WorldWideScience

Sample records for gere par ordinateur

  1. Vision par ordinateur: outils fondamentaux

    OpenAIRE

    Horaud, Radu; Monga, Olivier

    1995-01-01

    National audience; Cet ouvrage présente les outils fondamentaux de la vision par ordinateur dans un langage mathématique accessible aux étudiants de niveau DEUG en mathématiques ou informatique. Il donne également de nombreux exemples d'utilisation de la vision par ordinateur dans deux domaines de technologie de pointe : la robotique et l'imagerie médicale. Cette deuxième édition largement augmentée est un manuel de référence. Les outils fondamentaux sont présentés dans un langage mathématiqu...

  2. Reseaux d’Antennes Controles par Ordinateur (Computer-Controlled Antenna Arrays).

    Science.gov (United States)

    1977-04-01

    par ordinateur Figure 2. Equivalent electrique de l’antenne Figure 3, Coefficient de reflection Figure 4. Dimensions physique de l’antenne...Figure 5. Photographie de l’antenne dipole Figure 6. Coefficient de reflection de 4 antennes differentes presente sur "Smith Chart" Figure 7. Reglage...transition d’impedance de la ligne 1 transmission (50 OHMS) ä la resistance de radiation d’un dipole dans • ••.pace (73 OHMS). Ces calculs

  3. Developpement d'algorithmes de reconstruction statistique appliques en tomographie rayons-X assistee par ordinateur

    Science.gov (United States)

    Thibaudeau, Christian

    La tomodensitometrie (TDM) permet d'obtenir, et ce de facon non invasive, une image tridimensionnelle de l'anatomie interne d'un sujet. Elle constitue l'evolution logique de la radiographie et permet l'observation d'un volume sous differents plans (sagittal, coronal, axial ou n'importe quel autre plan). La TDM peut avantageusement completer la tomographie d'emission par positrons (TEP), un outil de predilection utilise en recherche biomedicale et pour le diagnostic du cancer. La TEP fournit une information fonctionnelle, physiologique et metabolique, permettant la localisation et la quantification de radiotraceurs a l'interieur du corps humain. Cette derniere possede une sensibilite inegalee, mais peut neanmoins souffrir d'une faible resolution spatiale et d'un manque de repere anatomique selon le radiotraceur utilise. La combinaison, ou fusion, des images TEP et TDM permet d'obtenir cette localisation anatomique de la distribution du radiotraceur. L'image TDM represente une carte de l'attenuation subie par les rayons-X lors de leur passage a travers les tissus. Elle permet donc aussi d'ameliorer la quantification de l'image TEP en offrant la possibilite de corriger pour l'attenuation. L'image TDM s'obtient par la transformation de profils d'attenuation en une image cartesienne pouvant etre interpretee par l'humain. Si la qualite de cette image est fortement influencee par les performances de l'appareil, elle depend aussi grandement de la capacite de l'algorithme de reconstruction a obtenir une representation fidele du milieu image. Les techniques de reconstruction standards, basees sur la retroprojection filtree (FBP, filtered back-projection), reposent sur un modele mathematiquement parfait de la geometrie d'acquisition. Une alternative a cette methode etalon est appelee reconstruction statistique, ou iterative. Elle permet d'obtenir de meilleurs resultats en presence de bruit ou d'une quantite limitee d'information et peut virtuellement s'adapter a toutes formes

  4. Elements Optiques Holographiques Generes Par Ordinateur a Fonction de Phase Semi-Continue et Distribuee

    Science.gov (United States)

    Lemelin, Guylain

    Occupant une place grandissante dans la conception optique, les elements optiques holographiques (EOH) peuvent accomplir des taches qui seraient difficilement rendues par un groupe d'elements optiques conventionnels. Dans plusieurs systemes optiques utilisant une source laser, ces elements holographiques permettent d'imaginer des systemes optiques jusqu'ici impossibles a construire. Par consequent, ce type d'hologramme permet aux concepteurs la fabrication d'elements optiques speciaux. Nous presentons une etude d'EOH a fonction de phase semi-continue et distribuee qui augmente la capacite d'operation de ces elements optiques. Point tournant de notre developpement, nous avons mis au point une methode de fabrication par defocalisation simulee tres efficace, peu couteuse et facile a controler. Nous presentons des EOH simples qui demontrent les caracteristiques de base et des EOH plus complexes mettant en oeuvre des capacites speciales en fonction de leur utilisation specifique. Cette approche de conception optique holographique nous permet d'obtenir des EOH offrant une flexibilite d'optimisation et d'utilisation inegalee, augmentant ainsi les capacites de la conception optique.

  5. Le projet MP5 Gestion de la maintenance assistée par ordinateur

    CERN Document Server

    Oliger, S

    2001-01-01

    L'année 2000 marque un tournant dans la manière d'appréhender l'activité de maintenance dans la division ST. Les méthodes, jusqu'alors basées sur une approche corporative relayée par des outils informatiques d'ancienne génération, ont évolué vers une approche intégrée. Ce document décrit tous les aspects du projet de migration de l'ancien logiciel RAPIER vers le nouveau logiciel MP5: définition des ressources, identification des contraintes et des facteurs de succès critiques, planification, unification des méthodes et des données, migration informatique, formation du personnel et mise en service. Il présente également les intégrations réalisées avec d'autres logiciels, les possibilités d'évolution pour la division et les perspectives de généralisation pour le CERN.

  6. Application de principes cognitivistes et constructivistes à l'enseignement de l'écrit assisté par ordinateur : perceptions des étudiants

    Directory of Open Access Journals (Sweden)

    Catherine Caws

    2005-09-01

    Full Text Available Cet article traite des apports des théories cognitives et constructivistes à l'enseignement de l'écrit assisté par ordinateur, en milieu universitaire, chez des apprenants de français langue seconde. À partir des premiers résultats d'un projet pilote mené à l'université de Victoria, au Canada, l'auteure cherche à montrer comment, par le biais d'exercices collaboratifs en réseau Internet, l'application de certains principes-clés des recherches récentes en didactique du français langue seconde peuvent contribuer à un renouveau de l'engagement des étudiants, à une hausse notable de leur motivation et à une prise de conscience de leurs stratégies d'apprentissage. Une analyse des réactions des étudiants face à ce nouveau type d'apprentissage nous permet d'analyser, d'une part, les aspects de l'outil que les étudiants perçoivent comme étant utiles pour leur apprentissage et, d'autre part, les éléments qu'ils voudraient voir améliorer dans l'avenir. La prise de conscience même de ces stratégies nous montre à quel point l'apprenant s'engage activement dans la découverte de la L2, répondant ainsi inconsciemment à un des principes-clés de la psychologie cognitive.

  7. Numerical analysis of resonances induced by s wave neutrons in transmission time-of-flight experiments with a computer IBM 7094 II; Methodes d'analyse des resonances induites par les neutrons s dans les experiences de transmission par temps de vol et automatisation de ces methodes sur ordinateur IBM 7094 II

    Energy Technology Data Exchange (ETDEWEB)

    Corge, Ch. [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1969-01-01

    Numerical analysis of transmission resonances induced by s wave neutrons in time-of-flight experiments can be achieved in a fairly automatic way on an IBM 7094/II computer. The involved computations are carried out following a four step scheme: 1 - experimental raw data are processed to obtain the resonant transmissions, 2 - values of experimental quantities for each resonance are derived from the above transmissions, 3 - resonance parameters are determined using a least square method to solve the over determined system obtained by equalling theoretical functions to the correspondent experimental values. Four analysis methods are gathered in the same code, 4 - graphical control of the results is performed. (author) [French] L'automatisation, sur ordinateur IBM 7094/II, de l'analyse des resonances induites par les neutrons s dans les experiences de transmission par temps de vol a ete accomplie en la decomposant selon un schema articule en quatre phases: 1 - le traitement des donnees experimentales brutes pour obtenir les transmissions interfero-resonnantes, 2 - la determination des grandeurs d'analyse a partir des transmissions precedentes, 3 - l'analyse proprement dite des resonances dont les parametres sont obtenus par la resolution d'un systeme surabondant. Quatre methodes d'analyse sont groupees en un meme programme, 4 - la procedure de verification graphique. (auteur)

  8. Le début d'une nouvelle vie pour de vieux ordinateurs | IDRC ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    25 janv. 2011 ... Un projet financé par le CRDI qui fournit des ordinateurs aux écoles tout en créant des emplois permet de s'attaquer au problème environnemental causé par les déchets électroniques en Amérique latine et dans les Caraïbes.

  9. Algorithmes et architectures pour ordinateurs quantiques supraconducteurs

    Science.gov (United States)

    Blais, A.

    2003-09-01

    Algorithms and architectures for superconducting quantum computers Since its formulation, information theory was based, implicitly, on the laws of classical physics. Such a formulation is however incomplete because it does not take into account quantum reality. During the last twenty years, expansion of theory information to include quantum effects has known growing interest. The practical realization of a system for quantum data processing system, a quantum computer, presents however many challenges. In this book, we are interested in various aspects of these challenges. We start by presenting algorithmic concepts like optimization of quantum computations and geometric quantum computation. We then consider various designs and aspects of qubits based on Josephson junctions. In particular, an original approach to the interaction between superconducting qubits is presented. This approach is very general since it can be applied to various designs of qubits. Finally, we are interested in read-out of the superconductic flux qubits. The detector suggested here has the advantage that it is possible to uncouple it from the qubit when no measurement is in progress. Depuis sa formulation, la théorie de l'information a été basée, implicitement, sur les lois de la physique classique. Une telle formulation est toutefois incomplète puisqu'elle ne tient pas compte de la réalité quantique. Au cours des vingt dernières années, l'expansion de la théorie de l'information, de façon à englober les effets purement quantiques, a connu un intérêt grandissant. La réalisation d'un système de traitement de l'information quantique, un ordinateur quantique, présente toutefois de nombreux défis. Dans cet ouvrage, on s'intéresse à différents aspects concernant ces défis. On commence par présenter des concepts algorithmiques comme l'optimisation de calculs quantiques et le calcul quantique géométrique. Par la suite, on s'intéresse à différents designs et aspects de l

  10. Vision pour ordinateur : réalisation d'un système d'aide au diagnostic par analyse d'images échocardiographiques en mode TM

    OpenAIRE

    Farssi, S.M.; Diop, O.; Corenthin, A.; Sow, G.; Ka, M.

    1994-01-01

    L'échographie est aujourd'hui considérée comme étant une méthode d'imagerie compétitive par rapport à d'autres techniques d'examen complémentaire comme la radiologie ou la médecine nucléaire. Dans cet article, nous présentons une solution permettant d'évaluer la fraction de raccourcissement et d'épaississement sur les indexs, entre la diastole et la systole, dans le cadre d'un projet de recherche liant le laboratoire au C.H.U. Aristide le Dantec de Dakar. (D'après résumé d'auteur)...

  11. Automation on computer of the partial area method in the analysis of resonances induced by 'S' neutrons 2. with an interference term and extension of the method to the treatment of multi resonances (1963); Automatisation sur ordinateur de la methode des aires partielles dans l'analyse des resonances induites par les neutrons ''S''. 2, avec terme d'interference et extension de la methode au traitement des multiresonances (1963)

    Energy Technology Data Exchange (ETDEWEB)

    Bianchi, G.; Corge, C.R. [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1963-07-01

    This report deals with the numerical analysis on an I.B.M. 7090 computer of transmission resonances induced by 's' wave neutrons in time of flight experiments. The analysis method used is the partial area one. In this second part the interference term is taken into account. Modifications have been made in the programs and subroutines described in the first part, to determine the resonant transmissions from experimental raw data, and the relating partial areas. Also programs and subroutines are thoroughly described, which estimate the resonance parameters. The field of the partial area method has been extended to cover the case where several resonances have to be treated simultaneously, provided they do not interfere. (authors) [French] Le pretent rapport a pour objet l'analyse numerique sur ordinateur I.B.M. 7090 des resonances dues aux neutrons ''s'' dans les experiences de transmission par temps de vol, la methode d'analyse utilisee etant la methode dea aires partielles. Dans cette deuxieme partie il a ete tenu compte du terme d'interference. On y trouvera une description des amenagements apportes aux programmes et sous-programmes decrits dans la premiere partie pour determiner les transmissions interfero-resonnantes a partir des donnees experimentales brutes et les aires partielles afferentes. Sont egalement decrits les programmes et sous-programmes necessaires au calcul des parametres caracteristiques des resonances. Le domaine d'application de la methode a ete etendu au traitement simultane de plusieurs resonances groupees n'interferant pas entre elles. (auteurs)

  12. Environmental Assessment of the Gering-Stegall 115-kV Transmission Line Consolidation Project, Scotts Bluff County, Nebraska

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-05-01

    The Department of Energy (DOE), Western Area Power Administration (Western) proposes to consolidate segments of two transmission lines near the Gering Substation in Gering, Nebraska. The transmission lines are both located in Scotts Bluff County, Nebraska. The transmission lines are both located in Scotts Bluff County, Nebraska, within the city of Gering. Presently, there are three parallel 115-kilovolt (kV) transmission lines on separate rights-of-way (ROW) that terminate at the Gering Substation. The project would include dismantling the Archer-Gering wood-pole transmission line and rebuilding the remaining two lines on single-pole steel double circuit structures. The project would consolidate the Gering-Stegall North and Gering-Stegall South 115-kV transmission lines on to one ROW for a 1.33-mile segment between the Gering Substation and a point west of the Gering Landfill. All existing wood-pole H-frame structures would be removed, and the Gering-Stegall North and South ROWs abandoned. Western is responsible for the design, construction, operation, and maintenance of the line. Western prepared an environmental assessment (EA) that analyzed the potential environmental impacts of the proposed construction, operation, and maintenance of the 115-kV transmission line consolidation. Based on the analyses in the EA, the DOE finds that the proposed action is not a major Federal action significantly affecting the quality of the human environment, within the meaning of the National Environmental Policy Act of 1969 (NEPA).

  13. Environmental Assessment of the Gering-Stegall 115-kV Transmission Line Consolidation Project, Scotts Bluff County, Nebraska

    International Nuclear Information System (INIS)

    1995-05-01

    The Department of Energy (DOE), Western Area Power Administration (Western) proposes to consolidate segments of two transmission lines near the Gering Substation in Gering, Nebraska. The transmission lines are both located in Scotts Bluff County, Nebraska. The transmission lines are both located in Scotts Bluff County, Nebraska, within the city of Gering. Presently, there are three parallel 115-kilovolt (kV) transmission lines on separate rights-of-way (ROW) that terminate at the Gering Substation. The project would include dismantling the Archer-Gering wood-pole transmission line and rebuilding the remaining two lines on single-pole steel double circuit structures. The project would consolidate the Gering-Stegall North and Gering-Stegall South 115-kV transmission lines on to one ROW for a 1.33-mile segment between the Gering Substation and a point west of the Gering Landfill. All existing wood-pole H-frame structures would be removed, and the Gering-Stegall North and South ROWs abandoned. Western is responsible for the design, construction, operation, and maintenance of the line. Western prepared an environmental assessment (EA) that analyzed the potential environmental impacts of the proposed construction, operation, and maintenance of the 115-kV transmission line consolidation. Based on the analyses in the EA, the DOE finds that the proposed action is not a major Federal action significantly affecting the quality of the human environment, within the meaning of the National Environmental Policy Act of 1969 (NEPA)

  14. German Environmental Survey for Children (GerES IV)--first results.

    Science.gov (United States)

    Kolossa-Gehring, Marike; Becker, Kerstin; Conrad, André; Lüdecke, Anja; Riedel, Stefan; Seiwert, Margarete; Schulz, Christine; Szewzyk, Regine

    2007-10-01

    German Environmental Surveys (GerESs) are large scale population studies which have been carried out on adults in 1985/86, 1990/92 and 1998 and on children aged 6-14 years in 1990/92. GerES IV is the first survey focussing exclusively on children [Becker, K., Schulz, C., Babisch, W., Dürkop, J., Roskamp, E., Seiwert, M., Szewzyk, R., Ullrich, D., Seifert, B., 2005. German Environmental Survey for Children (GerES IV) 2003-2006. Pullut. Atmos. 188, 475-479]. GerES IV included a representative sample of 1790 children aged 3-14 of the participants of the National Health Interview and Examination Survey on Children and Adolescents. The primary goal of GerES IV is not only to analyse and document the extent, distribution and determinants of German children's exposure to environmental pollutants but to discover links between environmental exposure and health. Results will help develop preventive measures and advance further research. They might provide the basis for environmental and public health policy decisions. Precondition to achieve this task is a description of the data on exposures and the data on health outcomes. This work is currently performed at the Federal Environment Agency. First results show a remarkable decrease of the blood lead level of German children aged 6-14 years from 32.3 microg/l in 1990/92 (GerES II) to 16.3 microg/l in GerES IV which is the lowest mean lead concentration determined in German studies so far. None of the children had a value exceeding 100 microg/l. In GerES IV, the following health-related issues will be primarily examined: the relationship between sensitisation against mould spores and the occurrence of mould in households, irritation of eyes and respiratory system caused by formaldehyde, other aldehydes, or total volatile organic compounds (TVOC); the impact of non-occupational noise on hearing loss, stress and sleep disturbances, and the connection between contact allergies, nickel and scents. 9.5% of the children showed a

  15. Rédactions conversationnelles sur papier et sur ordinateur: une étude de cas Collaborative writing on paper and on computer: a case study

    Directory of Open Access Journals (Sweden)

    Charlotte Dejean

    2003-06-01

    Full Text Available Très récemment encore, le modèle de l'apprenant seul face à l'ordinateur était dominant car l'ordinateur était considéré avant tout comme un outil favorisant l'individualisation de l'apprentissage. Depuis quelques années, les technologies au service de l'apprentissage sont envisagées comme pouvant faciliter les interactions sociales (enseignant-apprenants et apprenants-apprenants. C'est dans cette perspective que s'est développé, notamment dans le monde anglophone, un domaine de recherche sur les Apprentissages Collaboratifs Assistés par Ordinateur (ACAO. Les situations de travail auxquelles s'intéresse ce domaine sont le travail à deux ou plusieurs face à un même ordinateur et le travail à plusieurs par le biais de l'ordinateur, c'est-à-dire en réseau (local ou Internet. La situation qui fait l'objet de cette étude relève de la première catégorie évoquée; on s'intéresse en effet aux interactions entre deux apprenants de Français Langue Étrangère (FLE, rédigeant ensemble un texte avec un même ordinateur. Ces apprenants participent donc à ce que l'on appelle une "rédaction conversationnelle" ou une rédaction collaborative.Until fairly recently, the model of the learner working alone before a computer was prevailing, since the computer was considered as a tool favoring the individualization of the learning process. In the last few years, technologies associated with learning have been considered to be able to facilitate social interactions (teacher-learners and learners-learners. With this in mind, a domain of research concerning Computer Supported Collaborative Learning (CSCL, has been developed, particularly in the English-speaking world. This domain of research is interested in work situations involving two or more people interacting around the same computer, and several people interacting through computers on a networked system (local or Internet. The object of this study relates to the first situation

  16. Esthétique ordinaire et chats : ordinateur, corporéité et expression codifiée des affects

    OpenAIRE

    Frias, Anibal

    2007-01-01

    Cet article aborde la créativité ordinaire sur ordinateur et les usages de graphismes codifiés, les smileys. Ceux-ci expriment les affects des internautes au cours des interactions médiatisées par l’ordinateur, marquant une téléprésence sensible et un triple lien : ludique, éthique et esthétique. L’expressivité du visage et la sexualité sont les deux principales sphères qui émergent de cette interactivité. Contrairement à l’idée d’une disparition postmoderne du corps, avec le numérique, la co...

  17. Modelos de valor agregado para medir a eficácia das escolas Geres

    OpenAIRE

    Soares, Tufi Machado; Bonamino, Alicia; Brooke, Nigel; Fernandes, Neimar da Silva

    2017-01-01

    Resumo A partir da pesquisa longitudinal Geres, o estudo propõe a comparação de diferentes modelos estatísticos com graus variados de complexidade para determinar a eficácia de escolas de Ensino Fundamental. O propósito da comparação é o de determinar se um grau maior de complexidade se justifica em termos de maior precisão e se há diferenças entre os modelos na sua consistência e capacidade de retratar de modo estável o desempenho da escola. Os dois modelos mais simples da contribuição da es...

  18. The German Environmental Survey for Children (GerES IV): Reference values and distributions for time-location patterns of German children

    OpenAIRE

    Conrad, André; Seiwert, Margarete; Hünken, Andreas; Quarcoo, David; Schlaud, Martin; Groneberg, David

    2012-01-01

    Children's time-location patterns are important determinants of environmental exposure and other health-relevant factors. Building on data of the German Environmental Survey for Children (GerES IV), our study aimed at deriving reference values and distributions for time-location patterns of 3–14-year-old German children. We also investigated if GerES IV data are appropriate for evaluating associations with children's health determinants by linking them to data of the National Health Interview...

  19. L'Enseignement des langues assiste par ordinateur: nouvelle pedagogie? (Computer Assisted Language Instruction: New Pedagogy?).

    Science.gov (United States)

    Elkabas, Charles

    1989-01-01

    Recent second language instruction computer software focuses almost exclusively on the structures and forms of language, and on programed learning instead of developing communicative skills. Until artificial intelligence changes these old behavioristic principles, computer-assisted language instruction can only play a minor role in language…

  20. Le CO.C.A.O: le commentaire de carte assisté par ordinateur

    Directory of Open Access Journals (Sweden)

    Joël CHARRE

    1991-12-01

    Full Text Available Le contenu d’une carte topographique peut être enregistré informatiquement sous forme d’un Système d’Information Géographique (SIG raster. En changeant de support, l’information change de nature: de fixe, elle devient manipulable, adaptable, vivante. L’analyse spatiale peut alors reposer sur des mesures de superficies, des fréquences de co-occurrences, des proximités...

  1. La pratique du francais assiste par ordinateur (The Application of Computer-Assisted French).

    Science.gov (United States)

    Malandain, Jean-Louis

    1985-01-01

    Language teachers are urged to explore, develop, and use the entire range of applications made possible by the computer and to realize that the computer can do almost anything but generate ideas. (MSE)

  2. Une Experience d'enseignement du francais par ordinateur (An Experiment in Teaching French by Computer).

    Science.gov (United States)

    Bougaieff, Andre; Lefebvre, France

    1986-01-01

    An experimental program for university summer students of French as a second language that provided a computer resource center and a variety of courseware, authoring aids, and other software for student use is described and the problems and advantages are discussed. (MSE)

  3. Un Cours de composition francaise par ordinateur (A Computer-Based Course in French Composition).

    Science.gov (United States)

    Landes, Anne; Kaplan, Alice

    1988-01-01

    The origins, organization, and methods of a Columbia University course offering computer-based instruction in French composition are outlined, and the progress of four individual students is described. (MSE)

  4. CARTGRL: Un logiciel de cartographie thématique pour micro-ordinateurs

    Directory of Open Access Journals (Sweden)

    Pierre DUMOLARD

    1986-03-01

    Full Text Available CARTGRL est un logiciel simple d'expérimentation cartographique sur micro-ordinateur standard. Ce logiciel gère des fonds de carte de type raster. Les illustrations portent sur le chômage en France.

  5. Estudo longitudinal sobre qualidade e equidade no ensino fundamental brasileiro: GERES 2005 Estudio longitudinal sobre cualidad y equidad en la enseñanza fundamental brasileña: GERES 2005 Longitudinal study of quality and equity in the Brazilian elementary education: GERES 2005

    Directory of Open Access Journals (Sweden)

    Creso Franco

    2008-12-01

    Full Text Available Este artigo apresenta o relato do desenho metodológico do "Estudo longitudinal sobre qualidade e eficácia no ensino fundamental brasileiro: GERES 2005". O GERES ainda está em desenvolvimento e sua principal característica é o acompanhamento de uma mesma amostra de alunos dos anos iniciais do ensino fundamental ao longo de quatro anos. Cinco cidades participam do estudo, a saber: Belo Horizonte (MG, Rio de Janeiro (RJ, Salvador (BA, Campinas (SP e Campo Grande (MS. O estudo começou em 2005 e envolve a aplicação de testes cognitivos em Leitura e em Matemática, bem como questionários contextuais para alunos, professores e diretores das escolas participantes. A Teoria de Resposta ao Item Paramétrica tem sido utilizada com o propósito de equalização das escalas para os diferentes níveis de escolarização (anos ou seus equivalentes, de modo que seja possível obter uma curva de crescimento da proficiência ao longo do tempo para cada aluno observado. O GERES tem como objetivo central investigar quais práticas pedagógicas e condições escolares contribuem para a promoção da eficácia e da eqüidade escolar, tendo como principal abordagem analítica a utilização de modelos multiníveis.Este artículo presenta relato del diseño metodológico del "Estudio longitudinal sobre cualidad y eficacia en la enseñanza fundamental brasileña: GERES 2005". El GERES aún está en desenvolvimiento y su principal característica es el acompañamiento de una misma muestra de alumnos de los años iniciales de la enseñanza fundamental al longo de cuatro años. Cinco ciudades participan del estudio, a saber: Belo Horizonte (MG, Rio de Janeiro (RJ, Salvador (BA, Campinas (SP e Campo Grande (MS. El estudio comenzó en 2005 y envuelve la aplicación de testes cognitivos en Lectura y en Matemática, bien como cuestionarios contextuales para alumnos, profesores y directores de las escuelas participantes. La Teoría de Respuesta al Ítem Param

  6. Les temps de l’archivage de terrain. Les documents intermédiaires, du papier à l’ordinateur

    Directory of Open Access Journals (Sweden)

    Georges Augustins

    2008-08-01

    Full Text Available Les temps de l’archivage de terrain. Les documents intermédiaires, du papier à l’ordinateur. La revisite de terrains ethnologiques passés fournit l’occasion de faire le point sur les méthodes employées et leur évolution entre deux moments de la recherche. Elle permet également le passage et la continuité des travaux d’un ethnologue vers un autre. Nous traiterons ces deux angles au travers d’une expérience concrète réalisée sur les travaux ethnologiques des Baronnies de Bigorre. Outre les présentations des deux enquêtes de terrain, la première effectuée de 1974 à 1976 et la seconde fin 2005/début 2006, nous interrogerons les différences dans la pratique ethnographique et les raisons du changement, puis nous nous poserons la question de l’utilisation des documents intermédiaires du premier ethnologue par le second.The times of archiving the fieldwork. Intermediary documents, from paper to computer. Revisiting areas studied by anthropologists in the past provides an opportunity to take stock of the methods used and how they have evolved between two periods of research. It also enables work to continue and be passed from one anthropologist to another. We shall look at both these angles using an actual experiment carried out on the ethnological work in the Baronnies de Bigorre region. As well as presenting both of the field surveys, the first carried out from 1974 to 1976 and the second from the end of 2005 into early 2006, we shall be examining the differences in ethnological practices and the reasons behind these changes, and then looking at how the second anthropologist has made use of the first anthropologist’s intermediary documents.

  7. Measurement network for atmospheric radioactivity managed by ASPA; Le reseau de surveillance de la radioactivite atmospherique gere par l'ASPA

    Energy Technology Data Exchange (ETDEWEB)

    Clauss, G. [Association pour la surveillance et l' etude de la pollution atmospherique en Alsace, poles technique et qualite, 67 - Tanneries (France)

    2010-06-15

    It was after the Chernobyl accident that a management committee of the radioactivity in Alsace has been put in place (composed of representatives from state, local governments, scientific organizations and associations). This committee entrusted ASPA to manage a measurement network for radioactivity in Alsace composed of 5 stations. ASPA provides automatic communication of results hourly on its web-site www.atmo-alsace.net/site/Radioactivite-13.html to enable its members and the public to have at any time information of artificial radioactivity in air in Alsace. In case of validated alarm, ASPA performs further analysis, meets the surveillance group and complete information through special announcements. (author)

  8. Le francais assiste par ordinateur des colleges et des universities du Canada (French CALL in Canadian Colleges and Universities).

    Science.gov (United States)

    Bougaieff, Andre

    This directory presents the results of a national survey of Canadian colleges and universities concerning faculty's use of computer-assisted French language instruction. The listings, arranged alphabetically by province or territory, and within these by institution, contain the responding faculty member's name, address, e-mail address, fax and…

  9. Enhanced CAX Architecture, Design and Methodology - SPHINX (Architecture, definition et methodologie ameliorees des exercices assistes par ordinateur (CAX) - SPHINX)

    Science.gov (United States)

    2016-08-01

    Manuel MACIA GARCIA CENAD SAN GREGORIO Acto. GENERAL QUINTANA CENAD / Centro Simulación Casiopea Spanish Army Zaragoza Crtra. N-330, Km-503... landscape . Figure B-1: NATO C3 Taxonomy. ANNEX B – SPHINX TOOL STO-TR-MSG-106 B - 5 C3 taxonomy can be exploited to support the implementation

  10. Les apports de l'experimentation assistee par ordinateur (ExAO) en pedagogie par projet en Sciences de la nature au collegial

    Science.gov (United States)

    Marcotte, Alice

    The goals of this research were to conceptualize and to produce a test synthesis model for the Sciences program, where the student had to demonstrate his or her competency using the approach Considering New Situations from Acquired Knowledge. The test took the form of a student-structured project utilizing the experimental process: the student's scientific investigation was supported and facilitated by computer-assisted experimentation (CAEx). The model of action was elaborated in developmental research within the school setting, tested in biology, and continued in an interdisciplinary context. Our study focused on the advantages and the constraints of this new learning environment, which modify laboratories using traditional instrumentation. The final research was not to evaluate a type of test synthesis, but to propose and to improve this model of test synthesis based on experimental process and supported by CAEx. In order to implement the competency approach within an integration activity, we chose a cooperative learning environment contained within the pedagogical project. This didactic environment was inspired by socio-constructivism which involves students in open scientific problem-solving. Computer-assisted experimentation turned out to be a valuable tool for this environment, facilitating the implementation of the scientific process by increased induction. Resistance to confronted and uncircumvented reality changes students' perception of scientific knowledge. They learn to integrate the building of this knowledge, and then to realize the extent of their learning and their training. Students' opinions, which were gathered from questionnaires, reveal that they favorably perceive this type of environment in interaction with their peers and the experimentation. While this new knowledge contributes to CAEx within the pedagogical project, the products of this research included a teaching guide for the test synthesis, a booklet featuring the projects carried out by the students with CAEx, and the proposals to renew the didactic approach in the laboratory.

  11. The German Environmental Survey for Children (GerES IV): reference values and distributions for time-location patterns of German children.

    Science.gov (United States)

    Conrad, André; Seiwert, Margarete; Hünken, Andreas; Quarcoo, David; Schlaud, Martin; Groneberg, David

    2013-01-01

    Children's time-location patterns are important determinants of environmental exposure and other health-relevant factors. Building on data of the German Environmental Survey for Children (GerES IV), our study aimed at deriving reference values and distributions for time-location patterns of 3-14-year-old German children. We also investigated if GerES IV data are appropriate for evaluating associations with children's health determinants by linking them to data of the National Health Interview and Examination Survey for Children and Adolescents (KiGGS). Parents reported on the time their children usually spend at home, in other indoor environments, and outdoors. This information was characterized by statistical parameters, which were also calculated for different strata concerning socio-demography and the residential environment. Consequently, group differences were evaluated by t-tests and univariate ANOVA. Reference distributions were fitted to the time-location data by a Maximum Likelihood approach to make them also useable in probabilistic exposure modeling. Finally, associations between data on the children's physical activity as well as body weight and their outdoor time were investigated by bivariate correlation analysis and cross tabulation. On daily average, German children spend 15 h and 31 min at home, 4 h and 46 min in other indoor environments, and 3 h and 43 min outdoors. Time spent at home and outdoors decreases with age while time spent in other indoor environments increases. Differences in time-location patterns were also observed for the socio-economic status (SES) and immigration status. E.g., children with a high SES spend 24 min less outdoors than low SES children. Immigrants spend on daily average 20 min more at home and 15 min less outdoors than non-immigrant children. Outdoor time was associated with parameters of the residential environment like the building development. Children living in 1- or 2-family houses spend more time outdoors than

  12. La guerrière colombienne à l'ordinateur portatif : la connectivité au ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    3 févr. 2011 ... Les barons de la drogue essaient d'inciter les paysans paez pauvres à cultiver pour leur entreprise illicite mais lucrative de l'opium, de la marijuana ou de la coca, selon l'altitude et le terrain. Dans le cadre du Plan Colombia, campagne antidrogue financée par les États-Unis, le gouvernement colombien ...

  13. Plateforme régionale sur les ordinateurs personnels, déchets ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Institution. SUR Corporación de Estudios Sociales y Educación. Pays d' institution. Chili. Contenus connexes. Un numéro spécial de la revue met en lumière les conclusions d'une étude financée par le CRDI sur le travail rémunéré des femmes. Policy in Focus publie un numéro spécial présentant des données probantes ...

  14. German Environmental Survey of Children (GerES IV) - environmental module of KiGGS. Pt. 1. Design and research programme; Kinder-Umwelt-Survey - das Umweltmodul im KiGGS. Teil 1. Konzeption und Untersuchungsprogramm

    Energy Technology Data Exchange (ETDEWEB)

    Schulz, C.; Babisch, W. [Umweltbundesamt, Berlin (Germany); Becker, K. [Umweltbundesamt, Berlin (DE)] (and others)

    2004-11-15

    The German Environmental Survey for Children (GerES IV) is the environment-oriented module of the National Health Interview and Examination Survey for Children and Adolescents (KiGGS) which is being performed nationwide in Germany. Form 2003 to 2006, a random subsample of 1800 children aged 3-14 years is being studied with regard to their body burden and health impairments linked to housing conditions and the personal environment- and health-relevant behaviour. The basic study programme includes the analysis of blood, urine, tap water and house dust as well as the application of an extensive questionnaire. The data gained from this population sample, which is representative for Germany's children, are the basis for deriving reference values to characterise the background exposure of children aged 3-14 years. Trends over time can be detected and the success of environmental policies verified by comparing the data with those of the German Environmental Survey 1990/92 (GerES II), also conducted in close cooperation with the National Health Survey, which included children aged 6-14 years. By linking the data from the Environmental and the Health Surveys, health-relevant environmental exposures can be detected and different scientific hypotheses can be tested. The main subjects that are being dealt with using subcollectives of GerES IV are ''VOC and eye and nasopharynx irritation'', ''indoor allergens and allergic diseases of the respiratory system'', ''chromium, nickel, fragrances and contact allergens'', and ''noise, hearing capacity and stress hormones''. (orig.)

  15. Espaces de formes basés sur des arbres : définition et applications en traitement d'images et vision par ordinateur

    OpenAIRE

    Xu , Yongchao

    2013-01-01

    In a large number of applications, the processing relies on objects or area of interests, and the pixel-based image representation is notwell adapted. These applications would benefit from a region-based processing. Early examples of region-based processing can be found in the area of image segmentation, such as the quad tree. Recently, in mathematical morphology, the connected operators have received much attention. They are region-based filtering tools that act by merging flat zones. They h...

  16. Processus d'apprentissage a distance et teleconference assistee par ordinateur: essai d'analyse (The Process of Distance Learning and Teleconferencing Assisted by Computer: An Analytic Essay).

    Science.gov (United States)

    Henri, France

    1992-01-01

    Discusses the distance learning process that occurs when computer-mediated communication is used and presents a conceptual framework based on the theoretical principles developed by Gavriel Salomon. Characteristics of the technology are identified, including active user participation, activation of cognitive skills related to information…

  17. Bulletin bibliographique sur l'E.A.O. (l'enseignement assiste par ordinateur) (Bibliographic Bulletin on Computer Assisted Instruction). Publication K-4.

    Science.gov (United States)

    LaForge, Lorne, Ed.

    The bibliography contains about 150 citations of journal articles, monographs, collected works, research reports, and essays drawn from the BIBELO database and concerning computer-assisted language instruction. The first half of the volume is an annotated bibliography in alphabetical order by author. The second section contains subject and…

  18. Intégrer un interprète dans les consultations de médecine familiale : une analyse de discours assistée par ordinateur

    Directory of Open Access Journals (Sweden)

    Yvan Leanza

    2014-12-01

    Full Text Available We set up a research to explore representations of working with interpreters among family physicians in Quebec City. Focus-groups (FGs with third year medical students (6, N= 22, residents (4, N= 29 and senior physicians (5, N= 47 were conducted. We made three video vignettes of interpreted medical consultations. Each FG was presented two of them which were separately discussed. Results show that vignettes and status did elicit different discourses. Students seem more preoccupied with the physician-patient relationship whereas seniors discuss more about information. Residents’ discourse point to identity formation issues. Results are discussed in light of Habermas’ communication theory.

  19. Le resume de texte: une activite de production en langue etrangere assistee par ordinateur (Abstracting: A Computer-Assisted Foreign Language Production Activity).

    Science.gov (United States)

    Janitza, Jean

    1985-01-01

    A productive language exercise that uses the computer and a variation on the cloze procedure by deleting every third word and requiring the student to insert a grammatically and thematically acceptable term is described. (MSE)

  20. FooPar

    DEFF Research Database (Denmark)

    Hargreaves, F. P.; Merkle, D.

    2013-01-01

    We present FooPar, an extension for highly efficient Parallel Computing in the multi-paradigm programming language Scala. Scala offers concise and clean syntax and integrates functional programming features. Our framework FooPar combines these features with parallel computing techniques. Foo...

  1. suPAR

    DEFF Research Database (Denmark)

    Hodges, Gethin W; Bang, Casper N; Wachtell, Kristian

    2015-01-01

    The fundamental role of inflammation in cardiovascular disease (CVD) has prompted interest in numerous biomarkers that detect subclinical levels of inflammation. Soluble urokinase plasminogen activator receptor (suPAR) is a novel biomarker that correlates significantly with cardiovascular events...... comprehensive review of suPAR in CVD and explore its function and usefulness in predicting cardiovascular events....

  2. Par Pond water balance

    International Nuclear Information System (INIS)

    Hiergesell, R.A.; Dixon, K.L.

    1996-06-01

    A water budget for the Par Pond hydrologic system was established in order to estimate the rate of groundwater influx to Par Pond. This estimate will be used in modeling exercises to predict Par Pond reservoir elevation and spillway discharge in the scenario where Savannah River water is no longer pumped and discharged into Par Pond. The principal of conservation of mass was used to develop the water budget, where water inflow was set equal to water outflow. Components of the water budget were identified, and the flux associated with each was determined. The water budget was considered balanced when inflow and outflow summed to zero. The results of this study suggest that Par Pond gains water from the groundwater system in the upper reaches of the reservoir, but looses water to the groundwater system near the dam. The rate of flux of groundwater from the water table aquifer into Par Pond was determined to be 13 cfs. The rate of flux from Par Pond to the water table aquifer near the dam was determined to be 7 cfs

  3. Essai d’une méthodologie d’analyse des données d’Internet sur un ordinateur

    Directory of Open Access Journals (Sweden)

    Géraldine Foin

    2017-01-01

    Full Text Available Dans l’étude de l’environnement numérique dans lequel les individus vivent et évoluent, des problèmes méthodologiques peuvent se poser pour les chercheurs en sciences humaines et sociales. Cet article s’interroge sur la compatibilité des outils classiques en sciences sociales pour l’étude des pratiques numériques sur un écran, celui de l’ordinateur. En effet, l’usage classique d’entretiens, de questionnaires ou d’observations ne suffit plus pour recueillir avec précision les données relatives à Internet et ses écrans (pratique et consommation. Nous proposons une méthodologie complémentaire aux outils non numériques.

  4. Extraction liquide-liquide des sels minéraux. Approximation analytique des isothermes de partage. Application au calcul sur ordinateur d'une installation Liquid-Liquid Extraction of Mineral Salts. Analytical Approximation of Partition Isotherms. Application to the Computer Designing of an Installation

    Directory of Open Access Journals (Sweden)

    Chaid M. T.

    2006-11-01

    Full Text Available Cet article comporte deux parties -dans la première on a calculé les isothermes de partage en partant des considérations thermodynamiques basées sur les travaux de Guggenheim. Les résultats ne sont bons que dans le cas des solutions idéales. On a donc simulé les isothermes par des fonctions analytiques. Celles-ci permettent de représenter convenablement tous les faisceaux d'isothermes quelles que soient l'acidité de la solution aqueuse et les concentrations dans les deux phases; - la deuxième partie est réservée au calcul d'une installation complète d'extraction avec colonne de récupération; le calcul, mené sur ordinateur, utilise les fonctions analytiques précédentes et permet d'obtenir les débits et les concentrations à chaque plateau. This article contains two parts: - the first part discusses the calculating of partition isotherms using thermodynamic considerations based on research by Guggenheim. The results are good only in the case of ideal solutions. Therefore, isotherms were simulated by ànalyticfunctionswhich are suitable for representing all isotherm bundles no matter what the acidity of the aqueous solution and the concentrations in both phases moy be. - the second part 'deals' with designing a complete extraction installation with a recovery column. Computerized designing makes use of the preceding analytic functions and enables flowrates and concentrations ta be determined at each plate.

  5. suPAR: the molecular crystal ball

    DEFF Research Database (Denmark)

    Thunø, Maria; Macho, Betina; Eugen-Olsen, Jesper

    2009-01-01

    soluble urokinase Plasminogen Activator Receptor (suPAR) levels reflect inflammation and elevated suPAR levels are found in several infectious diseases and cancer. suPAR exists in three forms; suPAR(I-III), suPAR(II-III) and suPAR(I) which show different properties due to structural differences. ...

  6. Parálisis cerebral :

    OpenAIRE

    Giral Lamenca, Mónica

    2015-01-01

    Se aborda el tema de la parálisis cerebral definiendo qué es, clasificando los tipos de parálisis dependiendo de la afectación y las características principales. Se explican algunos de sus tratamientos, se dan sistemas alternativos y/o aumentativos de comunicación para un alumno con PC (parálisis cerebral).

  7. Revised and new reference values for environmental pollutants in urine or blood of children in Germany derived from the German environmental survey on children 2003-2006 (GerES IV).

    Science.gov (United States)

    Schulz, Christine; Angerer, Jürgen; Ewers, Ulrich; Heudorf, Ursel; Wilhelm, Michael

    2009-11-01

    Based on the representative data collection of the German Environmental Survey on Children 2003-2006 (GerES IV) the Human Biomonitoring Commission of the German Federal Environment Agency has updated the reference values for a comprehensive number of environmental pollutants in blood and urine of children in Germany. Reference values are statistically derived values that indicate the upper margin of background exposure to a given pollutant in a given population at a given time. They can be used as criteria to classify the measured values of individuals or population groups as being "elevated" or "not elevated". Since environmental conditions are changing, reference values are continuously checked and updated if new information becomes available. Therefore, the previously derived reference values for metabolites of pyrethroids (cis-, trans-Cl(2)Ca and 3-PBA: 1, 2, and 2microg/l), of PAH (1-hydroxypyrene: 0.5microg/l), for arsenic in urine (15microg/l), and for PCB 138, PCB 153, PCB 180 in whole blood (0.3, 0.4, 0.3microg/l) and for DDE (western Germany) in whole blood (0.7microg/l) were confirmed. The following reference values were lowered: lead in blood from 50 to 35microg/l, cadmium in urine from 0.5 to 0.2microg/l, mercury in whole blood from 1.0 to 0.8microg/l, mercury in urine from 0.7 to 0.4microg/l, beta-HCH in whole blood from 0.3 to 0.1microg/l, HCB in whole blood from 0.3 to 0.2microg/l, and DMP in urine from 135 to 75microg/l, and DMTP in urine from 160 to 100microg/l. Based on the extended data set of the GerES IV, the reference value for the sum of PCB 138+153+180 in whole blood of children aged 7 to 14 was raised from 0.9 to 1.0microg/l. The reference value for DEP in urine of children aged 3 to 14 was raised from 16 to 30microg/l. New reference values in urine of children aged 3 to 14 living in Germany were derived for antimony (0.3microg/l), nickel (4.5microg/l), thallium (0.6microg/l), uranium (0.04microg/l), metabolites of organophosphorous

  8. Datation par thermoluminescence

    Directory of Open Access Journals (Sweden)

    1976-01-01

    Full Text Available Depuis 1953, de nombreux chercheurs se sont intéressés à la datation par thermoluminescence de minéraux anciennement brûlés ou cuits. Dans ce travail, après avoir rappelé quelques principes physiques de la thermoluminescence, on présente cette méthode de datation en mettant l'accent sur le mécanisme thermoluminescent dans une poterie. Ainsi la dose d'irradiation reçue par le matériau étant proportionnelle au temps écoulé depuis le 'zéro archéologique', il est possible de déterminer 'la dose archéologique' et d'en déduire l'âge de l'échantillon après avoir calculé la dose d'irradiation annuelle. La réalisation pratique d'un tel ensemble de mesure est cependant très ardue. Dans un prochain article, E. A. Decamps et A. Roman montreront des résultats relatifs à la thermoluminescence d'échantillons de quartz naturels, purs et dopés et la mise au point d'une nouvelle méthode de datation. Desde 1953, muchos investigadores se han interesado en la datación por termoluminiscencia de minerales antiguamente quemados o cocidos. Dentro de este trabajo, luego de haber recordado algunos principios físicos de la termoluminiscencia, se presenta este método de datación poniendo mayor atención en el mecanismo termoluminescente en una vasija de metal o de barro. Siendo proporcional la dosis de irradiación recibida al tiempo transcurrido desde el 'cero arqueológico', es posible determinar 'la dosis arqueológica', y deducir la edad de la muestra luego de haber calculado la dosis de irradiación anual. La realización práctica de un trabajo de tal dimensión es sin embargo muy ardua. En un próximo artículo, E. A. Decamps y A. Román presentarán los resultados relativos a la termoluminiscencia de muestras de cuarzo naturales, puras y dopadas y la elaboración de un nuevo método de datación. Since 1953, a number of scientists have been concerned with the use of thermoluminescence for the dating of burned or fired minerals

  9. The ParB-parS Chromosome Segregation System Modulates Competence Development in Streptococcus pneumoniae

    NARCIS (Netherlands)

    Attaiech, Laetitia; Minnen, Anita; Kjos, Morten; Gruber, Stephan; Veening, Jan-Willem

    UNLABELLED: ParB proteins bind centromere-like DNA sequences called parS sites and are involved in plasmid and chromosome segregation in bacteria. We previously showed that the opportunistic human pathogen Streptococcus pneumoniae contains four parS sequences located close to the origin of

  10. Türkçe Öğretmenlerinin Okuma Yöntem-Tekniklerini ve Araç-Gereçlerini Kullanma Durumları The Using Conditions Of In Reading Methods-Techniques And Materials Of The Turkish Teachers'

    Directory of Open Access Journals (Sweden)

    Fulya TOPÇUOĞLU ÜNAL

    2013-07-01

    questions methods are almost at the same rate; reading methods such as verbal choir, reading theatre and memorizing are used less frequently.Additionally, teachers use the teachers’ guidebook with 93% and the course book with 92%. Usage rates of spelling dictionary and dictionaries are very close to each other between the rates of 88-83%; and use of extracurricular reading books remains at 75%. Meanwhile, it was identified that participants do not use the technology in the reading field of Turkish language course, as the rate of use is marked at 67%.Silent and oral reading method emerges as the most used methods for male participants. While oral reading is also the most used method for female participants, association with text emerges as the second most used method. Reading Theater and memorizing methods are the two least used methods for both male and female participants. Türkçe dersi çok yönlü bir derstir. Bu bakımdan, bu dersle ilgili çalışmalar sırasında birden çok değişik yöntem ve tekniğe başvurulması hem doğal, hem de zorunludur. Türkçe Dersi Öğretim Programı’nda okuma, diğer becerilerin geliştirilmesi için temel olarak görülmüştür.Öğrenmenin etkili ve kalıcı olabilmesi için, öğrendiklerimiz birçok duyumuza hitap etmelidir. Bu anlamda okuma alanındaki yöntem-teknik ve araç-gereçler; analiz yapan, sorgulayan, sınıflayan, üreten bireyler olarak yetiştirilmemiz için kullanılmalıdır. Türkçe öğretimi, yalnızca dilsel metinlerle yürütülen bir süreç olmaktan çıkarılıp görsel, işitsel metinlerle de desteklenerek yürütülmelidir.Bu araştırmanın amacı, Türkçe öğretmenlerinin 7 ve 8. sınıf Türkçe öğretim programında yer alan okuma alanında kullanılması önerilen yöntem-teknikleri ve araç-gereçleri kullanma durumlarının belirlenmesidir. Araştırma tarama modelindedir. Araştırmanın örneklemi Bursa il merkezinde görev yapan 298 öğretmenden oluşmaktadır. Örnekleme y

  11. Benefits of Computer Assisted Translation to Information Managers and End-Users (L’Interet de la Traduction Assistee par Ordinateur Pour les Responsables de Centres d’Information et Pour Les Utilisateurs Finaux)

    Science.gov (United States)

    1990-06-01

    et Les Lieu de s’ignorer oti de se conctirrencer, on transpozitions utiLes dans La langue de verra sloperer dans Les entreprises des b’utitisateur... performants , avec capacitd d’apprentsssage, permet tine transition dventuelle entre systbmes, ou encore la taoisation de textes pour lesquels des disquettes...charge ou des 6tudes sp6ciales soient entreprises sur les proc6d~s de 1 l6coulement de l’information et des technologies sp6cifiques telles que la CD

  12. CONFERENCE Proceedings of the computer Aided System Design and Simulation (50th) Held in Cesme/Ismir, Turkey on 22-25 May 1990 (Systeme de Conception Aide par Ordinateur et Simulation)

    Science.gov (United States)

    1990-05-01

    bord . -non ~ ~ ~ ... p.trbo du pioaeie a la capacit6 donn~e A ’algorithme de g~rer partiellement les ordres cycliqucs qui lui permettent d𔄀quilibrer...principales caractdristiques de l ’dcartomdtre sont prdsent~es dans le tableau 1 pour les deux types de d~tecteurs envisag~s. D~tecteur Temps de P~riode...sentdes dans le tableau 2 pour les deux types de d6tecteur, avec une quantification de 1𔄀cartom~trie de * de pixel. D~tecteur Quanti

  13. Chemical lumping of mechanisms generated by computer. Application to the modelling of normal butane oxidation; Globalisation chimique de mecanismes generes par ordinateur. Application a la modelisation de l`oxydation du n-butane

    Energy Technology Data Exchange (ETDEWEB)

    Bounaceur, R.; Warth, V.; Glaude, P.A.; Battin-Leclerc, F.; Scacchi, G.; Come, G.M. [Nancy-1 Univ., 54 (France); Faravelli, T.; Ranzi, E. [Politecnico di Milano, Milan (Italy)

    1996-09-01

    There is an increasing need for the development of well validated and reliable models to represent the combustion phenomena in spark ignited engines, in order to formulate gasolines which present optimal octane number properties and which lead to a minimal pollutants formation. These models require the development of chemical mechanisms, to reproduce the combustion reactions, which can be embedded in three dimensional computational fluid dynamic codes in order to be employed to model the reactive flows found in real combustion devices. At the moment, a complete mechanism for modelling the combustion of organic compounds includes several thousands of elementary reactions and thus cannot be incorporated in such codes due to the present limitations of computer hardware. This lead to an urgent need of techniques to reduce the size of complex chemical mechanisms. This paper describes a technique which permits to drastically reduce comprehensive primary mechanisms which can be obtained by computer aided design in the case of the gas-phase oxidation of alkanes. This procedures has been tested by reducing a primary mechanism which has been automatically generated in the case of the normal-butane oxidation by the software EXGAS which is developed in Nancy. The reduced mechanism thus obtained permits to obtain results very close to those computed by using the complete mechanism in the case of the modelling of the normal-butane oxidation both at low temperature between 554 and 737 K, in the negative temperature coefficient field, and at higher temperature at 937 K. In fact, the normal-butane oxidation is rather an academic example to test this method as the global number of reaction is only reduced from 1149 reactions to 971 reactions with the CO-C2 reaction base containing 781 reactions. This method will be really useful to reduce bigger mechanism contains 2141 reactions and could be reduced to around 150 reactions. The further problem will also to be able to reduce the CO-C2 reaction base. (authors) 18 refs.

  14. Le Clos de Vougeot : relevés assistés par ordinateur et étude du bâti d’un cellier monastique. Premiers résultats

    Directory of Open Access Journals (Sweden)

    Marion Foucher

    2008-07-01

    Full Text Available Malgré sa renommée et l’excellent état de conservation des bâtiments, le cellier du Clos de Vougeot a fait l’objet d’un nombre limité d’études récentes et seules les charpentes et pressoirs ont donné lieu à une analyse en dendrochronologie. Dans ce contexte de recherche, une première approche du bâti du cellier, réalisée au cours d’un stage de Master Pro Archéosciences à l’Université de Bourgogne, m’a permis d’aborder de nouvelles problématiques, puisqu’elles s’intéressent essentiellement aux...

  15. L'alternance de code de deux enseignants de francais dans l'enseignement assiste par ordinateur de niveau debutant de langue seconde (Codeswitching in Two French as a Second Language Teachers, Beginning Level, in Computer Assisted Instruction).

    Science.gov (United States)

    Taylor, Alan M.

    2002-01-01

    Investigates the code switching of two French teachers in a computer-assisted language learning (CALL) environment. Highlights the importance of the social dynamic and technical aspects of teachers' codeswitching behaviors. (Author/VWL)

  16. L'enseignement du francais par ordinateur: Les programmes conversationnels au Cafe (Cours autodidactique de francais ecrit) [Teaching French by Computer: Conversational Programs in "Cafe" (Self-instructional Course in Written French)].

    Science.gov (United States)

    Landriault, Bernard; Connolly, Guy

    1980-01-01

    Computer technology has been used to develop "Cafe," a self-instructional course in written French communication, which is offered to the general public by the University of Montreal. The course consists of three workbooks containing 1200 items dealing with vocabulary, spelling, punctuation, agreements, morphology, syntax, and fine points of…

  17. Les représentations des enseignants quant à leurs profils de compétences relatives à l’ordinateur : vers une théorie des TIC en éducation

    OpenAIRE

    François Desjardins

    2005-01-01

    Depuis plusieurs années, dans la littérature, on peut sentir un besoin de préciser l’ensemble de connaissances et de compétences relatives aux ordinateurs nécessaires à l’enseignement et à l’apprentissage. Dans ce contexte, cette recherche vise à développer un modèle global qui permettrait de classer à la fois les outils, leurs usages, leurs incidences ainsi que les connaissances et compétences impliquées dans l’intégration des TIC en éducation de façon à pouvoir comprendre les diverses relat...

  18. Par Pond Fish, Water, and Sediment Chemistry

    Energy Technology Data Exchange (ETDEWEB)

    Paller, M.H. [Westinghouse Savannah River Company, AIKEN, SC (United States); Wike, L.D.

    1996-06-01

    The objectives of this report are to describe the Par Pond fish community and the impact of the drawdown and refill on the community, describe contaminant levels in Par Pond fish, sediments, and water and indicate how contaminant concentrations and distributions were affected by the drawdown and refill, and predict possible effects of future water level fluctuations in Par Pond.

  19. Par Pond Fish, Water, and Sediment Chemistry

    International Nuclear Information System (INIS)

    Paller, M.H.; Wike, L.D.

    1996-06-01

    The objectives of this report are to describe the Par Pond fish community and the impact of the drawdown and refill on the community, describe contaminant levels in Par Pond fish, sediments, and water and indicate how contaminant concentrations and distributions were affected by the drawdown and refill, and predict possible effects of future water level fluctuations in Par Pond

  20. Recherche documentaire par titrage automatique

    OpenAIRE

    Lopez , Cédric; Prince , Violaine; Roche , Mathieu

    2011-01-01

    Nous proposons dans cet article un système facilitant la recherche d'information dans un ensemble de documents textuels, basé sur le titrage (et sous-titrage) automatique. Ce dernier peut se révéler crucial, par exemple, dans le cadre de la problématique de l'accessibilité des pages web (norme W3C). Notre processus de titrage automatique consiste à extraire des syntagmes nominaux pertinents dans les textes, pouvant constituer des titres ou sous-titres candidats. Une approche originale combina...

  1. SECHAGE DE PRODUITS GRANULAIRES PAR DESHYDRATATION PAR DETENTES SUCCESSIVES (DDS)

    OpenAIRE

    Abdulla , Galal; Mellouk , Hamid; Belghit , Abdelhamid; Allaf , Karim

    2009-01-01

    International audience; Dans cette étude, nous avons évalué les performances d'un nouveau procédé de séchage dans le cas du liège en granulés. Ce procédé (La déshydratation par détentes successives : DDS) consiste à soumettre le matériau liège dans une chambre hermétique aux variations cycliques de la pression. Chaque cycle est composé d'une compression et d'une décompression. La phase de compression est réalisée en injectant de l'air comprimé à température ambiante provenant d'un compresseur...

  2. La preuve par le nombre

    Directory of Open Access Journals (Sweden)

    Hélène Verdier

    2012-04-01

    Full Text Available S’il en était besoin, la question des usages et de la finalité des résultats de l’inventaire général pourrait être abordée par le nombre : nombre d’œuvres répertoriées, de communes inventoriées, de clichés photographiques réalisés, de dossiers, de consultations des notices dans les bases de données… Les additions aujourd’hui sont éloquentes, mais elles laissent dans l’ombre le rôle de l’inventaire qui, en mettant en œuvre une démarche systématique de connaissance, participe à l’ identificatio...

  3. Par Pond vegetation status Summer 1995 -- Summary

    International Nuclear Information System (INIS)

    Mackey, H.E. Jr.; Riley, R.S.

    1996-01-01

    The water level of Par Pond was lowered approximately 20 feet in mid-1991 in order to protect downstream residents from possible dam failure suggested by subsidence on the downstream slope of the dam and to repair the dam. This lowering exposed both emergent and nonemergent macrophyte beds to drying conditions resulting in extensive losses. A survey of the newly emergent, shoreline aquatic plant communities of Par Pond began in June 1995, three months after the refilling of Par Pond to approximately 200 feet above mean sea level. These surveys continued in July, September, and late October, 1995. Communities similar to the pre-drawdown, Par Pond aquatic plant communities are becoming re-established. Emergent beds of maidencane, lotus, waterlily, and watershield are extensive and well developed. Cattail occurrence continued to increase during the summer, but large beds common to Par Pond prior to the drawdown have not formed. Estimates from SPOT HRV, remote sensing satellite data indicated that as much as 120 hectares of emergent wetlands vegetation may have been present along the Par Pond shoreline by early October, 1995. To track the continued development of macrophytes in Par Pond, future surveys throughout 1996 and 1997, along with the continued evaluation of satellite data to map the areal extent of the macrophyte beds of Par Pond, are planned

  4. Les représentations des enseignants quant à leurs profils de compétences relatives à l’ordinateur : vers une théorie des TIC en éducation

    Directory of Open Access Journals (Sweden)

    François Desjardins

    2005-02-01

    Full Text Available Depuis plusieurs années, dans la littérature, on peut sentir un besoin de préciser l’ensemble de connaissances et de compétences relatives aux ordinateurs nécessaires à l’enseignement et à l’apprentissage. Dans ce contexte, cette recherche vise à développer un modèle global qui permettrait de classer à la fois les outils, leurs usages, leurs incidences ainsi que les connaissances et compétences impliquées dans l’intégration des TIC en éducation de façon à pouvoir comprendre les diverses relations qui existent entre chacune de ces composantes. Une première opérationnalisation de ce modèle a donné lieu au développement d’un instrument permettant de recueillir les représentations des enseignants quant à leurs compétences. Cet article présente le modèle élaboré, le questionnaire qui en a découlé et les résultats des premières analyses statistiques des profils recueillis auprès de plus de 600 enseignants francophones de l’Ontario.

  5. Regulatory cross-talk in the double par locus of plasmid pB171

    DEFF Research Database (Denmark)

    Ringgaard, Simon; Ebersbach, Gitte; Borch, Jonas

    2007-01-01

    The double par locus of Escherichia coli virulence factor pB171 consists of two adjacent and oppositely oriented par loci of different types, called par1 and par2. par1 encodes an actin ATPase (ParM), and par2 encodes an oscillating, MinD-like ATPase (ParA). The par loci share a central cis...

  6. ¡París!

    Directory of Open Access Journals (Sweden)

    Beatriz Caballero

    2003-01-01

    Full Text Available El día no le alcanzaba para caminarlo. Conocía cada puente, cada calle,plaza, museo, rincón, iglesia, café, y la mesa con el mejor ángulo para mirar siempre una iglesia, ojalá Saint-Germain-des-Pres, o Notre-Dame. Siempre contaba la impresión que le había causado a Bolívar ver allí cuando el papa coronó a Napoleón. Él se iba para la oficina todos los días, Luis a un taller a pintar, Antonio a estudiar ciencias políticas, yo al colegio y mamá hacía las cosas prácticas. Aprendíamos francés todos al tiempo y por la noche nos contábamos lo nuevo que cada uno había aprendido. Mamá después, cuando ya se quería volver, decía que París nos había maleado a todos. Estaba en pleno furor el cine francés de la "nueva ola", pero ella sólo me llevaba a ver películas de vaqueros pues no se fiaba de la clasificación de los periódicos.

  7. étude par AFM dynamique.

    African Journals Online (AJOL)

    user

    Rwanda Journal Volume 20, Series C, 2011 : Mathematical Sciences, Engineering and Technology. 53. - un tube piézoélectrique assurant le déplacement relatif, dans les trois directions x, y, z de l'espace, de la pointe par rapport à l'échantillon. L'acquisition des données s'effectue par asservissement de la position de la.

  8. C9.A/14 steelwork joints de poutres par plaque frontale : assemblages par gousset

    CERN Document Server

    2015-01-01

    Les Tables de résistances ultimes des assemblages boulonnés par plaque frontale et par gousset, complétées par une description des modèles de calcul et des exemples d’application, ont pour but de faciliter la tâche de l'ingénieur et du constructeur. Cette première partie C9.A/14 contient les chapitres suivants: - Joints de poutres par plaque frontale en acier S235 et S355 - Assemblages par gousset en acier S235 et S355 Les Tables contiennent des données relatives à la géométrie ainsi que les valeurs de calcul correspondantes des résistances ultimes des assemblages ; elles remplacent le chapitre « Assemblages par plaques frontales et boulons HR » des anciennes Tables C9.1 de 1983 / 2002. Le calcul de ces assemblages par plaque frontale est basé sur les hypothèses du modèle de la méthode des composants décrite dans la norme SN EN 1993-1-8. Les vérifications sont effectuées selon la norme SIA 263:2013. Les assemblages par gousset remplacent les assemblages par double cornière, (telle...

  9. Analysis methods of neutrons induced resonances in the transmission experiments by time-of-flight and automation of these methods on IBM 7094 II computer; Methode d'analyse des resonances induites par les neutrons dans les experiences de transmission par temps-de-vol et automatisation de ces methodes sur ordinateur IBM-7094 II

    Energy Technology Data Exchange (ETDEWEB)

    Corge, C

    1967-07-01

    The neutron induced resonances analysis aims to determine the neutrons characteristics, leading to the excitation energies, de-excitation probabilities by gamma radiation emission, by neutron emission or by fission, their spin, their parity... This document describes the methods developed, or adapted, the calculation schemes and the algorithms implemented to realize such analysis on a computer, from data obtained during time-of-flight experiments on the linear accelerator of Saclay. (A.L.B.)

  10. « Dans une société sans livre, pourquoi commencer par les livres ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    22 déc. 2010 ... Christopher Senono, un jeune homme qui avait perdu ses sept frères et sœurs dans le génocide, voulait savoir en quoi ces ordinateurs pouvaient aider son entreprise. Un appareil photo numérique, une imprimante couleur portable — et la première enseigne de l'ère informatique prenait forme à Nakaseke ...

  11. Protease-activated receptor (PAR)-2 is required for PAR-1 signalling in pulmonary fibrosis

    NARCIS (Netherlands)

    Lin, Cong; von der Thüsen, Jan; Daalhuisen, Joost; ten Brink, Marieke; Crestani, Bruno; van der Poll, Tom; Borensztajn, Keren; Spek, C. Arnold

    2015-01-01

    Idiopathic pulmonary fibrosis is the most devastating diffuse fibrosing lung disease of unknown aetiology. Compelling evidence suggests that both protease-activated receptor (PAR)-1 and PAR-2 participate in the development of pulmonary fibrosis. Previous studies have shown that bleomycin-induced

  12. Parálisis criptogénica del III par craneal

    Directory of Open Access Journals (Sweden)

    Albia Josefina Pozo Alonso

    Full Text Available La parálisis aislada del tercer par craneal no es frecuente en los niños. Entre las causas que la originan se encuentran las congénitas, traumáticas, infecciosas, tumorales, vasculares, tóxicas y desmielinizantes. Se presenta un paciente de 3 años de edad con el diagnóstico de una oftalmoplejía aguda dolorosa del tercer par craneal, cuya etiología no se pudo demostrar. El cuadro clínico desapareció de forma espontánea y no ha presentado recurrencias después de 3 años de seguimiento. Se concluye que ante un paciente con parálisis del tercer par craneal es necesario realizar una exhaustiva evaluación con el propósito de precisar las diversas causas que la provocan.

  13. Direct digital control of furnaces irradiated in nuclear reactors; Surveillance et regulation multiplexee par calculateur numerique de fours irradies

    Energy Technology Data Exchange (ETDEWEB)

    Joumard, R. [Commissariat a l' Energie Atomique, Grenoble (France). Centre d' Etudes Nucleaires

    1969-07-01

    An experimental direct digital control system has been realised in the 'C.E.N.G.', in order to verify that a computer makes easier the control of the experiments done in the nuclear reactors and to solve the theoretical and technical difficulties. The regulation is applied to thermal processes. The sampled data systems theory permits to choose the type of an efficient and simple digital compensator, and to establish a diagram which gives the values of the correcting parameters (obtained by minimizing the difference between the output and the input when perturbations occur). The programme execute, in simultaneity, supervision and regulation. Complex possibilities of printing out measures and alarms existed. The computer works out an incremental correction which makes step motors to turn. These motors act on the heating organs. The theoretical values and answers have been confirmed. The accuracy was limited essentially by the input quantification (1/1000 th). The comfort of such a system has been noticeable. (author) [French] Une installation de controle numerique direct fut realisee a titre experimental au C.E.N.G pour verifier qu'un ordinateur rendait plus aisee l'exploitation des experiences faites en pile nucleaire et pour degager les difficultes theoriques et techniques. La regulation s'applique a des processus thermiques. La theorie des systemes echantillonnes a permis de choisir un type de correcteur numerique simple et efficace et d'etablir un abaque qui donne les valeurs des parametres correcteurs minimisant les ecarts enregistres entre la reponse et la consigne en presence de perturbations. Le programme effectuait simultanement de la surveillance et de la regulation. Une restitution complexe des informations et des alarmes sur machine a ecrire etait possible. Le calculateur elaborait une correction incrementielle qui faisait tourner des moteurs pas a pas, lesquels commandaient les organes de puissance de chauffage. Les valeurs

  14. Le stockage thermique par chaleur latente

    OpenAIRE

    Martin, F.; Nicolas, Jacques

    1988-01-01

    L'article présente le principe du stockage d'énergie par transformation de phase ainsi que les matériaux employés (composés organiques, sels hydratés et matériaux à transformation solide-solide) et les différents types d'échangeurs. Peer reviewed

  15. Coinfection pulmonaire par pneumocystis jirovecii et pseudomonas ...

    African Journals Online (AJOL)

    Sous traitement, l'évolution a été favorable. Les coinfections morbides sont relativement fréquentes chez les patients vivant avec le VIH. Devant une symptomatologie respiratoire du sujet vivant avec le VIH, il faut savoir rechercher en plus du Bacille de Koch, Pneumocystis jirovecii et Pseudomonas aeruginosa par un ...

  16. The structure of para-toluidine by X-ray and neutron diffraction; Etude de la structure de la para-toluidine par la diffraction des rayons X et des neutrons

    Energy Technology Data Exchange (ETDEWEB)

    Bertinotti, A.L. [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1965-12-01

    The crystal and molecular structure of para-toluidine has been solved by X-ray and neutron diffraction counter techniques. The molecules are arranged in the form of infinite chains in the crystal, each molecule being linked to two neighbours by hydrogen bonds. The presence of the H bonds makes clear the difference in the melting points between para-toluidine and benzene hydrocarbons of related symmetry and molecular weight. Their direction accounts for the (001) cleavage and the growth anisotropy of crystals from supersaturated vapour phase. A structure-seeking method by computer has been elaborated, using lattice energy calculations applied to molecules treated as rigid bodies and making use of a simplex method for function minimization without calculation of derivatives. The way the available information is handled allows to increase the range of convergence, as shown in the case of para-toluidine. (author) [French] La structure cristalline et moleculaire de la para-toluidine a ete resolue a l'aide de la diffraction des rayons X et des neutrons. L'analyse a revele que la structure presentait un encha ement particulier des molecules, liees entre elles par des ponts hydrogene. La presence des liaisons rend compte de l'elevation du point de fusion de la para-toluidine par rapport a celui des carbures benzeniques de symetrie et de poids moleculaires voisins. La direction des liaisons explique le clivage facile (001) des cristaux obtenus par fusion et l'anisotropie de croissance des cristaux en phase vapeur. Une methode de recherche de structures par ordinateur a ete elaboree, faisant usage du concept d'energie reticulaire applique aux molecules considerees comme rigides et faisant appel a une methode de simplexe pour la minimisation des fonctions sans calcul de derivees. La maniere dont est exploitee l'information disponible permet d'accro re, comme cela est montre dans le cas de la para-toluidine, l'etendue du domaine de

  17. Modélisation informatique de la production d’énergie renouvelable à partir de biogaz par transformation anaérobique dumélange de résidus d’agrumes et defumier de bovins

    Directory of Open Access Journals (Sweden)

    Edwin Dario Cendales L.

    2014-03-01

    Full Text Available Dans cet article nous avons simulé par ordinateur le processus de digestion anaérobique d’un mélange homogénéisé de fumier bétail et de résidus d’agrumes afin d’évaluer la viabilité des énergies renouvelables à partir de la transformation des déchets. Sur la base des résultats obtenus et grâce au développement de la phase expérimentale lors de laquelle étaient mesurées de façon périodiques les variables de contrôle du processus de biodégradation anaérobique tels que le pH, l’alcalinité, la demande chimique en oxygène (total et soluble, nous avons établi les performances des paramètres du processus et déterminé des valeurs pour la comparaison entre résultats expérimentaux et résultats informatiques. Nous avons en outre réalisé une simulation du processus de digestion anaérobique dans des conditions similaires à celles précédemment établis par d’autres essais expérimentaux à travers la mise en oeuvre du modèle ADM-1. Grâce aux résultats obtenus par le biais de simulations et mesures expérimentales, nous avons évalué la précision du modèle concernant les valeurs des mesures expérimentales. Un modèle simplifié pour l’évaluation de l’énergie produite par une installation à échelle réduite qui effectue le traitement anaérobique des résidus organiques a finalement été mis en place. Le modèle a montré qu’il existe au départ un déficit énergétique pour que le processus se réalise, mais une fois la production de biogaz enclenchée, le processus devient autonome et le système fournit une quantité croissante d’énergie disponible.

  18. PAR-TERRA directs homologous sex chromosome pairing.

    Science.gov (United States)

    Chu, Hsueh-Ping; Froberg, John E; Kesner, Barry; Oh, Hyun Jung; Ji, Fei; Sadreyev, Ruslan; Pinter, Stefan F; Lee, Jeannie T

    2017-08-01

    In mammals, homologous chromosomes rarely pair outside meiosis. One exception is the X chromosome, which transiently pairs during X-chromosome inactivation (XCI). How two chromosomes find each other in 3D space is not known. Here, we reveal a required interaction between the X-inactivation center (Xic) and the telomere in mouse embryonic stem (ES) cells. The subtelomeric, pseudoautosomal regions (PARs) of the two sex chromosomes (X and Y) also undergo pairing in both female and male cells. PARs transcribe a class of telomeric RNA, dubbed PAR-TERRA, which accounts for a vast majority of all TERRA transcripts. PAR-TERRA binds throughout the genome, including to the PAR and Xic. During X-chromosome pairing, PAR-TERRA anchors the Xic to the PAR, creating a 'tetrad' of pairwise homologous interactions (Xic-Xic, PAR-PAR, and Xic-PAR). Xic pairing occurs within the tetrad. Depleting PAR-TERRA abrogates pairing and blocks initiation of XCI, whereas autosomal PAR-TERRA induces ectopic pairing. We propose a 'constrained diffusion model' in which PAR-TERRA creates an interaction hub to guide Xic homology searching during XCI.

  19. Centromere pairing by a plasmid-encoded type I ParB protein

    DEFF Research Database (Denmark)

    Ringgaard, Simon; Löwe, Jan; Gerdes, Kenn

    2007-01-01

    The par2 locus of Escherichia coli plasmid pB171 encodes two trans-acting proteins, ParA and ParB, and two cis-acting sites, parC1 and parC2, to which ParB binds cooperatively. ParA is related to MinD and oscillates in helical structures and thereby positions ParB/parC-carrying plasmids regularly...

  20. Pars plana Baerveldt tube insertion with pars plana vitrectomy for refractory glaucoma

    Directory of Open Access Journals (Sweden)

    Anton M Kolomeyer

    2012-01-01

    Conclusions: Pars plana Baerveldt tube implantation with PPV can preserve vision, reduce IOP, and decrease the number of glaucoma medications necessary to achieve target IOP in patients with recalcitrant glaucoma.

  1. SAFARI 2000 PAR Measurements, Kalahari Transect, Botswana, Wet Season 2000

    Data.gov (United States)

    National Aeronautics and Space Administration — ABSTRACT: Ceptometer data from a Decagon AccuPAR (Model PAR-80) were collected at four sites in Botswana during the SAFARI 2000 Kalahari Transect Wet Season Campaign...

  2. Copenhagen uPAR prostate cancer (CuPCa) database

    DEFF Research Database (Denmark)

    Lippert, Solvej; Berg, Kasper D; Høyer-Hansen, Gunilla

    2016-01-01

    AIM: Urokinase plasminogen activator receptor (uPAR) plays a central role during cancer invasion by facilitating pericellular proteolysis. We initiated the prospective 'Copenhagen uPAR Prostate Cancer' study to investigate the significance of uPAR levels in prostate cancer (PCa) patients. METHODS......: Plasma samples and clinical data from patients with newly diagnosed PCa have been collected prospectively. The uPAR forms have been measured in plasma using time-resolved fluorescence immunoassays. RESULTS: The level of intact uPAR(I-III) did not differ. Plasma uPAR(I-III) + uPAR(II-III) levels and u......PAR(I) levels were significantly higher in hormone-naive and castrate-resistant patients compared with patients with localized disease (both: p PCa....

  3. SAFARI 2000 PAR Measurements, Kalahari Transect, Botswana, Wet Season 2000

    Data.gov (United States)

    National Aeronautics and Space Administration — Ceptometer data from a Decagon AccuPAR (Model PAR-80) were collected at four sites in Botswana during the SAFARI 2000 Kalahari Transect Wet Season Campaign (March,...

  4. Het die reformasie die leer gered en aanbidding verloor? | Spoelstra ...

    African Journals Online (AJOL)

    Little information is available on the relation between doctrine and liturgy during and after the Reformation. The concept “doctrine” relates to what is, since Emanuel Kant, labelled as theory and “liturgy” refers to practice as if these concepts were not related. This article investigates the validity of this perception. It asserts that ...

  5. Nyankomne asylansøgeres helbredsstatus og traumatiseringsgrad--sekundaerpublikation

    DEFF Research Database (Denmark)

    Masmas, Tania Nicole; Møller, Eva; Buhmann, Caecilie

    2010-01-01

    An unknown number of asylum seekers arriving in Denmark have been exposed to torture. Amnesty International's Danish Medical Group examined 142 asylum seekers, of whom 45% had been exposed to torture. Physical and psychological symptoms were 2-3 times as frequent among torture survivors as among...... non-tortured asylum seekers. Among the torture survivors, 63% fulfilled the criteria of post-traumatic stress disorder, 58% had objective psychological findings, and 42% had torture-related scars. Identification of torture survivors is important in order to initiate the necessary medical treatment...

  6. Sygdom hos asylansøgere opdages for sent

    DEFF Research Database (Denmark)

    Eiset, Andreas Halgreen; Wejse, Christian

    2016-01-01

    Der er behov for bedre indsigt i, hvilke sygdomme den enkelte asylansøger kæmper med, og der er behov for at få klarhed over, hvilke helbredsrisici der introduceres i løbet af asylprocessen. Hvis vi ikke sikrer dette, bryder vi med princippet om at tilstræbe forebyggelse og tidlig behandling....

  7. Selvmordsforsøgeres kontakt til den primaere sundhedssektor

    DEFF Research Database (Denmark)

    Jensen, Børge Frank; Christiansen, Erik

    2005-01-01

    We examined suicide attempters' use of health insurance services as part of an effort to prevent suicidal behaviour.......We examined suicide attempters' use of health insurance services as part of an effort to prevent suicidal behaviour....

  8. 08 Richardson - On-farm demonstrations - gereed vir publik…

    African Journals Online (AJOL)

    lynette

    Demonstrations of new or innovative practices carried out on actual farms have long been a key hallmark of program delivery and teaching in extension work. Such demonstrations led to the founding of the extension system in the United States about a century ago. These on- farm demonstrations gained the confidence of ...

  9. The inflammatory marker suPAR after cardiac arrest

    DEFF Research Database (Denmark)

    Rundgren, Malin; Lyngbaek, Stig; Fisker, Helle

    2015-01-01

    . This pilot study aimed at investigating suPAR levels in relation to outcome after CA and mild induced hypothermia. METHODS: suPAR levels were measured at 6, 36, and 72 hours in patients treated with hypothermia after CA. suPAR levels were analyzed in relation to survival after 6 months. Receiver operating...

  10. Molecular Mechanisms of Par-4-Induced Apoptosis in Prostate Cancer

    National Research Council Canada - National Science Library

    Ladias, John A

    2007-01-01

    .... Phosphorylation of Par-4 by Akt1 results in inhibition of apoptosis. To obtain insights into the mechanisms of Par-4 selective killing of prostate cancer cells, we expressed the human Par-4 SAC domain in bacteria and purified it to homogeneity...

  11. Macrophage Migration Inhibitory Factor Mediates PAR-Induced Bladder Pain.

    Directory of Open Access Journals (Sweden)

    Dimitrios E Kouzoukas

    Full Text Available Macrophage migration inhibitory factor (MIF, a pro-inflammatory cytokine, is constitutively expressed in urothelial cells that also express protease-activated receptors (PAR. Urothelial PAR1 receptors were shown to mediate bladder inflammation. We showed that PAR1 and PAR4 activator, thrombin, also mediates urothelial MIF release. We hypothesized that stimulation of urothelial PAR1 or PAR4 receptors elicits release of urothelial MIF that acts on MIF receptors in the urothelium to mediate bladder inflammation and pain. Thus, we examined the effect of activation of specific bladder PAR receptors on MIF release, bladder pain, micturition and histological changes.MIF release was measured in vitro after exposing immortalized human urothelial cells (UROtsa to PAR1 or PAR4 activating peptides (AP. Female C57BL/6 mice received intravesical PAR1- or PAR4-AP for one hour to determine: 1 bladder MIF release in vivo within one hour; 2 abdominal hypersensitivity (allodynia to von Frey filament stimulation 24 hours after treatment; 3 micturition parameters 24 hours after treatment; 4 histological changes in the bladder as a result of treatment; 5 changes in expression of bladder MIF and MIF receptors using real-time RT-PCR; 6 changes in urothelial MIF and MIF receptor, CXCR4, protein levels using quantitative immunofluorescence; 7 effect of MIF or CXCR4 antagonism.PAR1- or PAR4-AP triggered MIF release from both human urothelial cells in vitro and mouse urothelium in vivo. Twenty-four hours after intravesical PAR1- or PAR4-AP, we observed abdominal hypersensitivity in mice without changes in micturition or bladder histology. PAR4-AP was more effective and also increased expression of bladder MIF and urothelium MIF receptor, CXCR4. Bladder CXCR4 localized to the urothelium. Antagonizing MIF with ISO-1 eliminated PAR4- and reduced PAR1-induced hypersensitivity, while antagonizing CXCR4 with AMD3100 only partially prevented PAR4-induced hypersensitivity

  12. Deltagerinvolveret organisationsudvikling med PAR som metode

    DEFF Research Database (Denmark)

    Sparre, Mogens

    2017-01-01

    about the organization in an management group with a Participatory Action Research (PAR) case study? The article deals with a Phenomenological case study, where the researcher, with a PAR approach method, creates a research design with the purpose to influence the participant’s “Subjective perception......When a leader wants to initiate or influence some necessary changes in the organization, he must be aware of the fact that the subjects that form the organization create their own meaning about actions the manager wants implemented. This article confronts the assumption that people are by nature...... resistant to change. The quite widespread narrative of resistance to change, is believed to originate from the many top-down driven change projects implemented by the top management or/and external consultants. Is it possible to create a desired change in the form of the inter-subjective perception building...

  13. Les Brulures Chimiques Par Le Laurier Rose

    OpenAIRE

    Bakkali, H.; Ababou, M.; Nassim Sabah, T.; Moussaoui, A.; Ennouhi, A.; Fouadi, F.Z.; Siah, S.; Ihrai, H.

    2010-01-01

    Le laurier rose ou Nerium oleander est un arbuste qui pousse naturellement dans les régions méditerranéennes. Au Maroc on le trouve dans les lieux humides. Il est réputé par ses risques de toxicité systémique en cas d'empoisonnement à cause de la présence de deux alcaloïdes, surtout l'oléandrine. La littérature illustre des cas d'utilisation locale des feuilles de cette plante contre la gale, les hémorroïdes et les furoncles. Nous rapportons deux cas de brûlures chimiques par le laurier rose ...

  14. [Ambroise Paré in French literature].

    Science.gov (United States)

    Dumaitre, P

    1995-01-01

    The 16th century by its passionate side has been the favourite one of authors of historical novels in which among the heroes of "cloak and dagger stories" appears sometime Ambroise Paré. Alexandre Dumas (the father) has shown him at the court of Charles IX in La Reine Margot (1845) where he does not however play a great role. On the contrary, Balzac in Le Martyr calviniste (1842) has given him a capital part close to the dying François II, whom he intended to trepanize but had to give up this idea as a consequence of the opposition of the queen-mother Catherine de Médicis. In the present century, Robert Merle in Paris ma bonne ville (Fortune de France, 3, 1980) shows Paré at the time of the Saint Barthélemy.

  15. Calculation of the resonance frequency change for a cavity charged by a plasma with or without a static magnetic field; Calcul du glissement de la frequence de resonance d'une cavite chargee par un plasma en presence ou non d'un champ magnetique statique

    Energy Technology Data Exchange (ETDEWEB)

    Melin, G. [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires. Service de physique appliquee, service d' ionique generale, section d' etude des interractions onde-plasma

    1967-03-01

    In the mere case of a cold plasma with or without static magnetic field, are given two methods of calculation of resonance frequency shift and absorption in a cylindrical cavity crossed by a plasma column: 1. A perturbation method, already known and used for electronic density measurements is restated and its application is used for several high frequency cavity modes. 2. An exact method employing Maxwell's equations, which however necessitates a computer, is compared with the first one; it permits a determination of the validity limits of the perturbation method and to draw conclusions,. [French] On donne Dans le cas d'un plasma froid en presence ou non de champ magnetique statique deux methodes de calcul de la derive de frequence de resonance et de l'absorption dans une cavite cylindrique traversee par une colonne de plasma: 1. Une methode de perturbation deja connue et employee dans les mesures de densite eleetronique; on en rappelle le principe et on en fait l'application pour plusieurs modes de la cavite haute frequence. 2. Une methode rigoureuse a partir des equations de Maxwell, dont la resolution necessite l'emploi d'un ordinateur; cette methode comparee a la precedente permet d'en determiner les limites de validite et de tirer des conclusions. (auteur)

  16. Par Pond refill water quality sampling

    Energy Technology Data Exchange (ETDEWEB)

    Koch, J.W. II; Martin, F.D.; Westbury, H.M.

    1996-08-01

    This study was designed to document anoxia and its cause in the event that the anoxia caused a fish kill. However, no fish kill was observed during this study, and dissolved oxygen and nutrient concentrations generally remained within the range expected for southeastern reservoirs. Par Pond water quality monitoring will continue during the second summer after refill as the aquatic macrophytes become reestablished and nutrients in the sediments are released to the water column.

  17. Regulatory cross-talk in the double par locus of plasmid pB171

    DEFF Research Database (Denmark)

    Ringgaard, Simon; Ebersbach, Gitte; Borch, Jonas

    2007-01-01

    The double par locus of Escherichia coli virulence factor pB171 consists of two adjacent and oppositely oriented par loci of different types, called par1 and par2. par1 encodes an actin ATPase (ParM), and par2 encodes an oscillating, MinD-like ATPase (ParA). The par loci share a central cis-actin...... well with the observed transcriptional regulation of the par operons in vivo and in vitro. Integration host factor (IHF) was identified as a novel factor involved in par2-mediated plasmid partitioning....

  18. PAR1 antagonists inhibit thrombin-induced platelet activation whilst leaving the PAR4-mediated response intact.

    Science.gov (United States)

    Judge, Heather M; Jennings, Lisa K; Moliterno, David J; Hord, Edward; Ecob, Rosemary; Tricoci, Pierluigi; Rorick, Tyrus; Kotha, Jayaprakash; Storey, Robert F

    2015-01-01

    Thrombin-induced platelet activation is initiated by PAR1 and PAR4 receptors. Vorapaxar, a PAR1 antagonist, has been assessed in patients with acute coronary syndromes (ACS) and stable atherosclerotic disease in addition to standard-of-care treatment. In clinical trials, vorapaxar has been observed to reduce the frequency of ischaemic events in some subgroups though in others has increased the frequency of bleeding events. Among patients undergoing CABG surgery, which is associated with excess thrombin generation, bleeding was not increased. The aim of these studies was to investigate the effects of selective PAR1 antagonism on thrombin-induced platelet activation in patients receiving vorapaxar or placebo in the TRACER trial and to explore the roles of PAR1 and PAR4 in thrombin-induced platelet activation in healthy volunteers. ACS patients receiving vorapaxar or placebo in the TRACER trial were studied at baseline and 4 hours, 1 and 4 months during drug administration. Thrombin-induced calcium mobilisation in platelet-rich plasma was assessed by flow cytometry. In vitro studies were performed in healthy volunteers using the PAR1 antagonist SCH79797 or PAR4 receptor desensitisation. Vorapaxar treatment significantly inhibited thrombin-induced calcium mobilisation, leaving a residual, delayed response. These findings were consistent with calcium mobilisation mediated via the PAR4 receptor and were reproduced in vitro using SCH79797. PAR4 receptor desensitization, in combination with SCH79797, completely inhibited thrombin-induced calcium mobilisation confirming that the residual calcium mobilisation was mediated via PAR4. In conclusion vorapaxar selectively antagonises the PAR1-mediated component of thrombin-induced platelet activation, leaving the PAR4-mediated response intact, which may explain why vorapaxar is well tolerated in patients undergoing CABG surgery since higher thrombin levels in this setting may override the effects of PAR1 antagonism through PAR4

  19. Investigating the Benefits and Challenges of Using Laptop Computers in Higher Education Classrooms / Étude sur les avantages et les défis associés à l'utilisation d'ordinateurs portables dans les salles de classe d'enseignement supérieur

    Directory of Open Access Journals (Sweden)

    Robin Holding Kay

    2014-05-01

    Full Text Available The purpose of this study was to investigate the benefits and challenges using laptop computers (hereafter referred to as laptops inside and outside higher education classrooms. Quantitative and qualitative data were collected from 156 university students (54 males, 102 females enrolled in either education or communication studies. Benefits of using laptops in class were active note taking, particularly when instructors provided materials ahead of time, searching for academic resources, use of subject-specific software, communicating and sharing information with peers, and engaging with online interactive tools. Challenges of using laptops inside the class included surfing the web for personal reasons, social networking with peers and, to a lesser extent, entertainment in the form of watching video podcasts or playing games. Benefits were reported far more often than challenges inside the classroom. Benefits of using laptops outside of class included collaboration with peers, increased productivity, and conducting research. Challenges of using laptops outside of class included surfing the web for personal reasons, social networking, and entertainment. Benefits and challenges were reported equally often outside the classroom. More research needs to be conducted on the extent to which distractions impede learning and productivity inside and outside the class. Cette étude avait pour but d’examiner les avantages et les défis associés à l'utilisation d’ordinateurs portables à l'intérieur et à l'extérieur des salles de classe d’enseignement supérieur. Des données quantitatives et qualitatives ont été recueillies auprès de 156 étudiants universitaires (54 hommes, 102 femmes inscrits dans des programmes d’éducation ou de communication. Les avantages de l'utilisation d’ordinateurs portables en classe incluaient la prise active de notes, en particulier lorsque les instructeurs fournissaient la documentation à l'avance, la

  20. Evaluation théorique de l'effet d'arête d'eau sur la production par puits horizontaux Theoretical Evaluation of Effect of Water Cresting on Production by Horizontal Wells

    Directory of Open Access Journals (Sweden)

    Giger F.

    2006-11-01

    Full Text Available L'effet de la formation d'un cône d'eau (water-coning est un phénomène fréquemment rencontré, dont l'apparition lors de l'exploitation d'un gisement d'huile comportant une surface de contact huile-eau près des puits, introduit des contraintes qui peuvent être déterminantes quant au rythme de production du champ. Dans le cadre de l'étude des motivations pour le forage horizontal menée sous l'aspect gisement , parallèlemenl aux simulations sur ordinateurs au moyen de modèles numériques, il est apparu intéressant d'évaluer la formation de l'effet d'arête d'eau et de déterminer le débit critique par la voie analytique. Cet article reprend la méthode de l'hodographe déjà appliquée à ce problème par D. A. Efros. Elle permet d'effectuer l'étude de la forme de l'arête à l'approche du régime critique. Une méthode de résolution pratique de ces problèmes par abaques est proposée. Water coning is a frequently-encountered phenomenon whose appearance, during production from an oil field having an oil-water contact surface near the wells, creates constraints that may be determinant concerning the rate at which the field is produced. As part of research on motivations for horizontal drilling from the standpoint of reservoir engineering, at the same time as computer simulations using numerical models, it appeared interesting to evaluate what effect a water cresting would have and to determine the critical flow rate by an analytic method. This article takes up the hodograph method already applied to the problem by D. A. Efros. It investigates the shape of the crest when approaching the critical regime. A method is proposed for the practical solution of such problems by charts.

  1. Modifier le cadre participatif pour résoudre un problème client : exemples d’ajustement opéré par les professionnels dans les interactions en centre d’appels

    Directory of Open Access Journals (Sweden)

    Colón De Carvajal Isabel

    2012-07-01

    Full Text Available Si, dans les interactions de service en centre d’appels, la conversation principale est celle engagée entre l’appelant et l’appelé, une multitude d’autres interactions caractérise le travail des opérateurs. Cet article présente une étude linguistique sur les interactions entre les opérateurs du centre d’appels LocBike, qui propose l’accès à des vélos en libre service dans une grande ville française, et les clients, qui empruntent ces vélos et appellent le centre en cas de problèmes. Ces interactions ont la particularité d’être menées autour d’objets technologiques, afin d’interagir avec le client et traiter son dossier. L’accès à cet environnement d’interactions téléphoniques médiées par ordinateur permet d’analyser la résolution du problème client du point de vue de l’opérateur, et d’observer que ce travail se réalise parfois en collaboration avec son collègue co-présent dans son environnement immédiat. Les professionnels opèrent alors des ajustements par rapport au dispositif de communication, ou s’ajustent eux-mêmes à ce dispositif, pendant l’interaction principale avec le client, ce qui tend à modifier le cadre participatif. L’objectif de notre travail est d’analyser les pratiques des professionnels lors de modifications du cadre participatif, et ce, dans le but de résoudre un problème client. A travers des exemples de collaboration, nous étudierons les formes d’ajustement que les professionnels mettent en place par rapport au dispositif de communication, modifiant ainsi temporairement le cadre participatif.

  2. Regulatory cross-talk in the double par locus of plasmid pB171

    DEFF Research Database (Denmark)

    Ringgaard, Simon; Ebersbach, Gitte; Borch, Jonas

    2007-01-01

    -acting region of approximately 200 bp, called parC1, located between the two par loci. An additional cis-acting region, parC2, is located downstream of the parAB operon of par2. Here we show that ParR of par1 and ParB of par2 bind cooperatively to unrelated sets of direct repeats in parC1 to form the cognate...... partition and promoter repression complexes. Surprisingly, ParB repressed transcription of the noncognate par operon, indicating cross-talk and possibly epistasis between the two systems. The par promoters, P1 and P2, affected each other negatively. The DNA binding activities of ParR and ParB correlated...

  3. Ordinateur et communication (Computer and Communication).

    Science.gov (United States)

    Mangenot, Francois

    1994-01-01

    Because use of computers in second-language classrooms may tend to decrease interpersonal interaction, and therefore communication, ways to promote interaction are offered. These include small group computer projects, and suggestions are made for use with various computer functions and features: tutorials, word processing, voice recording,…

  4. Accouchement par forceps: indications et pronostic materno-foetal ...

    African Journals Online (AJOL)

    L'accouchement par voie basse, peut être parfois compromis par des facteurs maternels, foetaux ou materno-foetaux nécessitant des moyens thérapeutiques comme le forceps pour achever l'accouchement par voie naturelle. Le forceps, une méthode qui n'est pas sans risque pour la mère et le nouveau-né. Nous avons ...

  5. The urokinase receptor (uPAR) and the uPAR-associated protein (uPARAP/Endo180)

    DEFF Research Database (Denmark)

    Behrendt, Niels

    2004-01-01

    processes involve a highly organized interplay between proteases and their cellular binding sites as well as specific substrates and internalization receptors. This review article is focused on two components, the urokinase plasminogen activator receptor (uPAR) and the uPAR-associated protein (uPARAP, also...... designated Endo180), that are considered crucially engaged in matrix degradation. uPAR and uPARAP have highly diverse functions, but on certain cell types they interact with each other in a process that is still incompletely understood. uPAR is a glycosyl-phosphatidylinositol-anchored glycoprotein...

  6. Taare Zameen Par and dyslexic savants

    Science.gov (United States)

    Chakravarty, Ambar

    2009-01-01

    The film Taare Zameen Par (Stars upon the Ground) portrays the tormented life at school and at home of a child with dyslexia and his eventual success after his artistic talents are discovered by his art teacher at the boarding school. The film hints at a curious neurocognitive phenomenon of creativity in the midst of language disability, as exemplified in the lives of people like Leonardo da Vinci and Albert Einstein, both of whom demonstrated extraordinary creativity even though they were probably affected with developmental learning disorders. It has been hypothesized that a developmental delay in the dominant hemisphere most likely ‘disinhibits’ the nondominant parietal lobe, unmasking talents—artistic or otherwise—in some such individuals. It has been suggested that, in remedial training, children with learning disorders be encouraged to develop such hidden talents to full capacity, rather than be subjected to the usual overemphasis on the correction of the disturbed coded symbol operations. PMID:20142854

  7. Taare Zameen Par and dyslexic savants

    Directory of Open Access Journals (Sweden)

    Chakravarty Ambar

    2009-01-01

    Full Text Available The film Taare Zameen Par (Stars upon the Ground portrays the tormented life at school and at home of a child with dyslexia and his eventual success after his artistic talents are discovered by his art teacher at the boarding school. The film hints at a curious neurocognitive phenomenon of creativity in the midst of language disability, as exemplified in the lives of people like Leonardo da Vinci and Albert Einstein, both of whom demonstrated extraordinary creativity even though they were probably affected with developmental learning disorders. It has been hypothesized that a developmental delay in the dominant hemisphere most likely ′disinhibits′ the nondominant parietal lobe, unmasking talents-artistic or otherwise-in some such individuals. It has been suggested that, in remedial training, children with learning disorders be encouraged to develop such hidden talents to full capacity, rather than be subjected to the usual overemphasis on the correction of the disturbed coded symbol operations.

  8. Investigation of APS PAR Vertical Beam Instability

    CERN Document Server

    Yao, Chihyuan; Sereno, Nicholas S; Yang Bing Xin

    2005-01-01

    The Advanced Photon Source (APS) particle accumulator ring (PAR) is a 325-MeV storage ring that collects and compresses linac pulse trains into a single bunch for booster injection. A vertical beam instability has been observed when only a single linac bunch is injected and the total beam charge is from 0.15 to 0.7 nC. The instability starts about 80 ms after the injection, lasts about 160 ms, and is highly reproducible. We performed spectral measurement and time-resolved imaging with both a gated-intensified camera and a streak camera in order to characterize this instability. Initial analysis of the data indicates that the instability is due to ion trapping. A stable lattice was established as result of the investigation. This report summarizes the experimental results and gives some preliminary analysis.

  9. PAR1 activation affects the neurotrophic properties of Schwann cells.

    Science.gov (United States)

    Pompili, Elena; Fabrizi, Cinzia; Somma, Francesca; Correani, Virginia; Maras, Bruno; Schininà, Maria Eugenia; Ciraci, Viviana; Artico, Marco; Fornai, Francesco; Fumagalli, Lorenzo

    2017-03-01

    Protease-activated receptor-1 (PAR1) is the prototypic member of a family of four G-protein-coupled receptors that signal in response to extracellular proteases. In the peripheral nervous system, the expression and/or the role of PARs are still poorly investigated. High PAR1 mRNA expression was found in the rat dorsal root ganglia and the signal intensity of PAR1 mRNA increased in response to sciatic nerve transection. In the sciatic nerve, functional PAR1 receptor was reported at the level of non-compacted Schwann cell myelin microvilli of the nodes of Ranvier. Schwann cells are the principal population of glial cells of the peripheral nervous system which myelinate axons playing an important role during axonal regeneration and remyelination. The present study was undertaken in order to determine if the activation of PAR1 affects the neurotrophic properties of Schwann cells. Our results suggest that the stimulation of PAR1 could potentiate the Schwann cell ability to favour nerve regeneration. In fact, the conditioned medium obtained from Schwann cell cultures challenged with a specific PAR1 activating peptide (PAR1 AP) displays increased neuroprotective and neurotrophic properties with respect to the culture medium from untreated Schwann cells. The proteomic analysis of secreted proteins in untreated and PAR1 AP-treated Schwann cells allowed the identification of factors differentially expressed in the two samples. Some of them (such as macrophage migration inhibitory factor, matrix metalloproteinase-2, decorin, syndecan 4, complement C1r subcomponent, angiogenic factor with G patch and FHA domains 1) appear to be transcriptionally regulated after PAR1 AP treatment as shown by RT-PCR. Copyright © 2017 Elsevier Inc. All rights reserved.

  10. TMS suppression of right pars triangularis, but not pars opercularis, improves naming in aphasia

    Science.gov (United States)

    Naeser, Margaret A.; Martin, Paula I.; Theoret, Hugo; Kobayashi, Masahito; Fregni, Felipe; Nicholas, Marjorie; Tormos, Jose M.; Steven, Megan S.; Baker, Errol H.; Pascual-Leone, Alvaro

    2011-01-01

    This study sought to discover if an optimum 1 cm2 area in the non-damaged right hemisphere (RH) was present, which could temporarily improve naming in chronic, nonfluent aphasia patients when suppressed with repetitive transcranial magnetic stimulation (rTMS). Ten minutes of slow, 1 Hz rTMS was applied to suppress different RH ROIs in eight aphasia cases. Picture naming and response time (RT) were examined before, and immediately after rTMS. In aphasia patients, suppression of right pars triangularis (PTr) led to significant increase in pictures named, and significant decrease in RT. Suppression of right pars opercularis (POp), however, led to significant increase in RT, but no change in number of pictures named. Eight normals named all pictures correctly; similar to aphasia patients, RT significantly decreased following rTMS to suppress right PTr, versus right POp. Differential effects following suppression of right PTr versus right POp suggest different functional roles for these regions. PMID:21864891

  11. Bacterial mitosis: partitioning protein ParA oscillates in spiral-shaped structures and positions plasmids at mid-cell

    DEFF Research Database (Denmark)

    Ebersbach, Gitte; Gerdes, Kenn; Charbon, Gitte Ebersbach

    2004-01-01

    The par2 locus of Escherichia coli plasmid pB171 encodes oscillating ATPase ParA, DNA binding protein ParB and two cis-acting DNA regions to which ParB binds (parC1 and parC2). Three independent techniques were used to investigate the subcellular localization of plasmids carrying par2. In cells w...

  12. ParABS system in chromosome partitioning in the bacterium Myxococcus xanthus.

    Directory of Open Access Journals (Sweden)

    Antonio A Iniesta

    Full Text Available Chromosome segregation is an essential cellular function in eukaryotic and prokaryotic cells. The ParABS system is a fundamental player for a mitosis-like process in chromosome partitioning in many bacterial species. This work shows that the social bacterium Myxococcus xanthus also uses the ParABS system for chromosome segregation. Its large prokaryotic genome of 9.1 Mb contains 22 parS sequences near the origin of replication, and it is shown here that M. xanthus ParB binds preferentially to a consensus parS sequence in vitro. ParB and ParA are essential for cell viability in M. xanthus as in Caulobacter crescentus, but unlike in many other bacteria. Absence of ParB results in anucleate cells, chromosome segregation defects and loss of viability. Analysis of ParA subcellular localization shows that it clusters at the poles in all cells, and in some, in the DNA-free cell division plane between two chromosomal DNA masses. This ParA localization pattern depends on ParB but not on FtsZ. ParB inhibits the nonspecific interaction of ParA with DNA, and ParA colocalizes with chromosomal DNA only when ParB is depleted. The subcellular localization of ParB suggests a single ParB-parS complex localized at the edge of the nucleoid, next to a polar ParA cluster, with a second ParB-parS complex migrating after the replication of parS takes place to the opposite nucleoid edge, next to the other polar ParA cluster.

  13. The protein kinase SIK downregulates the polarity protein Par3

    DEFF Research Database (Denmark)

    Vanlandewijck, Michael; Dadras, Mahsa Shahidi; Lomnytska, Marta

    2018-01-01

    that SIK can potentially phosphorylate the polarity complex protein Par3, an established regulator of tight junction assembly. SIK associates with Par3, and induces degradation of Par3 that can be prevented by proteasomal and lysosomal inhibition or by mutation of Ser885, a putative phosphorylation site...... protein. HighSIKmRNA expression also correlates with lower chance for survival in various carcinomas. In specific human breast cancer samples, aneuploidy of tumor cells best correlated with cytoplasmic SIK distribution, and SIK expression correlated with TGFβ/Smad signaling activity and low...... or undetectable expression of Par3. Our model suggests that SIK can act directly on the polarity protein Par3 to regulate tight junction assembly....

  14. Recombination in the human Pseudoautosomal region PAR1.

    Directory of Open Access Journals (Sweden)

    Anjali G Hinch

    2014-07-01

    Full Text Available The pseudoautosomal region (PAR is a short region of homology between the mammalian X and Y chromosomes, which has undergone rapid evolution. A crossover in the PAR is essential for the proper disjunction of X and Y chromosomes in male meiosis, and PAR deletion results in male sterility. This leads the human PAR with the obligatory crossover, PAR1, to having an exceptionally high male crossover rate, which is 17-fold higher than the genome-wide average. However, the mechanism by which this obligatory crossover occurs remains unknown, as does the fine-scale positioning of crossovers across this region. Recent research in mice has suggested that crossovers in PAR may be mediated independently of the protein PRDM9, which localises virtually all crossovers in the autosomes. To investigate recombination in this region, we construct the most fine-scale genetic map containing directly observed crossovers to date using African-American pedigrees. We leverage recombination rates inferred from the breakdown of linkage disequilibrium in human populations and investigate the signatures of DNA evolution due to recombination. Further, we identify direct PRDM9 binding sites using ChIP-seq in human cells. Using these independent lines of evidence, we show that, in contrast with mouse, PRDM9 does localise peaks of recombination in the human PAR1. We find that recombination is a far more rapid and intense driver of sequence evolution in PAR1 than it is on the autosomes. We also show that PAR1 hotspot activities differ significantly among human populations. Finally, we find evidence that PAR1 hotspot positions have changed between human and chimpanzee, with no evidence of sharing among the hottest hotspots. We anticipate that the genetic maps built and validated in this work will aid research on this vital and fascinating region of the genome.

  15. Effects of thrombin, PAR-1 activating peptide and a PAR-1 antagonist on umbilical artery resistance in vitro

    Directory of Open Access Journals (Sweden)

    Elliott John T

    2005-02-01

    Full Text Available Abstract Background The non-thrombotic effects of thrombin in cardiovascular tissues, as mediated via the protease activated receptors (PARs, and particularly PAR-1, have been the focus of much recent research. The aims of this study were to evaluate the effects of thrombin, a specific PAR-1 activating peptide (PAR1-AP, and a PAR-1 antagonist on human umbilical artery tone in vitro. Methods Human umbilical artery samples were obtained from 17 women at term. Arterial rings were suspended under physiologic conditions for isometric recording. The in vitro effects of thrombin (0.5 units/mL to 3 units/mL, PAR1-AP TFLLR-NH2 [10(-9 to 10(-6 M], and PAR-1 antagonist (N-trans cinnamoyl- p-fluoroPhe-p-guanidinoPhe-Leu-Arg-Orn-NH2 [10(-9 M to 10(-5 M] on umbilical artery tone were measured. Results Both thrombin and TFLLR-NH2 exerted a potent cumulative vasodilatory effect on human umbilical artery resistance (P 0.05. Conclusion These findings highlight a potential role for thrombin and PAR-1 receptors in vascular regulation of feto-placental blood flow in normal pregnancy, and in association with the vascular lesions associated with IUGR and pre-eclampsia.

  16. Le rendement dans l’utilisation du clavier d’ordinateur pour écrire chez les personnes ayant un trouble du spectre de l’autisme / Performance using a computer keyboard for writing among persons with an autism spectrum disorder

    Directory of Open Access Journals (Sweden)

    Claire Dumont

    2015-03-01

    Full Text Available Les personnes ayant un trouble du spectre de l’autisme (TSA ont fréquemment des problèmes graphomoteurs. Ces difficultés ont à leur tour des répercussions sur de nombreuses occupations, le rendement scolaire et le développement de la personne. Dans cette situation, l’écriture avec un clavier peut s’avérer une alternative pertinente. Cette étude vise à décrire le rendement des enfants ayant un TSA dans leur réalisation de tâches avec le clavier d’ordinateur et de le comparer à celui des enfants à développement typique. Le Test du rendement dans l’utilisation de l’ordinateur a été administré à un échantillon de 53 enfants âgés entre six et 15 ans ayant un TSA. Les résultats suggèrent qu’ils peuvent avoir un rendement équivalent, supérieur ou inférieur en fonction de leurs caractéristiques et du type de tâche. Le test permet également d’observer plusieurs particularités de leurs processus d’apprentissage. Des suggestions pour l’amélioration des connaissances et des pratiques en découlent. Persons with an autism spectrum disorder (ASD frequently have graphomotor problems. These difficulties in turn have repercussions on numerous tasks, on academic performance and on personal development. In this situation, writing using a keyboard can be a relevant alternative. This study aims to describe the performance of children with an ASD in performing tasks using a computer keyboard and to compare it with that of children whose development is typical. The Performance using a computer test was administered to a sample of 53 children with an ASD, aged 6 to 15. Findings suggest that they can offer an equal, superior or inferior performance depending on their characteristics and on the type of task performed. The test also allows the observation of several characteristics in their learning processes. Suggestions for the improvement of the knowledge base and practices follow.

  17. Movement and equipositioning of plasmids by ParA filament disassembly

    DEFF Research Database (Denmark)

    Ringgaard, Simon; van Zon, Jeroen; Howard, Martin

    2009-01-01

    Bacterial plasmids encode partitioning (par) loci that confer stable plasmid inheritance. We showed previously that, in the presence of ParB and parC encoded by the par2 locus of plasmid pB171, ParA formed cytoskeletal-like structures that dynamically relocated over the nucleoid. Simultaneously......, the par2 locus distributed plasmids regularly over the nucleoid. We show here that the dynamic ParA patterns are not simple oscillations. Rather, ParA nucleates and polymerizes in between plasmids. When a ParA assembly reaches a plasmid, the assembly reaction reverses into disassembly. Strikingly......, plasmids consistently migrate behind disassembling ParA cytoskeletal structures, suggesting that ParA filaments pull plasmids by depolymerization. The perpetual cycles of ParA assembly and disassembly result in continuous relocation of plasmids, which, on time averaging, results in equidistribution...

  18. An Integrated Model for Computer Aided Reservoir Description : from Outcrop Study to Fluid Flow Simulations Un logiciel intégré pour une description des gisements assistée par ordinateur : de l'étude d'un affleurement aux simulations de l'écoulement des fluides

    Directory of Open Access Journals (Sweden)

    Guerillot D.

    2006-11-01

    Full Text Available An accurate understanding of the internal architecture of a reservoir is required to improve reservoir management for oil recovery. Geostatistical methods give an image of this architecture. The purpose of this paper is to show how this lithological description could be used for reservoir simulation. For this purpose, scale averaging problems must be solved for non-additive variables. A method giving a full effective permeability matrix is proposed. The integrated software described here starts from core analysis and lithologic logs to provide data for reservoir simulators. Each of the steps of this interactive and graphic system is explained here. Pour faire de bonnes prévisions de production pour un gisement pétrolifère, il est nécessaire de connaître précisément son architecture interne. Les méthodes géostatistiques donnent une représentation de cette architecture. L'objectif de cet article est de montrer une façon d'utiliser cette description lithologique pour la simulation des réservoirs. Il faut alors résoudre des problèmes de changement d'échelle pour les variables qui ne sont pas additives. On propose une méthode d'estimation de la perméabilité effective sous la forme d'une matrice pleine. Le logiciel intégré que l'on décrit part de l'analyse des carottes et des diagraphies en lithologies et fournit des données pour les simulateurs de gisement. On détaille ici chaque étape de ce système interactif graphique.

  19. Development of an E-Prime Based Computer Simulation of an Interactive Human Rights Violation Negotiation Script (Developpement d’un Programme de Simulation par Ordinateur Fonde sur le Logiciel E Prime pour la Negociation Interactive en cas de Violation des Droits de la Personne)

    Science.gov (United States)

    2010-12-01

    graphic. First, as indicated by the scientific authority, colouring the Sgt dialogue would provide important feedback about the Sgt’s mood . It is expected...to familiarize themselves with the interface of the training session (e.g., font, background colour , response keys). Information Information about...object: Setup, is the programming code for the presentation of two sources of feedback. One is Sgt text font colour , and the second is the meter

  20. Limnological database for Par Pond: 1959 to 1980

    Energy Technology Data Exchange (ETDEWEB)

    Tilly, L.J.

    1981-03-01

    A limnological database for Par Pond, a cooling reservoir for hot reactor effluent water at the Savannah River Plant, is described. The data are derived from a combination of research and monitoring efforts on Par Pond since 1959. The approximately 24,000-byte database provides water quality, primary productivity, and flow data from a number of different stations, depths, and times during the 22-year history of the Par Pond impoundment. The data have been organized to permit an interpretation of the effects of twenty years of cooling system operations on the structure and function of an aquatic ecosystem.

  1. Limnological database for Par Pond: 1959 to 1980

    International Nuclear Information System (INIS)

    Tilly, L.J.

    1981-03-01

    A limnological database for Par Pond, a cooling reservoir for hot reactor effluent water at the Savannah River Plant, is described. The data are derived from a combination of research and monitoring efforts on Par Pond since 1959. The approximately 24,000-byte database provides water quality, primary productivity, and flow data from a number of different stations, depths, and times during the 22-year history of the Par Pond impoundment. The data have been organized to permit an interpretation of the effects of twenty years of cooling system operations on the structure and function of an aquatic ecosystem

  2. PSD-Constrained PAR Reduction for DMT/OFDM

    Science.gov (United States)

    Andgart, Niklas; Krongold, Brian S.; Ödling, Per; Johansson, Albin; Börjesson, Per Ola

    2004-12-01

    Common to all DMT/OFDM systems is a large peak-to-average ratio (PAR), which can lead to low power efficiency and nonlinear distortion. Tone reservation uses unused or reserved tones to design a peak-canceling signal to lower the PAR of a transmit block. In DMT ADSL systems, the power allocated to these tones may be limited due to crosstalk issues with many users in one twisted pair bundle. This PSD limitation not only limits PAR reduction ability, but also makes the optimization problem more challenging to solve. Extending the recently proposed active set tone reservation method, we develop an efficient algorithm with performance close to the optimal solution.

  3. Protease-activated receptor (PAR2, but not PAR1, is involved in collateral formation and anti-inflammatory monocyte polarization in a mouse hind limb ischemia model.

    Directory of Open Access Journals (Sweden)

    Lisa G van den Hengel

    Full Text Available AIMS: In collateral development (i.e. arteriogenesis, mononuclear cells are important and exist as a heterogeneous population consisting of pro-inflammatory and anti-inflammatory/repair-associated cells. Protease-activated receptor (PAR1 and PAR2 are G-protein-coupled receptors that are both expressed by mononuclear cells and are involved in pro-inflammatory reactions, while PAR2 also plays a role in repair-associated responses. Here, we investigated the physiological role of PAR1 and PAR2 in arteriogenesis in a murine hind limb ischemia model. METHODS AND RESULTS: PAR1-deficient (PAR1-/-, PAR2-deficient (PAR2-/- and wild-type (WT mice underwent femoral artery ligation. Laser Doppler measurements revealed reduced post-ischemic blood flow recovery in PAR2-/- hind limbs when compared to WT, while PAR1-/- mice were not affected. Upon ischemia, reduced numbers of smooth muscle actin (SMA-positive collaterals and CD31-positive capillaries were found in PAR2-/- mice when compared to WT mice, whereas these parameters in PAR1-/- mice did not differ from WT mice. The pool of circulating repair-associated (Ly6C-low monocytes and the number of repair-associated (CD206-positive macrophages surrounding collaterals in the hind limbs were increased in WT and PAR1-/- mice, but unaffected in PAR2-/- mice. The number of repair-associated macrophages in PAR2-/- hind limbs correlated with CD11b- and CD115-expression on the circulating monocytes in these animals, suggesting that monocyte extravasation and M-CSF-dependent differentiation into repair-associated cells are hampered. CONCLUSION: PAR2, but not PAR1, is involved in arteriogenesis and promotes the repair-associated response in ischemic tissues. Therefore, PAR2 potentially forms a new pro-arteriogenic target in coronary artery disease (CAD patients.

  4. Positron Accumulator Ring (PAR) power supply

    International Nuclear Information System (INIS)

    Fathizadeh, M.

    1995-01-01

    The Positron Accumulator Ring (PAR) consists of 8 dipole magnets connected in series. These magnets are energized via one 12-pulse dc power supply. The power supply consists of four phase controlled half-wave wye group converters. Each of the two half-wave converters are connected through an interphase transformer to obtain a full-wave converter with 120 degrees conduction. The input voltage for these two half-wave converters are 180 degrees apart. The two full-wave converters are connected in parallel through a third interphase transformer. This type of connection of the converters not only provides the required output current, it also improves the input power factor of the power supply. The output of the wye group converters is filtered through a passive L-R-C filter to reduce the ripple content of the output current. At low current values of the power supply the current ripple is high, thus a large filter is needed, which adds to the cost of the power supply, however at high output current levels, the current ripple is less severe. The large size of the filter can be reduced by adding an anti-parallel rectifier diode(D1) to the output of the power supply. A freewheeling diode(D2) is connected before the choke to circulate the current once the power supply is turned off. In order to measure the current in the magnet a high precision, low drift, zero flux current transductor is used. This transductor senses the magnet current which provides a feedback signal to control the gating of the converter's thyristors. A true 14 bit Digital to Analog Converter (DAC) is programmed by the control computer for the required current value, providing a reference for the current regulator. Fast correction of the line transients is provided by a relatively fast voltage loop controlled by a high gain slow response current loop

  5. Parálisis cerebral Cerebral palsy

    Directory of Open Access Journals (Sweden)

    Jorge Malagon Valdez

    2007-01-01

    Full Text Available El término parálisis cerebral (PC engloba a un gran número de síndromes neurológicos clínicos, de etiología diversa. Estos síndromes se caracterizan por tener una sintomatología común: los trastornos motores. Algunos autores prefieren manejar términos como "encefalopatía fija", "encefalopatías no evolutivas". Se mencionan la utilidad de programas de intervención temprana y métodos especiales de rehabilitación, así como el manejo de las deficiencias asociadas como la epilepsia, deficiencia mental, trastornos del lenguaje, audición, visión, déficit de la atención que mejoran el pronóstico de manera significativa. El pronóstico también depende de la gravedad del padecimiento y de las manifestaciones asociadas.The term cerebral palsy (CP, is used for a great number of clinical neurological syndromes. The syndromes are characterized by having a common cause, motor defects. It is important, because they can cause a brain damage by presenting motor defects and some associated deficiencies, such as mental deficiency, epilepsy, language and visual defects and pseudobulbar paralysis, with the nonevolving fact. Some authors prefer using terms such as "non-evolving encephalopathies". In the treatment the utility of prevention programs of early stimulation and special rehabilitation methods, and treatment of associated deficiencies such as epilepsy, mental deficiency, language, audition and visual problems, and the attention deficit improve the prognosis in an important way. The prognosis depends on the severity of the disease and the associated manifestations.

  6. First-in-human uPAR PET

    DEFF Research Database (Denmark)

    Persson, Morten; Skovgaard, Dorthe; Brandt-Larsen, Malene

    2015-01-01

    A first-in-human clinical trial with Positron Emission Tomography (PET) imaging of the urokinase-type plasminogen activator receptor (uPAR) in patients with breast, prostate and bladder cancer, is described. uPAR is expressed in many types of human cancers and the expression is predictive...... of invasion, metastasis and indicates poor prognosis. uPAR PET imaging therefore holds promise to be a new and innovative method for improved cancer diagnosis, staging and individual risk stratification. The uPAR specific peptide AE105 was conjugated to the macrocyclic chelator DOTA and labeled with (64)Cu...... for targeted molecular imaging with PET. The safety, pharmacokinetic, biodistribution profile and radiation dosimetry after a single intravenous dose of (64)Cu-DOTA-AE105 were assessed by serial PET and computed tomography (CT) in 4 prostate, 3 breast and 3 bladder cancer patients. Safety assessment...

  7. La preuve apportée par les sciences

    Directory of Open Access Journals (Sweden)

    1997-04-01

    Full Text Available A propos d´une enquête menée par deux immunologistes de l´Université de Göteborg, rapportée par la très sérieuse revue Nature, le journal Le Monde n´hésitait pas à titrer : " La preuve du sexisme apportée par les sciences ". Les auteurs avaient en effet pu démontrer, irréfutables tests statistiques à l´appui, que, pour obtenir une bourse de post-doctorat offerte par le Swedisch Medical Research Council, les femmes devaient être deux fois et demie plus productives que les hommes ! Nous voulons...

  8. Croissance epitaxiale de GaAs sur substrats de Ge par epitaxie par faisceaux chimiques

    Science.gov (United States)

    Belanger, Simon

    La situation energetique et les enjeux environnementaux auxquels la societe est confrontee entrainent un interet grandissant pour la production d'electricite a partir de l'energie solaire. Parmi les technologies actuellement disponibles, la filiere du photovoltaique a concentrateur solaire (CPV pour concentrator photovoltaics) possede un rendement superieur et mi potentiel interessant a condition que ses couts de production soient competitifs. La methode d'epitaxie par faisceaux chimiques (CBE pour chemical beam epitaxy) possede plusieurs caracteristiques qui la rendent interessante pour la production a grande echelle de cellules photovoltaiques a jonctions multiples a base de semi-conducteurs III-V. Ce type de cellule possede la meilleure efficacite atteinte a ce jour et est utilise sur les satellites et les systemes photovoltaiques a concentrateur solaire (CPV) les plus efficaces. Une des principales forces de la technique CBE se trouve dans son potentiel d'efficacite d'utilisation des materiaux source qui est superieur a celui de la technique d'epitaxie qui est couramment utilisee pour la production a grande echelle de ces cellules. Ce memoire de maitrise presente les travaux effectues dans le but d'evaluer le potentiel de la technique CBE pour realiser la croissance de couches de GaAs sur des substrats de Ge. Cette croissance constitue la premiere etape de fabrication de nombreux modeles de cellules solaires a haute performance decrites plus haut. La realisation de ce projet a necessite le developpement d'un procede de preparation de surface pour les substrats de germanium, la realisation de nombreuses sceances de croissance epitaxiale et la caracterisation des materiaux obtenus par microscopie optique, microscopie a force atomique (AFM), diffraction des rayons-X a haute resolution (HRXRD), microscopie electronique a transmission (TEM), photoluminescence a basse temperature (LTPL) et spectrometrie de masse des ions secondaires (SIMS). Les experiences ont permis

  9. Priapisme induit par la chlorpromazine: A propos de deux cas

    African Journals Online (AJOL)

    I. Marrag

    stratégies thérapeutiques par les cliniciens permet de préserver la vie sexuelle des patients, souvent touchée par la prescription des traitements psychotropes. Consentement. Le consentement des patients etait demande et approuve. Assentiment du comité d'étique. La comité d'éthique a approuvé ce travail sans qu'il est ...

  10. Prise en charge des intoxications par envenimation chez les enfants ...

    African Journals Online (AJOL)

    Les signes cliniques étaient dominés par les douleurs (98%) suivies des hémorragies (73,80%) pour les morsures de serpent, la douleur pour les piqures de scorpion (100%) et les oedèmes pour les piqures d'abeilles (100%). Les cas de morsure de serpent ont été traités par le sérum antivenimeux polyvalent. Conclusion: ...

  11. Analysis of ParB-centromere interactions by multiplex SPR imaging reveals specific patterns for binding ParB in six centromeres of Burkholderiales chromosomes and plasmids.

    Directory of Open Access Journals (Sweden)

    Flavien Pillet

    Full Text Available Bacterial centromeres-also called parS, are cis-acting DNA sequences which, together with the proteins ParA and ParB, are involved in the segregation of chromosomes and plasmids. The specific binding of ParB to parS nucleates the assembly of a large ParB/DNA complex from which ParA-the motor protein, segregates the sister replicons. Closely related families of partition systems, called Bsr, were identified on the chromosomes and large plasmids of the multi-chromosomal bacterium Burkholderia cenocepacia and other species from the order Burkholeriales. The centromeres of the Bsr partition families are 16 bp palindromes, displaying similar base compositions, notably a central CG dinucleotide. Despite centromeres bind the cognate ParB with a narrow specificity, weak ParB-parS non cognate interactions were nevertheless detected between few Bsr partition systems of replicons not belonging to the same genome. These observations suggested that Bsr partition systems could have a common ancestry but that evolution mostly erased the possibilities of cross-reactions between them, in particular to prevent replicon incompatibility. To detect novel similarities between Bsr partition systems, we have analyzed the binding of six Bsr parS sequences and a wide collection of modified derivatives, to their cognate ParB. The study was carried out by Surface Plasmon Resonance imaging (SPRi mulitplex analysis enabling a systematic survey of each nucleotide position within the centromere. We found that in each parS some positions could be changed while maintaining binding to ParB. Each centromere displays its own pattern of changes, but some positions are shared more or less widely. In addition from these changes we could speculate evolutionary links between these centromeres.

  12. Attenuated vasodilator effectiveness of protease-activated receptor 2 agonist in heterozygous par2 knockout mice.

    Directory of Open Access Journals (Sweden)

    John C Hennessey

    Full Text Available Studies of homozygous PAR2 gene knockout mice have described a mix of phenotypic effects in vitro and in vivo. However, there have been few studies of PAR2 heterozygous (wild-type/knockout; PAR2-HET mice. The phenotypes of many hemi and heterozygous transgenic mice have been described as intermediates between those of wild-type and knockout animals. In our study we aimed to determine the effects of intermediary par2 gene zygosity on vascular tissue responses to PAR2 activation. Specifically, we compared the vasodilator effectiveness of the PAR2 activating peptide 2-furoyl-LIGRLO-amide in aortas of wild-type PAR2 homozygous (PAR2-WT and PAR2-HET mice. In myographs under isometric tension conditions, isolated aortic rings were contracted by alpha 1-adrenoeceptor agonist (phenylephrine, and thromboxane receptor agonist (U46619 and then relaxation responses by the additions of 2-furoyl-LIGRLO-amide, acetylcholine, and nitroprusside were recorded. A Schild regression analysis of the inhibition by a PAR2 antagonist (GB-83 of PAR2 agonist-induced aortic ring relaxations was used to compare receptor expression in PAR2-WT to PAR2-HET. PAR2 mRNA in aortas was measured by quantitative real-time PCR. In aortas contracted by either phenylephrine or U46619, the maximum relaxations induced by 2-furoyl-LIGRLO-amide were less in PAR2-HET than in the gender-matched PAR2-WT. GB-83 was 3- to 4-fold more potent for inhibition of 2fly in PAR2-HET than in PAR2-WT. PAR2 mRNA content of aortas from PAR2-HET was not significantly different than in PAR2-WT. Acetylcholine- and nitroprusside-induced relaxations of aortas from PAR2-HET were not significantly different than in PAR2-WT and PAR2 knockout. An interesting secondary finding was that relaxations induced by agonists of PAR2 and muscarinic receptors were larger in females than in males. We conclude that the lower PAR2-mediated responses in PAR2-HET aortas are consistent with evidence of a lower quantity of functional

  13. Une terreur par l’image

    Directory of Open Access Journals (Sweden)

    Annie DULONG

    2011-09-01

    Full Text Available Si d’autres événements — Hiroshima, la découverte des camps de concentration, la chute du mur de Berlin — ont, au cours du XXe siècle, marqué suffisamment l’imaginaire pour trouver leur réponse dans des œuvres d’art, le 11 septembre 2001 pose la question de la fictionnalisation autrement : il ne s’agit plus tant de combler les manques de la représentation, liés à l’absence d’images ou au délai dans leur dévoilement, mais bien de composer avec l’omniprésence d’une représentation martelée à la télévision et sur Internet. Que cette représentation soit partielle, tronquée et qu’il lui manque la présence des corps, ces grands absents des photographies et des images tournées par les journalistes, ne change rien au fait que c’est avec le trop-plein que les artistes doivent maintenant négocier.Cet article s’intéresse aux romans qui traitent l’événement de front au lieu de l’aborder sur un mode mineur, et a pour objectif de tracer un portrait de la représentation des médias dans les romans du 11 septembre 2001. Ces romans, outre le fait qu’ils traitent des événements de New York, ont comme point commun un personnage, ou décor : les médias, représentés par la télévision, l’Internet, les photographies de presse, interviennent dans les récits d’une manière significative et témoignent de la force brute des images. À travers une étude de certains des mécanismes à l’œuvre dans The Writing on the Wall (Lynne Sharon Schwartz, Extremely Loud and Incredibly Close (Jonathan Safran Foer, Falling Man (Don DeLillo et A Disorder Peculiar to the Country (Ken Kalfus, il s’agira de proposer des réponses à ces quelques questions : quel rôle les médias jouent-ils, et comment participent-ils au récit ? Quelle pression les images exercent-elles sur les personnages ? Que révèlent les personnages enfants dans leur rapport aux médias ? Quelle critique, finalement, les romans

  14. Serum suPAR in patients with FSGS: trash or treasure?

    NARCIS (Netherlands)

    Maas, R.J.H.; Deegens, J.K.J.; Wetzels, J.F.M.

    2013-01-01

    The urokinase-type plasminogen activator receptor (uPAR) has important functions in cell migration. uPAR can be shed from the cell membrane resulting in soluble uPAR (suPAR). Further cleavage gives rise to shorter fragments with largely unknown functions. Recent studies have demonstrated that both

  15. Par Pond vegetation status Summer 1995 -- June survey descriptive summary

    International Nuclear Information System (INIS)

    Mackey, H.E. Jr.; Riley, R.S.

    1995-06-01

    The water level of Par Pond was lowered approximately 20 feet in mid-1991 in order to protect downstream residents from possible dam failure suggested by subsidence on the downstream slope of the dam and to repair the dam. This lowering exposed both emergent and nonemergent macrophyte beds to drying conditions resulting in extensive losses. A survey of the shoreline aquatic plant communities in June 1995, three months after the refilling of Par Pond to approximately 200 feet above mean sea level, indicated that much of the original plant communities and the intermediate shoreline communities present on the exposed sediments have been lost. The extensive old-field and emergent marsh communities that were present on the exposed shoreline during the drawdown have been flooded and much of the pre-drawdown Par Pond aquatic plant communities have not had sufficient time for re-establishment. The shoreline does, however, have extensive beds of maidencane which extend from the shoreline margin to areas as deep as 2 and perhaps 3 meters. Scattered individual plants of lotus and watershield are common and may indicate likely directions of future wetland development in Par Pond. In addition, within isolated coves, which apparently received ground water seepage and/or stream surface flows during the period of the Par Pond draw down, extensive beds of waterlilies and spike rush are common. Invasion of willow and red maple occurred along the lake shoreline as well. Although not absent from this survey, evidence of the extensive redevelopment of the large cattail and eel grass beds was not observed in this first survey of Par Pond. Future surveys during the growing seasons of 1995, 1996, and 1997 along with the evaluation of satellite date to map the areal extent of the macrophyte beds of Par Pond are planned

  16. Par Pond vegetation status Summer 1995 -- September survey descriptive summary

    International Nuclear Information System (INIS)

    Mackey, H.E. Jr.; Riley, R.S.

    1995-09-01

    The water level of Par Pond was lowered approximately 20 feet in mid-1991 in order to protect downstream residents from possible dam failure suggested by subsidence on the downstream slope of the dam and to repair the dam. This lowering exposed both emergent and nonemergent macrophyte beds to drying conditions resulting in extensive losses. A survey of the emergent shoreline aquatic plant communities began in June 1995, three months after the refilling of Par Pond to approximately 200 feet above mean sea level and continued with this mid-September survey. Communities similar to the pre-drawdown Par Pond aquatic plant communities are becoming re-established; especially, beds of maidencane, lotus, waterlily, and watershield are now extensive and well established. Cattail occurrence continues to increase, but large beds common to Par Pond prior to the drawdown have not formed. Future surveys during the late growing seasons of 1995, and throughout 1996 and 1997, along with the evaluation of satellite data to map the areal extent of the macrophyte beds of Par Pond, are planned

  17. Plasma suPAR is lowered by smoking cessation

    DEFF Research Database (Denmark)

    Eugen-Olsen, Jesper; Ladelund, Steen; Sørensen, Lars Tue

    2016-01-01

    , in smokers, predictive of long-term lung cancer development. Whether smoking cessation impacts the suPAR level is unknown. MATERIALS AND METHODS: Forty-eight smokers were randomized into three groups of 16: (i) continued to smoke 20 cigarettes per day, (ii) refrained from smoking and used transdermal...... nicotine patches and (iii) refrained from smoking and used placebo patches. Nonsmokers were included for comparison. suPAR and C-reactive protein (CRP) levels were measured by ELISA. RESULTS: At baseline, the suPAR level was significantly higher in the 48 smokers (median 3·2 ng mL, IQR (2·5-3·9)) than...... in 46 never smokers (1·9 ng/mL (1·7-2·2)). In smokers randomized to smoking cessation, suPAR levels after 4 weeks of stopping were decreased and no longer significantly different from the never smokers values. SuPAR decreased in both those who received a placebo as well as nicotine patch. Interestingly...

  18. Enseignement technique/Technical Training

    CERN Multimedia

    1998-01-01

    Conception électronique/Electronic Design - Conception assistée par ordinateur/Computer-Aided Design - PCAD13 CADENCE - LabVIEW - Automatisme et mesures/Automation & Measures - Fieldbuses/Divers/Miscellaneous

  19. Couches Minces de Titanate de Baryum Par Depot Organometallique

    Science.gov (United States)

    Ousi Benomar, Wahib

    1993-01-01

    Nous avons demontre la possibilite de realiser des couches minces de titanate de baryum par depot organometallique. Les films sont obtenus apres dissolution d'organometalliques choisis dans un solvant et une cuisson a une temperature determinee par thermogravimetrie. Apres un second traitement thermique a des temperatures plus elevees, les echantillons presentent une structure polycristalline tetragonale; les cristallites sont observes par microscopie electronique a balayage. La mesure de la constante dielectrique a permis de mettre en evidence une transition de phase de la structure tetragonale a la structure cubique a une temperature d'environ 125^circC. Les mesures d'indice ont ete effectuees. On note une augmentation de l'indice de refraction des films avec la temperature indiquant une meilleure densification des films. Nous avons aussi montre qu'il etait possible d'utiliser ce materiau en tant que guide d'onde optique pour pouvoir exploiter ses proprietes electrooptiques dans l'avenir.

  20. Ambroise Paré and 16th century neurosurgery.

    Science.gov (United States)

    Banerjee, Anirban Deep; Nanda, Anil

    2011-04-01

    The luminousness of Ambroise Paré, the surgeon-statesman, has withstood the ravages of time as the mark of a man, a hero, a surgeon-par-excellence, and above all, a benevolent philosopher. A self-made individual, his tryst with the art of surgery emanated from the literally non-stop battlefields of 16th century feudal Europe. Although a maverick in the medical world of his times; he rose from the humblest origins to the highest echelons solely as a result of his own genius and diligence. Among his mammoth contributions to the renaissance of surgery, Paré did perform many procedures which we see as neurosurgical, especially in the realms of neurotrauma and paediatric neurosurgery; the present vignette is an attempt to elucidate the same.

  1. [Ambroise Paré, his death and his historians].

    Science.gov (United States)

    Dumaître, P

    2001-01-01

    Ambroise Paré died December the 20th., 1590. What happened after his death and what are we knowing about his life? Never forgotten, though a lack of care, we were waiting till the XIXth. century to get recollection upon a subject sustained only by accounts of his travels. After Percy, a surgeon who tried to write Paré's biography through the "Biographie universelle ancienne et moderne, de Michaud (1822)" and some second rank authors, Malgaigne is the first who inside a printing of the "Oeuvres complétes de Paré (1840-41)" has a fine look upon the question, though his work is incomplete and allows many mistakes. Doctors Chéreau and Jal, an historian, analysing civil status records, gave new information enlarged by doctors Le Paulmier, Turner and the U.S. native Janet Doe.

  2. Pars Plana Vitrectomy in Treatment of Lens Injury

    Directory of Open Access Journals (Sweden)

    Remzi Avcı

    2013-01-01

    Full Text Available Lens injury due to traumas may present as loss of capsule integrity, cataract, lens subluxation, or lens luxation. In addition, lens subluxation and lens luxation may occur in pseudophakic patients due to trauma. Clear corneal, scleral or sclero-corneal phacoemulsification surgery, pars plana vitrectomy, pars plana vitrectomy with phaco-fragmentation, or pars plana vitrectomy with removal through corneal incision techniques are used in the treatment of lens injury due to traumas. Intraocular lens can be implanted in the bag, sulcus, or anterior chamber during the surgery. Depending on the circumstances, scleral fixated intraocular lenses or iris-claw lenses may also be preferred. Rehabilitation of such patients is not of a great concern today, with the advanced level of vitreoretinal surgery and cataract surgery techniques and with the current state of technology. (Turk J Ophthalmol 2013; 43: 51-4

  3. OXYDATION DU CYCLOHEXANE PAR COMPLEXE DE RUTHÉNIUM

    OpenAIRE

    HAMOUDI, Badreddine

    2008-01-01

    Le complexe RuCl2(PPh3)3 a été préparé dans le but de son application sur la réaction d’oxydation du cyclohexane en cyclhexanol et cyclohexanone. Les analyses par chromatographie en phase gaz sur la phase organique montrent la production de l’alcool et la cétone dans le cas du t-BuOOH comme oxydant, ce qui n’est le cas avec l’eau oxygénée et l’oxygène moléculaire. La réaction a été effectuée dans différents solvants, où l’eau a apportée une meilleure conversion par rapport a...

  4. Protease activated receptor-2 (PAR2): possible target of phytochemicals.

    Science.gov (United States)

    Kakarala, Kavita Kumari; Jamil, Kaiser

    2015-09-01

    The use of phytochemicals either singly or in combination with other anticancer drugs comes with an advantage of less toxicity and minimal side effects. Signaling pathways play central role in cell cycle, cell growth, metabolism, etc. Thus, the identification of phytochemicals with promising antagonistic effect on the receptor/s playing key role in single transduction may have better therapeutic application. With this background, phytochemicals were screened against protease-activated receptor 2 (PAR2). PAR2 belongs to the superfamily of GPCRs and is an important target for breast cancer. Using in silico methods, this study was able to identify the phytochemicals with promising binding affinity suggesting their therapeutic potential in the treatment of breast cancer. The findings from this study acquires importance as the information on the possible agonists and antagonists of PAR2 is limited due its unique mechanism of activation.

  5. PSD-Constrained PAR Reduction for DMT/OFDM

    Directory of Open Access Journals (Sweden)

    Krongold Brian S

    2004-01-01

    Full Text Available Common to all DMT/OFDM systems is a large peak-to-average ratio (PAR, which can lead to low power efficiency and nonlinear distortion. Tone reservation uses unused or reserved tones to design a peak-canceling signal to lower the PAR of a transmit block. In DMT ADSL systems, the power allocated to these tones may be limited due to crosstalk issues with many users in one twisted pair bundle. This PSD limitation not only limits PAR reduction ability, but also makes the optimization problem more challenging to solve. Extending the recently proposed active set tone reservation method, we develop an efficient algorithm with performance close to the optimal solution.

  6. Keratometric alterations following the 25-gauge transconjunctival sutureless pars plana vitrectomy versus the conventional pars plana vitrectomy.

    Science.gov (United States)

    Citirik, Mehmet; Batman, Cosar; Bicer, Tolga; Zilelioglu, Orhan

    2009-09-01

    To assess the alterations in keratometric astigmatism following the 25-gauge transconjunctival sutureless pars plana vitrectomy versus the conventional pars plana vitrectomy. Sixteen consecutive patients were enrolled into the study. Conventional vitrectomy was applied to eight of the cases and 25-gauge transconjunctival sutureless vitrectomy was performed in eight patients. Keratometry was performed before and after the surgery. In the 25-gauge transconjunctival sutureless pars plana vitrectomy group, statistically significant changes were not observed in the corneal curvature in any post-operative follow-up measurement (p > 0.05); whereas in the conventional pars plana vitrectomy group, statistically significant changes were observed in the first postoperative day (p = 0.01) and first postoperative month (p = 0.03). We noted that these changes returned to baseline in three months (p = 0.26). Both 25-gauge transconjunctival sutureless and conventional pars plana vitrectomy are effective surgical modalities for selected diseases of the posterior segment. Surgical procedures are critical for the visual rehabilitation of the patients. The post-operative corneal astigmatism of the vitrectomised eyes can be accurately determined at least two months post-operatively.

  7. Predicting spectral and PAR light attenuation in Greenlandic coastal waters

    DEFF Research Database (Denmark)

    Murray, Ciarán; Markager, Stiig; Stedmon, Colin

    present models for spectral and PAR (photosynthetically active radiation) attenuation in two contrasting Greenlandic fjords, Godthåbsfjord (SW Greenland) and Young Sound (NE Greenland). The fjords differ in the character and concentrations of optically active components present: dissolved organic material...... (CDOM), phytoplankton pigments and inorganic particles. These differences are due in part to hydrography and to the sources of meltwater: respectively, fjord-terminating and land-terminating glaciers. We present a model to explain the variation in spectral and PAR irradiance in terms of the variation...

  8. Ejercicios activos en la parálisis facial

    OpenAIRE

    Bohoyo Aramburu, Cristina

    2013-01-01

    Diseño: Se trata de una revisión bibliográfica en la que se incluyen revisiones sistemáticas y artículos sobre el tratamiento de la parálisis facial mediante ejercicios faciales, que en su conjunto engloban lo que se denomina la “mímicoterapia”. Objetivos: el objetivo principal es determinar la eficacia de los ejercicios faciales activos en el tratamiento de la parálisis de Bell. El objetivo secundario es describir dichos ejercicios. Métodos: se ha realizado una búsqueda mediante la base d...

  9. Peptide-Based Optical uPAR Imaging for Surgery

    DEFF Research Database (Denmark)

    Juhl, Karina; Christensen, Anders; Persson, Morten

    2016-01-01

    Near infrared intra-operative optical imaging is an emerging technique with clear implications for improved cancer surgery by enabling a more distinct delineation of the tumor margins during resection. This modality has the potential to increase the number of patients having a curative radical......-AE105 tumor uptake by a bolus injection of the natural uPAR ligand pro-uPA, and finally 3) the histological colocalization of ICG-AE105 fluorescence and immunohistochemical detected human uPAR on resected tumor slides. Taken together, our data supports the potential use of this probe for intra...

  10. Representaciones sociales de la computadora en usuarios semirrurales de México (Social Representations of Semirural Computer Users of Mexico (Les représentations sociales de l′ordinateur chez les usagers semi-ruraux au Méxique (Representações sociais do computador em usuários semirrurais do México

    Directory of Open Access Journals (Sweden)

    Marco Antoniog González-Pérez

    2012-12-01

    Full Text Available ResumenEste artículo de investigación se deriva de un estudio de campo realizado para identificar representaciones sociales (RS de la computadora en usuarios de los Centros Comunitarios de Aprendizaje del Instituto Tecnológico y de Estudios Superiores de Monterrey, ITESM. Se aplicaron dos instrumentos: prueba de aso- ciación libre y guion de entrevista a muestras de 217 sujetos, en la primera condición y 31, en la segunda. El estudio se realizó en Chapa de Mota y Villas del Car- bón, Estado de México. Se mostraron representacio- nes sociales, RS, cambiantes entre usuarios con base en edad y tiempo de uso y se observó cómo los miem- bros de la comunidad insertan la computadora en sus actividades cotidianas.AbstractThis research article is derived from a field study conducted to identify social representations (SR of the computer users of Community Learning Centers at ITESM. The instruments used were: free association test and interview script to samples of 217 subjects in the first condition and 31 in the sec- ond one. The study was conducted in Chapa de Mota and Villas del Carbón, Estado de México. SR were chang- ing between users based on age and length of use and showed how com- munity members used the computer in their daily activities.RésuméCet article de recherche découle d'une étude dans le terrain réalisée pour identifier les représentations sociales (RS de l’ordinateur chez les usagers des Centres Communautaires d’ap- prentissage dans le Tecnológico de Monterrey (Technologique de Mon- terrey. On a appliqué deux outils: la preuve d’association libre à 217 per- sonnes et le scenario d’entretien à 31 personnes. Les résultats ont montrés des représentations sociales chan- geantes en fonction de l’âge et le temps d’usage et on a observé com- ment les membres de la communauté utilisent l’ordinateur dans leurs activi- tés au quotidien.ResumoEste artigo se deriva de uma pesqui- sa de campo realizada

  11. Den eneste ene - hvordan etniske minoritetsunge i Danmark danner par

    DEFF Research Database (Denmark)

    Singla, Rashmi

    Rapporten handler om etniske unges måde at danne par på. Rapporten er baseret på en større empirisk undersøgelse gennemført af forfatteren i 2003 og er desuden inspireret af forfatterens egen ph.d.-afhandling: "Ungdom, etnicitet og psychosocial intervention" (2000, Københavns Universitet). Rappor...

  12. Parasitisme des champs semenciers de cacaoyers par les ...

    African Journals Online (AJOL)

    SARAH

    30 janv. 2015 ... J. Appl. Biosci. Parasitisme des champs semenciers de cacaoyers par les loranthaceae dans la localité de Nkoemvone (sud Cameroun). 7795 to the various clones, Phragmanthera capitata was the most abundant Loranthaceae; the level of parasitism of cacao trees is more important at the cacao trees of ...

  13. La lecture de Merleau-Ponty par Renaud Barbaras

    Czech Academy of Sciences Publication Activity Database

    Pechar, Jiří

    2015-01-01

    Roč. 11, č. 2 (2015), s. 1-6 ISSN 1336-6556 Institutional support: RVO:67985955 Keywords : Merleau-Ponty * Husserl * phenomenology * linguistics of Ferdinand de Saussure Subject RIV: AA - Philosophy ; Religion http://www.ostium.sk/sk/la-lecture-de-merleau-ponty-par-renaud-barbaras/

  14. Approximation point par point pour la resolution du probleme de ...

    African Journals Online (AJOL)

    Approximation point par point pour la resolution du probleme de dirichlet dans un disque pour l'equation elliptique du second ordre a coefficients constants dans le cas ou les racines de l'equation caracteristique sont distinctes. AMJ Tchalla, K Tcharie ...

  15. Parálisis Facial en Enfermedad de Lyme

    OpenAIRE

    Gilberto Eduardo Marrugo Pardo; Melissa Vargas Márquez

    2015-01-01

    Presentamos el caso de un paciente de 23 meses de edad quien desarrollo parálisis facial unilateral secundaria a Enfermedad de Lyme sin síntomas otológicos previos y en Colombia que es considerada área no endémica.

  16. Ankaferd Blood Stopper induces apoptosis and regulates PAR1 and ...

    African Journals Online (AJOL)

    Mine Mumcuoglu

    2014-12-16

    Dec 16, 2014 ... b. , Nejat Akar c a LOSEV the Foundation for Children with Leukemia, Cancer Genetics Research Laboratory, Ankara, Turkey b LOSEV the Foundation for Children with Leukemia, .... 2 × 106 cells were counted and seeded into 25 cm2 flasks. .... ports the idea that there is a link between increases in PAR1.

  17. Efficacite et tolerance du captopril par voie sublinguale dans la ...

    African Journals Online (AJOL)

    insuffisance rénale chronique étaient les deux principales causes d'échec thérapeutique. Conclusion : Le captopril par voie sublinguale est donc aussi efficace chez le noir africain que chez le caucasien. Dans le contexte de pays en voie de ...

  18. Priapisme induit par la chlorpromazine: A propos de deux cas

    Directory of Open Access Journals (Sweden)

    I. Marrag

    2016-06-01

    Le priapisme veineux est une urgence urologique. Il constitue un des effets secondaires des neuroleptiques parmi les quels la chlorpromazine. Cet effet iatrogène, qui est rare mais grave, doit être connu par les cliniciens afin d’être mieux prévenu pour éviter les séquelles érectiles.

  19. Indications and Visual Outcome of First Hundred Pars Plana ...

    African Journals Online (AJOL)

    tulyasys

    Objective: To review the indications and visual outcome of the first one hundred pars plana vitrectomies performed at the newly established ... pre and postoperative visual acuity, indication for surgery and associated systemic or ocular co-morbidities of first hundred ..... Source of Support: Nil, Conflict of Interest: None declared.

  20. Indications and visual outcome of first hundred pars plana ...

    African Journals Online (AJOL)

    Conclusion: Rhegmatogenous retinal detachment and vitreous hemorrhage are the major indications for pars plana vitrectomy in this environment. As vitreoretinal disorders have become more common in this part of the world, there would be a corresponding increase in demand for vitreoretinal services. There is therefore a ...

  1. Radiative transfer code: Application to the calculation of PAR

    Indian Academy of Sciences (India)

    solar radiation as vector flux rather than PAR leads to an underestimate of the primary production up to ... The production of carbon in the ocean, the so-called .... ments, bchla, are very difficult to measure experimen- tally. Usually, we use a bio-optical model to derive bchla from the concentration of chlorophyll ''a'' pigment.

  2. parC Mutations in Fluoroquinolone-Resistant Borrelia burgdorferi

    OpenAIRE

    Galbraith, Kendal M.; Ng, Amanda C.; Eggers, Betsy J.; Kuchel, Craig R.; Eggers, Christian H.; Samuels, D. Scott

    2005-01-01

    We have isolated in vitro fluoroquinolone-resistant mutants of the Lyme disease agent, Borrelia burgdorferi. Mutations in parC, which encodes a subunit of topoisomerase IV, were associated with loss of susceptibility to sparfloxacin, moxifloxacin, and Bay-Y3118, but not ciprofloxacin. This is the first description of fluoroquinolone resistance in the spirochete phylum.

  3. Parálisis Facial en Enfermedad de Lyme

    Directory of Open Access Journals (Sweden)

    Gilberto Eduardo Marrugo Pardo

    2015-01-01

    Full Text Available Presentamos el caso de un paciente de 23 meses de edad quien desarrollo parálisis facial unilateral secundaria a Enfermedad de Lyme sin síntomas otológicos previos y en Colombia que es considerada área no endémica.

  4. The Pars Triangularis in Dyslexia and ADHD: A Comprehensive Approach

    Science.gov (United States)

    Kibby, Michelle Y.; Kroese, Judith M.; Krebbs, Hillery; Hill, Crystal E.; Hynd, George W.

    2009-01-01

    Limited research has been conducted on the structure of the pars triangularis (PT) in dyslexia despite functional neuroimaging research finding it may play a role in phonological processing. Furthermore, research to date has not examined PT size in ADHD even though the right inferior frontal region has been implicated in the disorder. Hence, one…

  5. Apoplejía pituitaria con parálisis del III par craneal: Reporte de caso

    Directory of Open Access Journals (Sweden)

    Miguel Pinto Valdivia

    2011-10-01

    Full Text Available Se describe el caso de un varón de 65 años de edad, sin antecedentes patológicos de importancia, que acudió a emergencia del Hospital Nacional Cayetano Heredia por presentar cefalea intensa y ptosis palpebral izquierda. El examen físico mostró parálisis aislada del III par craneal izquierdo. Los análisis de laboratorio mostraron hiponatremia e hipopituitarismo y la resonancia magnética nuclear un adenoma pituitario con áreas de hemorragia e invasión de los senos cavernosos. El tratamiento incluyó glucocorticoides y descompresión quirúrgica transesfenoidal. La anatomía patológica confirmó el diagnóstico de infarto hemorrágico de un adenoma pituitario. El paciente fue dado de alta con terapia sustitutiva de levotiroxina y prednisona. La ptosis palpebral izquierda se recuperó en forma parcial. La apoplejía pituitaria es un síndrome clínico producido por un proceso expansivo dentro de la silla turca, secundario a hemorragia o infarto de un adenoma pituitario, que se caracteriza por cefalea, déficit visual, oftalmoplejía y alteración del nivel de conciencia. Este proceso expansivo puede comprimir los pares craneales en los senos cavernosos, produciendo diferentes grados de parálisis de los músculos oculomotores. La parálisis aislada del III par craneal es rara.(Rev Med Hered 2011;22:186-189.

  6. First (18)F-labeled ligand for PET imaging of uPAR

    DEFF Research Database (Denmark)

    Persson, Morten; Liu, Hongguang; Madsen, Jacob

    2013-01-01

    Urokinase-type plasminogen activator receptor (uPAR) is overexpressed in human prostate cancer and uPAR has been found to be associated with metastatic disease and poor prognosis. AE105 is a small linear peptide with high binding affinity to uPAR. We synthesized an N-terminal NOTA-conjugated vers...

  7. Nanomechanical recognition of prognostic biomarker suPAR with DVD-ROM optical technology

    DEFF Research Database (Denmark)

    Bache, Michael; Bosco, Filippo; Brøgger, Anna Line

    2013-01-01

    of soluble uPAR (suPAR) to infectious diseases, such as HIV, and certain types of cancer. Using hundreds of cantilevers and a DVD-based platform, cantilever deflection response from antibody–antigen recognition is investigated as a function of suPAR concentration. The goal is to provide a cheap and portable...

  8. Protease-Activated Receptor 4 (PAR4): A Promising Target for Antiplatelet Therapy.

    Science.gov (United States)

    Rwibasira Rudinga, Gamariel; Khan, Ghulam Jilany; Kong, Yi

    2018-02-14

    Cardiovascular diseases (CVDs) are currently among the leading causes of death worldwide. Platelet aggregation is a key cellular component of arterial thrombi and major cause of CVDs. Protease-activated receptors (PARs), including PAR1, PAR2, PAR3 and PAR4, fall within a subfamily of seven-transmembrane G-protein-coupled receptors (GPCR). Human platelets express PAR1 and PAR4, which contribute to the signaling transduction processes. In association with CVDs, PAR4 not only contributes to platelet activation but also is a modulator of cellular responses that serve as hallmarks of inflammation. Although several antiplatelet drugs are available on the market, they have many side effects that limit their use. Emerging evidence shows that PAR4 targeting is a safer strategy for preventing thrombosis and consequently may improve the overall cardiac safety profile. Our present review summarizes the PAR4 structural characteristics, activation mechanism, role in the pathophysiology of diseases and understanding the association of PAR4 targeting for improved cardiac protection. Conclusively, this review highlights the importance of PAR4 antagonists and its potential utility in different CVDs.

  9. Protease-Activated Receptor 4 (PAR4: A Promising Target for Antiplatelet Therapy

    Directory of Open Access Journals (Sweden)

    Gamariel Rwibasira Rudinga

    2018-02-01

    Full Text Available Cardiovascular diseases (CVDs are currently among the leading causes of death worldwide. Platelet aggregation is a key cellular component of arterial thrombi and major cause of CVDs. Protease-activated receptors (PARs, including PAR1, PAR2, PAR3 and PAR4, fall within a subfamily of seven-transmembrane G-protein-coupled receptors (GPCR. Human platelets express PAR1 and PAR4, which contribute to the signaling transduction processes. In association with CVDs, PAR4 not only contributes to platelet activation but also is a modulator of cellular responses that serve as hallmarks of inflammation. Although several antiplatelet drugs are available on the market, they have many side effects that limit their use. Emerging evidence shows that PAR4 targeting is a safer strategy for preventing thrombosis and consequently may improve the overall cardiac safety profile. Our present review summarizes the PAR4 structural characteristics, activation mechanism, role in the pathophysiology of diseases and understanding the association of PAR4 targeting for improved cardiac protection. Conclusively, this review highlights the importance of PAR4 antagonists and its potential utility in different CVDs.

  10. Design, construction, and wire calibration of PAR BPM striplines

    International Nuclear Information System (INIS)

    Sellyey, W.; Barr, D.; Erwin, L.

    1994-01-01

    The Positron Accumulator Ring (PAR) is part of the APS injection system. It receives 24 30-ns FWHM bursts of 450-MeV positrons, and compresses them into 6-nC, 290-ps rms bunches. Striplines were selected as beam position monitors (BPMs) to assure that good position sensitivity is achieved. This paper will describe the design, construction, and wire calibration of the 16 PAR BPMs. It will be demonstrated that all relevant stripline parameters can be determined by solving the two-dimensional LaPlace equation. This was done numerically using the electrostatic part of the PE2D computer program. The construction of the units will be briefly discussed. Wire calibration data on one of the final units will be compared with theory at four frequencies

  11. A Pipeline for PAR-CLIP Data Analysis.

    Science.gov (United States)

    Jens, Marvin

    2016-01-01

    Photo-activatable ribonucleoside cross-linking and immunoprecipitation (PAR-CLIP) is a method to detect binding sites of RNA-binding proteins (RBPs) transcriptome-wide. This chapter covers the computational analysis of the high-throughput sequencing reads generated from PAR-CLIP experiments. It explains how the reads are mutated due to UV cross-linking and how to appropriately pre-process and align them to a reference sequence. Aligned reads are then aggregated into clusters which represent putative RBP-binding sites. Mapping artifacts are a source of false positives, which can be controlled by means of a mapping decoy and adaptive quality filtering of the read clusters. A step-by-step explanation of this procedure is given. All necessary tools are open source, including the scripts presented and used in this chapter.

  12. Démarginalisation des travailleurs pauvres par le droit | CRDI ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Démarginalisation des travailleurs pauvres par le droit. Cette subvention appuiera une étude approfondie de la situation, des revendications et des combats juridiques des travailleurs pauvres (plus particulièrement des femmes) membres de l'économie non structurée au Ghana, au Pérou et en Thaïlande. On aura recours à ...

  13. Contribution de la tomographie par coherence optique au diagnostic ...

    African Journals Online (AJOL)

    La tomographie par cohérence optique (OCT) est devenue un outil diagnostique très important en neurophtalmologie. Dans un grand nombre de cas, le profil OCT apporte à la fois une aide diagnostique et une évaluation de l'importance de la neuropathie optique. Parmi les étiologies de la neuropathie optique, il y a la ...

  14. Inondations dans la banlieue de Dakar : vers une adaptation par ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Inondations dans la banlieue de Dakar : vers une adaptation par des améliorations du bâti, des infrastructures et de la gouvernance locale. La gestion des inondations représente un des défis majeurs du continent africain en regard des changements climatiques. Une urbanisation effrénée, un étalement urbain hors de ...

  15. Traitement De La Peripneumonie Contagieuse Bovine Par L ...

    African Journals Online (AJOL)

    Traitement De La Peripneumonie Contagieuse Bovine Par L'oxyteTracycline Longe Action Et Transmission Experimentale de la Maladie A Partir de Bovins Traites. ... Tous les 14 animaux ont séroconverti et l'analyse post-mortem a montré la présence des lésions chroniques dont des séquestres pulmonaires chez 4 d'entre ...

  16. Candido: Uma Leitura Paródica de Candide

    Directory of Open Access Journals (Sweden)

    Maria Gloria Cusumano Mazzi

    2010-12-01

    Full Text Available O presente artigo estuda a leitura paródica que Leonardo Sciascia (1921-1989 faz de Voltaire (1694-1778 mediante o cotejo das obras: o hipertexto Candido ovvero Un sogno fatto in Sicilia (1977 e o hipotexto Candide ou l’optimisme (1759. Apresenta ainda outra possibilidade de leitura, ou seja, Candido como metáfora da própria intertextualidade.

  17. Solution volumes finis polynomiale par morceaux pour les ...

    African Journals Online (AJOL)

    Nous présentons dans ce papier un concept de solution volumes finis continue pour des problèmes de diffusion-convection avec des données régulières. Nous comparons dans certains cas particuliers la solution proposée avec la solution volumes finis classiques (qui est une fonction constante par morceaux) et la ...

  18. Epuration des effluents industriels par électroflottation Belkacem ...

    African Journals Online (AJOL)

    d'absorption atomique SAA (Shimadzu,. Japan) [26,27]. 3. RESULTATS ET DISCUSSIONS. En électroflottation avec des électrodes en aluminium, l'anode émet les ions Al3+. , causant la neutralisation de la charge extérieure des particules (du potentiel zêta) dans l'eau. La cathode produit le gaz. H2. (par électrolyse), ayant ...

  19. Tuberculose lymphonodale cervicale chez les enfants vaccines par ...

    African Journals Online (AJOL)

    La tuberculose ganglionnaire cervicale est une localisation extrapulmonaire relativement fréquente chez l'enfant. Elle pose essentiellement des difficultés de prévention. L'objectif de ce travail est d'étudier les particularités diagnostiques et thérapeutiques chez des enfants vaccinés par le BCG. Matériel et méthodes: Nôtre ...

  20. La parálisis cerebral en el contexto escolar /

    OpenAIRE

    Rodríguez Gimeno, Ignacio

    2012-01-01

    Se analiza el concepto de parálisis cerebral, los diferentes tipos y sus características. También las adaptaciones que se deben realizar a nivel de centro, de aula, y a nivel individual para estos alumnos, conocer los diferentes sistemas alternativos y aumentativos de comunicación y aplicar las ayudas técnicas que precisa este alumnado

  1. MYRINGOPLASTIE PAR LA TECHNIQUE DES BOUTONNIÈRES

    African Journals Online (AJOL)

    Le but de ce travail est de rapporter nos résultatsde myringoplastie par la technique des boutonnières, chez des patients porteurs ... (4,08%), la latéralisation dans 1 cas (2,04%), le blunting ou comblement de l'angle antérieur tympano-méatal dans 1 cas. (2,04%) ..... permettent qu'un contact limité entre le greffon et les reli-.

  2. Adoption d'innovations agricoles par le truchement de services ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    L'agriculture est le fer de lance de nombreuses économies en développement, mais la capacité des petits agriculteurs privés de ressources à adopter des innovations agricoles est freinée par le manque d'accès à des services financiers adéquats. Des experts internationaux estiment qu'il existe un manque à gagner ...

  3. Facteurs predictifs de mortalite par accident vasculaire cerebral ...

    African Journals Online (AJOL)

    Description Les AVC constituent un problème de santé publique avec une mortalité élevée. Objectif Identifier les facteurs prédictifs de mortalité par accidents vasculaires cérébraux à la Clinique Neurologique du CHU de Fann, Dakar. Méthodes Il s'agit d'une étude rétrospective du 1er Janvier 2001 au 01 Novembre 2003 ...

  4. Protease activated receptors (PARS) mediation in gyroxin biological activity

    International Nuclear Information System (INIS)

    Silva, Jose Alberto Alves da

    2009-01-01

    Gyroxin is a serine protease enzyme from the South American rattlesnake (Crotalus durissus terrificus) venom; it is only partially characterized and has multiple activities. Gyroxin induces blood coagulation, blood pressure decrease and a neurotoxic behavior named barrel rotation. The mechanisms involved in this neurotoxic activity are not known. Whereas gyroxin is a member of enzymes with high potential to become a new drug with clinical applications such as thrombin, batroxobin, ancrod, tripsyn and kalicrein, it is important to find out how gyroxin works. The analysis on agarose gel electrophoresis and circular dichroism confirmed the molecules' integrity and purity. The gyroxin intravenous administration in mice proved its neurotoxicity (barrel rotation). In vivo studies employing intravital microscopy proved that gyroxin induces vasodilation with the participation of protease activated receptors (PARs), nitric oxide and Na+K+ATPase. The leukocytes' adherence and rolling counting indicated that gyroxin has no pro inflammatory activity. Gyroxin induced platelet aggregation, which was blocked by inhibitors of PAR1 and PAR4 receptors (SCH 79797 and tcY-NH 2 , respectively). Finally, it was proved that the gyroxin temporarily alter the permeability of the blood brain barrier (BBB). Our study has shown that both the protease-activated receptors and nitric oxide are mediators involved in the biological activities of gyroxin. (author)

  5. La modélisation par Reverse Monte Carlo (RMC)

    Science.gov (United States)

    McGreevy, R. L.

    2003-09-01

    La technique de modélisation par Reverse Monte Carlo (RMC) est une méthode générale de modélisation structurale à partir d'un ensemble de données expérimentales. Cette méthode étant très souple, elle peut s'appliquer à de nombreux types de données. Jusqu'à présent ces applications comprennent : la diffraction des neutrons (y compris la substitution isotopique), la diffraction des rayons X (y compris la diffusion anomale), la diffraction des électrons, la RMN (les techniques d'angle magique et de 2ème moment) et l'EXAFS. Les systèmes étudiés sont également d'une grande variété : liquides, verres, polymères, cristaux et matériaux magnétiques, par exemple. Ce cours présente les bases de la méthode RMC en signalant certaines des idées fausses répandues. L'accent sera mis sur le fait que les modèles structuraux obtenus par RMC ne sont ni'uniques' ni 'exacts' ; cependant ils sont souvent utiles à la compréhension soit de la structure du système, soit des relations entre structure et autres propriétés physiques.

  6. Macroinvertebrates of Par Pond and Pond B: Final report, January 1984-June 1985

    Energy Technology Data Exchange (ETDEWEB)

    Kondratieff, B.C.; Chimney, M.J.; Painter, W.B.

    1985-08-01

    This document reports on the Par Pond and Pond B macroinvertebrate sampling program from January 1984 through June 1985. It includes data on quantitative and qualitative benthic sampling, quantitative meroplankton sampling and quarterly diel sample. The basic objectives were to: (1) characterize the benthic and meroplankton macroinvertebrate communities of Par Pond and Pond B, with respect to taxonomic composition and diversity, density and relative abundance of functional feeding groups; (2) assess the impact of thermal discharges on the macroinvertebrate community of Par Pond; (3) assess the impact and significance of entrainment losses of macroinvertebrate meroplankton from Par Pond; and (4) compare Par Pond macroninvertebrate communities with those in Pond B.

  7. Expression of Partitioning Defective 3 (Par-3 for Predicting Extrahepatic Metastasis and Survival with Hepatocellular Carcinoma

    Directory of Open Access Journals (Sweden)

    Jun-Yang Liou

    2013-01-01

    Full Text Available Partitioning defective 3 (Par-3, a crucial component of partitioning-defective complex proteins, controls cell polarity and contributes to cell migration and cancer cell epithelial-to-mesenchymal transition. However, the clinical relevance of Par-3 in tumor progression and metastasis has not been well elucidated. In this study, we investigated the impact and association of Par-3 expression and clinical outcomes with hepatocellular carcinoma (HCC. We first confirmed that Par-3 was abundantly expressed in HCC cell lines by Western blot analysis. We used immunohistochemistry to analyze the association of Par-3 expression and clinicopathological characteristics in primary and subsequent metastatic tumors of patients with HCC. Par-3 was overexpressed in 47 of 111 (42.3% primary tumors. Increased expression of Par-3 in primary tumors predicted an increased five-year cumulative incidence of extrahepatic metastasis. In addition, multivariate analysis revealed that Par-3 overexpression was an independent risk factor of extrahepatic metastasis. Increased Par-3 expression in primary tumors was associated with poor five-year overall survival rates and was an independent prognostic factor on Cox regression analysis. In conclusion, we show for the first time that increased Par-3 expression is associated with distant metastasis and poor survival rates in patients with HCC. Par-3 may be a novel prognostic biomarker and therapeutic target for HCC.

  8. Proteinase-Activated Receptor 1 (PAR1) regulates leukemic stem cell functions.

    Science.gov (United States)

    Bäumer, Nicole; Krause, Annika; Köhler, Gabriele; Lettermann, Stephanie; Evers, Georg; Hascher, Antje; Bäumer, Sebastian; Berdel, Wolfgang E; Müller-Tidow, Carsten; Tickenbrock, Lara

    2014-01-01

    External signals that are mediated by specific receptors determine stem cell fate. The thrombin receptor PAR1 plays an important role in haemostasis, thrombosis and vascular biology, but also in tumor biology and angiogenesis. Its expression and function in hematopoietic stem cells is largely unknown. Here, we analyzed expression and function of PAR1 in primary hematopoietic cells and their leukemic counterparts. AML patients' blast cells expressed much lower levels of PAR1 mRNA and protein than CD34+ progenitor cells. Constitutive Par1-deficiency in adult mice did not affect engraftment or stem cell potential of hematopoietic cells. To model an AML with Par1-deficiency, we retrovirally introduced the oncogene MLL-AF9 in wild type and Par1-/- hematopoietic progenitor cells. Par1-deficiency did not alter initial leukemia development. However, the loss of Par1 enhanced leukemic stem cell function in vitro and in vivo. Re-expression of PAR1 in Par1-/- leukemic stem cells delayed leukemogenesis in vivo. These data indicate that Par1 contributes to leukemic stem cell maintenance.

  9. Proteinase-Activated Receptor 1 (PAR1 regulates leukemic stem cell functions.

    Directory of Open Access Journals (Sweden)

    Nicole Bäumer

    Full Text Available External signals that are mediated by specific receptors determine stem cell fate. The thrombin receptor PAR1 plays an important role in haemostasis, thrombosis and vascular biology, but also in tumor biology and angiogenesis. Its expression and function in hematopoietic stem cells is largely unknown. Here, we analyzed expression and function of PAR1 in primary hematopoietic cells and their leukemic counterparts. AML patients' blast cells expressed much lower levels of PAR1 mRNA and protein than CD34+ progenitor cells. Constitutive Par1-deficiency in adult mice did not affect engraftment or stem cell potential of hematopoietic cells. To model an AML with Par1-deficiency, we retrovirally introduced the oncogene MLL-AF9 in wild type and Par1-/- hematopoietic progenitor cells. Par1-deficiency did not alter initial leukemia development. However, the loss of Par1 enhanced leukemic stem cell function in vitro and in vivo. Re-expression of PAR1 in Par1-/- leukemic stem cells delayed leukemogenesis in vivo. These data indicate that Par1 contributes to leukemic stem cell maintenance.

  10. Nuclear movement during myotube formation is microtubule and dynein dependent and is regulated by Cdc42, Par6 and Par3

    OpenAIRE

    Cadot, Bruno; Gache, Vincent; Vasyutina, Elena; Falcone, Sestina; Birchmeier, Carmen; Gomes, Edgar R

    2012-01-01

    Mono-nucleated myoblasts fuse to form multi-nucleated myotubes. After the fusion, the myoblast nucleus moves towards the centre of the myotube. This movement is driven by microtubules and dynein, and is regulated by Cdc42, Par6 and Par3.

  11. The double par locus of virulence factor pB171: DNA segregation is correlated with oscillation of ParA

    DEFF Research Database (Denmark)

    Ebersbach, G; Gerdes, K; Charbon, Gitte Ebersbach

    2001-01-01

    Prokaryotic plasmids and chromosomes encode partitioning (par) loci that segregate DNA to daughter cells before cell division. Recent database analyses showed that almost all known par loci encode an ATPase and a DNA-binding protein, and one or more cis-acting regions where the proteins act. All ...

  12. The double par locus of virulence factor pB171: DNA segregation is correlated with oscillation of ParA

    DEFF Research Database (Denmark)

    Ebersbach, G; Gerdes, K; Charbon, Gitte Ebersbach

    2001-01-01

    Prokaryotic plasmids and chromosomes encode partitioning (par) loci that segregate DNA to daughter cells before cell division. Recent database analyses showed that almost all known par loci encode an ATPase and a DNA-binding protein, and one or more cis-acting regions where the proteins act. All...

  13. African Journal of Neurological Sciences - 2009 Vol. 28 No 1

    African Journals Online (AJOL)

    développement de la chirurgie minimale invasive la voie endonasale par endoscopie avec ou sans guidage par navigation assistée par ordinateur se développe (4, 15). Elle est plus conservatrice et moins agressive élargissant les voies de drainage habituelles en respectant la muqueuse non tumorale. Mais il existe des.

  14. Serum suPAR in patients with FSGS: trash or treasure?

    Science.gov (United States)

    Maas, Rutger J H; Deegens, Jeroen K J; Wetzels, Jack F M

    2013-07-01

    The urokinase-type plasminogen activator receptor (uPAR) has important functions in cell migration. uPAR can be shed from the cell membrane resulting in soluble uPAR (suPAR). Further cleavage gives rise to shorter fragments with largely unknown functions. Recent studies have demonstrated that both overexpression of uPAR on podocytes and the administration of suPAR cause proteinuria in mice. The common pathogenic mechanism involves the activation of podocyte β3-integrin. Increased activation of β3-integrin is also observed in patients with focal and segmental glomerulosclerosis (FSGS). These observations form the basis for the hypothesis that suPAR may be the circulating factor causing FSGS. A recent study fosters this idea by demonstrating increased suPAR levels in the serum of patients with FSGS and reporting an association with recurrence after transplantation and response to plasmapheresis. However, this study was heavily biased, and subsequent studies have given conflicting results. Although the experimental work is very suggestive, at present there is no proof that any known human suPAR fragment causes FSGS in humans. We therefore suggest that the measurement of suPAR using currently available assays has absolutely no value at the present time in decision-making in routine clinical practice.

  15. Structures of actin-like ParM filaments show architecture of plasmid-segregating spindles.

    Science.gov (United States)

    Bharat, Tanmay A M; Murshudov, Garib N; Sachse, Carsten; Löwe, Jan

    2015-07-02

    Active segregation of Escherichia coli low-copy-number plasmid R1 involves formation of a bipolar spindle made of left-handed double-helical actin-like ParM filaments. ParR links the filaments with centromeric parC plasmid DNA, while facilitating the addition of subunits to ParM filaments. Growing ParMRC spindles push sister plasmids to the cell poles. Here, using modern electron cryomicroscopy methods, we investigate the structures and arrangements of ParM filaments in vitro and in cells, revealing at near-atomic resolution how subunits and filaments come together to produce the simplest known mitotic machinery. To understand the mechanism of dynamic instability, we determine structures of ParM filaments in different nucleotide states. The structure of filaments bound to the ATP analogue AMPPNP is determined at 4.3 Å resolution and refined. The ParM filament structure shows strong longitudinal interfaces and weaker lateral interactions. Also using electron cryomicroscopy, we reconstruct ParM doublets forming antiparallel spindles. Finally, with whole-cell electron cryotomography, we show that doublets are abundant in bacterial cells containing low-copy-number plasmids with the ParMRC locus, leading to an asynchronous model of R1 plasmid segregation.

  16. Envenimation mortelle par morsure de serpent chez une femme ...

    African Journals Online (AJOL)

    Les auteurs rapportent un cas de morsure de serpent au niveau de la face chez une femme enceinte, dont l'évolution a été marquée par l'installation d'un oedème cervico-facial nécessitant une trachéotomie en urgence, et une mort foetale in utero avec troubles de l'hémostase responsable du décès maternel dans un ...

  17. Hemangioma capilar de la parótida. Abordaje transoral

    OpenAIRE

    Sarra, Luis Domingo; Rodríguez, Juan Carlos; San Martino, Julio Alberto

    2014-01-01

    Los hemangiomas de la parótida son frecuentes en niños, representando aproximadamente el 50% de los tumores de dicha glándula durante el primer año de vida. Como contrapartida, estos tumores vasculares son extremadamente raros en pacientes adultos y solo se publican unos pocos casos aislados en la literatura, donde se mencionan las dificultades en el diagnóstico diferencial con los tumores primarios de las glándulas salivales. Presentamos un caso en una paciente adulta que consultó por una...

  18. Cartographie par carroyage et précision spatiale

    Directory of Open Access Journals (Sweden)

    Patrice LANGLOIS

    1998-03-01

    Full Text Available Dans le cadre d'une cartographie par carroyage, on étudie la désagrégation de variables zonales, en revenant sur l'hypothèse de l'équirépartition spatiale des populations. L'objectif est d'approcher des règles différenciées de désagrégation des variables en fusionnant des plans d'information de nature morphologique, topologique et environnementale.

  19. David Kasner, MD, and the Road to Pars Plana Vitrectomy

    Directory of Open Access Journals (Sweden)

    Christopher F. Blodi

    2016-01-01

    Full Text Available David Kasner, MD (1927–2001, used his extensive dissections of eye bank eyes and experiences in teaching cataract surgery to resident physicians to realize that excision of vitreous when present in the anterior chamber of eyes undergoing cataract surgery was preferable to prior intraoperative procedures. Noting that eyes tolerated his maneuvers, he then performed planned subtotal open-sky vitrectomies; first on a traumatized eye in 1961, then on two eyes of patients with amyloidosis (1966–1967. The success of these operations was noted by others, most particularly Robert Machemer, MD. Kasner's work directly led to further surgical developments, including closed pars plana vitrectomy.

  20. Predicting spectral and PAR light attenuation in Greenlandic coastal waters

    DEFF Research Database (Denmark)

    Murray, Ciarán; Markager, Stiig; Stedmon, Colin

    The spectral quality and penetration of light are key parameters controlling the productivity of Greenlandic fjords. Solar elevation and sea ice play an important role, but during the increasing ice free period and summer months in particular, light is also regulated by water constituents. We...... (CDOM), phytoplankton pigments and inorganic particles. These differences are due in part to hydrography and to the sources of meltwater: respectively, fjord-terminating and land-terminating glaciers. We present a model to explain the variation in spectral and PAR irradiance in terms of the variation...

  1. fortification des farines tropicales par l'introduction de proteines ...

    African Journals Online (AJOL)

    chiches, fève et haricot commun) est améliorée par l'extrusion. L'amidon de niébé extrudé à 180. °C possède une meilleure digestibilité que celui de niébé cru. CONCLUSION. Ce travail visait principalement la diversification des produits alimentaires à partir d'un mélange de farines de céréales locales, de légumineuses.

  2. Uveal neovascularization at the ora serrata and pars plana.

    Science.gov (United States)

    Kaba, F; el Baba, F; Green, W R

    1987-03-01

    Thirty-two eyes with uveal neovascularization at the ora serrata and pars plana were studied histopathologically. Chronic retinal detachment of various etiologies was the most frequently associated feature, present in 65% of the patients. In three eyes, the neovascularization took the form of an angiomatous lesion, whereas in the others, capillaries, arterioles, and venules were present. A history of glaucoma was found in 60% of the patients. Other associated findings included choroidal rupture, vitreous hemorrhage, and a history of cryotherapy. Uveal neovascularization at the ora serrata should be considered in the differential diagnosis of retinal angiomas, retinal telangiectasia, malignant melanoma, adult Coats's disease, peripheral proliferative retinopathies, and vitreous hemorrhage.

  3. Par-4-mediated recruitment of Amida to the actin cytoskeleton leads to the induction of apoptosis

    International Nuclear Information System (INIS)

    Boosen, Meike; Vetterkind, Susanne; Koplin, Ansgar; Illenberger, Susanne; Preuss, Ute

    2005-01-01

    Par-4 (prostate apoptosis response-4) sensitizes cells to apoptotic stimuli, but the exact mechanisms are still poorly understood. Using Par-4 as bait in a yeast two-hybrid screen, we identified Amida as a novel interaction partner, a ubiquitously expressed protein which has been suggested to be involved in apoptotic processes. Complex formation of Par-4 and Amida occurs in vitro and in vivo and is mediated via the C-termini of both proteins, involving the leucine zipper of Par-4. Amida resides mainly in the nucleus but displays nucleo-cytoplasmic shuttling in heterokaryons. Upon coexpression with Par-4 in REF52.2 cells, Amida translocates to the cytoplasm and is recruited to actin filaments by Par-4, resulting in enhanced induction of apoptosis. The synergistic effect of Amida/Par-4 complexes on the induction of apoptosis is abrogated when either Amida/Par-4 complex formation or association of these complexes with the actin cytoskeleton is impaired, indicating that the Par-4-mediated relocation of Amida to the actin cytoskeleton is crucial for the pro-apoptotic function of Par-4/Amida complexes in REF52.2 cells. The latter results in enhanced phosphorylation of the regulatory light chain of myosin II (MLC) as has previously been shown for Par-4-mediated recruitment of DAP-like kinase (Dlk), suggesting that the recruitment of nuclear proteins involved in the regulation of apoptotic processes to the actin filament system by Par-4 represents a potent mechanism how Par-4 can trigger apoptosis

  4. Decreased Expression of the Polarity Regulatory PAR Complex Predicts Poor Prognosis of the Patients with Colorectal Adenocarcinoma

    Directory of Open Access Journals (Sweden)

    Min-Kyung Yeo

    2018-02-01

    Full Text Available Partitioning defective (Par proteins regulate cell polarity and differentiation. Par3, Par6β, and protein kinase Cζ (PKCζ, which are PAR complex members, have been shown to be associated with oncogenesis and progression. Herein, we report the expression pattern and clinical relevance of Par3, Par6β, and PKCζ in colorectal adenocarcinoma (CRAC. A total of 393 primary CRACs, 41 primary-metastatic CRAC pairs, 41 adenomas with low-grade dysplasia, and 41 nontumor colorectal tissue samples were examined by immunohistochemistry and Western blot assays for Par3, Par6β, and PKCζ protein expressions. The association Par3, Par6β, and PKCζ expressions and clinicopathologic factors, including patient survival, was evaluated. Primary CRACs and adenomas demonstrated higher levels of Par3, Par6β, and PKCζ than in nontumor colorectal epithelia. The expressions of Par3, Par6β, and PKCζ were higher in primary CRACs as compared to adenomas or in metastatic CRACs. Among primary CRACs, decreased Par3 expression was found to correlate with a high proliferation rate and poor histologic differentiation, decreased PKCζ expression was correlated with pathologic TNM stage (I-II vs III-IV and lymph node metastasis, and decreased Par6β and PKCζ expressions were correlated with shortened overall survivals. In metastatic CRACs, decreased PKCζ expression was correlated with a shortened metastasis-free survival. While increased Par3, Par6β, and PKCζ expressions were implicated in tumorigenesis, decreased expressions of Par3, Par6β, and PKCζ were found to be associated with worse clinicopathologic factors in CRAC. In particular, the results of our study suggest that PKCζ down-expression is an independent poor prognostic and metastatic factor for CRAC.

  5. PhyloPars: estimation of missing parameter values using phylogeny.

    Science.gov (United States)

    Bruggeman, Jorn; Heringa, Jaap; Brandt, Bernd W

    2009-07-01

    A wealth of information on metabolic parameters of a species can be inferred from observations on species that are phylogenetically related. Phylogeny-based information can complement direct empirical evidence, and is particularly valuable if experiments on the species of interest are not feasible. The PhyloPars web server provides a statistically consistent method that combines an incomplete set of empirical observations with the species phylogeny to produce a complete set of parameter estimates for all species. It builds upon a state-of-the-art evolutionary model, extended with the ability to handle missing data. The resulting approach makes optimal use of all available information to produce estimates that can be an order of magnitude more accurate than ad-hoc alternatives. Uploading a phylogeny and incomplete feature matrix suffices to obtain estimates of all missing values, along with a measure of certainty. Real-time cross-validation provides further insight in the accuracy and bias expected for estimated values. The server allows for easy, efficient estimation of metabolic parameters, which can benefit a wide range of fields including systems biology and ecology. PhyloPars is available at: http://www.ibi.vu.nl/programs/phylopars/.

  6. Stress reactions involving the pars interarticularis in young athletes

    International Nuclear Information System (INIS)

    Jackson, D.W.; Wiltse, L.L.; Dingeman, R.D.; Hayes, M.

    1981-01-01

    A stress reaction involving the pars interarticularis of the lumbar spine was confirmed in seven young athletes with a positive technetium pyrophosphate bone scan. No pars defects were detectable on their lumbosacral roentgenograms, which included oblique views. The return to normal levels of radioactive uptake on repeat bone scans correlated closely with their clinical course. If the bony reaction is recognized early, it may heal at a subroentgenographic level and prevent the development of lumbar spondylolysis. These early lesions usually show unilateral increased uptake at one lumbar level on the bone scan and, initially, the athlete localizes the pain to the corresponding unilateral lumbar paraspinous area. The ''one-legged hyperextension test'' is positive on the ipsilateral side and aggravates the pain. Treatment consists of avoiding the aggravating activities and resting. The average time for return to pain-free competition was 7.3 months. These developing defects may be the source of considerable prolonged disability in the young athlete, particularly if undiagnosed and untreated

  7. Stress reactions involving the pars interarticularis in young athletes

    Energy Technology Data Exchange (ETDEWEB)

    Jackson, D.W.; Wiltse, L.L.; Dingeman, R.D.; Hayes, M.

    A stress reaction involving the pars interarticularis of the lumbar spine was confirmed in seven young athletes with a positive technetium pyrophosphate bone scan. No pars defects were detectable on their lumbosacral roentgenograms, which included oblique views. The return to normal levels of radioactive uptake on repeat bone scans correlated closely with their clinical course. If the bony reaction is recognized early, it may heal at a subroentgenographic level and prevent the development of lumbar spondylolysis. These early lesions usually show unilateral increased uptake at one lumbar level on the bone scan and, initially, the athlete localizes the pain to the corresponding unilateral lumbar paraspinous area. The ''one-legged hyperextension test'' is positive on the ipsilateral side and aggravates the pain. Treatment consists of avoiding the aggravating activities and resting. The average time for return to pain-free competition was 7.3 months. These developing defects may be the source of considerable prolonged disability in the young athlete, particularly if undiagnosed and untreated.

  8. Paracrine Apoptotic Effect of p53 Mediated by Tumor Suppressor Par-4

    Directory of Open Access Journals (Sweden)

    Ravshan Burikhanov

    2014-01-01

    Full Text Available The guardian of the genome, p53, is often mutated in cancer and may contribute to therapeutic resistance. Given that p53 is intact and functional in normal tissues, we harnessed its potential to inhibit the growth of p53-deficient cancer cells. Specific activation of p53 in normal fibroblasts selectively induced apoptosis in p53-deficient cancer cells. This paracrine effect was mediated by p53-dependent secretion of the tumor suppressor Par-4. Accordingly, the activation of p53 in normal mice, but not p53−/− or Par-4−/− mice, caused systemic elevation of Par-4, which induced apoptosis of p53-deficient tumor cells. Mechanistically, p53 induced Par-4 secretion by suppressing the expression of its binding partner, UACA, which sequesters Par-4. Thus, normal cells can be empowered by p53 activation to induce Par-4 secretion for the inhibition of therapy-resistant tumors.

  9. Réduction du risque d'infection par le VIH au Botswana - essais ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Au Botswana, ce sont les jeunes femmes qui sont le plus touchées par les nouvelles infections par le VIH. Le présent projet a pour but de réduire le nombre de nouveaux cas d'infection par le VIH, en particulier chez les femmes de 15 à 29 ans. Bien que l'on recense des cas de VIH/sida dans la plupart des régions du ...

  10. Une révolution numérique dans les salles de classe de l'Uruguay ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    28 janv. 2011 ... Surnommé le « XO », cet ordinateur robuste a été présenté au Sommet mondial sur la société de l'information en novembre 2005 par Nicholas Negroponte, fondateur d'OLPC et créateur du Media Lab du Massachusetts Institute of Technology. On a pu réduire le coût de l'ordinateur à environ 100 USD en ...

  11. Magnetic activity and radial velocity filtering of young Suns: the weak-line T-Tauri stars Par 1379 and Par 2244

    Science.gov (United States)

    Hill, C. A.; Carmona, A.; Donati, J.-F.; Hussain, G. A. J.; Gregory, S. G.; Alencar, S. H. P.; Bouvier, J.; The Matysse Collaboration

    2017-12-01

    We report the results of our spectropolarimetric monitoring of the weak-line T-Tauri stars (wTTSs) Par 1379 and Par 2244, within the MaTYSSE (Magnetic Topologies of Young Stars and the Survival of close-in giant Exoplanets) programme. Both stars are of a similar mass (1.6 and 1.8 M⊙) and age (1.8 and 1.1 Myr), with Par 1379 hosting an evolved low-mass dusty circumstellar disc, and with Par 2244 showing evidence of a young debris disc. We detect profile distortions and Zeeman signatures in the unpolarized and circularly polarized lines for each star, and have modelled their rotational modulation using tomographic imaging, yielding brightness and magnetic maps. We find that Par 1379 harbours a weak (250 G), mostly poloidal field tilted 65° from the rotation axis. In contrast, Par 2244 hosts a stronger field (860 G) split 3:2 between poloidal and toroidal components, with most of the energy in higher order modes, and with the poloidal component tilted 45° from the rotation axis. Compared to the lower mass wTTSs, V819 Tau and V830 Tau, Par 2244 has a similar field strength, but is much more complex, whereas the much less complex field of Par 1379 is also much weaker than any other mapped wTTS. We find moderate surface differential rotation of 1.4× and 1.8× smaller than Solar, for Par 1379 and Par 2244, respectively. Using our tomographic maps to predict the activity-related radial velocity (RV) jitter, and filter it from the RV curves, we find RV residuals with dispersions of 0.017 and 0.086 km s-1 for Par 1379 and Par 2244, respectively. We find no evidence for close-in giant planets around either star, with 3σ upper limits of 0.56 and 3.54 MJup (at an orbital distance of 0.1 au).

  12. Effect of a physical activity intervention on suPAR levels

    DEFF Research Database (Denmark)

    Rohde, Christopher; Polcwiartek, Christoffer; Andersen, Eivind

    2018-01-01

    OBJECTIVES: Soluble urokinase-type plasminogen activator receptor (suPAR) is a novel inflammatory marker, associated with lifestyle diseases and mortality risk. No studies have investigated whether physical activity may reduce suPAR levels using a randomized controlled design. DESIGN AND METHODS:.......219-0.215). Similar results were found for CRP levels. CONCLUSION: There was no change in suPAR levels after regular exercise compared to a control group implying that suPAR rather reflects underlying harmful inflammatory responses associated with disease development....

  13. IGF-II receptors in luminal and basolateral membranes isolated from pars convoluta and pars recta of rabbit proximal tubule

    DEFF Research Database (Denmark)

    Jacobsen, Christian; Jessen, H; Flyvbjerg, A

    1995-01-01

    The binding of 125I-labeled insulin-like growth factor-II (125I-IGF-II) to luminal and basolateral membrane vesicles isolated from pars convoluta and the straight part (pars recta) of rabbit proximal tubule was investigated. Analyses of the binding data by use of the general stoichiometric binding...... equation revealed, that in all preparations IGF-II was bound to one high-affinity binding site and other sites with lower affinities. The specificity of the high-affinity 125I-IGF-II binding to the membrane vesicles assessed by displacement by unlabeled IGF-II, IGF-I and insulin showed that IGF-I displaced...... 125I-IGF-II in the range 22.5-47.9 nM (IC50) whereas insulin did not effect 125I-IGF-II binding at all. beta-Galactosidase inhibited the 125I-IGF-II binding with half-maximal inhibition of 20-30 nM beta-galactosidase. D-Mannose 6-phosphate increased the binding of 125I-IGF-II and reversed...

  14. Patterns of axonal branching of neurons of the substantia nigra pars reticulata and pars lateralis in the rat.

    Science.gov (United States)

    Cebrián, Carolina; Parent, André; Prensa, Lucía

    2005-11-21

    Axons from neurons of the rat substantia nigra pars reticulata (SNr) and pars lateralis (SNl) were traced after injecting their cell body with biotinylated dextran amine. Thirty-two single axons were reconstructed from serial sagittal sections with a camera lucida, whereas four other SNr axons were reconstructed in the coronal plane to determine whether they innervate the contralateral hemisphere. Four distinct types of SNr projection neurons were identified based on their main axonal targets: type I neurons that project to the thalamus; type II neurons that target the thalamus, the superior colliculus (SC), and the pedunculopontine tegmental nucleus (PPTg); type III neurons that project to the periaqueductal gray matter and the thalamus; and type IV neurons that target the deep mesencephalic nucleus (DpMe) and the SC. The axons of the SNl showed the same branching patterns as SNr axons of types I, II, and IV. The coronal reconstructions demonstrated that SNr neurons innervate the thalamus, the SC, and the DpMe bilaterally. At the thalamic level, SNr and SNl axons targeted preferentially the ventral medial, ventral lateral, paracentral, parafascicular, and mediodorsal nuclei. Axons reaching the SC arborized selectively within the deep layers of this structure. Our results reveal that the SNr and SNl harbor several subtypes of projection neurons endowed with a highly patterned set of axon collaterals. This organization allows single neurons of these output structures of the basal ganglia to exert a multifaceted influence on a wide variety of diencephalic and midbrain structures. (c) 2005 Wiley-Liss, Inc.

  15. Un « gouvernement des journalistes par le Pouvoir politique » par défaut ?

    Directory of Open Access Journals (Sweden)

    Matthieu Lardeau

    2013-12-01

    Full Text Available Cet article présente les interactions de deux mouvements concomitants apparusprincipalement dans les décennies 1950 à 1970 dans le champ de la presse française : d’un côté les initiatives – consécutives à la démarche pionnière, en 1951, de création de la première Société des journalistes (SDJ au sein du Monde – menées par les journalistes de rédactions de quotidiens pour créer des SDJ dont la destination peut aller jusqu’à gouverner les journaux; de l’autre côté, les « réponses » apportées par les Pouvoirs politique et public pour contenir ces initiatives visant à étendre le pouvoir des journalistes dans la gestion et la gouvernance de leurs journaux. Cette étude exploratoire repose principalement sur l’analyse de deux types de littérature, souvent déconsidérés ou négligés par le champ académique, en dépit de leur grande richesse : (1 la littérature professionnelle, ayant pour principaux auteurs les journalistes et managers de presse (Périer Daville, Boegner, Pigasse, etc., florissante depuis 1944 et singulièrement durant les décennies 1960 et 1970 ; (2 la littérature grise constituée notamment par des rapports publics rédigés par des institutions comme les services du Premier ministre (commissions Lindon de 1970 et Serisé de 1972, le Conseil économique et social, etc. Nos principaux résultats montrent que les propositions ou actions menées par les journalistes (1 restent le plus souvent inexploitées in concreto par les journalistes eux-mêmes; (2 entrent le plus souvent en opposition avec les politiques de nouveaux actionnaires ou directions de journaux et avec les projets des autorités politiques et publiques qui cherchent à encadrer l’autonomie de la profession journalistique pour mieux gouverner celle-ci ; (3 combien in fine les représentants des différents acteurs impliqués s’accordent pour contenir l’émergence d’un « gouvernement des journalistes » par les

  16. Cancro em mogno africano no estado do Pará

    Directory of Open Access Journals (Sweden)

    Célia Regina Tremacoldi

    2013-06-01

    Full Text Available Sintomas de cancro foram observados em plantios de mogno africano, no município de Dom Eliseu, Pará. Os fungos associados aos tecidos sintomáticos foram identificados como Lasiodiplodia theobromae e Fusarium subglutinans. Culturas puras desses fungos foram testadas quanto à patogenicidade em mudas de mogno africano sadias. Apenas L. theobromae produziu cancro, por meio de inoculação por ferimento e alta umidade. A confirmação de L. theobromae como agente causal do cancro ocorreu após o reisolamento do fungo a partir das plantas inoculadas em casa de vegetação, concluindo a primeira verificação do postulado de Koch para esse patossistema.

  17. Hemangioma capilar de la parótida. Abordaje transoral

    Directory of Open Access Journals (Sweden)

    Luis Domingo Sarra

    2014-10-01

    Presentamos un caso en una paciente adulta que consultó por una masa en la región parotídea y parálisis facial periférica con el mayor componente tumoral que se manifestaba en la cavidad oral. La ecografía mostró una masa sólida. La punción aspiración con aguja fina fue negativa con material hemático en 2 oportunidades. No tuvimos sospecha de la presencia de un tumor de origen vascular, por lo que no fue solicitada una RMN. El caso fue resuelto a través de un abordaje quirúrgico poco utilizado, tras obtener una biopsia por congelación negativa.

  18. Parálisis cerebral. Tratamiento ortopodológico

    OpenAIRE

    Querol Martínez, Esther; Crespo Martínez, Artur; Concustell Gonfaus, Josep; Sacristán Valero, Sergi; Concustell Fargas, Olga; Carrera Casanova, Ana

    2005-01-01

    Después de varios años de experiencia en la aplicación de las férulas estabilizadoras del sistema aquileocalcáneo plantar FESAP) en pacientes con parálisis cerebral, creemos que deberían ser el tratamiento ortopodológico de elección del pie equino en niños con miopatías y lesiones neurológlcas de la unidad motora, del sistema piramidal o extrapiramidal, tanto por su perfecta adaptación a la morfología de la extremidad inferior como por sus caracteristicas funcionales y sus acciones fisio1ógic...

  19. Myopathy in horses with pituitary pars intermedia dysfunction (Cushing's disease).

    Science.gov (United States)

    Aleman, M; Watson, J L; Williams, D C; LeCouteur, R A; Nieto, J E; Shelton, G D

    2006-11-01

    Fifteen horses with pituitary pars intermedia dysfunction were studied. The horses were of various breeds and between 15 and 28 years of age. Control horses matched for breed and age were studied for comparison. Evaluations included complete blood cell count and serum biochemical analysis, electromyography, and gluteus medius muscle biopsies for histochemical, morphometric, and ultrastructural analysis. No differences were found between groups of horses on routine laboratory analysis or electromyography. We demonstrated that muscle wasting in diseased horses was the result of atrophy of types 2A and 2B muscle fibers and loss of type 2B myofibers. Mild non-specific non-inflammatory myopathic alterations such as myofiber size variation, internal nuclei, perimysial, endomysial and sarcoplasmic fat accumulation were observed. At the ultrastructural level, subsarcolemmal mitochondrial accumulation and increased lipid droplets were evident. Similar to other species, this study confirmed atrophy of type 2 fibers as the cause of muscle mass loss in horses with Cushing's disease.

  20. IMPROVEMENT OF PRODUCTION PLANNING IN COMPANY PARS KOMPONENTY

    Directory of Open Access Journals (Sweden)

    René Klega

    2014-03-01

    Full Text Available The article analyzes the current status of production planning in company Pars Komponenty s.r.o., proposes a new method of planning based on application of the principle of MRP. It is a discrete type of production with high complexity of BOM and MTO (Make-to-Order and ETO (Engineering-to-Order from the point of decoupling point. The original planning system plans according to production capacity backward without collisions, but for a given type of production does not work in practice. Planning system was analyzed and the main problems were identified, which were high work in progress and material stocks. This article target is to propose a new planining system based on the inclusion of time reserves of purchased material items. New planning system was tested in practise with benefit in reducing both the material inventory and work in progress.

  1. Paternal age related schizophrenia (PARS): Latent subgroups detected by k-means clustering analysis.

    Science.gov (United States)

    Lee, Hyejoo; Malaspina, Dolores; Ahn, Hongshik; Perrin, Mary; Opler, Mark G; Kleinhaus, Karine; Harlap, Susan; Goetz, Raymond; Antonius, Daniel

    2011-05-01

    Paternal age related schizophrenia (PARS) has been proposed as a subgroup of schizophrenia with distinct etiology, pathophysiology and symptoms. This study uses a k-means clustering analysis approach to generate hypotheses about differences between PARS and other cases of schizophrenia. We studied PARS (operationally defined as not having any family history of schizophrenia among first and second-degree relatives and fathers' age at birth ≥ 35 years) in a series of schizophrenia cases recruited from a research unit. Data were available on demographic variables, symptoms (Positive and Negative Syndrome Scale; PANSS), cognitive tests (Wechsler Adult Intelligence Scale-Revised; WAIS-R) and olfaction (University of Pennsylvania Smell Identification Test; UPSIT). We conducted a series of k-means clustering analyses to identify clusters of cases containing high concentrations of PARS. Two analyses generated clusters with high concentrations of PARS cases. The first analysis (N=136; PARS=34) revealed a cluster containing 83% PARS cases, in which the patients showed a significant discrepancy between verbal and performance intelligence. The mean paternal and maternal ages were 41 and 33, respectively. The second analysis (N=123; PARS=30) revealed a cluster containing 71% PARS cases, of which 93% were females; the mean age of onset of psychosis, at 17.2, was significantly early. These results strengthen the evidence that PARS cases differ from other patients with schizophrenia. Hypothesis-generating findings suggest that features of PARS may include a discrepancy between verbal and performance intelligence, and in females, an early age of onset. These findings provide a rationale for separating these phenotypes from others in future clinical, genetic and pathophysiologic studies of schizophrenia and in considering responses to treatment. Copyright © 2011 Elsevier B.V. All rights reserved.

  2. Determination of tritium by counting; Dosage du tritium par comptage

    Energy Technology Data Exchange (ETDEWEB)

    Schott, R.; Froment, G.; Pinson, J.; Genty, C. [Commissariat a l' Energie Atomique, Bruyeres-le-Chatel (France). Centre d' Etudes

    1968-07-01

    Ionisation chamber assay of tritium in any gaseous mixture is a simple, fast and accurate method. We used the method of relative determination by comparison to a standard rather than the method of absolute assay in which case the constants are known with too little accuracy. The efficiency of the chamber was studied in connection to the pressure inside the chamber and its total volume. The calibration is linear in the range we are taking into account (1 to 80 millicuries). The reproducibility of the method is good: 13 runs gave a coefficient of variation of 1.6 per cent. The relative accuracy was found equal to {+-} 1.3 per cent. To end the paper, we describe in detail the apparatus and the ways of proceedings. (authors) [French] Le comptage du tritium par chambre d'ionisation est une methode simple, rapide et precise pour determiner la teneur en tritium d'un melange gazeux quelconque. Nous avons prefere utiliser la methode de determination relative par rapport a un etalon car, dans le cas d'une determination absolue, les constantes sont connues avec une trop grande incertitude. L'efficacite de la chambre a ete etudiee en fonction de la variation de la pression d'argon a l'interieur de la chambre et du volume total, de cette derniere. L'etalonnage s'est revele lineaire dans le domaine de mesures qui nous interessaient (1 a 80 millicuries). La reproductibillte de la methode est tres bonne, le coefficient de variation pour une serie de 13 essais etant de 1,6 pour cent, quant a la precision relative, elle a ete evaluee a {+-} 1,3 pour cent. Pour terminer, nous donnons une description detaillee de l'appareillage utilise et du mode operatoire suivi. (auteurs)

  3. Clinical outcomes of pars plicata anterior vitrectomy: 2-year results

    Directory of Open Access Journals (Sweden)

    Priya Narang

    2015-01-01

    Full Text Available Purpose: To demonstrate the safety and outcome of a surgical approach that uses pars plicata site for anterior vitrectomy during phacoemulsification procedure complicated by posterior capsule rupture and residual cortical matter. Design: Single center, retrospective, interventional, noncomparative study. Materials and Methods: Medical records of a consecutive series of 35 eyes of 35 patients who underwent pars plicata anterior vitrectomy (PPAV were reviewed. The main outcome measures were corrected and uncorrected distance visual acuity (CDVA, UDVA, early and late postoperative complications and intraocular pressure (IOP. Ultrasound biomicroscopic (UBM evaluation of sclerotomy site and spectral domain optical coherence tomography analysis for central macular thickness (CMT was performed. The final visual outcome at 2 years was evaluated. Results: At 2 years follow-up, the mean postoperative UDVA (logarithm of the minimum angle of resolution [logMAR] and CDVA (logMAR was 0.49 ± 0.26 and 0.19 ± 0.14, respectively. There was no significant change in the IOP (P = 0.061 and the mean CMT at 2 years was 192.5 ± 5.54 mm. The postoperative UBM image of the sclerotomy site at 8 weeks demonstrated a clear wound without any vitreous adhesion or incarceration. Intraoperative hyphema was seen in 1 (2.8% case and postoperative uveitis was seen in 2 (5.7% cases, which resolved with medications. No case of an iatrogenic retinal break or retinal detachment was reported. Conclusions: PPAV enables a closed chamber approach, allows thorough cleanup of vitreous in the pupillary plane and anterior chamber and affords better access to the subincisional and retropupillary cortical remnant with a significant visual outcome and an acceptable complication rate.

  4. [The course of zonular fibers in the area of pars plicata corporis cilaris pars plana, ora serrata and retina. Eectron microsocpic study].

    Science.gov (United States)

    Roll, P; Reich, M E; Hofmann, H

    1975-01-01

    The course of zonular fibers in the area of pars plicata corporis ciliaris could be shown down to the pigmented epithelial layer and its basement membrane. S ingle fibrils enter in a connection with the plasma membrane in allinvestigated parts. Fibrils could be observed in the cytoplasm of the ora serrata. For the other areas (pars plicata corporis ciliaris, parsplana) this can be suggested too.

  5. Cartographie et ordinateur au lycée

    Directory of Open Access Journals (Sweden)

    Thierry HATT

    1987-06-01

    Full Text Available Travail de cartographie automatique et d'analyse de données au lycée, destiné à promouvoir une initiation à la recherche scientifique et à la maîtrise de l'image. Présentation des objectifs, du logiciel SESAM, des productions réalisées.

  6. Effect of pre-drying and par-frying conditions on the crispness of French fries

    NARCIS (Netherlands)

    Loon, W.A.M.; Visser, J.E.; Linssen, J.P.H.; Somsen, D.J.; Klok, H.J.; Voragen, A.G.J.

    2007-01-01

    An experimental design was used to study the effect of pre-drying (to 10, 15 and 20% weight loss) and par-frying conditions (160, 170 and 180 °C) on the crispness of French fries. Par-frying time was adjusted with a software program to obtain equal moisture content and internal texture for all

  7. Human bronchial epithelial cells express PAR-2 with different sensitivity to thermolysin.

    Science.gov (United States)

    Ubl, Joachim J; Grishina, Zoryana V; Sukhomlin, Tatiana K; Welte, Tobias; Sedehizade, Fariba; Reiser, Georg

    2002-06-01

    Protease-activated receptor-2 (PAR-2) plays a role in inflammatory reactions in airway physiology. Proteases cleaving the extracellular NH(2) terminus of receptors activate or inactivate PAR, thus possessing a therapeutic potential. Using RT-PCR and immunocytochemistry, we show PAR-2 in human airway epithelial cell lines human bronchial epithelial (HBE) and A549. Functional expression of PAR-2 was confirmed by Ca(2+) imaging studies using the receptor agonist protease trypsin. The effect was abolished by soybean trypsin inhibitor and mimicked by the specific PAR-2 peptide agonist SLIGKV. Amplitude and duration of PAR-2-elicited Ca(2+) response in HBE and A549 cells depend on concentration and time of agonist superfusion. The response is partially pertussis toxin (PTX) insensitive, abolished by the phospholipase C inhibitor U-73122, and diminished by the inositol 1,4,5-trisphosphate receptor antagonist 2-aminoethoxydiphenyl borate. Cathepsin G altered neither the resting Ca(2+) level nor PAR-2-elicited Ca(2+) response. Thermolysin, a prototypic bacterial metalloprotease, induced a dose-dependent Ca(2+) response in HBE, but not A549, cells. In both cell lines, thermolysin abolished the response to a subsequent trypsin challenge but not to SLIGKV. Thus different epithelial cell types express different PAR-2 with identical responses to physiological stimuli (trypsin, SLIGKV) but different sensitivity to modifying proteases, such as thermolysin.

  8. Urokinase-type plasminogen activator receptor (uPAR) as a promising new imaging target

    DEFF Research Database (Denmark)

    Persson, Morten; Kjaer, Andreas

    2013-01-01

    modalities such as optical imaging, magnetic resonance imaging, single photon emission computer tomography (SPECT) and positron emission topography (PET). In this review, we will discuss recent advances in the development of uPAR-targeted imaging ligands according to imaging modality. In addition, we...... will discuss the potential future clinical application for uPAR imaging as a new imaging biomarker....

  9. PET imaging of urokinase-type plasminogen activator receptor (uPAR) in prostate cancer

    DEFF Research Database (Denmark)

    Skovgaard, Dorthe; Persson, Morten; Kjaer, Andreas

    2016-01-01

    , which can provide the required quantitative information on the uPAR expression profile, without the need for invasive procedures and the risk of missing the target due to tumor heterogeneity. These observations support non-invasive PET imaging of uPAR in PC as a clinically relevant diagnostic...

  10. Réduction du risque d'infection par le VIH au Botswana - essais ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    sida qui ont entraîné une diminution des taux d'infection par le VIH, ... Le projet sera piloté par le CIET Trust et la National AIDS Coordinating Agency, qui travailleront en étroite collaboration avec le ministère de la Santé et le ministère des ...

  11. Effect of Par Frying on Composition and Texture of Breaded and Battered Catfish

    Science.gov (United States)

    Catfish is often consumed as a breaded and battered fried product; however, baking is considered a healthier alternative to frying. One method of improving the texture properties of baked products is to par fried prior to baking. The objective of this study was to examine the effect of par frying ...

  12. Solar PAR and UVR modify the community composition and photosynthetic activity of sea ice algae.

    Science.gov (United States)

    Enberg, Sara; Piiparinen, Jonna; Majaneva, Markus; Vähätalo, Anssi V; Autio, Riitta; Rintala, Janne-Markus

    2015-10-01

    The effects of increased photosynthetically active radiation (PAR) and ultraviolet radiation (UVR) on species diversity, biomass and photosynthetic activity were studied in fast ice algal communities. The experimental set-up consisted of nine 1.44 m(2) squares with three treatments: untreated with natural snow cover (UNT), snow-free (PAR + UVR) and snow-free ice covered with a UV screen (PAR). The total algal biomass, dominated by diatoms and dinoflagellates, increased in all treatments during the experiment. However, the smaller biomass growth in the top 10-cm layer of the PAR + UVR treatment compared with the PAR treatment indicated the negative effect of UVR. Scrippsiella complex (mainly Scrippsiella hangoei, Biecheleria baltica and Gymnodinium corollarium) showed UV sensitivity in the top 5-cm layer, whereas Heterocapsa arctica ssp. frigida and green algae showed sensitivity to both PAR and UVR. The photosynthetic activity was highest in the top 5-cm layer of the PAR treatment, where the biomass of the pennate diatom Nitzschia frigida increased, indicating the UV sensitivity of this species. This study shows that UVR is one of the controlling factors of algal communities in Baltic Sea ice, and that increased availability of PAR together with UVR exclusion can cause changes in algal biomass, photosynthetic activity and community composition. © FEMS 2015. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  13. Spectral variations of UV-A and PAR solar radiation in estuarine waters of Goa

    Digital Repository Service at National Institute of Oceanography (India)

    Talaulikar, M.; Suresh, T.; Silveira, N.; Desa, E.; Matondkar, S.G.P.; Lotlikar, A.

    radiation (400 to 700 nm), PAR and ultraviolet radiation in the range 350-400 nm (UV-A) are presented here. The mean PAR values at the surface were 327 W/m sup(2) and reduced to 84 W/m sup(2) at first optical depth, Z sub(90) (m) in water. The first optical...

  14. Participatory Action Research (PAR) cum Action Research (AR) in Teacher Professional Development: A Literature Review

    Science.gov (United States)

    Morales, Marie Paz E.

    2016-01-01

    This paper reviews Participatory Action Research as an approach to teacher professional development. It maps the origins of Participatory Action Research (PAR) and discusses the benefits and challenges that have been identified by other researchers in utilizing PAR approaches in conducting research. It draws ideas of combining the features of…

  15. A Bipolar Spindle of Antiparallel ParM Filaments Drives Bacterial Plasmid Segregation

    DEFF Research Database (Denmark)

    Gayathri, P; Fujii, T; Møller-Jensen, Jakob

    2012-01-01

    To ensure their stable inheritance by daughter cells during cell division, bacterial low copy-number plasmids make simple DNA segregating machines that use an elongating protein filament between sister plasmids. In the ParMRC system of Escherichia coli R1 plasmid, ParM, an actin-like protein, forms...

  16. Narrative Identities and the Plebiscite in Pará: An Analysis of the Front Pages for O Liberal and Diário do Pará

    Directory of Open Access Journals (Sweden)

    Alda Cristina Silva da Costa

    2017-05-01

    Full Text Available On December 11, 2011, a plebiscite was held in Pará proposing to create two separatist states, Carajás and Tapajós, out of the state of Pará. The public voted against both projects. This article analyzes the narrative identities found on the front pages of O Liberal and Diário do Pará newspapers about the plebiscite in Pará. Depth Hermeneutics (DH, as proposed by Thompson (2011, was used as the methodological reference. DH emphasizes the object of analysis as a meaningful symbolic construction requiring interpretation. Narrative analysis, as proposed by Motta (2007, was the main research technique used to highlight the movement of construction of journalistic (discursive characters. The narrative identities built by the two newspapers showed that both were against the creation of the new states, but for very different reasons. The flag of Pará was the main object used to induce the idea of unity. Em 11 de dezembro de 2011, o plebiscito no Pará propôs a criação dos estados de Carajás e de Tapajós a partir da divisão do estado do Pará. O resultado da consulta pública foi negativo aos dois projetos. O artigo analisa as identidades narrativas constituídas pelas primeiras páginas dos jornais O Liberal e Diário do Pará sobre o plebiscito no Pará. Utilizou-se como referencial metodológico a Hermenêutica em Profundidade (HP, proposta por Thompson (2011. A HP evidencia o fato de que o objeto de análise é uma construção simbólica significativa, que exige uma interpretação. Como principal técnica de pesquisa, a análise narrativa, proposta por Motta (2007, com ênfase no movimento de construção de personagens jornalísticas (discursivas. As identidades narrativas construídas pelos dois jornais indicaram que ambos eram contrários à criação dos novos estados, porém por motivos divergentes. A bandeira do Pará foi o principal elemento utilizado para evocar a ideia de unidade. En 11 de diciembre de 2011, el plebiscito en

  17. Vogelgriep H5NI in Europa: vooralsnog gering gezondheidsrisico voor Nederland

    NARCIS (Netherlands)

    Timen, A.; van Vliet, J. A.; Koopmans, M. P. G.; van Steenbergen, J. E.; Coutinho, R. A.

    2005-01-01

    Since 2004, outbreaks of fowl plague caused by a highly pathogenic avian influenza virus of the subtype A/H5NI have been reported from various countries in Southeast Asia. To date, 118 cases with 61 deaths have been documented in humans, due to close contact with infected poultry or raw poultry

  18. Effect of simvastatin and ezetimibe on suPAR levels and outcomes

    DEFF Research Database (Denmark)

    Hodges, Gethin W; Bang, Casper N; Forman, Julie L

    2018-01-01

    -lowering therapy also lowers suPAR levels is unknown. METHODS: We investigated whether treatment with Simvastatin 40 mg and Ezetimibe 10 mg lowered plasma suPAR levels in 1838 patients with mild-moderate, asymptomatic aortic stenosis, included in the Simvastatin and Ezetimibe in Aortic Stenosis (SEAS) study, using...... and Ezetimibe treatment impeded the progression of the time-related increase in plasma suPAR levels. Year-1 suPAR was associated with all-cause mortality, MCE, and AVE irrespective of baseline levels (SEAS study: NCT00092677)....... cardiovascular events (MCE) composed of ischemic cardiovascular events (ICE) and aortic valve related events (AVE). RESULTS: After 4.3 years of follow-up, suPAR levels had increased by 9.2% (95% confidence interval [CI]: 7.0%-11.5%) in the placebo group, but only by 4.1% (1.9%-6.2%) in the group with lipid...

  19. par genes in Mycobacterium bovis and Mycobacterium smegmatis are arranged in an operon transcribed from "SigGC" promoters

    Directory of Open Access Journals (Sweden)

    Casart Yveth

    2008-03-01

    Full Text Available Abstract Background The ParA/Soj and ParB/Spo0J proteins, and the cis-acting parS site, participate actively in chromosome segregation and cell cycle progression. Genes homologous to parA and parB, and two putative parS copies, have been identified in the Mycobacterium bovis BCG and Mycobacterium smegmatis chromosomes. As in Mycobacterium tuberculosis, the parA and parB genes in these two non-pathogenic mycobacteria are located near the chromosomal origin of replication. The present work focused on the determination of the transcriptional organisation of the ~6 Kb orf60K-parB region of M. bovis BCG and M. smegmatis by primer extension, transcriptional fusions to the green fluorescence protein (GFP and quantitative RT-PCR. Results The parAB genes were arranged in an operon. However, we also found promoters upstream of each one of these genes. Seven putative promoter sequences were identified in the orf60K-parB region of M. bovis BCG, whilst four were identified in the homologous region of M. smegmatis, one upstream of each open reading frame (ORF. Real-time PCR assays showed that in M. smegmatis, mRNA-parA and mRNA-parB levels decreased between the exponential and stationary phases. In M. bovis BCG, mRNA-parA levels also decreased between the exponential and stationary phases. However, parB expression was higher than parA expression and remained almost unchanged along the growth curve. Conclusion The majority of the proposed promoter regions had features characteristic of Mycobacterium promoters previously denoted as Group D. The -10 hexamer of a strong E. coli σ70-like promoter, located upstream of gidB of M. bovis BCG, overlapped with a putative parS sequence, suggesting that the transcription from this promoter might be regulated by the binding of ParB to parS.

  20. Contribution à l'optimisation du carottage par modélisation de l'initialisation du discage Contribution to the Optimizing of Core Drilling by Modeling the Initiation of Discing

    Directory of Open Access Journals (Sweden)

    Venet V.

    2006-11-01

    Full Text Available L'étude du discage des carottes pétrolières peut être utilisée, soit : - quand il survient, comme un indicateur des contraintes in situ; - comme un moyen d'optimiser le carottage en vue de l'obtention de carottes intactes pour les essais en laboratoire. Nous n'aborderons dans cet article que le dernier aspect du problème. Dans un premier temps, nous dégagerons, à partir d'une étude bibliographique, les principaux paramètres qui influent sur le discage. Le logiciel DISCAGELF (éléments finis en symétrie de révolution sera ensuite décrit succinctement. Il inclut un mailleur automatique et une possibilité d'effectuer une loupe sur la zone à haute probabilité de rupture pour assurer son accessibilité et son implantation éventuelle sur des micro-ordinateurs (type PC. Une validation de ce logiciel à partir d'essais réalisés sur le Triaxial vrai de Lille et sur la cellule à disquer de l'Institut National pour l'Environnement et les Risques (INERIS (avec ou sans simulation de pression de boue a ensuite été effectuée. Dans la quatrième partie de cet article, nous présenterons les résultats essentiels, provenant de plus de 200 simulations numériques, relatifs à l'influence des paramètres : caractéristiques géomécaniques du matériau, densité de boue, poids sur l'outil, type et géométrie de l'outil de carottage, sur les contraintes d'amorce de la rupture. Nous avons ainsi mis en évidence l'existence : - d'un domaine de sécurité vis-à-vis de l'amorce de la rupture ; - de relations linéaires entre les contraintes radiales d'amorce de la rupture d'une part, et les caractéristiques géomécaniques du matériau et la densité de la boue d'autre part ; - de quatre positions préférentielles du point d'amorce de la rupture pour lesquels le mécanisme engendrant la rupture est différent ; - de l'influence du type et de la géométrie du carottier sur l'amorce de la rupture et sur la courbure des disques potentiels

  1. Facteurs de risque de mortalité par tuberculose pulmonaire

    Science.gov (United States)

    Janah, Hicham; Souhi, Hicham; Kouismi, Hatim; Mark, Karima; Zahraoui, Rachida; Benamor, Jouda; Soualhi, Mona; Bourkadi, Jamal Eddine

    2014-01-01

    La tuberculose est une maladie infectieuse transmissible provoquée par myco-bacterium tuberculosis (bacille de Koch ou BK). Elle représente, selon les estimations del'Organisation Mondiale de la Santé (OMS), l'une des pathologies infectieuses causant le plus de décès au niveau mondial avec plus de 1 million de décès par an. Pour déterminer les facteurs de risque de mortalité au cours de la tuberculose pulmonaire à microscopie positive nous avons mené une étude rétrospective portant sur tous les cas de tuberculose pulmonaire à microscopie positive et qui étaient décédés au cours de leur hospitalisation. Cette étude a colligé 1803 cas de tuberculose sur une période de 2 ans et demi dont 46 sont décédés. La prévalence de décès est de 2,55%. La population se répartit en 32 hommes et 14 femmes. L’âge moyen était de 53ans ± 17 ans. Le tabagisme était retrouvé chez la moitié des cas. Une comorbidité était retrouvée dans 43%, avec 17% de diabète. Le délai de diagnostic avait une médiane de 60 jours avec percentile (30j; 105j). La symptomatologie clinique était dominée par la toux, la dyspnée et les expectorations soit respectivement: 97,8%, 69,6% et 67,4% des cas. Sur le plan radiologique les lésions étaient diffuses et bilatérales dans 76,1% des cas. Tous les patients étaient mis sous SRHZ. 11% avaient présenté une toxicité aux antibacillaires (de type hépatiques dans 3 cas et neurologiques dans 2 cas). Le délai médian de décès était de 8,5 jours (5j; 17j). Les causes de décès retrouvées étaient: Une hépatite fulminante (3 cas), une décompensation acido-cétosique (3 cas), un SDRA (2 cas), des hémoptysies foudroyantes (2 cas), et respectivement un cas secondaire à une décompensation de BPCO, une décompensation cardiaque, une hypoglycémie et un tableau d'anasarque. Cette étude suggère que le terrain, le retard diagnostique et les effets secondaires du traitement sont les principaux facteurs de risque de

  2. Urine suPAR levels compared with plasma suPAR levels as predictors of post-consultation mortality risk among individuals assumed to be TB-negative: a prospective cohort study

    DEFF Research Database (Denmark)

    Rabna, Paulo; Andersen, Andreas; Wejse, Christian

    2010-01-01

    -suPAR was measured using a commercial ELISA (suPARnostic®). We found that U-suPAR carried significant prognostic information on mortality for HIV-infected subjects with an area under the ROC curve of 0.75. For HIV-negative individuals, little or no prognostic effect was observed. However, in both HIV positives...... and negatives, the predictive effect of U-suPAR was found to be inferior to that of P-suPAR....

  3. La limitation de l’ontologie par la logique

    Directory of Open Access Journals (Sweden)

    John J. Drummond

    2009-02-01

    Full Text Available Cet article maintient que l’intérêt de Husserl pour le développement d’une logique pure en tant que théorie de la science limite sa conception de l’ontologie. L’ontologie formelle est, pour Husserl, une théorie formelle des objets de connaissance, dont les catégories fondamentales sont celles de substance, propriété et relation. En outre, les ontologies régionales évoluent au sein des limites catégorielles définies par l’ontologie formelle. Mais une telle ontologie laisse de côté les activités et les processus de tout genre, parmi lesquels le plus important est celui de l’ « avoir à l’esprit ». La phénoménologie transcendantale, en revanche, s’occupe de l’être-conscient-du-monde, un être-conscient qui est cependant inséparable de l’être-dans-le-monde. Cette phénoménologie se situe sur le même terrain ontologique que l’ontologie fondamentale de Heidegger. Mais alors, bien que la notion husserlienne d’ontologie soit limitée par le rôle dominant attribué à la logique en tant que théorie de la science et à la connaissance vraie qui lui est propre, il y a plus d’ontologie chez Husserl que dans son « ontologie ».This paper argues that Husserl’s concern with the development of pure logic as a theory of science limits his conception of ontology. Formal ontology is, for Husserl, a formal theory of the objects of cognition, and its fundamental categories are substantiality, property, and relation. Moreover, regional ontologies work within the categorial boundaries defined by formal ontology. Lost from view in this ontology are activities and processes of various kinds, of which “minding” is the most significant. Husserl’s transcendental phenomenology is an account of being-conscious-of-the-world, a being-conscious, however, that is inseparable from being-in-a-world.  This phenomenology is aimed at the same ontological terrain as Heidegger’s fundamental ontology. Hence, while

  4. Evaluation de la qualite osseuse par les ondes guidees ultrasonores =

    Science.gov (United States)

    Abid, Alexandre

    La caracterisation des proprietes mecaniques de l'os cortical est un domaine d'interet pour la recherche orthopedique. En effet, cette caracterisation peut apporter des informations primordiales pour determiner le risque de fracture, la presence de microfractures ou encore depister l'osteoporose. Les deux principales techniques actuelles de caracterisation de ces proprietes sont le Dual-energy X-ray Absorptiometry (DXA) et le Quantitative Computed Tomogaphy (QCT). Ces techniques ne sont pas optimales et presentent certaines limites, ainsi l'efficacite du DXA est questionnee dans le milieu orthopedique tandis que le QCT necessite des niveaux de radiations problematiques pour en faire un outil de depistage. Les ondes guidees ultrasonores sont utilisees depuis de nombreuses annees pour detecter les fissures, la geometrie et les proprietes mecaniques de cylindres, tuyaux et autres structures dans des milieux industriels. De plus, leur utilisation est plus abordable que celle du DXA et n'engendrent pas de radiation ce qui les rendent prometteuses pour detecter les proprietes mecaniques des os. Depuis moins de dix ans, de nombreux laboratoires de recherche tentent de transposer ces techniques au monde medical, en propageant les ondes guidees ultrasonores dans les os. Le travail presente ici a pour but de demontrer le potentiel des ondes guidees ultrasonores pour determiner l'evolution des proprietes mecaniques de l'os cortical. Il commence par une introduction generale sur les ondes guidees ultrasonores et une revue de la litterature des differentes techniques relatives a l'utilisation des ondes guidees ultrasonores sur les os. L'article redige lors de ma maitrise est ensuite presente. L'objectif de cet article est d'exciter et de detecter certains modes des ondes guides presentant une sensibilite a la deterioration des proprietes mecaniques de l'os cortical. Ce travail est realise en modelisant par elements finis la propagation de ces ondes dans deux modeles osseux

  5. Profiling gene expression induced by protease-activated receptor 2 (PAR2 activation in human kidney cells.

    Directory of Open Access Journals (Sweden)

    Jacky Y Suen

    Full Text Available Protease-Activated Receptor-2 (PAR2 has been implicated through genetic knockout mice with cytokine regulation and arthritis development. Many studies have associated PAR2 with inflammatory conditions (arthritis, airways inflammation, IBD and key events in tumor progression (angiogenesis, metastasis, but they have relied heavily on the use of single agonists to identify physiological roles for PAR2. However such probes are now known not to be highly selective for PAR2, and thus precisely what PAR2 does and what mechanisms of downstream regulation are truly affected remain obscure. Effects of PAR2 activation on gene expression in Human Embryonic Kidney cells (HEK293, a commonly studied cell line in PAR2 research, were investigated here by comparing 19,000 human genes for intersecting up- or down-regulation by both trypsin (an endogenous protease that activates PAR2 and a PAR2 activating hexapeptide (2f-LIGRLO-NH(2. Among 2,500 human genes regulated similarly by both agonists, there were clear associations between PAR2 activation and cellular metabolism (1,000 genes, the cell cycle, the MAPK pathway, HDAC and sirtuin enzymes, inflammatory cytokines, and anti-complement function. PAR-2 activation up-regulated four genes more than 5 fold (DUSP6, WWOX, AREG, SERPINB2 and down-regulated another six genes more than 3 fold (TXNIP, RARG, ITGB4, CTSD, MSC and TM4SF15. Both PAR2 and PAR1 activation resulted in up-regulated expression of several genes (CD44, FOSL1, TNFRSF12A, RAB3A, COPEB, CORO1C, THBS1, SDC4 known to be important in cancer. This is the first widespread profiling of specific activation of PAR2 and provides a valuable platform for better understanding key mechanistic roles of PAR2 in human physiology. Results clearly support the development of both antagonists and agonists of human PAR2 as potential disease modifying therapeutic agents.

  6. Envenimation mortelle par morsure de serpent chez une femme enceinte

    Directory of Open Access Journals (Sweden)

    Abdelkarim Shimi

    2011-02-01

    Full Text Available En Afrique, la prise en charge des envenimations vipérines demeure un problème majeur de santé publique avec un taux de mortalité qui reste élevé.La survenue d’une envenimation vipérine au cours de la grossesse est un événement rare, et grave du fait des conséquences maternelles et fatales qui en découlent. Les auteurs rapportent un cas de morsure de serpent au niveau de la face chez une femme enceinte, dont l’évolution a été marquée par l’installation d’un œdème cervico-facial nécessitant une trachéotomie en urgence, et une mort fatale in utero avec troubles de l’hémostase responsable du décès maternel dans un tableau de choc hémorragique.

  7. Lamellar pathology in horses with pituitary pars intermedia dysfunction.

    Science.gov (United States)

    Karikoski, N P; Patterson-Kane, J C; Singer, E R; McFarlane, D; McGowan, C M

    2016-07-01

    Hoof lamellar pathology in horses with pituitary pars intermedia dysfunction (PPID) has not been described previously. To describe the histomorphometry and pathological lesions in hoof lamellar tissue of animals that had PPID with or without concurrent laminitis, with reference to age-matched controls. We hypothesised that lamellar lesions consistent with laminitis would be associated with PPID, even in animals without current or historical laminitis. Prospective case-control study. Mid-dorsal hoof histological sections were obtained post mortem from the forelimbs of 16 PPID-affected animals either with (n = 6) or without laminitis (n = 10) and 10 age- and breed-matched controls. Sections were examined by a blinded veterinary pathologist. The length and width of 10 primary epidermal lamellae were measured using image analysis software. The morphology and pathology of primary and secondary epidermal lamellae were then typed or graded in axial, middle and abaxial regions. Fasting serum insulin, plasma adrenocorticotropin and blood glucose concentration were measured from blood samples taken prior to euthanasia. All animals with PPID and laminitis had fasting hyperinsulinaemia (median 74.1 miu/l, interquartile range 49.9-349.5 miu/l) whereas PPID animals without laminitis had serum insulin concentrations below the upper limit of the reference range (morphological alteration and pathology consistent with laminitis. © 2015 EVJ Ltd.

  8. Monitoreo de parásitos en efluentes domiciliarios

    Directory of Open Access Journals (Sweden)

    Semenas Liliana

    1999-01-01

    Full Text Available OBJETIVO: Evaluar la presencia de parásitos en efluentes semisólidos y líquidos en distintas localidades de la Patagonia argentina considerando que ésta es una de las restricciones para su uso. MÉTODOS: Las muestras tomadas en 4 Plantas de Tratamiento de Efluentes Domiciliarios se analizaron siguiendo las normativas de Environmental Protection Agency, Organización Mundial de la Salud, Standard Methods for Examination of Water and Wastewater y de algunas clasificaciones. RESULTADOS: Solamente 2 de las 6 muestras de semisólidos analizadas tenían huevos de Ascaris lumbricoides no viables. De las 10 muestras líquidas, solamente 2 no tenían huevos mientras las restantes tenían patógenos de las categorías I (Giardia sp., Hymenolepis diminuta y Enterobius vermicularis y III (Ascaris lumbricoides, Ancylostoma duodenale y Trichuris trichiura. CONCLUSIONES: Todas las muestras de semisólidos analizadas fueron aptas para su uso como fertilizantes porque no se registró en ninguna de ellas la presencia de huevos viables de Ascaris lumbricoides y solamente 6 de las muestras líquidas fueron aptas para riego por carecer de huevos o por ser su concentración igual o inferior a 1 huevo por litro.

  9. Characterization of ParTI Phoswiches Using Charged Pion Beams

    Science.gov (United States)

    Churchman, Emily; Zarrella, Andrew; Youngs, Michael; Yennello, Sherry

    2017-09-01

    The Partial Truncated Icosahedron (ParTI) detector array consists of 15 phoswiches. Each phoswich is made of two scintillating components - a thallium-doped cesium iodide (CsI(Tl)) crystal and an EJ-212 scintillating plastic - coupled to a photomultiplier tube. Both materials have different scintillation times and are sensitive to both charged and neutral particles. The type of particle and amount of energy deposited determine the shape of the scintillation pulse as a function of time. By integrating the fast and slow signals of the scintillation pulses, a ``Fast vs. Slow Integration'' plot can be created that produces particle identification lines based on the energy deposited in the scintillating materials. Four of these phoswiches were taken to the Paul Scherrer Institute (PSI) in Switzerland where π + , π-, and proton beams were scattered onto the phoswiches to demonstrate their particle identification (PID) capabilities. Using digitizers to record the detector response waveforms, pions can also be identified by the characteristic decay pulse of the muon daughters.

  10. Hunger amidst plenty along the coast of Pará

    Directory of Open Access Journals (Sweden)

    Ivete Nascimento

    2006-08-01

    Full Text Available In this work one analyzes some referring questions to the new significações of the temporality constructed socially enters the artisan fishing of the coast, in the city of Maracanã, using as boundary-maker the concepts the concepts of abundance and famitura the one that they send themselves to the speech in way of life of the past and the gift. It will see as the typical way of life of the rescued past of the memory of old and the meaning of the abundance in the time of the fishing-farmer, the counterpoint with the concept of famitura of the fishing-exclusive of the gift, where the loss surpasses the scope of the strict survival reaching the proper way of life with the weakness of solidarity. This analysis will be given mecanicamente in the conceptual field of the time measured for the tasks and of the time chronometered for the clock. The intensive field work ocurred on Fortaleza of the Mocooca community incorporating data gotten a long the author's experience in the fish artisan thematic of the Pará coast.

  11. Characterization of a dodecapeptide containing a dominant epitope of Par j 1 and Par o 1, the major allergens of P. judaica and P. officinalis pollen.

    Science.gov (United States)

    Menna, T; Cassese, G; Di Modugno, F; Chersi, A; Buono, C; Ruffilli, A

    1999-10-01

    The pollen of Parietaria, a weed of the Urticaceae family, is a major cause of respiratory allergy in Europe, where the most common species are P. judaica and P. officinalis. Previously, we reported that a beta-galactosidase fusion protein (6a-BG) expressing a 26-bp cDNA fragment (6a cDNA) contained a dominant IgE-binding epitope (6a epitope) of the major allergens Par o 1 and Par j 1. The present study aimed to define the amino-acid sequence containing the 6a epitope. We analyzed the reactivity of anti-Par o 1 antibodies affinity purified from allergic patient sera with: 1) a panel of synthetic peptides deduced from the 6a nucleotide sequence using different reading frames 2) glutathione S-transferase (GST) fusion proteins containing selected peptides. The peptide NSARARADSCRI (p102) specifically bound anti-Par o 1 antibodies affinity purified from allergic patient sera or from rabbit anti-Par o 1 antiserum (ELISA). The related peptide NSARAGTSSCRI (p101) reacted to human but not to rabbit, anti-Par o 1 antibodies. GST fusion proteins containing p101 (GST 3.5) or p102 (GST 3.2) extensively inhibited the binding between Par o 1 and IgE or IgG antibodies from an allergic patient serum pool according to a dose-response curve. Percent inhibition of IgE antibodies binding obtained by absorbing a solution (50 microl) of affinity-purified antibodies with 5 microg of GST 3.2 or with 1.2 mg of GST 3.5 was 69% and 66%, respectively. In conclusion, the results of the present study indicate that the amino-acid sequences NSARARADSCRI (p102) and NSARAGTSSCRI (p101) contain the dominant epitope of Par o 1 and Par j 1 for human IgE and IgG antibodies indicated as 6a epitope. Moreover, the study shows that the epitope is conserved in recombinant molecules containing these peptides, irrespective of the fused polypeptide (beta-galactosidase or GST). The knowledge of the amino-acid sequence of this dominant epitope is important in therapeutic approaches to the development of allergen

  12. Effects of solar PAR and UV radiation on tropical biofouling communities

    KAUST Repository

    Dobretsov, SV

    2010-03-08

    We investigated the effect of solar ultraviolet radiation (UVR) and photosynthetically active radiation (PAR) on the development of tropical micro- and macrofouling communities for 30 d. The experimental design involved 3 treatments: full spectrum (PAR+UVR), PAR only, and minimal light (reduced PAR and UVR). Terminal restriction fragment length polymorphism analysis demonstrated that different light conditions resulted in the formation of highly different microbial communities. The lowest densities of bacteria were found under the full spectrum treatment, while the lowest densities of diatoms were found in the minimal light treatment. Macrofouling communities consisted of 13 species and differed among light treatments. In the presence of UVR, communities had low species diversity, evenness, and richness, while in minimal light and PAR treatments, communities had high species diversity, evenness, and richness. Similarity percentage (SIMPER) analysis revealed that the tubeworm Hydroides elegans, the alga Ulva (Enteromorpha) sp., and the bivalve Perna viridis were the species responsible for most of the dissimilarities in macrofouling communities among treatments. While densities of H. elegans were similar in the PAR and minimal light treatments, this polychaete had higher growth rates under minimal light conditions. We conclude that UVR and PAR directly control the development of shallow micro- and macrofouling communities by inhibiting the recruitment and growth of sensitive species and promoting the growth of resistant species, but also that these forms of solar radiation influence the surface cues available to competent larvae by altering the development of the microbial community.

  13. Blocking PAR2 alleviates bladder pain and hyperactivity via TRPA1 signal

    Directory of Open Access Journals (Sweden)

    Chen Daihui

    2016-01-01

    Full Text Available Bladder disorders associated with interstitial cystitis are frequently characterized by increased contractility and pain. The goals of this study were to examine 1 the effects of blocking proteinase-activated receptor-2 (PAR2 on the exaggerated bladder activity and pain evoked by cystitis and 2 the underlying mechanisms responsible for the role of PAR2 in regulating cystic sensory activity. The protein expression of PAR2 was amplified in rats with cystitis by inducing it with systemic administration of cyclophosphamide (CYP as compared with control rats. Blocking PAR2 by intrathecal infusion of PAR2 antagonist FSLLRY-NH2 attenuated bladder hyperactivity and pain. In addition, blocking PAR2 attenuated the transient receptor potential A1 (TRPA1 signal pathway, whereas inhibition of the TRPA1 decreased bladder hyperactivity and pain. The data revealed specific signaling pathways leading to CYP-induced bladder hyperactivity and pain, including the activation of PAR2 and TRPA1. Inhibition of these pathways alleviates cystic pain. Targeting one or more of these signaling molecules may present new opportunities for treatment and management of overactive bladder and pain often observed in cystitis.

  14. Caractérisation par ellipsométrie spectroscopique de films minces de tellurure de bismuth obtenus par voie électrochimique

    Science.gov (United States)

    Zimmer, A.; Stein, N.; Boulanger, C.; Johann, L.

    2004-12-01

    Des films de tellurure de bismuth (Bi2Te3) d’épaisseur proche de 1 mm ont été développés par voie électrochimique. Leurs indices optiques ont été déterminés par ellipsométrie spectroscopique (SE). Le domaine spectral des indices optiques s’étend de 400 nm à 1300 nm. L’ellipsométrie spectroscopique à angle d’incidence variable (VASE) a été utilisée pour corréler les données SE. Cette partie a été complétée par des analyses par microscopie à force atomique (AFM) qui ont permis de déterminer la rugosité des films. A partir de ces résultats et en associant l’absorption fondamentale des films de Bi2Te3 à une transition indirecte, l’énergie de bande interdite a été évaluée à 0,3 eV. Par ailleurs des mesures associant ellipsométrie spectroscopique à temps réel et électrochimie ont pu être réalisées. Ainsi les premiers instants de croissance ont été observés.

  15. Expression of prostate apoptosis response (Par-4) is associated with progesterone receptor in breast cancer.

    Science.gov (United States)

    Zapata-Benavides, Pablo; Méndez-Vázquez, José L; González-Rocha, Talina R; Zamora-Avila, Diana E; Franco-Molina, Moises A; Garza-Garza, Raúl; Rodriguez-Padilla, Cristina

    2009-10-01

    The prostate apoptosis response (Par-4) gene encodes a proapoptotic protein that selectively induces apoptosis in cancer cells after diverse apoptotic stimuli. Par-4 expression and its association with other biomarkers have not been reported in breast cancer. The purpose of this study was to determine Par-4 expression in breast cancer samples and its association with other biomarkers and clinical factors (T-stage, age, nodal status). Paraffin-embedded section samples of breast cancer were evaluated by immunohistochemical analysis to determine Par-4, estrogen receptor (ER), progesterone receptor (PgR), c-erbB2, Ki67, p53 and bcl-2 expression. The correlation between Par-4 and the other biomarkers and clinical factors was determined by multivariate analysis. Thirty five percent (n=21) of samples were PAR-4 positive and 64.4% (n=38) were negative. The hormonal status was 64% ER positive (n=38), 35% ER-negative (n=21) and 40.7% PgR positive (n=24), 59.3% PgR negative (n=35). The majority (90%) of the samples presented clear cytoplasmic localization and a small portion (10%) was cytoplasmic and nuclear. Univariate analysis indicates that the Par-4 expression has a significant inverse association (p=0.04) only with expression of PgR and not with the other variables analyzed. Normal breast tissue analyzed was negative for Par-4 immunostaining. Our results suggest that, in breast cancer, Par-4 plays a similar tumor suppressor gene role as reported in endometrial carcinoma. 2009. Published by Elsevier Inc.

  16. The urokinase receptor (uPAR facilitates clearance of Borrelia burgdorferi.

    Directory of Open Access Journals (Sweden)

    Joppe W R Hovius

    2009-05-01

    Full Text Available The causative agent of Lyme borreliosis, the spirochete Borrelia burgdorferi, has been shown to induce expression of the urokinase receptor (uPAR; however, the role of uPAR in the immune response against Borrelia has never been investigated. uPAR not only acts as a proteinase receptor, but can also, dependently or independently of ligation to uPA, directly affect leukocyte function. We here demonstrate that uPAR is upregulated on murine and human leukocytes upon exposure to B. burgdorferi both in vitro as well as in vivo. Notably, B. burgdorferi-inoculated C57BL/6 uPAR knock-out mice harbored significantly higher Borrelia numbers compared to WT controls. This was associated with impaired phagocytotic capacity of B. burgdorferi by uPAR knock-out leukocytes in vitro. B. burgdorferi numbers in vivo, and phagocytotic capacity in vitro, were unaltered in uPA, tPA (low fibrinolytic activity and PAI-1 (high fibrinolytic activity knock-out mice compared to WT controls. Strikingly, in uPAR knock-out mice partially backcrossed to a B. burgdorferi susceptible C3H/HeN background, higher B. burgdorferi numbers were associated with more severe carditis and increased local TLR2 and IL-1beta mRNA expression. In conclusion, in B. burgdorferi infection, uPAR is required for phagocytosis and adequate eradication of the spirochete from the heart by a mechanism that is independent of binding of uPAR to uPA or its role in the fibrinolytic system.

  17. MMP-1/PAR-1 signal transduction axis and its prognostic impact in esophageal squamous cell carcinoma

    Directory of Open Access Journals (Sweden)

    Hong-hua Peng

    2012-01-01

    Full Text Available The matrix metalloprotease-1 (MMP-1/protease-activated receptor-1 (PAR-1 signal transduction axis plays an important role in tumorigenesis. To explore the expression and prognostic value of MMP-1 and PAR-1 in esophageal squamous cell carcinoma (ESCC, we evaluated the expression of two proteins in resected specimens from 85 patients with ESCC by immunohistochemistry. Sixty-two (72.9% and 58 (68.2% tumors were MMP-1- and PAR-1-positive, respectively, while no significant staining was observed in normal esophageal squamous epithelium. MMP-1 and PAR-1 overexpression was significantly associated with tumor node metastasis (TNM stage and regional lymph node involvement. Patients with MMP-1- and PAR-1-positive tumors, respectively, had poorer disease-free survival (DFS than those with negative ESCC (P = 0.002 and 0.003, respectively. Univariate analysis showed a significant relationship between TNM stage [hazard ratio (HR = 2.836, 95% confidence interval (CI = 1.866-4.308], regional lymph node involvement (HR = 2.955, 95%CI = 1.713-5.068, MMP-1 expression (HR = 2.669, 95%CI = 1.229-6.127, and PAR-1 expression (HR = 1.762, 95%CI = 1.156-2.883 and DFS. Multivariate analysis including the above four parameters identified TNM stage (HR = 2.035, 95%CI = 1.167-3.681, MMP-1 expression (HR = 2.109, 95%CI = 1.293-3.279, and PAR-1 expression (HR = 1.967, 95%CI = 1.256-2.881 as independent and significant prognostic factors for DFS. Our data suggest for the first time that MMP-1 and PAR-1 were both overexpressed in ESCC and are novel predictors of poor patient prognosis after curative resection. The MMP-1/PAR-1 signal transduction axis might be a new therapeutic target for future therapies tailored against ESCC.

  18. Provenance of the oil in par-fried French fries after finish frying.

    Science.gov (United States)

    Al-Khusaibi, Mohammed; Gordon, Michael H; Lovegrove, Julie A; Niranjan, Keshavan

    2012-01-01

    Frozen par-fried French fries are finish-fried either by using the same type of oil used for par frying, or a different type. The nutritive quality of the final oil contained in the product depends on the relative amounts and the fatty acid (FA) composition of the oils used for par frying and finish frying. With the aim of understanding the provenance of the oil in the final product, par-fried French fries-either purchased ready or prepared in the laboratory-were finish fried in oils different from the ones used for par frying. The moisture content, oil content, and FA compositions of the par-fried and finish-fried products were experimentally determined, and the relative amounts of each of the oils present in the final product were calculated using the FAs as markers and undertaking a mass balance on each component FA. The results demonstrate that 89% to 93% of the total oil in the final product originates from the finish-frying step. The study also shows that a significant proportion of the oil absorbed during par frying is expelled from the product during finish frying. Further, the expulsion of par-frying oil was found to occur in the early stages of the finish-frying step. Experiments involving different combinations of par-frying and finish-frying oils showed that the relative proportions of the 2 oils did not depend on the individual fatty acid profiles. This study concludes that any positive health benefits of using an oil having a favorable FA profile for par frying, can potentially be lost, if the oil used for finish frying has a less favorable composition. This paper estimates the relative amounts of oil in French fries that have been fried in 2 stages-a par-frying step and a finish-frying step-which is commonly practiced in food service establishments as well as homes. The 2 key conclusions are: (1) nearly 90% of the oil content of the final product is the one used for finish frying; that is, a processor may use very good oil for par frying but if the

  19. Influence of P-Reactor operation on the aquatic ecology of Par Pond: a literature review

    International Nuclear Information System (INIS)

    Wilde, E.W.; Tilly, L.J.

    1985-02-01

    Par Pond is a 1012 hectare reservoir that was constructed in 1958 to provide cooling water for Savannah River nuclear reactors. The purpose of this report is to summarize all known studies on the Par Pond system and point out demonstrable or probable effects that can be correlated with reactor operations. Reactor operation effects the Par Pond ecosystem through: (1) pumping, (2) thermal alteration, and (3) the addition of Savannah River makeup water. The influence of each of these factors is discussed. 108 references, 24 figures, 34 tables. (MF)

  20. Profils des enfants infectes par le vih en debut du traitement ...

    African Journals Online (AJOL)

    But : Décrire les profils des enfants infectés par le VIH au début du traitement antirétroviral. Matériels et méthode: Les dossiers des enfants infectés par le VIH dans la région maritime ont été analysés de mai 2008 à février 2010 par le comité thérapeutique. Résultats: Parmi les 96 dossiers analysés, 66,67% venaient du ...

  1. Les dispensées par fantaisie en éducation physique et sportive ...

    African Journals Online (AJOL)

    Cette étude vise à comprendre les raisons avancées par les élèves dispensés par fantaisie des cours d'EPS, pour justifier leur attitude et principalement leur forfait. Une enquête par questionnaire écrit a été menée dans 13 établissements publics de la ville de Porto-Novo au Bénin. Au total, 203 élèves parmi les 771 élèves ...

  2. Thrombin induces rapid PAR1-mediated non-classical FGF1 release

    International Nuclear Information System (INIS)

    Duarte, Maria; Kolev, Vihren; Soldi, Raffaella; Kirov, Alexander; Graziani, Irene; Oliveira, Silvia Marta; Kacer, Doreen; Friesel, Robert; Maciag, Thomas; Prudovsky, Igor

    2006-01-01

    Thrombin induces cell proliferation and migration during vascular injury. We report that thrombin rapidly stimulated expression and release of the pro-angiogenic polypeptide fibroblast growth factor 1 (FGF1). Thrombin failed to induce FGF1 release from protease-activated receptor 1 (PAR1) null fibroblasts, indicating that this effect was dependent on PAR1. Similarly to thrombin, FGF1 expression and release were induced by TRAP, a specific oligopeptide agonist of PAR1. These results identify a novel aspect of the crosstalk between FGF and thrombin signaling pathways which both play important roles in tissue repair and angiogenesis

  3. Structure and ligand interactions of the urokinase receptor (uPAR)

    DEFF Research Database (Denmark)

    Kjaergaard, Magnus; Hansen, Line V.; Jacobsen, Benedikte

    2008-01-01

    The urokinase-type plasminogen activator receptor (uPAR or CD87) is a glycolipid-anchored membrane glycoprotein, which is responsible for focalizing plasminogen activation to the cell surface through its high-affinity binding to the serine protease uPA. This tight interaction (KD less than 1 n...... on disulfide connectivities, and they adopt a characteristic three-finger fold. Interestingly, the gene for uPAR is localized in a cluster of 6 homologous genes encoding proteins with multiple LU-domains. The structural biology of uPAR will be reviewed with special emphasis on its multidomain composition...

  4. Data on the regulation of moesin and merlin by the urokinase receptor (uPAR: Model explaining distal activation of integrins by uPAR

    Directory of Open Access Journals (Sweden)

    Bernard Degryse

    2017-12-01

    Full Text Available The data presented herein are connected to our research article (doi: 10.1016/j.biocel.2017.04.012 [1], in which we investigated the functional connections between the urokinase receptor (uPAR, and the ezrin/radixin/moesin (ERM proteins, moesin and merlin [1]. Firstly, a model of action is proposed that enlightens how uPAR regulates distal integrins. In addition, data show the effects of expressing wild-type moesin or permanently active T558D mutant of moesin on angiogenesis and morphology of human aortic endothelial cells (HAEC. Additional data compare the effects of urokinase (uPA, the main ligand of uPAR on the same cells. Lastly, we provide technical data demonstrating the effects of specific siRNA for moesin and merlin on moesin and merlin expression, respectively. Keywords: Urokinase receptor, Moesin, Merlin, Angiogenesis, siRNA

  5. Incidence of endophthalmitis after 23-gauge pars plana vitrectomy.

    Science.gov (United States)

    Lin, Zhong; Feng, Xiaofen; Zheng, Liya; Moonasar, Nived; Shen, Lijun; Wu, Ronghan; Chen, Feng

    2018-01-23

    Endophthalmitis is a rare but severe complication following PPV. The incidence of endophthalmitis varies between 20-gauge, 23-gauge, and 25-gauge incisions. The incidence and clinical features of endophthalmitis after 23-gauge PPV in an eye hospital in China was reported in this study. Data of the eyes that underwent 23-gauge PPV from January 2011 to December 2014 at the Eye Hospital of Wenzhou Medical University was retrospectively collected. All the information was obtained from the electronic medical system. The exclusion criteria included: (1) preoperative diagnosis of endophthalmitis; (2) history of vitrectomy; (3) intraocular surgery within 6 months; (4) history of ocular penetrating trauma; (5) sutures for any of the 3 sclerotomy incisions; (6) patients with cancer, acquired immune deficiency syndrome, or taking drugs that may influence the immune system. The diagnosis of endophthalmitis was based on clinical characteristics and/or culture results from an operative sample. Three thousand nine hundred seventy nine eyes that underwent 23-gauge PPV surgery were included in this study. Among these eyes, 3 eyes developed endophthalmitis after surgery, giving an incidence of 0.075% (3/3979). The period in which endophthalmitis developed ranged from 1 to 5 days post-operation. The visual acuity decreased to hand motions or light perception postoperatively. The culture of aqueous and vitreous of the 2 eyes revealed Staphylococcus epidermidis and enterococcus faecalis respectively, however was negative for the third eye. All 3 eyes had a favorable response to the treatment of vitreous tap and intravitreal antibiotics injection. Two eyes gained visual acuity of 0.05 and 0.5, respectively at the final visit. Endophthalmitis is a rare but sight-threatening complication after 23-gauge pars plana vitrectomy. The peak duration of onset was within 5 days post-operation, with gram positive cocci being the common pathogenic organism.

  6. La relecture du romancero par les vihuelistes de la Renaissance

    Directory of Open Access Journals (Sweden)

    Pascal Martel

    1999-01-01

    Full Text Available Les romances espagnols de la Reconquête relataient sur le mode épique des faits passés sur une mélodie récurrente qui servait surtout d’outil mnémotechnique pour réciter de longues narrations. Lorsque Diego Pisador reprend un romance, il n’en prend que quelques vers : du coup, le rapport entre les mots et les notes se fait plus étroit. D’un poème épique, il élabore une amplification lyrique, une véritable composition musicale, opère un véritable changement d’esthétique : le passage de la longue narration sur un thème musical bref et récurrent qui caractérisait le romance médiéval de la Reconquista, à une forme musico-littéraire plus brève mais plus élaborée, propre à introduire la vibration lyrique dans la matière épique. Familier de la Cour, il entend ainsi servir les desseins politiques de Philippe Il à qui il dédie son œuvre : le compositeur vihueliste qu’était Pisador en effet participe à l’effort de l’intégration du Maure poursuivi par la politique de la Maison d’Autriche. Mais les noces n’eurent pas lieu et les Maures furent au contraire expulsés en 1609. L’analyse de cette chanson nous donne l’occasion de découvrir les moyens employés par le musicien pour se livrer à une véritable amplification lyrique d’un simple récit par la musique. La chanson savante n’est pas non plus une composition dans laquelle la mélodie traduirait simplement en musique le texte poétique de façon tout à fait parallèle : la musique n’est pas qu’une répétition, sous une autre forme, de la parole, ou bien l’image sonore d’un texte. Musique et poésie constituent deux moyens autonomes d’expression mais qui, dans une chanson, concourent à un même but : ces deux moyens d’expression tantôt se rejoignant, tantôt s’émancipant l’un de l’autre, de sorte que le propre de la chanson réside justement dans cette tension constante entre ses deux composantes. La mise en musique

  7. A mechanism for ParB-dependent waves of ParA, a protein related to DNA segregation during cell division in prokaryotes

    DEFF Research Database (Denmark)

    Hunding, Axel; Gerdes, Kenn; Charbon, Gitte Ebersbach

    2003-01-01

    Prokaryotic plasmids encode partitioning (par) loci involved in segregation of DNA to daughter cells at cell division. A functional fusion protein consisting of Walker-type ParA ATPase and green fluorescent protein (Gfp) oscillates back and forth within nucleoid regions with a wave period of abou...... in an autocatalytic process. We discuss this mechanism in relation to recent models for MinDE oscillations in E.coli and to microtubule degradation in mitosis. The study points to an ancestral role for the presented pattern types in generating bipolarity in prokaryotes and eukaryotes....

  8. Developpement de techniques de diagnostic non intrusif par tomographie optique

    Science.gov (United States)

    Dubot, Fabien

    Que ce soit dans les domaines des procedes industriels ou de l'imagerie medicale, on a assiste ces deux dernieres decennies a un developpement croissant des techniques optiques de diagnostic. L'engouement pour ces methodes repose principalement sur le fait qu'elles sont totalement non invasives, qu'elle utilisent des sources de rayonnement non nocives pour l'homme et l'environnement et qu'elles sont relativement peu couteuses et faciles a mettre en oeuvre comparees aux autres techniques d'imagerie. Une de ces techniques est la Tomographie Optique Diffuse (TOD). Cette methode d'imagerie tridimensionnelle consiste a caracteriser les proprietes radiatives d'un Milieu Semi-Transparent (MST) a partir de mesures optiques dans le proche infrarouge obtenues a l'aide d'un ensemble de sources et detecteurs situes sur la frontiere du domaine sonde. Elle repose notamment sur un modele direct de propagation de la lumiere dans le MST, fournissant les predictions, et un algorithme de minimisation d'une fonction de cout integrant les predictions et les mesures, permettant la reconstruction des parametres d'interet. Dans ce travail, le modele direct est l'approximation diffuse de l'equation de transfert radiatif dans le regime frequentiel tandis que les parametres d'interet sont les distributions spatiales des coefficients d'absorption et de diffusion reduit. Cette these est consacree au developpement d'une methode inverse robuste pour la resolution du probleme de TOD dans le domaine frequentiel. Pour repondre a cet objectif, ce travail est structure en trois parties qui constituent les principaux axes de la these. Premierement, une comparaison des algorithmes de Gauss-Newton amorti et de Broyden- Fletcher-Goldfarb-Shanno (BFGS) est proposee dans le cas bidimensionnel. Deux methodes de regularisation sont combinees pour chacun des deux algorithmes, a savoir la reduction de la dimension de l'espace de controle basee sur le maillage et la regularisation par penalisation de Tikhonov

  9. A biomechanic study of the surgical repair technique of pars defect in spondylolysis.

    Science.gov (United States)

    Vathana, P; Prasartritha, T

    1998-11-01

    To find out which wiring technique of direct repair of the pars defect is the strongest in resisting anteroposterior translation displacement, fifteen fresh human cadaveric L4-L5 spines were biomechanically tested by a universal testing machine. Two millimeters wide pars defect was created on both sides of L4 vertebrae. Each of the five specimens was wired using Nicol's technique (A), modified Nicol's technique (B) and modified pedicular screw technique respectively (C). At each test, motion was observed to occur initially at the pars defect. The mean minimum tensile strength (increment of the pars defect) for technique A, B and C was 87.64, 82.04 and 110.08 Kg Force respectively. By statistical analysis, technique C was the strongest in resisting anteroposterior displacement of the spinal column. There was no statistically significant difference between technique A and B.

  10. Remote sensing of global surface shortwave radiation and PAR over the ocean

    Science.gov (United States)

    Gautier, Catherine H.; Byers, Michael L.

    1992-12-01

    During the past few years many methods have been proposed for estimating surface radiative fluxes (shortwave radiation, photosynthetically active radiation - PAR) from satellite observations. We have developed algorithms for computing the shortwave radiative flux (shortwave irradiance) at the ocean surface from visible radiance observations and they have been found to be quite successful under most atmospheric and cloud conditions. For broken clouds, however, the simple plane parallel assumption for solving the radiative transfer equations may need to be corrected to account for cloud geometry. The estimation of PAR is simpler because the most commonly used satellite radiance measurements cover a similar region of the solar spectrum. We are in the process of producing global $ARDNSW and PAR as a contribution to the Sequoia 2000 project (to implement a distributed processing system designed for the needs of global change researchers). Results from our algorithms developed for Sequoia and preliminary global surface solar irradiance and PAR fields are presented and discussed.

  11. Disjonction symphysaire après un accouchement par voie basse ...

    African Journals Online (AJOL)

    Disjonction symphysaire après un accouchement par voie basse dystocique: à propos d'un cas. Meriem Laadioui, Wafae Slimani, Sofia Jayi, Fatimazahra Fdili Alaoui, Hakima Bouguern, Hikmat Chaara, Moulay Aabdelilah Melhouf ...

  12. ParTIES: a toolbox for Paramecium interspersed DNA elimination studies.

    Science.gov (United States)

    Denby Wilkes, Cyril; Arnaiz, Olivier; Sperling, Linda

    2016-02-15

    Developmental DNA elimination occurs in a wide variety of multicellular organisms, but ciliates are the only single-celled eukaryotes in which this phenomenon has been reported. Despite considerable interest in ciliates as models for DNA elimination, no standard methods for identification and characterization of the eliminated sequences are currently available. We present the Paramecium Toolbox for Interspersed DNA Elimination Studies (ParTIES), designed for Paramecium species, that (i) identifies eliminated sequences, (ii) measures their presence in a sequencing sample and (iii) detects rare elimination polymorphisms. ParTIES is multi-threaded Perl software available at https://github.com/oarnaiz/ParTIES. ParTIES is distributed under the GNU General Public Licence v3. © The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

  13. Model parameterization to simulate and compare the PAR absorption potential of two competing plant species.

    Science.gov (United States)

    Bendix, Jörg; Silva, Brenner; Roos, Kristin; Göttlicher, Dietrich Otto; Rollenbeck, Rütger; Nauss, Thomas; Beck, Erwin

    2010-05-01

    Mountain pastures dominated by the pasture grass Setaria sphacelata in the Andes of southern Ecuador are heavily infested by southern bracken (Pteridium arachnoideum), a major problem for pasture management. Field observations suggest that bracken might outcompete the grass due to its competitive strength with regard to the absorption of photosynthetically active radiation (PAR). To understand the PAR absorption potential of both species, the aims of the current paper are to (1) parameterize a radiation scheme of a two-big-leaf model by deriving structural (LAI, leaf angle parameter) and optical (leaf albedo, transmittance) plant traits for average individuals from field surveys, (2) to initialize the properly parameterized radiation scheme with realistic global irradiation conditions of the Rio San Francisco Valley in the Andes of southern Ecuador, and (3) to compare the PAR absorption capabilities of both species under typical local weather conditions. Field data show that bracken reveals a slightly higher average leaf area index (LAI) and more horizontally oriented leaves in comparison to Setaria. Spectrometer measurements reveal that bracken and Setaria are characterized by a similar average leaf absorptance. Simulations with the average diurnal course of incoming solar radiation (1998-2005) and the mean leaf-sun geometry reveal that PAR absorption is fairly equal for both species. However, the comparison of typical clear and overcast days show that two parameters, (1) the relation of incoming diffuse and direct irradiance, and (2) the leaf-sun geometry play a major role for PAR absorption in the two-big-leaf approach: Under cloudy sky conditions (mainly diffuse irradiance), PAR absorption is slightly higher for Setaria while under clear sky conditions (mainly direct irradiance), the average bracken individual is characterized by a higher PAR absorption potential. (approximately 74 MJ m(-2) year(-1)). The latter situation which occurs if the maximum daily

  14. ParFit: A Python-Based Object-Oriented Program for Fitting Molecular Mechanics Parameters to ab Initio Data.

    Science.gov (United States)

    Zahariev, Federico; De Silva, Nuwan; Gordon, Mark S; Windus, Theresa L; Dick-Perez, Marilu

    2017-03-27

    A newly created object-oriented program for automating the process of fitting molecular-mechanics parameters to ab initio data, termed ParFit, is presented. ParFit uses a hybrid of deterministic and stochastic genetic algorithms. ParFit can simultaneously handle several molecular-mechanics parameters in multiple molecules and can also apply symmetric and antisymmetric constraints on the optimized parameters. The simultaneous handling of several molecules enhances the transferability of the fitted parameters. ParFit is written in Python, uses a rich set of standard and nonstandard Python libraries, and can be run in parallel on multicore computer systems. As an example, a series of phosphine oxides, important for metal extraction chemistry, are parametrized using ParFit. ParFit is in an open source program available for free on GitHub ( https://github.com/fzahari/ParFit ).

  15. Tsitutu , ou mecanisme local de mediation et de reconciliation « par ...

    African Journals Online (AJOL)

    Si le Togo est une nation pluriethnique, du coup, il y en aura des manières particulières de résolution des conflits, donc des réconciliations. Par une approche pluridisciplinaire, cette étude a pour but de restituer le mécanisme local de réconciliation chez les ewe de Kloto. Par ailleurs, ce rituel qui tente de proposer des ...

  16. La base de données sur les femmes entrepreneures soutenue par ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    6 août 2017 ... L'inclusion des femmes dans une base de données qui comprend des entreprises dirigées par des femmes les aidera énormément », ajoute-t-elle. Le CRDI appuie WEConnect dans l'auto-inscription et la certification électronique des entreprises dirigées par des femmes de toutes tailles qui ont besoin ...

  17. Etude par simulation hil des performances d'un statcom pour la ...

    African Journals Online (AJOL)

    Ce travail présente l'étude par simulation Hardware In the Loop (HIL) des performances d'un STATCOM pour la stabilisation de la tension délivrée par une génératrice asynchrone triphasée auto excitée dans un réseau autonome. Nous avons combiné l'utilisation du logiciel de simulation LABVIEW et la carte ARDUINO ...

  18. Infection par le VIH chez les patientes atteintes de cancer du sein en ...

    African Journals Online (AJOL)

    L'objectif était de déterminer la prévalence de l'infection à VIH chez les patientes atteintes de cancer du sein et de comparer les caractéristiques anatomocliques et thérapeutiques de ces cancers du sein par rapports aux patientes non infectées par le VIH. Il s'agissait d'une étude rétrospective et analytique comparant les ...

  19. Les corps etrangers des fosses nasales: Extraction par la pince d ...

    African Journals Online (AJOL)

    Les corps etrangers des fosses nasales: Extraction par la pince d'halsteaD. ... des fosses nasales: Extraction par la pince d'halsteaD. B Amana, E Kpemissi, P Agoda, A Naba-Mouchedou ... Les corps étrangers des fosses nasales représentent 0,94 % des consultations ORL du service. L'âge des patients a varié de 9 mois à ...

  20. La prise en charge des suicides par précipitation en traumatologie ...

    African Journals Online (AJOL)

    Introduction: A travers ce travail, l'épidémiologie et la psychopathologie du suicide par précipitation seront rappelées, le rôle du chirurgien traumatologue dans la restauration physique et psychique sera démontré. Méthodes: Nous rapportons une étude rétrospective de 15 suicidants par précipitation admis pour des ...

  1. Elimination du cadmium de l'acide phosphorique par électrodialyse

    African Journals Online (AJOL)

    L'efficacité d'élimination obtenue (31.4%) peut être améliorée par l'optimisation des autres paramètres tels que l'utilisation d'autres types de membranes. REFERENCES. [1] Boussen R., 2007. valorisation de l'acide phosphorique par precipitation du cadmium et pertraction de l'uranium. Thèse de doctorat d'état en chimie ...

  2. The superoxide scavenger TEMPOL induces urokinase receptor (uPAR expression in human prostate cancer cells

    Directory of Open Access Journals (Sweden)

    Francis Joseph

    2006-06-01

    Full Text Available Abstract There is little understanding of the effect that reactive oxygen metabolites have on cellular behavior during the processes of invasion and metastasis. These oxygen metabolites could interact with a number of targets modulating their function such as enzymes involved in basement membrane dissolution, adhesion molecules involved in motility or receptors involved in proliferation. We investigated the effect of increased scavenging of superoxide anions on the expression of the urokinase receptor (uPAR in PC-3M human prostate cancer cells. Urokinase receptor is a GPI-linked cell surface molecule which mediates multiple functions including adhesion, proliferation and pericellular proteolysis. Addition of the superoxide scavenger 4-hydroxy-2,2,6,6-tetramethylpiperidinyloxy (TEMPOL to PC-3M cultures stimulated expression of uPAR protein peaking between 48 and 72 hours. Cell surface expression of the uPAR was also increased. Surprisingly, uPAR transcript levels increased only slightly and this mild increase did not coincide with the striking degree of protein increase. This disparity indicates that the TEMPOL effect on uPAR occurs through a post-transcriptional mechanism. TEMPOL presence in PC-3M cultures reduced intracellular superoxide-type species by 75% as assayed by NBT dye conversion; however this reduction significantly diminished within hours following TEMPOL removal. The time gap between TEMPOL treatment and peak uPAR protein expression suggests that reduction of reactive oxygen metabolites in prostate cancer cells initiates a multistep pathway which requires several hours to culminate in uPAR induction. These findings reveal a novel pathway for uPAR regulation involving reactive oxygens such as superoxide anion.

  3. Compression robuste du signal par la transformée avec les B ...

    African Journals Online (AJOL)

    Par contre, elle diminue de façon considérable pour les b-splincs et les paquets dbndelcttes de Haar. Du point de vue entropie, la compression par bfsplines est bonne que celle de la TCD. Nous donnons ci-dessous un tableau récapitulatif des résultats de quelques méthodes utilisées pour deux signaux EMG. Le facteur de ...

  4. Le Sri Lanka mieux préparé aux futurs tsunamis | CRDI - Centre de ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    9 nov. 2012 ... Comme le rappelle Rohan Samarajiva, président du conseil d'administration et directeur général de LIRNEasia, ces essais ont révélé que la radio par satellite « adressable » était la technologie la plus fiable. Malheureusement, la faillite de la seule société de radiodiffusion par satellite en Asie a fait en ...

  5. Diagnostic moléculaire d'helicobacter pylori par PCR chez les ...

    African Journals Online (AJOL)

    Résultats: Les pathologies gastroduodénales étaient plus fréquentes chez les patients de plus de 45 ans. Les prévalences de H. pylori étaient respectivement de 88,57% et de 91,43% par sérologie Immunocomb et par PCR. La différence entre les deux techniques n'était pas significative (P = 0,573). La performance de la ...

  6. Erythroblastopénie induite par la grossesse: à propos d'un cas et ...

    African Journals Online (AJOL)

    Erythroblastopénie induite par la grossesse: à propos d'un cas et revue de la littérature. Drissi Jihad, Kouach Jaouad, Moussaoui Driss, Dehayni Mohamed. Abstract. L'érythroblastopénie induite par la grossesse est une entité pathologique exceptionnelle dont seuls quelques cas isolés ont été décrits dans la littérature ...

  7. Brésil : La contamination par le mercure en Amazonie | CRDI ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    11 janv. 2011 ... ... site d'extraction de l'or. À sa grande surprise, ils sont demeurés stables jusqu'à 400 km du site. De toute évidence, même si l'extraction aurifère contribuait à la contamination par le mercure jusqu'à 50 km autour de la mine, elle n'était pas la principale cause de pollution par le mercure des cours d'eau en ...

  8. Prise en charge du spondylolisthesis par lyse isthmique a niamey, a ...

    African Journals Online (AJOL)

    Objectif Evaluer la prise en charge chirurgicale du spondylolisthésis par lyse isthmique à Niamey. Méthode Etude prospective en série continue réalisée dans le service de Neurochirurgie de Niamey de Janvier 1999 à Janvier 2006. Etaient inclus les spondylolisthésis par lyse isthmique. Les spondylolisthésis étaient ...

  9. L'émancipation des femmes et des collectivités africaines par l ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    23 nov. 2011 ... Ce que les chercheurs n'ont pas saisi dans le cas de Mercy, par exemple, c'est que les femmes perdent souvent le contrôle de la situation lorsque le fruit de leur labeur entre dans les systèmes financiers et marchés officiels, qui sont principalement régis par des hommes. Mme Njuki a découvert un ...

  10. Diffraction de rayons X sur les plaquettes de fer durcies par cyanuration

    Science.gov (United States)

    Popescu, M.; Hoyer, W.; Stegarescu, M.; Cornet, A.; Broll, N.

    2004-11-01

    Une méthode de cyanuration a été developpée pour les surfaces des plaquettes de fer, basée sur une réaction thermochimique qui conduit à la formation des couches dures sur le métal. Les échantillons ont été analysés, pour de temps différents de traitement, par diffraction de rayons X et par mesures de dureté.

  11. maladie de forestier revelee par une dysphagie a propos de deux cas

    African Journals Online (AJOL)

    18 juin 2007 ... L'imagerie par résonance magnétique (IRM) est indiquée en cas de complications neurologiques. Le transit oesophagien est demandé dans le cadre de l'ex- ploration d'une dysphagie (3). Le diagnostic de la maladie de Forestier se base sur des critères radiologiques établis par Resnick et al. (8) dans les.

  12. The RNA-binding protein ATX-2 regulates cytokinesis through PAR-5 and ZEN-4.

    Science.gov (United States)

    Gnazzo, Megan M; Uhlemann, Eva-Maria E; Villarreal, Alex R; Shirayama, Masaki; Dominguez, Eddie G; Skop, Ahna R

    2016-10-15

    The spindle midzone harbors both microtubules and proteins necessary for furrow formation and the completion of cytokinesis. However, the mechanisms that mediate the temporal and spatial recruitment of cell division factors to the spindle midzone and midbody remain unclear. Here we describe a mechanism governed by the conserved RNA-binding protein ATX-2/Ataxin-2, which targets and maintains ZEN-4 at the spindle midzone. ATX-2 does this by regulating the amount of PAR-5 at mitotic structures, particularly the spindle, centrosomes, and midbody. Preventing ATX-2 function leads to elevated levels of PAR-5, enhanced chromatin and centrosome localization of PAR-5-GFP, and ultimately a reduction of ZEN-4-GFP at the spindle midzone. Codepletion of ATX-2 and PAR-5 rescued the localization of ZEN-4 at the spindle midzone, indicating that ATX-2 mediates the localization of ZEN-4 upstream of PAR-5. We provide the first direct evidence that ATX-2 is necessary for cytokinesis and suggest a model in which ATX-2 facilitates the targeting of ZEN-4 to the spindle midzone by mediating the posttranscriptional regulation of PAR-5. © 2016 Gnazzo et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

  13. Par and IR reflectance, transmittance, and absorptance of four crop canopies

    International Nuclear Information System (INIS)

    Wanjura, D.F.; Hatfield, J.L.

    1986-01-01

    Reflectance, transmittance and absorptance of electromagnetic radiation by cotton, soybeans, grain sorghum, and sunflower was measured at three growth stages in two wavebands (PAR: 0.4 to 0.7 pun and IR: 0.7 to 1.1 yim). As leaf area increased in each crop there were increases in IR reflectance and PAR absorptance and decreases in PAR reflectance and both PAR and IR transmittance. IR radiation was concentrated at the soil surface between rows by reflectance from the sides of canopies when crop cover was less than 80%. Across all crops one parameter, leaf overlap index, explained 81 and 71% of the PAR reflectance and another, crop cover, explained 86 and 94% of IR reflectance from rows and interrows, respectively. Attenuation of PAR radiation through the canopies of cotton and sunflower was similar (K = 0.62 and 0.67) but different from that of soybeans and grain sorghum (K = 0.46 and 0.43) which were the same

  14. Par6b Regulates the Dynamics of Apicobasal Polarity during Development of the Stratified Xenopus Epidermis

    Science.gov (United States)

    Wang, Sha; Cha, Sang-Wook; Zorn, Aaron M.; Wylie, Christopher

    2013-01-01

    During early vertebrate development, epithelial cells establish and maintain apicobasal polarity, failure of which can cause developmental defects or cancer metastasis. This process has been mostly studied in simple epithelia that have only one layer of cells, but is poorly understood in stratified epithelia. In this paper we address the role of the polarity protein Partitioning defective-6 homolog beta (Par6b) in the developing stratified epidermis of Xenopus laevis. At the blastula stage, animal blastomeres divide perpendicularly to the apicobasal axis to generate partially polarized superficial cells and non-polarized deep cells. Both cell populations modify their apicobasal polarity during the gastrula stage, before differentiating into the superficial and deep layers of epidermis. Early differentiation of the epidermis is normal in Par6b-depleted embryos; however, epidermal cells dissociate and detach from embryos at the tailbud stage. Par6b-depleted epidermal cells exhibit a significant reduction in basolaterally localized E-cadherin. Examination of the apical marker Crumbs homolog 3 (Crb3) and the basolateral marker Lethal giant larvae 2 (Lgl2) after Par6b depletion reveals that Par6b cell-autonomously regulates the dynamics of apicobasal polarity in both superficial and deep epidermal layers. Par6b is required to maintain the “basolateral” state in both epidermal layers, which explains the reduction of basolateral adhesion complexes and epidermal cells shedding. PMID:24204686

  15. Etiología en parálisis cerebral.

    Directory of Open Access Journals (Sweden)

    Patricia Campos

    1996-07-01

    Full Text Available Objetivo: Determinar las causas mas frecuentes de parálisis cerebral (PC. Material y métodos: Estudio descriptivo realizado en Hospital Nacional Cayetano Heredia y el Hogar Clínica San Juan de Dios (Lima-Perú, entre noviembre 1990 y mayo de 1992. Se revisaron las historias clínicas de 102 pacientes con diagnósticos de PC y se revisó las etiologías. Resultados: En relación a edad gestacional hubieron 15 casos de prematuros (14.7%, 67(65% a término y un postmaduro, en 19 no se tuvo la edad gestacional. El peso al nacer fue adecuado en 56(54.9%, bajo en 17(16.7% y muy bajo en 7(6.9%. Se identificó la causa de PC en 73/102 casos (70%, siendo las causas más frecuentes las perinatales (59.3%, seguidas de las prenatales con 29.1% y las postnatales con 11.6%. En el grupo de causas prenatales, la mitad fueron malformaciones cerebrales congénitas entre las que destaca el quiste porencefálico, presente en la mitad de estos casos. En el grupo perinatal, la más frecuente fue asfixia (83% asociada o no a otro factor metabólico. Hubieron además en este grupo 4 casos de hipoglicemia severa y 2 con encefalopatía hiperbilirrubinémica y PC distónica. Las causas postnatal más frecuente fue la meningoencefalitis bacteriana, en menores de un año de edad. Al correlacionar etiología y momento del daño, peso al nacer y tipo de PC se observa que, en los recién nacidos PT de bajo o muy bajo peso al nacer es mas frecuente la PC de tipo dipléjica y en todos el antecedente fue asfixia perinatal. Conclusiones: La baja frecuencia de PC dipléjica y la elevada frecuencia de causas perinatales (asfixia, marca nuestra diferencia con otras series y obedece en nuestra opinión, a los escasos recursos tecnológicos y las deficiencias en la atención a las gestantes y recién nacidos de nuestro sistema nacional de salud. (Rev Med Hered 1996; 7: 114-118.

  16. Modeling post-wildfire hydrological processes with ParFlow

    Science.gov (United States)

    Escobar, I. S.; Lopez, S. R.; Kinoshita, A. M.

    2017-12-01

    Wildfires alter the natural processes within a watershed, such as surface runoff, evapotranspiration rates, and subsurface water storage. Post-fire hydrologic models are typically one-dimensional, empirically-based models or two-dimensional, conceptually-based models with lumped parameter distributions. These models are useful for modeling and predictions at the watershed outlet; however, do not provide detailed, distributed hydrologic processes at the point scale within the watershed. This research uses ParFlow, a three-dimensional, distributed hydrologic model to simulate post-fire hydrologic processes by representing the spatial and temporal variability of soil burn severity (via hydrophobicity) and vegetation recovery. Using this approach, we are able to evaluate the change in post-fire water components (surface flow, lateral flow, baseflow, and evapotranspiration). This work builds upon previous field and remote sensing analysis conducted for the 2003 Old Fire Burn in Devil Canyon, located in southern California (USA). This model is initially developed for a hillslope defined by a 500 m by 1000 m lateral extent. The subsurface reaches 12.4 m and is assigned a variable cell thickness to explicitly consider soil burn severity throughout the stages of recovery and vegetation regrowth. We consider four slope and eight hydrophobic layer configurations. Evapotranspiration is used as a proxy for vegetation regrowth and is represented by the satellite-based Simplified Surface Energy Balance (SSEBOP) product. The pre- and post-fire surface runoff, subsurface storage, and surface storage interactions are evaluated at the point scale. Results will be used as a basis for developing and fine-tuning a watershed-scale model. Long-term simulations will advance our understanding of post-fire hydrological partitioning between water balance components and the spatial variability of watershed processes, providing improved guidance for post-fire watershed management. In reference

  17. ParA-like protein influences the distribution of multi-copy chromosomes in cyanobacterium Synechococcus elongatus PCC 7942.

    Science.gov (United States)

    Watanabe, Satoru; Noda, Aska; Ohbayashi, Ryudo; Uchioke, Kana; Kurihara, Ami; Nakatake, Shizuka; Morioka, Sayumi; Kanesaki, Yu; Chibazakura, Taku; Yoshikawa, Hirofumi

    2018-01-01

    While many bacteria, such as Escherichia coli and Bacillus subtilis, harbour a single-copy chromosome, freshwater cyanobacteria have multiple copies of each chromosome per cell. Although it has been reported that multi-copy chromosomes are evenly distributed along the major axis of the cell in cyanobacterium Synechococcus elongatus PCC 7942, the distribution mechanism of these chromosomes remains unclear. In S. elongatus, the carboxysome, a metabolic microcompartment for carbon fixation that is distributed in a similar manner to the multi-copy chromosomes, is regulated by ParA-like protein (hereafter ParA). To elucidate the role of ParA in the distribution of multi-copy chromosomes, we constructed and analysed ParA disruptant and overexpressing strains of S. elongatus. Our fluorescence in situ hybridization assay revealed that the parA disruptants displayed an aberrant distribution of their multi-copy chromosomes. In the parA disruptant the multiple origin and terminus foci, corresponding to the intracellular position of each chromosomal region, were aggregated, which was compensated by the expression of exogenous ParA from other genomic loci. The parA disruptant is sensitive to UV-C compared to the WT strain. Additionally, giant cells appeared under ParA overexpression at the late stage of growth indicating that excess ParA indirectly inhibits cell division. Screening of the ParA-interacting proteins by yeast two-hybrid analysis revealed four candidates that are involved in DNA repair and cell membrane biogenesis. These results suggest that ParA is involved in the pleiotropic cellular functions with these proteins, while parA is dispensable for cell viability in S. elongatus.

  18. A method for estimating the diffuse attenuation coefficient (KdPAR)from paired temperature sensors

    Science.gov (United States)

    Read, Jordan S.; Rose, Kevin C.; Winslow, Luke A.; Read, Emily K.

    2015-01-01

    A new method for estimating the diffuse attenuation coefficient for photosynthetically active radiation (KdPAR) from paired temperature sensors was derived. We show that during cases where the attenuation of penetrating shortwave solar radiation is the dominant source of temperature changes, time series measurements of water temperatures at multiple depths (z1 and z2) are related to one another by a linear scaling factor (a). KdPAR can then be estimated by the simple equation KdPAR ln(a)/(z2/z1). A suggested workflow is presented that outlines procedures for calculating KdPAR according to this paired temperature sensor (PTS) method. This method is best suited for conditions when radiative temperature gains are large relative to physical noise. These conditions occur frequently on water bodies with low wind and/or high KdPARs but can be used for other types of lakes during time periods of low wind and/or where spatially redundant measurements of temperatures are available. The optimal vertical placement of temperature sensors according to a priori knowledge of KdPAR is also described. This information can be used to inform the design of future sensor deployments using the PTS method or for campaigns where characterizing sub-daily changes in temperatures is important. The PTS method provides a novel method to characterize light attenuation in aquatic ecosystems without expensive radiometric equipment or the user subjectivity inherent in Secchi depth measurements. This method also can enable the estimation of KdPAR at higher frequencies than many manual monitoring programs allow.

  19. Clathrin and LRP-1-independent constitutive endocytosis and recycling of uPAR.

    Directory of Open Access Journals (Sweden)

    Katia Cortese

    Full Text Available BACKGROUND: The urokinase receptor (uPAR/CD87 is highly expressed in malignant tumours. uPAR, as a GPI anchored protein, is preferentially located at the cell surface, where it interacts with its ligands urokinase (uPA and the extracellular matrix protein vitronectin, thus promoting plasmin generation, cell-matrix interactions and intracellular signalling events. Interaction with a complex formed by uPA and its inhibitor PAI-1 induces cell surface down regulation and recycling of the receptor via the clathrin-coated pathway, a process dependent on the association to LRP-1. METHODOLOGY/PRINCIPAL FINDINGS: In this study, we have found that along with the ligand-induced down-regulation, uPAR also internalizes and recycles constitutively through a second pathway that is independent of LRP-1 and clathrin but shares some properties with macropinocytosis. The ligand-independent route is amiloride-sensitive, does not require uPAR partitioning into lipid rafts, is independent of the activity of small GTPases RhoA, Rac1 and Cdc42, and does not require PI3K activity. Constitutively endocytosed uPAR is found in EEA1 positive early/recycling endosomes but does not reach lysosomes in the absence of ligands. Electron microscopy analysis reveals the presence of uPAR in ruffling domains at the cell surface, in macropinosome-like vesicles and in endosomal compartments. CONCLUSIONS/SIGNIFICANCE: These results indicate that, in addition to the ligand-induced endocytosis of uPAR, efficient surface expression and membrane trafficking might also be driven by an uncommon macropinocytic mechanism coupled with rapid recycling to the cell surface.

  20. Evaluation of treatment and posttreatment changes of protraction facemask treatment using the PAR index.

    Science.gov (United States)

    Ngan, P; Yiu, C

    2000-10-01

    The purpose of this study was to use the Peer Assesment Rating (PAR) index score to evaluate the treatment and posttreatment changes of Class III patients treated by protraction facemask. The sample consisted of 20 Chinese children, 6 to 11 years old, with Class III skeletal malocclusion who had been treated with maxillary expansion and a protraction facemask. The average treatment time was 8.2 months, followed by 1 year of retention with a Class III functional appliance. Study casts were taken pretreatment (T1), posttreatment (T2), 1 year follow-up (T3), and 2 years follow-up (T4). After treatment, PAR scores were calculated for each time period. Differences among the 4 time periods were analyzed with the Wilcoxin matched-pairs test. Significant reductions in PAR scores were found at T2 (56%), T3 (70%), and T4 (63%) compared with T1. Immediately posttreatment (T2), 17 (85%) of 20 patients had improved PAR scores by a reduction of at least 30%. Reductions were caused primarily by correction of the anterior crossbite. One year after treatment (T3), further reductions in PAR score were noted (P <.01) as a result of better alignment of the anterior segment, improvement of the buccal occlusion, and overbite and midline corrections. Two years after treatment (T4), PAR scores were higher than at the previous time period. The increases were due to relapses in overjet (4 of 20 patients), overbite, and centerline corrections. These results indicate that significant reductions in the severity of Class III malocclusion can be achieved with early orthopedic facemask treatment. In most cases, further improvement in the PAR score can be expected 1 and 2 years after treatment. In a few patients, the benefits of early treatment are negated by relapses in overjet, overbite, and centerline corrections during the follow-up period.

  1. Lumbar lordosis and pars interarticularis fractures: a case-control study

    International Nuclear Information System (INIS)

    Bugg, William G.; Lewis, Mark; Juette, Arne; Cahir, John G.; Toms, Andoni P.

    2012-01-01

    The aim of this study is to examine the relationship between lumbar lordosis and pars interarticularis fractures. In this retrospective case-control study we compare the angle of lumbar lordosis and the angle of the S1 vertebral endplate (as a measure of pelvic tilt) in patients with bilateral L5 pars interarticularis fractures with age- and sex-matched control cases with normal MRI examinations of the lumbar spine. Twenty-nine cases of bilateral L5 pars interarticularis fractures with matched control-cases were identified on MRI (16 male, 13 female, age 9-63 years). The angle of lordosis was measured between the inferior L4 and superior S1 vertebral endplates on a standing lateral lumbar spine radiograph for both groups. The mean angle of lordosis about the L5 vertebra was 36.9 (SD = 6.5 ) in the pars interarticularis fracture group, and 30.1 (SD = 6.4 ) in the control group. The difference between the two groups was significant (mean difference 6.8 , Student's t test: P < 0.001). The mean angle of sacral tilt measured was 122.2 (SD = 10.16 ) for controls and 136.4 (SD = 10.86 ) for patients with pars defects. The difference in the means of 14.2 was statistically significantly different (P < 0.0001). Sacral tilt represented by a steeply angled superior endplate of S1 is associated with a significantly increased angle of lordosis, between L4 and S1, and pars fractures at L5. Steep angulation of the first sacral vertebral segment maybe the predisposing biomechanical factor that leads to pincer-like impingement of the pars interarticularis and then spondylolysis. (orig.)

  2. Lumbar lordosis and pars interarticularis fractures: a case-control study

    Energy Technology Data Exchange (ETDEWEB)

    Bugg, William G.; Lewis, Mark; Juette, Arne; Cahir, John G.; Toms, Andoni P. [Cotman Centre, Norwich Radiology Academy, Norwich, Norfolk (United Kingdom)

    2012-07-15

    The aim of this study is to examine the relationship between lumbar lordosis and pars interarticularis fractures. In this retrospective case-control study we compare the angle of lumbar lordosis and the angle of the S1 vertebral endplate (as a measure of pelvic tilt) in patients with bilateral L5 pars interarticularis fractures with age- and sex-matched control cases with normal MRI examinations of the lumbar spine. Twenty-nine cases of bilateral L5 pars interarticularis fractures with matched control-cases were identified on MRI (16 male, 13 female, age 9-63 years). The angle of lordosis was measured between the inferior L4 and superior S1 vertebral endplates on a standing lateral lumbar spine radiograph for both groups. The mean angle of lordosis about the L5 vertebra was 36.9 (SD = 6.5 ) in the pars interarticularis fracture group, and 30.1 (SD = 6.4 ) in the control group. The difference between the two groups was significant (mean difference 6.8 , Student's t test: P < 0.001). The mean angle of sacral tilt measured was 122.2 (SD = 10.16 ) for controls and 136.4 (SD = 10.86 ) for patients with pars defects. The difference in the means of 14.2 was statistically significantly different (P < 0.0001). Sacral tilt represented by a steeply angled superior endplate of S1 is associated with a significantly increased angle of lordosis, between L4 and S1, and pars fractures at L5. Steep angulation of the first sacral vertebral segment maybe the predisposing biomechanical factor that leads to pincer-like impingement of the pars interarticularis and then spondylolysis. (orig.)

  3. Identification of a new epitope in uPAR as a target for the cancer therapeutic monoclonal antibody ATN-658, a structural homolog of the uPAR binding integrin CD11b (αM.

    Directory of Open Access Journals (Sweden)

    Xiang Xu

    Full Text Available The urokinase plasminogen activator receptor (uPAR plays a role in tumor progression and has been proposed as a target for the treatment of cancer. We recently described the development of a novel humanized monoclonal antibody that targets uPAR and has anti-tumor activity in multiple xenograft animal tumor models. This antibody, ATN-658, does not inhibit ligand binding (i.e. uPA and vitronectin to uPAR and its mechanism of action remains unclear. As a first step in understanding the anti-tumor activity of ATN-658, we set out to identify the epitope on uPAR to which ATN-658 binds. Guided by comparisons between primate and human uPAR, epitope mapping studies were performed using several orthogonal techniques. Systematic site directed and alanine scanning mutagenesis identified the region of aa 268-275 of uPAR as the epitope for ATN-658. No known function has previously been attributed to this epitope Structural insights into epitope recognition were obtained from structural studies of the Fab fragment of ATN-658 bound to uPAR. The structure shows that the ATN-658 binds to the DIII domain of uPAR, close to the C-terminus of the receptor, corroborating the epitope mapping results. Intriguingly, when bound to uPAR, the complementarity determining region (CDR regions of ATN-658 closely mimic the binding regions of the integrin CD11b (αM, a previously identified uPAR ligand thought to be involved in leukocyte rolling, migration and complement fixation with no known role in tumor progression of solid tumors. These studies reveal a new functional epitope on uPAR involved in tumor progression and demonstrate a previously unrecognized strategy for the therapeutic targeting of uPAR.

  4. L’usage de Twitter par les maires d’Île-de-France

    Directory of Open Access Journals (Sweden)

    Nicolas Douay

    2016-05-01

    Full Text Available Cet article propose de visualiser des données numériques produites par l’usage du réseau social Twitter par les maires de la région Ile-de-France. En effet Twitter est maintenant un outil de communication en pleine expansion et les personnalités publiques l’utilisent abondamment comme un moyen de rejoindre les internautes intéressés par leurs engagements et responsabilités. L’analyse et la visualisation de ces « big data » visent donc à réaliser une étude de l’usage d’un réseau social par des élus locaux. Il s’agit, d’abord, de dresser le profil type des maires présents sur le réseau social en fonction du genre, de l’âge, de l’appartenance partisane, du niveau de responsabilité et du type d’espace. Puis de caractériser les usages quant à l’audience et au rayonnement de l’activité par l’analyse du nombre de tweets et des followers en reprenant les mêmes critères. Et enfin, il s’agit d’observer le contenu des messages échangés et de les analyser comme des illustrations du débat public local.

  5. Valproate alters dopamine signaling in association with induction of Par-4 protein expression.

    Directory of Open Access Journals (Sweden)

    Saebom Lee

    Full Text Available Chromatin remodeling through histone modifications has emerged as a key mechanism in the pathophysiology of psychiatric disorders. Valproate (VPA, a first-line medication for bipolar disorder, is known to have histone deacetylase (HDAC inhibitor activity, but the relationship between its efficacy as a mood stabilizer and HDAC inhibitory activity is unclear. Here we provide evidence that prostate apoptosis response-4 (Par-4, an intracellular binding partner of dopamine D2 receptors (DRD2, plays a role in mediating the effectiveness of VPA. We found that chronic VPA treatment enhanced the expression of Par-4 in cultured neurons and adult mouse brains. This Par-4 induction phenomenon occurred at the transcriptional level and was correlated with an increase in histone H3 and H4 acetylation of the Par-4 promoter regions. Furthermore, chronic VPA treatment potentiated the suppression of the cAMP signaling cascade upon dopamine stimulation, which was blocked by sulpiride treatment. These results indicate that VPA potentiates DRD2 activity by enhancing Par-4 expression via a chromatin remodeling mechanism.

  6. Nanomechanical recognition of prognostic biomarker suPAR with DVD-ROM optical technology.

    Science.gov (United States)

    Bache, Michael; Bosco, Filippo G; Brøgger, Anna L; Frøhling, Kasper B; Alstrøm, Tommy Sonne; Hwu, En-Te; Chen, Ching-Hsiu; Eugen-Olsen, Jesper; Hwang, Ing-Shouh; Boisen, Anja

    2013-11-08

    In this work the use of a high-throughput nanomechanical detection system based on a DVD-ROM optical drive and cantilever sensors is presented for the detection of urokinase plasminogen activator receptor inflammatory biomarker (uPAR). Several large scale studies have linked elevated levels of soluble uPAR (suPAR) to infectious diseases, such as HIV, and certain types of cancer. Using hundreds of cantilevers and a DVD-based platform, cantilever deflection response from antibody-antigen recognition is investigated as a function of suPAR concentration. The goal is to provide a cheap and portable detection platform which can carry valuable prognostic information. In order to optimize the cantilever response the antibody immobilization and unspecific binding are initially characterized using quartz crystal microbalance technology. Also, the choice of antibody is explored in order to generate the largest surface stress on the cantilevers, thus increasing the signal. Using optimized experimental conditions the lowest detectable suPAR concentration is currently around 5 nM. The results reveal promising research strategies for the implementation of specific biochemical assays in a portable and high-throughput microsensor-based detection platform.

  7. PAR-1 mediated apoptosis of breast cancer cells by V. cholerae hemagglutinin protease.

    Science.gov (United States)

    Ray, Tanusree; Pal, Amit

    2016-05-01

    Bacterial toxins have emerged as promising agents in cancer treatment strategy. Hemagglutinin (HAP) protease secreted by Vibrio cholerae induced apoptosis in breast cancer cells and regresses tumor growth in mice model. The success of novel cancer therapies depends on their selectivity for cancer cells with limited toxicity for normal tissues. Increased expression of Protease Activated Receptor-1 (PAR-1) has been reported in different malignant cells. In this study we report that HAP induced activation and over expression of PAR-1 in breast cancer cells (EAC). Immunoprecipitation studies have shown that HAP specifically binds with PAR-1. HAP mediated activation of PAR-1 caused nuclear translocation of p50-p65 and the phosphorylation of p38 which triggered the activation of NFκB and MAP kinase signaling pathways. These signaling pathways enhanced the cellular ROS level in malignant cells that induced the intrinsic pathway of cell apoptosis. PAR-1 mediated apoptosis by HAP of malignant breast cells without effecting normal healthy cells in the same environment makes it a good therapeutic agent for treatment of cancer.

  8. Nanomechanical recognition of prognostic biomarker suPAR with DVD-ROM optical technology

    International Nuclear Information System (INIS)

    Bache, Michael; Bosco, Filippo G; Brøgger, Anna L; Frøhling, Kasper B; Boisen, Anja; Alstrøm, Tommy Sonne; Hwu, En-Te; Chen, Ching-Hsiu; Hwang, Ing-Shouh; Eugen-Olsen, Jesper

    2013-01-01

    In this work the use of a high-throughput nanomechanical detection system based on a DVD-ROM optical drive and cantilever sensors is presented for the detection of urokinase plasminogen activator receptor inflammatory biomarker (uPAR). Several large scale studies have linked elevated levels of soluble uPAR (suPAR) to infectious diseases, such as HIV, and certain types of cancer. Using hundreds of cantilevers and a DVD-based platform, cantilever deflection response from antibody–antigen recognition is investigated as a function of suPAR concentration. The goal is to provide a cheap and portable detection platform which can carry valuable prognostic information. In order to optimize the cantilever response the antibody immobilization and unspecific binding are initially characterized using quartz crystal microbalance technology. Also, the choice of antibody is explored in order to generate the largest surface stress on the cantilevers, thus increasing the signal. Using optimized experimental conditions the lowest detectable suPAR concentration is currently around 5 nM. The results reveal promising research strategies for the implementation of specific biochemical assays in a portable and high-throughput microsensor-based detection platform. (paper)

  9. Participatory action research (PAR) in middle school: opportunities, constraints, and key processes.

    Science.gov (United States)

    Ozer, Emily J; Ritterman, Miranda L; Wanis, Maggie G

    2010-09-01

    Late childhood and early adolescence represent a critical transition in the developmental and academic trajectory of youth, a time in which there is an upsurge in academic disengagement and psychopathology. PAR projects that can promote youth's sense of meaningful engagement in school and a sense of efficacy and mattering can be particularly powerful given the challenges of this developmental stage. In the present study, we draw on data from our own collaborative implementation of PAR projects in secondary schools to consider two central questions: (1) How do features of middle school settings and the developmental characteristics of the youth promote or inhibit the processes, outcomes, and sustainability of the PAR endeavor? and (2) How can the broad principles and concepts of PAR be effectively translated into specific intervention activities in schools, both within and outside of the classroom? In particular, we discuss a participatory research project conducted with 6th and 7th graders at an urban middle school as a means of highlighting the opportunities, constraints, and lessons learned in our efforts to contribute to the high-quality implementation and evaluation of PAR in diverse urban public schools.

  10. Active zone proteins are transported via distinct mechanisms regulated by Par-1 kinase.

    Directory of Open Access Journals (Sweden)

    Kara R Barber

    2017-02-01

    Full Text Available Disruption of synapses underlies a plethora of neurodevelopmental and neurodegenerative disease. Presynaptic specialization called the active zone plays a critical role in the communication with postsynaptic neuron. While the role of many proteins at the active zones in synaptic communication is relatively well studied, very little is known about how these proteins are transported to the synapses. For example, are there distinct mechanisms for the transport of active zone components or are they all transported in the same transport vesicle? Is active zone protein transport regulated? In this report we show that overexpression of Par-1/MARK kinase, a protein whose misregulation has been implicated in Autism spectrum disorders (ASDs and neurodegenerative disorders, lead to a specific block in the transport of an active zone protein component- Bruchpilot at Drosophila neuromuscular junctions. Consistent with a block in axonal transport, we find a decrease in number of active zones and reduced neurotransmission in flies overexpressing Par-1 kinase. Interestingly, we find that Par-1 acts independently of Tau-one of the most well studied substrates of Par-1, revealing a presynaptic function for Par-1 that is independent of Tau. Thus, our study strongly suggests that there are distinct mechanisms that transport components of active zones and that they are tightly regulated.

  11. MARK/Par1 Kinase Is Activated Downstream of NMDA Receptors through a PKA-Dependent Mechanism.

    Directory of Open Access Journals (Sweden)

    Laura P Bernard

    Full Text Available The Par1 kinases, also known as microtubule affinity-regulating kinases (MARKs, are important for the establishment of cell polarity from worms to mammals. Dysregulation of these kinases has been implicated in autism, Alzheimer's disease and cancer. Despite their important function in health and disease, it has been unclear how the activity of MARK/Par1 is regulated by signals from cell surface receptors. Here we show that MARK/Par1 is activated downstream of NMDA receptors in primary hippocampal neurons. Further, we show that this activation is dependent on protein kinase A (PKA, through the phosphorylation of Ser431 of Par4/LKB1, the major upstream kinase of MARK/Par1. Together, our data reveal a novel mechanism by which MARK/Par1 is activated at the neuronal synapse.

  12. Intérêt de la thérapie antivirale par voie orale dans le traitement des ...

    African Journals Online (AJOL)

    Chez les patients immunodéprimés, les complications de l'ARN syndrome conduisent souvent à une perte d'acuité visuelle. La confirmation de ce diagnostic dès la découverte de la maladie par la réaction de polymérase en chaîne (PCR) et par le coefficient de charge immunitaire (CCI) le plus souvent par ponction ...

  13. Ataque de viento externo con manifestaciones de parálisis facial periférica tratado con acupuntura

    OpenAIRE

    Pinzón Ramírez, Betty Alejandra

    2012-01-01

    El ataque de viento externo es considerado desde la medicina china como un síndrome patológico que puede cursar con manifestaciones de parálisis facial semejante a la parálisis de Bell o parálisis facial idiopática de la medicina occidental, la cual también es efectivamente tratada con acupuntura; sin embargo en la actualidad no hay estudios al respecto en nuestra población. El objetivo es describir las características de población, presentación y evolución de la parálisis facial asociada ...

  14. Tumour microenvironments induce expression of urokinase plasminogen activator receptor (uPAR and concomitant activation of gelatinolytic enzymes.

    Directory of Open Access Journals (Sweden)

    Synnøve Magnussen

    Full Text Available The urokinase plasminogen activator receptor (uPAR is associated with poor prognosis in oral squamous cell carcinoma (OSCC, and increased expression of uPAR is often found at the invasive tumour front. The aim of the current study was to elucidate the role of uPAR in invasion and metastasis of OSCC, and the effects of various tumour microenvironments in these processes. Furthermore, we wanted to study whether the cells' expression level of uPAR affected the activity of gelatinolytic enzymes.The Plaur gene was both overexpressed and knocked-down in the murine OSCC cell line AT84. Tongue and skin tumours were established in syngeneic mice, and cells were also studied in an ex vivo leiomyoma invasion model. Soluble factors derived from leiomyoma tissue, as well as purified extracellular matrix (ECM proteins, were assessed for their ability to affect uPAR expression, glycosylation and cleavage. Activity of gelatinolytic enzymes in the tissues were assessed by in situ zymography.We found that increased levels of uPAR did not induce tumour invasion or metastasis. However, cells expressing low endogenous levels of uPAR in vitro up-regulated uPAR expression both in tongue, skin and leiomyoma tissue. Various ECM proteins had no effect on uPAR expression, while soluble factors originating from the leiomyoma tissue increased both the expression and glycosylation of uPAR, and possibly also affected the proteolytic processing of uPAR. Tumours with high levels of uPAR, as well as cells invading leiomyoma tissue with up-regulated uPAR expression, all displayed enhanced activity of gelatinolytic enzymes.Although high levels of uPAR are not sufficient to induce invasion and metastasis, the activity of gelatinolytic enzymes was increased. Furthermore, several tumour microenvironments have the capacity to induce up-regulation of uPAR expression, and soluble factors in the tumour microenvironment may have an important role in the regulation of posttranslational

  15. Transmission and Distribution of Photosynthetically Active Radiation (PAR) for Biomass Production in Exploration Missions [7226-270], Phase II

    Data.gov (United States)

    National Aeronautics and Space Administration — Physical Sciences Inc. (PSI) proposes to develop a plant lighting system which collects, transmits and distributes photosynthetically active radiation (PAR) for...

  16. Transmission and Distribution of Photosymthetically Active Radiation (PAR) for Biomass Production in Exploration Missions [7216-050], Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — Physical Sciences Inc. (PSI) proposes to develop a plant lighting system which collects, transmits and distributes photosynthetically active radiation (PAR) for...

  17. Tumour Microenvironments Induce Expression of Urokinase Plasminogen Activator Receptor (uPAR) and Concomitant Activation of Gelatinolytic Enzymes

    Science.gov (United States)

    Magnussen, Synnøve; Hadler-Olsen, Elin; Latysheva, Nadezhda; Pirila, Emma; Steigen, Sonja E.; Hanes, Robert; Salo, Tuula; Winberg, Jan-Olof; Uhlin-Hansen, Lars; Svineng, Gunbjørg

    2014-01-01

    Background The urokinase plasminogen activator receptor (uPAR) is associated with poor prognosis in oral squamous cell carcinoma (OSCC), and increased expression of uPAR is often found at the invasive tumour front. The aim of the current study was to elucidate the role of uPAR in invasion and metastasis of OSCC, and the effects of various tumour microenvironments in these processes. Furthermore, we wanted to study whether the cells’ expression level of uPAR affected the activity of gelatinolytic enzymes. Methods The Plaur gene was both overexpressed and knocked-down in the murine OSCC cell line AT84. Tongue and skin tumours were established in syngeneic mice, and cells were also studied in an ex vivo leiomyoma invasion model. Soluble factors derived from leiomyoma tissue, as well as purified extracellular matrix (ECM) proteins, were assessed for their ability to affect uPAR expression, glycosylation and cleavage. Activity of gelatinolytic enzymes in the tissues were assessed by in situ zymography. Results We found that increased levels of uPAR did not induce tumour invasion or metastasis. However, cells expressing low endogenous levels of uPAR in vitro up-regulated uPAR expression both in tongue, skin and leiomyoma tissue. Various ECM proteins had no effect on uPAR expression, while soluble factors originating from the leiomyoma tissue increased both the expression and glycosylation of uPAR, and possibly also affected the proteolytic processing of uPAR. Tumours with high levels of uPAR, as well as cells invading leiomyoma tissue with up-regulated uPAR expression, all displayed enhanced activity of gelatinolytic enzymes. Conclusions Although high levels of uPAR are not sufficient to induce invasion and metastasis, the activity of gelatinolytic enzymes was increased. Furthermore, several tumour microenvironments have the capacity to induce up-regulation of uPAR expression, and soluble factors in the tumour microenvironment may have an important role in the

  18. Rational targeting of the urokinase receptor (uPAR): development of antagonists and non-invasive imaging probes

    DEFF Research Database (Denmark)

    Kriegbaum, M C; Persson, M; Haldager, L

    2011-01-01

    -ray crystallography and surface plasmon resonance studies. Importantly, these structural studies also define possible druggable target sites in uPAR for small molecules and provide guidelines for the development of reporter groups applicable for non-invasive molecular imaging of uPAR expression in vivo by positron...... emission tomography. In this review, we will discuss recent advances in our perception of the structure-function relationships of uPAR ligation and how these may assist translational research in preclinical intervention studies of uPAR function....

  19. A mechanism for ParB-dependent waves of ParA, a protein related to DNA segregation during cell division in prokaryotes

    DEFF Research Database (Denmark)

    Hunding, Axel; Gerdes, Kenn; Charbon, Gitte Ebersbach

    2003-01-01

    Prokaryotic plasmids encode partitioning (par) loci involved in segregation of DNA to daughter cells at cell division. A functional fusion protein consisting of Walker-type ParA ATPase and green fluorescent protein (Gfp) oscillates back and forth within nucleoid regions with a wave period of about...... in an autocatalytic process. We discuss this mechanism in relation to recent models for MinDE oscillations in E.coli and to microtubule degradation in mitosis. The study points to an ancestral role for the presented pattern types in generating bipolarity in prokaryotes and eukaryotes....... formation, based on Turing's mechanism, and these patterns are destroyed by the degradation products, only to initiate a new pattern at the opposite nucleoid region. A recurrent wave thus emerges. This may be a particular example of a more general class of pattern forming mechanisms, based on protein...

  20. Helicophyllaceae (Bryophyta, nova ocorrência para o Estado do Pará, Brasil Helicophyllaceae (Bryophyta, a new record to Pará State, Brazil

    Directory of Open Access Journals (Sweden)

    Regina C. L. Lisboa

    2005-09-01

    Full Text Available Helicophyllaceae, família monotípica neotropical, é registrada pela primeira vez no Estado do Pará. Sua única espécie, Helicophyllum torquatum (Hook. Brid., registrada anteriormente no Estado do Amazonas e que recentemente havia sido excluída da lista de musgos amazônicos, é apresentada como nova ocorrência para toda a Amazônia brasileira.Helicophyllaceae, a monotypic family of Neotropics, is presented for the Pará State. Helicophyllum torquatum (Hook. Brid., the single species, was recorded for the Amazonas State, but recently was excluded of checklist of Amazonian mosses. H. torquatum is considered a new report for all Brazilian Amazônia.

  1. Toxina botulínica y fisioterapia en la parálisis cerebral infantil

    OpenAIRE

    Camilieri Rumbau, María Mercé

    2006-01-01

    Introducción: La parálisis cerebral es la causa más común de espasticidad en niños y la toxina botulínica A es un opción para su el tratamiento, ya que produce una parálisis local al ser inyectada en un músculo. Objetivo: Comprobar la eficacia de la aplicación de toxina botulínica y fisioterapia en la parálisis cerebral infantil. Material y método: Se ha realizado una búsqueda en diversas bases de datos electrónicas como son Freejournals, Doyma, Medline, Google y revistas de neuro...

  2. Evaluation of Passive Autocatalytic Recombiner (PAR) Implementation in a Konvoi NPP Containment Type

    Energy Technology Data Exchange (ETDEWEB)

    Lopez-Alonso, E.; Papini, D.; Jimenez, G.

    2015-07-01

    The evaluation of Passive Autocatalytic Recombiner (PAR) implementation has been developed under the methodology extracted from the IAEA document, analysing the size, location and number of the PARs capable to minimize the combustion risk, which arises from a hydrogen release generated during a severe accident and its distribution in containment building. A detailed three-dimensional model of Konvoi (PWR) containment with GOTHIC 8.1 code was used for the simulations. The hydrogen preferential pathways and the accumulation points were studied and identified on the basis of a base case scenario without any mitigation measure. The PAR configuration offers an improvement in the chosen accidental scenario; decreasing the possibility of hydrogen combustion and leading to concentration values below the flammability limit (hydrogen concentration below 7%), in all the containment compartments at the end of the transient. Furthermore, from the analysis, it is concluded that the time required to reach hydrogen concentrations below the combustion limit is considerably reduced. (Author)

  3. Potential Ecological Effects of Contaminants in the Exposed Par Pond Sediments

    International Nuclear Information System (INIS)

    Paller, M.H.; Wike, L.D.

    1996-08-01

    Sediment and small mammal samples were collected from the exposed sediments of Par Pond in early 1995, shortly before the reservoir was refilled after a 4-year drawdown. Sampling was confined to elevations between 58 and 61 meters (190 and 200 feet) above mean sea level, which includes the sediments likely to be exposed if the Par Pond water level is permitted to fluctuate naturally. Both soil and small mammal samples were analyzed for a number of radionuclides and metals. Some of the soil samples were also analyzed for organic contaminants. The objective of the study was to determine if contaminant levels in the Par Pond sediments were high enough to cause deleterious ecological effects

  4. Targeting of peptide conjugated magnetic nanoparticles to urokinase plasminogen activator receptor (uPAR) expressing cells

    DEFF Research Database (Denmark)

    Hansen, Line; Larsen, Esben Kjær Unmack; Nielsen, Erik Holm

    2013-01-01

    Ultrasmall superparamagnetic iron oxide (USPIO) nanoparticles are currently being used as a magnetic resonance imaging (MRI) contrast agent in vivo, mainly by their passive accumulation in tissues of interest. However, a higher specificity can ideally be achieved when the nanoparticles are targeted...... towards cell specific receptors and this may also facilitate specific drug delivery by an enhanced target-mediated endocytosis. We report efficient peptide-mediated targeting of magnetic nanoparticles to cells expressing the urokinase plasminogen activator receptor (uPAR), a surface biomarker for poor...... patient prognosis shared by several cancers including breast, colorectal, and gastric cancers. Conjugation of a uPAR specific targeting peptide onto polyethylene glycol (PEG) coated USPIO nanoparticles by click chemistry resulted in a five times higher uptake in vitro in a uPAR positive cell line compared...

  5. Bufo & Spallanzani e a paródia pós-modernista

    Directory of Open Access Journals (Sweden)

    Saulo Brandão

    2016-02-01

    Full Text Available O presente trabalho tem por objetivo investigar as considerações acerca da paródia e sua implicação na linha teórica pós-modernista, partindo das análises de Fredric Jameson e Linda Hutcheon, quando conceituando pastiche. Desse modo, nos propomos a fazer uma análise das paródias no romance Bufo & Spallanzani, de Rubem Fonseca, a partir da leitura de Ana Cristina T. de B. Carvalho (2013 que corrobora para sonegar a proposta de Jameson. Desse modo, procuraremos, no emaranhado de citações do romance, que remetem aos mais diversos campos da cultura, elementos que qualifiquem a característica paródica do romance, tendo por embasamento a contraproposta feita por Linda Hutcheon.

  6. Excrétion de carbone organique par le phytoplancton lémanique

    OpenAIRE

    Feuillade, M.; Dufour, Philippe; Feuillade, J.; Pelletier, J.P.

    1986-01-01

    L'excrétion du carbone organique dissous par le phytoplancton du lac Léman a été évaluée par la méthode du 14C entre mars et novembre 1984. Elle varie entre 0,01 et 0,5 mgC.m-3.h-1 et dépend en premier lieu de la vitesse d'assimilation photosynthétique. L'excrétion carbonée oscille généralement entre 2 et 5% de l'assimilation carbonée et n'excède qu'exceptionnellement 6%. Les valeurs sont sous-estimées par la réassimilation hétérotrophe. L'excrétion nocturne représente moins de 10% des pertes...

  7. Potential Ecological Effects of Contaminants in the Exposed Par Pond Sediments

    Energy Technology Data Exchange (ETDEWEB)

    Paller, M.H. [Westinghouse Savannah River Company, AIKEN, SC (United States); Wike, L.D.

    1996-08-01

    Sediment and small mammal samples were collected from the exposed sediments of Par Pond in early 1995, shortly before the reservoir was refilled after a 4-year drawdown. Sampling was confined to elevations between 58 and 61 meters (190 and 200 feet) above mean sea level, which includes the sediments likely to be exposed if the Par Pond water level is permitted to fluctuate naturally. Both soil and small mammal samples were analyzed for a number of radionuclides and metals. Some of the soil samples were also analyzed for organic contaminants. The objective of the study was to determine if contaminant levels in the Par Pond sediments were high enough to cause deleterious ecological effects.

  8. Accouchement par césarienne et mortalité maternelle du postpartum

    OpenAIRE

    Deneux-Tharaux , Catherine; Carmona , Elodie; Bouvier-Colle , Marie-Hélène; Bréart , Gérard

    2006-01-01

    Objectifs Une augmentation continue du taux d'accouchements par césarienne (CS)est observée dans la plupart des pays depuis 20 ans. Cette évolution a suscité l'émergence d'un débat controversé sur les risques et les bénéfices associés à la CS. L'objectif de cette étude était d'estimer le risque de mort maternelle du postpartum lié directement à la CS par comparaison à l'accouchement par voie basse, globalement et en distinguant les CS pre- ou intra- partum . Méthode Etude cas/témoins. Les cas...

  9. Harmonization and development of resources and tools for Italian natural language processing within the PARLI project

    CERN Document Server

    Bosco, Cristina; Delmonte, Rodolfo; Moschitti, Alessandro; Simi, Maria

    2015-01-01

    The papers collected in this volume are selected as a sample of the progress in Natural Language Processing (NLP) performed within the Italian NLP community and especially attested by the PARLI project. PARLI (Portale per l’Accesso alle Risorse in Lingua Italiana) is a project partially funded by the Ministero Italiano per l’Università e la Ricerca (PRIN 2008) from 2008 to 2012 for monitoring and fostering the harmonic growth and coordination of the activities of Italian NLP. It was proposed by various teams of researchers working in Italian universities and research institutions. According to the spirit of the PARLI project, most of the resources and tools created within the project and here described are freely distributed and they did not terminate their life at the end of the project itself, hoping they could be a key factor in future development of computational linguistics.

  10. Relación entre la Deseabilidad Social y los parámetros del Modelo Logístico de tres parámetros

    Directory of Open Access Journals (Sweden)

    Facundo Abal

    2015-05-01

    Full Text Available El objetivo de este trabajo es estudiar la relación de los parámetros a , b y c del modelo logístico de tres parámetros y la tendencia de los individuos a atribuirse a sí mismo cualidades socialmente deseables. Participaron 1592 personas que respondieron las escalas Perseverancia y Distorsión del Big Five Questionnaire (BFQ. Se aplicó el ML3p a los ítems de perseverancia mediante el programa MULTILOG. Previamente se debieron eliminar 3 reactivos para cumplir con la condición de unidimensionalidad requerida por el modelo. Como la escala Likert de los ítems de perseverancia tiene 5 de alternativas se contemplaron diferentes procedimientos para establecer 4 condiciones de dicotomización de los datos. Los parámetros de los ítems se estimaron el procedimiento de Máxima Verosimilitud Marginal a Posteriori. El ajuste del ML3p fue adecuado para los 9 ítems analizados. Considerando las diferentes condiciones de dicotomización se identificaron entre 3 y 5 ítems de cuya respuesta clave se asoció a mayores niveles de Distorsión. Sin embargo, los resultados obtenidos no permiten concluir que la respuesta influida por la deseabilidad social repercuta sobre alguno de los parámetros estudiados. Se discuten las limitaciones del presente estudio y se comentan otras líneas de investigación que pueden guiar a futuros estudios.

  11. Comparison of Direct Pars Repair Techniques of Spondylolysis in Pediatric and Adolescent Patients: Pars Compression Screw Versus Pedicle Screw-Rod-Hook.

    Science.gov (United States)

    Karatas, Ali F; Dede, Ozgur; Atanda, Alfred A; Holmes, Larry; Rogers, Kenneth; Gabos, Peter; Shah, Suken A

    2016-08-01

    Retrospective clinical cohort study. To compare the clinical and radiographic outcomes of patients who were treated with intrasegmental pars fixation by either laminar compression screw (LS) or a pedicle screw, rod, and laminar hook (PSRH) construct. Spondylolysis is a nonunion defect of the pars interarticularis. In symptomatic spondylolysis, direct repair of the pars interarticularis defect can preserve motion and prevent abnormal stresses at the adjacent levels. Sixteen patients who failed nonoperative treatment and underwent direct pars repair by using LS (n=9) or PSRH (n=7) constructs were included in the study. Clinical outcome was assessed by using the MacNab criteria. Radiologic fusion and complications were evaluated using plain radiographs or computed tomography images and patient charts. The healing rate was 100% after 6 months. The healing time was similar in both the groups: LS, 6.5 months; PSRH, 6.2 months. Patients with PSRH (5.9 mo) were more likely to return to sports earlier relative to patients with LS (7.7 mo). There were no complications in the LS group; in the PSRH group, 1 patient had mild sensory deficit and 2 had superficial wound infections. The MacNab criteria for pain assessment showed an excellent or good outcome in 8 of 9 patients in LS group and 6 of 7 patients in PSRH group. Relative to LS patients, there was a significant increase in surgical time and estimated blood loss among PSRH patients. Either of the mentioned 2 techniques appears to produce acceptable results. Biplanar fluoroscopy and navigation systems could minimize the risk of screw misplacement with LS construct. Familiarity with the various fixation techniques will allow the surgeon to select the most appropriate surgical technique.

  12. First-in-human uPAR PET: Imaging of Cancer Aggressiveness

    Science.gov (United States)

    Persson, Morten; Skovgaard, Dorthe; Brandt-Larsen, Malene; Christensen, Camilla; Madsen, Jacob; Nielsen, Carsten H.; Thurison, Tine; Klausen, Thomas Levin; Holm, Søren; Loft, Annika; Berthelsen, Anne Kiil; Ploug, Michael; Pappot, Helle; Brasso, Klaus; Kroman, Niels; Højgaard, Liselotte; Kjaer, Andreas

    2015-01-01

    A first-in-human clinical trial with Positron Emission Tomography (PET) imaging of the urokinase-type plasminogen activator receptor (uPAR) in patients with breast, prostate and bladder cancer, is described. uPAR is expressed in many types of human cancers and the expression is predictive of invasion, metastasis and indicates poor prognosis. uPAR PET imaging therefore holds promise to be a new and innovative method for improved cancer diagnosis, staging and individual risk stratification. The uPAR specific peptide AE105 was conjugated to the macrocyclic chelator DOTA and labeled with 64Cu for targeted molecular imaging with PET. The safety, pharmacokinetic, biodistribution profile and radiation dosimetry after a single intravenous dose of 64Cu-DOTA-AE105 were assessed by serial PET and computed tomography (CT) in 4 prostate, 3 breast and 3 bladder cancer patients. Safety assessment with laboratory blood screening tests was performed before and after PET ligand injection. In a subgroup of the patients, the in vivo stability of our targeted PET ligand was determined in collected blood and urine. No adverse or clinically detectable side effects in any of the 10 patients were found. The ligand exhibited good in vivo stability and fast clearance from plasma and tissue compartments by renal excretion. In addition, high uptake in both primary tumor lesions and lymph node metastases was seen and paralleled high uPAR expression in excised tumor tissue. Overall, this first-in-human study therefore provides promising evidence for safe use of 64Cu-DOTA-AE105 for uPAR PET imaging in cancer patients. PMID:26516369

  13. Suppression of Arterial Thrombosis without Affecting Hemostatic Parameters with A Cell-Penetrating PAR1 Pepducin

    Science.gov (United States)

    Zhang, Ping; Gruber, András; Kasuda, Shogo; Kimmelstiel, Carey; O’Callaghan, Katie; Cox, Daniel H.; Bohm, Andrew; Baleja, James D.; Covic, Lidija; Kuliopulos, Athan

    2012-01-01

    Background Thrombin-dependent platelet activation is heightened in the setting of percutaneous coronary intervention (PCI) and may cause arterial thrombosis with consequent myocardial necrosis. Given the high incidence of adverse effects in patients with acute coronary syndromes (ACS), there remains an unmet need for the development of new therapeutics that target platelet activation without unduly affecting hemostasis. The thrombin receptor, PAR1, has recently emerged as a promising new target for therapeutic intervention in ACS patients. Methods and Results We report the development of a first-in-class intracellular PAR1 inhibitor with optimized pharmacokinetic properties for use during PCI in ACS patients. PZ-128 is a cell-penetrating ‘pepducin’ inhibitor of PAR1 which targets the receptor-G protein interface on the inside surface of platelets. The structure of PZ-128 closely resembles the predicted off-state of the corresponding juxtamembrane region of the third intracellular loop of PAR1. The onset of action of PZ-128 was rapid and suppressed PAR1 aggregation and arterial thrombosis in guinea pigs and baboons and strongly synergized with oral clopidogrel. There was full recovery of platelet function by 24 h. Importantly, PZ-128 had no effect on bleeding or coagulation parameters in primates or in blood from PCI patients. Conclusions Based on the efficacy data in non-human primates with no noted adverse effects on hemostasis, we anticipate that the rapid onset of platelet inhibition and reversible properties of PZ-128 are well suited to the acute interventional setting of PCI and may provide an alternative to long-acting small molecule inhibitors of PAR1. PMID:22705889

  14. Protease activated receptors (PARS) mediation in gyroxin biological activity; Mediacao dos receptores ativados por proteases (PARs) em atividades biologicas da giroxina

    Energy Technology Data Exchange (ETDEWEB)

    Silva, Jose Alberto Alves da

    2009-07-01

    Gyroxin is a serine protease enzyme from the South American rattlesnake (Crotalus durissus terrificus) venom; it is only partially characterized and has multiple activities. Gyroxin induces blood coagulation, blood pressure decrease and a neurotoxic behavior named barrel rotation. The mechanisms involved in this neurotoxic activity are not known. Whereas gyroxin is a member of enzymes with high potential to become a new drug with clinical applications such as thrombin, batroxobin, ancrod, tripsyn and kalicrein, it is important to find out how gyroxin works. The analysis on agarose gel electrophoresis and circular dichroism confirmed the molecules' integrity and purity. The gyroxin intravenous administration in mice proved its neurotoxicity (barrel rotation). In vivo studies employing intravital microscopy proved that gyroxin induces vasodilation with the participation of protease activated receptors (PARs), nitric oxide and Na+K+ATPase. The leukocytes' adherence and rolling counting indicated that gyroxin has no pro inflammatory activity. Gyroxin induced platelet aggregation, which was blocked by inhibitors of PAR1 and PAR4 receptors (SCH 79797 and tcY-NH{sub 2}, respectively). Finally, it was proved that the gyroxin temporarily alter the permeability of the blood brain barrier (BBB). Our study has shown that both the protease-activated receptors and nitric oxide are mediators involved in the biological activities of gyroxin. (author)

  15. Projekts Parādu piedziņas kompānijas SIA "Parāds" dibināšana

    OpenAIRE

    Poļakovs, Deniss

    2011-01-01

    Pašlaik Latvijas Republikas ekonomika ir uz atgūšanas ceļa, taču, krīzes laikā, izsniegto kredītu apjomi un pakalpojumi ar pēcapmaksu, ir kļuvuši par apgrūtinājumu daudziem uzņēmumiem un fiziskam personām, līdz ar to, arvien aktuālāks kļūst jautājums par parādu atgūšanu. Tas rada situāciju, kad uzņēmumam ir jāpieņem lēmums, vai šīs lietas uzņemties pašam, vai uzticēt piedziņu profesionālām kompānijām, kas ar to nodarbojas. Pacta sunt servanda!" jeb "Līgumi jāpilda!" – tā formulēts viens no...

  16. Nanostructures originales obtenues par décomposition catalytique d'hydrocarbure

    OpenAIRE

    Amamra , M.C.; Lihrmann , J.-M.; Thorel , Alain

    2010-01-01

    National audience; L'arc électrique et la décomposition catalytique d'hydrocarbures peuvent produire diverses nanostructures de carbone, telles que fullerènes, nanotubes, nanofibres et autres particules nanométriques de carbone. Une publication récente1 décrit la préparation et la séparation de nanobâtonnets de carbone dans la suie produite par arc électrique. Ici nous présentons la fabrication de nanobâtonnets de carbone par décomposition catalytique d'hydrocarbures, ainsi que des fibrilles ...

  17. Essai de discrimination du tissu urbain par segmentation d'image

    Directory of Open Access Journals (Sweden)

    Bénédicte COLLETTE

    1991-12-01

    Full Text Available La segmentation est une technique qui, appliquée à l’imagerie satellitaire, permet une détermination zonale des affectations, plutôt que la traditionnelle classification pixel par pixel. Cette détermination zonale correspond davantage aux informations utiles, en urbanisme par exemple. C’est dans cette optique que la méthodologie a été appliquée à l’image d’Aix-la-Chapelle (Aachen, pour y discerner différents types d’urbanisation, selon la densité ou la période d’édification.

  18. Calidad y parálisis del sueño en estudiantes de medicina

    OpenAIRE

    Huamaní, Charles; Reyes, Arturo; Mayta-Tristán, Percy; Timana, Raúl; Salazar, Abel; Sánchez, David; Pérez, Hugo

    2013-01-01

    Introducción: La parálisis del sueño es un evento de inmovilización corporal estando consciente, ocurre espontáneamente o secundaria a situaciones estresantes o una posible mala calidad de sueño. Objetivo: Determinar la asociación y riesgo de tener parálisis del sueño en los estudiantes de la facultad de medicina, que son malos dormidores. Diseño: Estudio analítico, transversal. Lugar: Facultad de Medicina de la Universidad Nacional Mayor de San Marcos. Participantes: Estudiantes de medicina....

  19. Calidad y parálisis del sueño en estudiantes de medicina

    OpenAIRE

    Charles Huamaní; Arturo Reyes; Percy Mayta-Tristán; Raúl Timana; Abel Salazar; David Sánchez; Hugo Pérez

    2006-01-01

    Introducción: La parálisis del sueño es un evento de inmovilización corporal estando consciente, ocurre espontáneamente o secundaria a situaciones estresantes o una posible mala calidad de sueño. Objetivo: Determinar la asociación y riesgo de tener parálisis del sueño en los estudiantes de la facultad de medicina, que son malos dormidores. Diseño: Estudio analítico, transversal. Lugar: Facultad de Medicina de la Universidad Nacional Mayor de San Marcos. Participantes: Estudiantes de medicina....

  20. Calidad y parálisis del sueño en estudiantes de medicina

    Directory of Open Access Journals (Sweden)

    Charles Huamaní

    2006-10-01

    Full Text Available Introducción: La parálisis del sueño es un evento de inmovilización corporal estando consciente, ocurre espontáneamente o secundaria a situaciones estresantes o una posible mala calidad de sueño. Objetivo: Determinar la asociación y riesgo de tener parálisis del sueño en los estudiantes de la facultad de medicina, que son malos dormidores. Diseño: Estudio analítico, transversal. Lugar: Facultad de Medicina de la Universidad Nacional Mayor de San Marcos. Participantes: Estudiantes de medicina. Intervenciones: En mayo de 2006, se realizó una muestra no probabilística de estudiantes, por medio de una encuesta que incluía el índice de calidad de sueño de Pittsburg y preguntas sobre parálisis del sueño. Se determinó la asociación entre las variables parálisis del sueño y calidad del sueño y el riesgo (OR de parálisis del sueño en malos dormidores. Se empleó las pruebas de chi cuadrado para las variables cualitativas y t de student para las cuantitativas, con un 95% de confiabilidad. Principales medidas de resultados: Experiencias de parálisis del sueño y prevalencia de malos dormidores. Resultados: El promedio de edad fue 22,3+2,7 años; el 55,5% fue mujer. Las experiencias de parálisis del sueño informadas durante el último mes ocurrieron en 26,6% (21,6 a 32,1% y la prevalencia de malos dormidores fue 48,5% (42,6 a 54,3%. No existió asociación entre ellas (x 2 , p = 0,1; OR = 1,54; IC95: 0,9 a 2,6. Conclusiones: No se halla asociación entre la presentación de parálisis del sueño y una mala calidad de sueño, difiriendo ello con diversos estudios previos, por lo que se sugiere indagar sobre otros factores que pudiesen desencadenarla.

  1. evaluation de la fertilite femelle des arabusta par le niveau de ...

    African Journals Online (AJOL)

    Les hybrides Arabusta sont caractérisés par une faible fertilité exprimée par des taux de caracolis élevés et des taux de loges vides importants induisant des productivités faibles. Pour une stratégie plus efficiente des sélections, il est important de connaître les niveaux de fertilité femelle des différents types de caféiers ...

  2. Parásitos de Fasciola hepática intracoledociano

    OpenAIRE

    MILLÁN A,MARCELO; WAGENKNECHT S,RAUL; CARDENAS P,ALEX; CARRASCO L,CRISTIAN

    2008-01-01

    La fasciolasis es una enfermedad parasitaria producida por el tremátodo digeneo Fasciola hepática. Durante la fase crónica de la enfermedad los parásitos pueden entran en los conductos biliares, y ser causa de ictericia obstructiva, colangitis, pancreatitis y otras complicaciones. Se presenta el caso clínico de una paciente intervenida por sospecha de colelitiasis y colédocolitiasis, a la cual durante la exploración coledociana intraoperatoria le fueron extraídos múltiples parásitos adultos d...

  3. Optimización de una cadena de suministros hospitalarios incorporando parámetros difusos

    OpenAIRE

    Kees, María Celeste; Cragno, María Constanza; Moreno, Marta Susana; Bandoni, Alberto

    2016-01-01

    El propósito de este trabajo es determinar la estructura óptima de una cadena de suministro de insumos hospitalarios. Para ello se plantea un modelo mixto entero lineal determinístico cuyos objetivos de optimización son tanto la minimización de los costos generales como la minimización de los tiempos de envío. Debido a la presencia de incertidumbre en algunos parámetros del problema, se presenta una segunda formulación multiobjetivo en la que se incorporan parámetros difusos a través de una m...

  4. Nature des dommages causés par les piqûres alimentaires des ...

    African Journals Online (AJOL)

    Ces piqûres ont provoqué des nécroses sur les pétales et les étamines qui ont été totalement ou partiellement détruites. Ces dommages ont développé sur les boutons floraux le phénomène d'abscission. Par contre, sur les jeunes capsules infestées, les résultats ont montré que les dégâts causés par H. schoutedeni ont été ...

  5. Neuropathie optique bilatérale par intoxication aigue au méthanol ...

    African Journals Online (AJOL)

    La consommation d'alcool frelaté, contenant du méthanol, est un phénomène de société au Cameroun. Nous rapportons deux cas d'intoxication cécitante au méthanol dont l'évolution a été marquée pour l'un par l'installation d'une cécité irréversible et pour l'autre par une récupération partielle de l'acuité visuelle. Ces cas ...

  6. Prise en charge des péritonites par perforation d'ulcères gastro ...

    African Journals Online (AJOL)

    Le but de cette étude a été de décrire la prise en charge des péritonites aiguës généralisées par perforation d'ulcère gastrique ou duodénal et d'évaluer le bénéfice du drainage abdominal. Nous avons réalisé une étude transversale sur 3 ans. Elle a inclus 129 patients opérés pour péritonites par perforation gastrique ou ...

  7. Flora das cangas da Serra dos Carajás, Pará, Brasil: Caryocaraceae

    OpenAIRE

    Nunes, Clebiana de Sá; Gil, André dos Santos Bragança

    2016-01-01

    Resumo Foi encontrada uma única espécie de Caryocaraceae nas cangas da Serra dos Carajás, Pará, Brasil: Caryocar villosum. É fornecida uma descrição morfológica, prancha ilustrativa, além de comentários taxonômicos, distribuição geográfica e habitat da espécie. Abstract Only one species of Caryocaraceae was found in the canga formations of the Serra dos Carajás, Pará state, Brazil: Caryocar villosum. A morphological description, illustration, geographical distribution and habitat of this s...

  8. Densité, morphologie urbaine et qualité de vie. Une approche par le projet

    OpenAIRE

    Occhiuto, Rita; Goossens, Marc; Fisher, Axel

    2013-01-01

    La recherche "Densification des tissus urbanisés en Wallonie: forme, acceptabilité et modalités pour accompagner la mutation des tissus bâtis" s'articule en plusieurs volets thématiques, parmi lesquels figure le volet "formes urbaines, modes d'habitat". Ce dernier volet est abordé selon deux approches parallèles et complémentaires qui se valident mutuellement: la première dite "par le projet" (approche qualitative et opérationnelle) et la seconde par analyse statistique et cartographique (ap...

  9. Flora das cangas da Serra dos Carajás, Pará, Brasil: Sapotaceae

    OpenAIRE

    Terra-Araujo, Mário Henrique; Zappi, Daniela Cristina

    2018-01-01

    Resumo Uma única espécie de Sapotaceae, Chrysophylloideae, Pouteria ramiflora, ocorre sobre canga na Serra dos Carajás, estado do Pará, Brasil. Este trabalho apresentada uma descrição detalhada, fotografias e comentários morfológicos sobre esta espécie. Abstract A single species of Sapotaceae, Chrysophylloideae, Pouteria ramiflora, occurs on iron-stone (canga) at the Serra dos Carajás, Pará, Brazil. This paper presents a detailed description, photographs and comments regarding this species...

  10. Equações de chuvas intensas para o estado do Pará Intense rainfall equations for the state of Pará, Brazil

    Directory of Open Access Journals (Sweden)

    Rodrigo O. R. de M. Souza

    2012-09-01

    Full Text Available As equações de chuvas intensas têm sido usadas como ferramenta importante para o dimensionamento de obras hidráulicas. Devido à grande carência de informações relativas às equações de chuvas intensas, o presente trabalho teve como objetivo a obtenção das relações de intensidade, duração e frequência de precipitação pluvial para o Estado do Pará, utilizando-se a metodologia da desagregação da chuva de 24 h. Foram utilizadas séries históricas de dados pluviométricos de 74 cidades do Estado do Pará, obtidas no Sistema de Informações Hidrológicas da Agência Nacional de Águas-ANA. As equações de intensidade-duração-frequência foram devidamente ajustadas e apresentaram bom ajuste, com coeficientes de determinação acima de 0,99. A maioria das estações (51,4% apresentou intensidade de precipitação entre 90 e 110 mm h-1, para uma duração de chuva de 30 min e um tempo de retorno de 15 anos. Pode-se perceber uma concentração das maiores precipitações na região próxima ao litoral do nordeste paraense e no sudeste da Ilha do Marajó.The intense rainfall equations have been used as an important tool for design of hydraulic structures. Considering the lack of intense rainfall equations, this study aimed to determine the relations of intensity, duration and frequency of intense rainfall in the Pará State (Brazil, using the one-day rain disaggregation method. In this research rainfall data of 74 cities in the State of Pará were used, obtained from the Hydrological Information System of the National Water Agency-ANA. The equations of intensity-duration-frequency were adjusted and presented good adjustment with coefficients of determination above 0.99. Most stations (51.4% showed intensity of precipitation between 90 and 110 mm h-1 for duration of 30 min and rainfall return period of 15 years. The highest rainfall intensities were in the region near the northeast coast of Pará State and southeast of the Marajo

  11. Experimental study about the regulating effect of Par-4 gene overexpression on the nephroblastoma sensitivity to cisplatin

    Directory of Open Access Journals (Sweden)

    Hui-Lin Mao

    2017-11-01

    Full Text Available Objective: To study the regulating effect of Par-4 gene overexpression on the nephroblastoma sensitivity to cisplatin. Methods: Nephroblastoma SK-NEP-1 cells were cultured and divided into four groups, control group were treated with RMPI-1640 without serum or drugs, cisplatin group were treated with serum-free RMPI-1640 containing 5 μg/mL cisplatin, Par-4 group were transfected by Par-4 overexpression plasmids with serum-free RMPI-1640, and cisplatin + Par-4 group were transfected by Par-4 overexpression plasmid with serum-free RMPI-1640 containing 5 μg/mL cisplatin. The cell proliferation activity as well the expression of apoptosis genes, migration genes and invasion genes was measured. Results: 8 h, 16 h and 24 h after different conditions of treatment, the cell proliferation activity of cisplatin group, Par-4 group and cisplatin + Par-4 group were significantly lower than that of control group, and the cell proliferation activity of cisplatin + Par-4 group was significantly lower than that of cisplatin group and Par-4 group; 24 h after different conditions of treatment, Bim, PDCD4, WT1, RGS4, Axin, KAI1, E-cadherin, PPARγ and PTEN mRNA expression in cisplatin group, Par-4 group and cisplatin + Par-4 group were greatly higher than those in control group whereas GDNF, GFRα1, TUBB3, NME1 and FGF1 mRNA expression were greatly lower than those in control group; Bim, PDCD4, WT1, RGS4, Axin, KAI1, E-cadherin, PPARγ and PTEN mRNA expression in cisplatin + Par-4 group were greatly higher than those in cisplatin group and Par-4 group whereas GDNF, GFRα1, TUBB3, NME1 and FGF1 mRNA expression were greatly significantly lower than those in cisplatin group and Par-4 group. Conclusion: Par-4 gene overexpression can increase the nephroblastoma sensitivity to cisplatin, reduce cell proliferation activity, promote apoptosis and inhibit cell migration and invasion.

  12. Planar Cell Polarity Breaks the Symmetry of PAR Protein Distribution prior to Mitosis in Drosophila Sensory Organ Precursor Cells.

    Science.gov (United States)

    Besson, Charlotte; Bernard, Fred; Corson, Francis; Rouault, Hervé; Reynaud, Elodie; Keder, Alyona; Mazouni, Khalil; Schweisguth, François

    2015-04-20

    During development, cell-fate diversity can result from the unequal segregation of fate determinants at mitosis. Polarization of the mother cell is essential for asymmetric cell division (ACD). It often involves the formation of a cortical domain containing the PAR complex proteins Par3, Par6, and atypical protein kinase C (aPKC). In the fly notum, sensory organ precursor cells (SOPs) divide asymmetrically within the plane of the epithelium and along the body axis to generate two distinct cells. Fate asymmetry depends on the asymmetric localization of the PAR complex. In the absence of planar cell polarity (PCP), SOPs divide with a random planar orientation but still asymmetrically, showing that PCP is dispensable for PAR asymmetry at mitosis. To study when and how the PAR complex localizes asymmetrically, we have used a quantitative imaging approach to measure the planar polarization of the proteins Bazooka (Baz, fly Par3), Par6, and aPKC in living pupae. By using imaging of functional GFP-tagged proteins with image processing and computational modeling, we find that Baz, Par6, and aPKC become planar polarized prior to mitosis in a manner independent of the AuroraA kinase and that PCP is required for the planar polarization of Baz, Par6, and aPKC during interphase. This indicates that a "mitosis rescue" mechanism establishes asymmetry at mitosis in PCP mutants. This study therefore identifies PCP as the initial symmetry-breaking signal for the planar polarization of PAR proteins in asymmetrically dividing SOPs. Copyright © 2015 Elsevier Ltd. All rights reserved.

  13. écrivain-e. Par-delà le genre – par-delà le corps ?

    Directory of Open Access Journals (Sweden)

    Cécile Chamayou-Kuhn

    2009-12-01

    Full Text Available Cet article propose d’étudier la relation qu’entretiennent, d’une part, le langage et le corps et, d’autre part, la parole et l’identité sexuelle dans Die Kränkung d’Evelyn Schlag et Der Tod und das Mädchen : III (Rosamunde ; V (Die Wand d’Elfriede Jelinek. Malgré les divergences de ton que présentent ces oeuvres, qui appartiennent à deux genres littéraires différents, il semble permis de centrer l’analyse sur une problématique commune : le personnage de « l’écrivain-e » parvient-il à saisir son propre corps ? Dans cette perspective, nous nous appuyons sur la critique formulée par Judith Butler à l’égard de la psychanalyse lacanienne, tout en considérant sa théorie sur la construction discursive du corps. Trois thématiques peuvent être développées : la dialectique de « l’in-visibilité » féminine, les processus de matérialisation du corps et la pratique subversive de la mascarade en tant qu’elle met en évidence certains mécanismes d’aliénation dans le cadre d’une genèse du corps et de l’écriture. Aussi peut-on affirmer que le drame du corps investi symboliquement sous-tend ces œuvres : l’écrivain-e tente de s’extraire de l’ordre symbolique et de saper les fondements des catégories constitutives de l’identité que sont le désir, le sexe biologique (sex et l’identité sexuelle (gender. Si les processus d’écriture laissent envisager un dépassement de l’offense narcissique et de la maladie dans Die Kränkung, un tel dénouement paraît exclu dans l’univers jelinekien : ses « héroïnes », qui évoluent comme autant de fantômes du signifiant, entament une éternelle danse de mort.Untersucht wird im folgenden Artikel – anhand der Texte Die Kränkung von Evelyn Schlag und Der Tod und das Mädchen III (Rosamunde und V (Die Wand von Elfriede Jelinek – das Verhältnis von Sprache zum Körper sowie die Beziehung zwischen Sprechen und

  14. Filtrage Lineaire par Morceaux Avec Petit Bruit d’Observation (Piecewise Linear Filtering with Small Observation Noise)

    Science.gov (United States)

    1990-11-19

    L’UNIXJERSITt DE PRO VENCE Sp~cialit6: MATHEMATIQUES APPLIQUPES pill Marie-Christine ROUBAUD Sujet de la fljese FILTRAGE LINEAIRE PAR MORCEAUX AVEC PETIT BRUIT...paa CENTRE ST-CHARLES pour obtenir le titre de DOCTEUR DE L’UNIVERSITE DE PRO VENCE MATHEMATIQUES APPLIQUEES par Marie-Christine ROUBAUD Sujet de la th

  15. Plasma levels of intact and cleaved urokinase plasminogen activator receptor (uPAR) in men with clinically localised prostate cancer

    DEFF Research Database (Denmark)

    Kristensen, Gitte; Berg, Kasper Drimer; Lippert, Solvej

    2017-01-01

    1 disease. Soluble uPAR forms were measured using three time-resolved fluorescence immunoassays. The prognostic value of the different uPAR forms together with clinicopathological parameters for N1 disease were analysed using logistic regression, receiver operating characteristic (ROC) regression...

  16. ‘Focus on the Learner’ in Teacher Education : PAR as a Strategy to Enable Student Voice in Schools

    NARCIS (Netherlands)

    Smit, B.H.J.; Admiraal, W.F.; Berry, A.K.

    2017-01-01

    The current presentation addresses characteristics of the TE program, PSTs learning outcomes, and enabling and constraining factors in the development and enactment of PAR. Research questions:What are the characteristics of a TE program aimed at preparing PSTs for conducting PAR with school

  17. Contamination des eaux souterraines par le lixiviat des décharges ...

    African Journals Online (AJOL)

    La percolation du lixiviat en provenance des dechets des decharges constitue une source de pollution des ressources en eau souterraine par infiltration, constituant ainsi une menace aussi importante que celle liee a l'accentuation du deficit hydrique. La decharge publique de Larache constitue un modele type de ...

  18. Funding Research Through the Online Partnership to Accelerate Research (OnPAR

    Directory of Open Access Journals (Sweden)

    Martin A. Dueñas, MPA

    2016-10-01

    Full Text Available OnPAR—the Online Partnership to Accelerate Research—seeks to provide a second opportunity for funding of high-quality, unfunded applications originally submitted to the National Institutes of Health and other national and international funding agencies. OnPAR will match applicable, unfunded applications with the research priorities of nongovernment organizations such as private biomedical foundations, pharmaceutical companies, venture capital funds, and other private funds. Funding organization members will review and make final funding decisions through a simple, 2-step process whereby applicants can submit public abstracts directly to OnPAR. If a member requests additional information, then, by invitation only, an applicant can submit their original unfunded application and their peer review summary statement. Advancing research discovery and drug development to improve clinical outcomes for patients afflicted with or at risk for disease is the primary goal of OnPAR. OnPAR invites the scientific community to fully participate in this new funding paradigm by submitting their National Institutes of Health public abstracts so that funding members can review and potentially support these high-quality, unfunded applications.

  19. Accroissement de l'autonomisation économique des femmes par l ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Par ailleurs, on observe également des écarts importants au sein même de la population féminine : les femmes pauvres et sans formation occupent un emploi rémunéré dans une proportion moindre que les autres ... Six world-class research teams to investigate overcoming therapeutic resistance in high fatality cancers.

  20. Accroissement de l'autonomisation économique des femmes par l ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    ... des sexes sur le marché du travail et d'offrir de meilleures possibilités économiques aux femmes. La direction du projet sera assurée par le Centro Interdisciplinario de Estudios sobre el Desarrollo, en Uruguay, en collaboration avec le Centro de Estudios Distributivos Laborales y Sociales de l'Universidad Nacional de La ...

  1. La fabrication de l'"Autre" par le pouvoir : Entretien avec Christine Delphy

    OpenAIRE

    Delphy, Christine; Bertaux, Daniel; Delcroix, Catherine; Pfefferkorn, Roland

    2011-01-01

    International audience; Il s'agit d'un entretien mené avec Christine Delphy sur le thème "précarités, racismes et résistances"Propos recueillis par Daniel Bertaux et Catherine Delcroix et Roland Pfefferkorn.

  2. Préparation des charbons actifs par voie chimique à l'acide ...

    African Journals Online (AJOL)

    Les matieres ligno-cellulosiques sont des precurseurs du charbon actif. Le present travail a eu pour but la preparation de charbons actifs a partir des coques de noix de coco par activation chimique a lfacide phosphorique. Pour optimiser le procede de la preparation, les effets des concentrations de lfacide phosphorique ...

  3. Elimination du cadmium de l'acide phosphorique par électrodialyse ...

    African Journals Online (AJOL)

    homme; elle est devenue un enjeu économique et politique majeur pour le développement durable des pays. L'acide phosphorique est classé en second lieu dans la production mondiale des acides après l'acide sulfurique. Il est fabriqué par ...

  4. Parásitos de animales silvestres en cautiverio en Lima, Perú

    Directory of Open Access Journals (Sweden)

    Lily Arrojo

    2013-06-01

    Full Text Available Los parásitos de los animales silvestres en cautiverio peruanos se registran aquí. La mayoría de las especies son nematodos. Dos especies son al patógeno de host: Prosthenorchois elegans y Strongyloides sp.

  5. Que sont devenues les plantes autrefois consommées par les divers ...

    African Journals Online (AJOL)

    Que sont devenues les plantes autrefois consommées par les divers groupes ethnoculturels du Togo? S Akpavi, AY Woegan, M Dourma, K Tozo, K Batawila, K Wala, KA Gbogbo, M Kanda, K Kossi-Titrikou, B de Foucault, I Butare, K Akpagana ...

  6. Représentations du lexique par les formateurs et les enseignants en ...

    African Journals Online (AJOL)

    Cependant, l'enquête par questionnaire a été retenue car elle est moins exigeante en terme de temps et de logistique. Dix écoles publiques et privées de Dar es salaam (Zanaki, Kisutu, Makongo,Kibasila, Azania, Academic International school, Aghakhan Secondary School, Loyola, Tusiime, Heritage Secondary school) ...

  7. Synthèse optimale de prise de terre par la structure du sol selon la ...

    African Journals Online (AJOL)

    Synthèse optimale de prise de terre par la structure du sol selon la méthode des elements finis. S Houndedako, C Martinez, K Bedja, JM Kauffmann. Abstract. No Abstract Available Journal des Sciences pour l\\'Ingenieur Vol 5 2005: 27-33. Full Text: EMAIL FULL TEXT EMAIL FULL TEXT · DOWNLOAD FULL TEXT ...

  8. Tuberculosis prevalence and risk factors for water buffalo in Pará, Brazil.

    Science.gov (United States)

    Barbosa, José D; da Silva, Jenevaldo B; Rangel, Charles P; da Fonseca, Adivaldo H; Silva, Natália S; Bomjardim, Henrique A; Freitas, Nayra F Q R

    2014-03-01

    The prevalence of and possible risk factors for tuberculosis were studied in water buffalo from Pará, Brazil. In this study, 3,917 pregnant and nonpregnant female Murrah and Mediterranean buffaloes were studied; 2,089 originated from Marajó Island, and 1,108 were from the mainland. The comparative cervical tuberculin test was used as a diagnostic test for tuberculosis in these animals. The prevalence of positive buffaloes was 3.5 % (100/2,809) on Marajó Island and 7.2 % (80/1,108) on the mainland. The municipalities with the highest tuberculosis prevalence rates in animals were Ipixuna do Pará (10.1 %), Marapanim (9.8 %), Chaves (9.4 %), Paragominas (8.6 %), and Cachoeira do Arari (6.7 %). The tuberculosis prevalence was not significantly different between the Murrah (4.3 %) and Mediterranean (4.8 %) breeds or between pregnant (5 %) and nonpregnant (4.3 %) buffaloes. Tuberculosis was detected in water buffaloes from Pará, Brazil; the mainland buffalo exhibited the highest tuberculosis prevalence. These results indicate that this disease is dangerous to public health and buffalo farming in Pará.

  9. Une occlusion intestinale aiguë par un os de poulet | Mahmoudi ...

    African Journals Online (AJOL)

    L'ingestion de corps étranger (CE) peut causer de multiples complications parfois graves. Il s'agit le plus souvent d'un accident survenant chez des enfants, parfois chez des malades psychiatriques. Chez les adultes, l'accident est favorisé par des mauvaises habitudes alimentaires (repas trop rapide, quintes de toux ou ...

  10. SuPAR Predicts Cardiovascular Events and Mortality in Patients With Asymptomatic Aortic Stenosis

    DEFF Research Database (Denmark)

    Hodges, Gethin W.; Bang, Casper N; Eugen-Olsen, Jesper

    2016-01-01

    valve events (AVEs), cardiovascular and all-cause mortality after adjusting for traditional cardiovascular risk factors, and allocation to treatment. Results The multivariate adjusted hazard ratio (HR) (95% confidence interval [CI]) per unit log2 ng/mL increase in suPAR was HR, 1.5; 95% CI, 1.2-1.9; P...

  11. Dual Role of Host Par2 in a Murine Model of Spontaneous Metastatic B16 Melanoma

    Czech Academy of Sciences Publication Activity Database

    Olejár, Tomáš; Větvička, D.; Zadinová, M.; Poučková, P.; Kukal, J.; Ježek, Petr; Matěj, R.

    2014-01-01

    Roč. 34, č. 7 (2014), s. 3511-3515 ISSN 0250-7005 R&D Projects: GA ČR(CZ) GAP302/10/0346 Institutional support: RVO:67985823 Keywords : PAR2 * melanoma * metastasis * murine model Subject RIV: EA - Cell Biology Impact factor: 1.826, year: 2014

  12. Ambroise Paré (1510-1590)--Traek af kirurgfagets historie og dets medi- kamentelle aspekter

    DEFF Research Database (Denmark)

    Norn, Svend; Permin, Henrik; Kruse, Poul R

    2010-01-01

    the painful practise of cautery to stop bleeding and used ligatures and dressings instead. A multitude of subjects were included in his writings such as military surgery, aneurysm, hernia, obstetrics and plague, and through his techniques he guided the development of the gentle art of surgery. Paré became...

  13. ACUTE INTRAOPERATIVE SUPRACHOROIDAL HEMORRHAGE DURING SMALL-GAUGE PARS PLANA VITRECTOMY.

    Science.gov (United States)

    Sukpen, Intira; Stewart, Jay M

    2017-11-16

    To report the intraoperative occurrence of acute intraoperative suprachoroidal hemorrhage during small-gauge pars plana vitrectomy. A review of a surgical patient who developed acute intraoperative suprachoroidal hemorrhage during small-gauge pars plana vitrectomy because of bucking under general anesthesia. A 32-year-old obese woman with proliferative diabetic retinopathy and traction retinal detachment in the left eye who developed intraoperative suprachoroidal hemorrhage during small-gauge pars plana vitrectomy because of bucking under general anesthesia while doing endolaser under air infusion. The pressure was immediately elevated to stabilize the hemorrhage without sclerotomy creation, and then gas (14% C3F8) was injected, with subsequent face-down positioning. The patient subsequently developed proliferative vitreoretinopathy, requiring additional surgery. The final visual acuity at 14-month follow-up was hand motions with a reattached retina in the left eye. Valsalva-induced suprachoroidal hemorrhage during pars plana vitrectomy under general anesthesia may result in sight-threatening visual consequences. Current small-gauge vitrectomy techniques using valved cannulas may allow for better intraoperative management of this complication through control of the intraocular pressure in a closed system.

  14. Jesus en geweld: Markus 12:1-12 (en par) en Thomas 65 | van Eck ...

    African Journals Online (AJOL)

    Jesus and violence: Mark 12:1-12 (and par) and. Thomas 65. As an advanced agrarian (aristocratic) society, first-century Palestine's social fabric was built on systemic tensions and conflicts between the elite (rulers) and the peasantry (the ruled). At the root of these conflicts were incompatible values (ideologies) and

  15. Structure and ligand interactions of the urokinase receptor (uPAR)

    DEFF Research Database (Denmark)

    Kjaergaard, Magnus; Hansen, Line V.; Jacobsen, Benedikte

    2008-01-01

    The urokinase-type plasminogen activator receptor (uPAR or CD87) is a glycolipid-anchored membrane glycoprotein, which is responsible for focalizing plasminogen activation to the cell surface through its high-affinity binding to the serine protease uPA. This tight interaction (KD less than 1 nM) ...

  16. PAR-Complex and Crumbs Function During Photoreceptor Morphogenesis and Retinal Degeneration.

    Science.gov (United States)

    Pichaud, Franck

    2018-01-01

    The fly photoreceptor has long been used as a model to study sensory neuron morphogenesis and retinal degeneration. In particular, elucidating how these cells are built continues to help further our understanding of the mechanisms of polarized cell morphogenesis, intracellular trafficking and the causes of human retinal pathologies. The conserved PAR complex, which in flies consists of Cdc42-PAR6-aPKC-Bazooka, and the transmembrane protein Crumbs (Crb) are key players during photoreceptor morphogenesis. While the PAR complex regulates polarity in many cell types, Crb function in polarity is relatively specific to epithelial cells. Together Cdc42-PAR6-aPKC-Bazooka and Crb orchestrate the differentiation of the photoreceptor apical membrane (AM) and zonula adherens (ZA) , thus allowing these cells to assemble into a neuro-epithelial lattice. In addition to its function in epithelial polarity, Crb has also been shown to protect fly photoreceptors from light-induced degeneration, a process linked to Rhodopsin expression and trafficking. Remarkably, mutations in the human Crumbs1 (CRB1) gene lead to retinal degeneration, making the fly photoreceptor a powerful disease model system.

  17. PAR-Complex and Crumbs Function During Photoreceptor Morphogenesis and Retinal Degeneration

    Directory of Open Access Journals (Sweden)

    Franck Pichaud

    2018-03-01

    Full Text Available The fly photoreceptor has long been used as a model to study sensory neuron morphogenesis and retinal degeneration. In particular, elucidating how these cells are built continues to help further our understanding of the mechanisms of polarized cell morphogenesis, intracellular trafficking and the causes of human retinal pathologies. The conserved PAR complex, which in flies consists of Cdc42-PAR6-aPKC-Bazooka, and the transmembrane protein Crumbs (Crb are key players during photoreceptor morphogenesis. While the PAR complex regulates polarity in many cell types, Crb function in polarity is relatively specific to epithelial cells. Together Cdc42-PAR6-aPKC-Bazooka and Crb orchestrate the differentiation of the photoreceptor apical membrane (AM and zonula adherens (ZA, thus allowing these cells to assemble into a neuro-epithelial lattice. In addition to its function in epithelial polarity, Crb has also been shown to protect fly photoreceptors from light-induced degeneration, a process linked to Rhodopsin expression and trafficking. Remarkably, mutations in the human Crumbs1 (CRB1 gene lead to retinal degeneration, making the fly photoreceptor a powerful disease model system.

  18. SuPAR predicts postoperative complications and mortality in patients with asymptomatic aortic stenosis

    DEFF Research Database (Denmark)

    Hodges, Gethin W; Bang, Casper N; Eugen-Olsen, Jesper

    2018-01-01

    . Methods: Baseline plasma suPAR levels were available in 411 patients who underwent AVR surgery during follow-up in the Simvastatin and Ezetimibe in Aortic Stenosis (SEAS) study. Cox analyses were used to evaluate suPAR in relation to all-cause mortality and the composite endpoint of postoperative...... complications (all-cause mortality, congestive heart failure, stroke and renal impairment) occurring in the 30-day postoperative period. Results: Patients with initially higher levels of suPAR were at increased risk of postoperative mortality with a HR of 3.5 (95% CI 1.4 to 9.0, P=0.008) and postoperative.......7 (95% CI 1.0 to 7.8, P=0.061); and postoperative complications with a HR of 2.5 (95% CI 1.3 to 5.0, P=0.007) and 2.4 (95% CI 1.2 to 4.8, P=0.011), respectively. Conclusion: Higher baseline suPAR levels are associated with an increased risk for postoperative complications and mortality in patients...

  19. Tumor MMP-1 Activates Endothelial PAR1 to Facilitate Vascular Intravasation and Metastatic Dissemination

    DEFF Research Database (Denmark)

    Juncker-Jensen, Anna; Deryugina, Elena I; Rimann, Ivo

    2013-01-01

    non-tumor-cell/non-matrix target, activation of which by carcinoma-produced MMP-1 regulates endothelial permeability and transendothelial migration. The inhibitory effects of specific PAR1 antagonists in live animals have also indicated that the mechanisms of MMP-1-dependent vascular permeability...

  20. CALiPER Report 20.3: Robustness of LED PAR38 Lamps

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2014-12-30

    A small sample of each of the CALiPER Application Summary Report 20 PAR38 lamp types underwent stress testing that included substantial temperature and humidity changes, electrical variation, and vibration. The results do not directly address expected lifetime, but can be compared with one another, as well as with benchmark conventional products, to assess the relative robustness of the product designs.

  1. La bio-indication de la pollution aquatique par les microalgues (Cas ...

    African Journals Online (AJOL)

    des Cyanophyceae au niveau de l'Oued. Bounamoussa. D'apres Collectif [13], la presence de Cyanophyceae perturbe la croissance des autres groupes d'algues, principalement les. Chlorophyceae, par competition vis-a-vis de deux elements vitaux, la lumiere et les sels mineraux, principalement le phosphore et l'azote.

  2. CRP and suPAR are differently related to anthropometry and subclinical organ damage

    DEFF Research Database (Denmark)

    Lyngbæk, Stig; Sehestedt, Thomas; Marott, Jacob L

    2013-01-01

    of the inflammation associated with CVD. METHODS: We studied 2273 subjects without CVD. Log-transformed CRP and suPAR were included in general linear and logistic regression models to compare associations with measures of anthropometry and subclinical organ damage (SOD). Owing to interactions on body mass index (BMI...

  3. PAR as a way of organising a social workers labour union in Greenland

    DEFF Research Database (Denmark)

    Andersen, John; Arnfjord, Steven

    Abstract, ALARA2015012:PAR as a way of organising a social workers labour union in Greenland for consideration and inclusion in the programme for the ALARA 9th Action Learning Action Research and 13th Participatory Action Research World Congress to be held at St. George Hotel and Conference Centre...

  4. Par@Graph - a parallel toolbox for the construction and analysis of large complex climate networks

    NARCIS (Netherlands)

    Tantet, A.J.J.

    2015-01-01

    In this paper, we present Par@Graph, a software toolbox to reconstruct and analyze complex climate networks having a large number of nodes (up to at least 106) and edges (up to at least 1012). The key innovation is an efficient set of parallel software tools designed to leverage the inherited hybrid

  5. Determining fPAR and leaf area index of several land cover classes ...

    African Journals Online (AJOL)

    ... fraction of photosynthetically active radiation (fPAR), are three fundamental biophysical characteristics of the plant canopy that should parameterise ecophysiological models of water use (evapotranspiration) and carbon sequestration. Although Earth observation provides values and time series for both these parameters, ...

  6. Publications | Page 122 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI collabore avec les chercheurs et les établissements des pays en développement au renforcement des capacités locales par le truchement du ... par le CRDI qui fournit des ordinateurs aux écoles tout en créant des emplois permet de s'attaquer au problème environnemental causé par les déchets électroniques en ...

  7. Élaboration de films minces de tellurure de bismuth par voie chimique

    Science.gov (United States)

    Scidone, L.; Boulanger, C.; Lecuire, J. M.; Diliberto, S.

    2004-12-01

    La miniaturisation de modules Peltier passe par la recherche de techniques de synthèse appropriées pour l’élaboration de film minces d’alliages de matériaux thermoélectriques. Les procédés de synthèse couramment rencontrés sont basés sur différents principes présentant de nombreux inconvénients techniques. Une technique plus simple d’élaboration par déposition chimique de ces matériaux de type Bi2Te3 sous forme de films minces a été étudiée. Les dépôts ont été effectués à partir de solutions de TeIV et BiIII dissous en milieu nitrique à température ambiante. La réduction de ces cations a été envisagée selon deux voies. D’une part par l’utilisation de différents réducteurs solubles et d’autre part par action de métaux purs. L’influence de la concentration en cations métalliques et le rapport BiIII/TeIV des solutions ont été étudiés. Les produits de synthèse ont été identifiés par diffraction des rayons X, l’aspect des films a été observé par microscopie électronique à balayage. Enfin, la cinétique de croissance d’un film thermoélectrique a été étudiée par suivi gravimétrique pour des temps de déposition assez longs (>30 min) et sur microbalance à quartz pour des temps de déposition courts (< 30 min).

  8. Radiological findings and healing patterns of incomplete stress fractures of the pars interarticularis

    International Nuclear Information System (INIS)

    Dunn, Andrew J.; Campbell, Robert S.D.; Mayor, Peter E.; Rees, Dai

    2008-01-01

    The objective was to retrospectively record the CT and MRI features and healing patterns of acute, incomplete stress fractures of the pars interarticularis. The CT scans of 156 adolescents referred with suspected pars interarticularis stress fractures were reviewed. Patients with incomplete (grade 2) pars fractures were included in the study. Fractures were assessed on CT according to vertebral level, location of cortical involvement and direction of fracture propagation. MRI was also performed in 72 of the 156 cases. MRI images of incomplete fractures were assessed for the presence of marrow oedema and cortical integrity. Fracture healing patterns were characterised on follow-up CT imaging. Twenty-five incomplete fractures were identified in 23 patients on CT. All fractures involved the inferior or infero-medial cortex of the pars and propagated superiorly or superolaterally. Ninety-two percent of incomplete fractures demonstrated either complete or partial healing on follow-up imaging. Two (8%) cases progressed to complete fractures. Thirteen incomplete fractures in 11 patients confirmed on CT also had MRI, and 92% demonstrated oedema in the pars. Ten out of thirteen fractures (77%) showed a break in the infero-medial cortex with intact supero-lateral cortex, which correlated with the CT findings. MRI incorrectly graded one case as a complete (grade 3) fracture, and 2 cases as (grade 1) stress reaction. Six fractures had follow-up MRI, 67% showed partial or complete cortical healing, and the same number showed persistent marrow oedema. Incomplete fracture of the pars interarticularis represents a stage of the evolution of a complete stress fracture. The direction of fracture propagation is consistent, and complete healing can be achieved in most cases with appropriate clinical management. CT best demonstrates fracture size and extent, and is the most appropriate modality for follow-up. MRI is limited in its ability to fully depict the cortical integrity of

  9. Radiological findings and healing patterns of incomplete stress fractures of the pars interarticularis

    Energy Technology Data Exchange (ETDEWEB)

    Dunn, Andrew J.; Campbell, Robert S.D. [Royal Liverpool and Broadgreen University Teaching Hospitals, Department of Medical Imaging, Liverpool (United Kingdom); Mayor, Peter E. [Leighton Hospital, Department of Medical Imaging, Crewe, Cheshire (United Kingdom); Rees, Dai [Robert Jones and Agnes-Hunt Orthopaedic Hospital, Department of Orthopaedic Surgery, Oswestry, Shropshire (United Kingdom)

    2008-05-15

    The objective was to retrospectively record the CT and MRI features and healing patterns of acute, incomplete stress fractures of the pars interarticularis. The CT scans of 156 adolescents referred with suspected pars interarticularis stress fractures were reviewed. Patients with incomplete (grade 2) pars fractures were included in the study. Fractures were assessed on CT according to vertebral level, location of cortical involvement and direction of fracture propagation. MRI was also performed in 72 of the 156 cases. MRI images of incomplete fractures were assessed for the presence of marrow oedema and cortical integrity. Fracture healing patterns were characterised on follow-up CT imaging. Twenty-five incomplete fractures were identified in 23 patients on CT. All fractures involved the inferior or infero-medial cortex of the pars and propagated superiorly or superolaterally. Ninety-two percent of incomplete fractures demonstrated either complete or partial healing on follow-up imaging. Two (8%) cases progressed to complete fractures. Thirteen incomplete fractures in 11 patients confirmed on CT also had MRI, and 92% demonstrated oedema in the pars. Ten out of thirteen fractures (77%) showed a break in the infero-medial cortex with intact supero-lateral cortex, which correlated with the CT findings. MRI incorrectly graded one case as a complete (grade 3) fracture, and 2 cases as (grade 1) stress reaction. Six fractures had follow-up MRI, 67% showed partial or complete cortical healing, and the same number showed persistent marrow oedema. Incomplete fracture of the pars interarticularis represents a stage of the evolution of a complete stress fracture. The direction of fracture propagation is consistent, and complete healing can be achieved in most cases with appropriate clinical management. CT best demonstrates fracture size and extent, and is the most appropriate modality for follow-up. MRI is limited in its ability to fully depict the cortical integrity of

  10. Plant-derived SAC domain of PAR-4 (Prostate Apoptosis Response 4 exhibits growth inhibitory effects in prostate cancer cells

    Directory of Open Access Journals (Sweden)

    Shayan eSarkar

    2015-10-01

    Full Text Available The gene Par-4 (Prostate Apoptosis Response 4 was originally identified in prostate cancer cells undergoing apoptosis and its product Par-4 showed cancer specific pro-apoptotic activity. Particularly, the SAC domain of Par-4 (SAC-Par-4 selectively kills cancer cells leaving normal cells unaffected. The therapeutic significance of bioactive SAC-Par-4 is enormous in cancer biology; however, its large scale production is still a matter of concern. Here we report the production of SAC-Par-4-GFP fusion protein coupled to translational enhancer sequence (5′ AMV and apoplast signal peptide (aTP in transgenic Nicotiana tabacum cv. Samsun NN plants under the control of a unique recombinant promoter M24. Transgene integration was confirmed by genomic DNA PCR, Southern and Northern blotting, Real-time PCR and Nuclear run-on assays. Results of Western blot analysis and ELISA confirmed expression of recombinant SAC-Par-4-GFP protein and it was as high as 0.15% of total soluble protein. In addition, we found that targeting of plant recombinant SAC-Par-4-GFP to the apoplast and endoplasmic reticulum (ER was essential for the stability of plant recombinant protein in comparison to the bacterial derived SAC-Par-4. Deglycosylation analysis demonstrated that ER-targeted SAC-Par-4-GFP-SEKDEL undergoes O-linked glycosylation unlike apoplast-targeted SAC-Par-4-GFP. Furthermore, various in vitro studies like mammalian cells proliferation assay (MTT, apoptosis induction assays, and NF-κB suppression suggested the cytotoxic and apoptotic properties of plant-derived SAC-Par-4-GFP against multiple prostate cancer cell lines. Additionally, pre-treatment of MAT-LyLu prostate cancer cells with purified SAC-Par-4-GFP significantly delayed the onset of tumor in a syngeneic rat prostate cancer model. Taken altogether, we proclaim that plant made SAC-Par-4 may become a useful alternate therapy for effectively alleviating cancer in the new era.

  11. La structure de l'eau liquide: Une etude thermique par spectroscopie infrarouge

    Science.gov (United States)

    Larouche, Pascal

    Le probleme de la structure de l'eau liquide est important car l'eau est le liquide le plus present sur Terre, et complexe, la quete d'un modele precis pour decrire comment fonctionne ce liquide ayant debute des la fin du dix-neuvieme siecle. Cette etude aborde ce probleme en etudiant l'effet de l'augmentation de la temperature sur H2O et D 2O purs a l'aide de la spectroscopie infrarouge. L'intervalle de temperatures scrute est 29--93.1°C. Les spectres enregistres sont des spectres MIR-ATR entre 650 et 6000 cm-1 . L'analyse par facteurs de ces donnees permet de montrer que deux et seulement deux facteurs principaux sont necessaires pour decomposer tous les spectres experimentaux. Ces resultats sont confirmes grace a l'analyse par facteurs de spectres de la region FIR. Par la suite, la transformation en spectres de la partie reelle n et imaginaire k de l'indice de refraction permet de combiner les donnees des regions MIR et FIR. Une fois ce calcul termine, les spectres de transmission complets de H 2O et D2O entre 25 et 90°C sont connus. Ils sont ensuite utilises pour calculer par extrapolation le spectre des especes constituant l'eau liquide, puis leur abondance en fonction de la temperature. L'extrapolation de ces abondances montre que les especes correspondent a des temperatures limites de --18 et 122°C. Par la suite, la decomposition gaussienne des spectres d'especes met en evidence la riche structure de ces objets et permet de demontrer que l'apparent deplacement du massif d'absorption OH (OD) est produit par une variation de l'intensite des bandes et non pas de leur deplacement. L'examen attentif des spectres des especes prouve qu'il n'y a pas de OH libres crees par l'augmentation de la temperature: meme a 93.1°C, chaque molecule possede quatre liens-H. Ces conclusions sont de plus confirmees par une analyse thermodynamique du passage des molecules de la phase solide a la phase gazeuse. Pour diversifier la nature des resultats experimentaux utilises, des

  12. Spondylolysis outcomes in adolescents after direct screw repair of the pars interarticularis.

    Science.gov (United States)

    Snyder, Laura A; Shufflebarger, Harry; O'Brien, Michael F; Thind, Harjot; Theodore, Nicholas; Kakarla, Udaya K

    2014-09-01

    Isthmic spondylolysis can significantly decrease functional abilities, especially in adolescent athletes. Although treatment can range from observation to surgery, direct screw placement through the fractured pars, or Buck's procedure, may be a more minimally invasive procedure than the more common pedicle screw-hook construct. Review of surgical databases identified 16 consecutive patients treated with Buck's procedure from 2004 to 2010. Twelve patients were treated at Miami Children's Hospital and 4 at Barrow Neurological Institute. Demographics and clinical and radiographic outcomes were recorded and analyzed retrospectively. The 16 patients had a median age of 16 years, and 14 were 20 years or younger at the time of treatment. Symptoms included axial back pain in 100% of patients with concomitant radiculopathy in 38%. Pars defects were bilateral in 81% and unilateral in 19% for a total of 29 pars defects treated using Buck's procedure. Autograft or allograft augmented with recombinant human bone morphogenetic protein as well as postoperative bracing was used in all cases. Postoperatively, symptoms resolved completely or partially in 15 patients (94%). Of 29 pars defects, healing was observed in 26 (89.6%) prior to 1 revision surgery, and an overall fusion rate of 97% was observed at last radiological follow-up. There were no implant failures. All 8 athletes in this group had returned to play at last follow-up. Direct screw repair of the pars interarticularis defect as described in this series may provide a more minimally invasive treatment of adolescent patients with satisfactory clinical and radiological outcomes, including return to play of adolescent athletes.

  13. Incorporating GOES Satellite Photosynthetically Active Radiation (PAR) Retrievals to Improve Biogenic Emission Estimates in Texas

    Science.gov (United States)

    Zhang, Rui; White, Andrew T.; Pour Biazar, Arastoo; McNider, Richard T.; Cohan, Daniel S.

    2018-01-01

    This study examines the influence of insolation and cloud retrieval products from the Geostationary Operational Environmental Satellite (GOES) system on biogenic emission estimates and ozone simulations in Texas. Compared to surface pyranometer observations, satellite-retrieved insolation and photosynthetically active radiation (PAR) values tend to systematically correct the overestimation of downwelling shortwave radiation in the Weather Research and Forecasting (WRF) model. The correlation coefficient increases from 0.93 to 0.97, and the normalized mean error decreases from 36% to 21%. The isoprene and monoterpene emissions estimated by the Model of Emissions of Gases and Aerosols from Nature are on average 20% and 5% less, respectively, when PAR from the direct satellite retrieval is used rather than the control WRF run. The reduction in biogenic emission rates using satellite PAR reduced the predicted maximum daily 8 h ozone concentration by up to 5.3 ppbV over the Dallas-Fort Worth (DFW) region on some days. However, episode average ozone response is less sensitive, with a 0.6 ppbV decrease near DFW and 0.3 ppbV increase over East Texas. The systematic overestimation of isoprene concentrations in a WRF control case is partially corrected by using satellite PAR, which observes more clouds than are simulated by WRF. Further, assimilation of GOES-derived cloud fields in WRF improved CAMx model performance for ground-level ozone over Texas. Additionally, it was found that using satellite PAR improved the model's ability to replicate the spatial pattern of satellite-derived formaldehyde columns and aircraft-observed vertical profiles of isoprene.

  14. Pars plana vitrectomy and silicone oil tamponade for acute endophthalmitis treatment Vitrectomia pars plana e tamponamento por óleo de silicone para o tratamento de endoftalmite aguda

    Directory of Open Access Journals (Sweden)

    Rubens Camargo Siqueira

    2009-02-01

    Full Text Available PURPOSE: To evaluate the outcomes of pars plana vitrectomy and silicone oil injection for the treatment of infectious endophthalmitis. METHODS: 35 cases of endophthalmitis secondary to phacoemulsification (20 patients, trabeculectomy (8 patients, perforating trauma (2 patients, trauma (2 patients, corneal transplantation (1 patient, vitrectomy (1 patient and corneal ulceration (1 patient were retrospectively studied. Patients were separated into two groups: Group 1 (n=24: intravitreal antibiotic injection, associated with topical and oral antibiotics; Group 2 (n=11: vitrectomy with intravitreal antibiotic injection and silicone oil injection. The follow-up ranged from 1 to 48 months (mean of 16 months. RESULTS: From 24 patients in group 1, 11 patients (45.83%, had infection controlled with intravitreal antibiotic injection only; 13 patients (54.15% regressed to uncontrolled endophthalmitis, in which two patients (8.33% were submitted to evisceration and one patient (4.16% had corneal melting. The remaining 10 patients (41.66% with uncontrolled endophthalmitis were submitted to pars plana vitrectomy and silicone oil injection. Six patients (25% from Group I had retinal detachment during the first month of follow-up and also required pars plana vitrectomy and silicone oil injection. In Group 2 patients (n=11, all of them had controlled infection at the first procedure. In one case (9.09%, a severe proliferatative vitreoretinopathy induced loss of vision. CONCLUSION: These results suggest that silicone oil tamponade might be beneficial in the treatment strategy of infectious endophthalmitis.OBJETIVO: Avaliar os resultados da vitrectomia pars plana com tamponamento com óleo de silicone no tratamento de endoftalmite aguda. MÉTODOS: Trinta e cinco pacientes com endoftalmite, sendo 20 secundário à facoemulsificação, 8 por trabeculectomia, 2 por trauma perfurante, 2 por trauma, 1 por transplante de córnea, 1 por vitrectomia, e 1 por úlcera de c

  15. stratégie des déffense biochimique mise en ouevre par les olives attaquées par le ravageur

    OpenAIRE

    Meziani, Medjdoub Kenza

    2014-01-01

    Ce travail est présenté en trois parties: -La première partie est une revue bibliographique qui englobe l'olivier, sa description botanique et ses maladies ainsi que ses principaux ravageurs, dont particulièrement Bactrocera oleae, avec sa bio-écologie, et les différentes méthodes de lutte les plus pratiquées contre lui. Enfin une étude concernant les composés phénoliques et leur rôle dans la défense des plantes contre les agressions biotiques et abiotiques. -La deuxième par...

  16. Regular cellular distribution of plasmids by oscillating and filament-forming ParA ATPase of plasmid pB171

    DEFF Research Database (Denmark)

    Ebersbach, Gitte; Ringgaard, Simon; Møller-Jensen, Jakob

    2006-01-01

    Centromere-like loci from bacteria segregate plasmids to progeny cells before cell division. The ParA ATPase (a MinD homologue) of the par2 locus from plasmid pB171 forms oscillating helical structures over the nucleoid. Here we show that par2 distributes plasmid foci regularly along the length...... of the cell even in cells with many plasmids. In vitro, ParA binds ATP and ADP and has a cooperative ATPase activity. Moreover, ParA forms ATP-dependent filaments and cables, suggesting that ParA can provide the mechanical force for the observed regular distribution of plasmids. ParA and ParB interact...

  17. Decontamination tests on tritium-contaminated materials; Essais de decontamination de materiel contamine par du tritium

    Energy Technology Data Exchange (ETDEWEB)

    Boutot, P.; Schipfer, P. [Commissariat a l' Energie Atomique, Chusclan (France). Centre de Production de Plutonium de Marcoule

    1967-07-01

    These tests are designed to try out various processes liable to be applied to the decontamination of a material contaminated with tritium. The samples are thin stainless- steel slabs contaminated in the laboratory with elements extracted from industrial installations. The measurement of the initial and residual activities is carried out using an open-window BERTHOLD counter. The best results are obtained by passing a current of pre-heated (300 deg. C) air containing water vapour. This process makes it possible to reach a decontamination factor of 99.5 per cent in 4 hours. In a vacuum, the operation has to be prolonged to 100 hours in order to obtain a decontamination factor of 99.2 per cent. Wet-chemical or electrolytic treatments are efficient but their use is limited by the inherent corrosion risks. A study of the reappearance of the contamination has made it possible to observe that this phenomenon occurs whatever the process used. (authors) [French] Ces essais ont pour but d'experimenter divers procedes susceptibles d'etre appliques a la decontamination du materiel contamine par du tritium. Les echantillons sont constitues par des plaquettes d'acier inoxydable contamines en laboratoire et par des elements extraits d'installations industrielles. Les mesures d'activites initiales et residuelles sont effectuees au moyen d'un compteur BERTHOLD a fenetre ouverte. Les meilleurs resultats sont obtenus par balayage d'air prechauffe a 300 deg. C et additionne de vapeur d'eau. Ce procede permet d'atteindre en 4 heures un facteur de decontamination de 99,5 pour cent. Sous vide, l'operation doit etre poursuivie pendant 100 heures pour porter le facteur de decontamination a 99,2 pour cent. Les traitements par voie chimique humide et par voie electrolytique sont efficaces mais la corrosion qu'ils risquent d'engendrer limite considerablement leur champ d'application. Une etude sur la resurgence de la

  18. Screening of phytochemicals against protease activated receptor 1 (PAR1), a promising target for cancer.

    Science.gov (United States)

    Kakarala, Kavita Kumari; Jamil, Kaiser

    2015-02-01

    Drug resistance and drug-associated toxicity are the primary causes for withdrawal of many drugs, although patient recovery is satisfactory in many instances. Interestingly, the use of phytochemicals in the treatment of cancer as an alternative to synthetic drugs comes with a host of advantages; minimum side effects, good human absorption and low toxicity to normal cells. Protease activated receptor 1 (PAR1) has been established as a promising target in many diseases including various cancers. Strong evidences suggest its role in metastasis also. There are no natural compounds known to inhibit its activity, so we aimed to identify phytochemicals with antagonist activity against PAR1. We screened phytochemicals from Naturally Occurring Plant-based Anticancer Compound-Activity-Target database (NPACT, http://crdd.osdd.net/raghava/npact/ ) against PAR1 using virtual screening workflow of Schrödinger software. It analyzes pharmaceutically relevant properties using Qikprop and calculates binding energy using Glide at three accuracy levels (high-throughput virtual screening, standard precision and extra precision). Our study led to the identification of phytochemicals, which showed interaction with at least one experimentally determined active site residue of PAR1, showed no violations to Lipinski's rule of five along with predicted high human absorption. Furthermore, structural interaction fingerprint analysis indicated that the residues H255, D256, E260, S344, V257, L258, L262, Y337 and S344 may play an important role in the hydrogen bond interactions of the phytochemicals screened. Of these residues, H255 and L258 residues were experimentally proved to be important for antagonist binding. The residues Y183, L237, L258, L262, F271, L332, L333, Y337, L340, A349, Y350, A352, and Y353 showed maximum hydrophobic interactions with the phytochemicals screened. The results of this work suggest that phytochemicals Reissantins D, 24,25-dihydro-27-desoxywithaferin A, Isoguaiacin

  19. The role of gyrA and parC mutations in fluoroquinolones-resistant Pseudomonas aeruginosa isolates from Iran.

    Science.gov (United States)

    Nouri, Roghayeh; Ahangarzadeh Rezaee, Mohammad; Hasani, Alka; Aghazadeh, Mohammad; Asgharzadeh, Mohammad

    The aim of this study was to examine mutations in the quinolone-resistance-determining region (QRDR) of gyrA and parC genes in Pseudomonas aeruginosa isolates. A total of 100 clinical P. aeruginosa isolates were collected from different university-affiliated hospitals in Tabriz, Iran. Minimum inhibitory concentrations (MICs) of ciprofloxacin and levofloxacin were evaluated by agar dilution assay. DNA sequences of the QRDR of gyrA and parC were determined by the dideoxy chain termination method. Of the total 100 isolates, 64 were resistant to ciprofloxacin. No amino acid alterations were detected in gyrA or parC genes of the ciprofloxacin susceptible or ciprofloxacin intermediate isolates. Thr-83 → Ile substitution in gyrA was found in all 64 ciprofloxacin resistant isolates. Forty-four (68.75%) of them had additional substitution in parC. A correlation was found between the number of the amino acid alterations in the QRDR of gyrA and parC and the level of ciprofloxacin and levofloxacin resistance of the P. aeruginosa isolates. Ala-88 → Pro alteration in parC was generally found in high level ciprofloxacin resistant isolates, which were suggested to be responsible for fluoroquinolone resistance. These findings showed that in P. aeruginosa, gyrA was the primary target for fluoroquinolone and additional mutation in parC led to highly resistant isolates. Copyright © 2016 Sociedade Brasileira de Microbiologia. Published by Elsevier Editora Ltda. All rights reserved.

  20. The role of gyrA and parC mutations in fluoroquinolones-resistant Pseudomonas aeruginosa isolates from Iran

    Directory of Open Access Journals (Sweden)

    Roghayeh Nouri

    Full Text Available Abstract The aim of this study was to examine mutations in the quinolone-resistance-determining region (QRDR of gyrA and parC genes in Pseudomonas aeruginosa isolates. A total of 100 clinical P. aeruginosa isolates were collected from different university-affiliated hospitals in Tabriz, Iran. Minimum inhibitory concentrations (MICs of ciprofloxacin and levofloxacin were evaluated by agar dilution assay. DNA sequences of the QRDR of gyrA and parC were determined by the dideoxy chain termination method. Of the total 100 isolates, 64 were resistant to ciprofloxacin. No amino acid alterations were detected in gyrA or parC genes of the ciprofloxacin susceptible or ciprofloxacin intermediate isolates. Thr-83 → Ile substitution in gyrA was found in all 64 ciprofloxacin resistant isolates. Forty-four (68.75% of them had additional substitution in parC. A correlation was found between the number of the amino acid alterations in the QRDR of gyrA and parC and the level of ciprofloxacin and levofloxacin resistance of the P. aeruginosa isolates. Ala-88 → Pro alteration in parC was generally found in high level ciprofloxacin resistant isolates, which were suggested to be responsible for fluoroquinolone resistance. These findings showed that in P. aeruginosa, gyrA was the primary target for fluoroquinolone and additional mutation in parC led to highly resistant isolates.

  1. Protease-activated receptor-2 (PAR-2) in the rat gastric mucosa: immunolocalization and facilitation of pepsin/pepsinogen secretion

    Science.gov (United States)

    Kawao, Naoyuki; Sakaguchi, Yuriko; Tagome, Ai; Kuroda, Ryotaro; Nishida, Shozo; Irimajiri, Kiyohiro; Nishikawa, Hiroyuki; Kawai, Kenzo; Hollenberg, Morley D; Kawabata, Atsufumi

    2002-01-01

    Agonists of protease-activated receptor-2 (PAR-2) trigger neurally mediated mucus secretion accompanied by mucosal cytoprotection in the stomach. The present study immunolocalized PAR-2 in the rat gastric mucosa and examined if PAR-2 could modulate pepsin/pepsinogen secretion in rats. PAR-2-like immunoreactivity was abundant in the deep regions of gastric mucosa, especially in chief cells. The PAR-2 agonist SLIGRL-NH2, but not the control peptide LSIGRL-NH2, administered i.v. repeatedly at 0.3 – 1 μmol kg−1, four times in total, significantly facilitated gastric pepsin secretion, although a single dose produced no significant effect. The PAR-2-mediated gastric pepsin secretion was resistant to omeprazole, NG-nitro-L-arginine methyl ester (L-NAME) or atropine, and also to ablation of sensory neurons by capsaicin. Our study thus provides novel evidence that PAR-2 is localized in mucosal chief cells and facilitates gastric pepsin secretion in the rats, most probably by a direct mechanism. PMID:11877338

  2. Encontro de Aedes albopictus no Estado do Pará, Brasil Occurrence of Aedes albopictus in the state of Pará, Brazil

    Directory of Open Access Journals (Sweden)

    Maria de Nazaré de Oliveira Segura

    2003-06-01

    Full Text Available Pela primeira vez é registrada a presença do Aedes (Stg albopictus no Estado do Pará, Brasil, em área urbana no município de Medicilândia distante cerca de 90 km de Altamira, onde foram capturados por meio de isca humana 42 exemplares de mosquitos adultos. Estes foram inoculados em C6/36 e em camundongos recém-nascidos na tentativa de isolamento viral, não tendo sido isolado nenhum vírus. A presença de Aedes albopictus em áreas da Amazônia onde circulam os vírus de dengue e de febre amarela é preocupante e representa um risco potencial desta espécie de mosquito se tornar infectada com tais vírus.It is first reported the detection of Aedes (Stg albopictus mosquitoes in state of Pará, Brazil, in the urban area of Medicilândia, a municipality far 90 km from Altamira, where 42 adult mosquitoes were baited using human attraction. All mosquitoes were pooled and inoculated into C6/36 and suckling mice in attempts for virus isolation. No virus was isolated. The occurrence of Aedes albopictus in urban areas of the Amazon region is of concern since dengue and yellow fever viruses are endemic in the Amazon and thus there is a potential risk for this mosquito species to become infected with both viruses.

  3. Synthèse de monoglycérides par transestérification catalysée par des oxydes basiques

    Directory of Open Access Journals (Sweden)

    Bancquart Sébastien

    2001-05-01

    Full Text Available La préparation de monoglycérides à partir d’acides ou d’esters méthyliques gras et de glycérol peut être effectuée en présence de catalyseurs acides ou basiques. L’emploi de catalyseurs basiques solides pourrait limiter les réactions secondaires menant à la dégradation des réactifs, notamment du glycérol. Une comparaison de plusieurs solides basiques (MgO, CeO2, La2O3 et ZnO a montré que plus la basicité intrinsèque du catalyseur est importante, plus il est actif. Afin d’augmenter les performances de ces solides, plusieurs méthodes ont été utilisées pour la préparation de MgO. Un dopage alcalin a ensuite été tenté afin d’augmenter la basicité et l’activité de MgO. L’oxyde de magnésium préparé par hydratation d’un oxyde commercial et dopé au lithium, suivi de sa déshydratation, est le catalyseur le plus actif.

  4. Cell-Penetrating Function of the Poly(ADP-Ribose (PAR-Binding Motif Derived from the PAR-Dependent E3 Ubiquitin Ligase Iduna

    Directory of Open Access Journals (Sweden)

    Ja-Hyun Koo

    2018-03-01

    Full Text Available Iduna is a poly(ADP-ribose (PAR-dependent E3 ubiquitin ligase that regulates cellular responses such as proteasomal degradation and DNA repair upon interaction with its substrate. We identified a highly cationic region within the PAR-binding motif of Iduna; the region was similar among various species and showed amino acid sequence similarity with that of known cell-penetrating peptides (CPPs. We hypothesized that this Iduna-derived cationic sequence-rich peptide (Iduna could penetrate the cell membrane and deliver macromolecules into cells. To test this hypothesis, we generated recombinant Iduna-conjugated enhanced green fluorescent protein (Iduna-EGFP and its tandem-repeat form (d-Iduna-EGFP. Both Iduna-EGFP and d-Iduna-EGFP efficiently penetrated Jurkat cells, with the fluorescence signals increasing dose- and time-dependently. Tandem-repeats of Iduna and other CPPs enhanced intracellular protein delivery efficiency. The delivery mechanism involves lipid-raft-mediated endocytosis following heparan sulfate interaction; d-Iduna-EGFP was localized in the nucleus as well as the cytoplasm, and its residence time was much longer than that of other controls such as TAT and Hph-1. Moreover, following intravenous administration to C57/BL6 mice, d-Iduna-EGFP was efficiently taken up by various tissues, including the liver, spleen, and intestine suggesting that the cell-penetrating function of the human Iduna-derived peptide can be utilized for experimental and therapeutic delivery of macromolecules.

  5. Linear study and bundle adjustment data fusion; Application to vision localization; Recherche lineaire et fusion de donnees par ajustement de faisceaux; Application a la localisation par vision

    Energy Technology Data Exchange (ETDEWEB)

    Michot, J.

    2010-12-09

    integrate this additional information directly into an extended bundle adjustment, by adding a constraint term in the weighted cost function. We evaluate three methods (based on machine learning or regularization) that dynamically select the weight associated to the constraint and show that these methods can be used in a real time multi-sensor SLAM, and validate them with different types of constraint on the orientation or on the scale. Experiments conducted on real video sequences show that this technique of constrained bundle adjustment reduces the drifts observed with the classical vision algorithms and improves the global accuracy of the positioning system. (author) [French] Les travaux presentes dans ce manuscrit concernent le domaine de la localisation et la reconstruction 3D par vision artificielle. Dans ce contexte, la trajectoire d'une camera et la structure 3D de la scene filmee sont initialement estimees par des algorithmes lineaires puis optimisees par un algorithme non-lineaire, l'ajustement de faisceaux. Cette these presente tout d'abord une technique de recherche de l'amplitude de deplacement (recherche lineaire), ou line search pour les algorithmes de minimisation iterative. La technique proposee est non iterative et peut etre rapidement implantee dans un ajustement de faisceaux traditionnel. Cette technique appelee recherche lineaire algebrique globale (G-ALS), ainsi que sa variante a deux dimensions (Two way-ALS), accelerent la convergence de l'algorithme d'ajustement de faisceaux. L'approximation de l'erreur de reprojection par une distance algebrique rend possible le calcul analytique d'une amplitude de deplacement efficace (ou de deux pour la variante Two way-ALS), par la resolution d'un polynome de degre 3 (G-ALS) ou 5 (Two way-ALS). Nos experimentations sur des donnees simulees et reelles montrent que cette amplitude, optimale en distance algebrique, est performante en distance euclidienne, et permet

  6. Regular cellular distribution of plasmids by oscillating and filament-forming ParA ATPase of plasmid pB171

    DEFF Research Database (Denmark)

    Ebersbach, Gitte; Ringgaard, Simon; Møller-Jensen, Jakob

    2006-01-01

    Centromere-like loci from bacteria segregate plasmids to progeny cells before cell division. The ParA ATPase (a MinD homologue) of the par2 locus from plasmid pB171 forms oscillating helical structures over the nucleoid. Here we show that par2 distributes plasmid foci regularly along the length o...

  7. Cross-talk between toll-like receptor 4 (TLR4) and proteinase-activated receptor 2 (PAR(2) ) is involved in vascular function.

    Science.gov (United States)

    Bucci, M; Vellecco, V; Harrington, L; Brancaleone, V; Roviezzo, F; Mattace Raso, G; Ianaro, A; Lungarella, G; De Palma, R; Meli, R; Cirino, G

    2013-01-01

    Proteinase-activated receptors (PARs) and toll-like receptors (TLRs) are involved in innate immune responses. The aim of this study was to evaluate the possible cross-talk between PAR(2) and TLR4 in vessels in physiological condition and how it varies following stimulation of TLR4 by using in vivo and ex vivo models. Thoracic aortas were harvested from both naïve and endotoxaemic rats for in vitro studies. Arterial blood pressure was monitored in anaesthetized rats in vivo. LPS was used as a TLR4 agonist while PAR(2) activating peptide (AP) was used as a PAR(2) agonist. Aortas harvested from TLR4(-/-) mice were also used to characterize the PAR(2) response. PAR(2) , but not TLR4, expression was enhanced in aortas of endotoxaemic rats. PAR(2) AP-induced vasorelaxation was increased in aortic rings of LPS-treated rats. TLR4 inhibitors, curcumine and resveratrol, reduced PAR(2) AP-induced vasorelaxation and PAR(2) AP-induced hypotension in both naïve and endotoxaemic rats. Finally, in aortic rings from TLR4(-/-) mice, the expression of PAR(2) was reduced and the PAR(2) AP-induced vasodilatation impaired compared with those from wild-type mice and both resveratrol and curcumine were ineffective. Cross-talk between PAR(2) and TLR4 contributes to vascular homeostasis. © 2012 The Authors. British Journal of Pharmacology © 2012 The British Pharmacological Society.

  8. Cross-talk between toll-like receptor 4 (TLR4) and proteinase-activated receptor 2 (PAR2) is involved in vascular function

    Science.gov (United States)

    Bucci, M; Vellecco, V; Harrington, L; Brancaleone, V; Roviezzo, F; Mattace Raso, G; Ianaro, A; Lungarella, G; De Palma, R; Meli, R; Cirino, G

    2013-01-01

    Background and Purpose Proteinase-activated receptors (PARs) and toll-like receptors (TLRs) are involved in innate immune responses. The aim of this study was to evaluate the possible cross-talk between PAR2 and TLR4 in vessels in physiological condition and how it varies following stimulation of TLR4 by using in vivo and ex vivo models. Experimental Approach Thoracic aortas were harvested from both naïve and endotoxaemic rats for in vitro studies. Arterial blood pressure was monitored in anaesthetized rats in vivo. LPS was used as a TLR4 agonist while PAR2 activating peptide (AP) was used as a PAR2 agonist. Aortas harvested from TLR4–/– mice were also used to characterize the PAR2 response. Key Results PAR2, but not TLR4, expression was enhanced in aortas of endotoxaemic rats. PAR2AP-induced vasorelaxation was increased in aortic rings of LPS-treated rats. TLR4 inhibitors, curcumine and resveratrol, reduced PAR2AP-induced vasorelaxation and PAR2AP-induced hypotension in both naïve and endotoxaemic rats. Finally, in aortic rings from TLR4–/– mice, the expression of PAR2 was reduced and the PAR2AP-induced vasodilatation impaired compared with those from wild-type mice and both resveratrol and curcumine were ineffective. Conclusions and Implications Cross-talk between PAR2 and TLR4 contributes to vascular homeostasis. PMID:22957757

  9. [Roles of protease-activated receptor-2 (PAR-2), a G protein-coupled receptor, in modulation of exocrine gland functions].

    Science.gov (United States)

    Nishikawa, Hiroyuki

    2006-07-01

    Protease-activated receptor-2 (PAR-2), a G protein-coupled receptor, is activated by proteolytic unmasking of the N-terminal extracellular tethered ligand that presumably binds to the extracellular loop 2 of the receptor itself. PAR-2 is widely distributed in the mammalian body and plays various roles in biological events in the cardiovascular, respiratory, alimentary, and central neurons systems. PAR-2-activating peptides administered systemically to mice and rats trigger prompt salivation in vivo. In an in vitro study, PAR-2 agonists including the endogenous PAR-2 activator trypsin induce secretion of amylase and mucin from isolated rat parotid glands and sublingual glands, respectively. PAR-2-activating peptides administered systemically also modulate pancreatic exocrine secretion in vivo as well as in vitro. In the gastric mucosa, PAR-2 stimulation enhances secretion of mucus and pepsinogen and suppresses acid secretion. Tear secretion can also be caused by PAR-2-related peptides in PAR-2-dependent and -independent manners. PAR-2 thus plays a general or key role in the regulation of exocrine secretion. This review focuses on the physiologic and/or pathophysiologic roles of PAR-2 in glandular exocrine secretion. The possibility of PAR-2 as a target for drug development is also discussed.

  10. Modelagem matemática da secagem da pimenta Cumari do Pará Mathematical modeling of drying kinetics of pepper Cumarí do Pará

    Directory of Open Access Journals (Sweden)

    Renata C. Reis

    2011-04-01

    Full Text Available Objetivou-se, neste trabalho, determinar e modelar as curvas de secagem da pimenta Cumari do Pará (Capsicum chinense Jacqui, nas temperaturas de 45, 55 e 65 ºC e estimar seu coeficiente de difusão. As pimentas foram coletadas no município de Ceres, GO, e transportadas para UEG - Anápolis, GO; a secagem foi conduzida em secador experimental com controle de temperatura e fluxo de ar de 60 m³ min-1 m-2; os dados experimentais foram ajustados aos nove modelos matemáticos; as magnitudes do coeficiente de determinação (R², do erro médio relativo (P e do erro médio estimado (SE foram utilizadas para verificar o grau de ajuste dos modelos. Concluiu-se que: a o comportamento das curvas de secagem da pimenta Cumari do Pará foi semelhante ao da maioria dos produtos agrícolas; b o tempo de secagem foi de 4 h; 2 h e 50 min e 1 h e 55 min para as temperaturas de secagem de 45, 55 e 65 ºC, respectivamente; c o modelo matemático de secagem de Midilli et al. (2002, foi o que melhor se ajustou aos dados experimentais; d os valores do coeficiente de difusão aumentaram de acordo com a elevação da temperatura do ar de secagem, apresentando resultados entre 2,29 10-11 e 2,57 10-11 m² s-1.Among the processes of food preservation, drying the product stands out for maintaining the nutritional quality and flavor of products. The objective of this study was to determine and adjust the curves of drying of Pará Cumari pepper (Capsicum chinense Jacqui, at temperatures of 45, 55 and 65 ºC. The Pará Cumari peppers were collected in the city of Ceres, GO and transported to UEG - Anápolis, GO. Drying was conducted in fixed bed dryer with temperature control and airflow of 60 m³ min-1 m-2. Experimental data were adjusted to nine mathematical models. The magnitude of the coefficient of determination (R², the mean relative error (P and the estimated mean error (SE were used to verify the degree of fit of the models. It was concluded that: a the behavior of

  11. Activation of PAR2 receptors sensitizes primary afferents and causes leukocyte rolling and adherence in the rat knee joint

    Science.gov (United States)

    Russell, FA; Schuelert, N; Veldhoen, VE; Hollenberg, MD; McDougall, JJ

    2012-01-01

    Background and Purpose The PAR2 receptors are involved in chronic arthritis by mechanisms that are as yet unclear. Here, we examined PAR2 activation in the rat knee joint. Experimental Approach PAR2 in rat knee joint dorsal root ganglia (DRG) cells at L3-L5, retrogradely labelled with Fluoro-gold (FG) were demonstrated immunohistochemically. Electrophysiological recordings from knee joint nerve fibres in urethane anaesthetized Wistar rats assessed the effects of stimulating joint PAR2 with its activating peptide, 2-furoyl-LIGRLO-NH2 (1–100 nmol·100 μL−1, via close intra-arterial injection). Fibre firing rate was recorded during joint rotations before and 15 min after administration of PAR2 activating peptide or control peptide. Leukocyte kinetics in the synovial vasculature upon PAR2 activation were followed by intravital microscopy for 60 min after perfusion of 2-furoyl-LIGRLO-NH2 or control peptide. Roles for transient receptor potential vanilloid-1 (TRPV1) or neurokinin-1 (NK1) receptors in the PAR2 responses were assessed using the selective antagonists, SB366791 and RP67580 respectively. Key Results PAR2 were expressed in 59 ± 5% of FG-positive DRG cells; 100 nmol 2-furoyl-LIGRLO-NH2 increased joint fibre firing rate during normal and noxious rotation, maximal at 3 min (normal; 110 ± 43%, noxious; 90 ± 31%). 2-Furoyl-LIGRLO-NH2 also significantly increased leukocyte rolling and adhesion over 60 min. All these effects were blocked by pre-treatment with SB366791 and RP67580 (P knee joint via TRPV1- and NK1-dependent mechanisms involving both PAR2-mediated neuronal sensitization and leukocyte trafficking. PMID:22849826

  12. Utility of the plasma level of suPAR in monitoring risk of mortality during TB treatment

    DEFF Research Database (Denmark)

    Rabna, Paulo; Andersen, Andreas; Wejse, Christian

    2012-01-01

    Objective: To investigate whether changes in the plasma level of soluble urokinase plasminogen activator receptor (suPAR) can be used to monitor tuberculosis (TB) treatment efficacy. Design: This prospective cohort study included 278 patients diagnosed with active pulmonary TB and followed...... that elevated suPAR level at time of initiation of TB treatment is associated with increased risk of mortality. Furthermore, increased suPAR levels after one month of treatment was associated with increased risk of mortality during the remaining 7-month treatment period....

  13. Analysis of gyrA and parC mutations in enterococci from environmental samples with reduced susceptibility to ciprofloxacin

    DEFF Research Database (Denmark)

    Petersen, A.; Jensen, Lars Bogø

    2004-01-01

    The quinolone resistance determining regions of gyrA and parC in four species of enterococci from environmental samples with reduced susceptibility to ciprofloxacin were sequenced. The nucleotide sequence variations of parC could be related to the different enterococcal species. Mutations...... in Enterococcus faecalis and Enterococcus faecium related to reduced susceptibility were identical to mutations detected in E jaecalis and E. faecium of clinical origin. A minimal inhibitory concentration of 8 mug ml(-1) to ciprofloxacin was not associated with any mutations in the gyrA and parC gene...... of Enterococcus casseliflavus and Enterococcus gallinarum. These two species may be intrinsically less susceptible to ciprofloxacin....

  14. The conditioning of radioactive waste by bitumen; Conditionnement des dechets radioactifs par le bitume

    Energy Technology Data Exchange (ETDEWEB)

    Rodier, J.; Scheidhauer, J.; Malabre, M. [Commissariat a l' Energie Atomique, Chusclan (France). Centre de Production de Plutonium de Marcoule

    1961-07-01

    The separation of radioactive sludge and waste by bitumen is studied. Results are given concerning various trials carried out on the lixiviation of the final product by water as a function of the pH, of the time, and of the composition. The conditions for carrying out this process of coating the waste are controlled from a radioactive point of view. (author) [French] L'isolement de boues radioactives et de dechets par le bitume est etudie. Les resultats de divers essais portant sur la lixiviation par l'eau du produit fini en fonction du pH, du temps et de la composition sont exposes. Les conditions de realisation de l'enrobage sont controlees au point de vue du risque radioactif. (auteur)

  15. Projet en milieu universitaire : vers une gestion collaborative assistée par le Web

    Directory of Open Access Journals (Sweden)

    Bénédicte Talon

    2005-01-01

    Full Text Available Cet article présente une méthodologie de gestion de projets étudiants assistée par le Web. Cette méthodologie met en œuvre les principes d’une pédagogie active collaborative. Elle est proposée aux étudiants de filières universitaires professionnalisées ainsi qu’à leurs tuteurs sous forme de kits. Le site Web mis en place par les étudiants assure la communication entre les différents membres du projet. Nous pensons que les étudiants soumis à cette méthodologie accroissent leur niveau de compétence en gestion de projet, ce que devrait bientôt vérifier une expérimentation en cours.

  16. K-Area and Par Pond Sewage Sludge Application Sites Groundwater Monitoring Report

    International Nuclear Information System (INIS)

    1994-04-01

    Samples from the three wells at the K-Area Sewage Sludge Application Site (KSS wells) and the three wells at the Par Pond Sewage Sludge Application Site (PSS wells) are analyzed quarterly for constituents required by South Carolina Department of Health and Environmental Control Construction Permit 13,173 and, as requested, for other constituents as part of the Savannah River Site (SRS) Groundwater Monitoring Program. Annual analyses for other constituents, primarily metals, also are required by the permit. Dichloromethane (methylene chloride) exceeded the final Primary Drinking Water Standard in a single well of the K-Area Sewage Sludge Application Site during fourth quarter 1993. Aluminum, iron, and lead, reported in excess of the SRS Flag 2 criteria at both the K-Area and Par Pond Sewage Sludge Application Sites during third quarter 1993, were not analyzed fourth quarter

  17. Parâmetros reprodutivos do curimbatá no rio Mogi-Guaçu

    OpenAIRE

    Roseli Ormanezi Ramos; Alberto Carvalho Peret; Sergio Moreira Ramos; José Sávio Colares de Melo

    2010-01-01

    Com o objetivo de obter informações sobre parâmetros da biologia reprodutiva da população de curimbatá, visando ao gerenciamento da espécie voltado para sua conservação, foram realizadas coletas mensais de peixes no período de fevereiro de 2003 a setembro de 2004 em dois pontos do rio Mogi-Guaçu. Foram capturados 176 fêmeas e 140 machos. Os parâmetros analisados foram relação peso-comprimento, fator de condição (K), índice gonadossomático (IGS), proporção sexual e abundância relativa. Os indi...

  18. ELIMINATION DES METAUX LOURDS EN SOLUTION AQUEUSE PAR DES ARGILES ALGERIENNES

    OpenAIRE

    TIZAOUI, Khadidja

    2014-01-01

    L'objectif de cette étude est d'examiner les pouvoirs de rétention des argiles (marne et Djabel Dabbegh) des métaux lourds par des procédés de dépollution (adsorption) et leurs éliminations. Parmi ces techniques utilisées l’adsorption a montré un intérêt pratique pour l’élimination des métaux lourds étudiés à savoir le cuivre, le plomb et le zinc par l'argile marneuse et argile Djabel Dabbegh. Cependant ses performances dépendent de certains facteurs (température, pH et la vitesse d’agitation...

  19. Enseigner l'anatomie par la dissection: aspects psychologiques et pédagogiques

    OpenAIRE

    Cereghetti, Andrea; Tardif, Eric

    2016-01-01

    Dans ce projet j'ai voulu étudier la perception de la pratique de dissection du cœur avec des élèves de 8ème année (actuelle 10 H) qui l'accomplissent dans le cadre du programme de science de l'école obligatoire. En effet, j'ai été surpris par les réactions extrêmement émotives de certains élèves vis-à-vis de la dissection du cœur qui la rendent unique par rapport à la plupart des autres sujets de science. L'idée était donc de répertorier les ressentis des élèves, afin de mieux comprendre leu...

  20. Dosimetry of 64Cu-DOTA-AE105, a PET tracer for uPAR imaging

    DEFF Research Database (Denmark)

    Persson, Morten; El Ali, Henrik H.; Binderup, Tina

    2014-01-01

    64Cu-DOTA-AE105 is a novel positron emission tomography (PET) tracer specific to the human urokinase-type plasminogen activator receptor (uPAR). In preparation of using this tracer in humans, as a new promising method to distinguish between indolent and aggressive cancers, we have performed PET...... studies in mice to evaluate the in vivo biodistribution and estimate human dosimetry of 64Cu-DOTA-AE105. MethodsFive mice received iv tail injection of 64Cu-DOTA-AE105 and were PET/CT scanned 1, 4.5 and 22h post injection. Volume-of-interest (VOI) were manually drawn on the following organs: heart, lung......Favorable dosimetry estimates together with previously reported uPAR PET data fully support human testing of 64Cu-DOTA-AE105....

  1. LA CONDUITE D’UN PROJET D’EXPERTISE D’EVALUATION IMMOBILIERE PAR LA QUALITE

    OpenAIRE

    KAHOUADJI, MOHAMMED RIYADH

    2014-01-01

    Ce travail consiste à mettre en place une méthodologie pour un projet d’évaluation immobilière avec les outils du management de qualité. Tout d’abord, nous avons commencé par définir l’expert, l’expertise, la valeur et les méthodes d’évaluation pour mieux caractériser l’expertise en définissant le cadre l’égale par l’utilisation d’une approche processus. Et enfin après avoir cadré les procédures d’expertise, nous avons programmé et validé une feuille de calcule Excel pour simplifier l’é...

  2. Interchanges et tarification des systèmes de paiement par carte.

    OpenAIRE

    Verdier, Marianne

    2008-01-01

    La détention et l'usage des instruments de paiement se sont considérablement développés dans les pays industrialisés. Le succès des cartes de paiement peut s'expliquer par la présence de systèmes de paiement interbancaires, comme "Visa" ou "MasterCard", organisant les interactions entre la banque du porteur, l'émetteur, et la banque du commerçant, l'acquéreur. Cette thèse s'intéresse à un mécanisme d'allocation des coûts particulier pratiqué par les plates-formes de paiement: les interchanges...

  3. Estado nutricional en niños con parálisis cerebral infantil

    Directory of Open Access Journals (Sweden)

    Drianet Castillo Peña

    2014-08-01

    Full Text Available Se realizó un estudio descriptivo, con el objetivo de caracterizar el estado nutricional de los niños que ingresaron en el Hospital Pediátrico Provincial “Mártires de las Tunas”con parálisis cerebral, en el periodo comprendido de enero a diciembre de 2012. La muestra estuvo integrada por 25 niños. La evaluación nutricional se hizo según las tablas cubanas. Se observó que predominó el sexo masculino, siendo más afectado el grupo de mayores de siete años, prevaleció la desnutrición en niños con parálisis cerebral severa. Los déficits nutricionales más frecuentes fueron la anemia, seguido de la hipoalbuminemia

  4. El lenguaje no vocálico en la parálisis cerebral infantil

    OpenAIRE

    Frutos García, Elísabet

    2014-01-01

    Este Trabajo de Fin de Grado pretende abordar la comunicación y el lenguaje en un caso concreto de Parálisis Cerebral Infantil. En primer lugar, se propondrá una fundamentación teórica en la que será posible apreciar las características generales de esta discapacidad; para establecer una relación con la comunicación y el lenguaje que presentan estas personas. A partir de este estudio sobre la Parálisis Cerebral Infantil y a modo de cierre, se diseña un programa de intervención en el que s...

  5. Classe inversée et apprentissage par les pairs dans le supérieur

    OpenAIRE

    THIERRY, SPRIET; Mourey, Bénédicte

    2015-01-01

    International audience; Nous présentons ici les réflexions en amont et en aval à l'expérimentation pédagogique que nous avons conduit cette année sur un cours de modélisation de bases de données en deuxième année de licence informatique. La mise en pratique d'une pédagogie active s'est faite au travers des principes de classe inversée et d'apprentissage par les pairs. La présentation met en évidence les gains obtenus par ces changements pédagogiques et souligne les points pratiques auxquels l...

  6. [Slaves in purgatory: the Tucunduba Leprosarium (Pará, nineteenth century)].

    Science.gov (United States)

    Henrique, Márcio Couto

    2012-12-01

    The article analyzes the experience of the slaves interned at the Tucunduba Leprosarium in Belém, state of Pará during the nineteenth century. The slaves were freed once they showed the marks of their leprosy, and expectations were that they would submit to the segregation policy meant to keep them from contact with the rest of the population. The documentation produced by Santa Casa de Misericórdia hospital in Pará and by the province's political authorities reveals the strategies the slaves devised in response to this policy; they used their numerical predominance at the leprosarium to create a network of solidarity that allowed them to recreate their lives and stand in opposition to the type of nation that the era's hygienist theories envisioned.

  7. Minimally Invasive Direct Repair of Bilateral Lumbar Spine Pars Defects in Athletes

    Directory of Open Access Journals (Sweden)

    Gabriel A. Widi

    2013-01-01

    Full Text Available Spondylolysis of the lumbar spine has traditionally been treated using a variety of techniques ranging from conservative care to fusion. Direct repair of the defect may be utilized in young adult patients without significant disc degeneration and lumbar instability. We used minimally invasive techniques to place pars interarticularis screws with the use of an intraoperative CT scanner in three young adults, including two athletes. This technique is a modification of the original procedure in 1970 by Buck, and it offers the advantage of minimal muscle dissection and optimal screw trajectory. There were no intra- or postoperative complications. The detailed operative procedure and the postoperative course along with a brief review of pars interarticularis defect treatment are discussed.

  8. Flora das cangas da Serra dos Carajás, Pará, Brasil: Lentibulariaceae

    OpenAIRE

    Mota, Nara Furtado de Oliveira; Zappi, Daniela Cristina

    2018-01-01

    Resumo Este estudo compreende as espécies de Lentibulariaceae que ocorrem sobre canga na Serra dos Carajás, estado do Pará, Brasil, incluindo chaves de identificação, descrições detalhadas, ilustrações e comentários morfológicos das espécies. Foram registradas 12 espécies distribuídas em dois gêneros, Genlisea (uma espécie) e Utricularia (11 spp.). Abstract The present study comprises the specis of Lentibulariaceae that occur on iron-stone outcrops (canga) at the Serra dos Carajás, Pará, B...

  9. Enseignement technique/Technical Training

    CERN Multimedia

    1998-01-01

    Matériaux et conception mécanique/Materials & Mechanical Design - Conception assistée par ordinateur/Computer-Aided Design - AutoCAD13/ANSYS 5.4 - EUCLID - CODAP - Technologies spéciales/Special Technologies

  10. L'apprentissage informatique dans les écoles de la Colombie | IDRC ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    8 févr. 2011 ... Pour minimiser les coûts — environ 60 $US par ordinateur — les étudiants du SENA (Servicio Nacional de Aprendizaje) sont tenus de consacrer tout un semestre à la remise en état ... Strengthening Social and Ecological Adaptive Capacity to Climate Change in the Orotoy Watershed, Colombia.

  11. Apprentissage numérique en vue du développement en Asie (DL4D ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    apprentissage numériques, l'enseignement intelligemment assisté par ordinateur et les cours en ligne ouverts à tous constituent une occasion unique d'améliorer la qualité de l'éducation de façon économique et à grande échelle. Le Projet ...

  12. An Application of Didactic Criteria to Courseware Evaluation.

    Science.gov (United States)

    Decoo, Wilfried

    1984-01-01

    Combines a software review with a suggestion for a format that will allow a fair comparison between similar software packages and will also be more complete, accurate, and meaningful to the potential user of the software. The software package "Le Francais Par Ordinateur" is reviewed by this method. (SED)

  13. Résultats de recherche | Page 438 | CRDI - Centre de recherches ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Les lieux d'accès public, notamment les cafés Internet urbains et les télécentres ruraux dirigés par l'État, constituent un point de rassemblement où l'on peut se servir d'un ordinateur et naviguer sur Internet. Publication Date. 1 juin 2015. Livres.

  14. Une proposition de nouveau cartogramme

    Directory of Open Access Journals (Sweden)

    Raymond Badel

    1990-05-01

    Full Text Available Le cartogramme proposé est une technique de recherche-exploration rapide grâce aux possibilités offertes par le micro-ordinateur et sa diffusion. La propriété foncière en vallée d'Aure lui sert de support.

  15. Hypercard au service de l'enseignement de la géographie

    Directory of Open Access Journals (Sweden)

    Denis ECKERT

    1994-03-01

    Full Text Available Un outil d’Enseignement Assisté par Ordinateur (EAO conçu en partant des besoins et des situations réelles des élèves et des enseignants propose, sous Hypercard, des mini-atlas pédagogiques dans un environnement convivial.

  16. Technologies omniprésentes et accès au savoir (A2K) | IDRC ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    De fait, ces appareils viennent remplir les promesses d'initiatives comme " Un ordinateur portable par enfant " (OLPC), qui n'ont jamais vraiment livré les résultats attendus. En Chine, les fabricants de matériel informatique inventent des appareils technologiques ou en remanient pour en créer de nouveaux, dont le statut ...

  17. Résultats de recherche | Page 437 | CRDI - Centre de recherches ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Les lieux d'accès public, notamment les cafés Internet urbains et les télécentres ruraux dirigés par l'État, constituent un point de rassemblement où l'on peut se servir d'un ordinateur et naviguer sur Internet. Publication Date. 1 juin 2015. Livres ...

  18. Un projet de recherche subventionné par le CRDI souligne l ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    29 juil. 2016 ... La modélisation mathématique éclaire les politiques de prévention du VIH en Chine. Un projet de recherche financé par le CRDI utilise la modélisation mathématique pour influer sur les politiques locales et nationales de réduct. Voir davantageLa modélisation mathématique éclaire les politiques de ...

  19. Caractérisation des discontinuités-images par l\\'approche de ...

    African Journals Online (AJOL)

    Les paramètres de texture retenus sont reformulés aux ordres n>2, à partir de leurs différentes formulations mathématiques classiques à l\\'ordre 2, basées sur les matrices de co-occurrences des niveaux de gris. La particularité de cette approche réside dans le fait que chaque pixel est entièrement caractérisé par son ...

  20. Approche numérique de la plasticité induite par transformation ...

    African Journals Online (AJOL)

    H. Hoang et al. 80. Approche numérique de la plasticité induite par transformation diffusionnelle : investigations dans le cas de l'interaction plasticité classique TRIP. Ha Hoang ... d'une phase parente pré-écrouie, d'après ce qu'ont montré Taleb et Petit-Grostabussiat. Ceci a ...... Transformations in Ferrous Alloys : Some.

  1. El domicilio de Bolívar en París

    Directory of Open Access Journals (Sweden)

    Uriel Ospina

    1962-06-01

    Es una calle como tantas en París o como tantas que van a asomarse a sus grandes avenidas, que tienen un cinematógrafo, agencias de turismo, en las esquinas cuatro cafés con sus aceras llenas de mesas y algunos viejos inmuebles con sus clásicas viejas puertas cocheras en una de cuyas alas se abre una puertecita que sirve de entrada a los inquilinos.

  2. 99 Modélisation de la pollution par les nitrates de la nappe de ...

    African Journals Online (AJOL)

    AKA BOKO

    La nappe de Berrechid a toujours suscité un intérêt particulier en tant qu'une source principale d'irrigation et d'alimentation en eau potable dans la région. Cependant, de nombreux indices indiquent une dégradation de la qualité de son eau, contaminée, notamment par les nitrates dont la concentration est excessive.

  3. L'analyse par activation de neutrons de réacteur

    Science.gov (United States)

    Meyer, G.

    2003-02-01

    Quand les neutrons traversent la matière, certains sont transmis sans interaction, les autres interagissent avec le milieu traversé par diffusion et par absorption. Ce phénomène d'absorption est utilisé pour se protéger des neutrons, mais aussi pour les détecter; il peut également être utilisé pour identifier les noyaux “absorbants" et ainsi analyser le milieu traversé. En effet par différentes réactions nucléaires (n,γ), (n,p), (n,α), (n,fission), on obtient des noyaux résiduels qui sont souvent radioactifs; on dit que l'échantillon est “activé". Si l'on connaît le rendement d'activation et donc le pourcentage de noyaux ainsi “transmutés", les mesures de radioactivité induite vont permettre de déterminer la composition de l'échantillon irradié. Cette méthode dite d'analyse par activation neutronique est pratiquée depuis la découverte du neutron. Elle a permis grâce à sa sélectivité et à sa sensibilité d'avoir accès au domaine des traces et des ultra-traces dans des champs d'application très divers comme la métallurgie, l'archéologie, la biologie, la géochimie etc...

  4. Magnétométrie à hélium par pompage laser: le bilan

    Science.gov (United States)

    Gilles, H.; Hamel, J.; Monfort, Y.

    2002-06-01

    Depuis 1986, l'équipe Physique Atomique et Capteurs du CIRIL-ISMRA de Caen étudie les magnétomètres à hélium par pompage laser. On présente ici le bilan de ces travaux de recherche et les performances des deux prototypes (hélium4 et hélium3) réalisés au Laboratoire.

  5. Influence de la substitution graduelle de tourteau de soja par la ...

    African Journals Online (AJOL)

    Objectif: Le présent travail a été entrepris pour déterminer l'influence de la substitution graduelle de tourteau de soja par la féverole sur la croissance et la conformation de la carcasse chez les poulets de chair. Méthodologie et résultats: Notre essai a été porté sur 50 poussins de souche ISA repartis en 05 lots homogènes ...

  6. Etat des lieux et profil de l'imagerie par resonance magnetique dans ...

    African Journals Online (AJOL)

    Objectif: Faire l'état des lieux de la prescription de l'Imagerie par Résonance Magnétique (IRM) et de décrire les aspects IRM des cancers de la prostate au Togo. Matériel et Méthode: Etude rétrospective, descriptive des IRM prostatiques dans le service de radiologie de la clinique Autel d'ELIE sur une période de 5 ans.

  7. Piqures massives par un essaim d�abeilles chez un enfant

    Directory of Open Access Journals (Sweden)

    Mohamed Adnane Berdai

    2011-10-01

    Full Text Available Les piqures multiples d�abeilles sont responsables d�envenimation severe. Nous rapportons un cas d�une attaque massive par un essaim d�abeilles chez un enfant de sept ans. Sa gravite est liee a la localisation cephalique et au nombre important des piqures qui etait d�environ 270. Ses complications etaient l�insuffisance renale, l�anemie et une conjonctivite. La prise en charge etait symptomatique avec bonne evolution clinique et biologique.

  8. Substitution de la farine de ble par la farine fermentee de manioc ...

    African Journals Online (AJOL)

    Il s'agit de substituer une partie de la farine de blé par la farine fermentée du manioc, lafu pour donner une valeur ajoutée aux racines de manioc. Les statistiques de la FAO en 1998 montrent que l'Afrique dépasse tous les autres continents en matière de production et de la qualité du manioc. Face au prix de la farine de blé ...

  9. Effet de l'alimentation calcique séparée sur les performances de ...

    African Journals Online (AJOL)

    SARAH

    31 janv. 2016 ... RÉSUMÉ. Object : L'étude envisagée, se propose de vérifier la réponse de la souche Lhoman Brown soumise à l'alimentation calcique séparée. Elle s'inscrit dans le contexte de la sécurité alimentaire, la lutte contre la pauvreté et les changements climatiques sous climat tropical humide. Matériels et ...

  10. juin 2017 Pendent le dernier trimestre, nous nous sommes préparés ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Angela Wadeyua

    réaction rapide et l'altruisme ont permis de sauver le pays d'une épidémie catastrophique d'Ebola. Découvrez comment un programme de leadership stimulant mis sur pied par l'Université du Cap aide de jeunes chefs de file des secteurs public et privé en Afrique à utiliser le dialogue et le réseautage pour favoriser le ...

  11. Traitement de la margine brute d'huile d'olive par distillation suivi de ...

    African Journals Online (AJOL)

    L'analyse physico-chimique de la margine brute et distillat, montre que ce dernier se caractérise par des abattements très remarquables des composés phénoliques (97%), Demande Chimique en Oxygène (DOC) (92%), Demande Biologique en Oxygène (DBO) (96%), conductivité (99%,) et chlorures (97%). Conclusion et ...

  12. L'urétroplastie par résection anastomose terminoterminale pour ...

    African Journals Online (AJOL)

    K.H. Sikpa

    Résumé. Objectif : évaluer l'uretroplastie par résection anastomose terminoterminale (URAT) au CHU Sylvanus. Olympio de Lomé au Togo. Patients et méthodes : étude descriptive, rétrospective sur 30 mois, portant sur 34 patients qui ont subi une. URAT. Résultats : L'âge moyen des patients était de 44,79+/-15 ans.

  13. Comparative study of 25- versus 20-gauge pars plana capsulotomy and vitrectomy in pediatric cataract surgery.

    Science.gov (United States)

    Rastogi, Anju; Mishra, Manisha; Goel, Yashpal; Thacker, Prolima; Kamlesh

    2018-02-01

    To compare 25- and 20-gauge pars plana vitrectomy (PPV) for the management of pediatric cataract. 20 eyes of 15 patients were randomly divided into two groups to undergo pars plana capsulotomy and vitrectomy by either 25-gauge (group A) or 20-gauge (group B) PPV after lens aspiration and IOL implantation. The two groups were compared for total surgical time, time taken in doing pars plana capsulotomy and vitrectomy, and the size of posterior capsulotomy. Post-operative astigmatism was compared at 3 months. The mean total surgical time in group A was 49.2 ± 6.7 min, while mean total surgical time in group B was 62.5 + 5.48 min (p = 0.001). The mean time taken for pars plana capsulotomy and vitrectomy was 4.1 ± 1.19 min in group A and 5.0 ± 0.73 min (p = 0.03) in group B. The mean size of the PCCC in group A was 3.3 ± 0.34 mm, while in group B it was 4.0 ± 0.33 mm (p = 0.001). The mean astigmatism at 3 months in group A was 0.65 ± 0.31 diopters, while in group B it was 1.45 ± 0.92 diopters (p = 0.019). 25-gauge transconjunctival sutureless PPV can be an attractive alternative to 20-gauge system in the management of pediatric cataracts.

  14. TWENTY-FIVE-GAUGE PARS PLANA VITRECTOMY IN COMPLEX RETINAL DETACHMENTS ASSOCIATED WITH GIANT RETINAL TEAR.

    Science.gov (United States)

    Kumar, Vinod; Kumawat, Devesh; Bhari, Anju; Chandra, Parijat

    2018-04-01

    To study the structural and functional outcomes of 25-gauge pars plana vitrectomy in giant retinal tear-associated retinal detachments. Seventeen eyes of 17 patients with giant retinal tear, who underwent 25-gauge pars plana vitrectomy over a period of 15 months at a tertiary eye care center by a single surgeon, were recruited in this retrospective interventional study. Giant retinal tears were mostly traumatic (35.3%) or associated with myopia (35.3%) and occurred in young (mean age 25.7 years) males (94.1%). Most eyes had best-corrected visual acuity ≤20/1,200 (in 82.3%), foveal detachment (in 88.2%), and proliferative vitreoretinopathy ≤Grade B (in 82.3%). The giant retinal tear extent was more than 180° in 29.4% and the fellow eye was involved in 35.2% of eyes. All eyes underwent 25-gauge pars plana vitrectomy with encircling band in 41.1%, perfluorocarbon liquid use in 82.3%, and endotamponade with sulphur hexafluoride (23.6%) or silicone oil (76.4%). At mean follow-up of 10.2 months, reattachment rate was 88.2%. Only 35.2% of eyes achieved final visual acuity ≥20/80 with a cause of poor vision being cataract, secondary glaucoma, macular pucker, and corneal edema. Twenty-five-gauge pars plana vitrectomy can achieve excellent attachment rates in eyes with giant retinal tear-associated retinal detachment. It can be as efficient as larger-gauge vitrectomy, at the same time retaining all advantages of smaller-gauge surgery.

  15. Corneal ectasia secondary to peripheral endotheliopathy in a patient with classic pars planitis

    OpenAIRE

    Arellanes-Garcia, Lourdes; Preciado-Delgadillo, Maricarmen; Hernandez-Quintela, Everardo; Garza-Leon, Manuel

    2010-01-01

    Purpose To report a case of corneal ectasia secondary to pars planitis corneal endotheliopathy Methods Clinical case description and proposed hypothesis regarding development of corneal ectasia Results Eight-year-old male presented with 360° peripheral corneal endotheliopathy and edema, granulomatous keratic precipitates, and mild iritis OD. A progressive corneal ectasia then developed. Twenty months later, OS presented similarly and anterior chamber inflammatory cells, vitreous snowballs, an...

  16. Octroi de subventions par voie de concours pour l'innovation ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Lors de la première phase du projet (no 102237), les responsables du Fonds régional d'innovation numérique de l'Amérique latine et des Caraïbes (FRIDA) ont reçu 479 propositions dans le cadre des deux appels qu'ils ont organisés et ont financé 26 projets de recherche menés par des établissements de 13 pays.

  17. La participation des femmes à la vie politique se traduit par des ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    La participation des femmes à la vie politique se traduit par des économies locales plus vigoureuses. 08 juin 2016. Image. Des femmes assistent à une réunion d'un groupe d'entraide près d'. Edgard Rodriguez - IDRC. Des femmes assistent à une réunion d'un groupe d'entraide près d'Hyderabad, en Inde. Keenara ...

  18. Évaluation des risques posés par les tanneries à Oulan-Bator ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Cette subvention permettra à l'équipe de recherche de recueillir des données probantes sur la répartition dans l'environnement des polluants chimiques dégagés par les activités des tanneries du district de Khan-Uul, à Oulan-Bator, et sur l'exposition de la population à ces contaminants. Les membres de l'équipe ...

  19. 102 La décoloration des rejets liquides de textile (noir de soufre) par ...

    African Journals Online (AJOL)

    pc

    Dans cette étude, nous nous intéressons au traitement d'un rejet de coloration de textile par voie électrochimique. Les paramètres qui ont ... Ce sujet est particulièrement critique au Maroc, étant donné que l'industrie textile se trouve en ... standards pour examen des eaux et eaux usées [13]. L'analyse du colorant poudre ...

  20. Influence des herbicides sur l'infestation par les adventices, la ...

    African Journals Online (AJOL)

    SARAH

    30 juin 2015 ... Keywords: Wheat, herbicides, weed, density, dry matter. INTRODUCTION. Une des raisons majeures de la chute des rendements des cultures céréalières comme les blés dans la zone «non chernozem» de la Russie et le reste du monde, demeure une forte infestation par différentes espèces adventices.

  1. Compression des signaux EMG par la Transformée dite « impaire ...

    African Journals Online (AJOL)

    Le problème étudié dans cet article est la compression de données des signaux ElectroMyographiques (EMG) par la Transformée dite « impaire ». Cette nouvelle méthode est la version du Lifting Scheme Modifié. La technique utilisée est celle d\\'un sous-échantillonnage des signaux d\\'indices pair et impair. La réduction ...

  2. A minimally invasive approach to defects of the pars interarticularis: Restoring function in competitive athletes.

    Science.gov (United States)

    Gillis, Christopher C; Eichholz, Kurt; Thoman, William J; Fessler, Richard G

    2015-12-01

    To understand that young athletes have a higher incidence of pars interarticularis defects than the general population. This may be due to an immature spine put under higher stress loads at an early age. Traditionally, surgery was reserved for those who failed conservative therapy, and consisted of open exposure, bone grafting and placement of pedicle screws. This leads to a long recovery period and limited ability to return to competitive sport. Four collegiate and professional level athletes, three high school athletes, and one member of the National Guard presented with back pain from spondylolysis without spondylolisthesis. All underwent minimally invasive surgery (MIS) to directly repair the pars defect, for a total of sixteen pars defects repaired in eight patients. Described is an application of a MIS pars repair technique that has not previously been reported, which recreates the normal anatomy rather fusing across a motion segment. Five patients were discharged the day following surgery and three were discharged on postoperative day 2. Six of the patients returned to their previous level of competitiveness. Two were unable to achieve the same level of play, both of whom failed to fuse the spondylolysis. Patients all initially reported clinical improvement postoperatively and there was overall mean improvement on patient reported outcome measures (SF36 physical and mental component scores, visual analog scale, and Oswestry disability index). MIS advantages include less muscle tissue disruption and restoration of the natural anatomy. This leads to a more rapid recovery, decreased perioperative pain, minimal blood loss, earlier mobilization and decreased hospital length of stay. Overall this allows the athlete to start therapy earlier and return to competition sooner and at his/her pre-operative competitive level. The described MIS repair technique outcomes are similar to those that have been reported in the literature and have allowed a high rate of return

  3. Éviter la reprise des conflits par des règlements politiques inclusifs ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Éviter la reprise des conflits par des règlements politiques inclusifs. Les États ayant réussi à s'extraire de la violence et à ... Country(s). Colombia, South America, Far East Asia, Indonesia, Nepal, Sudan, El Salvador, North and Central America, South Africa, North of Sahara, South of Sahara, Central Asia, South Asia ...

  4. Amélioration de la nutrition en Éthiopie par le truchement de la ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Amélioration de la nutrition en Éthiopie par le truchement de la sélection végétale et de la gestion des sols (FCRSAI). L'Éthiopie présente l'un des plus hauts taux de malnutrition au monde. La situation est particulièrement grave dans le sud du pays en raison de la faible productivité agricole et du régime alimentaire ...

  5. 5 - La convergence réelle dans l'espace UEMOA : une approche par ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    CERF

    9 déc. 2009 ... la présence de beta-convergence et l'absence de sigma convergence durant la période 1994-1999 pourraient s'expliquer par l'existence au sein de l'Union des chocs régionaux asymétriques. Si des chocs régionaux asymétriques de grande ampleur interviennent, la dispersion des Produits Intérieurs ...

  6. Utilisation du partographe modifie de l'oms par les sages-femmes ...

    African Journals Online (AJOL)

    ) de l'OMS par les sages-femmes de Lomé et leur position face à cet outil de surveillance du travail. Matériel et méthode : Il s'agit d'une étude prospective, transversale descriptive, menée du 01er juillet au 30 septembre 2011 (soit une période ...

  7. Contamination des eaux de puits traditionnels par les nitrates sur le ...

    African Journals Online (AJOL)

    SARAH

    30 juin 2014 ... Objectif : La contamination des eaux souterraines par les nitrates est un problème réel de santé publique qui fait actuellement l'objet d'une attention particulière dans le monde ..... contenues dans les bases de données écologiques. (Brosse et al 1999a, b et c ; Brosse et al 2001 ;. Giraudel et Lek, 2001 ...

  8. Soutien des activités de recherche par le truchement de l'Initiative ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    26 sept. 2014 ... Ces fonds visent à soutenir les efforts déployés par deux institutions bénéficiaires de l'Initiative Thinktank (ITT) pour réaliser leurs objectifs organisationnels à long terme, à savoir l'Instituto Desarrollo, Participación y Ciudadanía (Instituto Desarrollo) et le Centro de Análisis y Difusión de la Economía ...

  9. Optimisation de la production d'éthanol par les techniques d ...

    African Journals Online (AJOL)

    Nous avons évalué les paramètres optimum pour la production d'alcool à partir de l'efficacité d'hydrolyse de l'amidon: chimique (HCl), enzymatique (amylase de Aspergillus niger ou de malt) et mixte (chimique et enzymatique). La fermentation alcoolique par la levure de bière est suivie, à travers l'influence du pH, de la ...

  10. CALiPER Application Summary Report 20. LED PAR38 Lamps

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2012-11-01

    This report analyzes the independently tested photometric performance of 38 LED PAR38 lamps. The test results indicate substantial improvement versus earlier CALiPER testing of similar products, and performance comparable to recent data from LED Lighting Facts and ENERGY STAR. Additional testing that focuses on performance attributes beyond those covered by LM-79-08 is planned for this group of lamps, and will be presented in subsequent reports.

  11. 184 Évaluation du niveau de pollution par les métaux lourds des ...

    African Journals Online (AJOL)

    Afrique Sciences

    La présente étude a pour objectif principal d'évaluer le niveau de pollution métallique des lacs Bini et Dang. (Ngaoundéré, Cameroun) à travers l'analyse des eaux et des sédiments de surface. La concentration des métaux lourds (Ni, Cr, Fe, Pb, Cd, Zn) a été mesurée par spectrophotométrie d'absorption atomique. Des.

  12. Évaluation du niveau de pollution par les métaux lourds des lacs ...

    African Journals Online (AJOL)

    La présente étude a pour objectif principal d'évaluer le niveau de pollution métallique des lacs Bini et Dang (Ngaoundéré, Cameroun) à travers l'analyse des eaux et des sédiments de surface. La concentration des métaux lourds (Ni, Cr, Fe, Pb, Cd, Zn) a été mesurée par spectrophotométrie d'absorption atomique.

  13. Modélisation de la pollution par les nitrates de la nappe de ...

    African Journals Online (AJOL)

    La nappe de Berrechid a toujours suscité un intérêt particulier en tant qu'une source principale d'irrigation et d'alimentation en eau potable dans la région. Cependant, de nombreux indices indiquent une dégradation de la qualité de son eau, contaminée, notamment par les nitrates dont la concentration est excessive.

  14. Renforcement des capacités de recherche grâce au mentorat par ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Ce projet de recherche-action consistera en un programme collaboratif de mentorat par les pairs conçu pour renforcer les capacités de recherche sur les technologies de l'information et de la communication au service du développement dans les pays du Sud. Le programme sera axé sur les compétences requises pour ...

  15. Évolution du taux et de la place des accouchements par césarienne ...

    African Journals Online (AJOL)

    Évolution du taux et de la place des accouchements par césarienne dans un hôpital de district rural du Burkina Faso : Bilan de 12 ans. Ziemlé Clément Méda, Issaka Sombié, Der Adolph Somé, S. Drissa Barro, G. Léon Sawadogo, Sidi Yé, Adama Ouattara, Hervé Hien, Blami Dao ...

  16. Culture et exercice du pouvoir par les femmes dans les sphères de ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Culture et exercice du pouvoir par les femmes dans les sphères de décisions en Afrique de l'Ouest. Cette recherche s'inscrit dans le contexte d'une superposition de deux faits : l'existence d'un arsenal juridique et de dispositions nationales et internationales favorables à une intégration des femmes dans les instances de ...

  17. Asia Research News présente des projets financés par le CRDI ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    18 juin 2014 ... Publication annuelle phare de ResearchSEA, la revue spécialisée Asia Research News met en relief les travaux de recherche novateurs en cours aux quatre coins de l'Asie. Elle s'inscrit d'ailleurs dans les efforts déployés par ResearchSEA pour attirer l'attention du milieu de la recherche et des médias ...

  18. Fait marquant : discussions sur les données ouvertes entamées par ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    14 avr. 2016 ... Activité antérieure – Le CRDI commandite la tenue d'un symposium dans les Caraïbes sur l'impact d'Internet sur la croissance économique. Le symposium commandité par le CRDI, qui a eu lieu à Saint Andrew, en Jamaïque, le 12 mai 2015, a traité de l'impact d'Internet sur la croissance é.

  19. Evaluation de la contamination de quelques produits maraîchers par ...

    African Journals Online (AJOL)

    L'objectif de cette étude est d'évaluer la contamination, de certains légumes produits à Lomé par le cadmium (Cd), le plomb (Pb), le cuivre (Cu), le zinc (Zn) et le fer (Fe). L'étude a eu pour cadre la ville de Lomé. Des échantillons composites de laitue (Lactuca sativa), de carotte (Daucu carota), de beterrave (Beta vulgaris L.) ...

  20. Éviter la reprise des conflits par des règlements politiques inclusifs ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Les États ayant réussi à s'extraire de la violence et à s'engager dans un processus de développement ont souvent commencé par conclure de bons règlements politiques, ou des pactes entre élites. Ceux-ci prennent parfois la forme d'accords de paix ou de coalitions électorales, voire simplement d'ententes non officielles ...

  1. 102 La décoloration des rejets liquides de textile (noir de soufre) par ...

    African Journals Online (AJOL)

    pc

    textile (SEBARIN) à Fès et ceci juste après le procédé de teinture par Noir de soufre. Le colorant employés dans cette unité de coloration s'agit de colorant de Noir de soufre appartenant à une classe largement utilisées en industrie textile, les caractéristiques des colorants que nous avons utilisés sont données dans.

  2. Moniliophthora roreri (Cif y Par) Evans et al. en el cultivo de cacao

    OpenAIRE

    Sánchez Mora, Fernando David; Garcés Fiallos, Felipe Rafael

    2012-01-01

    More than a century, cacao (Theobroma cacao L.) in Ecuador has been an important source of income for farmers and currency for the country, becoming one of the biggest exporters worldwide. Then, gradually lost that status due to the attack of diseases, including moniliasis caused by [Moniliophthora roreri (Cif and Par) Evans et al.]. It can cause damage of up to 80% in production. Currently there is little scientific date information on its occurrence, symptoms, etiology, epidemiology, life c...

  3. Le Sri Lanka mieux préparé aux futurs tsunamis | IDRC ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    9 nov. 2012 ... Les collectivités côtières vulnérables du Sri Lanka sont désormais mieux outillées pour survivre aux tsunamis, cyclones et autres catastrophes naturelles survenant soudainement. Ce degré accru de préparation est le fruit de travaux de recherche financés par le CRDI qui visaient à cerner les meilleurs ...

  4. suPAR remains uninfluenced by surgery in septic patients with bloodstream infection

    Directory of Open Access Journals (Sweden)

    Rabensteiner, Jasmin

    2016-07-01

    Full Text Available Surgical trauma induces activation of the immune system and may cause an increase of inflammatory biomarkers tested postoperatively in septic patients treated for bloodstream infection. The aim of this study was to determine the impact of surgical interventions on the novel sepsis biomarker soluble urokinase plasminogen activator receptor (suPAR and to compare results with those of routine laboratory parameters CRP, PCT, and IL-6 in patients with culture-proven bloodstream infection. Forty-six adult patients with positive blood culture undergoing minor or major surgical intervention were investigated, 12 blood culture positive patients served as control group. Blood was collected 24 hours before and after surgical intervention for determination of the sepsis biomarkers suPAR, CRP, PCT, and IL-6. Within the surgical study cohort, a non-significant increase of suPAR, CRP, and PCT was observed postoperatively ( 0.642; 0.773; 0.087. In contrast, a slight decrease of IL-6 ( 0.599 was observed. A significant correlation was calculated for the pre- and postoperative difference of CRP ( 0.028 and PCT and type of surgical intervention received: after minor surgical intervention only PCT decreased significantly (<0.001, while after major surgical interventions no significant differences were observed for all biomarkers evaluated. In the control group, a significant decrease of CRP ( 0.005 and PCT ( 0.005 was observed. In patients treated adequately for bloodstream infections, postoperative suPAR levels remained uninfluenced of the surgical trauma and might therefore be a reliable parameter for postoperative infectious monitoring. After minor surgical intervention, PCT seems to be the most reliable parameter.

  5. fait Marouf-Art corrigé par auteur Aout09 _2

    African Journals Online (AJOL)

    Administrateur

    à une mauvaise allocation de l'investissement entre les différentes branches prioritaires ainsi qu'à un choix ... gement en capital matériel et la valeur du capital par tête sont nette- ment moins importants que dans les ... Au total, la concentration du capital dans l'industrie lourde a pénalisé les branches industrielles dont la ...

  6. K-Area and Par Pond Sewage Sludge Application Sites Groundwater Monitoring Report

    International Nuclear Information System (INIS)

    Thompson, C.Y.

    1993-04-01

    During fourth quarter 1992, samples from the three monitoring wells at the K-Area site (KSS series) and the three monitoring wells at the Par Pond site (PSS series) were analyzed for constituents required by South Carolina Department of Health and Environmental Control Construction Permit 13, 173 and for other constituents as part of the Savannah River Site (SRS) Groundwater Monitoring Program. This report describes monitoring results that exceeded the final Primary Drinking Water Standards (PDWS) or the SRS flagging criteria. During fourth quarter 1992, no constituents analyzed exceeded the PDWS or the SRS Flag 2 criteria at the K-Area and Par Pond Sewage Sludge Application Sites. In the KSS well series, the field measurement for alkalinity ranged as high as 26 mg/L in well KSS 1D. Alkalinity measurements were zero in the PSS wells. Historical and current water-level elevations at the K-Area and Par Pond Sewage Sludge Application Site indicate that the groundwater flow directions are south to southwest (SRS grid coordinates)

  7. Equine pituitary pars intermedia dysfunction: current perspectives on diagnosis and management

    Directory of Open Access Journals (Sweden)

    Spelta CW

    2015-08-01

    Full Text Available Caroline W Spelta Townsville Vet Clinic, Townsville, QLD, Australia Abstract: Equine pituitary pars intermedia dysfunction (PPID is a neurodegenerative disease of the hypothalamus, resulting in the loss of dopaminergic inhibition of pars intermedia. An oxidative stress injury of unknown etiology has been suggested to initiate the neurodegeneration. While hypertrichosis (formerly known as hirsutism is considered pathognomic for advanced disease, the antemortem diagnosis of subclinical and early disease has continued to prove difficult. Numerous tests have been used with varying sensitivities and specificities. The overnight dexamethasone suppression test, originally documented to have 100% sensitivity and specificity in horses with advanced disease, has proven to be less valuable in identifying early disease. Basal plasma adrenocorticotropin concentrations have improved sensitivity and specificity when sampled during the autumn months, and α-melanocyte-stimulating hormone, while not yet commercially available, shows promise as a sensitive and specific single sample test. Recent advances in our knowledge include the strong association between laminitis and hyperinsulinemia, both common clinical signs associated with PPID. The pathogenesis of hyperinsulinemia, laminitis, and their association with this disease is a focus of current research. The dopamine agonist pergolide mesylate is still the mainstay of medical management, with studies on oral bioavailability, pharmacokinetics, and long-term survival rates now published. Keywords: PPID, ACTH, α-MSH, laminitis, pergolide, hypertrichosis, pars pituitary intermedia dysfunction

  8. CRP and suPAR are differently related to anthropometry and subclinical organ damage.

    Science.gov (United States)

    Lyngbæk, Stig; Sehestedt, Thomas; Marott, Jacob L; Hansen, Tine W; Olsen, Michael H; Andersen, Ove; Linneberg, Allan; Madsbad, Sten; Haugaard, Steen B; Eugen-Olsen, Jesper; Jeppesen, Jørgen

    2013-08-10

    Low-grade inflammation is a marker for cardiovascular disease (CVD). The inflammatory biomarkers C-reactive protein (CRP) and soluble urokinase plasminogen activator receptor (suPAR) independently predict CVD. We tested the hypothesis that these biomarkers reflect different aspects of the inflammation associated with CVD. We studied 2273 subjects without CVD. Log-transformed CRP and suPAR were included in general linear and logistic regression models to compare associations with measures of anthropometry and subclinical organ damage (SOD). Owing to interactions on body mass index (BMI) (Panthropometry. In both genders, independent of smoking, log-CRP was positively associated with BMI (β: 0.28 to 0.40, P3: 1.31 (1.16-1.47), whereas log-CRP was not (1.00 (0.89-1.11))). CRP is positively associated with anthropometric measures, whereas suPAR is linked to endothelial dysfunction and atherosclerosis. Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

  9. Elaboration of fiber-reinforced metallic materials; Elaboration des materiaux metalliques renforces par des fibres

    Energy Technology Data Exchange (ETDEWEB)

    Martin, J.M. [Commissariat a l' Energie Atomique, Grenoble (France). Centre d' Etudes Nucleaires

    1969-08-01

    A bibliographic study on the elaboration of fiber reinforced metallic materials is presented in three parts: the theory of fiber reinforcement of metals in summarized, with emphasis on the mechanical and geometric factors which govern the behaviour and the performances to be expected from a given composite material; a second part is devoted to the study of the physical and chemical factors related to the structural stability of the material. Finally, the various processes of fabrication of such composites are presented and discussed. (author) [French] Cette etude bibliographique de l'elaboration des materiaux metalliques renforces par des fibres, comprend trois parties. Dans la premiere partie, la theorie du renforcement des metaux par des fibres est resumee de maniere a mettre en lumiere les facteurs mecaniques et geometriques qui determinent le comportement et les performances que l'on peut attendre d'un composite donne. La seconde partie est consacree a l'etude des facteurs physico-chimiques qui determinent la stabilite structurale d'un composite. Enfin, la troisieme partie est constituee par l'expose des differentes methodes d'elaboration des composites. (auteur)

  10. Etk/Bmx regulates proteinase-activated-receptor1 (PAR1 in breast cancer invasion: signaling partners, hierarchy and physiological significance.

    Directory of Open Access Journals (Sweden)

    Irit Cohen

    Full Text Available BACKGROUND: While protease-activated-receptor 1 (PAR(1 plays a central role in tumor progression, little is known about the cell signaling involved. METHODOLOGY/PRINCIPAL FINDINGS: We show here the impact of PAR(1 cellular activities using both an orthotopic mouse mammary xenograft and a colorectal-liver metastasis model in vivo, with biochemical analyses in vitro. Large and highly vascularized tumors were generated by cells over-expressing wt hPar1, Y397Z hPar1, with persistent signaling, or Y381A hPar1 mutant constructs. In contrast, cells over-expressing the truncated form of hPar1, which lacks the cytoplasmic tail, developed small or no tumors, similar to cells expressing empty vector or control untreated cells. Antibody array membranes revealed essential hPar1 partners including Etk/Bmx and Shc. PAR(1 activation induces Etk/Bmx and Shc binding to the receptor C-tail to form a complex. Y/A mutations in the PAR(1 C-tail did not prevent Shc-PAR(1 association, but enhanced the number of liver metastases compared with the already increased metastases obtained with wt hPar1. We found that Etk/Bmx first binds via the PH domain to a region of seven residues, located between C378-S384 in PAR(1 C-tail, enabling subsequent Shc association. Importantly, expression of the hPar1-7A mutant form (substituted A, residues 378-384, which is incapable of binding Etk/Bmx, resulted in inhibition of invasion through Matrigel-coated membranes. Similarly, knocking down Etk/Bmx inhibited PAR(1-induced MDA-MB-435 cell migration. In addition, intact spheroid morphogenesis of MCF10A cells is markedly disrupted by the ectopic expression of wt hPar1. In contrast, the forced expression of the hPar1-7A mutant results in normal ball-shaped spheroids. Thus, by preventing binding of Etk/Bmx to PAR(1 -C-tail, hPar1 oncogenic properties are abrogated. CONCLUSIONS/SIGNIFICANCE: This is the first demonstration that a cytoplasmic portion of the PAR(1 C-tail functions as a scaffold

  11. Etude par imagerie radar des pollutions pétrolières

    Directory of Open Access Journals (Sweden)

    G. Rees

    2004-06-01

    Full Text Available En Russie, chaque année, les déversements de pétrole représentent un cinquième de la production totale. Les plus importants se produisent dans le domaine périglaciaire où le milieu naturel est d’une extrême fragilité. Les pipelines sont soumis à de rudes conditions notamment à la corrosion et aux processus cryogéniques. Le risque de rupture augmente en conséquence. La surveillance des déversements d’hydrocarbures, contrainte par l’immensité et la fréquente inaccessibilité du réseau de pipelines, peut être réalisée par le recours à la télédétection. L’objectif de ce travail est de fournir, à travers l’exemple de la catastrophe d’Usinsk (Rép. de Komi survenue en 1994, des outils d’analyse des images radar. Outre leur capacité à s’affranchir du couvert nuageux, les capteurs radar apportent des informations complémentaires à celles fournies par des capteurs optiques. L’exploitation thématique de ces images est rendue difficile par un certain nombre de facteurs perturbateurs tels que les caractéristiques propres du capteur, la direction de visée, la topographie et le phénomène de chatoiement (speckle. Le travail présenté montre le rôle prépondérant joué par ces corrections qui permettent de disposer de données quantitatives comparables d’une date à une autre. La méthode mise au point ici pour le suivi temporel de l’épanchement de pétrole d’Usinsk à partir de trois images radar, est discutée notamment dans ses limites et son aspect opérationnel possible.

  12. MR imaging of lumbar spondylolysis: signal intensity change in the pars interarticularis and adjacent structures

    Energy Technology Data Exchange (ETDEWEB)

    Jang, Suk Whan; Lee, Ghi Jai; Shim, Jae Chan; Kim, Ho Kyun [Inje Univ. College of Medicine, Kimhae (Korea, Republic of)

    2001-05-01

    To assess changes in MR signal intensity in the pars interarticularis and adjacent structures in patients with lumbar spondylolysis. The MR images of 36 patients with lumbar spondylolysis, confirmed by plain radiographs, were retrospectively analyzed. Using a 1.0T unit, we evaluated the signal intensity of a total of 216 parts interarticulares and adjacent structures from L3 to L5, as seen on sagittal images, and differences between areas with and without spondylolysis. The signal intensity of T1-and T2-weighted images was graded 0(more hypointense than spinal body), 1(as isointense as spinal body), 2(more hyperintense than spinal body and more hypointense than epidural fat), or 3(as isointense as epidural fat). Signal intensity change in endplates and degree of spondylolisthesis were analyzed, and the relationship between these factors was determined. Spondylolysis was noted at L5 in 61 cases, at L4 in 22, and of L3 in no case. In three cases spondylolysis was unilateral, and in the remainder it was bilateral. The degree of signal intensity was the same on T1-and T2-weighted images, and no case was grade 0. Eighty-six of 133 areas without spondylolysis were grade 1, 43 were grade 2, and four were grade 3. In 42 of 47 cases, signal intensity change was localized at pedicles. Among 83 areas with spondylolysis,on the other hand, nine were grade 1, 48 were grade 2, and 26 were grade 3. Signal intensity change was most commonly observed at the pars interarticularis, pedicle, and lamina(50/74)({rho}<0.001). Signal intensity change at the pars interarticularis and adjacent structures was accompanied in most cases by degenerative endplate change(10/11) and spondylolisthesis(11/13)({rho}<0.001). In patients with spondylolysis, signal intensity was frequently higher at the pars interarticularis and adjacent structures, and is thought to have a close relationship with degenerative endplate change and spondylolisthesis. Increases in signal intensity at the pars

  13. MR imaging of lumbar spondylolysis: signal intensity change in the pars interarticularis and adjacent structures

    International Nuclear Information System (INIS)

    Jang, Suk Whan; Lee, Ghi Jai; Shim, Jae Chan; Kim, Ho Kyun

    2001-01-01

    To assess changes in MR signal intensity in the pars interarticularis and adjacent structures in patients with lumbar spondylolysis. The MR images of 36 patients with lumbar spondylolysis, confirmed by plain radiographs, were retrospectively analyzed. Using a 1.0T unit, we evaluated the signal intensity of a total of 216 parts interarticulares and adjacent structures from L3 to L5, as seen on sagittal images, and differences between areas with and without spondylolysis. The signal intensity of T1-and T2-weighted images was graded 0(more hypointense than spinal body), 1(as isointense as spinal body), 2(more hyperintense than spinal body and more hypointense than epidural fat), or 3(as isointense as epidural fat). Signal intensity change in endplates and degree of spondylolisthesis were analyzed, and the relationship between these factors was determined. Spondylolysis was noted at L5 in 61 cases, at L4 in 22, and of L3 in no case. In three cases spondylolysis was unilateral, and in the remainder it was bilateral. The degree of signal intensity was the same on T1-and T2-weighted images, and no case was grade 0. Eighty-six of 133 areas without spondylolysis were grade 1, 43 were grade 2, and four were grade 3. In 42 of 47 cases, signal intensity change was localized at pedicles. Among 83 areas with spondylolysis,on the other hand, nine were grade 1, 48 were grade 2, and 26 were grade 3. Signal intensity change was most commonly observed at the pars interarticularis, pedicle, and lamina(50/74)(ρ<0.001). Signal intensity change at the pars interarticularis and adjacent structures was accompanied in most cases by degenerative endplate change(10/11) and spondylolisthesis(11/13)(ρ<0.001). In patients with spondylolysis, signal intensity was frequently higher at the pars interarticularis and adjacent structures, and is thought to have a close relationship with degenerative endplate change and spondylolisthesis. Increases in signal intensity at the pars interarticularis and

  14. uPAR Targeted Radionuclide Therapy with 177Lu-DOTA-AE105 Inhibits Dissemination of Metastatic Prostate Cancer

    DEFF Research Database (Denmark)

    Persson, Morten; Juhl, Karina; Rasmussen, Palle

    2014-01-01

    The urokinase-type plasminogen activator receptor (uPAR) is implicated in cancer invasion and metastatic development in prostate cancer and provides therefore an attractive molecular target for both imaging and therapy. In this study, we provide the first in vivo data on an antimetastatic effect...... of uPAR radionuclide targeted therapy in such lesions and show the potential of uPAR positron emission tomography (PET) imaging for identifying small foci of metastatic cells in a mouse model of disseminating human prostate cancer. Two radiolabeled ligands were generated in high purity and specific...... value of 100 nM in a competitive binding experiment. In vivo, uPAR targeted radionuclide therapy significantly reduced the number of metastatic lesions in the disseminated metastatic prostate cancer model, when compared to vehicle and nontargeted 177Lu groups (p

  15. EARLY SIMULTANEOUS FUNDUS AUTOFLUORESCENCE AND OPTICAL COHERENCE TOMOGRAPHY FEATURES AFTER PARS PLANA VITRECTOMY FOR PRIMARY RHEGMATOGENOUS RETINAL DETACHMENT

    NARCIS (Netherlands)

    Dellʼomo, Roberto; Mura, Marco; Lesnik Oberstein, Sarit Y.; Bijl, Heico; Tan, H. Stevie

    2012-01-01

    Purpose: To describe fundus autofluorescence and optical coherence tomography (OCT) features of the macula after pars plana vitrectomy for rhegmatogenous retinal detachment. Methods: Thirty-three eyes of 33 consecutive patients with repaired rhegmatogenous retinal detachment with or without the

  16. uPAR targeted radionuclide therapy with (177)Lu-DOTA-AE105 inhibits dissemination of metastatic prostate cancer.

    Science.gov (United States)

    Persson, Morten; Juhl, Karina; Rasmussen, Palle; Brandt-Larsen, Malene; Madsen, Jacob; Ploug, Michael; Kjaer, Andreas

    2014-08-04

    The urokinase-type plasminogen activator receptor (uPAR) is implicated in cancer invasion and metastatic development in prostate cancer and provides therefore an attractive molecular target for both imaging and therapy. In this study, we provide the first in vivo data on an antimetastatic effect of uPAR radionuclide targeted therapy in such lesions and show the potential of uPAR positron emission tomography (PET) imaging for identifying small foci of metastatic cells in a mouse model of disseminating human prostate cancer. Two radiolabeled ligands were generated in high purity and specific activity: a uPAR-targeting probe ((177)Lu-DOTA-AE105) and a nonbinding control ((177)Lu-DOTA-AE105mut). Both uPAR flow cytometry and ELISA confirmed high expression levels of the target uPAR in PC-3M-LUC2.luc cells, and cell binding studies using (177)Lu-DOTA-AE105 resulted in a specific binding with an IC50 value of 100 nM in a competitive binding experiment. In vivo, uPAR targeted radionuclide therapy significantly reduced the number of metastatic lesions in the disseminated metastatic prostate cancer model, when compared to vehicle and nontargeted (177)Lu groups (p < 0.05) using bioluminescence imaging. Moreover, we found a significantly longer metastatic-free survival, with 65% of all mice without any disseminated metastatic lesions present at 65 days after first treatment dose (p = 0.047). In contrast, only 30% of all mice in the combined control groups treated with (177)Lu-DOTA-AE105mut or vehicle were without metastatic lesions. No treatment-induced toxicity was observed during the study as evaluated by observing animal weight and H&E staining of kidney tissue (dose-limiting organ). Finally, uPAR PET imaging using (64)Cu-DOTA-AE105 detected all small, disseminated metastatic foci when compared with bioluminescence imaging in a cohort of animals during the treatment study. In conclusion, uPAR targeted radiotherapy resulted in a significant reduction in the number of

  17. TNF-α and IFN-γ Together Up-Regulates Par-4 Expression and Induce Apoptosis in Human Neuroblastomas.

    Science.gov (United States)

    Shelke, Ganesh V; Jagtap, Jayashree C; Kim, Dae-Kyum; Shah, Reecha D; Das, Gowry; Shivayogi, Mruthyunjaya; Pujari, Radha; Shastry, Padma

    2017-12-26

    The objective of this study was to examine the combined effect of Interferon-gamma (IFN-γ) and Tumor Necrosis factor-alpha (TNF-α) on cytotoxicity and expression of prostate apoptosis response-4 (Par-4) and Par-4 interacting proteins B-cell lymphoma (Bcl-2), nuclear factor kappa-light-chain-enhancer of activated B cells/p65 subunit (NF-κB/p65), Ak mouse strain thymoma (Akt) in human neuroblastoma (NB) cells. Materials and methods included human neuroblastoma cell lines-SK-N-MC, SK-N-SH, and SH-SY5Y, which were treated with IFN-γ and TNF-α individually, or in combination, and were assessed for viability by tetrazolium (MTT) assay. Apoptosis was monitored by hypodiploid population (by flow cytometry), DNA fragmentation, Poly (ADP-ribose) polymerase (PARP) cleavage, and caspase-8 activity. Transcript level of Par-4 was measured by RT-PCR. Protein levels of Par-4 and suppressor of cytokine signaling 3 (SOCS-3) were assessed by immunoblotting. Cellular localization of Par-4 and p65 was examined by immunofluorescence. Unbiased transcript analysis for IFN-γ, TNF-α, and Par-4 were analyzed from three independent clinical datasets from neuroblastoma patients. In terms of results, SK-N-MC cells treated with a combination of, but not individually with, IFN-γ and TNF-α induced apoptosis characterized by hypodiploidy, DNA fragmentation, PARP cleavage, and increased caspase-8 activity. Apoptosis was associated with up-regulation of Par-4 mRNA and protein expression. Immunofluorescence studies revealed that Par-4 was localized exclusively in cytoplasm in SK-N-MC cells cultured for 24 h. but showed nuclear localization at 48 h. Treatment with IFN-γ and TNF-α together enhanced the intensity of nuclear Par-4. In gene expression, data from human neuroblastoma patients, levels of IFN-γ, and TNF-α have strong synergy with Par-4 expression and provide good survival advantage. The findings also demonstrated that apoptosis was associated with reduced level of pro

  18. TNF-α and IFN-γ Together Up-Regulates Par-4 Expression and Induce Apoptosis in Human Neuroblastomas

    Directory of Open Access Journals (Sweden)

    Ganesh V. Shelke

    2017-12-01

    Full Text Available The objective of this study was to examine the combined effect of Interferon-gamma (IFN-γ and Tumor Necrosis factor-alpha (TNF-α on cytotoxicity and expression of prostate apoptosis response-4 (Par-4 and Par-4 interacting proteins B-cell lymphoma (Bcl-2, nuclear factor kappa-light-chain-enhancer of activated B cells/p65 subunit (NF-κB/p65, Ak mouse strain thymoma (Akt in human neuroblastoma (NB cells. Materials and methods included human neuroblastoma cell lines-SK-N-MC, SK-N-SH, and SH-SY5Y, which were treated with IFN-γ and TNF-α individually, or in combination, and were assessed for viability by tetrazolium (MTT assay. Apoptosis was monitored by hypodiploid population (by flow cytometry, DNA fragmentation, Poly (ADP-ribose polymerase (PARP cleavage, and caspase-8 activity. Transcript level of Par-4 was measured by RT-PCR. Protein levels of Par-4 and suppressor of cytokine signaling 3 (SOCS-3 were assessed by immunoblotting. Cellular localization of Par-4 and p65 was examined by immunofluorescence. Unbiased transcript analysis for IFN-γ, TNF-α, and Par-4 were analyzed from three independent clinical datasets from neuroblastoma patients. In terms of results, SK-N-MC cells treated with a combination of, but not individually with, IFN-γ and TNF-α induced apoptosis characterized by hypodiploidy, DNA fragmentation, PARP cleavage, and increased caspase-8 activity. Apoptosis was associated with up-regulation of Par-4 mRNA and protein expression. Immunofluorescence studies revealed that Par-4 was localized exclusively in cytoplasm in SK-N-MC cells cultured for 24 h. but showed nuclear localization at 48 h. Treatment with IFN-γ and TNF-α together enhanced the intensity of nuclear Par-4. In gene expression, data from human neuroblastoma patients, levels of IFN-γ, and TNF-α have strong synergy with Par-4 expression and provide good survival advantage. The findings also demonstrated that apoptosis was associated with reduced level of pro

  19. PAR 407

    Indian Academy of Sciences (India)

    Chakraborty A. Response of an ocean general circulation model to wind and thermodynamic forcings. 329. Chakraborty S. Effect of intraband variability on stable isotope and density time series obtained from banded corals. 145. Chattopadhyay Nandini see Mukhopadhyay Dhruba. 21 de Souza S N see Kumar S Prasanna.

  20. EXAME PRÉ-PARTICIPAÇÃO ESPORTIVA E O PAR-Q, EM PRATICANTES DE ACADEMIAS

    Directory of Open Access Journals (Sweden)

    Ingryd Maturo Andreazzi

    Full Text Available RESUMO Introdução: O Brasil tem o maior número de academias do mundo (cerca de 20 mil e aproximadamente de 3,6 milhões de brasileiros praticam atividade física nesses locais. Torna-se necessária uma padronização da triagem de praticantes de academia a fim de reduzir ao máximo o risco de morte súbita e outras morbidades associadas ao exercício físico. Objetivo: Comparar o Questionário de Prontidão para Atividade Física (Physical Activity Readiness Questionnaire, PAR-Q com o exame físico pré-participação esportiva na detecção de risco à saúde em praticantes de academia. Métodos: Estudo transversal, realizado nas cidades de São Bernardo do Campo e Guarulhos, São Paulo, Brasil. Foram avaliados 50 indivíduos, de ambos os sexos, entre 18 e 35 anos que iniciariam atividades físicas. Realizou-se anamnese, exame físico geral e ortopédico, teste de flexibilidade e o PAR-Q. As variáveis quantitativas foram analisadas pela média, desvio padrão e porcentagens. A comparação das variáveis contínuas com distribuição normal foi feita pelo teste t e a comparação das variáveis qualitativas, pelo teste do qui-quadrado ou teste exato de Fisher. Fixou-se em 5% a hipótese de nulidade. Resultados: O PAR-Q foi positivo em 20% dos entrevistados, assemelhando-se aos dados da anamnese, em que 28% relataram alguma doença. O questionário teve associação positiva em indivíduos que faziam uso de medicação (p = 0,001, história familiar de hipertensão arterial sistêmica (p = 0,001 e antecedentes de cirurgia (p = 0,03. Os participantes com PAR-Q positivo tiveram os maiores valores de índice de massa corpórea, pressão arterial sistólica e diastólica, mas a diferença não foi estatisticamente significante. O PAR-Q não foi capaz detectar morbidades clínicas como: asma (8%, dislipidemia (4%, hipotireoidismo (2%, tabagismo (8% e cirurgias prévias (40%. O exame abdominal e cardiopulmonar estava alterado em quatro