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Sample records for genome research facility

  1. Next-Generation Genomics Facility at C-CAMP: Accelerating Genomic Research in India

    Science.gov (United States)

    S, Chandana; Russiachand, Heikham; H, Pradeep; S, Shilpa; M, Ashwini; S, Sahana; B, Jayanth; Atla, Goutham; Jain, Smita; Arunkumar, Nandini; Gowda, Malali

    2014-01-01

    Next-Generation Sequencing (NGS; http://www.genome.gov/12513162) is a recent life-sciences technological revolution that allows scientists to decode genomes or transcriptomes at a much faster rate with a lower cost. Genomic-based studies are in a relatively slow pace in India due to the non-availability of genomics experts, trained personnel and dedicated service providers. Using NGS there is a lot of potential to study India's national diversity (of all kinds). We at the Centre for Cellular and Molecular Platforms (C-CAMP) have launched the Next Generation Genomics Facility (NGGF) to provide genomics service to scientists, to train researchers and also work on national and international genomic projects. We have HiSeq1000 from Illumina and GS-FLX Plus from Roche454. The long reads from GS FLX Plus, and high sequence depth from HiSeq1000, are the best and ideal hybrid approaches for de novo and re-sequencing of genomes and transcriptomes. At our facility, we have sequenced around 70 different organisms comprising of more than 388 genomes and 615 transcriptomes – prokaryotes and eukaryotes (fungi, plants and animals). In addition we have optimized other unique applications such as small RNA (miRNA, siRNA etc), long Mate-pair sequencing (2 to 20 Kb), Coding sequences (Exome), Methylome (ChIP-Seq), Restriction Mapping (RAD-Seq), Human Leukocyte Antigen (HLA) typing, mixed genomes (metagenomes) and target amplicons, etc. Translating DNA sequence data from NGS sequencer into meaningful information is an important exercise. Under NGGF, we have bioinformatics experts and high-end computing resources to dissect NGS data such as genome assembly and annotation, gene expression, target enrichment, variant calling (SSR or SNP), comparative analysis etc. Our services (sequencing and bioinformatics) have been utilized by more than 45 organizations (academia and industry) both within India and outside, resulting several publications in peer-reviewed journals and several genomic

  2. Research Facilities | Wind | NREL

    Science.gov (United States)

    Research Facilities Research Facilities NREL's state-of-the-art wind research facilities at the Research Facilities Photo of five men in hard hards observing the end of a turbine blade while it's being tested. Structural Research Facilities A photo of two people silhouetted against a computer simulation of

  3. Basic Research Firing Facility

    Data.gov (United States)

    Federal Laboratory Consortium — The Basic Research Firing Facility is an indoor ballistic test facility that has recently transitioned from a customer-based facility to a dedicated basic research...

  4. Guide to research facilities

    Energy Technology Data Exchange (ETDEWEB)

    1993-06-01

    This Guide provides information on facilities at US Department of Energy (DOE) and other government laboratories that focus on research and development of energy efficiency and renewable energy technologies. These laboratories have opened these facilities to outside users within the scientific community to encourage cooperation between the laboratories and the private sector. The Guide features two types of facilities: designated user facilities and other research facilities. Designated user facilities are one-of-a-kind DOE facilities that are staffed by personnel with unparalleled expertise and that contain sophisticated equipment. Other research facilities are facilities at DOE and other government laboratories that provide sophisticated equipment, testing areas, or processes that may not be available at private facilities. Each facility listing includes the name and phone number of someone you can call for more information.

  5. Environmental Toxicology Research Facility

    Data.gov (United States)

    Federal Laboratory Consortium — Fully-equipped facilities for environmental toxicology researchThe Environmental Toxicology Research Facility (ETRF) located in Vicksburg, MS provides over 8,200 ft...

  6. High Combustion Research Facility

    Data.gov (United States)

    Federal Laboratory Consortium — At NETL's High-Pressure Combustion Research Facility in Morgantown, WV, researchers can investigate new high-pressure, high-temperature hydrogen turbine combustion...

  7. Genomic research in Eucalyptus.

    Science.gov (United States)

    Poke, Fiona S; Vaillancourt, René E; Potts, Brad M; Reid, James B

    2005-09-01

    Eucalyptus L'Hérit. is a genus comprised of more than 700 species that is of vital importance ecologically to Australia and to the forestry industry world-wide, being grown in plantations for the production of solid wood products as well as pulp for paper. With the sequencing of the genomes of Arabidopsis thaliana and Oryza sativa and the recent completion of the first tree genome sequence, Populus trichocarpa, attention has turned to the current status of genomic research in Eucalyptus. For several eucalypt species, large segregating families have been established, high-resolution genetic maps constructed and large EST databases generated. Collaborative efforts have been initiated for the integration of diverse genomic projects and will provide the framework for future research including exploiting the sequence of the entire eucalypt genome which is currently being sequenced. This review summarises the current position of genomic research in Eucalyptus and discusses the direction of future research.

  8. Epidemiology & Genomics Research Program

    Science.gov (United States)

    The Epidemiology and Genomics Research Program, in the National Cancer Institute's Division of Cancer Control and Population Sciences, funds research in human populations to understand the determinants of cancer occurrence and outcomes.

  9. Geodynamics Research Facility

    Data.gov (United States)

    Federal Laboratory Consortium — This GSL facility has evolved over the last three decades to support survivability and protective structures research. Experimental devices include three gas-driven...

  10. Magnetics Research Facility

    Data.gov (United States)

    Federal Laboratory Consortium — The Magnetics Research Facility houses three Helmholtz coils that generate magnetic fields in three perpendicular directions to balance the earth's magnetic field....

  11. Transonic Experimental Research Facility

    Data.gov (United States)

    Federal Laboratory Consortium — The Transonic Experimental Research Facility evaluates aerodynamics and fluid dynamics of projectiles, smart munitions systems, and sub-munitions dispensing systems;...

  12. Flexible Electronics Research Facility

    Data.gov (United States)

    Federal Laboratory Consortium — The Flexible Electronics Research Facility designs, synthesizes, tests, and fabricates materials and devices compatible with flexible substrates for Army information...

  13. Field Research Facility

    Data.gov (United States)

    Federal Laboratory Consortium — The Field Research Facility (FRF) located in Duck, N.C. was established in 1977 to support the U.S. Army Corps of Engineers' coastal engineering mission. The FRF is...

  14. Concrete Research Facility

    Data.gov (United States)

    Federal Laboratory Consortium — This is a 20,000-sq ft laboratory that supports research on all aspects of concrete and materials technology. The staff of this facility offer wide-ranging expertise...

  15. Frost Effects Research Facility

    Data.gov (United States)

    Federal Laboratory Consortium — Full-scale study in controlled conditionsThe Frost Effects Research Facility (FERF) is the largest refrigerated warehouse in the United States that can be used for a...

  16. Combustion Research Facility

    Data.gov (United States)

    Federal Laboratory Consortium — For more than 30 years The Combustion Research Facility (CRF) has served as a national and international leader in combustion science and technology. The need for a...

  17. Geophysical Research Facility

    Data.gov (United States)

    Federal Laboratory Consortium — The Geophysical Research Facility (GRF) is a 60 ft long × 22 ft wide × 7 ft deep concrete basin at CRREL for fresh or saltwater investigations and can be temperature...

  18. Radiological Research Accelerator Facility

    International Nuclear Information System (INIS)

    Goldhagen, P.; Marino, S.A.; Randers-Pehrson, G.; Hall, E.J.

    1986-01-01

    The Radiological Research Accelerator Facility (RARAF) is based on a 4-MV Van de Graaff accelerator, which can be used to generate a variety of well-characterized radiation beams for research in radiobiology and radiological physics. It is part of the Radiological Research Laboratory (RRL), and its operation is supported as a National Facility by the US Department of Energy. RARAF is available to all potential users on an equal basis, with priorities based on the recommendations of a Scientific Advisory Committee. Facilities and services are provided to users, but the research projects themselves must be supported separately. This chapter presents a brief description of current experiments being carried out at RARAF and of the operation of the Facility from January through June, 1986. Operation of the Facility for all of 1985 was described in the 1985 Progress Report for RARAF. The experiments described here were supported by various Grants and Contracts from NIH and DOE and by the Statens Stralskyddsinstitut of Sweden

  19. National Human Genome Research Institute

    Science.gov (United States)

    ... Care Genomic Medicine Working Group New Horizons and Research Patient Management Policy and Ethics Issues Quick Links for Patient Care Education All About the Human Genome Project Fact Sheets Genetic Education Resources for ...

  20. Genomic research perspectives in Kazakhstan

    Directory of Open Access Journals (Sweden)

    Ainur Akilzhanova

    2014-01-01

    Full Text Available Introduction: Technological advancements rapidly propel the field of genome research. Advances in genetics and genomics such as the sequence of the human genome, the human haplotype map, open access databases, cheaper genotyping and chemical genomics, have transformed basic and translational biomedical research. Several projects in the field of genomic and personalized medicine have been conducted at the Center for Life Sciences in Nazarbayev University. The prioritized areas of research include: genomics of multifactorial diseases, cancer genomics, bioinformatics, genetics of infectious diseases and population genomics. At present, DNA-based risk assessment for common complex diseases, application of molecular signatures for cancer diagnosis and prognosis, genome-guided therapy, and dose selection of therapeutic drugs are the important issues in personalized medicine. Results: To further develop genomic and biomedical projects at Center for Life Sciences, the development of bioinformatics research and infrastructure and the establishment of new collaborations in the field are essential. Widespread use of genetic tools will allow the identification of diseases before the onset of clinical symptoms, the individualization of drug treatment, and could induce individual behavioral changes on the basis of calculated disease risk. However, many challenges remain for the successful translation of genomic knowledge and technologies into health advances, such as medicines and diagnostics. It is important to integrate research and education in the fields of genomics, personalized medicine, and bioinformatics, which will be possible with opening of the new Medical Faculty at Nazarbayev University. People in practice and training need to be educated about the key concepts of genomics and engaged so they can effectively apply their knowledge in a matter that will bring the era of genomic medicine to patient care. This requires the development of well

  1. Shock Thermodynamic Applied Research Facility

    Data.gov (United States)

    Federal Laboratory Consortium — The Shock Thermodynamic Applied Research Facility (STAR) facility, within Sandia’s Solid Dynamic Physics Department, is one of a few institutions in the world with a...

  2. Robotics Research Facility

    Data.gov (United States)

    Federal Laboratory Consortium — This 60 feet x 100 feet structure on the grounds of the Fort Indiantown Gap Pennsylvania National Guard (PNG) Base is a mixed-use facility comprising office space,...

  3. Engine Environment Research Facility (EERF)

    Data.gov (United States)

    Federal Laboratory Consortium — Description: This facility supports research and development testing of the behavior of turbine engine lubricants, fuels and sensors in an actual engine environment....

  4. Materials Engineering Research Facility (MERF)

    Data.gov (United States)

    Federal Laboratory Consortium — Argonne?s Materials Engineering Research Facility (MERF) enables engineers to develop manufacturing processes for producing advanced battery materials in sufficient...

  5. LAMPF: a nuclear research facility

    International Nuclear Information System (INIS)

    Livingston, M.S.

    1977-09-01

    A description is given of the recently completed Los Alamos Meson Physics Facility (LAMPF) which is now taking its place as one of the major installations in this country for the support of research in nuclear science and its applications. Descriptions are given of the organization of the Laboratory, the Users Group, experimental facilities for research and for applications, and procedures for carrying on research studies

  6. Navy Fuel Research Facility

    Data.gov (United States)

    Federal Laboratory Consortium — FUNCTION: Performs basic and applied research to understand the underlying chemistry that impacts the use, handling, and storage of current and future Navy mobility...

  7. Detonation Engine Research Facility (DERF)

    Data.gov (United States)

    Federal Laboratory Consortium — Description: This facility is configured to safely conduct experimental pressuregain combustion research. The DERF is capable of supporting up to 60,000 lbf thrust...

  8. The Radiological Research Accelerator Facility

    International Nuclear Information System (INIS)

    Hall, E.J.; Marino, S.A.

    1990-07-01

    The Radiological Research Accelerator Facility (RARAF) is based on a 4-MV Van de Graaff accelerator, which is used to generate a variety of well-characterized radiation beams for research in radiobiology, radiological physics, and radiation chemistry. It is part of the Center for Radiological Research (CRR) -- formerly the Radiological Research Laboratory (RRL) -- of Columbia University, and its operation is supported as a National Facility by the US Department of Energy (DOE). Fifteen different experiments were run during these 12 months, approximately the same as the previous two years. Brief summaries of each experiment are included. Accelerator usage is summarized and development activities are discussed. 7 refs., 4 tabs

  9. Human Genome Research: Decoding DNA

    Science.gov (United States)

    dropdown arrow Site Map A-Z Index Menu Synopsis Human Genome Research: Decoding DNA Resources with of the DNA double helix during April 2003. James D. Watson, Francis Crick, and Maurice Wilkins were company Celera announced the completion of a "working draft" reference DNA sequence of the human

  10. The Radiological Research Accelerator Facility

    International Nuclear Information System (INIS)

    Hall, E.J.; Marino, S.A.

    1991-05-01

    The Radiological Research Accelerator Facility (RARAF) is based on 4-MV Van de Graaff accelerator, which is used to generate a variety of well-characterized radiation beams for research in radiobiology, radiological physics, and radiation chemistry. It is part of the Center for Radiological Research (CRR) -- formerly the Radiological Research Laboratory (RRL) -- of Columbia University, and its operation is supported as a National Facility by the US Department of Energy (DOE). As such, RARAF is available to all potential users on an equal basis, and scientists outside the CRR are encouraged to submit proposals for experiments at RARAF. The operation of the Van de Graaff is supported by the DOE, but the research projects themselves must be supported separately. Brief summaries of research experiments are included. Accelerator usage is summarized and development activities are discussed. 8 refs., 8 tabs

  11. The INEL Tritium Research Facility

    International Nuclear Information System (INIS)

    Longhurst, G.R.

    1990-01-01

    The Tritium Research Facility (TRF) at the Idaho National Engineering Laboratory (INEL) is a small, multi-user facility dedicated to research into processes and phenomena associated with interaction of hydrogen isotopes with other materials. Focusing on bench-scale experiments, the main objectives include resolution of issues related to tritium safety in fusion reactors and the science and technology pertinent to some of those issues. In this report the TRF and many of its capabilities will be described. Work presently or recently underway there will be discussed, and the implications of that work to the development of fusion energy systems will be considered. (orig.)

  12. The INEL Tritium Research Facility

    Energy Technology Data Exchange (ETDEWEB)

    Longhurst, G.R. (Idaho National Engineering Lab., Idaho Falls (USA))

    1990-06-01

    The Tritium Research Facility (TRF) at the Idaho National Engineering Laboratory (INEL) is a small, multi-user facility dedicated to research into processes and phenomena associated with interaction of hydrogen isotopes with other materials. Focusing on bench-scale experiments, the main objectives include resolution of issues related to tritium safety in fusion reactors and the science and technology pertinent to some of those issues. In this report the TRF and many of its capabilities will be described. Work presently or recently underway there will be discussed, and the implications of that work to the development of fusion energy systems will be considered. (orig.).

  13. The Radiological Research Accelerator Facility

    International Nuclear Information System (INIS)

    Hall, E.J.

    1992-05-01

    The Radiological Research Accelerator Facility (RARAF) is based on a 4-MV Van de Graaff accelerator, which is used to generate a variety of well-characterized radiation beams for research in radiobiology, radiological physics, and radiation chemistry. It is part of the Center for Radiological Research (CRR) -- formerly the Radiological Research Laboratory (RRL) -- of Columbia University, and its operation is supported as a National Facility by the US Department of Energy (DOE). As such, RARAF is available to all potential users on an equal basis, and scientists outside the CRR are encouraged to submit proposals for experiments at RARAF. The operation of the Van de Graaff is supported by the DOE, but the research projects themselves must be supported separately. Experiments performed from May 1991--April 1992 are described

  14. The Radiological Research Accelerator Facility

    International Nuclear Information System (INIS)

    Hall, E.J.; Marino, S.A.

    1993-05-01

    The Radiological Research Accelerator Facility (RARAF) is based on a 4-MV Van de Graaff accelerator, which is used to generate a variety of well-characterized radiation beams for research in radiobiology, radiological physics, and radiation chemistry. It is part of the Center for Radiological Research (CRR) - formerly the Radiological Research Laboratory of Columbia University, and its operation is supported as a National Facility by the US Department of Energy (DOE). As such, RARAF is available to all potential users on an equal basis and scientists outside the CRR are encouraged to submit proposals for experiments at RARAF. The operation of the Van de Graaff is supported by the DOE, but the research projects themselves must be supported separately. This report provides a listing and brief description of experiments performed at RARAF during the May 1, 1992 through April 30, 1993

  15. The Radiological Research Accelerator Facility:

    International Nuclear Information System (INIS)

    Hall, E.J.; Goldhagen, P.

    1988-07-01

    The Radiological Research Accelerator Facility (RARAF) is based on a 4-MV Van de Graaff accelerator, which is used to generated a variety of well-characterized radiation beams for research in radiobiology, radiological physics, and radiation chemistry. It is part of the Radiological Research Laboratory (RRL) of Columbia University, and its operation is supported as a National Facility by the U.S. Department of Energy. As such, RARAF is available to all potential users on an equal basis, and scientists outside the RRL are encouraged to submit proposals for experiments at RARAF. Facilities and services are provided to users, but the research projects themselves must be supported separately. RARAF was located at BNL from 1967 until 1980, when it was dismantled and moved to the Nevis Laboratories of Columbia University, where it was then reassembled and put back into operation. Data obtained from experiment using RARAF have been of pragmatic value to radiation protection and to neutron therapy. At a more fundamental level, the research at RARAF has provided insight into the biological action of radiation and especially its relation to energy distribution in the cell. High-LET radiations are an agent of special importance because they can cause measurable cellular effects by single particles, eliminating some of the complexities of multievent action and more clearly disclosing basic features. This applies particularly to radiation carcinogenesis. Facilities are available at RARAF for exposing objects to different radiations having a wide range of linear energy transfers (LETs)

  16. Development of Bioinformatics Infrastructure for Genomics Research.

    Science.gov (United States)

    Mulder, Nicola J; Adebiyi, Ezekiel; Adebiyi, Marion; Adeyemi, Seun; Ahmed, Azza; Ahmed, Rehab; Akanle, Bola; Alibi, Mohamed; Armstrong, Don L; Aron, Shaun; Ashano, Efejiro; Baichoo, Shakuntala; Benkahla, Alia; Brown, David K; Chimusa, Emile R; Fadlelmola, Faisal M; Falola, Dare; Fatumo, Segun; Ghedira, Kais; Ghouila, Amel; Hazelhurst, Scott; Isewon, Itunuoluwa; Jung, Segun; Kassim, Samar Kamal; Kayondo, Jonathan K; Mbiyavanga, Mamana; Meintjes, Ayton; Mohammed, Somia; Mosaku, Abayomi; Moussa, Ahmed; Muhammd, Mustafa; Mungloo-Dilmohamud, Zahra; Nashiru, Oyekanmi; Odia, Trust; Okafor, Adaobi; Oladipo, Olaleye; Osamor, Victor; Oyelade, Jellili; Sadki, Khalid; Salifu, Samson Pandam; Soyemi, Jumoke; Panji, Sumir; Radouani, Fouzia; Souiai, Oussama; Tastan Bishop, Özlem

    2017-06-01

    Although pockets of bioinformatics excellence have developed in Africa, generally, large-scale genomic data analysis has been limited by the availability of expertise and infrastructure. H3ABioNet, a pan-African bioinformatics network, was established to build capacity specifically to enable H3Africa (Human Heredity and Health in Africa) researchers to analyze their data in Africa. Since the inception of the H3Africa initiative, H3ABioNet's role has evolved in response to changing needs from the consortium and the African bioinformatics community. H3ABioNet set out to develop core bioinformatics infrastructure and capacity for genomics research in various aspects of data collection, transfer, storage, and analysis. Various resources have been developed to address genomic data management and analysis needs of H3Africa researchers and other scientific communities on the continent. NetMap was developed and used to build an accurate picture of network performance within Africa and between Africa and the rest of the world, and Globus Online has been rolled out to facilitate data transfer. A participant recruitment database was developed to monitor participant enrollment, and data is being harmonized through the use of ontologies and controlled vocabularies. The standardized metadata will be integrated to provide a search facility for H3Africa data and biospecimens. Because H3Africa projects are generating large-scale genomic data, facilities for analysis and interpretation are critical. H3ABioNet is implementing several data analysis platforms that provide a large range of bioinformatics tools or workflows, such as Galaxy, the Job Management System, and eBiokits. A set of reproducible, portable, and cloud-scalable pipelines to support the multiple H3Africa data types are also being developed and dockerized to enable execution on multiple computing infrastructures. In addition, new tools have been developed for analysis of the uniquely divergent African data and for

  17. Implementation of genomics research in Africa: challenges and recommendations.

    Science.gov (United States)

    Adebamowo, Sally N; Francis, Veronica; Tambo, Ernest; Diallo, Seybou H; Landouré, Guida; Nembaware, Victoria; Dareng, Eileen; Muhamed, Babu; Odutola, Michael; Akeredolu, Teniola; Nerima, Barbara; Ozumba, Petronilla J; Mbhele, Slee; Ghanash, Anita; Wachinou, Ablo P; Ngomi, Nicholas

    2018-01-01

    There is exponential growth in the interest and implementation of genomics research in Africa. This growth has been facilitated by the Human Hereditary and Health in Africa (H3Africa) initiative, which aims to promote a contemporary research approach to the study of genomics and environmental determinants of common diseases in African populations. The purpose of this article is to describe important challenges affecting genomics research implementation in Africa. The observations, challenges and recommendations presented in this article were obtained through discussions by African scientists at teleconferences and face-to-face meetings, seminars at consortium conferences and in-depth individual discussions. Challenges affecting genomics research implementation in Africa, which are related to limited resources include ill-equipped facilities, poor accessibility to research centers, lack of expertise and an enabling environment for research activities in local hospitals. Challenges related to the research study include delayed funding, extensive procedures and interventions requiring multiple visits, delays setting up research teams and insufficient staff training, language barriers and an underappreciation of cultural norms. While many African countries are struggling to initiate genomics projects, others have set up genomics research facilities that meet international standards. The lessons learned in implementing successful genomics projects in Africa are recommended as strategies to overcome these challenges. These recommendations may guide the development and application of new research programs in low-resource settings.

  18. Implementation of genomics research in Africa: challenges and recommendations

    Science.gov (United States)

    Adebamowo, Sally N.; Francis, Veronica; Tambo, Ernest; Diallo, Seybou H.; Landouré, Guida; Nembaware, Victoria; Dareng, Eileen; Muhamed, Babu; Odutola, Michael; Akeredolu, Teniola; Nerima, Barbara; Ozumba, Petronilla J.; Mbhele, Slee; Ghanash, Anita; Wachinou, Ablo P.; Ngomi, Nicholas

    2018-01-01

    ABSTRACT Background: There is exponential growth in the interest and implementation of genomics research in Africa. This growth has been facilitated by the Human Hereditary and Health in Africa (H3Africa) initiative, which aims to promote a contemporary research approach to the study of genomics and environmental determinants of common diseases in African populations. Objective: The purpose of this article is to describe important challenges affecting genomics research implementation in Africa. Methods: The observations, challenges and recommendations presented in this article were obtained through discussions by African scientists at teleconferences and face-to-face meetings, seminars at consortium conferences and in-depth individual discussions. Results: Challenges affecting genomics research implementation in Africa, which are related to limited resources include ill-equipped facilities, poor accessibility to research centers, lack of expertise and an enabling environment for research activities in local hospitals. Challenges related to the research study include delayed funding, extensive procedures and interventions requiring multiple visits, delays setting up research teams and insufficient staff training, language barriers and an underappreciation of cultural norms. While many African countries are struggling to initiate genomics projects, others have set up genomics research facilities that meet international standards. Conclusions: The lessons learned in implementing successful genomics projects in Africa are recommended as strategies to overcome these challenges. These recommendations may guide the development and application of new research programs in low-resource settings. PMID:29336236

  19. The internationalisation of research facilities

    International Nuclear Information System (INIS)

    Sabine, T.M.

    1999-01-01

    Full text: During the past twenty five years arrangements have been made for sharing the use of major national research facilities amongst the world community of neutron users. The administrative requirements are simple. Scientists are invited to apply for measurement time. The scientific merit of the application is assessed by a committee appointed by the host organisation. If the application is considered to have sufficient merit time is allocated. The only costs to the user are transport and living expenses. These arrangements have advantages for users and for hosts. The user can apply for time on the most suitable instrument. The host in the user country is freed from the responsibility of supplying all instruments. It can specialise in those instruments in which it has particular expertise. The host retains, through its committee, complete control over the use of instruments. The amount of time allocated to international users is dependent on the national demand. The result is efficient use of national facilities. An equally important result is the interaction between members of the international scientific community. Australian scientists routinely use overseas facilities however Australia has refused to join the international group. There is international resentment to this attitude. We have, for example powder diffraction facilities which others wish to use. We have no small-angle scattering facilities and must do our experiments at international centres. I will argue that we should join the international community now. The capacity of the replacement reactor will be far greater than the internal Australian requirements. We will become the natural host for users from countries in the Asian region. To enable us to make a smooth transition to this stage we should immediately advertise an international program for HIFAR

  20. Research facility access & science education

    Energy Technology Data Exchange (ETDEWEB)

    Rosen, S.P. [Univ. of Texas, Arlington, TX (United States); Teplitz, V.L. [Southern Methodist Univ., Dallas, TX (United States). Physics Dept.

    1994-10-01

    As Congress voted to terminate the Superconducting Super Collider (SSC) Laboratory in October of 1993, the Department of Energy was encouraged to maximize the benefits to the nation of approximately $2 billion which had already been expended to date on its evolution. Having been recruited to Texas from other intellectually challenging enclaves around the world, many regional scientists, especially physicists, of course, also began to look for viable ways to preserve some of the potentially short-lived gains made by Texas higher education in anticipation of {open_quotes}the SSC era.{close_quotes} In fact, by November, 1993, approximately 150 physicists and engineers from thirteen Texas universities and the SSC itself, had gathered on the SMU campus to discuss possible re-uses of the SSC assets. Participants at that meeting drew up a petition addressed to the state and federal governments requesting the creation of a joint Texas Facility for Science Education and Research. The idea was to create a facility, open to universities and industry alike, which would preserve the research and development infrastructure and continue the educational mission of the SSC.

  1. Open Access Data Sharing in Genomic Research

    Directory of Open Access Journals (Sweden)

    Stacey Pereira

    2014-08-01

    Full Text Available The current emphasis on broad sharing of human genomic data generated in research in order to maximize utility and public benefit is a significant legacy of the Human Genome Project. Concerns about privacy and discrimination have led to policy responses that restrict access to genomic data as the means for protecting research participants. Our research and experience show, however, that a considerable number of research participants agree to open access sharing of their genomic data when given the choice. General policies that limit access to all genomic data fail to respect the autonomy of these participants and, at the same time, unnecessarily limit the utility of the data. We advocate instead a more balanced approach that allows for individual choice and encourages informed decision making, while protecting against the misuse of genomic data through enhanced legislation.

  2. Stockbridge Antenna Measurement and Research Facility

    Data.gov (United States)

    Federal Laboratory Consortium — The Stockbridge Antenna Measurement Facility is located 23 miles southwest of AFRL¹s Rome Research Site. This unique measurement facility is designed to evaluate the...

  3. Implementing genomics and pharmacogenomics in the clinic: The National Human Genome Research Institute's genomic medicine portfolio.

    Science.gov (United States)

    Manolio, Teri A

    2016-10-01

    Increasing knowledge about the influence of genetic variation on human health and growing availability of reliable, cost-effective genetic testing have spurred the implementation of genomic medicine in the clinic. As defined by the National Human Genome Research Institute (NHGRI), genomic medicine uses an individual's genetic information in his or her clinical care, and has begun to be applied effectively in areas such as cancer genomics, pharmacogenomics, and rare and undiagnosed diseases. In 2011 NHGRI published its strategic vision for the future of genomic research, including an ambitious research agenda to facilitate and promote the implementation of genomic medicine. To realize this agenda, NHGRI is consulting and facilitating collaborations with the external research community through a series of "Genomic Medicine Meetings," under the guidance and leadership of the National Advisory Council on Human Genome Research. These meetings have identified and begun to address significant obstacles to implementation, such as lack of evidence of efficacy, limited availability of genomics expertise and testing, lack of standards, and difficulties in integrating genomic results into electronic medical records. The six research and dissemination initiatives comprising NHGRI's genomic research portfolio are designed to speed the evaluation and incorporation, where appropriate, of genomic technologies and findings into routine clinical care. Actual adoption of successful approaches in clinical care will depend upon the willingness, interest, and energy of professional societies, practitioners, patients, and payers to promote their responsible use and share their experiences in doing so. Published by Elsevier Ireland Ltd.

  4. Genomics Research: World Survey of Public Funding

    Directory of Open Access Journals (Sweden)

    Cook-Deegan Robert M

    2008-10-01

    Full Text Available Abstract Background Over the past two decades, genomics has evolved as a scientific research discipline. Genomics research was fueled initially by government and nonprofit funding sources, later augmented by private research and development (R&D funding. Citizens and taxpayers of many countries have funded much of the research, and have expectations about access to the resulting information and knowledge. While access to knowledge gained from all publicly funded research is desired, access is especially important for fields that have broad social impact and stimulate public dialogue. Genomics is one such field, where public concerns are raised for reasons such as health care and insurance implications, as well as personal and ancestral identification. Thus, genomics has grown rapidly as a field, and attracts considerable interest. Results One way to study the growth of a field of research is to examine its funding. This study focuses on public funding of genomics research, identifying and collecting data from major government and nonprofit organizations around the world, and updating previous estimates of world genomics research funding, including information about geographical origins. We initially identified 89 publicly funded organizations; we requested information about each organization's funding of genomics research. Of these organizations, 48 responded and 34 reported genomics research expenditures (of those that responded but did not supply information, some did not fund such research, others could not quantify it. The figures reported here include all the largest funders and we estimate that we have accounted for most of the genomics research funding from government and nonprofit sources. Conclusion Aggregate spending on genomics research from 34 funding sources averaged around $2.9 billion in 2003 – 2006. The United States spent more than any other country on genomics research, corresponding to 35% of the overall worldwide public

  5. Creating a platform for collaborative genomic research

    Directory of Open Access Journals (Sweden)

    Mark Smithson

    2017-04-01

    The developed genomics informatics platform provides a step-change in this type of genetic research, accelerating reproducible collaborative research across multiple disparate organisations and data sources, of varying type and complexity.

  6. Meson facility. Powerful new research tool

    International Nuclear Information System (INIS)

    Lobashev, V.M.; Tavkhelidze, A.N.

    A meson facility is being built at the Institute of Nuclear Research, USSR Academy of Sciences, in Troitsk, where the Scientific Center, USSR Academy of Sciences is located. The facility will include a linear accelerator for protons and negative hydrogen ions with 600 MeV energy and 0.5-1 mA beam current. Some fundamental studies that can be studied at a meson facility are described in the areas of elementary particles, neutron physics, solid state physics, and applied research. The characteristics of the linear accelerator are given and the meson facility's experimental complex is described

  7. Access to major overseas research facilities

    International Nuclear Information System (INIS)

    Bolderman, J. W.

    1997-01-01

    This paper will describe four schemes which have been established to permit Australian researchers access to some of the most advanced overseas research facilities. These include, access to Major Research Facilities Program, the Australian National Beamline Facility at the Photon Factory, the Australian Synchrotron Research Program and the ISIS Agreement. The details of each of these programs is discussed and the statistics on the scientific output provided. All programs are managed on behalf of the Department of Industry, Science and Tourism by the Australian Nuclear Science and Technology Organisation. One hundred and thirteen senior scientists plus forty, one postgraduate, students were supported through these schemes during the 1996-1997 financial year

  8. Structural Research Facilities | Wind | NREL

    Science.gov (United States)

    -hydraulic equipment and data acquisition systems tailored for researching composite blades and components 61400-23 standard. General types of rotor blade research performed at the NWTC includes: Property

  9. Researches at hadron experiment facility

    International Nuclear Information System (INIS)

    Sawada, Shinya

    2006-01-01

    Some of the nuclear, hadron and elementary particle experiments proposed to hadron experiment facility to use the extracted slow proton beam at J-PARC are overviewed. Characteristic feature of the facility is the secondary beam obtained from the intense proton beam. Nuclear hadron physics experiments and kaon rare decay experiments are presented here as the typical ones. Hypernuclear spectroscopy with S=-2 state is expected to be started as soon as the beam becomes available. The kaon bound systems not only with three nucleons like K-pnn but also more numerous like Li and Be are to be studied systematically. Bound states of two kaons using (K - , K + ) reaction will be challenged. Pentaquark will be searched for and its properties will be studied if it really exists. Nuclear structure studies from the view point of large Bjorken x are planned to be studied by irradiating hydrogen, deuteron or heavier targets with primary proton beam and analyzing generated muon pairs. Properties of vector mesons in nuclear matter are to be studied with the primary beam. Neutral kaon rare decay will be investigated to study CP nonconservation. Large progress of elementary particle physics is anticipated by using the intense proton beam at J-PARC. (S. Funahashi)

  10. Facility management research in the Netherlands

    NARCIS (Netherlands)

    Thijssen, Thomas; van der Voordt, Theo; Mobach, Mark P.

    This article provides a brief overview of the history and development of facility management research in the Netherlands and indicates future directions. Facility management as a profession has developed from single service to multi-services and integral services over the past 15 years.

  11. Flood Fighting Products Research Facility

    Data.gov (United States)

    Federal Laboratory Consortium — A wave research basin at the ERDC Coastal and Hydraulics Laboratory has been modified specifically for testing of temporary, barrier-type, flood fighting products....

  12. Zero Gravity Research Facility (Zero-G)

    Data.gov (United States)

    Federal Laboratory Consortium — The Zero Gravity Research Facility (Zero-G) provides a near weightless or microgravity environment for a duration of 5.18 seconds. This is accomplished by allowing...

  13. Rice Genome Research: Current Status and Future Perspectives

    Directory of Open Access Journals (Sweden)

    Bin Han

    2008-11-01

    Full Text Available Rice ( L. is the leading genomics system among the crop plants. The sequence of the rice genome, the first cereal plant genome, was published in 2005. This review summarizes progress made in rice genome annotations, comparative genomics, and functional genomics researches. It also maps out the status of rice genomics globally and provides a vision of future research directions and resource building.

  14. Access to major overseas research facilities

    Energy Technology Data Exchange (ETDEWEB)

    Bolderman, J. W. [Australian Nuclear Science and Technology Organisation, Lucas Heights, NSW (Australia)

    1997-12-31

    This paper will describe four schemes which have been established to permit Australian researchers access to some of the most advanced overseas research facilities. These include, access to Major Research Facilities Program, the Australian National Beamline Facility at the Photon Factory, the Australian Synchrotron Research Program and the ISIS Agreement. The details of each of these programs is discussed and the statistics on the scientific output provided. All programs are managed on behalf of the Department of Industry, Science and Tourism by the Australian Nuclear Science and Technology Organisation. One hundred and thirteen senior scientists plus forty, one postgraduate, students were supported through these schemes during the 1996-1997 financial year. 1 fig.

  15. The Sanford underground research facility at Homestake

    International Nuclear Information System (INIS)

    Heise, J.

    2014-01-01

    The former Homestake gold mine in Lead, South Dakota is being transformed into a dedicated laboratory to pursue underground research in rare-process physics, as well as offering research opportunities in other disciplines such as biology, geology and engineering. A key component of the Sanford Underground Research Facility (SURF) is the Davis Campus, which is in operation at the 4850-foot level (4300 m.w.e) and currently hosts three projects: the LUX dark matter experiment, the MAJORANA DEMONSTRATOR neutrinoless double-beta decay experiment and the CUBED low-background counter. Plans for possible future experiments at SURF are well underway and include long baseline neutrino oscillation experiments, future dark matter experiments as well as nuclear astrophysics accelerators. Facility upgrades to accommodate some of these future projects have already started. SURF is a dedicated facility with significant expansion capability

  16. Scientist, Single Cell Analysis Facility | Center for Cancer Research

    Science.gov (United States)

    The Cancer Research Technology Program (CRTP) develops and implements emerging technology, cancer biology expertise and research capabilities to accomplish NCI research objectives.  The CRTP is an outward-facing, multi-disciplinary hub purposed to enable the external cancer research community and provides dedicated support to NCI’s intramural Center for Cancer Research (CCR).  The dedicated units provide electron microscopy, protein characterization, protein expression, optical microscopy and nextGen sequencing. These research efforts are an integral part of CCR at the Frederick National Laboratory for Cancer Research (FNLCR).  CRTP scientists also work collaboratively with intramural NCI investigators to provide research technologies and expertise. KEY ROLES AND RESPONSIBILITIES We are seeking a highly motivated Scientist II to join the newly established Single Cell Analysis Facility (SCAF) of the Center for Cancer Research (CCR) at NCI. The SCAF will house state of the art single cell sequencing technologies including 10xGenomics Chromium, BD Genomics Rhapsody, DEPPArray, and other emerging single cell technologies. The Scientist: Will interact with close to 200 laboratories within the CCR to design and carry out single cell experiments for cancer research Will work on single cell isolation/preparation from various tissues and cells and related NexGen sequencing library preparation Is expected to author publications in peer reviewed scientific journals

  17. Genomics-based plant germplasm research (GPGR)

    Institute of Scientific and Technical Information of China (English)

    Jizeng Jia; Hongjie Li; Xueyong Zhang; Zichao Li; Lijuan Qiu

    2017-01-01

    Plant germplasm underpins much of crop genetic improvement. Millions of germplasm accessions have been collected and conserved ex situ and/or in situ, and the major challenge is now how to exploit and utilize this abundant resource. Genomics-based plant germplasm research (GPGR) or "Genoplasmics" is a novel cross-disciplinary research field that seeks to apply the principles and techniques of genomics to germplasm research. We describe in this paper the concept, strategy, and approach behind GPGR, and summarize current progress in the areas of the definition and construction of core collections, enhancement of germplasm with core collections, and gene discovery from core collections. GPGR is opening a new era in germplasm research. The contribution, progress and achievements of GPGR in the future are predicted.

  18. Research activities by INS cyclotron facility

    International Nuclear Information System (INIS)

    1992-06-01

    Research activities made by the cyclotron facility and the related apparatuses at Institute for Nuclear Study (INS), University of Tokyo, have been reviewed in terms of the associated scientific publications. This publication list, which is to be read as a continuation of INS-Rep.-608 (October, 1986), includes experimental works on low-energy nuclear physics, accelerator technology, instrumental developments, radiation physics and other applications in interdisciplinary fields. The publications are classified into the following four categories. (A) : Internal reports published in INS. (B) : Publications in international scientific journals on experimental research works done by the cyclotron facility and the related apparatuses at INS. Those made by outside users are also included. (C) : Publications in international scientific journals on experimental low-energy nuclear physics, which have been done by the staff of INS Nuclear Physics Division using facilities outside INS. (D) : Contributions to international conferences. (author)

  19. Facilities Management research in the Nordic Countries

    DEFF Research Database (Denmark)

    Jensen, Per Anker

    2011-01-01

    to the establishment of the Centre for Facilities Management – Realdania Research (CFM), and updated information from keynote contributions to CFM’s Nordic FM Conference on 22-23 August 2011 by Suvi Nenonen (Finland), Jan Bröchner (Sweden), Geir K Hansen (Norway) and Per Anker Jensen (Denmark)....

  20. CLOUD: an atmospheric research facility at CERN

    OpenAIRE

    The Cloud Collaboration

    2001-01-01

    This report is the second of two addenda to the CLOUD proposal at CERN (physics/0104048), which aims to test experimentally the existence a link between cosmic rays and cloud formation, and to understand the microphysical mechanism. The document places CLOUD in the framework of a CERN facility for atmospheric research, and provides further details on the particle beam requirements.

  1. The Sanford Underground Research Facility at Homestake

    International Nuclear Information System (INIS)

    Heise, J.

    2015-01-01

    The former Homestake gold mine in Lead, South Dakota, has been transformed into a dedicated facility to pursue underground research in rare-process physics, as well as offering research opportunities in other disciplines such as biology, geology and engineering. A key component of the Sanford Underground Research Facility (SURF) is the Davis Campus, which is in operation at the 4850-foot level (4300 m.w.e.) and currently hosts two main physics projects: the LUX dark matter experiment and the MAJORANA DEMONSTRATOR neutrinoless double-beta decay experiment. In addition, two low-background counters currently operate at the Davis Campus in support of current and future experiments. Expansion of the underground laboratory space is underway at the 4850L Ross Campus in order to maintain and enhance low-background assay capabilities as well as to host a unique nuclear astrophysics accelerator facility. Plans to accommodate other future experiments at SURF are also underway and include the next generation of direct-search dark matter experiments and the Fermilab-led international long-baseline neutrino program. Planning to understand the infrastructure developments necessary to accommodate these future projects is well advanced and in some cases have already started. SURF is a dedicated research facility with significant expansion capability

  2. The Sanford Underground Research Facility at Homestake

    International Nuclear Information System (INIS)

    Heise, J

    2015-01-01

    The former Homestakegold mine in Lead, South Dakota has been transformed into a dedicated facility to pursue underground research in rare-process physics, as well as offering research opportunities in other disciplines such as biology, geology and engineering. A key component of the Sanford Underground Research Facility (SURF) is the Davis Campus, which is in operation at the 4850-foot level (4300 m.w.e.) and currently hosts two main physics projects: the LUX dark matter experiment and the MAJORANA DEMONSTRATOR neutrinolessdouble-beta decay experiment. In addition, two low-background counters currently operate at the Davis Campus in support of current and future experiments. Expansion of the underground laboratory space is underway at the 4850L Ross Campus in order to maintain and enhance low- background assay capabilities as well as to host a unique nuclear astrophysics accelerator facility. Plans to accommodate other future experiments at SURF are also underway and include the next generation of direct-search dark matter experiments and the Fermilab-led international long- baseline neutrino program. Planning to understand the infrastructure developments necessary to accommodate these future projects is well advanced and in some cases have already started. SURF is a dedicated research facility with significant expansion capability. (paper)

  3. Unique life sciences research facilities at NASA Ames Research Center

    Science.gov (United States)

    Mulenburg, G. M.; Vasques, M.; Caldwell, W. F.; Tucker, J.

    1994-01-01

    The Life Science Division at NASA's Ames Research Center has a suite of specialized facilities that enable scientists to study the effects of gravity on living systems. This paper describes some of these facilities and their use in research. Seven centrifuges, each with its own unique abilities, allow testing of a variety of parameters on test subjects ranging from single cells through hardware to humans. The Vestibular Research Facility allows the study of both centrifugation and linear acceleration on animals and humans. The Biocomputation Center uses computers for 3D reconstruction of physiological systems, and interactive research tools for virtual reality modeling. Psycophysiological, cardiovascular, exercise physiology, and biomechanical studies are conducted in the 12 bed Human Research Facility and samples are analyzed in the certified Central Clinical Laboratory and other laboratories at Ames. Human bedrest, water immersion and lower body negative pressure equipment are also available to study physiological changes associated with weightlessness. These and other weightlessness models are used in specialized laboratories for the study of basic physiological mechanisms, metabolism and cell biology. Visual-motor performance, perception, and adaptation are studied using ground-based models as well as short term weightlessness experiments (parabolic flights). The unique combination of Life Science research facilities, laboratories, and equipment at Ames Research Center are described in detail in relation to their research contributions.

  4. Holifield Heavy Ion Research Facility: Users handbook

    International Nuclear Information System (INIS)

    Auble, R.L.

    1987-01-01

    The primary objective of this handbook is to provide information for those who plan to carry out research programs at the Holifield Heavy Ion Research Facility (HHIRF) at Oak Ridge National Laboratory. The accelerator systems and experimental apparatus available are described. The mechanism for obtaining accelerator time and the responsibilities of those users who are granted accelerator time are described. The names and phone numbers of ORNL personnel to call for information about specific areas are given

  5. Lewis Research Center R and D Facilities

    Science.gov (United States)

    1991-01-01

    The NASA Lewis Research Center (LeRC) defines and develops advanced technology for high priority national needs. The work of the Center is directed toward new propulsion, power, and communications technologies for application to aeronautics and space, so that U.S. leadership in these areas is ensured. The end product is knowledge, usually in a report, that is made fully available to potential users--the aircraft engine industry, the energy industry, the automotive industry, the space industry, and other NASA centers. In addition to offices and laboratories for almost every kind of physical research in such fields as fluid mechanics, physics, materials, fuels, combustion, thermodynamics, lubrication, heat transfer, and electronics, LeRC has a variety of engineering test cells for experiments with components such as compressors, pumps, conductors, turbines, nozzles, and controls. A number of large facilities can simulate the operating environment for a complete system: altitude chambers for aircraft engines; large supersonic wind tunnels for advanced airframes and propulsion systems; space simulation chambers for electric rockets or spacecraft; and a 420-foot-deep zero-gravity facility for microgravity experiments. Some problems are amenable to detection and solution only in the complete system and at essentially full scale. By combining basic research in pertinent disciplines and generic technologies with applied research on components and complete systems, LeRC has become one of the most productive centers in its field in the world. This brochure describes a number of the facilities that provide LeRC with its exceptional capabilities.

  6. Research and education by SF cyclotron facility

    International Nuclear Information System (INIS)

    1992-04-01

    This report represents the current activities in research and education using the cyclotron facility and related apparatus which are supported by Nuclear Physics Division and this is a continuation of INS-T-466 (1986, December). In this version an iron-free β-ray spectrometer and a cooler-synchrotron (TARN II) are briefly described also in the first chapter. The second chapter explains experimental programs performed in the last 5 years. The third chapter gives the number of publications on researches performed in 1975-1991, and also gives twelve topics obtained from the cyclotron and the β-ray spectrometer in recent 5 years. The last chapter provides the whole list of the works for Doctor and Master theses performed at the facility in the last 10 years. (J.P.N.)

  7. A US Based Ultrafast Interdisciplinary Research Facility

    Science.gov (United States)

    Gueye, Paul; Hill, Wendell; Johnson, Anthony

    2006-10-01

    The US scientific competitiveness on the world arena has substantially decreased due to the lack of funding and training of qualified personnel. Most of the potential workforce found in higher education is composed of foreign students and post-docs. In the specific field of low- and high-field science, the European and Asian communities are rapidly catching-up with the US, even leading in some areas. To remain the leader in ultrafast science and technology, new visions and commitment must be embraced. For that reason, an international effort of more than 70 countries for a US-based interdisciplinary research facility using ultrafast laser technology is under development. It will provide research and educational training, as well as new venues for a strong collaboration between the fields of astrophysics, nuclear/high energy physics, plasma physics, optical sciences, biological and medical physics. This facility will consist of a uniquely designed high contrast multi-lines concept housing twenty experimental rooms shared between four beams:[0.1 TW, 1 kHz], [10 TW, 9 kHz], [100-200 TW, 10 Hz] and [500 TW, 10 Hz]. The detail schematic of this multi-laser system, foreseen research and educational programs, and organizational structure of this facility will be presented.

  8. Operating large controlled thermonuclear fusion research facilities

    International Nuclear Information System (INIS)

    Gaudreau, M.P.J.; Tarrh, J.M.; Post, R.S.; Thomas, P.

    1987-01-01

    The MIT Tara Tandem Mirror is a large, state of the art controlled thermonuclear fusion research facility. Over the six years of its design, implementation, and operation, every effort was made to minimize cost and maximize performance by using the best and latest hardware, software, and scientific and operational techniques. After reviewing all major DOE fusion facilities, an independent DOE review committee concluded that the Tara operation was the most automated and efficient of all DOE facilities. This paper includes a review of the key elements of the Tara design, construction, operation, management, physics milestones, and funding that led to this success. The authors emphasize a chronological description of how the system evolved from the proposal stage to a mature device with an emphasis on the basic philosophies behind the implementation process. This description can serve both as a qualitative and quantitative database for future large experiment planning. It includes actual final costs and manpower spent as well as actual run and maintenance schedules, number of data shots, major system failures, etc. The paper concludes with recommendations for the next generation of facilities

  9. Operating large controlled thermonuclear fusion research facilities

    International Nuclear Information System (INIS)

    Gaudreau, M.P.J.; Tarrh, J.M.; Post, R.S.; Thomas, P.

    1987-10-01

    The MIT Tara Tandem Mirror is a large, state of the art controlled thermonuclear fusion research facility. Over the six years of its design, implementation, and operation, every effort was made to minimize cost and maximize performance by using the best and latest hardware, software, and scientific and operational techniques. After reviewing all major DOE fusion facilities, an independent DOE review committee concluded that the Tara operation was the most automated and efficient of all DOE facilities. This paper includes a review of the key elements of the Tara design, construction, operation, management, physics milestones, and funding that led to this success. We emphasize a chronological description of how the system evolved from the proposal stage to a mature device with an emphasis on the basic philosophies behind the implementation process. This description can serve both as a qualitative and quantitative database for future large experiment planning. It includes actual final costs and manpower spent as well as actual run and maintenance schedules, number of data shots, major system failures, etc. The paper concludes with recommendations for the next generation of facilities. 13 refs., 15 figs., 3 tabs

  10. Experimental facilities for Generation IV reactors research

    International Nuclear Information System (INIS)

    Krecanova, E.; Di Gabriele, F.; Berka, J.; Zychova, M.; Macak, J.; Vojacek, A.

    2013-06-01

    Centrum Vyzkumu Rez (CVR) is research and development Company situated in Czech Republic and member of the UJV group. One of its major fields is material research for Generation IV reactor concepts, especially supercritical water-cooled reactor (SCWR), very high temperature/gas-cooled fast reactor (VHTR/GFR) and lead-cooled fast reactor (LFR). The CVR is equipped by and is building unique experimental facilities which simulate the environment in the active zones of these reactor concepts and enable to pre-qualify and to select proper constructional materials for the most stressed components of the facility (cladding, vessel, piping). New infrastructure is founded within the Sustainable Energy project focused on implementation the Generation IV and fusion experimental facilities. The research of SCWR concept is divided to research and development of the constructional materials ensured by SuperCritical Water Loop (SCWL) and fuel components research on Fuel Qualification Test loop (SCWL-FQT). SCWL provides environment of the primary circuits of European SCWR, pressure 25 MPa, temperature 600 deg. C and its major purpose is to simulate behavior of the primary medium and candidate constructional materials. On-line monitoring system is included to collect the operational data relevant to experiment and its evaluation (pH, conductivity, chemical species concentration). SCWL-FQT is facility focused on the behavior of cladding material and fuel at the conditions of so-called preheater, the first pass of the medium through the fuel (in case of European SCWR concept). The conditions are 450 deg. C and 25 MPa. SCWL-FQT is unique facility enabling research of the shortened fuel rods. VHTR/GFR research covers material testing and also cleaning methods of the medium in primary circuit. The High Temperature Helium Loop (HTHL) enables exposure of materials and simulates the VHTR/GFR core environment to analyze the behavior of medium, especially in presence of organic compounds and

  11. Implementing genomics and pharmacogenomics in the clinic: The National Human Genome Research Institute’s genomic medicine portfolio

    Science.gov (United States)

    Manolio, Teri A.

    2016-01-01

    Increasing knowledge about the influence of genetic variation on human health and growing availability of reliable, cost-effective genetic testing have spurred the implementation of genomic medicine in the clinic. As defined by the National Human Genome Research Institute (NHGRI), genomic medicine uses an individual’s genetic information in his or her clinical care, and has begun to be applied effectively in areas such as cancer genomics, pharmacogenomics, and rare and undiagnosed diseases. In 2011 NHGRI published its strategic vision for the future of genomic research, including an ambitious research agenda to facilitate and promote the implementation of genomic medicine. To realize this agenda, NHGRI is consulting and facilitating collaborations with the external research community through a series of “Genomic Medicine Meetings,” under the guidance and leadership of the National Advisory Council on Human Genome Research. These meetings have identified and begun to address significant obstacles to implementation, such as lack of evidence of efficacy, limited availability of genomics expertise and testing, lack of standards, and diffficulties in integrating genomic results into electronic medical records. The six research and dissemination initiatives comprising NHGRI’s genomic research portfolio are designed to speed the evaluation and incorporation, where appropriate, of genomic technologies and findings into routine clinical care. Actual adoption of successful approaches in clinical care will depend upon the willingness, interest, and energy of professional societies, practitioners, patients, and payers to promote their responsible use and share their experiences in doing so. PMID:27612677

  12. Underground characterisation and research facility ONKALO

    International Nuclear Information System (INIS)

    Ikonen, Antti; Ylae-Mella, Mia; Aeikaes, Timo

    2006-01-01

    Posiva's repository for geological disposal of the spent fuel from Finnish nuclear reactors will be constructed at Olkiluoto. The selection of Olkiluoto was made based on site selection research programme conducted between 1987-2001. The next step is to carry out complementary investigations of the site and apply for the construction license for the disposal facility. The license application will be submitted in 2012. To collect detailed information of the geological environment at planned disposal depth an underground characterisation and research facility will be built at the site. This facility, named as ONKALO, will comprise a spiral access tunnel and two vertical shafts. The excavation of ONKALO is in progress and planned depth (400 m) will be reached in 2009. During the course of the excavation Posiva will conduct site characterisation activities to assess the structure and other properties of the site geology. The aim is that construction will not compromise the favourable conditions of the planned disposal depth or introduce harmful effects in the surrounding bedrock which could jeopardize the long-term safety of the geological disposal. (author)

  13. Holifield Heavy Ion Research Facility. Phase II

    International Nuclear Information System (INIS)

    Ball, J.B.; Hudson, E.D.; Lord, R.S.; Johnson, J.W.; Martin, J.A.; McNeilly, G.S.; Milner, W.T.; Mosko, S.W.; Sayer, R.O.; Robinson, R.L.

    1979-01-01

    The Holifield Heavy Ion Research Facility, with the completion of Phase I in late 1979, will include the Oak Ridge Isochronous Cyclotron (ORIC) and associated research areas, the new 25 MV tandem accelerator with new research areas for tandem beams, and modifications to utilize the ORIC as a booster accelerator. The combination of the tandem and ORIC will provide beam energies of 25 MeV/A for light heavy ions and 6 MeV/A up to A = 160. This paper discusses plans for a Phase II expansion of the facility to include an isochronous cyclotron with superconducting magnet and reconfiguration of the existing research areas and the ORIC vault to handle the higher energy beams from the new cyclotron. The new booster cyclotron is a low-flutter high-spiral design patterned after the MSU K = 800 design, with a central magnetic field of about 5 tesla and an extraction radius of 1 meter. The new beam transport system will incorporate an rf beam-splitter system that will be able to deliver successive beam pulses to two or three experiment areas

  14. Interim Storage Facility for LLW of Decommissioning Nuclear Research Facilities

    Energy Technology Data Exchange (ETDEWEB)

    Amato, S.; Ugolini, D.; Basile, F. [European Commission, Joint Research Centre, Nuclear Decommissioning and Facility Management Unit, TP 800, Via E. Fermi 2749, 21027 Ispra - VA (Italy)

    2009-06-15

    JRC-Ispra has initiated a Decommissioning and Waste Management (D and WM) Programme of all its nuclear facilities. In the frame of this programme, it has been decided to build an interim storage facility to host conditioned low level waste (LLW) that had been produced during the operation of JRC-Ispra nuclear research reactors and laboratories and that will be produced from their decommissioning. This paper presents the main characteristics of the facility. The storage ISFISF has a rectangular shape with uniform height and it is about 128 m long, 41 m wide and 9 m high. The entire surface affected by the facility, including screening area and access roads, is about 27.000 m{sup 2}. It is divided in three sectors, a central one, about 16 m long, for loading/unloading operations and operational services and two lateral sectors, each about 55 m long, for the conditioned LLW storage. Each storage sector is divided by a concrete wall in two transversal compartments. The ISFISF, whose operational lifetime is 50 years, is designed to host the conditioned LLW boxed in UNI CP-5.2 packages, 2,5 m long, 1.65 m wide, and 1,25 m high. The expected nominal inventory of waste is about 2100 packages, while the maximum storage is 2540 packages, thus a considerably large reserve capacity is available. The packages will be piled in stacks of maximum number of five. The LLW is going to be conditioned with a cement matrix. The maximum weight allowed for each package has been fixed at 16.000 kg. The total radioactivity inventory of waste to be hosted in the facility is about 30 TBq (mainly {beta}/{gamma} emitters). In order to satisfy the structural, seismic, and, most of all, radiological requirements, the external walls of the ISFISF are made of pre-fabricated panels, 32 cm thick, consisting of, from inside to outside, 20 cm of reinforced concrete, 7 cm of insulating material, and again 5 cm of reinforced concrete. For the same reason the roof is made with pre-fabricated panels in

  15. Revisiting Respect for Persons in Genomic Research

    Directory of Open Access Journals (Sweden)

    Debra J. H. Mathews

    2014-01-01

    Full Text Available The risks and benefits of research using large databases of personal information are evolving in an era of ubiquitous, internet-based data exchange. In addition, information technology has facilitated a shift in the relationship between individuals and their personal data, enabling increased individual control over how (and how much personal data are used in research, and by whom. This shift in control has created new opportunities to engage members of the public as partners in the research enterprise on more equal and transparent terms. Here, we consider how some of the technological advances driving and paralleling developments in genomics can also be used to supplement the practice of informed consent with other strategies to ensure that the research process as a whole honors the notion of respect for persons upon which human research subjects protections are premised. Further, we suggest that technological advances can help the research enterprise achieve a more thoroughgoing respect for persons than was possible when current policies governing human subject research were developed. Questions remain about the best way to revise policy to accommodate these changes.

  16. ARM Climate Research Facility Annual Report 2005

    Energy Technology Data Exchange (ETDEWEB)

    J. Voyles

    2005-12-31

    Through the ARM Program, the DOE funded the development of several highly instrumented ground stations for studying cloud formation processes and their influence on radiative transfer, and for measuring other parameters that determine the radiative properties of the atmosphere. This scientific infrastructure, and resultant data archive, is a valuable national and international asset for advancing scientific knowledge of Earth systems. In fiscal year (FY) 2003, the DOE designated ARM sites as a national scientific user facility: the ARM Climate Research (ACRF). The ACRF has enormous potential to contribute to a wide range interdisciplinary science in areas such as meteorology, atmospheric aerosols, hydrology, biogeochemical cycling, and satellite validation, to name only a few.

  17. Synchrotron radiation research facility conceptual design report

    International Nuclear Information System (INIS)

    1976-06-01

    A report is presented to define, in general outline, the extent and proportions, the type of construction, the schedule for accomplishment, and the estimated cost for a new Synchrotron Radiation Facility, as proposed to the Energy Research and Development Administration by the Brookhaven National Laboratory. The report is concerned only indirectly with the scientific and technological justification for undertaking this project; the latter is addressed explicitly in separate documents. The report does consider user requirements, however, in order to establish a basis for design development. Preliminary drawings, outline specifications, estimated cost data, and other descriptive material are included as supporting documentation on the current status of the project in this preconstruction phase

  18. SINP MSU accelerator facility and applied research

    International Nuclear Information System (INIS)

    Chechenin, N.G.; Ishkhanov, B.S.; Kulikauskas, V.S.; Novikov, L.S.; Pokhil, G.P.; Romanovskii, E.A.; Shvedunov, V.I.; Spasskii, A.V.

    2004-01-01

    Full text: SINP accelerator facility includes 120 cm cyclotron, electrostatic generator with the upper voltage 3.0 MeV, electrostatic generator with the upper voltage 2.5 MeV, Cocroft -Walton generator with the upper voltage 500 keV, 150 keV accelerator for solid microparticles. A new generation of electron beam accelerators has been developed during the last decade. The SINP accelerator facility will be shortly described in the report. A wide range of basic research in nuclear and atomic physics, physics of ion-beam interactions with condensed matter is currently carried out. SINP activity in the applied research is concentrated in the following areas of materials science: - Materials diagnostics with the Rutherford backscattering techniques (RBS) and channeling of ions (RBS/C). A large number of surface ad-layers and multilayer systems for advanced micro- and nano-electronic technology have been investigated. A selected series of examples will be illustrated. - Concentration depth profiles of hydrogen by the elastic recoils detection techniques (ERD). Primarily, the hydrogen depth profiles in perspective materials for thermonuclear reactors have been investigated. - Lattice site locations of hydrogen by a combination of ERD and channeling techniques. This is a new technique which was successfully applied for investigation of hydrogen and hydrogen-defect complexes in silicon for the smart-cut technology. - Light element diagnostics by RBS and nuclear backscattering techniques (NBS). The technique is illustrated by applications for nitrogen concentration profiling in steels. Nitrogen take-up and release, nitrides precipitate formation will be illustrated. - New medium energy ion scattering (MEIS) facility and applications. Ultra-high vacuum and superior energy resolution electrostatic toroidal analyzer is designed to be applied for characterization of composition and structure of several upper atomic layers of materials

  19. High temperature aircraft research furnace facilities

    Science.gov (United States)

    Smith, James E., Jr.; Cashon, John L.

    1992-01-01

    Focus is on the design, fabrication, and development of the High Temperature Aircraft Research Furnace Facilities (HTARFF). The HTARFF was developed to process electrically conductive materials with high melting points in a low gravity environment. The basic principle of operation is to accurately translate a high temperature arc-plasma gas front as it orbits around a cylindrical sample, thereby making it possible to precisely traverse the entire surface of a sample. The furnace utilizes the gas-tungsten-arc-welding (GTAW) process, also commonly referred to as Tungsten-Inert-Gas (TIG). The HTARFF was developed to further research efforts in the areas of directional solidification, float-zone processing, welding in a low-gravity environment, and segregation effects in metals. The furnace is intended for use aboard the NASA-JSC Reduced Gravity Program KC-135A Aircraft.

  20. How Large-Scale Research Facilities Connect to Global Research

    DEFF Research Database (Denmark)

    Lauto, Giancarlo; Valentin, Finn

    2013-01-01

    Policies for large-scale research facilities (LSRFs) often highlight their spillovers to industrial innovation and their contribution to the external connectivity of the regional innovation system hosting them. Arguably, the particular institutional features of LSRFs are conducive for collaborative...... research. However, based on data on publications produced in 2006–2009 at the Neutron Science Directorate of Oak Ridge National Laboratory in Tennessee (United States), we find that internationalization of its collaborative research is restrained by coordination costs similar to those characterizing other...

  1. A bibliometric analysis of global research on genome sequencing ...

    African Journals Online (AJOL)

    The results show that disease and protein related researches were the leading research focuses, and comparative genomics and evolution related research had strong potential in the near future. Key words: Genome sequencing, research trend, scientometrics, science citation index expanded (SCI-Expanded), word cluster ...

  2. What does it mean to be genomically literate?: National Human Genome Research Institute Meeting Report.

    Science.gov (United States)

    Hurle, Belen; Citrin, Toby; Jenkins, Jean F; Kaphingst, Kimberly A; Lamb, Neil; Roseman, Jo Ellen; Bonham, Vence L

    2013-08-01

    Genomic discoveries will increasingly advance the science of medicine. Limited genomic literacy may adversely impact the public's understanding and use of the power of genetics and genomics in health care and public health. In November 2011, a meeting was held by the National Human Genome Research Institute to examine the challenge of achieving genomic literacy for the general public, from kindergarten to grade 12 to adult education. The role of the media in disseminating scientific messages and in perpetuating or reducing misconceptions was also discussed. Workshop participants agreed that genomic literacy will be achieved only through active engagement between genomics experts and the varied constituencies that comprise the public. This report summarizes the background, content, and outcomes from this meeting, including recommendations for a research agenda to inform decisions about how to advance genomic literacy in our society.

  3. Solar Energy Research Center Instrumentation Facility

    Energy Technology Data Exchange (ETDEWEB)

    Meyer, Thomas, J.; Papanikolas, John, P.

    2011-11-11

    SOLAR ENERGY RESEARCH CENTER INSTRUMENTATION FACILITY The mission of the Solar Energy Research Center (UNC SERC) at the University of North Carolina at Chapel Hill (UNC-CH) is to establish a world leading effort in solar fuels research and to develop the materials and methods needed to fabricate the next generation of solar energy devices. We are addressing the fundamental issues that will drive new strategies for solar energy conversion and the engineering challenges that must be met in order to convert discoveries made in the laboratory into commercially available devices. The development of a photoelectrosynthesis cell (PEC) for solar fuels production faces daunting requirements: (1) Absorb a large fraction of sunlight; (2) Carry out artificial photosynthesis which involves multiple complex reaction steps; (3) Avoid competitive and deleterious side and reverse reactions; (4) Perform 13 million catalytic cycles per year with minimal degradation; (5) Use non-toxic materials; (6) Cost-effectiveness. PEC efficiency is directly determined by the kinetics of each reaction step. The UNC SERC is addressing this challenge by taking a broad interdisciplinary approach in a highly collaborative setting, drawing on expertise across a broad range of disciplines in chemistry, physics and materials science. By taking a systematic approach toward a fundamental understanding of the mechanism of each step, we will be able to gain unique insight and optimize PEC design. Access to cutting-edge spectroscopic tools is critical to this research effort. We have built professionally-staffed facilities equipped with the state-of the-art instrumentation funded by this award. The combination of staff, facilities, and instrumentation specifically tailored for solar fuels research establishes the UNC Solar Energy Research Center Instrumentation Facility as a unique, world-class capability. This congressionally directed project funded the development of two user facilities: TASK 1: SOLAR

  4. Prospects for Genomic Research in Forestry

    Directory of Open Access Journals (Sweden)

    K. V. Krutovsky

    2014-08-01

    Full Text Available Conifers are keystone species of boreal forests. Their whole genome sequencing, assembly and annotation will allow us to understand the evolution of the complex ancient giant conifer genomes that are 4 times larger in larch and 7–9 times larger in pines than the human genome. Genomic studies will allow also to obtain important whole genome sequence data and develop highly polymorphic and informative genetic markers, such as microsatellites and single nucleotide polymorphisms (SNPs that can be efficiently used in timber origin identification, for genetic variation monitoring, to study local and climate change adaptation and in tree improvement and conservation programs.

  5. In Vivo Radiobioassay and Research Facility

    International Nuclear Information System (INIS)

    Lynch, Timothy P.

    2011-01-01

    Bioassay monitoring for intakes of radioactive material is an essential part of the internal dosimetry program for radiation workers at the Department of Energy's (DOE) Hanford Site. This monitoring program includes direct measurements of radionuclides in the body by detecting photons that exit the body and analyses of radionuclides in excreta samples. The specialized equipment and instrumentation required to make the direct measurements of these materials in the body are located at the In Vivo Radiobioassay and Research Facility (IVRRF). The IVRRF was originally built in 1960 and was designed expressly for the in vivo measurement of radioactive material in Hanford workers. Most routine in vivo measurements are performed annually and special measurements are performed as needed. The primary source terms at the Hanford Site include fission and activation products (primarily 137Cs and 90Sr), uranium, uranium progeny, and transuranic radionuclides. The facility currently houses five shielded counting systems, men's and women's change rooms and an instrument maintenance and repair shop. Four systems include high purity germanium detectors and one system utilizes large sodium iodide detectors. These systems are used to perform an average of 7,000 measurements annually. This includes approximately 5000 whole body measurements analyzed for fission and activation products and 2000 lung measurements analyzed for americium, uranium, and plutonium. Various other types of measurements are performed periodically to estimate activity in wounds, the thyroid, the liver, and the skeleton. The staff maintains the capability to detect and quantify activity in essentially any tissue or organ. The in vivo monitoring program that utilizes the facility is accredited by the Department of Energy Laboratory Accreditation Program for direct radiobioassay.

  6. A Framework for Managing Core Facilities within the Research Enterprise

    OpenAIRE

    Haley, Rand

    2009-01-01

    Core facilities represent increasingly important operational and strategic components of institutions' research enterprises, especially in biomolecular science and engineering disciplines. With this realization, many research institutions are placing more attention on effectively managing core facilities within the research enterprise. A framework is presented for organizing the questions, challenges, and opportunities facing core facilities and the academic units and institutions in which th...

  7. Large power supply facilities for fusion research

    International Nuclear Information System (INIS)

    Miyahara, Akira; Yamamoto, Mitsuyoshi.

    1976-01-01

    The authors had opportunities to manufacture and to operate two power supply facilities, that is, 125MVA computer controlled AC generator with a fly wheel for JIPP-T-2 stellerator in Institute of Plasma Physics, Nagoya University and 3MW trial superconductive homopolar DC generator to the Japan Society for Promotion of Machine Industry. The 125MVA fly-wheel generator can feed both 60MW (6kV x 10kA) DC power for toroidal coils and 20MW (0.5kV x 40kA) DC power for helical coils. The characteristic features are possibility of Bung-Bung control based on Pontrjagin's maximum principle, constant current control or constant voltage control for load coils, and cpu control for routine operation. The 3MW (150V-20000A) homopolar generator is the largest in the world as superconductive one, however, this capacity is not enough for nuclear fusion research. The problems of power supply facilities for large Tokamak devices are discussed

  8. MYRRHA. An innovative and unique research facility

    Energy Technology Data Exchange (ETDEWEB)

    Fernandez, Rafaeol; Neerdael, Bernard; Schyns, Marc; Dyck, Steven Van; Michiels, Sidney; Ait Abderrahim, Hamid, E-mail: myrrha@sckcen.be [Belgian Nuclear Research Centre (SCK-CEN), Mol (Belgium)

    2012-03-15

    The MYRRHA project started in 1998 by SCK{center_dot}CEN in collaboration with Ion Beam Applications (IBA, Louvain-la-Neuve), as an upgrade of the ADONIS project. MYRRHA is designed as a multi-purpose irradiation facility in order to support research programmes on fission and fusion reactor structural materials and nuclear fuel development. Applications of these are found in Accelerator Driven Systems (ADS) systems and in present generation as well as in next generation critical reactors. The first objective of MYRRHA however, will be to demonstrate on one hand the ADS concept at a reasonable power level and on the other hand the technological feasibility of transmutation of Minor Actinides (MA) and Long-Lived Fission Products (LLFP) arising from the reprocessing of radioactive waste. MYRRHA will also help the development of the Pb-alloys technology needed for the LFR (Lead Fast Reactor) Gen.IV concept. Transmutation of MA can be completed in an efficient way in fast neutron spectrum facilities. Both critical reactors and sub-critical ADS are potential candidates as dedicated transmutation systems. However, critical reactors, heavily loaded with fuel containing large amounts of MA, pose safety problems caused by unfavourable reactivity coefficients due to the little delayed neutron fraction. A sub-critical ADS operates in a flexible and safe manner even with a core loading containing a high amount of MA leading to achieve a high efficient transmutation. Thus, the sub-criticality is not a virtue but rather a necessity for an efficient and economical burning of the MA. Besides the reduction of the HLW burden, the MYRRHA project will serve the purpose of developing the lead alloys technology as a reactor coolant that can be used in one of the Generation IV reactor concepts namely the Lead Fast Reactor (LFR). Although carrying out the MYRRHA project will lead to the demonstration of the efficient and safe transmutation of MA in ADS systems as the ultimate goal the

  9. Vehicle Thermal Management Facilities | Transportation Research | NREL

    Science.gov (United States)

    Integration Facility The Vehicle Testing and Integration Facility features a pad to conduct vehicle thermal station next to the pad provides a continuous data stream on temperature, humidity, wind speed, and solar

  10. Facilities available for actinide research in Prague

    International Nuclear Information System (INIS)

    Sechovský, V.

    2014-01-01

    Since June 2012 the Prague group at the Charles University operates a Czech research infrastructure Magnetism and Low Temperature Laboratories (MLTL - http://mltl.eu orhttp://lmnt.cz)which is financially supported by the Government of Czech Republic. The main mission of MLTL is to provide broad scientific community unique possibilities for comprehensive experimental studies of physical phenomena and properties of materials in multiextreme conditions.MLTL offer open access to a wide range of experimental facilities for sample preparation (SSE refinement of staring metals, synthesis of bulk polycrystals, growth of single crystals), characterization (XRD, SEM + EDX) and measurements of various physical properties in high magnetic fields up to 20 T, temperatures from 30 mK to 1000Kand external pressures up to 25 GPa). Anybody can apply for experimental time with his proposal on the user portal of http://mltl.eu. The main strategic objective is the excellence of the infrastructure on the international scale. Therefore the MLTL Panel evaluation the proposals and allocation of experimental time is based primarily on the quality of intended research. The proposals of students for experiments needed for their theses are promoted within the evaluation process. The research opportunities offered by MLTL will be demonstrated during the lecture with emphasis on methodology

  11. Creation of a new-generation research nuclear facility

    International Nuclear Information System (INIS)

    Girchenko, A.A.; Matyushin, A.P.; Kudryavtsev, E.M.; Skopin, V.P.; Shchepelev, R.M.

    2013-01-01

    The SO-2M research nuclear facility operated on the industrial area of the institute. The facility is now removed from service. In view of this circumstance, it is proposed to restore the facility at the new qualitative level, i.e., to create a new-generation research nuclear facility with a very high safety level consisting of a subcritical bench and a proton accelerator (electronuclear facility). Competitive advantages and design features have been discussed and the productive capacity of the research nuclear facility under development has been evaluated [ru

  12. The research progress of genomic selection in livestock.

    Science.gov (United States)

    Li, Hong-wei; Wang, Rui-jun; Wang, Zhi-ying; Li, Xue-wu; Wang, Zhen-yu; Yanjun, Zhang; Rui, Su; Zhihong, Liu; Jinquan, Li

    2017-05-20

    With the development of gene chip and breeding technology, genomic selection in plants and animals has become research hotspots in recent years. Genomic selection has been extensively applied to all kinds of economic livestock, due to its high accuracy, short generation intervals and low breeding costs. In this review, we summarize genotyping technology and the methods for genomic breeding value estimation, the latter including the least square method, RR-BLUP, GBLUP, ssGBLUP, BayesA and BayesB. We also cover basic principles of genomic selection and compare their genetic marker ranges, genomic selection accuracy and operational speed. In addition, we list common indicators, methods and influencing factors that are related to genomic selection accuracy. Lastly, we discuss latest applications and the current problems of genomic selection at home and abroad. Importantly, we envision future status of genomic selection research, including multi-trait and multi-population genomic selection, as well as impact of whole genome sequencing and dominant effects on genomic selection. This review will provide some venues for other breeders to further understand genome selection.

  13. Europlanet Research Infrastructure: Planetary Simulation Facilities

    Science.gov (United States)

    Davies, G. R.; Mason, N. J.; Green, S.; Gómez, F.; Prieto, O.; Helbert, J.; Colangeli, L.; Srama, R.; Grande, M.; Merrison, J.

    2008-09-01

    EuroPlanet The Europlanet Research Infrastructure consortium funded under FP7 aims to provide the EU Planetary Science community greater access for to research infrastructure. A series of networking and outreach initiatives will be complimented by joint research activities and the formation of three Trans National Access distributed service laboratories (TNA's) to provide a unique and comprehensive set of analogue field sites, laboratory simulation facilities, and extraterrestrial sample analysis tools. Here we report on the infrastructure that comprises the second TNA; Planetary Simulation Facilities. 11 laboratory based facilities are able to recreate the conditions found in the atmospheres and on the surfaces of planetary systems with specific emphasis on Martian, Titan and Europa analogues. The strategy has been to offer some overlap in capabilities to ensure access to the highest number of users and to allow for progressive and efficient development strategies. For example initial testing of mobility capability prior to the step wise development within planetary atmospheres that can be made progressively more hostile through the introduction of extreme temperatures, radiation, wind and dust. Europlanet Research Infrastructure Facilties: Mars atmosphere simulation chambers at VUA and OU These relatively large chambers (up to 1 x 0.5 x 0.5 m) simulate Martian atmospheric conditions and the dual cooling options at VUA allows stabilised instrument temperatures while the remainder of the sample chamber can be varied between 220K and 350K. Researchers can therefore assess analytical protocols for instruments operating on Mars; e.g. effect of pCO2, temperature and material (e.g., ± ice) on spectroscopic and laser ablation techniques while monitoring the performance of detection technologies such as CCD at low T & variable p H2O & pCO2. Titan atmosphere and surface simulation chamber at OU The chamber simulates Titan's atmospheric composition under a range of

  14. Lewis Research Center space station electric power system test facilities

    Science.gov (United States)

    Birchenough, Arthur G.; Martin, Donald F.

    1988-01-01

    NASA Lewis Research Center facilities were developed to support testing of the Space Station Electric Power System. The capabilities and plans for these facilities are described. The three facilities which are required in the Phase C/D testing, the Power Systems Facility, the Space Power Facility, and the EPS Simulation Lab, are described in detail. The responsibilities of NASA Lewis and outside groups in conducting tests are also discussed.

  15. High Energy Solid State Laser Research Facility

    Data.gov (United States)

    Federal Laboratory Consortium — A suite of laboratories with advanced spectroscopic and laser equipment, this facility develops materials and techniques for advanced solid state high energy lasers....

  16. [Genomic research of traditional Chinese medicines in vivo metabolism].

    Science.gov (United States)

    Xiao, Shui-Ming; Bai, Rui; Zhang, Xiao-Yan

    2016-11-01

    Gene is the base of in vivo metabolism and effectiveness for traditional Chinese medicines (TCM), and the gene expression, regulation and modification are used as the research directions to perform the TCM multi-component, multi-link and multi-target in vivo metabolism studies, which will improve the research on TCM metabolic proecess, effect target and molecular mechanism. Humans are superorganisms with 1% genes inherited from parents and 99% genes from various parts of the human body, mainly coming from the microorganisms in intestinal flora. These indicate that genetically inherited human genome and "second genome" could affect the TCM in vivo metabolism from inheritance and "environmental" aspects respectively. In the present paper, typical case study was used to discuss related TCM in vivo metabolic genomics research, mainly including TCM genomics research and gut metagenomics research, as well as the personalized medicine evoked from the individual difference of above genomics (metagenomics). Copyright© by the Chinese Pharmaceutical Association.

  17. Research in artificial intelligence for nuclear facilities

    International Nuclear Information System (INIS)

    Uhrig, R.E.

    1990-01-01

    The application of artificial intelligence, in the form of expert systems and neural networks, to the control room activities in a nuclear power plant has the potential to reduce operator error and increase plant safety, reliability, and efficiency. Furthermore, artificial intelligence can increase efficiency and effectiveness in a large number of nonoperating activities (testing, routine maintenance, outage planning, equipment diagnostics, and fuel management) and in research facility experiments. Recent work at the University of Tennessee has demonstrated the feasibility of using neural networks to identify six different transients introduced into the simulation of a steam generator of a nuclear power plant. This work is now being extended to utilize data from a nuclear power plant training simulator. In one configuration, the inputs to the neural network are a subset of the quantities that are typical of those available from the safety parameter display system. The outputs of the network represent the various states of the plant (e.g., normal operation, coolant leakage, inadequate core flow, excessive peak fuel temperature, etc.). Training of the neural network is performed by introducing various faults or conditions to be diagnosed into the simulator. The goal of this work is to demonstrate a neural network diagnostic system that could provide advice to the operators in accordance with the emergency operating procedures

  18. Sanford Underground Research Facility - The United State's Deep Underground Research Facility

    Science.gov (United States)

    Vardiman, D.

    2012-12-01

    The 2.5 km deep Sanford Underground Research Facility (SURF) is managed by the South Dakota Science and Technology Authority (SDSTA) at the former Homestake Mine site in Lead, South Dakota. The US Department of Energy currently supports the development of the facility using a phased approach for underground deployment of experiments as they obtain an advanced design stage. The geology of the Sanford Laboratory site has been studied during the 125 years of operations at the Homestake Mine and more recently as part of the preliminary geotechnical site investigations for the NSF's Deep Underground Science and Engineering Laboratory project. The overall geology at DUSEL is a well-defined stratigraphic sequence of schist and phyllites. The three major Proterozoic units encountered in the underground consist of interbedded schist, metasediments, and amphibolite schist which are crosscut by Tertiary rhyolite dikes. Preliminary geotechnical site investigations included drift mapping, borehole drilling, borehole televiewing, in-situ stress analysis, laboratory analysis of core, mapping and laser scanning of new excavations, modeling and analysis of all geotechnical information. The investigation was focused upon the determination if the proposed site rock mass could support the world's largest (66 meter diameter) deep underground excavation. While the DUSEL project has subsequently been significantly modified, these data are still available to provide a baseline of the ground conditions which may be judiciously extrapolated throughout the entire Proterozoic rock assemblage for future excavations. Recommendations for facility instrumentation and monitoring were included in the preliminary design of the DUSEL project design and include; single and multiple point extensometers, tape extensometers and convergence measurements (pins), load cells and pressure cells, smart cables, inclinometers/Tiltmeters, Piezometers, thermistors, seismographs and accelerometers, scanners (laser

  19. A comprehensive crop genome research project: the Superhybrid Rice Genome Project in China.

    Science.gov (United States)

    Yu, Jun; Wong, Gane Ka-Shu; Liu, Siqi; Wang, Jian; Yang, Huanming

    2007-06-29

    In May 2000, the Beijing Institute of Genomics formally announced the launch of a comprehensive crop genome research project on rice genomics, the Chinese Superhybrid Rice Genome Project. SRGP is not simply a sequencing project targeted to a single rice (Oryza sativa L.) genome, but a full-swing research effort with an ultimate goal of providing inclusive basic genomic information and molecular tools not only to understand biology of the rice, both as an important crop species and a model organism of cereals, but also to focus on a popular superhybrid rice landrace, LYP9. We have completed the first phase of SRGP and provide the rice research community with a finished genome sequence of an indica variety, 93-11 (the paternal cultivar of LYP9), together with ample data on subspecific (between subspecies) polymorphisms, transcriptomes and proteomes, useful for within-species comparative studies. In the second phase, we have acquired the genome sequence of the maternal cultivar, PA64S, together with the detailed catalogues of genes uniquely expressed in the parental cultivars and the hybrid as well as allele-specific markers that distinguish parental alleles. Although SRGP in China is not an open-ended research programme, it has been designed to pave a way for future plant genomics research and application, such as to interrogate fundamentals of plant biology, including genome duplication, polyploidy and hybrid vigour, as well as to provide genetic tools for crop breeding and to carry along a social burden-leading a fight against the world's hunger. It began with genomics, the newly developed and industry-scale research field, and from the world's most populous country. In this review, we summarize our scientific goals and noteworthy discoveries that exploit new territories of systematic investigations on basic and applied biology of rice and other major cereal crops.

  20. Combustion Research Facility | A Department of Energy Office of Science

    Science.gov (United States)

    Collaborative Research Facility Back to Sandia National Laboratory Homepage Combustion Research Search the CRF Combustion Chemistry Flame Chemistry Research.Combustion_Chemistry.Flame_Chemistry Theory and Modeling Theory and Modeling Combustion Kinetics High Pressure Chemistry Chemistry of Autoignition

  1. Research Facilities for the Future of Nuclear Energy

    International Nuclear Information System (INIS)

    Ait Abderrahim, H.

    1996-01-01

    The proceedings of the ENS Class 1 Topical Meeting on Research facilities for the Future of Nuclear Energy include contributions on large research facilities, designed for tests in the field of nuclear energy production. In particular, issues related to facilities supporting research and development programmes in connection to the operation of nuclear power plants as well as the development of new concepts in material testing, nuclear data measurement, code validation, fuel cycle, reprocessing, and waste disposal are discussed. The proceedings contain 63 papers

  2. 50 Years of the Radiological Research Accelerator Facility (RARAF)

    OpenAIRE

    Marino, Stephen A.

    2017-01-01

    The Radiological Research Accelerator Facility (RARAF) is in its 50th year of operation. It was commissioned on April 1, 1967 as a collaboration between the Radiological Research Laboratory (RRL) of Columbia University, and members of the Medical Research Center of Brookhaven National Laboratory (BNL). It was initially funded as a user facility for radiobiology and radiological physics, concentrating on monoenergetic neutrons. Facilities for irradiation with MeV light charged particles were d...

  3. Shock Thermodynamic Applied Research Facility (STAR)

    Data.gov (United States)

    Federal Laboratory Consortium — The STAR facility, within Sandia's Solid Dynamic Physics Department, is one of a few institutions in the world with a major shock-physics program. This is the only...

  4. Space Station life science research facility - The vivarium/laboratory

    Science.gov (United States)

    Hilchey, J. D.; Arno, R. D.

    1985-01-01

    Research opportunities possible with the Space Station are discussed. The objective of the research program will be study gravity relationships for animal and plant species. The equipment necessary for space experiments including vivarium facilities are described. The cost of the development of research facilities such as the vivarium/laboratory and a bioresearch centrifuge is examined.

  5. Research highlights from the Holifield Heavy Ion Research Facility

    International Nuclear Information System (INIS)

    Plasil, F.

    1982-01-01

    The purpose of this paper is to present the scope of research carried out at the new Holifield Heavy Ion Research Facility (HHIRF) at Oak Ridge. This will be accomplished with reference to several research projects currently underway. The areas of research represented are microscopic and macroscopic aspects of nuclear reactions and nuclear structure. In view of the scope of this conference, emphasis will be placed on nuclear reactions. A brief description of HHIRF is given, together with its current status. Microscopic aspects of reactions between nuclei are discussed with reference to the prospects for the study of giant resonances by means of heavy ions, and to studies of elastic and inelastic scattering of 60 Ni nuclei. Macroscopic aspects of nuclear reactions are illustrated by means of the study of collisions between 58 Ni nuclei at 15.1 MeV/u and by means of Spin Spectrometer (crystal ball) studies of the 19 F + 159 Tb reaction. Results are presented for lifetime measurements of high-spin states in ytterbium nuclei

  6. Trends of researches for fusion engineering research facility (FERF)

    International Nuclear Information System (INIS)

    Ozawa, Yasutomo; Enoto, Takeaki

    1975-01-01

    The role of a fusion neutron radiation test facility in the development of a scientific feasibility experimental reactor or demonstration fusion power reactor plant would be analogous to the role of the materials testing and experimental reactors in the development of fission power reactor. While the material testing fission reactor has been developed after successful operation of fission reactors, in the case of fusion reactor development it is desirable to realize the fusion engineering research facility (FERF) in-phase to the development of SFX and/or demonstration fusion power reactor plants. Here so called FERF in near future is the Controlled Thermonuclear Reactor which provides the high-intensity and high-energy neutron and plasma source whether the net power output is produced or not. From the point of direct attainment to SFX, we would like to emphasize that FEFE is the royal road leading to the goal of successful achievement of CTR program and could be useful for the experiment on impurity effects caused by neutron and plasma irradiations onto the wall material for SFX. Further, we rather suppose that hybrid FERF-fission assembly could be fairly and easily realizable in near future. (auth.)

  7. Hydrogen Infrastructure Testing and Research Facility Video (Text Version)

    Science.gov (United States)

    grid integration, continuous code improvement, fuel cell vehicle operation, and renewable hydrogen Systems Integration Facility or ESIF. Research projects including H2FIRST, component testing, hydrogen

  8. An outline of research facilities of high intensity proton accelerator

    International Nuclear Information System (INIS)

    Tanaka, Shun-ichi

    1995-01-01

    A plan called PROTON ENGINEERING CENTER has been proposed in JAERI. The center is a complex composed of research facilities and a beam shape and storage ring based on a proton linac with an energy of 1.5 GeV and an average current of 10 mA. The research facilities planned are OMEGA·Nuclear Energy Development Facility, Neutron Facility for Material Irradiation, Nuclear Data Experiment Facility, Neutron Factory, Meson Factory, spallation Radioisotope Beam Facility, and Medium Energy Experiment Facility, where high intensity proton beam and secondary particle beams such as neutrons, π-mesons, muons, and unstable isotopes originated from the protons are available for promoting the innovative research of nuclear energy and basic science and technology. (author)

  9. Partnering for functional genomics research conference: Abstracts of poster presentations

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-06-01

    This reports contains abstracts of poster presentations presented at the Functional Genomics Research Conference held April 16--17, 1998 in Oak Ridge, Tennessee. Attention is focused on the following areas: mouse mutagenesis and genomics; phenotype screening; gene expression analysis; DNA analysis technology development; bioinformatics; comparative analyses of mouse, human, and yeast sequences; and pilot projects to evaluate methodologies.

  10. Corium melt researches at VESTA test facility

    Directory of Open Access Journals (Sweden)

    Hwan Yeol Kim

    2017-10-01

    Full Text Available VESTA (Verification of Ex-vessel corium STAbilization and VESTA-S (-small test facilities were constructed at the Korea Atomic Energy Research Institute in 2010 to perform various corium melt experiments. Since then, several tests have been performed for the verification of an ex-vessel core catcher design for the EU-APR1400. Ablation tests of an impinging ZrO2 melt jet on a sacrificial material were performed to investigate the ablation characteristics. ZrO2 melt in an amount of 65–70 kg was discharged onto a sacrificial material through a well-designed nozzle, after which the ablation depths were measured. Interaction tests between the metallic melt and sacrificial material were performed to investigate the interaction kinetics of the sacrificial material. Two types of melt were used: one is a metallic corium melt with Fe 46%, U 31%, Zr 16%, and Cr 7% (maximum possible content of U and Zr for C-40, and the other is a stainless steel (SUS304 melt. Metallic melt in an amount of 1.5–2.0 kg was delivered onto the sacrificial material, and the ablation depths were measured. Penetration tube failure tests were performed for an APR1400 equipped with 61 in-core instrumentation penetration nozzles and extended tubes at the reactor lower vessel. ZrO2 melt was generated in a melting crucible and delivered down into an interaction crucible where the test specimen is installed. To evaluate the tube ejection mechanism, temperature distributions of the reactor bottom head and in-core instrumentation penetration were measured by a series of thermocouples embedded along the specimen. In addition, lower vessel failure tests for the Fukushima Daiichi nuclear power plant are being performed. As a first step, the configuration of the molten core in the plant was investigated by a melting and solidification experiment. Approximately 5 kg of a mixture, whose composition in terms of weight is UO2 60%, Zr 10%, ZrO2 15%, SUS304 14%, and B4C 1%, was melted in a

  11. Metering management at the plutonium research and development facilities

    International Nuclear Information System (INIS)

    Hirata, Masaru; Miyamoto, Fujio; Kurosawa, Makoto; Abe, Jiro; Sakai, Haruyuki; Suzuki, Tsuneo.

    1996-01-01

    Nuclear fuel research laboratory of the Oarai Research Laboratory of the Japan Atomic Energy Research Institute is an R and D facility to treat with plutonium and processes various and versatile type samples in chemical and physical form for use of various experimental researches even though on much small amount. Furthermore, wasted and plutonium samples are often transported to other KMP and MBA such as radioactive waste management facility, nuclear reactor facility and so forth. As this facility is a place to treat plutonium important on the safeguards, it is a facility necessary for detection and allowance actions and for detail managements on the metering management data to report to government and IAEA in each small amount sample and different configuration. In this paper, metering management of internationally regulated matters and metering management system using a work station newly produced in such small scale facility were introduced. (G.K.)

  12. Human genome and genetic sequencing research and informed consent

    International Nuclear Information System (INIS)

    Iwakawa, Mayumi

    2003-01-01

    On March 29, 2001, the Ethical Guidelines for Human Genome and Genetic Sequencing Research were established. They have intended to serve as ethical guidelines for all human genome and genetic sequencing research practice, for the purpose of upholding respect for human dignity and rights and enforcing use of proper methods in the pursuit of human genome and genetic sequencing research, with the understanding and cooperation of the public. The RadGenomics Project has prepared a research protocol and informed consent document that follow these ethical guidelines. We have endeavored to protect the privacy of individual information, and have established a procedure for examination of research practices by an ethics committee. Here we report our procedure in order to offer this concept to the patients. (authors)

  13. DOE research and development and field facilities

    Energy Technology Data Exchange (ETDEWEB)

    1979-06-01

    This report describes the roles of DOE's headquarters, field offices, major multiprogram laboratories, Energy Technology and Mining Operations Centers, and other government-owned, contractor-operated facilities which are located in all regions of the United States. It gives brief descriptions of resources, activities, and capabilities of each field facility (sections III through V). These represent a cumulative capital investment of $12 billion and involve a work force of approximately 12,000 government (field) employees and approximately 100,000 contractor employees.

  14. Research for genetic instability of human genome

    Energy Technology Data Exchange (ETDEWEB)

    Hori, T.; Takahashi, E.; Tsuji, H.; Yamauchi, M. (National Inst. of Radiological Sciences, Chiba (Japan)); Murata, M.

    1992-01-01

    In the present review paper, the potential relevance of chromosomal fragile sites to carcinogenesis and mutagenesis is discussed based on our own and other's studies. Recent evidence indicate that fragile sites may act as predisposition factors involved in chromosomal instability of the human genome and that the sites may be preferential targets for various DNA damaging agents including ionizing radiation. It is also demonstrated that some critical genomic rearrangements at the fragile sites may contribute towards oncogenesis and that individuals carrying heritable form of fragile site may be at the risk. Although clinical significance of autosomal fragile sites has been a matter of discussion, a fragile site of the X chromosome is known to be associated with an X-linked genetic diseases, called fragile X syndrome. Molecular events leading to the fragile X syndrome have recently been elucidated. The fragile X genotype can be characterized by an increased amount of p(CCG)n repeat DNA sequence in the FMR-1 gene and the repeated sequences are shown to be unstable in both meiosis and mitosis. These repeats might exhibit higher mutation rate than is generally seen in the human genome. Further studies on the fragile sites in molecular biology and radiation biology will yield relevant data to the molecular mechanisms of genetic instability of the human genome as well as to better assessment of genetic effect of ionizing radiation. (author).

  15. Research for genetic instability of human genome

    International Nuclear Information System (INIS)

    Hori, T.; Takahashi, E.; Tsuji, H.; Yamauchi, M.; Murata, M.

    1992-01-01

    In the present review paper, the potential relevance of chromosomal fragile sites to carcinogenesis and mutagenesis is discussed based on our own and other's studies. Recent evidence indicate that fragile sites may act as predisposition factors involved in chromosomal instability of the human genome and that the sites may be preferential targets for various DNA damaging agents including ionizing radiation. It is also demonstrated that some critical genomic rearrangements at the fragile sites may contribute towards oncogenesis and that individuals carrying heritable form of fragile site may be at the risk. Although clinical significance of autosomal fragile sites has been a matter of discussion, a fragile site of the X chromosome is known to be associated with an X-linked genetic diseases, called fragile X syndrome. Molecular events leading to the fragile X syndrome have recently been elucidated. The fragile X genotype can be characterized by an increased amount of p(CCG)n repeat DNA sequence in the FMR-1 gene and the repeated sequences are shown to be unstable in both meiosis and mitosis. These repeats might exhibit higher mutation rate than is generally seen in the human genome. Further studies on the fragile sites in molecular biology and radiation biology will yield relevant data to the molecular mechanisms of genetic instability of the human genome as well as to better assessment of genetic effect of ionizing radiation. (author)

  16. Avian Polyomavirus Genome Sequences Recovered from Parrots in Captive Breeding Facilities in Poland.

    Science.gov (United States)

    Dayaram, Anisha; Piasecki, Tomasz; Chrząstek, Klaudia; White, Robyn; Julian, Laurel; van Bysterveldt, Katherine; Varsani, Arvind

    2015-09-24

    Eight genomes of avian polyomaviruses (APVs) were recovered and sequenced from deceased Psittacula eupatria, Psittacula krameri, and Melopsittacus undulatus from various breeding facilities in Poland. Of these APV-positive samples, six had previously tested positive for beak and feather disease virus (BFDV) and/or parrot hepatitis B virus (PHBV). Copyright © 2015 Dayaram et al.

  17. Avian Polyomavirus Genome Sequences Recovered from Parrots in Captive Breeding Facilities in Poland

    OpenAIRE

    Dayaram, Anisha; Piasecki, Tomasz; Chrząstek, Klaudia; White, Robyn; Julian, Laurel; van Bysterveldt, Katherine; Varsani, Arvind

    2015-01-01

    Eight genomes of avian polyomaviruses (APVs) were recovered and sequenced from deceased Psittacula eupatria, Psittacula krameri, and Melopsittacus undulatus from various breeding facilities in Poland. Of these APV-positive samples, six had previously tested positive for beak and feather disease virus (BFDV) and/or parrot hepatitis B virus (PHBV).

  18. Naval Research Laboratory Major Facilities 2008

    Science.gov (United States)

    2008-10-01

    consists of two equipment shelters, a chiller for cooling the transmitter, and a 175 kVA diesel generator for use at remote sites. A 40-ft-long... bioremediation , and biodeterioration. INSTRUMENTATION: • ESEM equipped with an energy-dispersive X-ray detector and an image acquisition and...a 125 kW uninterruptible power system with diesel backup. Magnetic sensitivity testing of precision Precision Clock Evaluation Facility CONTACT

  19. Decontamination Technology Development for Nuclear Research Facilities

    International Nuclear Information System (INIS)

    Oh, Won Zin; Jung, Chong Hun; Choi, Wang Kyu; Won, Hui Jun; Kim, Gye Nam

    2004-02-01

    Technology development of surface decontamination in the uranium conversion facility before decommissioning, technology development of component decontamination in the uranium conversion facility after decommissioning, uranium sludge treatment technology development, radioactive waste soil decontamination technology development at the aim of the temporary storage soil of KAERI, Optimum fixation methodology derivation on the soil and uranium waste, and safety assessment methodology development of self disposal of the soil and uranium waste after decontamination have been performed in this study. The unique decontamination technology applicable to the component of the nuclear facility at room temperature was developed. Low concentration chemical decontamination technology which is very powerful so as to decrease the radioactivity of specimen surface under the self disposal level was developed. The component decontamination technology applicable to the nuclear facility after decommissioning by neutral salt electro-polishing was also developed. The volume of the sludge waste could be decreased over 80% by the sludge waste separation method by water. The electrosorption method on selective removal of U(VI) to 1 ppm of unrestricted release level using the uranium-containing lagoon sludge waste was tested and identified. Soil decontamination process and equipment which can reduce the soil volume over 90% were developed. A pilot size of soil decontamination equipment which will be used to development of real scale soil decontamination equipment was designed, fabricated and demonstrated. Optimized fixation methodology on soil and uranium sludge was derived from tests and evaluation of the results. Safety scenario and safety evaluation model were development on soil and uranium sludge aiming at self disposal after decontamination

  20. Implementation Plans for a Systems Microbiology and Extremophile Research Facility

    Energy Technology Data Exchange (ETDEWEB)

    Wiley, H. S.

    2009-04-20

    solve DOE problems. Recent advances in whole-genome sequencing for a variety of organisms and improvements in high-throughput instrumentation have contributed to a rapid transition of the biological research paradigm towards understanding biology at a systems level. As a result, biology is evolving from a descriptive to a quantitative, ultimately predictive science where the ability to collect and productively use large amounts of biological data is crucial. Understanding how the ensemble of proteins in cells gives rise to biological outcomes is fundamental to systems biology. These advances will require new technologies and approaches to measure and track the temporal and spatial disposition of proteins in cells and how networks of proteins and other regulatory molecules give rise to specific activities. The DOE has a strong interest in promoting the application of systems biology to understanding microbial function and this comprises a major focus of its Genomics:GTL program. A major problem in pursuing what has been termed “systems microbiology” is the lack of the facilities and infrastructure for conducting this new style of research. To solve this problem, the Genomics:GTL program has funded a number of large-scale research centers focused on either mission-oriented outcomes, such as bioenergy, or basic technologies, such as gene sequencing, high-throughput proteomics or the identification of protein complexes. Although these centers generate data that will be useful to the research community, their scientific goals are relatively narrow and are not designed to accommodate the general community need for advanced capabilities for systems microbiology research.

  1. General problems specific to hot nuclear materials research facilities

    International Nuclear Information System (INIS)

    Bart, G.

    1996-01-01

    During the sixties, governments have installed hot nuclear materials research facilities to characterize highly radioactive materials, to describe their in-pile behaviour, to develop and test new reactor core components, and to provide the industry with radioisotopes. Since then, the attitude towards the nuclear option has drastically changed and resources have become very tight. Within the changed political environment, the national research centres have defined new objectives. Given budgetary constraints, nuclear facilities have to co-operate internationally and to look for third party research assignments. The paper discusses the problems and needs within experimental nuclear research facilities as well as industrial requirements. Special emphasis is on cultural topics (definition of the scope of nuclear research facilities, the search for competitive advantages, and operational requirements), social aspects (overageing of personnel, recruitment, and training of new staff), safety related administrative and technical issues, and research needs for expertise and state of the art analytical infrastructure

  2. National facility for neutron beam research

    Indian Academy of Sciences (India)

    In this talk, the growth of neutron beam research (NBR) in India over the past five decades is traced beginning with research at Apsara. A range of problems in condensed matter physics could be studied at CIRUS, followed by sophisticated indegenous instrumentation and research at Dhruva. The talk ends with an overview ...

  3. Human genome program report. Part 2, 1996 research abstracts

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-11-01

    This report contains Part 2 of a two-part report to reflect research and progress in the US Department of Energy Human Genome Program from 1994 through 1996, with specified updates made just before publication. Part 2 consists of 1996 research abstracts. Attention is focused on the following: sequencing; mapping; informatics; ethical, legal, and social issues; infrastructure; and small business innovation research.

  4. A low-temperature research facility for space

    International Nuclear Information System (INIS)

    Donnelly, R.J.

    1991-01-01

    The Jet Propulsion Laboratory is proposing to NASA a new initiative to construct a Low Temperature Research Facility for use in space. The facility is described, together with some details of timing and support. An advisory group has been formed which seeks to advise JPL and NASA of the capabilities required in this facility and to invite investigators to propose experiments which require the combination of low temperature and reduced gravity to be successful. (orig.)

  5. Accelerator based research facility as an inter university centre

    International Nuclear Information System (INIS)

    Mehta, G.K.

    1995-01-01

    15 UD pelletron has been operating as a user facility from July 1991. It is being utilised by a large number of universities and other institutions for research in basic Nuclear Physics, Materials Science, Atomic Physics, Radiobiology and Radiation Chemistry. There is an on-going programme for augmenting the accelerator facilities by injecting Pelletron beams into superconducting linear accelerator modules. Superconducting niobium resonator is being developed in Argonne National Laboratory as a joint collaborative effort. All other things such as cryostats, rf instrumentation, cryogenic distribution system, computer control etc are being done indigenously. Research facilities, augmentation plans and the research being conducted by the universities in various disciplines are described. (author)

  6. Radiation applications research and facilities in AECL Research Company

    International Nuclear Information System (INIS)

    Iverson, S.L.

    1988-01-01

    In the 60's and 70's Atomic Energy of Canada had a very active R and D program to discover and develop applications of ionizing radiation. Widespread interest in the use of radiation for food processing and the possibility of developing reliable and competitive machine sources of radiation hold out the promise of a major increase in industrial use of radiation. In March 1985 a new branch, Radiation Applications Research, began operations with the objective of working closely with industry to develop and assist the introduction of new uses of ionizing radiation. The Branch is equipped with appropriate analytical equipment including HPLC (high performance liquid chromatograph) and GC/MS (gas chromatograph/mass spectrometer) as well as a Gammacell 220 and an I-10/1, one kilowatt 10 MeV electron accelerator. The accelerator is located in a specially designed facility equipped for experimental irradiation of the test quantities of packaged products as well as solids, liquids and gases in various configurations. A conveyor system moves the packaged products from the receiving area, through a maze, past the electron beam at a controlled rate and finally to the shipping area. Other necessary capabilities, such as gamma and electron dosimetry and a microbiology laboratory, have also been developed. Initial projects in areas ranging from food through environmental and industrial applications have been assessed and the most promising have been selected for further work. As an example, the use of charcoal absorbent beds to concentrate the components of gas or liquid waste streams requiring treatment is showing promise as a method of significantly reducing the cost of radiation treatment for some effluents. A number of other projects are described. (author)

  7. Profiles of facilities used for HTR research and testing

    International Nuclear Information System (INIS)

    1980-05-01

    This report contains a current description of facilities supporting HTR research and development submitted by countries participating in the IWGFR. It has the purpose of providing an overview of the facilities available for use and of the types of experiments that can be conducted therein

  8. 75 FR 8374 - National Human Genome Research Institute; Notice of Closed Meeting

    Science.gov (United States)

    2010-02-24

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Human Genome... unwarranted invasion of personal privacy. Name of Committee: National Human Genome Research Institute Special... Officer, Scientific Review Branch, National Human Genome Research Institute, National Institutes of Health...

  9. 77 FR 5035 - National Human Genome Research Institute; Notice of Closed Meetings

    Science.gov (United States)

    2012-02-01

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Human Genome... clearly unwarranted invasion of personal privacy. Name of Committee: National Human Genome Research... Officer, Scientific Review Branch, National Human Genome Research Institute, National Institutes of Health...

  10. 78 FR 64222 - National Human Genome Research Institute; Notice of Closed Meetings

    Science.gov (United States)

    2013-10-28

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Human Genome... clearly unwarranted invasion of personal privacy. Name of Committee: National Human Genome Research... Review, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, 301...

  11. 77 FR 20646 - National Human Genome Research Institute; Notice of Closed Meetings

    Science.gov (United States)

    2012-04-05

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Human Genome... clearly unwarranted invasion of personal privacy. Name of Committee: National Human Genome Research.... Agenda: To review and evaluate grant applications. Place: National Human Genome Research Institute, 5635...

  12. 77 FR 58402 - National Human Genome Research Institute; Notice of Closed Meetings

    Science.gov (United States)

    2012-09-20

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Human Genome... clearly unwarranted invasion of personal privacy. Name of Committee: National Human Genome Research...: To review and evaluate grant applications. Place: National Human Genome Research Institute, 5635...

  13. 78 FR 55752 - National Human Genome Research Institute; Notice of Closed Meetings

    Science.gov (United States)

    2013-09-11

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Human Genome... clearly unwarranted invasion of personal privacy. Name of Committee: National Human Genome Research.... Pozzatti, Ph.D., Scientific Review Officer, Scientific Review Branch, National Human Genome Research...

  14. 78 FR 56905 - National Human Genome Research Institute; Notice of Closed Meeting

    Science.gov (United States)

    2013-09-16

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Human Genome... clearly unwarranted invasion of personal privacy. Name of Committee: National Human Genome Research....m. Agenda: To review and evaluate grant applications. Place: National Human Genome Research...

  15. 76 FR 28056 - National Human Genome Research Institute; Notice of Closed Meeting

    Science.gov (United States)

    2011-05-13

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Human Genome... Counselors, National Human Genome Research Institute. The meeting will be closed to the public as indicated... National Human Genome Research Institute, including consideration of personnel qualifications and...

  16. 76 FR 17930 - National Human Genome Research Institute; Notice of Closed Meeting

    Science.gov (United States)

    2011-03-31

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Human Genome... unwarranted invasion of personal privacy. Name of Committee: National Human Genome Research Institute Special... Review Officer, Scientific Review Branch, National Human Genome Research Institute, 5635 Fishers Lane...

  17. 77 FR 59933 - National Human Genome Research Institute; Notice of Closed Meetings

    Science.gov (United States)

    2012-10-01

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Human Genome... clearly unwarranted invasion of personal privacy. Name of Committee: National Human Genome Research....D., Scientific Review Officer, Scientific Review Branch, National Human Genome Research Institute...

  18. 78 FR 107 - National Human Genome Research Institute; Notice of Closed Meeting

    Science.gov (United States)

    2013-01-02

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Human Genome... evaluate grant applications. Place: National Human Genome Research Institute, 3rd Floor Conference Room....D., Scientific Review Officer, Scientific Review Branch, National Human Genome Research Institute...

  19. 76 FR 58023 - National Human Genome Research Institute; Notice of Closed Meeting

    Science.gov (United States)

    2011-09-19

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Human Genome... unwarranted invasion of personal privacy. Name of Committee: National Human Genome Research Institute Initial..., Scientific Review Officer, Office of Scientific Review, National Human Genome Research Institute, National...

  20. 77 FR 28888 - National Human Genome Research Institute Notice of Closed Meeting

    Science.gov (United States)

    2012-05-16

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Human Genome... unwarranted invasion of personal privacy. Name of Committee: National Human Genome Research Institute Initial...: To review and evaluate grant applications. Place: National Human Genome Research Institute, 3635...

  1. 78 FR 70063 - National Human Genome Research Institute; Notice of Closed Meeting

    Science.gov (United States)

    2013-11-22

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Human Genome... Counselors, National Human Genome Research Institute. The meeting will be closed to the public as indicated... NATIONAL HUMAN GENOME RESEARCH INSTITUTE, including consideration of personnel qualifications and...

  2. 78 FR 9707 - National Human Genome Research Institute; Notice of Closed Meetings

    Science.gov (United States)

    2013-02-11

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Human Genome... clearly unwarranted invasion of personal privacy. Name of Committee: National Human Genome Research... Officer, Scientific Review Branch, National Human Genome Research Institute, 5635 Fishers Lane, Suite 4076...

  3. 77 FR 71604 - National Human Genome Research Institute; Notice of Closed Meeting

    Science.gov (United States)

    2012-12-03

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Human Genome... unwarranted invasion of personal privacy. Name of Committee: National Human Genome Research Institute Special..., Scientific Review Branch, National Human Genome Research Institute, National Institutes of Health, 5635...

  4. 76 FR 5390 - National Human Genome Research Institute; Notice of Closed Meeting

    Science.gov (United States)

    2011-01-31

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Human Genome... unwarranted invasion of personal privacy. Place: National Human Genome Research Institute Special Emphasis... Officer, Scientific Review Branch, National Human Genome Research Institute, 5635 Fishers Lane, Suite 4076...

  5. 75 FR 13558 - National Human Genome Research Institute; Notice of Closed Meeting

    Science.gov (United States)

    2010-03-22

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Human Genome... Counselors, National Human Genome Research Institute. The meeting will be closed to the public as indicated... National Human Genome Research Institute, including consideration of personnel qualifications and...

  6. 76 FR 29772 - National Human Genome Research Institute; Notice of Closed Meetings

    Science.gov (United States)

    2011-05-23

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Human Genome... clearly unwarranted invasion of personal privacy. Name of Committee: National Human Genome Research... of Scientific Review, National Human Genome Research Institute, National Institutes of Health...

  7. Radiation applications research and facilities in AECL research company

    Science.gov (United States)

    Iverson, S. L.

    In the 60's and 70's Atomic Energy of Canada had a very active R&D program to discover and develop applications of ionizing radiation. Out of this grew the technology underlying the company's current product line of industrial irradiators. With the commercial success of that product line the company turned its R&D attention to other activities. Presently, widespread interest in the use of radiation for food processing and the possibility of developing reliable and competitive machine sources of radiation hold out the promise of a major increase in industrial use of radiation. While many of the applications being considered are straightforward applications of existing knowledge, others depend on more subtle effects including combined effects of two or more agents. Further research is required in these areas. In March 1985 a new branch, Radiation Applications Research, began operations with the objective of working closely with industry to develop and assist the introduction of new uses of ionizing radiation. The Branch is equipped with appropriate analytical equipment including HPLC (high performance liquid chromatograph) and GC/MS (gas chromatograph/mass spectrometer) as well as a Gammacell 220 and an I-10/1, one kilowatt 10 MeV electron accelerator. The accelerator is located in a specially designed facility equipped for experimental irradiation of test quantities of packaged products as well as solids, liquids and gases in various configurations. A conveyor system moves the packaged products from the receiving area, through a maze, past the electron beam at a controlled rate and finally to the shipping area. Other necessary capabilities, such as gamma and electron dosimetry and a microbiology laboratory, have also been developed. Initial projects in areas ranging from food through environmental and industrial applications have been assessed and the most promising have been selected for further work. As an example, the use of charcoal adsorbent beds to concentrate

  8. About the Epidemiology and Genomics Research Program

    Science.gov (United States)

    Epidemiology is the scientific study of the causes and distribution of disease in populations. NCI-funded epidemiology research is conducted through research at institutions in the United States and internationally.

  9. Introduction of neutron research facilities in Indonesia Nuclear Agency

    International Nuclear Information System (INIS)

    Nishida, Masayuki; Muslih, M. Refai; Minakawa, Nobuaki

    2004-01-01

    In this report, some facilities for neutron diffraction installed in Indonesia nuclear Agency (BATAN) are introduced. Rough sketch of BATAN, and facility arrangement in the reactor hall and the guide hall are schematically shown. The four facilities (powder diffractometer, four-circle goniometer, three-axis goniometer and neutron radiography system) are installed in the reactor hall and the three (small angle neutron scattering (SANS), high resolution SANS and high resolution powder diffractometer) in the guide hall. Neutron wavelengths determined from four hk1 planes of standard Si powder by the BATAN's neutron diffraction facility are compared with those measured by the similar facility in Japan Atomic Energy Research Institute (JAERI). The neutron diffraction profile of W-fiber reinforced Cu composite is measured by the BATAN's facility. The experimental results show the strong 110 preferred orientation to the fiber direction. (author)

  10. Environment for Auditory Research Facility (EAR)

    Data.gov (United States)

    Federal Laboratory Consortium — EAR is an auditory perception and communication research center enabling state-of-the-art simulation of various indoor and outdoor acoustic environments. The heart...

  11. Small Multi-Purpose Research Facility (SMiRF)

    Data.gov (United States)

    Federal Laboratory Consortium — The Small Multi-Purpose Research Facility (SMiRF) evaluates the performance of the thermal protection systems required to provide long-term storage (up to 10 years)...

  12. Direct Connect Supersonic Combustion Facility (Research Cell 22)

    Data.gov (United States)

    Federal Laboratory Consortium — Description: RC22 is a continuous-flow, direct-connect supersonic-combustion research facility that is capable of simulating flight conditions from Mach 3.0 to Mach...

  13. Harvard Personal Genome Project: lessons from participatory public research

    Science.gov (United States)

    2014-01-01

    Background Since its initiation in 2005, the Harvard Personal Genome Project has enrolled thousands of volunteers interested in publicly sharing their genome, health and trait data. Because these data are highly identifiable, we use an ‘open consent’ framework that purposefully excludes promises about privacy and requires participants to demonstrate comprehension prior to enrollment. Discussion Our model of non-anonymous, public genomes has led us to a highly participatory model of researcher-participant communication and interaction. The participants, who are highly committed volunteers, self-pursue and donate research-relevant datasets, and are actively engaged in conversations with both our staff and other Personal Genome Project participants. We have quantitatively assessed these communications and donations, and report our experiences with returning research-grade whole genome data to participants. We also observe some of the community growth and discussion that has occurred related to our project. Summary We find that public non-anonymous data is valuable and leads to a participatory research model, which we encourage others to consider. The implementation of this model is greatly facilitated by web-based tools and methods and participant education. Project results are long-term proactive participant involvement and the growth of a community that benefits both researchers and participants. PMID:24713084

  14. Harvard Personal Genome Project: lessons from participatory public research.

    Science.gov (United States)

    Ball, Madeleine P; Bobe, Jason R; Chou, Michael F; Clegg, Tom; Estep, Preston W; Lunshof, Jeantine E; Vandewege, Ward; Zaranek, Alexander; Church, George M

    2014-02-28

    Since its initiation in 2005, the Harvard Personal Genome Project has enrolled thousands of volunteers interested in publicly sharing their genome, health and trait data. Because these data are highly identifiable, we use an 'open consent' framework that purposefully excludes promises about privacy and requires participants to demonstrate comprehension prior to enrollment. Our model of non-anonymous, public genomes has led us to a highly participatory model of researcher-participant communication and interaction. The participants, who are highly committed volunteers, self-pursue and donate research-relevant datasets, and are actively engaged in conversations with both our staff and other Personal Genome Project participants. We have quantitatively assessed these communications and donations, and report our experiences with returning research-grade whole genome data to participants. We also observe some of the community growth and discussion that has occurred related to our project. We find that public non-anonymous data is valuable and leads to a participatory research model, which we encourage others to consider. The implementation of this model is greatly facilitated by web-based tools and methods and participant education. Project results are long-term proactive participant involvement and the growth of a community that benefits both researchers and participants.

  15. A facility for using cluster research to study environmental problems

    Energy Technology Data Exchange (ETDEWEB)

    1991-11-01

    This report begins by describing the general application of cluster based research to environmental chemistry and the development of a Cluster Structure and Dynamics Research Facility (CSDRF). Next, four important areas of cluster research are described in more detail, including how they can impact environmental problems. These are: surface-supported clusters, water and contaminant interactions, time-resolved dynamic studies in clusters, and cluster structures and reactions. These facilities and equipment required for each area of research are then presented. The appendices contain workshop agenda and a listing of the researchers who participated in the workshop discussions that led to this report.

  16. A facility for using cluster research to study environmental problems

    International Nuclear Information System (INIS)

    1991-11-01

    This report begins by describing the general application of cluster based research to environmental chemistry and the development of a Cluster Structure and Dynamics Research Facility (CSDRF). Next, four important areas of cluster research are described in more detail, including how they can impact environmental problems. These are: surface-supported clusters, water and contaminant interactions, time-resolved dynamic studies in clusters, and cluster structures and reactions. These facilities and equipment required for each area of research are then presented. The appendices contain workshop agenda and a listing of the researchers who participated in the workshop discussions that led to this report

  17. Confinement Physics Research Facility/ZTH: A progress report

    International Nuclear Information System (INIS)

    Hammer, C.F.; Thullen, P.

    1989-01-01

    In October 1985 the Los Alamos National Laboratory's Controlled Thermonuclear Research (CTR) Division began the design and construction of the Confinement Physics Research Facility (CPRF) and the ZTH toroidal, reversed-field-pinch (RFP), plasma physics experiment. The CPRF is a facility which will provide the buildings, utilities, pulsed power system, control system and diagnostics needed to operate a magnetically confined fusion experiment, and ZTH will be the first experiment operated in the facility. The construction of CPRF/ZTH is scheduled for completion in the first quarter of 1993. 5 figs

  18. Public Facilities Management and Action Research for Sustainability

    DEFF Research Database (Denmark)

    Galamba, Kirsten Ramskov

    Current work is the main product of a PhD study with the initial working title ‘Sustainable Facilities Management’ at Centre for Facilities Management – Realdania Research, DTU Management 1. December 2008 – 30. November 2011. Here the notion of Public Sustainable Facilities Management (FM......) is analysed in the light of a change process in a Danish Municipal Department of Public Property. Three years of Action Research has given a unique insight in the reality in a Municipal Department of Public Property, and as to how a facilitated change process can lead to a more holistic and sustainable...

  19. Research and test facilities required in nuclear science and technology

    International Nuclear Information System (INIS)

    2009-01-01

    Experimental facilities are essential research tools both for the development of nuclear science and technology and for testing systems and materials which are currently being used or will be used in the future. As a result of economic pressures and the closure of older facilities, there are concerns that the ability to undertake the research necessary to maintain and to develop nuclear science and technology may be in jeopardy. An NEA expert group with representation from ten member countries, the International Atomic Energy Agency and the European Commission has reviewed the status of those research and test facilities of interest to the NEA Nuclear Science Committee. They include facilities relating to nuclear data measurement, reactor development, neutron scattering, neutron radiography, accelerator-driven systems, transmutation, nuclear fuel, materials, safety, radiochemistry, partitioning and nuclear process heat for hydrogen production. This report contains the expert group's detailed assessment of the current status of these nuclear research facilities and makes recommendations on how future developments in the field can be secured through the provision of high-quality, modern facilities. It also describes the online database which has been established by the expert group which includes more than 700 facilities. (authors)

  20. Decontamination Technology Development for Nuclear Research Facilities

    International Nuclear Information System (INIS)

    Choi, W. K.; Jung, C. H.; Oh, W. Z.

    2007-06-01

    The originative CO 2 pellet blasting equipment was developed by improving additional components such as feed screw, idle roller and air-lock feeder to clear up the problems of freezing and discontinuity of blasting and by adopting pneumatically operated vacuum suction head and vacuum cup to prevent recontamination by collecting contaminant particulates simultaneously with the decontamination. The optimum decontamination process was established according to the kind of materials such as metal, concrete and plastic and the type of contaminants such as particulate, fixed chemical compound and oil. An excellent decontamination performances were verified by means of the lab-scale hot test with radioactive specimen and the technology demonstration in IMEF hot cell. The PFC dry decontamination equipment applicable to the surface contaminated with high radioactive particulate was developed. This equipment consists of the unit processes such as spray, collection, filtration and dry distillation designed originatively applicable to inside of dry hot cell. Through the demonstration of PFC spray decontamination process in IMEF hot cell, we secured on-site applicability and the decontamination efficiency more than 90 %. We investigated the characteristics of dismantled metal waste melting and the radionuclide(Co, Cs, U) distribution into ingot and slag by melting decontamination experiments using electric arc melter. We obtained the decontamination factors greater than 100 for Cs and of 10∼100 for uranium. The pilot scale(200 kg/batch) demonstration for melting decontamination was carried out successfully using high temperature melting facility at KAERI. The volume reduction factor of 1/7 and the economical feasibility of the melting decontamination were verified.

  1. ARM Climate Research Facility Annual Report 2004

    Energy Technology Data Exchange (ETDEWEB)

    Voyles, J.

    2004-12-31

    Like a rock that slowly wears away beneath the pressure of a waterfall, planet earth?s climate is almost imperceptibly changing. Glaciers are getting smaller, droughts are lasting longer, and extreme weather events like fires, floods, and tornadoes are occurring with greater frequency. Why? Part of the answer is clouds and the amount of solar radiation they reflect or absorb. These two factors clouds and radiative transfer represent the greatest source of error and uncertainty in the current generation of general circulation models used for climate research and simulation. The U.S. Global Change Research Act of 1990 established an interagency program within the Executive Office of the President to coordinate U.S. agency-sponsored scientific research designed to monitor, understand, and predict changes in the global environment. To address the need for new research on clouds and radiation, the U.S. Department of Energy (DOE) established the Atmospheric Radiation Measurement (ARM) Program. As part of the DOE?s overall Climate Change Science Program, a primary objective of the ARM Program is improved scientific understanding of the fundamental physics related to interactions between clouds and radiative feedback processes in the atmosphere.

  2. Leak testing requirements at a research facility

    International Nuclear Information System (INIS)

    Conner, J.B.

    1979-01-01

    Since September, 1952, Lawrence Livermore Laboratory has conducted pioneering research in applied science. A vital part of this activity has been the development of a variety of high vacuum and ultrahigh vacuum systems. Leaks occur in everything, including vacuum systems. The mass spectrometer leak detection equipment is described

  3. WormBase 2016: expanding to enable helminth genomic research.

    Science.gov (United States)

    Howe, Kevin L; Bolt, Bruce J; Cain, Scott; Chan, Juancarlos; Chen, Wen J; Davis, Paul; Done, James; Down, Thomas; Gao, Sibyl; Grove, Christian; Harris, Todd W; Kishore, Ranjana; Lee, Raymond; Lomax, Jane; Li, Yuling; Muller, Hans-Michael; Nakamura, Cecilia; Nuin, Paulo; Paulini, Michael; Raciti, Daniela; Schindelman, Gary; Stanley, Eleanor; Tuli, Mary Ann; Van Auken, Kimberly; Wang, Daniel; Wang, Xiaodong; Williams, Gary; Wright, Adam; Yook, Karen; Berriman, Matthew; Kersey, Paul; Schedl, Tim; Stein, Lincoln; Sternberg, Paul W

    2016-01-04

    WormBase (www.wormbase.org) is a central repository for research data on the biology, genetics and genomics of Caenorhabditis elegans and other nematodes. The project has evolved from its original remit to collect and integrate all data for a single species, and now extends to numerous nematodes, ranging from evolutionary comparators of C. elegans to parasitic species that threaten plant, animal and human health. Research activity using C. elegans as a model system is as vibrant as ever, and we have created new tools for community curation in response to the ever-increasing volume and complexity of data. To better allow users to navigate their way through these data, we have made a number of improvements to our main website, including new tools for browsing genomic features and ontology annotations. Finally, we have developed a new portal for parasitic worm genomes. WormBase ParaSite (parasite.wormbase.org) contains all publicly available nematode and platyhelminth annotated genome sequences, and is designed specifically to support helminth genomic research. © The Author(s) 2015. Published by Oxford University Press on behalf of Nucleic Acids Research.

  4. Progress report concerning safety research for nuclear reactor facilities

    International Nuclear Information System (INIS)

    1978-01-01

    Examination and evaluation of safety research results for nuclear reactor facilities have been performed, as more than a year has elapsed since the plan had been initiated in April, 1976, by the special sub-committee for the safety of nuclear reactor facilities. The research is carried out by being divided roughly into 7 items, and seems to be steadily proceeding, though it does not yet reach the target. The above 7 items include researches for (1) criticality accident, (2) loss of coolant accident, (3) safety for light water reactor fuel, (4) construction safety for reactor facilities, (5) reduction of release of radioactive material, (6) safety evaluation based on the probability theory for reactor facilities, and (7) aseismatic measures for reactor facilities. With discussions on the progress and the results of the research this time, research on the behaviour on fuel in abnormal transients including in-core and out-core experiments has been added to the third item, deleting the power-cooling mismatch experiment in Nuclear Safety Research Reactor of JAERI. Also it has been decided to add two research to the seventh item, namely measured data collection, classification and analysis, and probability assessment of failures due to an earthquake. For these 7 items, the report describes the concrete contents of research to be performed in fiscal years of 1977 and 1978, by discussing on most rational and suitable contents conceivable at present. (Wakatsuki, Y.)

  5. Design study of underground facility of the Underground Research Laboratory

    International Nuclear Information System (INIS)

    Hibiya, Keisuke; Akiyoshi, Kenji; Ishizuka, Mineo; Anezaki, Susumu

    1998-03-01

    Geoscientific research program to study deep geological environment has been performed by Power Reactor and Nuclear Fuel Development Corporation (PNC). This research is supported by 'Long-Term Program for Research, Development and Utilization of Nuclear Energy'. An Underground Research Laboratory is planned to be constructed at Shoma-sama Hora in the research area belonging to PNC. A wide range of geoscientific research and development activities which have been previously studied at the Tono Area is planned in the laboratory. The Underground Research Laboratory is consisted of Surface Laboratory and Underground Research Facility located from the surface down to depth between several hundreds and 1,000 meters. Based on the results of design study in last year, the design study performed in this year is to investigate the followings in advance of studies for basic design and practical design: concept, design procedure, design flow and total layout. As a study for the concept of the underground facility, items required for the facility are investigated and factors to design the primary form of the underground facility are extracted. Continuously, design methods for the vault and the underground facility are summarized. Furthermore, design procedures of the extracted factors are summarized and total layout is studied considering the results to be obtained from the laboratory. (author)

  6. Dispersion fuel for nuclear research facilities

    International Nuclear Information System (INIS)

    Kushtym, A.V.; Belash, M.M.; Zigunov, V.V.; Slabospitska, O.O.; Zuyok, V.A.

    2017-01-01

    Designs and process flow sheets for production of nuclear fuel rod elements and assemblies TVS-XD with dispersion composition UO_2+Al are presented. The results of fuel rod thermal calculation applied to Kharkiv subcritical assembly and Kyiv research reactor VVR-M, comparative characteristics of these fuel elements, the results of metallographic analyses and corrosion tests of fuel pellets are given in this paper

  7. Nuclear Safety Research and Facilities Department. Annual report 1999

    Energy Technology Data Exchange (ETDEWEB)

    Majborn, B.; Damkjaer, A.; Hedemann Jensen, P.; Nielsen, S.P.; Nonboel, E. [eds.

    2000-04-01

    The report presents a summary of the work of the Nuclear Safety Research and Facilities Department in 1999. The department's research and development activities were organized in two research programmes: 'Radiation Protection and Reactor Safety' and 'Radioecology and Tracer Studies'. The nuclear facilities operated by the department include the research reactor DR 3, the Isotope Laboratory, the Waste Management Plant, and the educational reactor DR 1. Lists of staff and publications are included together with a summary of the staff's participation in national and international committees. (au)

  8. Nuclear Safety Research and Facilities Department annual report 1999

    DEFF Research Database (Denmark)

    Majborn, B.; Damkjær, A.; Jensen, Per Hedemann

    2000-01-01

    The report presents a summary of the work of the Nuclear Safety Research and Facilities Department in 1999. The department´s research and development activities were organized in two research programmes: "Radiation Protection and Reactor Safety" and"Radioecology and Tracer Studies". The nuclear...... facilities operated by the department include the research reactor DR 3, the Isotope Laboratory, the Waste Management Plant, and the educational reactor DR 1. Lists of staff and publications are includedtogether with a summary of the staff´s participation in national and international committees....

  9. Nuclear Safety Research and Facilities Department annual report 1997

    Energy Technology Data Exchange (ETDEWEB)

    Majborn, B.; Aarkrog, A.; Brodersen, K. [and others

    1998-04-01

    The report presents a summary of the work of the Nuclear Safety Research and Facilities Department in 1997. The department`s research and development activities were organized in four research programmes: Reactor Safety, Radiation protection, Radioecology, and Radioanalytical Chemistry. The nuclear facilities operated by the department include the research reactor DR3, the Isotope Laboratory, the Waste Treatment Plant, and the educational reactor DR1. Lists of staff and publications are included together with a summary of the staff`s participation in national and international committees. (au) 11 tabs., 39 ills.; 74 refs.

  10. Nuclear Safety Research and Facilities Department annual report 1998

    Energy Technology Data Exchange (ETDEWEB)

    Majborn, B.; Brodersen, K.; Damkjaer, A.; Hedemann Jensen, P.; Nielsen, S.P.; Nonboel, E

    1999-04-01

    The report present a summary of the work of the Nuclear Safety Research and Facilities Department in 1998. The department`s research and development activities were organized in two research programmes: `Radiation Protection and Reactor Safety` and `Radioecology and Tracer Studies`. The nuclear facilities operated by the department include the research reactor DR3, the Isotope Laboratory, the Waste Treatment plant, and the educational reactor DR1. Lsits of staff and publications are included together with a summary of the staff`s participation in national and international committees. (au)

  11. Nuclear Safety Research and Facilities Department. Annual report 1999

    International Nuclear Information System (INIS)

    Majborn, B.; Damkjaer, A.; Hedemann Jensen, P.; Nielsen, S.P.; Nonboel, E.

    2000-04-01

    The report presents a summary of the work of the Nuclear Safety Research and Facilities Department in 1999. The department's research and development activities were organized in two research programmes: 'Radiation Protection and Reactor Safety' and 'Radioecology and Tracer Studies'. The nuclear facilities operated by the department include the research reactor DR 3, the Isotope Laboratory, the Waste Management Plant, and the educational reactor DR 1. Lists of staff and publications are included together with a summary of the staff's participation in national and international committees. (au)

  12. Nuclear Safety Research and Facilities department annual report 1996

    International Nuclear Information System (INIS)

    Majborn, B.; Brodersen, K.; Damkjaer, A.; Floto, H.; Heydorn, K.; Oelgaard, P.L.

    1997-04-01

    The report presents a summary of the work of the Nuclear Safety Research and Facilities Department in 1996. The Department's research and development activities are organized in three research programmes: Radiation Protection, Reactor Safety, and Radioanalytical Chemistry. The nuclear facilities operated by the department include the Research Reactor DR3, the Isotope Laboratory, the Waste Treatment Plant, and the Educational Reactor DR1. Lists of staff and publications are included together with a summary of the staff's participation in national and international committees. (au) 2 tabs., 28 ills

  13. Nuclear Safety Research and Facilities Department annual report 1997

    International Nuclear Information System (INIS)

    Majborn, B.; Aarkrog, A.; Brodersen, K.

    1998-04-01

    The report presents a summary of the work of the Nuclear Safety Research and Facilities Department in 1997. The department's research and development activities were organized in four research programmes: Reactor Safety, Radiation protection, Radioecology, and Radioanalytical Chemistry. The nuclear facilities operated by the department include the research reactor DR3, the Isotope Laboratory, the Waste Treatment Plant, and the educational reactor DR1. Lists of staff and publications are included together with a summary of the staff's participation in national and international committees. (au)

  14. Nuclear Safety Research and Facilities Department annual report 1998

    International Nuclear Information System (INIS)

    Majborn, B.; Brodersen, K.; Damkjaer, A.; Hedemann Jensen, P.; Nielsen, S.P.; Nonboel, E.

    1999-04-01

    The report present a summary of the work of the Nuclear Safety Research and Facilities Department in 1998. The department's research and development activities were organized in two research programmes: 'Radiation Protection and Reactor Safety' and 'Radioecology and Tracer Studies'. The nuclear facilities operated by the department include the research reactor DR3, the Isotope Laboratory, the Waste Treatment plant, and the educational reactor DR1. Lsits of staff and publications are included together with a summary of the staff's participation in national and international committees. (au)

  15. The Safety and Tritium Applied Research (STAR) Facility: Status-2004

    International Nuclear Information System (INIS)

    Anderl, R.A.; Longhurst, G.R.; Pawelko, R.J.; Sharpe, J.P.; Schuetz, S.T.; Petti, D.A.

    2005-01-01

    The Safety and Tritium Applied Research (STAR) Facility, a US DOE National User Facility at the Idaho National Engineering and Environmental Laboratory (INEEL), comprises capabilities and infrastructure to support both tritium and non-tritium research activities important to the development of safe and environmentally friendly fusion energy. Research thrusts include (1) interactions of tritium and deuterium with plasma-facing-component (PFC) materials, (2) fusion safety issues [PFC material chemical reactivity and dust/debris generation, activation product mobilization, tritium behavior in fusion systems], and (3) molten salts and fusion liquids for tritium breeder and coolant applications. This paper updates the status of STAR and the capabilities for ongoing research activities, with an emphasis on the development, testing and integration of the infrastructure to support tritium research activities. Key elements of this infrastructure include a tritium storage and assay system, a tritium cleanup system to process glovebox and experiment tritiated effluent gases, and facility tritium monitoring systems

  16. Genome editing in pluripotent stem cells: research and therapeutic applications

    Energy Technology Data Exchange (ETDEWEB)

    Deleidi, Michela, E-mail: michela.deleidi@dzne.de [German Center for Neurodegenerative Diseases (DZNE) Tübingen within the Helmholtz Association, Tübingen (Germany); Hertie Institute for Clinical Brain Research, University of Tübingen (Germany); Yu, Cong [Department of Microbiology and Immunology, School of Medicine and Biomedical Sciences, University at Buffalo, New York (United States)

    2016-05-06

    Recent progress in human pluripotent stem cell (hPSC) and genome editing technologies has opened up new avenues for the investigation of human biology in health and disease as well as the development of therapeutic applications. Gene editing approaches with programmable nucleases have been successfully established in hPSCs and applied to study gene function, develop novel animal models and perform genetic and chemical screens. Several studies now show the successful editing of disease-linked alleles in somatic and patient-derived induced pluripotent stem cells (iPSCs) as well as in animal models. Importantly, initial clinical trials have shown the safety of programmable nucleases for ex vivo somatic gene therapy. In this context, the unlimited proliferation potential and the pluripotent properties of iPSCs may offer advantages for gene targeting approaches. However, many technical and safety issues still need to be addressed before genome-edited iPSCs are translated into the clinical setting. Here, we provide an overview of the available genome editing systems and discuss opportunities and perspectives for their application in basic research and clinical practice, with a particular focus on hPSC based research and gene therapy approaches. Finally, we discuss recent research on human germline genome editing and its social and ethical implications. - Highlights: • Programmable nucleases have proven efficient and specific for genome editing in human pluripotent stem cells (hPSCs). • Genome edited hPSCs can be employed to study gene function in health and disease as well as drug and chemical screens. • Genome edited hPSCs hold great promise for ex vivo gene therapy approaches. • Technical and safety issues should be first addressed to advance the clinical use of gene-edited hPSCs.

  17. Genome editing in pluripotent stem cells: research and therapeutic applications

    International Nuclear Information System (INIS)

    Deleidi, Michela; Yu, Cong

    2016-01-01

    Recent progress in human pluripotent stem cell (hPSC) and genome editing technologies has opened up new avenues for the investigation of human biology in health and disease as well as the development of therapeutic applications. Gene editing approaches with programmable nucleases have been successfully established in hPSCs and applied to study gene function, develop novel animal models and perform genetic and chemical screens. Several studies now show the successful editing of disease-linked alleles in somatic and patient-derived induced pluripotent stem cells (iPSCs) as well as in animal models. Importantly, initial clinical trials have shown the safety of programmable nucleases for ex vivo somatic gene therapy. In this context, the unlimited proliferation potential and the pluripotent properties of iPSCs may offer advantages for gene targeting approaches. However, many technical and safety issues still need to be addressed before genome-edited iPSCs are translated into the clinical setting. Here, we provide an overview of the available genome editing systems and discuss opportunities and perspectives for their application in basic research and clinical practice, with a particular focus on hPSC based research and gene therapy approaches. Finally, we discuss recent research on human germline genome editing and its social and ethical implications. - Highlights: • Programmable nucleases have proven efficient and specific for genome editing in human pluripotent stem cells (hPSCs). • Genome edited hPSCs can be employed to study gene function in health and disease as well as drug and chemical screens. • Genome edited hPSCs hold great promise for ex vivo gene therapy approaches. • Technical and safety issues should be first addressed to advance the clinical use of gene-edited hPSCs.

  18. Animal welfare strengthens the quality of research. 3 million euros for a ultramodern animal facility

    International Nuclear Information System (INIS)

    2015-01-01

    The Belgian Nuclear Research Center SCK-CEN has been studying the long-term effects of low radiation doses on health for over 40 years.This uses mice because more than 90 per cent of their genome is identical with that of human beings. In order to work better and more ethically, SCK-CEN has invested 3 million euros in a brand-new animal facility. This makes it possible to carry out research under the best possible conditions for both humans and mice.

  19. Balancing the risks and benefits of genomic data sharing: genome research participants' perspectives.

    Science.gov (United States)

    Oliver, J M; Slashinski, M J; Wang, T; Kelly, P A; Hilsenbeck, S G; McGuire, A L

    2012-01-01

    Technological advancements are rapidly propelling the field of genome research forward, while lawmakers attempt to keep apace with the risks these advances bear. Balancing normative concerns of maximizing data utility and protecting human subjects, whose privacy is at risk due to the identifiability of DNA data, are central to policy decisions. Research on genome research participants making real-time data sharing decisions is limited; yet, these perspectives could provide critical information to ongoing deliberations. We conducted a randomized trial of 3 consent types affording varying levels of control over data release decisions. After debriefing participants about the randomization process, we invited them to a follow-up interview to assess their attitudes toward genetic research, privacy and data sharing. Participants were more restrictive in their reported data sharing preferences than in their actual data sharing decisions. They saw both benefits and risks associated with sharing their genomic data, but risks were seen as less concrete or happening in the future, and were largely outweighed by purported benefits. Policymakers must respect that participants' assessment of the risks and benefits of data sharing and their privacy-utility determinations, which are associated with their final data release decisions, vary. In order to advance the ethical conduct of genome research, proposed policy changes should carefully consider these stakeholder perspectives. Copyright © 2011 S. Karger AG, Basel.

  20. Progress towards a new Canadian irradiation-research facility

    International Nuclear Information System (INIS)

    Lee, A.G.; Lidstone, R.F.

    1993-01-01

    As reported at the second meeting of the International Group on Research Reactors, Atomic Energy of Canada Limited (AECL) is evaluating its options for future irradiation facilities. During the past year significant progress has been made towards achieving consensus on the irradiation requirements for AECL's major research programs and interpreting those requirements in terms of desirable characteristics for experimental facilities in a research reactor. The next stage of the study involves identifying near-term and long-term options for irradiation-research facilities to meet the requirements. The near-term options include assessing the availability of the NRU reactor and the capabilities of existing research reactors. The long-term options include developing a new irradiation-research facility by adapting the technology base for the MAPLE-X10 reactor design. Because materials testing in support of CANDU power reactors dominates AECL's irradiation requirements, the new reactor concept is called the MAPLE Materials Testing Reactor (MAPLE-MTR). Parametric physics and engineering studies are in progress on alternative MAPLE-MTR configurations to assess the capabilities for the following types of test facilities: - fast-neutron sites, that accommodate materials-irradiation assemblies, - small-diameter vertical fuel test loops that accommodate multielement assemblies, - large-diameter vertical fuel test loops, each able to hold one or more CANDU fuel bundles, - horizontal test loops, each able to hold full-size CANDU fuel bundles or small-diameter multi-element assemblies, and - horizontal beam tubes

  1. Combining genomic and proteomic approaches for epigenetics research

    Science.gov (United States)

    Han, Yumiao; Garcia, Benjamin A

    2014-01-01

    Epigenetics is the study of changes in gene expression or cellular phenotype that do not change the DNA sequence. In this review, current methods, both genomic and proteomic, associated with epigenetics research are discussed. Among them, chromatin immunoprecipitation (ChIP) followed by sequencing and other ChIP-based techniques are powerful techniques for genome-wide profiling of DNA-binding proteins, histone post-translational modifications or nucleosome positions. However, mass spectrometry-based proteomics is increasingly being used in functional biological studies and has proved to be an indispensable tool to characterize histone modifications, as well as DNA–protein and protein–protein interactions. With the development of genomic and proteomic approaches, combination of ChIP and mass spectrometry has the potential to expand our knowledge of epigenetics research to a higher level. PMID:23895656

  2. Genome typing of nonhuman primate models: implications for biomedical research.

    Science.gov (United States)

    Haus, Tanja; Ferguson, Betsy; Rogers, Jeffrey; Doxiadis, Gaby; Certa, Ulrich; Rose, Nicola J; Teepe, Robert; Weinbauer, Gerhard F; Roos, Christian

    2014-11-01

    The success of personalized medicine rests on understanding the genetic variation between individuals. Thus, as medical practice evolves and variation among individuals becomes a fundamental aspect of clinical medicine, a thorough consideration of the genetic and genomic information concerning the animals used as models in biomedical research also becomes critical. In particular, nonhuman primates (NHPs) offer great promise as models for many aspects of human health and disease. These are outbred species exhibiting substantial levels of genetic variation; however, understanding of the contribution of this variation to phenotypes is lagging behind in NHP species. Thus, there is a pivotal need to address this gap and define strategies for characterizing both genomic content and variability within primate models of human disease. Here, we discuss the current state of genomics of NHP models and offer guidelines for future work to ensure continued improvement and utility of this line of biomedical research. Copyright © 2014 Elsevier Ltd. All rights reserved.

  3. Radiation monitoring in high energy research facility

    International Nuclear Information System (INIS)

    Miyajima, Mitsuhiro

    1975-01-01

    In High Energy Physics Research Laboratory, construction of high energy proton accelerator is in progress. The accelerator is a cascaded machine comprising Cockcroft type (50 keV), linac (20 MeV), booster synchrotron (500 MeV), and synchrotron (8-12 GeV). Its proton beam intensity is 1x10 13 photons/pulse, and acceleration is carried out at the rate of every 2 minutes. The essential problems of radiation control in high energy accelerators are those of various radiations generated secondarily by proton beam and a number of induced radiations simultaneously originated with such secondary particles. In the Laboratory, controlled areas are divided into color-coded four regions, red, orange, yellow and green, based on each dose-rate. BF 3 counters covered with thick paraffin are used as neutron detectors, and side-window GM tubes, NaI (Tl) scintillators and ionization chambers as γ-detectors. In red region, however, ionization chambers are applied to induced radiation detection, and neutrons are not monitored. NIM standards are adopted for the circuits of all above monitors considering easy maintenance, economy and interchangeability. Notwithstanding the above described systems, these monitors are not sufficient to complete the measurement of whole radiations over wide energy region radiated from the accelerators. Hence separate radiation field measurement is required periodically. An example of the monitoring systems in National Accelerator Laboratory (U.S.) is referred at the last section. (Wakatsuki, Y.)

  4. Decommissioning Technology Development for Nuclear Research Facilities

    International Nuclear Information System (INIS)

    Lee, K. W.; Kang, Y. A.; Kim, G. H.

    2007-06-01

    It is predicted that the decommissioning of a nuclear power plant would happen in Korea since 2020 but the need of partial decommissioning and decontamination for periodic inspection and life extension still has been on an increasing trend and its domestic market has gradually been extended. Therefore, in this project we developed following several essential technologies as a decommissioning R and D. The measurement technology for in-pipe radioactive contamination was developed for measuring alpha/beta/gamma emitting nuclides simultaneously inside a in-pipe and it was tested into the liquid waste transfer pipe in KRR-2. And the digital mock-up system for KRR-1 and 2 was developed for choosing the best scenarios among several scenarios on the basis of various decommissioning information(schedule, waste volume, cost, etc.) that are from the DMU and the methodology of decommissioning cost estimation was also developed for estimating a research reactor's decommissioning cost and the DMU and the decommissioning cost estimation system were incorporated into the decommissioning information integrated management system. Finally the treatment and management technology of the irradiated graphites that happened after decommissioning KRR-2 was developed in order to treat and manage the irradiated graphites safely

  5. Decommissioning Technology Development for Nuclear Research Facilities

    Energy Technology Data Exchange (ETDEWEB)

    Lee, K. W.; Kang, Y. A.; Kim, G. H. (and others)

    2007-06-15

    It is predicted that the decommissioning of a nuclear power plant would happen in Korea since 2020 but the need of partial decommissioning and decontamination for periodic inspection and life extension still has been on an increasing trend and its domestic market has gradually been extended. Therefore, in this project we developed following several essential technologies as a decommissioning R and D. The measurement technology for in-pipe radioactive contamination was developed for measuring alpha/beta/gamma emitting nuclides simultaneously inside a in-pipe and it was tested into the liquid waste transfer pipe in KRR-2. And the digital mock-up system for KRR-1 and 2 was developed for choosing the best scenarios among several scenarios on the basis of various decommissioning information(schedule, waste volume, cost, etc.) that are from the DMU and the methodology of decommissioning cost estimation was also developed for estimating a research reactor's decommissioning cost and the DMU and the decommissioning cost estimation system were incorporated into the decommissioning information integrated management system. Finally the treatment and management technology of the irradiated graphites that happened after decommissioning KRR-2 was developed in order to treat and manage the irradiated graphites safely.

  6. Irradiation Facilities of the Takasaki Advanced Radiation Research Institute

    Directory of Open Access Journals (Sweden)

    Satoshi Kurashima

    2017-03-01

    Full Text Available The ion beam facility at the Takasaki Advanced Radiation Research Institute, the National Institutes for Quantum and Radiological Science and Technology, consists of a cyclotron and three electrostatic accelerators, and they are dedicated to studies of materials science and bio-technology. The paper reviews this unique accelerator complex in detail from the viewpoint of its configuration, accelerator specification, typical accelerator, or irradiation technologies and ion beam applications. The institute has also irradiation facilities for electron beams and 60Co gamma-rays and has been leading research and development of radiation chemistry for industrial applications in Japan with the facilities since its establishment. The configuration and utilization of those facilities are outlined as well.

  7. Radwaste requirements at a biomedical research facility

    International Nuclear Information System (INIS)

    Brannegan, D.P.; Wolter, W.; Merenda, J.M.; Figdor, S.K.

    1993-01-01

    The low-level radioactive waste (LLRW) federal legislation that was passed during the 1980s was intended to provide an orderly system of LLRW disposal as the country's three waste sites proceeded toward excluding out-of-state generators. The system was based on a regional interstate compact system. As originally envisioned, several contiguous states were to form an association (compact) with one state receiving radwaste from the compact. Everyone is aware of the difficulties that followed as attempts were made to implement these laws and to meet the prescribed milestones to avoid financial penalties. Although the states (compacts) have labored for over 12 yr along this rocky road, no compact has developed and licensed a new disposal site prior to the January 1, 1993 deadline. A recent report by the Center for the Study of American Business at Washington University in St. Louis states that open-quotes The current regional interstate compact system for disposal of low-level radioactive waste is fatally flawed on both technical and practical political grounds.close quotes Thus, the system has broken down and the three original LLRW sites closed their gates (with the possible exception of Barnwell) as planned on January 1, 1993. It would appear that the fate of LLRW will be the same as that of high-level waste (HLW); it will be stored at the site of the generator until a solution to the problem is found. For the nonutility generator, storage is an entirely new problem. It must be appreciated that almost all nonutility generators are in the business of research or medical treatment and not in the business of storing LLRW. Thus, storage represents a new turn of events and a new aspect of doing business. It also means the diversion of limited resources to a problem that should not exist. Lastly, on-site LLRW storage for the nonutility generator will also require additional regulatory approval for the handling, storage, and ongoing monitoring of this waste

  8. Remote operations in a Fusion Engineering Research Facility (FERF)

    International Nuclear Information System (INIS)

    Doggett, J.N.

    1975-01-01

    The proposed Fusion Engineering Research Facility (FERF) has been designed for the test and evaluation of materials that will be exposed to the hostile radiation environment created by fusion reactors. Because the FERF itself must create a very hostile radiation environment, extensive remote handling procedures will be required as part of its routine operations as well as for both scheduled and unscheduled maintenance. This report analyzes the remote-handling implications of a vertical- rather than horizontal-orientation of the FERF magnet, describes the specific remote-handling facilities of the proposed FERF installation and compares the FERF remote-handling system with several other existing and proposed facilities. (U.S.)

  9. A new facility for advanced rocket propulsion research

    Science.gov (United States)

    Zoeckler, Joseph G.; Green, James M.; Raitano, Paul

    1993-06-01

    A new test facility was constructed at the NASA Lewis Research Center Rocket Laboratory for the purpose of conducting rocket propulsion research at up to 8.9 kN (2000 lbf) thrust, using liquid oxygen and gaseous hydrogen propellants. A laser room adjacent to the test cell provides access to the rocket engine for advanced laser diagnostic systems. The size and location of the test cell provide the ability to conduct large amounts of testing in short time periods, with rapid turnover between programs. These capabilities make the new test facility an important asset for basic and applied rocket propulsion research.

  10. A safety decision analysis for Saudi Arabian nuclear research facility

    International Nuclear Information System (INIS)

    Abulfaraj, W.H.; Abdul-Fattah, A.F.

    1985-01-01

    Establishment of a nuclear research facility should be the first step in planning for introducing the nuclear energy to Saudi Arabia. The fuzzy set decision theory is selected among different decision theories to be applied for this analysis. Four research reactors from USA are selected for the present study. The IFDA computer code, based on the fuzzy set theory is applied. Results reveal that the FNR reactor is the best alternative for the case of Saudi Arabian nuclear research facility, and MITR is the second best. 17 refs

  11. Seven layers of security to help protect biomedical research facilities.

    Science.gov (United States)

    Mortell, Norman

    2010-04-01

    In addition to risks such as theft and fire that can confront any type of business, the biomedical research community often faces additional concerns over animal rights extremists, infiltrations, data security and intellectual property rights. Given these concerns, it is not surprising that the industry gives a high priority to security. This article identifies security threats faced by biomedical research companies and shows how these threats are ranked in importance by industry stakeholders. The author then goes on to discuss seven key 'layers' of security, from the external environment to the research facility itself, and how these layers all contribute to the creation of a successfully secured facility.

  12. 76 FR 65204 - National Human Genome Research Institute; Notice of Closed Meetings

    Science.gov (United States)

    2011-10-20

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Human Genome... constitute a clearly unwarranted invasion of personal privacy. Name of Committee: National Human Genome... Review Officer, Scientific Review Branch, National Human Genome Research Institute, 5635 Fishers Lane...

  13. 77 FR 12604 - National Human Genome Research Institute; Notice of Closed Meetings

    Science.gov (United States)

    2012-03-01

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Human Genome... clearly unwarranted invasion of personal privacy. >Name of Committee: National Human Genome Research... review and evaluate contract proposals. Place: National Human Genome Reseach Institute, 5635 Fishers Lane...

  14. Parallel computing in genomic research: advances and applications

    Directory of Open Access Journals (Sweden)

    Ocaña K

    2015-11-01

    Full Text Available Kary Ocaña,1 Daniel de Oliveira2 1National Laboratory of Scientific Computing, Petrópolis, Rio de Janeiro, 2Institute of Computing, Fluminense Federal University, Niterói, Brazil Abstract: Today's genomic experiments have to process the so-called "biological big data" that is now reaching the size of Terabytes and Petabytes. To process this huge amount of data, scientists may require weeks or months if they use their own workstations. Parallelism techniques and high-performance computing (HPC environments can be applied for reducing the total processing time and to ease the management, treatment, and analyses of this data. However, running bioinformatics experiments in HPC environments such as clouds, grids, clusters, and graphics processing unit requires the expertise from scientists to integrate computational, biological, and mathematical techniques and technologies. Several solutions have already been proposed to allow scientists for processing their genomic experiments using HPC capabilities and parallelism techniques. This article brings a systematic review of literature that surveys the most recently published research involving genomics and parallel computing. Our objective is to gather the main characteristics, benefits, and challenges that can be considered by scientists when running their genomic experiments to benefit from parallelism techniques and HPC capabilities. Keywords: high-performance computing, genomic research, cloud computing, grid computing, cluster computing, parallel computing

  15. Facilities for Research and Development of Medical Radioisotopes

    International Nuclear Information System (INIS)

    Shin, Byung Chul; Choung, Won Myung; Park, Jin Ho

    2003-03-01

    This study is carried out by KAERI(Korea Atomic Energy Research Institute) to construct the basic facilities for development and production of medical radioisotope. For the characteristics of radiopharmaceuticals, the facilities should be complied with the radiation shield and GMP(Good Manufacturing Practice) guideline. The KAERI, which has carried out the research and development of the radiopharmaceuticals, made a design of these facilities and built them in the HANARO Center and opened the technique and facilities to the public to give a foundation for research and development of the radiopharmaceuticals. In the facilities, radiation shielding utilities and GMP instruments were set up and their operating manuals were documented. Every utilities and instruments were performed the test to confirm their efficiency and the approval for use of the facilities will be achieved from MOST(Ministry of Science and Technology). It is expected to be applied in development of therapeutic radioisotope such as Re-188 generator and Ho-166, as well as Tc-99m generator and Sr-89 chloride for medical use. And it also looks forward to the contribution to the related industry through the development of product in high demand and value

  16. Space facilities: Meeting future needs for research, development, and operations

    Science.gov (United States)

    The National Facilities Study (NFS) represents an interagency effort to develop a comprehensive and integrated long-term plan for world-class aeronautical and space facilities that meet current and projected needs for commercial and government aerospace research and development and space operations. At the request of NASA and the DOD, the National Research Council's Committee on Space Facilities has reviewed the space related findings of the NFS. The inventory of more than 2800 facilities will be an important resource, especially if it continues to be updated and maintained as the NFS report recommends. The data in the inventory provide the basis for a much better understanding of the resources available in the national facilities infrastructure, as well as extensive information on which to base rational decisions about current and future facilities needs. The working groups have used the inventory data and other information to make a set of recommendations that include estimates of cast savings and steps for implementation. While it is natural that the NFS focused on cost reduction and consolidations, such a study is most useful to future planning if it gives equal weight to guiding the direction of future facilities needed to satisfy legitimate national aspirations. Even in the context of cost reduction through facilities closures and consolidations, the study is timid about recognizing and proposing program changes and realignments of roles and missions to capture what could be significant savings and increased effectiveness. The recommendations of the Committee on Space Facilities are driven by the clear need to be more realistic and precise both in recognizing current incentives and disincentives in the aerospace industry and in forecasting future conditions for U.S. space activities.

  17. Atmospheric Radiation Measurement (ARM) Climate Research Facility Management Plan

    Energy Technology Data Exchange (ETDEWEB)

    Mather, James [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2016-04-01

    Mission and Vision Statements for the U.S. Department of Energy (DOE)’s Atmospheric Radiation Measurement (ARM) Climate Research Facility Mission The ARM Climate Research Facility, a DOE scientific user facility, provides the climate research community with strategically located in situ and remote-sensing observatories designed to improve the understanding and representation, in climate and earth system models, of clouds and aerosols as well as their interactions and coupling with the Earth’s surface. Vision To provide a detailed and accurate description of the Earth atmosphere in diverse climate regimes to resolve the uncertainties in climate and Earth system models toward the development of sustainable solutions for the nation's energy and environmental challenges.

  18. FAIR - Facility, Research Program and Status of the Project

    International Nuclear Information System (INIS)

    Majka, Z.

    2011-01-01

    The international Facility for Antiproton and Ion Research (FAIR) in Europe will provide a worldwide science community with a unique and technically innovative accelerator system to perform forefront research in the sciences concerned with the basic structure of matter, and in intersections with other fields. The facility will deliver an extensive range of primary and secondary particle beams from protons and their antimatter partners, antiprotons, to ion beams of all chemical elements up to the heaviest, uranium, with in many respects unique properties and intensities. The paper will include overview of the new facility design and research programs to be carried out there. The current status of the FAIR project will be also presented. (author)

  19. Earthquake research for the safer siting of critical facilities

    Energy Technology Data Exchange (ETDEWEB)

    Cluff, J.L. (ed.)

    1980-01-01

    The task of providing the necessities for living, such as adequate electrical power, water, and fuel, is becoming more complicated with time. Some of the facilities that provide these necessities would present potential hazards to the population if serious damage were to occur to them during earthquakes. Other facilities must remain operable immediately after an earthquake to provide life-support services to people who have been affected. The purpose of this report is to recommend research that will improve the information available to those who must decide where to site these critical facilities, and thereby mitigate the effects of the earthquake hazard. The term critical facility is used in this report to describe facilities that could seriously affect the public well-being through loss of life, large financial loss, or degradation of the environment if they were to fail. The term critical facility also is used to refer to facilities that, although they pose a limited hazard to the public, are considered critical because they must continue to function in the event of a disaster so that they can provide vital services.

  20. The Whole Genome Assembly and Comparative Genomic Research of Thellungiella parvula (Extremophile Crucifer Mitochondrion

    Directory of Open Access Journals (Sweden)

    Xuelin Wang

    2016-01-01

    Full Text Available The complete nucleotide sequences of the mitochondrial (mt genome of an extremophile species Thellungiella parvula (T. parvula have been determined with the lengths of 255,773 bp. T. parvula mt genome is a circular sequence and contains 32 protein-coding genes, 19 tRNA genes, and three ribosomal RNA genes with a 11.5% coding sequence. The base composition of 27.5% A, 27.5% T, 22.7% C, and 22.3% G in descending order shows a slight bias of 55% AT. Fifty-three repeats were identified in the mitochondrial genome of T. parvula, including 24 direct repeats, 28 tandem repeats (TRs, and one palindromic repeat. Furthermore, a total of 199 perfect microsatellites have been mined with a high A/T content (83.1% through simple sequence repeat (SSR analysis and they were distributed unevenly within this mitochondrial genome. We also analyzed other plant mitochondrial genomes’ evolution in general, providing clues for the understanding of the evolution of organelles genomes in plants. Comparing with other Brassicaceae species, T. parvula is related to Arabidopsis thaliana whose characters of low temperature resistance have been well documented. This study will provide important genetic tools for other Brassicaceae species research and improve yields of economically important plants.

  1. In-pile experimental facility needs for LMFR safety research

    International Nuclear Information System (INIS)

    Kawata, Norio; Niwa, Hajime

    1994-01-01

    Although the achievement of the safety research during the past years has been significant, there still exists a strong need for future research, especially when there is prospect for future LMFR commercialization. In this paper, our current views are described on future research needs especially with a new in-pile experimental facility. The basic ideas and progress are outlined of a preliminary feasibility study. (author)

  2. New research facilities at the University of Missouri research reactor

    International Nuclear Information System (INIS)

    McKibben, J.C.; Rhyne, J.J.

    1992-01-01

    The University of Missouri-Columbia is investing its resources for a significant expansion of the research capabilities and utilization of MURR to provide it the opportunity to deliver on its obligation to become the nation's premier educational institution in nuclear-related fields and so that it can provide scientific personnel and a state-of-the-art research test bed to support the national need for highly trained graduates in nuclear science and engineering

  3. Genomic research with human samples. Points of view from scientists and research subjects about disclosure of results and risks of genomic research. Ethical and empirical approach.

    Science.gov (United States)

    Valle Mansilla, José Ignacio

    2011-01-01

    Biomedical researchers often now ask subjects to donate samples to be deposited in biobanks. This is not only of interest to researchers, patients and society as a whole can benefit from the improvements in diagnosis, treatment, and prevention that the advent of genomic medicine portends. However, there is a growing debate regarding the social and ethical implications of creating biobanks and using stored human tissue samples for genomic research. Our aim was to identify factors related to both scientists and patients' preferences regarding the sort of information to convey to subjects about the results of the study and the risks related to genomic research. The method used was a survey addressed to 204 scientists and 279 donors from the U.S. and Spain. In this sample, researchers had already published genomic epidemiology studies; and research subjects had actually volunteered to donate a human sample for genomic research. Concerning the results, patients supported more frequently than scientists their right to know individual results from future genomic research. These differences were statistically significant after adjusting by the opportunity to receive genetic research results from the research they had previously participated and their perception of risks regarding genetic information compared to other clinical data. A slight majority of researchers supported informing participants about individual genomic results only if the reliability and clinical validity of the information had been established. Men were more likely than women to believe that patients should be informed of research results even if these conditions were not met. Also among patients, almost half of them would always prefer to be informed about individual results from future genomic research. The three main factors associated to a higher support of a non-limited access to individual results were: being from the US, having previously been offered individual information and considering

  4. Decommissioning of small medical, industrial and research facilities

    International Nuclear Information System (INIS)

    2003-01-01

    Most of the technical literature on decommissioning addresses the regulatory, organizational, technical and other aspects for large facilities such as nuclear power plants, reprocessing plants and relatively large prototype, research and test reactors. There are, however, a much larger number of licensed users of radioactive material in the fields of medicine, research and industry. Most of these nuclear facilities are smaller in size and complexity and may present a lower radiological risk during their decommissioning. Such facilities are located at research establishments, biological and medical laboratories, universities, medical centres, and industrial and manufacturing premises. They are often operated by users who have not been trained or are unfamiliar with the decommissioning, waste management and associated safety aspects of these types of facility at the end of their operating lives. Also, for many small users of radioactive material such as radiation sources, nuclear applications are a small part of the overall business or process and, although the operating safety requirements may be adhered to, concern or responsibility may not go much beyond this. There is concern that even the minimum requirements of decommissioning may be disregarded, resulting in avoidable delays, risks and safety implications (e.g. a loss of radioactive material and a loss of all records). Incidents have occurred in which persons have been injured or put at risk. It is recognized that the strategies and specific requirements for small facilities may be much less onerous than for large ones such as nuclear power plants or fuel processing facilities, but many of the same principles apply. There has been considerable attention given to nuclear facilities and many IAEA publications are complementary to this report. This report, however, attempts to give specific guidance for small facilities. 'Small' in this report does not necessarily mean small in size but generally modest in terms

  5. Research Support Facility (RSF): Leadership in Building Performance (Brochure)

    Energy Technology Data Exchange (ETDEWEB)

    2011-09-01

    This brochure/poster provides information on the features of the Research Support Facility including a detailed illustration of the facility with call outs of energy efficiency and renewable energy technologies. Imagine an office building so energy efficient that its occupants consume only the amount of energy generated by renewable power on the building site. The building, the Research Support Facility (RSF) occupied by the U.S. Department of Energy's National Renewable Energy Laboratory (NREL) employees, uses 50% less energy than if it were built to current commercial code and achieves the U.S. Green Building Council's Leadership in Energy and Environmental Design (LEED{reg_sign}) Platinum rating. With 19% of the primary energy in the U.S. consumed by commercial buildings, the RSF is changing the way commercial office buildings are designed and built.

  6. Safety Research Experiment Facility Project. Conceptual design report. Volume II. Building and facilities

    International Nuclear Information System (INIS)

    1975-12-01

    The conceptual design of Safety Research Experiment Facility (SAREF) site system includes a review and evaluation of previous geotechnical reports for the area where SAREF will be constructed and the conceptual design of access and in-plant roads, parking, experiment-transport-vehicle maneuvering areas, security fencing, drainage, borrow area development and restoration, and landscaping

  7. Management and Development of the RT Research Facilities and Infrastructures

    International Nuclear Information System (INIS)

    Kim, Won Ho; Nho, Young Chang; Kim, Jae Sung

    2009-01-01

    The purpose of this project are to operate the core facilities of the research for the Radiation Technology in stable and to assist the research activities efficiently in the industry, academic, and research laboratory. By developing the infrastructure of the national radio technology industry, we can activate the researching area of the RT and the related industry, and obtain the primary and original technology. The key point in the study of the RT and the assistance of the industry, academic, and research laboratory for the RT area smoothly, is managing the various of unique radiation facilities in our country. The gamma Phytotron and Gene Bank are essential in the agribiology because these facilities are used to preserve and utilize the genes and to provide an experimental field for the environment and biotechnology. The Radiation Fusion Technology research supporting facilities are the core support facilities, and are used to develop the high-tech fusion areas. In addition, the most advanced analytical instruments, whose costs are very high, should be managed in stable and be utilized in supporting works, and the experimental animal supporting laboratory and Gamma Cell have to be maintained in high level and managed in stable also. The ARTI have been developed the 30MeV cyclotron during 2005∼2006, aimed to produce radioisotopes and to research the beam applications as a result of the project, 'Establishment of the Infrastructure for the Atomic Energy Research Expansion', collaborated with the Korea Institute of Radiological and Medical Sciences. In addition, the ARTI is in the progress of establishing cyclotron integrated complex as a core research facility, using a proton beam to produce radioisotopes and to support a various research areas. The measurement and evaluation of the irradiation dose, and irradiation supporting technology of the Good Irradiation Practice(GIP) are essential in various researching areas. One thing to remember is that the publicity

  8. The International Facility for Antiproton and Ion Research FAIR

    International Nuclear Information System (INIS)

    Gutbrod, H. H.

    2008-01-01

    The proposed project FAIR (Facility for Antiproton and Ion Research) is an international accelerator facility of the next generation and will be built as a new company FAIR GmbH next to the site of GSI. About 15 countries have expressed their intention to become shareholders. FAIR builds on the experience and technological developments already made at the existing GSI facility, and at the FAIR partner institutes world wide and incorporates new technological concepts. At its heart is a double ring facility with a circumference of 1100 meters. A system of cooler-storage rings for effective beam cooling at high energies and various experimental halls will be connected to the facility. The existing GSI accelerators - together with the planned proton-linac - serve as injector for the new facility. The double-ring synchrotron will provide ion beams of unprecedented intensities as well as of considerably increased energy. Thereby intense beams of secondary beams - unstable nuclei or antiprotons - can be produced. The system of storage-cooler rings allows the quality of these secondary beams - their energy spread and emittance - to be drastically improved. Moreover, in connection with the double ring synchrotron, an efficient parallel operation of up to four scientific programs can be realized at a time. The project is based on many technological innovations, the most important of which are five beam properties: Highest Beam Intensities, Brilliant Beam Quality, Higher Beam Energies, Highest Beam Power, Parallel Operation

  9. Electronic battlespace facility for research, develoment and engineering

    NARCIS (Netherlands)

    Jense, Hans; Kuijpers, N.H.L.; Elias, R.J.D.

    1997-01-01

    In order to support its research, development and engineering activities in the area of distributed simulation for training and command & control, TNO Physics and Electronics Laboratory has developed (and continues to enhance) an Electronic Battlespace Facility (EBF). This paper presents an overview

  10. Detailed description of an SSAC at the facility level for research laboratory facilities

    International Nuclear Information System (INIS)

    Jones, R.J.

    1985-08-01

    The purpose of this document is to provide a detailed description of a system for the accounting for and control of nuclear material in a research laboratory facility which can be used by a facility operator to establish his own system to comply with a national system for nuclear material accounting and control and to facilitate application of IAEA safeguards. The scope of this document is limited to descriptions of the following SSAC elements: (1) Nuclear Material Measurements; (2) Measurement Quality; (3) Records and Reports; (4) Physical Inventory Taking; (5) Material Balance Closing

  11. Research on decommissioning of nuclear facilities (Joint research)

    International Nuclear Information System (INIS)

    Shibahara, Yuji; Morishita, Yoshitsugu; Ishigami, Tsutomu; Yanagihara, Satoshi; Arita, Yuji

    2011-07-01

    To implement a decommissioning project reasonably, it is necessary and important to beforehand evaluate project management data as well as to select an optimum dismantling scenario among various scenarios postulated. Little study on the subject of selecting an optimum scenario has been carried out, and it is one of the most important subjects in terms of decision making. In FY 2009, Japan Atomic Energy Agency and University of Fukui launched the joint research of a decision making method which is important to determine a decommissioning plan. The purpose of the research is to construct a methodology for selecting an optimum dismantling scenario among various scenarios postulated based on calculated results of project management data for FUGEN. Project management data for several dismantling scenarios postulated at FUGEN were evaluated based on actual dismantling work for feed water heater at FUGEN, and an optimum scenario was discussed using the SMART, one of Multi-Criteria Decision Analysis Method. This report describes the results of the joint research in FY 2009. (author)

  12. ARM Climate Research Facility Monthly Instrument Report August 2010

    Energy Technology Data Exchange (ETDEWEB)

    Voyles, JW

    2010-09-28

    The purpose of this report is to provide a concise but comprehensive overview of Atmospheric Radiation Measurement Climate Research Facility instrumentation status. The report is divided into the following five sections: (1) new instrumentation in the process of being acquired and deployed, (2) field campaigns, (3) existing instrumentation and progress on improvements or upgrades, (4) proposed future instrumentation, and (5) Small Business Innovation Research instrument development.

  13. ARM Climate Research Facility Instrumentation Status and Information October 2009

    Energy Technology Data Exchange (ETDEWEB)

    JW Voyles

    2009-10-01

    The purpose of this report is to provide a concise but comprehensive overview of Atmospheric Radiation Measurement Climate Research Facility instrumentation status. The report is divided into the following five sections: (1) new instrumentation in the process of being acquired and deployed, (2) field campaigns, (3) existing instrumentation and progress on improvements or upgrades, (4) proposed future instrumentation, and (5) Small Business Innovation Research instrument development.

  14. ARM Climate Research Facility Instrumentation Status and Information April 2010

    Energy Technology Data Exchange (ETDEWEB)

    Voyles, JW

    2010-05-15

    The purpose of this report is to provide a concise but comprehensive overview of Atmospheric Radiation Measurement Climate Research Facility instrumentation status. The report is divided into the following five sections: (1) new instrumentation in the process of being acquired and deployed, (2) field campaigns, (3) existing instrumentation and progress on improvements or upgrades, (4) proposed future instrumentation, and (5) Small Business Innovation Research instrument development.

  15. ARM Climate Research Facility Instrumentation Status and Information January 2010

    Energy Technology Data Exchange (ETDEWEB)

    JW Voyles

    2010-02-28

    The purpose of this report is to provide a concise but comprehensive overview of Atmospheric Radiation Measurement Climate Research Facility instrumentation status. The report is divided into the following five sections: (1) new instrumentation in the process of being acquired and deployed, (2) field campaigns, (3) existing instrumentation and progress on improvements or upgrades, (4) proposed future instrumentation, and (5) Small Business Innovation Research instrument development.

  16. ARM Climate Research Facility Monthly Instrument Report September 2010

    Energy Technology Data Exchange (ETDEWEB)

    Voyles, JW

    2010-10-18

    The purpose of this report is to provide a concise but comprehensive overview of Atmospheric Radiation Measurement Climate Research Facility instrumentation status. The report is divided into the following five sections: (1) new instrumentation in the process of being acquired and deployed, (2) field campaigns, (3) existing instrumentation and progress on improvements or upgrades, (4) proposed future instrumentation, and (5) Small Business Innovation Research instrument development.

  17. ARM Climate Research Facility Instrumentation Status and Information March 2010

    Energy Technology Data Exchange (ETDEWEB)

    Voyles, JW

    2010-04-19

    The purpose of this report is to provide a concise but comprehensive overview of Atmospheric Radiation Measurement Climate Research Facility instrumentation status. The report is divided into the following five sections: (1) new instrumentation in the process of being acquired and deployed, (2) field campaigns, (3) existing instrumentation and progress on improvements or upgrades, (4) proposed future instrumentation, and (5) Small Business Innovation Research instrument development.

  18. ARM Climate Research Facility Monthly Instrument Report May 2010

    Energy Technology Data Exchange (ETDEWEB)

    Voyles, JW

    2010-06-21

    The purpose of this report is to provide a concise but comprehensive overview of Atmospheric Radiation Measurement Climate Research Facility instrumentation status. The report is divided into the following five sections: (1) new instrumentation in the process of being acquired and deployed, (2) field campaigns, (3) existing instrumentation and progress on improvements or upgrades, (4) proposed future instrumentation, and (5) Small Business Innovation Research instrument development.

  19. ARM Climate Research Facility Instrumentation Status and Information February 2010

    Energy Technology Data Exchange (ETDEWEB)

    Voyles, JW

    2010-03-25

    The purpose of this report is to provide a concise but comprehensive overview of Atmospheric Radiation Measurement Climate Research Facility instrumentation status. The report is divided into the following five sections: (1) new instrumentation in the process of being acquired and deployed, (2) field campaigns, (3) existing instrumentation and progress on improvements or upgrades, (4) proposed future instrumentation, and (5) Small Business Innovation Research instrument development.

  20. ARM Climate Research Facility Monthly Instrument Report June 2010

    Energy Technology Data Exchange (ETDEWEB)

    Voyles, JW

    2010-07-13

    The purpose of this report is to provide a concise but comprehensive overview of Atmospheric Radiation Measurement Climate Research Facility instrumentation status. The report is divided into the following five sections: (1) new instrumentation in the process of being acquired and deployed, (2) field campaigns, (3) existing instrumentation and progress on improvements or upgrades, (4) proposed future instrumentation, and (5) Small Business Innovation Research instrument development.

  1. ARM Climate Research Facility Instrumentation Status and Information December 2009

    Energy Technology Data Exchange (ETDEWEB)

    JW Voyles

    2010-12-30

    The purpose of this report is to provide a concise but comprehensive overview of Atmospheric Radiation Measurement Climate Research Facility instrumentation status. The report is divided into the following five sections: (1) new instrumentation in the process of being acquired and deployed, (2) field campaigns, (3) existing instrumentation and progress on improvements or upgrades, (4) proposed future instrumentation, and (5) Small Business Innovation Research instrument development.

  2. ARM Climate Research Facility Monthly Instrument Report July 2010

    Energy Technology Data Exchange (ETDEWEB)

    Voyles, JW

    2010-08-18

    The purpose of this report is to provide a concise but comprehensive overview of Atmospheric Radiation Measurement Climate Research Facility instrumentation status. The report is divided into the following five sections: (1) new instrumentation in the process of being acquired and deployed, (2) field campaigns, (3) existing instrumentation and progress on improvements or upgrades, (4) proposed future instrumentation, and (5) Small Business Innovation Research instrument development.

  3. Genephony: a knowledge management tool for genome-wide research

    Directory of Open Access Journals (Sweden)

    Riva Alberto

    2009-09-01

    Full Text Available Abstract Background One of the consequences of the rapid and widespread adoption of high-throughput experimental technologies is an exponential increase of the amount of data produced by genome-wide experiments. Researchers increasingly need to handle very large volumes of heterogeneous data, including both the data generated by their own experiments and the data retrieved from publicly available repositories of genomic knowledge. Integration, exploration, manipulation and interpretation of data and information therefore need to become as automated as possible, since their scale and breadth are, in general, beyond the limits of what individual researchers and the basic data management tools in normal use can handle. This paper describes Genephony, a tool we are developing to address these challenges. Results We describe how Genephony can be used to manage large datesets of genomic information, integrating them with existing knowledge repositories. We illustrate its functionalities with an example of a complex annotation task, in which a set of SNPs coming from a genotyping experiment is annotated with genes known to be associated to a phenotype of interest. We show how, thanks to the modular architecture of Genephony and its user-friendly interface, this task can be performed in a few simple steps. Conclusion Genephony is an online tool for the manipulation of large datasets of genomic information. It can be used as a browser for genomic data, as a high-throughput annotation tool, and as a knowledge discovery tool. It is designed to be easy to use, flexible and extensible. Its knowledge management engine provides fine-grained control over individual data elements, as well as efficient operations on large datasets.

  4. Procedures for economic distribution of radionuclides in research facilities

    International Nuclear Information System (INIS)

    Perry, N.A.

    1979-01-01

    A radionuclide accountability system for use in a research facility is described. It can be operated manually or adapted for computer use. All radionuclides are ordered, received, distributed and paid for by the Radiological Control Office who keep complete records of date of order, receipt, calibration use, transfer and/or disposal. Wipe leak tests, specific activity and lot number are also recorded. The procedure provides centralized total accountability records, including financial records, of all radionuclide orders, and the economic advantages of combined purchasing. The use of this system in two medical facilities has resulted in considerable financial savings in the first year of operation. (author)

  5. Introducing COSS: A new and unique oil spill research facility

    International Nuclear Information System (INIS)

    Kitchen, R. B.; Bonner, J. S.; Autenrieth, R. L.; Donnelly, K. C.; Ernest, A. N. S.

    1997-01-01

    A new oil spill research facility in Corpus Christi, Texas began operation in April 1997 to address the appropriate use, application and effectiveness of chemical, physical and biological oil spill response agents. The Coastal Oil Spill Simulation (COSS) facility consists of nine meso scale wave tanks and will offer to science and industry a unique opportunity to spill oil in a controlled environment and to study fate, transport and remediation of oil releases in simulated coastal, intertidal, lagunal, channel and porous media. 1 ref

  6. Parallel computing in genomic research: advances and applications.

    Science.gov (United States)

    Ocaña, Kary; de Oliveira, Daniel

    2015-01-01

    Today's genomic experiments have to process the so-called "biological big data" that is now reaching the size of Terabytes and Petabytes. To process this huge amount of data, scientists may require weeks or months if they use their own workstations. Parallelism techniques and high-performance computing (HPC) environments can be applied for reducing the total processing time and to ease the management, treatment, and analyses of this data. However, running bioinformatics experiments in HPC environments such as clouds, grids, clusters, and graphics processing unit requires the expertise from scientists to integrate computational, biological, and mathematical techniques and technologies. Several solutions have already been proposed to allow scientists for processing their genomic experiments using HPC capabilities and parallelism techniques. This article brings a systematic review of literature that surveys the most recently published research involving genomics and parallel computing. Our objective is to gather the main characteristics, benefits, and challenges that can be considered by scientists when running their genomic experiments to benefit from parallelism techniques and HPC capabilities.

  7. The SARAF Project - Soreq Applied Research Accelerator Facility

    International Nuclear Information System (INIS)

    Nagler, A.; Mardor, I.; Berkovits, D.; Piel, C.

    2004-01-01

    The relevance of particle accelerators to society, in the use of their primary and secondary beams for the analysis of physical, chemical and biological samples and for modification of properties of materials, is well recognized and documented. Nevertheless, apart of the construction of small accelerators for nuclear research in the 1960's and 70's, Israel has so far neglected this important and growing field. Furthermore, there is an urgent need in Israel for a state of the art research facility to attract and introduce students to current advanced physics techniques and technologies and to train the next generation of experimental scientists in various branches and disciplines. Therefore, Soreq NRC recently initiated the establishment of a new accelerator facility, named SARAF Soreq Applied Research Accelerator Facility. SARAF will be a continuous wave (CW), proton and deuteron RF superconducting linear accelerator with variable energy (5 - 40 MeV) and current (0.04 -2 mA). SARAF is designed to enable hands-on maintenance, which means that its beam loss will be below 10 -5 for the entire accelerator. These specifications will place SARAF in line with the next generation of accelerators world wide. Soreq expects that this fact will attract the Israeli and international research communities to use this facility extensively. Soreq NRC intends to use SARAF for basic, medical and biological research, and non-destructive testing (NDT). Another major activity will be the research and development of radio-isotopes production techniques. Given the availability of high current (up to 2 mA) protons and deuterons, a major activity will be research and development of high power density (up to 80 kW on a few cm 2 ) irradiation targets

  8. Research Facility for Mechanical Press Closed Gap Adjuster

    Directory of Open Access Journals (Sweden)

    A. A. Ancifirov

    2016-01-01

    Full Text Available The article describes an example of the research facility for closed gap adjustment mechanism based on the KD2128 closed-die forging press. Its rated force with a servo drive used is 630kN. The servo drive consists of a motor with nominal power of 1.57kW and a frequency converter with power of 7.5kW, which has functions of the programmable logic controller.The article notes that such a facility is expedient and useful for practical classes on forging-andstamping machines at the BMSTU Department of «Technology processing by pressure» to demonstrate the capabilities of existing technological facility, learn a design of forging-andstamping machine units, solve the problems of automatic control, monitoring, and diagnostics in blank manufacturing.The article presents a detailed facility diagram of the closed gap adjustment mechanism and its photograph, describes the mechanism and its basic parameters, gives characteristics of the synchronous motor to drive the mechanism, reviews practical works, which the research facility may provide.Based on the four experiments the article estimates an efficiency of the research facilityuse under consideration, especially when modeling a servo motor shaft under the maximum load. The relevant diagrams confirm experimental results, namely: control current, angle of motor shaft and its speed versus time. Thus, upon the diagram analysis it can be noted that the research facility design allows providing kinematics and dynamics of the press closed gap adjuster.This article describes how to determine the closed gap adjusting accuracy of the press. Eight experiments have been conducted to evaluate a working out control signal to the linear movement of the press punch when using the research facility. It is noted that the linear positioning accuracy of the press punch reaches the hundredth parts of a millimeter of the adjustment value that is sufficient to achieve the required precision when performing operations such as

  9. BALU: Largest autoclave research facility in the world

    Directory of Open Access Journals (Sweden)

    Hakan Ucan

    2016-03-01

    Full Text Available Among the large-scale facilities operated at the Center for Lightweight-Production-Technology of the German Aerospace Center in Stade BALU is the world's largest research autoclave. With a loading length of 20m and a loading diameter of 5.8 m the main objective of the facility is the optimization of the curing process operated by components made of carbon fiber on an industrial scale. For this reason, a novel dynamic autoclaving control has been developed that is characterized by peripheral devices to expend the performance of the facility for differential applications, by sensing systems to detect the component state throughout the curing process and by a feedback system, which is capable to intervene into the running autoclave process.

  10. NEW IRRADIATION RESEARCH FACILITIES AT THE ARMY NATICK LABORATORIES

    Energy Technology Data Exchange (ETDEWEB)

    Cooper, R. D.; Brynjolfsson, A.

    1963-03-15

    New facilities built by the U. S. Army for research on the preservation of food by ionizing radiation consist of a food processing and packaging facility and a radiation sources laboratory with two powerful low-energy radiation sources. One is a 1.3 million-curie Co/sup 60/ source consisting of 98 tubes each containing four doubly encapsulated Co/sup 60/ slugs. The second source is an electron linear accelerator with energy variable between 2 and 32 Mev. Research with the Co/sup 60/ source is concentrated on investigation of macroscopic and microscopic dose distribution in different materials irradiated with Co/sup 60/ gamma rays. Research with the linear accelerator is concentrated on dosimetry and photonuclear reactions. (A.G.W.)

  11. The reactor and cold neutron research facility at NIST

    Energy Technology Data Exchange (ETDEWEB)

    Prask, H J; Rowe, J M [Reactor Radiation Division, National Institute of Standards and Technology, Gaithersburg, MD (United States)

    1992-07-01

    The NIST Reactor (NBSR) is a 20 MW research reactor located at the Gaithersburg, MD site, and has been in operation since 1969. It services 26 thermal neutron facilities which are used for materials science, chemical analysis, nondestructive evaluation, neutron standards work, and irradiations. In 1987 the Department of Commerce and NIST began development of the CNRF - a $30M National Facility for cold neutron research -which will provide fifteen new experimental stations with capabilities currently unavailable in this country. As of May 1992, four of the planned seven guides and a cold port were installed, eight cold neutron experimental stations were operational, and the Call for Proposals for the second cycle of formally-reviewed guest-researcher experiments had been sent out. Some details of the performance of instrumentation are described, along with the proposed design of the new hydrogen cold source which will replace the present D{sub 2}O/H{sub 2}O ice cold source. (author)

  12. The reactor and cold neutron research facility at NIST

    International Nuclear Information System (INIS)

    Prask, H.J.; Rowe, J.M.

    1992-01-01

    The NIST Reactor (NBSR) is a 20 MW research reactor located at the Gaithersburg, MD site, and has been in operation since 1969. It services 26 thermal neutron facilities which are used for materials science, chemical analysis, nondestructive evaluation, neutron standards work, and irradiations. In 1987 the Department of Commerce and NIST began development of the CNRF - a $30M National Facility for cold neutron research -which will provide fifteen new experimental stations with capabilities currently unavailable in this country. As of May 1992, four of the planned seven guides and a cold port were installed, eight cold neutron experimental stations were operational, and the Call for Proposals for the second cycle of formally-reviewed guest-researcher experiments had been sent out. Some details of the performance of instrumentation are described, along with the proposed design of the new hydrogen cold source which will replace the present D 2 O/H 2 O ice cold source. (author)

  13. Promoting synergistic research and education in genomics and bioinformatics.

    Science.gov (United States)

    Yang, Jack Y; Yang, Mary Qu; Zhu, Mengxia Michelle; Arabnia, Hamid R; Deng, Youping

    2008-01-01

    Bioinformatics and Genomics are closely related disciplines that hold great promises for the advancement of research and development in complex biomedical systems, as well as public health, drug design, comparative genomics, personalized medicine and so on. Research and development in these two important areas are impacting the science and technology.High throughput sequencing and molecular imaging technologies marked the beginning of a new era for modern translational medicine and personalized healthcare. The impact of having the human sequence and personalized digital images in hand has also created tremendous demands of developing powerful supercomputing, statistical learning and artificial intelligence approaches to handle the massive bioinformatics and personalized healthcare data, which will obviously have a profound effect on how biomedical research will be conducted toward the improvement of human health and prolonging of human life in the future. The International Society of Intelligent Biological Medicine (http://www.isibm.org) and its official journals, the International Journal of Functional Informatics and Personalized Medicine (http://www.inderscience.com/ijfipm) and the International Journal of Computational Biology and Drug Design (http://www.inderscience.com/ijcbdd) in collaboration with International Conference on Bioinformatics and Computational Biology (Biocomp), touch tomorrow's bioinformatics and personalized medicine throughout today's efforts in promoting the research, education and awareness of the upcoming integrated inter/multidisciplinary field. The 2007 international conference on Bioinformatics and Computational Biology (BIOCOMP07) was held in Las Vegas, the United States of American on June 25-28, 2007. The conference attracted over 400 papers, covering broad research areas in the genomics, biomedicine and bioinformatics. The Biocomp 2007 provides a common platform for the cross fertilization of ideas, and to help shape knowledge and

  14. International Space Station Research and Facilities for Life Sciences

    Science.gov (United States)

    Robinson, Julie A.; Ruttley, Tara M.

    2009-01-01

    Assembly of the International Space Station is nearing completion in fall of 2010. Although assembly has been the primary objective of its first 11 years of operation, early science returns from the ISS have been growing at a steady pace. Laboratory facilities outfitting has increased dramatically 2008-2009 with the European Space Agency s Columbus and Japanese Aerospace Exploration Agency s Kibo scientific laboratories joining NASA s Destiny laboratory in orbit. In May 2009, the ISS Program met a major milestone with an increase in crew size from 3 to 6 crewmembers, thus greatly increasing the time available to perform on-orbit research. NASA will launch its remaining research facilities to occupy all 3 laboratories in fall 2009 and winter 2010. To date, early utilization of the US Operating Segment of the ISS has fielded nearly 200 experiments for hundreds of ground-based investigators supporting international and US partner research. With a specific focus on life sciences research, this paper will summarize the science accomplishments from early research aboard the ISS- both applied human research for exploration, and research on the effects of microgravity on life. We will also look ahead to the full capabilities for life sciences research when assembly of ISS is complete in 2010.

  15. Criticality safety research on nuclear fuel cycle facility

    Energy Technology Data Exchange (ETDEWEB)

    Miyoshi, Yoshinori [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment

    2004-07-01

    This paper present d s current status and future program of the criticality safety research on nuclear fuel cycle made by Japan Atomic Energy Research Institute. Experimental research on solution fuel treated in reprocessing plant has been performed using two critical facilities, STACY and TRACY. Fundamental data of static and transient characteristics are accumulated for validation of criticality safety codes. Subcritical measurements are also made for developing a monitoring system for criticality safety. Criticality safety codes system for solution and power system, and evaluation method related to burnup credit are developed. (author)

  16. 77 FR 2735 - National Human Genome Research Institute; Notice of Meetings

    Science.gov (United States)

    2012-01-19

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Human Genome... personal privacy. Name of Committee: National Advisory Council for Human Genome Research. Date: February 13... Extramural Research National Human Genome Research Institute, 5635 Fishers Lane, Suite 4076, MSC 9305...

  17. 75 FR 2147 - National Human Genome Research Institute; Notice of Meetings

    Science.gov (United States)

    2010-01-14

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Human Genome... Council for Human Genome Research. The meetings will be open to the public as indicated below, with... Extramural Research, National Human Genome Research Institute, 5635 Fishers Lane, Suite 4076, MSC 9305...

  18. 75 FR 51828 - National Human Genome Research Institute; Notice of Meetings

    Science.gov (United States)

    2010-08-23

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Human Genome... personal privacy. Name of Committee: National Advisory Council for Human Genome Research. Date: February 7... Research, National Human Genome Research Institute, 5635 Fishers Lane, Suite 4076, MSC 9305, Bethesda, MD...

  19. Invited review: Genetic and genomic mouse models for livestock research

    Directory of Open Access Journals (Sweden)

    D. Arends

    2018-02-01

    Full Text Available Knowledge about the function and functioning of single or multiple interacting genes is of the utmost significance for understanding the organism as a whole and for accurate livestock improvement through genomic selection. This includes, but is not limited to, understanding the ontogenetic and environmentally driven regulation of gene action contributing to simple and complex traits. Genetically modified mice, in which the functions of single genes are annotated; mice with reduced genetic complexity; and simplified structured populations are tools to gain fundamental knowledge of inheritance patterns and whole system genetics and genomics. In this review, we briefly describe existing mouse resources and discuss their value for fundamental and applied research in livestock.

  20. Rabbit models for biomedical research revisited via genome editing approaches

    Science.gov (United States)

    HONDA, Arata; OGURA, Atsuo

    2017-01-01

    Although the laboratory rabbit has long contributed to many paradigmatic studies in biology and medicine, it is often considered to be a “classical animal model” because in the last 30 years, the laboratory mouse has been more often used, thanks to the availability of embryonic stem cells that have allowed the generation of gene knockout (KO) animals. However, recent genome-editing strategies have changed this unrivaled condition; so far, more than 10 mammalian species have been added to the list of KO animals. Among them, the rabbit has distinct advantages for application of genome-editing systems, such as easy application of superovulation, consistency with fertile natural mating, well-optimized embryo manipulation techniques, and the short gestation period. The rabbit has now returned to the stage of advanced biomedical research. PMID:28579598

  1. Neutron beam facilities at the replacement research reactor

    International Nuclear Information System (INIS)

    Kennedy, S.

    1999-01-01

    Full text: On September 3rd 1997 the Australian Federal Government announced their decision to replace the HIFAR research reactor by 2005. The proposed reactor will be a multipurpose reactor with improved capabilities for neutron beam research and for the production of radioisotopes for pharmaceutical, scientific and industrial use. The neutron beam facilities are intended to cater for Australian scientific needs well into the 21st century. In the first stage of planning the neutron Beam Facilities at the replacement reactor, a Consultative Group was formed (BFCG) to determine the scientific capabilities of the new facility. Members of the group were drawn from academia, industry and government research laboratories. The BFCG submitted their report in April 1998, outlining the scientific priorities to be addressed. Cold and hot neutron sources are to be included, and cold and thermal neutron guides will be used to position most of the instruments in a neutron guide hall outside the reactor confinement building. In 2005 it is planned to have eight instruments installed with a further three to be developed by 2010, and seven spare instrument positions for development of new instruments over the life of the reactor. A beam facilities technical group (BFTG) was then formed to prepare the engineering specifications for the tendering process. The group consisted of some members of the BFCG, several scientists and engineers from ANSTO, and scientists from leading neutron scattering centres in Europe, USA and Japan. The BFTG looked in detail at the key components of the facility such as the thermal, cold and hot neutron sources, neutron collimators, neutron beam guides and overall requirements for the neutron guide hall. The report of the BFTG, completed in August 1998, was incorporated into the draft specifications for the reactor project, which were distributed to potential reactor vendors. An assessment of the first stage of reactor vendor submissions was completed in

  2. Small-scale hot facility for reprocessing and alpha research

    International Nuclear Information System (INIS)

    Abdel-Rassoul, A.A.

    1976-01-01

    The experimental hot facility at Inchas is planned for research activities related to the decontamination of radioactive wastes, analytical chemistry of alpha emitters and chemical treatment of spent UO 2 -Mg fuel samples. The design concept permits safe handling of source materials with radioactivity levels up to 10000Ci. The laboratory includes a reception area, process hall, a number of research laboratories and other facilities for chemical and physical analysis, nuclear measurements and health physics control. The radioactive waste management plant allows for control and decontamination of intermediate- and low-level laboratory effluents. Fixation of radioactive residues will be carried out in the sludge immobilization plant. High-level fission-product waste liquors are subject to preconcentration and transformation to a glassy matrix before ultimate storage. (author)

  3. Recent activities at the ORNL multicharged ion research facility (MIRF)

    International Nuclear Information System (INIS)

    Meyer, F.W.; Bannister, M.E.; Hale, J.W.; Havener, C.C.; Krause, H.F.; Vane, C.R.; Deng, S.; Draganic, I.N.; Harris, P.R.

    2012-01-01

    Recent activities at the ORNL Multicharged Ion Research Facility (MIRF) are summarized. A brief summary of the MIRF high voltage (HV) platform and floating beam line upgrade is provided. An expansion of our research program to the use of molecular ion beams in heavy-particle and electron collisions, as well as in ion surface interactions is described, and a brief description is provided of the most recently added Ion Cooling and Characterization End-station (ICCE) trap. With the expansion to include molecular ion beams, the acronym MIRF for the facility, however, remains unchanged: 'M' can now refer to either 'Multicharged' or 'Molecular'. The paper is followed by the slides of the presentation. (authors)

  4. A test matrix sequencer for research test facility automation

    Science.gov (United States)

    Mccartney, Timothy P.; Emery, Edward F.

    1990-01-01

    The hardware and software configuration of a Test Matrix Sequencer, a general purpose test matrix profiler that was developed for research test facility automation at the NASA Lewis Research Center, is described. The system provides set points to controllers and contact closures to data systems during the course of a test. The Test Matrix Sequencer consists of a microprocessor controlled system which is operated from a personal computer. The software program, which is the main element of the overall system is interactive and menu driven with pop-up windows and help screens. Analog and digital input/output channels can be controlled from a personal computer using the software program. The Test Matrix Sequencer provides more efficient use of aeronautics test facilities by automating repetitive tasks that were once done manually.

  5. ARM Climate Research Facility Quarterly Value-Added Product Report

    Energy Technology Data Exchange (ETDEWEB)

    Sivaraman, Chitra

    2014-01-14

    The purpose of this report is to provide a concise status update for value-added products (VAP) implemented by the Atmospheric Radiation Measurement Climate Research Facility. The report is divided into the following sections: (1) new VAPs for which development has begun, (2) progress on existing VAPs, (3) future VAPs that have been recently approved, (4) other work that leads to a VAP, and (5) top requested VAPs from the archive.

  6. Basic Design of the Cold Neutron Research Facility in HANARO

    International Nuclear Information System (INIS)

    Kim, Hark Rho; Lee, K. H.; Kim, Y. K.

    2005-09-01

    The HANARO Cold Neutron Research Facility (CNRF) Project has been embarked in July 2003. The CNRF project has selected as one of the radiation technology development project by National Science and Technology Committee in June 2002. In this report, the output of the second project year is summarized as a basic design of cold neutron source and related systems, neutron guide, and neutron scattering instruments

  7. Basic Design of the Cold Neutron Research Facility in HANARO

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Hark Rho; Lee, K. H.; Kim, Y. K. (and others)

    2005-09-15

    The HANARO Cold Neutron Research Facility (CNRF) Project has been embarked in July 2003. The CNRF project has selected as one of the radiation technology development project by National Science and Technology Committee in June 2002. In this report, the output of the second project year is summarized as a basic design of cold neutron source and related systems, neutron guide, and neutron scattering instruments.

  8. ARM Climate Research Facility Quarterly Ingest Status Report

    Energy Technology Data Exchange (ETDEWEB)

    Koontz, A. [DOE ARM Climate Research Facility, Washington, DC (United States); Sivaraman, C. [DOE ARM Climate Research Facility, Washington, DC (United States)

    2016-10-01

    The purpose of this report is to provide a concise status update for ingests maintained by the Atmospheric Radiation Measurement (ARM) Climate Research Facility. The report is divided into the following sections: (1) new ingests for which development has begun, (2) progress on existing ingests, (3) future ingests that have been recently approved, (4) other work that leads to an ingest, and (5) top requested ingests from the ARM Data Archive. New information is highlighted in blue text.

  9. ARM Climate Research Facility Quarterly Ingest Status Report

    Energy Technology Data Exchange (ETDEWEB)

    Koontz, A. [ARM Climate Reesearch Facility, Washington, DC (United States); Sivaraman, C. [ARM Climate Reesearch Facility, Washington, DC (United States)

    2016-07-01

    The purpose of this report is to provide a concise status update for ingests maintained by the Atmospheric Radiation Measurement (ARM) Climate Research Facility. The report is divided into the following sections: (1) new ingests for which development has begun, (2) progress on existing ingests, (3) future ingests that have been recently approved, (4) other work that leads to an ingest, and (5) top requested ingests from the ARM Data Archive. New information is highlighted in blue text.

  10. Development of an Extreme Environment Materials Research Facility at Princeton

    International Nuclear Information System (INIS)

    Cohen, A.B.; Gentile, C.A.; Tully, C.G.; Austin, R.; Calaprice, F.; McDonald, K.; Ascione, G.; Baker, G.; Davidson, R.; Dudek, L.; Grisham, L.; Kugel, H.; Pagdon, K.; Stevenson, T.; Woolley, R.; Zwicker, A.

    2010-01-01

    The need for a fundamental understanding of material response to a neutron and/or high heat flux environment can yield development of improved materials and operations with existing materials. Such understanding has numerous applications in fields such as nuclear power (for the current fleet and future fission and fusion reactors), aerospace, and other research fields (e.g., high-intensity proton accelerator facilities for high energy physics research). A proposal has been advanced to develop a facility for testing various materials under extreme heat and neutron exposure conditions at Princeton. The Extreme Environment Materials Research Facility comprises an environmentally controlled chamber (48 m 3 ) capable of high vacuum conditions, with extreme flux beams and probe beams accessing a central, large volume target. The facility will have the capability to expose large surface areas (1 m 2 ) to 14 MeV neutrons at a fluence in excess of 10 13 n/s. Depending on the operating mode. Additionally beam line power on the order of 15-75 MW/m 2 for durations of 1-15 seconds are planned. The multi-second duration of exposure can be repeated every 2-10 minutes for periods of 10-12 hours. The facility will be housed in the test cell that held the Tokamak Fusion Test Reactor (TFTR), which has the desired radiation and safety controls as well as the necessary loading and assembly infrastructure. The facility will allow testing of various materials to their physical limit of thermal endurance and allow for exploring the interplay between radiation-induced embrittlement, swelling and deformation of materials, and the fatigue and fracturing that occur in response to thermal shocks. The combination of high neutron energies and intense fluences will enable accelerated time scale studies. The results will make contributions for refining predictive failure modes (modeling) in extreme environments, as well as providing a technical platform for the development of new alloys, new

  11. "Atmospheric Radiation Measurement (ARM) Research Facility at Oliktok Point Alaska"

    Science.gov (United States)

    Helsel, F.; Ivey, M.; Hardesty, J.; Roesler, E. L.; Dexheimer, D.

    2017-12-01

    Scientific Infrastructure To Support Atmospheric Science, Aerosol Science and UAS's for The Department Of Energy's Atmospheric Radiation Measurement Programs At The Mobile Facility 3 Located At Oliktok Point, Alaska.The Atmospheric Radiation Measurement (ARM) Program's Mobile Facility 3 (AMF3) located at Oliktok Point, Alaska is a U.S. Department of Energy (DOE) site designed to collect data and help determine the impact that clouds and aerosols have on solar radiation. AMF3 provides a scientific infrastructure to support instruments and collect arctic data for the international arctic research community. The infrastructure at AMF3/Oliktok is designed to be mobile and it may be relocated in the future to support other ARM science missions. AMF3's present base line instruments include: scanning precipitation Radars, cloud Radar, Raman Lidar, Eddy correlation flux systems, Ceilometer, Balloon sounding system, Atmospheric Emitted Radiance Interferometer (AERI), Micro-pulse Lidar (MPL) Along with all the standard metrological measurements. In addition AMF3 provides aerosol measurements with a Mobile Aerosol Observing System (MAOS). Ground support for Unmanned Aerial Systems (UAS) and tethered balloon flights. Data from these instruments and systems are placed in the ARM data archives and are available to the international research community. This poster will discuss what instruments and systems are at the ARM Research Facility at Oliktok Point Alaska.

  12. Atmospheric Radiation Measurement Climate Research Facility (ACRF) Annual Report 2007

    Energy Technology Data Exchange (ETDEWEB)

    LR Roeder

    2007-12-01

    This annual report describes the purpose and structure of the program, and presents key accomplishments in 2007. Notable achievements include: • Successful review of the ACRF as a user facility by the DOE Biological and Environmental Research Advisory Committee. The subcommittee reinforced the importance of the scientific impacts of this facility, and its value for the international research community. • Leadership of the Cloud Land Surface Interaction Campaign. This multi-agency, interdisciplinary field campaign involved enhanced surface instrumentation at the ACRF Southern Great Plains site and, in concert with the Cumulus Humilis Aerosol Processing Study sponsored by the DOE Atmospheric Science Program, coordination of nine aircraft through the ARM Aerial Vehicles Program. • Successful deployment of the ARM Mobile Facility in Germany, including hosting nearly a dozen guest instruments and drawing almost 5000 visitors to the site. • Key advancements in the representation of radiative transfer in weather forecast models from the European Centre for Medium-Range Weather Forecasts. • Development of several new enhanced data sets, ranging from best estimate surface radiation measurements from multiple sensors at all ACRF sites to the extension of time-height cloud occurrence profiles to Niamey, Niger, Africa. • Publication of three research papers in a single issue (February 2007) of the Bulletin of the American Meteorological Society.

  13. GDR (Genome Database for Rosaceae: integrated web resources for Rosaceae genomics and genetics research

    Directory of Open Access Journals (Sweden)

    Ficklin Stephen

    2004-09-01

    Full Text Available Abstract Background Peach is being developed as a model organism for Rosaceae, an economically important family that includes fruits and ornamental plants such as apple, pear, strawberry, cherry, almond and rose. The genomics and genetics data of peach can play a significant role in the gene discovery and the genetic understanding of related species. The effective utilization of these peach resources, however, requires the development of an integrated and centralized database with associated analysis tools. Description The Genome Database for Rosaceae (GDR is a curated and integrated web-based relational database. GDR contains comprehensive data of the genetically anchored peach physical map, an annotated peach EST database, Rosaceae maps and markers and all publicly available Rosaceae sequences. Annotations of ESTs include contig assembly, putative function, simple sequence repeats, and anchored position to the peach physical map where applicable. Our integrated map viewer provides graphical interface to the genetic, transcriptome and physical mapping information. ESTs, BACs and markers can be queried by various categories and the search result sites are linked to the integrated map viewer or to the WebFPC physical map sites. In addition to browsing and querying the database, users can compare their sequences with the annotated GDR sequences via a dedicated sequence similarity server running either the BLAST or FASTA algorithm. To demonstrate the utility of the integrated and fully annotated database and analysis tools, we describe a case study where we anchored Rosaceae sequences to the peach physical and genetic map by sequence similarity. Conclusions The GDR has been initiated to meet the major deficiency in Rosaceae genomics and genetics research, namely a centralized web database and bioinformatics tools for data storage, analysis and exchange. GDR can be accessed at http://www.genome.clemson.edu/gdr/.

  14. GDR (Genome Database for Rosaceae): integrated web resources for Rosaceae genomics and genetics research.

    Science.gov (United States)

    Jung, Sook; Jesudurai, Christopher; Staton, Margaret; Du, Zhidian; Ficklin, Stephen; Cho, Ilhyung; Abbott, Albert; Tomkins, Jeffrey; Main, Dorrie

    2004-09-09

    Peach is being developed as a model organism for Rosaceae, an economically important family that includes fruits and ornamental plants such as apple, pear, strawberry, cherry, almond and rose. The genomics and genetics data of peach can play a significant role in the gene discovery and the genetic understanding of related species. The effective utilization of these peach resources, however, requires the development of an integrated and centralized database with associated analysis tools. The Genome Database for Rosaceae (GDR) is a curated and integrated web-based relational database. GDR contains comprehensive data of the genetically anchored peach physical map, an annotated peach EST database, Rosaceae maps and markers and all publicly available Rosaceae sequences. Annotations of ESTs include contig assembly, putative function, simple sequence repeats, and anchored position to the peach physical map where applicable. Our integrated map viewer provides graphical interface to the genetic, transcriptome and physical mapping information. ESTs, BACs and markers can be queried by various categories and the search result sites are linked to the integrated map viewer or to the WebFPC physical map sites. In addition to browsing and querying the database, users can compare their sequences with the annotated GDR sequences via a dedicated sequence similarity server running either the BLAST or FASTA algorithm. To demonstrate the utility of the integrated and fully annotated database and analysis tools, we describe a case study where we anchored Rosaceae sequences to the peach physical and genetic map by sequence similarity. The GDR has been initiated to meet the major deficiency in Rosaceae genomics and genetics research, namely a centralized web database and bioinformatics tools for data storage, analysis and exchange. GDR can be accessed at http://www.genome.clemson.edu/gdr/.

  15. Progress in developing the concept for the irradiation research facility

    International Nuclear Information System (INIS)

    Lee, A.G.; Bishop, W.E.; Gillespie, G.E.; Zeng, Y.

    1996-04-01

    At the 16th annual Canadian Nuclear Society conference, AECL presented the case for replacing the NRU reactor with an Irradiation Research Facility (IRF) to test CANDU fuels and materials and to perform advanced materials research using neutrons. AECL developed a cost estimate of $500 million for the reference IRF concept, and estimated that it would require 87 months to complete. AECL has initiated a pre-project program to develop the IRF concept and to minimize uncertainties related to feasibility and licensability, and to examine options for reducing the overall project cost before project implementation begins. (author) 10 refs., 2 figs

  16. The neutron radiography facility at Tehran Research Reactor (TRR)

    International Nuclear Information System (INIS)

    Ali Pazirandeh

    2009-01-01

    Full text: Non-destructive testing in many fields of industry including detection of explosives, at the airports, testing for micro-cracks on airplane wings and turbine blades cracks is badly needed. Thermal neutron beam is one of preferable method to detect the micro-cracks, reveals the internal structure of components and explosives. The purpose of this paper is to present the neutron radiography facility at Tehran Research Reactor (TRR), Science and Technology Research Institute, and in particular to emphasize the industrial applications in wood industry, automobile engine inspection, minerals composition identification, turbine blade cracks detection. (author)

  17. Status of CHESS facility and research programs: 2010

    Energy Technology Data Exchange (ETDEWEB)

    Fontes, Ernest, E-mail: ef11@cornell.edu [Cornell High Energy Synchrotron Source, Cornell University, Ithaca, NY 14853 (United States); Bilderback, Donald H.; Gruner, Sol M. [Cornell High Energy Synchrotron Source, Cornell University, Ithaca, NY 14853 (United States)

    2011-09-01

    CHESS is a hard X-ray synchrotron radiation national facility located at Cornell University and funded by the National Science Foundation. It is open to all scientists by peer-reviewed proposal and serves 500-1000 visitors each year. The CHESS scientific and technical staff develops forefront research tools and X-ray instrumentation and methods and supports 12 experimental stations delivering high intensity X-ray beams produced at 5.3 GeV and 250 mA. The facility consists of a mix of dedicated and flexible experimental stations that are easily configured for general X-ray diffraction (wide- and small-angle), spectroscopy, imaging applications, etc. Dedicated stations support high-pressure powder X-ray diffraction, pulsed-laser deposition for layer-by-layer growth of surfaces, and three dedicated stations for protein crystallography. Specialized resource groups at the laboratory include: an X-ray detector group; MacCHESS, an NIH-supported research resource for protein crystallography; the G-line division, which primarily organizes graduate students and Cornell faculty members around three X-ray stations; a high-pressure diamond-anvil cell support laboratory; and a monocapillary drawing facility for making microbeam X-ray optics. Research is also ongoing to upgrade CHESS to a first-ever 5 GeV, 100 mA Energy Recovery Linac (ERL) hard X-ray source. This source will provide ultra-high spectral-brightness and <100 fs short-pulse capability at levels well in advance of those possible with existing storage rings. It will produce diffraction-limited X-rays beams of up to 10 keV energy and be capable of providing 1 nm round beams. Prototyping for this facility is under way now to demonstrate critical DC photoelectron injector and superconducting linac technologies needed for the full-scale ERL.

  18. Status of CHESS facility and research programs: 2010

    International Nuclear Information System (INIS)

    Fontes, Ernest; Bilderback, Donald H.; Gruner, Sol M.

    2011-01-01

    CHESS is a hard X-ray synchrotron radiation national facility located at Cornell University and funded by the National Science Foundation. It is open to all scientists by peer-reviewed proposal and serves 500-1000 visitors each year. The CHESS scientific and technical staff develops forefront research tools and X-ray instrumentation and methods and supports 12 experimental stations delivering high intensity X-ray beams produced at 5.3 GeV and 250 mA. The facility consists of a mix of dedicated and flexible experimental stations that are easily configured for general X-ray diffraction (wide- and small-angle), spectroscopy, imaging applications, etc. Dedicated stations support high-pressure powder X-ray diffraction, pulsed-laser deposition for layer-by-layer growth of surfaces, and three dedicated stations for protein crystallography. Specialized resource groups at the laboratory include: an X-ray detector group; MacCHESS, an NIH-supported research resource for protein crystallography; the G-line division, which primarily organizes graduate students and Cornell faculty members around three X-ray stations; a high-pressure diamond-anvil cell support laboratory; and a monocapillary drawing facility for making microbeam X-ray optics. Research is also ongoing to upgrade CHESS to a first-ever 5 GeV, 100 mA Energy Recovery Linac (ERL) hard X-ray source. This source will provide ultra-high spectral-brightness and <100 fs short-pulse capability at levels well in advance of those possible with existing storage rings. It will produce diffraction-limited X-rays beams of up to 10 keV energy and be capable of providing 1 nm round beams. Prototyping for this facility is under way now to demonstrate critical DC photoelectron injector and superconducting linac technologies needed for the full-scale ERL.

  19. The neutron beam facility at the Australian replacement research reactor

    International Nuclear Information System (INIS)

    Hunter, B.; Kennedy, S.

    1999-01-01

    Full text: The Australian federal government gave ANSTO final approval to build a research reactor to replace HIFAR on August 25th 1999. The replacement reactor is to be a multipurpose reactor with a thermal neutron flux of 3 x 10 14 n.cm -2 .s -1 and having improved capabilities for neutron beam research and for the production of radioisotopes for pharmaceutical, scientific and industrial use. The replacement reactor will commence operation in 2005 and will cater for Australian scientific, industrial and medical needs well into the 21st century. The scientific capabilities of the neutron beams at the replacement reactor are being developed in consultation with representatives from academia, industry and government research laboratories to provide a facility for condensed matter research in physics, chemistry, materials science, life sciences, engineering and earth sciences. Cold, thermal and hot neutron sources are to be installed, and neutron guides will be used to position most of the neutron beam instruments in a neutron guide hall outside the reactor confinement building. Eight instruments are planned for 2005, with a further three to be developed by 2010. A conceptual layout for the neutron beam facility is presented including the location of the planned suite of neutron beam instruments. The reactor and all the associated infrastructure, with the exception of the neutron beam instruments, is to be built by an accredited reactor builder in a turnkey contract. Tenders have been called for December 1999, with selection of contractor planned by June 2000. The neutron beam instruments will be developed by ANSTO and other contracted organisations in consultation with the user community and interested overseas scientists. The facility will be based, as far as possible, around a neutron guide hall that is be served by three thermal and three cold neutron guides. Efficient transportation of thermal and cold neutrons to the guide hall requires the use of modern super

  20. Merging genomic and phenomic data for research and clinical impact.

    Science.gov (United States)

    Shublaq, Nour W; Coveney, Peter V

    2012-01-01

    Driven primarily by advances in genomics, pharmacogenomics and systems biology technologies, large amounts of genomic and phenomic data are today being collected on individuals worldwide. Integrative analysis, mining, and computer modeling of these data, facilitated by information technology, have led to the development of predictive, preventive, and personalized medicine. This transformative approach holds the potential inter alia to enable future general practitioners and physicians to prescribe the right drug to the right patient at the right dosage. For such patient-specific medicine to be adopted as standard clinical practice, publicly accumulated knowledge of genes, proteins, molecular functional annotations, and interactions need to be unified and with electronic health records including phenotypic information, most of which still reside as paper-based records in hospitals. We review the state-of-the-art in terms of electronic data capture and medical data standards. Some of these activities are drawn from research projects currently being performed within the European Virtual Physiological Human (VPH) initiative; all are being monitored by the VPH INBIOMEDvision Consortium. Various ethical, legal and societal issues linked with privacy will increasingly arise in the post-genomic era. This will require a closer interaction between the bioinformatics/systems biology and medical informatics/healthcare communities. Planning for how individuals will own their personal health records is urgently needed, as the cost of sequencing a whole human genome will soon be less than U.S. $100. We discuss some of the issues that will need to be addressed by society as a result of this revolution in healthcare.

  1. GRAbB : Selective Assembly of Genomic Regions, a New Niche for Genomic Research

    NARCIS (Netherlands)

    Brankovics, Balázs; Zhang, Hao; van Diepeningen, Anne D; van der Lee, Theo A J; Waalwijk, Cees; de Hoog, G Sybren

    GRAbB (Genomic Region Assembly by Baiting) is a new program that is dedicated to assemble specific genomic regions from NGS data. This approach is especially useful when dealing with multi copy regions, such as mitochondrial genome and the rDNA repeat region, parts of the genome that are often

  2. Psychometric model for safety culture assessment in nuclear research facilities

    International Nuclear Information System (INIS)

    Nascimento, C.S. do; Andrade, D.A.; Mesquita, R.N. de

    2017-01-01

    Highlights: • A psychometric model to evaluate ‘safety climate’ at nuclear research facilities. • The model presented evidences of good psychometric qualities. • The model was applied to nuclear research facilities in Brazil. • Some ‘safety culture’ weaknesses were detected in the assessed organization. • A potential tool to develop safety management programs in nuclear facilities. - Abstract: A safe and reliable operation of nuclear power plants depends not only on technical performance, but also on the people and on the organization. Organizational factors have been recognized as the main causal mechanisms of accidents by research organizations through USA, Europe and Japan. Deficiencies related with these factors reveal weaknesses in the organization’s safety culture. A significant number of instruments to assess the safety culture based on psychometric models that evaluate safety climate through questionnaires, and which are based on reliability and validity evidences, have been published in health and ‘safety at work’ areas. However, there are few safety culture assessment instruments with these characteristics (reliability and validity) available on nuclear literature. Therefore, this work proposes an instrument to evaluate, with valid and reliable measures, the safety climate of nuclear research facilities. The instrument was developed based on methodological principles applied to research modeling and its psychometric properties were evaluated by a reliability analysis and validation of content, face and construct. The instrument was applied to an important nuclear research organization in Brazil. This organization comprises 4 research reactors and many nuclear laboratories. The survey results made possible a demographic characterization and the identification of some possible safety culture weaknesses and pointing out potential areas to be improved in the assessed organization. Good evidence of reliability with Cronbach's alpha

  3. Psychometric model for safety culture assessment in nuclear research facilities

    Energy Technology Data Exchange (ETDEWEB)

    Nascimento, C.S. do, E-mail: claudio.souza@ctmsp.mar.mil.br [Centro Tecnológico da Marinha em São Paulo (CTMSP), Av. Professor Lineu Prestes 2468, 05508-000 São Paulo, SP (Brazil); Andrade, D.A., E-mail: delvonei@ipen.br [Instituto de Pesquisas Energéticas e Nucleares (IPEN/CNEN – SP), Av. Professor Lineu Prestes 2242, 05508-000 São Paulo, SP (Brazil); Mesquita, R.N. de, E-mail: rnavarro@ipen.br [Instituto de Pesquisas Energéticas e Nucleares (IPEN/CNEN – SP), Av. Professor Lineu Prestes 2242, 05508-000 São Paulo, SP (Brazil)

    2017-04-01

    Highlights: • A psychometric model to evaluate ‘safety climate’ at nuclear research facilities. • The model presented evidences of good psychometric qualities. • The model was applied to nuclear research facilities in Brazil. • Some ‘safety culture’ weaknesses were detected in the assessed organization. • A potential tool to develop safety management programs in nuclear facilities. - Abstract: A safe and reliable operation of nuclear power plants depends not only on technical performance, but also on the people and on the organization. Organizational factors have been recognized as the main causal mechanisms of accidents by research organizations through USA, Europe and Japan. Deficiencies related with these factors reveal weaknesses in the organization’s safety culture. A significant number of instruments to assess the safety culture based on psychometric models that evaluate safety climate through questionnaires, and which are based on reliability and validity evidences, have been published in health and ‘safety at work’ areas. However, there are few safety culture assessment instruments with these characteristics (reliability and validity) available on nuclear literature. Therefore, this work proposes an instrument to evaluate, with valid and reliable measures, the safety climate of nuclear research facilities. The instrument was developed based on methodological principles applied to research modeling and its psychometric properties were evaluated by a reliability analysis and validation of content, face and construct. The instrument was applied to an important nuclear research organization in Brazil. This organization comprises 4 research reactors and many nuclear laboratories. The survey results made possible a demographic characterization and the identification of some possible safety culture weaknesses and pointing out potential areas to be improved in the assessed organization. Good evidence of reliability with Cronbach's alpha

  4. Status of the Holifield Heavy Ion Research Facility

    International Nuclear Information System (INIS)

    Martin, J.A.

    1978-01-01

    The Holifield Heavy Ion Research Facility presently operates the Oak Ridge Isochronous Cyclotron (ORIC). This accelerator provides heavy ions up to argon with energies useful for nuclear physics. The Phase I expansion of this facility, now a year away from completion, includes a 25-MV vertical folded tandem accelerator, beam transport and injection systems to use the ORIC as an energy booster, and additional experiment areas for the beams directly from the tandem. The tandem--cyclotron combination will provide heavy ions with energies up to 25 MeV/A for A 11 particles/sec. Building construction for the project is essentially complete. The accelerator manufacturer, National Electrostatics Corporation, has completed installation and testing of the 10-m-diam by 30-m-high accelerator pressure vessel and has begun installation of the accelerator systems. The accelerator has previously been assembled at the NEC plant and the digital control system operated without voltage on the column. Voltage tests are expected to begin in Oak Ridge in January 1979 with beam tests to begin in March. Completion of the project, including acceptance tests of the tandem and the beam injection system for ORIC is presently scheduled for November 15, 1979. Construction of Phase II for the facility wich will include a much larger booster cyclotron and additional research areas is expected to begin in 1982

  5. Clinical research in small genomically stratified patient populations.

    Science.gov (United States)

    Martin-Liberal, J; Rodon, J

    2017-07-01

    The paradigm of early drug development in cancer is shifting from 'histology-oriented' to 'molecularly oriented' clinical trials. This change can be attributed to the vast amount of tumour biology knowledge generated by large international research initiatives such as The Cancer Genome Atlas (TCGA) and the use of next generation sequencing (NGS) techniques developed in recent years. However, targeting infrequent molecular alterations entails a series of special challenges. The optimal molecular profiling method, the lack of standardised biological thresholds, inter- and intra-tumor heterogeneity, availability of enough tumour material, correct clinical trials design, attrition rate, logistics or costs are only some of the issues that need to be taken into consideration in clinical research in small genomically stratified patient populations. This article examines the most relevant challenges inherent to clinical research in these populations. Moreover, perspectives from the Academia point of view are reviewed as well as initiatives to be taken in forthcoming years. Copyright © 2017 Elsevier Ltd. All rights reserved.

  6. Construction of a Solid State Research Facility, Building 3150

    International Nuclear Information System (INIS)

    1993-07-01

    The Department of Energy (DOE) proposes to construct a new facility to house the Materials Synthesis Group (MSG) and the Semiconductor Physics Group (SPG) of the Solid State Division, Oak Ridge National Laboratory (ORNL). The location of the proposed action is Roane County, Tennessee. MSG is involved in the study of crystal growth and the preparation and characterization of advanced materials, such as high-temperature superconductors, while SPG is involved in semiconductor physics research. All MSG and a major pardon of SPG research activities are now conducted in Building 2000, a deteriorating structure constructed in the 1940. The physical deterioration of the roof; the heating, ventilation, and air conditioning (HVAC) system; and the plumbing make this building inadequate for supporting research activities. The proposed project is needed to provide laboratory and office space for MSG and SPG and to ensure that research activities can continue without interruption due to deficiencies in the building and its associated utility systems

  7. Cost calculations for decommissioning and dismantling of nuclear research facilities

    International Nuclear Information System (INIS)

    Andersson, I.; Backe, S.; Cato, A.; Lindskog, S.; Efraimsson, H.; Iversen, Klaus; Salmenhaara, S.; Sjoeblom, R.

    2008-07-01

    Today, it is recommended that planning of decommission should form an integral part of the activities over the life cycle of a nuclear facility (planning, building and operation), but it was only in the nineteen seventies that the waste issue really surface. Actually, the IAEA guidelines on decommissioning have been issued as recently as over the last ten years, and international advice on finance of decommissioning is even younger. No general international guideline on cost calculations exists at present. This implies that cost calculations cannot be performed with any accuracy or credibility without a relatively detailed consideration of the radiological prerequisites. Consequently, any cost estimates based mainly on the particulars of the building structures and installations are likely to be gross underestimations. The present study has come about on initiative by the Swedish Nuclear Power Inspectorate (SKI) and is based on a common need in Denmark, Finland, Norway and Sweden. The content of the report may be briefly summarised as follows. The background covers design and operation prerequisites as well as an overview of the various nuclear research facilities in the four participating countries: Denmark, Finland, Norway and Sweden. The purpose of the work has been to identify, compile and exchange information on facilities and on methodologies for cost calculation with the aim of achieving an 80 % level of confidence. The scope has been as follows: 1) to establish a Nordic network 2) to compile dedicated guidance documents on radiological surveying, technical planning and financial risk identification and assessment 3) to compile and describe techniques for precise cost calculations at early stages 4) to compile plant and other relevant data A separate section is devoted in the report to good practice for the specific purpose of early but precise cost calculations for research facilities, and a separate section is devoted to techniques for assessment of cost

  8. Cost calculations for decommissioning and dismantling of nuclear research facilities

    Energy Technology Data Exchange (ETDEWEB)

    Andersson, I. (Studsvik Nuclear AB (Sweden)); Backe, S. (Institute for Energy Technology (Norway)); Cato, A.; Lindskog, S. (Swedish Nuclear Power Inspectorate (Sweden)); Efraimsson, H. (Swedish Radiation Protection Authority (Sweden)); Iversen, Klaus (Danish Decommissioning (Denmark)); Salmenhaara, S. (VTT Technical Research Centre of Finland (Finland)); Sjoeblom, R. (Tekedo AB, (Sweden))

    2008-07-15

    Today, it is recommended that planning of decommission should form an integral part of the activities over the life cycle of a nuclear facility (planning, building and operation), but it was only in the nineteen seventies that the waste issue really surface. Actually, the IAEA guidelines on decommissioning have been issued as recently as over the last ten years, and international advice on finance of decommissioning is even younger. No general international guideline on cost calculations exists at present. This implies that cost calculations cannot be performed with any accuracy or credibility without a relatively detailed consideration of the radiological prerequisites. Consequently, any cost estimates based mainly on the particulars of the building structures and installations are likely to be gross underestimations. The present study has come about on initiative by the Swedish Nuclear Power Inspectorate (SKI) and is based on a common need in Denmark, Finland, Norway and Sweden. The content of the report may be briefly summarised as follows. The background covers design and operation prerequisites as well as an overview of the various nuclear research facilities in the four participating countries: Denmark, Finland, Norway and Sweden. The purpose of the work has been to identify, compile and exchange information on facilities and on methodologies for cost calculation with the aim of achieving an 80 % level of confidence. The scope has been as follows: 1) to establish a Nordic network 2) to compile dedicated guidance documents on radiological surveying, technical planning and financial risk identification and assessment 3) to compile and describe techniques for precise cost calculations at early stages 4) to compile plant and other relevant data A separate section is devoted in the report to good practice for the specific purpose of early but precise cost calculations for research facilities, and a separate section is devoted to techniques for assessment of cost

  9. Radiological Characterization and Final Facility Status Report Tritium Research Laboratory

    International Nuclear Information System (INIS)

    Garcia, T.B.; Gorman, T.P.

    1996-08-01

    This document contains the specific radiological characterization information on Building 968, the Tritium Research Laboratory (TRL) Complex and Facility. We performed the characterization as outlined in its Radiological Characterization Plan. The Radiological Characterization and Final Facility Status Report (RC ampersand FFSR) provides historic background information on each laboratory within the TRL complex as related to its original and present radiological condition. Along with the work outlined in the Radiological Characterization Plan (RCP), we performed a Radiological Soils Characterization, Radiological and Chemical Characterization of the Waste Water Hold-up System including all drains, and a Radiological Characterization of the Building 968 roof ventilation system. These characterizations will provide the basis for the Sandia National Laboratory, California (SNL/CA) Site Termination Survey .Plan, when appropriate

  10. A research on threat (hazard) categorization method for nuclear facilities

    International Nuclear Information System (INIS)

    Tang Rongyao; Xu Xiaoxiao; Zhang Jiangang; Zhao Bin; Wang Xuexin

    2011-01-01

    The threat categorization method suggested by International Atomic Energy Agency (IAEA) and hazard categorization standard by the Department of Energy of United States (USDOE) for nuclear facilities are compared and discussed in this paper. The research shows the two types of categorization method for nuclear facilities are similar, though each has its own specialty. The categorization method suggested by IAEA for the purpose of emergency planning is quite completed and updated. The categorization method of DOE is advanced in its operability, and fits for safety surveillance. But the dispersible radioactive material thresholds used for categorization need to be updated. The threshold of category 3 is somewhat disputable for many reasons. The recommended categorization method for China is also given in this paper. (author)

  11. Thermal fuel research and development facilities in BNFL

    International Nuclear Information System (INIS)

    Roberts, V.A.; Vickers, J.

    1996-01-01

    BNFL is committed to providing high quality, cost effective nuclear fuel cycle services to customers on a National and International level. BNFL's services, products and expertise span the complete fuel cycle; from fuel manufacture through to fuel reprocessing, transport, waste management and decommissioning and the Company maintains its technical and commercial lead by investment in continued research and development (R and D). This paper discusses BNFL's involvement in R and D and gives an account of the current facilities available together with a description of the advanced R and D facilities constructed or planned at Springfields and Sellafield. It outlines the work being carried out to support the company fuel technology business, to (1) develop more cost effective routes to existing fuel products; (2) maximize the use of recycled uranium, plutonium and tails uranium and (3) support a successful MOX business

  12. 77 FR 60706 - National Human Genome Research Institute; Notice of Closed Meeting

    Science.gov (United States)

    2012-10-04

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Human Genome... unwarranted invasion of personal privacy. Name of Committee: National Human Genome Research Institute Special.... Nakamura, Ph.D., Scientific Review Officer, Scientific Review Branch, National Human Genome Research...

  13. 76 FR 19780 - National Human Genome Research Institute; Notice of Closed Meeting

    Science.gov (United States)

    2011-04-08

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Human Genome... E. Day, PhD, Scientific Review Officer, CIDR, National Human Genome Research Institute, National... . (Catalogue of Federal Domestic Assistance Program No. 93.172, Human Genome Research, National Institutes of...

  14. 76 FR 3917 - National Human Genome Research Institute; Notice of Closed Meeting

    Science.gov (United States)

    2011-01-21

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Human Genome... unwarranted invasion of personal privacy. Name of Committee: National Human Genome Research Institute Special... Branch, National Human Genome Research Institute, 5635 Fishers Lane, Suite 4076, MSC 9306, Rockville, MD...

  15. 75 FR 56115 - National Human Genome Research Institute; Notice of Closed Meeting

    Science.gov (United States)

    2010-09-15

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Human Genome... unwarranted invasion of personal privacy. Name of Committee: National Human Genome Research Institute Special... Federal Domestic Assistance Program Nos. 93.172, Human Genome Research, National Institutes of Health, HHS...

  16. 76 FR 3643 - National Human Genome Research Institute; Notice of Closed Meeting

    Science.gov (United States)

    2011-01-20

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Human Genome... unwarranted invasion of personal privacy. Name of Committee: National Human Genome Research Institute Initial... . (Catalogue of Federal Domestic Assistance Program Nos. 93.172, Human Genome Research, National Institutes of...

  17. 78 FR 24223 - National Human Genome Research Institute; Notice of Closed Meeting

    Science.gov (United States)

    2013-04-24

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Human Genome... unwarranted invasion of personal privacy. Name of Committee: National Human Genome Research Institute Initial...: To review and evaluate grant applications. Place: National Human Genome Research Institute, 3rd floor...

  18. 77 FR 2304 - National Human Genome Research Institute; Notice of Meeting

    Science.gov (United States)

    2012-01-17

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Human Genome....S.C. 281(d)(4)), notice is hereby given that the National Human Genome Research Institute (NHGRI... meeting of the National Advisory Council for Human Genome Research. Background materials on the proposed...

  19. 78 FR 21382 - National Human Genome Research Institute; Notice of Closed Meeting

    Science.gov (United States)

    2013-04-10

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Human Genome... applications. Place: National Human Genome Research Institute, Suite 4076, 5635 Fisher's Lane, Bethesda, MD..., National Human Genome Research Institute, National Institutes of Health, 5635 Fishers Lane, Suite 4075...

  20. 78 FR 20933 - National Human Genome Research Institute; Notice of Closed Meeting

    Science.gov (United States)

    2013-04-08

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Human Genome... unwarranted invasion of personal privacy. Name of Committee: National Human Genome Research Institute Special... review and evaluate grant applications. Place: National Human Genome Research Institute, Room 3055, 5635...

  1. 76 FR 22112 - National Human Genome Research Institute; Notice of Closed Meeting

    Science.gov (United States)

    2011-04-20

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Human Genome... unwarranted invasion of personal privacy. Name of Committee: National Human Genome Research Institute Special....nih.gov . (Catalogue of Federal Domestic Assistance Program Nos. 93.172, Human Genome Research...

  2. 78 FR 31953 - National Human Genome Research Institute; Notice of Closed Meeting

    Science.gov (United States)

    2013-05-28

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Human Genome... unwarranted invasion of personal privacy. Name of Committee: National Human Genome Research Institute Special... review and evaluate grant applications. Place: National Human Genome Research Institute, 3rd Floor...

  3. 75 FR 10488 - National Human Genome Research Institute; Notice of Closed Meetings

    Science.gov (United States)

    2010-03-08

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Human Genome... clearly unwarranted invasion of personal privacy. Name of Committee: National Human Genome Research...- 4280, [email protected]gov . Name of Committee: National Human Genome Research Institute Special...

  4. 76 FR 35224 - National Human Genome Research Institute; Notice of Closed Meeting

    Science.gov (United States)

    2011-06-16

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Human Genome...). Contact Person: Camilla E. Day, PhD, Scientific Review Officer, CIR, National Human Genome Research..., [email protected] . (Catalogue of Federal Domestic Assistance Program Nos. 93.172, Human Genome Research...

  5. 75 FR 8373 - National Human Genome Research Institute; Notice of Closed Meeting

    Science.gov (United States)

    2010-02-24

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Human Genome... unwarranted invasion of personal privacy. Name of Committee: National Human Genome Research Institute [email protected] . (Catalogue of Federal Domestic Assistance Program Nos. 93.172, Human Genome Research...

  6. 77 FR 22332 - National Human Genome Research Institute; Notice of Closed Meeting

    Science.gov (United States)

    2012-04-13

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Human Genome... unwarranted invasion of personal privacy. Name of Committee: National Human Genome Research Institute Special.... Agenda: To review and evaluate grant applications. Place: National Human Genome Research Institute, 5635...

  7. 76 FR 22407 - National Human Genome Research Institute; Notice of Closed Meeting

    Science.gov (United States)

    2011-04-21

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Human Genome... unwarranted invasion of personal privacy. Name of Committee: National Human Genome Research Institute Special.... (Catalogue of Federal Domestic Assistance Program Nos. 93.172, Human Genome Research, National Institutes of...

  8. 77 FR 8268 - National Human Genome Research Institute; Notice of Closed Meetings

    Science.gov (United States)

    2012-02-14

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Human Genome... applications. Place: National Human Genome Research Institute, 5635 Fisher's Lane, Room 4076, Rockville, MD..., CIDR, National Human Genome Research Institute, National Institutes of Health, 5635 Fishers Lane, Suite...

  9. 75 FR 48977 - National Human Genome Research Institute; Notice of Closed Meeting

    Science.gov (United States)

    2010-08-12

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Human Genome.... Contact Person: Camilla E. Day, PhD, Scientific Review Officer, CIDR, National Human Genome Research..., [email protected] . (Catalogue of Federal Domestic Assistance Program Nos. 93.172, Human Genome Research...

  10. 77 FR 74676 - National Human Genome Research Institute; Notice of Closed Meeting

    Science.gov (United States)

    2012-12-17

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Human Genome... Human Genome Research Institute, National Institutes of Health, 5635 Fishers Lane, Suite 4075, Bethesda.... 93.172, Human Genome Research, National Institutes of Health, HHS) Dated: December 11, 2012. David...

  11. 75 FR 19984 - National Human Genome Research Institute; Notice of Closed Meetings

    Science.gov (United States)

    2010-04-16

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Human Genome..., National Human Genome Research Institute, National Institutes of Health, 5635 Fishers Lane, Suite 4075... Nakamura, PhD, Scientific Review Officer, Scientific Review Branch, National Human Genome Research...

  12. 75 FR 26762 - National Human Genome Research Institute; Notice of Closed Meeting

    Science.gov (United States)

    2010-05-12

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Human Genome... unwarranted invasion of personal privacy. Name of Committee: National Human Genome Research Institute Initial... . (Catalogue of Federal Domestic Assistance Program Nos. 93.172, Human Genome Research, National Institutes of...

  13. 75 FR 44800 - National Human Genome Research Institute; Notice of Closed Meeting

    Science.gov (United States)

    2010-07-29

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Human Genome... for Human Genome Research. The meeting will be closed to the public in accordance with the provisions... Committee: National Advisory Council for Human Genome Research. Date: August 18, 2010. Time: 1 p.m. to 3 p.m...

  14. 75 FR 35821 - National Human Genome Research Institute; Notice of Closed Meeting

    Science.gov (United States)

    2010-06-23

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Human Genome... Person: Camilla E. Day, PhD, Scientific Review Officer, CIDR, National Human Genome Research [email protected] . (Catalogue of Federal Domestic Assistance Program Nos. 93.172, Human Genome Research...

  15. 76 FR 3642 - National Human Genome Research Institute; Notice of Closed Meetings

    Science.gov (United States)

    2011-01-20

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Human Genome... clearly unwarranted invasion of personal privacy. Name of Committee: National Human Genome Research....nih.gov . Name of Committee: National Human Genome Research Institute Special Emphasis Panel eMERGE...

  16. 78 FR 47715 - National Human Genome Research Institute; Notice of Closed Meeting

    Science.gov (United States)

    2013-08-06

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Human Genome... Person: Camilla E. Day, Ph.D., Scientific Review Officer, CIDR, National Human Genome Research [email protected] . (Catalogue of Federal Domestic Assistance Program Nos. 93.172, Human Genome Research...

  17. 77 FR 31863 - National Human Genome Research Institute; Notice of Closed Meeting

    Science.gov (United States)

    2012-05-30

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Human Genome... unwarranted invasion of personal privacy. Name of Committee: National Human Genome Research Institute Special..., Human Genome Research, National Institutes of Health, HHS) Dated: May 22, 2012. Jennifer S. Spaeth...

  18. 75 FR 52537 - National Human Genome Research Institute; Notice of Closed Meeting

    Science.gov (United States)

    2010-08-26

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Human Genome... unwarranted invasion of personal privacy. Name of Committee: National Human Genome Research Institute Initial....nih.gov . (Catalogue of Federal Domestic Assistance Program Nos. 93.172, Human Genome Research...

  19. 76 FR 79199 - National Human Genome Research Institute; Notice of Closed Meeting

    Science.gov (United States)

    2011-12-21

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Human Genome.... Contact Person: Camilla E. Day, Ph.D., Scientific Review Officer, CIDR, National Human Genome Research..., [email protected] . (Catalogue of Federal Domestic Assistance Program Nos. 93.172, Human Genome Research...

  20. 75 FR 2148 - National Human Genome Research Institute; Notice of Closed Meeting

    Science.gov (United States)

    2010-01-14

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Human Genome... unwarranted invasion of personal privacy. Name of Committee: National Human Genome Research Institute Initial....nih.gov . (Catalogue of Federal Domestic Assistance Program Nos. 93.172, Human Genome Research...

  1. 76 FR 66731 - National Human Genome Research Institute; Notice of Closed Meeting

    Science.gov (United States)

    2011-10-27

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Human Genome... unwarranted invasion of personal privacy. Name of Committee: National Human Genome Research Institute Special... Program Nos. 93.172, Human Genome Research, National Institutes of Health, HHS) Dated: October 21, 2011...

  2. 76 FR 10909 - National Human Genome Research Institute; Notice of Closed Meeting

    Science.gov (United States)

    2011-02-28

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Human Genome..., National Human Genome Research Institute, National Institutes of Health, 5635 Fishers Lane, Suite 4076, MSC..., Human Genome Research, National Institutes of Health, HHS). Dated: February 18, 2011. Jennifer S. Spaeth...

  3. 76 FR 36930 - National Human Genome Research Institute; Notice of Closed Meeting

    Science.gov (United States)

    2011-06-23

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Human Genome... unwarranted invasion of personal privacy. Name of Committee: National Human Genome Research Institute Special..., Human Genome Research, National Institutes of Health, HHS) Dated: June 17, 2011. Jennifer S. Spaeth...

  4. 77 FR 35991 - National Human Genome Research Institute; Notice of Closed Meeting

    Science.gov (United States)

    2012-06-15

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Human Genome... Human Genome Research Institute, National Institutes of Health, 5635 Fishers Lane, Suite 4075, Bethesda.... 93.172, Human Genome Research, National Institutes of Health, HHS) Dated: June 8, 2012. Jennifer S...

  5. 77 FR 61770 - National Human Genome Research Institute; Notice of Closed Meeting

    Science.gov (United States)

    2012-10-11

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Human Genome... unwarranted invasion of personal privacy. Name of Committee: National Human Genome Research Institute Special... Assistance Program Nos. 93.172, Human Genome Research, National Institutes of Health, HHS) [[Page 61771...

  6. 76 FR 63932 - National Human Genome Research Institute; Notice of Closed Meeting

    Science.gov (United States)

    2011-10-14

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Human Genome... unwarranted invasion of personal privacy. Name of Committee: National Human Genome Research Institute Special... Assistance Program Nos. 93.172, Human Genome Research, National Institutes of Health, HHS) Dated: October 7...

  7. 75 FR 8977 - National Human Genome Research Institute; Notice of Closed Meeting

    Science.gov (United States)

    2010-02-26

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Human Genome..., National Human Genome Research Institute, National Institutes of Health, 5635 Fishers Lane, Suite 4076, MSC..., Human Genome Research, National Institutes of Health, HHS) Dated: February 18, 2010. Jennifer Spaeth...

  8. 78 FR 66752 - National Human Genome Research Institute; Amended Notice of Meeting

    Science.gov (United States)

    2013-11-06

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Human Genome... National Human Genome Research Institute Special Emphasis Panel, October 15, 2013, 01:00 p.m. to October 15, 2013, 02:30 p.m., National Human Genome Research Institute, 5635 Fishers Lane, Suite 3055, Rockville...

  9. 75 FR 32957 - National Human Genome Research Institute; Notice of Closed Meeting

    Science.gov (United States)

    2010-06-10

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Human Genome... unwarranted invasion of personal privacy. Name of Committee: National Human Genome Research Institute Special... funding cycle. (Catalogue of Federal Domestic Assistance Program Nos. 93.172, Human Genome Research...

  10. 78 FR 14806 - National Human Genome Research Institute; Notice of Closed Meeting

    Science.gov (United States)

    2013-03-07

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Human Genome... unwarranted invasion of personal privacy. Name of Committee: National Human Genome Research Institute Special... p.m. Agenda: To review and evaluate grant applications. Place: National Human Genome Research...

  11. 75 FR 53703 - National Human Genome Research Institute; Notice of Closed Meeting

    Science.gov (United States)

    2010-09-01

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Human Genome..., Scientific Review Branch, National Human Genome Research Institute, National Institutes of Health, 5635.... (Catalogue of Federal Domestic Assistance Program Nos. 93.172, Human Genome Research, National Institutes of...

  12. 75 FR 67380 - National Human Genome Research Institute; Notice of Closed Meeting

    Science.gov (United States)

    2010-11-02

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Human Genome... Review Branch, National Human Genome Research Institute, National Institutes of Health, 5635 Fishers Lane.... (Catalogue of Federal Domestic Assistance Program Nos. 93.172, Human Genome Research, National Institutes of...

  13. Training and research reactor facility longevity extension program

    International Nuclear Information System (INIS)

    Carriveau, G.W.

    1991-01-01

    Since 1943, over 550 training and research reactors have been in operation. According to statistics from the International Atomic Energy Agency, ∼325 training and research reactors are currently in service. This total includes a wide variety of designs covering a range of power and research capabilities located virtually around the world. A program has been established at General Atomics (GA) that is dedicated to the support of extended longevity of training and research reactor facilities. Aspects of this program include the following: (1) new instrumentation and control systems; (2) improved and upgraded nuclear monitoring and control channels; (3) facility testing, repair and upgrade services that include (a) pool or tank integrity, (b) cooling system, and (c) water purification system; (4) fuel element testing procedures and replacement; (5) control rod drive rebuilding and upgrades; (6) control and monitoring system calibration and repair service; (7) training services, including reactor operations, maintenance, instrumentation calibration, and repair; and (8) expanded or new uses such as neutron radiography and autoradiography, isotope production, nuclear medicine, activation analysis, and material properties modification

  14. Nanotechnology on a dime: building affordable research facilities

    Science.gov (United States)

    DiBattista, Jeff; Clare, Donna; Lynch, David

    2005-08-01

    Designing buildings to house nanotechnology research presents a multitude of well-recognized challenges to architectural and engineering design teams, from environmental control to spatial arrangements to operational functionality. These technical challenges can be solved with relative ease on projects with large budgets: designers have the option of selecting leading-edge systems without undue regard for their expense. This is reflected in the construction cost of many nanotechnology research facilities that run well into the hundreds of millions of dollars. Smaller universities and other institutions need not be shut out of the nanotechnology research field simply because their construction budgets are tens of millions of dollars or less. The key to success for these less expensive projects lies with making good strategic decisions: identifying priorities for the facility in terms of what it will is--and will not--provide to the researchers. Making these strategic decisions puts bounds on the tactical, technical problems that the design team at large must address, allowing them to focus their efforts on the key areas for success. The process and challenges of this strategic decision-making process are examined, with emphasis placed on the types of decisions that must be made and the factors that must be considered when making them. Case study examples of projects undertaken at the University of Alberta are used to illustrate how strategic-level decision-making sets the stage for cutting-edge success on a modest budget.

  15. First Materials Science Research Facility Rack Capabilities and Design Features

    Science.gov (United States)

    Cobb, S.; Higgins, D.; Kitchens, L.; Curreri, Peter (Technical Monitor)

    2002-01-01

    The first Materials Science Research Rack (MSRR-1) is the primary facility for U.S. sponsored materials science research on the International Space Station. MSRR-1 is contained in an International Standard Payload Rack (ISPR) equipped with the Active Rack Isolation System (ARIS) for the best possible microgravity environment. MSRR-1 will accommodate dual Experiment Modules and provide simultaneous on-orbit processing operations capability. The first Experiment Module for the MSRR-1, the Materials Science Laboratory (MSL), is an international cooperative activity between NASA's Marshall Space Flight Center (MSFC) and the European Space Agency's (ESA) European Space Research and Technology Center (ESTEC). The MSL Experiment Module will accommodate several on-orbit exchangeable experiment-specific Module Inserts which provide distinct thermal processing capabilities. Module Inserts currently planned for the MSL are a Quench Module Insert, Low Gradient Furnace, and a Solidification with Quench Furnace. The second Experiment Module for the MSRR-1 configuration is a commercial device supplied by MSFC's Space Products Development (SPD) Group. Transparent furnace assemblies include capabilities for vapor transport processes and annealing of glass fiber preforms. This Experiment Module is replaceable on-orbit. This paper will describe facility capabilities, schedule to flight and research opportunities.

  16. ARM Climate Research Facility: Outreach Tools and Strategies

    Science.gov (United States)

    Roeder, L.; Jundt, R.

    2009-12-01

    Sponsored by the Department of Energy, the ARM Climate Research Facility is a global scientific user facility for the study of climate change. To publicize progress and achievements and to reach new users, the ACRF uses a variety of Web 2.0 tools and strategies that build off of the program’s comprehensive and well established News Center (www.arm.gov/news). These strategies include: an RSS subscription service for specific news categories; an email “newsletter” distribution to the user community that compiles the latest News Center updates into a short summary with links; and a Facebook page that pulls information from the News Center and links to relevant information in other online venues, including those of our collaborators. The ACRF also interacts with users through field campaign blogs, like Discovery Channel’s EarthLive, to share research experiences from the field. Increasingly, field campaign Wikis are established to help ACRF researchers collaborate during the planning and implementation phases of their field studies and include easy to use logs and image libraries to help record the campaigns. This vital reference information is used in developing outreach material that is shared in highlights, news, and Facebook. Other Web 2.0 tools that ACRF uses include Google Maps to help users visualize facility locations and aircraft flight patterns. Easy-to-use comment boxes are also available on many of the data-related web pages on www.arm.gov to encourage feedback. To provide additional opportunities for increased interaction with the public and user community, future Web 2.0 plans under consideration for ACRF include: evaluating field campaigns for Twitter and microblogging opportunities, adding public discussion forums to research highlight web pages, moving existing photos into albums on FlickR or Facebook, and building online video archives through YouTube.

  17. 78 FR 68856 - National Human Genome Research Institute; Notice of Closed Meeting

    Science.gov (United States)

    2013-11-15

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Human Genome... Nakamura, Ph.D., Scientific Review Officer, Scientific Review Branch, National Human Genome Research...-402-0838. [[Page 68857

  18. MYRRHA. An experimental ADS Facility for Research and Development

    International Nuclear Information System (INIS)

    Ait Abderrahim, H.

    2006-01-01

    Full text of publication follows: Since 1998, SCK-CEN in partnership with IBA s.a. and many European research laboratories, is designing a multipurpose ADS for R and D applications MYRRHA - and is conducting an associated R and D support programme. MYRRHA is an Accelerator Driven System (ADS) under development at Mol in Belgium and aiming to serve as a basis for the European experimental ADS to provide protons and neutrons for various R and D applications. It consists of a proton accelerator delivering a 350 MeV * 5 mA proton beam to a liquid Pb-Bi spallation target that in turn couples to a Pb-Bi cooled, subcritical fast core. In a first stage, the project focuses mainly on demonstration of the ADS concept, safety research on sub-critical systems and nuclear waste transmutation studies. In a later stage, the device will also be dedicated to research on structural materials, nuclear fuel, liquid metal technology and associated aspects and on sub-critical reactor physics. Subsequently, it will be used as fast spectrum irradiation facility and as radioisotope production facility. Along the above design features, the MYRRHA project team is developing the MYRRHA project as a multipurpose irradiation facility for R and D applications on the basis of an Accelerator Driven System (ADS). The project is intended to fit into the European strategy towards an ADS Demo facility for nuclear waste transmutation as described in the PDS-XADS FP5 Project. As such it should serve the following task catalogue: ADS concept demonstration, Safety studies for ADS, MA transmutation studies, LLFP transmutation studies, Medical radioisotopes, Material research, Fuel research. A first preliminary conceptual design file of MYRRHA was completed by the end of 2001 and has been reviewed by an International Technical Guidance Committee that concluded that there are no show stoppers in the project even thought some topics such as the safety studies and the fuel qualification need to be addressed

  19. Genomic research and wide data sharing: views of prospective participants.

    Science.gov (United States)

    Trinidad, Susan Brown; Fullerton, Stephanie M; Bares, Julie M; Jarvik, Gail P; Larson, Eric B; Burke, Wylie

    2010-08-01

    Sharing study data within the research community generates tension between two important goods: promoting scientific goals and protecting the privacy interests of study participants. This study was designed to explore the perceptions, beliefs, and attitudes of research participants and possible future participants regarding genome-wide association studies and repository-based research. Focus group sessions with (1) current research participants, (2) surrogate decision-makers, and (3) three age-defined cohorts (18-34 years, 35-50, >50). Participants expressed a variety of opinions about the acceptability of wide sharing of genetic and phenotypic information for research purposes through large, publicly accessible data repositories. Most believed that making de-identified study data available to the research community is a social good that should be pursued. Privacy and confidentiality concerns were common, although they would not necessarily preclude participation. Many participants voiced reservations about sharing data with for-profit organizations. Trust is central in participants' views regarding data sharing. Further research is needed to develop governance models that enact the values of stewardship.

  20. Neutron beam facilities at the Replacement Research Reactor, ANSTO

    International Nuclear Information System (INIS)

    Kim, S.

    2003-01-01

    The exciting development for Australia is the construction of a modern state-of-the-art 20-MW Replacement Research Reactor which is currently under construction to replace the aging reactor (HIFAR) at ANSTO in 2006. To cater for advanced scientific applications, the replacement reactor will provide not only thermal neutron beams but also a modern cold-neutron source moderated by liquid deuterium at approximately -250 deg C, complete with provision for installation of a hot-neutron source at a later stage. The latest 'supermirror' guides will be used to transport the neutrons to the Reactor Hall and its adjoining Neutron Guide Hall where a suite of neutron beam instruments will be installed. These new facilities will expand and enhance ANSTO's capabilities and performance in neutron beam science compared with what is possible with the existing HIFAR facilities, and will make ANSTO/Australia competitive with the best neutron facilities in the world. Eight 'leading-edge' neutron beam instruments are planned for the Replacement Research Reactor when it goes critical in 2006, followed by more instruments by 2010 and beyond. Up to 18 neutron beam instruments can be accommodated at the Replacement Research Reactor, however, it has the capacity for further expansion, including potential for a second Neutron Guide Hall. The first batch of eight instruments has been carefully selected in conjunction with a user group representing various scientific interests in Australia. A team of scientists, engineers, drafting officers and technicians has been assembled to carry out the Neutron Beam Instrument Project to successful completion. Today, most of the planned instruments have conceptual designs and are now being engineered in detail prior to construction and procurement. A suite of ancillary equipment will also be provided to enable scientific experiments at different temperatures, pressures and magnetic fields. This paper describes the Neutron Beam Instrument Project and gives

  1. Congressional hearing reviews NSF major research and facilities projects

    Science.gov (United States)

    Showstack, Randy

    2012-03-01

    An 8 March congressional hearing about the U.S. National Science Foundation's Major Research Equipment and Facilities Construction (NSF MREFC) account focused on fiscal management and accountability of projects in that account and reviewed concerns raised by NSF's Office of Inspector General (OIG). NSF established the MREFC account in 1995 to better plan and manage investments in major equipment and facilities projects, which can cost from tens of millions to hundreds of millions of dollars, and the foundation has funded 17 MREFC projects since then. The Obama administration's proposed fiscal year (FY) 2013 budget includes funding for four MREFC projects: Advanced Laser Gravitational-Wave Observatory (AdvLIGO), Advanced Technology Solar Telescope (ATST), National Ecological Observatory (NEON), and Ocean Observatories Initiative (OOI). The hearing, held by a subcommittee of the House of Representatives' Committee on Science, Space, and Technology, reviewed management oversight throughout the life cycles of MREFC projects and concerns raised in recent OIG reports about the use of budget contingency funds. NSF's February 2012 manual called "Risk management guide for large facilities" states that cost contingency is "that portion of the project budget required to cover `known unknowns,'" such as planning and estimating errors and omissions, minor labor or material price fluctuations, and design developments and changes within the project scope. Committee members acknowledged measures that NSF has made to improve the MREFC oversight process, but they also urged the agency to continue to take steps to ensure better project management.

  2. Cosmic muon flux measurements at the Kimballton Underground Research Facility

    International Nuclear Information System (INIS)

    Kalousis, L N; Guarnaccia, E; Link, J M; Mariani, C; Pelkey, R

    2014-01-01

    In this article, the results from a series of muon flux measurements conducted at the Kimballton Underground Research Facility (KURF), Virginia, United States, are presented. The detector employed for these investigations, is made of plastic scintillator bars readout by wavelength shifting fibers and multianode photomultiplier tubes. Data was taken at several locations inside KURF, spanning rock overburden values from ∼ 200 to 1450 m.w.e. From the extracted muon rates an empirical formula was devised, that estimates the muon flux inside the mine as a function of the overburden. The results are in good agreement with muon flux calculations based on analytical models and MUSIC

  3. 14MeV facility and research in IPPE

    Energy Technology Data Exchange (ETDEWEB)

    Simakov, S P; Androsenko, A A; Androsenko, P A; Devkin, B V; Kobozev, M G; Lychagin, A A; Sinitca, V V; Talalaev, V A [Institute of Physics and Power Engineering, Obninsk (Russian Federation); Chuvilin, D Yu; Borisov, A A; Zagryadsky, V A [Institute of Atomic Energy, Moscow (Russian Federation)

    1993-07-01

    Review of experimental facility and research, performed at 14MeV incident neutron energy in the Institute of Physics and Power Engineering, are given. These studies cover the next topics: double differential neutron emission cross sections (DDX), neutron-gamma coincidence experiments (n, n'{gamma}) and neutron leakage spectra for spherical assemblies (benchmark). The paper contains description and main parameters of pulsed neutron generator KG-0.3, fast neutron time of flight spectrometer, measuring and data reduction procedures, review of experimental data. Results of experiments are compared with other data; evaluated data files BROND-2, ENDF/B6, JENDL-3; basic theoretical and transport model calculations. (author)

  4. 14MeV facility and research in IPPE

    International Nuclear Information System (INIS)

    Simakov, S.P.; Androsenko, A.A.; Androsenko, P.A.; Devkin, B.V.; Kobozev, M.G.; Lychagin, A.A.; Sinitca, V.V.; Talalaev, V.A.; Chuvilin, D.Yu.; Borisov, A.A.; Zagryadsky, V.A.

    1993-07-01

    Review of experimental facility and research, performed at 14MeV incident neutron energy in the Institute of Physics and Power Engineering, are given. These studies cover the next topics: double differential neutron emission cross sections (DDX), neutron-gamma coincidence experiments (n, n'γ) and neutron leakage spectra for spherical assemblies (benchmark). The paper contains description and main parameters of pulsed neutron generator KG-0.3, fast neutron time of flight spectrometer, measuring and data reduction procedures, review of experimental data. Results of experiments are compared with other data; evaluated data files BROND-2, ENDF/B6, JENDL-3; basic theoretical and transport model calculations. (author)

  5. Nuclear Security Management for Research Reactors and Related Facilities

    International Nuclear Information System (INIS)

    2016-03-01

    This publication provides a single source guidance to assist those responsible for the implementation of nuclear security measures at research reactors and associated facilities in developing and maintaining an effective and comprehensive programme covering all aspects of nuclear security on the site. It is based on national experience and practices as well as on publications in the field of nuclear management and security. The scope includes security operations, security processes, and security forces and their relationship with the State’s nuclear security regime. The guidance is provided for consideration by States, competent authorities and operators

  6. Research reactor facilities, recent developments at Imperial College, London

    International Nuclear Information System (INIS)

    Franklin, S.J.; Goddard, A.J.H.; O Connell, J.

    1998-01-01

    The 100 kW CONSORT pool-type reactor is now the only Research Reactor in the UK. Because of its strategic importance, Imperial College is continuing and accelerating a programme of refurbishment of the control system, and planning for a further fuel charge. These plans are described and the progress to date discussed. To this end, a description of the enhanced Safety Case being written is provided here and refueling plans discussed. The current range of facilities available is described, and future plans highlighted. (author)

  7. The Sondrestrom Research Facility All-sky Imagers

    Science.gov (United States)

    Kendall, E. A.; Grill, M.; Gudmundsson, E.; Stromme, A.

    2010-12-01

    The Sondrestrom Upper Atmospheric Research Facility is located near Kangerlussuaq, Greenland, just north of the Arctic Circle and 100 km inland from the west coast of Greenland. The facility is operated by SRI International in Menlo Park, California, under the auspices of the U.S. National Science Foundation. Operating in Greenland since 1983, the Sondrestrom facility is host to more than 20 instruments, the majority of which provide unique and complementary information about the arctic upper atmosphere. Together these instruments advance our knowledge of upper atmospheric physics and determine how the tenuous neutral gas interacts with the charged space plasma environment. The suite of instrumentation supports many disciplines of research - from plate tectonics to auroral physics and space weather. The Sondrestrom facility has recently acquired two new all-sky imagers. In this paper, we present images from both new imagers, placing them in context with other instruments at the site and detailing to the community how to gain access to this new data set. The first new camera replaces the intensified auroral system which has been on site for nearly three decades. This new all-sky imager (ASI), designed and assembled by Keo Scientific Ltd., employs a medium format 180° fisheye lens coupled to a set of five 3-inch narrowband interference filters. The current filter suite allows operation at the following wavelengths: 750 nm, 557.7 nm, 777.4 nm, 630.0 nm, and 732/3 nm. Monochromatic images from the ASI are acquired at a specific filter and integration time as determined by a unique configuration file. Integrations as short as 0.5 sec can be commanded for exceptionally bright features. Preview images are posted to the internet in near real-time, with final images posted weeks later. While images are continuously collected in a "patrol mode," users can request special collection sequences for targeted experiments. The second new imager installed at the Sondrestrom

  8. Fusion plasma physics research on the H-1 national facility

    International Nuclear Information System (INIS)

    Harris, J.

    1998-01-01

    Full text: Australia has a highly leveraged fusion plasma research program centred on the H-1 National Facility device at the ANU. H-1 is a heliac, a novel helical axis stellarator that was experimentally pioneered in Australia, but has a close correlation with the worldwide research program on toroidal confinement of fusion grade plasma. Experiments are conducted on H-1 by university researchers from the Australian Fusion Research Group (comprising groups from the ANU, the Universities of Sydney, Western Sydney, Canberra, New England, and Central Queensland University) under the aegis of AINSE; the scientists also collaborate with fusion researchers from Japan and the US. Recent experiments on H-1 have focused on improved confinement modes that can be accessed at very low powers in H-1, but allow the study of fundamental physics effects seen on much larger machines at higher powers. H-1 is now being upgraded in magnetic field and heating power, and will be able to confine hotter plasmas beginning in 1999, offering greatly enhanced research opportunities for Australian plasma scientists and engineers, with substantial spillover of ideas from fusion research into other areas of applied physics and engineering

  9. Voting with their mice: personal genome testing and the "participatory turn" in disease research.

    Science.gov (United States)

    Prainsack, Barbara

    2011-05-01

    While the availability of genome tests on the internet has given rise to heated debates about the likely impact on personal genome information on test-takers, on insurance, and on healthcare systems, in this article I argue that a more tangible effect of personal genomics is that it has started to change how participation in disease research is conceived and enacted. I examine three models of research participation that personal genomics customers are encouraged to engage in. I conclude with an evaluation of the pitfalls and benefits of "crowdsourcing" genetic disease research in the context of personal genomics.

  10. Decommissioning of Medical, Industrial and Research Facilities. Safety Guide

    International Nuclear Information System (INIS)

    2010-01-01

    Radioactive waste is produced in the generation of nuclear power and the use of radioactive materials in industry, research and medicine. The importance of the safe management of radioactive waste for the protection of human health and the environment has long been recognized, and considerable experience has been gained in this field. The IAEA's Radioactive Waste Safety Standards Programme aimed at establishing a coherent and comprehensive set of principles and requirements for the safe management of waste and formulating the guidelines necessary for their application. This is accomplished within the IAEA Safety Standards Series in an internally consistent set of publications that reflect an international consensus. The publications will provide Member States with a comprehensive series of internationally agreed publications to assist in the derivation of, and to complement, national criteria, standards and practices. The Safety Standards Series consists of three categories of publications: Safety Fundamentals, Safety Requirements and Safety Guides. With respect to the Radioactive Waste Safety Standards Programme, the set of publications is currently undergoing review to ensure a harmonized approach throughout the Safety Standards Series. This Safety Guide addresses the subject of decommissioning of medical, industrial and research facilities where radioactive materials and sources are produced, received, used and stored. It is intended to provide guidance to national authorities and operating organizations, particularly to those in developing countries (as such facilities are predominant in these countries), for the planning and safe management of the decommissioning of such facilities. The Safety Guide has been prepared through a series of Consultants meetings and a Technical Committee meeting

  11. Decommissioning of medical, industrial and research facilities. Safety guide

    International Nuclear Information System (INIS)

    2005-01-01

    Radioactive waste is produced in the generation of nuclear power and the use of radioactive materials in industry, research and medicine. The importance of the safe management of radioactive waste for the protection of human health and the environment has long been recognized, and considerable experience has been gained in this field. The IAEA's Radioactive Waste Safety Standards Programme aimed at establishing a coherent and comprehensive set of principles and requirements for the safe management of waste and formulating the guidelines necessary for their application. This is accomplished within the IAEA Safety Standards Series in an internally consistent set of publications that reflect an international consensus. The publications will provide Member States with a comprehensive series of internationally agreed publications to assist in the derivation of, and to complement, national criteria, standards and practices. The Safety Standards Series consists of three categories of publications: Safety Fundamentals, Safety Requirements and Safety Guides. With respect to the Radioactive Waste Safety Standards Programme, the set of publications is currently undergoing review to ensure a harmonized approach throughout the Safety Standards Series. This Safety Guide addresses the subject of decommissioning of medical, industrial and research facilities where radioactive materials and sources are produced, received, used and stored. It is intended to provide guidance to national authorities and operating organizations, particularly to those in developing countries (as such facilities are predominant in these countries), for the planning and safe management of the decommissioning of such facilities. The Safety Guide has been prepared through a series of Consultants meetings and a Technical Committee meeting

  12. Spaces of genomics : exploring the innovation journey of genomics in research on common disease

    NARCIS (Netherlands)

    Bitsch, L.

    2013-01-01

    Genomics was introduced with big promises and expectations of its future contribution to our society. Medical genomics was introduced as that which would lay the foundation for a revolution in our management of common diseases. Genomics would lead the way towards a future of personalised medicine.

  13. diArk – a resource for eukaryotic genome research

    Directory of Open Access Journals (Sweden)

    Kollmar Martin

    2007-04-01

    Full Text Available Abstract Background The number of completed eukaryotic genome sequences and cDNA projects has increased exponentially in the past few years although most of them have not been published yet. In addition, many microarray analyses yielded thousands of sequenced EST and cDNA clones. For the researcher interested in single gene analyses (from a phylogenetic, a structural biology or other perspective it is therefore important to have up-to-date knowledge about the various resources providing primary data. Description The database is built around 3 central tables: species, sequencing projects and publications. The species table contains commonly and alternatively used scientific names, common names and the complete taxonomic information. For projects the sequence type and links to species project web-sites and species homepages are stored. All publications are linked to projects. The web-interface provides comprehensive search modules with detailed options and three different views of the selected data. We have especially focused on developing an elaborate taxonomic tree search tool that allows the user to instantaneously identify e.g. the closest relative to the organism of interest. Conclusion We have developed a database, called diArk, to store, organize, and present the most relevant information about completed genome projects and EST/cDNA data from eukaryotes. Currently, diArk provides information about 415 eukaryotes, 823 sequencing projects, and 248 publications.

  14. Research studies performed using the Cairo Fourier Diffractometer Facility

    International Nuclear Information System (INIS)

    Maayouf, R.M.A.; Ridikas, D.

    2009-12-01

    This report represents the results of the research studies performed using the Cairo Fourier Diffractometer Facility (CFDF), within 10 years after it was installed and put into operation at the beginning of 1996. The main components of the CFDF were supplied by the IAEA according to the technical assistance project EGY/1/022 'Upgrading of Research Reactor Utilization'. The present report is the second published INDC report, while the first one, published at the beginning of 1997, was about the performance of the CFDF and its main characteristic parameters. Plenty of measurements were performed since then, yielding several publications both in local and international scientific periodicals and resulting in 8 M.Sc. and Ph.D. degrees from Egyptian Universities. In addition, a new approach for the analysis of the neutron spectra was implemented using the CFDF. Specially designed interface card with proper software program was applied instead of the reverse time of flight (RTOF) and Finnish made analyzer originally attached to the facility. It has been verified that the new approach can successfully replace the RTOF analyzer, significantly decreasing the time of measurement and saving the reactor's operation time. Besides, a special fault diagnostic system program was developed and tested for caring and handling the possible failures of the CFDF. Moreover, measurements were carried out for the diffraction spectra emitted at different points of one of the samples. The latter was scanned across the neutron beam of the CFDF, for studying the stress after welding; used in industrial applications. (author)

  15. Importance of Pharmaceutical Training and Clinical Research at Medical Facilities.

    Science.gov (United States)

    Myotoku, Michiaki

    2017-01-01

    To respond to advancements in medical techniques, and to address the separation of medical and dispensary practices, clinical professors are required to educate human resource staff to become highly-skilled pharmacists. For this purpose, it is extremely important for these professors to learn about cutting-edge practical skills and knowledge, as well as to advance their expertise. In addition, they need to conduct clinical research in cooperation with relevant facilities. As our university does not have its own hospital or pharmacy, it is important to provide training for clinical professors in clinical facilities. Such training mainly involves medical teams' in-hospital rounds and participation in conferences (nutrition support team; NST), operation of the pharmacy department, and intervention targeting improvement in the department's duties. We have conducted collaborative studies, provided research instructions, implemented studies aimed at improving the department's work (pharmacists appointed on wards at all times to ensure medical safety) as well as studies regarding team medical care (nutritional evaluation during outpatient chemotherapy), and resolved issues regarding this work (drug solution mixability in a hand-held constant infusion pump, and a safe pump-filling methods). Thus, it has become possible to keep track of the current state of a pharmacists' work within team medical care, to access information about novel drugs, to view clinical and prescription-claim data, to cooperate with other professionals (e.g., doctors and nurses), to promote pharmacists' self-awareness of their roles in cooperative medical practice, and to effectively maintain the hospital's clinical settings.

  16. Brookhaven National Laboratory's Accelerator Test Facility: research highlights and plans

    Science.gov (United States)

    Pogorelsky, I. V.; Ben-Zvi, I.

    2014-08-01

    The Accelerator Test Facility (ATF) at Brookhaven National Laboratory has served as a user facility for accelerator science for over a quarter of a century. In fulfilling this mission, the ATF offers the unique combination of a high-brightness 80 MeV electron beam that is synchronized to a 1 TW picosecond CO2 laser. We unveil herein our plan to considerably expand the ATF's floor space with an upgrade of the electron beam's energy to 300 MeV and the CO2 laser's peak power to 100 TW. This upgrade will propel the ATF even further to the forefront of research on advanced accelerators and radiation sources, supporting the most innovative ideas in this field. We discuss emerging opportunities for scientific breakthroughs, including the following: plasma wakefield acceleration studies in research directions already active at the ATF; laser wakefield acceleration (LWFA), where the longer laser wavelengths are expected to engender a proportional increase in the beam's charge while our linac will assure, for the first time, the opportunity to undertake detailed studies of seeding and staging of the LWFA; proton acceleration to the 100-200 MeV level, which is essential for medical applications; and others.

  17. Quality Assurance of ARM Program Climate Research Facility Data

    Energy Technology Data Exchange (ETDEWEB)

    Peppler, RA; Kehoe, KE; Sonntag, KL; Bahrmann, CP; Richardson, SJ; Christensen, SW; McCord, RA; Doty, DJ; Wagener, Richard [BNL; Eagan, RC; Lijegren, JC; Orr, BW; Sisterson, DL; Halter, TD; Keck, NN; Long, CN; Macduff, MC; Mather, JH; Perez, RC; Voyles, JW; Ivey, MD; Moore, ST; Nitschke, DL; Perkins, BD; Turner, DD

    2008-03-01

    This report documents key aspects of the Atmospheric Radiation Measurement (ARM) Climate Research Facility (ACRF) data quality assurance program as it existed in 2008. The performance of ACRF instruments, sites, and data systems is measured in terms of the availability, usability, and accessibility of the data to a user. First, the data must be available to users; that is, the data must be collected by instrument systems, processed, and delivered to a central repository in a timely manner. Second, the data must be usable; that is, the data must be inspected and deemed of sufficient quality for scientific research purposes, and data users must be able to readily tell where there are known problems in the data. Finally, the data must be accessible; that is, data users must be able to easily find, obtain, and work with the data from the central repository. The processes described in this report include instrument deployment and calibration; instrument and facility maintenance; data collection and processing infrastructure; data stream inspection and assessment; the roles of value-added data processing and field campaigns in specifying data quality and haracterizing the basic measurement; data archival, display, and distribution; data stream reprocessing; and engineering and operations management processes and procedures. Future directions in ACRF data quality assurance also are presented.

  18. Introduction of hot cell facility in research center Rez - Poster

    International Nuclear Information System (INIS)

    Petrickova, A.; Srba, O.; Miklos, M.; Svoboda, P.

    2015-01-01

    This poster presents the hot cell facility which is being constructed as part of the SUSEN project at the Rez research center (Czech Republic). Within this project a new complex of 10 hot cells and one semi-hot cell will be built. There will be 8 gamma hot cells and 2 alpha hot cells. In each hot cell a hermetic, removable box made of stainless steel will home different type of devices. The hot cells and semi hot cell will be equipped with devices for processing samples (cutting, welding, drilling, machining) as well as equipment for testing (sample preparation area, stress testing machine, fatigue machine, electromechanical creep machine, high frequency resonance pulsator...) and equipment for studying material microstructure (nano-indenter with nano-scratch tester and scanning electron microscope). An autoclave with water loop, installed in a cell will allow mechanical testing in control environment of water, pressure and temperature. A scheme shows the equipment of each cell. This hot laboratory will be able to cover all the process to study radioactive materials: receiving the material, the preparation of the samples, mechanical testing and microstructure observation. Our hot cells will be close to the research nuclear reactor LVR-15 and new irradiation facility (high irradiation by cobalt source) is planned to be built within the SUSEN project

  19. Quality Assurance of ARM Program Climate Research Facility Data

    International Nuclear Information System (INIS)

    Peppler, R.A.; Kehoe, K.E.; Sonntag, K.L.; Bahramann, C.P.; Richardson, S.J.; Christensen, S.W.; McCord, R.A.; Doty, D.J.; Wagener, R.; Eagan, R.C.; Lijegren, J.C.; Orr, B.W.; Sisterson, D.L.; Halter, T.D.; Keck, N.N.; Long, C.N.; Macduff, M.C.; Mather, J.H.; Perez, R.C.; Voyles, J.W.; Ivey, M.D.; Moore, S.T.; Nitschke, D.L.; Perkins, B.D.; Turner, D.D.

    2008-01-01

    This report documents key aspects of the Atmospheric Radiation Measurement (ARM) Climate Research Facility (ACRF) data quality assurance program as it existed in 2008. The performance of ACRF instruments, sites, and data systems is measured in terms of the availability, usability, and accessibility of the data to a user. First, the data must be available to users; that is, the data must be collected by instrument systems, processed, and delivered to a central repository in a timely manner. Second, the data must be usable; that is, the data must be inspected and deemed of sufficient quality for scientific research purposes, and data users must be able to readily tell where there are known problems in the data. Finally, the data must be accessible; that is, data users must be able to easily find, obtain, and work with the data from the central repository. The processes described in this report include instrument deployment and calibration; instrument and facility maintenance; data collection and processing infrastructure; data stream inspection and assessment; the roles of value-added data processing and field campaigns in specifying data quality and characterizing the basic measurement; data archival, display, and distribution; data stream reprocessing; and engineering and operations management processes and procedures. Future directions in ACRF data quality assurance also are presented

  20. Magnetic spectrograph for the Holifield heavy ion research facility

    International Nuclear Information System (INIS)

    Ford, J.L.C. Jr.; Enge, H.A.; Erskine, J.R.; Hendrie, D.L.; LeVine, M.J.

    1977-01-01

    The need for a new generation magnetic spectrograph for the Holifield Heavy Ion Research Facility is discussed. The advantages of a magnetic spectrograph for heavy ion research are discussed, as well as some of the types of experiments for which such an instrument is suited. The limitations which the quality of the incident beam, target and spectrograph itself impose on high resolution heavy ion measurements are discussed. Desired features of an ideal new spectrograph are: (1) intrinsic resolving power E/ΔE greater than or equal to 3000; (2) maximum solid angle greater than or equal to 20 msr; (3) dispersion approx. 4-8m; (4) maximum energy interval approx. 30%; and (5) mass-energy product greater than or equal to 200. Various existing and proposed spectrographs are compared with the specifications for a new heavy ion magnet design

  1. H-1NF: Australian national fusion plasma research facility

    International Nuclear Information System (INIS)

    Blackwell, B.D.; Borg, G.G.; Dewar, R.L.; Howard, J.; Gardner, H.J.; Rudakov, D.L.; Sharp, L.E.; Shats, M.G.; Warr, G.B.

    1997-01-01

    The H-1 heliac is a helical axis stellarator of moderate size and novel, flexible configuration. Since commissioning, H-1 has operated in quasi-continuous mode at low magnetic field. For higher fields ≤1T an ECRH heating system (28GHz, 200kW) has been installed under a collaborative agreement between ANU and NIFS. H-1 has recently been promoted to national facility status (H-1NF), which will include upgrades of the rf and ech heating systems to megawatt powers, and power supply and diagnostic and data system enhancements. This facilitates collaborative research locally (through the Australian Fusion Research Group consortium) and internationally. Results of a number of basic experiments in quasi-continuous mode are presented. (author)

  2. High temperature engineering research facilities and experiments in Russia

    International Nuclear Information System (INIS)

    Kodochigov, N.G.; Kuzavkov, N.G.; Sukharev, Y.P.; Chudin, A.G.

    1998-01-01

    An overview is given of the characteristics of the experimental facilities and experiments in the Russian Federation: the HTGR neutron-physical investigation facilities ASTRA and GROG; facilities for fuel, graphite and other elements irradiation; and thermal hydraulics experimental facilities. The overview is presented in the form of copies of overhead sheets

  3. Integrative Genomics Viewer (IGV) | Informatics Technology for Cancer Research (ITCR)

    Science.gov (United States)

    The Integrative Genomics Viewer (IGV) is a high-performance visualization tool for interactive exploration of large, integrated genomic datasets. It supports a wide variety of data types, including array-based and next-generation sequence data, and genomic annotations.

  4. CSU's MWV Observatory: A Facility for Research, Education and Outreach

    Science.gov (United States)

    Hood, John; Carpenter, N. D.; McCarty, C. B.; Samford, J. H.; Johnson, M.; Puckett, A. W.; Williams, R. N.; Cruzen, S. T.

    2014-01-01

    The Mead Westvaco Observatory (MWVO), located in Columbus State University's Coca-Cola Space Science Center, is dedicated to education and research in astronomy through hands-on engagement and public participation. The MWVO has recently received funding to upgrade from a 16-inch Meade LX-200 telescope to a PlaneWave CDK 24-inch Corrected Dall-Kirkham Astrograph telescope. This and other technological upgrades will allow this observatory to stream live webcasts for astronomical events, allowing a worldwide public audience to become a part of the growing astronomical community. This poster will explain the upgrades that are currently in progress as well as the results from the current calibrations. The goal of these upgrades is to provide facilities capable of both research-class projects and widespread use in education and public outreach. We will present our initial calibration and tests of the observatory equipment, as well as its use in webcasts of astronomical events, in solar observing through the use of specialized piggy-backed telescopes, and in research into such topics as asteroids, planetary and nebula imaging. We will describe a pilot research project on asteroid orbit refinement and light curves, to be carried out by Columbus State University students. We will also outline many of the K-12 educational and public outreach activities we have designed for these facilities. Support and funding for the acquisition and installation of the new PlaneWave CDK 24 has been provided by the International Museum and Library Services via the Museums for America Award.

  5. Filling the gaps in SCWR materials research: advanced nuclear corrosion research facilities in Hamilton

    International Nuclear Information System (INIS)

    Krausher, J.L.; Zheng, W.; Li, J.; Guzonas, D.; Botton, G.

    2011-01-01

    Research efforts on materials selection and development in support of the design of supercritical water-cooled reactors (SCWRs) have produced a considerable amount of data on corrosion, creep and other related properties. Summaries of the data on corrosion [1] and stress corrosion cracking [2] have recently been produced. As research on the SCWR advances, gaps and limitations in the published data are being identified. In terms of corrosion properties, these gaps can be seen in several areas, including: 1) the test environment, 2) the physical and chemical severity of the tests conducted as compared with likely reactor service/operating conditions, and 3) the test methods used. While some of these gaps can be filled readily using existing facilities, others require the availability of advanced test facilities for specific tests and assessments. In this paper, highlights of the new materials research facilities jointly established in Hamilton by CANMET Materials Technology Laboratory and McMaster University are presented. (author)

  6. Ethical considerations of research policy for personal genome analysis: the approach of the Genome Science Project in Japan.

    Science.gov (United States)

    Minari, Jusaku; Shirai, Tetsuya; Kato, Kazuto

    2014-12-01

    As evidenced by high-throughput sequencers, genomic technologies have recently undergone radical advances. These technologies enable comprehensive sequencing of personal genomes considerably more efficiently and less expensively than heretofore. These developments present a challenge to the conventional framework of biomedical ethics; under these changing circumstances, each research project has to develop a pragmatic research policy. Based on the experience with a new large-scale project-the Genome Science Project-this article presents a novel approach to conducting a specific policy for personal genome research in the Japanese context. In creating an original informed-consent form template for the project, we present a two-tiered process: making the draft of the template following an analysis of national and international policies; refining the draft template in conjunction with genome project researchers for practical application. Through practical use of the template, we have gained valuable experience in addressing challenges in the ethical review process, such as the importance of sharing details of the latest developments in genomics with members of research ethics committees. We discuss certain limitations of the conventional concept of informed consent and its governance system and suggest the potential of an alternative process using information technology.

  7. 76 FR 66076 - National Human Genome Research Institute; Notice of Closed Meeting

    Science.gov (United States)

    2011-10-25

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Human Genome... Call). Contact Person: Camilla E. Day, PhD, Scientific Review Officer, CIDR, National Human Genome... Assistance Program Nos. 93.172, Human Genome Research, National Institutes of Health, HHS) Dated: October 19...

  8. 77 FR 64816 - National Human Genome Research Institute; Notice of Meeting

    Science.gov (United States)

    2012-10-23

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Human Genome..., National Human Genome Research Institute. The meeting will be open to the public as indicated below, with... invasion of personal privacy. Name of Committee: Board of Scientific Counselors, National Human Genome...

  9. 76 FR 65204 - National Human Genome Research Institute; Notice of Meeting

    Science.gov (United States)

    2011-10-20

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Human Genome..., National Human Genome Research Institute. The meeting will be open to the public as indicated below, with... invasion of personal privacy. Name of Committee: Board of Scientific Counselors, National Human Genome...

  10. 78 FR 61851 - National Human Genome Research Institute; Notice of Closed Meeting

    Science.gov (United States)

    2013-10-04

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Human Genome... unwarranted invasion of personal privacy. Name of Committee: National Human Genome Research Institute Special... a.m. to 4:00 p.m. Agenda: To review and evaluate grant applications. Place: National Human Genome...

  11. 75 FR 80509 - National Human Genome Research Institute; Notice of Closed Meeting

    Science.gov (United States)

    2010-12-22

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Human Genome... Call). Contact Person: Camilla E. Day, PhD, Scientific Review Officer, CIDR, National Human Genome... Assistance Program Nos. 93.172, Human Genome Research, National Institutes of Health, HHS) Dated: December 16...

  12. 76 FR 28056 - National Human Genome Research Institute; Notice of Closed Meetings

    Science.gov (United States)

    2011-05-13

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Human Genome... clearly unwarranted invasion of personal privacy. Name of Committee: National Human Genome Research... D. Nakamura, PhD, Scientific Review Officer, Office of Scientific Review, National Human Genome...

  13. 75 FR 52538 - National Human Genome Research Institute; Notice of Closed Meeting

    Science.gov (United States)

    2010-08-26

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Human Genome... unwarranted invasion of personal privacy. Name of Committee: National Human Genome Research Institute Special... Person: Ken D. Nakamura, PhD, Scientific Review Officer, Scientific Review Branch, National Human Genome...

  14. 76 FR 35223 - National Human Genome Research Institute; Notice of Closed Meeting

    Science.gov (United States)

    2011-06-16

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Human Genome... unwarranted invasion of personal privacy. Name of Committee: National Human Genome Research Institute Special... Person: Rudy O. Pozzatti, PhD, Scientific Review Officer, Scientific Review Branch, National Human Genome...

  15. 75 FR 60467 - National Human Genome Research Institute; Notice of Meeting

    Science.gov (United States)

    2010-09-30

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Human Genome..., National Human Genome Research Institute. The meeting will be open to the public as indicated below, with... invasion of personal privacy. Name of Committee: Board of Scientific Counselors, National Human Genome...

  16. Genomics:GTL Bioenergy Research Centers White Paper

    Energy Technology Data Exchange (ETDEWEB)

    Mansfield, Betty Kay [ORNL; Alton, Anita Jean [ORNL; Andrews, Shirley H [ORNL; Bownas, Jennifer Lynn [ORNL; Casey, Denise [ORNL; Martin, Sheryl A [ORNL; Mills, Marissa [ORNL; Nylander, Kim [ORNL; Wyrick, Judy M [ORNL; Drell, Dr. Daniel [Office of Science, Department of Energy; Weatherwax, Sharlene [U.S. Department of Energy; Carruthers, Julie [U.S. Department of Energy

    2006-08-01

    In his Advanced Energy Initiative announced in January 2006, President George W. Bush committed the nation to new efforts to develop alternative sources of energy to replace imported oil and fossil fuels. Developing cost-effective and energy-efficient methods of producing renewable alternative fuels such as cellulosic ethanol from biomass and solar-derived biofuels will require transformational breakthroughs in science and technology. Incremental improvements in current bioenergy production methods will not suffice. The Genomics:GTL Bioenergy Research Centers will be dedicated to fundamental research on microbe and plant systems with the goal of developing knowledge that will advance biotechnology-based strategies for biofuels production. The aim is to spur substantial progress toward cost-effective production of biologically based renewable energy sources. This document describes the rationale for the establishment of the centers and their objectives in light of the U.S. Department of Energy's mission and goals. Developing energy-efficient and cost-effective methods of producing alternative fuels such as cellulosic ethanol from biomass will require transformational breakthroughs in science and technology. Incremental improvements in current bioenergy-production methods will not suffice. The focus on microbes (for cellular mechanisms) and plants (for source biomass) fundamentally exploits capabilities well known to exist in the microbial world. Thus 'proof of concept' is not required, but considerable basic research into these capabilities remains an urgent priority. Several developments have converged in recent years to suggest that systems biology research into microbes and plants promises solutions that will overcome critical roadblocks on the path to cost-effective, large-scale production of cellulosic ethanol and other renewable energy from biomass. The ability to rapidly sequence the DNA of any organism is a critical part of these new

  17. 32 CFR 22.310 - Statutes concerning certain research, development, and facilities construction grants.

    Science.gov (United States)

    2010-07-01

    ... higher education for the performance of research and development or for the construction of research or... for research and development, or of a grant for the construction of research or other facilities... research and development or for the construction of research or other facilities are to be awarded to...

  18. Anti- and Hypermatter Research at the Facility for Antiproton and Ion Research FAIR

    International Nuclear Information System (INIS)

    Steinheimer, J; Xu, Z; Gudima, K; Botvina, A; Mishustin, I; Bleicher, M; Stöcker, H

    2012-01-01

    Within the next six years, the Facility for Antiproton and Ion Research (FAIR) is built adjacent to the existing accelerator complex of the GSI Helmholtz Center for Heavy Ion Research at Darmstadt, Germany. Thus, the current research goals and the technical possibilities are substantially expanded. With its worldwide unique accelerator and experimental facilities, FAIR will provide a wide range of unprecedented fore-front research in the fields of hadron, nuclear, atomic, plasma physics and applied sciences which are summarized in this article. As an example this article presents research efforts on strangeness at FAIR using heavy ion collisions, exotic nuclei from fragmentation and antiprotons to tackle various topics in this area. In particular, the creation of hypernuclei and antimatter is investigated.

  19. Neutron beam facilities at the Australian Replacement Research Reactor

    International Nuclear Information System (INIS)

    Kennedy, Shane; Robinson, Robert; Hunter, Brett

    2001-01-01

    Australia is building a research reactor to replace the HIFAR reactor at Lucas Heights by the end of 2005. Like HIFAR, the Replacement Research Reactor will be multipurpose with capabilities for both neutron beam research and radioisotope production. It will be a pool-type reactor with thermal neutron flux (unperturbed) of 4 x 10 14 n/cm 2 /sec and a liquid D 2 cold neutron source. Cold and thermal neutron beams for neutron beam research will be provided at the reactor face and in a large neutron guide hall. Supermirror neutron guides will transport cold and thermal neutrons to the guide hall. The reactor and the associated infrastructure, with the exception of the neutron beam instruments, is to be built by INVAP S.E. under contract. The neutron beam instruments will be developed by ANSTO, in consultation with the Australian user community. This status report includes a review the planned scientific capabilities, a description of the facility and a summary of progress to date. (author)

  20. Atmospheric Radiation Measurement Climate Research Facility (ACRF) Annual Report 2008

    Energy Technology Data Exchange (ETDEWEB)

    LR Roeder

    2008-12-01

    The Importance of Clouds and Radiation for Climate Change: The Earth’s surface temperature is determined by the balance between incoming solar radiation and thermal (or infrared) radiation emitted by the Earth back to space. Changes in atmospheric composition, including greenhouse gases, clouds, and aerosols, can alter this balance and produce significant climate change. Global climate models (GCMs) are the primary tool for quantifying future climate change; however, there remain significant uncertainties in the GCM treatment of clouds, aerosol, and their effects on the Earth’s energy balance. In 1989, the U.S. Department of Energy (DOE) Office of Science created the Atmospheric Radiation Measurement (ARM) Program to address scientific uncertainties related to global climate change, with a specific focus on the crucial role of clouds and their influence on the transfer of radiation in the atmosphere. To reduce these scientific uncertainties, the ARM Program uses a unique twopronged approach: • The ARM Climate Research Facility, a scientific user facility for obtaining long-term measurements of radiative fluxes, cloud and aerosol properties, and related atmospheric characteristics in diverse climate regimes; and • The ARM Science Program, focused on the analysis of ACRF and other data to address climate science issues associated with clouds, aerosols, and radiation, and to improve GCMs. This report provides an overview of each of these components and a sample of achievements for each in fiscal year (FY) 2008.

  1. Personal neutron dosimetry at a research reactor facility

    International Nuclear Information System (INIS)

    Kamenopoulou, V.; Carinou, E.; Stamatelatos, I.E.

    2001-01-01

    Individual neutron monitoring presents several difficulties due to the differences in energy response of the dosemeters. In the present study, an individual dosemeter (TLD) calibration approach is attempted for the personnel of a research reactor facility. The neutron energy response function of the dosemeter was derived using the MCNP code. The results were verified by measurements to three different neutron spectra and were found to be in good agreement. Three different calibration curves were defined for thermal, intermediate and fast neutrons. At the different working positions around the reactor, neutron spectra were defined using the Monte Carlo technique and ambient dose rate measurements were performed. An estimation of the neutrons energy is provided by the ratio of the different TLD pellets of each dosemeter in combination with the information concerning the worker's position; then the dose equivalent is deduced according to the appropriate calibration curve. (author)

  2. The NIST NBSR and Cold Neutron Research Facility

    Energy Technology Data Exchange (ETDEWEB)

    Rush, J.J. [National Inst. of Standards and Technology, Guthersburg, MD (United States)

    1994-12-31

    The 20 MW Neutron Beam Split-Core Reactor (NBSR) has nine radial thermal beam tubes, and a large, highly accessible (35cm) cold source serving an extensive network of eight guide tubes. In operation or under construction are twenty-five neutron beam instruments (20 for neutron scattering) and about a dozen other facilities for neutron trace analysis, dosimetry and irradiation. The 6 x 15cm cold neutron guides are coated with {sup 58}Ni, and the last three being installed this fall are coated top and bottom with supermirrors for further increases in intensity. The new semi-spherical liquid hydrogen source will be described, along with the eight scattering instruments (reflectometry, SANS and high-resolution spectroscopy) which have, or will have, an extensive use in biological research. These instruments will likely provide the best overall capability in the U.S. for the next decade for a number of applications in biomolecular structure and dynamics.

  3. ARM Climate Research Facility Quarterly Value-Added Product Report

    Energy Technology Data Exchange (ETDEWEB)

    Sivaraman, C. [DOE ARM Climate Research Facility, Washington, DC (United States)

    2016-10-01

    The purpose of this report is to provide a concise status update for Value-Added Products (VAPs) implemented by the Atmospheric Radiation Measurement (ARM) Climate Research Facility. The report is divided into the following sections: (1) new VAPs for which development has begun; (2) progress on existing VAPs; (3) future VAPs that have been recently approved; (4) other work that leads to a VAP; (5) top requested VAPs from the ARM Data Archive; and (6) a summary of VAP and data releases to production and evaluation. New information is highlighted in blue text. New information about processed data by the developer is highlighted in red text. The upcoming milestones and dates are highlighted in green.

  4. Attitudes of stakeholders in psychiatry towards the inclusion of children in genomic research

    DEFF Research Database (Denmark)

    Sundby, Anna; Boolsen, Merete Watt; Burgdorf, Kristoffer Sølvsten

    2018-01-01

    BACKGROUND: Genomic sequencing of children in research raises complex ethical issues. This study aims to gain more knowledge on the attitudes towards the inclusion of children as research subjects in genomic research and towards the disclosure of pertinent and incidental findings to the parents a...

  5. Irradiation facilities for materials research: IFMIF and small scale installations

    International Nuclear Information System (INIS)

    Perlado, J. M.; Victoria, M.

    2007-01-01

    The research of advance materials in nuclear fields such as new fission reactors (Generation-IV), Accelerator Driven Systems for Transmutation of Radioactive Wastes and Nuclear Fusion, is becoming very much common in the types of low activation and radiation resistant Materials. Ferritic-Martensitic Steels (based in 9-12 Cr) with or without Oxide Dispersion Techniques (Ytria Nanoparticles), Composites materials are becoming the new generation to answer requirements of high temperature, high radiation resistance of structural materials. Special dedication is appearing in general research programmes to this area of Materials. The understanding of their final performance needs a wider knowledge of the mechanisms of radiation damage in these materials from the atomistic scale to the macroscopic responses. New extensive campaigns are being funded to irradiate from simple elements to model alloys and finally the complex materials themselves. That sequence and its state of art will be presented One clear technique for that understanding is the Multi scale Modelling which includes simulation techniques from quantum mechanics, molecular dynamics, defects diffusion, mesoscopic modelling and finally the macroscopic constitutive relations for macroscopic analysis. However, in each one of these steps is necessary a systematic and well established program of experiments that combines the irradiation and the very detailed analysis with techniques such as Transmission Electron Microscope, Positron Annihilation, SIMS, Atom Probe, Nanoindebntation. A key aspect that wants to be presented in this work is the state of art and discussion of Irradiation Facilities for Materials studies. Those facilities goes from ion implantation sources, small accelerator, Experimental Reactors such High Flux Reactor, sophisticated Triple Beams Sources as JANNUS in France to generate at the same time displacements-hydrogen-helium, and projected very large neutron installation such as IFMIF. The role to

  6. Recent advances in Echinococcus genomics and stem cell research.

    Science.gov (United States)

    Koziol, U; Brehm, K

    2015-10-30

    Alveolar and cystic echinococcosis, caused by the metacestode larval stages of the tapeworms Echinococcus multilocularis and Echinococcus granulosus, respectively, are life-threatening diseases and very difficult to treat. The introduction of benzimidazole-based chemotherapy, which targets parasite β-tubulin, has significantly improved the life-span and prognosis of echinococcosis patients. However, benzimidazoles show only parasitostatic activity, are associated with serious adverse side effects and have to be administered for very long time periods, underlining the need for new drugs. Very recently, the nuclear genomes of E. multilocularis and E. granulosus have been characterised, revealing a plethora of data for gaining a deeper understanding of host-parasite interaction, parasite development and parasite evolution. Combined with extensive transcriptome analyses of Echinococcus life cycle stages these investigations also yielded novel clues for targeted drug design. Recent years also witnessed significant advancements in the molecular and cellular characterisation of the Echinococcus 'germinative cell' population, which forms a unique stem cell system that differs from stem cells of other organisms in the expression of several genes associated with the maintenance of pluripotency. As the only parasite cell type capable of undergoing mitosis, the germinative cells are central to all developmental transitions of Echinococcus within the host and to parasite expansion via asexual proliferation. In the present article, we will briefly introduce and discuss recent advances in Echinococcus genomics and stem cell research in the context of drug design and development. Interestingly, it turns out that benzimidazoles seem to have very limited effects on Echinococcus germinative cells, which could explain the high recurrence rates observed after chemotherapeutic treatment of echinococcosis patients. This clearly indicates that future efforts into the development of

  7. Trends in animal use at US research facilities.

    Science.gov (United States)

    Goodman, Justin; Chandna, Alka; Roe, Katherine

    2015-07-01

    Minimising the use of animals in experiments is universally recognised by scientists, governments and advocates as an ethical cornerstone of research. Yet, despite growing public opposition to animal experimentation, mounting evidence that animal studies often do not translate to humans, and the development of new research technologies, a number of countries have reported increased animal use in recent years. In the USA--one of the world's largest users of animals in experiments--a lack of published data on the species most commonly used in laboratories (eg, mice, rats and fish) has prevented such assessments. The current study aimed to fill this gap by analysing the use of all vertebrate animals by the top institutional recipients of National Institutes of Health research funds over a 15-year period. These data show a statistically significant 72.7% increase in the use of animals at these US facilities during this time period-driven primarily by increases in the use of mice. Our results highlight a need for greater efforts to reduce animal use. We discuss technical, institutional, sociological and psychological explanations for this trend. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

  8. Radiation protection planning for decommissioning of research reactor facilities

    International Nuclear Information System (INIS)

    Jackson, Roger; Harman, Neil; Craig, David; Fecitt, Lorna; Lobach, Yuri; Gorlinskij, Juri; Kolyadin, Vyacheslav; Pavlenko, Vytali

    2008-01-01

    The MR reactor at the Russian Research Centre Kurchatov Institute (RRCKI), Moscow was a 50 MW multipurpose material testing and research reactor equipped with nine experimental loop facilities to test prototype fuel for various nuclear power reactors being developed. The reactor was shut down in 1993 and de-fuelled. The experimental loops are located in basement rooms around the reactor. The nature of the research into the characteristics of fuel design and coolant chemistry resulted in fission products and activation products in the test loop equipment. Decommissioning of the loops therefore presents a number of challenges. In addition the city of Moscow has expanded such that the RRC KI is now surrounded by housing which had to be taken into account in the radiological protection planning. This paper describes the techniques proposed to undertake the dismantling operations in order to minimise the radiation exposure to workers and members of the public. Estimates have been made of the worker doses which could be incurred during the dismantling process and the environmental impacts which could occur. These are demonstrated to be as low as reasonably achievable. The work was funded by the UK Department of Business Enterprise and Regulatory Reform (DBERR) (formerly the Department of Trade and Industry) under the Nuclear Safety Programme (NSP) set up to address nuclear safety issues in the Former Soviet Union. (author)

  9. Jordan Research and Training Reactor (JRTR) Utilization Facilities

    International Nuclear Information System (INIS)

    Xoubi, N.

    2013-01-01

    Jordan Research and Training Reactor (JRTR) is a 5 MW light water open pool multipurpose reactor that serves as the focal point for Jordan National Nuclear Centre, and is designed to be utilized in three main areas: Education and training, nuclear research, and radioisotopes production and other commercial and industrial services. The reactor core is composed of 18 fuel assemblies, MTR plate type 19.75% enriched uranium silicide (U 3 Si 2 ) in aluminium matrix, and is reflected on all sides by beryllium and graphite. The reactor power is upgradable to 10 MW with a maximum thermal flux of 1.45×10 14 cm -2 s -1 , and is controlled by a Hafnium control absorber rod and B 4 C shutdown rod. The reactor is designed to include laboratories and classrooms that will support the establishment of a nuclear reactor school for educating and training students in disciplines like nuclear engineering, reactor physics, radiochemistry, nuclear technology, radiation protection, and other related scientific fields where classroom instruction and laboratory experiments will be related in a very practical and realistic manner to the actual operation of the reactor. JRTR is designed to support advanced nuclear research as well as commercial and industrial services, which can be preformed utilizing any of its 35 experimental facilities. (author)

  10. A Comparative Analysis of Indigenous Research Guidelines to Inform Genomic Research in Indigenous Communities

    Directory of Open Access Journals (Sweden)

    Jay Maddock

    2012-05-01

    Full Text Available BACKGROUND: Genetic research has potential benefits for improving health, such as identifying molecular characteristics of a disease, understanding disease prevalence and treatment, and developing treatments tailored to patients based on individual genetic characteristics of their disease. Indigenous people are often targeted for genetic research because genes are easier to study in communities that practice endogamy. Therefore, populations perceived to be more homogenous, such as Indigenous peoples, are ideal for genetic studies. While Indigenous communities remain the focal point of many genomic studies, some result in harm and unethical practice. Unfortunately, the harms of poorly formulated and unethical research involving Indigenous people have created barriers to participation that prevent critical and lifesaving research. These harms have led a number of Indigenous communities to develop guidelines for engaging with researchers to assist in safely bridging the gap between genetic research and Indigenous peoples.SPECIFIC AIMS: The specific aims of this study were: (1 to conduct an international review and comparison of Indigenous research guidelines that highlight topics regarding genetics and use of biological samples and identify commonalities and differences among ethical principles of concern to Indigenous peoples; and (2 develop policy recommendations for Indigenous populations interested in creating formal policies around the use of genetic information and protection of biological samples using data from specific aim 1.METHODS: A comparative analysis was performed to identify best research practices and recommendations for Indigenous groups from four countries: Canada, New Zealand, Australia, and the United States. The analysis examined commonalities in political relationships, which support self-determination among these Indigenous communities to control their data. Current international Indigenous guidelines were analyzed to review

  11. Anomalous radon concentration in a nuclear research facility

    International Nuclear Information System (INIS)

    Balcazar, M.; Pena, P.

    2014-08-01

    Radon monitoring in more than 60 selected points were part of surveillance radiation activities in the nuclear center of Mexico; three major facilities were inspected, the TRIGA Mark III research reactor, the Tandem Van de Graaff Accelerator and the Pelletron electron Accelerator. During a major maintenance activities in the research reactor, the air extraction system was not functioning for more than a month causing of a radon build up exhaled from the massive concrete of the building, reaching concentrations in some places up to 2.1 kb m -3 . The irradiation room at the Tandem Accelerator presented high radon concentrations up to nearly 5 kb m -3 , manly in the trenches were pipes and electric wires are located, the radon source was identified as originated from small caves under the floor. Low radon concentrations were found inside a similar building where a Pelletron accelerator is located. The reasons for the abnormal radon concentrations and the mitigation actions to remove any risk for the worker are discussed in detail in this paper. (author)

  12. Tritium research and technology facilities at the JRC-Ispra

    International Nuclear Information System (INIS)

    Dworschak, H.; Mannone, F.; Perujo, A.; Pierini, G.; Reiter, F.; Vassallo, G.; Viola, A.; Camposilvan, J.; Douglas, K.; Grassi, G.; Lolli Ceroni, P.; Simonetta, A.; Spelta, B.

    1990-01-01

    A set of experiments which are of prominent interest for the development of nuclear fusion technology in Europe are planned by the JRC-Ispra for the near future, in the frame of experimental activities to be performed in ETHEL, the European Tritium Handling Experimental Laboratory under construction at the Ispra site. These experiments already included for the most part as JRC-Task Action Sheets in the 1989-1991 European Technology Programme Actions will initiate in ETHEL on a fully active laboratory scale starting mid-1991. They will concern the following research areas: Recycling of tritium from first wall materials; Tritium recovery from water cooled Pb-17Li blankets; Detritiation of ventilation atmospheres; Plasma exhaust processing; Tritiazed waste management. In view of fully active tritium experiments in ETHEL and to obtain information of the basic processes involved, since 1985 preparatory experimental studies are being performed at the JRC-Ispra laboratories using hydrogen and deuterium. Furthermore, always with regard to ETHEL experiments, particular attention is given to possible technical and managerial problems which potentially may arise in this context. To identify at an early stage such problems a questionnaire has been developed and distributed to researchers in conjunction with an ETHEL information packet. The questionnaire demands information regarding the scope, design and operation of the intended experiment as well as planning and required support to be supplied by ETHEL. A brief description of experimental preparatory studies and future tritium handling experiments in ETHEL as well of the ETHEL facility is here presented. (orig.)

  13. Anomalous radon concentration in a nuclear research facility

    Energy Technology Data Exchange (ETDEWEB)

    Balcazar, M.; Pena, P., E-mail: miguel.balcazar@inin.gob.mx [ININ, Carretera Mexico-Toluca s/n, 52750 Ocoyoacac, Estado de Mexico (Mexico)

    2014-08-15

    Radon monitoring in more than 60 selected points were part of surveillance radiation activities in the nuclear center of Mexico; three major facilities were inspected, the TRIGA Mark III research reactor, the Tandem Van de Graaff Accelerator and the Pelletron electron Accelerator. During a major maintenance activities in the research reactor, the air extraction system was not functioning for more than a month causing of a radon build up exhaled from the massive concrete of the building, reaching concentrations in some places up to 2.1 kb m{sup -3}. The irradiation room at the Tandem Accelerator presented high radon concentrations up to nearly 5 kb m{sup -3}, manly in the trenches were pipes and electric wires are located, the radon source was identified as originated from small caves under the floor. Low radon concentrations were found inside a similar building where a Pelletron accelerator is located. The reasons for the abnormal radon concentrations and the mitigation actions to remove any risk for the worker are discussed in detail in this paper. (author)

  14. Using Microbial Genome Annotation as a Foundation for Collaborative Student Research

    Science.gov (United States)

    Reed, Kelynne E.; Richardson, John M.

    2013-01-01

    We used the Integrated Microbial Genomes Annotation Collaboration Toolkit as a framework to incorporate microbial genomics research into a microbiology and biochemistry course in a way that promoted student learning of bioinformatics and research skills and emphasized teamwork and collaboration as evidenced through multiple assessment mechanisms.…

  15. The potential of metabolomics for Leishmania research in the post-genomics era

    NARCIS (Netherlands)

    Scheltema, Richard A.; Decuypere, Saskia; T'Kindt, Ruben; Dujardin, Jean-Claude; Coombs, Graham H.; Breitling, Rainer; T’Kindt, Ruben

    The post-genomics era has provided researchers with access to a new generation of tools for the global characterization and understanding of pathogen diversity. This review provides a critical summary of published Leishmania post-genomic research efforts to date, and discusses the potential impact

  16. 77 FR 67385 - National Human Genome Research Institute; Amended Notice of Meeting

    Science.gov (United States)

    2012-11-09

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Human Genome Research Institute; Amended Notice of Meeting Notice is hereby given of a change in the meeting of the National Human Genome Research Institute Special Emphasis Panel, October 29, 2012, 8:00 a.m. to October 30...

  17. 78 FR 65342 - National Human Genome Research Institute; Amended Notice of Meeting

    Science.gov (United States)

    2013-10-31

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Human Genome Research Institute; Amended Notice of Meeting Notice is hereby given of a change in the meeting of the National Human Genome Research Institute Special Emphasis Panel, October 17, 2013, 08:00 a.m. to October 17...

  18. 76 FR 65738 - National Human Genome Research Institute; Amended Notice of Meeting

    Science.gov (United States)

    2011-10-24

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Human Genome Research Institute; Amended Notice of Meeting Notice is hereby given of a change in the meeting of the National Human Genome Research Institute Special Emphasis Panel, November 29, 2011, 8 a.m. to November 29...

  19. 77 FR 55853 - National Human Genome Research Institute; Amended Notice of Meeting

    Science.gov (United States)

    2012-09-11

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Human Genome Research Institute; Amended Notice of Meeting Notice is hereby given of a change in the meeting of the National Advisory Council for Human Genome Research, September 10, 2012, 8:30 a.m. to September 11, 2012, 5...

  20. 77 FR 27471 - National Human Genome Research Institute Amended Notice of Meeting

    Science.gov (United States)

    2012-05-10

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Human Genome Research Institute Amended Notice of Meeting Notice is hereby given of a change in the meeting of the National Advisory Council for Human Genome Research, May 21, 2012, 8:30 a.m. to May 22, 2012, 5:00 p.m...

  1. 76 FR 71581 - National Human Genome Research Institute; Amended Notice of Meeting

    Science.gov (United States)

    2011-11-18

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Human Genome Research Institute; Amended Notice of Meeting Notice is hereby given of a change in the meeting of the National Human Genome Research Institute Special Emphasis Panel, November 22, 2011, 12 p.m. to November 22...

  2. A new apparatus at hyper irradiation research facility at the Atomic Research Center, University of Tokyo

    Energy Technology Data Exchange (ETDEWEB)

    Shibata, Hiromi; Iwai, Takeo; Narui, Makoto; Omata, Takao [Tokyo Univ. (Japan). Research Center for Nuclear Science and Technology

    1996-12-01

    In the hyper irradiation research facility at the Atomic Research Center, the University of Tokyo, following apparatuses were newly installed for accelerator relating apparatus on 1995 fiscal year; (1) Hyper ion microbeam analysis apparatus, (2) Fourier conversion infrared microscopy, (3) Pico second two-dimensional fluorescence measuring apparatus, (4) Femto second wave-length reversible pulse laser radiation apparatus, and others. In addition to double irradiation, pulse beam irradiation experiment and so forth characteristic in conventional hyper irradiation research apparatus, upgrading of material irradiation experiments using these new apparatuses are intended. (G.K.)

  3. A new apparatus at hyper irradiation research facility at the Atomic Research Center, University of Tokyo

    International Nuclear Information System (INIS)

    Shibata, Hiromi; Iwai, Takeo; Narui, Makoto; Omata, Takao

    1996-01-01

    In the hyper irradiation research facility at the Atomic Research Center, the University of Tokyo, following apparatuses were newly installed for accelerator relating apparatus on 1995 fiscal year; 1) Hyper ion microbeam analysis apparatus, 2) Fourier conversion infrared microscopy, 3) Pico second two-dimensional fluorescence measuring apparatus, 4) Femto second wave-length reversible pulse laser radiation apparatus, and others. In addition to double irradiation, pulse beam irradiation experiment and so forth characteristic in conventional hyper irradiation research apparatus, upgrading of material irradiation experiments using these new apparatuses are intended. (G.K.)

  4. Orange County Government Solar Demonstration and Research Facility

    Energy Technology Data Exchange (ETDEWEB)

    Parker, Renee [Orange County Florida, Orlando, Florida (United States); Cunniff, Lori [Orange County Florida, Orlando, Florida (United States)

    2015-05-12

    Orange County Florida completed the construction of a 20 kilowatt Solar Demonstration and Research Facility in March 2015. The system was constructed at the Orange County/University of Florida Cooperative Extension Center whose electric service address is 6021 South Conway Road, Orlando, Florida 32802. The Solar Demonstration and Research Facility is comprised of 72 polycrystalline photovoltaic modules and 3 inverters which convert direct current from the solar panels to alternating current electricity. Each module produces 270 watts of direct current power, for a total canopy production of just under 20,000 watts. The solar modules were installed with a fixed tilt of 5 degrees and face south, toward the equator to maximize the amount of sunlight captures. Each year, the electricity generated by the solar array will help eliminate 20 metric tons of carbon dioxide emissions as well as provide covered parking for staff and visitors vehicles. The solar array is expected to generate 27,000 kilowatt hours of electricity annually equating to an estimated $266 savings in the monthly electric bill, or $3,180 annually for the Orange County/University of Florida Cooperative Extension Center. In addition to reducing the electric bill for the Extension Center, Orange County’s solar array also takes advantage of a rebate incentive offered by the local utility, Orlando Utility Commission, which provided a meter that measures the amount of power produced by the solar array. The local utility company’s Solar Photovoltaic Production Incentive will pay Orange County $0.05 per kilowatt hour for the power that is produced by the solar array. This incentive is provided in addition to Net Metering benefits, which is an effort to promote the use of clean, renewable energy on the electric grid. The Photovoltaic Solar Demonstration and Research Facility also serves an educational tool to the public; the solar array is tied directly into a data logger that provides real time power

  5. Report of the research results with JAERI's facilities in fiscal 1975

    International Nuclear Information System (INIS)

    1976-07-01

    Results of the research works by educational institutions using facilities of the Japan Atomic Energy Research Institute in fiscal 1975 are reported in individual summaries. Facilities utilized are research reactors, Co-60 irradiation facilities, hot laboratory, Linac and electron accelerators. Fields of research are the following: nuclear physics, radiation damage/solid-state physics, positron annihilation, activation analysis/nuclear chemistry, hot atom chemistry, irradiation effects, biology, and neutron diffraction; and, cooperative works to JAERI. (Mori, K.)

  6. A neutron tomography facility at a low power research reactor

    CERN Document Server

    Körner, S; Von Tobel, P; Rauch, H

    2001-01-01

    Neutron radiography (NR) provides a very efficient tool in the field of non-destructive testing as well as for many applications in fundamental research. A neutron beam penetrating a specimen is attenuated by the sample material and detected by a two-dimensional (2D) imaging device. The image contains information about materials and structure inside the sample because neutrons are attenuated according to the basic law of radiation attenuation. Contrary to X-rays, neutrons can be attenuated by some light materials, as for example, hydrogen and boron, but penetrate many heavy materials. Therefore, NR can yield important information not obtainable by more traditional methods. Nevertheless, there are many aspects of structure, both quantitative and qualitative, that are not accessible from 2D transmission images. Hence, there is an interest in three-dimensional neutron imaging. At the 250 kW TRIGA Mark II reactor of the Atominstitut in Austria a neutron tomography facility has been installed. The neutron flux at ...

  7. Joint Actinide Shock Physics Experimental Research (JASPER) Facility Update

    International Nuclear Information System (INIS)

    Conrad, C. H.; Miller, J.; Cowan, M.; Martinez, M.; Whitcomb, B.

    2003-01-01

    The JASPER Facility utilizes a Two-Stage Light Gas Gun to conduct equation-of-state(EOS) experiments on plutonium and other special nuclear materials. The overall facility will be discussed with emphasis on the Two-Stage Light Gas Gun characteristics and control interfaces and containment. The containment systems that were developed for this project will be presented

  8. Profiles of facilities used for FBR research and testing

    International Nuclear Information System (INIS)

    1976-12-01

    This document contains a concise up-to date of supporting ''Liquid Metal Fast Breeder'' facilities submitted by countries (Federal Republic of Germany, Italy, France, Belgium, Netherlands, UK, USA, USSR and Japan) and international organizations. It has the purpose of providing an over-view of the facilities currently used or under construction and of the type of experiments that can be conducted therein

  9. Charger 1: A New Facility for Z-Pinch Research

    Science.gov (United States)

    Taylor, Brian; Cassibry, Jason; Cortez, Ross; Doughty, Glen; Adams, Robert; DeCicco, Anthony

    2017-01-01

    Charger 1 is a multipurpose pulsed power laboratory located on Redstone Arsenal, with a focus on fusion propulsion relevant experiments involving testing z-pinch diodes, pulsed magnetic nozzle and other related physics experiments. UAH and its team of pulsed power researchers are investigating ways to increase and optimize fusion production from Charger 1. Currently the team has reached high-power testing. Due to the unique safety issues related to high power operations the UAH/MSFC team has slowed repair efforts to develop safety and operations protocols. The facility is expected to be operational by the time DZP 2017 convenes. Charger 1 began life as the Decade Module 2, an experimental prototype built to prove the Decade Quad pinch configuration. The system was donated to UAH by the Defense Threat Reduction Agency (DRTA) in 2012. For the past 5 years a UAH/MSFC/Boeing team has worked to refurbish, assemble and test the system. With completion of high power testing in summer 2017 Charger 1 will become operational for experimentation. Charger 1 utilizes a Marx Bank of 72 100-kV capacitors that are charged in parallel and discharged in series. The Marx output is compressed to a pulse width of approximately 200 ns via a pulse forming network of 32 coaxial stainless steel tubes using water as a dielectric. After pulse compression a set of SF6 switches are triggered, allowing the wave front to propagate through the output line to the load. Charger 1 is capable of storing 572-kJ of energy and time compressing discharge to less than 250 ns discharge time producing a discharge of about 1 TW of discharge with 1 MV and 1 MA peak voltage and current, respectively. This capability will be used to study energy yield scaling and physics from solid density target as applied to advanced propulsion research.

  10. The NASA Lewis Research Center Internal Fluid Mechanics Facility

    Science.gov (United States)

    Porro, A. R.; Hingst, W. R.; Wasserbauer, C. A.; Andrews, T. B.

    1991-01-01

    An experimental facility specifically designed to investigate internal fluid duct flows is described. It is built in a modular fashion so that a variety of internal flow test hardware can be installed in the facility with minimal facility reconfiguration. The facility and test hardware interfaces are discussed along with design constraints of future test hardware. The plenum flow conditioning approach is also detailed. Available instrumentation and data acquisition capabilities are discussed. The incoming flow quality was documented over the current facility operating range. The incoming flow produces well behaved turbulent boundary layers with a uniform core. For the calibration duct used, the boundary layers approached 10 percent of the duct radius. Freestream turbulence levels at the various operating conditions varied from 0.64 to 0.69 percent of the average freestream velocity.

  11. The Soreq Applied Research Accelerator Facility (SARAF): Overview, research programs and future plans

    Science.gov (United States)

    Mardor, Israel; Aviv, Ofer; Avrigeanu, Marilena; Berkovits, Dan; Dahan, Adi; Dickel, Timo; Eliyahu, Ilan; Gai, Moshe; Gavish-Segev, Inbal; Halfon, Shlomi; Hass, Michael; Hirsh, Tsviki; Kaiser, Boaz; Kijel, Daniel; Kreisel, Arik; Mishnayot, Yonatan; Mukul, Ish; Ohayon, Ben; Paul, Michael; Perry, Amichay; Rahangdale, Hitesh; Rodnizki, Jacob; Ron, Guy; Sasson-Zukran, Revital; Shor, Asher; Silverman, Ido; Tessler, Moshe; Vaintraub, Sergey; Weissman, Leo

    2018-05-01

    The Soreq Applied Research Accelerator Facility (SARAF) is under construction in the Soreq Nuclear Research Center at Yavne, Israel. When completed at the beginning of the next decade, SARAF will be a user facility for basic and applied nuclear physics, based on a 40 MeV, 5 mA CW proton/deuteron superconducting linear accelerator. Phase I of SARAF (SARAF-I, 4 MeV, 2 mA CW protons, 5 MeV 1 mA CW deuterons) is already in operation, generating scientific results in several fields of interest. The main ongoing program at SARAF-I is the production of 30 keV neutrons and measurement of Maxwellian Averaged Cross Sections (MACS), important for the astrophysical s-process. The world leading Maxwellian epithermal neutron yield at SARAF-I (5 × 10^{10} epithermal neutrons/s), generated by a novel Liquid-Lithium Target (LiLiT), enables improved precision of known MACSs, and new measurements of low-abundance and radioactive isotopes. Research plans for SARAF-II span several disciplines: precision studies of beyond-Standard-Model effects by trapping light exotic radioisotopes, such as 6He, 8Li and 18, 19, 23Ne, in unprecedented amounts (including meaningful studies already at SARAF-I); extended nuclear astrophysics research with higher energy neutrons, including generation and studies of exotic neutron-rich isotopes relevant to the rapid (r-) process; nuclear structure of exotic isotopes; high energy neutron cross sections for basic nuclear physics and material science research, including neutron induced radiation damage; neutron based imaging and therapy; and novel radiopharmaceuticals development and production. In this paper we present a technical overview of SARAF-I and II, including a description of the accelerator and its irradiation targets; a survey of existing research programs at SARAF-I; and the research potential at the completed facility (SARAF-II).

  12. RESEARCH NOTE Genome-based exome-sequencing analysis ...

    Indian Academy of Sciences (India)

    Navya

    2017-02-22

    Feb 22, 2017 ... Genome-based exome-sequencing analysis identifies GYG1, DIS3L, DDRGK1 genes ... Cardiology Division, Department of Internal Medicine, Severance .... with p values of <0.05 byanalyzing differences in allele distribution.

  13. Brassica ASTRA: an integrated database for Brassica genomic research.

    Science.gov (United States)

    Love, Christopher G; Robinson, Andrew J; Lim, Geraldine A C; Hopkins, Clare J; Batley, Jacqueline; Barker, Gary; Spangenberg, German C; Edwards, David

    2005-01-01

    Brassica ASTRA is a public database for genomic information on Brassica species. The database incorporates expressed sequences with Swiss-Prot and GenBank comparative sequence annotation as well as secondary Gene Ontology (GO) annotation derived from the comparison with Arabidopsis TAIR GO annotations. Simple sequence repeat molecular markers are identified within resident sequences and mapped onto the closely related Arabidopsis genome sequence. Bacterial artificial chromosome (BAC) end sequences derived from the Multinational Brassica Genome Project are also mapped onto the Arabidopsis genome sequence enabling users to identify candidate Brassica BACs corresponding to syntenic regions of Arabidopsis. This information is maintained in a MySQL database with a web interface providing the primary means of interrogation. The database is accessible at http://hornbill.cspp.latrobe.edu.au.

  14. Accelerating research through reagent repositories: the genome editing example.

    Science.gov (United States)

    Joung, J Keith; Voytas, Daniel F; Kamens, Joanne

    2015-11-20

    Keith Joung, Dan Voytas and Joanne Kamens share insights into how the genome editing field was advanced by early access to biological resources and the role in this process that plasmid repositories play.

  15. Sub-Saharan centralized biorepository for genetic and genomic research.

    Science.gov (United States)

    Gasmelseed, Nagla; Elsir, Afrah Awad; Deblasio, Pasquale; Biunno, Ida

    2012-04-15

    Quality-assessed biomedical samples are essential for academia- and industry driven research on human diseases. The etiologies and the molecular genetic factors relevant in African diseases, including both infections and complex degenerative diseases as well as cancer, need to be studied using well annotated and well-preserved biosamples acquired from native African ethnic groups and compare the results with non-African populations and/or with Afro-Americans. However, a number of difficulties negatively impact on the possibility to obtain clinically annotated biological samples in most Sub-Saharan African countries. This is mainly due to major organizational problems, lack of clinical centres that can dedicate resources to research, as well as lack of facilities in which biomaterials can be properly processed and safely stored. Harmonization of biosample acquisition, storage phenotyping schemes and biocomputer infrastructures are the principal objectives of biological resource centers (BRCs). BRCs comprise biobanks of different formats (collection of blood, DNA, tissues, etc., annotated with medical, environmental, life-style and follow up data) a fundamental tool for molecular epidemiological studies aiming to increase excellence and efficacy of biomedical results, drug development and public health. BRCs provide large and highly controlled biomolecular resources necessary to meet the "omics" scientific platforms. Sudan may be a candidate nation to host such infrastructure, in view of its strategic geographical position and the already existing simple biobanking experiences connected with research groups in Central Sudan. Here, we describe the potential role of biobanks in African genetic studies aiming to dissect the eziopathogenesis of complex diseases in relation to environmental and life-style factors. Copyright © 2010 Elsevier B.V. All rights reserved.

  16. Using community-based participatory research principles to develop more understandable recruitment and informed consent documents in genomic research.

    Directory of Open Access Journals (Sweden)

    Harlyn G Skinner

    Full Text Available Heart Healthy Lenoir is a transdisciplinary project aimed at creating long-term, sustainable approaches to reduce cardiovascular disease risk disparities in Lenoir County, North Carolina using a design spanning genomic analysis and clinical intervention. We hypothesized that residents of Lenoir County would be unfamiliar and mistrustful of genomic research, and therefore reluctant to participate; additionally, these feelings would be higher in African-Americans.To test our hypothesis, we conducted qualitative research using community-based participatory research principles to ensure our genomic research strategies addressed the needs, priorities, and concerns of the community. African-American (n = 19 and White (n = 16 adults in Lenoir County participated in four focus groups exploring perceptions about genomics and cardiovascular disease. Demographic surveys were administered and a semi-structured interview guide was used to facilitate discussions. The discussions were digitally recorded, transcribed verbatim, and analyzed in ATLAS.ti.From our analysis, key themes emerged: transparent communication, privacy, participation incentives and barriers, knowledge, and the impact of knowing. African-Americans were more concerned about privacy and community impact compared to Whites, however, African-Americans were still eager to participate in our genomic research project. The results from our formative study were used to improve the informed consent and recruitment processes by: 1 reducing misconceptions of genomic studies; and 2 helping to foster participant understanding and trust with the researchers. Our study demonstrates how community-based participatory research principles can be used to gain deeper insight into the community and increase participation in genomic research studies. Due in part to these efforts 80.3% of eligible African-American participants and 86.9% of eligible White participants enrolled in the Heart Healthy Lenoir Genomics

  17. Ethical issues and best practice in clinically based genomic research: Exeter Stakeholders Meeting Report

    OpenAIRE

    Carrieri, D; Bewshea, C; Walker, G; Ahmad, T; Bowen, W; Hall, A; Kelly, S

    2016-01-01

    Current guidelines on consenting individuals to participate in genomic research are diverse. This creates problems for participants and also for researchers, particularly for clinicians who provide both clinical care and research to their patients. A group of 14 stakeholders met on 7 October 2015 in Exeter to discuss the ethical issues and the best practice arising in clinically based genomic research, with particular emphasis on the issue of returning results to study participants/patients i...

  18. Applied research and service activities at the University of Missouri Research Reactor Facility (MURR)

    International Nuclear Information System (INIS)

    Alger, D.M.

    1987-01-01

    The University Of Missouri operates MURR to provide an intense source of neutron and gamma radiation for research and applications by experimenters from its four campuses and by experimenters from other universities, government and industry. The 10 MW reactor, which has been operating an average of 155 hours per week for the past eight years, produces thermal neutron fluxes up to 6-7x10 14 n/cm 2 -s in the central flux trap and beamport source fluxes of up to 1.2x10 14 n/cm 2 -s. The mission of the reactor facility, to promote research, education and service, is the same as the overall mission of the university and therefore, applied research and service supported by industrial firms have been welcomed. The university recognized after a few years of reactor operation that in order to build utilization, it would be necessary to develop in-house research programs including people, equipment and activity so that potential users could more easily and quickly obtain the results needed. Nine research areas have been developed to create a broadly based program to support the level of activity needed to justify the cost of operating the facility. Applied research and service generate financial support for about one-half of the annual budget. The applied and service programs provide strong motivation for university/industry association in addition to the income generated. (author)

  19. Research study on analysis/use technologies of genome information; Genome joho kaidoku riyo gijutsu no chosa kenkyu

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-03-01

    For wide use of genome information in the industrial field, the required R and D was surveyed from the standpoints of biology and information science. To clarify the present state and issues of the international research on genome analysis, the genome map as well as sequence and function information are first surveyed. The current analysis/use technologies of genome information are analyzed, and the following are summarized: prediction and identification of gene regions in genome sequences, techniques for searching and selecting useful genes, and techniques for predicting the expression of gene functions and the gene-product structure and functions. It is recommended that R and D and data collection/interpretation necessary to clarify inter-gene interactions and information networks should be promoted by integrating Japanese advanced know-how and technologies. As examples of the impact of the research results on industry and society, the present state and future expected effect are summarized for medicines, diagnosis/analysis instruments, chemicals, foods, agriculture, fishery, animal husbandry, electronics, environment and information. 278 refs., 42 figs., 5 tabs.

  20. Medical Applications of Non-Medical Research: Applications Derived from BES-Supported Research and Research at BES Facilities

    Science.gov (United States)

    1998-07-01

    This publication contains stories that illustrate how the Office of Basic Energy Sciences (BES) research and major user facilities have impacted the medical sciences in the selected topical areas of disease diagnosis, treatment (including drug development, radiation therapy, and surgery), understanding, and prevention.

  1. Material accountancy and control practice at a research reactor facility

    International Nuclear Information System (INIS)

    Bouchard, J.; Maurel, J.J.; Tromeur, Y.

    1982-01-01

    This session surveys the regulations, organization, and accountancy practice that compose the French State System of Accountancy and Control. Practical examples are discussed showing how inventories are verified at a critical assembly facility and at a materials testing reactor

  2. Holifield Heavy-Ion Research Facility at Oak Ridge

    International Nuclear Information System (INIS)

    Jones, C.M.

    1977-01-01

    A new heavy-ion accelerator facility is now under construction at the Oak Ridge National Laboratory. A brief description of the scope and schedule of this project is given, and the new large tandem accelerator, which will be a major element of the facility is discussed in some detail. Several studies which have been made or are in progress in Oak Ridge in preparation for operation of the tandem accelerator are briefly described

  3. Joint Actinide Shock Physics Experimental Research (JASPER) Facility Overview

    International Nuclear Information System (INIS)

    Konrad, C.H.; Braddy, R.W.; Martinez, Mark

    2001-01-01

    The JASPER Facility will utilize a Two-Stage Light Gas Gun to conduct equation-of-state (EOS) experiments of plutonium and other special nuclear materials. The overall facility will be discussed with emphasis on the Two-Stage Light Gas Gun characteristics and mission. The primary and secondary containment systems that were developed for this project will be presented. Primary gun diagnostics and timing will also be discussed

  4. CRISPR Genome Engineering for Human Pluripotent Stem Cell Research.

    Science.gov (United States)

    Chaterji, Somali; Ahn, Eun Hyun; Kim, Deok-Ho

    2017-01-01

    The emergence of targeted and efficient genome editing technologies, such as repurposed bacterial programmable nucleases (e.g., CRISPR-Cas systems), has abetted the development of cell engineering approaches. Lessons learned from the development of RNA-interference (RNA-i) therapies can spur the translation of genome editing, such as those enabling the translation of human pluripotent stem cell engineering. In this review, we discuss the opportunities and the challenges of repurposing bacterial nucleases for genome editing, while appreciating their roles, primarily at the epigenomic granularity. First, we discuss the evolution of high-precision, genome editing technologies, highlighting CRISPR-Cas9. They exist in the form of programmable nucleases, engineered with sequence-specific localizing domains, and with the ability to revolutionize human stem cell technologies through precision targeting with greater on-target activities. Next, we highlight the major challenges that need to be met prior to bench-to-bedside translation, often learning from the path-to-clinic of complementary technologies, such as RNA-i. Finally, we suggest potential bioinformatics developments and CRISPR delivery vehicles that can be deployed to circumvent some of the challenges confronting genome editing technologies en route to the clinic.

  5. Research on the Construction Management and Sustainable Development of Large-Scale Scientific Facilities in China

    Science.gov (United States)

    Guiquan, Xi; Lin, Cong; Xuehui, Jin

    2018-05-01

    As an important platform for scientific and technological development, large -scale scientific facilities are the cornerstone of technological innovation and a guarantee for economic and social development. Researching management of large-scale scientific facilities can play a key role in scientific research, sociology and key national strategy. This paper reviews the characteristics of large-scale scientific facilities, and summarizes development status of China's large-scale scientific facilities. At last, the construction, management, operation and evaluation of large-scale scientific facilities is analyzed from the perspective of sustainable development.

  6. Shock Tube and Ballistic Range Facilities at NASA Ames Research Center

    Science.gov (United States)

    Grinstead, Jay H.; Wilder, Michael C.; Reda, Daniel C.; Cornelison, Charles J.; Cruden, Brett A.; Bogdanoff, David W.

    2010-01-01

    The Electric Arc Shock Tube (EAST) facility and the Hypervelocity Free Flight Aerodynamic Facility (HFFAF) at NASA Ames Research Center are described. These facilities have been in operation since the 1960s and have supported many NASA missions and technology development initiatives. The facilities have world-unique capabilities that enable experimental studies of real-gas aerothermal, gas dynamic, and kinetic phenomena of atmospheric entry.

  7. The Radiological Research Accelerator Facility. Progress report, December 1, 1993--November 30, 1994

    International Nuclear Information System (INIS)

    Hall, E.J.; Marino, S.A.

    1994-04-01

    This document begins with a general description of the facility to include historical and up-to-date aspects of design and operation. A user's guide and a review of research using the facility follows. Next the accelerator utilization and operation and the development of the facilities is given. Personnel currently working at the facility are listed. Lastly, recent publications and literature cited are presented

  8. Strategic planning and marketing research for older, inner-city health care facilities: a case study.

    Science.gov (United States)

    Wood, V R; Robertson, K R

    1992-01-01

    Numerous health care facilities, located in downtown metropolitan areas, now find themselves surrounded by a decaying inner-city environment. Consumers may perceive these facilities as "old," and catering to an "urban poor" consumer. These same consumers may, therefore, prefer to patronize more modern facilities located in suburban areas. This paper presents a case study of such a health care facility and how strategic planning and marketing research were conducted in order to identify market opportunities and new strategic directions.

  9. 77 FR 50140 - National Human Genome Research Institute; Notice of Closed Meeting

    Science.gov (United States)

    2012-08-20

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Human Genome..., Human Genome Research, National Institutes of Health, HHS) Dated: August 13, 2012. Anna Snouffer, Deputy..., Bethesda, MD 20892. Contact Person: Camilla E. Day, Ph.D., Scientific Review Officer, CIDR, National Human...

  10. 77 FR 64816 - National Human Genome Research Institute; Notice of Closed Meeting

    Science.gov (United States)

    2012-10-23

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Human Genome..., Human Genome Research, National Institutes of Health, HHS) Dated: October 16, 2012. David Clary, Program... Conference Call). Contact Person: Camilla E. Day, Ph.D., Scientific Review Officer, CIDR, National Human...

  11. 78 FR 11898 - National Human Genome Research Institute; Notice of Closed Meeting

    Science.gov (United States)

    2013-02-20

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Human Genome....172, Human Genome Research, National Institutes of Health, HHS) Dated: February 13, 2013. David Clary... Conference Call). Contact Person: Camilla E. Day, Ph.D., Scientific Review Officer CIDR, National Human...

  12. 78 FR 77477 - National Human Genome Research Institute; Notice of Closed Meeting

    Science.gov (United States)

    2013-12-23

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Human Genome..., Human Genome Research, National Institutes of Health, HHS). Dated: December 17, 2013. David Clary... Conference Call). Contact Person: Camilla E. Day, Ph.D., Scientific Review Officer, CIDR, National Human...

  13. Hardware Development Process for Human Research Facility Applications

    Science.gov (United States)

    Bauer, Liz

    2000-01-01

    The simple goal of the Human Research Facility (HRF) is to conduct human research experiments on the International Space Station (ISS) astronauts during long-duration missions. This is accomplished by providing integration and operation of the necessary hardware and software capabilities. A typical hardware development flow consists of five stages: functional inputs and requirements definition, market research, design life cycle through hardware delivery, crew training, and mission support. The purpose of this presentation is to guide the audience through the early hardware development process: requirement definition through selecting a development path. Specific HRF equipment is used to illustrate the hardware development paths. The source of hardware requirements is the science community and HRF program. The HRF Science Working Group, consisting of SCientists from various medical disciplines, defined a basic set of equipment with functional requirements. This established the performance requirements of the hardware. HRF program requirements focus on making the hardware safe and operational in a space environment. This includes structural, thermal, human factors, and material requirements. Science and HRF program requirements are defined in a hardware requirements document which includes verification methods. Once the hardware is fabricated, requirements are verified by inspection, test, analysis, or demonstration. All data is compiled and reviewed to certify the hardware for flight. Obviously, the basis for all hardware development activities is requirement definition. Full and complete requirement definition is ideal prior to initiating the hardware development. However, this is generally not the case, but the hardware team typically has functional inputs as a guide. The first step is for engineers to conduct market research based on the functional inputs provided by scientists. CommerCially available products are evaluated against the science requirements as

  14. CRISPR/Cas9 for Human Genome Engineering and Disease Research.

    Science.gov (United States)

    Xiong, Xin; Chen, Meng; Lim, Wendell A; Zhao, Dehua; Qi, Lei S

    2016-08-31

    The clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated 9 (Cas9) system, a versatile RNA-guided DNA targeting platform, has been revolutionizing our ability to modify, manipulate, and visualize the human genome, which greatly advances both biological research and therapeutics development. Here, we review the current development of CRISPR/Cas9 technologies for gene editing, transcription regulation, genome imaging, and epigenetic modification. We discuss the broad application of this system to the study of functional genomics, especially genome-wide genetic screening, and to therapeutics development, including establishing disease models, correcting defective genetic mutations, and treating diseases.

  15. What research ethics should learn from genomics and society research: lessons from the ELSI Congress of 2011.

    Science.gov (United States)

    Henderson, Gail E; Juengst, Eric T; King, Nancy M P; Kuczynski, Kristine; Michie, Marsha

    2012-01-01

    Research on the ethical, legal, and social implications (ELSI) of human genomics has devoted significant attention to the research ethics issues that arise from genomic science as it moves through the translational process. Given the prominence of these issues in today's debates over the state of research ethics overall, these studies are well positioned to contribute important data, contextual considerations, and policy arguments to the wider research ethics community's deliberations, and ultimately to develop a research ethics that can help guide biomedicine's future. In this essay, we illustrate this thesis through an analytic summary of the research presented at the 2011 ELSI Congress, an international meeting of genomics and society researchers. We identify three pivotal factors currently shaping genomic research, its clinical translation, and its societal implications: (1) the increasingly blurred boundary between research and treatment; (2) uncertainty--that is, the indefinite, indeterminate, and incomplete nature of much genomic information and the challenges that arise from making meaning and use of it; and (3) the role of negotiations between multiple scientific and non-scientific stakeholders in setting the priorities for and direction of biomedical research, as it is increasingly conducted "in the public square." © 2012 American Society of Law, Medicine & Ethics, Inc.

  16. YALINA facility a sub-critical Accelerator- Driven System (ADS) for nuclear energy research facility description and an overview of the research program (1997-2008).

    Energy Technology Data Exchange (ETDEWEB)

    Gohar, Y.; Smith, D. L.; Nuclear Engineering Division

    2010-04-28

    The YALINA facility is a zero-power, sub-critical assembly driven by a conventional neutron generator. It was conceived, constructed, and put into operation at the Radiation Physics and Chemistry Problems Institute of the National Academy of Sciences of Belarus located in Minsk-Sosny, Belarus. This facility was conceived for the purpose of investigating the static and dynamic neutronics properties of accelerator driven sub-critical systems, and to serve as a neutron source for investigating the properties of nuclear reactions, in particular transmutation reactions involving minor-actinide nuclei. This report provides a detailed description of this facility and documents the progress of research carried out there during a period of approximately a decade since the facility was conceived and built until the end of 2008. During its history of development and operation to date (1997-2008), the YALINA facility has hosted several foreign groups that worked with the resident staff as collaborators. The participation of Argonne National Laboratory in the YALINA research programs commenced in 2005. For obvious reasons, special emphasis is placed in this report on the work at YALINA facility that has involved Argonne's participation. Attention is given here to the experimental program at YALINA facility as well as to analytical investigations aimed at validating codes and computational procedures and at providing a better understanding of the physics and operational behavior of the YALINA facility in particular, and ADS systems in general, during the period 1997-2008.

  17. Stakeholders in psychiatry and their attitudes toward receiving pertinent and incident findings in genomic research

    DEFF Research Database (Denmark)

    Sundby, Anna; Boolsen, Merete Watt; Burgdorf, Kristoffer Solvsten

    2017-01-01

    potential research participants and health professionals toward receiving pertinent and incidental findings. A cross-sectional online survey was developed to investigate the attitudes among research participants toward receiving genomic findings. A total of 2,637 stakeholders responded: 241 persons...... and information that is not of serious health importance. Psychiatrists and clinical geneticists were less positive about receiving genomic findings compared with blood donors. The attitudes toward receiving findings were very positive. Stakeholders were willing to refrain from receiving incidental information......Increasingly more psychiatric research studies use whole genome sequencing or whole exome sequencing. Consequently, researchers face difficult questions, such as which genomic findings to return to research participants and how. This study aims to gain more knowledge on the attitudes among...

  18. Science and Engineering Research Council Central Laser Facility

    International Nuclear Information System (INIS)

    1981-03-01

    This report covers the work done at, or in association with, the Central Laser Facility during the year April 1980 to March 1981. In the first chapter the major reconstruction and upgrade of the glass laser, which has been undertaken in order to increase the versatility of the facility, is described. The work of the six groups of the Glass Laser Scientific Progamme and Scheduling Committee is described in further chapters entitled; glass laser development, laser plasma interactions, transport and particle emission studies, ablative acceleration and compression studies, spectroscopy and XUV lasers, and theory and computation. Publications based on the work of the facility which have either appeared or been accepted for publication during the year are listed. (U.K.)

  19. Current Status and Issues of Nuclear Engineering Research and Educational Facilities in Universities

    International Nuclear Information System (INIS)

    2004-01-01

    It is important to discuss about nuclear engineering research and educational facilities in universities after new educational foundation. 12 universities investigated issues and a countermeasure of them. The results of a questionnaire survey, issues and countermeasure are shown in this paper. The questionnaire on the future nuclear researches, development of education, project, maintenance of nuclear and radioactive facilities and accelerator, control of uranium in subcritical test facilities, use of new corporation facilities, the fixed number of student, number of graduate, student experiments, themes of experiments and researches, the state of educational facilities are carried out. The results of questionnaire were summarized as followings: the fixed number of student (B/M/D) on nuclear engineering, exercise of reactor, education, themes, educational and research facilities, significance of nuclear engineering education in university and proposal. (S.Y.)

  20. Research and development activities of a neutron generator facility

    International Nuclear Information System (INIS)

    Darsono Sudjatmoko; Pramudita Anggraita; Sukarman Aminjoyo

    2000-01-01

    The neutron generator facility at YNRC is used for elemental analysis, nuclear data measurement and education. In nuclear data measurement the focus is on re-evaluating the existing scattered nuclear activation cross-section to obtain systematic data for nuclear reactions such as (n,p), (n,α), and (n,2n). In elemental analysis it is used for analyzing the Nitrogen (N), Phosphor (P) and Potassium (K) contents in chemical and natural fertilizers (compost), protein in rice, soybean, and corn and pollution level in rivers. The neutron generator is also used for education and training of BATAN staff and university students. The facility can also produce neutron generator components. (author)

  1. Development of new irradiation facility for BWR safety research

    International Nuclear Information System (INIS)

    Okada, Yuji; Magome, Hirokatsu; Iida, Kazuhiro; Hanawa, Hiroshi; Ohmi, Masao

    2013-01-01

    In JAEA (Japan Atomic Energy Agency), about the irradiation embrittlement of the reactor pressure vessel and the stress corrosion cracking of reactor core composition apparatus concerning the long-term use of the light water reactor (BWR), in order to check the influence of the temperature, pressure, and water quality, etc on BWR condition. The water environmental control facility which performs irradiation assisted stress corrosion-cracking (IASCC) evaluation under BWR irradiation environment was fabricated in JMTR (Japan Materials Testing Reactor). This report is described the outline of manufacture of the water environmental control facility for doing an irradiation test using the saturation temperature capsule after JMTR re-operation. (author)

  2. Researchers' preferences and attitudes on ethical aspects of genomics research: a comparative study between the USA and Spain.

    Science.gov (United States)

    Ruiz-Canela, M; Valle-Mansilla, J I; Sulmasy, D P

    2009-04-01

    The use of human samples in genomic research has increased ethical debate about informed consent (IC) requirements and the information that subjects should receive regarding the results of the research. However, there are no quantitative data regarding researchers' attitudes about these issues. We present the results of a survey of 104 US and 100 Spanish researchers who had published genomic epidemiology studies in 61 journals during 2006. Researchers preferred a broader IC than the IC they had actually obtained in their published papers. US authors were more likely than their Spanish colleagues to support obtaining a broad IC, covering either any future research project or any projects related to a group of diseases (67.6% vs 43%; adjusted OR = 4.84, 95% CI, 2.32 to 10.12). A slight majority of researchers (55.8%) supported informing participants about individual genomic results only if the reliability and clinical validity of the information had been established. Men were more likely than women to believe that patients should be informed of research results even if these conditions were not met (adjusted OR = 2.89, 95% CI = 1.46 to 5.72). This study provides evidence of a wide range of views among scientists regarding some controversial ethical issues related to genomic research, suggesting the need for more study, debate and education. In the interim, journals might consider including the investigators' policies regarding these ethical issues in the papers they publish in the field of genomic epidemiology.

  3. Attitudes of stakeholders in psychiatry towards the inclusion of children in genomic research.

    Science.gov (United States)

    Sundby, Anna; Boolsen, Merete Watt; Burgdorf, Kristoffer Sølvsten; Ullum, Henrik; Hansen, Thomas Folkmann; Mors, Ole

    2018-03-05

    Genomic sequencing of children in research raises complex ethical issues. This study aims to gain more knowledge on the attitudes towards the inclusion of children as research subjects in genomic research and towards the disclosure of pertinent and incidental findings to the parents and the child. Qualitative data were collected from interviews with a wide range of informants: experts engaged in genomic research, clinical geneticists, persons with mental disorders, relatives, and blood donors. Quantitative data were collected from a cross-sectional web-based survey among 1227 parents and 1406 non-parents who were potential stakeholders in psychiatric genomic research. Participants generally expressed positive views on children's participation in genomic research. The informants in the qualitative interviews highlighted the age of the child as a critical aspect when disclosing genetic information. Other important aspects were the child's right to an autonomous choice, the emotional burden of knowing imposed on both the child and the parents, and the possibility of receiving beneficial clinical information regarding the future health of the child. Nevertheless, there was no consensus whether the parent or the child should receive the findings. A majority of survey stakeholders agreed that children should be able to participate in genomic research. The majority agreed that both pertinent and incidental findings should be returned to the parents and to the child when of legal age. Having children does not affect the stakeholder's attitudes towards the inclusion of children as research subjects in genomic research. Our findings illustrate that both the child's right to autonomy and the parents' interest to be informed are important factors that are found valuable by the participants. In future guidelines governing children as subjects in genomic research, it would thus be essential to incorporate the child's right to an open future, including the right to receive

  4. Genomes

    National Research Council Canada - National Science Library

    Brown, T. A. (Terence A.)

    2002-01-01

    ... of genome expression and replication processes, and transcriptomics and proteomics. This text is richly illustrated with clear, easy-to-follow, full color diagrams, which are downloadable from the book's website...

  5. Matrix-assisted laser desorption/ionisation, time-of-flight mass spectrometry in genomics research.

    Directory of Open Access Journals (Sweden)

    Jiannis Ragoussis

    2006-07-01

    Full Text Available The beginning of this millennium has seen dramatic advances in genomic research. Milestones such as the complete sequencing of the human genome and of many other species were achieved and complemented by the systematic discovery of variation at the single nucleotide (SNP and whole segment (copy number polymorphism level. Currently most genomics research efforts are concentrated on the production of whole genome functional annotations, as well as on mapping the epigenome by identifying the methylation status of CpGs, mainly in CpG islands, in different tissues. These recent advances have a major impact on the way genetic research is conducted and have accelerated the discovery of genetic factors contributing to disease. Technology was the critical driving force behind genomics projects: both the combination of Sanger sequencing with high-throughput capillary electrophoresis and the rapid advances in microarray technologies were keys to success. MALDI-TOF MS-based genome analysis represents a relative newcomer in this field. Can it establish itself as a long-term contributor to genetics research, or is it only suitable for niche areas and for laboratories with a passion for mass spectrometry? In this review, we will highlight the potential of MALDI-TOF MS-based tools for resequencing and for epigenetics research applications, as well as for classical complex genetic studies, allele quantification, and quantitative gene expression analysis. We will also identify the current limitations of this approach and attempt to place it in the context of other genome analysis technologies.

  6. Genomic Research Data Generation, Analysis and Sharing – Challenges in the African Setting

    Directory of Open Access Journals (Sweden)

    Nicola Mulder

    2017-11-01

    Full Text Available Genomics is the study of the genetic material that constitutes the genomes of organisms. This genetic material can be sequenced and it provides a powerful tool for the study of human, plant and animal evolutionary history and diseases. Genomics research is becoming increasingly commonplace due to significant advances in and reducing costs of technologies such as sequencing. This has led to new challenges including increasing cost and complexity of data. There is, therefore, an increasing need for computing infrastructure and skills to manage, store, analyze and interpret the data. In addition, there is a significant cost associated with recruitment of participants and collection and processing of biological samples, particularly for large human genetics studies on specific diseases. As a result, researchers are often reluctant to share the data due to the effort and associated cost. In Africa, where researchers are most commonly at the study recruitment, determination of phenotypes and collection of biological samples end of the genomic research spectrum, rather than the generation of genomic data, data sharing without adequate safeguards for the interests of the primary data generators is a concern. There are substantial ethical considerations in the sharing of human genomics data. The broad consent for data sharing preferred by genomics researchers and funders does not necessarily align with the expectations of researchers, research participants, legal authorities and bioethicists. In Africa, this is complicated by concerns about comprehension of genomics research studies, quality of research ethics reviews and understanding of the implications of broad consent, secondary analyses of shared data, return of results and incidental findings. Additional challenges with genomics research in Africa include the inability to transfer, store, process and analyze large-scale genomics data on the continent, because this requires highly specialized skills

  7. NRX and NRU reactor research facilities and irradiation and examination charges

    International Nuclear Information System (INIS)

    1960-08-01

    This report details the irradiation and examination charges on the NRX and NRU reactors at the Chalk River Nuclear Labs. It describes the NRX and NRU research facilities available to external users. It describes the various experimental holes and loops available for research. It also outlines the method used to calculate the facilities charges and the procedure for applying to use the facilities as well as the billing procedures.

  8. Korean plasma-material interaction researches/facilities

    International Nuclear Information System (INIS)

    Chung, K.-S.; Woo, H.-J.; Cho, S.-G.

    2013-01-01

    Various PMI facilities have been developed recently in Korea, such as DiPS, MP2, ECR plasma, a segmented plasma torch system, e-beam accelerator, and the TReD (Transport and Removal experiment of Dust) device. In this paper, these devices are briefly to be explained in terms of objective and specifications along with initial experimental results. (J.P.N.)

  9. Non-European facilities for elementary particle physics research

    International Nuclear Information System (INIS)

    Mann, A.K.

    1983-01-01

    The facilities we now employ in high energy physics cover a broad spectrum of particle energies and intensities and provide therefore a multiplicity of probes with which to study the behavior of elementary particles. In general, the goal has been to achieve ever higher particle energies and intensities, with emphasis on energy, and to develop more versatile and more sensitive detectors with which to study the resultant particle-particle interactions. Most energy regimes that have been explored have yielded new, fundamental information which often becomes clearer and more easily developed when particle energies are further increased. In this talk I shall try to delineate the nature of those facilities in Canada, Japan and the U.S.A. It is useful, I believe, to begin with a brief discussion of the funding and management of facilities in those countries and a short summary of recent history. The main body of the talk concentrates on the present, planned and contemplated facilities of the major non-European accelerator laboratories, and address briefly the status of accelerator development. The concluding section will summarize the salient features of the discussion. (author)

  10. Conference on the research facilities for future nuclear power engineering

    International Nuclear Information System (INIS)

    Arkhangel'skij, N.V.

    1996-01-01

    The activity of the European nuclear society Conference (Belgium, June, 1996) is described. The main topics of 60 presented reports are the following ones: necessity of developing new experimental facilities and their parameters; financing prospects and international cooperation in this field

  11. The Use of Internet Facilities in Teaching and Research by ...

    African Journals Online (AJOL)

    The study investigates the use of internet facilities by the academic staff of School of Management and Information Technology (SMIT) in Modibbo Adama University of Technology (MAUTECH), Yola. Literatures have been reviewed based on the objectives of the study. The findings of the study will be used to improve ...

  12. Report on progress of researches by common utilization of JAERI nuclear facilities, for fiscal 1992

    International Nuclear Information System (INIS)

    1993-08-01

    The results of the joint researches by utilizing the facilities of JAERI in 1992 fiscal year were summarized. The number of research themes in 1992 was 247 cases. In this book, 166 reports are collected. (J.P.N.)

  13. Report on progress of researches by common utilization of JAERI nuclear facilities, for fiscal 1993

    International Nuclear Information System (INIS)

    1994-07-01

    The results of the joint researches by utilizing the facilities of JAERI in 1993 fiscal year were summarized. The number of research themes in 1993 was 228 cases. In this book, 243 reports are collected. (J.P.N.)

  14. My sister's keeper?: genomic research and the identifiability of siblings

    Directory of Open Access Journals (Sweden)

    Kohane Isaac S

    2008-07-01

    Full Text Available Abstract Background Genomic sequencing of SNPs is increasingly prevalent, though the amount of familial information these data contain has not been quantified. Methods We provide a framework for measuring the risk to siblings of a patient's SNP genotype disclosure, and demonstrate that sibling SNP genotypes can be inferred with substantial accuracy. Results Extending this inference technique, we determine that a very low number of matches at commonly varying SNPs is sufficient to confirm sib-ship, demonstrating that published sequence data can reliably be used to derive sibling identities. Using HapMap trio data, at SNPs where one child is homozygotic major, with a minor allele frequency ≤ 0.20, (N = 452684, 65.1% we achieve 91.9% inference accuracy for sibling genotypes. Conclusion These findings demonstrate that substantial discrimination and privacy risks arise from use of inferred familial genomic data.

  15. The upgrading of the cyclic neutron activation analysis facility at the Dalat research reactor

    International Nuclear Information System (INIS)

    Van Doanh Ho; Manh Dung Ho; Quang Thien Tran; Dong Vu Cao; Thanh Viet Ha

    2018-01-01

    The cyclic neutron activation analysis (CNAA) facility based on a pneumatic transfer system for short irradiation and rapid counting has recently been upgraded at the Dalat research reactor. The original facility was only designed for single irradiation. Therefore, this work has aimed to upgrade both hardware and software for the cyclic irradiation. In this paper, the upgrading of the facility for CNAA was described. Irradiation time of the facility were calibrated, thereby reducing irradiation time to seconds with precision. The accuracy and sensitivity of CNAA based-on the upgraded facility were assessed by determination of some short-lived nuclides. (author)

  16. Survey of tritium wastes and effluents in near-term fusion-research facilities

    International Nuclear Information System (INIS)

    Bickford, W.E.; Dingee, D.A.; Willingham, C.E.

    1981-08-01

    The use of tritium control technology in near-term research facilities has been studied for both the magnetic and inertial confinement fusion programs. This study focused on routine generation of tritium wastes and effluents, with little referene to accidents or facility decommissioning. This report serves as an independent review of the effectiveness of planned control technology and radiological hazards associated with operation. The facilities examined for the magnetic fusion program included Fusion Materials Irradiation Testing Facility (FMIT), Tritium Systems Test Assembly (TSTA), and Tokamak Fusion Test Reactor (TFTR) in the magnetic fusion program, while NOVA and Antares facilities were examined for the inertial confinement program

  17. Rabbit models for biomedical research revisited via genome editing approaches

    OpenAIRE

    HONDA, Arata; OGURA, Atsuo

    2017-01-01

    Although the laboratory rabbit has long contributed to many paradigmatic studies in biology and medicine, it is often considered to be a “classical animal model” because in the last 30 years, the laboratory mouse has been more often used, thanks to the availability of embryonic stem cells that have allowed the generation of gene knockout (KO) animals. However, recent genome-editing strategies have changed this unrivaled condition; so far, more than 10 mammalian species have been added to the ...

  18. Yearly program of safety research in nuclear power facilities from fiscal 1981 to 1985

    International Nuclear Information System (INIS)

    Anon.

    1984-01-01

    Nuclear safety research plans for nuclear power facilities and others from fiscal 1981 to 1985 are presented for the following areas: the safety of LWR fuel, loss-of-coolant accidents, the structural safety of LWR installations, the reduction of radioactive material release from nuclear power facilities, the stochastic safety evaluation of nuclear power facilities, the aseismicity of nuclear power facilities, the safety of nuclear fuel facilities, and the safety of nuclear fuel transport vessels. In the respective areas, the needs for research and the outline of research works are summarized. Then, about the major research works in each area, the purpose, contents, term and responsible institution of the research are given. (Mori, K.)

  19. GRAbB: Selective Assembly of Genomic Regions, a New Niche for Genomic Research.

    Directory of Open Access Journals (Sweden)

    Balázs Brankovics

    2016-06-01

    Full Text Available GRAbB (Genomic Region Assembly by Baiting is a new program that is dedicated to assemble specific genomic regions from NGS data. This approach is especially useful when dealing with multi copy regions, such as mitochondrial genome and the rDNA repeat region, parts of the genome that are often neglected or poorly assembled, although they contain interesting information from phylogenetic or epidemiologic perspectives, but also single copy regions can be assembled. The program is capable of targeting multiple regions within a single run. Furthermore, GRAbB can be used to extract specific loci from NGS data, based on homology, like sequences that are used for barcoding. To make the assembly specific, a known part of the region, such as the sequence of a PCR amplicon or a homologous sequence from a related species must be specified. By assembling only the region of interest, the assembly process is computationally much less demanding and may lead to assemblies of better quality. In this study the different applications and functionalities of the program are demonstrated such as: exhaustive assembly (rDNA region and mitochondrial genome, extracting homologous regions or genes (IGS, RPB1, RPB2 and TEF1a, as well as extracting multiple regions within a single run. The program is also compared with MITObim, which is meant for the exhaustive assembly of a single target based on a similar query sequence. GRAbB is shown to be more efficient than MITObim in terms of speed, memory and disk usage. The other functionalities (handling multiple targets simultaneously and extracting homologous regions of the new program are not matched by other programs. The program is available with explanatory documentation at https://github.com/b-brankovics/grabb. GRAbB has been tested on Ubuntu (12.04 and 14.04, Fedora (23, CentOS (7.1.1503 and Mac OS X (10.7. Furthermore, GRAbB is available as a docker repository: brankovics/grabb (https://hub.docker.com/r/brankovics/grabb/.

  20. Annual report of the research works with joint-use JAERI facilities for fiscal 1974

    International Nuclear Information System (INIS)

    1975-01-01

    Results of the research works by national universities with JAERI's (Japan Atomic Energy Research Institute) joint-use facilities for fiscal 1974 are described. Facilities are research reactors, Co-60, Linac, etc. Research results are presented in individual summaries, covering radiation damage and solid state physics, activation analysis and nuclear chemistry, irradiation effects, etc. Results of the joint works with JAERI are also presented similarly. (Mori, K.)

  1. NATO Advanced Research Workshop on Brilliant Light Facilities and Research in Life and Material Sciences

    CERN Document Server

    Tsakanov, Vasili; Brilliant Light in Life and Material Sciences

    2007-01-01

    The present book contains an excellent overview of the status and highlights of brilliant light facilities and their applications in biology, chemistry, medicine, materials and environmental sciences. Overview papers on diverse fields of research by leading experts are accompanied by the highlights in the near and long-term perspectives of brilliant X-Ray photon beam usage for fundamental and applied research. The book includes advanced topics in the fields of high brightness photon beams, instrumentation, the spectroscopy, microscopy, scattering and imaging experimental techniques and their applications. The book is strongly recommended for students, engineers and scientists in the field of accelerator physics, X-ray optics and instrumentation, life, materials and environmental sciences, bio and nanotechnology.

  2. Planetary physics research programme at the Facility for Antiprotons and Ion Research at Darmstadt

    Energy Technology Data Exchange (ETDEWEB)

    Tahir, N.A.; Neumayer, P.; Bagnoud, V. [Department of Plasma Physics, GSI Helmholtzzentrum fuer Schwerionenforschung, Darmstadt (Germany); Lomonosov, I.V. [Institute of Problems of Chemical Physics, Russian Academy of Sciences, Chernogolovka (Russian Federation); Tomsk University, Tomsk (Russian Federation); Lomonosov Moscow State University, Moscow (Russian Federation); Moscow Institute of Physics and Technology, Dolgoprudny (Russian Federation); Borm, B. [Department of Physics, Goethe-Universitaet Frankfurt, Frankfurt (Germany); Piriz, A.R.; Piriz, S.A. [E.T.S.I. Industrials, University of Castilla-La Mancha, Ciudad Real (Spain); Shutov, A. [Institute of Problems of Chemical Physics, Russian Academy of Sciences, Chernogolovka (Russian Federation)

    2017-11-15

    Planetary physics research is an important part of the high energy density (HED) physics programme at the Facility for Antiprotons and Ion Research (FAIR) at Darmstadt. In this paper, we report numerical simulations of a proposed experiment named LAboratory PLAnetary Sciences (LAPLAS). These simulations show that in such experiments, an Fe sample can be imploded to extreme physical conditions that are expected to exist in the interior of the Earth and in the interior of more massive rocky planets named, super-Earths. The LAPLAS experiments will thus provide very valuable information on the equation-of-state (EOS) and transport properties of HED Fe, which will help the scientists to understand the structure and evolution of the planets in our solar system and of the extrasolar system planets. (copyright 2017 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

  3. Planetary physics research programme at the Facility for Antiprotons and Ion Research at Darmstadt

    International Nuclear Information System (INIS)

    Tahir, N.A.; Neumayer, P.; Bagnoud, V.; Lomonosov, I.V.; Borm, B.; Piriz, A.R.; Piriz, S.A.; Shutov, A.

    2017-01-01

    Planetary physics research is an important part of the high energy density (HED) physics programme at the Facility for Antiprotons and Ion Research (FAIR) at Darmstadt. In this paper, we report numerical simulations of a proposed experiment named LAboratory PLAnetary Sciences (LAPLAS). These simulations show that in such experiments, an Fe sample can be imploded to extreme physical conditions that are expected to exist in the interior of the Earth and in the interior of more massive rocky planets named, super-Earths. The LAPLAS experiments will thus provide very valuable information on the equation-of-state (EOS) and transport properties of HED Fe, which will help the scientists to understand the structure and evolution of the planets in our solar system and of the extrasolar system planets. (copyright 2017 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

  4. Direct sunlight facility for testing and research in HCPV

    International Nuclear Information System (INIS)

    Sciortino, Luisa; Agnello, Simonpietro; Bonsignore, Gaetano; Cannas, Marco; Gelardi, Franco Mario; Napoli, Gianluca; Spallino, Luisa; Barbera, Marco; Buscemi, Alessandro; Montagnino, Fabio Maria; Paredes, Filippo; Candia, Roberto; Collura, Alfonso; Di Cicca, Gaspare; Cicero, Ugo Lo; Varisco, Salvo

    2014-01-01

    A facility for testing different components for HCPV application has been developed in the framework of 'Fotovoltaico ad Alta Efficienza' (FAE) project funded by the Sicilian Regional Authority (PO FESR Sicilia 2007/2013 4.1.1.1). The testing facility is equipped with an heliostat providing a wide solar beam inside the lab, an optical bench for mounting and aligning the HCPV components, electronic equipments to characterize the I-V curves of multijunction cells operated up to 2000 suns, a system to circulate a fluid in the heat sink at controlled temperature and flow-rate, a data logging system with sensors to measure temperatures in several locations and fluid pressures at the inlet and outlet of the heat sink, and a climatic chamber with large test volume to test assembled HCPV modules

  5. Hypervelocity Expansion Facility for Fundamental High-Enthalpy Research

    Science.gov (United States)

    2017-02-27

    ii Final Technical Report of Contract ONR N00014-15-1-2260 Entitled: HYPERVELOCITY EXPANSION FACILITY FOR FUNDAMENTAL HIGH-ENTHALPY...previous DoD investments in high-energy pulsed laser diagnostics for instantaneous planar velocimetry and thermometry to perform scientific studies of...capability for fundamental and applied studies of hypervelocity high enthalpy flows. In this document, we report on the progress over the 18-month

  6. Phytochrome-mediated responses: Implications for controlled environment research facilities

    Science.gov (United States)

    Smith, Harry

    1994-01-01

    Light is undoubtedly the most important environmental variable for plant growth and development; plants not only use radiant energy in photosynthesis, they also respond to the quantity, quality, direction and timing of incident radiation through photomorphogenic response that can have huge effects on the rate of growth and the pattern of development. It is surprising, therefore, that the manufacturers and suppliers of controlled environment facilities have been singularly uninventive in the design of the lighting assemblies they provide. The consumer has one choice only - a lighting assembly that provides irradiance levels usually only a fraction of sunlight, and a control system that is limited to regulating the timing of the on-off switch. The reasons for these limitations are partly technological, but in the main they result from ignorance on the part of both the consumer and the manufacturer. A specific and powerful example of this ignorance relates to the importance of the so-called far-red wavelengths (FR = 700-800 nm). Because the human eye can hardly detect wavelengths above 700 nm, and photosynthesis also cuts off at about 700 nm, the majority of plant and crop physiologists are still almost completely unaware that FR radiation can have massive effects on growth rate and development. In consequence, most growth cabinets have light sources based on fluorescent tubes, and provide very little FR apart from that emitted by a token number of small incandescent bulbs. Larger growth facilities often use broader spectrum light sources, but growth facilities that provide the capability to vary the FR incident upon the plants are about as abundant as seals in the Sahara. This article sets the background of the significance of FR radiation in the natural environment and its importance for plant growth and development in the hope that it might inform intelligently those concerned with improving the design of plant growth facilities.

  7. Phytochrome-mediated responses implications for controlled environment research facilities

    Energy Technology Data Exchange (ETDEWEB)

    Smith, H. [Univ. of Leicester (United Kingdom)

    1994-12-31

    Light is undoubtedly the most important environmental variable for plant growth and development; plants not only use radiant energy in photosynthesis, they also respond to the quantity, quality, direction and timing of incident radiation through photomorphogenic responses that can have huge effects on the rate of growth and the pattern of development. It is surprising, therefore, that the manufacturers and suppliers of controlled environment facilities have been singularly uninventive in the design of the lighting assemblies they provide. The consumer has one choice only - a lighting assembly that provides irradiance levels usually only a fraction of sunlight, and a control system that is limited to regulating the timing of the on-off switch. The reasons for these limitations are partly technological, but in the main they result from ignorance on the part of both the consumer and the manufacturer. A specific and powerful example of this ignorance relates to the importance of the so-called far-red wavelengths (FR = 700-800 nm). Because the human eye can hardly detect wavelengths above 700 nm, and photosynthesis also cuts off at ca. 700 mn, the majority of plant and crop physiologists are still almost completely unaware that FR radiation can have massive effects on growth rate and development. In consequence, most growth cabinets have light sources based on fluorescent tubes, and provide very little FR apart from that emitted by a token number of small incandescent bulbs. Larger growth facilities often use broader spectrum light sources, but growth facilities that provide the capability to vary the FR incident upon the plants are about as abundant as seals in the Sahara. This article sets the background of the significance of FR radiation in the natural environment and its importance for plant growth and development in the hope that it might inform intelligently those concerned with improving the design of plant growth facilities.

  8. Using a Historical Lens to Envision the Next Generation of Genomic Translation Research.

    Science.gov (United States)

    McBride, Colleen M; Abrams, Leah R; Koehly, Laura M

    2015-01-01

    The past 20 years have witnessed successive and exponential advances in genomic discovery and technology, with a broad scientific imperative pushing for continual advancements. The most consistent critique of these advances is that they have vastly outpaced translation of new knowledge into improvements in public health and medicine. We employ a historical and epistemological analysis to characterize how prevailing scientific meta-narratives have shaped the pace and priorities of research applying genomics to health promotion. We use four 'pivotal events' - the genetic characterization of Down syndrome, the launch of the Human Genome Research Project, the discovery of BRCA1, and the emergence of direct-to- consumer genetic testing - to illustrate how these scientific meta-narratives have inhibited genomic translation research. The notion that discovery should precede translation research has over-focused translation research on the latest genetic testing platform. The idea that genetic-related research has an exceptional potential for public harm has encouraged research on worst case scenarios. The perceived competition between genetics and social determinants of health has discouraged a unified research agenda to move genomic translation forward. We make a case for creating new scientific meta-narratives in which discovery and translation research agendas are envisioned as an interdependent enterprise. © 2015 S. Karger AG, Basel.

  9. The Budapest research reactor as an advanced research facility for the early 21st century

    International Nuclear Information System (INIS)

    Vidovszky, I.

    2001-01-01

    The Budapest Research Reactor, Hungary's first nuclear facility was originally put into operation in 1959. The reactor serves for: basic and applied research, technological and commercial applications, education and training. The main goal of the reactor is to serve neutron research. This unique research possibility is used by a broad user community of Europe. Eight instruments for neutron scattering, radiography and activation analyses are already used, others (e.g. time of flight spectrometer, neutron reflectometer) are being installed. The majority of these instruments will get a much improved utilization when the cold neutron source is put into operation. In 1999 the Budapest Research Reactor was operated for 3129 full power hours in 14 periods. The normal operation period took 234 hours (starting Monday noon and finishing Thursday morning). The entire production for the year 1999 was 1302 MW days. This is a slightly reduced value, due to the installation of the cold neutron source. For the year 2000 a somewhat longer operation is foreseen (near to 4000 hours), as the cold neutron source will be operational. The operation of the reactor is foreseen at least up to the end of the first decade of the 21 st century. (author)

  10. Transmission of different variants of PCV2 and viral dynamics in a research facility with pigs mingled from PMWS-affected herds and non-affected herds

    DEFF Research Database (Denmark)

    Dupont, Kitt; Hjulsager, Charlotte Kristiane; Kristensen, C.S.

    2009-01-01

    Post-weaning Multisystemic Wasting Syndrome (PMWS) has been identified in most swine-producing countries worldwide. The disease has resulted in significant health challenges and economic damage to the swine industry. The aim of this study was to determine horizontal transmission of porcine...... the aisle and pens in other compartments). By DNA sequence analysis, eight variants of genotype PCV-2b were identified in the research facility. From the spread of these PCV2-variants it was concluded that PCV2 primarily infects through close contact and nose-to-nose contact. PCV2 genome sequences were...... obtained from selected pigs at arrival to the research facility and again when the same pigs developed PMWS. This analysis showed that pigs from PMWS-affected herds developed PMWS caused by the same variant of PCV2 as they carried when entering the research facility. In contrast, pigs from non...

  11. The technological study on the decommissioning of nuclear facility, etc. in the Tokai Research Establishment

    International Nuclear Information System (INIS)

    Tomii, Hiroyuki; Matsuo, Kiyoshi; Shiraishi, Kunio; Kato, Rokuro; Watabe, Kozou; Higashiyama, Yutaka; Nagane, Satoru

    2005-03-01

    Since JPDR is dismantled and is removed, in Tokai Research Establishment, Japan Atomic Energy Research Institute, the dismantling of nuclear facility which finished the mission, etc. is advanced. At present, nuclear facility as a dismantling object count the approximately 20 facilities, and decommissioning plan of these facilities becomes an important problem, when the decommissioning countermeasure is considered. However, decommissioning techniques in proportion to various nuclear facility, etc. are clearly, and it has not been determined. In this report, the technical consideration on decommissioning techniques of nuclear facility promoted on the basis of this experience in future, while until now decommissioning experience and technical knowledge are arranged, etc. was added in order to appropriately and surely carry out decommissioning techniques and legal procedures, etc. (author)

  12. Proposal for a seismic facility for reactor safety research

    International Nuclear Information System (INIS)

    Anderson, C.A.; Dove, R.C.; Rhorer, R.L.

    1976-07-01

    Certain problem areas in the seismic analysis and design of nuclear reactors are enumerated and the way in which an experimental program might contribute to each area is examined. The use of seismic simulation testing receives particular attention, especially with regard to the verification of structural response analysis. The importance of scale modeling used in conjunction with seismic simulation is also stressed. The capabilities of existing seismic simulators are summarized, and a proposed facility is described which would considerably extend the ability to conduct, with confidence, confirmatory experiments on the behavior of reactor components when subjected to seismic excitation. Particular applications to gas-cooled and other reactor types are described

  13. A pulsed neutron facility for condensed matter research

    International Nuclear Information System (INIS)

    Hobbis, L.C.W.; Rees, G.H.; Stirling, G.C.

    1977-06-01

    The scientific and technical basis of the project is presented, as follows: broad synopsis of the proposal for a spallation neutron facility; description of neutron scattering and current work in the UK; scientific applications of the Spallation Neutron Source; discussion of various types of neutron sources; outline description of the SNS and its neutron performance parameters; appendix dealing in more detail with utilization (solid state physics, fluids and amorphous solids, structure determination, molecular and biological sciences); appendix dealing in more detail with the project design (800 MeV synchrotron, target station, shielding, radioactivity and radiation damage, utilization, overall programme). (U.K.)

  14. Genome mining offers a new starting point for parasitology research.

    Science.gov (United States)

    Lv, Zhiyue; Wu, Zhongdao; Zhang, Limei; Ji, Pengyu; Cai, Yifeng; Luo, Shiqi; Wang, Hongxi; Li, Hao

    2015-02-01

    Parasites including helminthes, protozoa, and medical arthropod vectors are a major cause of global infectious diseases, affecting one-sixth of the world's population, which are responsible for enormous levels of morbidity and mortality important and remain impediments to economic development especially in tropical countries. Prevalent drug resistance, lack of highly effective and practical vaccines, as well as specific and sensitive diagnostic markers are proving to be challenging problems in parasitic disease control in most parts of the world. The impressive progress recently made in genome-wide analysis of parasites of medical importance, including trematodes of Clonorchis sinensis, Opisthorchis viverrini, Schistosoma haematobium, S. japonicum, and S. mansoni; nematodes of Brugia malayi, Loa loa, Necator americanus, Trichinella spiralis, and Trichuris suis; cestodes of Echinococcus granulosus, E. multilocularis, and Taenia solium; protozoa of Babesia bovis, B. microti, Cryptosporidium hominis, Eimeria falciformis, E. histolytica, Giardia intestinalis, Leishmania braziliensis, L. donovani, L. major, Plasmodium falciparum, P. vivax, Trichomonas vaginalis, Trypanosoma brucei and T. cruzi; and medical arthropod vectors of Aedes aegypti, Anopheles darlingi, A. sinensis, and Culex quinquefasciatus, have been systematically covered in this review for a comprehensive understanding of the genetic information contained in nuclear, mitochondrial, kinetoplast, plastid, or endosymbiotic bacterial genomes of parasites, further valuable insight into parasite-host interactions and development of promising novel drug and vaccine candidates and preferable diagnostic tools, thereby underpinning the prevention and control of parasitic diseases.

  15. Annual report of intra-university joint-use facilities management and research for fiscal 1974

    International Nuclear Information System (INIS)

    1975-01-01

    Usage of RCNST's (Research Center for Nuclear Science and Technology) facilities by the University of Tokyo and results of the research works in fiscal 1974 are described. In the former are included facility operation, maintenance, etc. and frequency of usage. Comprising the fields of biology/medicine, chemistry/physics, engineering, materials, nuclear physics, etc., the research results are presented in individual summaries. (Mori, K.)

  16. Report on progress of researches by common utilization of JAERI nuclear facilities, for fiscal 1982

    International Nuclear Information System (INIS)

    1983-01-01

    The utilization of the facilities in the Japan Atomic Energy Research Institute in common in 1982 has finished in active state, and the results of the researches have reached the stage of publication. The subjects of the researches spread over wide fields, and in 1982 also, extremely diversified researches were carried out. In this report, theses results were collected in one book, and it is desirable to utilize it actively. The number of the research themes is 131. In the field of general researches, the researches on radiochemistry, the utilization of radiation and the effects of irradiation were mostly carried out, while in cooperative researches, the researches were mainly concerned with nuclear reactor engineering and nuclear reactor materials. The total number of visitors was 3025. The facilities offered to the common utilization were JRR-2, JRR-3, JRR-4, Co-60 irradiation facility and others. The abstracts of the papers are reported. (J.P.N.)

  17. MIPS PlantsDB: a database framework for comparative plant genome research.

    Science.gov (United States)

    Nussbaumer, Thomas; Martis, Mihaela M; Roessner, Stephan K; Pfeifer, Matthias; Bader, Kai C; Sharma, Sapna; Gundlach, Heidrun; Spannagl, Manuel

    2013-01-01

    The rapidly increasing amount of plant genome (sequence) data enables powerful comparative analyses and integrative approaches and also requires structured and comprehensive information resources. Databases are needed for both model and crop plant organisms and both intuitive search/browse views and comparative genomics tools should communicate the data to researchers and help them interpret it. MIPS PlantsDB (http://mips.helmholtz-muenchen.de/plant/genomes.jsp) was initially described in NAR in 2007 [Spannagl,M., Noubibou,O., Haase,D., Yang,L., Gundlach,H., Hindemitt, T., Klee,K., Haberer,G., Schoof,H. and Mayer,K.F. (2007) MIPSPlantsDB-plant database resource for integrative and comparative plant genome research. Nucleic Acids Res., 35, D834-D840] and was set up from the start to provide data and information resources for individual plant species as well as a framework for integrative and comparative plant genome research. PlantsDB comprises database instances for tomato, Medicago, Arabidopsis, Brachypodium, Sorghum, maize, rice, barley and wheat. Building up on that, state-of-the-art comparative genomics tools such as CrowsNest are integrated to visualize and investigate syntenic relationships between monocot genomes. Results from novel genome analysis strategies targeting the complex and repetitive genomes of triticeae species (wheat and barley) are provided and cross-linked with model species. The MIPS Repeat Element Database (mips-REdat) and Catalog (mips-REcat) as well as tight connections to other databases, e.g. via web services, are further important components of PlantsDB.

  18. Overview of the Defense Programs Research and Technology Development Program for fiscal year 1993. Appendix II research laboratories and facilities

    Energy Technology Data Exchange (ETDEWEB)

    1993-09-30

    This document contains summaries of the research facilities that support the Defense Programs Research and Technology Development Program for FY 1993. The nine program elements are aggregated into three program clusters as follows: (1) Advanced materials sciences and technologies; chemistry and materials, explosives, special nuclear materials (SNM), and tritium. (2) Design sciences and advanced computation; physics, conceptual design and assessment, and computation and modeling. (3) Advanced manufacturing technologies and capabilities; system engineering science and technology, and electronics, photonics, sensors, and mechanical components. Section I gives a brief summary of 23 major defense program (DP) research and technology facilities and shows how these major facilities are organized by program elements. Section II gives a more detailed breakdown of the over 200 research and technology facilities being used at the Laboratories to support the Defense Programs mission.

  19. Attitudes of stakeholders in psychiatry towards the inclusion of children in genomic research

    DEFF Research Database (Denmark)

    Sundby, Anna; Boolsen, Merete Watt; Burgdorf, Kristoffer Sølvsten

    2018-01-01

    BACKGROUND: Genomic sequencing of children in research raises complex ethical issues. This study aims to gain more knowledge on the attitudes towards the inclusion of children as research subjects in genomic research and towards the disclosure of pertinent and incidental findings to the parents...... age. Having children does not affect the stakeholder's attitudes towards the inclusion of children as research subjects in genomic research. CONCLUSION: Our findings illustrate that both the child's right to autonomy and the parents' interest to be informed are important factors that are found...... disclosing genetic information. Other important aspects were the child's right to an autonomous choice, the emotional burden of knowing imposed on both the child and the parents, and the possibility of receiving beneficial clinical information regarding the future health of the child. Nevertheless...

  20. User Facilities of the Office of Basic Energy Sciences: A National Resource for Scientific Research

    Energy Technology Data Exchange (ETDEWEB)

    None

    2009-01-01

    The BES user facilities provide open access to specialized instrumentation and expertise that enable scientific users from universities, national laboratories, and industry to carry out experiments and develop theories that could not be done at their home institutions. These forefront research facilities require resource commitments well beyond the scope of any non-government institution and open up otherwise inaccessible facets of Nature to scientific inquiry. For approved, peer-reviewed projects, instrument time is available without charge to researchers who intend to publish their results in the open literature. These large-scale user facilities have made significant contributions to various scientific fields, including chemistry, physics, geology, materials science, environmental science, biology, and biomedical science. Over 16,000 scientists and engineers.pdf file (27KB) conduct experiments at BES user facilities annually. Thousands of other researchers collaborate with these users and analyze the data measured at the facilities to publish new scientific findings in peer-reviewed journals.

  1. Report on progress of researches by common utilization of JAERI nuclear facilities, for fiscal 1988

    International Nuclear Information System (INIS)

    1989-01-01

    In 1988, this system called 'Common utilization of JAERI facilities' so far was changed to 'Joint research utilizing JAERI facilities', and by evaluating more positively the function of the General Research Center for Nuclear Energy, it has been emphasized to promote and coordinate the joint research among universities centering around the utilization of JAERI facilities. The total number of the research subjects in fiscal year 1988 reached 138, but the results of 120 of them are collected in this book. General joint research is the standard form of the utilization of various facilities that JAERI has opened to common utilization. Cooperation research is to be carried out by concluding research cooperation contracts between university researchers and JAERI researchers, and the facilities which are not opened to common utilization can be used. In the general joint research, the utilization of irradiation such as activation analysis, radiochemistry, irradiation effect, neutron diffraction and so on and the research using beams are mostly carried out, but in the cooperation research, reactor engineering, reactor materials,, nuclear physics measurement and so on are the main subjects. The total number of visitors in one year was 3829 man-day. (K.I.)

  2. Solar Radiation Research Laboratory | Energy Systems Integration Facility |

    Science.gov (United States)

    Solar Radiation Research Laboratory (SRRL) has been collecting continuous measurements of basic solar continuous operation. More than 75 instruments contribute to the Baseline Measurement System by recording

  3. Facility Design and Health Management Program at the Sinnhuber Aquatic Research Laboratory.

    Science.gov (United States)

    Barton, Carrie L; Johnson, Eric W; Tanguay, Robert L

    2016-07-01

    The number of researchers and institutions moving to the utilization of zebrafish for biomedical research continues to increase because of the recognized advantages of this model. Numerous factors should be considered before building a new or retooling an existing facility. Design decisions will directly impact the management and maintenance costs. We and others have advocated for more rigorous approaches to zebrafish health management to support and protect an increasingly diverse portfolio of important research. The Sinnhuber Aquatic Research Laboratory (SARL) is located ∼3 miles from the main Oregon State University campus in Corvallis, Oregon. This facility supports several research programs that depend heavily on the use of adult, larval, and embryonic zebrafish. The new zebrafish facility of the SARL began operation in 2007 with a commitment to build and manage an efficient facility that diligently protects human and fish health. An important goal was to ensure that the facility was free of Pseudoloma neurophilia (Microsporidia), which is very common in zebrafish research facilities. We recognize that there are certain limitations in space, resources, and financial support that are institution dependent, but in this article, we describe the steps taken to build and manage an efficient specific pathogen-free facility.

  4. Scientific user facilities at Oak Ridge National Laboratory: New research capabilities and opportunities

    Science.gov (United States)

    Roberto, James

    2011-10-01

    Over the past decade, Oak Ridge National Laboratory (ORNL) has transformed its research infrastructure, particularly in the areas of neutron scattering, nanoscale science and technology, and high-performance computing. New facilities, including the Spallation Neutron Source, Center for Nanophase Materials Sciences, and Leadership Computing Facility, have been constructed that provide world-leading capabilities in neutron science, condensed matter and materials physics, and computational physics. In addition, many existing physics-related facilities have been upgraded with new capabilities, including new instruments and a high- intensity cold neutron source at the High Flux Isotope Reactor. These facilities are operated for the scientific community and are available to qualified users based on competitive peer-reviewed proposals. User facilities at ORNL currently welcome more than 2,500 researchers each year, mostly from universities. These facilities, many of which are unique in the world, will be reviewed including current and planned research capabilities, availability and operational performance, access procedures, and recent research results. Particular attention will be given to new neutron scattering capabilities, nanoscale science, and petascale simulation and modeling. In addition, user facilities provide a portal into ORNL that can enhance the development of research collaborations. The spectrum of partnership opportunities with ORNL will be described including collaborations, joint faculty, and graduate research and education.

  5. Recent LAMPF [Los Alamos Meson Physics Facility] research using muons

    International Nuclear Information System (INIS)

    Bradbury, J.N.

    1987-01-01

    In addition to the core programs in nuclear and particle physics, diverse experiments have been carried out that address interdisciplinary and applied topics at the Los Alamos Meson Physics Facility (LAMPF). These include muon-spin-relaxation experiments to study magnetic dynamics in spin glasses and electronic structure in heavy-fermion superconductors; muon channeling experiments to provide information on pion stopping sites in crystals; tomographic density reconstruction studies using proton energy loss; and radiation-effects experiments to explore microstructure evolution and to characterize materials for fusion devices and high-intensity accelerators. Finally, the catalysis of the d-t fusion reaction using negative muons has been extensively investigated with some surprising results including a stronger than linear dependence of the mesomolecular formation rate on target density and the observation of 150 fusions per muon under certain conditions. Recent results in those programs involving pions and muons interacting with matter are discussed

  6. Characterization of the fast neutron irradiation facility of the Portuguese Research Reactor after core conversion

    International Nuclear Information System (INIS)

    Marques, J.G.; Sousa, M.; Santos, J.P.; Fernandes, A.C.

    2011-01-01

    The fast neutron irradiation facility of the Portuguese Research Reactor was characterized after the reduction in uranium enrichment and rearrangement of the core configuration. In this work we report on the determination of the hardness parameter and the 1 MeV equivalent neutron flux along the facility, in the new irradiation conditions, following ASTM E722 standard.

  7. Characterization of BIPV(T) applications in research facility ‘SOLARBEAT’

    NARCIS (Netherlands)

    Valckenborg, R.M.E.; Hensen, J.L.M.; Folkerts, W.; Vries, de A.

    2015-01-01

    The SolarBEAT facility is an outdoor Research & Development infrastructure for innovation on BIPV(T). The facility is a cooperation between SEAC and the Technical University Eindhoven and is located in the Netherlands. It has been founded early 2014 and has grown rapidly to its full capacity at the

  8. A novel DC Magnetron sputtering facility for space research and synchrotron radiation optics

    DEFF Research Database (Denmark)

    Hussain, A.M.; Christensen, Finn Erland; Pareschi, G.

    1998-01-01

    A new DC magnetron sputtering facility has been build up at the Danish Space Research Institute (DSRI), specially designed to enable uniform coatings of large area curved optics, such as Wolter-I mirror optics used in space telescopes and curved optics used in synchrotron radiation facilities...

  9. Science facilities and stakeholder management: how a pan-European research facility ended up in a small Swedish university town

    Science.gov (United States)

    Thomasson, Anna; Carlile, Colin

    2017-06-01

    This is the story of how a large research facility of broad European and global interest, the European Spallation Source (ESS), ended up in the small university town of Lund in Sweden. This happened in spite of the fact that a number of influential European countries were at one time or another competitors to host the facility. It is also a story about politics which attempts to illustrate how closely intertwined politics and science are, and how the interplay between those interests affects scientific progress. ESS became an arena for individual ambitions and political manoeuvring. The different stakeholders, in their striving to ensure that their own interests were realised, in various ways and with different degrees of success over the years, have influenced the key decisions that, during the already 30 year history of ESS, have driven the course that this project has taken. What emerges is that the interests of the stakeholders and the interests of the project itself are frequently not in harmony. This imposes challenges on the management of large research facilities as they have to not only navigate in the scientific landscape, which they often are more familiar with, but also in the political landscape. This story is therefore an attempt to shed light on the role of managers of large research facilities and the often delicate balancing act they have to perform when trying to comply with the different and often conflicting stakeholder interests. What is especially worthwhile examining, as we do in this paper, is the role that individuals, and the interaction between individuals, have played in the process. This shows that the focus of stakeholder theory on organisations, rather than the people in the organisations, needs to be redirected on to the individuals representing those organisations and their inter-relationships. At the same time it is clear that the developing field of stakeholder management theory has not emerged into the consciousness of science

  10. Conceptual designs of near surface disposal facility for radioactive waste arising from the facilities using radioisotopes and research facilities for nuclear energy development and utilization

    International Nuclear Information System (INIS)

    Sakai, Akihiro; Yoshimori, Michiro; Okoshi, Minoru; Yamamoto, Tadatoshi; Abe, Masayoshi

    2001-03-01

    Various kinds of radioactive waste is generating from the utilization of radioisotopes in the field of science, technology, etc. and the utilization and development of nuclear energy. In order to promote the utilization of radionuclides and the research activities, it is necessary to treat and dispose of radioactive waste safely and economically. Japan Nuclear Cycle Development Institute (JNC), Japan Radioisotope Association (JRIA) and Japan Atomic Energy Research Institute (JAERI), which are the major waste generators in Japan in these fields, are promoting the technical investigations for treatment and disposal of the radioactive waste co-operately. Conceptual design of disposal facility is necessary to demonstrate the feasibility of waste disposal business and to determine the some conditions such as the area size of the disposal facility. Three institutes share the works to design disposal facility. Based on our research activities and experiences of waste disposal, JAERI implemented the designing of near surface disposal facilities, namely, simple earthen trench and concrete vaults. The designing was performed based on the following three assumed site conditions to cover the future site conditions: (1) Case 1 - Inland area with low groundwater level, (2) Case 2 - Inland area with high groundwater level, (3) Case 3 - Coastal area. The estimation of construction costs and the safety analysis were also performed based on the designing of facilities. The safety assessment results show that the safety for concrete vault type repository is ensured by adding low permeability soil layer, i.e. mixture of soil and bentonite, surrounding the vaults not depending on the site conditions. The safety assessment results for simple earthen trench also show that their safety is ensured not depending on the site conditions, if they are constructed above groundwater levels. The construction costs largely depend on the depth for excavation to build the repositories. (author)

  11. The IGNITE network: a model for genomic medicine implementation and research.

    Science.gov (United States)

    Weitzel, Kristin Wiisanen; Alexander, Madeline; Bernhardt, Barbara A; Calman, Neil; Carey, David J; Cavallari, Larisa H; Field, Julie R; Hauser, Diane; Junkins, Heather A; Levin, Phillip A; Levy, Kenneth; Madden, Ebony B; Manolio, Teri A; Odgis, Jacqueline; Orlando, Lori A; Pyeritz, Reed; Wu, R Ryanne; Shuldiner, Alan R; Bottinger, Erwin P; Denny, Joshua C; Dexter, Paul R; Flockhart, David A; Horowitz, Carol R; Johnson, Julie A; Kimmel, Stephen E; Levy, Mia A; Pollin, Toni I; Ginsburg, Geoffrey S

    2016-01-05

    Patients, clinicians, researchers and payers are seeking to understand the value of using genomic information (as reflected by genotyping, sequencing, family history or other data) to inform clinical decision-making. However, challenges exist to widespread clinical implementation of genomic medicine, a prerequisite for developing evidence of its real-world utility. To address these challenges, the National Institutes of Health-funded IGNITE (Implementing GeNomics In pracTicE; www.ignite-genomics.org ) Network, comprised of six projects and a coordinating center, was established in 2013 to support the development, investigation and dissemination of genomic medicine practice models that seamlessly integrate genomic data into the electronic health record and that deploy tools for point of care decision making. IGNITE site projects are aligned in their purpose of testing these models, but individual projects vary in scope and design, including exploring genetic markers for disease risk prediction and prevention, developing tools for using family history data, incorporating pharmacogenomic data into clinical care, refining disease diagnosis using sequence-based mutation discovery, and creating novel educational approaches. This paper describes the IGNITE Network and member projects, including network structure, collaborative initiatives, clinical decision support strategies, methods for return of genomic test results, and educational initiatives for patients and providers. Clinical and outcomes data from individual sites and network-wide projects are anticipated to begin being published over the next few years. The IGNITE Network is an innovative series of projects and pilot demonstrations aiming to enhance translation of validated actionable genomic information into clinical settings and develop and use measures of outcome in response to genome-based clinical interventions using a pragmatic framework to provide early data and proofs of concept on the utility of these

  12. Research at the BNL Tandem Van de Graaff Facility, 1980

    International Nuclear Information System (INIS)

    1981-01-01

    Research programs at the Brookhaven Van de Graaff accelerators are summarized. Major accomplishments of the laboratory are discussed including quasielastic reactions, high-spin spectroscopy, yrast spectra, fusion reactions, and atomic physics. The outside user program at the Laboratory is discussed. Research proposed for 1981 is outlined

  13. Ethical issues and best practice in clinically based genomic research: Exeter Stakeholders Meeting Report.

    Science.gov (United States)

    Carrieri, D; Bewshea, C; Walker, G; Ahmad, T; Bowen, W; Hall, A; Kelly, S

    2016-09-27

    Current guidelines on consenting individuals to participate in genomic research are diverse. This creates problems for participants and also for researchers, particularly for clinicians who provide both clinical care and research to their patients. A group of 14 stakeholders met on 7 October 2015 in Exeter to discuss the ethical issues and the best practice arising in clinically based genomic research, with particular emphasis on the issue of returning results to study participants/patients in light of research findings affecting research and clinical practices. The group was deliberately multidisciplinary to ensure that a diversity of views was represented. This report outlines the main ethical issues, areas of best practice and principles underlying ethical clinically based genomic research discussed during the meeting. The main point emerging from the discussion is that ethical principles, rather than being formulaic, should guide researchers/clinicians to identify who the main stakeholders are to consult with for a specific project and to incorporate their voices/views strategically throughout the lifecycle of each project. We believe that the mix of principles and practical guidelines outlined in this report can contribute to current debates on how to conduct ethical clinically based genomic research. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

  14. Research for the safety of existing nuclear facilities

    International Nuclear Information System (INIS)

    Teschendorff, Victor; Bruna, Giovanni B.; Gelder, Pieter de

    2007-01-01

    The essential role of research for maintaining the high safety standard for the existing nuclear installations is outlined in the context of internationally agreed needs. The three co-authoring Technical Safety Organisations are committed to continued safety research, recognising operational experience and new technologies as the main driving forces. The safety margin concept is introduced and new trends in traditional and new areas of safety research are identified. The importance of a sufficient experimental infrastructure and international co-operation in sustainable networks is highlighted. (orig.)

  15. Waste from decommissioning of research reactors and other small nuclear facilities

    International Nuclear Information System (INIS)

    Massaut, V.

    2001-01-01

    Full text: Small nuclear facilities were often built for research or pilot purposes. It includes the research reactors of various types and various aims (physics research, nuclear research, nuclear weapons development, materials testing reactor, isotope production, pilot plant, etc.) as well as laboratories, hot cells and accelerators used for a broad spectrum of research or production purposes. These installations are characterized not only by their size (reduced footprint) but also, and even mostly, by the very diversified type of materials, products and isotopes handled within these facilities. This large variety can sometimes enhance the difficulties encountered for the dismantling of such facilities. The presence of materials like beryllium, graphite, lead, PCBs, sodium, sometimes in relatively large quantities, are also challenges to be faced by the dismantlers of such facilities, because these types of waste are either toxic or no solutions are readily available for their conditioning or long term disposal. The paper will review what is currently done in different small nuclear facilities, and what are the remaining problems and challenges for future dismantling and waste management. The question of whether Research and Development for waste handling methods and processes is needed is still pending. Even for the dismantling operation itself, important improvements can be brought in the fields of characterization, decontamination, remote handling, etc. by further developments and innovative systems. The way of funding such facilities decommissioning will be reviewed as well as the very difficult cost estimation for such facilities, often one-of-a-kind. The aspects of radioprotection optimization (ALARA principle) and classical operators safety will also be highlighted, as well as the potential solutions or improvements. In fact, small nuclear facilities encounter often, when dismantling, the same problems as the large nuclear power plants, but have in

  16. Research Facilities for Solar Astronomy at ARIES P. Pant

    Indian Academy of Sciences (India)

    Aryabhatta Research Institute of Observational Sciences (ARIES), Manora Peak,. Nainital 263 129 .... station-20 computer, a GPS clock for accurate timing, etc. The various CCD ... circulation unit is used for cooling the camera head up to −25.

  17. A Design of Alarm System in a Research Reactor Facility

    International Nuclear Information System (INIS)

    Park, Jaekwan; Jang, Gwisook; Seo, Sangmun; Suh, Yongsuk

    2013-01-01

    The digital alarm system has become an indispensable design to process a large amount of alarms of power plants. Korean research reactor operated for decades maintains a hybrid alarm system with both an analog annunciator and a digital alarm display. In this design, several alarms are indicated on an analog panel and digital display, respectively, and it requires more attention and effort of the operators. As proven in power plants, a centralized alarm system design is necessary for a new research reactor. However, the number of alarms and operators in a research reactor is significantly lesser than power plants. Thus, simplification should be considered as an important factor for the operation efficiency. This paper introduces a simplified alarm system. As advances in information technology, fully digitalized alarm systems have been applied to power plants. In a new research reactor, it will be more useful than an analog or hybrid configuration installed in research reactors decades ago. However, the simplification feature should be considered as an important factor because the number of alarms and number of operators in a research reactor is significantly lesser than in power plants

  18. Research notes : drainage facility asset management : more than an inventory of pipes.

    Science.gov (United States)

    2007-04-01

    The primary objectives for the research project were twofold: 1) To develop and implement an Oregon-specific system for inventorying and evaluating the condition of pipes, culverts, and stormwater facilities based on the FHWA Culvert Management Syste...

  19. Safety Analysis Report: X17B2 beamline Synchrotron Medical Research Facility

    International Nuclear Information System (INIS)

    Gmuer, N.F.; Thomlinson, W.

    1990-02-01

    This report contains a safety analysis for the X17B2 beamline synchrotron medical research facility. Health hazards, risk assessment and building systems are discussed. Reference is made to transvenous coronary angiography

  20. Sub-scale Direct Connect Supersonic Combustion Facility (Research Cell 18)

    Data.gov (United States)

    Federal Laboratory Consortium — Description: RC18 is a continuous-flow, direct-connect, supersonic-combustion research facility that is capable of simulating flight conditions from Mach 3.0 to Mach...

  1. Atomic physics at the future facility for antiproton and ion research: a status report

    International Nuclear Information System (INIS)

    Gumberidze, A

    2013-01-01

    The new international accelerator Facility for Antiproton and Ion Research (FAIR) which is currently under construction in Darmstadt has key features that offer a wide range of exciting new opportunities in the field of atomic physics and related fields. The facility will provide highest intensities of relativistic beams of both stable and unstable heavy nuclei, in combination with the strong electromagnetic fields generated by high-power lasers, thus allowing to widen atomic physics research into completely new domains. In the current contribution, a short overview of the SPARC (Stored Particle Atomic physics Research Collaboration) research programme at the FAIR facility is given. Furthermore, we present the current strategy for the realization of the envisioned SPARC physics programme at the modularized start version of the FAIR facility. (paper)

  2. Archive of Geosample Information from the British Ocean Sediment Core Research Facility (BOSCORF)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The British Ocean Sediment Core Research Facility (BOSCORF), National Oceanography Centre, is a contributor to the Index to Marine and Lacustrine Geological Samples...

  3. Diffraction studies applicable to 60-foot microwave research facilities

    Science.gov (United States)

    Schmidt, R. F.

    1973-01-01

    The principal features of this document are the analysis of a large dual-reflector antenna system by vector Kirchhoff theory, the evaluation of subreflector aperture-blocking, determination of the diffraction and blockage effects of a subreflector mounting structure, and an estimate of strut-blockage effects. Most of the computations are for a frequency of 15.3 GHz, and were carried out using the IBM 360/91 and 360/95 systems at Goddard Space Flight Center. The FORTRAN 4 computer program used to perform the computations is of a general and modular type so that various system parameters such as frequency, eccentricity, diameter, focal-length, etc. can be varied at will. The parameters of the 60-foot NRL Ku-band installation at Waldorf, Maryland, were entered into the program for purposes of this report. Similar calculations could be performed for the NELC installation at La Posta, California, the NASA Wallops Station facility in Virginia, and other antenna systems, by a simple change in IBM control cards. A comparison is made between secondary radiation patterns of the NRL antenna measured by DOD Satellite and those obtained by analytical/numerical methods at a frequency of 7.3 GHz.

  4. Gas-gun facility for shock wave research at BARC

    International Nuclear Information System (INIS)

    Gupta, S.C.; Jyoti, G.; Suresh, N.; Sikka, S.K.; Chidambaram, R.; Agarwal, R.G.; Roy, S.; Kakodkar, A.

    1995-01-01

    For carrying out shock-wave experiments on materials, we have built a 63 mm diameter gas-gun facility at our laboratory. It is capable of accelerating projectiles (about half kg in weight) to velocities up to 1 km/s using N 2 and He gases. These on impacting a target generate shock pressures up to 40 GPa, depending upon the impedance of the impactor and the target. The barrel of the gun is slotted so that a keyed projectile can be fired for combined compression- shear studies. Large samples can be shocked (about 60 mm diameter and 5-10 mm thick), with pressures lasting for a few microseconds. The gun is similar in design to the one at Washington State University. A number of diagnostic techniques have also been developed. These include measurement of projectile velocity, tilt between the impactor and the target, shock velocity in the target, and time resolved in-material stress wave histories in the shock loaded samples. Recovery capsules have also been made to retrieve shocked samples on unloading, which are then analysed using microscopic techniques like x-ray diffraction, Raman and electron microscopy. The gun has been performing well and has already been used for a few phase transition studies. (author). 73 refs., 42 figs

  5. 76 FR 38399 - Assessing the Current Research, Policy, and Practice Environment in Public Health Genomics

    Science.gov (United States)

    2011-06-30

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention [Docket Number CDC-2011-0008] Assessing the Current Research, Policy, and Practice Environment in Public Health... information helpful to assess the current research, policy, and practice environment in public health genomics...

  6. A facility for using cluster research to study environmental problems. Workshop proceedings

    Energy Technology Data Exchange (ETDEWEB)

    1991-11-01

    This report begins by describing the general application of cluster based research to environmental chemistry and the development of a Cluster Structure and Dynamics Research Facility (CSDRF). Next, four important areas of cluster research are described in more detail, including how they can impact environmental problems. These are: surface-supported clusters, water and contaminant interactions, time-resolved dynamic studies in clusters, and cluster structures and reactions. These facilities and equipment required for each area of research are then presented. The appendices contain workshop agenda and a listing of the researchers who participated in the workshop discussions that led to this report.

  7. Safety research experiment facilities, Idaho National Engineering Laboratory, Idaho. Final environmental impact statement

    International Nuclear Information System (INIS)

    Liverman, J.L.

    1977-09-01

    This environmental statement was prepared for the Safety Research Experiment Facilities (SAREF) Project. The purpose of the proposed project is to modify some existing facilities and provide a new test facility at the Idaho National Engineering Laboratory (INEL) for conducting fast breeder reactor (FBR) safety experiments. The SAREF Project proposal has been developed after an extensive study which identified the FBR safety research needs requiring in-reactor experiments and which evaluated the capability of various existing and new facilities to meet these needs. The proposed facilities provide for the in-reactor testing of large bundles of prototypical FBR fuel elements under a wide variety of conditions, ranging from those abnormal operating conditions which might be expected to occur during the life of an FBR power plant to the extremely low probability, hypothetical accidents used in the evaluation of some design options and in the assessment of the long-term potential risk associated with wide-acale deployment of the FBR

  8. Report of the research results with joint-use facilities in fiscal year 1977

    International Nuclear Information System (INIS)

    1978-01-01

    In the Nuclear Engineering Research Laboratory, the University of Tokyo, fast neutron source reactor 'Yayoi', linac and fusion-reactor blanket facility are jointly used by educational institutions. Research results from the joint uses of the facilities in fiscal 1977 are presented in individual summaries: (on-pile) irradiation, reactor physics and engineering, etc., (off-pile) equipment and component techniques, etc., (linac) operation, etc., with these joint uses, unique works are intended in resonable way. (Mori, K.)

  9. Radiological Research Accelerator Facility. Progress report, April 1-November 30, 1986

    International Nuclear Information System (INIS)

    1986-07-01

    The Radiological Research Accelerator Facility (RARAF) is based on a 4-MV Van de Graaff accelerator, which is used to generate a variety of well-characterized radiation beams for research in radiobiology and radiological physics. The experiments run at RARAF are described, and center on neutron dosimetry, mutagenesis, and neutron-induced oncogenic transformations as well as survival of exposed cells. Accelerator utilization, operation, and development of facilities are reviewed

  10. The National Ignition Facility (NIF) and High Energy Density Science Research at LLNL (Briefing Charts)

    Science.gov (United States)

    2013-06-21

    The National Ignition Facility ( NIF ) and High Energy Density Science Research at LLNL Presentation to: IEEE Pulsed Power and Plasma Science...Conference C. J. Keane Director, NIF User Office June 21, 2013 1491978-1-4673-5168-3/13/$31.00 ©2013 IEEE Report Documentation Page Form ApprovedOMB No...4. TITLE AND SUBTITLE The National Ignition Facility ( NIF ) and High Energy Density Science Research at LLNL 5a. CONTRACT NUMBER 5b. GRANT

  11. Licensing review process of the European Spallation Source (ESS) research facility

    International Nuclear Information System (INIS)

    Brewitz, Erica

    2014-01-01

    On 3 January 2012 a license application under the Radiation Protection Act (SFS, 1988b) for the European Spallation Source research facility was submitted to the Swedish Radiation Safety Authority. The European Spallation Source research facility will be the site of a new and quite unusual kind of neutron source, based on a large proton accelerator that bombards a heavy material with protons. The Swedish Radiation Safety Authority is now reviewing the application. (authors)

  12. Secure web book to store structural genomics research data.

    Science.gov (United States)

    Manjasetty, Babu A; Höppner, Klaus; Mueller, Uwe; Heinemann, Udo

    2003-01-01

    Recently established collaborative structural genomics programs aim at significantly accelerating the crystal structure analysis of proteins. These large-scale projects require efficient data management systems to ensure seamless collaboration between different groups of scientists working towards the same goal. Within the Berlin-based Protein Structure Factory, the synchrotron X-ray data collection and the subsequent crystal structure analysis tasks are located at BESSY, a third-generation synchrotron source. To organize file-based communication and data transfer at the BESSY site of the Protein Structure Factory, we have developed the web-based BCLIMS, the BESSY Crystallography Laboratory Information Management System. BCLIMS is a relational data management system which is powered by MySQL as the database engine and Apache HTTP as the web server. The database interface routines are written in Python programing language. The software is freely available to academic users. Here we describe the storage, retrieval and manipulation of laboratory information, mainly pertaining to the synchrotron X-ray diffraction experiments and the subsequent protein structure analysis, using BCLIMS.

  13. Final report of the group research. Genome analysis on the biological effects of radiation. Second research group of NIRS

    International Nuclear Information System (INIS)

    2001-10-01

    This report concerns investigations on the title conducted by 5 subgroups of National Institute of Radiological Sciences (NIRS) during the period of 1993-2001. The report involves the organization of research teams and summary reports from the subgroups for Genome sequencing and informatics, Genome analysis on model organisms, The genome analysis on the specific chromosomal region related to radiation-sensitivity, Molecular analysis on the structure and function of particular regions of human genome, and Generation and characterization of DNA repair-deficient model mice. Significant results are as follows: Sequencing of the radiation sensitivity gene ATM, finding of a novel cell cycle regulator gene NPAT and regulation of gene expression of ATM/NPAT; Findings that the cause of the variability related to instability of human genome is derived from particular repeat structures of 5 and 35 bases and of the instability mutation, from the mutation of EPILS (mRNA synthase gene); Program development for novel human genome finding in the DNA sequences and making novel human gene as a resource by polymerase chain reaction (PCR) technique; and generation of the highly UV-sensitive mouse model for human xeroderma pigmentosum G. Conclusion is that findings will contribute for better understanding of the genes functioning radiation sensitivity and also biodefense mechanism against radiation and other environmental stress. (N.I.)

  14. Syrinx - a research program for the pulsed power radiation facility

    International Nuclear Information System (INIS)

    Etlicher, B.; Chuvatin, A.S.; Choi, P.

    1996-01-01

    Syrinx is a targeted research program with the objective to study, through practical examples, the fundamentals necessary to define the details of all parts which will be required for a new powerful plasma radiation source. The current level of activities of Syrinx is in the design and construction of a multi-megajoule class IES based pulsed power driver which will use long conduction Plasma Opening Switch technology. The present paper reviews mainly the basic experimental research of the POS a nd Z-pinch accomplished in the framework of Syrinx project. This work has a unique international level of participation, from conceptual designs to particular investigations. (author). 9 figs., 17 refs

  15. Genomic research and data-mining technology: implications for personal privacy and informed consent.

    Science.gov (United States)

    Tavani, Herman T

    2004-01-01

    This essay examines issues involving personal privacy and informed consent that arise at the intersection of information and communication technology (ICT) and population genomics research. I begin by briefly examining the ethical, legal, and social implications (ELSI) program requirements that were established to guide researchers working on the Human Genome Project (HGP). Next I consider a case illustration involving deCODE Genetics, a privately owned genetic company in Iceland, which raises some ethical concerns that are not clearly addressed in the current ELSI guidelines. The deCODE case also illustrates some ways in which an ICT technique known as data mining has both aided and posed special challenges for researchers working in the field of population genomics. On the one hand, data-mining tools have greatly assisted researchers in mapping the human genome and in identifying certain "disease genes" common in specific populations (which, in turn, has accelerated the process of finding cures for diseases tha affect those populations). On the other hand, this technology has significantly threatened the privacy of research subjects participating in population genomics studies, who may, unwittingly, contribute to the construction of new groups (based on arbitrary and non-obvious patterns and statistical correlations) that put those subjects at risk for discrimination and stigmatization. In the final section of this paper I examine some ways in which the use of data mining in the context of population genomics research poses a critical challenge for the principle of informed consent, which traditionally has played a central role in protecting the privacy interests of research subjects participating in epidemiological studies.

  16. A broadly implementable research course in phage discovery and genomics for first-year undergraduate students.

    Science.gov (United States)

    Jordan, Tuajuanda C; Burnett, Sandra H; Carson, Susan; Caruso, Steven M; Clase, Kari; DeJong, Randall J; Dennehy, John J; Denver, Dee R; Dunbar, David; Elgin, Sarah C R; Findley, Ann M; Gissendanner, Chris R; Golebiewska, Urszula P; Guild, Nancy; Hartzog, Grant A; Grillo, Wendy H; Hollowell, Gail P; Hughes, Lee E; Johnson, Allison; King, Rodney A; Lewis, Lynn O; Li, Wei; Rosenzweig, Frank; Rubin, Michael R; Saha, Margaret S; Sandoz, James; Shaffer, Christopher D; Taylor, Barbara; Temple, Louise; Vazquez, Edwin; Ware, Vassie C; Barker, Lucia P; Bradley, Kevin W; Jacobs-Sera, Deborah; Pope, Welkin H; Russell, Daniel A; Cresawn, Steven G; Lopatto, David; Bailey, Cheryl P; Hatfull, Graham F

    2014-02-04

    Engaging large numbers of undergraduates in authentic scientific discovery is desirable but difficult to achieve. We have developed a general model in which faculty and teaching assistants from diverse academic institutions are trained to teach a research course for first-year undergraduate students focused on bacteriophage discovery and genomics. The course is situated within a broader scientific context aimed at understanding viral diversity, such that faculty and students are collaborators with established researchers in the field. The Howard Hughes Medical Institute (HHMI) Science Education Alliance Phage Hunters Advancing Genomics and Evolutionary Science (SEA-PHAGES) course has been widely implemented and has been taken by over 4,800 students at 73 institutions. We show here that this alliance-sourced model not only substantially advances the field of phage genomics but also stimulates students' interest in science, positively influences academic achievement, and enhances persistence in science, technology, engineering, and mathematics (STEM) disciplines. Broad application of this model by integrating other research areas with large numbers of early-career undergraduate students has the potential to be transformative in science education and research training. Engagement of undergraduate students in scientific research at early stages in their careers presents an opportunity to excite students about science, technology, engineering, and mathematics (STEM) disciplines and promote continued interests in these areas. Many excellent course-based undergraduate research experiences have been developed, but scaling these to a broader impact with larger numbers of students is challenging. The Howard Hughes Medical Institute (HHMI) Science Education Alliance Phage Hunting Advancing Genomics and Evolutionary Science (SEA-PHAGES) program takes advantage of the huge size and diversity of the bacteriophage population to engage students in discovery of new viruses, genome

  17. Radiological Research Accelerator Facility. Progress report, April 1, 1984-March 31, 1985

    International Nuclear Information System (INIS)

    Rossi, H.H.

    1985-01-01

    The aim of the Radiological Research Accelerator Facility (RARAF) was to provide a source of monoenergetic neutrons for studies in radiation biology, dosimetry and microdosimetry. The research has provided insight into the biological action of radiation and its relation to energy distribution in the cell as described by the theory of dual radiation action. This status report on the facility includes descriptions of the capabilities and layout, staffing, radiation safety, and a chronological account of the development and use of the facilities. 5 references, 2 figures

  18. Los Alamos National Laboratory Weapons Neutron Research Facility

    International Nuclear Information System (INIS)

    Woods, R.

    1981-01-01

    The Weapons Neutron Research (WNR) spallation neutron source utilizes 800-MeV protons from the Los Alamos Meson Physics linac. The proton beam transport system, the target systems, and the data acquisition and control system are described. Operating experience, present status, and planned improvements are discussed

  19. The ethical use of existing samples for genome research.

    Science.gov (United States)

    Bathe, Oliver F; McGuire, Amy L

    2009-10-01

    Modern biobanking efforts consist of prospective collections of tissues linked to clinical data for patients who have given informed consent for the research use of their specimens and data, including their DNA. In such efforts, patient autonomy and privacy are well respected because of the prospective nature of the informed consent process. However, one of the richest sources of tissue for research continues to be the millions of archived samples collected by pathology departments during normal clinical care or for research purposes without specific consent for future research or genetic analysis. Because specific consent was not obtained a priori, issues related to individual privacy and autonomy are much more complicated. A framework for accessing these existing samples and related clinical data for research is presented. Archival tissues may be accessed only when there is a reasonable likelihood of generating beneficial and scientifically valid information. To minimize risks, databases containing information related to the tissue and to clinical data should be coded, no personally identifying phenotypic information should be included, and access should be restricted to bona fide researchers for legitimate research purposes. These precautions, if implemented appropriately, should ensure that the research use of archival tissue and data are no more than minimal risk. A waiver of the requirement for informed consent would then be justified if reconsent is shown to be impracticable. A waiver of consent should not be granted, however, if there is a significant risk to privacy, if the proposed research use is inconsistent with the original consent (where there is one), or if the potential harm from a privacy breach is considerable.

  20. The Design of HVAC System in the Conventional Facility of Proton Accelerator Research Center

    International Nuclear Information System (INIS)

    Jeon, G. P.; Kim, J. Y.; Choi, B. H.

    2007-01-01

    The HVAC systems for conventional facility of Proton Accelerator Research Center consist of 3 systems : accelerator building HVAC system, beam application building HVAC system and miscellaneous HVAC system. We designed accelerator building HVAC system and beam application research area HVAC system in the conventional facilities of Proton Accelerator research center. Accelerator building HVAC system is divided into accelerator tunnel area, klystron area, klystron gallery area, accelerator assembly area. Also, Beam application research area HVAC system is divided into those of beam experimental hall, accelerator control area, beam application research area and Ion beam application building. In this paper, We described system design requirements and explained system configuration for each systems. We presented operation scenario of HVAC system in the Conventional Facility of Proton Accelerator Research Center