérez de Villa Amil Álvarez

    2015-07-01

    Full Text Available Fundamento: la preeclampsia es un trastorno hipertensivo del embarazo y es una de las principales causas de morbimortalidad perinatal y materna. Objetivo: identificar los factores maternos, terapéuticos, y daños asociados a la preeclampsia grave en gestantes. Método: estudio de serie de casos, que incluyó 69 pacientes diagnosticadas con preeclampsia grave en el período del 1ro de enero de 2012 al 31 de diciembre de 2013, atendidas en el Hospital General Universitario Dr. Gustavo Aldereguía Lima. Se clasificaron en dos grupos correspondiendo ambos a los criterios de preeclampsia grave con y sin asociación de factores agravantes. Se evaluaron variables relacionadas a: características maternas, características de atención médica, características neonatales y fetales. Se aplicó un formulario confeccionado según los datos obtenidos de las historias clínicas, acorde a la Clasificación Internacional de Enfermedades Décima Revisión. Las comparaciones entre grupos se efectuaron por el estadístico X2 aceptándose como significativo una p<0,05. Resultados: la frecuencia de preeclampsia grave fue de 0,8x100 partos. La mayor frecuencia correspondió al rango de edad de 31-35 años. La eclampsia se observó en 0,91x1000 partos. El daño materno ascendió a 30,4 %. El sulfato de magnesio se utilizó como profilaxis en el 89 % de los casos. La frecuencia de eclampsia en las que no se usó fue del 50 %, mientras que en las que se usó fue de solo 6,4 %. La cesárea se realizó en el 85,5 % de las pacientes. El daño neonatal se asoció al 52,3 %. La mortalidad fetal tardía fue de 4,6x100 nacimientos. En las diferencias intergrupos se observaron divergencias significativas respecto al daño neonatal. Conclusión: es evidente la alta asociación de restricción del crecimiento intrauterino con la prematuridad inducida, alto índice de cesárea primitiva y el elevado daño materno, neonatal y fetal. El uso del sulfato de magnesio impresiona con

  12. Preeclampsia como factor de riesgo independiente para el trastorno por déficit de atención con hiperactividad. Estudio de casos y controles. Bucaramanga, Colombia

    OpenAIRE

    Yuly Andrea Castellanos-Castellanos; Mauricio Escobar-Sánchez; María Carolina Páez-Leal; Luis Alfonso Díaz-Martínez; Carlos Andrés Arias-Duran; Derlly Marcela Espitia-Orejarena; Jesica Lisette Forero-Parada

    2014-01-01

    Introducción: El trastorno por déficit de atención e hiperactividad es una condición mental que afecta a niños y adolescentes con prevalencia estimada de 5.3% en la población mundial y en Colombia es de 19-24% en hombres y 10-12% en mujeres. Su etiología es multifactorial, entre ellos se encuentra la hipoxia como factor del medio ambiente uterino; presentándose en entidades como la preeclampsia, donde se ha considerado determinante en el desarrollo del trastorno por dé...

  13. Cuando la preeclampsia irrumpe inesperadamente en el embarazo: Dolor, miedo y fe en Dios When preeclampsia bursts into pregnancy: Pain, fear, and faith in God

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    Celmira Laza Vásquez

    2012-12-01

    Full Text Available La preeclampsia es la alteración de mayor frecuencia durante la gestación y el puerperio, ocasionando una alta morbilidad en el binomio madre-hijo. Sin embargo, las consecuencias de ésta no deben valorarse solo teniendo en cuenta las alteraciones en la salud que ocasiona en la mujer y su hijo, sino también en términos de lo difícil y doloroso que puede ser la vivencia para las gestantes que han tenido que enfrentarse a esta enfermedad. Este es el relato biográfico de una joven estudiante de enfermería que describe su experiencia de enfrentarse a la preeclampsia durante su primera gestación, cuando ésta irrumpió inesperadamente en su anhelada maternidad, generando miedo y angustia por la gravedad que para ella significó la enfermedad y la posibilidad de la muerte de su hija junto con la experiencia de una larga hospitalización. La fe en Dios y la presencia de su compañero se constituyeron en soporte para sobrellevar los amargos momentos vividos.Preeclampsia is the most frequent disease during pregnancy and delivery, causing high morbidity to the maternofetal unit. However, the difficult, painful life experiences of pregnant women who suffered preeclampsia must be kept in mind, beyond their health alterations. This paper offers the biographical account of a young nursery student, who describes her experience while engaging preeclampsia in her first pregnancy, when disease abruptly stopped her much desired maternity, causing to her fear, distress, and a long hospitalization. God and his mate were her support while leaving behind her bitter experience.

  14. Evaluación del perfil metabólico lipídico en cerdas gestantes y su relación con la nutrición fetal

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    Pamela Duque G.

    2013-08-01

    Full Text Available Objetivo. Evaluar el metabolismo lipídico de cerdas gestantes como respuesta a la modificación del nivel graso de la dieta y su efecto sobre la nutrición fetal a través de indicadores metabólicos. Materiales y métodos. Cincuenta y seis cerdas gestantes primíparas o multíparas se seleccionaron para suministrarles una dieta sin adición de grasa extra (SAp o SAm o con adición de grasa extra (AGp o AGm. La dieta SA consistió en suministrar 3 kg/día de una dieta comercial convencional, en la dieta AG se redujo el maíz y se incluyó aceite de soya para proporcionar 20% de grasa extra. Las muestras sanguíneas se colectaron a los 85, 100, 113 días de gestación y a las 24 horas posparto, asimismo, al 50% de los lechones nacidos vivos de cada camada. Se analizaron concentraciones séricas de colesterol (CT, triglicéridos (TG, lipoproteínas de alta (HDL y baja densidad (LDL, ácidos grasos no esterificados (NEFA y betahidroxibutirato (BHB. Resultados. Las concentraciones séricas de HDL, LDL, CT, NEFA, BHB y TG, (p<0.01 aumentaron tanto en las cerdas primíparas como multíparas al día 100 y 113, pero disminuyeron a las 24 horas posparto. Los metabolitos sanguíneos en los lechones bajo la influencia de los dos tratamientos presentaron diferencias significativas (p<0.01. Conclusiones. No se encontró efecto de la modificación de la grasa en la dieta sobre LDL y NEFA; para los restantes indicadores se presentó diferencia en las cerdas en gestación. No se encontró correlación entre los indicadores metabólicos de las madres y los lechones.

  15. Preeclampsia como factor de riesgo independiente para el trastorno por déficit de atención con hiperactividad. Estudio de casos y controles. Bucaramanga, Colombia

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    Yuly Andrea Castellanos-Castellanos

    2014-07-01

    Full Text Available Introducción: El trastorno por déficit de atención e hiperactividad es una condición mental que afecta a niños y adolescentes con prevalencia estimada de 5.3% en la población mundial y en Colombia es de 19-24% en hombres y 10-12% en mujeres. Su etiología es multifactorial, entre ellos se encuentra la hipoxia como factor del medio ambiente uterino; presentándose en entidades como la preeclampsia, donde se ha considerado determinante en el desarrollo del trastorno por déficit de atención e hiperactividad, siendo importante evaluar su asociación. Objetivo: Determinar la asociación entre el diagnóstico trastorno por déficit de atención e hiperactividad y el antecedente perinatal de preeclampsia. Metodología: Estudio de casos y controles retrospectivo de 411 casos de trastorno por déficit de atención e hiperactividad y 404 controles no emparentados sin trastorno ni otros trastornos disruptivos del comportamiento. La evaluación psiquiátrica se hizo entre el 2005–2011, mediante entrevista estructurada que incluyó indagar el antecedente de preeclamsia en el embarazo de cada paciente. Resultados: El antecedente de preeclampsia se presentó en el 3.7% de los pacientes con trastorno por déficit de atención e hiperactividad y en el 5.5% de los controles (OR 0.66, IC95% 0.34 – 1.29; p=0.221. Esta falta de asociación se mantuvo luego de ajustar por género, ser adoptado, haber nacido por cesárea y edad de inicio del trastorno que llevó a consultar al paciente (OR 0.51, IC95% 0.22 – 1.17; p=0.115. Conclusión: El estudio no encontró significancia estadística entre el antecedente de preeclampsia materna y el trastorno por déficit de atención e hiperactividad como factor principalmente asociado en la muestra de pacientes seleccionados.

  16. Violência sexual e associação com a percepção individual de saúde entre mulheres gestantes Violencia sexual y asociación con la percepción individual de salud entre mujeres gestantes Sexual violence and its association with health self-perception among pregnant women

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    Nicole Moraes Rêgo De Aquino

    2009-12-01

    Full Text Available OBJETIVO: Estimar a prevalência de histórico de violência sexual entre mulheres gestantes e sua associação com a percepção de saúde. MÉTODOS: Estudo transversal, com 179 mulheres maiores de 14 anos e grávidas de 14 a 28 semanas, entrevistadas em serviços públicos de saúde em São Paulo, SP, entre os anos de 2006 e 2007. Os instrumentos utilizados foram: inventário de violência sexual, inventário de dados sociodemográficos e questionário de qualidade de vida relacionada à saúde: "Medical Outcomes 12-Item Short-Form Health Survey" (SF-12®. Mulheres com e sem história de violência sexual foram comparadas quanto à idade, escolaridade, ocupação, estado civil, cor da pele e autopercepção de saúde física e mental. A violência sexual foi caracterizada em penetrativa ou não penetrativa. RESULTADOS: Houve prevalência de 39,1% de violência sexual entre as entrevistadas, sendo 20% do tipo penetrativo, cometida sobretudo por agressores conhecidos. Em 57% das mulheres a primeira agressão ocorreu antes dos 14 anos. Não houve diferenças sociodemográficas entre mulheres que sofreram e as que não sofreram violência sexual. Escores médios de percepção de saúde física entre as entrevistadas com antecedente de violência sexual foram menores (42,2; DP=8,3 do que das mulheres sem este antecedente (51,0; DP=7,5 (pOBJETIVO: Estimar la prevalencia de histórico de violencia sexual entre mujeres gestantes y su asociación con la percepción de salud. MÉTODOS: Estudio transversal, con 179 mujeres mayores de 14 años y embarazadas de 14 a 28 semanas, entrevistadas en servicios públicos de salud en Sao Paulo, Sureste de Brasil, entre los años de 2006 y 2007. Los instrumentos utilizados fueron: inventario de violencia sexual, inventario de datos sociodemográficos y cuestionario de calidad de vida relacionada con la salud: "Medical Outcomes 12-Item Short-Form Health Survey" (SF-12 ®. Mujeres con y sin historia de violencia

  17. Prácticas de cuidado que hacen las gestantes adolescentes consigo mismas y con el hijo por nacer. Self-care practices among pregnant teenagers and to their unborn baby

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    Lina María Granados Oliveros, Enf

    2011-01-01

    Full Text Available Objetivo: Se desarrolló un estudio descriptivo con abordaje cuantitativo con el objetivo de valorar y describir las prácticas de cuidado que realizan consigo mismas y con el hijo por nacer de 150 gestantes adolescentes que asisten al Hospital Local del Norte de la ciudad de Bucaramanga, durante el primer trimestre del 2008. Metodología: Se empleó el instrumento “Prácticas de cuidado que realizan consigo mismas y con el hijo por nacer las mujeres en etapa prenatal”, desarrollado por el grupo de cuidado materno perinatal de la Universidad Nacional de Colombia. Resultados: El promedio de edad de las participantes fue de 17.2 años; predomina la unión libre (68.0%, el 59.3% tienen secundaria incompleta, 70.7% se dedican a ser amas de casa y 64.7% dependen económicamente del esposo. En cuanto a las dimensiones evaluadas con el instrumento, la estimulación prenatal tiene regular práctica de cuidado: estimulación auditiva (52.6% y táctil (72.3%. En ejercicio y descanso la práctica es regular (52.0% no dedica tiempo para realizar ejercicio físico a la semana. En higiene y cuidados personales tienen buena práctica (48.6% siempre se cepilla los dientes después de cada comida, al igual que en la alimentación (51.3%, mientras que el 40.0% consumen siempre los requerimientos de calcio al día. En sistemas de apoyo hay buenas prácticas de cuidado, dado que el 62.0% buscan apoyo económico de la familia. Finalmente, en la dimensión sustancias no beneficiosas hay buenas prácticas de cuidado (65.3% las evitan. En general, entre la población estudiada las prácticas de cuidado de las gestantes adolescentes son regulares en el 67.3% de estas. Conclusión: Estos datos permiten iniciar la planeación de estrategias adecuadas de educación y capaciación sobre la forma adecuada de cuidarse ellas mismas y el hijo por nacer en este grupo poblacional, para de esta manera reducir la morbilidad y mortalidad en las adolescentes gestantes

  18. Polimorfismo en el gen COMT en una muestra de gestantes normales y con restricción del crecimiento intrauterino en un hospital de Lima

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    José Pacheco-Romero

    2013-04-01

    Full Text Available Antecedentes: Los procesos fisiopatológicos que ocurren a nivel celular y molecular en la restricción de crecimiento intrauterino (RCIU son aún desconocidos. La catecol-O-metiltransferasa (COMT es una enzima de fase II que inactiva los catecol estrógenos al transferir un grupo metílico. Se conoce un polimorfismo funcional Val158 Met en el gen COMT como un marcador susceptible para diversas enfermedades maternoperinatales, existiendo estudios que sugieren que el alelo que codifica una COMT de baja actividad puede ser un marcador susceptible para RCIU. Por lo tanto, el estudio del polimorfismo COMT ofrece una nueva estrategia para la evaluación de marcadores genéticos que pueden ser utilizados para la detección de ciertas alteraciones asociadas al embarazo. Objetivos: Establecer la asociación entre el polimorfismo Val158Met catecol-O-metiltransferasa (COMT y la restricción de crecimiento intrauterino. Institución: Facultad de Medicina, Universidad Nacional Mayor de San Marcos, Lima, Perú. Diseño: Estudio tipo relacional (asociativo, con diseño observacional, tipo caso-control (no experimental. Materiales: Muestra de sangre materna de parturientas. Métodos: Durante el año 2011, se obtuvo 81 muestras para genotipaje del gen COMT. De ellas, 26 (32,1% correspondieron a parturientas con RCIU (casos y 55 (67,9% a muestras de madres de hijos sin RCIU (controles. La distribución de los genotipos fue evaluada usando la prueba de chi cuadrado. Se comprobó la distribución proporcional de los genotipos en los grupos con RCIU y sin RCIU con la hipótesis nula de Hardy-Weinberg. Las madres participantes firmaron un consentimiento informado. Principales medidas de resultados: Asociación entre los genotipos COMT y la RCIU, y entre los alelos COMT Val/Met y la RCIU. Resultados: Las distribuciones de los genotipos en los grupos con RCIU y sin RCIU estuvieron de acuerdo a la hipótesis nula de Hardy-Weinberg. Al relacionar los genotipos COMT Val

  19. Preeclampsia 2012

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    Elosha Eiland

    2012-01-01

    Full Text Available Preeclampsia is a common complication of pregnancy associated with high maternal morbidity and mortality and intrauterine fetal growth restriction. There is extensive evidence that the reduction of uteroplacental blood flow in this syndrome results from the toxic combination of hypoxia, imbalance of angiogenic and antiangiogenic factors, inflammation, and deranged immunity. Women treated for preeclampsia also have an increased risk for cardiovascular and renal disease. At present it is unclear if the increased cardiovascular and renal disease risks are due to residual and or progressive effects of endothelial damage from the preeclampsia or from shared risk factors between preeclampsia and cardiac disease. Moreover, it appears that endothelin-1 signaling may play a central role in the hypertension associated with preeclampsia. In this paper, we discuss emerging data on the pathogenesis of preeclampsia and review therapeutic options.

  20. Conocimiento de la enfermera en la atención a usuario con pre-eclampsia y eclampsia.

    OpenAIRE

    González Heras, NP.; Ballardo Mendoza, M.G.; Domínguez Luna, IF.; Magaña Ramírez, S.; Molina Heras, OA.; Uriarte Ontiveros, S.

    2008-01-01

    Introducción La preeclampsia-eclampsia continúa siendo una de las principales causas de morbilidad y mortalidad perinatal en todo el mundo. En México ha sido la primera causa de muerte materna en los últimos 20 años a pesar de los avances en calidad y cantidad de control prenatal, de la atención del parto y puerperio. (1-2). Objetivo Identificar el nivel de conocimiento que tiene el personal de enfermería del área de Tococirugía y Ginecoobstetricia en la atención a...

  1. Fatores associados ao acesso anterior à gestação a serviços de saúde por adolescentes gestantes Factores asociados con el acceso anterior a la gestación a los servicios de salud por adolescentes gestantes Factors associated with access to health services prior to pregnancy by pregnant adolescents

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    Ingrid Espejo Carvacho

    2008-10-01

    Full Text Available OBJETIVO: Analisar os fatores determinantes do acesso de adolescentes gestantes a serviços de atenção primária à saúde, anterior à ocorrência da gestação. MÉTODOS: Estudo transversal baseado em referencial teórico. O acesso a serviços foi analisado em cinco dimensões: geográfico, econômico, administrativo, psicossocial e de informação. Participaram 200 adolescentes primigestas (10 a 19 anos atendidas em uma unidade básica de saúde do município de Indaiatuba (SP, em 2003. Um questionário com perguntas abertas e fechadas referentes ao acesso ao último serviço de saúde utilizado, anterior à gestação, foi aplicado às participantes no momento de sua primeira consulta de pré-natal. Os dados foram analisados por meio do teste de qui-quadrado de Pearson ou exato de Fisher e por regressão logística múltipla, considerando as cinco dimensões de acesso. RESULTADOS: Mais da metade (63,7% das adolescentes utilizou algum serviço de saúde para consulta ginecológica. Entre as que nunca consultaram um ginecologista, as justificativas dadas foram falta de informação (43,8% ou sentimento de medo ou vergonha (37,0%. A principal dificuldade de acesso ao serviço esteve relacionada a barreiras psicossociais, identificadas por 77,0% das adolescentes. CONCLUSÕES: Entre as barreiras de acesso ao serviço de saúde, foram significativas apenas as psicossociais. São necessárias novas estratégias para facilitar o acesso ao serviço de saúde às adolescentes, incluindo ações que diminuam as barreiras de gênero e que se considerem suas características sociodemográficas e o vínculo com seus parceiros.OBJETIVO: Analizar los factores determinantes del acceso de adolescentes gestantes a los servicios de atención primaria a la salud, anterior a la ocurrencia de la gestación. MÉTODOS: Se efectuó estudio transversal basado en referencial teórico. El acceso a servicios fue analizado en cinco dimensiones: geográfico, econ

  2. Risco nutricional entre gestantes adolescentes Riesgo nutricional entre gestantes adolescentes Nutritional risks among pregnant teenagers

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    Glayriann Oliveira Belarmino

    2009-01-01

    Full Text Available OBJETIVOS: Identificar o acometimento de risco nutricional em gestantes adolescentes; averiguar hábitos alimentares; e verificar percepções destes quanto à importância de nutrição adequada na gravidez. MÉTODOS: Estudo de campo realizado no Centro de Desenvolvimento Familiar, em Fortaleza-CE, com 40 gestantes adolescentes. A avaliação nutricional foi efetuada com o auxílio do "Gráfico de acompanhamento nutricional da gestante" e os hábitos alimentares foram conferidos pela "Técnica de alimentação diária habitual". RESULTADOS: Vinte (50% adolescentes apresentaram peso adequado, 11(27,5% baixo peso e 9 (22,5% sobrepeso. Prevaleceram massas, carnes, gorduras, doces e baixo consumo de frutas e verduras; 33 (82,5% tinham a percepção de que a alimentação deve ser "diferente" na gravidez e 28 (70% afirmaram ter feito mudanças nos hábitos alimentares no pré-natal. CONCLUSÃO: O acometimento de risco nutricional entre adolescentes gestantes se revelou em situações de sobrepeso, baixo peso, dietas pouco diversificadas e desinformação.OBJETIVOS: Identificar el riesgo nutricional en gestantes adolescentes; averiguar hábitos alimenticios; y verificar percepciones de éstos en cuanto a la importancia de una nutrición adecuada en el embarazo. MÉTODO: Se trata de un estudio de campo realizado en el Centro de Desarrollo Familiar, en Fortaleza-CE, con 40 gestantes adolescentes. La evaluación nutricional se llevó a cabo con el auxilio del "Gráfico de acompañamiento nutricional de la gestante" y los hábitos alimenticios fueron conferidos por la "Técnica de alimentación diaria habitual". RESULTADOS: Veinte (50% adolescentes presentaron peso adecuado, 11(27,5% bajo peso y 9 (22,5% sobre peso. Prevalecieron pastas, carnes, grasas, dulces y bajo consumo de frutas y verduras; 33 (82,5% tenían la percepción de que la alimentación debe ser "diferente" durante el embarazo y 28 (70% afirmaron haber realizado cambios en los h

  3. El proceso salud-enfermedad-atención bucal de la gestante: una visión de las mujeres con base en la determinación social de la salud

    OpenAIRE

    Concha Sánchez, Sonia Constanza

    2014-01-01

    Resumen Antecedentes. La atención en salud durante el embarazo y el acceso a la atención odontológica de las gestantes en Bogotá registra profundas inequidades. Las patologías orales y las complicaciones que representan para el binomio madre-niño incentivan la necesidad de identificar el proceso salud-enfermedad-atención bucal de las gestantes sustentadas en los postulados de la determinación social de Breilh y los planteamientos de Menéndez. Objetivos. Caracterizar el proceso salud-enfermeda...

  4. Estado nutricional y ganancia de peso en gestantes peruanas, 2009-2010

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    Carolina Tarqui-Mamani

    2014-04-01

    Full Text Available Introducción: El estado nutricional materno pregestacional y la ganancia de peso durante el embarazo influyen en las condiciones maternas y perinatales e incrementan el riesgo de peso bajo al nacer, parto prematuro y la mortalidad materna perinatal. Objetivos: Describir el estado nutricional y la ganancia de peso de las gestantes que residen en los hogares peruanos. Diseño: Estudio observacional y transversal. Lugar: Instituto Nacional de Salud, Lima, Perú. Participantes: Gestantes que residen en los hogares peruanos. Intervenciones: La muestra fue probabilística, estratificada, multietápica e independiente en cada departamento del Perú, durante los años 2009 y 2010. De la muestra de 22 640 viviendas se incluyó 552 gestantes que aceptaron participar y se excluyó a las gestantes con discapacidad física que impidiera realizar la antropometría. Las mediciones antropométricas se hicieron según metodología internacional, el estado nutricional se obtuvo mediante el IMC pregestacional y la ganancia de peso se calculó según el Instituto de Medicina de los EE UU. Principales medidas de resultados: Estado nutricional y ganancia de peso de la gestante. Resultados: Se encontró que 1,4% de las gestantes iniciaron el embarazo con peso bajo, 34,9% con peso normal, 47% con sobrepeso y 16,8% con obesidad. Durante el embarazo, 59,1% de las gestantes tuvieron ganancia de peso insuficiente, 20% adecuada y 20,9% excesiva; independiente al IMC pregestacional. La mayoría de las gestantes con sobrepeso y obesidad vivían en la zona urbana y no fueron pobres. Conclusiones: Más de la mitad de las gestantes que residen en los hogares peruanos iniciaron el embarazo con exceso de peso (sobrepeso u obesidad y la mayoría de las gestantes tuvo insuficiente ganancia de peso durante el embarazo.

  5. Pregnancy Complications: Preeclampsia

    Science.gov (United States)

    ... online community Home > Complications & Loss > Pregnancy complications > Preeclampsia Preeclampsia E-mail to a friend Please fill in ... even if you’re feeling fine. What is preeclampsia? Preeclampsia is a serious blood pressure condition that ...

  6. Evaluación de una intervención mediante sofrología para disminuir la ansiedad en las gestantes con un feto con retraso de crecimiento

    OpenAIRE

    Arranz Betegón, Ángela; Montenegro Nadal, Gala; García Moliner, Marta; Roldán, A. (Aurora); Camacho Sáez, Alba; García, Milagros; Goberna Tricas, Josefina; Botet Mussons, Francisco; Gratacós Solsona, Eduard

    2017-01-01

    Objetivo: comparar el grado de ansiedad de un grupo de mujeres con un feto con retraso de crecimiento intrauterino (RCIU) visitadas exclusivamente por especialistas en medicina maternofetal en relación a otras mujeres que, además, también fueron visitadas por una matrona formada en técnicas de relajación y detectar los sentimientos prevalentes cuando se informa del diagnóstico. Material y método: estudio multimétodo: cuantitativo (diseño cuasi-experimental) y cualitativo (fenomenológico). Las...

  7. PREECLAMPSIA: NUEVAS ETIOLOGÍAS

    OpenAIRE

    Chávez Dulce, Gerardo Rafael; Tejada Córdoba, Ángela Patricia; Suárez Ayala, Diana Vanessa; Gómez Cabrera, Fleider Leovani; Cabrera Fierro, Juan Sebastián; Figueroa, Claudia

    2010-01-01

    La preeclampsia afecta entre el 5 y 7% de todas las mujeres embarazadas y sigue siendo una causa importante de mortalidad y morbilidad maternal y perinatal, es particularmente devastadora en los países en desarrollo. La etiología de la preeclampsia es desconocida. En la actualidad, cuatro hipótesis son objeto de investigación exhaustiva: (1) Disfunción de la perfusión placentaria con aumento de factores angiogénicos y bioquímicos, (2) Alteraciones metabólicas relacionadas con el incremento de...

  8. Genetics Home Reference: preeclampsia

    Science.gov (United States)

    ... Share: Email Facebook Twitter Home Health Conditions Preeclampsia Preeclampsia Printable PDF Open All Close All Enable Javascript to view the expand/collapse boxes. Description Preeclampsia is a complication of pregnancy in which affected ...

  9. Experiências e expressões de gestantes na interação com o sistema de saúde: um enfoque fotoetnográfico Experiencias y expresiones de gestantes en su interacción con el sistema de salud: un enfoque fotoetnográfico Pregnant women's experiences and expressions related to the interaction with the health system: a photoethnographic approach

    Directory of Open Access Journals (Sweden)

    Marta Maria Melleiro

    2004-06-01

    Full Text Available Estudo conduzido com o objetivo compreender a experiência da mulher, no seu contato com o sistema de saúde, por ocasião do parto. Adotou-se como referencial teórico-metodológico a Antropologia Cultural e a Etnografia. A coleta de dados foi realizada por meio da observação participante, do recurso fotográfico e da entrevista. As fotografias foram realizadas por gestantes, cujo pré-natal foi realizado nas Unidades Básicas de Saúde da área de abrangência do hospital-escola, cenário cultural desta investigação. Os dados foram apresentados na forma de narrativa, e a sua análise se deu por meio do método biográfico interpretativo. Dos dados foram extraídas oito categorias, das quais emergiram três temas culturais, por meio dos quais as colaboradoras resgatam e classificam as suas experiências, na condição de ratificar os resultados dos eventos significativos considerados positivos ou de fazer uma releitura dos eventos negativos. Elas prosseguem vislumbrando o processo de nascimento em todas as suas dimensões, utilizando o olhar fotográfico, que ora permitiu que fatos fossem registrados e absorvidos, ora evitou que suas lentes captassem aquilo que seria difícil elaborar naquele momento. Os achados deste estudo possibilitaram uma visão compreensiva do conhecimento cultural das colaboradoras com relação à sua interação com o sistema de saúde, bem como de suas expectativas no ciclo gravídico-puerperal.Este trabajo etnográfico tuvo por objetivo comprender la experiencia de la mujer en su contacto con el sistema de salud, con motivo del parto. Fueron adoptados como referencial teórico-metodológico la Antropología Cultural y la Etnografía. La recolección de datos fue por medio de la observación participante, el recurso fotográfico y la entrevista. Las fotografías fueron tomadas por las gestantes-colaboradoras con prenatal realizado en las Unidades Básicas de Salud del área de influencia del hospital escuela

  10. Sistema experto basado en lógica difusa tipo 1 para determinar el grado de riesgo de preeclampsia

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    Edna Rocio Núñez Flórez

    2014-01-01

    Full Text Available La preeclampsia es una enfermedad que pueden desarrollar las mujeres en estado de embarazo, y según el DANE es responsable del 35 % de las muertes maternas en Colombia. Ante esta situación, el objetivo de este artículo es presentar un sistema experto (SE basado en lógica difusa tipo I que permite identificar el nivel de riesgo de sufrir la enfermedad, y posibilita un diagnóstico precoz y la vigilancia estricta de la mujer gestante, aspectos fundamentales para prevenir las complicaciones asociadas a la preeclampsia. Para llevar a cabo la investigación se realizó la revisión bibliográfica para conocer los factores de riesgo que generan la enfermedad; con apoyo de un médico se establecieron los factores que se deben tener en cuenta (variables de entrada y la base de reglas, los cuales son los componentes principales del SE. Posteriormente se realiza la implementación del software con las herramientas MySql como base de datos y Java como lenguaje de programación. Para la validación de tomaron 30 historias clínicas suministradas por la Secretaría de Salud Departamental del Caquetá. El resultado del SE arrojó un 94.17 % de efectividad con un margen de error del 5.83 %, comparados con los resultados proporcionados por el especialista que analizó las historias clínicas.

  11. Caracterización de gestantes con asma bronquial en el barrio "José Félix Ribas" del municipio venezolano de Sucre Characterization of pregnant women with bronchial asthma in "José Félix Ribas" district of the Venezuelan municipality of Sucre

    Directory of Open Access Journals (Sweden)

    Bartolo Maldonado de los Reyes

    2012-08-01

    Full Text Available Se realizó un estudio descriptivo, transversal y prospectivo de 120 gestantes con asma bronquial en el barrio "José Félix Ribas" del municipio venezolano de Sucre, desde enero hasta diciembre de 2010, con vistas a caracterizarles desde el punto de vista clinicoepidemiológico. Para la recolección de la información se utilizó una planilla de datos y un cuestionario que fue procesado con la versión 6.0 del programa Epi Info. En la casuística primaron las adolescentes (56,6 %, de las cuales, 55,8 % tuvieron contacto de forma activa o pasiva con el humo del cigarrillo y 68,3 % presentaron asma bronquial grado I; asimismo, predominaron los factores desencadenantes (100,0 %, seguidos de los causales (95,8 %, de manera que las características clinicoepidemiológicas de estas embarazadas hacen que el asma bronquial sea un problema de salud para este grupo poblacional.A descriptive, cross-sectional and prospective study was carried out in 120 pregnant women with bronchial asthma in "José Félix Ribas" district of the Venezuelan municipality of Sucre, from January to December 2010, to characterize them clinically and epidemiologically. For gathering information a data sheet and a questionnaire that was processed with version 6.0 of Epi Info program were used. Adolescents (56.6 % prevailed in the case material, of them 55.8 % had active or passive contact with the cigarette smoke, and 68.3 % presented with grade I of bronchial asthma. Also, trigger factors prevailed (100.0 %, followed by causal factors (95.8 %, so that clinical and epidemiological characteristics of these pregnant women make a health problem of bronchial asthma in this population group.

  12. Conocimientos y prácticas alimentarias en gestantes asistentes al programa de control prenatal, en municipios del departamento de Antioquia, Colombia. 2010

    OpenAIRE

    Torres Trujillo, Luz Estella; Ángel Jiménez, Gloria; Calderon Higuita, Gloria; Fabra Arrieta, Julio Cesar; López Galeano, Sandra Catalina; Franco Restrepo, María Alexandra; Bedoya Ávalos, Nataly; Ramírez Puerta, Deisy

    2012-01-01

    Antecedentes: una dieta saludable, el reconocimiento de signos de alarma, la asistencia al control prenatal y el consumo de los suplementos recomendados son fundamentales para culminar con éxito la gestación. Objetivo: identificar conocimientos, prácticas alimentarias y consumo de suplementos en gestantes. Materiales y métodos: estudio descriptivo en 295 gestantes beneficiarias de un programa complementación alimentaria, en 12 municipios antioqueños. Resultados: más de 60% de las gestantes de...

  13. Preeclampsia - self-care

    Science.gov (United States)

    ... this page: //medlineplus.gov/ency/patientinstructions/000606.htm Preeclampsia - self-care To use the sharing features on ... as you get used to it. Risks of Preeclampsia There are risks to both you and your ...

  14. Conduta anestésica em cesariana em gestante com aneurisma intracraniano não roto Conducta anestésica en cesárea en embarazada con aneurisma cerebral íntegro Anesthetic conduct in cesarean section in a parturient with unruptured intracranial aneurysm

    Directory of Open Access Journals (Sweden)

    Luciana de Souza Cota Carvalho

    2009-12-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: O manuseio anestésico para cesariana programada em gestante com aneurisma intracraniano não roto é particularmente interessante, pois apresenta diversas particularidades relacionadas às alterações fisiológicas da gestação acrescida dos riscos de ruptura do aneurisma durante o procedimento anestésico. A literatura é escassa nesse assunto, sendo assim importante a divulgação dos casos. RELATO DO CASO: Gestante de termo, 31 anos, com aneurisma intracraniano não roto submetida à cesariana programada sob anestesia peridural simples. O procedimento evoluiu sem intercorrências para mãe e filho. CONCLUSÕES: Recomendações baseadas em evidências para anestesia obstétrica em pacientes portadoras de aneurisma intracraniano não roto não existem. Não há dados experimentais ou clínicos que confirmem ou refutem anestesia geral ou regional nesse contexto. Dessa forma, a decisão de qual técnica utilizar deve ser feita com bases individuais, ponderando os riscos e benefícios de cada procedimento e a experiência do profissional que irá conduzi-la.JUSTIFICATIVA Y OBJETIVOS: El manejo anestésico para la cesárea programada en embarazada con aneurisma cerebral íntegro es particularmente interesante, porque presenta diversas particularidades relacionadas con las alteraciones fisiológicas del embarazo y por añadidura, con los riesgos de ruptura del aneurisma durante el procedimiento anestésico. La literatura es parca en ese asunto, siendo muy importante la divulgación de los casos. RELATO DEL CASO: Embarazada de término, 31 años, con aneurisma cerebral no roto y sometida a la cesárea programada bajo anestesia epidural simple. El procedimiento evolucionó sin intercurrencias para la madre y el hijo. CONCLUSIONES: No existen recomendaciones basadas en evidencias, para la anestesia obstétrica en pacientes portadoras de aneurisma cerebral no roto. No hay datos experimentales o clínicos que confirmen o que

  15. FACTORES ASOCIADOS AL DESARROLLO DE PREECLAMPSIA EN UN HOSPITAL DE PIURA, PERÚ

    OpenAIRE

    Yamalí Benites-Cóndor; Susy Bazán-Ruiz; Danai Valladares-Garrido

    2011-01-01

    Introducción: La Organización Mundial de la Salud indica que diariamente fallecen alrededor de 800 mujeres por causas relacionadas al embarazo y parto, dentro de las cuales la preeclampsia ocupa el tercer lugar. Objetivo: identificar los factores asociados a preeclampsia en gestantes que fueron hospitalizadas en el Hospital de Apoyo II "Santa Rosa" de la ciudad de Piura durante el periodo junio 2010 - mayo 2011. Métodos: Se realizó un estudio descriptivo retrospectivo de casos y controles, e...

  16. Molecular Mechanisms of Preeclampsia

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    N. Vitoratos

    2012-01-01

    Full Text Available Preeclampsia is one of the leading causes of maternal morbidity/mortality. The pathogenesis of preeclampsia is still under investigation. The aim of this paper is to present the molecular mechanisms implicating in the pathway leading to preeclampsia.

  17. Gestantes HIV positivas e sua não-adesão à profilaxia no pré-natal Mujeres embarazadas con HIV positivo y su non adhesión a la profilaxia en el prenatal HIV positive pregnant women who do not follow the prenatal prophylaxis

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    Petrolina Libana Cechim

    2007-10-01

    Full Text Available Este é um estudo exploratório descritivo com abordagem qualitativa. Investigamos a não-adesão de gestantes portadoras do vírus HIV/AIDS ao tratamento preconizado pelo Ministério da Saúde no período pré-natal. Os sujeitos desta pesquisa foram sete mulheres soropositivos, que, durante a gestação, não aderiram ao tratamento profilático recomendado. Os dados foram coletados por uma entrevista semi-estruturada. Para a análise dos dados, elaboramos categorias com base nas falas destes sujeitos. Com os resultados, observamos que existe a vulnerabilidade da mulher em realizar a negociação do sexo seguro com o seu parceiro e que associado às baixas condições socio-econômicas, desemprego e falta de afeto, faz com que as mulheres se tornem vítimas do HIV/AIDS.Este es un estudio exploratorio descriptivo con abordaje cualitativo. Se buscó investigar a la no adhesión de las gestantes portadoras del vírus HIV/SIDA al tratamiento preconizado por el Ministério de la Salud en el periodo prenatal. Los sujetos de esta encuesta fueron siete mujeres seropositivas, que durante la gestación, no se adhirieron al tratamiento profiláctico recomendado por el Ministerio de la Salud. Los datos fueron colectados por las autoras del estudio, a través de una entrevista semiestructurada. Para el análisis de los datos, elaboramos categorías desde lo que expresaron estos sujetos. Con los resultados observamos que existe la vulnerabilidad de la mujer en realizar negociación del sexo seguro con su compañero y que asociado a las bajas condiciones socioeconómicas, desempleo y falta de afecto, hace con que las mujeres se conviertan en víctimas del HIV/SIDA.This is an exploratory study based on a qualitative approach. The objective was to investigate why HIV positive pregnant women do not follow the treatment which is recommended by the Health Ministry during the prenatal period. The individuals participating of this investigation were seven HIV

  18. Significado de las prácticas de cuidado cultural en gestantes adolescentes de Barranquilla (Colombia

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    Maribel Muñoz-Henríquez

    2016-01-01

    Full Text Available Objetivo:describir el significado de las prácticas de cuidado cultural en un grupo de gestantes adolescentes asistentes al controlprenatal del Hospital Niño Jesús de Barranquilla, Colombia, y de su hijo por nacer.Método:estudio cualitativo etnográfico, en el que seaplicó el concepto propuesto por Leininger. Las participantes fueron: 10 gestantes adolescentes entre 15 y 19 años, y 12 enfermeras conexperiencia en el área. Las primeras como informantes clave, y las segundas como informantes generales.Resultados:el significadode las prácticas de cuidado cultural, para las gestantes adolescentes, se clasifica en tres temas: 1 prácticas de cuidado transmitidas degeneración en generación, predominando la línea femenina; 2 la confianza en Dios y el apoyo de la familia como una forma de cuidarse;3 dar a luz un hijo sano.Conclusiones:las prácticas de cuidado de las gestantes adolecentes están enraizadas en sus creencias, mitosy valores culturales heredados de generación en generación, lo que muestra patrones de cuidado cultural. Este aspecto debe ser identifi-cado por enfermería para ofrecer cuidados que sean culturalmente congruentes con esta población.

  19. Comparación de las prácticas de cuidado en dos grupos de gestantes en la ciudad de Sincelejo

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    LUZ MARINA GARCÍA GARCÍA

    2008-07-01

    Full Text Available Para comparar las prácticas de cuidado que realizan consigo mismas y con su hijo por nacer un grupo de gestantes adolescentes y otro grupo de gestantes adultas que asisten a control prenatal en Sincelejo, durante los meses de julio y septiembre de 2006, se desarrolló un estudio descriptivo, cuantitativo y transversal, con una muestra de 97 gestantes adolescentes entre 15 y 19 años y de 153 gestantes adultas entre 20 y 45 años, sin patologías asociadas, a quienes se les aplicó un instrumento sobre prácticas de cuidado, validado por la Universidad Nacional de Colombia, sede Bogotá. Estas prácticas se clasificaron en buenas, regulares y malas, en los dos grupos, para establecer la comparación cuantitativa de las mismas. Los principales resultados fueron: diferencias estadísticamente significativas en las dimensiones de estimulación prenatal, higiene y cuidados personales, alimentación y sustancias no beneficiosas; en estas cuatro dimensiones el resultado de buenas prácticas fue más favorable para las gestantes adultas; no se encontró diferencia significativa en las dimensiones de ejercicio y descanso, y sistemas de apoyo. La mayoría de las gestantes adultas (81,7% realizaban actividades domésticas que les producían cansancio; 23,53% no desarrollaban actividades recreativas; 25,77% de las gestantes adolescentes y 41,18% de las gestantes adultas consumían lácteos. 19,59% de las gestantes adolescentes y 6,54% de las adultas no evitaban el consumo de licor y 4,12% de las gestantes adolescentesy0,65% de lasgestantes adultas habían consumido sustancias psicoactivas. Tanto adolescentes (68,04% como adultas (52,29% realizaban prácticas de estimulación prenatal catalogadas como regulares. Solo 31,37% de las gestantes adultas y 21,65% de las gestantes adolescentes tenían prácticas adecuadas de estimulación prenatal.

  20. Programa de atención integral a la adolescente gestante

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    Ana Cecilia Rico-Coronel

    2013-06-01

    Full Text Available El embarazo adolescente es uno de los principales problemas en la sociedad, generando alto impacto psicológico, económico y social en la joven y la familia. Su incidencia va en aumento a pesar de las campañas para disminuir su prevalencia. La captación temprana de las gestantes al control prenatalpromueve la prevención, la identificación y el control oportuno de los factores de riesgo biológico, psicológico, social y ambiental que inciden en la gestación. En este sentido se realizó un trabajo de extensión, con 95 adolescentes gestantes, durante un periodo de 11 meses, en el cual se trabajó con la adolescente, su pareja, y su familia.

  1. Retardo del crecimiento intrauterino asociado con el consumo de pasta básica de cocaína por mujeres gestantes de Bogotá, D.C., Colombia

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    Oscar Ramírez

    2000-12-01

    Full Text Available El objetivo de este estudio fue identificar una posible asociación entre el consumo de pasta ásica de cocaína o 'basuco' entre mujeres embarazadas y el crecimiento intrauterino de sus productos vivos en dos hospitales de tercer nivel en Bogotá, Colombia. Con un diseño de cohorte retrospectiva, se encuestaron 1.878 mujeres en el puerperio mediato para indagar, entre otras variables, la historia sobre el consumo de drogas ilicitas. Tanto a las madres como a sus recién nacidos se les realizaron mediciones antropométricas estandarizadas. Se comparó la prevalencia de bajo peso al nacer (BPN, parto prematuro (PP y retardo del crecimiento intrauterino (RCIU con la historia de consumo de drogas ilicitas durante el embarazo por medio de modelos de regresión lineal múltiple y regresión logística múltiple, para ajustar el efecto de posibles confusores como edad materna, estado nutricional y patologias maternas, nivel socioeconómico, escolaridad y tabaquismo, entre otros. Los resultados mostraron que una de cada 189 mujeres consumió sustancias ilegales durante el embarazo, comúnmente Cannabis safiva o pasta básica de cocaina. Las consumidoras de ostos productos tipicamente tenían menor escolaridad, eran de nivel socioeconomico más bajo. eran más delgadas, con una historia de control prenatal inadecuado, primigestantes o multigestantes y, con frecuencia, también fumaban tabaco y bebían alcohol. Se halló una asociación entre el consumo de las sustancias ilegales con RCIU (cociente de suertes de prevalencias de 5.24, IC95%: 1,3-21.0, y un déficit de 0.7 desvios estándares del peso para la edad gestacional (p=0.03. Además, se encontró un cociente de suertes ajustado de 7,78 con IC95%: 1,O-62, entre el consumo de pasta básica de cocaina y RCIU. Aunque es probable que a través de entrevistas se subestime la prevalencia de consumo de drogas y a pesar del limitado poder del estudio, éste fue capaz de identificar un efecto importante

  2. Relación de los parámetros del cribado de aneuploidías del primer trimestre con las alteraciones del metabolismo de los hidratos de carbono en la gestante.

    OpenAIRE

    Muñoz Ledesma, Ana María

    2013-01-01

    [ES] La diabetes mellitus (DM) es la alteración metabólica que más frecuentemente asociada con el embarazo. Aproximadamente un 1% de las mujeres embarazadas presentan DM antes de la gestación y entre un 1-12%1 dependiendo de la estrategia diagnóstica empleada, presentan DM en el transcurso del embarazo. La diabetes gestacional (DG) es una intolerancia de los hidratos de carbono o disminución de su tolerancia, que aparece o se diagnostica durante la gestación independientemente ...

  3. Adenosine and preeclampsia.

    Science.gov (United States)

    Salsoso, Rocío; Farías, Marcelo; Gutiérrez, Jaime; Pardo, Fabián; Chiarello, Delia I; Toledo, Fernando; Leiva, Andrea; Mate, Alfonso; Vázquez, Carmen M; Sobrevia, Luis

    2017-06-01

    Adenosine is an endogenous nucleoside with pleiotropic effects in different physiological processes including circulation, renal blood flow, immune function, or glucose homeostasis. Changes in adenosine membrane transporters, adenosine receptors, and corresponding intracellular signalling network associate with development of pathologies of pregnancy, including preeclampsia. Preeclampsia is a cause of maternal and perinatal morbidity and mortality affecting 3-5% of pregnancies. Since the proposed mechanisms of preeclampsia development include adenosine-dependent biological effects, adenosine membrane transporters and receptors, and the associated signalling mechanisms might play a role in the pathophysiology of preeclampsia. Preeclampsia associates with increased adenosine concentration in the maternal blood and placental tissue, likely due to local hypoxia and ischemia (although not directly demonstrated), microthrombosis, increased catecholamine release, and platelet activation. In addition, abnormal expression and function of equilibrative nucleoside transporters is described in foetoplacental tissues from preeclampsia; however, the role of adenosine receptors in the aetiology of this disease is not well understood. Adenosine receptors activation may be related to abnormal trophoblast invasion, angiogenesis, and ischemia/reperfusion mechanisms in the placenta from preeclampsia. These mechanisms may explain only a low fraction of the associated abnormal transformation of spiral arteries in preeclampsia, triggering cellular stress and inflammatory mediators release from the placenta to the maternal circulation. Although increased adenosine concentration in preeclampsia may be a compensatory or adaptive mechanism favouring placental angiogenesis, a poor angiogenic state is found in preeclampsia. Thus, preeclampsia-associated complications might affect the cell response to adenosine due to altered expression and activity of adenosine receptors, membrane transporters

  4. Percepciones de las gestantes en torno al cuidado humanizado por enfermería

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    Ivett Adriana Herrera-Zuleta

    2016-12-01

    Full Text Available Objetivo: determinar las percepciones de comportamiento del cuidado humanizado de enfermería en un grupo de gestantes del servicio de ginecobstetricia de un hospital de alta complejidad del sur-occidente de Colombia, mediante la aplicación de un instrumento, percepciones del cuidado humanizado en enfermería en su primera versión validada por la Universidad Nacional de Colombia. Materiales y Métodos: investigación cuantitativa descriptiva, de corte transversal. La muestra fue de 97 gestantes obtenidos por muestreo no probabilístico por conveniencia, mediante la fórmula para tamaño óptimo cuando la población es conocida. Se tuvo en cuenta las variables sociodemográficas y la percepción de los comportamientos de cuidado humanizado de enfermería. Resultados: el 59 % de las gestantes percibieron el comportamiento del cuidado humanizado como excelente; las categorías con mayor porcentaje fueron características de la enfermera, priorizar al ser de cuidado y proactividad, mientras que las categorías con menor valor fueron empatía, disponibilidad para la atención y dar apoyo emocional. Conclusión: el cuidado humanizado de enfermería, en todas las categorías, fue calificado como bueno y excelente, lo que demuestra una adecuada percepción por parte de las gestantes; sin embargo, es importante fortalecer aspectos relacionados con la empatía y la actitud.

  5. Concepciones del embarazo en adolescentes gestantes de la ciudad de Bucaramanga

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    Beatriz Andrea del Pilar Niño

    2017-09-01

    Full Text Available Introducción: El embarazo adolescente es una problemática que tiene consecuencias en la vida de las adolescentes y sus familias. Conocer las concepciones y representaciones que tienen las adolescentes gestantes es una herramienta fundamental para fortalecer la toma de decisiones y las redes de apoyo social. Objetivo: Identificar las concepciones sobre el embarazo, las características sociales, económicas y de redes de apoyo en un grupo de adolescentes gestantes de Bucaramanga. Materiales y Métodos: Se realizó un estudio cualitativo (estudio de caso mediante las técnicas de grupo focal, observación participante y elaboración de diario de campo. Se incluyeron 15 participantes de las 100 adolescentes beneficiadas por el Programa Plan Padrino de la Secretaría de Salud y Ambiente de Bucaramanga durante el año 2014. Resultados: La mayoría de las participantes refirieron que, aunque el embarazo fue no deseado lo han aceptado y asumido con grandes cambios en sus vidas, especialmente la relación con sus amigos y con su familia. Identificaron como red de apoyo fundamental la familia. Discusión: Las concepciones sobre embarazo en las adolescentes coinciden con los estudios reportados en Colombia en el sentido que lo asumieron con responsabilidad, pero les representó un doble reto en especial para continuar con sus estudios. Conclusiones: Fortalecer la red de apoyo de las adolescentes en especial la relacionada con procesos educativos y de familia. Cómo citar este artículo: Niño BAP, Ortíz SP, Solano S, Amaya CM, Serrano L. Concepciones del embarazo en adolescentes gestantes de la ciudad de Bucaramanga. Rev Cuid. 2017; 8(3: 1875-86. http://dx.doi.org/10.15649/cuidarte.v8i3.448

  6. Disertación endocrina de la preeclampsia y propuesta de una hipótesis Endocrine dissertation on preeclampsia and proposal of a hypothesis

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    Bernardo Agudelo Jaramillo

    1992-01-01

    Full Text Available

    Se propone que la facies androgenizada en las embarazadas podría servir como elemento clínico para la búsqueda de la preeclampsia, con el fin de lograr un enfoque preventivo. El balance de las prostaglandinas vasodilatadoras y vasoconstrictoras es, en último término, responsable del control de la presión arterial en la gestante. Para ello se debe lograr un adecuado equilibrio en la producción de hormonas gestacionales; de ellas parece ser fundamental la dihidroprogesterona que se obtiene a través de la acción de la enzima 5-alfa reductasa. En el metabolismo de los andrógenos esta enzima cumple un papel único al transformar los andrógenos circulantes en la hormona trófica, la dihidrotestosterona. La hipótesis propone que la utilización androgénica de la enzima 5-alfa reductasa durante la gestación alteraría la producción de dihidroprogesterona con lo cual crearía un desequilibrio entre las diferentes hormonas y, finalmente, entre las prostaglandinas.

    The hypothesis that an androgenized facies In a pregnant woman could serve as a clinical clue for the search of preeclampsia, making It possible to apply a preventive approach is proposed. The balance between dilator and constrictor prostaglandins controls blood pressure during pregnancy; to keep such a balance an adequate equilibrium in the production of hormones, particularly dihydroprogesterone (DHP, is necessary. DHP is obtained through the action of 5-alpha reductase, which in androgen metabolism has the unique role of transforming circulating androgens into the trophic hormone dihydrotestosterone. The hypothesis proposes that androgenic utilization of 5- alpha reductase during pregnancy could alter the production of DHP I generating a lack of equilibrium among the various hormones, prostaglandins included.

  7. Vivências de gestantes e puérperas com o diagnóstico do HIV Experiencias de mujeres embarazadas y en el postparto con diagnóstico de HIV Experiences of pregnant and post-partum women with HIV

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    Maria Alix Leite Araújo

    2008-10-01

    Full Text Available Identificar as experiências de gestantes e puérperas portadoras do HIV com a quimioprofilaxia para prevenção da transmissão vertical. Estudo de abordagem qualitativa desenvolvido nos meses de março e abril de 2006 em uma maternidade de referência de Fortaleza-Ceará. Os sujeitos foram gestantes e puérperas HIV positivas em acompanhamento pré-natal e no alojamento conjunto. A coleta de dados deu-se através de entrevista e a análise em três categorias: a revelação do diagnóstico aos familiares, o aconselhamento e a vivência das recomendações para a profilaxia da transmissão vertical. Constatou-se que essas mulheres enfrentaram situações de conflitos e sentimentos negativos diante da vida e a importância do acompanhamento emocional por equipe multiprofissional capacitada, atenta as demandas subjetivas.Identificar las experiencias de las embarazadas y madres recientes portadoras de HIV con la quimioprofilaxia para la prevención de la transmisión vertical. Estudio de abordaje cualitativo desarrollado entre los meses de marzo y abril de año 2006, en maternidad importante de Fortaleza/CE. Las personas fueron embarazadas y madres recientes HIV positivas en acompañamiento prenatal y en alojamiento conjunto. La colecta de datos ocurrió a través de entrevista y análisis en tres categorías: La revelación del diagnóstico a los familiares, el consejo y la vida de las recomendaciones para la profilaxia de las transmisión vertical. Constatase que las mujeres enfrentan situaciones de conflictos y sentimientos negativos delante de la vida y que el acompañamiento individual por una equipo de múltiplos profesionales capacitadas diminuye mucho su estado emocional.Detect the experiences of pregnants and mothers that bear the HIV viruses using quimioprophylaxlis to prevent the upright transmission. A research of qualitative approach developed between march and april of 2006 on main mother-hoods in Fortaleza - Ceará. The persons were

  8. Caracterización de los factores de riesgo en gestantes con hipertensión gestacional y crónica en un área de salud Characterization of the risk factors present in pregnant with chronic and gestational hypertension in a health area

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    Yuselis Torres Sánchez

    2009-09-01

    Full Text Available INTRODUCCIÓN: los trastornos hipertensivos de la gestación constituyen una de las complicaciones más frecuentes que causan morbimortalidad materno-fetal, por lo que la reducción de su prevalencia e incidencia es una prioridad. Para enfrentar este reto se debe tener un enfoque médico integral en la atención preconcepcional y concepcional a la mujer, que condicione una mejor calidad de vida. OBJETIVO: describir la tendencia que han tenido estos trastornos en los últimos 4 años (2004-2007, y los factores de riesgo que con más frecuencia se presentaron. MÉTODOS: se diseñó un estudio observacional analítico transversal utilizando un universo de estudio de 25 gestantes con trastornos hipertensivos de la gestación del área de salud "Dr. Antonio Pulido Humarán". RESULTADOS: la hipertensión gestacional y la hipertensión arterial crónica tuvieron una tendencia ascendente en su prevalencia en el período 2004-2007. La obesidad, el tabaquismo, las inadecuadas condiciones socioeconómicas, la no suplementación de folatos, entre otras, constituyeron los factores de riesgo más frecuentes.INTRODUCTION: pregnancy hypertensive disorders are one of the more frequent complications causing morbidity and mortality in mother-fetus, where decrease of its prevalence and incidence is a priority. To confront this challenge we must to have a integral medical approach on woman pre-conception and conception care to achieve a better quality of life.] OBJECTIVE: to describe trend of these disorders during past 4 years (2004-2007, and the more frequent risk factors. METHODS: authors designed a cross-sectional, analytical and descriptive study using a cohort of 25 pregnant with hypertensive disorders related to this condition from "Dr. Antonio Pulido Humarán" health area. RESULTS: pregnancy hypertension and chronic high blood pressure had a rising trend in its prevalence during 2004-2007. Obesity, smoking, and the inappropriate socioeconomic conditions, the

  9. Percepción sobre el control prenatal de las gestantes adolescentes en la E.S.E San Cristóbal, Bogotá 2012

    OpenAIRE

    Mayorga Palacios, Andrea del Pilar

    2012-01-01

    Objetivo: Explorar la percepción que tienen las gestantes adolescentes con relación al control prenatal, en el Hospital San Cristóbal de Bogotá. Diseño metodológico: Estudio cualitativo, exploratorio, con enfoque hermenéutico, realizado mediante la técnica de análisis de contenido a las entrevistas semi-estructuradas de 12 gestantes adolescentes que asisten al control prenatal en la Empresa Social del Estado San Cristóbal de la ciudad de Bogotá, 2012. Resultados: Del análisis emergieron 5 c...

  10. Náuseas y vómitos en gestantes: ¿Los psicólogos podemos predecir su aparición?

    OpenAIRE

    Roa Meggo, Ysis

    2008-01-01

    Las náuseas y los vómitos son síntomas comunes del embarazo. Sin embargo, la revisión de la literatura refiere investigaciones en las que se lograron delimitar variables que podrían contribuir con el trazado de un perfil psicológico de la gestante con náuseas y vómitos. Por tanto el objetivo de este trabajo, fue analizar si los datos existentes sobre el perfil psicológico de la mujer gestante, continúan vigentes en sus contenidos y si son susceptibles de aplicación en la actualidad en una mue...

  11. Identificación y caracterización sindromológica desde la medicina tradicional china (MTC) del cuadro clínico de mujeres ingresadas al Hospital Gíneco-Obstétrico Isidro Ayora (HGOIA) y al Hospital Carlos Andrade Marín (HCAM) con diagnóstico biomédico de preeclampsia CIE10 O14

    OpenAIRE

    Mena Echeverría, Fabián Eduardo

    2017-01-01

    Se estudiaron 30 casos de mujeres ingresadas con diagnóstico de preeclampsia en los hospitales Gíneco Obstétrico Isidro Ayora (HGOIA) y Carlos Andrade Marín (HCAM) de Quito, entre los meses de junio y septiembre de 2016, aplicando la historia clínica de medicina tradicional china ACUMOX, con el fin de identificar los síndromes de la medicina tradicional china (MTC) en estas 30 mujeres. El cuadro clínico de estas mujeres corresponde a 12 síndromes diferentes, desde la óptica de la MTC, de los ...

  12. Preeclampsia and High Blood Pressure During Pregnancy

    Science.gov (United States)

    ... Gynecologists f AQ FREQUENTLY ASKED QUESTIONS FAQ034 PREGNANCY Preeclampsia and High Blood Pressure During Pregnancy • What is ... is chronic hypertension during pregnancy managed? • What is preeclampsia? • When does preeclampsia occur? • What causes preeclampsia? • What ...

  13. Molecular Mechanisms of Preeclampsia.

    Science.gov (United States)

    Hod, Tammy; Cerdeira, Ana Sofia; Karumanchi, S Ananth

    2015-08-20

    Preeclampsia is a pregnancy-specific disease characterized by new onset hypertension and proteinuria after 20 wk of gestation. It is a leading cause of maternal and fetal morbidity and mortality worldwide. Exciting discoveries in the last decade have contributed to a better understanding of the molecular basis of this disease. Epidemiological, experimental, and therapeutic studies from several laboratories have provided compelling evidence that an antiangiogenic state owing to alterations in circulating angiogenic factors leads to preeclampsia. In this review, we highlight the role of key circulating antiangiogenic factors as pathogenic biomarkers and in the development of novel therapies for preeclampsia. Copyright © 2015 Cold Spring Harbor Laboratory Press; all rights reserved.

  14. Molecular Mechanisms of Preeclampsia

    Science.gov (United States)

    Hod, Tammy; Cerdeira, Ana Sofia; Karumanchi, S. Ananth

    2015-01-01

    Preeclampsia is a pregnancy-specific disease characterized by new onset hypertension and proteinuria after 20 wk of gestation. It is a leading cause of maternal and fetal morbidity and mortality worldwide. Exciting discoveries in the last decade have contributed to a better understanding of the molecular basis of this disease. Epidemiological, experimental, and therapeutic studies from several laboratories have provided compelling evidence that an antiangiogenic state owing to alterations in circulating angiogenic factors leads to preeclampsia. In this review, we highlight the role of key circulating antiangiogenic factors as pathogenic biomarkers and in the development of novel therapies for preeclampsia. PMID:26292986

  15. Prevalencia de anemia en gestantes en un área de salud

    Directory of Open Access Journals (Sweden)

    Marianela de la C Prendes Labrada

    2000-02-01

    Full Text Available Se realizó un estudio descriptivo de corte transversal en el período comprendido entre enero y septiembre de 1998 en el área del Policlínico Santos Suárez con el objetivo de determinar la prevalencia de la anemia en gestantes, su relación con la edad, el estado nutricional materno y el peso al nacer. La muestra estuvo constituida por las 209 gestantes que se captaron en este período. Se realizó revisión de las historias clínicas obstétricas y los datos se recogieron en planilla confeccionada al efecto, se utilizó el cálculo porcentual para su procesamiento. La prevalencia de la anemia en las embarazadas estudiadas fue del 64,59 %, el 83,74 % tenían entre 20 y 35 años. Las gestantes con valoración ponderal inicial (V.P.I. peso bajo I-II-III-IV y peso adecuado desarrollaron anemia con mayor frecuencia. Predominó la hemoglobina entre 109-100 g/l en los 3 trimestres de la gestación independientemente de la V.P.I. La mayoría de las gestantes anémicas (80,74 % se trataron con tabletas prenatales solamente y aportaron recién nacidos con un peso menor de 3 000 gA descriptive cross-sectional study was conducted between January and September, 1998, in the area of the "Santos Suárez" Polyclinic in order to determine the prevalence of anemia in pregnant women, its relatioship with age, maternal nutritional state and birth weight. The sample was composed of 209 pregnant women that were caught in this period. The obstetric medical histories were reviewed and the data were collected in forms created to this end. The percentage calculstion was used for their processing. The prevalence of anemia among the studied expectants was of 64. 59 %. 83.74 % were between 20 and 35 years old. Those pregnant women with initial weighted assessment (IWA considered as low weight I-II-III-IV an adequate weight developed anemia with higher frequency. Haemoglobine from 109 to 100 g/L predominated during the 3 trimesters of pregnancy independently of I

  16. Imagem corporal de gestantes: um estudo longitudinal

    Directory of Open Access Journals (Sweden)

    Juliana Fernandes Filgueiras Meireles

    Full Text Available RESUMO Objetivos Comparar atitudes corporais, atitudes alimentares, sintomas depressivos, autoestima, ansiedade e índice de massa corporal (IMC de gestantes em diferentes momentos ao longo da gestação, bem como verificar a influência que as variáveis estudadas exercem sobre as atitudes corporais no primeiro, segundo e terceiro trimestre gestacional. Métodos Foram incluídas 17 gestantes que frequentavam o exame pré-natal na cidade de Juiz de Fora-MG, entre 22 e 41 anos de idade (média de 30,76 ± 5,65 anos, excluindo-se aquelas com dados incompletos. Como instrumentos de avaliação utilizaram-se: Body Attitudes Questionnaire, Eating Attitudes Test-26, Beck Depression Inventory, Rosenberg Self-esteem Scale, a versão curta do Brazilian State-Trait Anxiety Inventory e o questionário sociodemográfico. Ademais, foram coletados dados antropométricos e obstétricos. Foram realizadas análises estatísticas descritivas, comparativas e correlacionais. Resultados O IMC, as atitudes corporais negativas e a subescala “sentimento de gordura” aumentaram progressivamente ao longo da gestação (p 0,05. Além disso, o IMC explicou 31% da variância das atitudes direcionadas ao corpo no primeiro trimestre, enquanto as atitudes alimentares foram responsáveis por 30% e 46% das atitudes corporais no segundo e terceiro trimestre, respectivamente. Conclusões As atitudes corporais, as atitudes alimentares, os sintomas depressivos, a autoestima e a ansiedade mantiveram-se constantes ao longo da gestação. O IMC e as atitudes alimentares influenciaram a imagem corporal em gestantes. Sugere-se a criação de instrumentos específicos a fim de um melhor entendimento das preocupações relacionadas ao corpo de gestantes.

  17. Doppler flowmetry in preeclampsia.

    Science.gov (United States)

    Zahumensky, J

    2009-01-01

    The purpose of this study was to summarize the new published data on the Doppler flowmetry in preeclampsia. We summarize the new published data on the Doppler flowmetry in uteroplacental, fetoplacental and fetal circulation in preeclampsia. The present review summarized the results of clinical research on the Doppler flowmetry in the screening of risk of preclampsia, in the diagnosis of preclampsia and in the fetal risk in preclampsia (Ref. 19). Full Text (Free, PDF) www.bmj.sk.

  18. Factores de capacidad en el uso de control prenatal adecuado en gestantes de Sincelejo (Colombia

    Directory of Open Access Journals (Sweden)

    Clarybel Miranda Mellado

    2016-01-01

    Full Text Available Objetivo: Determinar los factores de capacidad relacionados con el uso adecuado de control prenatal en gestantes de Sincelejo (Colombia en 2014. Materiales y métodos: Estudio analítico de corte transversal, con una muestra de 730 gestantes, seleccionadas mediante muestreo por conglomerados. La información fue reco - lectada por medio de Encuesta Sociodemográfica y de Caracterización familiar, Escala de Apgar Familiar y Escala de Satisfacción con los Servicios Sanitarios. Para la tabulación de datos se usó Microsoft Excel V-2010, SPSSS V-17, y para el análisis, las pruebas OR y Análisis Multivariado. Resultados: El 97,7 % de las gestantes asiste al control prenatal. Sobre las razones de asistencia, 83,9 % (598 dijo que lo hacía para detectar alteraciones y 14,6 % (104 por recomendación de alguien; las 17 gestantes que no asistían al control citaron como razo - nes: porque deben hacer mucho trámite (47,1 %(8, por haber perdido la cita (23,5 %(4, porque creen no necesitar el control porque habían tenido hijos sin problemas (23,5 %(4, y porque creen que es muy temprano para iniciar el control (5,9 %(1. Acerca del uso de control prenatal se encontró que el 75,6 % (552 hace uso adecuado de este servicio. Conclusiones: Al hacer un análisis estadístico mediante razones de momios ( OR , para hallar asociación con los factores de capacidad, se encontró asociación estadísticamente significativa entre el uso adecuado de control prenatal y dos variables de capacidad: la afiliación a un régimen de salud y la satisfacción con los servicios de control prenatal.

  19. La vivencia de la pre-eclampsia: una dura travesía para la cual no se está preparada

    Directory of Open Access Journals (Sweden)

    Celmira Laza Vásquez

    2014-08-01

    Full Text Available Objetivo: Describir las experiencias vividas por las mujeres con una gestación por preeclampsia severa en el Hospital de San José de la ciudad de Bogotá, Colombia. Método: Estudio cualitativo fenomenológico. Participaron diez mujeres puérperas que presentaron preeclampsia severa y fueron atendidas en el Hospital de San José durante el año 2012. Las participantes fueron seleccionaron mediante un muestreo intencional. El tamaño de la muestra se determinó por el criterio de saturación de la información. La información se recolectó mediante de una entrevista a profundidad y los datos se analizaron mediante la propuesta de Colaizzi. Resultados: La vivencia de la enfermedad dio cuenta de tres grandes categorías. Dos de ellas, la vivencia de la mujer, y con su hijo prematuro, emergieron como travesías que narraron el duro camino recorrido por el binomio madre-hijo desde su hospitalización hasta la recuperación de los dos en el hogar y los diferentes soportes con los que contó. Estas trayectorias estuvieron marcadas por sentimientos de miedo, angustia, incertidumbre; el sufrimiento por los síntomas físicos y el sometimiento a dolorosos procedimientos médicos. La tercera categoría dio cuenta de la falta de preparación de las participantes para enfrentarse a la enfermedad y todo lo que conllevaba. Conclusiones: Es necesario el fortalecimiento de las redes de apoyo primario y el papel de Enfermería como soporte para las gestantes; así como la revisión de las condiciones de hospitalización. La preparación para el impacto emocional y las consecuencias de afrontar una preeclampsia es un aspecto que se pudiera abordar durante el control prenatal.

  20. Vivências de gestantes e puérperas com o diagnóstico do HIV Experiencias de mujeres embarazadas y en el postparto con diagnóstico de HIV Experiences of pregnant and post-partum women with HIV

    OpenAIRE

    Maria Alix Leite Araújo; Cláudia Bastos da Silveira; Caroline Bastos da Silveira; Simone Paes de Melo

    2008-01-01

    Identificar as experiências de gestantes e puérperas portadoras do HIV com a quimioprofilaxia para prevenção da transmissão vertical. Estudo de abordagem qualitativa desenvolvido nos meses de março e abril de 2006 em uma maternidade de referência de Fortaleza-Ceará. Os sujeitos foram gestantes e puérperas HIV positivas em acompanhamento pré-natal e no alojamento conjunto. A coleta de dados deu-se através de entrevista e a análise em três categorias: a revelação do diagnóstico aos familiares, ...

  1. Pre-eclampsia: Factores de riesgo. Estudio en el Hospital Nacional Cayetano Heredia.

    OpenAIRE

    Salviz Salhuana, Manuel; Cordero Muñoz, Luis; Saona Ugarte, Pedro

    1996-01-01

    Objetivo: El objetivo fue evaluar los factores de riesgo asociados a pre-eclampsia en nuestro hospital. Material y métodos: Se realizó un estudio prospectivo, de tipo caso-control concurrente en 88 pacientes con pre-eclampsia e igual número de controles. El trabajo se llevó a cabo en el Servicio de Obstetricia del Hospital Nacional Cayetano Heredia entre los meses de marzo a agosto de 1993. Resultados: Los factores asociados a pre-eclampsia fueron el antecedente previo a pre-eclampsia (OR:17)...

  2. Incidencia de anemia ferropénica y factores asociados en las gestantes del distrito de Rapayan, Ancash, Perú: Periodo mayo 2010 - marzo 2011

    OpenAIRE

    Vite Gutiérrez, Flor Yessenia

    2011-01-01

    Objetivo: Conocer la incidencia de anemia ferropénica y factores asociados en la gestación en el distrito de Rapayan, Ancash, Perú. Material y método: estudio prospectivo, analítico y longitudinal en 39 gestantes del distrito de Rapayán, provincia de Huari, departamento de Ancash, Perú durante el periodo comprendido entre mayo 2010 y marzo del 2011. Se procedió a tomar muestras de sangre del total de la muestra n= 39 gestantes, durante los tres trimestres con el fin de controlar los niveles d...

  3. Intervención profiláctica no farmacológica en gestantes de riesgo de hipertensión arterial en un hogar materno

    OpenAIRE

    Canciano Chirino, Ernesto; Río Ponciano, Orlando; Machín Noa, Odalis; Cabo Báez, Yadira; Rodríguez Hernández, Marialis; Ramos Junco, Idalma

    2012-01-01

    Introducción: el manejo profiláctico no farmacológico en gestantes de riesgo de hipertensión arterial tiene escasos resultados, por pobre apego al tratamiento. Objetivos: analizar los resultados de una intervención profiláctica no farmacológica en gestantes con más de 2 factores de riesgo de hipertensión arterial tratadas en el Hogar Materno (HM), de otras seguidas ambulatoriamente, se evaluó: evolución del índice de masa corporal (IMC), control de las cifras tensionales según tiempo de gesta...

  4. Marcadores de estrés oxidativo en placentas de gestantes añosas

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    Silvia Suárez

    2007-12-01

    Full Text Available Introducción: Un factor de riesgo alto ginecoobstétrico que contribuye a la morbimortalidad materna perinatal es la edad materna mayor de 35 años. Es posible que el estado oxidativo en la placenta de la gestante añosa sea mayor a la de la gestante no añosa. Objetivo: Evaluar el estado oxidativo de la placenta en gestantes mayores de 35 años. Diseño: Estudio observacional y transversal. Lugar: Hospital Nacional Docente Materno Infantil San Bartolomé y Centro de Investigación de Bioquímica y Nutrición de la Universidad Nacional Mayor de San Marcos. Material biológico: 28 placentas de gestantes de 35 años o más y 28 placentas de gestantes de menos de 35 años, obtenidas de partos vaginales a término. Intervenciones: La muestra de placenta se homogenizó al 10% con buffer fosfato 10 mM, pH 7,4, se centrifugó a 2000 rpm por 5’. Parte del sobrenadante se usó para analizar lipoperoxidación y glutatión (GSH; el sobrenadante restante fue centrifugado a 42 000 rpm por 1 hora, para medir actividad de superóxido dismutasa (SOD. Principales medidas de resultados: Estado oxidativo de placentas obtenidas de mujeres añosas y no añosas. Resultados: La actividad de la SOD y el contenido de GSH placentarios en añosas fue 43,52 U/g de tejido y 4,67 µmol/mL x 10-²; para el grupo control fueron 54,13 U/g de tejido y 6,02 µmol/mL x 10-², respectivamente; en ambos hubo significancia estadística (p < 0,05. La medición de TBARS (lipoperoxidación no mostró diferencias significativas. Conclusiones: Las placentas obtenidas de mujeres añosas muestran menor capacidad de defensa antioxidante frente a las placentas obtenidas de mujeres no añosas.

  5. Anestesia para cesariana em gestante com hipoplasia de aorta distal: relato de caso Anestesia para cesárea en embarazada con hipoplasia de aorta distal: relato de caso Anesthesia for cesarean section on a pregnant woman with hypoplasia of the distal aorta: case report

    Directory of Open Access Journals (Sweden)

    Leonardo de Andrade Reis

    2008-02-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: Anomalias vasculares maternas, potencialmente graves para o feto, podem colocar em risco a perfusão uterina, suscitando cuidados ainda maiores por parte da equipe anestésica. O objetivo deste relato foi mostrar a conduta anestésica para operação cesariana em uma gestante com hipoplasia de aorta distal, logo abaixo da emergência das artérias renais, com estenose da artéria renal e ausência de artérias ilíacas. RELATO DO CASO: Paciente de 30 anos, 54 kg, na segunda gestação com uma cesariana anterior sem intercorrências. Durante a realização de ecografia gestacional na 12ª semana observou-se interrupção da aorta logo abaixo da saída das artérias renais. A paciente foi encaminhada para a realização de cineangiocoronariografia que mostrou hipoplasia da aorta distal abaixo das artérias renais, com ausência das artérias ilíacas. Durante a investigação clínica a paciente mostrou-se assintomática, com exceção de hipertensão arterial e claudicação aos grandes esforços. A paciente foi submetida à anestesia peridural contínua, com titulação da dose anestésica necessária à realização da cesariana. Inicialmente foram injetados 50 mg de bupivacaína a 0,5% sem vasoconstritor e 10 µg de sufentanil. Quinze minutos após, a anestesia foi complementada com mais 25 mg de bupivacaína a 0,5%, o que foi suficiente para atingir adequado nível de bloqueio. A cesariana transcorreu sem intercorrências e a criança nasceu em boas condições clínicas. CONCLUSÕES: O uso de anestesia peridural contínua com doses fracionadas demonstrou ser uma técnica anestésica segura para a realização desse procedimento por reduzir os riscos de hipotensão arterial materna inerente ao bloqueio espinal e também por minimizar a transferência placentária de fármacos, que ocorrem quando do emprego da anestesia geral. A titulação de fármacos através do cateter peridural possibilitou atingir nível anest

  6. Deseos, aptitudes y conocimientos sobre lactancia materna de gestantes en su tercer trimestre

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    Remigio Rafael Gorrita Pérez

    2012-06-01

    Full Text Available Introducción: la lactancia materna es la única forma natural de alimentar al bebé, y una forma inigualable de facilitar el alimento ideal para su crecimiento y desarrollo. Métodos: se realizó un estudio descriptivo, transversal, para evaluar deseos, aptitudes y conocimientos sobre lactancia materna en el tercer trimestre de 114 gestantes del Policlínico "Mártires del 9 de Abril", de San José de las Lajas. Entre marzo de 2010 y de 2011 se valoraron sus historias de salud individual y familiar, y se aplicó a tal efecto un cuestionario con 22 preguntas. Resultados: la información se incorporó a una base de datos y se utilizó para el análisis el estadígrafo chi cuadrado, que se consideró significativo con p< 0,05. La totalidad de las gestantes deseaban amamantar. Dos terceras partes se consideraron aptas o muy aptas para hacerlo, y que poseían los conocimientos necesarios para lograrlo, pero solo algo más de la quinta parte demostró que los poseía. La mayoría de las futuras madres se encontraban entre los 20 y 35 años, el nivel de escolaridad más frecuentemente alcanzado fue el técnico o preuniversitario (en 60 de ellas, para el 52,6 %, y el 46,5 % de las gestantes mantenían una unión consensuada, el 40,3 % eran casadas, y 15 solteras (13,2 %, aspectos que, indiscutiblemente influyen en los resultados. Conclusiones: además de otros resultados alcanzados, la investigación arrojó que aunque la totalidad de las gestantes en su tercer trimestre deseaban lactar a su futuro bebé y las dos terceras partes se consideraban aptas o muy aptas para hacerlo y con conocimientos suficientes al respecto, solo algo más de la quinta parte demostró efectivamente poseerlos.

  7. Programa de atención integral a la adolescente gestante

    Directory of Open Access Journals (Sweden)

    Gloria Esperanza Zambrano-Plata

    2017-06-01

    Full Text Available El presente artículo es el resultado del programa de atención integral dirigido a las adolescentes gestantes y ejecutado en la Unidad Básica Comuneros de la ESE IMSALUD. Este programa, brinda atención a las usuarias de acuerdo a lo definido en la norma técnica 0412 del 2000 para el control prenatal y detección de las alteraciones del embarazo; además , de incluir un componente biosicosocial y educativo donde se involucra a la pareja y familia a fin de prevenir y controlar factores de riesgo para obtener hijos y madres sanas. Participaron 167 gestantes adolescentes entre los 16 a 19 años con nivel educativo media secundaria, de nivel socioeconómico 1 y 2, pertenecientes a los regímenes subsidiado y vinculado. Durante el desarrollo del programa, a las usuarias se les realizo el control prenatal el cual se conforma de anamnesis, examen físico, revisión de paraclínicos, remisión a medicina general, odontología y sicología para el manejo integral de la gestante. El componente educativo se realizaba en forma individual y grupal mediante el curso: “Preparación para la Maternidad y la Paternidad”, los contenidos se centraban en la preparación para el parto y la crianza, detección y control de factores de riesgo, fortalecimiento del autoestima, proyecto de vida y rol materno y paterno, empleándose metodologías dinámicas adaptadas a las características de las usuarias. Igualmente se realizaba visita domiciliara durante la gestación y el puerperio con el propósito de detectar tempranamente y controlar factores de riesgo ambientales, de estilos de vida y del entorno familiar.

  8. Preeclampsia and breast cancer

    DEFF Research Database (Denmark)

    Pacheco, Nadja Livia Pekkola; Andersen, Anne-Marie Nybo; Kamper-Jørgensen, Mads

    2015-01-01

    BACKGROUND: In parous women preeclampsia has been associated with reduced risk of developing breast cancer. Characteristics of births following preeclamptic pregnancies may help understand mechanisms involved in the breast cancer risk reduction inferred by preeclampsia. METHODS: We conducted...... a register-based cohort study of all Danish women giving birth during 1978-2010 (n = 778,701). The association between preeclampsia and breast cancer was evaluated overall and according to birth characteristics by means of incidence rate ratios (IRR) estimated in Poisson regression models. RESULTS: Compared...... with women with non-preeclamptic pregnancies only, women with one or more preeclamptic pregnancies were 19% significantly less likely to develop breast cancer (IRR = 0.81 [95% CI 0.72-0.93]). We found some indication of greater risk reduction in women with term births, one or more previous births...

  9. Why preeclampsia still exists?

    Science.gov (United States)

    Chelbi, Sonia T; Veitia, Reiner A; Vaiman, Daniel

    2013-08-01

    Preeclampsia (PE) is a deadly gestational disease affecting up to 10% of women and specific of the human species. Preeclampsia is clearly multifactorial, but the existence of a genetic basis for this disease is now clearly established by the existence of familial cases, epidemiological studies and known predisposing gene polymorphisms. PE is very common despite the fact that Darwinian pressure should have rapidly eliminated or strongly minimized the frequency of predisposing alleles. Consecutive pregnancies with the same partner decrease the risk and severity of PE. Here, we show that, due to this peculiar feature, preeclampsia predisposing-alleles can be differentially maintained according to the familial structure. Thus, we suggest that an optimal frequency of PE-predisposing alleles in human populations can be achieved as a result of a trade-off between benefits of exogamy, importance for maintaining genetic diversity and increase of the fitness owing to a stable paternal investment. Copyright © 2013 Elsevier Ltd. All rights reserved.

  10. Fibroma de ovario en una gestante joven

    Directory of Open Access Journals (Sweden)

    Martha Lazo Pérez

    2015-02-01

    Full Text Available Se presenta el caso clínico de una gestante de 24 años de edad, quien acudió al Cuerpo de Guardia del Hospital Provincial Ginecoobstétrico Docente "Mariana Grajales Coello" de Santiago de Cuba, por presentar dolor en la parte baja del vientre, además de náuseas y estreñimiento. Se consideró el diagnóstico de fibroma de ovario, que fue definitivo luego de intervenirle quirúrgicamente y realizar el estudio anatomopatológico. Posteriormente se mantuvo el seguimiento clínico en consulta externa; la paciente evolucionó favorablemente y mantuvo su embarazo hasta tener a su hijo -- un recién nacido sano y a término -- a través de parto eutócico

  11. Seroprevalencia del virus linfotropo T humano tipo 1 (HTLV-1 en gestantes y grupos de elevada prevalencia para enfermedades de transmisión sexual de Ayacucho, Perú

    Directory of Open Access Journals (Sweden)

    Zoraida Juscamaita P

    2004-10-01

    Full Text Available Mediante encuestas sero-epidemiológicas se determinó la prevalencia de HTLV-1 en gestantes que acudieron a control prenatal al Hospital Regional de Ayacucho, ciudad andina del Perú, y en grupos de alta prevalencia para enfermedades de transmisión sexual (GEPETS. Las muestras séricas fueron tamizadas con el método de ELISA y finalmente confirmadas con el método de inmunoensayo en línea (INNO-LIA. Se enroló a 602 gestantes de las cuales 3 fueron positivas (0,5% y 3 indeterminadas (0,5. Todas las 85 trabajadoras sexuales fueron negativas, mientras que 2 de 74 homo/bisexuales (2,7% fueron indeterminados. En conclusión, la seroprevalencia de HTLV-1 en gestantes de Huamanga fue baja. La ausencia de casos positivos en los GEPETS contrasta con lo informado en nuestro país.

  12. Gestantes HIV positivas e sua não-adesão à profilaxia no pré-natal=HIV positive pregnant women who do not follow the prenatal prophylaxis=Mujeres embarazadas con HIV positivo y su non adhesión a la profilaxia en el prenatal

    OpenAIRE

    Cechim, Petrolina Libana; Perdomini, Fernanda Rosa Indriunas; Quaresma, Lisiane Moitin

    2007-01-01

    Este é um estudo exploratório descritivo com abordagem qualitativa. Investigamos a não-adesão de gestantes portadoras do vírus HIV/AIDS ao tratamento preconizado pelo Ministério da Saúde no período pré-natal. Os sujeitos desta pesquisa foram sete mulheres soropositivos, que, durante a gestação, não aderiram ao tratamento profilático recomendado. Os dados foram coletados por uma entrevista semiestruturada. Para a análise dos dados, elaboramos categorias com base nas falas destes sujeitos. Com ...

  13. La inequidad en el acceso a la atención odontológica de las mujeres gestantes en Santander

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    Sonia Constanza Concha Sánchez

    2014-04-01

    Full Text Available Introducción: Las condiciones de vida, salud, atención y cuidado de las gestantes están comprometidas, en especial en las mujeres más pobres y vulnerables, y el componente bucal ejerce un papel importante en esta inequidad. Objetivo: Describir las condiciones sociales y económicas que determinan la inequidad en el acceso a la atención odontológica de las mujeres gestantes en Santander. Metodología: Se realizó un estudio observacional analítico de corte transversal que incluyó 8695 gestantes en las que se analizó variables relacionadas con área geográfica, con el sistema de atención y en la mujer gestante variables demográficas, condición bucal y asistencia a consulta odontológica. Para el análisis univariado se calcularon medidas de resumen y para el bivariado se relacionó la asistencia a la consulta odontológica con las variables que determinan su asistencia a la consulta odontológica, para ello se aplicó test de chi². Conclusión: Los determinantes económicos y sociales relacionados con el bajo nivel de desarrollo del municipio, la residencia en zona rural, ser vinculada o usuaria del régimen subsidiado y ser mayor de 40 años influencian la atención odontológica de las mujeres gestantes en Santander

  14. Vascular dysfunction in preeclampsia.

    Science.gov (United States)

    Brennan, Lesley J; Morton, Jude S; Davidge, Sandra T

    2014-01-01

    Preeclampsia is a complex disorder which affects an estimated 5% of all pregnancies worldwide. It is diagnosed by hypertension in the presence of proteinuria after the 20th week of pregnancy and is a prominent cause of maternal morbidity and mortality. As delivery is currently the only known treatment, preeclampsia is also a leading cause of preterm delivery. Preeclampsia is associated with maternal vascular dysfunction, leading to serious cardiovascular risk both during and following pregnancy. Endothelial dysfunction, resulting in increased peripheral resistance, is an integral part of the maternal syndrome. While the cause of preeclampsia remains unknown, placental ischemia resulting from aberrant placentation is a fundamental characteristic of the disorder. Poor placentation is believed to stimulate the release of a number of factors including pro- and antiangiogenic factors and inflammatory activators into the maternal systemic circulation. These factors are critical mediators of vascular function and impact the endothelium in distinctive ways, including enhanced endothelial oxidative stress. The mechanisms of action and the consequences on the maternal vasculature will be discussed in this review. © 2013 John Wiley & Sons Ltd.

  15. Calciuria and preeclampsia

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    Ramos J.G.L.

    1998-01-01

    Full Text Available Urinary calcium excretion has been reported to be diminished in preeclampsia. The objective of the present study was to determine urinary calcium excretion in pregnant patients with chronic arterial hypertension (CAH and preeclampsia (PE, and in normotensive patients (N. Forty-four pregnant patients (gestional age, 20-42 weeks; 18 CAH, 17 PE, 9 N were evaluated for calciuria, proteinuria, plasma uric acid and blood pressure. Patients with PE (82 ± 15.1 mg/24 h showed significantly lower calciuria (P<0.05 than the group with CAH (147 ± 24.9 mg/24 h and the N group (317 ± 86.0 mg/24 h (P<0.05, Student t-test. Plasma uric acid was significantly higher in the PE group (6.1 ± 0.38 mg/dl than the CAH group (5.0 ± 0.33 mg/dl; P<0.05, which also presented higher proteinuria levels, although the difference was not statistically significant. Diastolic and systolic blood pressure did not differ between the PE (164 ± 105 mmHg and CAH (164 ± 107 mmHg groups. Calciuria was significantly lower in the group with preeclampsia than in the group with chronic arterial hypertension. We conclude that calciuria can be a further factor for identifying preeclampsia

  16. Niveles de plomo en gestantes y neonatos en la ciudad de la Oroya, Perú

    Directory of Open Access Journals (Sweden)

    Jorge Castro-Bedriñana

    Full Text Available Objetivos. Determinar los niveles de plomo (Pb en gestantes y neonatos en la ciudad de La Oroya, Perú. Materiales y métodos. Se realizó un estudio transversal. La población estuvo conformada por gestantes residentes durante al menos dos años en la ciudad de La Oroya, cuando operaban normalmente las fundiciones de Pb, cobre y zinc. Se obtuvo muestras de sangre de la gestante antes del parto y luego del parto se tomaron muestras de placenta y sangre del cordón umbilical. El nivel de Pb de dichas muestras fue evaluado por espectrometría de absorción atómica con horno de grafito. Se determinaron regresiones cuadráticas y correlaciones de Pearson. Resultados. Se evaluó cuarenta partos normales. Los niveles promedio de Pb en la sangre materna, cordon umbilical y placenta fueron 27,4 ± 15,6 ug/dL; 19,0 ± 12,6 ug/dL y 319,0 ± 215,9 ug/100 g, respectivamente. El 67,5% de los neonatos tuvieron más de 10 ug/dL de Pb. El nivel de Pb de la sangre del cordón umbilical representó el 69,4% del nivel de Pb en sangre materna. Los coeficientes de correlación entre el Pb de la sangre materna y cordón umbilical, sangre materna y placenta, placenta y sangre del cordón umbilical fueron 0,36; 0,48 y 0,33, respectivamente. Conclusiones. Cuando funcionaba la fundición, las gestantes y recién nacidos tenían concentraciones elevadas de Pb en sangre. Las concentraciones de Pb en la placenta y cordón umbilical tuvieron una correlación moderada con el Pb de la sangre materna. El Pb de la sangre materna y cordón umbilical fue 1,5 veces más alto que los de zonas más alejadas

  17. Water immersion in preeclampsia.

    Science.gov (United States)

    Elvan-Taşpinar, Ayten; Franx, Arie; Delprat, Constance C; Bruinse, Hein W; Koomans, Hein A

    2006-12-01

    Preeclampsia is associated with profound vasoconstriction in most organ systems and reduced plasma volume. Because water immersion produces a marked central redistribution of blood volume and suppresses the renin-angiotensin system response and sympathetic activity, we hypothesized that water immersion might be useful in the treatment of preeclampsia. The effects of thermoneutral water immersion for 3 hours on central and peripheral hemodynamics were evaluated in 7 preeclamptic patients, 7 normal pregnant control patients, and 7 nonpregnant women. Finger plethysmography was used to determine hemodynamic measurements (cardiac output and total peripheral resistance), and forearm blood flow was measured by strain gauge plethysmography. Postischemic hyperemia was used to determine endothelium-dependent vasodilation. Analysis was by analysis of variance for repeated measurements. During water immersion cardiac output increased while diastolic blood pressure and heart rate decreased, although systolic blood pressure remained unchanged in each group. Forearm blood flow increased significantly in the normal pregnant and preeclamptic subjects. Total peripheral resistance decreased in all groups, but values in preeclamptic patients remained above those of normotensive pregnant women. Water immersion had no effect on endothelium-dependent vasodilation in the preeclamptic group, and most hemodynamic changes that were observed reversed to baseline within 2 hours of completion of the procedure. Although water immersion results in hemodynamic alterations in a manner that is theoretically therapeutic for women with preeclampsia, the effect was limited and short-lived. In addition water immersion had no effect on endothelium-dependent vasodilation in women with preeclampsia. The therapeutic potential for water immersion in preeclampsia appears to be limited.

  18. Interleukins in preeclampsia

    International Nuclear Information System (INIS)

    Olusi, Samuel O.; Diejomahoh, M.; Omu, A.; Abdulaziz, A.; Prabha, K.; George, S.

    2000-01-01

    Preeclampsia is a multisystemic disorder of unknown etiology. Recently,endothelial damage has been implicated in its cause. The objective of thisstudy was to determine the role of interleukins in the etiology ofpreeclampsia. 32 primigravidas with preeclampsia but without any clinicalevidence of infection and 32 age-matched primigravidas with uncomplicatednormal pregnancies were investigated. Phlebotomy was performed at 32 weeks ofgestation and blood collected for immunoassay of interleukin-2 (IL-2),interleukin-2 receptor (IL-2R), interleukin-6 (IL-6), interleukin-8 (IL-8)andvinterleukin-10 (IL-10), using commercially available immunoassay kits.Although the maternal plasma concentrations of IL-2 and IL-2R were slightlyhigher in normal pregnant women (76.3+-13.7 pg/mL and 526+-47.1pg/mL,respectively) than in women with preeclampsia (57.8+-1.08 pg/mL and476.9+-3.9pg/mL, respectively), the difference was not statistically significant(P>0.05). However, maternal plasma IL-6 and IL-8 concentrations weresignificantly higher (P<0.05) in normal pregnancy (158.0+-35.4 pg/mL and5163.6+- 800pg/mL, respectively) than in pregnancy complicated withpreeclampsia (60.0+-13.7 pg/mL and 2495.8+-729 pg/mL, respectively). On thepther hand, maternal plasma concentration of IL-10 was significantly higher(P<0.05) in preeclampsia (93.2+-24.1 pg/mL) than in normal pregnancy(31.0+-7.0 pg/mL). It is concluded that the elevated maternal plasma IL-10concentration in preeclampsia may be protective response to maternalimmunorejection. (author)

  19. Assistência de Enfermagem na opinião das mulheres com pré-eclâmpsia Asistencia de Enfermería en la opinión de las mujeres con preeclampsia Nursing assistance in the opinion of women with pre-eclampsia

    Directory of Open Access Journals (Sweden)

    Karla Joelma Bezerra Cunha

    2007-06-01

    Full Text Available Estudo qualitativo cujo objeto é a assistência de enfermagem na ótica das mulheres com pré-eclâmpsia. Os objetivos foram descrever os motivos da hospitalização e suas expectativas; e discutir a assistência de enfermagem recebida em uma maternidade pública de Teresina - PI. A metodologia utilizada foi um formulário semi-estruturado cuja coleta dos dados foi realizada através da entrevista. Os resultados foram apresentados em categorias evidenciando como motivos mais comuns que levaram às 12 mulheres a internação: edema e cefaléia. A assistência de enfermagem prestada limitou-se à verificação da pressão arterial e administração de medicamentos. Quanto à satisfação referiram-se a realização dos procedimentos técnicos e a insatisfação destacou-se pela falta de atenção, apoio e diálogo. O relacionamento equipe de enfermagem-paciente foi considerado frio, impessoal e descompromissado. No entanto, há expectativas de maior humanização na equipe e o estabelecimento de ações confiáveis e motivacionais. Conclui-se que a assistência de enfermagem deva ser mais humana no atendimento às necessidades físicas, sociais e psicoemocionais dos clientesEstudio cualitativo cuyo objeto es la ayuda de enfermería en la óptica de las mujeres con preeclampsia. Los objetivos fueron describir las razones de la hospitalización y sus expectativas; y, discutir la ayuda de enfermería recibida en una maternidad pública de Teresina Piauí (Brasil. La metodología usada fué el un formulario medio estructurado cuya colecta de datos fué hecha a través de la entrevista. Los resultados fueron presentados en categorías que evidenciaban como razones más comunes que llevaran las 12 mujeres a internación: edema y dolor de cabeza crónica. La ayuda de enfermería prestada fue limitada a la verificación de la presión arterial y administración de medicina. Cuánto a la satisfacción fué mencionada la realización de los procedimientos

  20. La alimentación de la gestante adolescente: el cambio favorable

    Directory of Open Access Journals (Sweden)

    ISABEL RODRÍGUEZ HERNÁNDEZ

    2010-06-01

    Full Text Available El presente estudio de tipo cualitativo y etnográfico de pequeño alcance, tiene como objetivo describir el significado del cuidado de sí de un grupo de gestantes adolescentes y su hijo por nacer, con relación a la alimentación, a partir de sus prácticas, creencias y valores culturales, quienes asistieron a control prenatal a la Unidad de Atención Primaria (UPA de Candelaria la Nueva, Hospital Vista Hermosa, Ciudad Bolívar, Localidad 19 de Bogotá, en 2007. La información fue aportada por ocho adolescentes primigestantes de entre 17 y 19 años de edad, que estaban entre el cuarto y séptimo meses de gestación, sin patologías asociadas, que asistieron al primer control prenatal, seleccionadas intencionalmente y que estuvieron dispuestas a participar de la investigación (previo consentimiento informado. La recolección de datos se realizó a través de la entrevista etnográfica no estructurada; se obtuvo como resultado el significado del cuidado en las gestantes adolescentes y se aportaron tres grandes beneficios positivos del cuidado de la alimentación materna: cambio de hábito alimentario, alimentarse para proteger la salud del bebé y para que nazca sano, y alimentarse para proteger la salud de la madre adolescente. Dichos resultados, conjugados en el escenario cultural de las gestantes adolescentes, permiten explorar y conocer cómo se cuidan ellas a través de las prácticas soportadas en el saber como conocimiento y razón, y el uso como los artefactos que utiliza.

  1. Nutritional approach to preeclampsia prevention.

    Science.gov (United States)

    Achamrah, Najate; Ditisheim, Agnès

    2018-05-01

    Although not fully understood, the physiopathology of preeclampsia is thought to involve an abnormal placentation, diffuse endothelial cell dysfunction and increased systemic inflammation. As micronutrients play a key role in placental endothelial function, oxidative stress and expression of angiogenic factors, periconceptional micronutrient supplementation has been proposed to reduce the risk of preeclampsia. However, recent studies reported conflicting results. Calcium intake (>1 g/day) may reduce the risk of preeclampsia in women with low-calcium diet. Data from recently updated Cochrane reviews did not support routine supplementation of vitamins C, E or D for either the prevention or treatment of preeclampsia. Evidences are also poor to support zinc or folic acid supplementation for preeclampsia prevention. Dark chocolate, flavonoid-rich food, and long-chain polyunsaturated fatty acids might also be candidates for prevention of preeclampsia. Through antioxidant, anti-inflammatory or vasoactive proprieties, micronutrients are good candidates for preeclampsia prevention. Calcium supplementation is recommended to prevent preeclampsia in women with low-calcium intake. Despite positive clinical and in-vitro data, strong evidence to support periconceptional supplementation of other micronutrients for preeclampsia risk-reduction is still lacking. Further studies are also needed to evaluate the benefit of nutritional supplementation such as chocolate and long-chain polyunsaturated fatty acids.

  2. Consequences of gestosis (preeclampsia

    Directory of Open Access Journals (Sweden)

    V. N. Perfilova

    2014-01-01

    Full Text Available The review presents the results of an analysis of the data available in the Russian and foreign literature, which show that severe gestosis (preeclampsia is a main cause of perinatal morbidity and mortality. Severe gestosis leads to impaired fetal growth and development, premature births, the development of perinatal hypoxic lesions of the central nervous, cardiovascular, endocrine, immune, respiratory, and other systems, which adversely affects the health status of children in their later life. Women with a history of preeclampsia or eclampsia are further at increased risk for cardiovascular (atherosclerosis, coronary heart disease, peripheral arterial diseases, and hypertension, cerebrovascular diseases, abnormalities of the kidney and organs of vision, diabetes, and memory impairments.

  3. Molecular Mechanisms of Preeclampsia

    OpenAIRE

    N. Vitoratos; D. Hassiakos; C. Iavazzo

    2012-01-01

    Preeclampsia is a pregnancy-specific disease characterized by new onset hypertension and proteinuria after 20 wk of gestation. It is a leading cause of maternal and fetal morbidity and mortality worldwide. Exciting discoveries in the last decade have contributed to a better understanding of the molecular basis of this disease. Epidemiological, experimental, and therapeutic studies from several laboratories have provided compelling evidence that an antiangiogenic state owing to alterations in ...

  4. Hepatic rupture in preeclampsia

    International Nuclear Information System (INIS)

    Winer-Muram, H.T.; Muram, D.; Salazar, J.; Massie, J.D.

    1985-01-01

    The diagnosis of hepatic rupture in patients with pregnancy-induced hypertension (preeclampsia and eclampsia) is rarely made preoperatively. Diagnostic imaging can be utilized in some patients to confirm the preoperative diagnosis. Since hematoma formation precedes hepatic rupture, then, when diagnostic modalities such as sonography and computed tomography identify patients with hematomas, these patients are at risk of rupture, and should be hospitalized until the hematomas resolve

  5. Embryo cryopreservation and preeclampsia risk.

    Science.gov (United States)

    Sites, Cynthia K; Wilson, Donna; Barsky, Maya; Bernson, Dana; Bernstein, Ira M; Boulet, Sheree; Zhang, Yujia

    2017-11-01

    To determine whether assisted reproductive technology (ART) cycles involving cryopreserved-warmed embryos are associated with the development of preeclampsia. Retrospective cohort study. IVF clinics and hospitals. A total of 15,937 births from ART: 9,417 singleton and 6,520 twin. We used linked ART surveillance, birth certificate, and maternal hospitalization discharge data, considering resident singleton and twin births from autologous or donor eggs from 2005-2010. We compared the frequency of preeclampsia diagnosis for cryopreserved-warmed versus fresh ET and used multivariable logistic regression to adjust for confounders. Among pregnancies conceived with autologous eggs resulting in singletons, preeclampsia was greater after cryopreserved-warmed versus fresh ET (7.51% vs. 4.29%, adjusted odds ratio = 2.17 [95% CI 1.67-2.82]). Preeclampsia without and with severe features, preeclampsia with preterm delivery, and chronic hypertension with superimposed preeclampsia were more frequent after cryopreserved-warmed versus fresh ET (3.99% vs. 2.55%; 2.95% vs. 1.41%; 2.76 vs. 1.48%; and 0.95% vs. 0.43%, respectively). Among pregnancies from autologous eggs resulting in twins, the frequency of preeclampsia with severe features (9.26% vs. 5.70%) and preeclampsia with preterm delivery (14.81% vs. 11.74%) was higher after cryopreserved versus fresh transfers. Among donor egg pregnancies, rates of preeclampsia did not differ significantly between cryopreserved-warmed and fresh ET (10.78% vs. 12.13% for singletons and 28.0% vs. 25.15% for twins). Among ART pregnancies conceived using autologous eggs resulting in live births, those involving transfer of cryopreserved-warmed embryos, as compared with fresh ETs, had increased risk for preeclampsia with severe features and preeclampsia with preterm delivery. Copyright © 2017 American Society for Reproductive Medicine. All rights reserved.

  6. Genetics of preeclampsia: paradigm shifts

    NARCIS (Netherlands)

    Oudejans, Cees B. M.; van Dijk, Marie; Oosterkamp, Marjet; Lachmeijer, Augusta; Blankenstein, Marinus A.

    2007-01-01

    Segregation of preeclampsia into early-onset, placental and late-onset, maternal subtypes along with the acknowledgement of the contribution of epigenetics in placentally expressed genes proved to be a key first step in the identification of essential gene variants associated with preeclampsia.

  7. Maternal Preeclampsia and Neonatal Outcomes

    Directory of Open Access Journals (Sweden)

    Carl H. Backes

    2011-01-01

    Full Text Available Preeclampsia is a multiorgan, heterogeneous disorder of pregnancy associated with significant maternal and neonatal morbidity and mortality. Optimal strategies in the care of the women with preeclampsia have not been fully elucidated, leaving physicians with incomplete data to guide their clinical decision making. Because preeclampsia is a progressive disorder, in some circumstances, delivery is needed to halt the progression to the benefit of the mother and fetus. However, the need for premature delivery has adverse effects on important neonatal outcomes not limited to the most premature infants. Late-preterm infants account for approximately two thirds of all preterm deliveries and are at significant risk for morbidity and mortality. Reviewed is the current literature in the diagnosis and obstetrical management of preeclampsia, the outcomes of late-preterm infants, and potential strategies to optimize fetal outcomes in pregnancies complicated by preeclampsia.

  8. Prevalencia de sífilis en mujeres gestantes atendidas por el Programa de Protección a la Gestante (PPG y reporte de aborto en el Estado de Sergipe, Brasil

    Directory of Open Access Journals (Sweden)

    Fernando Saab

    2016-06-01

    Full Text Available Introducción: La sífilis ha representado un importante reto para la salud pública en Brasil, tanto por su alta prevalencia como por las graves secuelas neonatales. Objetivo: Determinar la prevalencia de infección por sífilis y la aparición de abortos involuntarios en mujeres embarazadas, por edad y distribución espacial en el estado de Sergipe en Brasil. Metodología: Estudio transversal descriptivo-retrospectivo, en el que se analizaron 39.807 registros de usuarias del Programa de Protección a la Gestante (PPG ofrecido en 73 municipios en el estado de Sergipe, en un período aproximado de dos años. Resultados: Fueron seleccionadas 39.807 gestantes, de las cuales 7.538 (18,9% reportaron haber abortado, 544 (1,37% fueron halladas con sífilis positiva y 192 (0,48% presentaron sífilis positiva y reporte de aborto. La proporción aumentó de 25,7% de mujeres que abortaron y tuvieron cualquier tipo de alteración (HIV, HTLV, Chagas, Hepatitis B, Hepatitis C, Clamidia, Toxoplasmosis, Rubéola, Citomegalovirus, Hipotiroidismo congénito e Fenilcetonuria materna a 35,3% en mujeres que abortaron y presentaron confirmación de sífilis positiva, representando un aumento de 1,37 veces de los casos. El Municipio de Carmópolis tuvo el mayor porcentaje de casos con 2,19%, seguido de Malhador con un 1.30%, Malhada dos Bois con 1.16%, Estância con 1.15%, Barra dos Coqueiros con 1.14%, Santa Luzia do Itanhy con 1,04% y Pedrinhas con un 1,00%. Conclusión: Se verificó que en la mayoría de los municipios fue elevado el número de registros de abortos involuntarios en mujeres gestantes. La prevalencia gestacional de sífilis fue superior a la aceptada por la Organización Mundial de la Salud (OMS. Por medio del PPG se verificó que la sífilis continúa siendo un importante problema de salud durante la gestación, y que las mujeres con sífilis presentan una mayor frecuencia de abortos.

  9. Revisión Bibliográfica: Relación de la subunidad beta de gonadotropina corionica humana, testosterona libre y sexo fetal con el desarrollo de preeclampsia.

    OpenAIRE

    Francisco A. Yegüez M; Olivar C. Castejón; Marisol García de Yegüez

    2007-01-01

    La hipertensión arterial que complica al embarazo, constituye una patología compleja que comprende entidades clínicas como la preeclampsia (PE), eclampsia (E) y síndrome de HELLP. En su etiopatogenia se imbrican innumerables factores conducentes a disfunción endotelial que desencadena una cascada de manifestacionesclínicas que generan un gran impacto en la salud materno fetal: restricción del crecimiento fetal, parto prematuro y/o asfixia perinatal, abruptio placentae, hemorragias maternas in...

  10. CARACTERIZAÇÃO DE GESTANTES COM TESTE RÁPIDO POSITIVO PARA HIV EM FORTALEZA-CE

    Directory of Open Access Journals (Sweden)

    LÉA MARIA MOURA BARROSO

    2007-01-01

    Full Text Available El objetivo fue describir a las gestantes sometidas al test rápido para detectar VIH/SIDA en una maternidad de Fortaleza- CE, en relación a las características sociodemográficas y clínicas. Estudio transversal del tipo documental retrospectivo, con trece gestantes sometidas al test rápido y con resultado positivo para VIH/SIDA en el periodo de abril de 2002 a abril de 2004. El promedio de edad de las gestantes era 26,2 años; el 61,5% estudió entre cuatro a siete años; el 69,2 % era de la capital y el 30,8 % del interior; el 53,8 % ama de casa; el 54,0 % con cuatro a siete consultas de prenatal; el 46,2 % fue diagnosticada antes del parto; el 84,6 % recibió profilaxis solamente en el parto; el 46,0% tuvo bolsa rota hasta cuatro horas antes del parto; el 77,0% parto quirúrgico y el 100% de los recién nacidos recibió el jarabe de AZT en las primeras dos horas de vida. Se concluye que la institución garantizó la reducción del riesgo de contaminación del recién nacido, sin embargo se percibió deficiencia en los servicios que ofrecieron atención antes del parto.

  11. ADIPONECTINA PLASMÁTICA EN PREECLAMPSIA Y ECLAMPSIA

    OpenAIRE

    Reyna-Villasmil,Eduardo; Mejia-Montilla,Jorly; Reyna-Villasmil,Nadia; Torres-Cepeda,Duly; Peña-Paredes,Elvia

    2008-01-01

    Antecedentes: La adiponectina, una de las proteínas específicas del tejido adiposo, se ha considerado que mejora la sensibilidad a la insulina, inhibe la inflamación vascular y tiene efectos antiaterogénicas, ya que se correlacionan negativamente con la obesidad y dislipidemia. Objetivo: Comparar las concentraciones de adiponectina plasmática en eclámpticas, preeclámpticas y embarazadas normotensas. Método: Se incluyeron 30 pacientes con preeclampsia leve (grupo A), 30 pacientes con preeclamp...

  12. Prevalencia de anemia en gestantes, Hospital Regional de Pucallpa, Perú

    Directory of Open Access Journals (Sweden)

    Becerra César

    1998-01-01

    Full Text Available Las encuestas demográficas de salud y población del Perú indican que las tasas globales de fecundidad, la proporción de adolescentes embarazadas y la mortalidad maternoinfantil son más altas en la selva que en otras zonas del país. Las parasitosis intestinales endémicas agravan el riesgo de anemia ya generalmente presente en las embarazadas por deficiencias de hierro, ácido fólico y otros nutrientes. En muchos países latinoamericanos, esa es la complicación más frecuente del embarazo y está asociada con partos pretérmino, bajo peso al nacer y mortalidad perinatal. Los estudios realizados sobre este tema en la selva peruana son escasos y no se dispone de estimaciones confiables de la prevalencia de anemia durante la gestación. Los autores se propusieron determinar la prevalencia de anemia en mujeres gestantes que acudían al Hospital Regional de Pucallpa, en la selva del Perú, entre enero de 1993 y junio de 1995. El estudio de corte transversal se basó en los registros de control prenatal y de parto de 1 015 embarazadas y permitió estudiar la asociación entre la prevalencia de anemia y variables como edad cronológica, escolaridad, número de gestaciones previas y peso de la madre al inicio del embarazo. También se compararon los valores de la hemoglobina materna con el peso de los recién nacidos. La prevalencia de anemia en la población de gestantes fue de 70,1%, valor que no se modificó por efecto de la edad materna, la escolaridad ni el intervalo intergenésico. La prevalencia de anemia se asoció directamente con el número de gestaciones e inversamente con la ganancia de peso durante el embarazo. La tasa de mortalidad perinatal fue de 37,7 por 1 000 nacidos. Ni esta tasa ni el peso de los recién nacidos resultaron asociados con el grado de anemia de la madre. El análisis de regresión multivariado muestra que el peso de la madre al inicio de la gestación (P = 0,0001, el peso ganado durante la gestación (P = 0

  13. The genetic component of preeclampsia

    DEFF Research Database (Denmark)

    Hansen, Anette Tarp; Bernth Jensen, Jens Magnus; Hvas, Anne-Mette

    2018-01-01

    Preeclampsia is a major cause of maternal and perinatal deaths. The aetiology of preeclampsia is largely unknown but a polygenetic component is assumed. To explore this hypothesis, we performed an in-depth whole-exome sequencing study in women with (cases, N = 50) and without (controls, N = 50......) preeclampsia. The women were identified in an unselected cohort of 2,545 pregnant women based on data from the Danish National Patient Registry and the Medical Birth Registry. Matching DNA was obtained from a biobank containing excess blood from routine antenatal care visits. Novogene performed the whole......-exome sequencing blinded to preeclampsia status. Variants for comparison between cases and controls were filtered in the Ingenuity Variant Analysis software. We applied two different strategies; a disease association panel approach, which included variants in single genes associated with established clinical risk...

  14. Review on pre-eclampsia

    OpenAIRE

    Schlembach, Dietmar

    2003-01-01

    Pre-eclampsia is still one of the leading causes of maternal and fetal morbidity and mortality. Despite active research for many decades, the etiology of this disorder exclusive to human pregnancy is an enigma. Recent evidence suggests there may be several underlying causes or predispositions leading to endothelial dysfunction and causing the signs of hypertension, proteinuria, and edema--findings that allow us to make the diagnosis of the "syndrome" of pre-eclampsia. It is obvious that a sin...

  15. [Evans syndrome, pregnancy, and preeclampsia].

    Science.gov (United States)

    Hernández-Salazar, E; Martínez-Abundis, C E; González-Ortiz, C M

    2001-02-01

    Evans' syndrome is an unusual illness of autoimmune etiology, characterized by thrombocytopenia and hemolytic anemia. This is more frequent in females throughout first half of the life and during pregnancy. The present paper describes two pregnant women with Evans syndrome associated to preeclampsia. This report emphasizes how the hematology and coagulation abnormalities of preeclampsia could be added to those abnormalities observed in Evans' syndrome. This association constitutes a severe disease of difficult treatment.

  16. Sentimentos diante da não amamentação de gestantes e puérperas soropositivas para HIV

    Directory of Open Access Journals (Sweden)

    Simone de Paiva Sousa

    2004-01-01

    Full Text Available Investigación entre las mujeres embarazadas y parturientes portadoras de VIH sobre cuales son los sentimientos que vivenciam por el hecho de no poder amamantar. Se trata de un estudio cualitativo realizado desde octubre hasta diciembre del 2003 en Fortaleza-Ceará. Fueron aplicadas entrevistas semi-estructuradas a cinco mujeres gestantes y ocho parturientes portadoras de VIH. Los resultados señalaron que las mujeres gestantes y las parturientes expresan que la maternidad seria completa se fuera efetivo el acto de amamentamiento. Mencionaron que el motivo de no amamantar les produce sentimientos: culpa, frustraciones, sufrimiento, deseos interrumpidos, imposibilidad y sueños no realizados. Sin embargo, también, expresaran sentimiento de indiferencia delante del hecho puntual de no amamantar. Concluimos que las mujeres con VIH manifestaron las dificultades físicas, barata y psicológicas antes de no amamantar.

  17. Prevalência do diagnóstico de enfermagem: nutrição desequilibrada mais do que as necessidades corporais em gestantes Prevalencia del diagnóstico de enfermería: nutrición desequilibrada más que las necesidades corporales en gestantes Prevalence of the nursing diagnosis, imbalanced nutrition: more than body requirements, in pregnant women

    Directory of Open Access Journals (Sweden)

    Escolástica Rejane Ferreira Moura

    2012-01-01

    Full Text Available OBJETIVO: Identificar a prevalência do Diagnóstico de Enfermagem (DE nutrição desequilibrada: mais do que as necessidades corporais em gestantes e verificar a associação entre o DE e as variáveis sociodemográficas e obstétricas. MÉTODOS: Estudo transversal, descritivo,exploratório, realizado com 146 gestantes atendidas em unidades básicas de saúde de Município da região metropolitana de Fortaleza(Ceará. Os dados foram coletados por meio de formulário durante consulta de enfermagem ao pré-natal. Foram realizados o cálculo do Índice de Massa Corporal e da mensuração da dobra da pele do tríceps. RESULTADOS: O DE em estudo foi determinado em 100 (68,4% gestantes. Verificou-se diferença estatística significativa da idade entre gestantes com e sem o DE (p= 0,001; paridade (p= 0,026 e idade gestacional (p= 0,002. CONCLUSÃO: O DE pesquisado apresentou prevalência marcante nas gestantes pesquisadas, estando associado a fatores evitáveis por ações educativas voltadas ao planejamento familiar, como idade materna e paridade.OBJETIVO: Identificar la prevalencia del Diagnóstico de Enfermería (DE nutrición desequilibrada: más que las necesidades corporales en gestantes y verificar la asociación entre el DE y las variables sociodemográficas y obstétricas. MÉTODOS: Estudio transversal, descriptivo, exploratorio, realizado con 146 gestantes atendidas en unidades básicas de salud del Municipio de la región metropolitana de Fortaleza(Ceará. Los dados fueron recolectados por medio de un formulario durante la consulta de enfermería al prenatal. Fueron realizados el cálculo del Índice de Masa Corporal y de la mensuración del doblez cutáneo del triceps. RESULTADOS: El DE en estudio fue determinado en 100 (68,4% gestantes. Se verificó una diferencia estadística significativa de la edad entre gestantes con y sin el DE (p= 0,001; paridad (p= 0,026 y edad gestacional (p= 0,002. CONCLUSIÓN: El DE investigado presentó marcada

  18. Postpartum Depression After Mild and Severe Preeclampsia

    NARCIS (Netherlands)

    Hoedjes, Meeke; Berks, Durk; Vogel, Ineke; Franx, Arie; Bangma, Meike; Darlington, Anne-Sophie E.; Visser, Willy; Duvekot, Johannes J.; Habbema, J. Dik F.; Steegers, Eric A. P.; Raat, Hein

    2011-01-01

    Objective: To describe the prevalence of postpartum depressive symptoms after preeclampsia, to assess the extent to which the prevalence of postpartum depressive symptoms differs after mild and severe preeclampsia, and to investigate which factors contribute to such differences. Methods: Women

  19. C-reactive protein and later preeclampsia

    DEFF Research Database (Denmark)

    Rebelo, Fernanda; Schlüssel, Michael M; Vaz, Juliana S

    2013-01-01

    This study aims to determine whether high C-reactive protein (CRP) concentration during pregnancy is associated with later preeclampsia and whether weight status (BMI) is a potential modifier of the relation between CRP and preeclampsia....

  20. Searching for preeclampsia genes : the current position

    NARCIS (Netherlands)

    Lachmeijer, AMA; Dekker, GA; Pals, G; Aarnoudse, JG; ten Kate, LP; Arngrimsson, R

    2002-01-01

    Although there is substantial evidence that preeclampsia has a genetic background, the complexity of the processes involved and the fact that preeclampsia is a maternal-fetal phenomenon does not make the search for the molecular basis of preeclampsia genes easy. It is possible that the single

  1. Atividade fisica em gestantes assistidas na atencao primaria a saude

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    Maria Antonieta de Barros Leite Carvalhaes

    2013-10-01

    Full Text Available OBJETIVO Analisar o padrão de atividade física de gestantes de baixo risco e os fatores associados. MÉTODOS Estudo transversal com 256 gestantes adultas no segundo trimestre gestacional, sorteadas dentre as assistidas pelas unidades de atenção primária à saúde do município de Botucatu, SP, em 2010. As atividades físicas foram investigadas por meio do “pregnancy physical activity questionnaire”, verificando-se tempo e intensidade de atividades ocupacionais, de deslocamento, domésticas e de lazer, expressos em equivalentes metabólicos dia. As gestantes foram classificadas segundo nível de atividade e em relação a atingir 150 min/semana de atividades físicas de lazer, variáveis dependentes do estudo. A associação entre essas variáveis e as socioeconômicas, características maternas, fatores comportamentais e modelo de atenção da unidade de saúde foi avaliada mediante modelos de regressão de Poisson com variância robusta, adotando-se modelo hierárquico. RESULTADOS A maior parte das gestantes era insuficientemente ativa (77,7%, 12,5% moderadamente ativa e 9,8% vigorosamente ativa. Os maiores gastos diários de energia foram com atividades domésticas, seguidas pelas atividades de locomoção; 10,2% atingiram a recomendação de 150 min semanais de atividades físicas de lazer. Trabalho fora de casa reduziu a chance de atingir essa recomendação (RP = 0,39, IC95% 0,16;0,93. Ter tido pelo menos um parto anterior (RP = 0,87, IC95% 0,77;0,99 e excesso ponderal pré-gestacional (RP = 0,85, IC95% 0,731;0,99 reduziram a chance de ser insuficientemente ativa, enquanto consumir menos alimentos saudáveis teve aumento discreto (RP = 1,18, IC95% 1,02;1,36. CONCLUSÕES Gestantes assistidas na atenção primária à saúde são insuficientemente ativas. Ter tido pelo menos um parto e apresentar sobrepeso pré-gestacional foram identificados como fatores protetores contra tal situação, enquanto consumo menos frequente de alimentos

  2. Necesidades de conocimientos de profesionales de la salud sobre la atención a la gestante y madre adolescente

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    Rosa María Alonso Uría

    Full Text Available Introducción : el embarazo en la adolescente constituye un problema de salud; ya que es una etapa en que no existe la madurez necesaria para cumplir el rol de madre, lo cual repercute en el desarrollo futuro de ella y sus descendientes. Objetivos: Identificar las necesidades de conocimientos sobre la atención integral a las gestantes y madres adolescentes en profesionales de la salud que laboran en los municipios de Regla y Guanabacoa. Métodos : se realizó una investigación descriptiva, prospectiva y transversal, se diseñó un cuestionario aplicado en el periodo octubre-diciembre de 2012, con temas necesarios para la atención integral. Resultados : se logró reunir a 100 profesionales que acudieron en el momento de la aplicación. El 43 % presentó una calificación entre 70 y 79 puntos, 29 % entre 80 y 89; y un 15 % entre 60 y 69. Solo un 7 % obtuvo muy buenos conocimientos. Los temas de mayor carencia fueron, complicaciones del embarazo en la adolescencia, utilización de métodos anticonceptivos y anticoncepción de emergencia, manejo del neonato, técnica y ventajas de la lactancia materna. Es notoria la impericia en la psicoprofilaxis; así como el desconocimiento de la frecuencia en que deben realizarse las consultas de seguimiento a las gestantes, puérperas adolescentes y sus recién nacidos. Conclusiones: existen necesidades de conocimientos en los profesionales para el manejo integral y correcto a la adolescente gestante y madre, así como en las orientaciones para la crianza de su descendiente. Se necesita una estrategia de superación profesional para satisfacer las carencias cognitivas.

  3. Estudo comparativo entre bupivacaína racêmica a 0,25% e bupivacaína com excesso enantiomérico de 50% (S75-R25 a 0,25%, associadas ao fentanil para analgesia de parto com deambulação da parturiente Estudio comparativo entre bupivacaína racémica a 0,25% y bupivacaína con exceso enantiomérico de 50% (S75-R25 a 0,25% asociadas con fentanil para analgesia de parto con deambulación de la gestante Racemic 0.25% bupivacaine and 50% enantiomeric excess (S75-R25 0.25% bupivacaine associated to fentanyl for labor analgesia with patient’s ambulation. Comparative study

    Directory of Open Access Journals (Sweden)

    Carlos Alberto Figueiredo Côrtes

    2006-02-01

    ógiros de los anestésicos locales demostraron mayor seguridad debido a la menor cardiotoxicidad. La deambulación de la gestante durante el trabajo de parto por lo que puede abreviar la duración del parto. Este estudio compara la calidad de la analgesia y las repercusiones materno fetales así como la capacidad de deambular y de orinar en forma espontánea de las gestantes, usando bupivacaína a 0,25% y bupivacaína con exceso enantiomérico de 50% (S75-R25 a 0,25% asociadas con fentanil por vía peridural continua durante el trabajo de parto. MÉTODO: Fueron evaluadas 40 gestantes, estado físico ASA I y II, con feto único y en trabajo de parto, que recibieron analgesia peridural continua, divididas en 2 grupos. En el grupo I recibieron 8 mL (20 mg de bupivacaína (S75-R25 a 0,25% con epinefrina asociados a 100 µg de fentanil. En el grupo II recibieron 8 ml (20 mg de bupivacaína racémica a 0,25% con epinefrina asociados a 100 µg de fentanil. Los siguientes parámetros fueron evaluados: tiempo de latencia, altura del bloqueo sensitivo, grado de bloqueo motor, examen de Romberg, capacidad de deambular y orinar en forma espontánea, duración del trabajo de parto y del período expulsivo, variables maternas respiratorias y hemodinámicas y la vitalidad de los neonatos. RESULTADOS: No hubo diferencia estadística entre los grupos en los parámetros evaluados. Todas las gestantes tenían fuerza muscular y capacidad para deambular, pero esto no ocurrió en un caso del grupo II por indicación de cesárea y en 4 casos del grupo I porque el parto ocurrió antes de iniciar la evaluación motora. CONCLUSIONES: Tanto la bupivacaína a 0,25% como la bupivacaína (S75-R25 a 0,25% asociadas con fentanil demostraron ser una buena opción para analgesia de parto.BACKGROUND AND OBJECTIVES: Clinical studies with levogyrous enantiomers of local anesthetics have shown better safety due to lower cardiotoxicity. Parturients ambulation during labor may be able to shorten it. This study

  4. Caracterización de las gestantes de alto riesgo obstétrico (ARO en el departamento de Sucre (Colombia, 2015

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    Judith Martínez Royert

    2016-01-01

    Full Text Available Objetivo: Caracterizar las gestantes de Alto Riesgo Obstétrico ( ARO que acuden a una IPS pública en el departamento de Sucre, Colombia (periodo enero, febrero y marzo de 2015. Material y métodos: Estudio cuantitativo, descriptivo. La muestra la conformaron 123 gestantes ARO . Se utilizó un instrumento elaborado por las investigadoras; se sometió a validez de constructo y contenido, y análisis de consistencia interna mediante el alfa de Cronbach. Resultados: El 13,18 % de las gestantes eran menores de 18 años; 38,2% procedentes de la capital y 19,5 % de la región del San Jorge; 66 % no manifestaron antecedentes patológicos; 13,8 % presentaron complicaciones de amenaza de aborto o de parto pretérmino; 37 % eran nulípara; 20.3 % tenían cesárea anterior; 22.8 % sufrieron abortos; 54.5 % manifestaron tensión emocional y mal humor; 82.9% no programaron el embarazo; 24 % con periodo intergenésico de 1 año; 55.3 % (68 gestantes se encontraban entre la semana 30 y 40 de gestación al momento de participar en el estudio. Conclusiones: La subregión de la Sabana y San Jorge fueron las que presentaron mayor número de gestantes de alto riesgo. Entre las patologías preexistentes más frecuentes se encontró anemias y migrañas, así como las del sistema endocrino y respiratorio. Esta investigación servirá como referente para proporcionar conocimiento respecto al perfil de las gestantes de alto riesgo en Sucre, para que los profesionales involucrados en su atención desempeñen un rol que permita contribuir al control y prevención de las complicaciones en ellas y en la reducción significativa de la mortalidad materna.

  5. Índice de alimentação saudável para gestantes: adaptação para uso em gestantes brasileiras Índice de alimentación saludable para gestantes: adaptación para uso en gestantes brasileñas Healthy eating index for pregnancy: adaptation for use in pregnant women in Brazil

    Directory of Open Access Journals (Sweden)

    Cristiane Melere

    2013-02-01

    Full Text Available OBJETIVO: Avaliar a qualidade global da dieta em uma amostra de gestantes, a partir de um parâmetro único, simples e objetivo. MÉTODOS: Gestantes entre a 16ª e 36ª semana de gestação (n = 712 foram arroladas em unidades básicas de saúde em Porto Alegre e Bento Gonçalves, RS, em 2010. Com base no índice americano Alternate Healthy Eating Index for Pregnancy (AHEI-P foi criado o Índice de Alimentação Saudável para Gestantes Brasileiras (HEIP-B. Foram aplicados o questionário de frequência alimentar e o questionário sociodemográfico. Foi utilizada a análise de componentes principais focada para avaliar a relação entre os índices e os nutrientes relevantes à gestação. RESULTADOS: A mediana e o intervalo interquartílico dos índices AHEI-P e HEIP-B foram 66,6 (57,8-72,4 e 67,4 (60,0-73,4, respectivamente. O HEIP-B mostrou boa correlação positiva com os nutrientes que têm recomendação específica no período gestacional folato (r = 0,8; p OBJETIVO: Evaluar la calidad global de la dieta en una muestra de gestantes, a partir de um parámetro único, simple y objetivo. MÉTODOS: Gestantes entre 16ª y 36ª semana de gestación (n=712 fueron inventariadas en unidades básicas de salud en Porto Alegre y Bento Gonçalves, RS, Brasil, en 2010. Con base en el índice americano Alternate Healthy Eating Index for Pregnancy (AHEI-P se creó en índice de Alimentación Saludable para Gestantes (HEIP-B. Se aplicaron el cuestionario de frecuencia alimentaria y el cuestionario sociodemográfico. Se utilizó el análisis de componentes principales para evaluar la relación entre los índices y los nutrientes relevantes para la gestación. RESULTADOS: La mediana y el intervalo intercuartil de los índices AHEI-P y HEIP-B fueron 66,6 (57,8-72,4 y 67,4 (60,0-73,4, respectivamente. El HEIP-B mostró buena correlación positiva con los nutrientes que tienen recomendación específica en el período gestacional folato (r = 0,8; p OBJECTIVE

  6. Immunology and Genetic of Preeclampsia

    Directory of Open Access Journals (Sweden)

    Norma C. Serrano

    2006-01-01

    Full Text Available Preeclampsia is a disease characterized by hypertension and proteinuria in the third trimester of pregnancy. Preeclampsia is a major cause of maternal mortality, and fetal death, especially in developing countries, but its aetiology remains unclear. Key findings support a causal role of superficial placentation driven by immune mal maladaptation, which then lead to reduced concentrations of angiogenic growth factors and to an increase in placental debris in the maternal circulation resulting in a maternal inflammatory response. Epidemiological research has consistently demonstrated a substantial familial predisposition to preeclampsia. Unfortunately, the conquest of the genes explaining such a individual susceptibility has been proved to be a hard task. However, genetics will also inform us about causality of environmental factors, and then serve as a tool to prioritize therapeutic targets for preventive strategies.

  7. Preeclampsia: from Pathophysiology to Treatment

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    Kaculini Enton

    2016-12-01

    Full Text Available Preeclampsia is a multisystem disorder unique to human pregnancy and is its most common glomerular complication. It occurs in 2% to 8% of pregnancies and is a major contributor to maternal mortality worldwide. Although the pathophysiology of this syndrome is not fully understood, many pathogenetic mechanisms are involved in this disorder. The role of the placenta is crucial in the development of this disorder. Some pathogenetic mechanisms involved in this disease comprise defective deep placentation, autoantibodies to type-1 angiotensin II receptor, endothelial dysfunction, oxidative stress, platelet and thrombin activation, intravascular inflammation, and the imbalance between angiogenic and antiangiogenic factors which is thought to be one of the most crucial mechanisms. Further understanding of the full picture could enhance our current knowledge of the pathogenesis of preeclampsia and improve its treatment. Thus, based on specific biomarkers the diagnosis and subclassification of preeclampsia might be more accurate in identifying patients at risk, monitoring disease progression and providing effective interventions

  8. Genética y preeclampsia

    OpenAIRE

    Quiroga de Michelena, María Isabel; Diaz Kuan, Alicia

    2014-01-01

    La preeclampsia es una condición multifactorial y compleja cuya etiología continúa en estudio. La identificación de los genes involucrados en la preeclampsia puede ser la antesala para disponer de marcadores que puedan predecir y/o detectar la preeclampsia, así como el descubrimiento de tratamientos específicos y personalizados. Preeclampsia is a multifactorial and complex condition whose etiology continues in study. Identification of genes involved in preeclampsia may lead to markers that...

  9. Disfunción familiar en gestantes adolescentes de un área de salud

    Directory of Open Access Journals (Sweden)

    Iliana de la Caridad Calderón Morales

    2014-11-01

    Full Text Available Se realizó un estudio descriptivo, observacional, de corte transversal, de las 58 gestantes menores de 20 años, pertenecientes al área de salud del Policlínico Universitario "Josué País García" de Santiago de Cuba, de enero a diciembre del 2013, con vistas a determinar la relación entre la disfunción familiar y la presentación del embarazo en ellas, para lo cual se aplicó el instrumento de evaluación Faces III. Al efectuar el análisis estadístico se evidenció un predominio del grupo etario de 15-18 años, de la vinculación a los diferentes niveles de enseñanza en correspondencia con la edad, así como de la disfuncionalidad familiar y el tipo de familia extensa; estos 2 últimos resultados constituyeron factores predisponentes en el desarrollo de conductas de riesgo, como el embarazo precoz

  10. Consumo de frutas, verduras e legumes por gestantes adolescentes

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    Antônia Caroline Diniz Brito

    2016-11-01

    Full Text Available Objetivo: Determinar o estado nutricional e os fatores associados ao consumo alimentar de frutas, verduras e legumes por gestantes adolescentes atendidas em um serviço público de referência para assistência pré-natal. Métodos: Estudo transversal e analítico, com 73 gestantes adolescentes de 10 a 19 anos, atendidas no Núcleo de Assistência ao Adolescente (NASA do Hospital Materno Infantil, em São Luís, Maranhão. Utilizou-se o Questionário de Frequência de Consumo Alimentar (QFCA, medidas antropométricas (peso, altura, índice de massa corporal - IMC - pré-gravídico e gravídico e questionário socioeconômico. As variáveis dependentes foram o consumo de frutas, verduras e legumes, e as independentes foram escolaridade, estado civil, raça, renda, situação demográfica, dados gestacionais e antropométricos. Resultados: Observou-se que 39,7% apresentaram IMC pré-gestacional de desnutrição, 50,7% de eutrofia, e menos de 10% sobrepeso ou obesidade. Para o IMC gestacional, os valores se alteraram, com 27,4% das gestantes desnutridas, 57,5% eutróficas e 15,1% com sobrepeso. Observou-se que os maiores percentuais de adequação para o consumo de frutas, verduras e legumes foram em adolescentes casadas ou em união estável (65,4%, que não trabalhavam (92,3% e com renda familiar menor que 1 salário mínimo (84,62%. Entretanto, a única associação positiva encontrada com o consumo de frutas, verduras e legumes foi o início do pré-natal. Conclusão: A maior parte das gestantes avaliadas apresentou-se eutrófica, apesar de cerca de um quarto apresentar baixo peso durante a gestação. Além disso, elas não consumiam uma dieta balanceada, com uma ingestão abaixo do recomendado de FVL. Entre os fatores relacionados a um melhor consumo de FVL destaca-se o início do acompanhamento pré-natal no primeiro trimestre.

  11. Preeclampsia, Hypoxia, Thrombosis, and Inflammation

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    Amir A. Shamshirsaz

    2012-01-01

    Full Text Available Reductions in uteroplacental flow initiate a cascade of molecular effects leading to hypoxia, thrombosis, inflammation, and endothelial cell dysfunction resulting in untoward pregnancy outcomes. In this review, we detail these effects and their relationship to preeclampsia (PE and intrauterine growth restriction (IUGR.

  12. Epigenetic Placental Programming of Preeclampsia

    Science.gov (United States)

    Preeclampsia (PE) affects 8-10% of women in the US and long-term consequences include subsequent development of maternal hypertension and hypertension in offspring. As methylation patterns are established during fetal life, we focused on epigenetic alterations in DNA methylation as a plausible expla...

  13. Estado nutricional del hierro en gestantes adolescentes, Medellín, Colombia / Nutritional status of iron in pregnant adolescents, Medellín, Colombia

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    Beatriz E. Parra S

    2014-04-01

    Full Text Available Objetivo: analizar el estado nutricional del hierro en gestantes adolescentes de tercer trimestre. Metodología: estudio analítico de corte transversal con 276 adolescentes entre 10 y 19 años, en tercer trimestre de gestación de la Empresa Social del Estado (ese Metrosalud (Medellín, 2011-2012, con datos de hemoglobina, volumen corpuscular medio, concentración de hemoglobina corpuscular media e ingesta de suplemento de hierro. La ferritina sérica se analizó en 178 gestantes, controlada por proteína C-reactiva. Se utilizaron medidas de tendencia central, dispersión, porcentajes y pruebas de Chi2 , anova, Kruskal-Wallis y U de Mann-Whitney. Resultados: la prevalencia de anemia fue 17,1% en el tercer trimestre de gestación y por deficiencia de hierro, 51%. La mediana de ferritina sérica fue 13,3 µg/L (RQ: 7,7 µg/L-17,9 µg/L; sólo el 5,6% (n = 9 presentó valores adecuados de ferritina. Las madres que tomaron suplemento de hierro diariamente presentaron mejores concentraciones de hemoglobina y ferritina, frente a aquellas que no lo hicieron, Hb 12,1g/dL vs. 11,7 g/dL (p = 0,019 y ferritina sérica 14,6 µg/L vs. 7,0 µg/L (p = 0,000. Discusión: hubo altas prevalencias de anemia y ferropenia en las gestantes, asociadas con la no adherencia al suplemento de hierro Objetivo: analizar el estado nutricional del hierro en gestantes adolescentes de tercer trimestre. Metodología: estudio analítico de corte transversal con 276 adolescentes entre 10 y 19 años, en tercer trimestre de gestación de la Empresa Social del Estado (ese Metrosalud (Medellín, 2011-2012, con datos de hemoglobina, volumen corpuscular medio, concentración de hemoglobina corpuscular media e ingesta de suplemento de hierro. La ferritina sérica se analizó en 178 gestantes, controlada por proteína C-reactiva. Se utilizaron medidas de tendencia central, dispersión, porcentajes y pruebas de Chi2 , anova, Kruskal-Wallis y U de Mann-Whitney. Resultados: la prevalencia

  14. Pesando riscos e benefícios: lições aprendidas com as intervenções terapêuticas de um caso com pré-eclâmpsia grave Balance entre beneficios y riesgos: lecciones aprendidas con las intervenciones terapéuticas de un caso con preclampsia grave Balancing the benefits and risks: lessons learned from the therapeutic interventions of a case with severe preeclampsia

    Directory of Open Access Journals (Sweden)

    Shiqin Xu

    2013-06-01

    érias.JUSTIFICATIVA Y OBJETIVOS: La preclampsia es un síndrome de la disfunción de múltiples órganos (SDMO debido a sus manifestaciones típicas y atípicas que incluyen hipertensión, proteinuria, síndrome HELLP, encefalopatía hipertensiva y coagulopatía. El manejo ideal de esos pacientes necesita una evaluación del balance entre los beneficios y riesgos de las estrategias terapéuticas, anestésicas y obstétricas. RELATO DE CASO: Paciente embarazada de 35 años, con un embarazo anterior sin complicaciones, llegó a nuestro instituto médico en carácter de urgencia a las 29 semanas de embarazo. La paciente estaba con mareos, molestias en el pecho, cardiopalmia, visión nublada y sangramiento vaginal. Posteriormente al examen físico y laboratorial, la paciente fue diagnosticada con preclampsia grave, síndrome HELLP, desplazamiento prematuro de la placenta y SDMO. La paciente también presentaba una deformidad de la columna vertebral y pélvica, fijación de la articulación mandibular y desplazamiento traqueal debido a un accidente de tránsito ocurrido hacía 11 años. Por tanto, se realizó una cesárea de urgencia con anestesia general con intubación nasotraqueal usando un cable guía. La paciente recibió alta directamente de la unidad de cuidados intensivos obstétrica (UCI-OB al séptimo día del postoperatorio, con una presión arterial normal y la recuperación completa de las funciones orgánicas. CONCLUSIONES: Este caso merece una discusión más detallada sobre las consideraciones anestésicas al momento de tomar una decisión clínica para el tratamiento de tal paciente. El bloqueo del neuro eje es la primera elección para pacientes con preclampsia sometidas a la cesárea cuando existe una trombocitopenia moderada, pero no progresiva. Cuando se opta por la anestesia general, una sedación y una analgesia adecuadas se hacen necesarias para el buen control de la respuesta del estrés a la intubación, especialmente en los pacientes con signos neurológicos, y

  15. Ejercicio y depresión en mujeres embarazadas con sobrepeso y obesidad: ensayo clínico aleatorio

    OpenAIRE

    Perales, María; Cordero, Y.; Vargas, M.; Lucía Mulas, Alejandro; Barakat, Rubén

    2015-01-01

    El objetivo de este trabajo es evaluar la eficacia de un programa de ejercicio físico regular en la prevención de la depresión en mujeres gestantes con sobrepeso y obesidad. Para ello, se llevó a cabo un ensayo clínico aleatorio en el Hospital Universitario de Fuenlabrada en Madrid. Un total de 106 mujeres gestantes sanas con sobrepeso y obesidad (32,70±3,90 años), sin complicaciones y con gestación simple fueron analizadas (52 en el grupo de ejercicio (GE) y 54 en el grupo de contro...

  16. Profilaxis de la hipertensión arterial tipo III con el uso de la aspirina

    OpenAIRE

    Rodríguez Santana, Maricela; García León, Lázaro; Valdés Suárez, Ernesto; Hernández Cabrera, Jesús

    1997-01-01

    Se realiza un estudio, en el período comprendido entre enero de 1994 hasta enero con 1995, de 104 gestantes diagnosticadas como hipertensas crónicas en la consulta externa del hospital docente ginecoobstétrico de Matanzas. Del total de la muestra, 54 fueron tratadas con dosis bajas en aspirina y en 50 no se aplicó este tratamiento. Las gestantes que utilizaron bajas dosis de aspirina, no desarrollaron hipertensión arterial tipo III (HTA III), ni se presentaron en las mismas complicaciones mat...

  17. Estado nutricional y seguridad alimentaria en gestantes adolescentes: Pereira, Colombia, 2009 Estado nutricional e segurança alimentaria em gestantes adolescentes: Pereira, Colombia, 2009 Nutritional status and food safety in teenage pregnant women: Pereira, Colombia, 2009

    Directory of Open Access Journals (Sweden)

    Rocío Quintero Tabares

    2010-07-01

    Full Text Available Objetivo. Valorar estado nutricional y percepción de seguridad alimentaria, de gestantes adolescentes consultantes en Instituciones de la ESE Salud Pereira durante el año 2009. Metodología. Estudio descriptivo de corte transversal. Con un 95% de nivel de confianza, se seleccionó una muestra de 150 gestantes, entre las asistentes al control prenatal durante los meses abril a junio de 2009. Se capacitaron cuatro encuestadores enfermeros profesionales. Se aplicó la encuesta y la Escala Latinoamericana y Caribeña de Seguridad Alimentaria. Se realizó valoración nutricional a partir de los registros en la historia clínica de biomarcadores e indicadores antropométricos y obstétricos. Se realizó análisis univariado y bivariado. Resultados. El 95% de las gestantes adolescentes eran de estratos I y II, el 59% con escolaridad secundaria incompleta, el 79% primigrávidas. El 21% tenía bajo peso pregestacional y el 45% bajo peso durante la gestación. El 15% mostró anemia. El 33% reportó infección urinaria. El 8.7% tenía riesgo de HIE. El 63.3% de las gestantes percibía algún grado de inseguridad alimentaria, que era severa en el 22.7% de los hogares. Conclusión. Se encontró una alta proporción de bajo peso pregestacional no compensado oportunamente. Debido al impacto de la seguridad alimentaria sobre la nutrición en el embarazo, su monitoreo debe ser incluido como una de las actividades básicas en la atención prenatal.Objetivo. Valorizar estado nutricional e percepção de segurança alimentaria, de gestantes adolescentes consultados em Instituições da ESSE Saúde Pereira durante o ano 2009. Metodologia. Estudo descritivo de corte transversal. Com um 95% de nível de confiança, selecionouse uma mostra de 150 gestantes, entre as assistentes ao controle pré-natal durante os meses abril a junho de 2009. Capacitaram-se quatro pesquisadores enfermeiros profissionais. Aplicou-se a enquete e a Escala Latino-americana e Caribenha de

  18. ANÁLISIS DE COMPONENTES PRINCIPALES APLICADO A VARIABLES RESPECTO A LA MUJER GESTANTE EN LA REGIÓN DE LAS AMÉRICAS

    OpenAIRE

    Salinas P,Hugo; Albornoz V,Jaime; Reyes P,Alvaro; Erazo B,Marcia; Ide V,Rodolfo

    2006-01-01

    Objetivo: Obtener índices comparativos entre países, respecto a la real situación de la mujer gestante _recursos utilizados y resultados obtenidos_ en la Región de las Américas. Material y Métodos: Se recopila información oficial de los países de la Región de las Américas, publicada por OMS y OPS, correspondiente a variables relacionadas con la mujer embarazada y los recursos potenciales utilizados en su atención, además de los resultados obtenidos en dicha atención. Se estudiaron 9 variables...

  19. Preeclampsia and the Anti-Angiogenic State

    OpenAIRE

    Agarwal, Isha; Karumanchi, S. Ananth

    2011-01-01

    Preeclampsia is a major cause of maternal and fetal morbidity and mortality worldwide, however, its etiology remains unclear. Abnormal placental angiogenesis during pregnancy resulting from high levels of anti-angiogenic factors, soluble Flt1 (sFlt1) and soluble endoglin (sEng), has been implicated in preeclampsia pathogenesis. Accumulating evidence also points to a role for these anti-angiogenic proteins as serum biomarkers for the clinical diagnosis and prediction of preeclampsia. Uncoverin...

  20. NEW DEVELOPMENTS IN THE PATHOGENESIS OF PREECLAMPSIA

    OpenAIRE

    Naljayan, Mihran V.; Karumanchi, S. Ananth

    2013-01-01

    Preeclampsia affecting 3-5% of all pregnancies is a major cause of maternal and perinatal morbidity and mortality worldwide. This disorder is characterized by a constellation of signs and symptoms, most notably new onset hypertension and proteinuria during the last trimester of pregnancy. In this review, the molecular mechanisms of preeclampsia with an emphasis on the role of circulating anti-angiogenic proteins in the pathogenesis of preeclampsia and its complications will be discussed.

  1. Role of fetal DNA in preeclampsia (review).

    Science.gov (United States)

    Konečná, Barbora; Vlková, Barbora; Celec, Peter

    2015-02-01

    Preeclampsia is an autoimmune disorder characterized by hypertension. It begins with abnormal cytotrophoblast apoptosis, which leads to inflammation and an increase in the levels of anti-angiogenic factors followed by the disruption of the angiogenic status. Increased levels of fetal DNA and RNA coming from the placenta, one of the most commonly affected organs in pregnancies complicated by preeclampsia, have been found in pregnant women with the condition. However, it remains unknown as to whether this is a cause or a consequence of preeclampsia. Few studies have been carried out on preeclampsia in which an animal model of preeclampsia was induced by an injection of different types of DNA that are mimic fetal DNA and provoke inflammation through Toll-like receptor 9 (TLR9) or cyclic guanosine monophosphate-adenosine monophosphate (cGAMP). The specific mechanisms involved in the development of preeclampsia are not yet fully understood. It is hypothesized that the presence of different fragments of fetal DNA in maternal plasma may cause for the development of preeclampsia. The function of DNase during preeclampsia also remains unresolved. Studies have suggested that its activity is decreased or the DNA is protected against its effects. Further research is required to uncover the pathogenesis of preeclampsia and focus more on the condition of patients with the condition.

  2. Protein profiling of preeclampsia placental tissues.

    Science.gov (United States)

    Shu, Chang; Liu, Zitao; Cui, Lifeng; Wei, Chengguo; Wang, Shuwen; Tang, Jian Jenny; Cui, Miao; Lian, Guodong; Li, Wei; Liu, Xiufen; Xu, Hongmei; Jiang, Jing; Lee, Peng; Zhang, David Y; He, Jin; Ye, Fei

    2014-01-01

    Preeclampsia is a multi-system disorder involved in pregnancy without an effective treatment except delivery. The precise pathogenesis of this complicated disorder is still not completely understood. The objective of this study is to evaluate the alterations of protein expression and phosphorylations that are important in regulating placental cell function in preterm and term preeclampsia. Using the Protein Pathway Array, 38 proteins in placental tissues were found to be differentially expressed between preterm preeclampsia and gestational age matched control, while 25 proteins were found to be expressed differentially between term preeclampsia and matched controls. Among these proteins, 16 proteins and their associated signaling pathways overlapped between preterm and term preeclampsia, suggesting the common pathogenesis of two subsets of disease. On the other hand, many proteins are uniquely altered in either preterm or term preeclampsia and correlated with severity of clinical symptoms and outcomes, therefore, providing molecular basis for these two subsets of preeclampsia. Furthermore, the expression levels of some of these proteins correlated with neonatal small for gestational age (PAI-1 and PAPP-A) and adverse outcomes (Flt-1) in women with preterm preeclampsia. These proteins could potentially be used as candidate biomarkers for predicting outcomes of preeclampsia.

  3. MONOCYTES AND MACROPHAGES IN PREGNANCY AND PREECLAMPSIA

    Directory of Open Access Journals (Sweden)

    Marijke M Faas

    2014-06-01

    Full Text Available Preeclampsia is an important complication in pregnancy, characterized byhypertension and proteinuria in the second half of pregnancy. Generalizedactivation of the inflammatory response is thought to play a role in thepathogenesis of preeclampsia. Monocytes may play a central role in thisinflammatory response. Monocytes are short lived cells, that mature in thecirculation and invade into tissues upon an inflammatory stimulus anddevelop into macrophages. Macrophages are abundantly present in theendometrium and play a role in implantation and placentation in normalpregnancy. In preeclampsia, these macrophages appear to be present in largernumbers and are also activated. In the present review we focused on the roleof monocytes and macrophages in the pathophysiology of preeclampsia.

  4. Protein profiling of preeclampsia placental tissues.

    Directory of Open Access Journals (Sweden)

    Chang Shu

    Full Text Available Preeclampsia is a multi-system disorder involved in pregnancy without an effective treatment except delivery. The precise pathogenesis of this complicated disorder is still not completely understood. The objective of this study is to evaluate the alterations of protein expression and phosphorylations that are important in regulating placental cell function in preterm and term preeclampsia. Using the Protein Pathway Array, 38 proteins in placental tissues were found to be differentially expressed between preterm preeclampsia and gestational age matched control, while 25 proteins were found to be expressed differentially between term preeclampsia and matched controls. Among these proteins, 16 proteins and their associated signaling pathways overlapped between preterm and term preeclampsia, suggesting the common pathogenesis of two subsets of disease. On the other hand, many proteins are uniquely altered in either preterm or term preeclampsia and correlated with severity of clinical symptoms and outcomes, therefore, providing molecular basis for these two subsets of preeclampsia. Furthermore, the expression levels of some of these proteins correlated with neonatal small for gestational age (PAI-1 and PAPP-A and adverse outcomes (Flt-1 in women with preterm preeclampsia. These proteins could potentially be used as candidate biomarkers for predicting outcomes of preeclampsia.

  5. Protein Profiling of Preeclampsia Placental Tissues

    Science.gov (United States)

    Shu, Chang; Liu, Zitao; Cui, Lifeng; Wei, Chengguo; Wang, Shuwen; Tang, Jian Jenny; Cui, Miao; Lian, Guodong; Li, Wei; Liu, Xiufen; Xu, Hongmei; Jiang, Jing; Lee, Peng; Zhang, David Y.

    2014-01-01

    Preeclampsia is a multi-system disorder involved in pregnancy without an effective treatment except delivery. The precise pathogenesis of this complicated disorder is still not completely understood. The objective of this study is to evaluate the alterations of protein expression and phosphorylations that are important in regulating placental cell function in preterm and term preeclampsia. Using the Protein Pathway Array, 38 proteins in placental tissues were found to be differentially expressed between preterm preeclampsia and gestational age matched control, while 25 proteins were found to be expressed differentially between term preeclampsia and matched controls. Among these proteins, 16 proteins and their associated signaling pathways overlapped between preterm and term preeclampsia, suggesting the common pathogenesis of two subsets of disease. On the other hand, many proteins are uniquely altered in either preterm or term preeclampsia and correlated with severity of clinical symptoms and outcomes, therefore, providing molecular basis for these two subsets of preeclampsia. Furthermore, the expression levels of some of these proteins correlated with neonatal small for gestational age (PAI-1 and PAPP-A) and adverse outcomes (Flt-1) in women with preterm preeclampsia. These proteins could potentially be used as candidate biomarkers for predicting outcomes of preeclampsia. PMID:25392996

  6. Polimorfismos genéticos asociados a pre-eclampsia

    OpenAIRE

    Baquero Mejía, Ingrid Carolina

    2013-01-01

    RESUMEN: La pre-eclampsia es un trastorno multisistémico del embarazo y del puerperio, que complica aproximadamente del 6 al 8% de todos los embarazos en los países desarrollados. Es considerada un problema de salud pública debido a su alta prevalencia. Es una de las causas más frecuentes de mortalidad materno-fetal en países en desarrollo, igualmente es causa de preocupación en los países desarrollados por su gran relación causal con el retraso de crecimiento intrauterino y partos prematuro...

  7. Resultados perinatales en mujeres mexicanas con lupus eritematoso sistémico

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    B. Farfan-Labonne

    2017-03-01

    Conclusiones: Las mujeres mexicanas con lupus eritematoso sistémico tienen una alta incidencia de nacimiento pretérmino, preeclampsia, anemia, preeclampsia de inicio temprano, restricción del crecimiento intrauterino y cesárea, si bien la incidencia de nacidos vivos está entre las más altas reportadas en la literatura.

  8. Uso de medicamentos por gestantes em seis cidades brasileiras

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    Mengue Sotero S

    2001-01-01

    Full Text Available OBJETIVO: Descrever os medicamentos utilizados por gestantes que fizeram o pré-natal em serviços do SUS (Sistema Único de Saúde em cidades brasileiras. MÉTODOS: Utilizando-se um questionário estruturado, foram entrevistadas 5.564 gestantes entre a 21ª e a 28ª semanas de gravidez, que se apresentaram para consulta em serviço de pré-natal do SUS em seis grandes cidades brasileiras. As perguntas foram agrupadas em "uso orientado" para dor, cólica, enjôo, tosse e outros e em "medicamento orientado" para vitamina, ferro e flúor. Foi adotada a classificação de risco do FDA (Food and Drug Administration, entre 1991 e 1995. RESULTADOS: Do total de 5.564, 4.614 (83,8% das gestantes usaram pelo menos um medicamento durante a gestação, somando 9.556 medicamentos. Os medicamentos mais utilizados foram as vitaminas associadas a antianêmicos (33,5%, os medicamentos que atuam sobre o aparelho digestivo (31,3%, os analgésicos/antiinflamatórios (22,2%, os antianêmicos (19,8% e os antimicrobianos (11,1%. Quanto à classificação de risco para a gestação, 3.243 (34,0% foram incluídos na categoria A, 1.923 (22,6% na categoria B, 3.798 (39,7% na categoria C, 289 (3,0% na categoria D e 55 (0,6% na categoria X. CONCLUSÕES: Foram observadas grandes variações quanto ao uso de medicamentos, principalmente antianêmicos e vitaminas associadas a antianêmicos, entre as várias cidades estudadas, mostrando a ausência de um padrão nacional quanto ao uso desses medicamentos na gestação. Para uma proporção de 12,9% dos medicamentos utilizados, não foi localizada qualquer informação na literatura sobre a segurança para o uso durante a gestação. Essa proporção, somada aos 26,9% dos medicamentos classificados no grupo "C", mostra que 40% do uso de medicamentos na gestação são feitos sem bases definidas de segurança. Entretanto, medicamentos claramente contra-indicados durante a gestação corresponderam a apenas 3% dos 9

  9. Nutritional status and weight gain in pregnant women Estado nutricional y aumento de peso en la mujer embarazada Estado nutricional e ganho de peso de gestantes

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    Ana Paula Sayuri Sato

    2012-06-01

    Full Text Available This study described the nutritional status of 228 pregnant women and the influence of this on birth weight. This is a retrospective study, developed in a health center in the municipality of São Paulo, with data obtained from medical records. Linear regression analysis was carried out. An association was verified between the initial and final nutritional status (pEstado nutricional de 228 embarazadas y su influencia en el peso al nacer fue caracterizado. Estudio desarrollado en centro de salud de São Paulo con datos obtenidos de registros médicos. Análisis de regresión lineal fue realizado. Se verificó asociación entre estado nutricional inicial y final (pCaracterizou-se estado nutricional de 228 gestantes e sua influência no peso ao nascer. Trata-se de estudo retrospectivo desenvolvido num centro de saúde do município de São Paulo, com dados obtidos de prontuários. Realizou-se análise de regressão linear. Verificou-se associação entre estado nutricional inicial e final (p<0,001. A média de ganho total de peso diminuiu das gestantes que iniciaram a gravidez com baixo peso para aquelas que iniciaram com sobrepeso/obesidade (p=0,005, sendo insuficiente para 43,4 e 36,4% das gestantes com peso inicial adequado e para o total das gestantes estudadas, respectivamente. Entretanto, 37,1% daquelas que iniciaram a gravidez com sobrepeso/obesidade finalizaram com ganho excessivo, condição que, no final, afetou quase um quarto das gestantes. Anemia e baixo peso ao nascer foram pouco frequentes, porém, na análise de regressão linear, peso ao nascer associou-se com ganho de peso (p<0,05. Evidencia-se a importância do cuidado nutricional antes e durante a gravidez, para promoção da saúde materno-infantil.

  10. ÍNDICE ATEROGÉNICO COMO FACTOR DE RIESGO PARA EL SÍNDROME DE PREECLAMPSIA / Atherogenic index as a risk factor for preeclampsia syndrome

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    José P. Rueda Villalpando

    2012-10-01

    Full Text Available ResumenIntroducción y objetivos: La hipertensión inducida por el embarazo o preeclampsia presenta características fisiopatológicas similares a las de la aterosclerosis y las enfermedades cardiovasculares. El propósito del estudio fue identificar los factores de riesgo aterogénico y su relación en la preeclampsia. Método: Se realizó una investigación descriptiva de tipo transversal, con 50 pacientes en el tercer trimestre del embarazo. Mediante la entrevista se establecieron el peso y la talla, para calcular el índice de masa corporal. La tensión arterial > 140/90 mmHg acompañada de edema y proteinuria en el embarazo, se clasificó como hipertensión arterial. Se tomaron muestras de sangre para determinar los valores de colesterol sérico, triglicéridos y HDL. Las variables se expresaron en porcentajes. Resultados: En cada paciente se analizó el número de factores de riesgo y sus asociaciones. Los resultados más relevantes consistieron en que el 76 % presentó sobrepeso u obesidad. En cuanto al síndrome de preeclampsia, se mostró en el 30 % con un riesgo relativo de 3 veces más que las normolipídicas, y 30 % tuvo un índice aterogénico elevado. Conclusiones: La dislipidemia es un factor de riesgo aterogénico de importancia, y en conjunto constituyen un factor de riesgo para la preeclampsia. El incremento del índice aterogénico aumenta la susceptibilidad a la aterogénesis en la preeclampsia. La dislipidemia aparenta ser el punto de inicio de esta cadena de sucesos. El estudio del papel de la dislipidemia podría contribuir a la comprensión de los mecanismos de disfunción endotelial en la preeclampsia. / AbstractIntroduction and Objectives: Pregnancy−induced hypertension or preeclampsia presents pathophysiological features similar to atherosclerosis and cardiovascular disease. Identify atherogenic risk factors and their relationship in preeclampsia was the purpose of this study. Method: We conducted a cross

  11. Automedicación en gestantes que acuden al Instituto Nacional Materno Perinatal, Perú 2011 Self-medication behavior among pregnant women user of the Instituto Nacional Materno Perinatal, Peru 2011

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    Elsy Miní

    2012-06-01

    Full Text Available Con el objetivo de determinar la prevalencia de automedicación en gestantes y sus características, se realizó un estudio descriptivo transversal. Se entrevistó a 400 gestantes que acudían a control prenatal en el Instituto Nacional Materno Perinatal de Lima. El 10,5% (42 pacientes se automedicó durante la gestación, el 64,6% opinó que la automedicación puede producir malformaciones congénitas a sus bebes. Los medicamentos consumidos por las gestantes estuvieron en categoría A y B de la clasificación de la Administración de Alimentos y Drogas de EUA (FDA; principalmente, consumieron paracetamol (47,6% y amoxicilina (16,7%. Todas las mujeres que se automedicaron durante la gestación lo habían hecho antes de estar embarazadas. De acuerdo con estos resultados concluimos que la prevalencia de automedicación en gestantes del estudio es baja, comparado con la literatura internacional.We aim to determine the prevalence of self prescribing behaviour during pregnancy and its characteristics. For this purpose, we designed a cross sectional study and interviewed 400 pregnant women who had their prenatal care at Instituto Nacional Materno Perinatal, Lima. We found that 10.5% of the patients (42 patients had a self prescribing behavior during pregnancy, 64.5% think that self prescribing behavior can produce congenital malformations. The medications used were classified as type A and B according to the Food and Drug Administration (FDA. Paracetamol was used more frequently (47.6% followed by amoxicillin (16.7%. All the women who self-prescribed have had this behavior before pregnancy. According to these results, we conclude there is a low prevalence of self-prescribing behavior during pregnancy compared to the international literature.

  12. Pre-eclampsia: Factores de riesgo. Estudio en el Hospital Nacional Cayetano Heredia.

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    Manuel Salviz Salhuana

    1996-01-01

    Full Text Available Objetivo: El objetivo fue evaluar los factores de riesgo asociados a pre-eclampsia en nuestro hospital. Material y métodos: Se realizó un estudio prospectivo, de tipo caso-control concurrente en 88 pacientes con pre-eclampsia e igual número de controles. El trabajo se llevó a cabo en el Servicio de Obstetricia del Hospital Nacional Cayetano Heredia entre los meses de marzo a agosto de 1993. Resultados: Los factores asociados a pre-eclampsia fueron el antecedente previo a pre-eclampsia (OR:17, el índice de masa corporal elevado (OR:9.6, la raza predominantemente blanca (OR:6.4, el antecedente familiar de hipertensión arterial (OR: 5.2, la falta de control pre-natal y la nuliparidad (OR: 2.5. La incidencia de pre-eclampsia fue 4.11%, y requirieron parto por cesárea el 69.3% de las pacientes. Presentaron complicaciones en el puerperio inmediato 28.4% de los casos, siendo más frecuentes las infecciones. (Rev Med Hered 1996; 7: 24-31.

  13. Anestesia para cesárea en paciente con acondroplasia

    OpenAIRE

    Osorio Rudas, Walter; Socha García, Nury Isabel; Upegui, Alejandro; Ríos Medina, Ángela; Moran, Adrian; Aguirre Ospina, Oscar; Rivera, Carlos

    2012-01-01

    Introducción: En gestantes acondroplásicas se recomienda el parto por cesárea con anestesia general; sin embargo, recientemente se ha reportado el uso de técnicas conductivas con resultados adecuados. Objetivo:Describir el manejo anestésico de una paciente con acondroplasia programada para cesárea utilizando anestesia combinada espinal-epidural. Métodos y resultados:Mostramos el caso de una primigestante acondroplásica con 110 cm de estatura y embarazo de 37 semanas, en quien se realizó cesár...

  14. Preeclampsia: from epidemiological observations to molecular mechanisms

    Directory of Open Access Journals (Sweden)

    P. López-Jaramillo

    2001-10-01

    Full Text Available Preeclampsia is the main cause of maternal mortality and is associated with a five-fold increase in perinatal mortality in developing countries. In spite of this, the etiology of preeclampsia is unknown. The present article analyzes the contradictory results of the use of calcium supplementation in the prevention of preeclampsia, and tries to give an explanation of these results. The proposal of an integrative model to explain the clinical manifestations of preeclampsia is discussed. In this proposal we suggest that preeclampsia is caused by nutritional, environmental and genetic factors that lead to the creation of an imbalance between the free radicals nitric oxide, superoxide and peroxynitrate in the vascular endothelium. The adequate interpretation of this model would allow us to understand that the best way of preventing preeclampsia is the establishment of an adequate prenatal control system involving adequate antioxidant vitamin and mineral supplementation, adequate diagnosis and early treatment of asymptomatic urinary and vaginal infections. The role of infection in the genesis of preeclampsia needs to be studied in depth because it may involve a fundamental change in the prevention and treatment of preeclampsia.

  15. Preeclampsia: at risk for remote cardiovascular disease

    NARCIS (Netherlands)

    Harskamp, Ralf E.; Zeeman, Gerda G.

    2007-01-01

    Epidemiological data indicate that women with preeclampsia are more likely to develop cardiovascular disease (CVD) later in life. Population-based studies relate preeclampsia to an increased risk of later chronic hypertension (RR, 2.00 to 8.00) and cardiovascular morbidity/mortality (RR, 1.3 to

  16. Associations between phenotypes of preeclampsia and thrombophilia.

    Science.gov (United States)

    Berks, Durk; Duvekot, Johannes J; Basalan, Hillal; De Maat, Moniek P M; Steegers, Eric A P; Visser, Willy

    2015-11-01

    Preeclampsia complicates 2-8% of all pregnancies. Studies on the association of preeclampsia with thrombophilia are conflicting. Clinical heterogeneity of the disease may be one of the explanations. The present study addresses the question whether different phenotypes of preeclampsia are associated with thrombophilia factors. Study design We planned a retrospective cohort study. From 1985 until 2010 women with preeclampsia were offered postpartum screening for the following thrombophilia factors: anti-phospholipid antibodies, APC-resistance, protein C deficiency and protein S deficiency, hyperhomocysteineamia, factor V Leiden and Prothrombin gene mutation. Hospital records were used to obtain information on phenotypes of the preeclampsia and placental histology. We identified 844 women with singleton pregnancies who were screened for thrombophilia factors. HELLP complicated 49% of pregnancies; Fetal growth restriction complicated 61% of pregnancies. Early delivery (preeclampsia was associated with protein S deficiency (p=0.01). Fetal growth restriction was associated with anti-phospholipid antibodies (ppreeclampsia was associated with anti-phospholipid antibodies (p=0.01). Extensive placental infarction (>10%) was associated with anti-phospholipid antibodies (ppreeclampsia, especially if complicated by fetal growth restriction, are associated with anti-phospholipid antibodies. Other phenotypes of preeclampsia, especially HELLP syndrome, were not associated with thrombophilia. We advise only to test for anti-phospholipid antibodies after early onset preeclampsia, especially if complicated by fetal growth restriction. We suggest enough evidence is presented to justify no further studies are needed. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  17. Preeclampsia : At risk for remote cardiovascular disease

    NARCIS (Netherlands)

    Harskamp, Ralf E.; Zeeman, Gerda G.

    2007-01-01

    Epidemiological data indicate that women with preeclampsia are more likely to develop cardiovascular disease (CVD) later in life. Population-based studies relate preeclampsia to an increased risk of later chronic hypertension (RR, 2.00 to 8.00) and cardiovascular morbidity/mortality (RR, 1.3 to

  18. Vascular associated gene variants in patients with preeclampsia

    DEFF Research Database (Denmark)

    Lykke, Jacob A; Bare, Lance A; Olsen, Jørn

    2012-01-01

    Preeclampsia has been linked to subsequent vascular disease with many shared predisposing factors. We investigated the association between severe preeclampsia, and its subtypes, and specific vascular-related polymorphisms.......Preeclampsia has been linked to subsequent vascular disease with many shared predisposing factors. We investigated the association between severe preeclampsia, and its subtypes, and specific vascular-related polymorphisms....

  19. Alteration of serum adropin level in preeclampsia.

    Science.gov (United States)

    Wang, Huihua; Gao, Bo; Wu, Zaigui; Wang, Hanzhi; Dong, Minyue

    2017-04-01

    To clarify the alterations in serum adropin and preptin concentrations in preeclampsia, we determined serum adropin and preptin levels in 29 women with normal pregnancy and 32 women with preeclampsia. We found that maternal age, body mass index and fetal gender were not significantly different between two groups; however, blood pressure, gestational age and neonatal birth weight were significantly different. Serum adropin levels were significantly increased in women with preeclampsia compared with those with normal pregnancy but there were no significant differences in preptin levels. An increase in maternal serum adropin level was found in preeclampsia, and this may be a compensation for pregnancy complicated with preeclampsia. Copyright © 2017 International Society for the Study of Hypertension in Pregnancy. Published by Elsevier B.V. All rights reserved.

  20. Environmental noise pollution and risk of preeclampsia.

    Science.gov (United States)

    Auger, Nathalie; Duplaix, Mathilde; Bilodeau-Bertrand, Marianne; Lo, Ernest; Smargiassi, Audrey

    2018-08-01

    Environmental noise exposure is associated with a greater risk of hypertension, but the link with preeclampsia, a hypertensive disorder of pregnancy, is unclear. We sought to determine the relationship between environmental noise pollution and risk of preeclampsia during pregnancy. We analyzed a population-based cohort comprising 269,263 deliveries on the island of Montreal, Canada between 2000 and 2013. We obtained total environmental noise pollution measurements (LA eq24 , L den , L night ) from land use regression models, and assigned noise levels to each woman based on the residential postal code. We computed odds ratios (OR) and 95% confidence intervals (CI) for the association of noise with preeclampsia in mixed logistic regression models with participants as a random effect, and adjusted for air pollution, neighbourhood walkability, maternal age, parity, multiple pregnancy, comorbidity, socioeconomic deprivation, and year of delivery. We assessed whether noise exposure was more strongly associated with severe or early onset preeclampsia than mild or late onset preeclampsia. Prevalence of preeclampsia was higher for women exposed to elevated environmental noise pollution levels (LA eq24h  ≥ 65 dB(A) = 37.9 per 1000 vs. <50 dB(A) = 27.9 per 1000). Compared with 50 dB(A), an LA eq24h of 65.0 dB(A) was not significantly associated the risk of preeclampsia (OR 1.09, 95% CI 0.99-1.20). Associations were however present with severe (OR 1.29, 95% CI 1.09-1.54) and early onset (OR 1.71, 95% CI 1.20-2.43) preeclampsia, with results consistent across all noise indicators. The associations were much weaker or absent for mild and late preeclampsia. Environmental noise pollution may be a novel risk factor for pregnancy-related hypertension, particularly more severe variants of preeclampsia. Copyright © 2018 Elsevier Ltd. All rights reserved.

  1. The role of selenium in predicting preeclampsia

    Directory of Open Access Journals (Sweden)

    Z Ghaemi

    2013-10-01

    Full Text Available Introduction: Preeclampsia is a common disorder that is a leading cause of perinatal and maternal morbidity and mortality; however its specific etiology has still remained obscure.The first step in preventing preeclampsia is early detection of women at risk. Since there is no valid and reliable screening test, appropriate diagnostic and screening tests are necessary, which are inexpensive, non-invasive and beneficial for pregnant women. Therefore, regarding the role of selenium as an antioxidant in the prevention preeclampsia, this study was designed which aimed to determine the prognostic value of plasma selenium levels in the diagnosis of preeclampsia in primigravida women Methods: In a nested case control design, a sample of 650 normal primigravida women of 24-28 weeks participated in the study. Subjects who involved the case group were followed up for 3 months and 38 were affected by preeclampsia. Blood samples were obtained from these 38patients as well as from 38 subjects as their matched controls. Moreover, the amount of selenium was measured by atomic absorption spectrometry. Results: The mean level of selenium in blood plasma of the cases was significantly lower than in their matched controls. The present study findings revealed that pregnant women with serum Se < 66.1 μg/L had a significantly increased risk of preeclampsia. Conclusion: Lower plasma selenium level in women destines to suffering from preeclampsia which confirms the destructive effect of selenium deficiency as an antioxidant in etiopathology of preeclampsia. Measurement of plasma selenium can improve the prediction of preeclampsia; thus, it seems that plasma selenium level test owns an acceptable sensitivity and specificity for predicting preeclampsia.

  2. Estudio de intervención en gestantes sobre el conocimiento de las infecciones de transmisión sexual. Joyabaj Guatemala agosto 2010–enero 2011

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    Bárbara Teresa Calderón-Badía

    2013-01-01

    Full Text Available Se realizó una intervención educativa con el objetivo de aumentar los conocimientos que en relación a las infecciones de transmisión sexual (ITS posee un grupo de gestantes en el distrito de salud de Joyabaj, departamento de Quiché durante los meses de agosto de 2010 a enero de 2011. En las pacientes estudiadas predominó la vulvovaginitis por Candida (69.2%, Trichomoniasis (23% y con dilomas (19.1%. Antes de la intervención educativa el 73% de las gestantes no identificó adecuadamente las ITS, el 76.9% no conocía las principales formas de prevención, el 80.7% desconocía el uso adecuado del preservativo como medio de protección, el 50% se informó sobre el tema por medio de amigos. Posterior a la realización de la capacitación se lograron altos niveles de conocimientos sobre los temas evaluados y el 100% de las participantes consideró de gran utilidad el programa para su aprendizaje.

  3. ENTRE DESEJOS E POSSIBILIDADES: PRÁTICAS ALIMENTARES DE GESTANTES EM UMA COMUNIDADE URBANA NO SUL DO BRASIL

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    Carolina Frescura Junges

    2014-01-01

    Full Text Available estudio cualitativo, cuyo objetivo fue comprender las prácticas alimentarias de embarazadas que viven en una comunidad urbana al sur de Brasil. El método adoptó el abordaje de la etnoenfermería y la recolección de datos ocurrió a partir de un guión habilitador Observación-Participación-Reflexión, con cuatro embarazadas. El análisis etnográfico fue realizado en concomitancia con la recolección de datos, buscando temas que mantuvieran las interrogaciones de investigación. Los resultados permitieron revelar los significados culturales que las embarazadas atribuyeron a los saberes y a las prácticas alimentares, destacando las influencias de historia familiar y las relaciones sociales existentes en la comunidad. La percepción de los cambios corporales bajo la óptica de las embarazadas está relacionada a las elecciones alimentarias. Los profesionales enfermeros que ayuden a las embarazadas, al valorar las dimensiones del cuidado cultural, se aproximan de la familia y la comunidad, permitiendo una mejor adhesión al pre natal y promocionando acciones educativas coherentes con la cultura de estas gestantes.

  4. Indicación temprana de electroforesis de hemoglobina a gestantes de Ciudad de La Habana

    Directory of Open Access Journals (Sweden)

    Marcos Raúl Martín Ruiz

    2000-06-01

    Full Text Available Con el propósito de lograr la detección temprana de parejas de alto riesgo de tener hijos con anemia falciforme en una edad gestacional lo más temprana posible, se estableció en el sistema nacional de salud en 1991-92 que el pesquisaje de hemoglobinas anormales en gestantes se hiciera en la captación del embarazo. Para evaluar la medida se consideraron 9 424 indicaciones de 80 áreas de salud de Ciudad de La Habana en 1999, con un 86,5 % de indicaciones tempranas globalmente, mientras que en 1992 fue 46,4 %. En la distribución de áreas de salud por intervalos según porcentaje de indicación temprana, se encontró: 75 al 84 %: 26 áreas de salud (32,5 %; 85-89 %: 29 (36,3 %; 90-94 %: 25 (31,3 %; y 95 % y más: ninguno. Se muestra en los resultados una notable mejoría en el cumplimiento de la medida. Todavía es necesario mejorar la divulgación y principalmente en áreas de salud todavía con insuficiencias.In order to detect as early as possible those couples at high risk for having children with sickle cell anemia, it was established in the national health system in l991-92 that the screening of abnormal hemoglobins in pregnant women should be made at the time of catchment. To evaluate the measure 9 424 indications of 80 health areas in Havana City were evaluated in l999, with 86,5% of early indications, whereas in l992 it was 46,4%. In the distribution of health areas by intervals according to the percentage of early indication the following results were obtained: 75-84%: 26 health areas (32,5%; 85-89%: 29 (36,3%; 90-94%: 25 (31,3% and 95% and over: none. It is observed a significant improvement concerning the fulfillment of this measure. It is still necessary to enhance spreading, mainly in those health areas with deficiencies

  5. Preeclampsia as the great impostor.

    Science.gov (United States)

    Goodlin, R C

    1991-06-01

    In contrast with a generation ago when preeclampsia was misdiagnosed as medical or surgical disease unrelated to pregnancy, today's diagnostic errors are those that consider surgical and medical problems as either pregnancy-induced hypertension or as the hemolysis, elevated liver enzymes, and low platelet count syndrome. Eleven case histories are presented of significant medical or surgical problems that were initially diagnosed as hemolysis, elevated liver enzymes, and low platelet count syndrome or pregnancy-induced hypertension. The incorrect diagnosis of medical-surgical cases during pregnancy often meant that appropriate therapy was delayed and that the rate of iatrogenic prematurity was increased.

  6. Prevención de la transmisión materno-infantil del VIH en gestantes y madres awajún y wampis de la región Amazonas en Perú

    OpenAIRE

    Huamán, Byelca; Gushiken, Alfonso; Benites, Carlos; Quiroz, Fabiola; García-Fernández, Lisset

    2017-01-01

    Objetivos. Identificar las barreras que limitan el cumplimiento de las medidas de prevención de la transmisión materno-infantil (TMI) del VIH, en comunidades indígenas de la región Amazonas en Perú. Materiales y métodos. Investigación cualitativa con enfoque fenomenológico. Se realizaron entrevistas semiestructuradas a gestantes y madres de niños menores de un año de las comunidades indígenas awajún y wampis diagnosticadas con VIH durante el 2014-2015. Resultados. Participaron 15 de 29 mujere...

  7. Prevención de la transmisión materno-infantil del VIH en gestantes y madres awajún y wampis de la región Amazonas en Perú

    OpenAIRE

    Huamán, Byelca; Estrategia Sanitaria de Prevención y Control de ITS, VIH/SIDA y hepatitis B. Ministerio de Salud. Lima, Perú. Licenciada, magíster en Epidemiología; Gushiken, Alfonso; Instituto Nacional de Salud. Lima, Perú. médico, magíster en salud pública; Benites, Carlos; Hospital Nacional Arzobispo Loayza. Lima, Perú. médico cirujano; Quiroz, Fabiola; UNICEF, Perú. licenciado magíster en salud pública; García-Fernández, Lisset; Estrategia Sanitaria de Prevención y Control de ITS, VIH/SIDA y hepatitis B. Ministerio de Salud. Lima, Perú. médico, magíster en salud pública

    2017-01-01

    RESUMEN Objetivos Identificar las barreras que limitan el cumplimiento de las medidas de prevención de la transmisión materno-infantil (TMI) del VIH, en comunidades indígenas de la región Amazonas en Perú. Materiales y métodos Investigación cualitativa con enfoque fenomenológico. Se realizaron entrevistas semiestructuradas a gestantes y madres de niños menores de un año de las comunidades indígenas awajún y wampis diagnosticadas con VIH durante el 2014-2015. Resultados Participaron 15 d...

  8. Significado da presença de esquizócitos no sangue periférico de gestantes com pré-eclâmpsia Ming of the presence of schistocytes in blood smear of preeclamptic pregnat women

    Directory of Open Access Journals (Sweden)

    Rosângela de Fátima do Nascimento e Silva

    2008-08-01

    Full Text Available OBJETIVO: avaliar o significado da presença de esquizócitos em esfregaço de sangue periférico de gestantes com pré-eclâmpsia, identificando-os e correlacionando-os com outros marcadores de hemólise e da gravidade da doença. MÉTODOS: foram avaliadas 76 lâminas de esfregaço de sangue periférico de gestantes portadoras de pré-eclâmpsia. Após a realização do esfregaço, as lâminas foram submetidas ao corante de Leishman e armazenadas até a leitura, feita em microscópio modelo DLMB, da marca Leica, com aumento de 40 vezes e imersão em óleo. O microscópio era dotado de software Qwin Lite 2.5, que permitia gravar as imagens dos campos escolhidos em CD-ROM. Em cada lâmina foram contados dez campos com aproximadamente 100 eritrócitos. Foi considerada presença de esquizócitos (fragmento irregular ou em forma de capacete, de mordida ou triângulo quando a porcentagem dos mesmos era maior ou igual que 0,2%. A presença de esquizócitos foi correlacionada com outros marcadores de hemólise (hemoglobina, bilirrubina total, desidrogenase lática e reticulócitos, marcadores da pré-eclâmpsia (proteinúria e número de plaquetas e com a gravidade da pré-eclâmpsia. Para análise estatística foi utilizado o programa Statistical Package in Social Science (SPSS, versão 10.0, com valor de pPURPOSE: to evaluate the significance of schizocytes presence in peripheral blood smear of pregnant women with pre-eclampsia, identifying and correlating them with other markers of hemolysis and of the disease severity. METHODS: Seventh six glass slides of peripheral blood smear of pregnant women with pre-eclampsia have been evaluated. After the smear, the slides have been stained with Leishman's dye and stored till they were examined with a Leica, model DLMB microscope, provided with the Qwin Lite 2.5 software that made it possible to record the images of selected fields in CD-ROM. Ten fields with approximately 100 erythrocytes were counted in each

  9. Animal models of preeclampsia; uses and limitations.

    LENUS (Irish Health Repository)

    McCarthy, F P

    2012-01-31

    Preeclampsia remains a leading cause of maternal and fetal morbidity and mortality and has an unknown etiology. The limited progress made regarding new treatments to reduce the incidence and severity of preeclampsia has been attributed to the difficulties faced in the development of suitable animal models for the mechanistic research of this disease. In addition, animal models need hypotheses on which to be based and the slow development of testable hypotheses has also contributed to this poor progress. The past decade has seen significant advances in our understanding of preeclampsia and the development of viable reproducible animal models has contributed significantly to these advances. Although many of these models have features of preeclampsia, they are still poor overall models of the human disease and limited due to lack of reproducibility and because they do not include the complete spectrum of pathophysiological changes associated with preeclampsia. This review aims to provide a succinct and comprehensive assessment of current animal models of preeclampsia, their uses and limitations with particular attention paid to the best validated and most comprehensive models, in addition to those models which have been utilized to investigate potential therapeutic interventions for the treatment or prevention of preeclampsia.

  10. Maternal Periodontitis, Preeclampsia and Adverse Pregnancy Outcomes

    Directory of Open Access Journals (Sweden)

    Pourandokht Afshari

    2013-07-01

    Full Text Available Background and Aim: Preeclampsia is a considerable problem of pregnancy. Endothelial dysfunction and placental hypoxia are the current hypothesis of preeclampsia. Chronic inflammation, including periodontitis may provoke systemic maternal and placental pro-inflammatory endothelial dysfunction, which represent a significant risk factor for diseases of vascular origin. So this study was carried out to evaluate the possible relationship between periodontitis and preeclampsia. Methods: A total of 360 pregnant women were included, corresponding to 180 pregnant women with mild or sever periodotitis in one group and 180 pregnant women with periodontal health in the other group. Periodontitis was determined by the sum of all pockets with pocket probing depth (PPD ≥4mm and bleeding on probing. periodontal health was defined as the absence of PPD≥ 4mm. Then two groups evaluated to determine the presence of preeclampsia. After delivery, Child weight at birth and gestational age was also evaluated. Chi square and t test analysis were used to analyze the data. Results: There was statistically significant difference between two groups in presence of preeclampsia (p=0.003. Women who had a worse periodontal condition were at higher risk for preeclampsia. In addition, birth weight and gestational age was statistically lower in the case group than the control group (p < 0.001. Conclusion: The results indicate that the presence and severity of peridontitis increase the risk for occurrence of preeclampsia and adverse pregnancy outcomes.

  11. La aspirina es ineficaz en la prevención de la pre-eclampsia

    Directory of Open Access Journals (Sweden)

    Carlos Bustamante Rojas

    1998-10-01

    Full Text Available Tres recientes estudios han confirmado que la aspirina no aporta ningún beneficio en la prevención de la pre-eclampsia o en reducir los efectos de esta en los recién nacidos. Sin embargo, y a pesar de la evidencia cada vez mayor de ineficacia, muchos continúan usándola de rutina con este fin. EI resultado de un primer ensayo clínico aleatorizado con 2.539 mujeres en alto riesgo para presentar pre-eclampsia, llevado a cabo en el National Institute of Child Health and Human Development en los Estados Unidos, demostró categóricamente que el tratamiento preventivo con aspirina no sirve; las diferencias halladas frente al placebo no fueron estadísticamente significativas, tomando para el estudio mujeres con diabetes previa, hipertensión arterial, o antecedentes de pre-eclampsia. Tampoco hubo ninguna diferencia en cuanto al número de partos pretérmino, bajo peso para la edad gestacional y mortalidad.

  12. Transmissão vertical do HIV: expectativas e ações da gestante soropositiva Transmisión vertical del VHI: expectativas y acciones de la gestante seropositiva HIV perinatal transmission: expectations and actions of hiv-positive pregnant women

    Directory of Open Access Journals (Sweden)

    Edilene Lins de Moura

    2006-06-01

    Full Text Available Este estudo descritivo, com abordagem qualitativa, foi motivado pelo elevado número de casos de transmissão vertical do HIV. Teve como objetivo identificar as expectativas e ações da gestante HIV positivo quanto à gravidez e ao concepto. A amostra constituiu-se de 14 gestantes infectadas, assintomáticas, que conheciam sua soropositividade antes da gravidez e que estavam no 3º trimestre de gestação. Utilizou-se entrevista para a coleta de dados que ocorreu em 2001 e 2002. Empregou-se o Método do Discurso do Sujeito Coletivo para analisar os dados. Verificou-se que, quanto à maternidade, as gestantes tinham expectativas semelhantes, adaptaram-se à gravidez, e acreditavam na soronegatividade do bebê e na efetividade do tratamento. Concluiu-se pela necessidade de implementação de orientação para a saúde direcionada à mulher com enfoque na transmissão vertical do HIV/aids.Este estudio descriptivo, con aproximación cualitativa, fue motivado por el gran número de niños con transmisión vertical del VHI. Tuvo como objetivo identificar las expectativas y acciones de la gestante VHI positivo en cuanto al embarazo y al concepto. La muestra se constituyó de 14 gestantes infectadas, asintomáticas, que conocían su seropositividad antes del embarazo y que estaban en el 3.er trimestre de gestación. Para la recolección de los datos, realizada en el período de 2001 y 2002, se utilizó la entrevista. El Método de Discurso de Sujeto Colectivo fue empleado para analizar los datos. Se verificó que, en cuanto a la maternidad, las gestantes tenían expectativas semejantes. Se adaptaron a la gestación, confiaban en que el bebé seria suero negativo y en la efectividad del tratamiento realizado. Las conclusiones orientan hacia la necesidad de implementación de orientación sobre la salud de la mujer con acercamiento en la transmisión vertical del VHI/SIDA.This descriptive study with a qualitative approach was motivated by the high number

  13. gross morphological study of placenta in preeclampsia

    African Journals Online (AJOL)

    2017-06-12

    Jun 12, 2017 ... A cross-sectional study was carried out on preeclampsia mothers who gave birth at ... maternal and fetal surfaces (Ashfaq, Janjua, and. Channa, 2005). A term .... causing loss and fibrosis of parenchyma tissue. These changes ...

  14. Preeclampsia As Modulator of Offspring Health

    NARCIS (Netherlands)

    Stojanovska, Violeta; Scherjon, Sicco A; Plösch, Torsten

    2016-01-01

    A balanced intrauterine homeostasis during pregnancy is crucial for optimal growth and development of the fetus. The intrauterine environment is extremely vulnerable to multisystem pregnancy disorders such as preeclampsia, which can be triggered by various pathophysiological factors, such as

  15. A Historical Overview of Preeclampsia-Eclampsia

    OpenAIRE

    Bell, Mandy J.

    2010-01-01

    Preeclampsia is a hypertensive, multi-system disorder of pregnancy whose etiology remains unknown. Although management is evidence-based, preventative measures/screening tools are lacking, treatment remains symptomatic, and delivery remains the only cure. Past hypotheses/scientific contributions have influenced current understanding of preeclampsia pathophysiology and guided management strategies and classification criteria. To provide insight into how past hypotheses/scientific contributions...

  16. Protein Profiling of Preeclampsia Placental Tissues

    OpenAIRE

    Shu, Chang; Liu, Zitao; Cui, Lifeng; Wei, Chengguo; Wang, Shuwen; Tang, Jian Jenny; Cui, Miao; Lian, Guodong; Li, Wei; Liu, Xiufen; Xu, Hongmei; Jiang, Jing; Lee, Peng; Zhang, David Y.; He, Jin

    2014-01-01

    Preeclampsia is a multi-system disorder involved in pregnancy without an effective treatment except delivery. The precise pathogenesis of this complicated disorder is still not completely understood. The objective of this study is to evaluate the alterations of protein expression and phosphorylations that are important in regulating placental cell function in preterm and term preeclampsia. Using the Protein Pathway Array, 38 proteins in placental tissues were found to be differentially expres...

  17. DNA Methylation as a Biomarker for Preeclampsia

    Energy Technology Data Exchange (ETDEWEB)

    Anderson, Cindy M.; Ralph, Jody L.; Wright, Michelle L.; Linggi, Bryan E.; Ohm, Joyce E.

    2014-10-01

    Background: Preeclampsia contributes significantly to pregnancy-associated morbidity and mortality as well as future risk of cardiovascular disease in mother and offspring, and preeclampsia in offspring. The lack of reliable methods for early detection limits the opportunities for prevention, diagnosis, and timely treatment. Purpose: The purpose of this study was to explore distinct DNA methylation patterns associated with preeclampsia in both maternal cells and fetal-derived tissue that represent potential biomarkers to predict future preeclampsia and inheritance in children. Method: A convenience sample of nulliparous women (N = 55) in the first trimester of pregnancy was recruited for this prospective study. Genome-wide DNA methylation was quantified in first-trimester maternal peripheral white blood cells and placental chorionic tissue from normotensive women and those with preeclampsia (n = 6/group). Results: Late-onset preeclampsia developed in 12.7% of women. Significant differences in DNA methylation were identified in 207 individual linked cytosine and guanine (CpG) sites in maternal white blood cells collected in the first trimester (132 sites with gain and 75 sites with loss of methylation), which were common to approximately 75% of the differentially methylated CpG sites identified in chorionic tissue of fetal origin. Conclusion: This study is the first to identify maternal epigenetic targets and common targets in fetal-derived tissue that represent putative biomarkers for early detection and heritable risk of preeclampsia. Findings may pave the way for diagnosis of preeclampsia prior to its clinical presentation and acute damaging effects, and the potential for prevention of the detrimental long-term sequelae.

  18. Decreased maternal plasma apelin concentrations in preeclampsia.

    Science.gov (United States)

    Bortoff, Katherine D; Qiu, Chunfang; Runyon, Scott; Williams, Michelle A; Maitra, Rangan

    2012-01-01

    Preeclampsia is a hypertensive disorder that complicates 3-7% of pregnancies. The development of preeclampsia has not been completely elucidated and current therapies are not broadly efficacious. The apelinergic system appears to be involved in hypertensive disorders and experimental studies indicate a role of this system in preeclampsia. Thus, an epidemiological evaluation of apelin protein concentration in plasma was conducted in case-control study of pregnant women. Data and maternal plasma samples were collected from pregnant women with confirmed preeclampsia (n = 76) or normotensive controls (n = 79). Concentrations of apelin peptides were blindly measured using enzyme-linked immunosorbent assay. Data were subjected to statistical analyses. Plasma apelin concentrations, measured at delivery, were lower in preeclampsia cases compared with controls (mean ± standard deviation: 0.66 ± 0.29 vs. 0.78 ± 0.31 ng/mL, p = 0.02). After controlling for confounding by maternal age, smoking status, and pre-pregnancy body mass index, odds of preeclampsia were 48% lower for women with high versus low plasma apelin (≥0.73 vs. preclampsia and other hypertensive maternal disorders.

  19. RELATION BETWEEN PREECLAMPSIA AND CARDIAC ENZYMES

    Directory of Open Access Journals (Sweden)

    Rubina Aziz

    2010-12-01

    Full Text Available Abstract    INTRODUCTION: Preeclampsia affects about 5-10% of all pregnancies and is a major cause of maternal, fetal and neonatal mortality and morbidity. The cardiovascular system undergoes a host of changes in association with development of preeclampsia. LDH is a useful biochemical marker that reflects the severity of the occurrence of preeclampsia.    METHOD AND MATERIALS: One hundred pregnant women were selected for this study, 50 normal pregnant women as controls and 50 preeclamptic women as the study group.  Cardiac enzymes (serum LDH, serum AST, serum CK and serum CKMB of these women were analyzed.    RESULTS: Mean Serum LDH and mean serum AST concentrations were significantly higher in preeclamptic patients compared to normal pregnant women (348.34 ± 59.17 vs. 255.92 ± 43.26, P < 0.01 and (34.32 ± 10.37 vs. 22.06 ± 5.10, P < 0.01 respectively.     CONCLUSION: LDH and AST may be increased due to liver damage. This endothelial vascular damage is the main cause in the occurrence of preeclampsia. Higher levels of LDH and AST are very useful markers to identify the occurrence of preeclampsia.      Keywords: LDH, Preeclampsia, AST, Cardiac Enzymes.

  20. Preeclampsia: Updates in Pathogenesis, Definitions, and Guidelines.

    Science.gov (United States)

    Phipps, Elizabeth; Prasanna, Devika; Brima, Wunnie; Jim, Belinda

    2016-06-06

    Preeclampsia is becoming an increasingly common diagnosis in the developed world and remains a high cause of maternal and fetal morbidity and mortality in the developing world. Delay in childbearing in the developed world feeds into the risk factors associated with preeclampsia, which include older maternal age, obesity, and/or vascular diseases. Inadequate prenatal care partially explains the persistent high prevalence in the developing world. In this review, we begin by presenting the most recent concepts in the pathogenesis of preeclampsia. Upstream triggers of the well described angiogenic pathways, such as the heme oxygenase and hydrogen sulfide pathways, as well as the roles of autoantibodies, misfolded proteins, nitric oxide, and oxidative stress will be described. We also detail updated definitions, classification schema, and treatment targets of hypertensive disorders of pregnancy put forth by obstetric and hypertensive societies throughout the world. The shift has been made to view preeclampsia as a systemic disease with widespread endothelial damage and the potential to affect future cardiovascular diseases rather than a self-limited occurrence. At the very least, we now know that preeclampsia does not end with delivery of the placenta. We conclude by summarizing the latest strategies for prevention and treatment of preeclampsia. A better understanding of this entity will help in the care of at-risk women before delivery and for decades after. Copyright © 2016 by the American Society of Nephrology.

  1. Preeclampsia and risk for epilepsy in offspring

    DEFF Research Database (Denmark)

    Wu, Chunsen; Sun, Yuelian; Vestergaard, Mogens

    2008-01-01

    OBJECTIVE: Eclampsia has been found to be a strong risk factor for epilepsy in the offspring, but it is unclear whether the risk also applies to the preceding condition, preeclampsia. METHODS: We conducted a population-based cohort study of 1537860 singletons born in Denmark (1978-2004). Informat......OBJECTIVE: Eclampsia has been found to be a strong risk factor for epilepsy in the offspring, but it is unclear whether the risk also applies to the preceding condition, preeclampsia. METHODS: We conducted a population-based cohort study of 1537860 singletons born in Denmark (1978......-2004). Information on preeclampsia (mild, severe, and unspecified), eclampsia, and epilepsy was obtained from the Danish National Hospital Register. Information on gestational age, birth weight, and Apgar score was obtained from the Danish Medical Birth Registry. We used Cox proportional hazard models to estimate...... the incidence rate ratio of epilepsy for children who were exposed to preeclampsia or eclampsia in prenatal life. RESULTS: We identified 45288 (2.9%) children who were exposed to preeclampsia (34823 to mild, 7043 to severe, and 3422 to unspecified preeclampsia) and 654 (0.04%) to eclampsia during their prenatal...

  2. Innate immune system and preeclampsia

    Directory of Open Access Journals (Sweden)

    Alejandra ePerez-Sepulveda

    2014-05-01

    Full Text Available Normal pregnancy is considered as a Th2 type immunological state that favors an immune-tolerance environment in order to prevent fetal rejection. PE has been classically described as a Th1/Th2 imbalance; however, the Th1/Th2 paradigm has proven insufficient to fully explain the functional and molecular changes observed during normal/pathological pregnancies. Recent studies have expanded the Th1/Th2 into a Th1⁄Th2⁄Th17 and regulatory T (Treg cells paradigm and where dendritic cells could have a crucial role. Recently, some evidence has emerged supporting the idea that mesenchymal stem cells might be part of the feto-maternal tolerance environment. This review will discuss the involvement of the innate immune system in the establishment of a physiological environment that favors pregnancy and possible alterations related to the development of preeclampsia.

  3. Hemostasis in pre-eclampsia.

    LENUS (Irish Health Repository)

    Ismail, Siti Khadijah

    2012-01-31

    Pre-eclampsia (P-EC) is a multisystem disorder exclusive to pregnancy. It complicates ~2 to 8% of all pregnancies and remains a major cause of maternal mortality. P-EC is characterized by a profound hypercoagulable state. The delicate hemostatic balance that must be maintained in the uteroplacental circulation during pregnancy makes this system vulnerable to perturbation. An abnormal hemostatic pattern occurs within the uteroplacental circulation in P-EC compared with normal pregnancy. Much recent research has focused on the epidemiological link between inherited thrombophilia and P-EC. The data suggest a weak statistical association, indicating an improbable primary role in the pathogenesis. Without clear evidence, low molecular weight heparins have been widely used to reduce recurrence of P-EC in thrombophilia-positive women. This practice now should be reviewed. Future research needs to focus on improving our basic scientific understanding of the role of the hemostatic system in human placentation.

  4. Hemostasis in pre-eclampsia.

    LENUS (Irish Health Repository)

    Ismail, Siti Khadijah

    2011-03-01

    Pre-eclampsia (P-EC) is a multisystem disorder exclusive to pregnancy. It complicates ~2 to 8% of all pregnancies and remains a major cause of maternal mortality. P-EC is characterized by a profound hypercoagulable state. The delicate hemostatic balance that must be maintained in the uteroplacental circulation during pregnancy makes this system vulnerable to perturbation. An abnormal hemostatic pattern occurs within the uteroplacental circulation in P-EC compared with normal pregnancy. Much recent research has focused on the epidemiological link between inherited thrombophilia and P-EC. The data suggest a weak statistical association, indicating an improbable primary role in the pathogenesis. Without clear evidence, low molecular weight heparins have been widely used to reduce recurrence of P-EC in thrombophilia-positive women. This practice now should be reviewed. Future research needs to focus on improving our basic scientific understanding of the role of the hemostatic system in human placentation.

  5. Impacto de la aplicación de los criterios de la asociación americana de tiroides en el diagnóstico de hipotiroidismo en gestantes de Vigo, España

    Directory of Open Access Journals (Sweden)

    Marta Pombar-Pérez

    Full Text Available Con el objetivo de determinar el impacto de la aplicación de los criterios de la Asociación Americana de Tiroides (ATA en el diagnóstico de hipotiroidismo en gestantes del área sanitaria de Vigo en España, se analizó la concentración sérica de tirotropina (TSH, tiroxina libre (T4L y anticuerpos antitiroideos, comparando la frecuencia de gestantes diagnosticadas de hipotiroidismo aplicando los criterios utilizados en el laboratorio de hormonas del Hospital Xeral y los criterios de referencia propuestos por la ATA. La asunción de dichos criterios implicaría un aumento de un 29,6% de pacientes diagnosticadas de hipotiroidismo. La aplicación de los criterios ATA tuvo una repercusión en la medición de la concentración de TSH en gestantes lo que sugiere una evaluación de los valores de referencia de TSH en función de la población y los métodos de diagnóstico locales

  6. Impacto de la aplicación de los criterios de la asociación americana de tiroides en el diagnóstico de hipotiroidismo en gestantes de Vigo, España

    Directory of Open Access Journals (Sweden)

    Marta Pombar-Pérez

    2013-07-01

    Full Text Available Con el objetivo de determinar el impacto de la aplicación de los criterios de la Asociación Americana de Tiroides (ATA en el diagnóstico de hipotiroidismo en gestantes del área sanitaria de Vigo en España, se analizó la concentración sérica de tirotropina (TSH, tiroxina libre (T4L y anticuerpos antitiroideos, comparando la frecuencia de gestantes diagnosticadas de hipotiroidismo aplicando los criterios utilizados en el laboratorio de hormonas del Hospital Xeral y los criterios de referencia propuestos por la ATA. La asunción de dichos criterios implicaría un aumento de un 29,6% de pacientes diagnosticadas de hipotiroidismo. La aplicación de los criterios ATA tuvo una repercusión en la medición de la concentración de TSH en gestantes lo que sugiere una evaluación de los valores de referencia de TSH en función de la población y los métodos de diagnóstico locales

  7. Prevalência do uso de drogas de abuso por gestantes

    OpenAIRE

    Kassada,Danielle Satie; Marcon,Sonia Silva; Pagliarini,Maria Angélica; Rossi,Robson Marcelo

    2013-01-01

    OBJETIVO: Determinar a prevalência do uso de drogas de abuso por gestantes. MÉTODO: Estudo transversal que incluiu 394 gestantes usuárias de serviço de atenção primária. A variável dependente foi o uso de drogas de abuso durante a gestação e as variáveis independentes foram: socioeconômicas e obstétricas. RESULTADOS: A prevalência do uso de drogas ilícitas entre gestantes foi de 18,28%. A regressão logística multivariada indicou como variáveis significativas: anos de estudo, participação em g...

  8. La alimentación de la gestante adolescente: el cambio favorable Diet of the pregnant adolescent: the favorable change A alimentação da gestante adolescente: o câmbio favorável

    Directory of Open Access Journals (Sweden)

    BERNAL ROLDÁN MARÍA CARMEN

    2010-04-01

    Full Text Available El presente estudio de tipo cualitativo y etnográfico de pequeño alcance, tiene como objetivo describir el significado del cuidado de sí de un grupo de gestantes adolescentes y su hijo por nacer, con relación a la alimentación, a partir de sus prácticas, creencias y valores culturales, quienes asistieron a control prenatal a la Unidad de Atención Primaria (UPA de Candelaria la Nueva, Hospital Vista Hermosa, Ciudad Bolívar, Localidad 19 de Bogotá, en 2007. La información fue aportada por ocho adolescentes primigestantes de entre 17 y 19 años de edad, que estaban entre el cuarto y séptimo meses de gestación, sin patologías asociadas, que asistieron al primer control prenatal, seleccionadas intencionalmente y que estuvieron dispuestas a participar de la investigación (previo consentimiento informado. La recolección de datos se realizó a través de la entrevista etnográfica no estructurada; se obtuvo como resultado el significado del cuidado en las gestantes adolescentes y se aportaron tres grandes beneficios positivos del cuidado de la alimentación materna: cambio de hábito alimentario, alimentarse para proteger la salud del bebé y para que nazca sano, y alimentarse para proteger la salud de la madre adolescente. Dichos resultados, conjugados en el escenario cultural de las gestantes adolescentes, permiten explorar y conocer cómo se cuidan ellas a través de las prácticas soportadas en el saber como conocimiento y razón, y el uso como los artefactos que utiliza.The purpose of this limited scope, qualitative and ethnographic study is to describe the meaning of self-care for a group of pregnant adolescents and their unborn child, in relation to their diet, based on their practices, beliefs and cultural values, and who attended a prenatal checkup at the Primary Care Unit (UPA of Candelaria la Nueva, Vista Hermosa Hospital, Ciudad Bolívar, District number 19 de Bogotá, in 2007. The information contributed by eight first

  9. La alimentación de la gestante adolescente: el cambio favorable A alimentação da gestante adolescente: o câmbiofavorável Diet of the pregnant adolescent: the favorable change

    Directory of Open Access Journals (Sweden)

    ISABEL RODRÍGUEZ HERNÁNDEZ

    2010-06-01

    Full Text Available El presente estudio de tipo cualitativo y etnográfico de pequeño alcance, tiene como objetivo describir el significado del cuidado de sí de un grupo de gestantes adolescentes y su hijo por nacer, con relación a la alimentación, a partir de sus prácticas, creencias y valores culturales, quienes asistieron a control prenatal a la Unidad de Atención Primaria (UPA de Candelaria la Nueva, Hospital Vista Hermosa, Ciudad Bolívar, Localidad 19 de Bogotá, en 2007. La información fue aportada por ocho adolescentes primigestantes de entre 17 y 19 años de edad, que estaban entre el cuarto y séptimo meses de gestación, sin patologías asociadas, que asistieron al primer control prenatal, seleccionadas intencionalmente y que estuvieron dispuestas a participar de la investigación (previo consentimiento informado. La recolección de datos se realizó a través de la entrevista etnográfica no estructurada; se obtuvo como resultado el significado del cuidado en las gestantes adolescentes y se aportaron tres grandes beneficios positivos del cuidado de la alimentación materna: cambio de hábito alimentario, alimentarse para proteger la salud del bebé y para que nazca sano, y alimentarse para proteger la salud de la madre adolescente. Dichos resultados, conjugados en el escenario cultural de las gestantes adolescentes, permiten explorar y conocer cómo se cuidan ellas a través de las prácticas soportadas en el saber como conocimiento y razón, y el uso como los artefactos que utiliza.O presente trabalho de tipo qualitativo e etnográfico de curto alcance visa descrever o significado do cuidado próprio de um grupo de gestantes adolescentes e seu filho por nascer em termos de alimentação e com base em suas práticas, crenças e valores culturais, que estiveram em controle pré-natal na Unidade de Atenção Primária (UPA de Candelaria La Nueva, Hospital Vista Hermosa, Ciudad Bolívar, Localidade 19 de Bogotá em 2007. A informação foi fornecida

  10. Preeclampsia

    Science.gov (United States)

    ... relative • First pregnancy • Twin or triplet pregnancy • Advanced maternal age (>40 years) • Diabetes mellitus • Hypertension • Obesity • Antiphospholipid antibody syndrome What Signs and Symptoms Should ...

  11. Suicidio en mujeres gestantes: vivencias y redes de apoyo para las familias que les sobreviven

    Directory of Open Access Journals (Sweden)

    María V. Builes-Correa

    2014-09-01

    Full Text Available Resumen Objetivo: describir la vivencia que han tenido las familias de dos mujeres gestantes alrededor de su muerte por suicidio en el Departamento de Antioquia (Colombia durante el año 2010-2011. Metodología: investigación cualitativa, método fenomenológico-hermenéutico, específicamente estudio de casos. Se realizaron entre tres y cuatro entrevistas con cada familia y posteriormente se sistematizaron bajo el software Atlas ti. Resultados: en la familia de Bella se encontró la categoría: la vivencia familiar frente al suicidio: de cómo tornarse aprendiz; de ésta surgieron dos categorías: 1. Su muerte nos afectó por dentro y por fuera; 2. entre la sordera y la potencia de las redes de apoyo. En la familia de Consentida emerge la categoría la vivencia familiar: cómo sobrevivir al dolor, a su vez de ella se derivan dos tendencias: 1. Ampliando y rompiendo redes: 2. atando cabos. Conclusiones: las familias del estudio han ido sobreponiéndose al evento en tanto han logrado reconocimiento por parte de redes colaborativas, potenciadoras y vinculantes que han permanecido a lo largo del tiempo. En su vivencia las familias han logrado tomar distancia de la elección de sus familiares gestantes y han seguido valientemente sobreponiéndose a su pérdida. Abstract Objective: to describe the experiences of the families of two pregnant women who committed suicide in the Department of Antioquia (Colombia during 2010-2011. Methodology: a qualitative study using the hermeneutic phenomenological approach, specifically the case study method. Three to four interviews were conducted with each family. These interviews were later systematized using the Atlas ti software. Results: the category “family experience in the event of suicide: on how to become a learner” was found in the family of Bella, and two categories emerged from it: 1. “Her death affected us both internally and externally.” 2. “Between deafness and the power of the support

  12. Canto pré-natal: alquimias sonoras para gestantes

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    Janaina Trasel Martins

    2017-10-01

    Full Text Available Este artigo irá focar no canto pré-natal; nos benefícios da música e do canto durante a gestação; na audição do feto no ventre e na escuta da gestante do seu corpo. Como metodologia para pesquisar sobre estes temas foram realizados estudos teóricos nas áreas da musicoterapia obstétrica, da terapia sonora e da medicina e também foram realizadas práticas de canto pré-natal. Arte, movimento e saúde são integrados com as alquimias sonoras para ampliar a consciência da corporeidade da mulher durante a gestação. Com cantos femininos em um círculo de mulheres, nos apoiamos e nos fortalecemos durante a gestação e enviamos vibrações sonoras harmoniosas para o bebê no ventre. ABSTRACT This article will focus on prenatal singing; on the benefits of music and singing during pregnancy; on the baby's hearing in the womb and on the listening of the pregnant woman to her body. To determine the methodology for researching these themes, theoretical studies were done in obstetrical music therapy, sound therapy, medicine and also practical research in prenatal singing classes. Art, movement and health are integrated with sound alchemy to widen the woman’s body awareness during pregnancy. With feminine chants in a circle of women, we support and strengthen ourselves during pregnancy and we send harmonious sounds vibrations to the baby in the womb. KEYWORDS Prenatal singing, prenatal music, pregnancy, listening, consciousness.

  13. Baixa autoestima situacional em gestantes: uma análise de acurácia

    OpenAIRE

    Cavalcante, Joyce Carolle Bezerra; Sousa, Vanessa Emille Carvalho de; Lopes, Marcos Venícios de Oliveira

    2012-01-01

    Para investigar a acurácia de características definidoras do diagnóstico Baixa autoestima situacional, realizou-se um estudo transversal, com 52 gestantes atendidas num centro de atendimento familiar. Utilizou-se a taxonomia da NANDA-I e a escala de Rosenberg. O diagnóstico esteve presente em 32,7% das gestantes e todas as características apresentaram associação estatística com o diagnóstico, exceto "Relata verbalmente desafio situacional ao seu próprio valor". As características com maior se...

  14. Percepción de síntomas en primigestas con embarazo en vías de prolongación

    OpenAIRE

    Ana Belén López Araque; Manuel Linares Abad; Mª Dolores López Medina

    2015-01-01

    Durante el embarazo acontecen importantes cambios psicológicos, fisiológicos y socio-culturales que influyen en la gestante, la manera en la que ella vive esos cambios repercute de forma directa en su vivencia sobre la maternidad. Con el objetivo de conocer la percepción de síntomas presentes en la fase final del embarazo se llevó a cabo una investigación con metodología cualitativa de tipo fenomenológico, fundamentada en entrevistas individuales a siete gestantes en vías de prolongación que ...

  15. Lipid Peroxidation and Antioxidant Status in Preeclampsia

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    Rokeya Begum

    2011-07-01

    Full Text Available Background: Preeclampsia is the most common and major medical complication of pregnancy with a high incidence of maternal and foetal morbidity and mortality. During pregnancy abnormally increased lipid peroxidation and free radical formation as well as significantly decreased antioxidants production in maternal blood may lead to pathogenesis of preeclampsia. So, we designed this study as little information is known about lipid peroxidation and antioxidant level in preeclampsia. Objectives: To assess the serum malondialdehyde (MDA level as a lipid peroxidation product and vitamin E (antioxidant level in women with preeclampsia as well as in normal pregnancy and to compare the values. Materials and Methods: The study was conducted on 60 women aged from 25 to 35 years in the department of Biochemistry, Budi Kemuliaan Maternity Hospital (BKMH in Jakarta during the period April to July 2004. Twenty were normal pregnant women and 20 were preeclamptic patients. For comparison age matched 20 apparently healthy nonpregnant women were included in the study. The study subjects were selected from outpatient department (OPD of Obstetrics and Gynaecology of BKMH in Jakarta. Serum MDA (lipid peroxidation product level was measured by thiobarbituric acid reactive substances assay (TBRAS method and vitamin E was estimated spectroflurometrically. Data were analyzed by unpaired Student’s t test between the groups by using SPSS version 12. Results: The mean serum MDA levels were significantly higher in normal pregnancy and also in preeclampsia than that of nonpregnant control group women (p<0.001. Again the serum MDA levels were significantly higher in preeclampsia than that of normal pregnant women (p<0.001. The serum vitamin E levels were significantly lower in preeclampsia and also in normal pregnancy than that of nonpregnant control women (p<0.001. Moreover, the serum vitamin E levels were significantly lower in preeclampsia compared to that of normal

  16. Microorganismos patógenos y potencialmente patógenos en secreciones genitales de gestantes a término asociados a complicaciones posnatales

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    Tania Castellanos Medina

    2013-09-01

    Full Text Available Introducción: tanto las infecciones puerperales como las neonatales precoces reflejan probablemente los microorganismos que están presentes en la vagina en el período cercano al parto. Objetivo: establecer la relación entre los microorganismos identificados en las secreciones genitales de las gestantes a término y el desarrollo de sepsis neonatal y puerperal, así como vincular dichas complicaciones con los agentes diagnosticados. Métodos: se realizó un estudio longitudinal y prospectivo en los servicios de microbiología, obstetricia, perinatología y neonatología del Hospital General Docente "Dr. "Juan Bruno Zayas Alfonso", de Santiago de Cuba, desde julio de 2009 hasta marzo de 2010. Se identificaron microorganismos en 179 muestras cervicovaginales, las cuales fueron procesadas en el laboratorio de microbiología según las normas vigentes. Resultados: los microorganismos más identificados resultaron los géneros Mycoplasmas y Chlamydias (78,2 y 69,3%, respectivamente y fueron los que con mayor frecuencia se asociaron. Un porcentaje elevado de las gestantes (67,0 %, tenía más de un agente en sus secreciones genitales. Después del parto hubo un hallazgo mayor de infecciones en el producto de la concepción (21,8 % que en las puérperas (3,9% y la mayoría de estas complicaciones se relacionaron con la presencia de 2 o más microorganismos. Conclusiones: las asociaciones de microorganismos patógenos o potencialmente patógenos en las secreciones genitales de embarazadas a término, aumentan el riesgo de complicaciones posnatales.

  17. Preeclampsia and its interaction with common variants in thrombophilia genes

    NARCIS (Netherlands)

    de Maat, M. P. M.; Jansen, M. W. J. C.; Hille, E. T. M.; Vos, H. L.; Bloemenkamp, K. W. M.; Buitendijk, S.; Helmerhorst, F. M.; Wladimiroff, J. W.; Bertina, R. M.; de Groot, C. J. M.

    2004-01-01

    Recently, it has been proposed that abnormalities in coagulation and fibrinolysis contribute to the development of preeclampsia by increasing the thrombotic tendency. This hypothesis was tested in women who have had preeclampsia (cases) compared with matched controls. Polymorphisms in the

  18. Can serum free fatty acids assessment predict severe preeclampsia?

    African Journals Online (AJOL)

    Nermeen Saad El Beltagy

    2011-10-20

    Oct 20, 2011 ... Methods: Twenty cases with severe preeclampsia (blood pressure P 160/110 after 20th week of ges- tation and ... ing factor with preeclampsia in non-obese pregnant women. ... Preeclampsia (PE) is a common pregnancy disorder that is ... centration of free fatty acids in the serum was measured by an.

  19. Molecular genetics of preeclampsia and HELLP syndrome - A review

    NARCIS (Netherlands)

    Jebbink, Jiska; Wolters, Astrid; Fernando, Febilla; Afink, Gijs; van der Post, Joris; Ris-Stalpers, Carrie

    2012-01-01

    Preeclampsia is characterised by new onset hypertension and proteinuria and is a major obstetrical problem for both mother and foetus. Haemolysis elevated liver enzymes and low platelets (HELLP) syndrome is an obstetrical emergency and most cases occur in the presence of preeclampsia. Preeclampsia

  20. Endothelial and trophoblast (dys)function in preeclampsia

    NARCIS (Netherlands)

    Donker, Rogier Bertrand

    2007-01-01

    As described in chapter 1, preeclampsia is a serious complication of pregnancy and worldwide one of the major causes of maternal and fetal morbidity and mortality. In severe, early-onset preeclampsia, i.e., placental preeclampsia, the syndrome originates from a hypoperfused and hypoxic placenta. One

  1. Associations of personal and family preeclampsia history with the risk of early-, intermediate- and late-onset preeclampsia.

    Science.gov (United States)

    Boyd, Heather A; Tahir, Hassaan; Wohlfahrt, Jan; Melbye, Mads

    2013-12-01

    Preeclampsia encompasses multiple conditions of varying severity. We examined the recurrence and familial aggregation of preeclampsia by timing of onset, which is a marker for severity. We ascertained personal and family histories of preeclampsia for women who delivered live singletons in Denmark in 1978-2008 (almost 1.4 million pregnancies). Using log-linear binomial regression, we estimated risk ratios for the associations between personal and family histories of preeclampsia and the risk of early-onset (before 34 weeks of gestation, which is typically the most severe), intermediate-onset (at 34-36 weeks of gestation), and late-onset (after 36 weeks of gestation) preeclampsia. Previous early-, intermediate-, or late-onset preeclampsia increased the risk of recurrent preeclampsia with the same timing of onset 25.2 times (95% confidence interval (CI): 21.8, 29.1), 19.7 times (95% CI: 17.0, 22.8), and 10.3 times (95% CI: 9.85, 10.9), respectively, compared with having no such history. Preeclampsia in a woman's family was associated with a 24%-163% increase in preeclampsia risk, with the strongest associations for early- and intermediate-onset preeclampsia in female relatives. Preeclampsia in the man's family did not affect a woman's risk of early-onset preeclampsia and was only weakly associated with her risks of intermediate- and late-onset preeclampsia. Early-onset preeclampsia appears to have the largest genetic component, whereas environmental factors likely contribute most to late-onset preeclampsia. The role of paternal genes in the etiology of preeclampsia appears to be limited.

  2. Risk factors and effective management of preeclampsia

    Directory of Open Access Journals (Sweden)

    English FA

    2015-03-01

    Full Text Available Fred A English,1 Louise C Kenny,1 Fergus P McCarthy1,2 1Irish Centre for Fetal and Neonatal Translational Research (INFANT, Department of Obstetrics and Gynaecology, University College Cork, Cork, Ireland; 2Women’s Health Academic Centre, King's Health Partners, St Thomas' Hospital, London, UK Abstract: Preeclampsia, a hypertensive disorder of pregnancy is estimated to complicate 2%–8% of pregnancies and remains a principal cause of maternal and fetal morbidity and mortality. Preeclampsia may present at any gestation but is more commonly encountered in the third trimester. Multiple risk factors have been documented, including: family history, nulliparity, egg donation, diabetes, and obesity. Significant progress has been made in developing tests to predict risk of preeclampsia in pregnancy, but these remain confined to clinical trial settings and center around measuring angiogenic profiles, including placental growth factor or newer tests involving metabolomics. Less progress has been made in developing new treatments and therapeutic targets, and aspirin remains one of the few agents shown to consistently reduce the risk of developing preeclampsia. This review serves to discuss recent advances in risk factor identification, prediction techniques, and management of preeclampsia in antenatal, intrapartum, and postnatal patients. Keywords: pregnancy, treatment, risk reduction, prediction

  3. Antioxidants for Preventing Preeclampsia: A Systematic Review

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    Adriana Magalhaes Ribeiro Salles

    2012-01-01

    Full Text Available Objective. To investigate the efficacy of antioxidants for preventing preeclampsia and other maternal and fetal complications among pregnant women with low, moderate, or high risk of preeclampsia. Methods. We searched MEDLINE, Embase, CENTRAL, mRCT, and other databases, with no language or publication restrictions. Two independent reviewers selected randomized controlled trials that evaluated the use of antioxidants versus placebo and extracted the relevant data. Relative risks (RRs and 95% confidence intervals (95% CIs were calculated. The data were compiled through the random effects model. Main Results. Fifteen studies were included (21,012 women and 21,647 fetuses. No statistically significant difference was found between women who received antioxidant treatment and women who received placebo for preeclampsia (RR =0.92; 95% CI: 0.82–1.04, severe preeclampsia (RR =1.03; 95% CI: 0.87–1.22, preterm birth (RR =1.03; 95% CI: 0.94–1.14, and small for gestational age <10th centile (RR =0.92; 95% CI: 0.80–1.05. Side effects were numerically more frequent in the antioxidants group compared to placebo, but without significant statistical difference (RR =1.24; 95% CI: 0.85–1.80. Conclusions. The available evidence reviewed does not support the use of antioxidants during pregnancy for the prevention of preeclampsia and other outcomes.

  4. Antioxidants for Preventing Preeclampsia: A Systematic Review

    Science.gov (United States)

    Salles, Adriana Magalhaes Ribeiro; Galvao, Tais Freire; Silva, Marcus Tolentino; Motta, Lucilia Casulari Domingues; Pereira, Mauricio Gomes

    2012-01-01

    Objective. To investigate the efficacy of antioxidants for preventing preeclampsia and other maternal and fetal complications among pregnant women with low, moderate, or high risk of preeclampsia. Methods. We searched MEDLINE, Embase, CENTRAL, mRCT, and other databases, with no language or publication restrictions. Two independent reviewers selected randomized controlled trials that evaluated the use of antioxidants versus placebo and extracted the relevant data. Relative risks (RRs) and 95% confidence intervals (95% CIs) were calculated. The data were compiled through the random effects model. Main Results. Fifteen studies were included (21,012 women and 21,647 fetuses). No statistically significant difference was found between women who received antioxidant treatment and women who received placebo for preeclampsia (RR  = 0.92; 95% CI: 0.82–1.04), severe preeclampsia (RR  = 1.03; 95% CI: 0.87–1.22), preterm birth (RR  = 1.03; 95% CI: 0.94–1.14), and small for gestational age antioxidants group compared to placebo, but without significant statistical difference (RR  = 1.24; 95% CI: 0.85–1.80). Conclusions. The available evidence reviewed does not support the use of antioxidants during pregnancy for the prevention of preeclampsia and other outcomes. PMID:22593668

  5. Risks associated with preeclampsia: possible mechanisms

    Directory of Open Access Journals (Sweden)

    Bentolhoda Sahebnasagh

    2017-01-01

    Full Text Available Findings have shown that low serum 25-hydroxy vitamin D level is a possible risk factor for incidence of preeclampsia during pregnancy. Vitamin D has important effects on multiple biological pathways, including angiogenesis. Some studies have shown that vitamin D deficiency is highly prevalent among women suffering from preeclampsia, influencing immune modulation and vascular function. Evidence has shown that an imbalance of pro-antigenic and anti-angiogenic proteins can be considered as a possible etiological factor in the development of preeclampsia. Besides, there is a series of studies linking the renin–angiotensin aldosterone system (RAAS with preeclampsia. In this article, we review the current studies evaluating the association between maternal vitamin D status and vascular health, metabolism, placental immune function and the risk of preeclampsia. We provided evidence of the different factor involved in the metabolism of vitamin D and vitamin D receptor (VDR expression, gene regulations, immune function, and chronic disease when vitamin D is used optimally.

  6. Comparing caring practices between two groups of pregnant women in the city of Sincelejo Comparación de las prácticas de cuidado en dos grupos de gestantes en la ciudad de Sincelejo

    Directory of Open Access Journals (Sweden)

    GARCÍA GARCÍA LUZ MARINA

    2008-07-01

    gestantes adolescentes y otro grupo de gestantes adultas que asisten a control prenatal en Sincelejo, durante los meses de julio y septiembre de 2006, se desarrolló un estudio descriptivo, cuantitativo y transversal, con una muestra de 97 gestantes adolescentes entre 15 y 19 años y de 153 gestantes adultas entre 20 y 45 años, sin patologías asociadas, a quienes se les aplicó un instrumento sobre prácticas de cuidado, validado por la Universidad Nacional de Colombia, sede Bogotá. Estas prácticas se clasificaron en buenas, regulares y malas, en los dos grupos, para establecer la comparación cuantitativa de las mismas. Los principales resultados fueron: diferencias estadísticamente significativas en las dimensiones de estimulación prenatal, higiene y cuidados personales, alimentación y sustancias no beneficiosas; en estas cuatro dimensiones el resultado de buenas prácticas fue más favorable para las gestantes adultas; no se encontró diferencia significativa en las dimensiones de ejercicio y descanso, y sistemas de apoyo. La mayoría de las gestantes adultas (81,7% realizaban actividades domésticas que les producían cansancio; 23,53% no desarrollaban actividades recreativas; 25,77% de las gestantes adolescentes y 41,18% de las gestantes adultas consumían lácteos. 19,59% de las gestantes adolescentes y 6,54% de las adultas no evitaban el consumo de licor y 4,12% de las gestantes adolescentesy0,65% de lasgestantes adultas habían consumido sustancias psicoactivas. Tanto adolescentes (68,04% como adultas (52,29% realizaban prácticas de estimulación prenatal catalogadas como regulares. Solo 31,37% de las gestantes adultas y 21,65% de las gestantes adolescentes tenían prácticas adecuadas de estimulación prenatal.

  7. Comparación de las prácticas de cuidado en dos grupos de gestantes en la ciudad de Sincelejo Comparing caring practices between two groups of pregnant women in the city of Sincelejo

    Directory of Open Access Journals (Sweden)

    LUZ MARINA GARCÍA GARCÍA

    2008-07-01

    Full Text Available Para comparar las prácticas de cuidado que realizan consigo mismas y con su hijo por nacer un grupo de gestantes adolescentes y otro grupo de gestantes adultas que asisten a control prenatal en Sincelejo, durante los meses de julio y septiembre de 2006, se desarrolló un estudio descriptivo, cuantitativo y transversal, con una muestra de 97 gestantes adolescentes entre 15 y 19 años y de 153 gestantes adultas entre 20 y 45 años, sin patologías asociadas, a quienes se les aplicó un instrumento sobre prácticas de cuidado, validado por la Universidad Nacional de Colombia, sede Bogotá. Estas prácticas se clasificaron en buenas, regulares y malas, en los dos grupos, para establecer la comparación cuantitativa de las mismas. Los principales resultados fueron: diferencias estadísticamente significativas en las dimensiones de estimulación prenatal, higiene y cuidados personales, alimentación y sustancias no beneficiosas; en estas cuatro dimensiones el resultado de buenas prácticas fue más favorable para las gestantes adultas; no se encontró diferencia significativa en las dimensiones de ejercicio y descanso, y sistemas de apoyo. La mayoría de las gestantes adultas (81,7% realizaban actividades domésticas que les producían cansancio; 23,53% no desarrollaban actividades recreativas; 25,77% de las gestantes adolescentes y 41,18% de las gestantes adultas consumían lácteos. 19,59% de las gestantes adolescentes y 6,54% de las adultas no evitaban el consumo de licor y 4,12% de las gestantes adolescentesy0,65% de lasgestantes adultas habían consumido sustancias psicoactivas. Tanto adolescentes (68,04% como adultas (52,29% realizaban prácticas de estimulación prenatal catalogadas como regulares. Solo 31,37% de las gestantes adultas y 21,65% de las gestantes adolescentes tenían prácticas adecuadas de estimulación prenatal.In order to compare the care practices that a group of pregnant women exercise in respect of themselves and their

  8. Microvascular remodelling in preeclampsia: quantifying capillary rarefaction accurately and independently predicts preeclampsia.

    Science.gov (United States)

    Antonios, Tarek F T; Nama, Vivek; Wang, Duolao; Manyonda, Isaac T

    2013-09-01

    Preeclampsia is a major cause of maternal and neonatal mortality and morbidity. The incidence of preeclampsia seems to be rising because of increased prevalence of predisposing disorders, such as essential hypertension, diabetes, and obesity, and there is increasing evidence to suggest widespread microcirculatory abnormalities before the onset of preeclampsia. We hypothesized that quantifying capillary rarefaction could be helpful in the clinical prediction of preeclampsia. We measured skin capillary density according to a well-validated protocol at 5 consecutive predetermined visits in 322 consecutive white women, of whom 16 subjects developed preeclampsia. We found that structural capillary rarefaction at 20-24 weeks of gestation yielded a sensitivity of 0.87 with a specificity of 0.50 at the cutoff of 2 capillaries/field with the area under the curve of the receiver operating characteristic value of 0.70, whereas capillary rarefaction at 27-32 weeks of gestation yielded a sensitivity of 0.75 and a higher specificity of 0.77 at the cutoff of 8 capillaries/field with area under the curve of the receiver operating characteristic value of 0.82. Combining capillary rarefaction with uterine artery Doppler pulsatility index increased the sensitivity and specificity of the prediction. Multivariable analysis shows that the odds of preeclampsia are increased in women with previous history of preeclampsia or chronic hypertension and in those with increased uterine artery Doppler pulsatility index, but the most powerful and independent predictor of preeclampsia was capillary rarefaction at 27-32 weeks. Quantifying structural rarefaction of skin capillaries in pregnancy is a potentially useful clinical marker for the prediction of preeclampsia.

  9. Vinculação da gestante e apego materno fetal

    Directory of Open Access Journals (Sweden)

    Eluisa Bordin Schmidt

    2009-08-01

    Full Text Available Este trabalho verificou as relações existentes entre o tipo de vinculação da gestante, sintomas de ansiedade, depressão e nível de apego materno fetal. Participaram 136 gestantes entre 18 e 42 anos de idade, do 6º ao 9º mês de gestação com escolaridade mínima de 5ª série. Foi realizado um estudo quantitativo, transversal, correlacional. Os instrumentos utilizados foram: Ficha de Dados Sociodemográficos, Escala de Vinculação do Adulto (EVA, Escala de Apego Materno Fetal (MFAS, Inventário de Depressão de Beck (BDI e Inventário de Ansiedade de Beck (BAI. A análise dos dados foi realizada por meio de estatística descritiva, teste exato de Fischer, simulações de Monte Carlo e Correlação de Pearson. Os resultados indicaram que existe associação significativa entre o tipo de vinculação da gestante e o apego materno fetal, e sintomas depressivos. As gestantes que apresentaram uma vinculação segura evidenciaram apego materno fetal alto e sintomas depressivos e ansiosos mínimos.

  10. Apego materno fetal em gestantes que vivem com HIV/Aids

    Directory of Open Access Journals (Sweden)

    Evelise Rigoni de Faria

    2013-06-01

    Full Text Available A gestação no contexto do HIV/Aids é geralmente acompanhada de intensa ansiedade devido à possível transmissão materno infantil do vírus. Este estudo investigou o apego materno fetal em gestantes que viviam com HIV (n = 88, em comparação a gestantes não portadoras do vírus (n = 79, através da Escala de Apego Materno fetal. Os resultados não revelaram diferenças entre as gestantes quanto ao escore total de apego materno fetal. Entretanto, os dados sugerem que o apego materno fetal pode se manifestar de maneira peculiar entre as gestantes que vivem com HIV/Aids: as interações mãe-bebê parecem focar o momento presente da gestação, e os cuidados de saúde com o bebê parecem atrelados àqueles voltados à saúde materna diante da infecção. É possível que a escala não seja suficientemente sensível para eventuais diferenças associadas ao contexto do HIV/Aids. Sugere-se que novos estudos revisem os itens da escala visando maior aproximação das particularidades suscitadas pela infecção quanto ao apego materno fetal.

  11. A brief overview of preeclampsia.

    Science.gov (United States)

    Al-Jameil, Noura; Aziz Khan, Farah; Fareed Khan, Mohammad; Tabassum, Hajera

    2014-02-01

    Preeclampsia (PE) is a leading cause of maternal mortality and morbidity worldwide. It occurs in women with first or multiple pregnancies and is characterized by new onset hypertension and proteinuria. Improper placentation is mainly responsible for the disease. If PE remains untreated, it moves towards more serious condition known as eclampsia. Hypertension, diabetes mellitus, proteinuria, obesity, family history, nulliparity, multiple pregnancies and thrombotic vascular disease contribute as the risk factors for PE. PE triggered metabolic stress causes vascular injury, thus contributing to the development of cardiovascular disease (CVD) and/or chronic kidney disease (CKD) in future. This risk appears to be increased especially in women with a history of recurrent PE and eclampsia. Clinically increased serum levels of sFlt-1 and decreased placental growth factor (PIGF) and vascular endothelial growth factor (VEGF) represent the severe condition of PE. The clinical findings of sever PE are assorted by the presence of systemic endothelial dysfunction, microangiopathy, the liver (hemolysis, elevated liver function tests and low platelet count, namely HELLP syndrome) and the kidney (proteinuria). The early detection of PE is one of the most important goals in obstetrics.

  12. Genesis of Preeclampsia: An Epidemiological Approach

    Science.gov (United States)

    Salvador-Moysén, Jaime; Martínez-López, Yolanda; Ramírez-Aranda, José M.; Aguilar-Durán, Marisela; Terrones-González, Alberto

    2012-01-01

    There are analyzed some of the main aspects related to the causality of preeclampsia, privileging two types of models: the clinic model and the epidemiologic model, first one represented by the hypothesis of the reduced placental perfusion and the second one considering the epidemiologic findings related to the high levels of psychosocial stress and its association with preeclampsia. It is reasoned out the relevance of raising the causality of the disease from an interdisciplinary perspective, integrating the valuable information generated from both types, clinical and epidemiologic, and finally a tentative explanatory model of preeclampsia is proposed, the subclinical and sociocultural aspects that predispose and trigger the disease are emphasized making aspects to stand out: the importance of reduced placental perfusion as an indicator of individual risk, and the high levels of physiological stress, as a result of the unfavorable conditions of the psychosocial surroundings (indicator of population risk) of the pregnant women. PMID:22462008

  13. Screening for group B Streptococcus in pregnant women: a systematic review and meta-analysis Rastreo de Streptococcus del grupo B en gestantes: revisión sistemática y metanálisis Rastreamento de Streptococcus do grupo B em gestantes: revisão sistemática e metanálise

    Directory of Open Access Journals (Sweden)

    Mônica Taminato

    2011-12-01

    Full Text Available Infection with Group B Streptococcus (GBS is considered an important public health problem. It is associated with: Neonatal sepsis, meningitis, pneumonia, neonatal death, septic abortion, chorioamnionitis, endometritis and other perinatal infections. The aim of this study was to determine the best screening strategy for GBS in pregnant women. For this a systematic review and meta-analysis were carried out in the Nursing Department of the Federal University of São Paulo, Cochrane Center, Brazil. Sources used were, EMBASE, LILACS, Medline, list of references, personal communication and the Cochrane library. The criterion for the selection of the studies was; studies which analyze some type of screening for GBS in pregnant women. Independent of the comparator, all analyses were in favor of a universal screening program for reducing the incidence of neonatal sepsis. The evidence obtained in this study suggests that the strategy of universal screening of pregnant women associated with the use of prophylactic antibiotics is safe and effective.La infección por Streptococcus del grupo B (GBS es considerada un importante problema de salud pública. Los estreptococos están asociados a: sepsis neonatal, meningitis, neumonía, muerte neonatal, aborto séptico, corioamnionitis, endometritis y otras infecciones perinatales. El objetico del estudio fue determinar la mejor estrategia de rastreo de GBS en gestantes. Se trata de una revisión Sistemática con Metanálisis. Fue realizada en el Departamento de Enfermería de la Universidad Federal de Sao Paulo, Centro Cochrane de Brasil. Se utilizaron las siguientes fuentes: EMBASE, LILACS, Medline, lista de referencias bibliográficas, comunicación personal y Cochrane Library. Como criterio para la selección de los estudios, se escogieron los que analizaron algún tipo de rastreo para GBS en gestantes. Independientemente del comparador, todos los análisis fueron favorables al programa de screening universal

  14. Ethical issues related to screening for Preeclampsia

    DEFF Research Database (Denmark)

    Jørgensen, Jennifer M.; Hedley, Paula L.; Gjerris, Mickey

    2014-01-01

    The implementation of new methods of treating and preventing disease raises many question of both technical and moral character. Currently, many studies focus on developing a screening test for preeclampsia (PE), a disease complicating 2–8% of pregnancies, potentially causing severe consequences...... feasibility and clinical efficacy, it also requires an analysis of how the test influences the conditions and choices for those tested. This study evaluates state-of-the-art techniques for preeclampsia screening in an ethical framework, pointing out the central areas of moral relevance within the context...

  15. Preeclampsia, of mice and women.

    Science.gov (United States)

    Sones, Jenny L; Davisson, Robin L

    2016-08-01

    Preeclampsia (PE) is a devastating disorder of pregnancy that affects up to 8% of pregnant women in the United States. The diagnosis of PE is made by the presentation of new-onset hypertension, ≥140 mmHg systolic blood pressure (BP) or ≥90 mmHg diastolic BP, and either proteinuria or another accompanying sign/symptom, such as renal insufficiency, thrombocytopenia, hepatic dysfunction, pulmonary edema, or cerebral/visual. These signs can occur suddenly and without warning. PE that presents before 34 wk of gestation is considered early onset and carries a greater risk for perinatal morbidity/mortality than late-onset PE that occurs at or after 34 wk of gestation. At this time there is no cure for PE, and the only effective treatment is delivery of the baby and placenta. If allowed to progress to eclampsia (PE with neurologic involvement), seizures will occur and possibly death through stroke. PE also carries the risk of significant fetal and neonatal morbidity/mortality in addition to long-term health risks for mother and child. Despite significant research efforts to accurately predict, diagnose, and treat PE, a cure eludes us. Elucidating the pathophysiological mechanisms that can cause PE will aid in our ability to accurately prevent, manage, and treat PE to avoid maternal and fetal losses. Intense research efforts are focused on PE, and the mouse has proven to be a useful animal model for investigating molecular mechanisms that may hold the key to unraveling the mysteries of PE in women. Copyright © 2016 the American Physiological Society.

  16. Ser gestante soropositivo para o Vírus da Imunodeficiência Humana: uma leitura à luz do Interacionismo Simbólico Ser gestante seropositiva para el Virus de la inmunodeficiencia humana-HIV: una lectura bajo el marco teórico del Interaccionismo Simbólico Being pregnant seropositive and having acquired the human immunodeficiency Virus (HIV: a theoretical interpretation under the Symbolic Interactionism

    Directory of Open Access Journals (Sweden)

    Edilene Lins de Moura

    2010-04-01

    Full Text Available OBJETIVO: Descrever o contexto do cotidiano vivido por mulheres grávidas soropositivas para o Vírus da Imunodeficiência Humana (HIV, com enfoque na experiência de tornar-se grávida e assumir a gravidez. MÉTODOS: Os dados foram coletados por meio de entrevista gravada, com 14 gestantes sabidamente soropositivas para o HIV, que vivenciavam o terceiro trimestre de gravidez. O estudo fez uma leitura de dados brutos sobre expectativas e ações de gestantes soropositivas para o HIV, à luz do Interacionismo Simbólico. RESULTADOS: um dos aspectos encontrados mostrou que as mulheres HIV positivo assumem a gravidez, ainda que esta seja inesperada. CONCLUSÕES: os dados são um alerta para os profissionais de enfermagem que devem promover ações educativas para atender às demandas dessa mulher.OBJETIVO: Describir el contexto cotidiano vivido por mujeres embarazadas y seropositivas para el virus de la inmunodeficiencia humana (HIV, con enfoque en la experiencia de estar embarazada y aceptar ese estado. MÉTODOS: Los datos fueron recolectados por medio de entrevista grabada, con 14 gestantes sabidamente seropositivas para el HIV, que se encontraban en el tercer trimestre de embarazo. El estudio hizo una lectura de los datos brutos sobre expectativas y acciones de las gestantes seropositivas para el HIV, bajo el marco teórico del Interaccionismo Simbólico. RESULTADOS: Uno de los aspectos encontrados mostró que las mujeres infectadas con Sida aceptan el embarazo, inclusive cuando ocurre inesperadamente. CONCLUSIONES: Los datos sirven de para los profesionales de enfermería para que promuevan acciones educativas que atiendan las necesidades de esas mujeres.OBJECTIVE: To describe the context of everyday life experienced by pregnant women seropositive for human immunodeficiency virus (HIV, focusing on the experience of becoming pregnant and accepting that condition. METHODS: Data were collected recording interviews with 14 pregnant women known to

  17. Salud bucal: representaciones sociales en madres gestantes de una población urbana. Medellín, Colombia Oral health: social representations among pregnant mothers. Medellin, Colombia

    Directory of Open Access Journals (Sweden)

    Gloria Escobar-Paucar

    2011-11-01

    Full Text Available A partir de la teoría de las representaciones sociales, se realizó una investigación cualitativa con el propósito de comprender las representaciones sociales del proceso salud-enfermedad bucal en madres gestantes de una población urbana. Se entrevistaron 28 mujeres adultas asistentes al programa prenatal en una institución de salud de la ciudad de Medellín. Las entrevistas fueron grabadas y transcritas y se analizaron mediante codificación abierta, axial y selectiva, de acuerdo con la teoría fundada. Los hallazgos revelaron que si bien para las madres gestantes la boca del hijo no ocupa un lugar preponderante al inicio del ciclo vital, gana importancia con el proceso de crecimiento y desarrollo del niño, cuando además de su papel en la masticación y alimentación, adquiere una carga social relevante. El análisis dio cuenta de cómo confluyen en las madres de una población urbana representaciones arraigadas en la tradición, con nuevas visiones en cuya construcción hay elementos de los discursos profesionales y de los medios de comunicación; entre ellas, la estrecha relación salud bucal-dientes, la salud atada a prácticas saludables y a la utilización de servicios de salud y salud bucal como ventaja social, relacionada con la estética.Based on the theory of social representations, a qualitative investigation was conducted in order to assess social representations in oral heath in pregnant mothers living in an urban environment. Twenty-eight pregnant adult women attending a prenatal program at a health institution in the city of Medellín, Colombia, were interviewed. The interviews were recorded and transcribed; analysis was performed through open, axial and selective coding, in line with grounded theory. Findings revealed that although pregnant mothers are not greatly concerned about oral health after birth and in early childhood, it increases in importance during growth and development of the child when, besides chewing and

  18. Determination of coagulopathy complicating severe preeclampsia ...

    African Journals Online (AJOL)

    Preeclampsia is defined as gestational hypertension plus proteinuria of 300 mg or more in 24 hour urine sample collection or persistent proteinuria of at least 30 mg/dl (at least 1+ on dipstick) in random urine samples.[5] Eclampsia is defined as the onset of seizures and/or unexplained coma during pregnancy, intrapartum.

  19. Placenta Copper Transport Proteins in Preeclampsia

    Science.gov (United States)

    Placental insufficiency underlying preeclampsia (PE) is associated with impaired placental angiogenesis. As copper (Cu) is essential to angiogenesis, we investigated differences in the expression of placental Cu transporters Menkes (ATP7A), Wilsons (ATP7B) and the Cu chaperone (CCS) for superoxide d...

  20. Paroxysmal Nocturnal Hemoglobinuria Superimposed with Preeclampsia

    Directory of Open Access Journals (Sweden)

    Mann-Ling Chen

    2006-09-01

    Conclusion: The most frequent causes of PNH-related fetomaternal morbidity and mortality are hemolysis and thrombosis. The situation becomes even more complicated when PNH is superimposed with preeclampsia. Appropriate clinical surveillance, awareness of the potential risks of hemolysis and thrombosis, as well as evaluation of fetal wellbeing are essential.

  1. Prediction of preeclampsia with angiogenic biomarkers

    DEFF Research Database (Denmark)

    Andersen, Louise Bjørkholt; Dechend, Ralf; Jørgensen, Jan Stener

    2016-01-01

    OBJECTIVE: We aimed to investigate how maternal serum soluble Fms-like kinase 1 (sFlt-1), placental growth factor (PlGF), and sFlt-1/PlGF ratio prospectively associate to preeclampsia (PE) and clinical subtypes. METHODS: In an unselected cohort of 1909 pregnant women, sFlt-1 and PlGF were measured...

  2. Vitamin D, secondary hyperparathyroidism, and preeclampsia.

    Science.gov (United States)

    Scholl, Theresa O; Chen, Xinhua; Stein, T Peter

    2013-09-01

    Secondary hyperparathyroidism, which is defined by a high concentration of intact parathyroid hormone when circulating 25-hydroxyvitamin D [25(OH)D] is low, is a functional indicator of vitamin D insufficiency and a sign of impaired calcium metabolism. Two large randomized controlled trials examined effects of calcium supplementation on preeclampsia but did not consider the vitamin D status of mothers. We examined the association of secondary hyperparathyroidism with risk of preeclampsia. Circulating maternal 25-hydroxyvitamin D [25(OH)D] and intact parathyroid hormone were measured at entry to care (mean ± SD: 13.7 ± 5.7 wk) using prospective data from a cohort of 1141 low-income and minority gravidae. Secondary hyperparathyroidism occurred in 6.3% of the cohort and 18.4% of women whose 25(OH)D concentrations were 20 ng/mL were not at increased risk. Intact parathyroid hormone was related to higher systolic and diastolic blood pressures and arterial pressure at week 20 before clinical recognition of preeclampsia. Energy-adjusted intakes of total calcium and lactose and circulating 25(OH)D were correlated inversely with systolic blood pressure or arterial pressure and with parathyroid hormone. Some women who are vitamin D insufficient develop secondary hyperparathyroidism, which is associated with increased risk of preeclampsia.

  3. Genetic Aspects of Preeclampsia and the HELLP Syndrome

    Science.gov (United States)

    Mortensen, Jan Helge; Nagy, Bálint

    2014-01-01

    Both preeclampsia and the HELLP syndrome have their origin in the placenta. The aim of this study is to review genetic factors involved in development of preeclampsia and the HELLP syndrome using literature search in PubMed. A familial cohort links chromosomes 2q, 5q, and 13q to preeclampsia. The chromosome 12q is coupled with the HELLP syndrome. The STOX1 gene, the ERAP1 and 2 genes, the syncytin envelope gene, and the −670 Fas receptor polymorphisms are involved in the development of preeclampsia. The ACVR2A gene on chromosome 2q22 is also implicated. The toll-like receptor-4 (TLR-4) and factor V Leiden mutation participate both in development of preeclampsia and the HELLP syndrome. Carriers of the TT and the CC genotype of the MTHFR C677T polymorphism seem to have an increased risk of the HELLP syndrome. The placental levels of VEGF mRNA are reduced both in women with preeclampsia and in women with the HELLP syndrome. The BclI polymorphism is engaged in development of the HELLP syndrome but not in development of severe preeclampsia. The ACE I/D polymorphism affects uteroplacental and umbilical artery blood flows in women with preeclampsia. In women with preeclampsia and the HELLP syndrome several genes in the placenta are deregulated. Preeclampsia and the HELLP syndrome are multiplex genetic diseases. PMID:24991435

  4. Double hit of NEMO gene in preeclampsia.

    Directory of Open Access Journals (Sweden)

    Agata Sakowicz

    Full Text Available The precise etiology of preeclampsia is unknown. Family studies indicate that both genetic and environmental factors influence its development. One of these factors is NFkB, whose activation depends on NEMO (NFkB essential modulator. This is the first study to investigate the association between the existence of single nucleotide variant of the NEMO gene and the appearance of preeclampsia. A total of 151 women (72 preeclamptic women and 79 controls and their children were examined. Sanger sequencing was performed to identify variants in the NEMO gene in the preeclamptic mothers. The maternal identified variants were then sought in the studied groups of children, and in the maternal and child controls, using RFLP-PCR. Real-time RT-PCR was performed to assess NEMO gene expression in maternal blood, umbilical cord blood and placentas. The sequencing process indicated the existence of two different variants in the 3'UTR region of the NEMO gene of preeclamptic women (IKBKG:c.*368C>A and IKBKG:c.*402C>T. The simultaneous occurrence of the TT genotype in the mother and the TT genotype in the daughter or a T allele in the son increased the risk of preeclampsia development 2.59 fold. Additionally, we found that the configuration of maternal/fetal genotypes (maternal TT/ daughter TT or maternal TT/son T of IKBKG:c.*402C/T variant is associated with the level of NEMO gene expression. Our results showed that, the simultaneous occurrence of the maternal TT genotype (IKBKG:c.*402C>T variants and TT genotype in the daughter or T allele in the son correlates with the level of NEMO gene expression and increases the risk of preeclampsia development. Our observations may offer a new insight into the genetic etiology and pathogenesis of preeclampsia.

  5. Subfecundity as a correlate of preeclampsia: A study within the Danish National Birth Cohort

    DEFF Research Database (Denmark)

    Basso, Olga; Weinberg, Clarice R.; Baird, Donna D.

    2003-01-01

    A long interpregnancy interval is associated with preeclampsia. If some women experiencing a long interval between births had difficulty conceiving, subfecundity and preeclampsia may share a common etiology. Therefore, the authors examined the association between subfecundity and preeclampsia. By...

  6. On the pathology of preeclampsia : genetic variants, complement dysregulation and angiogenesis

    NARCIS (Netherlands)

    Buurma, Aletta Atje Jacoba

    2013-01-01

    Preeclampsia is a pregnancy-specific condition that originates in the placenta. Despite decades of research, its pathogenesis remains largely unknown. However, several risk factors for preeclampsia have been identified, including a (family) history of preeclampsia, autoimmune disease and conditions

  7. AIDS em gestantes: possibilidade de reduzir a transmissão vertical

    Directory of Open Access Journals (Sweden)

    Fernanda Scherer Wiethäuper

    2003-06-01

    Full Text Available Neste estudo, buscamos investigar o conhecimento que gestantes possuem sobre a transmissão vertical, o comprometimento do feto e o significado do resultado soropositivo que a identifica como infectada pelo HIV. A pesquisa exploratória, de natureza qualitativa, foi desenvolvida em Unidades Sanitárias de São Leopoldo/RS. A análise permitiu captar a percepção de 63 gestantes entre 16 e 40 anos sobre os motivos e os significados para realização do teste, os conhecimentos e vivências do cotidiano e as perspectivas e cuidados com o bebê. Os resultados trazem um alerta aos profissionais que atuam no pré-natal, visto que necessitam atender uma complexidade de situações que emergem quando se vincula gestação e AIDS.

  8. Factores de riesgo para la preeclampsia severa y temprana en el Hospital General de Medellín (HGM 1999-2001

    Directory of Open Access Journals (Sweden)

    Mercedes Jimeno

    2001-04-01

    Full Text Available Se ha calculado, por estudios en otras partes del mundo, que la
    frecuencia de presentación del Síndrome Hipertensivo del embarazo
    oscila entre 7% y 10% de los embarazos, y que el 30% corresponde a Preeclampsia y de éstos, menos del 10% a Preeclampsia temprana. Entre los factores maternos, uno de los que más peso ha tenido es la paridad materna y en segundo lugar la edad materna. Además, también se ha encontrado asociación con el antecedente de hipertensión esencial. Se pretendió con este estudio evaluar si la presencia de factores de riesgo en esta población se relaciona con la presentación del síndrome en sus formas severas y con las formas tempranas del mismo.

  9. Uso de hierbas medicinales en mujeres gestantes y en lactancia en un hospital universitario de Bogotá (Colombia The use of herbal medicine among pregnant and lactating women attending a university hospital in Bogota, Colombia

    Directory of Open Access Journals (Sweden)

    Gloria Paulina Pulido Acuña

    2012-12-01

    Full Text Available Las mujeres durante la gestación y lactancia utilizan diferentes hierbas y es escasa la información en el ámbito clínico en Colombia. Objetivo: Describir las prácticas relacionadas con el uso de hierbas en mujeres gestantes y en lactancia del Hospital de San José, Bogotá (Colombia. Metodología: Estudio de corte transversal. Con un cuestionario estructurado se indagó el uso, la frecuencia, el modo y razones de uso, de las hierbas medicinales y de quién se aprendió la práctica. Resultados: El uso de hierbas en mujeres gestantes y en lactancia fue de 33.6% (IC95%: 29.2% - 38% y 36.6% (IC95%: 30.8% - 42.3%, respectivamente. En el grupo de gestantes la hierba más usada fue la manzanilla (36.7% y en las mujeres en lactancia fue el hinojo (65%. Conclusión: Las mujeres gestantes y en lactancia, utilizan hierbas para las molestias del embarazo, acelerar el parto, disminuir el frío y promover la producción de leche.The use of herbal supplements is a common practice about pregnant and lactating women, however in Colombia there is limited data regarding the extent of women's use of herbal medicines during pregnancy and breastfeeding. The aim of this study was to describe the patterns of herbal medication use among pregnant and lactating women at the Hospital San Jose in Bogota, Colombia. Methods: Cross-sectional study. A questionnaire was designed to measure the frequency of herbal supplementation, why women took the herbal medicine, form of supplements, and who recommended the supplements or how did they learn about the herbal supplements. Results: The use of herbal supplements among pregnant and lactating women is 33.6% (CI 95%: 29.2%-38% and 36.6 (CI 95%: 30.8%-42.3%, respectively. The most common supplement used by pregnant women is Chamomile (36,7%, and among lactating women is Fennel (Foeniculum vulgare (65%. Conclusion: Pregnant and breastfeeding women use herbal supplements for specific pregnancy-related problems, to induce labor, to

  10. Insatisfação corporal em gestantes: uma revisão integrativa da literatura

    Directory of Open Access Journals (Sweden)

    Juliana Fernandes Filgueiras Meireles

    2015-07-01

    Full Text Available Resumo A imagem corporal de gestantes deve ser alvo de atenção por parte dos profissionais, tendo em vista a promoção da saúde materna infantil. O objetivo da presente revisão integrativa foi analisar a literatura sobre imagem e insatisfação corporal em gestantes. Foram buscados artigos nas bases de dados Scopus, PubMed, BVS e PsycINFO utilizando o cruzamento de “pregnancy” com as palavras-chave: “body image” e “body dissatisfaction”. Após a adoção dos critérios de inclusão e exclusão foram analisados 40 estudos. Estes apontam dados inconclusivos quanto à insatisfação corporal durante a gestação. Presença de sintomas depressivos, baixa autoestima, atitude alimentar inadequada e ganho de peso fora dos limites recomendados têm sido associados a uma imagem corporal negativa. Contradições nos achados podem estar relacionados às diferenças nos instrumentos utilizados para mensurar a imagem corporal. Pelo possível impacto de uma imagem corporal negativa durante a gestação na saúde materna e infantil, são recomendadas novas investigações, em especial o desenvolvimento de um instrumento avaliativo de imagem corporal específico para gestantes.

  11. Corrimentos vaginais em gestantes: comparacao da abordagem sindromica com exames da pratica clinica da enfermagem

    Directory of Open Access Journals (Sweden)

    Thais Marques Lima

    2013-12-01

    Full Text Available Estudo avaliativo de abordagem quantitativa, com amostra de 104 gestantes, com o objetivo de comparar os achados de infecções vaginais em gestantes obtidos por meio do fluxograma de corrimento vaginal com exames presentes na prática clínica da Enfermagem. Os dados foram coletados por meio de entrevista e exame ginecológico realizados de janeiro a julho de 2011. O fluxograma não se mostrou eficaz na identificação de candidíase e tricomoníase, apresentou baixa sensibilidade (0,0%; 50% e valor preditivo positivo (0,0%; 3,6% para as duas infecções e baixa especificidade para tricomoníase (46%. Mostrou-se satisfatório para vaginose bacteriana, com alta sensibilidade (100%, valor preditivo negativo (100% e acurácia (74%. Conclui-se que o emprego do fluxograma precisa ser reavaliado, visto que não foi eficaz em identificar infecções importantes em gestantes. Os esforços para o desenvolvimento de testes eficazes devem ser contínuos, com intuito de prevenir a disseminação de infecções e reduzir tratamentos desnecessários.

  12. Is human placenta proteoglycan remodeling involved in pre-eclampsia?

    OpenAIRE

    Warda, Mohamad; Zhang, Fuming; Radwan, Moustafa; Zhang, Zhenqing; Kim, Nari; Kim, Young Nam; Linhardt, Robert J.; Han, Jin

    2007-01-01

    Impaired placento-fetal communication is a coherent symptom of exaggerated pre-eclampsia. The impact of the cellular expression of different glycosaminoglycans (GAGs) in this event on the placenta in pre-eclampsia is still obscure. This is the first study aimed at discovering the relationship between structural alterations of different sulfated GAGs at the molecular level and the development of pre-eclampsia in inflicted placenta. Sulfated GAGs were isolated and purified from control and pre-...

  13. Plaquetas e hipertensión arterial durante el posparto

    OpenAIRE

    Sanabria Vera, Charles; Núñez González, José; Rojas González, Liliana; Urdaneta, Baldimiro

    2001-01-01

    Objetivo: Determinar el contaje plaquetario posparto en preclampsia, eclampsia e hipertensión arterial crónica con preeclampsia sobreañadida. Método: Se cuantificaron las plaquetas pre y posparto de las gestantes ingresadas se repitieron cada 12 horas hasta normalizarse el reporte de trombocitopenia (< 150 000 x mm3). Ambiente: Maternidad del Hospital Central "Dr. Urquinaona". Maracaibo, Estado Zulia. Resultados: Hubo 85 pacientes admitidas; 21 con preeclampsia severa, 10 con eclampsia y 19 c...

  14. Pre-eclampsia: a life-threatening pregnancy syndrom

    Directory of Open Access Journals (Sweden)

    Andrea Brazdova

    2014-10-01

    Full Text Available Pre-eclampsia is a serious pathological state affecting 5-10% of pregnant women. Currently, it is diagnosed in the second half of pregnancy, particularly after the 20th week. Symptoms mostly correspond to the changes of blood vessels and kidneys. The severity of pre-eclampsia is proportional to symptomatic manifestations, thus the more symptoms present, the higher is of pre-eclampsia development. Although there are several studies dealing with pre-eclampsia pathology, the complete etiology is still unknown. In this review paper, several theories are presented and discussed.

  15. Metabolomic biomarkers in serum and urine in women with preeclampsia.

    Directory of Open Access Journals (Sweden)

    Marie Austdal

    Full Text Available To explore the potential of magnetic resonance (MR metabolomics for study of preeclampsia, for improved phenotyping and elucidating potential clues to etiology and pathogenesis.Urine and serum samples from pregnant women with preeclampsia (n = 10, normal pregnancies (n = 10 and non-pregnant women (n = 10 matched by age and gestational age were analyzed with MR spectroscopy and subjected to multivariate analysis. Metabolites were then quantified and compared between groups.Urine and serum samples revealed clear differences between women with preeclampsia and both control groups (normal pregnant and non-pregnant women. Nine urine metabolites were significantly different between preeclampsia and the normal pregnant group. Urine samples from women with early onset preeclampsia clustered together in the multivariate analysis. The preeclampsia serum spectra showed higher levels of low and very-low density lipoproteins and lower levels of high-density lipoproteins when compared to both non-pregnant and normal pregnant women.The MR determined metabolic profiles in urine and serum from women with preeclampsia are clearly different from normal pregnant women. The observed differences represent a potential to examine mechanisms underlying different preeclampsia phenotypes in urine and serum samples in larger studies. In addition, similarities between preeclampsia and cardiovascular disease in metabolomics are demonstrated.

  16. Influence on pregestacional obesity on the pre-eclampsia/eclampsia risk

    OpenAIRE

    Suárez González, Juan Antonio; Preciado Guerrero, Richard; Gutiérrez Machado, Mario; Cabrera Delgado, María Rosa; Marín Tápanes, Yoani; Cairo González, Vivian

    2013-01-01

    Introducción: una de las condiciones maternas que con mayor frecuencia complica el periodo de gestación y el parto es la obesidad. Objetivo: determinar la influencia de la obesidad en los resultados maternos y perinatales de gestantes con riesgo de preeclampsia/eclampsia. Métodos: estudio analítico y ambispectivo en el Hospital Universitario Ginecobstétrico "Mariana Grajales" de Santa Clara, provincia de Villa Clara, en el año 2010 en un grupo de gestantes con riesgo de preeclampsia/eclampsia...

  17. Developing Potential Candidates of Preclinical Preeclampsia

    Directory of Open Access Journals (Sweden)

    Sandra Founds

    2015-11-01

    Full Text Available The potential for developing molecules of interest in preclinical preeclampsia from candidate genes that were discovered on gene expression microarray analysis has been challenged by limited access to additional first trimester trophoblast and decidual tissues. The question of whether these candidates encode secreted proteins that may be detected in maternal circulation early in pregnancy has been investigated using various proteomic methods. Pilot studies utilizing mass spectrometry based proteomic assays, along with enzyme linked immunosorbent assays (ELISAs, and Western immunoblotting in first trimester samples are reported. The novel targeted mass spectrometry methods led to robust multiple reaction monitoring assays. Despite detection of several candidates in early gestation, challenges persist. Future antibody-based studies may lead to a novel multiplex protein panel for screening or detection to prevent or mitigate preeclampsia.

  18. Magnetic resonance imaging in eclampsia and preeclampsia

    International Nuclear Information System (INIS)

    Tsuzuki, Nobusuke; Matsuda, Hideo; Tokumaru, Aya M.

    2007-01-01

    Five patients with eclampsia (eclampsia group) and 38 patients with preeclampsia underwent MR imaging study. Of 38 patients with preeclampsia, 8 patients (21.1%) showed vasogenic edema (VE) and/or cerebral vasospasm (VC), or both. In the eclampsia group, 4 patients had VE, VC or both, and 1 patient had normal brain and cerebral arteries. There were no differences in MR imaging studies between two group. There was no definite correlation among clinical features, VE, and vasospasm (VS) in both groups. Discrepancy between territories of vasospastic arteries and locations of VE were noticed. Some patients in both groups demonstrated delayed VS. In conclusion, VE and VS are not major factors in the pathogenesis of eclampsia. (author)

  19. Niveles de hemoglobina en gestantes atendidas en establecimientos del Ministerio de Salud del Perú, 2011 Hemoglobin levels in pregnant women seen in health care centers of the peruvian ministry of health, 2011

    Directory of Open Access Journals (Sweden)

    Oscar Munares-García

    2012-09-01

    Full Text Available Objetivos. Determinar los niveles de hemoglobina y la prevalencia de anemia en gestantes atendidas en los establecimientos del Ministerio de Salud a nivel nacional. Materiales y métodos. Estudio transversal donde se analizó la base de datos del Sistema de Información del Estado Nutricional del Niño menor de 5 años y de la Gestante (SIEN. Se incluyó 287 691 registros de gestantes evaluadas en establecimientos del Ministerio de Salud del Perú en 2011, se analizaron los niveles de hemoglobina corregida a la altura, edad, edad gestacional, altitud a nivel del mar y prevalencia de anemia (leve, moderada y grave. Se aplicaron estadísticas descriptivas y chi cuadrado. Resultados. La prevalencia a nivel nacional de anemia en la gestante fue de 28,0% siendo anemia leve de 25,1%, moderada de 2,6% y grave de 0,2%. Los niveles de hemoglobina son mayores en mujeres con mayor edad y menores durante los primeros meses de gestación, la frecuencia de anemia decrece con la altitud. Asimismo, la prevalencia es mayor en departamentos de la sierra. Huancavelica fue el departamento con mayor prevalencia de anemia (53,6%, seguido de Puno con 51,0%. Conclusiones. Los niveles de hemoglobina son mayores conforme la edad materna es mayor, y menores conforme el trimestre de gestación y altitud. Huancavelica tiene la mayor prevalencia de anemia en gestantesObjectives. Determine hemoglobin levels and prevalence of anemia in pregnant women seen in health care centers of the Ministry of Health at national level. Materials and methods. Cross-cut study where the database of the Information System on the Nutritional Health of Children under 5 and Pregnant Women (SIEN were analyzed. 287 691 records of pregnant women examined at the health care centers of the Peruvian Ministry of Health in 2011 were included, hemoglobin levels corrected by height, age, gestational age, altitude and prevalence of anemia (light, moderate and serious were analyzed. Descriptive statistics and

  20. The feeling of loss and abandonment among pregnant displaced women -Bogotá La pérdida y el abandono en gestantes desplazadas-Bogotá

    Directory of Open Access Journals (Sweden)

    RUIZ DE CÁRDENAS CARMEN HELENA

    2007-12-01

    de Colombia. Setuvoencuentalateoríadel cuidadotransculturaldeLeininger (1978,lacualconsidera queelser humano está inmerso en una red de relaciones sociales y situado en un determinado contexto, aspectos estos que permean su comportamiento, es decir, la cultura en la cual él crece y vive hace partedesus prácticasdecuidado. Se usó el método de la etnoenfermería propuesto por Leininger (1985, con el objetivo de explorar el significado que tienen las gestantes desplazadas del cuidado de sí y de su hijo por nacer, desde lo émic punto de vista del nativo, en Bogotá (Localidades de Suba y Ciudad Bolívar. Las participantes fueron desplazadas de los departamentos de Tolima, Arauca, Cundinamarca, Caquetá, Bolívar, Guainía y Cauca, cuyas edades oscilaron entre los 14 y los 34 años, y el tiempo de desplazamiento estuvo entre los dos meses y un año. Los datos se obtuvieron por entrevista individual y grupal (doce participantes y por observación, y se aplicó el análisis etnográfico de Spradley (1980: dominios (categorías de significado que incluye otras categorías menores con sus relaciones semánticas, taxonomía (conjunto de categorías, análisis componencial (búsqueda de atributos asociados con símbolos culturales y temas (el más alto nivel de abstracción. Se obtuvo el tema El surgimiento de la esperanza en medio de la dificultad del desplazamiento de la gestante, con los subtemas: La pérdida y el abandono y El camino a seguir.

  1. Triggers for Preeclampsia Onset: a Case-Crossover Study.

    Science.gov (United States)

    Ford, Jane B; Schemann, Kathrin; Patterson, Jillian A; Morris, Jonathan; Herbert, Robert D; Roberts, Christine L

    2016-11-01

    Risk factors for preeclampsia are well established, whereas, the triggers associated with timing of preeclampsia onset are not. The aim of this study was to establish whether recent infection or other triggers were associated with timing of preeclampsia onset. We used a case-crossover design with preeclampsia cases serving as their own controls. Women with singleton pregnancies of ≥20 weeks gestation presenting at three hospitals were eligible for inclusion. Exposures to potential triggers were identified via guided questionnaire. Infective episodes included symptoms lasting >24 h. Preeclampsia was defined as hypertension (BP ≥140 mmHg and/or ≥90 mmHg) and proteinuria (protein/creatinine ratio ≥30 mg/mmol). Conditional logistic regression was used to compare the odds of exposure to potential triggers in the case windows (1-7 days preceding diagnosis of preeclampsia) and control windows (8-14 days prior to diagnosis); unadjusted odds ratios (ORs) are reported. Among 286 recruited women, 25 (8.7%) reported a new infection in the 7 days prior to preeclampsia onset and 21 (7.3%) in the 8-14 days prior. There was no significant association between onset of infection in the 7 days prior and preeclampsia diagnosis (OR 1.24, 95% CI 0.65, 2.34). Consumption of caffeine (OR 0.51, 95% CI 0.33, 0.77), spicy food (OR 0.49, 95% CI 0.30, 0.81), and alcohol (OR 0.26, 95% CI 0.10, 0.71) were strongly inversely associated with preeclampsia onset. Recent infection does not appear to trigger preeclampsia. Decreased consumption of caffeine, spicy food, and alcohol may be prodromal markers. Such behaviours may be early markers of imminent preeclampsia. © 2016 John Wiley & Sons Ltd.

  2. Serum homocyst(e)ine levels in women with preeclampsia.

    Science.gov (United States)

    Mayerhofer, K; Hefler, L; Zeisler, H; Tempfer, C; Bodner, K; Stöckler-Ipsiroglu, S; Mühl, A; Kaider, A; Schatten, C; Leodolter, S; Husslein, P; Kainz, C

    2000-03-24

    Endothelial dysfunction has been described as the final common pathophysiological pathway in the development of preeclampsia. Since it has been suggested that homocyst(e)ine damages endothelial cells, we measured serum homocyst(e)ine levels in women with preeclampsia and in healthy pregnant women in order to find a new prognostic parameter for women with preeclampsia. Forty-five women with preeclampsia and 45 healthy women with uncomplicated pregnancies, matched for age and parity, were entered into the study. Serum homocyst(e)ine levels were measured by gas chromatography-mass spectrometry analysis and correlated to clinical data. Logistic regression models were used to analyse the influence of serum homocyst(e)ine levels on the presence of preeclampsia versus healthy pregnant women and on the risk of premature termination of pregnancy due to preeclampsia. Median serum homocyst(e)ine levels in women with preeclampsia and healthy pregnant women were 14.2 (range 5.7-38.1) mumol/L and 15.1 (range 5.2-23.1) mumol/L, respectively (Mann-Whitney U-test, p = 0.8). In univariate logistic regression models, serum homocyst(e)ine levels had no significant influence on the odds of presenting with preeclampsia versus healthy pregnant women (univariate logistic regression model, p = 0.8) and on the odds of premature termination of pregnancy due to preeclampsia (univariate logistic regression model, p = 0.3). Serum homocyst(e)ine levels are not elevated in women with preeclampsia and are not associated with clinical outcome in women with preeclampsia.

  3. Early pre-eclampsia unmasks underlying IgA nephropathy

    Directory of Open Access Journals (Sweden)

    Mona Singh

    2010-12-01

    Full Text Available Mona Singh, Akhenaton Pappoe, Burl R DonDivision of Nephrology, University of California Davis Medical Center, Sacramento, CA, USAAbstract: Pre-eclampsia is the most ominous complication of pregnancy, and primary glomerular diseases can mimic pre-eclampsia in presentation. A patient presented at 21 weeks gestation with signs and symptoms of both pre-eclampsia and primary glomerular nephropathy. A critical clinical decision whether to continue or terminate the pregnancy was dependent on results of a renal biopsy. The biopsy noted the presence of both pre-eclampsia and immunoglobulin A (IgA nephropathy. Thus, the onset of pre-eclampsia unmasked the presence of unrecognized IgA nephropathy, and the IgA nephropathy was a risk factor for this patient developing pre-eclampsia. The results of a renal biopsy are key in distinguishing pre-eclampsia from other kidney diseases and instituting appropriate clinical management.Keywords: proteinuria, IgA nephropathy, renal biopsy, pre-eclampsia

  4. Elevated placental adenosine signaling contributes to the pathogenesis of preeclampsia.

    Science.gov (United States)

    Iriyama, Takayuki; Sun, Kaiqi; Parchim, Nicholas F; Li, Jessica; Zhao, Cheng; Song, Anren; Hart, Laura A; Blackwell, Sean C; Sibai, Baha M; Chan, Lee-Nien L; Chan, Teh-Sheng; Hicks, M John; Blackburn, Michael R; Kellems, Rodney E; Xia, Yang

    2015-02-24

    Preeclampsia is a prevalent hypertensive disorder of pregnancy and a leading cause of maternal and neonatal morbidity and mortality worldwide. This pathogenic condition is speculated to be caused by placental abnormalities that contribute to the maternal syndrome. However, the specific factors and signaling pathways that lead to impaired placentas and maternal disease development remain elusive. Using 2 independent animal models of preeclampsia (genetically engineered pregnant mice with elevated adenosine exclusively in placentas and a pathogenic autoantibody-induced preeclampsia mouse model), we demonstrated that chronically elevated placental adenosine was sufficient to induce hallmark features of preeclampsia, including hypertension, proteinuria, small fetuses, and impaired placental vasculature. Genetic and pharmacological approaches revealed that elevated placental adenosine coupled with excessive A₂B adenosine receptor (ADORA2B) signaling contributed to the development of these features of preeclampsia. Mechanistically, we provided both human and mouse evidence that elevated placental CD73 is a key enzyme causing increased placental adenosine, thereby contributing to preeclampsia. We determined that elevated placental adenosine signaling is a previously unrecognized pathogenic factor for preeclampsia. Moreover, our findings revealed the molecular basis underlying the elevation of placental adenosine and the detrimental role of excess placental adenosine in the pathophysiology of preeclampsia, and thereby, we highlight novel therapeutic targets. © 2014 American Heart Association, Inc.

  5. Extracellular Calcium and Magnesium in Preeclampsia and Eclampsia

    African Journals Online (AJOL)

    The cause of preeclampsia remains unknown and calcium and magnesium supplement are being suggested as means of prevention. The objective of this study was to assess magnesium and calcium in the plasma and cerebrospinal fluid of Nigerian women with preeclampsia and eclampsia. Setting was University of ...

  6. Periodontal disease and pre-eclampsia : a systematic review

    NARCIS (Netherlands)

    Kunnen, Alina; van Doormaal, Jasper J.; Abbas, Frank; Aarnoudse, Jan G.; van Pampus, Maria; Faas, Marijke M.

    2010-01-01

    P>Aim This review evaluates the possible relationship between periodontal disease and pre-eclampsia, a major pregnancy complication. A generalized inflammatory response plays an important role in the pathogenesis of pre-eclampsia. Because periodontal disease is a low-grade inflammatory state,

  7. Activation of peripheral leukocytes in rat pregnancy and experimental preeclampsia

    NARCIS (Netherlands)

    Faas, MM; Schuiling, GA; Linton, EA; Sargent, IL; Redman, CWG

    OBJECTIVE: The aim of this study was to search for activation markers of peripheral leukocytes in experimental preeclampsia in the rat. STUDY DESIGN: Experimental preeclampsia was induced in 14-day-pregnant rats by infusion of endotoxin (1.0 mu g/kg body weight). For comparison, rats with normal

  8. Monocytes and macrophages in pregnancy and pre-eclampsia

    NARCIS (Netherlands)

    Faas, Marijke M.; Spaans, Floor; De Vos, Paul

    2014-01-01

    Preeclampsia is an important complication in pregnancy, characterized by hypertension and proteinuria in the second half of pregnancy. Generalized activation of the inflammatory response is thought to play a role in the pathogenesis of pre-eclampsia. Monocytes may play a central role in this

  9. Prediction and primary prevention of pre-eclampsia

    NARCIS (Netherlands)

    Thangaratinam, Shakila; Langenveld, Josie; Mol, Ben W.; Khan, Khalid S.

    2011-01-01

    Pre-eclampsia is associated with increased maternal and perinatal mortality and morbidity. Early recognition of women at risk of pre-eclampsia will enable the identification of high-risk women who may benefit from enhanced surveillance and prophylaxis. In this chapter, we summarise the accuracy of

  10. Massive vulvar edema in a woman with severe preeclampsia. A ...

    African Journals Online (AJOL)

    We report a case of massive vulvar edema in a 20 years old primigravida woman with severe preeclampsia at 32 weeks gestation. Other causes of vulvar edema were excluded. The vulvar edema appeared as the blood pressure increased, and cesarean section was performed for increasing preeclampsia and fetal distress.

  11. Serum lipid levels in pregnancies complicated by preeclampsia

    Directory of Open Access Journals (Sweden)

    Valmir Jose de Lima

    Full Text Available CONTEXT AND OBJECTIVE: Pre-eclampsia is a disorder that occurs only during pregnancy. Postpartum changes relating to lipid metabolism may contribute towards the endothelial lesions observed in preeclampsia. Thus, the aim of the present study was to evaluate the lipid profile among patients who present preeclampsia and correlate these parameters with 24-hour proteinuria. DESIGN AND SETTING: Cross-sectional analytical study including 77 pregnant patients seen at Hospital Dório Silva. METHODS: This study involved 42 women with preeclampsia and 35 healthy pregnant women in the third trimester of pregnancy as controls. Blood samples were obtained from all the patients, and the serum levels of triglycerides, total cholesterol, low-density lipoproteins (LDL, high-density lipoproteins (HDL and very low density lipoproteins (VLDL were determined. Cases and controls were matched for maternal age, gestational week and body mass index. RESULTS: The VLDL and triglyceride values from the women with preeclampsia were significantly higher than those of the healthy women. There was a positive correlation between increased proteinuria and higher VLDL and triglyceride levels in patients with preeclampsia. CONCLUSION: Among the patients with preeclampsia, higher VLDL and triglyceride levels were positively correlated with proteinuria. These observations indicate that the pregnant women who presented elevated lipid levels were more susceptible to cardiovascular disorders and, consequently, pre-eclampsia.

  12. Sentimentos, representações e expectativas da gestante relativamente ao filho: estudo exploratório com uma amostra de gestantes do Centro Hospitalar Cova da Beira

    OpenAIRE

    Gonçalves, Carolina da Cruz

    2014-01-01

    Dissertação de mestrado em Psicologia do Desenvolvimento, apresentada à Faculdade de Psicologia e de Ciências da Educação da Universidade de Coimbra A presente investigação tem como objetivo geral estudar os sentimentos, as representações e as expectativas da gestante relativamente ao filho. Num plano mais específico, pretende-se estudar aspetos da vinculação pré-natal materna, através dos sentimentos que a mãe tem pelo bebé e da interação que estabelece com ele; explorar a importância da ...

  13. Elevated Ratio of Maternal Plasma ApoCIII to ApoCII in Preeclampsia

    Science.gov (United States)

    2011-05-01

    disease. Given the similarities in pathology, etiology , and clinical presentation between cardiovascular disease and preeclampsia , we hypothesized that...directed fetal/placental signals? In: Lyall F, Belfort M, eds. Preeclampsia : Etiology and Clinical Practice. Cambridge, UK: Cambridge University Press...2007:183-194. 3. Hubel C. Dyslipidemia and preeclampsia . In: Lyall F, Belfort M, eds. Preeclampsia : Etiology and Clinical Practice. Cambridge, UK

  14. Combined Screening for Early Detection of Pre-Eclampsia

    Directory of Open Access Journals (Sweden)

    Hee Jin Park

    2015-08-01

    Full Text Available Although the precise pathophysiology of pre-eclampsia remains unknown, this condition continues to be a major cause of maternal and fetal mortality. Early prediction of pre-eclampsia would allow for timely initiation of preventive therapy. A combination of biophysical and biochemical markers are superior to other tests for early prediction of the development of pre-eclampsia. Apart from the use of parameters in first-trimester aneuploidy screening, cell-free fetal DNA quantification is emerging as a promising marker for prediction of pre-eclampsia. This article reviews the current research of the most important strategies for prediction of pre-eclampsia, including the use of maternal risk factors, mean maternal arterial pressure, ultrasound parameters, and biomarkers.

  15. Preeclampsia Associates with Asthma, Allergy, and Eczema in Childhood

    DEFF Research Database (Denmark)

    Stokholm, Jakob; Sevelsted, Astrid; Anderson, Ulrik D

    2017-01-01

    RATIONALE: Preeclampsia reflects an unusual increase in systemic inflammation during pregnancy. OBJECTIVES: We studied associations between preeclampsia and asthma, allergy, and eczema in Copenhagen Prospective Studies on Asthma in Childhood2000 (COPSAC2000) and in national registries. METHODS....... The register-based cohort included 1.7 million children from Danish national registries in the 35-year period 1977-2012. Children born to mothers with preeclampsia were analyzed regarding risk of asthma, allergy, and eczema. MEASUREMENTS AND MAIN RESULTS: In the COPSAC2000 cohort, 5.6% (n = 23) were diagnosed...... with preeclampsia. Preeclampsia was associated with increased risk of treatment with inhaled corticosteroids at age 7 years (adjusted odds ratio, 4.01 [95% confidence interval (CI), 1.11-14.43]; P = 0.0337), increased bronchial responsiveness to methacholine (adjusted β-coefficient log-μmol, -0.80 [95% CI, -1...

  16. Dynamic Cerebral Autoregulation in Pregnancy and the Risk of Preeclampsia

    DEFF Research Database (Denmark)

    Janzarik, Wibke G; Ehlers, Elena; Ehmann, Renata

    2014-01-01

    Preeclampsia may affect severely the cerebral circulation leading to impairment of cerebral autoregulation, edema, and ischemia. It is not known whether impaired autoregulation occurs before the clinical onset of preeclampsia, and whether this can predict the occurrence of preeclampsia. Seventy......) of respiratory-induced 0.1 Hz hemodynamic oscillations. Uterine artery ultrasound was performed to search for a notch sign as an early marker of general endothelial dysfunction. All women were followed up until 6 weeks after delivery for the occurrence of preeclampsia. The autoregulation parameter gain did...... not differ between pregnant and nonpregnant women. Phase was slightly but significantly higher in pregnant women, indicating better DCA. Women with a notch sign did not show altered DCA. A history of preeclampsia during a previous pregnancy was associated with lower phase in middle cerebral artery...

  17. Low-Dose Aspirin for the Prevention of Preeclampsia.

    Science.gov (United States)

    Fantasia, Heidi Collins

    2018-02-01

    Preeclampsia is a hypertensive disorder specific to pregnancy that remains a significant cause of maternal and neonatal morbidity and mortality. Identification of women who are most at risk for preeclampsia is imprecise. Because of the potential negative health consequences of preeclampsia for women and newborns and the lack of effective screening mechanisms preventing preeclampsia is an important component of prenatal care. Researchers have documented that low-dose aspirin, taken daily after the first trimester, can decrease the development of preeclampsia and reduce the incidence of preterm birth and birth of small-for-gestational-age infants. This column includes an overview of low-dose aspirin in pregnancy and a review of current recommendations from leading national organizations. © 2018 AWHONN, the Association of Women’s Health, Obstetric and Neonatal Nurses.

  18. IFPA Senior Award Lecture: making sense of pre-eclampsia - two placental causes of preeclampsia?

    Science.gov (United States)

    Redman, C W; Sargent, I L; Staff, A C

    2014-02-01

    Incomplete spiral artery remodelling is the first of two stages of pre-eclampsia, typically of early onset. The second stage comprises dysregulated uteroplacental perfusion and placental oxidative stress. Oxidatively stressed syncytiotrophoblast (STB) over-secretes proteins that perturb maternal angiogenic balance and are considered to be pre-eclampsia biomarkers. We propose that, in addition and more fundamentally, these STB-derived proteins are biomarkers of a cellular (STB) stress response, which typically involves up-regulation of some proteins and down-regulation of others (positive and negative stress proteins respectively). Soluble vascular growth factor receptor-1 (sVEGFR-1) and reduced growth factor (PlGF) then exemplify positive and negative STB stress response proteins in the maternal circulation. Uncomplicated term pregnancy is associated with increasing sVEGFR-1 and decreasing PlGF, which can be interpreted as evidence of increasing STB stress. STB pathology, at or after term (for example focal STB necrosis) demonstrates this stress, with or without pre-eclampsia. We review the evidence that when placental growth reaches its limits at term, terminal villi become over-crowded with diminished intervillous pore size impeding intervillous perfusion with increasing intervillous hypoxia and STB stress. This type of STB stress has no antecedent pathology, so the fetuses are well-grown, as typifies late onset pre-eclampsia, and prediction is less effective than for the early onset syndrome because STB stress is a late event. In summary, abnormal placental perfusion and STB stress contribute to the pathogenesis of early and late onset pre-eclampsia. But the former has an extrinsic cause - poor placentation, whereas the latter has an intrinsic cause, 'microvillous overcrowding', as placental growth reaches its functional limits. This model explains important features of late pre-eclampsia and raises questions of how antecedent medical risk factors such as

  19. Accuracy of simple urine tests for diagnosis of urinary tract infections in low-risk pregnant women La exactitud del examen de orina simple para diagnosticar infecciones del tracto urinario en gestantes de bajo riesgo Acurácia do exame de urina simples para diagnóstico de infecções do trato urinário em gestantes de baixo risco

    Directory of Open Access Journals (Sweden)

    Danielle Cristina Alves Feitosa

    2009-08-01

    Full Text Available Anatomic and physiological alterations during pregnancy predispose pregnant women to urinary tract infections (UTI. This study aimed to identify the accuracy of the simple urine test for UTI diagnosis in low-risk pregnant women. Diagnostic test performance was conducted in Botucatu, SP, involving 230 pregnant women, between 2006 and 2008. Results showed 10% UTI prevalence. Sensitivity, specificity and accuracy of the simple urine test were 95.6%, 63.3% and 66.5%, respectively, in relation to UTI diagnoses. The analysis of positive (PPV and negative (NPV predictive values showed that, when a regular simple urine test was performed, the chance of UTI occurrence was small (NPV 99.2%. In view of an altered result for such a test, the possibility of UTI existence was small (PPV 22.4%. It was concluded that the accuracy of the simple urine test as a diagnostic means for UTI was low, and that performing a urine culture is essential for appropriate diagnosis.Las alteraciones anatómicas y fisiológicas de la gravidez predisponen a las gestantes a infecciones del tracto urinario (ITU. El objetivo de este estudio fue identificar la exactitud del examen de orina simple para diagnosticar ITU en gestantes de bajo riesgo. Se hizo uso del estudio de desempeño de prueba de diagnóstico realizado en Botucatu, San Pablo, con 230 gestantes, entre 2006 y 2008. Los resultados muestran que la prevalencia de ITU fue de 10%. La sensibilidad fue 95,6%, la especificidad 63,3% y la exactitud 66,5% del examen de orina simple, en relación al diagnóstico de ITU. El análisis de los valores de predicción positivo y negativo (VPP y VPN mostró que, en la vigencia de examen de orina simple normal, la probabilidad de haber ITU fue pequeña (VPN 99,2%. Frente al resultado alterado de ese examen, la probabilidad de haber ITU fue baja (VPP 22,4%. Se concluye que la exactitud del examen de orina simple como medio de diagnóstico de ITU fue baja, siendo indispensable la realizaci

  20. Platelet count and platelet indices in women with preeclampsia.

    Science.gov (United States)

    AlSheeha, Muneera A; Alaboudi, Rafi S; Alghasham, Mohammad A; Iqbal, Javed; Adam, Ishag

    2016-01-01

    Although the exact pathophysiology of preeclampsia is not completely understood, the utility of different platelets indices can be utilized to predict preeclampsia. To compare platelet indices, namely platelet count (PC), mean platelet volume (MPV), platelet distribution width (PDW), and PC to MPV ratio in women with preeclampsia compared with healthy controls. Qassim Hospital, Kingdom of Saudi Arabia. A case-control study. Sixty preeclamptic women were the cases and an equal number of healthy pregnant women were the controls. There was no significant difference in age, parity, and body mass index between the study groups. Sixteen and 44 of the cases were severe and mild preeclampsia, respectively. There was no significant difference in PDW and MPV between the preeclamptic and control women. Both PC and PC to MPV ratios were significantly lower in the women with preeclampsia compared with the controls. There was no significant difference in the PC, PDW, MPV, and PC to MPV ratio when women with mild and severe preeclampsia were compared. Using receiver operating characteristic (ROC) curves, the PC cutoff was 248.0×10 3 /µL for diagnosis of pre-eclampsia ( P =0.019; the area under the ROC curve was 62.4%). Binary regression suggests that women with PC preeclampsia (odds ratio =2.2, 95% confidence interval =1.08-4.6, P =0.03). The PC/MPV cutoff was 31.2 for diagnosis of preeclampsia ( P =0.035, the area under the ROC curve was 62.2%). PC preeclampsia.

  1. Early pregnancy vitamin D status and risk of preeclampsia.

    Science.gov (United States)

    Mirzakhani, Hooman; Litonjua, Augusto A; McElrath, Thomas F; O'Connor, George; Lee-Parritz, Aviva; Iverson, Ronald; Macones, George; Strunk, Robert C; Bacharier, Leonard B; Zeiger, Robert; Hollis, Bruce W; Handy, Diane E; Sharma, Amitabh; Laranjo, Nancy; Carey, Vincent; Qiu, Weilliang; Santolini, Marc; Liu, Shikang; Chhabra, Divya; Enquobahrie, Daniel A; Williams, Michelle A; Loscalzo, Joseph; Weiss, Scott T

    2016-12-01

    Low vitamin D status in pregnancy was proposed as a risk factor of preeclampsia. We assessed the effect of vitamin D supplementation (4,400 vs. 400 IU/day), initiated early in pregnancy (10-18 weeks), on the development of preeclampsia. The effects of serum vitamin D (25-hydroxyvitamin D [25OHD]) levels on preeclampsia incidence at trial entry and in the third trimester (32-38 weeks) were studied. We also conducted a nested case-control study of 157 women to investigate peripheral blood vitamin D-associated gene expression profiles at 10 to 18 weeks in 47 participants who developed preeclampsia. Of 881 women randomized, outcome data were available for 816, with 67 (8.2%) developing preeclampsia. There was no significant difference between treatment (N = 408) or control (N = 408) groups in the incidence of preeclampsia (8.08% vs. 8.33%, respectively; relative risk: 0.97; 95% CI, 0.61-1.53). However, in a cohort analysis and after adjustment for confounders, a significant effect of sufficient vitamin D status (25OHD ≥30 ng/ml) was observed in both early and late pregnancy compared with insufficient levels (25OHD preeclampsia (FDR preeclampsia incidence in the intention-to-treat paradigm. However, vitamin D levels of 30 ng/ml or higher at trial entry and in late pregnancy were associated with a lower risk of preeclampsia. Differentially expressed vitamin D-associated transcriptomes implicated the emergence of an early pregnancy, distinctive immune response in women who went on to develop preeclampsia. ClinicalTrials.gov NCT00920621. Quebec Breast Cancer Foundation and Genome Canada Innovation Network. This trial was funded by the National Heart, Lung, and Blood Institute. For details see Acknowledgments.

  2. Serum 8-isoprostane increased in pre-eclampsia

    Directory of Open Access Journals (Sweden)

    Besari Adi Pramono

    2012-04-01

    Full Text Available Background The main causes of maternal mortality in Indonesia are pre-eclampsia, hemorrhage, and infection. Oxidative stress has a primary role in pre-eclampsia and one of its parameters is 8-isoprostane serum level. The objective of this study is to measure 8-isoprostane and to analyze the relationship between 8-isoprostane level and birth weight in pre-eclampsia. Methods A cross-sectional study involving 23 pre-eclampsia and 29 normotensive pregnant women with normal or cesarean delivery at Dr. Kariadi Hospital Semarang from January to May 2011. Collected maternal blood samples were assessed for 8-Isoprostane levels by means of a specific ELISA kit. Neonatal birth weight was measured immediately after delivery by means of calibrated baby scales. Differences in 8-isoprostane levels between pre-eclampsia and normotensive women were assessed using independent t-test for normal distributed data, and the Mann-Whitney test for non-normally distributed data. Results Mean 8-isoprostane level was significantly higher in women with pre-eclampsia than in normotensive women (62.52 ± 12.19 pg/mL vs 28.64 ± 8.81 pg/mL (p<0.05. Low birth weight was twice as frequent in pre-eclampsia than in normotensives. There was no correlation between 8-isoprostane serum level and neonatal birth weight in pre-eclampsia. Conclusion The level of 8-isoprostane was higher in pre-eclampsia than in normotensives. It is recommended to conduct further studies to determine whether 8-isoprostane may be used as a predictive marker of pre-eclampsia.

  3. Genetic Predisposition to Dyslipidemia and Risk of Preeclampsia.

    Science.gov (United States)

    Spracklen, Cassandra N; Saftlas, Audrey F; Triche, Elizabeth W; Bjonnes, Andrew; Keating, Brendan; Saxena, Richa; Breheny, Patrick J; Dewan, Andrew T; Robinson, Jennifer G; Hoh, Josephine; Ryckman, Kelli K

    2015-07-01

    Large epidemiologic studies support the role of dyslipidemia in preeclampsia; however, the etiology of preeclampsia or whether dyslipidemia plays a causal role remains unclear. We examined the association between the genetic predisposition to dyslipidemia and risk of preeclampsia using validated genetic markers of dyslipidemia. Preeclampsia cases (n = 164) and normotensive controls (n = 110) were selected from live birth certificates to nulliparous Iowa women during the period August 2002 to May 2005. Disease status was verified by medical chart review. Genetic predisposition to dyslipidemia was estimated by 4 genetic risk scores (GRS) (total cholesterol (TC), LDL cholesterol (LDL-C), HDL cholesterol (HDL-C), and triglycerides) on the basis of established loci for blood lipids. Logistic regression analyses were used to evaluate the relationships between each of the 4 genotype scores and preeclampsia. Replication analyses were performed in an independent, US population of preeclampsia cases (n = 516) and controls (n = 1,097) of European ancestry. The GRS related to higher levels of TC, LDL-C, and triglycerides demonstrated no association with the risk of preeclampsia in either the Iowa or replication population. The GRS related to lower HDL-C was marginally associated with an increased risk for preeclampsia (odds ratio (OR) = 1.03, 95% confidence interval (CI) = 0.99-1.07; P = 0.10). In the independent replication population, the association with the HDL-C GRS was also marginally significant (OR = 1.03, 95% CI: 1.00-1.06; P = 0.04). Our data suggest a potential effect between the genetic predisposition to dyslipidemic levels of HDL-C and an increased risk of preeclampsia, and, as such, suggest that dyslipidemia may be a component along the causal pathway to preeclampsia. © American Journal of Hypertension, Ltd 2014. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  4. Caracterización de la anemia durante el embarazo y algunos factores de riesgo asociados, en gestantes del municipio regla

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    Clara Irania San Gil Suárez

    Full Text Available Introducción: la anemia como problema mundial constituye un indicador general de pobre salud. En Latinoamérica la anemia ferripriva afecta a los grupos vulnerables como las embarazadas. Cuba no está exenta de esta carencia nutricional y su prevalencia alcanza el 25 % de las embarazadas. Objetivo: caracterizar la anemia durante la gestación y su relación con posibles factores asociados. Métodos: se realizó un estudio observacional, descriptivo y de corte transversal en 68 gestantes entre 28 y 32 semanas del Policlínico Lidia y Clodomiro, en el período de octubre a noviembre de 2010. Se aplicó una encuesta con datos sociodemográficos, antecedentes obstétricos y del embarazo actual y se determinó la hemoglobina. Resultados: se observó una disminución de los valores medios de hemoglobina entre el primer trimestre (112 g/L y el tercero (108 g/L. También se constató una alta frecuencia de anemia tanto en el primer trimestre (35,3 % como en el tercer trimestre del embarazo (56,0%, con una anemia moderada más alta. La anemia al inicio del embarazo resultó un factor de riesgo (ρ=0,02 de la existencia de anemia al tercer trimestre. Conclusiones: existió una alta frecuencia de anemia, siendo la anemia moderada la más frecuente, tanto en el primer trimestre como en el tercer trimestre de las embarazadas estudiadas. La anemia al inicio del embarazo resultó ser el factor de riesgo más importante encontrado en nuestro estudio a la existencia de anemia en el tercer trimestre, con independencia de otros posibles factores involucrados.

  5. Abordagem do enfermeiro no grupo educativo com gestantes candidatas à laqueadura

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    Arlete de Souza Barros

    1993-06-01

    Full Text Available Enfocamos neste trabalho a abordagem do enfermeiro enquanto coordenador de grupo educativo com gestantes candidatas à laqueadura. Enfatizamos a necessidade de um referencial teórico específico para trabalharmos com grupos de pacientes. Queremos evidenciar também o papel de educador inerente ao enfermeiro e a importância da sua atuação na equipe multiprofissional da área de saúde. A metodologia do grupo educativo é suscintamente descrita, na forma de um protocolo, que apresentamos como sugestão para o desenvolvimento de atividades semelhantes.

  6. Suspected acute toxoplasmosis in pregnant women Suspeita de toxoplasmose aguda em gestantes

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    Marcela Peres Castilho-Pelloso

    2007-02-01

    Full Text Available OBJECTIVE: To determine the prevalence of reagent serology for suspected acute toxoplasmosis in pregnant women and to describe clinical, laboratory and therapeutic profiles of mothers and their children. METHODS: A retrospective study was conducted with IgM-anti-Toxoplasma gondii-reagent pregnant women and their children who attended the public health system in the state of Paraná, Southern Brazil, from January 2001 to December 2003. Information were obtained from clinical, laboratory (ELISA IgM/IgG and ultrasonographic data and from interviews with the mothers. To test the homogeneity of the IgM indices in relation to the treatment used, the Pearson's Chi-square test was applied. Comparisons were considered significant at a 5% level. RESULTS: Two hundred and ninety (1.0% cases of suspected IgM-reagent infection were documented, with a prevalence of 10.7 IgM-reagent women per 1,000 births. Prenatal care started within the first 12 weeks for 214/290; 146/204 were asymptomatic. Frequent complaints included headaches, visual disturbance and myalgia. Ultrasonography revealed abnormalities in 13 of 204 pregnancies. Chemoprophylaxis was administered to 112/227; a single ELISA test supported most decisions to begin treatment. Pregnant women with IgM indices =2.000 tended to be treated more often. Among exposed children, 44/208 were serologically followed up and all were IgG-reagent, and three IgM-reagent cases showed clinical symptoms. CONCLUSIONS: The existence of pregnant women with laboratorially suspected acute toxoplasmosis who were not properly followed up, and of fetuses that were not adequately monitored, shows that basic aspects of the prenatal care are not being systematically observed. There is need of implementing a surveillance system of pregnant women and their children exposed to T. gondii.OBJETIVO: Determinar a prevalência de gestantes com sorologia reagente suspeita de toxoplasmose aguda e descrever as variáveis maternas e do

  7. Representações sociais de gestantes sobre saúde bucal

    OpenAIRE

    Finkler, Mirelle

    2003-01-01

    Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde. Programa de Pós-Graduação em Odontologia. Partindo do pressuposto de que é necessário melhor entender para melhor agir, este estudo investigou os saberes de gestantes sobre saúde bucal, tendo como objetivo a compreensão das representações sociais (RS) que influenciam suas práticas, à luz da Teoria das Representações Sociais, proposta por Moscovici, em 1961. Os sujeitos desta pesquisa qualitativa f...

  8. Percepções de gestantes negras com HIV sobre a discriminação racial e de soropositivade

    OpenAIRE

    Agnês Raquel Camisão Silva

    2013-01-01

    Resumo: O objetivo deste estudo foi compreender as vivências e significados da discriminação racial e soropositividade para gestantes negras com HIV. Foram objetivos específicos verificar na literatura brasileira atual as discriminações vivenciadas pela mulher; conhecer como preconceitos relativos à discriminação racial e à soropositividade são vivenciados e identificar os significados da discriminação racial e da soropositividade para estas gestantes. Inicialmente foi realizada uma revisão i...

  9. The Relevance of the Renin-Angiotensin System in the Development of Drugs to Combat Preeclampsia

    OpenAIRE

    Ueki, Norikazu; Takeda, Satoru; Koya, Daisuke; Kanasaki, Keizo

    2015-01-01

    Preeclampsia is a hypertensive disorder that occurs during pregnancy. It has an unknown etiology and affects approximately 5?8% of pregnancies worldwide. The pathophysiology of preeclampsia is not yet known, and preeclampsia has been called ?a disease of theories.? The central symptom of preeclampsia is hypertension. However, the etiology of the hypertension is unknown. In this review, we analyze the molecular mechanisms of preeclampsia with a particular focus on the pathogenesis of the hyper...

  10. Seasonal variation in the prevalence of preeclampsia

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    Fatemeh Janani

    2017-01-01

    Full Text Available Introduction: Hypertension in pregnancy is one of the three factors of maternal mortality. Etiology of the disease is unknown, but the many factors contributing to the identification and control of it can be taken a step to prevent and reduce the symptoms of the disease. The purpose of this study was to determine the prevalence of preeclampsia (high-blood pressure in different seasons of the year. Methods: The present retrospective cross-sectional study was conducted on more than 8,000 pregnant women visiting Assali specialized hospital from 2011 to 2013. Required data was collected through questionnaire checklist. The Chi-square test with multiple comparisons was used to compare the frequencies of pregnancy-induced hypertension (PIH according to the month of year, and adjustment of multiplicity was conducted using Bonferroni's method. Student's t-test was used to compare the means of PIH prevalence rates. In all analyses, P < 0.05 was taken to indicate statistical significance. Results: In these 8000 woman admitted to labor, overall prevalence of PIH was 3.8 ± 0.6%. The prevalence rate of PIH was highest in the summer (4.5% and lowest frequent in the winter (2.7%, respectively. In July, the prevalence rate was significantly higher than those for any other month (4.7%, and in March, it was lower prevalence than for any month (2.2%, respectively. Using the Chi-square test, a significant difference between the incidence of disease was observed in summer and winter (P < 0.001. Conclusion: The prevalence rate of PIH was higher for delivery in summer and early spring and lowest for winter delivery among Khorramabad women based on these results; it seems that changes in temperature and humidity in different seasons can affect preeclampsia, and preeclampsia increases with increasing frequency temperature.

  11. Endothelial dysfunction in pre-eclampsia

    OpenAIRE

    Pacheco Romero, José

    2013-01-01

    Desconocemos aún la etiología de la preeclampsia, pero ahora sabemos que no es sólo una hipertensión inducida por el embarazo, sino que existe interacción entre una perfusión placentaria disminuida y la alteración en la función endotelial materna, probablemente por razones inmunológicas de rechazo parcial a la placentación normal. La contribución materna es de factores que anteceden al embarazo, influenciados por las adaptaciones metabólicas usuales. No existe un gen único que pueda explicar ...

  12. RAS in Pregnancy and Preeclampsia and Eclampsia

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    M. Rodriguez

    2012-01-01

    Full Text Available Preeclampsia is a common disease of pregnancy characterized by the presence of hypertension and commitment of many organs, including the brain, secondary to generalized endothelial dysfunction. Its etiology is not known precisely, but it involved several factors, highlighting the renin angiotensin system (RAS, which would have an important role in the origin of multisystem involvement. This paper reviews the evidence supporting the involvement of RAS in triggering the disease, in addition to the components of this system that would be involved and how it eventually produces brain engagement.

  13. Relationship between insulin resistance and tissue blood flow in preeclampsia.

    Science.gov (United States)

    Anim-Nyame, Nick; Gamble, John; Sooranna, Suren R; Johnson, Mark R; Steer, Philip J

    2015-05-01

    Preeclampsia is characterized by generalized endothelial dysfunction and impaired maternal tissue perfusion, and insulin resistance is a prominent feature of this disease. The aim of this study was to test the hypothesis that insulin resistance in preeclampsia is related to the reduced resting tissue blood flow. We used venous occlusion plethysmography to compare the resting calf muscle blood flow (measured as QaU) in 20 nulliparous women with preeclampsia and 20 normal pregnant controls matched for maternal age, gestational age, parity and BMI during the third trimester. Fasting blood samples were obtained to measure the plasma concentrations of insulin and glucose, and to calculate the fasting insulin resistance index (FIRI), a measure of insulin resistance in both groups of women. Calf blood flow was significantly reduced in the preeclampsia group (1.93 ± 0.86 QaU), compared with normal pregnant controls (3.94 ± 1.1 QaU, P insulin concentrations and Insulin Resistance Index were significantly higher in preeclampsia compared with normal pregnancy (P insulin concentrations (r = -0.57, P = 0.008) and FIRI (r = -0.59, P = 0.006) in preeclampsia, but not in normal pregnancy. These findings support our hypothesis and raise the possibility that reduced tissue blood flow may a play a role in the increased insulin resistance seen in preeclampsia.

  14. Chocolate consumption in pregnancy and reduced likelihood of preeclampsia.

    Science.gov (United States)

    Triche, Elizabeth W; Grosso, Laura M; Belanger, Kathleen; Darefsky, Amy S; Benowitz, Neal L; Bracken, Michael B

    2008-05-01

    Preeclampsia is a major pregnancy complication with cardiovascular manifestations. Recent studies suggest that chocolate consumption may benefit cardiovascular health. We studied the association of chocolate consumption with risk of preeclampsia in a prospective cohort study of 2291 pregnant women who delivered a singleton livebirth between September 1996 and January 2000. Chocolate consumption was measured by self report in the first and third trimesters, and by umbilical cord serum concentrations of theobromine, the major methylxanthine component of chocolate. Preeclampsia was assessed by detailed medical record review for 1943 of the women. We derived adjusted odds ratios (aOR) and 95% confidence intervals (CIs) from logistic regression models controlling for potential confounders. Preeclampsia developed in 3.7% (n = 63) of 1681 women. Cord serum theobromine concentrations were negatively associated with preeclampsia (aOR = 0.31; CI = 0.11-0.87 for highest compared with lowest quartile). Self-reported chocolate consumption estimates also were inversely associated with preeclampsia. Compared with women consuming under 1 serving of chocolate weekly, women consuming 5+ servings per week had decreased risk: aOR = 0.81 with consumption in the first 3 months of pregnancy (CI = 0.37-1.79) and 0.60 in the last 3 months (0.30-1.24). Our results suggest that chocolate consumption during pregnancy may lower risk of preeclampsia. However, reverse causality may also contribute to these findings.

  15. Maternal serum theobromine and the development of preeclampsia.

    Science.gov (United States)

    Klebanoff, Mark A; Zhang, Jun; Zhang, Cuilin; Levine, Richard J

    2009-09-01

    Preeclampsia, a disorder with prominent cardiovascular manifestations, is a cause of maternal, fetal, and infant morbidity and mortality. Chocolate contains compounds that may promote cardiovascular health. A recent study found chocolate consumption during pregnancy, and, particularly, increasing cord serum concentration of theobromine (the primary methylxanthine alkaloid in chocolate), to be associated with reduced occurrence of preeclampsia. We studied 2769 women who comprised the control group from a case-control study of caffeine metabolites and spontaneous abortion nested within the Collaborative Perinatal Project. These women were pregnant between 1959 and 1966, with liveborn infants of at least 28 weeks' gestation. Serum was drawn at 26 weeks' gestation, and assayed for theobromine by high-performance liquid chromatography. Odds ratios (ORs) for preeclampsia were estimated using logistic regression, and adjusted for age, education, prepregnant weight, race, parity, smoking, and gestation at blood draw. Preeclampsia occurred in 68 (2.9%) of 2105 eligible women. Adjusted ORs for preeclampsia were near unity across most third-trimester theobromine concentrations. Adjusted ORs for preeclampsia according to theobromine concentration in serum at theobromine and preeclampsia.

  16. Vitamina A en gestantes evaluadas mediante encuesta dietética e impresión citológica conjuntival

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    Jesús Diego de la Campa

    1996-06-01

    Full Text Available Se realizó un estudio descriptivo de carácter prospectivo longitudinal con el fin de establecer el status de vitamina A de las gestantes del Policlínico "Dr. Joaquín Albarrán" mediante una encuesta dietética y citología de impresión conjuntival; se tomó como universo la totalidad de las embarazadas captadas en el primer trimestre de 1994 (71 pacientes, a las que se aplicó el formulario de la encuesta, se les tomó una muestra citológica conjuntival entre las 8 y las 12 semanas de gestación, y se les determinó el peso y la talla. Igual procedimiento se repitió entre las 28 y las 32 semanas. Encontramos alteración de la citología conjuntival en una paciente al tomar la primera muestra para el 1,4 %. No hubo alteraciones conjuntivales en la segunda muestra (la gestante que presentó anomalías citológicas conjuntivales en la primera muestra, consumía limitadamente alimentos ricos en vitamina A, fue suplementada con el neovitamín II, cuando se tomó la segunda muestra ya había recobrado el patrón normal, lo que demuestra que no existe déficit de vitamina A como problema nutricional en las gestantes de nuestra área de salud en el grupo evaluado. Los resultados del estudio indican que aunque en las encuestas dietéticas se registran moderadas frecuencias de consumo de alimentos ricos en vitamina A, no se detectan deficiencias a nivel de órgano efector, ello posiblemente se deba a que la suma de los aportes alimentarios, más las dosificaciones que tienen los suplementos vitamínicos, satisfacen el nivel de seguridad de mantenimiento de reservas hepáticas, y por lo tanto, proveen la vitamina A más allá del umbral donde aparecen los signos de carencias.A descriptive study of longitudinal prospective character was carried out aimed at establishing the vitamin A status of pregnant women at the "Dr. Joaquín Albarrán" Polyclinic by means of a dietetic survey and a conjunctival impression cytology. All pregnant women treated

  17. Inherited predisposition to preeclampsia: Analysis of the Aberdeen intergenerational cohort.

    Science.gov (United States)

    Ayorinde, Abimbola A; Bhattacharya, Sohinee

    2017-04-01

    To assess the magnitude of familial risk of preeclampsia and gestational hypertension in women born of a preeclamptic pregnancy and those born of pregnancy complicated by gestational hypertension while accounting for other risk factors. An intergenerational dataset was extracted from the Aberdeen Maternity and Neonatal Databank (AMND) which records all pregnancy and delivery details occurring in Aberdeen, Scotland since 1950. The analysis included all nulliparous women whose mothers' records at their births are also recorded in the AMND. Multinomial logistic regression was used to assess the risk of having preeclampsia or gestational hypertension based on maternal history of preeclampsia or gestational hypertension. There were 17302 nulliparous women included, of whom 1057(6.1%) had preeclampsia while 4098(23.7%) had gestational hypertension. Furthermore, 424(2.5%) and 2940(17.0%) had maternal history of preeclampsia and gestational hypertension respectively. The risk of preeclampsia was higher in women who were born of pregnancies complicated by preeclampsia (adjusted RRR 2.55 95% CI 1.87-3.47). This was higher than the risk observed in women whose mothers had gestational hypertension (adjusted RRR 1.44 95% CI 1.23-1.69). Conversely, the risk of gestational hypertension was similar in those who were born of preeclamptic pregnancies (adjusted RRR 1.37 95% CI 1.09-1.71) and those whose mothers had gestational hypertension (adjusted RRR 1.36 95% CI 1.24-1.49). There was a dose response effect in the inheritance pattern of preeclampsia with the highest risk in women born of preeclamptic pregnancies. Gestational hypertension showed similar increased risk with maternal gestational hypertension and preeclampsia. Copyright © 2017 International Society for the Study of Hypertension in Pregnancy. Published by Elsevier B.V. All rights reserved.

  18. Genetic Risk Score for Essential Hypertension and Risk of Preeclampsia.

    Science.gov (United States)

    Smith, Caitlin J; Saftlas, Audrey F; Spracklen, Cassandra N; Triche, Elizabeth W; Bjonnes, Andrew; Keating, Brendan; Saxena, Richa; Breheny, Patrick J; Dewan, Andrew T; Robinson, Jennifer G; Hoh, Josephine; Ryckman, Kelli K

    2016-01-01

    Preeclampsia is a hypertensive complication of pregnancy characterized by novel onset of hypertension after 20 weeks gestation, accompanied by proteinuria. Epidemiological evidence suggests that genetic susceptibility exists for preeclampsia; however, whether preeclampsia is the result of underlying genetic risk for essential hypertension has yet to be investigated. Based on the hypertensive state that is characteristic of preeclampsia, we aimed to determine if established genetic risk scores (GRSs) for hypertension and blood pressure are associated with preeclampsia. Subjects consisted of 162 preeclamptic cases and 108 normotensive pregnant controls, all of Iowa residence. Subjects' DNA was extracted from buccal swab samples and genotyped on the Affymetrix Genome-wide Human SNP Array 6.0 (Affymetrix, Santa Clara, CA). Missing genotypes were imputed using MaCH and Minimac software. GRSs were calculated for hypertension, systolic blood pressure (SBP), diastolic blood pressure (DBP), and mean arterial pressure (MAP) using established genetic risk loci for each outcome. Regression analyses were performed to determine the association between GRS and risk of preeclampsia. These analyses were replicated in an independent US population of 516 cases and 1,097 controls of European ancestry. GRSs for hypertension, SBP, DBP, and MAP were not significantly associated with risk for preeclampsia (P > 0.189). The results of the replication analysis also yielded nonsignificant associations. GRSs for hypertension and blood pressure are not associated with preeclampsia, suggesting that an underlying predisposition to essential hypertension is not on the causal pathway of preeclampsia. © American Journal of Hypertension, Ltd 2015. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  19. Baixa autoestima situacional em gestantes: uma análise de acurácia

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    Joyce Carolle Bezerra Cavalcante

    Full Text Available Para investigar a acurácia de características definidoras do diagnóstico Baixa autoestima situacional, realizou-se um estudo transversal, com 52 gestantes atendidas num centro de atendimento familiar. Utilizou-se a taxonomia da NANDA-I e a escala de Rosenberg. O diagnóstico esteve presente em 32,7% das gestantes e todas as características apresentaram associação estatística com o diagnóstico, exceto "Relata verbalmente desafio situacional ao seu próprio valor". As características com maior sensibilidade foram "Comportamento indeciso" e "Expressões de desamparo" (82,35%. Já as características "Expressões de sentimento de inutilidade" e "Relata verbalmente desafio situacional atual ao seu próprio valor" apresentaram maior especificidade (94,29%. Tais resultados podem contribuir com a prática de enfermagem, pois a identificação de características acuradas é fundamental para uma inferência segura.

  20. Baixa autoestima situacional em gestantes: uma análise de acurácia

    Directory of Open Access Journals (Sweden)

    Joyce Carolle Bezerra Cavalcante

    2012-12-01

    Full Text Available Para investigar a acurácia de características definidoras do diagnóstico Baixa autoestima situacional, realizou-se um estudo transversal, com 52 gestantes atendidas num centro de atendimento familiar. Utilizou-se a taxonomia da NANDA-I e a escala de Rosenberg. O diagnóstico esteve presente em 32,7% das gestantes e todas as características apresentaram associação estatística com o diagnóstico, exceto "Relata verbalmente desafio situacional ao seu próprio valor". As características com maior sensibilidade foram "Comportamento indeciso" e "Expressões de desamparo" (82,35%. Já as características "Expressões de sentimento de inutilidade" e "Relata verbalmente desafio situacional atual ao seu próprio valor" apresentaram maior especificidade (94,29%. Tais resultados podem contribuir com a prática de enfermagem, pois a identificação de características acuradas é fundamental para uma inferência segura.

  1. Ethical issues related to screening for preeclampsia.

    Science.gov (United States)

    Jørgensen, Jennifer M; Hedley, Paula L; Gjerris, Mickey; Christiansen, Michael

    2014-09-01

    The implementation of new methods of treating and preventing disease raises many question of both technical and moral character. Currently, many studies focus on developing a screening test for preeclampsia (PE), a disease complicating 2-8% of pregnancies, potentially causing severe consequences for pregnant women and their fetuses. The purpose is to develop a test that can identify pregnancies at high risk for developing PE sufficiently early in pregnancy to allow for prophylaxis. However, the question of implementing a screening test for PE does not only involve an evaluation of technical feasibility and clinical efficacy, it also requires an analysis of how the test influences the conditions and choices for those tested. This study evaluates state-of-the-art techniques for preeclampsia screening in an ethical framework, pointing out the central areas of moral relevance within the context of such screening activity. Furthermore, we propose ethical guidelines that a screening programme for PE should meet in order to become an uncontroversial addition to prenatal health care. © 2012 John Wiley & Sons Ltd.

  2. Placental Abnormalities and Preeclampsia in Trisomy 13 Pregnancies

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    Chih-Ping Chen

    2009-03-01

    Full Text Available Women who are carrying a trisomy 13 fetus are prone to have an abnormal placenta as well as to develop preeclampsia in the second and third trimesters. This article provides a comprehensive review of placental abnormalities, such as small placental volume, reduced placental vascularization, a partial molar appearance of the placenta and placental mesenchymal dysplasia, and preeclampsia associated with trisomy 13 pregnancies. The candidate preeclampsia-causing genes on chromosome 13, such as sFlt1, COL4A2 and periostin, are discussed.

  3. The Effects of Vitamin D Supplement on Prevention of Recurrence of Preeclampsia in Pregnant Women with a History of Preeclampsia

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    Sanam Behjat Sasan

    2017-01-01

    Full Text Available Introduction. Preeclampsia is a pregnancy-specific syndrome. One of the hypotheses concerning the etiology of preeclampsia is vitamin D deficiency during pregnancy. Method and Materials. The present study is a randomized controlled clinical trial which aims to determine the effect of vitamin D supplement on reducing the probability of recurrent preeclampsia. 72 patients were placed in control group while 70 patients were randomized to the intervention group. The intervention group received a 50000 IU pearl vitamin D3 once every two weeks. The control group was administered placebo. Vitamin D or placebo was given until the 36th week of pregnancy. Results. The patients in intervention group have significantly lower (P value = 0.036 probability of preeclampsia than patients in the control group. The risk of preeclampsia for the control group was 1.94 times higher than that for the intervention group (95% CI 1.02, 3.71. Conclusion. The intended intervention (i.e., prescription of vitamin D has a protective effect against recurrent preeclampsia. Vitamin D supplementation therapy in pregnancy could help in reducing the incidence of gestational hypertension/preeclampsia. Registration. This study has been registered in Iranian Registry of Clinical Trials (IRCT site with ID number IRCT2017010131695N1.

  4. Uso de medicamentos entre gestantes de um município no sul de Minas Gerais, Brasil

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    Vinícius Miranda BORGES

    2018-04-01

    Full Text Available Neste estudo transversal, por meio de entrevistas domiciliares, foi mostrado o perfil farmacoterapêutico de gestantes atendidas pelo Sistema Único de Saúde (SUS durante o pré-natal, sendo que os medicamentos utilizados foram classificados segundo critérios de risco do Food and Drug Administration (FDA. Entre as 104 gestantes entrevistadas, 94,2% utilizavam medicamento e foram identificadas 53 especialidades farmacêuticas no total de 316 medicamentos (média de 3 medicamentos por gestante. A frequência de medicamentos do grupo A (n = 115, 36,4% foi próxima ao B (n = 121, 38,3%, 3 vezes maior que o C (n = 36, 11,4% e 4 que o D (n = 29, 9,2%. 22,1% (IC(95% 14,4 - 29,8 das entrevistadas utilizavam medicações da classe D e 1,9% da X. Houve uma positiva e significativa correlação entre a idade gestacional e uso de medicação, com 60,1% dos medicamentos sendo consumidos no terceiro trimestre, e 56,7% das gestantes utilizando-os neste período. As classes terapêuticas mais consumidas foram: vitaminas/suplementos minerais/preparações anti-anêmicas (35.33% dos 316 medicamentos; 72,97% das entrevistadas, analgésicos (14,6%; 44% das gestantes e agentes anti-infecciosos de uso sistêmico (10,1%; 19,2% das gestantes, e os medicamentos foram: ácido fólico (17,72% IC(95% 13,67 - 22,39, sulfato ferroso (15,82% IC(95% 11,98 - 20,32 e paracetamol (12,97% IC(95% 9,47 - 17,19. 22% das 104 entrevistadas relataram o hábito de tabagismo antes da gestação e, 12,5% continuaram com o hábito durante o período gestacional, enquanto que 21 gestantes faziam uso de bebidas alcoólicas antes da gestação e, entre estas, 17 interromperam o consumo durante a gestação. Portanto, é reportado nesse estudo um grande número de medicamentos prescritos para gestantes, constante nas 5 classes de risco do FDA, incluindo uma grande quantidade de medicamentos das classes de alto risco teratogênico (D e X, e uma considerável proporção de gestantes utilizando

  5. Function of Receptor 1 in uptaking transferrin and its relation to iron deficiency and iron gestational preeclampsia

    OpenAIRE

    Gómez-Gutiérrez, Alejandra María; Parra-Sosa, Beatriz Elena; César Bueno-Sánchez, Julio

    2013-01-01

    La anemia ferropénica gestacional afecta al 48 % de las mujeres y se asocia con efectos deletéreos para la madre y el feto. Para la captación del hierro de la gestante es necesaria la expresión en el sincitiotrofoblasto de la glicoproteína receptor 1 de transferrina (TfR1). En ensayos celulares, en modelos animales y en humanos la deprivación de hierro se ha asociado a un aumento en la transcripción y expresión del TfR1, que se ha explicado como un mecanismo compensatorio para la captación de...

  6. Anemia y depleción de las reservas de hierro en adolescentes gestantes de una zona urbana y rural del estado Zulia, Venezuela

    OpenAIRE

    Ortega F, Pablo Antonio; Leal M, Jorymar Yoselyn; Chávez, Carlos Javier; Mejías C, Lidia; Chirinos Q, Noraima; Escalona V, Carolina del Pilar

    2012-01-01

    Objetivo: Analizar la prevalencia de anemia y depleción de las reservas corporales de hierro (DRFe) en adolescentes gestantes urbanas (U) y rurales (R). Metodología: Fueron estudiadas 214 adolescentes gestantes (U=100 y R=114), de baja condición socio-económica. Se realizó una evaluación clínica-obstétrica, nutricional y bioquímica. Según recomendaciones de la OMS y el Grupo Consultivo Internacional de Anemia se consideró anemia en gestantes, I y III trimestre Hb≤110g/L, y II trimestre Hb≤105...

  7. La inequidad en el acceso a la atención odontológica de las mujeres gestantes en Santander

    OpenAIRE

    Sonia Constanza Concha Sánchez; Carolina Morales Borrero

    2014-01-01

    Introducción: Las condiciones de vida, salud, atención y cuidado de las gestantes están comprometidas, en especial en las mujeres más pobres y vulnerables, y el componente bucal ejerce un papel importante en esta inequidad. Objetivo: Describir las condiciones sociales y económicas que determinan la inequidad en el acceso a la atención odontológica de las mujeres gestantes en Santander. Metodología: Se realizó un estudio observacional analítico de corte transversal que incluyó 8695 gestantes e...

  8. Historical evolution of ideas on eclampsia/preeclampsia: A proposed optimistic view of preeclampsia.

    Science.gov (United States)

    Robillard, Pierre-Yves; Dekker, Gustaaf; Chaouat, Gérard; Scioscia, Marco; Iacobelli, Silvia; Hulsey, Thomas C

    2017-09-01

    Eclampsia (together with epilepsy) being the first disease ever written down since the beginning of writings in mankind 5000 years ago, we will make a brief presentation of the different major steps in comprehension of Pre-eclampsia. 1) 1840. Rayer, description of proteinuria in eclampsia, 2) 1897 Vaquez, discovery of gestational hypertension in eclamptic women, 3) In the 1970's, description of the "double" trophoblastic invasion existing only in humans (Brosens & Pijnenborg,), 4) between the 1970's and the 1990's, description of preeclampsia being a couple disease. The "paternity problem" (and therefore irruption of immunology), 5) at the end of the 1980's, a major step forward: Preeclampsia being a global endothelial cell disease (glomeruloendotheliosis, hepatic or cerebral endotheliosis, HELLP, eclampsia), inflammation (J.Roberts.C Redman, R Taylor), 6) End of the 1990's: Consensus for a distinction between early onset preeclampsia EOP and late onset LOP (34 weeks gestation), EOP being rather a problem of implantation of the trophoblast (and the placenta), LOP being rather a pre-existing maternal problem (obesity, diabetes, coagulopathies etc…). LOP is predominant everywhere on this planet, but enormously predominant in developed countries: 90% of cases. This feature is very different in countries where women have their first child very young (88% of world births), where the fatal EOP (early onset) occurs in more than 30% of cases. 7) What could be the common factor which could explain the maternal global endotheliosis in EOP and LOP? Discussion about the inositol phospho glycans P type. Copyright © 2017. Published by Elsevier B.V.

  9. Women's Experiences of Preeclampsia: Australian Action on Preeclampsia Survey of Women and Their Confidants

    Science.gov (United States)

    East, C.; Conway, K.; Pollock, W.; Frawley, N.; Brennecke, S.

    2011-01-01

    Introduction. The experience of normal pregnancy is often disrupted for women with preeclampsia (PE). Materials and Methods. Postal survey of the 112 members of the consumer group, Australian Action on Pre-Eclampsia (AAPEC). Results. Surveys were returned by 68 women (61% response rate) and from 64 (57%) partners, close relatives or friends. Respondents reported experiencing pre-eclampsia (n = 53), eclampsia (n = 5), and/or Hemolysis, Elevated Liver enzymes, and Low Platelets (HELLP syndrome) (n = 26). Many women had no knowledge of PE prior to diagnosis (77%) and, once diagnosed, did not appreciate how serious or life threatening it was (50%). Women wanted access to information about PE. Their experience contributed substantial anxiety towards future pregnancies. Partners/friends/relatives expressed fear for the woman and/or her baby and had no prior understanding of PE. Conclusions. The PE experience had a substantial effect on women, their confidants, and their babies and affected their approach to future pregnancies. Access to information about PE was viewed as very important. PMID:21547089

  10. Relatos clínicos de contaminación y peligro. Cocreando desde dentro el estigma social en la gestante seropositiva

    Directory of Open Access Journals (Sweden)

    José Manuel Hernández Garre

    2015-12-01

    Full Text Available El objetivo del artículo ha sido explorar las principales representaciones de los sanitarios respecto a las parturientas VIH positivo, y sus posibles repercusiones en el proceso de creación/destrucción de su identidad en clave de estigma social. La metodología elegida ha sido la realización de una serie de entrevistas semiestructuradas, cuyos resultados muestran ciertos miedos e inseguridades que afloran en los sanitarios como consecuencia de la sensación de vulnerabilidad, miedos que se acrecientan en el parto, donde la posibilidad de infección se magnifica al tener contacto con fluidos corporales potencialmente contaminantes. La conclusión final es que la corporalidad de la gestante seropositiva se construye en los medios clínicos en clave negativa, apareciendo en los relatos dos tipos de estigma, el «determinante», asociado al peligro de contagio en sí mismo, y el «simbólico», derivado de las conductas socialmente desacreditadas que se relacionan popularmente a la enfermedad.

  11. Baixa autoestima situacional em gestantes: uma análise de acurácia Baja autoestima situacional en gestantes: un análisis de acurácia Situational low self-esteem in pregnant women: an analysis of accuracy

    Directory of Open Access Journals (Sweden)

    Joyce Carolle Bezerra Cavalcante

    2012-12-01

    Full Text Available Para investigar a acurácia de características definidoras do diagnóstico Baixa autoestima situacional, realizou-se um estudo transversal, com 52 gestantes atendidas num centro de atendimento familiar. Utilizou-se a taxonomia da NANDA-I e a escala de Rosenberg. O diagnóstico esteve presente em 32,7% das gestantes e todas as características apresentaram associação estatística com o diagnóstico, exceto "Relata verbalmente desafio situacional ao seu próprio valor". As características com maior sensibilidade foram "Comportamento indeciso" e "Expressões de desamparo" (82,35%. Já as características "Expressões de sentimento de inutilidade" e "Relata verbalmente desafio situacional atual ao seu próprio valor" apresentaram maior especificidade (94,29%. Tais resultados podem contribuir com a prática de enfermagem, pois a identificação de características acuradas é fundamental para uma inferência segura.Para investigar la acurácia de características definidoras del diagnostico Baja autoestima situacional, desarrollamos un estudio transversal, con 52 gestantes atendidas en un centro familiar. La taxonomía NANDA-I y la escala de Rosenberg fueron utilizadas. El diagnostico estaba presente en 32.7% de las mujeres y todas las características fueron estadísticamente significativas, a menos que "Informa verbalmente desafío situacional a su valor propio". Las características "Comportamiento incierto" y "Expresiones de abandono" tuvieron 82.35% de sensibilidad. Las características "Expresiones de sentimientos de inutilidad" y "Informa verbalmente desafío situacional a su valor propio" fueron las más específicas, con 94.29% de especificidad. Estos resultados pueden contribuir con la práctica de enfermería porque la identificación de características acuradas es esencial para una inferencia diagnostica segura.To investigate the accuracy of defining characteristics of Situational low self-esteem we developed a cross-sectional study

  12. New Insights into the Role of Matrix Metalloproteinases in Preeclampsia.

    Science.gov (United States)

    Espino Y Sosa, Salvador; Flores-Pliego, Arturo; Espejel-Nuñez, Aurora; Medina-Bastidas, Diana; Vadillo-Ortega, Felipe; Zaga-Clavellina, Veronica; Estrada-Gutierrez, Guadalupe

    2017-07-20

    Preeclampsia is a severe pregnancy complication globally, characterized by poor placentation triggering vascular dysfunction. Matrix metalloproteinases (MMPs) exhibit proteolytic activity implicated in the efficiency of trophoblast invasion to the uterine wall, and a dysregulation of these enzymes has been linked to preeclampsia. A decrease in MMP-2 and MMP-9 interferes with the normal remodeling of spiral arteries at early pregnancy stages, leading to the initial pathophysiological changes observed in preeclampsia. Later in pregnancy, an elevation in MMP-2 and MMP-9 induces abnormal release of vasoactive factors conditioning hypertension. Although these two enzymes lead the scene, other MMPs like MMP-1 and MMP-14 seem to have a role in this pathology. This review gathers published recent evidence about the implications of different MMPs in preeclampsia, and the potential use of these enzymes as emergent biomarkers and biological therapeutic targets, focusing on studies involving human subjects.

  13. Metabolic syndrome as a risk factor for hypertension after preeclampsia

    NARCIS (Netherlands)

    Spaan, J.J.; Sep, S.J.; van Balen, V.L.; Spaanderman, M.E.A.; Peeters, L.L.

    2012-01-01

    OBJECTIVE: To identify metabolic and obstetric risk factors associated with hypertension after preeclampsia. METHODS: We analyzed demographic and clinical data from a postpartum screening (blood pressure, microalbuminuria and fasting plasma levels of glucose, insulin, and lipid profile) from 683

  14. Bilateral Bell palsy as a presenting sign of preeclampsia.

    Science.gov (United States)

    Vogell, Alison; Boelig, Rupsa C; Skora, Joanna; Baxter, Jason K

    2014-08-01

    Bell palsy is a facial nerve neuropathy that is a rare disorder but occurs at higher frequency in pregnancy. Almost 30% of cases are associated with preeclampsia or gestational hypertension. Bilateral Bell palsy occurs in only 0.3%-2.0% of cases of facial paralysis, has a poorer prognosis for recovery, and may be associated with a systemic disorder. We describe a case of a 24-year-old primigravid woman with a twin gestation at 35 weeks diagnosed initially with bilateral facial palsy and subsequently with preeclampsia. She then developed partial hemolysis, elevated liver enzymes, and low platelet count syndrome, prompting the diagnosis of severe preeclampsia, and was delivered. Bilateral facial palsy is a rare entity in pregnancy that may be the first sign of preeclampsia and suggests increased severity of disease, warranting close monitoring.

  15. Relationship between Serum Zinc Levels and Preeclampsia at the ...

    African Journals Online (AJOL)

    46987.2

    Preeclampsia at the University Teaching Hospital,. Lusaka, Zambia. 139. 1. 2. 1. 3. L Chababa, M Mukosha, G Sijumbila, B Vwalika. 1 ... associated with increased oxidative stress. ... plasma zinc concentrations compared to pregnant women.

  16. Association of pre-eclampsia with metabolic syndrome and ...

    African Journals Online (AJOL)

    2015-11-25

    Nov 25, 2015 ... Preeclampsia has been linked to increased risk of developing heart disease later in life. The best approach for ... neonatal morbidity and mortality affecting 5–8% of all ... obesity, insulin resistance, and dyslipidemia[17] most of.

  17. Relationship of Reported Clinical Features of Pre-eclampsia and ...

    African Journals Online (AJOL)

    eclampsia assessed included headache, visual disturbance, urination, breathing, leg ... Conclusion: The high number of symptoms associated with preeclampsia among women with no formal education strongly supports the need for educational ...

  18. Micro RNA: New aspect in pathobiology of preeclampsia?

    African Journals Online (AJOL)

    Harapan Harapan

    2012-02-14

    Feb 14, 2012 ... esis theory; diagnosis and treatment approach to some diseases. ..... The first research that linked miRNA and PE was conducted by Pineles et al. .... mental retardation. Nat Cell .... innate immune system, and preeclampsia?

  19. New Insights into the Role of Matrix Metalloproteinases in Preeclampsia

    Directory of Open Access Journals (Sweden)

    Salvador Espino Y. Sosa

    2017-07-01

    Full Text Available Preeclampsia is a severe pregnancy complication globally, characterized by poor placentation triggering vascular dysfunction. Matrix metalloproteinases (MMPs exhibit proteolytic activity implicated in the efficiency of trophoblast invasion to the uterine wall, and a dysregulation of these enzymes has been linked to preeclampsia. A decrease in MMP-2 and MMP-9 interferes with the normal remodeling of spiral arteries at early pregnancy stages, leading to the initial pathophysiological changes observed in preeclampsia. Later in pregnancy, an elevation in MMP-2 and MMP-9 induces abnormal release of vasoactive factors conditioning hypertension. Although these two enzymes lead the scene, other MMPs like MMP-1 and MMP-14 seem to have a role in this pathology. This review gathers published recent evidence about the implications of different MMPs in preeclampsia, and the potential use of these enzymes as emergent biomarkers and biological therapeutic targets, focusing on studies involving human subjects.

  20. Gene expression profiling of placentas affected by pre-eclampsia

    DEFF Research Database (Denmark)

    Hoegh, Anne Mette; Borup, Rehannah; Nielsen, Finn Cilius

    2010-01-01

    Several studies point to the placenta as the primary cause of pre-eclampsia. Our objective was to identify placental genes that may contribute to the development of pre-eclampsia. RNA was purified from tissue biopsies from eleven pre-eclamptic placentas and eighteen normal controls. Messenger RNA...... expression from pooled samples was analysed by microarrays. Verification of the expression of selected genes was performed using real-time PCR. A surprisingly low number of genes (21 out of 15,000) were identified as differentially expressed. Among these were genes not previously associated with pre-eclampsia...... as bradykinin B1 receptor and a 14-3-3 protein, but also genes that have already been connected with pre-eclampsia, for example, inhibin beta A subunit and leptin. A low number of genes were repeatedly identified as differentially expressed, because they may represent the endpoint of a cascade of events...

  1. Criteria Based Audit of the Management of Severe Preeclampsia ...

    African Journals Online (AJOL)

    ... of the Management of Severe Preeclampsia/ Eclampsia in a Nigerian Teaching ... Awolowo University Teaching Hospitals Complex (OAUTHC), Ile-Ife, Nigeria. ... pre-determined standard of care based on 18 criteria, the performance score ...

  2. The Relevance of the Renin-Angiotensin System in the Development of Drugs to Combat Preeclampsia

    Directory of Open Access Journals (Sweden)

    Norikazu Ueki

    2015-01-01

    Full Text Available Preeclampsia is a hypertensive disorder that occurs during pregnancy. It has an unknown etiology and affects approximately 5–8% of pregnancies worldwide. The pathophysiology of preeclampsia is not yet known, and preeclampsia has been called “a disease of theories.” The central symptom of preeclampsia is hypertension. However, the etiology of the hypertension is unknown. In this review, we analyze the molecular mechanisms of preeclampsia with a particular focus on the pathogenesis of the hypertension in preeclampsia and its association with the renin-angiotensin system. In addition, we propose potential alternative strategies to target the renin-angiotensin system, which is enhanced during pregnancy.

  3. Metabolomic biomarkers in serum and urine in women with preeclampsia

    OpenAIRE

    Austdal, Marie; Skråstad, Ragnhild; Gundersen, Astrid; Austgulen, Rigmor; Iversen, Ann-Charlotte; Bathen, Tone Frost

    2014-01-01

    Objective To explore the potential of magnetic resonance (MR) metabolomics for study of preeclampsia, for improved phenotyping and elucidating potential clues to etiology and pathogenesis. Methods Urine and serum samples from pregnant women with preeclampsia (n = 10), normal pregnancies (n = 10) and non-pregnant women (n = 10) matched by age and gestational age were analyzed with MR spectroscopy and subjected to multivariate analysis. Metabolites were then quantified and compared ...

  4. Review: hCG, Preeclampsia and Regulatory T cells

    OpenAIRE

    Norris, Wendy; Nevers, Tania; Sharma, Surendra; Kalkunte, Satyan

    2011-01-01

    Human chorionic gonadotropin (hCG) is crucial for successful pregnancy. Its many functions include angiogenesis and immune regulation. Despite years of research, the etiology of preeclampsia remains unknown. Marked by insufficient trophoblast invasion and poor spiral artery remodeling, preeclampsia has also been linked to immune dysregulation. Here we discuss the roles of hCG in the context of endovascular cross-talk between trophoblasts and endothelial cells and immune tolerance. We propose ...

  5. Loss of Thrombomodulin in Placental Dysfunction in Preeclampsia.

    Science.gov (United States)

    Turner, Rosanne J; Bloemenkamp, Kitty W M; Bruijn, Jan A; Baelde, Hans J

    2016-04-01

    Preeclampsia is a pregnancy-specific syndrome characterized by placental dysfunction and an angiogenic imbalance. Systemically, levels of thrombomodulin, an endothelium- and syncytiotrophoblast-bound protein that regulates coagulation, inflammation, apoptosis, and tissue remodeling, are increased. We aimed to investigate placental thrombomodulin dysregulation and consequent downstream effects in the pathogenesis of preeclampsia. Placentas from 28 preeclampsia pregnancies, 30 uncomplicated pregnancies, and 21 pregnancies complicated by growth restriction as extra controls were included. Immunohistochemical staining of thrombomodulin, caspase-3, and fibrin was performed. Placental mRNA expression of thrombomodulin, inflammatory markers, matrix metalloproteinases 2 and 9, and soluble Flt-1 were measured with quantitative polymerase chain reaction. Thrombomodulin mRNA expression was determined in vascular endothelial growth factor-transfected trophoblast cell lines. Thrombomodulin protein and mRNA expression were decreased in preeclampsia as compared with both control groups (P=0.001). Thrombomodulin mRNA expression correlated with maternal body mass index (Ppreeclampsia. An increase in placental apoptotic cells was associated with preeclampsia (Ppreeclampsia, but not with fibrin deposits or inflammatory markers. Placental soluble Flt-1 expression correlated with decreased thrombomodulin expression. Vascular endothelial growth factor induced upregulation of thrombomodulin expression in trophoblast cells. Decreased thrombomodulin expression in preeclampsia may play a role in placental dysfunction in preeclampsia and is possibly caused by an angiogenic imbalance. Hypertension and obesity are associated with thrombomodulin downregulation. These results set the stage for further basic and clinical research on thrombomodulin in the pathogenesis of preeclampsia and other syndromes characterized by endothelial dysfunction. © 2016 American Heart Association, Inc.

  6. Maternal serum ratio of ghrelin to obestatin decreased in preeclampsia.

    Science.gov (United States)

    Wu, Weiguang; Fan, Xiaobin; Yu, Yuecheng; Wang, Yingchun

    2015-10-01

    Ghrelin, an endogenous for the growth hormone secretagogue receptor, has been shown to participate in blood pressure regulation. Obestatin, encoded by the same gene as ghrelin, is described as a physiological opponent of ghrelin. We hypothesized that ghrelin/obestatin imbalance played a role in the pathogenesis. This study was designed to determine the alterations of ghrelin and obestatin concentrations and ghrelin/obestatin ratio in maternal serum in preeclampsia. This retrospective case-control study included 31 preeclampsia and 31 gestational week-matched normal pregnancies. Ghrelin and obestatin concentrations in maternal serum were determined by radioimmunoassay, and the ghrelin/obestatin ratio was calculated. The ghrelin concentration and ghrelin/obestatin ratio in maternal serum were significantly lower in preeclampsia than in normal pregnancies (214.34±14.27pg/mL vs 251.49±16.15pg/mL, P=0.041, 1.07±0.09 vs 0.82±0.08, P=0.023). The obestatin concentration in maternal serum was significantly higher in preeclampsia than in normal pregnancies (276.35±15.38pg/mL vs 223.53±18.61pg/mL, P=0.019). The systolic blood pressure in preeclampsia was negatively correlated with ghrelin concentration and ghrelin/obestatin ratio (r=-0.549, P=0.003; r=-0.491, P=0.004) and was positively correlated with obestatin concentrations in preeclampsia (r=0.388, P=0.013). The findings of this study suggested disturbance of ghrelin and obestatin in maternal serum in preeclampsia, and ghrelin/obestatin imbalance might play a role in the pathogenesis of preeclampsia. Copyright © 2015 International Society for the Study of Hypertension in Pregnancy. Published by Elsevier B.V. All rights reserved.

  7. Contemporary Clinical Management of the Cerebral Complications of Preeclampsia

    Directory of Open Access Journals (Sweden)

    Stefan C. Kane

    2013-01-01

    Full Text Available The neurological complications of preeclampsia and eclampsia are responsible for a major proportion of the morbidity and mortality arising from these conditions, for women and their infants alike. This paper outlines the evidence base for contemporary management principles pertaining to the neurological sequelae of preeclampsia, primarily from the maternal perspective, but with consideration of fetal and neonatal aspects as well. It concludes with a discussion regarding future directions in the management of this potentially lethal condition.

  8. Contemporary Clinical Management of the Cerebral Complications of Preeclampsia

    OpenAIRE

    Kane, Stefan C.; Dennis, Alicia; da Silva Costa, Fabricio; Kornman, Louise; Brennecke, Shaun

    2013-01-01

    The neurological complications of preeclampsia and eclampsia are responsible for a major proportion of the morbidity and mortality arising from these conditions, for women and their infants alike. This paper outlines the evidence base for contemporary management principles pertaining to the neurological sequelae of preeclampsia, primarily from the maternal perspective, but with consideration of fetal and neonatal aspects as well. It concludes with a discussion regarding future directions in t...

  9. O uso de anti-retrovirais em gestantes modifica o perfil lipídico?

    Directory of Open Access Journals (Sweden)

    El Beitune Patrícia

    2003-01-01

    Full Text Available OBJETIVO: avaliar o efeito das medicações anti-retrovirais sobre o metabolismo lipídico em gestantes portadoras do HIV. MÉTODOS: estudo prospectivo realizado em 57 gestantes que foram divididas em três grupos: grupo AZT, com 20 pacientes portadoras do HIV em uso de AZT; grupo TT, com 25 pacientes portadoras do HIV em uso de esquemas contendo três anti-retrovirais (AZT + 3TC + NFV e grupo controle, com 12 pacientes. Os dados demográficos e antropométricos foram homogêneos entre os grupos estudados. Foram excluídas as pacientes com antecedentes pessoais ou familiares de hiperlipidemia. Amostras sanguíneas foram obtidas para avaliação dos lipídeos (colesterol total, frações LDL e HDL-colesterol e triglicerídeos em quatro oportunidades durante a gravidez (1º = 14-20 semanas; 2º = 21-26 semanas; 3º = 27-32 semanas e 4º = 33-38 semanas. Os dados foram analisados utilizando-se os testes não paramétricos do chi², teste de Friedman e teste de Kruskal-Wallis. RESULTADOS: o uso de anti-retrovirais durante a gestação não induziu diferenças nas taxas do colesterol total e HDL, no entanto, o uso destes agentes esteve associado a elevação de 76,5 mg/dL e 84 mg/dL para 96 mg/dL e 105 mg/dL na concentração da fração LDL-colesterol para os grupos AZT e TT, respectivamente (p<0,01. Observou-se associação positiva significante entre os triglicerídeos e a carga viral nas gestantes do grupo AZT (r = 0,53; p = 0,015. CONCLUSÃO: a utilização dos anti-retrovirais durante a gestação eleva significativamente a concentração da lipoproteína LDL. Persistem as dúvidas se a gestação potencializa a longo prazo os efeitos dos anti-retrovirais sobre o metabolismo lipídico.

  10. Therapeutically targeting mitochondrial redox signalling alleviates endothelial dysfunction in preeclampsia.

    Science.gov (United States)

    McCarthy, Cathal; Kenny, Louise C

    2016-09-08

    Aberrant placentation generating placental oxidative stress is proposed to play a critical role in the pathophysiology of preeclampsia. Unfortunately, therapeutic trials of antioxidants have been uniformly disappointing. There is provisional evidence implicating mitochondrial dysfunction as a source of oxidative stress in preeclampsia. Here we provide evidence that mitochondrial reactive oxygen species mediates endothelial dysfunction and establish that directly targeting mitochondrial scavenging may provide a protective role. Human umbilical vein endothelial cells exposed to 3% plasma from women with pregnancies complicated by preeclampsia resulted in a significant decrease in mitochondrial function with a subsequent significant increase in mitochondrial superoxide generation compared to cells exposed to plasma from women with uncomplicated pregnancies. Real-time PCR analysis showed increased expression of inflammatory markers TNF-α, TLR-9 and ICAM-1 respectively in endothelial cells treated with preeclampsia plasma. MitoTempo is a mitochondrial-targeted antioxidant, pre-treatment of cells with MitoTempo protected against hydrogen peroxide-induced cell death. Furthermore MitoTempo significantly reduced mitochondrial superoxide production in cells exposed to preeclampsia plasma by normalising mitochondrial metabolism. MitoTempo significantly altered the inflammatory profile of plasma treated cells. These novel data support a functional role for mitochondrial redox signaling in modulating the pathogenesis of preeclampsia and identifies mitochondrial-targeted antioxidants as potential therapeutic candidates.

  11. Frequency and Factors Leading to Recurrent Pre-Eclampsia

    International Nuclear Information System (INIS)

    Emanuel, M.; Butt, S.

    2015-01-01

    Objective: To determine the frequency and factors leading to recurrent preeclampsia. Methods: The cross-sectional study was conducted at the Jinnah Post Graduate Medical Centre, Karachi, from January 2011 to February 2012, and comprised parous subjects <40 years of age with history of preeclampsia in previous pregnancy/pregnancies with singleton pregnancy and gestational age of >20 weeks. Gestational age was determined by early scan with preeclampsia in index pregnancy. Data was collected through a specialised questionnaire and analysed using SPSS 16. Results: Of the 479 patients seen with preeclampsia, 121(25.26 percent) were of recurrent preeclampsia. The mean age of such patients was 29.7±4.9 years (range: 20-39 years). Further, 84(69.42 percent) patients were multipara and 40(33.05 percent) were grand multipara. Mean body mass index was 29.97±6.2 (range: 18-54). Besides, 28(23.14 percent) patients had gestational diabetes; 7(5.78 percent) were known diabetics; 24(19.83 percent) had chronic hypertension; 2(1.7 percent) patients had chronic renal disease; and 1(0.8 percent) had connective tissue disorder. Conclusion: Being over-weight, having gestational diabetes and chronic hypertension were main risk factors leading to recurrent preeclampsia. (author)

  12. Periodontal disease and pre-eclampsia: a systematic review.

    Science.gov (United States)

    Kunnen, Alina; van Doormaal, Jasper J; Abbas, Frank; Aarnoudse, Jan G; van Pampus, Maria G; Faas, Marijke M

    2010-12-01

    This review evaluates the possible relationship between periodontal disease and pre-eclampsia, a major pregnancy complication. A generalized inflammatory response plays an important role in the pathogenesis of pre-eclampsia. Because periodontal disease is a low-grade inflammatory state, periodontal disease might contribute to the pathogenesis of pre-eclampsia. A literature search of PubMed, EMBASE and CINAHL until August 2010 revealed 12 eligible observational studies and three randomized-controlled trials (RCTs). It appeared difficult to compare these studies, due to variations in definitions of periodontal disease and pre-eclampsia, timing of periodontal examination and inadequate control for confounding factors. Eight observational studies reported a positive association, while four studies found no association. None of the RTCs reported reductions in pre-eclamptic rate after periodontal therapy during pregnancy. Therefore, it is questionable whether periodontal disease plays a causal role in the pathogenesis of pre-eclampsia. The observed association in eight observational studies might be the result of induction of periodontal disease due to the pre-eclamptic state or it may be an epiphenomenon of an exaggerated inflammatory response to pregnancy. Larger RCTs with pre-eclampsia as the primary outcome and pathophysiological studies are required to explore causality and to dissect biological mechanisms involved. © 2010 John Wiley & Sons A/S.

  13. Late onset postpartum preeclampsia 3 months after delivery.

    Science.gov (United States)

    Giwa, Al; Nguyen, Melissa

    2017-10-01

    Preeclampsia is defined by the American College of Obstetrics and Gynecology (ACOG) as "the occurrence of new onset hypertension plus new-onset proteinuria" [1]. Up-to-Date elaborates a little further on this by defining preeclampsia as "the new onset of hypertension and proteinuria, or hypertension and end-organ dysfunction with or without proteinuria, after 20 weeks of gestation in a previously normotensive woman. It may also develop postpartum. Severe hypertension or signs/symptoms of end-organ injury represent the severe end of the disease spectrum" [2] In 2013, the American College of Obstetricians and Gynecologists removed proteinuria as a key component in the diagnosis of preeclampsia. They also removed massive proteinuria (previously, 5 g/24 hours) and fetal growth restriction as possible features of severe disease. They found that were was a poor correlation in many outcomes between massive proteinuria and fetal growth restriction when managed similarly, with or without preeclampsia as a diagnosis. Oliguria was also removed as a characteristic of severe disease. [3] There have been several cases reported in the literature as well as by Obstetricians citing the incidence of preeclampsia occurring upwards of 6 to even 12 weeks postpartum. We hope to demonstrate what we believe to be a case of postpartum preeclampsia at 89 days postpartum. Published by Elsevier Inc.

  14. Maternal and Paternal Height and the Risk of Preeclampsia.

    Science.gov (United States)

    Lee, Yunsung; Magnus, Per

    2018-04-01

    The etiology of preeclampsia is unknown. Tall women have been found to have lower incidence of preeclampsia. This points to a possible biological causal effect but may be because of socioeconomic confounding. We used paternal height as an unexposed control to examine confounding. The MoBa (Norwegian Mother and Child Cohort Study) was used to extract data on parental heights, maternal prepregnancy weight, other background factors, and pregnancy outcomes for 99 968 singleton births. Multiple logistic regression was used to estimate odds ratios for preeclampsia according to parental height. The adjusted odds ratio for preeclampsia was 0.74 (95% CI, 0.66-0.82) for women >172 cm as compared with women 186 cm was 1.03 (95% CI, 0.93-1.15) compared with men <178 cm. The association between maternal height and preeclampsia is unlikely to be because of confounding by familial, socioeconomic factors or by fetal genes related to height. The observed association between maternal height and preeclampsia merits further investigation. © 2018 American Heart Association, Inc.

  15. Galectin signature in normal pregnancy and preeclampsia.

    Science.gov (United States)

    Blois, Sandra M; Barrientos, Gabriela

    2014-03-01

    Members of the galectin family are expressed within the female reproductive tract and have been shown to be involved in multiple biological functions that support the progression of pregnancy. Specific expression patterns of different members of this family have been identified at the maternal decidua and on the placental side. In some cases, mechanisms by which galectins exert their functions have been delineated in adverse pregnancy outcomes. This review summarizes studies on galectins that have been documented to be important for pregnancy maintenance, either supporting the maternal adaptation to pregnancy or the placentation process. In addition, we focus our discussion on the role of galectins in preeclampsia, a specific life-threatening pregnancy disorder. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

  16. Effect of Periodontal Disease on Preeclampsia

    Science.gov (United States)

    Sayar, F; Hoseini, M Sadat; Abbaspour, S

    2011-01-01

    Background: A lot of studies have shown periodontal diseases as a risk factor for adverse pregnancy outcomes. The association between periodontitis and preeclampsia has been studied recently with controversy. Considering the importance of preventing preeclampsia as a dangerous and life-threatening disease in pregnant women, the present study was carried out. Methods: Two hundred and ten pregnant women participated in this case-control study (105 controls & 105 cases) during years 2007 and 2008. Preeclamptic cases were defined as blood pressure ≥140/90mmHg and proteinuria +1. Control group were pregnant women with normal blood pressure without proteinuria. Both groups were examined during 48 hours after child delivery. Plaque Index (PLI), Pocket Depth (PD), Clinical Attachment Level (CAL), Bleeding On Probing (BOP), Gingival Recession (GR) were measured on all teeth except for third molars and recorded as periodontal examination. Data was analyzed using t-test, chi-square, and Mann-Whitney U statistical tests. Results: There was no significant difference between the two study groups for PD. CAL, GR, BOP significantly increased in the case group (P< 0.02). This study showed that preeclamptic cases were more likely to develop periodontal disease (P< 0.0001). Eighty three percent of the control group and 95% of the case group had periodontal disease (P< 0.005) which had shown that preeclamptic cases were 4.1 times more likely to have periodontal disease (OR= 4.1). Conclusion: Preeclamptic cases significantly had higher attachment loss and gingival recession than the control group. PMID:23113094

  17. Matrix Metalloproteinases in Normal Pregnancy and Preeclampsia

    Science.gov (United States)

    Chen, Juanjuan; Khalil, Raouf A.

    2017-01-01

    Normal pregnancy is associated with marked hemodynamic and uterine changes that allow adequate uteroplacental blood flow and uterine expansion for the growing fetus. These pregnancy-associated changes involve significant uteroplacental and vascular remodeling. Matrix metalloproteinases (MMPs) are important regulators of vascular and uterine remodeling. Increases in MMP-2 and MMP-9 have been implicated in vasodilation, placentation and uterine expansion during normal pregnancy. The increases in MMPs could be induced by the increased production of estrogen and progesterone during pregnancy. MMP expression/activity may be altered during complications of pregnancy. Decreased vascular MMP-2 and MMP-9 may lead to decreased vasodilation, increased vasoconstriction, hypertensive pregnancy and preeclampsia. Abnormal expression of uteroplacental integrins, cytokines and MMPs may lead to decreased maternal tolerance, apoptosis of invasive trophoblast cells, inadequate remodeling of spiral arteries, and reduced uterine perfusion pressure (RUPP). RUPP may cause imbalance between the anti-angiogenic factors soluble fms-like tyrosine kinase-1 and soluble endoglin and the pro-angiogenic vascular endothelial growth factor and placental growth factor, or stimulate the release of inflammatory cytokines, hypoxia-inducible factor, reactive oxygen species, and angiotensin AT1 receptor agonistic autoantibodies. These circulating factors could target MMPs in the extracellular matrix as well as endothelial and vascular smooth muscle cells, causing generalized vascular dysfunction, increased vasoconstriction and hypertension in pregnancy. MMP activity can also be altered by endogenous tissue inhibitors of metalloproteinases (TIMPs) and changes in the MMP/TIMP ratio. In addition to their vascular effects, decreases in expression/activity of MMP-2 and MMP-9 in the uterus could impede uterine growth and expansion and lead to premature labor. Understanding the role of MMPs in uteroplacental and

  18. Malária grave em gestantes Severe malaria in pregnant women

    Directory of Open Access Journals (Sweden)

    Flavia Barbosa Fernandes

    2010-12-01

    Full Text Available OBJETIVO: analisar a evolução clínica de três pacientes grávidas com malária grave internadas em unidade de terapia intensiva de um hospital localizado em Porto Velho (RO. MÉTODOS: foi realizado estudo descritivo em três gestantes, portadoras de malária por Plasmodium falciparum, internadas em unidade de terapia intensiva em Porto Velho, no período de 2005 a 2006. As variáveis categóricas utilizadas foram os critérios de classificação da Organização Mundial de Saúde para classificação de malária grave e os índices Acute Physiology and Chronic Health disease Classification System II (APACHE II e Sepsis Related Organ Failure Assessment (SOFA preditores de morbidade e gravidade das doenças em unidade de terapia intensiva. RESULTADOS: a malária adquirida pelas gestantes, caracterizada pela infecção por Plasmodium falciparum na forma grave da doença, resultou em óbito para as três pacientes e seus conceptos. CONCLUSÕES: embora a casuística seja pequena, a importância deste estudo reflete a repercussão da malária grave em gestantes, bem como a necessidade de um acompanhamento pré-natal mais criterioso e atento à identificação precoce do início das complicações da malária em gestantes.PURPOSE: to analyze the clinical course of three pregnant patients with severe malaria admitted to the intensive care unit of a hospital in Porto Velho (RO, Brazil. METHODS: a descriptive study was conducted on three pregnant women infected with Plasmodium falciparum malaria, admitted to the intensive care unit of a hospital in Porto Velho from 2005 to 2006. Categorical variables used were the classification criteria of the World Health Organization which ranks severe malaria and the Acute Physiology and Chronic Health Disease Classification System II (APACHE II and Sepsis Related Organ Failure Assessment (SOFA predictors of morbidity and severity of intensive care unit diseases. RESULTS: the malaria acquired by the pregnant

  19. Trauma na gestante: análise da mortalidade materna e fetal

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    Paulo Roberto Corsi

    Full Text Available Foram analisadas retrospectivamente 26 pacientes gestantes traumatizadas, num período de nove anos. A média de idade foi 23,7 anos (16-42. A idade gestacional variou de dez a quarenta semanas (média 21,5 semanas; a maioria (46,1% no segundo trimestre. O mecanismo predominante (65,3% foi o trauma abdominal fechado por acidente automobilístico (atropelamento ou colisão. Na admissão, oito (30,7% pacientes apresentavam alterações hemodinâmicas. Seis doentes (23,0% apresentavam sangramento vaginal e, destas, quatro estavam hemodinamicamente normais. Analisamos a mortalidade materna, a mortalidade fetal e suas causas. Comparamos também a mediana dos valores do RTS e TRISS entre os grupos, sobrevida materno-fetal, sobrevida materna e óbito materno-fetal. Todas as gestantes admitidas com sangramento vaginal apresentaram óbito fetal. A mortalidade materna foi de 11,5%, por choque hemorrágico. A mortalidade fetal foi de 30,7%, sendo que 37,5% destes óbitos foram provocados pela morte materna. A principal causa de mortalidade fetal foi o descolamento de placenta (50,0%. Os índices de trauma, RTS e TRISS, foram significativamente menor (p=0,0025 e p<0,0001 no grupo óbito materno-fetal, porém esses índices não apresentaram valor prognóstico na mortalidade fetal.

  20. Motivação de gestantes para o aleitamento materno Motivating breastfeeding among expectant mothers

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    Sueli Aparecida Moreira Takushi

    2008-10-01

    Full Text Available OBJETIVO: Conhecer os motivos de gestantes para o aleitamento materno. MÉTODOS: É um estudo qualitativo realizado com 164 gestantes assistidas no pré-natal em dois Centros de Saúde na região central da cidade de São Paulo. Os dados foram coletados por meio de entrevistas semi-estruturadas sobre motivação para amamentar. As narrativas foram organizadas em planilha eletrônica em busca de categorias. RESULTADOS: As principais categorias identificadas estavam relacionadas à saúde da criança, da mulher e aos benefícios da prática de amamentar e do leite materno. A maioria das mulheres (98,8% foi favorável à amamentação. Benefícios à saúde da criança foi o motivo mais freqüente (73,8%. CONCLUSÃO: A motivação ao aleitamento materno foi centrada nos benefícios à saúde da criança. A amamentação é valorizada independentemente da vontade materna.OBJECTIVE: The present study sought to discover the reasons for expectant mothers to breastfeed. METHODS: This was a qualitative study involving 164 expectant mothers attending prenatal care in two health centers of the city of São Paulo. Semi-structured interviews were done to collect data on the reasons to breastfeed. The information was organized in a spreadsheet to search for categories. RESULTS: The main identified categories regarded the child's and woman's health and the benefits of breastfeeding and breast milk. The majority of the women (98.8% regarded breastfeeding favorably. Benefit to the child's health was the reason mentioned most often (73.8%. CONCLUSION: Motivation to breastfeed was based on benefits to the child's health. Breastfeeding is valued regardless of the mother's will.

  1. Preeclampsia Associates with Asthma, Allergy, and Eczema in Childhood.

    Science.gov (United States)

    Stokholm, Jakob; Sevelsted, Astrid; Anderson, Ulrik D; Bisgaard, Hans

    2017-03-01

    Preeclampsia reflects an unusual increase in systemic inflammation during pregnancy. We studied associations between preeclampsia and asthma, allergy, and eczema in Copenhagen Prospective Studies on Asthma in Childhood 2000 (COPSAC 2000 ) and in national registries. COPSAC 2000 is a high-risk birth cohort of 411 Danish children. Asthma, allergy, and eczema were diagnosed prospectively, and lung function measured at age 1 month and 7 years. Sensitization was evaluated at age 6 months, 18 months, 4 years, and 6 years by skin prick tests and IgE measurements. The register-based cohort included 1.7 million children from Danish national registries in the 35-year period 1977-2012. Children born to mothers with preeclampsia were analyzed regarding risk of asthma, allergy, and eczema. In the COPSAC 2000 cohort, 5.6% (n = 23) were diagnosed with preeclampsia. Preeclampsia was associated with increased risk of treatment with inhaled corticosteroids at age 7 years (adjusted odds ratio, 4.01 [95% confidence interval (CI), 1.11-14.43]; P = 0.0337), increased bronchial responsiveness to methacholine (adjusted β-coefficient log-μmol, -0.80 [95% CI, -1.55 to -0.06]; P = 0.0348), and allergic rhinitis (adjusted odds ratio, 4.83 [95% CI, 1.58-14.78]; P = 0.0057) in the 7-year-old children. Furthermore, the children had an increased risk of sensitization to both aeroallergens and food allergens, and increased amount of total IgE during childhood. In the registry-based cohort, 3.7% (n = 62,728) were born to mothers with preeclampsia. Preeclampsia was associated with increased risk of asthma, eczema, and aeroallergen and food allergy, especially pronounced after a duration of preeclampsia of 14 days or more. Maternal asthma increased the risk of preeclampsia. Preeclampsia is a shared prenatal risk factor for asthma, eczema, and allergy in childhood pointing toward in utero immune programming of the child.

  2. Evidence-Based Revised View of the Pathophysiology of Preeclampsia.

    Science.gov (United States)

    Ahmed, Asif; Rezai, Homira; Broadway-Stringer, Sophie

    2017-01-01

    Preeclampsia is a life-threatening vascular disorder of pregnancy due to a failing stressed placenta. Millions of women risk death to give birth each year and globally each year, almost 300,000 lose their life in this process and over 500,000 babies die as a consequence of preeclampsia. Despite decades of research, we lack pharmacological agents to treat it. Maternal endothelial oxidative stress is a central phenomenon responsible for the preeclampsia phenotype of high maternal blood pressure and proteinuria. In 1997, it was proposed that preeclampsia arises due to the loss of VEGF activity, possibly due to elevation in anti-angiogenic factor, soluble Flt-1 (sFlt-1). Researchers showed that high sFlt-1 and soluble endoglin (sEng) elicit the severe preeclampsia phenotype in pregnant rodents. We demonstrated that heme oxygenase-1 (HO-1)/carbon monoxide (CO) pathway prevents placental stress and suppresses sFlt-1 and sEng release. Likewise, hydrogen sulphide (H 2 S)/cystathionine-γ-lyase (Cth) systems limit sFlt-1 and sEng and protect against the preeclampsia phenotype in mice. Importantly, H 2 S restores placental vasculature, and in doing so improves lagging fetal growth. These molecules act as the inhibitor systems in pregnancy and when they fail, preeclampsia is triggered. In this review, we discuss what are the hypotheses and models for the pathophysiology of preeclampsia on the basis of Bradford Hill causation criteria for disease causation and how further in vivo experimentation is needed to establish 'proof of principle'. Hypotheses that fail to meet the Bradford Hill causation criteria include abnormal spiral artery remodelling and inflammation and should be considered associated or consequential to the disorder. In contrast, the protection against cellular stress hypothesis that states that the protective pathways mitigate cellular stress by limiting elevation of anti-angiogenic factors or oxidative stress and the subsequent clinical signs of preeclampsia

  3. Registro periodontal simplificado em gestantes Periodontal screening and recording in pregnant women

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    Fernanda L. Rosell

    1999-04-01

    Full Text Available OBJETIVO: Avaliar através do PSR (Registro Periodontal Simplificado a prevalência, severidade e necessidades básicas de tratamento da doença periodontal em gestantes que freqüentaram a Clínica de Prevenção da Faculdade de Odontologia de Araraquara ­ UNESP. MÉTODOS: Foram examinadas 41 gestantes com idades que variaram de 16 a 37 anos. O PSR foi aplicado com auxílio de uma sonda especialmente recomendada para este exame (sonda Trinity - tipo 621 OMS, indicando os códigos 0 a 4 cujos critérios identificam de saúde gengival, sangramento, cálculo, bolsa periodontal rasa e profunda. Estes foram atribuídos a cada sextante, podendo ou não estarem associados a um asterisco (* diante da presença de recessão gengival, invasão de furca, mobilidade ou alterações muco-gengivais. RESULTADOS: Demonstraram que 100% das gestantes apresentaram alguma alteração gengival, sendo os códigos 2 (56,1% e o * (19,5% os mais prevalentes. Os grupos etários de 15-19 e 20-24 anos, apresentaram o código 2 como maior escore e ausência de sextante excluído (X. A partir do grupo de 25-29 anos, além da maior prevalência ainda ser do código 2 (54,5%, ocorreram os códigos 3 e 4 (bolsa periodontal. Os códigos * e sextante excluído (X tenderam a aumentar com a idade no grupo de 30-37 anos. De modo geral, os códigos 1 e 2, prevaleceram em relação ao percentual de sextantes afetados, correspondendo a 41,6% e 39,8%, respectivamente e afetando 2,49 e 2,39 sextantes, em média, por gestante. Em relação às necessidades de tratamento, 90,2% das gestantes necessitaram tratamentos adicionais aos preventivos, ou seja, 61,0% das gestantes necessitaram de raspagem e alisamento radicular e/ou eliminar margens de restaurações defeituosas e 29,2% de tratamento complexo. CONCLUSÃO: O atendimento às necessidades de tratamento na gravidez deve receber especial atenção com o intuito de se promover saúde bucal e motivação, e conseqüentemente, contribuir

  4. Alterações ultra-estruturais do glomérulo na pré-eclâmpsia Ultrastructural glomerular alterations in preeclampsia

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    Suzana Maria Pires do Rio

    2004-04-01

    Full Text Available OBJETIVOS: identificar as alterações ultra-estruturais glomerulares em pacientes com pré-eclâmpsia grave, assim como avaliar a evolução destas lesões e sua relação com o momento de realização da biópsia renal. MÉTODOS: dentre as 72 gestantes com síndrome hipertensiva que se submeteram à biópsia renal no puerpério, em 39 o material obtido mostrou-se adequado para exame à microscopia eletrônica de transmissão, assim distribuídas: 25 eram portadoras de pré-eclâmpsia pura e 14 tiveram diagnóstico de pré-eclâmpsia superposta à hipertensão arterial crônica. As apresentações morfológicas estiveram representadas por rim normal, edema das células endoteliais, expansão do mesângio, interposição mesangial, depósitos subendoteliais e fusão dos pés dos podócitos. RESULTADOS: as alterações mais freqüentes nos dois grupos foram os depósitos subendoteliais e a fusão dos pés dos podócitos. O edema da célula endotelial ocorreu em 84% das pacientes com pré-eclâmpsia pura e 92,9% das pacientes com pré-eclâmpsia superposta. Não foi observada associação entre a gravidade da doença e a intensidade do edema da célula endotelial. Verificou-se tendência de interposição mesangial em pacientes biopsiadas após o sétimo dia pós-parto. A fusão dos podócitos apresentou associação significativa com a proteinúria de 24 horas. CONCLUSÕES: as alterações glomerulares citadas representam espectro de lesões complexas e dinâmicas que, em conjunto, constituem as características ultra-estruturais da pré-eclâmpsia, que não deve, pois, ser identificada somente pela presença do edema da célula endotelial.PURPOSE: to investigate the glomerular alterations in patients with severe preeclampsia, as well as to evaluate the evolution of these lesions, relating them to the moment of the renal biopsy. METHODS: seventy-two pregnant women with hypertensive syndrome underwent renal biopsy in the puerperium. Appropriate

  5. Maternal serum copeptin concentrations in early- and late-onset pre-eclampsia

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    Abdullah Tuten

    2015-08-01

    Conclusion: Our results suggest that copeptin levels might be useful in the evaluation of the severity of pre-eclampsia. However, copeptin might be involved in early- rather than late-onset pre-eclampsia.

  6. A prospective study of trans fat intake and risk of preeclampsia in Denmark

    DEFF Research Database (Denmark)

    Chavarro, J. E.; Halldorsson, T. I.; Leth, Torben

    2011-01-01

    Association of intake of trans fatty acids in the 2nd trimester of pregnancy with risk of preeclampsia was studied by following 67 186 pregnancies of women participating in the Danish National Birth Cohort between 1998 and 2003. Diet was assessed with a food frequency questionnaire at gestation wk...... 25; preeclampsia diagnosis was obtained by linkage with the Danish National Patient Registry. 1804 cases of preeclampsia and 402 cases of severe preeclampsia were identified in the cohort. Intake of trans fats decreased during the study period as a consequence of reduction in industrial trans fat...... intake. Intake of trans fats in the 2nd trimester was unrelated to risk of preeclampsia or severe preeclampsia. Relative risk (95% confidence interval; P, trend) of preeclampsia and severe preeclampsia comparing top to bottom quintiles of trans fat intake were 0.95 (0.81; 1.11, 0.33) and 1.07 (0.78; 1...

  7. Preeclampsia is associated with ambulatory arterial stiffness index in type 1 diabetes mellitus

    DEFF Research Database (Denmark)

    Al-Far, Hanine FM; Tjessem, Ingvild H; Fuglsang, Jens

    2017-01-01

    , and monitoring effects. Aim: To determine the association between AASI in women with type 1 diabetes mellitus (T1DM) and preeclampsia, and to assess the ability of AASI to diagnose preeclampsi. To apply validated methods to diagnose preeclampsia and association with arterial ambulatory stiffness index (AASI...... ratio, night blood pressure divided by day blood pressure. Results: Of the T1DM women, 33 developed preeclampsia, which was associated with AASI in the 3rd trimester (p preeclampsia in T1DM was an AASI of 0.35. The diurnal blood pressure was significantly higher in all...... trimesters in women who later had preeclampsia. A flattened circadian rhythm was present in T1DM women with preeclampsia compared to women without preeclampsia (night-day ratio: systole 2nd trimester: 0.94 ± 0.07 vs. 0.91 ± 0.05, women with and without preeclampsia, respectively, p = 0.015; diastole 2nd...

  8. Circulating asymmetric dimethylarginine and the risk of preeclampsia: a meta-analysis based on 1338 participants.

    Science.gov (United States)

    Yuan, Jing; Wang, Xinguo; Xie, Yudou; Wang, Yuzhi; Dong, Lei; Li, Hong; Zhu, Tongyu

    2017-07-04

    Patients with preeclampsia have higher circulating asymmetric dimethylarginine (ADMA). However, whether circulating ADMA is elevated before the diagnosis of preeclampsia has not been determined. A meta-analysis of observational studies that reported circulating ADMA level before the onset of preeclampsia was performed. Pubmed and Embase were searched. Standardized mean differences (SMD) with 95% confidence intervals (CI) were used to estimate the differences in circulating ADMA. A random effect model or a fixed effect model was applied depending on the heterogeneity. The predictive efficacy of circulating ADMA for the incidence of preeclampsia was also explored. Eleven comparisons with 1338 pregnant women were included. The pooled results showed that the circulating ADMA was significantly higher in women who subsequently developed preeclampsia as compared with those did not (SMD: 0.71, p preeclampsia, and retrieved moderate predictive efficacy. Circulating ADMA is elevated before the development of preeclampsia. Studies are needed to evaluate the predictive efficacy of ADMA for the incidence of preeclampsia.

  9. Factors associated with severe preeclampsia and eclampsia in Jahun, Nigeria

    Directory of Open Access Journals (Sweden)

    Guerrier G

    2013-08-01

    Full Text Available Gilles Guerrier,1 Bukola Oluyide,2 Maria Keramarou,1 Rebecca Grais11Epicentre, Paris, France; 2Médecins Sans Frontières, Paris, FranceObjective: To explore traditional herbal medicines as potential risk factors of severe preeclampsia and eclampsia in Nigeria.Methods: We conducted a retrospective case-control study from October 2010 to May 2011. The cases were all pregnant women admitted to the Jahun Hospital during the study period with severe preeclampsia or eclampsia and women presenting with normal pregnancy after 22 weeks.Results: During the study period, a total of 1,257 women (44% were recorded as having normal pregnancy, and 419 (16% women had severe preeclampsia/eclampsia (175 with severe preeclampsia and 244 with eclampsia. The risk factors found to be associated with a greater risk of severe preeclampsia/eclampsia included personal history of preeclampsia (odds ratio [OR] = 21.5; P < 0.001, personal history of preexisting hypertension (OR = 10.5; P < 0.001, primiparity (OR = 2.5; P = 0.001, occupation as housewife (OR = 1.9; P = 0.008, and fewer than four antenatal care visits (OR = 1.6; P = 0.02. Use of traditional treatments during pregnancy was associated with a higher risk of developing severe preeclampsia/eclampsia (OR = 1.6 95%; confidence interval [CI]: 1.2-2.1 by univariate analysis only.Conclusion: Use of traditional treatment, which increases delays before consulting the official health sector, might be a marker for harmful behavior. Community-based studies could provide additional information on the practice of herbal therapy in this population.Keywords: hypertensive disorders, pregnancy, traditional treatments, herbal use

  10. The Relationship between Preeclampsia and Quadruple Screening Test in Nuliparous

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    Farnaz Zand Vakili

    2017-01-01

    Full Text Available Introduction: Early diagnosis and prediction of preeclampsia needs appropriate obstetric care. Preeclampsia predicting methods are important. This study was designed to determine the correlation between preeclampsia and quadruple screening test in the nulliparous. Materials and Methods:  This case - control study was conducted on 54 pregnant women with preeclampsia (case group and 108 healthy pregnant women (control group who referred to health centers in Sanandaj, Iran. Ultrasonography was performed to determine the gestational age by a radiologist. Maternal serum levels of alpha fetoprotein (AFP, human chorionic gonadotropin (hCG, unconjugated estriol (uE3, and inhibin-A were measured in the second trimester of pregnancy. Data were analyzed using SPSS statistical software and Chi-square test, T-test, sensitivity, specificity, positive and negative predictive values. Results: The results showed that the sensitivity and specificity for the diagnosis of preeclampsia in pregnant women for hCG were 35.2% and 79.6 respectively. These findings for estriol were 20.4% and 88.9%, for inhibin-A were 38.8% and 88% and for alpha fetoprotein were 38.8% and 74.1%. The positive predictive value for hCG, estriol, inhibin-A and alpha fetoprotein were 46.3%, 47.8%, 61.8% and 42.9% respectively. The negative predictive value for hCG, estriol, inhibin-A and alpha fetoprotein were also 71%, 69.1%, 74.2% and 70.8% respectively. Conclusion: There was a relationship between preeclampsia and high levels of inhibin-A and hCG. Further studies on these markers and evaluating their usefulness in the diagnosis and management of preeclampsia are recommended.

  11. Caracterización del riesgo familiar total de las familias con adulto mayor ubicadas en la Comuna Seis del municipio de Ibagué

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    Elizabeth Fajardo Ramos

    2008-01-01

    Conclusiones: Los factores que más aportaron al riesgo familiar fueron familias monoparentales, con mujeres cabeza de familia. La tendencia respecto a morbilidad fue encontrar más de un enfermo en la familia; la mortalidad fue baja. Las prácticas de salud mostraron ausencia de actividades recreativas, poco gratificantes, uso indiscriminado de tratamientos, prácticas perinatales inadecuadas en gestantes, ancianos inactivos y aislados.

  12. Vivências de gestantes e puérperas com o diagnóstico do HIV

    OpenAIRE

    Araújo, Maria Alix Leite; Silveira, Cláudia Bastos da; Silveira, Caroline Bastos da; Melo, Simone Paes de

    2008-01-01

    Identificar as experiências de gestantes e puérperas portadoras do HIV com a quimioprofilaxia para prevenção da transmissão vertical. Estudo de abordagem qualitativa desenvolvido nos meses de março e abril de 2006 em uma maternidade de referência de Fortaleza-Ceará. Os sujeitos foram gestantes e puérperas HIV positivas em acompanhamento pré-natal e no alojamento conjunto. A coleta de dados deu-se através de entrevista e a análise em três categorias: a revelação do diagnóstico aos familiares, ...

  13. The Norwegian preeclampsia family cohort study: a new resource for investigating genetic aspects and heritability of preeclampsia and related phenotypes.

    Science.gov (United States)

    Roten, Linda Tømmerdal; Thomsen, Liv Cecilie Vestrheim; Gundersen, Astrid Solberg; Fenstad, Mona Høysæter; Odland, Maria Lisa; Strand, Kristin Melheim; Solberg, Per; Tappert, Christian; Araya, Elisabeth; Bærheim, Gunhild; Lyslo, Ingvill; Tollaksen, Kjersti; Bjørge, Line; Austgulen, Rigmor

    2015-12-01

    Preeclampsia is a major pregnancy complication without curative treatment available. A Norwegian Preeclampsia Family Cohort was established to provide a new resource for genetic and molecular studies aiming to improve the understanding of the complex pathophysiology of preeclampsia. Participants were recruited from five Norwegian hospitals after diagnoses of preeclampsia registered in the Medical birth registry of Norway were verified according to the study's inclusion criteria. Detailed obstetric information and information on personal and family disease history focusing on cardiovascular health was collected. At attendance anthropometric measurements were registered and blood samples were drawn. The software package SPSS 19.0 for Windows was used to compute descriptive statistics such as mean and SD. P-values were computed based on t-test statistics for normally distributed variables. Nonparametrical methods (chi square) were used for categorical variables. A cohort consisting of 496 participants (355 females and 141 males) representing 137 families with increased occurrence of preeclampsia has been established, and blood samples are available for 477 participants. Descriptive analyses showed that about 60% of the index women's pregnancies with birth data registered were preeclamptic according to modern diagnosis criteria. We also found that about 41% of the index women experienced more than one preeclamptic pregnancy. In addition, the descriptive analyses confirmed that preeclamptic pregnancies are more often accompanied with delivery complications. The data and biological samples collected in this Norwegian Preeclampsia Family Cohort will provide an important basis for future research. Identification of preeclampsia susceptibility genes and new biomarkers may contribute to more efficient strategies to identify mothers "at risk" and contribute to development of novel preventative therapies.

  14. [Assessment of maternal cerebral blood flow in patients with preeclampsia].

    Science.gov (United States)

    Mandić, Vesna; Miković, Zeljko; Dukić, Milan; Vasiljević, Mladenko; Filimonović, Dejan; Bogavac, Mirjana

    2005-01-01

    Systemic vasoconstriction in preeclamptic patients increases vascular resistance, and is manifested by increased arterial blood flow velocity. The aim of the study is to evaluate if there is a change of Doppler indices in maternal medial cerbral artery (MCA) in severe preeclampsia due to: 1) severity of clinical symptoms, 2) the begining of eclamptic attack and 3) the application of anticonvulsive therapy. A prospective clinical study included 92 pregnant women, gestational age 28-36 weeks. They were divided into three groups: normotensive (n=30), mild preeclampsia (n=33), and severe preeclampsia (n=29). We investigated maternal cerebral circulation by assessing the MCA. We registrated: pulsatility index (Pi), resistance index (Ri), systolic/diastolic ratio (S/D), and the maximum systolic, end diastolic and medium velocity. Patients with severe preeclampsia were divided into two subgroups. subgroup 1 included patients without symptoms of threatening eclampsia (n=18; 62.06%); while subgroup 2 included those with symptoms of preeclampsia (n=11; 37.94%). All patients with severe preeclampsia were treated with magnesium sulfate (MgSO4), and cerebral blood flow was measured before and after the treatment. Statistical analysis was done by oneway ANOVA, Student t-test and t-paired sample test. The difference was considered to be significant if ppreclampsia we found increased velocity values, Pi and Ri, especially in patients with signs of threatened eclampsia, suggesting that blood vessels changes are most prominent in severe preeclampsia. Cerebral blood flow meassurements can be used as a clinical test for the prediction of eclampsia. Magnesium-sulfate (MgSO4) has a signifficant role in prophylaxis and treatment of eclampsia, and, therefore, positive influence on reduction of cerebral ishemic lesions can be expected. We can conclude that changes of the cerebral blood flow can be evaluated by evaluating blood flow velocities in the medial cerebral artery. Velocities tend

  15. App yo embarazo, una nueva forma de facilitar información a la gestante y su pareja

    OpenAIRE

    Amores Camacho, Sergio José; Ramírez Martínez, Elisa Isabel; Rodríguez Blanco, Noelia; Cazorla Amorós, Eduardo; Naranjo Fernández, Marta; Soriano, María Josefa

    2017-01-01

    Comunicación oral presentada en el 3er Congreso Internacional de Comunicación en Salud (3ICHC), celebrado los días 19 y 20 de octubre de 2017 en la Universidad Carlos III de Madrid. Los objetivos son mejorar los conocimientos y destrezas del cuidado de las gestantes, sus parejas y sus futuros recién nacidos, ofreciendo una información veraz, detallada y personalizada a las embarazadas y sus parejas

  16. 11β-Hydroxysteroid Dehydrogenase 2 in Preeclampsia

    Directory of Open Access Journals (Sweden)

    Katarzyna Kosicka

    2016-01-01

    Full Text Available Preeclampsia is a serious medical problem affecting the mother and her child and influences their health not only during the pregnancy, but also many years after. Although preeclampsia is a subject of many research projects, the etiology of the condition remains unclear. One of the hypotheses related to the etiology of preeclampsia is the deficiency in placental 11β-hydroxysteroid dehydrogenase 2 (11β-HSD2, the enzyme which in normal pregnancy protects the fetus from the excess of maternal cortisol. The reduced activity of the enzyme was observed in placentas from pregnancies complicated with preeclampsia. That suggests the overexposure of the developing child to maternal cortisol, which in high levels exerts proapoptotic effects and reduces fetal growth. The fetal growth restriction due to the diminished placental 11β-HSD2 function may be supported by the fact that preeclampsia is often accompanied with fetal hypotrophy. The causes of the reduced function of 11β-HSD2 in placental tissue are still discussed. This paper summarizes the phenomena that may affect the activity of the enzyme at various steps on the way from the gene to the protein.

  17. A novel marker in pregnant with preeclampsia: renalase.

    Science.gov (United States)

    Yılmaz, Zehra Vural; Akkaş, Elif; Yıldırım, Tolga; Yılmaz, Rahmi; Erdem, Yunus

    2017-04-01

    Preeclampsia is characterized by an increase in high blood pressure and decrease in GFR and proteinuria, however, the underlying mechanisms are still unclear. Renalase is a recently discovered protein implicated in regulation of blood pressure in humans. Plasma concentrations of serum renalase were measured in healthy controls, healthy pregnant and pregnant with preeclampsia matched for age, gestational age, in the third trimester of pregnancy. Serum renalase levels were compared in pregnant with and without preeclampsia and non-pregnant controls. Factors associated with serum renalase levels in pregnancies were also evaluated. In healthy pregnant serum renalase levels were significantly higher than in controls. However, pregnant with preeclampsia had lower renalase levels than healthy controls. Serum renalase levels were inversely associated with blood pressure levels and positively correlated with glomerular filtration rate. The results indicated that the development of preeclampsia in pregnant is accompanied by altered serum renalase levels. High blood pressure and kidney damage that characterize this disorder are mediated at least in part by low renalase levels.

  18. The modern features of pathogenesis-induced prevention of preeclampsia

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    Konkov D.G.

    2016-03-01

    Full Text Available Purpose — the assessment of clinical effectiveness of preventive therapy in pregnant women with high risk of preeclampsia. Patients and methods. In the comparative study on the effectiveness of preventive therapy were participated 110 pregnant women with decidual vasculopathy and endothelial dysfunction, which had high risk of preeclampsia. We investigated the clinical efficacy for medications that containing 75 mg of acetylsalicylic acid and L-arginine. Results. The results of the study have shown that use of preventive treatment (L-arginine and acetylsalicylic acid from 12 weeks, among pregnant women with high risk of preeclampsia, led to a significant decrease of perinatal loss, reduction of clinical manifestations of preeclampsia, preterm delivery, malformations and malpresentation of the placenta, cases of asphyxia of the newborns, perinatal CNS lesions and intra-ventricular hemorrhage. Conclusions. Clinical effectiveness of preventive treatment (L-arginine and ASA among pregnant women with high risk of preeclampsia was proven. Furthermore it was recognized clinically effective use of 75 mg of ASA from 12 weeks of pregnancy. No side effects of drugs in the study were noted.

  19. Preeclampsia: Reflections on How to Counsel About Preventing Recurrence.

    Science.gov (United States)

    Costa, Maria Laura

    2015-10-01

    Preeclampsia is one of the most challenging diseases of pregnancy, with unclear etiology, no specific marker for prediction, and no precise treatment besides delivery of the placenta. Many risk factors have been identified, and diagnostic and management tools have improved in recent years. However, this disease remains one of the leading causes of maternal morbidity and mortality worldwide, especially in under-resourced settings. A history of previous preeclampsia is a known risk factor for a new event in a future pregnancy, with recurrence rates varying from less than 10% to 65%, depending on the population or methodology considered. A recent review that performed an individual participant data meta-analysis on the recurrence of hypertensive disorders of pregnancy in over 99 000 women showed an overall recurrence rate of 20.7%; when specifically considering preeclampsia, it was 13.8%, with milder disease upon recurrence. Prevention of recurrent preeclampsia has been attempted by changes in lifestyle, dietary supplementation, antihypertensive drugs, antithrombotic agents, and others, with much uncertainty about benefit. It is always challenging to treat and counsel a woman with a previous history of preeclampsia; this review will be based on hypothetical clinical cases, using common scenarios in obstetrical practice to consider the available evidence on how to counsel each woman during pre-conception and prenatal consultations.

  20. Preeclampsia and retinopathy of prematurity in preterm births.

    Science.gov (United States)

    Yu, Xiao Dan; Branch, D Ware; Karumanchi, S Ananth; Zhang, Jun

    2012-07-01

    The relationship between gestational hypertension, preeclampsia, and the risk of retinopathy of prematurity (ROP) remains unclear. Thus, we used a large cohort database to study the influence of maternal gestational hypertension and preeclampsia on the occurrence of ROP in preterm infants. We used data from a previous retrospective cohort study that includes 25,473 eligible preterm neonates. We examined the association between gestational hypertension, preeclampsia, and ROP while controlling for potential confounders by multiple logistic regression analysis. Of the 8758 early preterm infants (gestational age <34 weeks), 1024 (11.69%) had ROP, while of the 16,715 late preterm infants, only 29 (0.17%) had ROP. After adjusting for confounders, preeclampsia was associated with a significantly reduced risk of ROP (adjusted odds ratio [aOR], 0.65; 95% confidence interval [CI], 0.49-0.86 for early preterm birth; aOR, 0.10; 95% CI, 0.01-0.93 for late preterm birth; aOR, 0.66; 95% CI, 0.50-0.87 for all preterm births). Gestational hypertension was not significantly associated with ROP at early or late preterm births. Preeclampsia, but not gestational hypertension, was associated with a reduced risk of ROP in preterm births.

  1. Estudo do diagnóstico de enfermagem fadiga em gestantes atendidas numa unidade básica de atenção à saúde Estudio del diagnóstico de enfermería fatiga en gestantes atendidas en una unidad básica de atencíon a la salud Study of nursing diagnosis fatigue among pregnant women from a primary care unit

    Directory of Open Access Journals (Sweden)

    Viviane Moreira Alves

    2006-03-01

    Full Text Available OBJETIVO: Analisar o diagnóstico de enfermagem Fadiga em gestantes. MÉTODOS: Estudo transversal com 66 gestantes. Os dados foram coletados através de um roteiro estruturado de entrevista e exame físico. Para a análise foram geradas estatísticas descritivas com a freqüência absoluta e percentual e aplicados testes de associação. RESULTADOS: Do total, 72,7% apresentaram o diagnóstico de enfermagem Fadiga. As características definidoras mais citadas foram: Aumento das queixas físicas (78,8%, Sonolência Ambiente barulhento (66,7% e Cansaço (65,2%, e os fatores relacionados que estiveram mais presentes na amostra foram Estilo de vida enfadonho (54,5%, Ansiedade (45,5% e Anemia (40,9%. CONCLUSÃO: O diagnóstico Fadiga apresenta determinadas características e fatores relacionados importantes, que devem ser foco da atenção por parte dos enfermeiros.OBJETIVO: Analizar el diagnóstico de enfermería Fatiga en gestantes. MÉTODOS: Estudio transversal realizado con 66 gestantes. Los datos fueron recolectados a través de una guía estructurada de entrevista y examen físico. Para el análisis se generaron estadísticas descriptivas con la frecuencia absoluta y porcentual y se aplicaron pruebas de asociación. RESULTADOS: Del total, 72,7% presentaron el diagnóstico de enfermería Fatiga. Las características definidoras más citadas fueron: Aumento de las quejas físicas (78,8%, Somnolencia, ambiente bullicioso (66,7% y Cansancio (65,2%, y los factores relacionados que estuvieron más presentes en la muestra fueron Estilo de vida aburrido (54,5%, Ansiedad (45,5% y Anemia (40,9%. CONCLUSIÓN: El diagnóstico Fatiga presenta determinadas características y factores relacionados importantes, que deben ser foco de atención de los enfermeros.AIM: To analyze the nursing diagnosis "fatigue" in pregnant women. METHODS: A cross-sectional descriptive design was used to conduct this study. Data were collected from 66 pregnant women using structured

  2. ALTO DÉFICIT DE CONOCIMIENTOS Y PERCEPCIONES ADECUADAS SOBRE ALIMENTACIÓN EN GESTANTES DEL HOSPITAL APOYO IQUITOS, 2012

    Directory of Open Access Journals (Sweden)

    Irene Paima

    2012-12-01

    Full Text Available Los conocimientos y percepciones sobre los alimentos ingeridos en la gestación tienen una vital importancia porque dependiendo de una buena alimentación en esta etapa, periodo en el que se incrementan notablemente las necesidades nutritivas para el beneficio del binomio madre – feto, será de mayor ayuda para prevenir en cada nueva gestación un déficit nutricional. Se realizó un estudio de descriptivo y transversal, la población estuvo conformada por todas las gestantes que acudieron al servicio de control pre natal del Hospital Iquitos Cesar Garay García. La muestra fue de 220 gestantes se utilizó un cuestionario validado por expertos. Se evidenció un alto porcentaje de conocimiento deficiente (43% sobre alimentación y percepciones inadecuadas (65% sobre alimentación en las gestantes de nuestro estudio. Se evidencia la necesidad de mejorar  el conocimiento sobre los alimentos importantes para presentar una gestación saludable. 

  3. ALTO DÉFICIT DE CONOCIMIENTOS Y PERCEPCIONES ADECUADAS SOBRE ALIMENTACIÓN EN GESTANTES DEL HOSPITAL APOYO IQUITOS, 2012

    Directory of Open Access Journals (Sweden)

    Irene Paima

    2012-12-01

    Full Text Available Los conocimientos y percepciones sobre los alimentos ingeridos en la gestación tienen una vital importancia porque dependiendo de una buena alimentación en esta etapa, periodo en el que se incrementan notablemente las necesidades nutritivas para el beneficio del binomio madre – feto, será de mayor ayuda para prevenir en cada nueva gestación un déficit nutricional. Se realizó un estudio de descriptivo y transversal, la población estuvo conformada por todas las gestantes que acudieron al servicio de control pre natal del Hospital Iquitos Cesar Garay García. La muestra fue de 220 gestantes se utilizó un cuestionario validado por expertos. Se evidenció un alto porcentaje de conocimiento deficiente (43% sobre alimentación y percepciones inadecuadas (65% sobre alimentación en las gestantes de nuestro estudio. Se evidencia la necesidad de mejorar el conocimiento sobre los alimentos importantes para presentar una gestación saludable.

  4. Prevalence of chronic kidney disease after preeclampsia.

    Science.gov (United States)

    Lopes van Balen, Veronica Agatha; Spaan, Julia Jeltje; Cornelis, Tom; Spaanderman, Marc Erich August

    2017-06-01

    Preeclampsia (PE), an endothelial disease that affects kidney function during pregnancy, is correlated to an increased future risk of cardiovascular and chronic kidney disease. The Kidney Disease Improving Global Outcomes (KDIGO) 2012 guideline emphasizes the combined role of glomerular filtration rate (GFR) and albuminuria in determining the frequency of monitoring of kidney function. In this study we evaluated the prevalence of CKD in women with a history of PE. We investigated how many seemingly healthy women required monitoring of kidney function according to the KDIGO guideline. We included 775 primiparous women with a history of PE. They were at least 4 months postpartum, and had no pre-existing hypertension, diabetes or kidney disease. We estimated GFR by the CKD-Epidemiology equation and urinary albumin loss by albumin creatinine ratio in a 24-h urine collection. Most women, 669 (86.3 %), had a normal GFR and absent albuminuria. Based on the KDIGO guideline, 13.7 % would require at least yearly monitoring of kidney function. Only 1.4 % were classified to be at high risk for kidney function deterioration. Monitoring of kidney function seems relevant for about one in seven women with a history of PE, mainly due to albuminuria. Albuminuria should be evaluated postpartum to identify those women that need further monitoring of kidney function.

  5. Pathogenesis of Preeclampsia: The Genetic Component

    Directory of Open Access Journals (Sweden)

    Francisco J. Valenzuela

    2012-01-01

    Full Text Available Preeclampsia (PE is one of the main causes of maternal and fetal morbidity and mortality in the world, causing nearly 40% of births delivered before 35 weeks of gestation. PE begins with inadequate trophoblast invasion early in pregnancy, which produces an increase in oxidative stress contributing to the development of systemic endothelial dysfunction in the later phases of the disease, leading to the characteristic clinical manifestation of PE. Numerous methods have been used to predict the onset of PE with different degrees of efficiency. These methods have used fetal/placental and maternal markers in different stages of pregnancy. From an epidemiological point of view, many studies have shown that PE is a disease with a strong familiar predisposition, which also varies according to geographical, socioeconomic, and racial features, and this information can be used in the prediction process. Large amounts of research have shown a genetic association with a multifactorial polygenic inheritance in the development of this disease. Many biological candidate genes and polymorphisms have been examined in their relation with PE. We will discuss the most important of them, grouped by the different pathogenic mechanisms involved in PE.

  6. Maternal Preeclampsia and Androgens in the Offspring around Puberty: A Follow-Up Study.

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    Ingvild V Alsnes

    Full Text Available Children born after preeclampsia may have a dominant androgen profile in puberty compared with other children. Circulating androgen concentrations at 11-12 years of age were compared between offspring born after preeclampsia, and children whose mothers did not have preeclampsia.A total of 611 mother-offspring pairs were followed up 11 (daughters or 12 (sons years after birth: 218 pairs in the preeclampsia group, and 383 pairs without preeclampsia. Circulating total testosterone, androstenedione, dehydroepiandrosterone sulfate (DHEAS, and insulin-like growth factor I (IGF-I were measured in the children. In boys, testicular volume was also measured.Among girls born after preeclampsia, DHEAS concentrations were higher than in unexposed girls (p<0.001, however, girls born after preeclampsia with severe features had the lowest DHEAS levels. In contrast, testosterone concentrations were highest in girls born after preeclampsia with severe features, both compared to other girls in the preeclampsia group, and compared to unexposed girls (p<0.001. For boys, testosterone concentrations were higher in the preeclampsia group compared with unexposed boys (p<0.001, and boys born after preeclampsia with severe features had the lowest concentrations of DHEAS. Compared with unexposed boys, testicular volume (p = 0.015 and IGF-I (p = 0.004 were higher for boys in the preeclampsia group, except for boys in the clinically severe preeclampsia group.In utero exposure to preeclampsia is associated with androgen hormonal patterns in early puberty that depend on clinical severity of preeclampsia and sex of the offspring. The hormonal differences may reflect different timing of pubertal development, and may have consequences for future health of the offspring.

  7. Serum Leptin Measured in Early Pregnancy Is Higher in Women With Preeclampsia Compared With Normotensive Pregnant Women

    DEFF Research Database (Denmark)

    Taylor, Brandie; Ness, Roberta B; Olsen, Jørn

    2015-01-01

    Leptin, an adipocyte-derived hormone, plays an important role in reproduction and angiogenesis. Studies examining leptin in preeclampsia are inconsistent, possibly because of small sample sizes and variability in sampling and outcome. We conducted a nested case-control study to examine associations...... between serum leptin (measured: 9-26 weeks gestation) and preeclampsia among 430 primiparous preeclamptic women and 316 primiparous normotensive controls from the Danish National Birth Cohort. Median (interquartile range) leptin concentrations were calculated. Associations between leptin and preeclampsia...... (blood pressure ≥140/90 mm Hg), term preeclampsia (preeclampsia and delivery ≥37 weeks gestation), or preterm preeclampsia (preeclampsia and delivery

  8. Diagnostic criteria and reporting procedures for pre-eclampsia

    DEFF Research Database (Denmark)

    Klemmensen, Ase K; Olsen, Sjurdur F.; Wengel, Christina M

    2005-01-01

    OBJECTIVE: A precondition for the rational use of obstetric databases in biomedical research is detailed knowledge on how data are being generated. We identified the diagnostic procedures and criteria for pre-eclampsia (PE) and assessed the level of obstetric training of the personnel responsible...... of pregnancy diagnoses to the National Patient Registry differed widely in training. For complicated pregnancies, departments ranged from having only specialists reporting all cases to secretaries reporting up to 50%. Cut off limits of blood pressure (BP) and protein loss used to diagnose pre-eclampsia showed...... large differences across departments. The diagnoses given to three case stories showed little correlation to the criteria the departments reported using. CONCLUSION: Even in a small country like Denmark with 34 obstetrical departments, there was little consensus on the diagnostic criteria for pre-eclampsia...

  9. Extra vitamin D from fortification and the risk of preeclampsia

    DEFF Research Database (Denmark)

    Stougaard, Maria; Damm, Peter; Frederiksen, Peder

    2018-01-01

    The objective of the study was to examine if exposure to extra vitamin D from food fortification was associated with a decrease in the risk of preeclampsia. The study was based on a natural experiment exploring the effect of the abolition of the Danish mandatory vitamin D fortification of margarine...... in 1985. The effect of the extra vitamin D (1.25μg vitamin D/100 g margarine) was examined by comparing preeclampsia risk in women who have been exposed or unexposed to extra vitamin D from the fortified margarine during pregnancy, and who gave birth in the period from June 1983 to August 1988. The Danish...... National Patient Registry allowed the identification of pregnancies complicated by preeclampsia. The study included 73,237 women who gave birth during 1983-1988. We found no association between exposure to vitamin D fortification during pregnancy and the risk of any of the pregnancy related hypertensive...

  10. Severe Preeclampsia in the Setting of Myasthenia Gravis

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    Adam J. Lake

    2017-01-01

    Full Text Available Myasthenia gravis (MG is a rare autoimmune disease that leads to progressive muscle weakness and is common during female reproductive years. The myasthenic mother and her newborn must be observed carefully, as complications during all stages of pregnancy and the puerperium may arise suddenly. Preeclampsia is a common obstetrical condition for which magnesium sulfate is used for seizure prophylaxis. However, magnesium sulfate is strongly contraindicated in MG as it impairs already slowed nerve-muscle connections. Similarly, many first-line antihypertensive medications, including calcium channels blockers and β-blockers, may lead to MG exacerbation. This case describes the effective obstetrical management of a patient with MG who developed severe preeclampsia. The effective use of levetiracetam and various antihypertensive medications including intravenous labetalol is described. A review of the ten reported cases of MG complicated by preeclampsia is examined to aggregate observations of clinical care, with focus on delivery methods, anticonvulsants, and antihypertensive medications.

  11. Disfunción endotelial en la preeclampsia

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    José Pacheco Romero

    2003-03-01

    Full Text Available Desconocemos aún la etiología de la preeclampsia, pero ahora sabemos que no es sólo una hipertensión inducida por el embarazo, sino que existe interacción entre una perfusión placentaria disminuida y la alteración en la función endotelial materna, probablemente por razones inmunológicas de rechazo parcial a la placentación normal. La contribución materna es de factores que anteceden al embarazo, influenciados por las adaptaciones metabólicas usuales. No existe un gen único que pueda explicar la preeclampsia, pero conocer la predisposición materna permite prevenir la preeclampsia en un grupo de mujeres.

  12. Prediction of the preeclampsia: a view of biochemical markers

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    Mehmet Sühha Bostancı

    2013-10-01

    Full Text Available Preeclampsia is a diverse, multiorgan group of related disease processes that occurs in up to 5%-8% of pregnancies after 20 weeks’ gestation and it is one of the leading causes of maternal and fetal morbidity and mortality. Many molecular mechanisms are contributed to the pathogenesis of preeclampsia. Although it is unknown whether the mechanisms act independently or have synergistic effects. This review describes review of primary papers investigating blood based biomarker such as PAP-A, Inhibin A, sFlt1, and PP13 in general and first trimester biochemical markers and combinations of them specifically for preeclampsia.http://dx.doi.org/10.7175/rhc.v4i4.699

  13. La pérdida y el abandono en gestantes desplazadas-Bogotá The feeling of loss and abandonment among pregnant displaced women -Bogotá

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    MARÍA CARMEN BERNAL ROLDÁN

    2007-12-01

    Full Text Available Esta investigación se basa en la problemática de la población desplazada de nuestro país, específicamente de mujeres gestantes desplazadas, y en la línea de investigación Cuidado Materno Perinatal desde la Enfermería Transcultural de la Facultad de Enfermería, de la Universidad Nacional de Colombia. Se tuvo en cuenta la teoría del cuidado transcultural de Leininger (1978,la cual considera que el ser humano está inmerso en una red de relaciones sociales y situado en un determinado contexto, aspectos estos que permean su comportamiento, es decir, la cultura en la cual él crece y vive hace parte de sus prácticas de cuidado. Se usó el método de la etnoenfermería propuesto por Leininger (1985, con el objetivo de explorar el significado que tienen las gestantes desplazadas del cuidado de sí y de su hijo por nacer, desde lo émic punto de vista del nativo, en Bogotá (Localidades de Suba y Ciudad Bolívar. Las participantes fueron desplazadas de los departamentos de Tolima, Arauca, Cundinamarca, Caquetá, Bolívar, Guainía y Cauca, cuyas edades oscilaron entre los 14 y los 34 años, y el tiempo de desplazamiento estuvo entre los dos meses y un año. Los datos se obtuvieron por entrevista individual y grupal (doce participantes y por observación, y se aplicó el análisis etnográfico de Spradley (1980: dominios (categorías de significado que incluye otras categorías menores con sus relaciones semánticas, taxonomía (conjunto de categorías, análisis componencial (búsqueda de atributos asociados con símbolos culturales y temas (el más alto nivel de abstracción. Se obtuvo el tema El surgimiento de la esperanza en medio de la dificultad del desplazamiento de la gestante, con los subtemas: La pérdida y el abandono y El camino a seguir.This research concentrates on the displaced population of our country, specifically pregnant displaced women, and along the research line of Prenatal Maternal Care from the nursing Faculty of the

  14. Heart Rate Variability and Autonomic Modulations in Preeclampsia.

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    Shaza M Musa

    Full Text Available Although the exact pathophysiology of preeclampsia is not well understood, autonomic nervous system imbalance is suggested as one of the main factors.To investigate heart rate variability (HRV and autonomic modulations in Sudanese pregnant women with preeclampsia.A case-control study (60 women in each arm was conducted at Omdurman Maternity Hospital-Sudan, during the period from June to August, 2014. Cases were women presented with preeclampsia and healthy pregnant women were the controls. Studied groups were matched for important determinants of HRV. Natural logarithm (Ln of total power (TP, high frequency (HF, low frequency (LF and very low frequency (VLF were used to determine HRV. Normalized low and high frequencies (LF Norm and HF Norm were used to evaluate sympathetic and parasympathetic autonomic modulations respectively.Patients with preeclampsia achieved significantly higher LF Norm [49.80 (16.25 vs. 44.55 (19.15, P = 0.044] and LnLF/HF [0.04 (0.68 vs. -0.28 (0.91, P = 0.023] readings, but lower HF Norm [49.08 (15.29 vs. 55.87 (19.56, P = 0.012], compared with healthy pregnant women. Although all other HRV measurements were higher in the patients with preeclampsia compared with the controls, only LnVLF [4.50 (1.19 vs. 4.01 (1.06, P = 0.017] and LnLF [4.01 (1.58 vs. 3.49 (1.23, P = 0.040] reached statistical significance.The study adds further evidence for the dominant cardiac sympathetic modulations on patients with preeclampsia, probably secondary to parasympathetic withdrawal in this group. However, the higher LnVLF and LnLF readings achieved by preeclamptic women compared with the controls are unexpected in the view that augmented sympathetic modulations usually depresses all HRV parameters including these two measures.

  15. Cardiac diastolic function after recovery from pre-eclampsia.

    Science.gov (United States)

    Soma-Pillay, P; Louw, M C; Adeyemo, A O; Makin, J; Pattinson, R C

    Pre-eclampsia is associated with significant changes to the cardiovascular system during pregnancy. Eccentric and concentric remodelling of the left ventricle occurs, resulting in impaired contractility and diastolic dysfunction. It is unclear whether these structural and functional changes resolve completely after delivery. The objective of the study was to determine cardiac diastolic function at delivery and one year post-partum in women with severe pre-eclampsia, and to determine possible future cardiovascular risk. This was a descriptive study performed at Steve Biko Academic Hospital, a tertiary referral hospital in Pretoria, South Africa. Ninety-six women with severe preeclampsia and 45 normotensive women with uncomplicated pregnancies were recruited during the delivery admission. Seventy-four (77.1%) women in the pre-eclamptic group were classified as a maternal near miss. Transthoracic Doppler echocardiography was performed at delivery and one year post-partum. At one year post-partum, women with pre-eclampsia had a higher diastolic blood pressure (p = 0.001) and body mass index (p = 0.02) than women in the normotensive control group. Women with early onset pre-eclampsia requiring delivery prior to 34 weeks' gestation had an increased risk of diastolic dysfunction at one year post-partum (RR 3.41, 95% CI: 1.11-10.5, p = 0.04) and this was irrespective of whether the patient had chronic hypertension or not. Women who develop early-onset pre-eclampsia requiring delivery before 34 weeks are at a significant risk of developing cardiac diastolic dysfunction one year after delivery compared to normotensive women with a history of a low-risk pregnancy.

  16. Role of uterine artery doppler ultrasound in predicting preeclampsia primigravida

    International Nuclear Information System (INIS)

    Awan, F.; Ullah, H.

    2016-01-01

    Objective: To find the accuracy of uterine artery diastolic notching during the second trimester of pregnancy in predicting pre-eclampsia in primigravida patients. Study Design: Descriptive cross sectional study. Place and Duration of Study: Armed Forces Institute of Radiology and Imaging (AFIRI) Rawalpindi; six months duration from 30 Nov 2012 to 31 May 2013. Material and Methods: This study included 199 primigravida women with singleton pregnancy having diastolic notch in uterine arteries between 20 to 23 weeks of gestation. All patients were examined by both grey scale and doppler ultrasonography. Uterine arteries were evaluated with doppler near the point where they crossed the external iliac arteries. The patient was included in study if the presence of diastolic notch was demonstrated. Clinical follow up in gynae and obs department continued throughout the pregnancy to see if they developed preeclampsia. The data were recorded on a previously prepared proforma and analyzed with SPSS 21. Results: The accuracy of uterine artery doppler ultrasound in identifying women who later developed preeclampsia was 48.24 percent. The frequency of pre-eclampsia with bilateral notch was significantly high in the primigravid of younger age as compare to the primigravid of the older group (p=0.001). The difference in frequency of developing pre-eclampsia with bilateral notch when compared among 20 to 21 week gestational age and 22 to 23 weeks gestational age was statistically insignificant. Conclusion: Uterine artery diastolic notching between 20 and 23 weeks of gestation is an important risk factor for developing pre-eclampsia. This doppler parameter should, therefore, be included in the risk evaluation for gestational hypertension. (author)

  17. Preeclampsia and health risks later in life: an immunological link.

    Science.gov (United States)

    Cheng, Shi-Bin; Sharma, Surendra

    2016-11-01

    Pregnancy represents a period of physiological stress, and although this stress is experienced for a very modest portion of life, it is now recognized as a window to women's future health, often by unmasking predispositions to conditions that only become symptomatic later in life. In normal pregnancy, the mother experiences mild metabolic syndrome-like condition through week 20 of gestation. A pronounced phenotype of metabolic syndrome may program pregnancy complications such as preeclampsia. Preeclampsia is a serious complication with a myriad of manifestations for mother and offspring. This pregnancy syndrome is a polygenic disease and has been now linked to higher incidence of cardiovascular disease, diabetes, and several other disorders associated with vulnerable organs. Furthermore, the offspring born to preeclamptic mothers also exhibit an elevated risk of cardiovascular disease, stroke, and mental disorders during adulthood. This suggests that preeclampsia not only exposes the mother and the fetus to complications during pregnancy but also programs chronic diseases in later life. The etiology of preeclampsia is thought to be primarily associated with poor placentation and entails excessive maternal inflammation and endothelial dysfunction. It is well established now that the maternal immune system and the placenta are involved in a highly choreographed cross-talk that underlies adequate spiral artery remodeling required for uteroplacental perfusion and free flow of nutrients to the fetus. Since normal pregnancy is associated with a sequence of events represented by temporal events of inflammation (implantation), anti-inflammation (gestation), and inflammation (parturition), it is quite possible that unscheduled alterations in these regulatory responses may lead to pathologic consequences. Although it is not clear whether immunological alterations occur early in pregnancy, it is proposed that dysregulated systemic and placental immunity contribute to impaired

  18. Robust early pregnancy prediction of later preeclampsia using metabolomic biomarkers.

    LENUS (Irish Health Repository)

    Kenny, Louise C

    2012-01-31

    Preeclampsia is a pregnancy-specific syndrome that causes substantial maternal and fetal morbidity and mortality. The etiology is incompletely understood, and there is no clinically useful screening test. Current metabolomic technologies have allowed the establishment of metabolic signatures of preeclampsia in early pregnancy. Here, a 2-phase discovery\\/validation metabolic profiling study was performed. In the discovery phase, a nested case-control study was designed, using samples obtained at 15+\\/-1 weeks\\' gestation from 60 women who subsequently developed preeclampsia and 60 controls taking part in the prospective Screening for Pregnancy Endpoints cohort study. Controls were proportionally population matched for age, ethnicity, and body mass index at booking. Plasma samples were analyzed using ultra performance liquid chromatography-mass spectrometry. A multivariate predictive model combining 14 metabolites gave an odds ratio for developing preeclampsia of 36 (95% CI: 12 to 108), with an area under the receiver operator characteristic curve of 0.94. These findings were then validated using an independent case-control study on plasma obtained at 15+\\/-1 weeks from 39 women who subsequently developed preeclampsia and 40 similarly matched controls from a participating center in a different country. The same 14 metabolites produced an odds ratio of 23 (95% CI: 7 to 73) with an area under receiver operator characteristic curve of 0.92. The finding of a consistent discriminatory metabolite signature in early pregnancy plasma preceding the onset of preeclampsia offers insight into disease pathogenesis and offers the tantalizing promise of a robust presymptomatic screening test.

  19. Robust Early Pregnancy Prediction of Later Preeclampsia Using Metabolomic Biomarkers.

    LENUS (Irish Health Repository)

    Kenny, Louise C

    2010-09-13

    Preeclampsia is a pregnancy-specific syndrome that causes substantial maternal and fetal morbidity and mortality. The etiology is incompletely understood, and there is no clinically useful screening test. Current metabolomic technologies have allowed the establishment of metabolic signatures of preeclampsia in early pregnancy. Here, a 2-phase discovery\\/validation metabolic profiling study was performed. In the discovery phase, a nested case-control study was designed, using samples obtained at 15±1 weeks\\' gestation from 60 women who subsequently developed preeclampsia and 60 controls taking part in the prospective Screening for Pregnancy Endpoints cohort study. Controls were proportionally population matched for age, ethnicity, and body mass index at booking. Plasma samples were analyzed using ultra performance liquid chromatography-mass spectrometry. A multivariate predictive model combining 14 metabolites gave an odds ratio for developing preeclampsia of 36 (95% CI: 12 to 108), with an area under the receiver operator characteristic curve of 0.94. These findings were then validated using an independent case-control study on plasma obtained at 15±1 weeks from 39 women who subsequently developed preeclampsia and 40 similarly matched controls from a participating center in a different country. The same 14 metabolites produced an odds ratio of 23 (95% CI: 7 to 73) with an area under receiver operator characteristic curve of 0.92. The finding of a consistent discriminatory metabolite signature in early pregnancy plasma preceding the onset of preeclampsia offers insight into disease pathogenesis and offers the tantalizing promise of a robust presymptomatic screening test.

  20. Aspirin for Evidence-Based Preeclampsia Prevention trial: influence of compliance on beneficial effect of aspirin in prevention of preterm preeclampsia.

    Science.gov (United States)

    Wright, David; Poon, Liona C; Rolnik, Daniel L; Syngelaki, Argyro; Delgado, Juan Luis; Vojtassakova, Denisa; de Alvarado, Mercedes; Kapeti, Evgenia; Rehal, Anoop; Pazos, Andrea; Carbone, Ilma Floriana; Dutemeyer, Vivien; Plasencia, Walter; Papantoniou, Nikos; Nicolaides, Kypros H

    2017-12-01

    The Aspirin for Evidence-Based Preeclampsia Prevention trial was a multicenter study in women with singleton pregnancies. Screening was carried out at 11-13 weeks' gestation with an algorithm that combines maternal factors and biomarkers (mean arterial pressure, uterine artery pulsatility index, and maternal serum pregnancy-associated plasma protein A and placental growth factor). Those with an estimated risk for preterm preeclampsia of >1 in 100 were invited to participate in a double-blind trial of aspirin (150 mg/d) vs placebo from 11-14 until 36 weeks' gestation. Preterm preeclampsia with delivery at preeclampsia in the Aspirin for Evidence-Based Preeclampsia Prevention trial. This was a secondary analysis of data from the trial. The proportion of prescribed tablets taken was used as an overall measure of compliance. Logistic regression analysis was used to estimate the effect of aspirin on the incidence of preterm preeclampsia according to compliance of preeclampsia at screening and the participating center. The choice of cut-off of 90% was based on an exploratory analysis of the treatment effect. Logistic regression analysis was used to investigate predictors of compliance ≥90% among maternal characteristics and medical history. Preterm preeclampsia occurred in 5/555 (0.9%) participants in the aspirin group with compliance ≥90%, in 8/243 (3.3%) of participants in the aspirin group with compliance preeclampsia was 0.24 (95% confidence interval, 0.09-0.65) for compliance ≥90% and 0.59 (95% confidence interval, 0.23-1.53) for compliance preeclampsia and negatively associated with smoking, maternal age preeclampsia in a previous pregnancy. The beneficial effect of aspirin in the prevention of preterm preeclampsia appears to depend on compliance. Copyright © 2017 Elsevier Inc. All rights reserved.

  1. Renal Involvement in Preeclampsia: Similarities to VEGF Ablation Therapy

    Directory of Open Access Journals (Sweden)

    Janina Müller-Deile

    2011-01-01

    Full Text Available Glomerular VEGF expression is critical for the maintenance and function of an intact filtration barrier. Alterations in glomerular VEGF bioavailability result in endothelial as well as in podocyte damage. Renal involvement in preeclampsia includes proteinuria, podocyturia, elevated blood pressure, edema, glomerular capillary endotheliosis, and thrombotic microangiopathy. At least the renal signs, symptoms, and other evidence can sufficiently be explained by reduced VEGF levels. The aim of this paper was to summarize our pathophysiological understanding of the renal involvement of preeclampsia and point out similarities to the renal side effects of VEGF-ablation therapy.

  2. Elevated Adenosine Induces Placental DNA Hypomethylation Independent of A2B Receptor Signaling in Preeclampsia.

    Science.gov (United States)

    Huang, Aji; Wu, Hongyu; Iriyama, Takayuki; Zhang, Yujin; Sun, Kaiqi; Song, Anren; Liu, Hong; Peng, Zhangzhe; Tang, Lili; Lee, Minjung; Huang, Yun; Ni, Xin; Kellems, Rodney E; Xia, Yang

    2017-07-01

    Preeclampsia is a prevalent pregnancy hypertensive disease with both maternal and fetal morbidity and mortality. Emerging evidence indicates that global placental DNA hypomethylation is observed in patients with preeclampsia and is linked to altered gene expression and disease development. However, the molecular basis underlying placental epigenetic changes in preeclampsia remains unclear. Using 2 independent experimental models of preeclampsia, adenosine deaminase-deficient mice and a pathogenic autoantibody-induced mouse model of preeclampsia, we demonstrate that elevated placental adenosine not only induces hallmark features of preeclampsia but also causes placental DNA hypomethylation. The use of genetic approaches to express an adenosine deaminase minigene specifically in placentas, or adenosine deaminase enzyme replacement therapy, restored placental adenosine to normal levels, attenuated preeclampsia features, and abolished placental DNA hypomethylation in adenosine deaminase-deficient mice. Genetic deletion of CD73 (an ectonucleotidase that converts AMP to adenosine) prevented the elevation of placental adenosine in the autoantibody-induced preeclampsia mouse model and ameliorated preeclampsia features and placental DNA hypomethylation. Immunohistochemical studies revealed that elevated placental adenosine-mediated DNA hypomethylation predominantly occurs in spongiotrophoblasts and labyrinthine trophoblasts and that this effect is independent of A2B adenosine receptor activation in both preeclampsia models. Extending our mouse findings to humans, we used cultured human trophoblasts to demonstrate that adenosine functions intracellularly and induces DNA hypomethylation without A2B adenosine receptor activation. Altogether, both mouse and human studies reveal novel mechanisms underlying placental DNA hypomethylation and potential therapeutic approaches for preeclampsia. © 2017 American Heart Association, Inc.

  3. The reduction in circulating levels of melatonin may be associated with the development of preeclampsia.

    Science.gov (United States)

    Zeng, K; Gao, Y; Wan, J; Tong, M; Lee, A C; Zhao, M; Chen, Q

    2016-11-01

    Placental dysfunction and oxidative stress contribute to the pathogenesis of preeclampsia, which is a pregnancy-specific disorder. It has been suggested that the incidence of preeclampsia has a seasonal variation. Melatonin, as a seasonal factor, has been suggested to be involved in a successful pregnancy. In this study, we investigated the association of circulating levels of melatonin with preeclampsia. Serum was collected from women with preeclampsia (n=113) and gestation-matched healthy pregnant women, and the levels of melatonin were measured. In addition, the expression of melatonin receptors was examined in preeclamptic placentae (n=27). The association of the incidence of preeclampsia and seasonal variation was also analysed from 1491 women with preeclampsia within 77 745 healthy pregnancies. The serum levels of melatonin were significantly reduced in women with preeclampsia at presentation and these reduced serum levels of melatonin were not associated with the severity or time onset of preeclampsia nor with seasonal variation. The expression of melatonin receptor, MT1 was reduced in preeclamptic placentae. The incidence of preeclampsia was did exhibit seasonal variation, but this was largely due to the increase in the incidence of mild or late-onset preeclampsia. Our results demonstrate that reduced melatonin levels are associated with the development of preeclampsia but that the circulating levels of melatonin do not appear to be subject to seasonal variation during pregnancy.

  4. Association of Polymorphism in Gene of Pregnancy-Associated Plasma Protein A (PAPPA and Preeclampsia

    Directory of Open Access Journals (Sweden)

    Nasrin Moghaddam

    2018-02-01

    Full Text Available Background: Preeclampsia is a common disorder of pregnancy. Current study was conducted to determine the association of polymorphism in gene of pregnancy-associated plasma protein A (PAPPA and preeclampsia. Methods: In this prospective cohort study, 134 pregnant women were consecutively enrolled and the blood sampling was performed for genetic analysis in a single lab. Then the subjects were followed-up for preeclampsia and it was seen that 34 women developed preeclampsia and the polymorphism of PAPPA gene was compared between those with and without preeclampsia. Results: The results demonstrated that despite twice higher proportion of CC condition of PAPPA in those with preeclampsia in comparison with those with normal pregnancy, there was no significant difference between two groups (P > 0.05. Conclusions: Totally, according to the obtained results, it may be concluded that polymorphism of pregnancy-associated plasma protein A is not related to occurrence of preeclampsia in pregnant women.

  5. Long-term impact of preeclampsia on maternal endometrial cancer risk

    DEFF Research Database (Denmark)

    Hallum, Sara; Pinborg, Anja; Kamper-Jørgensen, Mads

    2016-01-01

    BACKGROUND: Endometrial cancer is mainly dependent on oestrogen exposure. Preeclampsia has shown to reduce oestrogen levels hence preeclampsia may affect later endometrial cancer risk. METHODS: We conducted a case-control study of 523 Danish women with endometrial cancer and 52 299controls during...... 1978-2010. The association between preeclampsia and later endometrial cancer was evaluated overall and according to preeclampsia onset and type of endometrial cancer in conditional logistic regression models. RESULTS: We observed no overall association between preeclampsia and endometrial cancer risk...... (OR=1.11 (95% CI 0.68-1.81)). This was true for all endometrial cancer subtypes. In an analysis of preeclampsia onset, however, we report a markedly increased risk of endometrial cancer following early-onset preeclampsia (OR=2.64 (95% CI 1.29-5.38)). CONCLUSIONS: Although we report no obvious...

  6. Differences in clinical presentation and pregnancy outcomes in antepartum preeclampsia and new-onset postpartum preeclampsia: Are these the same disorder?

    Science.gov (United States)

    Vilchez, Gustavo; Hoyos, Luis R; Leon-Peters, Jocelyn; Lagos, Moraima; Argoti, Pedro

    2016-11-01

    New-onset postpartum preeclampsia is a poorly defined condition that accounts for a significant percentage of eclampsia cases. It is unclear whether new-onset postpartum preeclampsia is a different disorder from or belongs to the same spectrum of classic antepartum preeclampsia. The objective of this study was to compare the clinical presentation and pregnancy outcomes of antepartum preeclampsia and new-onset postpartum preeclampsia. A retrospective study including 92 patients with antepartum preeclampsia and 92 patients with new-onset postpartum preeclampsia was performed. Clinical presentation and pregnancy outcomes were compared. Chi-square test was used to analyze categorical variables, and independent t -test and Mann-Whitney U -test for numerical variables. P -values of presentation, laboratory markers and pregnancy outcomes. New-onset postpartum preeclampsia has a distinct patient profile and clinical presentation than antepartum preeclampsia, suggesting they may represent different disorders. Characterization of a patient profile with increased risk of developing this condition will help clinicians to identify patients at risk and provide early and targeted interventions to decrease the morbidity associated with this condition.

  7. Tratamento da pré-eclâmpsia baseado em evidências Pre-eclampsia treatment according to scientific evidence

    Directory of Open Access Journals (Sweden)

    Carlos Noronha Neto

    2010-09-01

    Full Text Available As síndromes hipertensivas na gestação merecem especial destaque no cenário da saúde pública mundial. Atualmente, respondem como terceira causa de mortalidade materna no mundo e primeira no Brasil. Do ponto de vista prático, a pré-eclâmpsia continua sendo uma síndrome que leva a graves repercussões maternas e fetais, conhecendo-se ainda pouco sobre sua etiologia. Atualmente, tem-se discutido a melhor terapêutica para os quadros de pré-eclâmpsia em diversos momentos do ciclo gravídico-puerperal, visando sempre à redução de altos índices de morbimortalidade materna e fetal. O parto, considerando-se a fisiopatologia do evento, representa a melhor forma de tratamento. O uso de sulfato de magnésio é recomendado em todos os casos de pré-eclâmpsia grave e eclâmpsia para prevenção e tratamento das crises convulsivas. Da mesma forma, o tratamento dos picos hipertensivos é recomendado. Hidralazina, nifedipina e labetalol têm sido as drogas mais utilizadas com essa finalidade, mas seu uso dependente da familiaridade do médico assistente. A corticoterapia antenatal está indicada sempre que existe risco iminente de prematuridade entre a 24º e 34º semana. Em contrapartida, não há evidências suficientes para recomendar repouso e administração de expansores plasmáticos de rotina, assim como há necessidade urgente de ensaios clínicos randomizados para determinar se o tratamento anti-hipertensivo de manutenção nas gestantes apresenta benefícios ou riscos para mães e fetos, em todas as formas clínicas da doença, em particular nos casos de pré-eclâmpsia pura.Hypertensive disorders in pregnancy deserve special attention in the setting of global public health. Currently, they represent the third cause of maternal mortality in the world and first in Brazil. From a practical standpoint, pre-eclampsia remains a syndrome that leads to serious repercussions on maternal and fetal mortality and its etiology is not well known

  8. Competing risks model in screening for preeclampsia by maternal characteristics and medical history.

    Science.gov (United States)

    Wright, David; Syngelaki, Argyro; Akolekar, Ranjit; Poon, Leona C; Nicolaides, Kypros H

    2015-07-01

    The purpose of this study was to develop a model for preeclampsia based on maternal demographic characteristics and medical history. This was a screening study of 120,492 singleton pregnancies at 11-13 weeks' gestation, including 2704 pregnancies (2.2%) that experienced preeclampsia. A survival-time model for the gestational age at delivery with preeclampsia was developed from variables of maternal characteristics and history. This approach assumes that, if the pregnancy was to continue indefinitely, all women would experience preeclampsia and that whether they do so or not before a specified gestational age depends on competition between delivery before or after development of preeclampsia. A 5-fold cross validation study was conducted to compare the performance of the new model with the National Institute for Health and Clinical Excellence (NICE) guidelines. In the new model, increased risk for preeclampsia, with a consequent shift in the Gaussian distribution of the gestational age at delivery with preeclampsia to the left, is provided by advancing maternal age, increasing weight, Afro-Caribbean and South Asian racial origin, medical history of chronic hypertension, diabetes mellitus and systemic lupus erythematosus or antiphospholipid syndrome, family history and personal history of preeclampsia, and conception by in vitro fertilization. The risk for preeclampsia decreases with increasing maternal height and in parous women with no previous preeclampsia; in the latter, the protective effect, which is related inversely to the interpregnancy interval, persists beyond 15 years. At a screen-positive rate of 11%, as defined by NICE, the new model predicted 40%, 48%, and 54% of cases of total preeclampsia and preeclampsia requiring delivery at preeclampsia. Such estimation of the a priori risk for preeclampsia is an essential first step in the use of Bayes theorem to combine maternal factors with biomarkers for the continuing development of more effective methods of

  9. Avaliação do perfil de risco de cárie dentária em gestantes de Araraquara, Brasil Evaluación de factores de riesgo de padecer caries dental en gestantes de Araraquara, Brasil Evaluation of risk factors suffering dental caries in pregnants from Araraquara, Brazil

    Directory of Open Access Journals (Sweden)

    Tatiana Carolina De Aguiar

    2011-12-01

    Full Text Available O conhecimento do risco de cárie na gravidez é essencial para um correto plano de tratamento com ações educativas e preventivas às mães para que possam cuidar adequadamente de sua saúde bucal e de seus filhos. Este estudo retrospectivo teve como objetivo identificar o risco de cárie de gestantes (15-44 anos; média= 25 anos que frequentaram a clínica de odontologia preventiva da Faculdade de Odontologia de Araraquara, Universidade Estadual Paulista de 1999 a 2007. Um total de 166 prontuários, preenchidos por alunos do 3º ano do Curso de Graduação, seguindo orientações pré-estabelecidas, foram utilizados. Coletou-se informação sobre: classificação do diagnóstico de risco de cárie, trimestre gestacional, consumo de carboidratos (entre ou durante as refeições, placa corada (registro de controle de placa de O'Leary, número e grupo de dentes com experiência de cárie. Para análise estatística foram utilizados o teste de qui-quadrado e ANOVA. A maioria das gestantes (92,1 % apresentou 25 % ou mais das superfícies dentárias com placa dental. A média (desvio-padrão de dentes obturados e cariados foi 7,9 (5,1 e 4,0 (3,4, respectiva emente. Os dentes posteriores foram os mais acometidos por cárie/restaurações. Quanto ao diagnóstico de risco à cárie, a classificação alta foi observada em 38,5 % das gestantes, moderada em 47,6 % e baixa em 13,9 %. Houve associação estatisticamente significativa (p= 0,001 entre o consumo de carboidratos e o diagnóstico de risco de cárie. O índice de placa foi semelhante nos diferentes trimestres gestacionais (f= 0,223; p= 0,803. Portanto pode-se concluir que o risco de cárie da grande maioria das gestantes foi alto ou moderado e esteve estatisticamente associado ao consumo de carboidratos.El conocimiento del riesgo de padecer de caries dental durante el periodo de embarazo es esencial para un correcto plan de tratamiento con las acciones educativas y preventivas necesarias para

  10. Renal Evaluation in Women with Preeclampsia

    Directory of Open Access Journals (Sweden)

    T.A. Facca

    2012-05-01

    Full Text Available Background/Aims: Preeclampsia (PE is a cause of glomerulopathy worldwide. Urinary retinol-binding protein (RBP is a marker of proximal tubular dysfunction, albuminuria is an endothelial injury marker, urine protein:creatinine ratio (PCR may have a predictive value for renal disease later in life, and, recently, podocyturia has been proposed as a sensitive tool in pregnancy, but it needs to be tested. The aim of this study was to evaluate renal involvement in PE and healthy pregnancy. Methods: Case-control study with 39 pregnant women assessed after 20 weeks of gestation (25 in the control group, CG, and 14 in the PE group by performing urinary tests. Results: Mean (±SD age and gestational age of the CG were 26.9 ± 6.4 years and 37.1 ± 5.0 weeks, and of the PE group 26.4 ± 6.9 years and 30.6 ± 5.6 weeks, respectively (p = 0.001. Mean (±SD urinary RBP (p = 0.017, albuminuria (p = 0.002, and urinary albumin concentration (UAC ratio (p = 0.006 of the CG were 0.4 ± 0.7 mg/l, 7.3 ± 6.9 mg/l, and 8.2 ± 6.7 mg/g and of the PE group 2.0 ± 4.4 mg/l, 2,267.4 ± 2,130.8 mg/l (p = 0.002, and 3,778.9 ± 4,296.6 mg/g (p = 0.006, respectively. Mean (±SD urine PCR in the PE group was 6.7 ± 6.1 g/g (p Conclusions: Urinary RBP, PCR, albuminuria, and UAC ratio were elevated in the PE group in comparison to the CG. Podocyturia did not predict PE.

  11. O significado da maternidade na adolescência para jovens gestantes

    Directory of Open Access Journals (Sweden)

    Ana Cristina Garcia Dias

    2015-05-01

    Full Text Available Esse trabalho busca discutir os significados da gestação e maternidade para adolescentes. Para tanto, foram realizadas oito entrevistas com gestantes adolescentes de 15 a 17 anos de idade, que se encontravam no terceiro trimestre de gestação. A entrevista abordou diferentes questões sobre gestação, maternidade e planos de vida das adolescentes. As respostas foram submetidas a uma análise de conteúdo temática. As falas revelaram que a maternidade pode ser almejada, pois a mesma é percebida como uma a possibilidade de construir a própria família e sentirem-se valorizadas socialmente. Por outro lado, o fenômeno da maternidade na adolescência não pode ser compreendido de uma única maneira, pois diversos fatores contribuem para a ocorrência do mesmo. Destaca-se que é necessário ir além de interpretações reducionistas e simplificadas que não consideram questões contextuais e históricas na compreensão desse fenômeno complexo.

  12. Prevalência de HIV em gestantes e transmissão vertical segundo perfil socioeconômico, Vitória, ES Factores asociados a recidiva en hanseníasis en Mato Grosso, Centro-oeste de Brasil HIV prevalence in pregnant women and vertical transmission in according to socioeconomic status, Southeastern Brazil

    Directory of Open Access Journals (Sweden)

    Anne Caroline Barbosa Cerqueira Vieira

    2011-08-01

    Full Text Available OBJETIVO: Descrever a prevalência de infecção por HIV em gestantes e a taxa de transmissão vertical, segundo o perfil socioeconômico dos bairros de residência das mães. MÉTODOS: Estudo ecológico exploratório utilizando a base de dados do Sistema de Informação de Agravos de Notificação de gestantes HIV-positivas e aids em crianças notificadas entre 2000 e 2006 em Vitória, ES. Para análise das informações socioeconômicas foi utilizado o Índice de Qualidade Urbana. A prevalência de HIV em gestantes e a taxa de transmissão vertical foram calculadas. A distribuição espacial dos casos foi realizada no programa Terraview 3.2.0. Para verificar a associação entre a qualidade urbana e a prevalência de HIV em gestantes utilizou-se o modelo de regressão de Poisson. RESULTADOS: Um total de 137 gestantes e 14 crianças infectadas por transmissão vertical foi notificado no período. Sete crianças correspondiam a mães HIV-positivas sem notificação de caso no período analisado. A prevalência de infecção em gestantes no período foi de 0,44% e a taxa de transmissão vertical foi de 9,7%. CONCLUSÕES: A prevalência de infecção por HIV em gestantes e a transmissão vertical associam-se à qualidade urbana do bairro de residência, indicando que os bairros com menor qualidade urbana devem ser priorizados quanto às ações para redução da transmissão vertical.OBJETIVO: Analizar factores asociados a la ocurrencia de recidiva en hanseníasis. MÉTODOS: Estudio retrospectivo caso-control con 159 pacientes mayores de 15 años diagnosticados con hanseníasis en cinco municipios del Estado de Mato Grosso, Centro-oeste de Brasil, cuyas unidades de salud eran consideradas de referencia para el atendimiento. El grupo de casos incluyó 53 individuos con recidiva de 2005 a 2007 y fue comparado con el grupo control (106 con alta por cura en 2005, pareados por sexo y clasificación operacional. Se usaron datos del Sistema de Informaci

  13. Risk factors for new-onset late postpartum preeclampsia in women without a history of preeclampsia.

    Science.gov (United States)

    Bigelow, Catherine A; Pereira, Guilherme A; Warmsley, Amber; Cohen, Jennifer; Getrajdman, Chloe; Moshier, Erin; Paris, Julia; Bianco, Angela; Factor, Stephanie H; Stone, Joanne

    2014-04-01

    Risk factors for the development of new-onset late postpartum preeclampsia (LPP) in women without any history of preeclampsia are not known. Because identification of women who are at risk may lead to an earlier diagnosis of disease and improved maternal outcomes, this study identified risk factors (associated patient characteristics) for new-onset LPP. A case-control study of 34 women with new-onset LPP and 68 women without new-onset LPP after normal delivery, who were matched on date of delivery, was conducted at Mount Sinai Hospital, New York, NY. Data were collected by chart review. Exact conditional logistic regression identified patient characteristics that were associated with new-onset LPP. New-onset LPP was associated with age ≥40 years (adjusted odds ratio, 24.83; 95% confidence interval [CI], 1.43-infinity; P = .03), black race (adjusted odds ratio, 78.35; 95% CI, 7.25-infinity; P infinity; P = .001), final pregnancy body mass index of ≥30 kg/m(2) (adjusted odds ratio, 13.38; 95% CI, 1.87-infinity; P = .01), and gestational diabetes mellitus (adjusted odds ratio, 72.91; 95% CI, 5.52-infinity; P < .001). As predictive tests for new-onset LPP, the sensitivity and specificity of having ≥1 of these characteristics was 100% and 59%, respectively, and the sensitivity and specificity of having ≥2 was 56% and 93%, respectively. Older age, black race, Latino ethnicity, obesity, and a pregnancy complicated by gestational diabetes mellitus all are associated positively with the development of new-onset LPP. Closer observation may be warranted in these populations. Copyright © 2014 Mosby, Inc. All rights reserved.

  14. Endothelial progenitor cell subsets and preeclampsia: Findings and controversies

    Directory of Open Access Journals (Sweden)

    Armin Attar

    2017-10-01

    Full Text Available Vascular remodeling is an essential component of gestation. Endothelial progenitor cells (EPCs play an important role in the regulation of vascular homeostasis. The results of studies measuring the number of EPCs in normal pregnancies and in preeclampsia have been highly controversial or even contradictory because of some variations in technical issues and different methodologies enumerating three distinct subsets of EPCs: circulating angiogenic cells (CAC, colony forming unit endothelial cells (CFU-ECs, and endothelial colony-forming cells (ECFCs. In general, most studies have shown an increase in the number of CACs in the maternal circulation with a progression in the gestational age in normal pregnancies, while functional capacities measured by CFU-ECs and ECFCs remain intact. In the case of preeclampsia, mobilization of CACs and ECFCs occurs in the peripheral blood of pregnant women, but the functional capacities shown by culture of the derived colony-forming assays (CFU-EC and ECFC assays are altered. Furthermore, the number of all EPC subsets will be reduced in umbilical cord blood in the case of preeclampsia. As EPCs play an important role in the homeostasis of vascular networks, the difference in their frequency and functionality in normal pregnancies and those with preeclampsia can be expected. In this review, there was an attempt to provide a justification for these controversies.

  15. Pre-eclampsia and eclampsia: for the general practitioner ...

    African Journals Online (AJOL)

    Pre-eclampsia and eclampsia: for the general practitioner. LAR Mtimavalye. Abstract. No Abstract. Full Text: EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT · AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's ...

  16. The Functions of Microparticles in Pre-Eclampsia

    NARCIS (Netherlands)

    van der Post, Joris A. M.; Lok, Christianne A. R.; Boer, Kees; Sturk, Auguste; Sargent, Ian L.; Nieuwland, Rienk

    2011-01-01

    Pre-eclampsia (P-EC), a heterogenic multisystem disorder characterized by hypertension and proteinuria, usually develops in the second half of pregnancy. The incidence is 2 to 5%, and P-EC is therefore a major cause of maternal and perinatal morbidity and mortality. Although the exact etiology is

  17. Placenta-derived exosomes: potential biomarkers of preeclampsia.

    Science.gov (United States)

    Pillay, Preenan; Moodley, Kogi; Moodley, Jagidesa; Mackraj, Irene

    2017-01-01

    Preeclampsia remains a leading cause of maternal and fetal mortality, due to ineffective treatment and diagnostic strategies, compounded by the lack of clarity on the etiology of the disorder. Although several clinical and biological markers of preeclampsia have been evaluated, they have proven to be ineffective in providing a definitive diagnosis during the various stages of the disorder. Exosomes have emerged as ideal biomarkers of pathological states, such as cancer, and have more recently gained interest in pregnancy-related complications, due to their role in cellular communication in normal and complicated pregnancies. This occurs as a result of the specific placenta-derived exosomal molecular cargo, which may be involved in normal pregnancy-associated immunological events, such as the maintenance of maternal-fetal tolerance. This review provides perspectives on placenta-derived exosomes as possible biomarkers for the diagnosis/prognosis of preeclampsia. Using keywords, online databases were searched to identify relevant publications to review the potential use of placenta-derived exosomes as biomarkers of preeclampsia.

  18. Medical record validation of maternally reported history of preeclampsia

    NARCIS (Netherlands)

    M. Coolman (Marianne); C.J.M. de Groot (Christianne); V.W.V. Jaddoe (Vincent); A. Hofman (Albert); H. Raat (Hein); E.A.P. Steegers (Eric)

    2010-01-01

    textabstractObjective: In this study, we assessed the validity of maternally self-reported history of preeclampsia. Study Design and Setting: This study was embedded in the Generation R Study, a population-based prospective cohort study. Data were obtained from prenatal questionnaires and one

  19. Preeclampsia – Will Orphan Drug Status Facilitate Innovative Biological Therapies?

    Science.gov (United States)

    Hahn, Sinuhe

    2015-01-01

    It is generally accepted that the development of novel therapies to treat pregnancy-related disorders, such as preeclampsia, is hampered by the paucity of research funding. Hence, it is with great interest to become aware of at least three novel therapeutic approaches for the treatment of this disorder: exploiting either the anticoagulant activity of antithrombin, the free radical scavenging activity of alpha-1-microglobulin, or the regenerative capacity of placenta-derived mesenchymal stem cells. As these projects are being carried out by small biotech enterprises, the question arises of how they are able to fund such undertakings. A novel strategy adopted by two of these companies is that they successfully petitioned US and EU agencies in order that preeclampsia is accepted in the register of rare or orphan diseases. This provides a number of benefits including market exclusivity, assistance with clinical trials, and dedicated funding schemes. Other strategies to supplement meager research funds, especially to test novel approaches, could be crowdfunding, a venture that relies on intimate interaction with advocacy groups. In other words, preeclampsia meets Facebook. Perhaps similar strategies can be adopted to examine novel therapies targeting either the imbalance in pro- or anti-angiogenic growth factors, complement activation, reduced levels of placenta protein 13, or excessive neutrophil activation evident in preeclampsia. PMID:25767802

  20. Preeclampsia - will orphan drug status facilitate innovative biological therapies?

    Science.gov (United States)

    Hahn, Sinuhe

    2015-01-01

    It is generally accepted that the development of novel therapies to treat pregnancy-related disorders, such as preeclampsia, is hampered by the paucity of research funding. Hence, it is with great interest to become aware of at least three novel therapeutic approaches for the treatment of this disorder: exploiting either the anticoagulant activity of antithrombin, the free radical scavenging activity of alpha-1-microglobulin, or the regenerative capacity of placenta-derived mesenchymal stem cells. As these projects are being carried out by small biotech enterprises, the question arises of how they are able to fund such undertakings. A novel strategy adopted by two of these companies is that they successfully petitioned US and EU agencies in order that preeclampsia is accepted in the register of rare or orphan diseases. This provides a number of benefits including market exclusivity, assistance with clinical trials, and dedicated funding schemes. Other strategies to supplement meager research funds, especially to test novel approaches, could be crowdfunding, a venture that relies on intimate interaction with advocacy groups. In other words, preeclampsia meets Facebook. Perhaps similar strategies can be adopted to examine novel therapies targeting either the imbalance in pro- or anti-angiogenic growth factors, complement activation, reduced levels of placenta protein 13, or excessive neutrophil activation evident in preeclampsia.

  1. Preeclampsia: Pathogenesis, Prevention, and Long-Term Complications.

    Science.gov (United States)

    Jim, Belinda; Karumanchi, S Ananth

    2017-07-01

    Preeclampsia continues to afflict 5% to 8% of all pregnancies throughout the world and is associated with significant morbidity and mortality to the mother and the fetus. Although the pathogenesis of the disorder has not yet been fully elucidated, current evidence suggests that imbalance in angiogenic factors is responsible for the clinical manifestations of the disorder, and may explain why certain populations are risk. In this review, we begin by demonstrating the roles that angiogenic factors play in pathogenesis of preeclampsia and its complications in the mother and the fetus. We then continue to report on the use of angiogenic markers as biomarkers to predict and risk-stratify disease. Strategies to treat preeclampsia by correcting the angiogenic balance, either by promoting proangiogenic factors or by removing antiangiogenic factors in both animal and human studies, are discussed. We end the review by summarizing status of the current preventive strategies and the long-term cardiovascular outcomes of women afflicted with preeclampsia. Copyright © 2017 Elsevier Inc. All rights reserved.

  2. Can serum free fatty acids assessment predict severe preeclampsia ...

    African Journals Online (AJOL)

    Evaluation of serum fasting FFAs, uric acid, liver transaminases (AST, ALT) during delivery were done. Results: The mean level of FFAs was significantly elevated in preeclampsia cases compared to women with normal blood pressure (2.12 ± 2.64, 0.43± 0.29 respectively, p= 0.003). Also, cases with high FFAs levels had ...

  3. Reduction of the disintegrin and metalloprotease ADAM12 in preeclampsia

    DEFF Research Database (Denmark)

    Laigaard, Jennie; Sørensen, Tina; Placing, Sophie

    2005-01-01

    OBJECTIVES: The secreted form of ADAM12 is a metalloprotease that may be involved in placental and fetal growth. We examined whether the concentration of ADAM12 in first-trimester maternal serum could be used as a marker for preeclampsia. METHODS: We developed a semiautomated, time-resolved, immu......OBJECTIVES: The secreted form of ADAM12 is a metalloprotease that may be involved in placental and fetal growth. We examined whether the concentration of ADAM12 in first-trimester maternal serum could be used as a marker for preeclampsia. METHODS: We developed a semiautomated, time......-resolved, immunofluorometric assay for the quantification of ADAM12 in serum. The assay detected ADAM12 in a range of 78-1248 microg/L. Serum samples derived from women in the first trimester of a normal pregnancy (n = 324) and from women who later developed preeclampsia during pregnancy (n = 160) were obtained from the First...... Trimester Copenhagen Study. ADAM12 levels were assayed in these serum samples. Serum levels of ADAM12 were converted to multiples of the median (MoM) after log-linear regression of concentration versus gestational age. RESULTS: Serum ADAM12 levels in women who developed preeclampsia during pregnancy had...

  4. Mechanisms of Endothelial Dysfunction in Hypertensive Pregnancy and Preeclampsia

    Science.gov (United States)

    Possomato-Vieira, José S.; Khalil, Raouf A.

    2016-01-01

    Preeclampsia is a pregnancy-related disorder characterized by hypertension, and could lead to maternal and fetal morbidity and mortality. Although the causative factors and pathophysiological mechanisms are unclear, endothelial dysfunction is a major hallmark of preeclampsia. Clinical tests and experimental research have suggested that generalized endotheliosis in the systemic, renal, cerebral and hepatic circulation could decrease endothelium-derived vasodilators such as nitric oxide, prostacyclin and hyperpolarization factor and increase vasoconstrictors such as endothelin-1 and thromboxane A2, leading to increased vasoconstriction, hypertension and other manifestation of preeclampsia. In search for the upstream mechanisms that could cause endothelial dysfunction, certain genetic, demographic and environmental risk factors have been suggested to cause abnormal expression of uteroplacental integrins, cytokines and matrix metalloproteinases, leading to decreased maternal tolerance, apoptosis of invasive trophoblast cells, inadequate spiral arteries remodeling, reduced uterine perfusion pressure (RUPP), and placental ischemia/hypoxia. RUPP may cause imbalance between the anti-angiogenic factors soluble fms-like tyrosine kinase-1 and soluble endoglin and the pro-angiogenic factors vascular endothelial growth factor and placental growth factor, or stimulate the release of other circulating bioactive factors such as inflammatory cytokines, hypoxia-inducible factor-1, reactive oxygen species, and angiotensin AT1 receptor agonistic autoantibodies. These circulating factors could then target endothelial cells and cause generalized endothelial dysfunction. Therapeutic options are currently limited, but understanding the factors involved in endothelial dysfunction could help design new approaches for prediction and management of preeclampsia. PMID:27451103

  5. Poor Health-related Quality of Life After Severe Preeclampsia

    NARCIS (Netherlands)

    Hoedjes, Meeke; Berks, Durk; Vogel, Ineke; Franx, Arie; Duvekot, Johannes J.; Steegers, Eric A. P.; Raat, Hein

    Background: Preeclampsia is a major complication of pregnancy associated with increased maternal morbidity and mortality, and adverse birth outcomes. The objective of this study was to describe changes in all domains of health-related quality of life between 6 and 12 weeks postpartum after mild and

  6. Emerging Role of Endothelial and Inflammatory Markers in Preeclampsia

    Directory of Open Access Journals (Sweden)

    Menha Swellam

    2009-01-01

    Full Text Available Objectives: Endothelial disturbance and excess inflammatory response are pathogenic mechanisms in pre-eclampsia (PE. Authors determine the clinical diagnostic role for thrombomodulin (TM, plasminogen activator inhibitor-1 (PAI-1 as endothelial markers and C-reactive protein (CRP, and interlukin-6 (IL-6 as inflammatory markers when tested independently or in combinations.

  7. Preeclampsia – will Orphan Drug Status facilitate innovative biological therapies?

    Directory of Open Access Journals (Sweden)

    Sinuhe eHahn

    2015-02-01

    Full Text Available It is generally accepted that development of novel therapies to treat pregnancy-relates disorders, such as preeclampsia, is hampered to the paucity of research funding. Hence, it is with great interest to become aware of at least three novel therapeutic approaches for the treatment of this disorder, exploiting either the anticoagulant activity of antithrombin, the free radical scavenging activity of alpha-1-microglobulin, or the regenerative capacity of placenta-derived mesenchymal stem cells. As these projects are being carried out by small biotech enterprises, the question arises of how they are able to fund such undertakings. A novel strategy adopted by two of these companies is that they successfully petitioned US and EU agencies in order that preeclampsia be accepted in the register of rare or orphan diseases. This provides a number of benefits including market exclusivity, assistance with clinical trials and dedicated funding schemes. Other strategies to supplement meager research funds, especially to test novel approaches, could be crowdfunding, a venture which relies on intimate interaction with advocacy groups. In other words, preeclampsia meets Facebook. Perhaps similar strategies can be adopted to examine novel therapies targeting either the imbalance in angiogenic growth factors, complement activation, reduced levels of placenta protein 13 or excessive neutrophil activation evident in preeclampsia.

  8. Cognitive function after pre-eclampsia: an explorative study.

    NARCIS (Netherlands)

    Baecke, M.; Spaanderman, M.E.A.; Werf, S.P. van der

    2009-01-01

    BACKGROUND: Pre-eclampsia and eclampsia relate to cerebral damage. Memory and concentration problems are frequently reported after these pregnancy-related vascular complications. We tested the hypothesis that in formerly pre-eclamptic women cognitive functioning is impaired as compared with healthy

  9. Implication of Tumor Necrosis Factor - Alpha in Preeclampsia

    Directory of Open Access Journals (Sweden)

    Dan MIHU

    2008-12-01

    Full Text Available Introduction: Preeclampsia is an exacerbation of a generalized inflammatory response, physiologically present in the third trimester of pregnancy.Aim: The aim of the study consists in the evaluation of proinflammatory cytokine TNF-α in the context of preeclampsia. Material and Method: A transversal study was performed in three groups of patients: non-pregnant patients, patients with normal pregnancies in the third trimester, patients with preeclampsia. Serum TNF-α levels were determined using the immunometric sandwich EIA method.Results: The results obtained confirm a significant increase (p<0.01 in circulating TNF-α levels in the last trimester of pregnancy, compared to the non-pregnant status. Significantly increased serum TNF-α concentrations (p<0.001 were also found in pregnant patients with preeclampsia, compared to normotensive pregnant women. Conclusion: This proinflammatory cytokine can be a potential marker of the severity of the preeclamptic syndrome, without being an indicator of the fetal status at birth.

  10. Altered monocyte function in experimental preeclampsia in the rat

    NARCIS (Netherlands)

    Faas, Marijke M.; Broekema, Martine; Moes, Henk; van der Schaaf, Gerda; Heineman, Maas Jan; de Vos, Paul

    2004-01-01

    OBJECTIVES: In the present study, we evaluated functional activity of monocytes in experimental preeclampsia induced by low-dose endotoxin infusion. STUDY DESIGN: Pregnant (n = 12) and cyclic rats (n = 12) were equipped with a permanent jugular vein cannula and infused with either low-dose endotoxin

  11. ELABELA deficiency promotes preeclampsia and cardiovascular malformations in mice

    NARCIS (Netherlands)

    Ho, Lena; van Dijk, Marie; Chye, Sam Tan Jian; Messerschmidt, Daniel M.; Chng, Serene C.; Ong, Sheena; Yi, Ling Ka; Boussata, Souad; Goh, Grace Hui-Yi; Afink, Gijs B.; Lim, Chin Yan; Dunn, N. Ray; Solter, Davor; Knowles, Barbara B.; Reversade, Bruno

    2017-01-01

    Preeclampsia (PE) is a gestational hypertensive syndrome affecting between 5 and 8% of all pregnancies. Although PE is the leading cause of fetal and maternal morbidity and mortality, its molecular etiology is still unclear. Here, we show that ELABELA (ELA), an endogenous ligand of the apelin

  12. Adiponectin, leptin and oxidative stress in preeclampsia in Egyptian ...

    African Journals Online (AJOL)

    Adiponectin and Leptin are closely related adipokines that are associated with the oxidative stresses and endothelial dysfunction and proposed to participate in preeclampsia (PE) pathogenesis. This study is to determine changes in serum levels of adiponectin, leptin and oxidative stress in PE women in order to speculate a ...

  13. Pre-eclampsia: a Life-threatening Pregnancy Syndrom

    Czech Academy of Sciences Publication Activity Database

    Brázdová, A.; Keprová, Alena; Zídková, J.; Madar, J.

    2014-01-01

    Roč. 57, č. 5 (2014), s. 701-705 ISSN 1516-8913 Grant - others:GA AV ČR(CZ) IAA600110902 Program:IA Institutional support: RVO:61388963 Keywords : placenta * pre-eclampsia * pregnancy * oxidative stress Subject RIV: CE - Biochemistry Impact factor: 0.546, year: 2014

  14. Genética de la preeclampsia: una aproximación a los estudios de ligamiento genético.

    Directory of Open Access Journals (Sweden)

    Nora Alejandra Zuluaga

    2004-06-01

    Full Text Available La preeclampsia es considerada un problema de salud pública debido a su alta prevalencia. Muchas investigaciones coinciden en que su origen se relaciona con la interacción entre factores genéticos y ambientales. Por esta razón, múltiples estudios han explorado tales factores genéticos tratando de identificar regiones cromosómicas y genes candidatos cuyas variantes se relacionen con una mayor susceptibilidad a la enfermedad. Diversos estudios de asociación han identificado algunos genes de susceptibilidad a la preeclampsia, pero los resultados no se han replicado consistentemente en todas las poblaciones, quizá por su complejidad clínica y genética. El levantamiento de mapas de genes y regiones cromosómicas basado en análisis de ligamiento ha mostrado resultados interesantes con algunos marcadores en los cromosomas 2 y 4. En este sentido, hay muchas expectativas con respecto a los genes localizados en tales regiones candidatas, debido a que la identificación de los factores de riesgo genético podría ayudar al entendimiento de esta condición y en proveer claves para su prevención y tratamiento.

  15. MATERNAL AND FETAL OUTCOME IN PRE-ECLAMPSIA AND ECLAMPSIA

    Directory of Open Access Journals (Sweden)

    Sipra

    2015-11-01

    Full Text Available BACKGROUND Pre-Eclampsia and Eclampsia are the leading causes of maternal and perinatal morbidity and mortality worldwide. In developed countries, much lower incidences have been achieved through aggressive screening and management of Pre-Eclampsia. In developing countries like India, there is a wide gap in quality of health care in cities and rural area. The present study was done to evaluate the incidence of hypertensive disorders and maternal and fetal outcome in a tertiary care centre catering to poor people of Bihar, Bengal and neighboring country, Nepal. MATERIALS AND METHODS This is an observational descriptive study. After obtaining institutional ethical committee approval and informed consent from patients, all the patients presenting to our institution for delivery with Pre-Eclampsia and Eclampsia were included in the study. Socio-economic status, frequency of ANC, age, parity and period of gestation were recorded. Investigations included complete blood count, urinary protein, coagulation profile, liver function tests and kidney function tests. Mode of conduct of delivery and maternal and fetal outcome were thoroughly recorded and described. Data was presented in the form of n (%. RESULTS 64.28% cases with Pre-Eclampsia and 95.12% cases with Eclampsia were from low socio-economic status. 95.12% cases with Eclampsia and 67.5% cases with Pre-Eclampsia had no ANC throughout the pregnancy. Most of the patients were in the age group of 20-25 years. 86.11% cases with Eclampsia and 66.68% with Pre-Eclampsia were primigravida. Most of the patients presented with 37 weeks of gestation. 54.76% Pre-Eclampsia cases and 58.94% Eclampsia delivered by L.S.C.S. Pulmonary edema and acute renal failure were the most common complications. Maternal mortality was 25.60% in Eclampsia cases. The most common cause of maternal mortality was pulmonary edema. Incidence of IUD+ stillbirth was 16.66% in Pre-Eclampsia cases and 34.14% in Eclampsia cases. Overall

  16. Ferulic acid alleviates symptoms of preeclampsia in rats by upregulating vascular endothelial growth factor.

    Science.gov (United States)

    Gong, Weiyan; Wan, Jipeng; Yuan, Qing; Man, Quanzhan; Zhang, Xiaojing

    2017-10-01

    Preeclampsia is a complication affecting pregnant women worldwide, which leads to maternal and fetal morbidity and mortality. In this study, we evaluated the efficacy of ferulic acid (FA) on an N ω -nitro-L-arginine methyl ester hydrochloride (L-NAME) induced rat model of preeclampsia. L-NAME was administered to pregnant rats to induce preeclampsia. 48 rats were divided into three experimental groups (n=16 each): control group, preeclampsia group and preeclampsia with FA treatment (preeclampsia+FA). Physiological characteristics such as urine volume, total urine protein and blood pressure were assessed. Expressions levels of urinary nephrin and podocin mRNAs were analyzed by RT-PCR. Levels of renal vascular endothelial growth factor (VEGF), renal soluble fms-like tyrosine kinase-1 (sFlt-1) and serum placenta growth factor (PlGF) were also examined. Urine volume, total urine protein and blood pressure were markedly increased in preeclampsia group rats compared to control (Ppreeclampsia+FA group (Ppreeclampsia+FA group compared to preeclampsia rats (Ppreeclampsia symptoms in a rat preeclampsia model, supporting its potential value in treating preeclampsia. © 2017 John Wiley & Sons Australia, Ltd.

  17. Potential Value of Coagulation Parameters for Suggesting Preeclampsia During the Third Trimester of Pregnancy.

    Science.gov (United States)

    Chen, Ying; Lin, Li

    2017-07-01

    Preeclampsia is a relatively common complication of pregnancy and considered to be associated with different degrees of coagulation dysfunction. This study was developed to evaluate the potential value of coagulation parameters for suggesting preeclampsia during the third trimester of pregnancy. Data from 188 healthy pregnant women, 125 patients with preeclampsia in the third trimester and 120 age-matched nonpregnant women were analyzed. Prothrombin time, prothrombin activity, activated partial thromboplastin time, fibrinogen (Fg), antithrombin, platelet count, mean platelet volume, platelet distribution width and plateletcrit were tested. All parameters, excluding prothrombin time, platelet distribution width and plateletcrit, differed significantly between healthy pregnant women and those with preeclampsia. Platelet count, antithrombin and Fg were significantly lower and mean platelet volume and prothrombin activity were significantly higher in patients with preeclampsia (P preeclampsia was 0.872 for Fg with an optimal cutoff value of ≤2.87g/L (sensitivity = 0.68 and specificity = 0.98). For severe preeclampsia, the area under the curve for Fg reached up to 0.922 with the same optimal cutoff value (sensitivity = 0.84, specificity = 0.98, positive predictive value = 0.96 and negative predictive value = 0.93). Fg is a biomarker suggestive of preeclampsia in the third trimester of pregnancy, and our data provide a potential cutoff value of Fg ≤ 2.87g/L for screening preeclampsia, especially severe preeclampsia. Copyright © 2017 Southern Society for Clinical Investigation. Published by Elsevier Inc. All rights reserved.

  18. Cluster analysis to estimate the risk of preeclampsia in the high-risk Prediction and Prevention of Preeclampsia and Intrauterine Growth Restriction (PREDO) study

    Science.gov (United States)

    Marttinen, Pekka; Gillberg, Jussi; Lokki, A. Inkeri; Majander, Kerttu; Ordén, Maija-Riitta; Taipale, Pekka; Pesonen, Anukatriina; Räikkönen, Katri; Hämäläinen, Esa; Kajantie, Eero; Laivuori, Hannele

    2017-01-01

    Objectives Preeclampsia is divided into early-onset (delivery before 34 weeks of gestation) and late-onset (delivery at or after 34 weeks) subtypes, which may rise from different etiopathogenic backgrounds. Early-onset disease is associated with placental dysfunction. Late-onset disease develops predominantly due to metabolic disturbances, obesity, diabetes, lipid dysfunction, and inflammation, which affect endothelial function. Our aim was to use cluster analysis to investigate clinical factors predicting the onset and severity of preeclampsia in a cohort of women with known clinical risk factors. Methods We recruited 903 pregnant women with risk factors for preeclampsia at gestational weeks 12+0–13+6. Each individual outcome diagnosis was independently verified from medical records. We applied a Bayesian clustering algorithm to classify the study participants to clusters based on their particular risk factor combination. For each cluster, we computed the risk ratio of each disease outcome, relative to the risk in the general population. Results The risk of preeclampsia increased exponentially with respect to the number of risk factors. Our analysis revealed 25 number of clusters. Preeclampsia in a previous pregnancy (n = 138) increased the risk of preeclampsia 8.1 fold (95% confidence interval (CI) 5.7–11.2) compared to a general population of pregnant women. Having a small for gestational age infant (n = 57) in a previous pregnancy increased the risk of early-onset preeclampsia 17.5 fold (95%CI 2.1–60.5). Cluster of those two risk factors together (n = 21) increased the risk of severe preeclampsia to 23.8-fold (95%CI 5.1–60.6), intermediate onset (delivery between 34+0–36+6 weeks of gestation) to 25.1-fold (95%CI 3.1–79.9) and preterm preeclampsia (delivery before 37+0 weeks of gestation) to 16.4-fold (95%CI 2.0–52.4). Body mass index over 30 kg/m2 (n = 228) as a sole risk factor increased the risk of preeclampsia to 2.1-fold (95%CI 1.1–3

  19. Placenta-derived exosomes: potential biomarkers of preeclampsia

    Directory of Open Access Journals (Sweden)

    Pillay P

    2017-10-01

    Full Text Available Preenan Pillay,1,2 Kogi Moodley,1 Jagidesa Moodley,3 Irene Mackraj3 1Discipline of Human Physiology, Nelson R Mandela School of Medicine, School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South Africa; 2Pearson Institute of Higher Education, Midrand, South Africa; 3Women’s Health and HIV Research Group, Nelson R Mandela School of Medicine, School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South Africa Abstract: Preeclampsia remains a leading cause of maternal and fetal mortality, due to ineffective treatment and diagnostic strategies, compounded by the lack of clarity on the etiology of the disorder. Although several clinical and biological markers of preeclampsia have been evaluated, they have proven to be ineffective in providing a definitive diagnosis during the various stages of the disorder. Exosomes have emerged as ideal biomarkers of pathological states, such as cancer, and have more recently gained interest in pregnancy-related complications, due to their role in cellular communication in normal and complicated pregnancies. This occurs as a result of the specific placenta-derived exosomal molecular cargo, which may be involved in normal pregnancy-associated immunological events, such as the maintenance of maternal–fetal tolerance. This review provides perspectives on placenta-derived exosomes as possible biomarkers for the diagnosis/prognosis of preeclampsia. Using keywords, online databases were searched to identify relevant publications to review the potential use of placenta-derived exosomes as biomarkers of preeclampsia. Keywords: placenta-derived exosomes, preeclampsia, biomarkers

  20. The Role of Serum Uric Acid in Preeclampsia

    Directory of Open Access Journals (Sweden)

    Amir Taefi

    2008-09-01

    Full Text Available Objective: The goal of this study was to assess the utility of serum uric acid in preeclampsia diagnosis and its correlation with some maternal and fetal outcomes.Materials and methods: A case-control study was performed on 26 term pregnant women with preeclampsia and 52 normal pregnant women. Serum uric acid, platelet count, hematocrit, gestational age, and birth weight of all patients were measured. Data distribution was assessed with the one sample Kolmogorov-Smirnov test. Mann-Whitney U test was used to assess differences between groups. Correlations between plasma uric acid and other parameters were evaluated with the Spearman’s Rho or Pearson correlation test, where appropriated. Receiver-operating characteristics (ROC curves were used to assess the ability of plasma uric acid to distinguish the preeclampsia from normal subjects. Significance was set at P< 0.05.Results: The mean level of plasma uric acid was 5.8 (+2 mg/dl in cases and 4.9 mg/dl in controls (P=0.04. ROC curve analysis demonstrates the absence of obvious cut off point for plasma uric acid to distinguish preeclampsia. Sensitivity and specificity for uric acid level of 5.5 mg/dl were 61.5% and 78.8%, respectively. There was no significant linear correlation between the plasma uric acid level and other measured parameters in each group.Conclusion: On the basis of our data, the clinical utility of measuring serum uric acid levels in diagnosing preeclampsia is limited.

  1. [Perinatal result with conservative treatment in preeclampsia-eclampsia].

    Science.gov (United States)

    Briones-Garduño, Jesús Carlos; de León-Ponce, Manuel Díaz; González-Vargas, Angel; Briones-Vega, Carlos Gabriel

    2003-01-01

    Conservative treatment in severe preeclampsia has been documented by several authors citing significant improvement in neonatal outcome lacking a significant increase in maternal complications. Our objective was to inform of our preliminary results using protocolized conservative management in women with preeclampsia-eclampsia, favoring better neonate conditions. We included 34 patients with average age of 28.2 years with documented severe preeclampsia-eclampsia complicating a 36-weeks or less pregnancy, admitted in the obstetric intensive care unit (OICU) between October 2001 and February 2002. Patients received protocolized management consisting of intravascular colume expansion, anti-hypertensive control, target organ protection, monitoring, and clinical observation. We considered conservative management as a 24 or more period offered to patients with satisfactory response to medical treatment and no evidence of binomial compromise. Of our group, 85% corresponded to severe preeclampsia, 9% to eclampsia, 3% to imminence of eclampsia, and 3% to HELLP syndrome. Average stay in OICU was 5.5 days with 3.5 days average management before pregnancy was interrupted. These patients presented mean gestational age of 32.8 weeks during which we observed anemia, low platelets, D dimmer increments, MAP average of 112.8, PCOc 18.6, and BI 0.15. We obtained 36 live newborns of whom 12% four died, two were extremely immatures (510 g and 600 g, respectively); one 980-g newborn presented intraventricular hemorrhage, and a 1,450-g newborn had multiple organ failure. Conservative treatment in patients with severe preeclampsia-eclampsia is a feasible alternative in hospitals with an ICU. Conservative management can improve neonatal survival and prognosis in preterm newborns.

  2. Avaliação da saúde bucal das gestantes atendidas no PSF Adirbal Corralo na cidade Passo Fundo-RS

    OpenAIRE

    Carlos Alberto Rech; Patrícia Manfio

    2016-01-01

    O presente trabalho tem por objetivo analisar as condições e percepções de saúde bucal das gestantes que freqüentam o grupo de gestantes do PSF Adirbal Corralo na cidade de Passo Fundo-RS. Trata-se de um estudo quantitativo com abordagem descritiva. Para a coleta de dados foram utilizados questionários acerca da saúde bucal das gestantes, procurando observar quantas vezes e como é feita a escovação, o atendimento odontológico, as orientações odontológicas pré-natais e também exame clínico ver...

  3. Higher decidual EBI3 and HLA-G mRNA expression in preeclampsia : Cause or consequence of preeclampsia

    NARCIS (Netherlands)

    Prins, J. R.; van der Hoorn, M. L. P.; Keijser, R.; Ris-Stalpers, C.; van Beelen, E.; Afink, G. B.; Claas, F. H. J.; van der Post, J. A. M.; Scherjon, S. A.

    The maternal immune system must adapt to tolerate the invasion of the allogeneic feto-placental unit. It is generally accepted that improper adaptation causes pregnancy complications like preeclampsia. The Epstein-Barr virus-induced gene 3 (EBI3) protein is a subunit of immune-modulatory cytokines

  4. Utilidad del tratamiento con hidratación y nifedipino en la amenaza de parto pretérmino

    Directory of Open Access Journals (Sweden)

    Carmen A. Argote Viñals

    2014-08-01

    Full Text Available Se realizó un estudio transversal en gestantes ingresadas con el diagnóstico de amenaza de parto pretérmino, en la sala de cuidados maternos-perinatales del Servicio de Obstetricia del Hospital General Docente “Dr. Ernesto Guevara” de Las Tunas, con el objetivo de determinar la utilidad del tratamiento de la amenaza de parto pretérmino con el empleo de hidratación y nifedipino como terapéutica de elección, en una muestra de 86 gestantes con embarazo viable entre 28 y 34 semanas, que recibieron como tratamiento de ataque la hidratación endovenosa, el reposo en cama y el uso de bloqueadores de los canales del calcio. Se estudiaron como variables: edad materna, edad gestacional al ingreso, paridad, antecedentes personales, tiempo para la desaparición de los síntomas, estadía en la sala de cuidados maternos perinatales y tocolíticos empleados. Predominaron las gestantes de entre 20 y 24 años de edad; las de edad gestacional al ingreso entre 32 a 34 semanas, 37 casos para un 43,1%; las que tenían un parto anterior, 42 (48,8%. Los abortos espontáneos previos (26,7% y el parto prematuro anterior (24,4% resultaron los antecedentes patológicos maternos más significativos. El 53,6% de las gestantes necesitaron tres horas para la desaparición de los síntomas y tres días para estar de alta. El 89,6% pudo llegar al término de su gestación. El empleo de nifedipino e hidratación como tratamiento de elección en la amenaza de parto pretérmino se relacionó con la reducción en el tiempo de alivio de los síntomas, una menor estadía y la prolongación de la gestación, lo que hace a este esquema terapéutico como el más recomendable para la atención de este problema de salud en condiciones similares a la de la investigación

  5. Arterite de Takayasu em Gestante: Relato de Caso / Takayasu Arteritis in Pregnancy: Case Report

    Directory of Open Access Journals (Sweden)

    Patrícia Resende Penido

    2015-12-01

    Full Text Available Introdução: A Arterite de Takayasu (AT consiste em uma vasculopatia de origem indefinida, sendo de caráter crônico, que afeta a aorta e seus ramos principais. Em gestantes é uma condição complexa, em que o tratamento clínico é realizado com restrições. A utilização de corticoides tem sido favorável no controle inflamatório, principalmente naqueles casos em que antes da gravidez se fazia uso de imunossupressores. Casuística: Foi relatado um caso de uma gestante portadora de AT, através da análise de prontuário e de exames complementares, sendo realizado o pré-natal pelas equipes de Obstetrícia e Reumatologia, onde foi realizado tratamento clínico com corticoides, mostrando uma evolução satisfatória, ocorrendo apenas uma hospitalização que foi seguida de uma cesárea na trigésima sexta semana de gravidez, com recém nato saudável de 3.810g. Discussão: A AT pode estar associada a várias etiologias, sendo a gênese pouco conhecida. O diagnóstico na maioria das vezes é demorado, pela dificuldade da suspeita clínica, além de demandar o uso de técnicas de imagem mais sofisticadas. A gestação associada é fenômeno raro, já que as portadoras são orientadas a evitarem a gravidez. O controle clínico permitiu uma gestação sem grandes complicações e serviu como meio para levar a gestação até praticamente o fim do terceiro trimestre. Conclusão: Deve-se ressaltar o papel do acompanhamento clínico, especialmente com esta pan-arterite, mostrando os medicamentos que podem ser utilizados nesse grupo, especialmente quando se usava imunossupressores antes da gravidez. Introduction: Takayasu's arteritis (TA consists of a vascular disease of unknown origin and chronic nature, which affects the aorta and its main branches. In pregnant women it is a complex condition, in which the clinical treatment is performed with restrictions. The use of corticosteroids has been favorable to control inflammation, especially in those

  6. OPIÁCEOS: MECANISMOS DE ACCIÓN, METABOLISMO, Y RELACIÓN CON EL SÍNDROME DE ABSTINENCIA NEONATAL

    OpenAIRE

    Osorio, José Henry

    2009-01-01

    Los niños expuestos a ciertas drogas in utero, pueden resultar físicamente dependientes de estas, sufriendo después del nacimiento síntomas de abstinencia, lo que se denomina síndrome de abstinencia neonatal (NAS). Los niños con NAS presentan disfunción multisistémica, que involucra los sistemas nervioso, gastrointestinal y respiratorio. La presente revisión analiza la literatura disponible, relacionada con el consumo de opiáceos por la madre gestante y el síndrome de abstinencia neonatal. ...

  7. ALTO DÉFICIT DE CONOCIMIENTOS Y PERCEPCIONES ADECUADAS SOBRE ALIMENTACIÓN EN GESTANTES DEL HOSPITAL APOYO IQUITOS, 2012

    OpenAIRE

    Irene Paima; Edwin Zevallos

    2012-01-01

    Los conocimientos y percepciones sobre los alimentos ingeridos en la gestación tienen una vital importancia porque dependiendo de una buena alimentación en esta etapa, periodo en el que se incrementan notablemente las necesidades nutritivas para el beneficio del binomio madre – feto, será de mayor ayuda para prevenir en cada nueva gestación un déficit nutricional. Se realizó un estudio de descriptivo y transversal, la población estuvo conformada por todas las gestantes que acudieron al servic...

  8. Intolerância glicêmica e o prognóstico perinatal em gestantes utilizando anti-retrovirais

    Directory of Open Access Journals (Sweden)

    El Beitune Patrícia

    2003-01-01

    Full Text Available OBJETIVOS: estudar o efeito das drogas anti-retrovirais sobre o metabolismo glicêmico em gestantes portadoras do HIV-1 e a ação dessas medicações sobre o prognóstico perinatal. MÉTODOS: estudo prospectivo realizado em 57 gestantes divididas em três grupos: grupo AZT, utilizando zidovudina (n=20; grupo TT, utilizando zidovudina+lamivudina+nelfinavir (n=25, e grupo controle, gestantes normais (n=12. Obteve-se a área sob a curva (ASC das glicemias após teste oral de tolerância à glicose com 75 g de glicose em quatro oportunidades durante a gravidez (1º=14-20 semanas, 2º=21-26 semanas, 3º=27-32 semanas e 4º=33-38 semanas. O prognóstico perinatal levou em consideração as taxas de prematuridade, restrição de crescimento intra-útero (RCIU, baixo peso ao nascer, mortalidade perinatal e transmissão vertical do HIV-1. Os dados foram analisados utilizando-se os testes não paramétricos do c², de Friedman e de Kruskal-Wallis. RESULTADOS: os valores da mediana da ASC foi de 11.685 mg/dL-2h para o grupo controle, 13.477 mg/dL-2h para o grupo AZT e 13.650 mg/dL-2h para o grupo TT (p=0,049. Não se observou efeito deletério dos anti-retrovirais sobre as taxas de prematuridade, baixo peso ao nascer, RCIU e índices de Apgar. Não houve nenhum caso de transmissão vertical do HIV-1. CONCLUSÕES: verificou-se o desenvolvimento de intolerância glicêmica em gestantes que utilizaram tratamento tríplice, não sendo observado naquelas que utilizaram apenas AZT. Não houve efeitos deletérios dos anti-retrovirais sobre o prognóstico perinatal.

  9. Forma de cuidarse las gestantes adolescentes y adultas de las comunas una y cinco en Santa Marta

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    Mirith Vásquez Munive

    2013-10-01

    Full Text Available ResumenEl cuidado es una experiencia humana holística, que permite conservar la vida y las condiciones de salubridad y adaptarse a situaciones cambiantes. La enfermería tiene como eje central la ciencia del cuidado. Por eso es de gran importancia conocer cuáles son las prácticas de cuidado que tienen las gestantes, y si hay diferencias en este cuidado entre las gestantes adolescentes y las adultas. Para responder este interrogante, se realizó un estudio comparativo en la ciudad de Santa Marta donde, a través de un muestreo intencional por conveniencia, se estudiaron 47 gestantes adolescentes y 92 gestantes adultas. Se valoraron las prácticas de cuidado en cuanto a alimentación, estimulación prenatal, ejercicio y descanso, higiene y cuidados personales, sistemas de apoyo y consumo de sustancias no beneficiosas. Se concluyó que en ambos grupos las prácticas son regulares. La adulta estimula mas a su hijo por nacer, tiene mejores prácticas de higiene y sistemas de apoyo y consumen menos sustancia no beneficiosas. La adolescente tiene mejor práctica de ejercicio y descanso y la alimentación es regular en ambos grupos. (Duazary 2009 I; 31-37AbstractThe care is a holistic human experience that allows to conserve the life and the health conditions and to adapt to changing situations. Infirmary has as central axis the science of the care, for that reason it is of great importance to know which they are the practices of care that have the pregnancy, and if there are differences in this care between the teenager pregnancy and the mature pregnancy. To respond this query, was carried out a comparative study in Santa Marta's city, where through an intentional sampling for convenience 47 teenager pregnancy and 92 mature pregnancy. were studied. The practices of care were valued as for feeding, prenatal stimulation, exercise and rest, hygiene and personal cares, support systems and non beneficial substances. You concluded that in both groups the

  10. O consumo alimentar de gestantes adolescentes no Município do Rio de Janeiro

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    Barros Denise Cavalcante de

    2004-01-01

    Full Text Available O crescimento da gravidez na adolescência é visto com preocupação pela área de saúde pública. O consumo de alimentos que atendam a alta demanda de nutrientes durante a gestação tem sido identificado como um componente relevante. O objetivo do estudo foi conhecer o consumo habitual dos alimentos e de energia e nutrientes entre gestantes adolescentes. Foram entrevistadas 1.180 mães adolescentes em maternidades do Município de Rio de Janeiro e aplicado um Questionário de Freqüência de Consumo Alimentar semiquantitativo simplificado. Os alimentos referidos por pelo menos 50% delas foram arroz, açúcar, manteiga, pão, feijão, leite, refrigerante, sucos, legumes e laranja. Observa-se um menor consumo de sucos, legumes e frutas entre as menores de 15 anos. No primeiro quartil de consumo, a ingestão mínima recomendada de energia, ferro, folato, vitamina C e cálcio não foi alcançada. Encontrou-se uma associação inversa entre o número de pessoas no domicílio e o consumo de energia e nutrientes. O relato de informação sobre alimentação no pré-natal e a informação de mudança de alimentação durante a gravidez esteve associado a um melhor consumo de energia e nutrientes. A atenção pré-natal mostrou-se como um cuidado fundamental para melhores resultados na gestação.

  11. Licença-maternidade e estabilidade da gestante para homens

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    Assis Moreira Silva Júnior

    2014-04-01

    Full Text Available RESUMO Neste artigo são tratados casos em que o modelo de proteção exige alterações pontuais em relação aos personagens, garantindo-se o direito à estabilidade-gestante e à licença-maternidade não apenas à mulher, mas também ao homem, em alguns casos excepcionais que abordamos, quais sejam, viúvo cujo falecimento da esposa tenha se dado por complicações decorrentes do parto, genitor solteiro, casal homoafetivo e genitor ou futuro genitor que seja o único provedor da renda familiar. Há necessidade de compatibilização entre as matérias normativas de diferentes disciplinas, com alterações legislativas que aumentem o manto protetor, com especial atenção para a entidade familiar, que goza de especial proteção do Estado. Mas isso não impede o gozo de tais direitos para os casos excepcionais mencionados, tendo em vista a interpretação sistemática do texto constitucional.   ABSTRACT This article deals with cases where the protection model requires specific changes in relation to the characters, ensuring the right to pregnancy stability and maternity leave, not only to women but also to men, in some exceptional cases that we discussed about, as a widower whose wife’s death has been given from complications through childbirth, single parent, homosexual couple and future parent who is the unique provider of the family income. There is need for compatibility between the normative subjects from different disciplines, with legislative changes that increase the protective mantle, with special attention to the family entity, which enjoys special protection by the State. But this does not prevent the enjoyment of such rights to the exceptional cases mentioned, in view of the systematic interpretation of the constitutional text.

  12. Prevalencia y factores asociados a ruptura prematura de membranas en gestantes del Hospital Vicente Corral Moscoso, Cuenca-Ecuador, noviembre 2011-noviembre 2012

    OpenAIRE

    Cuenca Condoy, Elsa María

    2013-01-01

    Objetivo: Determinar la prevalencia de ruptura prematura de membranas y factores asociados en gestantes del Hospital Vicente Corral Moscoso. Cuenca-Ecuador, durante el periodo enero a julio 2012. -Método y técnicas: Estudio transversal de prevalencia, en 657 gestantes que acudieron al Hospital Vicente Corral Moscoso. - Hipótesis: La Ruptura prematura de membranas es más frecuente cuando se asocian factores como antecedente de infección del tracto urinario, bacteriuria, amenaza de parto pretér...

  13. A realização do teste anti-hiv no pré-natal: os significados para a gestante

    OpenAIRE

    Silva, Roberta Maria de Oliveira; Araújo, Carla Luzia França; Paz, Fatima Maria Trigo da

    2008-01-01

    O estudo teve por objetivo conhecer e analisar o significado da realização do teste anti-HIV no pré-natal para as gestantes. Trata-se de uma pesquisa com abordagem qualitativa e foi realizada em um Hospital Escola e em uma Maternidade do município do Rio de Janeiro. Como recurso técnico-metodológico utilizou-se o discurso do sujeito coletivo (DSC). Após a análise dos discursos verificamos que para as gestantes a realização do teste significa a possibilidade de prevenir a transmissão vertical ...

  14. A dimensão da espiritualidade como estratégia de enfrentamento no diagnóstico positivo de HIV/AIDS em gestantes.

    OpenAIRE

    Pereira, Rita de Cássia de Carvalho

    2010-01-01

    Este estudo pretendeu analisar a dimensão da espiritualidade como uma estratégia de enfrentamento utilizada pelas gestantes atendidas no Serviço de Assistência Especializada Materno Infantil - SAE/MI frente ao diagnóstico soropositivo para HIV/AIDS, do Hospital Universitário Lauro Wanderley-HULW de João Pessoa da Universidade Federal da Paraíba. Trata-se de uma pesquisa descritiva e exploratório, do tipo estudo de caso, com amostra de 08 gestantes infectadas que descobriram o d...

  15. Deseos, aptitudes y conocimientos sobre lactancia materna de gestantes en su tercer trimestre Desires, aptitudes and knowledge about breastfeeding in women at their third trimester of pregnancy

    Directory of Open Access Journals (Sweden)

    Remigio Rafael Gorrita Pérez

    2012-06-01

    Full Text Available Introducción: la lactancia materna es la única forma natural de alimentar al bebé, y una forma inigualable de facilitar el alimento ideal para su crecimiento y desarrollo. Métodos: se realizó un estudio descriptivo, transversal, para evaluar deseos, aptitudes y conocimientos sobre lactancia materna en el tercer trimestre de 114 gestantes del Policlínico "Mártires del 9 de Abril", de San José de las Lajas. Entre marzo de 2010 y de 2011 se valoraron sus historias de salud individual y familiar, y se aplicó a tal efecto un cuestionario con 22 preguntas. Resultados: la información se incorporó a una base de datos y se utilizó para el análisis el estadígrafo chi cuadrado, que se consideró significativo con pIntroduction: breastfeeding is the only natural way of feeding the baby and an unparallel form of providing him with the ideal food for adequate growth and development. Methods: a cross-sectional and descriptive study was conducted to evaluate the desires, the aptitudes and the knowledge about breastfeeding of 114 women in their third trimester of pregnancy from "Martires del 9 de Abril" polyclinics in San José de las Lajas. From March 2010 to March 2011, their individual and family health histories were assessed through a 22-interrogation questionnaire. Results: data were introduced in a database and chi square statistic was used for statistical analysis, the level of significance was p< 0,05. All the participants expressed their desire to breastfeed their offspring. Two thirds were considered prepared or well-prepared to do so, with the required knowledge to attain this objective; but just over one fifth did prove that they had it. Most of the future mothers aged 20 to 35 years; the schooling was mostly technician or high school education (60 for 52.6 %; the marital status of 45.6 % was cohabitation, 40.3 % were married and 13.2 % (15 were singles. These are aspects that undoubtedly influence the results. Conclusions: in addition

  16. Massive vulvar edema in a woman with preeclampsia: a case report.

    Science.gov (United States)

    Daponte, Alexandros; Skentou, Hara; Dimopoulos, Konstantinos D; Kallitsaris, Athanasios; Messinis, Ioannis E

    2007-11-01

    Massive vulvar edema in a woman with preeclampsia preceded the development of massive ascites and impending eclampsia. A 17-year-old preeclamptic, primiparous woman was admitted with preeclampsia and massive vulvar edema. Other causes were excluded. The vulvar edema increased as the blood pressure and ascites increased, and a severe headache developed. Cesarean section for increasing preclampsia was performed. In the puerperium, the blood pressure improved and vulvar edema resolved. The clinical picture of the vulvar edema correlated with the severity of the preeclampsia. The presence of vulvar edema in women with preeclampsia should indicate immediate admission to the hospital. These patients must be considered as at high risk, and close monitoring must be instituted. In our case, vulvar edema preceded massive ascites development. We assume a common development mechanism for these signs in preeclampsia, due mainly to increased capillary permeability and hypoalbuminemia. The attending physician must be prepared for immediate delivery and possible preeclampsia complications in these patients.

  17. Maternal and fetal human leukocyte antigen class Ia and II alleles in severe preeclampsia and eclampsia

    DEFF Research Database (Denmark)

    Emmery, J.; Hachmon, R.; Pyo, C. W.

    2016-01-01

    and -DPB1) alleles and the risk of developing severe preeclampsia/eclampsia were investigated in a detailed and large-scale study. In total, 259 women diagnosed with severe preeclampsia or eclampsia and 260 matched control women with no preeclampsia, together with their neonates, were included in the study....... HLA genotyping for mothers and neonates was performed using next-generation sequencing. The HLA-DPB1*04:01:01G allele was significantly more frequent (Pc=0.044) among women diagnosed with severe preeclampsia/eclampsia compared with controls, and the DQA1*01:02:01G allele frequency was significantly...... lower (Pc=0.042) among newborns born by women with severe preeclampsia/eclampsia compared with controls. In mothers with severe preeclampsia/eclampsia, homozygosity was significantly more common compared with controls at the HLA-DPB1 locus (Pc=0.0028). Although the current large study shows some...

  18. Preeclampsia; short and long-term consequences for mother and neonate.

    Science.gov (United States)

    Bokslag, Anouk; van Weissenbruch, Mirjam; Mol, Ben Willem; de Groot, Christianne J M

    2016-11-01

    Preeclampsia is a common pregnancy specific disease, that presents with hypertension and a variety of organ failures, including malfunction of kidneys, liver and lungs. At present, the only definitive treatment of preeclampsia is end the pregnancy and deliver the neonate and placenta. For women with mild preeclampsia in the preterm phase of pregnancy, expectant management is generally indicated to improve fetal maturity, often requiring maternal medical treatment. Last decades, more evidence is available that the underlying mechanism of preeclampsia, endothelial disease, is not limited to pregnancy but increases cardiovascular risk in later life. In this review, we present the most recent insight in preeclampsia with focus on impact on the fetus, short and long-term outcome of offspring's, and long-term outcome of women with a history of preeclampsia. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  19. Public Health Perspectives of Preeclampsia in Developing Countries: Implication for Health System Strengthening

    OpenAIRE

    Kayode O. Osungbade; Olusimbo K. Ige

    2011-01-01

    Objectives. Review of public health perspectives of preeclampsia in developing countries and implications for health system strengthening. Methods. Literature from Pubmed (MEDLINE), AJOL, Google Scholar, and Cochrane database were reviewed. Results. The prevalence of preeclampsia in developing countries ranges from 1.8% to 16.7%. Many challenges exist in the prediction, prevention, and management of preeclampsia. Promising prophylactic measures like low-dose aspirin and calcium supplem...

  20. Preeclampsia-Associated Hormonal Profiles and Reduced Breast Cancer Risk Among Older Mothers

    Science.gov (United States)

    2003-04-01

    Preeclampsia has been linked to reduced breast cancer risk, and this reduction may be especially marked among women who bear their first child later...in life. In this ongoing case-control study, we examine the hormonal profiles of older Colorado mothers with and without a history of preeclampsia in...premenopausal, and are free of serious chronic disease. Cases are 14 Denver area women who experienced preeclampsia in their first pregnancy; controls are 13

  1. Spontaneous Hepatic Rupture Associated with Preeclampsia: Treatment with Hepatic Artery Embolization

    Energy Technology Data Exchange (ETDEWEB)

    Yang, Seung Boo; Goo, Dong Erk; Chang, Yun Woo; Kim, Yong Jae; Hwang, In Cheol; Han, Hyo Sang; Yoon, Jong Hyun; Lee, Tae Il [Soonchunhyang University Hospital, Gumi (Korea, Republic of)

    2010-02-15

    Spontaneous rupture of the liver due to preeclampsia is a rare condition of pregnant women, and it can be very dangerous if not treated. We report here on a case of successfully treating spontaneous liver rupture associated with preeclampsia by performing transcatheter hepatic arterial embolization. A 41-year-old woman with spontaneous rupture of the liver associated with preeclampsia was treated by hepatic arterial embolization

  2. Spontaneous Hepatic Rupture Associated with Preeclampsia: Treatment with Hepatic Artery Embolization

    International Nuclear Information System (INIS)

    Yang, Seung Boo; Goo, Dong Erk; Chang, Yun Woo; Kim, Yong Jae; Hwang, In Cheol; Han, Hyo Sang; Yoon, Jong Hyun; Lee, Tae Il

    2010-01-01

    Spontaneous rupture of the liver due to preeclampsia is a rare condition of pregnant women, and it can be very dangerous if not treated. We report here on a case of successfully treating spontaneous liver rupture associated with preeclampsia by performing transcatheter hepatic arterial embolization. A 41-year-old woman with spontaneous rupture of the liver associated with preeclampsia was treated by hepatic arterial embolization

  3. Is preeclampsia an independent predictor of diastolic dysfunction? A retrospective cohort study.

    Science.gov (United States)

    Guirguis, George F; Aziz, Michael M; Boccia Liang, Claire; Williams, Shauna F; Apuzzio, Joseph J; Bilinski, Robyn; Mornan, Adenieki J D; Shah, Leena P

    2015-10-01

    To determine if preeclampsia is an independent predictor of diastolic dysfunction and what factors among patients with preeclampsia are associated with diastolic dysfunction. This is a retrospective cohort study of patients who delivered between 2008 and 2013 at a single institution who had a maternal echocardiogram during their pregnancy or within 5months of delivery. Patients with structural heart disease, ejection fraction less than 45%, pulmonary embolus, or age over 45years were excluded. Medical records were reviewed for medical and obstetric complications and echocardiogram findings. Demographic characteristics and rate of diastolic dysfunction were compared between patients with preeclampsia and without preeclampsia. Multivariate logistic regression was performed controlling for age, ethnicity, gestational age at delivery, diabetes, preeclampsia, intrauterine growth restriction (IUGR), antihypertensive use and magnesium sulfate administration. Sixty-six patients were identified, of which 39 (59%) had preeclampsia. Past history of preeclampsia, IUGR in the current pregnancy, antihypertensive use and magnesium sulfate use were higher in the preeclampsia group. Fifteen patients (39%) in the preeclampsia group were African-American compared to 2 (3%) in the control group (ppreeclampsia were found to have diastolic dysfunction compared to 3 (11%) controls (OR=6.18, 95% CI 1.59,24.02; p=0.006). Logistic regression analysis did not reveal other independent predictors of diastolic dysfunction. In the patients with preeclampsia, history of preeclampsia with severe features and IUGR were not associated with diastolic dysfunction. Our study supports previous findings that preeclampsia is associated with diastolic dysfunction. Copyright © 2015 International Society for the Study of Hypertension in Pregnancy. Published by Elsevier B.V. All rights reserved.

  4. Impact of Preeclampsia on Clinical and Functional Outcomes in Women With Peripartum Cardiomyopathy.

    Science.gov (United States)

    Lindley, Kathryn J; Conner, Shayna N; Cahill, Alison G; Novak, Eric; Mann, Douglas L

    2017-06-01

    Preeclampsia is a risk factor for the development of peripartum cardiomyopathy (PPCM), but it is unknown whether preeclampsia impacts clinical or left ventricular (LV) functional outcomes. This study sought to assess clinical and functional outcomes in women with PPCM complicated by preeclampsia. This retrospective cohort study included women diagnosed with PPCM delivering at Barnes-Jewish Hospital between 2004 to 2014. The primary outcome was one-year event-free survival rate for the combined end point of death and hospital readmission. The secondary outcome was recovery of LV ejection fraction. Seventeen of 39 women (44%) with PPCM had preeclampsia. The groups had similar mean LV ejection fraction at diagnosis (29.6 with versus 27.3 without preeclampsia; P =0.5). Women with preeclampsia had smaller mean LV end-diastolic diameters (5.2 versus 6.0 cm; P =0.001), greater relative wall thickness (0.41 versus 0.35 mm Hg; P =0.009), and lower incidence of eccentric remodeling (12% versus 48%; P =0.03). Clinical follow-up was available for 32 women; 5 died of cardiovascular complications within 1 year of diagnosis (4/15 with versus 1/17 without preeclampsia; P =0.16). In time to event analysis, patients with preeclampsia had worse event-free survival during 1-year follow-up ( P =0.047). Echocardiographic follow-up was available in 10 survivors with and 16 without preeclampsia. LV ejection fraction recovered in 80% of survivors with versus 25% without preeclampsia ( P =0.014). PPCM with concomitant preeclampsia is associated with increased morbidity and mortality and different patterns of LV remodeling and recovery of LV function when compared with patients with PPCM that is not complicated by preeclampsia. © 2017 American Heart Association, Inc.

  5. An analysis of the differences between early and late preeclampsia with severe hypertension.

    Science.gov (United States)

    Li, X L; Guo, P L; Xue, Y; Gou, W L; Tong, M; Chen, Q

    2016-01-01

    Preeclampsia is clinically divided into early onset and late onset preeclampsia based on the gestational age at delivery. Although the diagnostic criteria are the same in each subgroup of preeclampsia, it has been suggested that the maternal and perinatal mortalities of early onset and late onset preeclampsia are different. However, studies that compare clinical parameters or laboratory biomarkers between early onset and late onset preeclampsia are limited. Data on 177 women with early or late preeclampsia with severe hypertension were collected from a University Teaching Hospital from January 2010 to January 2011 and analysed. Data included all the clinical parameters and laboratory biomarkers of liver and renal function. 63 women and 114 women were diagnosed with early and late preeclampsia with severe hypertension, respectively. There was no difference in the maternal age and the incidence of clinical symptoms including edema, vision disturbance, severe headache and stillbirth between two groups. There was a decrease in alkaline phosphatase levels in early preeclampsia with severe hypertension but other markers of liver function were not altered. However, renal function including blood urea nitrogen, creatinine and uric acid were significantly higher in early preeclampsia with severe hypertension. Umbilical artery systolic velocity/diastolic velocity ratio was significantly higher in early preeclampsia with severe hypertension. Our data demonstrates that the laboratory biomarkers of renal function differ between early and late preeclampsia with severe hypertension. The severity of renal dysfunction correlated with the time of delivery in preeclampsia with severe hypertension. Copyright © 2015 International Society for the Study of Hypertension in Pregnancy. Published by Elsevier B.V. All rights reserved.

  6. Trends in the incidence of pre-eclampsia and eclampsia in Taiwan between 1998 and 2010

    Directory of Open Access Journals (Sweden)

    Te-Fu Chan

    2015-06-01

    Results: The incidence of pre-eclampsia increased significantly (from 0.87% to 1.21%, but the incidence of eclampsia did not change significantly (from 0.04% to 0.05% between 1998 and 2010. The incidence of pre-eclampsia in the 20–24-year age group was 0.60 ± 0.09%. The relative risk of pre-eclampsia in the different age groups was as follows: aged 35-year age groups.

  7. Vitamin E levels in preeclampsia placenta tissue and its correlation with oxidative stress injury and apoptosis

    Directory of Open Access Journals (Sweden)

    Jun Li

    2017-04-01

    Full Text Available Objective: To study the vitamin E levels in preeclampsia placenta tissue and its correlation with oxidative stress injury and apoptosis. Methods: A total of 60 pregnant women with preeclampsia who received treatment and gave birth in our hospital between July 2012 and January 2016 were collected and divided into mild preeclampsia group (n=41 and severe preeclampsia group (n=19 according to the disease severity; 38 normal pregnant women who received pregnancy test and gave birth in our hospital during the same period were selected as healthy control group. The placental tissue samples of three groups of research subjects were retained, high performance liquid chromatograph-mass spectrometry was used to detect VitE levels in tissue grinding fluid, automatic biochemical analyzer was used to detect the levels of oxidative stress injury indexes, and fluorescence quantitative PCR method was used to detect the mRNA expression of apoptosis molecules. Results: VitE, SOD and CAT levels in grinding fluid of severe preeclampsia group were lower than those of mild preeclampsia group and healthy control group while ROS and AOPP levels were higher than those of mild preeclampsia group and healthy control group; Fas, caspase and Apaf-1 mRNA expression were higher than those of mild preeclampsia group and healthy control group while anti-apoptotic molecules Bcl-2, Bcl-xl, Mcl-2 and p57kip2 mRNA expression were lower than those of mild preeclampsia group and healthy control group. Spearman correlation analysis showed that VitE level in the preeclampsia placenta tissue was directly correlated with oxidative stress injury and cell apoptosis. Conclusion: VitE deficiency is the direct factor that results in oxidative stress and cell apoptosis in patients with preeclampsia, and the VitE supplementation in time is expected to become the auxiliary treatment means for patients with preeclampsia.

  8. Vitamina D y riesgo de preeclampsia: revisión sistemática y metaanálisis.

    Science.gov (United States)

    Serrano-Díaz, Norma Cecilia; Gamboa-Delgado, Edna Magaly; Domínguez-Urrego, Clara Lucía; Vesga-Varela, Andrea Liliana; Serrano-Gómez, Sergio Eduardo; Quintero-Lesmes, Doris Cristina

    2018-05-01

    Introducción. Cada vez son más los hallazgos sobre la relación entre las concentraciones de vitamina D en el ser humano y diversas condiciones clínicas. Hay una gran cantidad de estudios que informan sobre dicha asociación, especialmente con complicaciones obstétricas, incluidas la preeclampsia y la diabetes mellitus de la gestación, entre otras, pero sus resultados todavía no son definitivos, por lo que se requieren estudios de intervención de calidad que confirmen la relación de la vitamina D con dichos resultados.Objetivo. Revisar la información plasmada en estudios en torno al papel de la vitamina D materna y el desarrollo de la preeclampsia.Materiales y métodos. La metodología usada siguió las recomendaciones de la guía Cochrane para la elaboración de revisiones sistemáticas y de la guía del grupo Meta-analysis of Observational Studies in Epidemiology (MOOSE) para los metaanálisis. La búsqueda incluyó estudios observacionales y ensayos clínicos controlados.Resultados. Los niveles bajos de vitamina D, medida con el examen de 25-hidroxivitamina D, son comunes en el embarazo. Los resultados de esta revisión sistemática y del metaanálisis sugieren una asociación inversa entre los niveles de vitamina D y el desarrollo de preeclampsia. Hubo heterogeneidad en los estudios en cuanto a su diseño, población y ubicación geográfica, así como a las definiciones de exposición y resultado. Los ensayos clínicos controlados aleatorizados se excluyeron del metaanálisis.Conclusión. Se encontró una asociación inversa que sugiere que, a mayores concentraciones de vitamina D, menor es la probabilidad de desarrollar preclampsia, a pesar de la heterogeneidad de la medida global en este tipo de análisis.

  9. An RGS2 3'UTR polymorphism is associated with preeclampsia in overweight women.

    Science.gov (United States)

    Karppanen, Tiina; Kaartokallio, Tea; Klemetti, Miira M; Heinonen, Seppo; Kajantie, Eero; Kere, Juha; Kivinen, Katja; Pouta, Anneli; Staff, Anne Cathrine; Laivuori, Hannele

    2016-08-24

    Preeclampsia is a common and heterogeneous vascular syndrome of pregnancy. Its genetic risk profile is yet unknown and may vary between individuals and populations. The rs4606 3' UTR polymorphism of the Regulator of G-protein signaling 2 gene (RGS2) in the mother has been implicated in preeclampsia as well as in the development of chronic hypertension after preeclampsia. The RGS2 protein acts as an inhibitor of physiological vasoconstrictive pathways, and a low RGS2 level is associated with hypertension and obesity, two conditions that predispose to preeclampsia. We genotyped the rs4606 polymorphism in 1339 preeclamptic patients and in 697 controls from the Finnish Genetics of Preeclampsia Consortium (FINNPEC) cohort to study the association of the variant with preeclampsia. No association between rs4606 and preeclampsia was detected in the analysis including all women. However, the polymorphism was associated with preeclampsia in a subgroup of overweight women (body mass index ≥ 25 kg/m(2), and preeclampsia particularly in overweight women and contribute to their increased risk for hypertension and other types of cardiovascular disease later in life.

  10. The common variant rs11646213 is associated with preeclampsia in Han Chinese women.

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    Ji-peng Wan

    Full Text Available BACKGROUND: Preeclampsia, characterized by hypertension and proteinuria, is a multifactorial disease caused by complex interactions between environmental and genetic factors. A recent genome-wide association study of blood pressure reported an association between hypertension and rs11646213. This study evaluated the association between preeclampsia and rs11646213. METHODS: A total of 454 cases and 460 controls were recruited to participate in this study. The single nucleotide polymorphism (SNP rs11646213 was genotyped by polymerase chain reaction (PCR and direct sequencing. RESULTS: The allele frequency of rs11646213 was significantly different between the preeclampsia and control groups (P = 0.017, OR = 1.36, 95% CI = 1.06-1.76. Differences were particularly significant in the severe preeclampsia subgroup (P = 0.002, OR = 1.54, 95% CI = 1.17-2.03 and the early-onset preeclampsia subgroup (P = 0.004, OR = 1.57, 95% CI = 1.16-2.13. Genotyping analysis showed that the T allele of rs11646213 could confer a risk for preeclampsia, severe preeclampsia and early-onset preeclampsia. CONCLUSIONS: Rs11646213 upstream of the CDH13 gene is associated with preeclampsia in Han Chinese women.

  11. D2-Thr92Ala, thyroid hormone levels and biochemical hypothyroidism in preeclampsia.

    Science.gov (United States)

    Procopciuc, Lucia Maria; Caracostea, Gabriela; Hazi, Georgeta; Nemeti, Georgiana; Stamatian, Florin

    2017-02-01

    To identify if there is a relationship between the deiodinase D2-Thr92Ala genetic variant, thyroid hormone levels and biochemical hypothyroidism in preeclampsia. We genotyped 125 women with preeclampsia and 131 normal pregnant women using PCR-RFLP. Serum thyroid hormone levels were determined using ELISA. Our study showed higher TSH and FT4 levels and lower FT3 levels in women with preeclampsia compared to normal pregnant women, with statistical significance for women with mild and severe preeclampsia. The risk to develop pregnancy-induced hypertension (PIH), mild or severe preeclampsia was increased in carriers of at least one D2-Ala92 allele. TSH and FT4 levels were significantly higher and FT3 levels were significantly lower in preeclamptic women with severe preeclampsia if they carried the D2-Ala92 allele compared to non-carriers. Pregnant women with PIH and mild preeclampsia, carriers of at least one D2-Ala92 allele, delivered at lower gestational age neonates with a lower birth weight compared to non-carriers, but the results were statistically significant only in severe preeclampsia. The D2-Thr92Ala genetic variant is associated with the severity and the obstetric outcome of preeclampsia, and it also influences thyroid hormone levels. The study demonstrates non-thyroidal biochemical hypothyroidism - as a result of deiodination effects due to D2 genotypes.

  12. Tamizaje y prevención de pre-eclampsia guiado por Doppler de arterias uterinas: revisión sistemática de la literatura

    OpenAIRE

    Sáez O, Nicolás; Carvajal C, Jorge

    2012-01-01

    Antecedentes: La pre-eclampsia (PE) es una enfermedad grave asociada al embarazo con una prevalencia de ~3%. La identificación de las mujeres en riesgo podría mejorar el resultado materno y perinatal. La estimación de riesgo individual de PE permitiría ofrecer un tratamiento preventivo para ésta [ej: aspirina (AAS)]. Se ha descrito el Doppler de arterias uterinas (DAUt) en primer y segundo trimestre como un método de tamizaje de PE. Objetivo: Recopilar la evidencia disponible sobre el uso del...

  13. Action on Pre-eclampsia: Crisis and recovery.

    Science.gov (United States)

    Milne, Fiona

    2011-01-01

    This is a review of the antenatal guidelines developed under the auspices of the charity Action on Preeclampsia since 2001. They are evidence-based and cover the screening and diagnosis of preeclampsia. They include a risk assessment early in pregnancy, referral for specialist input, a two tier schedule of assessment based on risk, signs and symptoms, referral for step-up care and confirmation of diagnosis, including blood tests. They describe methods for improving reliability of proteinuria testing, and reducing errors in the measurement of blood pressure. Management flowcharts are provided. Copyright © 2010 International Society for the Study of Hypertension in Pregnancy. Published by Elsevier B.V. All rights reserved.

  14. Periodontal disease in pregnancy is a risk factor for preeclampsia.

    Science.gov (United States)

    Shetty, Mamatha; Shetty, Prasanna Kumar; Ramesh, Amitha; Thomas, Biju; Prabhu, Sumathi; Rao, Aruna

    2010-05-01

    Many recent studies have evaluated the relation between periodontitis and pregnancy complications. This study aimed to examine the association between preeclampsia and periodontitis in Indian women. A total of 130 pregnant women were enrolled between 26-32 weeks of gestation. Oral health examinations were performed at recruitment and again within 48 hours of delivery to determine the presence and/or progression of periodontitis in all subjects. Pocket depth, clinical attachment loss (CAL), and gingival index were measured in all subjects. There was significant (p periodontitis both at recruitment and after delivery. Multiple logistic regression demonstrated that periodontitis both at enrolment (OR = 5.78, 95% CI 2.41-13.89) as well as within 48 hours of delivery (OR = 20.15, 95% CI 4.55-89.29), may be associated with an increased risk of preeclampsia.

  15. Natural coagulation inhibitors and active protein c resistance in preeclampsia

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    Cengiz Demir

    2010-01-01

    Full Text Available INTRODUCTION: The etiology of preeclampsia is not fully established. A few studies have shown a relationship between natural coagulation inhibitors and preeclampsia. OBJECTIVES: The purpose of this study was to investigate the status of natural coagulation inhibitors and active protein C resistance (APC-R in preeclampsia. PATIENTS AND METHODS: We studied 70 women with preeclampsia recruited consecutively and 70 healthy pregnant and 70 nonpregnant women as controls. Plasma protein C (PC, free protein S (fPS, antithrombin III (ATIII and APC-R were evaluated. RESULTS: ATIII values were found to be significantly lower in preeclamptic patients than in the control groups (p< 0.001. Nevertheless, there was no significant difference between the healthy pregnant and nonpregnant women groups (p=0.141. The fPS values of the preeclamptic and healthy pregnant groups were lower than that of the nonpregnant group (p< 0.001, and the fPS value of the preeclamptic pregnant women was lower than that of healthy pregnant women (p<0.001. The PC value of the preeclamptic pregnant women was lower than that of the control groups (p< 0.001. The PC value of the healthy pregnant women was lower than that of the nonpregnant women (p< 0.001. The mean APC activity values were lower in the preeclamptic patients than that of the control groups (p< 0.001, p< 0.001. The APC-R positivity rates of the preeclamptic groups were higher than that of the control groups (p<0.001. CONCLUSIONS: This study demonstrated that ATIII, fPS, PC values and APC resistance were lower and APC-R positivity was higher in preeclamptic women than in normal pregnant and nonpregnant women.

  16. Prevention of Preeclampsia: Is it Still a Disappointment?

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    Abeer Eddib

    2009-01-01

    Full Text Available Preeclampsia is a major cause of maternal mortality worldwide, with many preventive strategies tested. In this review we intend to provide a synthesis of available studies of these strategies that have been tested, including systematic reviews. We will not be performing systematic review of the studies here. Of these strategies tested only low dose acetyl salicylic acid (ASA and calcium can be considered helpful for prevention at this time. A recent meta-analysis showed a benefit of low dose ASA for both high (RR 0.75, 95% CI 0.66 to 0.85 and moderate risk groups (RR 0.86, 95% CI 0.79 to 0.95. Therefore, low dose ASA in high risk groups may be useful, with a possible smaller benefit in moderate to low risk women. Another meta-analysis looking at calcium shows benefit for both high and low risk groups with an overall reduction in the risk of preeclampsia (RR 0.48, 95% CI 0.33 to 0.69. As a result, prenatal supplementation of calcium may be beneficial for the prevention of preeclampsia. However, vitamins C and E, zinc, fish oil, and magnesium supplementation have been discounted as potential preventive strategies. Nitric oxide, folic acid, and antithrombotics have not been well studied and there is insufficient data for reliable conclusions to be made. Areas of ongoing research that appear promising in the prevention of preeclampsia include modifiable metabolic factors, angiogenic proteins, angiotensin receptor antibodies, and syncytiotrophoblast microparticles. Strategies targeting these areas may provide opportunities for therapeutic interventions.

  17. Pitfalls in setting up genetic studies on preeclampsia.

    Science.gov (United States)

    Laivuori, Hannele

    2013-04-01

    This presentation will consider approaches to discover susceptibility genes for a complex genetic disorder such as preeclampsia. The clinical disease presumably results from the additive effects of multiple sequence variants from the mother and the foetus together with environmental factors. Disease heterogeneity and underpowered study designs are likely to be behind non-reproducible results in candidate gene association studies. To avoid spurious findings, sample size and characteristics of the study populations as well as replication studies in an independent study population should be an essential part of a study design. In family-based linkage studies relationship with genotype and phenotype may be modified by a variety of factors. The large number of families needed in discovering genetic variants with modest effect sizes is difficult to attain. Moreover, the identification of underlying mutations has proven difficult. When pooling data or performing meta-analyses from different populations, disease and locus heterogeneity may become a major issue. First genome-wide association studies (GWAS) have identified risk loci for preeclampsia. Adequately powered replication studies are critical in order to replicate the initial GWAS findings. This approach requires rigorous multiple testing correction. The expected effect sizes of individual sequence variants on preeclampsia are small, but this approach is likely to decipher new clues to the pathogenesis. The rare variants, gene-gene and gene-environmental interactions as well as noncoding genetic variations and epigenetics are expected to explain the missing heritability. Next-generation sequencing technologies will make large amount of data on genomes and transcriptomes available. Complexity of the data poses a challenge. Different depths of coverage might be chosen depending on the design of the study, and validation of the results by different methods is mandatory. In order to minimize disease heterogeneity in

  18. Enfermedad periodontal: ¿es factor de riesgo para parto pretérmino, bajo peso al nacer o preeclampsia? Periodontal disease: is it a risk factor for premature labor, low birth weight or preeclampsia?

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    José Luis Castaldi

    2006-04-01

    Full Text Available OBJETIVOS: Evaluar si la enfermedad periodontal (EP constituye un factor de riesgo de parto pretérmino, bajo peso al nacer o preeclampsia y si hay alguna relación entre las formas clínicas de la EP y los resultados obstétricos mencionados. MÉTODOS: Estudio analítico, transversal y prospectivo de todas las mujeres que tuvieron su parto en el Hospital Dr. José Penna, de la ciudad de Bahía Blanca, Argentina, entre el 1.º de febrero y el 18 de julio de 2003 y entre el 1.º de marzo y el 31 de mayo de 2004. A las mujeres que cumplieron los criterios de inclusión (ser mayor de 18 años, tener al menos 18 dientes, no ser diabética y que los hijos hubieran sobrevivido al parto se les practicó un examen odontológico en busca de hemorragia al sondaje, movilidad dentaria o inflamación gingival y se realizaron mediciones clínicas de la pérdida de inserción. Se calcularon las razones de posibilidades (odds ratios, RP con sus intervalos de confianza del 95% (IC95% y se ajustaron los resultados por las variables "ser fumadora" y "tener anemia". RESULTADOS: Se registraron 2 003 nacimientos, correspondientes a 1 982 partos. Se excluyeron 420 (21,2% mujeres por no cumplir los criterios de inclusión o por no poder realizárseles el diagnóstico odontológico previsto. De las 1 562 mujeres evaluadas, 809 (51,8% presentaban alguna de las afecciones buscadas; de ellas, 274 (17,5% padecían EP grave y 535 (34,3% tenían gingivitis. En total, 149 (9,5% partos fueron pretérmino, en 161 (10,3% nacieron niños con bajo peso y en 157 (10,0% se presentaron casos de preeclampsia. No se observó asociación alguna entre la EP y el parto pretérmino (RP = 1,06; IC95%: 0,74 a 1,50, el bajo peso al nacer (RP = 1,05; IC95%: 0,74 a 1,47 y la preeclampsia (RP = 0,99; IC95%: 0,70 a 1,40. El riesgo de dar a luz un niño con bajo peso al nacer en el subgrupo de fumadoras de más de 10 cigarrillos diarios fue mayor en las que tenían enfermedad periodontal grave que

  19. Protective Low-Frequency Variants for Preeclampsia in the Fms Related Tyrosine Kinase 1 Gene in the Finnish Population.

    Science.gov (United States)

    Lokki, A Inkeri; Daly, Emma; Triebwasser, Michael; Kurki, Mitja I; Roberson, Elisha D O; Häppölä, Paavo; Auro, Kirsi; Perola, Markus; Heinonen, Seppo; Kajantie, Eero; Kere, Juha; Kivinen, Katja; Pouta, Anneli; Salmon, Jane E; Meri, Seppo; Daly, Mark; Atkinson, John P; Laivuori, Hannele

    2017-08-01

    Preeclampsia is a common pregnancy-specific vascular disorder characterized by new-onset hypertension and proteinuria during the second half of pregnancy. Predisposition to preeclampsia is in part heritable. It is associated with an increased risk of cardiovascular disease later in life. We have sequenced 124 candidate genes implicated in preeclampsia to pinpoint genetic variants contributing to predisposition to or protection from preeclampsia. First, targeted exomic sequencing was performed in 500 preeclamptic women and 190 controls from the FINNPEC cohort (Finnish Genetics of Preeclampsia Consortium). Then 122 women with a history of preeclampsia and 1905 parous women with no such history from the National FINRISK Study (a large Finnish population survey on risk factors of chronic, noncommunicable diseases) were included in the analyses. We tested 146 rare and low-frequency variants and found an excess (observed 13 versus expected 7.3) nominally associated with preeclampsia ( P preeclampsia. © 2017 American Heart Association, Inc.

  20. Using clinical symptoms to predict adverse maternal and perinatal outcomes in women with preeclampsia: data from the PIERS (Pre-eclampsia Integrated Estimate of RiSk) study.

    Science.gov (United States)

    Yen, Tin-Wing; Payne, Beth; Qu, Ziguang; Hutcheon, Jennifer A; Lee, Tang; Magee, Laura A; Walters, Barry N; von Dadelszen, Peter

    2011-08-01

    Preeclampsia is a leading cause of maternal morbidity. The clinical challenge lies in predicting which women with preeclampsia will suffer adverse outcomes and would benefit from treatment, while minimizing potentially harmful interventions. Our aim was to determine the ability of maternal symptoms (i.e., severe nausea or vomiting, headache, visual disturbance, right upper quadrant pain or epigastric pain, abdominal pain or vaginal bleeding, and chest pain or dyspnea) to predict adverse maternal or perinatal outcomes. We used data from the PIERS (Pre-eclampsia Integrated Estimate of RiSk) study, a multicentre, prospective cohort study designed to investigate the maternal risks associated with preeclampsia. Relative risks and receiver operating characteristic (ROC) curves were assessed for each preeclampsia symptom and outcome pair. Of 2023 women who underwent assessment, 52% experienced at least one preeclampsia symptom, with 5.2% and 5.3% respectively experiencing an adverse maternal or perinatal outcome. No symptom and outcome pair, in either of the maternal or perinatal groups, achieved an area under the ROC curve value > 0.7, which would be necessary to demonstrate a discriminatory predictive value. Maternal symptoms of preeclampsia are not independently valid predictors of maternal adverse outcome. Caution should be used when making clinical decisions on the basis of symptoms alone in the preeclamptic patient.

  1. Ações de terapia ocupacional com adolescentes gestantes na rotina diária / Actions of Occupational Therapy with adolescent pregnancy in daily routine

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    Cinthia Raquel Ferreira Nascimento

    2017-11-01

    Full Text Available Introdução: A gestação na adolescência é considerada um problema de saúde pública. Neste contexto, o terapeuta ocupacional pode desenvolver sua abordagem com foco no desempenho ocupacional desta população, que se depara com um novo papel e na modificação de suas ocupações. Objetivo: Descrever as ações de terapia ocupacional com adolescentes gestantes sobre o desempenho em ocupações na rotina diária. Métodos: Estudo do tipo pesquisa-ação com abordagem qualitativa. Foi desenvolvido no ambulatório da Saúde da Mulher de um Hospital Universitário da cidade do Recife – PE, entre março e julho de 2016, com 10 adolescentes gestantes. Os dados foram obtidos por meio de entrevista semiestruturada, consulta a prontuários e observação participante dos grupos, que gerou registros em diário de campo e gravações. Os princípios éticos da Resolução 466/12 do Conselho Nacional de Saúde, foram respeitados. Resultados: As ações foram iniciadas com o levantamento, junto às gestantes, de dificuldades no desempenho ocupacional, problematização esta que favoreceu as discussões posteriores, em direção à construção compartilhada de estratégias. As ocupações indicadas como problemáticas foram: calçar o sapato, depilar-se, atividade sexual, descanso e sono e mobilidade funcional. A partir daí, o grupo elaborou estratégias para melhorar sua performance nestas atividades, bem como qualidade de vida, respaldadas por orientações da terapeuta ocupacional.  Conclusões: No estudo, foi possível identificar as dificuldades no desempenho ocupacional na rotina diária das gestantes, bem como favorecer a reflexão das mesmas sobre as estratégias de enfrentamento, para contribuir com a redução de agravos à saúde, promoção da autonomia e independência funcional.  Abstract Introduction: Gestation in adolescence is considered a public health problem. In this context, the occupational therapist can develop his

  2. O ser adolescente gestante em transição: um enfoque de cuidar-pesquisar sob a ótica da enfermagem

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    Ivete Palmira Sanson Zagonel

    2002-08-01

    Full Text Available Este trabalho tem como objeto o significado do ex-sistir feminino na cotidianidade diante da transição da adolescência e gestação. Objetiva compreender o sentido de ser adolescente gestante em transição ex-sistindo, como fenômeno situado, diante da simultaneidade dos eventos vitais, expressos pelos discursos e cuidar do ser adolescente gestante ao mesmo tempo em que desvela o sentido que funda a simultaneidade transicional feminina dos eventos vitais. Foram analisados oito discursos, utilizando a entrevista fenomenológica guiada pela questão norteadora "o que é ser adolescente e gestante em transição ex-sistindo, como fenômeno situado diante da simultaneidade dos eventos vitais, enquanto este ser é cuidado". A análise compreensiva dos depoimentos deu-se à luz da hermenêutica heideggeriana. Permitiu desvelar o ser adolescente gestante em transição, enquanto ser de possibilidades, projeta-se enquanto ser exsistindo, mostra-se surpresa, temerosa, fragilizada, vivência a ambiguidade entre o prazer e o sofrimento, a partir das significações atribuídas às vivências.

  3. Maternal periodontal disease and preeclampsia in Jaipur population

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    Girija Jaiman

    2018-01-01

    Full Text Available Background: Preeclampsia is identified as an important cause for mother and newborn mortality. Inspite of extensive research, the exact etiological relations have not been established. Hence, an attempt has been made in this study to evaluate the relationship between the preeclampsia and maternal periodontal disease. Materials and Methods: The case–control study comprised of thirty pregnant women distributed equally in the case (preeclampsia and control (healthy group. Gingival index, plaque index, bleeding on probing, clinical probing depth, and clinical attachment level were measured in both groups. Microbiologic examination for identification of one red complex organism Porphyromonas gingivalis and one orange complex organism Fusobacterium nucleatum were done in plaque and placental blood of cases and controls. The clinical examinations and collection of placental blood were done 24 h before delivery. Results: Periodontal condition in the preeclamptic women was statistically worse compared with the normotensive women. There was no statistically significant association between microorganisms in plaque and placental blood between normotensive control and preeclamptic pregnant women. The preeclamptic women had significantly higher chances of having newborns weighing <2.5 kg than the normotensive women. Conclusion: The preeclamptic women were associated with significantly higher periodontitis and lower fetal birth weight than normotensive women.

  4. Maternal periodontal disease and preeclampsia in Jaipur population.

    Science.gov (United States)

    Jaiman, Girija; Nayak, Prathibha Anand; Sharma, Sanu; Nagpal, Kiran

    2018-01-01

    Preeclampsia is identified as an important cause for mother and newborn mortality. Inspite of extensive research, the exact etiological relations have not been established. Hence, an attempt has been made in this study to evaluate the relationship between the preeclampsia and maternal periodontal disease. The case-control study comprised of thirty pregnant women distributed equally in the case (preeclampsia) and control (healthy) group. Gingival index, plaque index, bleeding on probing, clinical probing depth, and clinical attachment level were measured in both groups. Microbiologic examination for identification of one red complex organism Porphyromonas gingivalis and one orange complex organism Fusobacterium nucleatum were done in plaque and placental blood of cases and controls. The clinical examinations and collection of placental blood were done 24 h before delivery. Periodontal condition in the preeclamptic women was statistically worse compared with the normotensive women. There was no statistically significant association between microorganisms in plaque and placental blood between normotensive control and preeclamptic pregnant women. The preeclamptic women had significantly higher chances of having newborns weighing <2.5 kg than the normotensive women. The preeclamptic women were associated with significantly higher periodontitis and lower fetal birth weight than normotensive women.

  5. 3D power Doppler ultrasound in early diagnosis of preeclampsia.

    Science.gov (United States)

    Neto, R Moreira; Ramos, J G L

    2016-01-01

    Preeclampsia is a known cause of maternal, fetal and neonatal morbidity and mortality. Thus, evaluation of the predicting value of comparing 3D power Doppler indices (3DPD) of uteroplacental circulation (UPC) in the first and second trimester in patients who developed preeclampsia (PE) and those who did not and testing the hypothesis that the parameters of vascularization and placenta flow intensity, as determined by three-dimensional ultrasound (3D), are different in normal pregnancies compared with preeclampsia, could be a suitable screening method. A prospective observational study using 3D power Doppler were performed to evaluate the placental perfusion in 96 pregnant women who came to do the ultrasound routine between 11 and 14 weeks. The placental vascular index (VI), flow index (FI), blood vessels and blood flow index (VFI) by three-dimensional Doppler histogram were calculated. All patients repeated the exam between 16 and 20 weeks. The outcome was scored as normal or preeclamptic. Placental vascular indices including VI, FI and VFI were significantly lower in preeclamptic placentas compared with controls in the study performed in the second trimester (ppower Doppler assessment of placental vascular indices in the second trimester has the potential to detect women at risk for subsequent development of PE. Copyright © 2015 International Society for the Study of Hypertension in Pregnancy. Published by Elsevier B.V. All rights reserved.

  6. Water-Sectoral Disorders in Puerperas with Preeclampsia

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    S. V. Galushka

    2007-01-01

    Full Text Available Objective: to study the profile of water sectors in puerperas with preeclampsia and to determine whether it is expedient to include colloidal solutions into an infusion therapy program for this category of patients.Subjects and methods. Forty-two puerperas with moderate and severe preeclampsia, whose delivery was made by cesarean section, were examined. All the study puerperas were divided into 2 groups: 1 22 puerperas who received heta-hydroethylized starch (HES solutions as part of infusion therapy; 2 20 puerperas who did not.Results. At the beginning of the study, both groups had increased systemic water and higher extracellular and interstitial fluid volumes as compared with the normal values. With infusion therapy, Group 1 exhibited a decrease in systemic water from 123.8% on day 1 of the study to 106.7% by day 5 and reductions in interstitial hyperhydration from 141.5 to 110.1% and in extracellular fluid from 139.7 to 108.6% as compared with Group 2. By the end of the study, significant impairments in the balance of water sectors preserved in Group 2.Conclusion. Inclusion of heta-HES (Stabisole into infusion therapy in patients with preeclampsia on days 1—2 after delivery leads to a rapider normalization of impaired water balance.  

  7. A prospective study of maternal carboxyhemoglobin and preeclampsia risk

    Science.gov (United States)

    Rudra, Carole B.; Williams, Michelle A.; Schiff, Melissa A.; Koenig, Jane Q.; Dills, Russell; Yu, Jianbo

    2009-01-01

    Summary We aimed to measure the relation between early-pregnancy maternal carboxyhemoglobin and subsequent preeclampsia risk. We conducted a nested case-control analysis using data from a western Washington State cohort study (1996–2004). We measured maternal whole blood carboxyhemoglobin in 128 women who developed preeclampsia and 419 normotensive controls (mean gestational age at blood draw, 14.8 weeks). After adjustment for confounders, high (≥1%) versus low (carboxyhemoglobin odds ratios [OR] and 95% confidence intervals [CI] were 4.09 [1.30, 12.9] in parous women, 0.53 [0.23, 1.26] in nulliparous women, and 1.11 [0.55, 2.25] in the overall study population (parity interaction p=0.01). The influence of parity on the association was unexpected. The association between high carboxyhemoglobin and preeclampsia risk in parous women implicates hypoxia at the fetal-maternal interface as a pathogenic mechanism. These results also suggest that the etiology of the disease may differ according to parity. PMID:20078828

  8. Aloanticorpo anti-Diego (a em gestante Anti-Diego (a alloantibody in pregnant

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    Célia R. G. Silva

    2004-12-01

    Full Text Available O sistema de grupo sangüíneo Diego é composto principalmente por dois antígenos Diegoª (Diª e Diego b (Di b. A prevalência de Diª na população caucasóide é rara com uma freqüência de aproximadamente de 0,02%, podendo gerar anticorpos que são clinicamente significantes em medicina transfusional e neonatal. O presente estudo relata anti-Diª em gestante caucasóide detectado nos exames realizados no pré-parto por meio do teste indireto de antigamaglobulina humana. Na amostra de sangue de cordão foi realizado o teste de antigamaglobulina direto e o resultado foi negativo, o fenótipo do recém-nascido revelou Di (a - b +; portanto, a criança não desenvolveu doença hemolítica perinatal. O estudo fenotípico realizado em toda a família revelou que a sensibilização materna provavelmente ocorreu na segunda gestação gemelar onde as duas crianças demonstraram a presença de antígeno Diª adquirido por herança paterna.The Diego blood group system is composed of two principal antigens Diegoª (Diª and Diego b (Di b. In the Caucasian population the prevalence of Diª is rare with a frequency of about 0.02% and can lead to the production of antibodies that are important in newborn babies and in transfusional medicine. The present study reports on anti-Diª antibodies in a Caucasian pregnant woman, detected by indirect anti-globulin testing shortly before delivery. The direct anti-globulin test of the newborn's blood cord was negative because its phenotype was Di (a- b+. So the newborn did not develop any hemolytic diseases. A phenotyping study of the whole family was performed which revealed that probably the mother became sensitive during her second pregnancy of twins where the two children presented with the Diª antigen phenotype inherited from the father.

  9. Haptoglobin phenotype, preeclampsia risk and the efficacy of vitamin C and E supplementation to prevent preeclampsia in a racially diverse population.

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    Tracey L Weissgerber

    Full Text Available Haptoglobin's (Hp antioxidant and pro-angiogenic properties differ between the 1-1, 2-1, and 2-2 phenotypes. Hp phenotype affects cardiovascular disease risk and treatment response to antioxidant vitamins in some non-pregnant populations. We previously demonstrated that preeclampsia risk was doubled in white Hp 2-1 women, compared to Hp 1-1 women. Our objectives were to determine whether we could reproduce this finding in a larger cohort, and to determine whether Hp phenotype influences lack of efficacy of antioxidant vitamins in preventing preeclampsia and serious complications of pregnancy-associated hypertension (PAH. This is a secondary analysis of a randomized controlled trial in which 10,154 low-risk women received daily vitamin C and E, or placebo, from 9-16 weeks gestation until delivery. Hp phenotype was determined in the study prediction cohort (n = 2,393 and a case-control cohort (703 cases, 1,406 controls. The primary outcome was severe PAH, or mild or severe PAH with elevated liver enzymes, elevated serum creatinine, thrombocytopenia, eclampsia, fetal growth restriction, medically indicated preterm birth or perinatal death. Preeclampsia was a secondary outcome. Odds ratios were estimated by logistic regression. Sampling weights were used to reduce bias from an overrepresentation of women with preeclampsia or the primary outcome. There was no relationship between Hp phenotype and the primary outcome or preeclampsia in Hispanic, white/other or black women. Vitamin supplementation did not reduce the risk of the primary outcome or preeclampsia in women of any phenotype. Supplementation increased preeclampsia risk (odds ratio 3.30; 95% confidence interval 1.61-6.82, p<0.01 in Hispanic Hp 2-2 women. Hp phenotype does not influence preeclampsia risk, or identify a subset of women who may benefit from vitamin C and E supplementation to prevent preeclampsia.

  10. Prevalência de HIV em gestantes e transmissão vertical segundo perfil socioeconômico, Vitória, ES

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    Anne Caroline Barbosa Cerqueira Vieira

    2011-08-01

    Full Text Available OBJETIVO: Descrever a prevalência de infecção por HIV em gestantes e a taxa de transmissão vertical, segundo o perfil socioeconômico dos bairros de residência das mães. MÉTODOS: Estudo ecológico exploratório utilizando a base de dados do Sistema de Informação de Agravos de Notificação de gestantes HIV-positivas e aids em crianças notificadas entre 2000 e 2006 em Vitória, ES. Para análise das informações socioeconômicas foi utilizado o Índice de Qualidade Urbana. A prevalência de HIV em gestantes e a taxa de transmissão vertical foram calculadas. A distribuição espacial dos casos foi realizada no programa Terraview 3.2.0. Para verificar a associação entre a qualidade urbana e a prevalência de HIV em gestantes utilizou-se o modelo de regressão de Poisson. RESULTADOS: Um total de 137 gestantes e 14 crianças infectadas por transmissão vertical foi notificado no período. Sete crianças correspondiam a mães HIV-positivas sem notificação de caso no período analisado. A prevalência de infecção em gestantes no período foi de 0,44% e a taxa de transmissão vertical foi de 9,7%. CONCLUSÕES: A prevalência de infecção por HIV em gestantes e a transmissão vertical associam-se à qualidade urbana do bairro de residência, indicando que os bairros com menor qualidade urbana devem ser priorizados quanto às ações para redução da transmissão vertical.

  11. Mid-pregnancy circulating immune biomarkers in women with preeclampsia and normotensive controls.

    Science.gov (United States)

    Taylor, Brandie D; Tang, Gong; Ness, Roberta B; Olsen, Jørn; Hougaard, David M; Skogstrand, Kristin; Roberts, James M; Haggerty, Catherine L

    2016-01-01

    To determine if mid-pregnancy circulating immune biomarkers are associated with preeclampsia. Nested case-control study of 410 preeclamptic women and 297 normotensive controls with primiparous singleton pregnancies enrolled in the Danish National Birth Cohort. The mean gestational age in our cohort is 16 weeks (range 9-26). Preeclampsia was defined by blood pressure ⩾140/90 mmHg and proteinuria ⩾3 g/24 h. Serum immune biomarkers included interleukin (IL)-6, IL-6 receptor, IL-4, IL-4 receptor, IL-5, IL-12, IL-2, TNF-α, TNF-β, TNF-receptor, IL-1β, IL-1α, IL-8, IL-10, IFN-γ, IL-18, macrophage migration inhibitory factor, macrophage inflammatory protein, transforming growth factor-beta (TGF-β), and RANTES. Associations with preeclampsia, term preeclampsia and preterm preeclampsia were determined using two logistic regression models; (1) biomarkers were dichotomized by the limit of detection (LOD); (2) on the continuous scale, non-detectable values were imputed by LOD/2 and transformed (base 2). All models were adjusted for body mass index and smoking. IL1β was significantly associated with a decrease in the log odds of preeclampsia (p=0.0065), term preeclampsia (p=0.0230) and preterm preeclampsia (p=0.0068). Results were similar for IL4r and preeclampsia (p=0.0383). In the dichotomized models, detectable TNF-β was significantly associated with preeclampsia (ORadj 1.6, 95% CI 1.1-2.3) and term preeclampsia (OR 1.7, 95% CI 1.1-2.5) but not preterm preeclampsia. Detectable IL6 was significantly with term preeclampsia only (OR 1.5, 95% CI 1.1-2.2). Mid-pregnancy circulating IL1β, IL4r, IL6, and TNFβ were associated with preeclampsia. However, results were not consistent across statistical models. As the relationship is complex, future studies should explore cytokine clusters in preeclampsia risk. Copyright © 2015 International Society for the Study of Hypertension in Pregnancy. Published by Elsevier B.V. All rights reserved.

  12. Información sobre la lactancia materna de las gestantes en su tercer trimestre Information on breast feeding found in pregnant women in their third trimester of gestation

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    Remigio Rafael Gorrita Pérez

    2012-12-01

    Full Text Available Introducción: son universalmente reconocidas las virtudes de la lactancia materna -y es obvio que la mujer está dotada fisiológicamente para el amamantamiento y en un gran número de organizaciones internacionales de salud de diferentes países se han diseñado políticas con el objetivo de promover adecuadamente esta inigualable práctica- pero aún son múltiples los obstáculos que se presentan a su establecimiento exitoso, y los resultados, a largo plazo, no son satisfactorios. Objetivo: evaluar la información que, sobre lactancia materna, poseen las gestantes en el tercer trimestre de su embarazo, que pertenecen al Policlínico "Mártires del 9 de Abril", del municipio San José de las Lajas. Métodos: se realizó un estudio descriptivo, transversal, para conocer el nivel de información sobre lactancia materna, en el tercer trimestre, de 114 gestantes del Policlínico "Mártires del 9 de Abril", de San José de las Lajas. Se valoraron sus historias de salud individual y familiar, y se les aplicó un cuestionario con 22 preguntas que se evaluó cualitativa y cuantitativamente. Resultados: solo la quinta parte de las gestantes poseía la información suficiente sobre lactancia materna, aunque la mayoría había asumido que sí los tenía. Más de la mitad de los 17 aspectos explorados, eran deficientes en más del 50 % de las encuestadas. Los errores más frecuentes fueron: momento de dar agua al niño con lactancia materna exclusiva, cuándo brindar otro alimento, hasta cuándo mantener la lactancia materna, cómo debe ser la dieta de la madre, el alternamiento y el aseo de los pechos, y los impedimentos de la madre para la lactancia. Conclusiones: gran número de gestantes evidencian desconocimientos o actitudes equivocadas de diversa índole en relación con la lactancia materna exclusiva, aunque creen tener dominio del tema. Se deben explorar otros aspectos, además de los conocimientos sobre la lactancia, que, sin duda, atentan

  13. Atrial Natriuretic Peptide (ANP) in early pregnancy is associated with development of preeclampsia in type 1 diabetes

    DEFF Research Database (Denmark)

    Nielsen, Lene Ringholm; Pedersen-Bjergaard, Ulrik; Thorsteinsson, Birger

    2011-01-01

    The vasoactive markers of cardiac overload Atrial Natriuretic Peptide (ANP) and Brain Natriuretic Peptide (BNP) are elevated in preeclampsia. This study documents higher ANP concentrations as early as at 9 weeks in type 1 diabetic women subsequently developing preeclampsia suggesting...... that preeclampsia is associated with cardiovascular changes in early pregnancy....

  14. Morphological Characteristics of Placental Complex in Pregnant Women without Complications in Pregnancy and in the Presence of Severe Preeclampsia

    Science.gov (United States)

    Umbetov, Turakbai Zh.; Berdalinova, Akzhenis K.; Tusupkalieyv, Akylbek B.; Koishybayev, Arip K.; Zharilkasynov, Karaman Ye.

    2016-01-01

    According to the WHO data, preeclampsia develops during late pregnancy in 2-8% of women. Preeclampsia is a major cause of maternal and perinatal morbidity and mortality, therefore, the study of the morphological features of placental complex, taking into account gestational complications in postpartum women with severe preeclampsia is an important…

  15. Maternal endothelial damage as a disorder shared by early preeclampsia, late preeclampsia and intrauterine growth restriction.

    Science.gov (United States)

    Kwiatkowski, Sebastian; Dołegowska, Barbara; Kwiatkowska, Ewa; Rzepka, Rafał; Marczuk, Natalia; Loj, Beata; Torbè, Andrzej

    2017-10-26

    Preeclampsia (PE) and intrauterine growth restriction (IUGR) are separate disease entities that have frequently been reported as sharing the same pathogenesis. In both of them, angiogenesis disorders and generalized endothelial damage with an accompanying inflammation are the dominant symptoms. In this study, we attempted to prove that both these processes demonstrate the same profile in early PE, late PE and IUGR patients, while the only difference is in the degree of exacerbation of the lesions. In 167 patients divided into four groups, three of those with early PE, late PE and IUGR and one control group, fms-like tyrosine kinase-1 (sFlt-1), placental growth factor (PlGF), high sensitive c-reactive protein (hsCRP) and fibronectin were determined. The behavior of these parameters in each of the groups was studied, and correlations between them were sought for. Higher concentrations of sFlt-1, hsCRP and fibronectin and a lower concentration of PlGF were found in the study groups compared to the control group. Significant correlations were observed between the factors concerned. The higher values of disordered angiogenesis markers, endothelial damage markers and inflammatory markers both in the PE and the intrauterine growth restriction (IUGR) groups suggest the existence of shared disorders in the development of these pathologies. The correlations between disordered angiogenesis markers and endothelial damage markers argue in favor of a mutual relationship between these two processes in the development of pathologies evolving as secondary to placental ischemia. The results obtained confirm that the lesion profiles are the same in both PE and IUGR patients, which can be utilized in developing common diagnostic criteria.

  16. Fascitis nodular cervical en paciente gestante: revisión de la literatura y presentación de un caso Cervical nodular fasciitis in a pregnant woman: Review of the literature and presentation of a new case

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    Manuel Acosta-Feria

    2010-09-01

    Full Text Available La fascitis nodular es una lesión benigna rara, de crecimiento rápido, cuya patogenia es aún desconocida. Si bien a nivel de cabeza y cuello aparece en un 20% de los casos, su aparición en pacientes gestantes es extremadamente rara. Presentamos el segundo caso descrito en la literatura en el cual está presente dicha asociación. Mujer de 25 años y gestante de 13 semanas, con una tumoración retroauricular derecha de 3 cm de diámetro, 3 meses de evolución y rápido crecimiento. No presentaba parálisis facial ni dolor en la exploración inicial. Tras la exéresis quirúrgica de la lesión, el diagnóstico anatomopatológico definitivo de ésta, fue de fascitis nodular. Tras 2 años desde la intervención quirúrgica no se ha evidenciado recidiva de la tumoración, llevándose el embarazo a término sin presentar complicaciones ni para la madre ni para el feto.The nodular fasciitis is a rare benign lesion of rapid growth, whose pathogenesis is still unknown. While at the head and neck appeared in 20% of cases, its occurrence in pregnant patients is extremely rare. We report the second case described in the literature in which this association is present. Woman of 25 years and 13 weeks pregnant, who had a right auricular tumour 3 cm in diameter, 3 months of development and rapid growth. No facial paralysis or pain in the initial exploration. After surgical resection of the lesion, the final pathological diagnosis of the same was nodular fasciitis. After two years since the surgery, there was no evidence of recurrence of the tumour, taking ad términun pregnancy without complications or the mother or the fetus.

  17. Comparison of oxidative stress in preeclampsia, normal pregnancy and non-pregnant women

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    A. Ghazavi

    2006-11-01

    Full Text Available Introduction: Preeclampsia is a pregnancy-specific condition characterized by hypertension and proteinuria. Preeclampsia remains a disease of theories as its real etiology has remained elusive. Endothelial cell dysfunction may play a role in the pathobiology of preeclampsia. There is some evidence to suggest that endothelial cell damage result from oxidative stress. The aim of the study was to measure oxidative stress markers in preeclampsia. Material and Methods: Total antioxidant capacity (TAC, lipid peroxidation (LPO and thiol groups was measured in 20 women with preeclampsia, 20 normal pregnant women and 20 nonpregnant women. All three women groups were matched with respect to age, BMI, parity and gestational age. Oxidative stress markers were measured by spectrophotometer methods. Results: Serum concentration of LPO was significantly higher in preeclampsia (17.7 + 3.8 nmol/ml as compared with nonpregnant women (10.4 + 0.48 nmol/ml, p< 0.0001. TAC in preeclamptic women was lower than those in normal pregnant and non-pregnant women, but not statistically significantly. There was no significant difference between the mean concentrations of thiol groups in the women groups. Conclusion: Increased levels of LPO products may cause peroxidative damage of vascular endothelium and result in clinical symptoms of preeclampsia. However, further experimental and clinical studies are necessary to clarify the pathogenesis of preeclampsia.

  18. Biomarker identification and pathway analysis of preeclampsia based on serum metabolomics.

    Science.gov (United States)

    Chen, Tingting; He, Ping; Tan, Yong; Xu, Dongying

    2017-03-25

    Preeclampsia presents serious risk of both maternal and fetal morbidity and mortality. Biomarkers for the detection of preeclampsia are critical for risk assessment and targeted intervention. The goal of this study is to screen potential biomarkers for the diagnosis of preeclampsia and to illuminate the pathogenesis of preeclampsia development based on the differential expression network. Two groups of subjects, including healthy pregnant women, subjects with preeclampsia, were recruited for this study. The metabolic profiles of all of the subjects' serum were obtained by liquid chromatography quadruple time-of-flight mass spectrometry. Correlation between metabolites was analyzed by bioinformatics technique. Results showed that the PC(14:0/00), proline betaine and proline were potential sensitive and specific biomarkers for preeclampsia diagnosis and prognosis. Perturbation of corresponding biological pathways, such as iNOS signaling, nitric oxide signaling in the cardiovascular system, mitochondrial dysfunction were responsible for the pathogenesis of preeclampsia. This study indicated that the metabolic profiling had a good clinical significance in the diagnosis of preeclampsia as well as in the study of its pathogenesis. Copyright © 2017 Elsevier Inc. All rights reserved.

  19. Preeclampsia in autologous and oocyte donation pregnancy: is there a different pathophysiology?

    Science.gov (United States)

    Lashley, Lisa E E L O; Buurma, Aletta; Swings, Godelieve M J S; Eikmans, Michael; Anholts, Jacqueline D H; Bakker, Jaap A; Claas, Frans H J

    2015-06-01

    Oocyte donation (OD) is a specific method of artificial reproductive technology that is accompanied by a higher risk of preeclampsia during pregnancy. The pathophysiological mechanism underlying preeclampsia in OD pregnancies is thought to differ from preeclampsia in autologous pregnancies. As preeclampsia in autologous pregnancies is suggested to be associated with complement activation, we studied C4d deposition, circulating complement components and placental complement regulatory proteins in preeclamptic OD pregnancies. Women with uncomplicated and preeclamptic pregnancies after OD or spontaneous conception were selected. We stained the placentas for C4d, marker for complement activation, measured complement factors C1q, C3 and C4 in maternal sera and quantified the placental mRNA expression of complement regulatory proteins CD46, CD55 and CD59. A significantly (p preeclampsia compared with uncomplicated pregnancies, both OD and autologous. The level of complement factors in serum did not differ between the groups. Children born in the autologous preeclampsia group were significantly lower in birth weight (p preeclampsia pregnancies, there is excessive activation of complement in preeclamptic OD pregnancies. However, in contrast to autologous pregnancies this is not associated with counterbalancing upregulation of complement regulatory proteins. Furthermore, C4d deposition in OD pregnancies is not related to the severity of preeclampsia, suggesting another trigger or regulatory mechanism of placental C4d deposition in preeclamptic OD pregnancies. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  20. Severe preeclampsia and maternal self-report of oral health, hygiene, and dental care.

    Science.gov (United States)

    Boggess, Kim A; Berggren, Erica K; Koskenoja, Viktoria; Urlaub, Diana; Lorenz, Carol

    2013-02-01

    Maternal periodontal disease diagnosed by a detailed oral health examination is associated with preeclampsia. Our objective was to measure the association between maternal self-report of oral symptoms/problems, oral hygiene practices, and/or dental service use before or during pregnancy and severe preeclampsia. A written questionnaire was administered to pregnant females at the time of prenatal ultrasound and outcomes were ascertained by chart abstraction. The χ(2) test compared maternal oral symptoms/problems, hygiene practices, and dental service use between females with severe preeclampsia versus normotensive females. Multivariable logistic regression was used to calculate adjusted odds ratios (aORs) and 95% confidence intervals (CIs) for severe preeclampsia. A total of 48 (10%) of 470 females reported ≥2 oral symptoms/problems in the 6 months before pregnancy and 77 (16%) since pregnancy. Fifty-one (11%) reported previous periodontal treatment. Twenty-eight (6%) of 470 developed severe preeclampsia. Females with a history of periodontal treatment were more likely to develop severe preeclampsia (aOR = 3.71; 95% CI = 1.40 to 9.83) than females without a history of periodontal treatment. Self-reported oral health symptoms/problems, oral hygiene practices, or dental service use before or during pregnancy were not associated with severe preeclampsia when considered in the context of other maternal risk factors. Maternal self-report of previous periodontal treatment before pregnancy is associated with severe preeclampsia.

  1. [Use of sFlt-1/PlGF ratio in preeclampsia : a monocentric retrospective analysis].

    Science.gov (United States)

    Verbeurgt, L; Chantraine, F; De Marchin, J; Minon, J-M; Nisolle, M

    2017-09-01

    Soluble Fms-like tyrosine kinase 1 (sFlt-1) is an anti-angiogenic factor released in higher amounts in preeclampsia and implicated in endothelial dysfunction. sFlt-1/PlGF ratio is used in the prediction of preeclampsia. An sFlt-1/PlGF ratio inferior to 38 predicts the short-term absence of preeclampsia. A ratio ? 85 (early-onset PE) or ? 110 (late-onset of PE) could diagnose preeclampsia. In this study, sFlt-1/PlGF ratio has been measured in 183 patients. Sixty-seven preeclampsia have been diagnosed preeclamptic at delivery. The median sFlt-1/PlGF ratio was 100.3. The median ratio among women with preeclampsia (N=67) versus no preeclampsia (N=116) was 212.7 versus 35.4. In accordance with this analysis, an sFlt-1/PlGF ratio ? 38 has a sensibility of 95,5 % and a specificity of 73.3 %. The positive predictive value and the negative predictive value were 67.4 % and 96.6 %, respectively. These results suggest that sFlt-1/PlGF ratio is helpful in the diagnosis of preeclampsia.

  2. Soluble Endoglin as a new marker for prediction of pre-eclampsia in early pregnancy

    Directory of Open Access Journals (Sweden)

    Khaled Gaber

    2010-01-01

    Conclusion: Pregnant women who are at risk of developing pre-eclampsia can be offered measuring these markers as a screening method to point out those who are more likely to develop pre-eclampsia and warrant close observation and intervention.

  3. High-Density Lipoprotein Cholosterol May Discriminate Mild and Severe Preeclampsia

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    Esra Can

    2011-08-01

    CONCLUSIONS: Blood HDL cholesterol levels measured at delivery were reduced in patients with preeclampsia, and patients with reduced levels of HDL cholesterol had a substantially higher probability of the disease severity in comparision to those with mild preeclampsia or those controls.

  4. Meta-Analysis of Placental Transcriptome Data Identifies a Novel Molecular Pathway Related to Preeclampsia

    NARCIS (Netherlands)

    van Uitert, Miranda; Moerland, Perry D.; Enquobahrie, Daniel A.; Laivuori, Hannele; van der Post, Joris A. M.; Ris-Stalpers, Carrie; Afink, Gijs B.

    2015-01-01

    Studies using the placental transcriptome to identify key molecules relevant for preeclampsia are hampered by a relatively small sample size. In addition, they use a variety of bioinformatics and statistical methods, making comparison of findings challenging. To generate a more robust preeclampsia

  5. Determinants of future cardiovascular health in women with a history of preeclampsia

    NARCIS (Netherlands)

    Zoet, Gerbrand A.; Koster, Maria P H; Velthuis, Birgitta K.; de Groot, Christianne J M; Maas, Angela H E M; Fauser, Bart C J M; Franx, Arie; van Rijn, Bas B.

    2015-01-01

    Women who develop preeclampsia have an increased risk of cardiovascular disease (CVD) later in life. However, current guidelines on cardiovascular risk assessment and prevention are unclear on how and when to screen these women postpartum, and about the role of a positive history of preeclampsia in

  6. Endothelial Nitric Oxide Synthase Haplotypes Are Associated with Preeclampsia in Maya Mestizo Women

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    Lizbeth Díaz-Olguín

    2011-01-01

    Full Text Available Preeclampsia is a specific disease of pregnancy and believed to have a genetic component. The aim of this study was to investigate if three polymorphisms in eNOS or their haplotypes are associated with preeclampsia in Maya mestizo women.

  7. Increased maternal and fetal cholesterol efflux capacity and placental CYP27A1 expression in preeclampsia.

    Science.gov (United States)

    Mistry, Hiten D; Kurlak, Lesia O; Mansour, Yosef T; Zurkinden, Line; Mohaupt, Markus G; Escher, Geneviève

    2017-06-01

    Preeclampsia is a pregnancy-specific condition that leads to increased cardiovascular risk in later life. A decrease in cholesterol efflux capacity is linked to CVD. We hypothesized that in preeclampsia there would be a disruption of maternal/fetal plasma to efflux cholesterol, as well as differences in the concentrations of both placental sterol 27-hydroxylase (CYP27A1) and apoA1 binding protein (AIBP). Total, HDL-, and ABCA1-mediated cholesterol effluxes were performed with maternal and fetal plasma from women with preeclampsia and normotensive controls (both n = 17). apoA1 and apoE were quantified by chemiluminescence, and 27-hydroxycholesterol (27-OHC) by GC-MS. Immunohistochemistry was used to determine placental expression/localization of CYP27A1, AIBP, apoA1, apoE, and SRB1. Maternal and fetal total and HDL-mediated cholesterol efflux capacities were increased in preeclampsia (by 10-20%), but ABCA1-mediated efflux was decreased (by 20-35%; P preeclampsia. Fetal plasma 27-OHC levels were decreased in preeclamptic samples ( P preeclampsia ( P = 0.04). Placental 27-OHC concentrations were also raised in preeclampsia ( P preeclampsia, to remove cholesterol from cells to limit lipid peroxidation and increase placental angiogenesis. Copyright © 2017 by the American Society for Biochemistry and Molecular Biology, Inc.

  8. Preeclampsia with and without intrauterine growth restriction-Two pathogenetically different entities?

    Science.gov (United States)

    Milosevic-Stevanovic, Jelena; Krstic, Miljan; Radovic-Janosevic, Dragana; Stefanovic, Milan; Antic, Vladimir; Djordjevic, Ivana

    2016-11-01

    The objective of this study is to determine the differences in histopathological features of basal decidua and placenta in cases of preeclampsia with or without fetal intrauterine growth restriction (IUGR). A prospective case-control study included a study group consisting of 30 pregnant women with preeclampsia completed by cesarean section (CS), in 19 of whom preeclampsia was associated with IUGR, and in 11 it was not. The control group consisted of 20 healthy pregnant women delivered by elective CS. Placentas and samples of placental bed obtained during CS were histopathologically (HP) analyzed after hematoxylin-eosin staining and immunohistochemical labeling of Cytokeratin 7 (CK7) trophoblastic cells in decidua. Regarding the HP changes in the spiral arteries in preeclampsia, the most frequent features were inadequate transformation of spiral arteries with poor trophoblastic invasion (70.0%) and fibrinoid necrosis of the media (66.7%), and rarely acute atherosis (33.3%) and thrombosis (30.0%). Villous hypermaturity was more frequently found in placentas of patients with preeclampsia with IUGR (p preeclampsia with and without IUGR regarding some of HP alterations of placental bed. Alterations of the placental bed in terms of decidual vasculopathy are more the characteristics of the preeclampsia itself than IUGR, while changes in placental villi primarily follow the presence of IUGR, which could indicate that preeclampsia with and without IUGR are two pathogenetically different entities.

  9. Increased urinary orosomucoid excretion predicts preeclampsia in pregnant women with pregestational type 1 diabetes

    DEFF Research Database (Denmark)

    Christiansen, MS; Hesse, D; Ekbom, P

    2010-01-01

    We evaluated the urinary orosomucoid excretion (UOE) as a biomarker of preeclampsia and preterm delivery in pregnant women with type 1 diabetes.......We evaluated the urinary orosomucoid excretion (UOE) as a biomarker of preeclampsia and preterm delivery in pregnant women with type 1 diabetes....

  10. Relationship of Liver X Receptors α and Endoglin Levels in Serum and Placenta with Preeclampsia.

    Science.gov (United States)

    Wang, Jing; Dong, Xing; Wu, Hong-Yan; Wu, Nan; Zhang, Xue-Jun; Wang, Xin; Shang, Li-Xin

    2016-01-01

    Liver X receptor alpha (LXRα) and endoglin have been postulated to play roles in trophoblast invasion and lipid metabolic disturbances. However, the relationship between LXRα and endoglin levels in serum and placenta of patients with preeclampsia remains poorly understood. The objective of this study was to identify correlations between LXRα, endoglin and preeclampsia and provide new feasible methods of clinical prediction and treatment for preeclampsia. We enrolled 45 patients with preeclampsia (24 with moderate preeclampsia and 21 with severe preeclampsia) and 15 normal pregnant women (control group) who were admitted to the Department of Obstetrics of the General Hospital of Beijing Command between October 2012 and July 2013 in this study. Serum and placental LXRα and endoglin levels were analyzed by enzyme-linked immunosorbent assay, real-time quantitative PCR, tissue microarray and immunohistochemistry. Serum and placental LXRα and endoglin levels were significantly higher in patients with preeclampsia than those in control group (Ppreeclampsia displayed significantly higher LXRα and endoglin levels than those with moderate preeclampsia (Ppreeclampsia were positively correlated (serum: r = 0.486, Ppreeclampsia pathogenesis and development and could be used as potential predictors for this disorder.

  11. Placental Vesicles Carry Active Endothelial Nitric Oxide Synthase and Their Activity is Reduced in Preeclampsia.

    Science.gov (United States)

    Motta-Mejia, Carolina; Kandzija, Neva; Zhang, Wei; Mhlomi, Vuyane; Cerdeira, Ana Sofia; Burdujan, Alexandra; Tannetta, Dionne; Dragovic, Rebecca; Sargent, Ian L; Redman, Christopher W; Kishore, Uday; Vatish, Manu

    2017-08-01

    Preeclampsia, a multisystem hypertensive disorder of pregnancy, is associated with increased systemic vascular resistance. Placentae from patients with preeclampsia have reduced levels of endothelial nitric oxide synthase (eNOS) and, thus, less nitric oxide (NO). Syncytiotrophoblast extracellular vesicles (STBEV), comprising microvesicles (STBMV) and exosomes, carry signals from the syncytiotrophoblast to the mother. We hypothesized that STBEV-bound eNOS (STBEV-eNOS), capable of producing NO, are released into the maternal circulation. Dual-lobe ex vivo placental perfusion and differential centrifugation was used to isolate STBEV from preeclampsia (n=8) and normal pregnancies (NP; n=11). Plasma samples of gestational age-matched preeclampsia and NP (n=6) were used to isolate circulating STBMV. STBEV expressed placental alkaline phosphatase, confirming placental origin. STBEV coexpressed eNOS, but not inducible nitric oxide synthase, confirmed using Western blot, flow cytometry, and immunodepletion. STBEV-eNOS produced NO, which was significantly inhibited by N   G -nitro-l-arginine methyl ester (eNOS inhibitor; P preeclampsia-perfused placentae had lower levels of STBEV-eNOS (STBMV; P preeclampsia women had lower STBEV-eNOS expression compared with that from NP women ( P preeclampsia placentae, as well as in plasma. The lower STBEV-eNOS NO production seen in preeclampsia may contribute to the decreased NO bioavailability in this disease. © 2017 The Authors.

  12. Intake of Probiotic Food and Risk of Preeclampsia in Primiparous Women

    Science.gov (United States)

    Brantsæter, Anne Lise; Myhre, Ronny; Haugen, Margaretha; Myking, Solveig; Sengpiel, Verena; Magnus, Per; Jacobsson, Bo; Meltzer, Helle Margrete

    2011-01-01

    Probiotics have been suggested to modify placental trophoblast inflammation, systemic inflammation, and blood pressure, all potentially interesting aspects of preeclampsia. The authors examined the association between consumption of milk-based probiotic products in pregnancy and development of preeclampsia and its subtypes. The study was performed in the Norwegian Mother and Child Cohort Study by using a prospective design in 33,399 primiparous women in the years 2002–2008. The intake of milk-based products containing probiotic lactobacilli was estimated from a self-reported food frequency questionnaire. Preeclampsia diagnoses were obtained from the Norwegian Medical Birth Registry. Intake of probiotic milk products was associated with reduced risk of preeclampsia. The association was most prominent in severe preeclampsia (adjusted odds ratio (OR) = 0.79, 95% confidence interval (CI): 0.66, 0.96). With probiotic intakes divided into categories representing no, monthly, weekly, or daily intake, a lower risk for preeclampsia (all subtypes) was observed for daily probiotic intake (OR = 0.80, 95% CI: 0.66, 0.96). Lower risks for severe preeclampsia were observed for weekly (OR = 0.75, 95% CI: 0.57, 0.98) and daily (OR = 0.61, 95% CI: 0.43, 0.89) intakes. These results suggest that regular consumption of milk-based probiotics could be associated with lower risk of preeclampsia in primiparous women. PMID:21821542

  13. History of preeclampsia is not associated with an increased risk of thyroid dysfunction

    NARCIS (Netherlands)

    Dekker, Ruth R.; Jochemsen, B.M.; van Pampus, M.G.; Santema, J.G.; Roozendaal, C.; Groen, H.; Links, T.P.; van Doormaal, J.J.

    Objective. We evaluated the thyroid function in women with a history of preeclampsia and/or HELLP syndrome at least 2 years after delivery. Design. Observational retrospective study. Setting. University Medical Center Groningen, The Netherlands. Population. Women with a history of preeclampsia

  14. Serial assessment of cardiovascular control shows early signs of developing pre-eclampsia

    NARCIS (Netherlands)

    Rang, Sasika; Wolf, H.; van Montfrans, G. A.; Karemaker, J. M.

    2004-01-01

    Purpose To evaluate whether differences in autonomic cardiovascular control between normal pregnant women and women who develop pre-eclampsia later in pregnancy can be detected even before or early in pregnancy. Design We studied 42 women, 21 multigravid with a history of pre-eclampsia and 21

  15. Microparticle subpopulations are increased in preeclampsia: Possible involvement in vascular dysfunction?

    NARCIS (Netherlands)

    VanWijk, Marja J.; Nieuwland, Rienk; Boer, Kees; van der Post, Joris A. M.; VanBavel, Ed; Sturk, Augueste

    2002-01-01

    OBJECTIVE: The purpose of this study was to investigate the cellular origin and numbers of circulating microparticles in normal pregnancy and preeclampsia. STUDY DESIGN: Plasma samples from 10 women with preeclampsia, from 10 normal pregnant women, and from 10 nonpregnant women matched for age and

  16. PREVALENCIA DE TRIPANOSOMIASIS AMERICANA EN MUJERES GESTANTES DE UN ÁREA DE SALUD. VALENCIA, 2005-2007

    Directory of Open Access Journals (Sweden)

    Rafael Manuel Ortí Lucas

    2009-01-01

    Full Text Available Fundamento: La enfermedad de Chagas es una patología emergente en nuestro medio debido principalmente al incremento de las migraciones. La prevalencia y el difícil manejo terapéutico hacen del Chagas un problema de salud pública creciente. Pretendemos analizar la prevalencia y perfil epidemiológico de mujeres gestantes latinoamericanas atendidas en el área de influencia del Hospital Clínico de Valencia (HCUV y estimar el riego de transmisión vertical. Métodos: Se estudió a 383 mujeres gestantes asistidas en el HCUV entre febrero de 2005 y julio de 2007. Utilizamos para el cribado la técnica de inmunoprecipitación ID-PaGIA-DiaMed, confirmada mediante Inmunofluorescencia Indirecta (IFI - Inmunoflour Chagas-Inverness Medical. En hijos de mujeres positivas: Microhematocrito, PCR y detección de anticuerpos IgM por IFI, al nacer, e IgG, a los 6 y 12 meses. Resultados: El 9,7% de las mujeres presentaban anticuerpos específicos del parásito. De ellas el 54,1% eran bolivianas, el 13,5% argentinas y 8,1 % colombianas. 81,1% vivieron en zonas rurales y casas de adobe, el 89,2% tenía antecedentes familiares y el 100% conocían la enfermedad y el vector. La seroconversión en un niño de 8 meses supuso una transmisión vertical del 2,7% y una incidencia en mujeres procedentes de zona endémica del 0,3%. Conclusiones: La prevalencia de enfermedad de Chagas en mujeres gestantes latinoamericanas es elevada y supone un riesgo de transmisión vertical importante que obliga a detectar anticuerpos frente al parásito en los exámenes de salud de este colectivo. En el cribado son factores de riesgo los antecedentes familiares de tripanosomiasis y la residencia previa en hábitat rural.

  17. Baixa autoestima situacional em gestantes: uma análise de acurácia Baja autoestima situacional en gestantes: un análisis de acurácia Situational low self-esteem in pregnant women: an analysis of accuracy

    OpenAIRE

    Joyce Carolle Bezerra Cavalcante; Vanessa Emille Carvalho de Sousa; Marcos Venícios de Oliveira Lopes

    2012-01-01

    Para investigar a acurácia de características definidoras do diagnóstico Baixa autoestima situacional, realizou-se um estudo transversal, com 52 gestantes atendidas num centro de atendimento familiar. Utilizou-se a taxonomia da NANDA-I e a escala de Rosenberg. O diagnóstico esteve presente em 32,7% das gestantes e todas as características apresentaram associação estatística com o diagnóstico, exceto "Relata verbalmente desafio situacional ao seu próprio valor". As características com maior se...

  18. Elucidating the Pathogenesis of Pre-eclampsia Using In Vitro Models of Spiral Uterine Artery Remodelling.

    Science.gov (United States)

    McNally, Ross; Alqudah, Abdelrahim; Obradovic, Danilo; McClements, Lana

    2017-10-23

    The aim of the study is to perform a critical assessment of in vitro models of pre-eclampsia using complementary human and cell line-based studies. Molecular mechanisms involved in spiral uterine artery (SUA) remodelling and trophoblast functionality will also be discussed. A number of proteins and microRNAs have been implicated as key in SUA remodelling, which could be explored as early biomarkers or therapeutic targets for prevention of pre-eclampsia. Various 2D and 3D in vitro models involving trophoblast cells, endothelial cells, immune cells and placental tissue were discussed to elucidate the pathogenesis of pre-eclampsia. Nevertheless, pre-eclampsia is a multifactorial disease, and the mechanisms involved in its pathogenesis are complex and still largely unknown. Further studies are required to provide better understanding of the key processes leading to inappropriate placental development which is the root cause of pre-eclampsia. This new knowledge could identify novel biomarkers and treatment strategies.

  19. The role of nitrates in the prevention of preeclampsia: an update.

    Science.gov (United States)

    Kalidindi, Madhavi; Velauthar, Luxmi; Khan, Khalid; Aquilina, Joseph

    2012-12-01

    Defective nitric oxide synthesis and nitric oxide-mediated vasodilatation is widely documented in the pathophysiology of preeclampsia, a leading cause of maternal and perinatal morbidity and mortality worldwide. Several studies demonstrated the beneficial role of nitric oxide agents, especially glyceryl trinitrate and L-arginine in reducing the blood pressure and improving the uteroplacental blood flow velocities. However, there is insufficient evidence on the efficacy and safety of these agents in the prevention of preeclampsia and its complications, as there are very few randomized controlled trials with small number of women. The aim of this review is to summarize and evaluate the role of nitrates in the prevention of preeclampsia based on the available evidence in the literature till date and suggestions for future research. Supplementation with L-arginine and antioxidant vitamins reduced the incidence of preeclampsia in women at high risk of preeclampsia [P nitrates are needed in high-risk women to validate these findings.

  20. Plasma concentration of atrial natriuretic peptide in normal pregnant women and in pregnant women with preeclampsia

    DEFF Research Database (Denmark)

    Mikkelsen, A L; Schütten, G; Asping, U

    1991-01-01

    Plasma concentration of atrial natriuretic peptide (ANP) was determined in pregnant women with preeclampsia, in normal pregnant and in nonpregnant women by a specific radioimmunoassay. Results did not show important differences between nonpregnant controls and normal pregnant women, but a signifi......Plasma concentration of atrial natriuretic peptide (ANP) was determined in pregnant women with preeclampsia, in normal pregnant and in nonpregnant women by a specific radioimmunoassay. Results did not show important differences between nonpregnant controls and normal pregnant women......, but a significant rise was seen in women with preeclampsia compared to nonpregnant controls. Marked interindividual variation was found in all three groups. The mechanism of ANP release may differ between those women with normal pregnancy and those with preeclampsia. It is unclear whether the increased level of ANP...... in preeclampsia is an effect or a cause of the disease....

  1. Circulatory nucleosome levels are significantly increased in early and late-onset preeclampsia.

    Science.gov (United States)

    Zhong, Xiao Yan; Gebhardt, Stefan; Hillermann, Renate; Tofa, Kashefa Carelse; Holzgreve, Wolfgang; Hahn, Sinuhe

    2005-08-01

    Elevations in circulatory DNA, as measured by real-time PCR, have been observed in pregnancies with manifest preeclampsia. Recent reports have indicated that circulatory nucleosome levels are elevated in the periphery of cancer patients. We have now examined whether circulatory nucleosome levels are similarly elevated in cases with preeclampsia. Maternal plasma samples were prepared from 17 cases with early onset preeclampsia (34 weeks gestation) with 10 matched normotensive controls. Levels of circulatory nucleosomes were quantified by commercial ELISA (enzyme-linked immunosorbant assay). The level of circulatory nucleosomes was significantly elevated in both study preeclampsia groups, compared to the matched normotensive control group (p = 0.000 and p = 0.001, respectively). Our data suggests that preeclampsia is associated with the elevated presence of circulatory nucleosomes, and that this phenomenon occurs in both early- and late-onset forms of the disorder. Copyright 2005 John Wiley & Sons, Ltd.

  2. Proteinuria in preeclampsia: Not essential to diagnosis but related to disease severity and fetal outcomes.

    Science.gov (United States)

    Dong, Xin; Gou, Wenli; Li, Chunfang; Wu, Min; Han, Zhen; Li, Xuelan; Chen, Qi

    2017-04-01

    Preeclampsia is a leading cause of maternal and perinatal morbidity and mortality globally and proteinuria can be one of the cardinal features of this disease. However, studies about the association of the amount of proteinuria and the severity of preeclampsia, and perinatal outcomes are limited. Data on 239 women with preeclampsia were retrospectively collected from a university teaching hospital from September 2011 to June 2013 and analysed. Data included all clinical parameters and proteinuria in a 24h urine collection. In cases of severe preeclampsia, significantly fewer patients had proteinuria levels 0.3g/L, but there was no difference in cases of severe preeclampsia when proteinuria levels were >0.3g/L. Furthermore, when proteinuria levels were >0.3g/L, the frequency of severe preeclampsia in each group was significantly higher than the frequency of mild pre-eclampsia cases. Time of onset was significantly earlier in patients with proteinuria >3g/L in a 24h urine collection, but time between the onset of preeclampsia and delivery was not correlated with the amount of proteinuria. The birth weight was significantly lower in patients with proteinuria >3g/L. The incidence of fetal growth restriction or stillbirth was significantly higher in patients with proteinuria >5g/L. Our data demonstrate that the amount of proteinuria is not associated with the severe of preeclampsia, once proteinuria is detected, but is related to the severity of preeclampsia. The adverse fetal outcomes appear to be the function of prematurity rather than proteinuria itself. Copyright © 2017 International Society for the Study of Hypertension in Pregnancy. Published by Elsevier B.V. All rights reserved.

  3. Perinatal Outcomes in Women with Preeclampsia: Experience of a Tertiary Referral Center

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    Semra Eroglu

    2015-11-01

    Full Text Available Aim: The purpose of this study was to investigate the association between maternal-fetal outcomes and the severity of preeclampsia. Material and Method: A total of 528 singleton pregnancies diagnosed with preeclampsia, severe preeclampsia or HELLP syndrome with pregnancies >24 weeks of gestation were retrospectively evaluated. For each patient, maternal age, gravidity, previous obstetric history, family history, gestational age at the time of hospitalization, systolic and diastolic blood pressures, presence of severe preeclampsia symptoms, laboratory values, dexamethasone use for the treatment of thrombocytopenia, route of delivery, maternal and perinatal outcomes were recorded. Results: Within the study period, the occurences of preeclampsia, HELLP syndrome and severe preeclampsia were 1.4%, 0.12% and 0.57%, respectively. In patients with HELLP syndrome, cesarean delivery rate, blood product transfusion, acute renal failure, liver function tests, D-dimer levels, neonatal respiratory distress syndrome (RDS, necrotizing enterocolitis (NEC, preterm retinopathy, pulmonary hemorrhage and sepsis occurrences, were significantly higher than in patients with mild and severe preeclampsia. On the contrary, platelet counts were significantly lower . In patients with mild preeclampsia, gestational age at the time of delivery, vaginal delivery rate, 1 and 5 minute APGAR score and newborn birthweight were significantly higher when compared to patients with severe preeclampsia or HELLP syndrome. In contrast, systolic and diastolic blood pressures, neonatal intensive care unit admission rate, hospital stay, protein levels in 24 hr urine, and maternal hemoglobin levels were significantly lower in this group. Discussion: In the present study, it was found that HELLP syndrome was more frequently associated with maternal complications and neonatal morbidities. For the prevention of morbidities due to these unpredictable syndromes with unclear etiologies

  4. Human chorionic gonadotropin, angiogenic factors, and preeclampsia risk: a nested case-control study.

    Science.gov (United States)

    Asvold, Bjørn O; Eskild, Anne; Vatten, Lars J

    2014-05-01

    To study whether human chorionic gonadotropin concentrations during pregnancy or combinations of human chorionic gonadotropin and other angiogenic factors, soluble fms-like tyrosine kinase 1 and placental growth factor (PlGF), are associated with preeclampsia risk. Nested case-control study. Population cohort of pregnant women. A total of 121 cases of preterm (cases of term preeclampsia (≥37 weeks of gestation) and 356 women without preeclampsia (controls). Women with preeclampsia were identified by linkage to the Medical Birth Registry of Norway. Concentrations of human chorionic gonadotropin, soluble fms-like tyrosine kinase 1 and PlGF were measured in maternal serum samples collected in each trimester of pregnancy. Odds ratios of preterm and term preeclampsia. High human chorionic gonadotropin concentrations (highest quartile) in the first trimester were associated with reduced risk for preterm preeclampsia (OR 0.3, 95% CI 0.1-0.9), compared with low human chorionic gonadotropin (lowest quartile), whereas high human chorionic gonadotropin concentrations in the second trimester were associated with increased risk for preterm preeclampsia (OR 4.0, 95% CI 1.8-8.9). High human chorionic gonadotropin concentrations in the third trimester were associated with increased risk for term preeclampsia (OR 4.8, 95% CI 1.8-13.3). Concentrations of human chorionic gonadotropin above the median value combined with PlGF below the median in the second trimester were associated with very high risk for preterm preeclampsia (OR 36.9, 95% CI 8.2-165.8). The results suggest an important role of human chorionic gonadotropin in the pathophysiological processes that lead to preeclampsia. The combined association of human chorionic gonadotropin and PlGF indicates a possible synergism between underlying biological pathways. © 2014 Nordic Federation of Societies of Obstetrics and Gynecology.

  5. Percepção da gestante sobre a integralidade da atenção pré-natal

    OpenAIRE

    Bezerra, Melina de Paiva

    2008-01-01

    Os principais problemas discutidos sobre a atenção pré-natal na literatura referem-se ao não cumprimento das atividades preconizadas pelo MS por parte dos profissionais durante as consultas pré-natais, ocasionando uma baixa qualidade da atenção pré-natal e a óbitos materno-infantis. A avaliação na percepção da gestante e do pesquisador constitui um método para identificar os conflitos existentes na organização do serviço de saúde e nas práticas profissionais, sendo relevante a decodificação d...

  6. Prevention of Vascular Dysfunction after Preeclampsia: A Potential Long-Term Outcome Measure and an Emerging Goal for Treatment

    Directory of Open Access Journals (Sweden)

    Merzaka Lazdam

    2012-01-01

    Full Text Available Preeclampsia is increasingly being recognised as more than an isolated disease of pregnancy. In particular, preeclampsia has emerged as an independent risk factor for maternal cardiovascular disease and has recently been recognised as a risk factor for cardiovascular disease in children exposed in utero. Preeclampsia and cardiovascular disease may share important pathophysiological and molecular mechanisms and further investigation into these is likely to offer insight into the origins of both conditions. This paper considers the links between cardiovascular disease and preeclampsia and the implication of these findings for refinement of the management of patients whose care is complicated by preeclampsia.

  7. Evaluation of Oxidative Stress and Using a Novel Automated Method For Measurement of Total Antioxidant Status in Preeclampsia

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    Ebru Kale

    2006-04-01

    CONCLUSIONS: Our findings suggest that preeclampsia is related with enhanced lipid peroxidation and decreased total antioxidant response before delivery and these parameters may be related at least partly to the pathogenesis of preeclampsia. Decreased lipid peroxidation and increased total antioxidant response after delivery may suggest recov ery of preeclampsia and using a simple, rapid and reliable automated method f acilitates to ev aluate and follow up of the lev els of oxidativ e stress in preeclampsia and this novel method may be used as a routine test in clinical practice while managing preeclampsia

  8. Atrial Natriuretic Peptide (ANP) in early pregnancy is associated with development of preeclampsia in type 1 diabetes

    DEFF Research Database (Denmark)

    Nielsen, Lene Ringholm; Pedersen-Bjergaard, Ulrik; Thorsteinsson, Birger

    2011-01-01

    The vasoactive markers of cardiac overload Atrial Natriuretic Peptide (ANP) and Brain Natriuretic Peptide (BNP) are elevated in preeclampsia. This study documents higher ANP concentrations as early as at 9 weeks in type 1 diabetic women subsequently developing preeclampsia suggesting that preecla......The vasoactive markers of cardiac overload Atrial Natriuretic Peptide (ANP) and Brain Natriuretic Peptide (BNP) are elevated in preeclampsia. This study documents higher ANP concentrations as early as at 9 weeks in type 1 diabetic women subsequently developing preeclampsia suggesting...... that preeclampsia is associated with cardiovascular changes in early pregnancy....

  9. Enfermedad periodontal: ¿es factor de riesgo para parto pretérmino, bajo peso al nacer o preeclampsia?

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    José Luis Castaldi

    2006-04-01

    Full Text Available OBJETIVOS: Evaluar si la enfermedad periodontal (EP constituye un factor de riesgo de parto pretérmino, bajo peso al nacer o preeclampsia y si hay alguna relación entre las formas clínicas de la EP y los resultados obstétricos mencionados. MÉTODOS: Estudio analítico, transversal y prospectivo de todas las mujeres que tuvieron su parto en el Hospital Dr. José Penna, de la ciudad de Bahía Blanca, Argentina, entre el 1.º de febrero y el 18 de julio de 2003 y entre el 1.º de marzo y el 31 de mayo de 2004. A las mujeres que cumplieron los criterios de inclusión (ser mayor de 18 años, tener al menos 18 dientes, no ser diabética y que los hijos hubieran sobrevivido al parto se les practicó un examen odontológico en busca de hemorragia al sondaje, movilidad dentaria o inflamación gingival y se realizaron mediciones clínicas de la pérdida de inserción. Se calcularon las razones de posibilidades (odds ratios, RP con sus intervalos de confianza del 95% (IC95% y se ajustaron los resultados por las variables "ser fumadora" y "tener anemia". RESULTADOS: Se registraron 2 003 nacimientos, correspondientes a 1 982 partos. Se excluyeron 420 (21,2% mujeres por no cumplir los criterios de inclusión o por no poder realizárseles el diagnóstico odontológico previsto. De las 1 562 mujeres evaluadas, 809 (51,8% presentaban alguna de las afecciones buscadas; de ellas, 274 (17,5% padecían EP grave y 535 (34,3% tenían gingivitis. En total, 149 (9,5% partos fueron pretérmino, en 161 (10,3% nacieron niños con bajo peso y en 157 (10,0% se presentaron casos de preeclampsia. No se observó asociación alguna entre la EP y el parto pretérmino (RP = 1,06; IC95%: 0,74 a 1,50, el bajo peso al nacer (RP = 1,05; IC95%: 0,74 a 1,47 y la preeclampsia (RP = 0,99; IC95%: 0,70 a 1,40. El riesgo de dar a luz un niño con bajo peso al nacer en el subgrupo de fumadoras de más de 10 cigarrillos diarios fue mayor en las que tenían enfermedad periodontal grave que

  10. Anemia e deficiência de ferro em gestantes adolescentes Anemia and iron deficiency in pregnant adolescents

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    Elizabeth FUJIMORI

    2000-12-01

    Full Text Available Por meio de dosagem de ferritina sérica, transferrina sérica, hemoglobina e hematócrito, caracterizou-se o estado nutricional de ferro de 79 gestantes adolescentes de primeira consulta pré-natal (£ 20 semanas de gestação, atendidas na Rede Básica de Saúde de um Município da Grande São Paulo. Todos os valores hematológicos estudados foram menores entre as gestantes do segundo trimestre gestacional em relação às do primeiro, sendo as diferenças estatisticamente significativas (pThe objective of this study was to characterize iron nutritional status of 79 pregnant adolescents, at first prenatal consultation (<= 20 weeks of gestation, in the Primary Health System of a district of Great São Paulo, through the serum ferritin, serum transferrin, hemoglobin and hematocrit determinations. All the hematologic values studied were smaller for the pregnant adolescents in the second gestational trimester than for the ones in the first. Statistically significant differences (p.<.0.05 were found just for hemoglobin. It was verified that 64.3% and 32.1% had, respectively, less than 500.mg and 300.mg of organic iron reservations, and 5.4% presented serious lack of this mineral. By World Health Organization criterion 19.0% of the pregnant women were iron-deficient (Saturation of Transferrin <.16% and 13.9% were anemic (Hemoglobin.<.11 g/dl.

  11. Impacto de um programa de orientação dietética sobre a velocidade de ganho de peso de gestantes atendidas em unidades de saúde Impact of a dietary counseling program on the gain weight speed of pregnant women attended in a primary care service

    Directory of Open Access Journals (Sweden)

    Márcia Regina Vítolo

    2011-01-01

    Full Text Available OBJETIVO: avaliar o impacto das orientações alimentares sobre o controle de ganho de peso entre gestantes atendidas em um serviço público de saúde. MÉTODOS: o estudo foi desenvolvido em uma unidade de saúde de referência localizada na região metropolitana da cidade de Porto Alegre, no Rio Grande do Sul, Brasil. Trezentos e quinze gestantes entre a 10ª e 29ª semana gestacional foram randomizadas entre Grupo Controle e Intervenção. O Grupo Intervenção recebeu orientações alimentares de acordo com o estado nutricional, e as gestantes do Grupo Controle permaneceram no atendimento de rotina. Foram realizadas medidas de peso e altura, e calculou-se o índice de massa corporal (IMC. O estado nutricional pré-gestacional foi determinado de acordo com os seguintes critérios de IMC: baixo peso (30 kg/m². O estado nutricional durante a gestação foi obtido de acordo a com a curva de IMC para idade gestacional adotada pelo Ministério da Saúde no Brasil. Para análise dos dados, utilizou-se o risco relativo e respectivo intervalo de confiança de 95% e os testes t de Student e χ2. Considerou-se significância estatística o valor de pPURPOSE: to evaluate the impact of dietary counseling on controlling weight gain in pregnant women, who were served in a public health service facility. METHODS: the study was conducted at a known health unit located in the metropolitan region of the city of Porto Alegre, in Rio Grande do Sul, Brazil. Three hundred and fifteen pregnant women between the 10th and 29th week of gestation were randomized to Control and Intervention Groups. The Intervention Group received dietary counseling according to nutritional status, and pregnant women in the Control Group were instructed to follow the routine of the health service facility. Weight and height were measured, and the body mass index (BMI was calculated. The pre-gestational nutritional status was determined according to the following BMI criteria: low weight

  12. Placental Aromatase Is Deficient in Placental Ischemia and Preeclampsia.

    Directory of Open Access Journals (Sweden)

    Alejandra Perez-Sepulveda

    Full Text Available Preeclampsia is a maternal hypertensive disorder with uncertain etiology and a leading cause of maternal and fetal mortality worldwide, causing nearly 40% of premature births delivered before 35 weeks of gestation. The first stage of preeclampsia is characterized by reduction of utero-placental blood flow which is reflected in high blood pressure and proteinuria during the second half of pregnancy. In human placenta androgens derived from the maternal and fetal adrenal glands are converted into estrogens by the enzymatic action of placental aromatase. This implies that alterations in placental steroidogenesis and, subsequently, in the functionality or bioavailability of placental aromatase may be mechanistically involved in the pathophysiology of PE.Serum samples were collected at 32-36 weeks of gestation and placenta biopsies were collected at time of delivery from PE patients (n = 16 and pregnant controls (n = 32. The effect of oxygen tension on placental cells was assessed by incubation JEG-3 cells under 1% and 8% O2 for different time periods, Timed-mated, pregnant New Zealand white rabbits (n = 6 were used to establish an in vivo model of placental ischemia (achieved by ligature of uteroplacental vessels. Aromatase content and estrogens and androgens concentrations were measured.The protein and mRNA content of placental aromatase significantly diminished in placentae obtained from preeclamptic patients compared to controls. Similarly, the circulating concentrations of 17-β-estradiol/testosterone and estrone/androstenedione were reduced in preeclamptic patients vs. controls. These data are consistent with a concomitant decrease in aromatase activity. Aromatase content was reduced in response to low oxygen tension in the choriocarcinoma JEG-3 cell line and in rabbit placentae in response to partial ligation of uterine spiral arteries, suggesting that reduced placental aromatase activity in preeclamptic patients may be associated with chronic

  13. [Study on the heterogeneity of edema in severe preeclampsia].

    Science.gov (United States)

    Shi, Junmei; Yang, Zi; Chen, Lei

    2014-05-06

    The aim of this study was to analysis the clinical edema forms and explore the heterogeneity of edema in severe preeclampsia (PE) . From February 2002 to February 2009, Peking University Third Hospital admitted with severe preeclampsia 228 cases who were enrolled in this study. The form is divided into no edema (A-type), pure interstitial edema (B-type), a simple cavity gap edema (C-type) and mixed interstitial edema that coexist with lacunar edema (D-type). Analysis and comparison of various types of edema in patients with different clinical manifestations of prenatal care models, laboratory parameters, the incidence of gestational age, complications and obstetric and perinatal outcomes, and analyze the relationship between different types of edema and albumins and the peak value of proteinuria. Edema was seen in 86% (197/228) of all of cases. Compared the cases who have regular prenatal care with those who have irregular care, differences were statistically significant in edema type composition ratio (P 0.05); Compared early-onset PE and late-onset PE patients, differences were statistically significant in edema type composition ratio (P 0.05). Comparison between the various types of edema, differences were statistically significant in serum albumin levels and peak value of proteinuria and incidence of serious complications and the gestational week at PE onset and the incidence of treatment preterm labor (P edema(P edema were correlated with serum albumin levels (r = -0.19, P 0.05). The manifestations of edema were diverse in severe preeclampsia. The forms of edema were related to the PE onset of gestational age and serious complication involving in different organs.Strengthen prenatal care and early detection of edema may improve adverse obstetric outcomes.

  14. Hyperleptinemia as a Prognostic Factor for Preeclampsia: a Cohort Study

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    Hugo Mendieta Zerón

    2012-01-01

    Full Text Available Introduction: Leptin is an adipokine which has a direct relationship to obesity. Our aim was to measure this hormone in pregnant women at three months intervals throughout their pregnancies to determine the serum value of those who developed preeclampsia. Material and Methods: We followed 19 women (median age 24.8 ± 5.7 years with pre-gestational Body Mass Index (BMI less than 25 kg/m2, 21 (median age 26.1 ± 4.6 years with BMI higher than 25 kg/m2 and 16 (median age 30.9 ± 5.8 years with Gestational Diabetes Mellitus (GDM (median age 30.9 ± 5.8 years, recruited in the 1st trimester of pregnancy. Serum levels of leptin were measured with radioimmunoassay (RIA technique. Results: In the first trimester of pregnancy leptin levels showed statistically significant differences between normal weight and overweight-obese women (p 2 and leptin ≥ 40 ng/ml in the second trimester, the Odds Ratio (OR to develop preeclampsia was of 47.95% CI (4.1–527.2. Analyzing leptin values with ROC curves, the greatest area under the curve (AUC was for leptin in the second trimester (0.773, CI: 0.634–0.911. Conclusion: Women with morbid obesity (BMI ≥ 40 kg/m2 had significantly higher levels of serum leptin (p < 0.01 and a value of 40 ng/ml of this hormone seems to be predictive of developing preeclampsia in this group of patients.

  15. Expectant versus aggressive management in severe preeclampsia remote from term.

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    Sarsam, D S; Shamden, M; Al Wazan, R

    2008-09-01

    Our study aims to compare neonatal and maternal outcomes between expectant (or conservative) and aggressive (or immediate) management in cases with severe preclampsia remote from term. This is a comparative study conducted at Al-Batool Teaching Hospital in Mosul City, Iraq, from April 2003 to August 2004. A total of 74 singleton pregnancies complicated by severe preeclampsia with gestational age of 24-34 weeks were studied during this period. The criteria used for the diagnosis of severe preeclampsia were in accordance with the guidelines of the American College of Obstetricians and Gynaecologists. All the patients were counselled for expectant management. 39 patients were delivered immediately due to refusal of expectant management either by the patient or the attending physician. The other 35 patients were managed expectantly; this group was followed-up and carefully monitored for a period ranging from 72 hours to 18 days. Neonatal parameters, neonatal outcome and maternal outcome were compared between the two groups. The mean value of pregnancy prolongation was 9.2 days. Median gestational age for the first group was 29 weeks, and for the second group, it was 30 weeks. Regarding neonatal parameters, the expectantly-managed group had a higher Apgar score at one minute (3.56 +/- 1.72 vs. 5.05 +/- 1.77, p-value equals 0.001), lower mean days of hospitalisation in the neonatal intensive care unit (6.83 +/- 5.38 vs. 4.50 +/- 3.46, p-value equals 0.03), with a lower incidence of neonatal and maternal complications. Expectant management is recommended in patients with severe preeclampsia remote from term, after proper selection of patients and careful monitoring.

  16. Relation between Serum Ferritin and Iron Parameters with Preeclampsia

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    Robabeh Taheripanah

    2007-06-01

    Full Text Available Objective: Preeclampsia is one of the most important complications of pregnancy that is associated with increased morbidity and mortality. The aim of this study was to investigate the relation between serum iron status and ferritin with pre-eclampsia. Materials and Methods: This case control study evaluated 33 preeclamptic patients and 33 normal pregnant women before parturition in Imam Hossein hospital, from March 2003 till March 2004. Anemia, diabetes and multiple pregnancies were excluded from the study. Blood samples were taken before delivery and patients with HELLP syndrome were considered separately.  Data were analyzed using the SPSS software and P value <0.05 was considered statistically significant. T-test, chi-square and Fisher exact test were used.  Results: The mean of serum iron level in case and control group was 79.9±32.4µg/dl and 88.6±40.8 µg/dl, respectively (NS. TIBC was 443.4±55.0 µmol/l and 383.7±63.6 µmol/l in normal patients and preeclamptics respectively (P = 0.002. Mean serum ferritin was 32.1±16.2 ng/dl in control group and 123.8±46.1 ng/dl in preeclamptics (P<0.001. No meaningful relation was observed between hematocrit, ferritin and iron. Conclusions: Ferritin increases and TIBC decreases in preeclampsia regardless of hepatic function. It seems that elevated serum ferritin (as an oxidative stress can accelerate vascular damage. So, routine iron supplementation in preeclamptic women is questationable.

  17. Pre-eclampsia Diagnosis and Treatment Options: A Review of Published Economic Assessments.

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    Zakiyah, Neily; Postma, Maarten J; Baker, Philip N; van Asselt, Antoinette D I

    2015-10-01

    Pre-eclampsia is a pregnancy complication affecting both mother and fetus. Although there is no proven effective method to prevent pre-eclampsia, early identification of women at risk of pre-eclampsia could enhance appropriate application of antenatal care, management and treatment. Very little is known about the cost effectiveness of these and other tests for pre-eclampsia, mainly because there is no clear treatment path. The aim of this study was to provide a comprehensive overview of the existing evidence on the health economics of screening, diagnosis and treatment options in pre-eclampsia. We searched three electronic databases (PubMed, EMBASE and the Cochrane Library) for studies on screening, diagnosis, treatment or prevention of pre-eclampsia, published between 1994 and 2014. Only full papers written in English containing complete economic assessments in pre-eclampsia were included. From an initial total of 138 references, six papers fulfilled the inclusion criteria. Three studies were on the cost effectiveness of treatment of pre-eclampsia, two of which evaluated magnesium sulphate for prevention of seizures and the third evaluated the cost effectiveness of induction of labour versus expectant monitoring. The other three studies were aimed at screening and diagnosis, in combination with subsequent preventive measures. The two studies on magn