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Sample records for genome project final

  1. Human Genome Teacher Networking Project, Final Report, April 1, 1992 - March 31, 1998

    Energy Technology Data Exchange (ETDEWEB)

    Collins, Debra

    1999-10-01

    Project to provide education regarding ethical legal and social implications of Human Genome Project to high school science teachers through two consecutive summer workshops, in class activities, and peer teaching workshops.

  2. The Human Genome Project: Information access, management, and regulation. Final report

    Energy Technology Data Exchange (ETDEWEB)

    McInerney, J.D.; Micikas, L.B.

    1996-08-31

    The Human Genome Project is a large, internationally coordinated effort in biological research directed at creating a detailed map of human DNA. This report describes the access of information, management, and regulation of the project. The project led to the development of an instructional module titled The Human Genome Project: Biology, Computers, and Privacy, designed for use in high school biology classes. The module consists of print materials and both Macintosh and Windows versions of related computer software-Appendix A contains a copy of the print materials and discs containing the two versions of the software.

  3. The Human Genome Project and Mental Retardation: An Educational Program. Final Progress Report

    Energy Technology Data Exchange (ETDEWEB)

    Davis, Sharon

    1999-05-03

    The Arc, a national organization on mental retardation, conducted an educational program for members, many of whom have a family member with a genetic condition causing mental retardation. The project informed members about the Human Genome scientific efforts, conducted training regarding ethical, legal and social implications and involved members in issue discussions. Short reports and fact sheets on genetic and ELSI topics were disseminated to 2,200 of the Arc's leaders across the country and to other interested individuals. Materials produced by the project can e found on the Arc's web site, TheArc.org.

  4. The human genome project

    International Nuclear Information System (INIS)

    Worton, R.

    1996-01-01

    The Human Genome Project is a massive international research project, costing 3 to 5 billion dollars and expected to take 15 years, which will identify the all the genes in the human genome - i.e. the complete sequence of bases in human DNA. The prize will be the ability to identify genes causing or predisposing to disease, and in some cases the development of gene therapy, but this new knowledge will raise important ethical issues

  5. Human Genome Project

    Energy Technology Data Exchange (ETDEWEB)

    Block, S. [The MITRE Corporation, McLean, VA (US). JASON Program Office; Cornwall, J. [The MITRE Corporation, McLean, VA (US). JASON Program Office; Dally, W. [The MITRE Corporation, McLean, VA (US). JASON Program Office; Dyson, F. [The MITRE Corporation, McLean, VA (US). JASON Program Office; Fortson, N. [The MITRE Corporation, McLean, VA (US). JASON Program Office; Joyce, G. [The MITRE Corporation, McLean, VA (US). JASON Program Office; Kimble, H. J. [The MITRE Corporation, McLean, VA (US). JASON Program Office; Lewis, N. [The MITRE Corporation, McLean, VA (US). JASON Program Office; Max, C. [The MITRE Corporation, McLean, VA (US). JASON Program Office; Prince, T. [The MITRE Corporation, McLean, VA (US). JASON Program Office; Schwitters, R. [The MITRE Corporation, McLean, VA (US). JASON Program Office; Weinberger, P. [The MITRE Corporation, McLean, VA (US). JASON Program Office; Woodin, W. H. [The MITRE Corporation, McLean, VA (US). JASON Program Office

    1998-01-04

    The study reviews Department of Energy supported aspects of the United States Human Genome Project, the joint National Institutes of Health/Department of Energy program to characterize all human genetic material, to discover the set of human genes, and to render them accessible for further biological study. The study concentrates on issues of technology, quality assurance/control, and informatics relevant to current effort on the genome project and needs beyond it. Recommendations are presented on areas of the genome program that are of particular interest to and supported by the Department of Energy.

  6. RadGenomics project

    Energy Technology Data Exchange (ETDEWEB)

    Iwakawa, Mayumi; Imai, Takashi; Harada, Yoshinobu [National Inst. of Radiological Sciences, Chiba (Japan). Frontier Research Center] [and others

    2002-06-01

    Human health is determined by a complex interplay of factors, predominantly between genetic susceptibility, environmental conditions and aging. The ultimate aim of the RadGenomics (Radiation Genomics) project is to understand the implications of heterogeneity in responses to ionizing radiation arising from genetic variation between individuals in the human population. The rapid progression of the human genome sequencing and the recent development of new technologies in molecular genetics are providing us with new opportunities to understand the genetic basis of individual differences in susceptibility to natural and/or artificial environmental factors, including radiation exposure. The RadGenomics project will inevitably lead to improved protocols for personalized radiotherapy and reductions in the potential side effects of such treatment. The project will contribute to future research into the molecular mechanisms of radiation sensitivity in humans and will stimulate the development of new high-throughput technologies for a broader application of biological and medical sciences. The staff members are specialists in a variety of fields, including genome science, radiation biology, medical science, molecular biology, and informatics, and have joined the RadGenomics project from various universities, companies, and research institutes. The project started in April 2001. (author)

  7. RadGenomics project

    International Nuclear Information System (INIS)

    Iwakawa, Mayumi; Imai, Takashi; Harada, Yoshinobu

    2002-01-01

    Human health is determined by a complex interplay of factors, predominantly between genetic susceptibility, environmental conditions and aging. The ultimate aim of the RadGenomics (Radiation Genomics) project is to understand the implications of heterogeneity in responses to ionizing radiation arising from genetic variation between individuals in the human population. The rapid progression of the human genome sequencing and the recent development of new technologies in molecular genetics are providing us with new opportunities to understand the genetic basis of individual differences in susceptibility to natural and/or artificial environmental factors, including radiation exposure. The RadGenomics project will inevitably lead to improved protocols for personalized radiotherapy and reductions in the potential side effects of such treatment. The project will contribute to future research into the molecular mechanisms of radiation sensitivity in humans and will stimulate the development of new high-throughput technologies for a broader application of biological and medical sciences. The staff members are specialists in a variety of fields, including genome science, radiation biology, medical science, molecular biology, and informatics, and have joined the RadGenomics project from various universities, companies, and research institutes. The project started in April 2001. (author)

  8. Final project report

    Energy Technology Data Exchange (ETDEWEB)

    Nitin S. Baliga and Leroy Hood

    2008-11-12

    The proposed overarching goal for this project was the following: Data integration, simulation and visualization will facilitate metabolic and regulatory network prediction, exploration, and formulation of hypotheses. We stated three specific aims to achieve the overarching goal of this project: (1) Integration of multiple levels of information such as mRNA and protein levels, predicted protein-protein interactions/associations and gene function will enable construction of models describing environmental response and dynamic behavior. (2) Flexible tools for network inference will accelerate our understanding of biological systems. (3) Flexible exploration and queries of model hypotheses will provide focus and reveal novel dependencies. The underlying philosophy of these proposed aims is that an iterative cycle of experiments, experimental design, and verification will lead to a comprehensive and predictive model that will shed light on systems level mechanisms involved in responses elicited by living systems upon sensing a change in their environment. In the previous years report we demonstrated considerable progress in development of data standards, regulatory network inference and data visualization and exploration. We are pleased to report that several manuscripts describing these procedures have been published in top international peer reviewed journals including Genome Biology, PNAS, and Cell. The abstracts of these manuscripts are given and they summarize our accomplishments in this project.

  9. The Ensembl genome database project.

    Science.gov (United States)

    Hubbard, T; Barker, D; Birney, E; Cameron, G; Chen, Y; Clark, L; Cox, T; Cuff, J; Curwen, V; Down, T; Durbin, R; Eyras, E; Gilbert, J; Hammond, M; Huminiecki, L; Kasprzyk, A; Lehvaslaiho, H; Lijnzaad, P; Melsopp, C; Mongin, E; Pettett, R; Pocock, M; Potter, S; Rust, A; Schmidt, E; Searle, S; Slater, G; Smith, J; Spooner, W; Stabenau, A; Stalker, J; Stupka, E; Ureta-Vidal, A; Vastrik, I; Clamp, M

    2002-01-01

    The Ensembl (http://www.ensembl.org/) database project provides a bioinformatics framework to organise biology around the sequences of large genomes. It is a comprehensive source of stable automatic annotation of the human genome sequence, with confirmed gene predictions that have been integrated with external data sources, and is available as either an interactive web site or as flat files. It is also an open source software engineering project to develop a portable system able to handle very large genomes and associated requirements from sequence analysis to data storage and visualisation. The Ensembl site is one of the leading sources of human genome sequence annotation and provided much of the analysis for publication by the international human genome project of the draft genome. The Ensembl system is being installed around the world in both companies and academic sites on machines ranging from supercomputers to laptops.

  10. Controlling our destinies: Historical, philosophical, social and ethical perspectives on the Human Genome Project: Final report, July 1, 1995-June 30, 1996

    Energy Technology Data Exchange (ETDEWEB)

    Sloan, P.R.

    1996-09-25

    This report briefly describes the efforts by the organizing committee in preparation for the conference entitled Controlling Our Destinies: Historical, Philosophical, Social, and Ethical Perspectives on the Human Genome Project. The conference was held October 5-8, 1995.

  11. Origins of the Human Genome Project.

    Science.gov (United States)

    Watson, J D; Cook-Deegan, R M

    1991-01-01

    The Human Genome Project has become a reality. Building on a debate that dates back to 1985, several genome projects are now in full stride around the world, and more are likely to form in the next several years. Italy began its genome program in 1987, and the United Kingdom and U.S.S.R. in 1988. The European communities mounted several genome projects on yeast, bacteria, Drosophila, and Arabidospis thaliana (a rapidly growing plant with a small genome) in 1988, and in 1990 commenced a new 2-year program on the human genome. In the United States, we have completed the first year of operation of the National Center for Human Genome Research at the National Institutes of Health (NIH), now the largest single funding source for genome research in the world. There have been dedicated budgets focused on genome-scale research at NIH, the U.S. Department of Energy, and the Howard Hughes Medical Institute for several years, and results are beginning to accumulate. There were three annual meetings on genome mapping and sequencing at Cold Spring Harbor, New York, in the spring of 1988, 1989, and 1990; the talks have shifted from a discussion about how to approach problems to presenting results from experiments already performed. We have finally begun to work rather than merely talk. The purpose of genome projects is to assemble data on the structure of DNA in human chromosomes and those of other organisms. A second goal is to develop new technologies to perform mapping and sequencing. There have been impressive technical advances in the past 5 years since the debate about the human genome project began. We are on the verge of beginning pilot projects to test several approaches to sequencing long stretches of DNA, using both automation and manual methods. Ordered sets of yeast artificial chromosome and cosmid clones have been assembled to span more than 2 million base pairs of several human chromosomes, and a region of 10 million base pairs has been assembled for

  12. Final Project Report

    DEFF Research Database (Denmark)

    Duer, Karsten

    1997-01-01

    The report summarizes the work that has been carried out within the project "B1 AEROGELS" as a part of the IEA SH&CP Task 18 "Advanced Glazing and Associated Materials For SolarAnd Building Applications". By providing at the same time thermal insulation and transparency the silica aerogel is a very...

  13. Final Year Project Report

    Energy Technology Data Exchange (ETDEWEB)

    Hubsch, Tristan [Howard University

    2013-06-20

    In the last years of this eighteen-year grant project, the research efforts have focused mostly on the study of off-shell representations of supersymmetry, both on the worldline and on the world- sheet, i.e., both in supersymmetric quantum mechanics and in supersymmetric field theory in 1+1-dimensional spacetime.

  14. ACCESS Project: Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Weller, Heiko [Robert Bosch, LLC, Farmington Hills, MI (United States)

    2015-04-01

    The ACCESS project addressed the development, testing, and demonstration of the proposed advanced technologies and the associated emission and fuel economy improvement at an engine dynamometer and on a full-scale vehicle. Improve fuel economy by 25% with minimum performance penalties Achieve SULEV level emissions with gasoline Demonstrate multi-mode combustion engine management system

  15. Final Project Report

    Energy Technology Data Exchange (ETDEWEB)

    Small, R. Justin [Woods Hole Oceanographic Institution, MA (United States); Bryan, Frank [Woods Hole Oceanographic Institution, MA (United States); Tribbia, Joseph [Woods Hole Oceanographic Institution, MA (United States); Park, Sungsu [Woods Hole Oceanographic Institution, MA (United States); Dennis, John [Woods Hole Oceanographic Institution, MA (United States); Saravanan, R. [Woods Hole Oceanographic Institution, MA (United States); Schneider, Niklas [Woods Hole Oceanographic Institution, MA (United States); Kwon, Young-Oh [Woods Hole Oceanographic Institution, MA (United States)

    2015-06-01

    Most climate models are currently run with grid spacings of around 100km, which, with today’s computing power, allows for long (up to 1000 year) simulations, or ensembles of simulations to explore climate change and variability. However this grid spacing does not resolve important components of the weather/climate system such as atmospheric fronts and mesoscale systems, and ocean boundary currents and eddies. The overall aim of this project has been to look at the effect of these small-scale features on the weather/climate system using a suite of high and low resolution climate models, idealized models and observations. This project was only possible due to the highly scalable aspect of the CAM Spectral Element dynamical core, and the significant resources allocated at Yellowstone and NERSC for which we are grateful.

  16. Final Project Report

    DEFF Research Database (Denmark)

    Workspace

    2003-01-01

    of the Disappearing Computer to be that of  “Augmenting reality”, where “Augmented reality” meant:  •  Augmented user – positioning, visualising. •  Augmented environment, Panels, tables and site-pack •  Augmented Artifacts - RFID , tagging, tracking •  Augmented communications – efficient exchange and integration......The primary focus of the WORKSPACE project was to augment the working  environment through the development of spatial computing components, initially for  members of the design professions, but with wider applicability to a range of work  domains.     The project interpreted the requirements...... of the above.    The philosophy was to make the computer disappear by both making it large and  embedding it into the environment (e.g. furniture).  The project has successfully achieved its objectives, and has developed a range of  demonstrator prototypes, some of which is in daily use by practitioners within...

  17. Novalignin project. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Stigsson, Lars [KIRAM AB, Saltsjoebaden (Sweden)

    2002-02-01

    The NovaFiber process is a new and sustainable technology for manufacturing of chemical pulp incorporating an efficient route for recovery of energy and pulping chemicals. The process is substantially sulphur chemicals free and this creates a great potential for recovery of sulphur free lignin for internal use as a fuel or export from the mill. The NovaLignin project has been launched to evaluate this potential from a technical and economical perspective. The NovaLignin research and development effort has been partly financed by NUTEK, Energimyndigheten and Mistra. A major feature of the new lignin is the absence of organically bound sulphur compounds in the material increasing the scope of potential uses for the lignin as a precursor for fine chemicals preparation or as a sulphur free biomass based fuel. Two major forest industry laboratories in Scandinavia have conducted the laboratory cooking and lignin extraction work in the present project. The lignin extracted from the NovaFiber process, NovaLignin, has been characterised and evaluated for use in different applications. The consequences of lignin extraction in different mill configurations with a recovery boiler or a black liquor gasification system for chemicals recovery is outlined below. The NovaFiber pulp mill is compared to a reference mill based on conventional kraft pulping on the same wood raw material. The mill capacity is 2000 t/d bleached softwood pulp. The lime kiln is fired with bark and the remaining falling bark is sold, or if there is a deficit, more bark is purchased. Initial laboratory studies conducted at ATO-DLO, the Netherlands, clearly show a great potential for NovaLignin as a functional additive in thermoplastics. NovaFiber and Kraft lignin act as an UV stabiliser for polyethylene at a comparable level as an expensive commercial stabiliser, such as HALS. This means that NovaFiber lignin has a very good price/performance ratio. Experiments show that NovaFiber lignin has good potential

  18. Project radon final report

    International Nuclear Information System (INIS)

    Ekholm, S.; Rossby, U.

    1990-01-01

    The main radiation problem in Sweden is due to radon in dwellings. At the Swedish State Power Board, R, D and D about radon has been going on since 1980. The work has concentrated on the important questions: How to find building with enhanced radon levels?; How to accurately decide on measures that will give adequate cleaning-up results, using appropriate measurement procedures; What cleaning-up effect is possible to achieve with an electro-filter?; and What cleaning-up effects are possible to achieve with different types of ventilation systems? The R, D and D-work, has been pursued in cooperation with universities of technology in Denmark and Finland, equipment manufacturers, consultants and authorities concerned. It was decided in December 1986 to give an offer to some SSPB-employees to investigate the radon situation of their dwellings, in order to test methods of measurement and cleaning-up under realistic conditions and to develop the methods to commercial maturity. The investigation was named 'Project Radon' and was carried out in three years with costs amounting to 1 M dollars. During the project less comprehensive radon measurements, named 'trace-measurements' were undertaken in about 1300 dwellings and more elaborate measurements, leading to suggestions of actions to be taken, in about 400 dwellings. Out of the suggestions, about 50 are carried out including control measurement after actions taken. The control measurement have shown that the ability to suggest appropriate actions is very successful - in just one case was a minor additional action necessary. The high reliability is achieved by always doing elaborate measurements before suggested mitigation method is decided on. (authors)

  19. IRRSUD Project - Final report

    CERN Document Server

    Loyer, F

    2002-01-01

    IRRSUD is an irradiation facility which makes use of the low energy (0.5 MeV/n - 1 MeV/n) beams from the GANIL IRRSUD injectors. It is financed by the group GARI (Group of Ion Research Applications) and was established as a joint-venture of GANIL and CIRIL to develop the applied physics and ion based industrial applications. Among research directions framed by IRRSUD one can mention; the nano-technologies i.e. utilisation of the modifications induced in materials exposed to ion bombardment; realization of microporous membranes and low-D materials; aging of materials by irradiation. Also, the low energy ions issued from the injector matches very well the fission fragments in reactors. In addition IRRSUD could be used as testing facility for injectors.. The report is structured as follows: 1. Outline; 1.2. Project's main features; 1.3. Ion beam characterization; 2. Technical solutions; 2.1. Denominations; 2.2. Beam optics; 2.3. Beam bending magnets; 2.4. Beam instrumentation; 2.5. Current supply; 2.6. Vacuum sy...

  20. Final Project Report

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Jin [University of California Santa Cruz; Zhao, Yiping [University of Georgia at Athens

    2014-12-05

    In this entire project period from 2005-2014, we have made significant progress in developing novel nanostructures of metal oxides (MOs) for solar hydrogen generation based on photoelectrochemical (PEC). Materials investigated are focused on 1D and 0D MO nanostructures of TiO2, WO3, ZnO, and Fe2O3 in conjunction with quantum dot (QD) sensitization and chemical doping (N or H) to alter their electronic band structures for both visible light absorption and for facilitating interfacial charge transport. In addition, we have used plasmonic metal nanostructures to enhance the PEC performance by improving light absorption of QDs via enhanced scattering of the plamonic metal. Most importantly, we have discovered a multipronged strategy for improving PEC performance: using plasmonic metal nanostructure to enhance light absorption, QDs to improve charge transfer, and chemical doping to increase charge transport in metal oxides for PEC. The combination is critical for overall high efficiency of PEC. This strategy is developed and demonstrated for the first time to our best knowledge.

  1. The Pediatric Cancer Genome Project

    Science.gov (United States)

    Downing, James R; Wilson, Richard K; Zhang, Jinghui; Mardis, Elaine R; Pui, Ching-Hon; Ding, Li; Ley, Timothy J; Evans, William E

    2013-01-01

    The St. Jude Children’s Research Hospital–Washington University Pediatric Cancer Genome Project (PCGP) is participating in the international effort to identify somatic mutations that drive cancer. These cancer genome sequencing efforts will not only yield an unparalleled view of the altered signaling pathways in cancer but should also identify new targets against which novel therapeutics can be developed. Although these projects are still deep in the phase of generating primary DNA sequence data, important results are emerging and valuable community resources are being generated that should catalyze future cancer research. We describe here the rationale for conducting the PCGP, present some of the early results of this project and discuss the major lessons learned and how these will affect the application of genomic sequencing in the clinic. PMID:22641210

  2. The 1000 bull genome project

    Science.gov (United States)

    To meet growing global demands for high value protein from milk and meat, rates of genetic gain in domestic cattle must be accelerated. At the same time, animal health and welfare must be considered. The 1000 bull genomes project supports these goals by providing annotated sequence variants and ge...

  3. The Human Genome Diversity Project

    Energy Technology Data Exchange (ETDEWEB)

    Cavalli-Sforza, L. [Stanford Univ., CA (United States)

    1994-12-31

    The Human Genome Diversity Project (HGD Project) is an international anthropology project that seeks to study the genetic richness of the entire human species. This kind of genetic information can add a unique thread to the tapestry knowledge of humanity. Culture, environment, history, and other factors are often more important, but humanity`s genetic heritage, when analyzed with recent technology, brings another type of evidence for understanding species` past and present. The Project will deepen the understanding of this genetic richness and show both humanity`s diversity and its deep and underlying unity. The HGD Project is still largely in its planning stages, seeking the best ways to reach its goals. The continuing discussions of the Project, throughout the world, should improve the plans for the Project and their implementation. The Project is as global as humanity itself; its implementation will require the kinds of partnerships among different nations and cultures that make the involvement of UNESCO and other international organizations particularly appropriate. The author will briefly discuss the Project`s history, describe the Project, set out the core principles of the Project, and demonstrate how the Project will help combat the scourge of racism.

  4. All about the Human Genome Project (HGP)

    Science.gov (United States)

    ... Care Genomic Medicine Working Group New Horizons and Research Patient Management Policy and Ethics Issues Quick Links for Patient Care Education All About the Human Genome Project Fact Sheets Genetic Education Resources for ...

  5. Social implications of the Human Genome Project: Policy roundtable series and journals. Final progress report, March 15, 2001 - March 15, 2002

    Energy Technology Data Exchange (ETDEWEB)

    Seiguer, Erica

    2002-12-30

    This report reflects the activities of the Harvard Health Caucus at Harvard Medical School that were supported, in part, by the Department of Energy. The following policy roundtables and panels were held: Spring 2001 Policy Roundtable Series: The social implications of the Human Genome Project; Spring 2002 Policy Roundtable Series: Managing globalization to improve health; 13 February 2002 Keynote Address: The globalization of health; 25 February 2002 Healthier or Wealthier: Which comes first in the new global era?; 28 February 2002 The crisis of neglected diseases: Creating R&D incentives for diseases of developing countries; 7 March 2002 Health care education in the developing world: Bridging global and local health care practices; 20 March 2002 Building a legal framework for global health: How can the US and UN work to reduce global disparities?; 25 April 2002 The role of mass media and tobacco control efforts. Caucus organizational information is also included.

  6. The human genome: Some assembly required. Final report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1994-12-31

    The Human Genome Project promises to be one of the most rewarding endeavors in modern biology. The cost and the ethical and social implications, however, have made this project the source of considerable debate both in the scientific community and in the public at large. The 1994 Graduate Student Symposium addresses the scientific merits of the project, the technical issues involved in accomplishing the task, as well as the medical and social issues which stem from the wealth of knowledge which the Human Genome Project will help create. To this end, speakers were brought together who represent the diverse areas of expertise characteristic of this multidisciplinary project. The keynote speaker addresses the project`s motivations and goals in the larger context of biological and medical sciences. The first two sessions address relevant technical issues, data collection with a focus on high-throughput sequencing methods and data analysis with an emphasis on identification of coding sequences. The third session explores recent advances in the understanding of genetic diseases and possible routes to treatment. Finally, the last session addresses some of the ethical, social and legal issues which will undoubtedly arise from having a detailed knowledge of the human genome.

  7. Parasite Genome Projects and the Trypanosoma cruzi Genome Initiative

    Directory of Open Access Journals (Sweden)

    Wim Degrave

    1997-11-01

    Full Text Available Since the start of the human genome project, a great number of genome projects on other "model" organism have been initiated, some of them already completed. Several initiatives have also been started on parasite genomes, mainly through support from WHO/TDR, involving North-South and South-South collaborations, and great hopes are vested in that these initiatives will lead to new tools for disease control and prevention, as well as to the establishment of genomic research technology in developing countries. The Trypanosoma cruzi genome project, using the clone CL-Brener as starting point, has made considerable progress through the concerted action of more than 20 laboratories, most of them in the South. A brief overview of the current state of the project is given

  8. Genomics and the human genome project: implications for psychiatry

    OpenAIRE

    Kelsoe, J R

    2004-01-01

    In the past decade the Human Genome Project has made extraordinary strides in understanding of fundamental human genetics. The complete human genetic sequence has been determined, and the chromosomal location of almost all human genes identified. Presently, a large international consortium, the HapMap Project, is working to identify a large portion of genetic variation in different human populations and the structure and relationship of these variants to each other. The Human Genome Project h...

  9. The Chlamydomonas genome project: a decade on

    Science.gov (United States)

    Blaby, Ian K.; Blaby-Haas, Crysten; Tourasse, Nicolas; Hom, Erik F. Y.; Lopez, David; Aksoy, Munevver; Grossman, Arthur; Umen, James; Dutcher, Susan; Porter, Mary; King, Stephen; Witman, George; Stanke, Mario; Harris, Elizabeth H.; Goodstein, David; Grimwood, Jane; Schmutz, Jeremy; Vallon, Olivier; Merchant, Sabeeha S.; Prochnik, Simon

    2014-01-01

    The green alga Chlamydomonas reinhardtii is a popular unicellular organism for studying photosynthesis, cilia biogenesis and micronutrient homeostasis. Ten years since its genome project was initiated, an iterative process of improvements to the genome and gene predictions has propelled this organism to the forefront of the “omics” era. Housed at Phytozome, the Joint Genome Institute’s (JGI) plant genomics portal, the most up-to-date genomic data include a genome arranged on chromosomes and high-quality gene models with alternative splice forms supported by an abundance of RNA-Seq data. Here, we present the past, present and future of Chlamydomonas genomics. Specifically, we detail progress on genome assembly and gene model refinement, discuss resources for gene annotations, functional predictions and locus ID mapping between versions and, importantly, outline a standardized framework for naming genes. PMID:24950814

  10. Poplar Interactome: Project Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Jaiswal, Pankaj [Oregon State Univ., Corvallis, OR (United States)

    2018-03-21

    The feedstock plant Poplar has many advantages over traditional crop plants. Not only Poplar needs low energy input and off season storage as compared to feedstocks such as corn, in the winter season Poplar biomass is stored on the stem/trunk, and Poplar plantations serve as large carbon sink. A key constraint to the expansion of cellulosic bioenergy sources such as in Poplar however, is the negative consequence of converting land use from food crops to energy crops. Therefore in order for Poplar to become a viable energy crop it needs to be grown mostly on marginal land unsuitable agricultural crops. For this we need a better understanding of abiotic stress and adaptation response in poplar. In the process we expected to find new and existing poplar genes and their function that respond to sustain abiotic stress. We carried out an extensive gene expression study on the control untreated and stress (drought, salinity, cold and heat) treated poplar plants. The samples were collected from the stem, leaf and root tissues. The RNA of protein coding genes and regulatory smallRNA genes were sequenced generating more than a billion reads. This is the first such known study in Poplar plants. These were used for quantification and genomic analysis to identify stress responsive genes in poplar. Based on the quantification and genomic analysis, a select set of genes were studied for gene-gene interactions to find their association to stress response. The data was also used to find novel stress responsive genes in poplar that were previously not identified in the Poplar reference genome. The data is made available to the public through the national and international genomic data archives.

  11. Final Project Report for Award ER65581

    Energy Technology Data Exchange (ETDEWEB)

    Stoy, Paul C. [Montana State Univ., Bozeman, MT (United States)

    2017-07-13

    The attached final project report describes contributions of Montana State University (MSU) to the project "Bridging land-surface fluxes and aerosol concentrations to triggering convective rainfall" (PI: Fuentes).

  12. Helminth genome projects: all or nothing

    Czech Academy of Sciences Publication Activity Database

    Lukeš, Julius; Horák, Aleš; Scholz, Tomáš

    2005-01-01

    Roč. 21, č. 6 (2005), s. 265-266 ISSN 1471-4922 Institutional research plan: CEZ:AV0Z60220518 Keywords : genome project * helminth * Dracunculus Subject RIV: EG - Zoology Impact factor: 4.526, year: 2005

  13. The life cycle of a genome project: perspectives and guidelines inspired by insect genome projects.

    Science.gov (United States)

    Papanicolaou, Alexie

    2016-01-01

    Many research programs on non-model species biology have been empowered by genomics. In turn, genomics is underpinned by a reference sequence and ancillary information created by so-called "genome projects". The most reliable genome projects are the ones created as part of an active research program and designed to address specific questions but their life extends past publication. In this opinion paper I outline four key insights that have facilitated maintaining genomic communities: the key role of computational capability, the iterative process of building genomic resources, the value of community participation and the importance of manual curation. Taken together, these ideas can and do ensure the longevity of genome projects and the growing non-model species community can use them to focus a discussion with regards to its future genomic infrastructure.

  14. A decade of human genome project conclusion: Scientific diffusion about our genome knowledge.

    Science.gov (United States)

    Moraes, Fernanda; Góes, Andréa

    2016-05-06

    The Human Genome Project (HGP) was initiated in 1990 and completed in 2003. It aimed to sequence the whole human genome. Although it represented an advance in understanding the human genome and its complexity, many questions remained unanswered. Other projects were launched in order to unravel the mysteries of our genome, including the ENCyclopedia of DNA Elements (ENCODE). This review aims to analyze the evolution of scientific knowledge related to both the HGP and ENCODE projects. Data were retrieved from scientific articles published in 1990-2014, a period comprising the development and the 10 years following the HGP completion. The fact that only 20,000 genes are protein and RNA-coding is one of the most striking HGP results. A new concept about the organization of genome arose. The ENCODE project was initiated in 2003 and targeted to map the functional elements of the human genome. This project revealed that the human genome is pervasively transcribed. Therefore, it was determined that a large part of the non-protein coding regions are functional. Finally, a more sophisticated view of chromatin structure emerged. The mechanistic functioning of the genome has been redrafted, revealing a much more complex picture. Besides, a gene-centric conception of the organism has to be reviewed. A number of criticisms have emerged against the ENCODE project approaches, raising the question of whether non-conserved but biochemically active regions are truly functional. Thus, HGP and ENCODE projects accomplished a great map of the human genome, but the data generated still requires further in depth analysis. © 2016 by The International Union of Biochemistry and Molecular Biology, 44:215-223, 2016. © 2016 The International Union of Biochemistry and Molecular Biology.

  15. Attitudes towards the Human Genome Project.

    Science.gov (United States)

    Shahroudi, Julie; Shaw, Geraldine

    Attitudes concerning the Human Genome Project were reported by faculty (N=40) and students (N=66) from a liberal arts college. Positive attitudes toward the project involved privacy, insurance and health, economic purposes, reproductive purposes, genetic counseling, religion and overall opinions. Negative attitudes were expressed regarding…

  16. UMTRA project: Canonsburg final design

    International Nuclear Information System (INIS)

    Thiers, G.R.; Guros, F.B.; Smith, E.S.

    1984-01-01

    Final design for on-site stabilization of over 300,000 cubic yards of abandoned mill tailings in Canonsburg, Pennsylvania, is being completed this Fall. This paper describes design criteria, design procedures, and difficulties encountered for the following required elements: 1. Encapsulation cell; 2. Durability of erosion protection material; 3. Flood control berm; 4. Sedimentation pond; 5. Wastewater treatment plant. The 70,000 cubic yards of the tailings for which radiation levels exceed 100 picocuries per gram will be placed on a 2-ft-thick compacted clay liner and encased by a 3-ft-thick compacted clay cover. The remaining tailings will be covered with at least two feet of clay to prevent radon escape and to reduce rainfall infiltration. Erosion protection will be provided for the encapsulation cell, the drainage swales, and from potential meandering of nearby Chartiers Creek

  17. Photovoltaic demonstration project. Final report

    International Nuclear Information System (INIS)

    Jicarilla Apache Tribe

    2002-01-01

    The Jicarilla Apache Nation is in Rio Arriba County in North Central New Mexico. The photovoltaic project was installed at the Dulce High School in the town of Dulce. Dulce is in the most northern part of the reservation near the New Mexico/Colorado boundary and can be reached from the New Mexico State Capitol in Santa Fe, hence to the town of Chama along U.S. Highway 84 to the junction of U.S. Highway 64. Dulce is about 12 miles west of the junction along U.S. Highway 64. Dulce community is in the mountainous part of the Nation with a population of about 4000. No industry exists in the community, however, a few commercial sites do exist such as a motel, restaurants, gas stations, food and liquor stores

  18. Spray casting project final report

    International Nuclear Information System (INIS)

    Churnetski, S.R.; Thompson, J.E.

    1996-08-01

    Lockheed Martin Energy Systems, Inc. (Energy Systems), along with other participating organizations, has been exploring the feasibility of spray casting depleted uranium (DU) to near-net shape as a waste minimization effort. Although this technology would be useful in a variety of applications where DU was the material of choice, this effort was aimed primarily at gamma-shielding components for use in storage and transportation canisters for high-level radioactive waste, particularly in the Multipurpose Canister (MPC) application. In addition to the waste-minimization benefits, spray casting would simplify the manufacturing process by allowing the shielding components for MPC to be produced as a single component, as opposed to multiple components with many fabrication and assembly steps. In earlier experiments, surrogate materials were used to simulate the properties (specifically reactivity and density) of DU. Based on the positive results from those studies, the project participants decided that further evaluation of the issues and concerns that would accompany spraying DU was warranted. That evaluation occupied substantially all of Fiscal Year 1995, yielding conceptual designs for both an intermediate facility and a production facility and their associated engineering estimates. An intermediate facility was included in this study to allow further technology development in spraying DU. Although spraying DU to near-net shape seems to be feasible, a number of technical, engineering, and safety issues would need to be evaluated before proceeding with a production facility. This report is intended to document the results from the spray-casting project and to provide information needed by anyone interested in proceeding to the next step

  19. Human genomics projects and precision medicine.

    Science.gov (United States)

    Carrasco-Ramiro, F; Peiró-Pastor, R; Aguado, B

    2017-09-01

    The completion of the Human Genome Project (HGP) in 2001 opened the floodgates to a deeper understanding of medicine. There are dozens of HGP-like projects which involve from a few tens to several million genomes currently in progress, which vary from having specialized goals or a more general approach. However, data generation, storage, management and analysis in public and private cloud computing platforms have raised concerns about privacy and security. The knowledge gained from further research has changed the field of genomics and is now slowly permeating into clinical medicine. The new precision (personalized) medicine, where genome sequencing and data analysis are essential components, allows tailored diagnosis and treatment according to the information from the patient's own genome and specific environmental factors. P4 (predictive, preventive, personalized and participatory) medicine is introducing new concepts, challenges and opportunities. This review summarizes current sequencing technologies, concentrates on ongoing human genomics projects, and provides some examples in which precision medicine has already demonstrated clinical impact in diagnosis and/or treatment.

  20. Genome projects and the functional-genomic era.

    Science.gov (United States)

    Sauer, Sascha; Konthur, Zoltán; Lehrach, Hans

    2005-12-01

    The problems we face today in public health as a result of the -- fortunately -- increasing age of people and the requirements of developing countries create an urgent need for new and innovative approaches in medicine and in agronomics. Genomic and functional genomic approaches have a great potential to at least partially solve these problems in the future. Important progress has been made by procedures to decode genomic information of humans, but also of other key organisms. The basic comprehension of genomic information (and its transfer) should now give us the possibility to pursue the next important step in life science eventually leading to a basic understanding of biological information flow; the elucidation of the function of all genes and correlative products encoded in the genome, as well as the discovery of their interactions in a molecular context and the response to environmental factors. As a result of the sequencing projects, we are now able to ask important questions about sequence variation and can start to comprehensively study the function of expressed genes on different levels such as RNA, protein or the cell in a systematic context including underlying networks. In this article we review and comment on current trends in large-scale systematic biological research. A particular emphasis is put on technology developments that can provide means to accomplish the tasks of future lines of functional genomics.

  1. Final ITER CTA project board meeting

    International Nuclear Information System (INIS)

    Vlasenkov, V.

    2003-01-01

    The final ITER CTA Project Board Meeting (PB) took place in Barcelona, Spain on 8 December 2002. The PB took notes of the comments concerning the status of the International Team and the Participants Teams, including Dr. Aymar's report 'From ITER to a FUSION Power Reactor' and the assessment of the ITER project cost estimate

  2. ROLL OUT THE TALENT : Final project report

    OpenAIRE

    Eerola, Tuomas; Tuominen, Pirjo; Hakkarainen, Riitta-Liisa; Laurikainen, Marja; Mero, Niina

    2014-01-01

    The ROLL OUT THE TALENT project was born out of the desire to recognise and support the strengths of vocational students and to develop new and innovative operating models. ROLL OUT THE TALENT promoted regional cooperation between institutes and companies. The project produced operating and study path models that take into consideration the individual strengths of vocational students and the principles of lifelong learning. This is the final report of the ROLL OUT THE TALENT project, and ...

  3. Justice and the Human Genome Project

    Energy Technology Data Exchange (ETDEWEB)

    Murphy, T.F.; Lappe, M. (eds.)

    1992-01-01

    Most of the essays gathered in this volume were first presented at a conference, Justice and the Human Genome, in Chicago in early November, 1991. The goal of the, conference was to consider questions of justice as they are and will be raised by the Human Genome Project. To achieve its goal of identifying and elucidating the challenges of justice inherent in genomic research and its social applications the conference drew together in one forum members from academia, medicine, and industry with interests divergent as rate-setting for insurance, the care of newborns, and the history of ethics. The essays in this volume address a number of theoretical and practical concerns relative to the meaning of genomic research.

  4. Justice and the Human Genome Project

    Energy Technology Data Exchange (ETDEWEB)

    Murphy, T.F.; Lappe, M. [eds.

    1992-12-31

    Most of the essays gathered in this volume were first presented at a conference, Justice and the Human Genome, in Chicago in early November, 1991. The goal of the, conference was to consider questions of justice as they are and will be raised by the Human Genome Project. To achieve its goal of identifying and elucidating the challenges of justice inherent in genomic research and its social applications the conference drew together in one forum members from academia, medicine, and industry with interests divergent as rate-setting for insurance, the care of newborns, and the history of ethics. The essays in this volume address a number of theoretical and practical concerns relative to the meaning of genomic research.

  5. Genomic Prediction from Whole Genome Sequence in Livestock: The 1000 Bull Genomes Project

    DEFF Research Database (Denmark)

    Hayes, Benjamin J; MacLeod, Iona M; Daetwyler, Hans D

    Advantages of using whole genome sequence data to predict genomic estimated breeding values (GEBV) include better persistence of accuracy of GEBV across generations and more accurate GEBV across breeds. The 1000 Bull Genomes Project provides a database of whole genome sequenced key ancestor bulls....... In a dairy data set, predictions using BayesRC and imputed sequence data from 1000 Bull Genomes were 2% more accurate than with 800k data. We could demonstrate the method identified causal mutations in some cases. Further improvements will come from more accurate imputation of sequence variant genotypes...

  6. The Human Genome Project and Biology Education.

    Science.gov (United States)

    McInerney, Joseph D.

    1996-01-01

    Highlights the importance of the Human Genome Project in educating the public about genetics. Discusses four challenges that science educators must address: teaching for conceptual understanding, the nature of science, the personal and social impact of science and technology, and the principles of technology. Contains 45 references. (JRH)

  7. Implications of the Human Genome Project

    Energy Technology Data Exchange (ETDEWEB)

    Kitcher, P.

    1998-11-01

    The Human Genome Project (HGP), launched in 1991, aims to map and sequence the human genome by 2006. During the fifteen-year life of the project, it is projected that $3 billion in federal funds will be allocated to it. The ultimate aims of spending this money are to analyze the structure of human DNA, to identify all human genes, to recognize the functions of those genes, and to prepare for the biology and medicine of the twenty-first century. The following summary examines some of the implications of the program, concentrating on its scientific import and on the ethical and social problems that it raises. Its aim is to expose principles that might be used in applying the information which the HGP will generate. There is no attempt here to translate the principles into detailed proposals for legislation. Arguments and discussion can be found in the full report, but, like this summary, that report does not contain any legislative proposals.

  8. The fracture zone project - final report

    International Nuclear Information System (INIS)

    Andersson, Peter

    1993-09-01

    This report summarizes the work and the experiences gained during the fracture zone project at the Finnsjoen study site. The project is probably the biggest effort, so far, to characterize a major fracture zone in crystalline bedrock. The project was running between 1984-1990 involving a large number of geological, geohydrological, geochemical, and geomechanical investigation. The methods used for identification and characterization are reviewed and discussed in terms of applicability and possible improvements for future investigations. The discussion is exemplified with results from the investigation within the project. Flow and transport properties of the zone determined from hydraulic tests and tracer tests are discussed. A large number of numerical modelling efforts performed within the fracture zone project, the INTRAVAL project, and the SKB91-study are summarized and reviewed. Finally, occurrence of similar zones and the relevance of major low angle fracture zones in connection to the siting of an underground repository is addressed

  9. Project Rio Blanco: site restoration. Final report

    International Nuclear Information System (INIS)

    1978-01-01

    Project Rio Blanco was a joint Government-industry experiment using nuclear explosives to stimulate the flow of natural gas from low permeability formations which could not be economically produced through conventional methods. The project consisted of the simultaneous detonation of three nuclear explosives on May 17, 1973, in a 7,000 foot well in northwestern Colorado. Gas production testing and project evaluation continued through June 1976. The site cleanup and restoration planning phase began in December 1975 and was concluded with the issuance of an operational plan, Project Rio Blanco Site Cleanup and Restoration Plan, NVO-173, in May 1976. Actual site restoration activities were conducted during the period from July to November 1976. The activities throughout the restoration period are summarized and the final site status, including the disposition of all project facilities and the status of all project related wells after plug and abandonment and recompletion work are described

  10. Origins of the Human Genome Project

    Energy Technology Data Exchange (ETDEWEB)

    Cook-Deegan, Robert

    1993-07-01

    The human genome project was borne of technology, grew into a science bureaucracy in the US and throughout the world, and is now being transformed into a hybrid academic and commercial enterprise. The next phase of the project promises to veer more sharply toward commercial application, harnessing both the technical prowess of molecular biology and the rapidly growing body of knowledge about DNA structure to the pursuit of practical benefits. Faith that the systematic analysis of DNA structure will prove to be a powerful research tool underlies the rationale behind the genome project. The notion that most genetic information is embedded in the sequence of CNA base pairs comprising chromosomes is a central tenet. A rough analogy is to liken an organism's genetic code to computer code. The coal of the genome project, in this parlance, is to identify and catalog 75,000 or more files (genes) in the software that directs construction of a self-modifying and self-replicating system -- a living organism.

  11. Origins of the Human Genome Project

    Science.gov (United States)

    Cook-Deegan, Robert (Affiliation: Institute of Medicine, National Academy of Sciences)

    1993-07-01

    The human genome project was borne of technology, grew into a science bureaucracy in the United States and throughout the world, and is now being transformed into a hybrid academic and commercial enterprise. The next phase of the project promises to veer more sharply toward commercial application, harnessing both the technical prowess of molecular biology and the rapidly growing body of knowledge about DNA structure to the pursuit of practical benefits. Faith that the systematic analysis of DNA structure will prove to be a powerful research tool underlies the rationale behind the genome project. The notion that most genetic information is embedded in the sequence of CNA base pairs comprising chromosomes is a central tenet. A rough analogy is to liken an organism's genetic code to computer code. The coal of the genome project, in this parlance, is to identify and catalog 75,000 or more files (genes) in the software that directs construction of a self-modifying and self-replicating system -- a living organism.

  12. A comprehensive crop genome research project: the Superhybrid Rice Genome Project in China.

    Science.gov (United States)

    Yu, Jun; Wong, Gane Ka-Shu; Liu, Siqi; Wang, Jian; Yang, Huanming

    2007-06-29

    In May 2000, the Beijing Institute of Genomics formally announced the launch of a comprehensive crop genome research project on rice genomics, the Chinese Superhybrid Rice Genome Project. SRGP is not simply a sequencing project targeted to a single rice (Oryza sativa L.) genome, but a full-swing research effort with an ultimate goal of providing inclusive basic genomic information and molecular tools not only to understand biology of the rice, both as an important crop species and a model organism of cereals, but also to focus on a popular superhybrid rice landrace, LYP9. We have completed the first phase of SRGP and provide the rice research community with a finished genome sequence of an indica variety, 93-11 (the paternal cultivar of LYP9), together with ample data on subspecific (between subspecies) polymorphisms, transcriptomes and proteomes, useful for within-species comparative studies. In the second phase, we have acquired the genome sequence of the maternal cultivar, PA64S, together with the detailed catalogues of genes uniquely expressed in the parental cultivars and the hybrid as well as allele-specific markers that distinguish parental alleles. Although SRGP in China is not an open-ended research programme, it has been designed to pave a way for future plant genomics research and application, such as to interrogate fundamentals of plant biology, including genome duplication, polyploidy and hybrid vigour, as well as to provide genetic tools for crop breeding and to carry along a social burden-leading a fight against the world's hunger. It began with genomics, the newly developed and industry-scale research field, and from the world's most populous country. In this review, we summarize our scientific goals and noteworthy discoveries that exploit new territories of systematic investigations on basic and applied biology of rice and other major cereal crops.

  13. Pac-Rim LNG project : final project report specifications

    International Nuclear Information System (INIS)

    1996-01-01

    PAC-RIM LNG Inc. has submitted a proposal to the British Columbia Environmental Assessment Office, to develop a liquefied natural gas project which would purchase pipeline quality natural gas from sources in northeast British Columbia and Alberta and transport it via a dedicated pipeline system to a LNG processing plant on tidewater on the Pacific coast. The project would include storage and processing facilities and a marine loading terminal. This document sets out the final project report specifications prepared by the Project Committee on the basis of input received from the public, First Nations and federal, provincial and local governments

  14. The African Genome Variation Project shapes medical genetics in Africa.

    Science.gov (United States)

    Gurdasani, Deepti; Carstensen, Tommy; Tekola-Ayele, Fasil; Pagani, Luca; Tachmazidou, Ioanna; Hatzikotoulas, Konstantinos; Karthikeyan, Savita; Iles, Louise; Pollard, Martin O; Choudhury, Ananyo; Ritchie, Graham R S; Xue, Yali; Asimit, Jennifer; Nsubuga, Rebecca N; Young, Elizabeth H; Pomilla, Cristina; Kivinen, Katja; Rockett, Kirk; Kamali, Anatoli; Doumatey, Ayo P; Asiki, Gershim; Seeley, Janet; Sisay-Joof, Fatoumatta; Jallow, Muminatou; Tollman, Stephen; Mekonnen, Ephrem; Ekong, Rosemary; Oljira, Tamiru; Bradman, Neil; Bojang, Kalifa; Ramsay, Michele; Adeyemo, Adebowale; Bekele, Endashaw; Motala, Ayesha; Norris, Shane A; Pirie, Fraser; Kaleebu, Pontiano; Kwiatkowski, Dominic; Tyler-Smith, Chris; Rotimi, Charles; Zeggini, Eleftheria; Sandhu, Manjinder S

    2015-01-15

    Given the importance of Africa to studies of human origins and disease susceptibility, detailed characterization of African genetic diversity is needed. The African Genome Variation Project provides a resource with which to design, implement and interpret genomic studies in sub-Saharan Africa and worldwide. The African Genome Variation Project represents dense genotypes from 1,481 individuals and whole-genome sequences from 320 individuals across sub-Saharan Africa. Using this resource, we find novel evidence of complex, regionally distinct hunter-gatherer and Eurasian admixture across sub-Saharan Africa. We identify new loci under selection, including loci related to malaria susceptibility and hypertension. We show that modern imputation panels (sets of reference genotypes from which unobserved or missing genotypes in study sets can be inferred) can identify association signals at highly differentiated loci across populations in sub-Saharan Africa. Using whole-genome sequencing, we demonstrate further improvements in imputation accuracy, strengthening the case for large-scale sequencing efforts of diverse African haplotypes. Finally, we present an efficient genotype array design capturing common genetic variation in Africa.

  15. The African Genome Variation Project shapes medical genetics in Africa

    Science.gov (United States)

    Gurdasani, Deepti; Carstensen, Tommy; Tekola-Ayele, Fasil; Pagani, Luca; Tachmazidou, Ioanna; Hatzikotoulas, Konstantinos; Karthikeyan, Savita; Iles, Louise; Pollard, Martin O.; Choudhury, Ananyo; Ritchie, Graham R. S.; Xue, Yali; Asimit, Jennifer; Nsubuga, Rebecca N.; Young, Elizabeth H.; Pomilla, Cristina; Kivinen, Katja; Rockett, Kirk; Kamali, Anatoli; Doumatey, Ayo P.; Asiki, Gershim; Seeley, Janet; Sisay-Joof, Fatoumatta; Jallow, Muminatou; Tollman, Stephen; Mekonnen, Ephrem; Ekong, Rosemary; Oljira, Tamiru; Bradman, Neil; Bojang, Kalifa; Ramsay, Michele; Adeyemo, Adebowale; Bekele, Endashaw; Motala, Ayesha; Norris, Shane A.; Pirie, Fraser; Kaleebu, Pontiano; Kwiatkowski, Dominic; Tyler-Smith, Chris; Rotimi, Charles; Zeggini, Eleftheria; Sandhu, Manjinder S.

    2015-01-01

    Given the importance of Africa to studies of human origins and disease susceptibility, detailed characterization of African genetic diversity is needed. The African Genome Variation Project provides a resource with which to design, implement and interpret genomic studies in sub-Saharan Africa and worldwide. The African Genome Variation Project represents dense genotypes from 1,481 individuals and whole-genome sequences from 320 individuals across sub-Saharan Africa. Using this resource, we find novel evidence of complex, regionally distinct hunter-gatherer and Eurasian admixture across sub-Saharan Africa. We identify new loci under selection, including loci related to malaria susceptibility and hypertension. We show that modern imputation panels (sets of reference genotypes from which unobserved or missing genotypes in study sets can be inferred) can identify association signals at highly differentiated loci across populations in sub-Saharan Africa. Using whole-genome sequencing, we demonstrate further improvements in imputation accuracy, strengthening the case for large-scale sequencing efforts of diverse African haplotypes. Finally, we present an efficient genotype array design capturing common genetic variation in Africa.

  16. The African Genome Variation Project shapes medical genetics in Africa

    Science.gov (United States)

    Gurdasani, Deepti; Carstensen, Tommy; Tekola-Ayele, Fasil; Pagani, Luca; Tachmazidou, Ioanna; Hatzikotoulas, Konstantinos; Karthikeyan, Savita; Iles, Louise; Pollard, Martin O.; Choudhury, Ananyo; Ritchie, Graham R. S.; Xue, Yali; Asimit, Jennifer; Nsubuga, Rebecca N.; Young, Elizabeth H.; Pomilla, Cristina; Kivinen, Katja; Rockett, Kirk; Kamali, Anatoli; Doumatey, Ayo P.; Asiki, Gershim; Seeley, Janet; Sisay-Joof, Fatoumatta; Jallow, Muminatou; Tollman, Stephen; Mekonnen, Ephrem; Ekong, Rosemary; Oljira, Tamiru; Bradman, Neil; Bojang, Kalifa; Ramsay, Michele; Adeyemo, Adebowale; Bekele, Endashaw; Motala, Ayesha; Norris, Shane A.; Pirie, Fraser; Kaleebu, Pontiano; Kwiatkowski, Dominic; Tyler-Smith, Chris; Rotimi, Charles; Zeggini, Eleftheria; Sandhu, Manjinder S.

    2014-01-01

    Given the importance of Africa to studies of human origins and disease susceptibility, detailed characterisation of African genetic diversity is needed. The African Genome Variation Project (AGVP) provides a resource to help design, implement and interpret genomic studies in sub-Saharan Africa (SSA) and worldwide. The AGVP represents dense genotypes from 1,481 and whole genome sequences (WGS) from 320 individuals across SSA. Using this resource, we find novel evidence of complex, regionally distinct hunter-gatherer and Eurasian admixture across SSA. We identify new loci under selection, including for malaria and hypertension. We show that modern imputation panels can identify association signals at highly differentiated loci across populations in SSA. Using WGS, we show further improvement in imputation accuracy supporting efforts for large-scale sequencing of diverse African haplotypes. Finally, we present an efficient genotype array design capturing common genetic variation in Africa, showing for the first time that such designs are feasible. PMID:25470054

  17. Final Report of the Final Meeting of Project Coordinators

    International Nuclear Information System (INIS)

    Cordero Calderon, Carlos F.

    1996-06-01

    The Costa Rican Electricity Institute has always been worried of the verification of the good state of the works and thus to guarantee their operation. For that reason, it has established different sorts of auscultation of the Arenal's Dam. Some investigations have been done to find new methods to improve and to eliminate risks in different works or projects. The Arenal's Dam is one of the greatest engineering works in Costa Rica, it has the Arenal, Corobici and Sandillal Hydroelectric Plants. Furthermore, the irrigation system in the Tempisque River Valley, in the Guanacaste province. One special characteristic of the Site of the Dam, is the near location of the Arenal Volcano, in full activity and located at 6 Km. from the dam. This report has two goals, one is the traditional permanent measurements report for the project, and the other, is to present it as a final work of the Project Arcal XVIII, to the International Atomic Energy Agency. This report analyses the geo-hydraulic, structural and topographic auscultation, as well as the activities accomplished during the ARCAL XVIII /8/018, Application of Tracer Techniques for Leakage in Dams and Damming Project, based on information gathered through the geo-chemical auscultation, until June 1996. (author).30 ills., 80 charts, 35 tabs

  18. An overview of the human genome project

    Energy Technology Data Exchange (ETDEWEB)

    Batzer, M.A.

    1994-01-01

    The human genome project is one of the most ambitious scientific projects to date, with the ultimate goal being a nucleotide sequence for all four billion bases of human DNA. In the process of determining the nucleotide sequence for each base, the location, function, and regulatory regions from the estimated 100,000 human genes will be identified. The genome project itself relies upon maps of the human genetic code derived from several different levels of resolution. Genetic linkage analysis provides a low resolution genome map. The information for genetic linkage maps is derived from the analysis of chromosome specific markers such as Sequence Tagged Sites (STSs), Variable Number of Tandem Repeats (VNTRs) or other polymorphic (highly informative) loci in a number of different-families. Using this information the location of an unknown disease gene can be limited to a region comprised of one million base pairs of DNA or less. After this point, one must construct or have access to a physical map of the region of interest. Physical mapping involves the construction of an ordered overlapping (contiguous) set of recombinant DNA clones. These clones may be derived from a number of different vectors including cosmids, Bacterial Artificial Chromosomes (BACs), P1 derived Artificial Chromosomes (PACs), somatic cell hybrids, or Yeast Artificial Chromosomes (YACs). The ultimate goal for physical mapping is to establish a completely overlapping (contiguous) set of clones for the entire genome. After a gene or region of interest has been localized using physical mapping the nucleotide sequence is determined. The overlap between genetic mapping, physical mapping and DNA sequencing has proven to be a powerful tool for the isolation of disease genes through positional cloning.

  19. Leven estuary project. Fisheries Department final report

    OpenAIRE

    Bayliss, B.D.

    1997-01-01

    This is the report on the Leven estuary project: Fisheries Department final report produced by the Environment Agency North West in 1997. This report contains information about Leven estuary, river Leven catchment, river Crake catchment and the Ulverston Discharges. The Leven estuary is characterised by being very shallow, and shares the extremely variable tides and currents that characterize the whole of Morecambe Bay. There was little detailed knowledge of the impact on the Leven estuary, a...

  20. Northeast Oregon Hatchery Project final siting report. Final report

    International Nuclear Information System (INIS)

    1995-03-01

    This report presents the results of site analysis for the Bonneville Power Administration Northeast Oregon Hatchery Project. The purpose of this project is to provide engineering services for the siting and conceptual design of hatchery facilities for the Bonneville Power Administration. The hatchery project consists of artificial production facilities for salmon and steelhead to enhance production in three adjacent tributaries to the Columbia River in northeast Oregon: the Grande Ronde, Walla Walla, and Imnaha River drainage basins. Facilities identified in the master plan include adult capture and holding facilities; spawning incubation, and early rearing facilities; full-term rearing facilities; and direct release or acclimation facilities. The evaluation includes consideration of a main production facility for one or more of the basins or several smaller satellite production facilities to be located within major subbasins. The historic and current distribution of spring and fall chinook salmon and steelhead was summarized for the Columbia River tributaries. Current and future production and release objectives were reviewed. Among the three tributaries, forty seven sites were evaluated and compared to facility requirements for water and space. Site screening was conducted to identify the sites with the most potential for facility development. Alternative sites were selected for conceptual design of each facility type. A proposed program for adult holding facilities, final rearing/acclimation, and direct release facilities was developed

  1. Prototypical Consolidation Demonstration Project: Final report

    International Nuclear Information System (INIS)

    Gili, J.A.; Poston, V.K.

    1993-11-01

    This is the final report of the Prototypical Consolidation Demonstration Project, which was funded by the US Department of Energy's Office of Civilian Radioactive Waste Management. The project had two objectives: (a) to develop and demonstrate a prototype of production-scale equipment for the dry, horizontal consolidation and packaging of spent nuclear fuel rods from commercial boiling water reactor and pressurized water reactor fuel assemblies, and (b) to report the development and demonstration results to the US Department of Energy, Idaho Operations Office. This report summarizes the activities and conclusions of the project management contractor, EG ampersand G Idaho, Inc., and the fabrication and testing contractor, NUS Corporation (NUS). The report also presents EG ampersand G Idaho's assessments of the equipment and procedures developed by NUS

  2. The Human Genome Project (HGP): dividends and challenges: a ...

    African Journals Online (AJOL)

    The Human Genome Project (HGP): dividends and challenges: a review. ... Genomic studies have given profound insights into the genetic organization of ... with it will be an essential part of modern medicine and biology for years to come.

  3. Freedom and Responsibility in Synthetic Genomics: The Synthetic Yeast Project

    OpenAIRE

    Sliva, Anna; Yang, Huanming; Boeke, Jef D.; Mathews, Debra J. H.

    2015-01-01

    First introduced in 2011, the Synthetic Yeast Genome (Sc2.0) Project is a large international synthetic genomics project that will culminate in the first eukaryotic cell (Saccharomyces cerevisiae) with a fully synthetic genome. With collaborators from across the globe and from a range of institutions spanning from do-it-yourself biology (DIYbio) to commercial enterprises, it is important that all scientists working on this project are cognizant of the ethical and policy issues associated with...

  4. Northeast Oregon Hatchery Project, Final Siting Report.

    Energy Technology Data Exchange (ETDEWEB)

    Watson, Montgomery

    1995-03-01

    This report presents the results of site analysis for the Bonneville Power Administration Northeast Oregon Hatchery Project. The purpose of this project is to provide engineering services for the siting and conceptual design of hatchery facilities for the Bonneville Power Administration. The hatchery project consists of artificial production facilities for salmon and steelhead to enhance production in three adjacent tributaries to the Columbia River in northeast Oregon: the Grande Ronde, Walla Walla, and Imnaha River drainage basins. Facilities identified in the master plan include adult capture and holding facilities; spawning incubation, and early rearing facilities; full-term rearing facilities; and direct release or acclimation facilities. The evaluation includes consideration of a main production facility for one or more of the basins or several smaller satellite production facilities to be located within major subbasins. The historic and current distribution of spring and fall chinook salmon and steelhead was summarized for the Columbia River tributaries. Current and future production and release objectives were reviewed. Among the three tributaries, forty seven sites were evaluated and compared to facility requirements for water and space. Site screening was conducted to identify the sites with the most potential for facility development. Alternative sites were selected for conceptual design of each facility type. A proposed program for adult holding facilities, final rearing/acclimation, and direct release facilities was developed.

  5. The modest beginnings of one genome project.

    Science.gov (United States)

    Kaback, David B

    2013-06-01

    One of the top things on a geneticist's wish list has to be a set of mutants for every gene in their particular organism. Such a set was produced for the yeast, Saccharomyces cerevisiae near the end of the 20th century by a consortium of yeast geneticists. However, the functional genomic analysis of one chromosome, its smallest, had already begun more than 25 years earlier as a project that was designed to define most or all of that chromosome's essential genes by temperature-sensitive lethal mutations. When far fewer than expected genes were uncovered, the relatively new field of molecular cloning enabled us and indeed, the entire community of yeast researchers to approach this problem more definitively. These studies ultimately led to cloning, genomic sequencing, and the production and phenotypic analysis of the entire set of knockout mutations for this model organism as well as a better concept of what defines an essential function, a wish fulfilled that enables this model eukaryote to continue at the forefront of research in modern biology.

  6. Griffith energy project final environmental impact statement

    International Nuclear Information System (INIS)

    1999-03-01

    Griffith Energy Limited Liability Corporation (Griffith) proposes to construct and operate the Griffith Energy Project (Project), a natural gas-fired, combined cycle power plant, on private lands south of Kingman, Arizona. The Project would be a merchant plant which means that it is not owned by a utility and there is currently no long-term commitment or obligation by any utility to purchase the capacity and energy generated by the power plant. Griffith applied to interconnect its proposed power plant with the Western Area Power Administration's (Western) Pacific Northwest-Pacific Southwest Intertie and Parker-Davis transmission systems. Western, as a major transmission system owner, needs to provide access to its transmission system when it is requested by an eligible organization per existing policies, regulations and laws. The proposed interconnection would integrate the power generated by the Project into the regional transmission grid and would allow Griffith to supply its power to the competitive electric wholesale market. Based on the application, Western's proposed action is to enter into an interconnection and construction agreement with Griffith for the requested interconnections. The proposed action includes the power plant, water wells and transmission line, natural gas pipelines, new electrical transmission lines and a substation, upgrade of an existing transmission line, and access road to the power plant. Construction of segments of the transmission lines and a proposed natural gas pipeline also require a grant of right-of-way across Federal lands administered by the Bureau of Land Management. Public comments on the Draft EIS are addressed in the Final EIS, including addenda and modifications made as a result of the comments and/or new information

  7. Griffith Energy Project Final Environmental Impact Statement

    Energy Technology Data Exchange (ETDEWEB)

    N/A

    1999-04-02

    Griffith Energy Limited Liability Corporation (Griffith) proposes to construct and operate the Griffith Energy Project (Project), a natural gas-fuel, combined cycle power plant, on private lands south of Kingman, Ariz. The Project would be a ''merchant plant'' which means that it is not owned by a utility and there is currently no long-term commitment or obligation by any utility to purchase the capacity and energy generated by the power plant. Griffith applied to interconnect its proposed power plant with the Western Area Power Administration's (Western) Pacific Northwest-Pacific Southwest Intertie and Parker-Davis transmission systems. Western, as a major transmission system owner, needs to provide access to its transmission system when it is requested by an eligible organization per existing policies, regulations and laws. The proposed interconnection would integrate the power generated by the Project into the regional transmission grid and would allow Griffith to supply its power to the competitive electric wholesale market. Based on the application, Western's proposed action is to enter into an interconnection and construction agreement with Griffith for the requested interconnections. The proposed action includes the power plant, water wells and transmission line, natural gas pipelines, new electrical transmission lines and a substation, upgrade of an existing transmission line, and access road to the power plant. Construction of segments of the transmission lines and a proposed natural gas pipeline also require a grant of right-of-way across Federal lands administered by the Bureau of Land Management. Public comments on the Draft EIS are addressed in the Final EIS, including addenda and modifications made as a result of the comments and/or new information.

  8. SPEAR 3 Upgrade Project: The Final Year

    International Nuclear Information System (INIS)

    Hettel, R

    2004-01-01

    During April, 2003, the SPEAR 2 storage ring, which served the high energy physics community from 1972 to 1987, and the synchrotron radiation community for an additional 15 years, was removed from its shielding tunnel in order to install the new 3-GeV, 500-mA SPEAR 3 light source. From May to November, SSRL will excavate the tunnel floor and pour a new concrete floor, and then install pre-assembled girders holding magnets, copper vacuum chambers, PEP-II-style rf cavities, and beam line front end components. At the same time, power supply, instrumentation and control, and other ancillary systems will be configured, leading to a commissioning period beginning in November 2003. The progress of accelerator component implementation and installation during the final year of the project will be reviewed

  9. N Area Final Project Program Plan

    International Nuclear Information System (INIS)

    Day, R.S.; Duncan, G.M; Trent, S.J.

    1998-07-01

    The N Area Final Project Program Plan is issued for information and use by the U.S. Department of Energy (DOE), the Environmental Restoration Contractor (ERC) for the Hanford Site, and other parties that require workscope knowledge for the deactivation of N Reactor facilities and remediation of the 100-N Area. This revision to the program plan contains the updated critical path schedule to deactivate N Reactor and its supporting facilities, cleanout of the N Reactor Fuel Storage Basin (105-N Basin), and remediate the 100-N Area. This document reflects notable changes in the deactivation plan for N Reactor, including changes in deactivation status, the N Basin cleanout task, and 100-N Area remediation

  10. Project No. 8 - Final decommissioning plan

    International Nuclear Information System (INIS)

    2000-01-01

    Ignalina NPP should prepare the final Ignalina NPP unit 1 decommissioning plan by march 31, 2002. This plan should include the following : description of Ignalina NPP and the Ignalina NPP boundary that could be influenced by decommissioning process; decommissioning strategy selected and a logical substantiation for this selection; description of the decommissioning actions suggested and a time schedule for the actions to be performed; conceptual safety and environmental impact assessment covering ionizing radiation and other man and environment impact; description of the environmental monitoring program proposed during decommissioning process; description of the waste management proposed; assessment of decommissioning expenses including waste management, accumulated funds and other sources. Estimated project cost - 0.75 M EURO

  11. A 1000 Arab genome project to study the Emirati population.

    Science.gov (United States)

    Al-Ali, Mariam; Osman, Wael; Tay, Guan K; AlSafar, Habiba S

    2018-04-01

    Discoveries from the human genome, HapMap, and 1000 genome projects have collectively contributed toward the creation of a catalog of human genetic variations that has improved our understanding of human diversity. Despite the collegial nature of many of these genome study consortiums, which has led to the cataloging of genetic variations of different ethnic groups from around the world, genome data on the Arab population remains overwhelmingly underrepresented. The National Arab Genome project in the United Arab Emirates (UAE) aims to address this deficiency by using Next Generation Sequencing (NGS) technology to provide data to improve our understanding of the Arab genome and catalog variants that are unique to the Arab population of the UAE. The project was conceived to shed light on the similarities and differences between the Arab genome and those of the other ethnic groups.

  12. The LiveWire Project final report

    Energy Technology Data Exchange (ETDEWEB)

    Brown, C.D.; Nelson, T.T. [Enova Technology, San Diego, CA (United States); Kelly, J.C.; Dominguez, H.A. [Paragon Consulting Services, La Verne, CA (United States)

    1997-10-01

    Utilities across the US have begun pilot testing a variety of hardware and software products to develop a two-way communications system between themselves and their customers. Their purpose is to reduce utility operating costs and to provide new and improved services for customers in light of pending changes in the electric industry being brought about by deregulation. A consortium including utilities, national labs, consultants, and contractors, with the support of the Department of Energy (DOE) and the Electric Power Research Institute (EPRI), initiated a project that utilized a hybrid fiber-coax (HFC) wide-area network integrated with a CEBus based local area network within the customers home. The system combined energy consumption data taken within the home, and home automation features to provide a suite of energy management services for residential customers. The information was transferred via the Internet through the HFC network, and presented to the customer on their personal computer. This final project report discusses the design, prototype testing, and system deployment planning of the energy management system.

  13. Skate Genome Project: Cyber-Enabled Bioinformatics Collaboration

    Science.gov (United States)

    Vincent, J.

    2011-01-01

    The Skate Genome Project, a pilot project of the North East Cyber infrastructure Consortium, aims to produce a draft genome sequence of Leucoraja erinacea, the Little Skate. The pilot project was designed to also develop expertise in large scale collaborations across the NECC region. An overview of the bioinformatics and infrastructure challenges faced during the first year of the project will be presented. Results to date and lessons learned from the perspective of a bioinformatics core will be highlighted.

  14. The Human Genome Project: how do we protect Australians?

    Science.gov (United States)

    Stott Despoja, N

    It is the moon landing of the nineties: the ambitious Human Genome Project--identifying the up to 100,000 genes that make up human DNA and the sequences of the three billion base-pairs that comprise the human genome. However, unlike the moon landing, the effects of the genome project will have a fundamental impact on the way we see ourselves and each other.

  15. Enewetak radiological support project. Final report

    International Nuclear Information System (INIS)

    Friesen, B.

    1982-09-01

    From 1972 through 1980, the Department of Energy acted in an advisory role to the Defense Nuclear Agency during planning for and execution of the cleanup of Enewetak Atoll. The Nevada Operations Office of the Department of Energy was responsible for the radiological characterization of the atoll and for certification of radiological condition of each island upon completion of the project. In-situ measurements of gamma rays emitted by americium-241 were utilized along with wet chemistry separation of plutonium from soil samples to identify and delineate surface areas requiring removal of soil. Military forces removed over 100,000 cubic yards of soil from the surface of five islands and deposited this material in a crater remaining from the nuclear testing period. Subsurface soil was excavated and removed from several locations where measurements indicated the presence of radionuclides above predetermined criteria. The methodologies of data acquisition, analysis and interpretation are described and detailed results are provided in text, figures and microfiche. The final radiological condition of each of 43 islets is reported

  16. Virginia Solar Pathways Project Final Technical Report

    Energy Technology Data Exchange (ETDEWEB)

    Bond, Katharine; Cosby, Sarah

    2018-03-28

    This Report provides a technical review of the final results of a funding award to Virginia Electric and Power Company (Dominion Energy Virginia (DEV) or the Company) for a project under the U.S. Department of Energy’s Solar Energy Technologies Office. The three-year project was formally known as the Virginia Solar Pathways Project (VSPP or the Project). The purpose of the VSPP was to develop a collaborative utility-administered solar strategy (Solar Strategy) for DEV’s service territory in the Commonwealth that could serve as a replicable model for other states with similar policy environments. The U.S. Department of Energy (DOE) funding award enabled DEV to take a focused approach to developing the Solar Strategy for its Virginia service territory. The structure and funding from the DOE award also facilitated valuable input from a formal stakeholder team convened to serve as advisors (Advisory Team) to the VSPP and contribute their perspectives and expertise to both the analysis and strategy development aspects of the Project. The development of the Solar Strategy involved three main goals: • Establish a policy and program framework that would integrate existing solar programs with new options appropriate for the Commonwealth’s policy environment and broader economic development objectives; • Promote wider deployment of solar within a low retail electric rate environment; and • Serve as a sustainable, utility-administered solar model that could be replicated in other states with similar policy environments, including, but not limited to, the entire Southeast region. In support of the VSPP goals, the Project Team commissioned four studies to support the Solar Strategy development. Two studies, completed by Navigant Consulting, focused on the integration of solar into the electric grid. The first solar integration study focused on integration of solar into the distribution grid where the utility system directly connects to and serves end-use customers

  17. WP1 – Final project report

    NARCIS (Netherlands)

    Drachsler, Hendrik; Scheffel, Maren; Orrego, Carola; Stieger, Lina; Hartkopf, Kathleen; Henn, Patrick; Hynes, Helen; Przibilla, Monika; Geiger, Uschi; Schroeder, Hanna; Sopka, Sasa

    2015-01-01

    This report contains the complete project reporting of the PATIENT project from October 2012 until end of March 2015. It provides a summary of all project activities and achievements that are based on the previous WP deliverables such as the project progress reports from WP1 (D1.01) and the quality

  18. GI-POP: a combinational annotation and genomic island prediction pipeline for ongoing microbial genome projects.

    Science.gov (United States)

    Lee, Chi-Ching; Chen, Yi-Ping Phoebe; Yao, Tzu-Jung; Ma, Cheng-Yu; Lo, Wei-Cheng; Lyu, Ping-Chiang; Tang, Chuan Yi

    2013-04-10

    Sequencing of microbial genomes is important because of microbial-carrying antibiotic and pathogenetic activities. However, even with the help of new assembling software, finishing a whole genome is a time-consuming task. In most bacteria, pathogenetic or antibiotic genes are carried in genomic islands. Therefore, a quick genomic island (GI) prediction method is useful for ongoing sequencing genomes. In this work, we built a Web server called GI-POP (http://gipop.life.nthu.edu.tw) which integrates a sequence assembling tool, a functional annotation pipeline, and a high-performance GI predicting module, in a support vector machine (SVM)-based method called genomic island genomic profile scanning (GI-GPS). The draft genomes of the ongoing genome projects in contigs or scaffolds can be submitted to our Web server, and it provides the functional annotation and highly probable GI-predicting results. GI-POP is a comprehensive annotation Web server designed for ongoing genome project analysis. Researchers can perform annotation and obtain pre-analytic information include possible GIs, coding/non-coding sequences and functional analysis from their draft genomes. This pre-analytic system can provide useful information for finishing a genome sequencing project. Copyright © 2012 Elsevier B.V. All rights reserved.

  19. Kansas Advanced Semiconductor Project: Final Report

    International Nuclear Information System (INIS)

    Baringer, P.; Bean, A.; Bolton, T.; Horton-Smith, G.; Maravin, Y.; Ratra, B.; Stanton, N.; von Toerne, E.; Wilson, G.

    2007-01-01

    KASP (Kansas Advanced Semiconductor Project) completed the new Layer 0 upgrade for D0, assumed key electronics projects for the US CMS project, finished important new physics measurements with the D0 experiment at Fermilab, made substantial contributions to detector studies for the proposed e+e- international linear collider (ILC), and advanced key initiatives in non-accelerator-based neutrino physics.

  20. Reactor vessel decommissioning project. Final report

    International Nuclear Information System (INIS)

    Schoonen, D.H.

    1984-09-01

    This report describes a reactor vessel decommissioning project; it documents and explains the project objectives, scope, performance results, and sodium removal process. The project was successfully completed in FY-1983, within budget and without significant problems or adverse impact on the environment. Waste generated by the operation included the reactor vessel, drained sodium, and liquid, solid, and gaseous wastes which were significantly less than project estimates. Personnel radiation exposures were minimized, such that the project total was one-half the predicted exposure level. Except for the sodium removed, the material remaining in the reactor vessel is essentially the same as when the vessel arrived for processing

  1. Energy Storage and Distributed Energy Generation Project, Final Project Report

    Energy Technology Data Exchange (ETDEWEB)

    Schwank, Johannes; Mader, Jerry; Chen, Xiaoyin; Mi, Chris; Linic, Suljo; Sastry, Ann Marie; Stefanopoulou, Anna; Thompson, Levi; Varde, Keshav

    2008-03-31

    This report serves as a Final Report under the “Energy Storage and Distribution Energy Generation Project” carried out by the Transportation Energy Center (TEC) at the University of Michigan (UM). An interdisciplinary research team has been working on fundamental and applied research on: -distributed power generation and microgrids, -power electronics, and -advanced energy storage. The long-term objective of the project was to provide a framework for identifying fundamental research solutions to technology challenges of transmission and distribution, with special emphasis on distributed power generation, energy storage, control methodologies, and power electronics for microgrids, and to develop enabling technologies for novel energy storage and harvesting concepts that can be simulated, tested, and scaled up to provide relief for both underserved and overstressed portions of the Nation’s grid. TEC’s research is closely associated with Sections 5.0 and 6.0 of the DOE "Five-year Program Plan for FY2008 to FY2012 for Electric Transmission and Distribution Programs, August 2006.”

  2. Comparative genomic data of the Avian Phylogenomics Project.

    Science.gov (United States)

    Zhang, Guojie; Li, Bo; Li, Cai; Gilbert, M Thomas P; Jarvis, Erich D; Wang, Jun

    2014-01-01

    genomic data that has been generated and used in our Avian Phylogenomics Project. To the best of our knowledge, the Avian Phylogenomics Project is the biggest vertebrate comparative genomics project to date. The genomic data presented here is expected to accelerate further analyses in many fields, including phylogenetics, comparative genomics, evolution, neurobiology, development biology, and other related areas.

  3. A computational genomics pipeline for prokaryotic sequencing projects.

    Science.gov (United States)

    Kislyuk, Andrey O; Katz, Lee S; Agrawal, Sonia; Hagen, Matthew S; Conley, Andrew B; Jayaraman, Pushkala; Nelakuditi, Viswateja; Humphrey, Jay C; Sammons, Scott A; Govil, Dhwani; Mair, Raydel D; Tatti, Kathleen M; Tondella, Maria L; Harcourt, Brian H; Mayer, Leonard W; Jordan, I King

    2010-08-01

    New sequencing technologies have accelerated research on prokaryotic genomes and have made genome sequencing operations outside major genome sequencing centers routine. However, no off-the-shelf solution exists for the combined assembly, gene prediction, genome annotation and data presentation necessary to interpret sequencing data. The resulting requirement to invest significant resources into custom informatics support for genome sequencing projects remains a major impediment to the accessibility of high-throughput sequence data. We present a self-contained, automated high-throughput open source genome sequencing and computational genomics pipeline suitable for prokaryotic sequencing projects. The pipeline has been used at the Georgia Institute of Technology and the Centers for Disease Control and Prevention for the analysis of Neisseria meningitidis and Bordetella bronchiseptica genomes. The pipeline is capable of enhanced or manually assisted reference-based assembly using multiple assemblers and modes; gene predictor combining; and functional annotation of genes and gene products. Because every component of the pipeline is executed on a local machine with no need to access resources over the Internet, the pipeline is suitable for projects of a sensitive nature. Annotation of virulence-related features makes the pipeline particularly useful for projects working with pathogenic prokaryotes. The pipeline is licensed under the open-source GNU General Public License and available at the Georgia Tech Neisseria Base (http://nbase.biology.gatech.edu/). The pipeline is implemented with a combination of Perl, Bourne Shell and MySQL and is compatible with Linux and other Unix systems.

  4. The Human Genome Project: big science transforms biology and medicine.

    Science.gov (United States)

    Hood, Leroy; Rowen, Lee

    2013-01-01

    The Human Genome Project has transformed biology through its integrated big science approach to deciphering a reference human genome sequence along with the complete sequences of key model organisms. The project exemplifies the power, necessity and success of large, integrated, cross-disciplinary efforts - so-called 'big science' - directed towards complex major objectives. In this article, we discuss the ways in which this ambitious endeavor led to the development of novel technologies and analytical tools, and how it brought the expertise of engineers, computer scientists and mathematicians together with biologists. It established an open approach to data sharing and open-source software, thereby making the data resulting from the project accessible to all. The genome sequences of microbes, plants and animals have revolutionized many fields of science, including microbiology, virology, infectious disease and plant biology. Moreover, deeper knowledge of human sequence variation has begun to alter the practice of medicine. The Human Genome Project has inspired subsequent large-scale data acquisition initiatives such as the International HapMap Project, 1000 Genomes, and The Cancer Genome Atlas, as well as the recently announced Human Brain Project and the emerging Human Proteome Project.

  5. The Human Genome Project: An Imperative for International Collaboration.

    Science.gov (United States)

    Allende, J. E.

    1989-01-01

    Discussed is the Human Genome Project which aims to decipher the totality of the human genetic information. The historical background, the objectives, international cooperation, ethical discussion, and the role of UNESCO are included. (KR)

  6. Project Final Report: HPC-Colony II

    Energy Technology Data Exchange (ETDEWEB)

    Jones, Terry R [ORNL; Kale, Laxmikant V [University of Illinois, Urbana-Champaign; Moreira, Jose [IBM T. J. Watson Research Center

    2013-11-01

    This report recounts the HPC Colony II Project which was a computer science effort funded by DOE's Advanced Scientific Computing Research office. The project included researchers from ORNL, IBM, and the University of Illinois at Urbana-Champaign. The topic of the effort was adaptive system software for extreme scale parallel machines. A description of findings is included.

  7. The Oregon Applied Academics Project: Final Report

    Science.gov (United States)

    Pearson, Donna; Richardson, George B.; Sawyer, Jennifer M.

    2013-01-01

    This report contains the findings of the Oregon Applied Academics research and development project which spanned three academic years from 2010 through 2013. The overall purpose of the project was to develop and implement a technical math course that would meet graduation requirements and improve student performance. The State of Oregon has been…

  8. The ICE-CREAM Project : final report

    NARCIS (Netherlands)

    Janse, M.D.

    2004-01-01

    The ICE-CREAM project has been investigating how to make compelling experiences for end-users based on enabling technologies for interactive media, such as DVB-MHP, Internet and MPEG-4. The goals of the project were to extend the notion of interaction, to exploit domestic activities and familiar

  9. Project Elderly. Interim and Final Reports.

    Science.gov (United States)

    Miami-Dade Community Coll., FL.

    This report examines Project Elderly, a project developed to provide job possibilities for the older adult in the labor market in metropolitan Miami (FL). A survey questionnaire was developed to (1) assess the opportunities of the elderly for re-entry into volunteer and paid employment positions; (2) determine the extent of the senior population…

  10. Project CAREER/CAN. Final Evaluation Report.

    Science.gov (United States)

    National Educational Evaluation Services, Inc., Chestnut Hill, MA.

    A description and evaluation of (1) the development of the 4-column process which completes the behavioral objective data base, (2) the development of the computer retrieval capability, and (3) the pilot testing of the product in high school classrooms are included in this summative evaluation of Project CAREER/CAN. (Goals of Project CAREER/CAN,…

  11. Hispanic Vocational Exploration Project. Final Report.

    Science.gov (United States)

    Centro De La Comunidad, Inc., New London, CT.

    During its second year, the Hispanic Vocational Exploration Project recruited eighth and ninth grade Hispanic youth for a four-week cycle, after-school, career exploratory program at Southeastern Regional Vocational Technical School, Groton, Connecticut. A series of career education workshops was the other major project activity. Supportive…

  12. LYNX community advocacy & service engagement (CASE) project final report.

    Science.gov (United States)

    2009-05-14

    This report is a final assessment of the Community Advocacy & Service Engagement (CASE) project, a LYNX-FTA research project designed : to study transit education and public engagement methods in Central Florida. In the Orlando area, as in other part...

  13. The Human Genome Project: big science transforms biology and medicine

    OpenAIRE

    Hood, Leroy; Rowen, Lee

    2013-01-01

    The Human Genome Project has transformed biology through its integrated big science approach to deciphering a reference human genome sequence along with the complete sequences of key model organisms. The project exemplifies the power, necessity and success of large, integrated, cross-disciplinary efforts - so-called ‘big science’ - directed towards complex major objectives. In this article, we discuss the ways in which this ambitious endeavor led to the development of novel technologies and a...

  14. Resource Roads demonstration project : final report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2009-07-15

    British Columbia's vast network of resource roads are considered to be amongst the most dangerous, high-risk workplaces in the province. Resource roads, also known as industrial roads, forest service roads, or petroleum development roads, present several unique safety challenges as workplaces. They are built for the purpose of access, egress and transport of materials, resources, equipment and people. However, the lack the same diligence of enforcement and a consistent design, construction, maintenance and standard for use as public highways or municipal roads. There are also safety challenges related to public use of resource roads. This report presented a project, called ResourceRoads by WorkSafe BC that focused on the organization and implementation of a management structure that would provide a system of coordination and a process of compliance for the users of the defined road systems. The project was based on information gathered in two forest districts of Prince George and the South Peace Forest Districts. A committee consisting of the actual owner of the road and other users was formed. The report presented a history of British Columbia's resource road system, and discussed resource roads as industrial workplaces and worksites, as well as resource road fatality statistics. The demonstration project was outlined in terms of project leadership; scope; strategic objectives; project purpose; performance objectives; project communication; demonstration areas; and project stages. Project fundamentals and project findings were also presented along with recommendations and responses to the Auditor General report and the Forest Safety Ombudsman report. It was concluded that potential uses of new technologies for resource road vehicles should be reviewed. tabs., figs.

  15. The final focus test beam project

    International Nuclear Information System (INIS)

    Burke, D.

    1991-05-01

    An overview is given of the Final Focus Test Beam (FFTB) that is being constructed as a prototype final focus system for a future electron-positron linear collider. This beam line will use as input the 50 GeV electron beam from the SLC linac, and is designed to reduce the transverse dimensions of the beam spot at the focal point to 1 μm. 5 refs., 2 figs., 1 tab

  16. National human genome projects: an update and an agenda.

    Science.gov (United States)

    An, Joon Yong

    2017-01-01

    Population genetic and human genetic studies are being accelerated with genome technology and data sharing. Accordingly, in the past 10 years, several countries have initiated genetic research using genome technology and identified the genetic architecture of the ethnic groups living in the corresponding country or suggested the genetic foundation of a social phenomenon. Genetic research has been conducted from epidemiological studies that previously described the health or disease conditions in defined population. This perspective summarizes national genome projects conducted in the past 10 years and introduces case studies to utilize genomic data in genetic research.

  17. Smart Gun Technology project. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Weiss, D.R.

    1996-05-01

    The goal of the Smart Gun Technology project is to eliminate the capability of an unauthorized user form firing a law officer`s firearm by implementing user-recognizing-and-authorizing (or {open_quotes}smart{close_quotes}) surety technologies. This project was funded by the National Institute of Justice. This report lists the findings and results of the project`s three primary objectives. First, to find and document the requirements for a smart firearm technology that law enforcement officers will value. Second, to investigate, evaluate, and prioritize technologies that meet the requirements for a law enforcement officer`s smart firearm. Third, to demonstrate and document the most promising technology`s usefulness in models of a smart firearm.

  18. Automated metadata--final project report

    International Nuclear Information System (INIS)

    Schissel, David

    2016-01-01

    This report summarizes the work of the Automated Metadata, Provenance Cataloging, and Navigable Interfaces: Ensuring the Usefulness of Extreme-Scale Data Project (MPO Project) funded by the United States Department of Energy (DOE), Offices of Advanced Scientific Computing Research and Fusion Energy Sciences. Initially funded for three years starting in 2012, it was extended for 6 months with additional funding. The project was a collaboration between scientists at General Atomics, Lawrence Berkley National Laboratory (LBNL), and Massachusetts Institute of Technology (MIT). The group leveraged existing computer science technology where possible, and extended or created new capabilities where required. The MPO project was able to successfully create a suite of software tools that can be used by a scientific community to automatically document their scientific workflows. These tools were integrated into workflows for fusion energy and climate research illustrating the general applicability of the project's toolkit. Feedback was very positive on the project's toolkit and the value of such automatic workflow documentation to the scientific endeavor.

  19. The Genome 10K Project: a way forward.

    Science.gov (United States)

    Koepfli, Klaus-Peter; Paten, Benedict; O'Brien, Stephen J

    2015-01-01

    The Genome 10K Project was established in 2009 by a consortium of biologists and genome scientists determined to facilitate the sequencing and analysis of the complete genomes of 10,000 vertebrate species. Since then the number of selected and initiated species has risen from ∼26 to 277 sequenced or ongoing with funding, an approximately tenfold increase in five years. Here we summarize the advances and commitments that have occurred by mid-2014 and outline the achievements and present challenges of reaching the 10,000-species goal. We summarize the status of known vertebrate genome projects, recommend standards for pronouncing a genome as sequenced or completed, and provide our present and future vision of the landscape of Genome 10K. The endeavor is ambitious, bold, expensive, and uncertain, but together the Genome 10K Consortium of Scientists and the worldwide genomics community are moving toward their goal of delivering to the coming generation the gift of genome empowerment for many vertebrate species.

  20. Project Execution Plan,Rev. 3; FINAL

    International Nuclear Information System (INIS)

    IT Corporation, Las Vegas

    2002-01-01

    This plan addresses project activities encompassed by the U.S. Department of Energy's (DOE's), National Nuclear Security Administration Nevada Operations Office, Environmental Restoration Division and conforms to the requirements contained in the Life-Cycle Asset Management, DOE Order 430.1A; The Joint Program Office Policy on Project Management in Support of DOE Order 430.1; Program and Project Management for the Acquisition of Capital Assets, DOE Order 413.3; the Project Execution and Engineering Management Planning Guide, GPG-FM-010; and other applicable Good Practice Guides; and the FY 2001 Integrated Planning, Accountability, and Budgeting System Policy Guidance. The plan also reflects the milestone philosophies of the Federal Facility Agreement and Consent Order, as agreed to by the State of Nevada, the DOE, and the U.S. Department of Defense; and traditional project management philosophies such as the development of life-cycle costs, schedules, and work scope; identification o f roles and responsibilities; and baseline management and controls

  1. EUDP Project: Low Noise Airfoil - Final Report

    DEFF Research Database (Denmark)

    This document summarizes the scientific results achieved during the EUDP-funded project `Low-Noise Airfoil'. The goals of this project are, on one side to develop a measurement technique that permits the evaluation of trailing edge noise in a classical aerodynamic wind tunnel, and on the other side...... to develop and implement a design procedure to manufacture airfoil profiles with low noise emission. The project involved two experimental campaigns: one in the LM Wind Power wind tunnel, a classical aerodynamic wind tunnel, in Lunderskov (DK), the second one in the Virginia Tech Stability Wind Tunnel....... In particular, the so-called TNO trailing edge noise model could be significantly improved by introducing turbulence anisotropy in its formulation, as well as the influence of the boundary layer mean pressure gradient. This two characteristics are inherent to airfoil flows but were neglected in the original...

  2. Los Alamos Science: The Human Genome Project. Number 20, 1992

    Science.gov (United States)

    Cooper, N. G.; Shea, N. eds.

    1992-01-01

    This document provides a broad overview of the Human Genome Project, with particular emphasis on work being done at Los Alamos. It tries to emphasize the scientific aspects of the project, compared to the more speculative information presented in the popular press. There is a brief introduction to modern genetics, including a review of classic work. There is a broad overview of the Genome Project, describing what the project is, what are some of its major five-year goals, what are major technological challenges ahead of the project, and what can the field of biology, as well as society expect to see as benefits from this project. Specific results on the efforts directed at mapping chromosomes 16 and 5 are discussed. A brief introduction to DNA libraries is presented, bearing in mind that Los Alamos has housed such libraries for many years prior to the Genome Project. Information on efforts to do applied computational work related to the project are discussed, as well as experimental efforts to do rapid DNA sequencing by means of single-molecule detection using applied spectroscopic methods. The article introduces the Los Alamos staff which are working on the Genome Project, and concludes with brief discussions on ethical, legal, and social implications of this work; a brief glimpse of genetics as it may be practiced in the next century; and a glossary of relevant terms.

  3. Los Alamos Science: The Human Genome Project. Number 20, 1992

    Energy Technology Data Exchange (ETDEWEB)

    Cooper, N G; Shea, N [eds.

    1992-01-01

    This article provides a broad overview of the Human Genome Project, with particular emphasis on work being done at Los Alamos. It tries to emphasize the scientific aspects of the project, compared to the more speculative information presented in the popular press. There is a brief introduction to modern genetics, including a review of classic work. There is a broad overview of the Genome Project, describing what the project is, what are some of its major five-year goals, what are major technological challenges ahead of the project, and what can the field of biology, as well as society expect to see as benefits from this project. Specific results on the efforts directed at mapping chromosomes 16 and 5 are discussed. A brief introduction to DNA libraries is presented, bearing in mind that Los Alamos has housed such libraries for many years prior to the Genome Project. Information on efforts to do applied computational work related to the project are discussed, as well as experimental efforts to do rapid DNA sequencing by means of single-molecule detection using applied spectroscopic methods. The article introduces the Los Alamos staff which are working on the Genome Project, and concludes with brief discussions on ethical, legal, and social implications of this work; a brief glimpse of genetics as it may be practiced in the next century; and a glossary of relevant terms.

  4. The impact of project marketing on the projects finality

    Directory of Open Access Journals (Sweden)

    Oxana SAVCIUC

    2015-06-01

    Full Text Available In the last years we assist at the level of the Republic of Moldova and also at international level at a trend to offer financial support with a special focus on project-based funding. Once with the appearance and development of the project concept, other related concepts are being developed such as project management or newly, we can also speak about the projects marketing. Until recently, the product marketing was intensely discussed; concepts such as services marketing appeared afterwards, but also the specific marketing for various branches, such as agromarketing, political marketing, etc. Given that fact that the projects are a product / service itself, at the moment, more and more often projects marketing is discussed.

  5. Project Ta-kos Outreach. Final Report.

    Science.gov (United States)

    Askew, Linda; And Others

    The Project Ta-kos Outreach program is an inservice training model designed to increase the probability that children (ages birth to 8) at risk for or with special needs and their families can access and receive appropriate services in order to remain an integral part of the community in which they reside. The program reflects an ecological…

  6. Maine Project against Bullying. Final Report.

    Science.gov (United States)

    Saufler, Chuck; Gagne, Cyndi

    Noting that bullying among primary school-age children has become recognized as an antecedent to more violent behavior in later grades, the 3-year Maine Project Against Bullying examined currently available research on bullying and evaluated books, curricula, media materials, and programs to identify resources and strategies which can be applied…

  7. Minewater heat recovery project. Final Technical report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1992-04-01

    This report consists of three sections: (1) Design, experimental testing and performance analysis of the 20-ft long DBHE (Downhole Bundle Heat Exchanger); (2) Modified design of mine water heat exchanger; and (3) Performance tests on mine water heat exchanger. Appendices summarize design calculations, discuss the scope of the work tasks, and present a diary of the progress throughout the research and development project.

  8. Automated metadata--final project report

    Energy Technology Data Exchange (ETDEWEB)

    Schissel, David [General Atomics, San Diego, CA (United States)

    2016-04-01

    This report summarizes the work of the Automated Metadata, Provenance Cataloging, and Navigable Interfaces: Ensuring the Usefulness of Extreme-Scale Data Project (MPO Project) funded by the United States Department of Energy (DOE), Offices of Advanced Scientific Computing Research and Fusion Energy Sciences. Initially funded for three years starting in 2012, it was extended for 6 months with additional funding. The project was a collaboration between scientists at General Atomics, Lawrence Berkley National Laboratory (LBNL), and Massachusetts Institute of Technology (MIT). The group leveraged existing computer science technology where possible, and extended or created new capabilities where required. The MPO project was able to successfully create a suite of software tools that can be used by a scientific community to automatically document their scientific workflows. These tools were integrated into workflows for fusion energy and climate research illustrating the general applicability of the project’s toolkit. Feedback was very positive on the project’s toolkit and the value of such automatic workflow documentation to the scientific endeavor.

  9. Human genome project: revolutionizing biology through leveraging technology

    Science.gov (United States)

    Dahl, Carol A.; Strausberg, Robert L.

    1996-04-01

    The Human Genome Project (HGP) is an international project to develop genetic, physical, and sequence-based maps of the human genome. Since the inception of the HGP it has been clear that substantially improved technology would be required to meet the scientific goals, particularly in order to acquire the complete sequence of the human genome, and that these technologies coupled with the information forthcoming from the project would have a dramatic effect on the way biomedical research is performed in the future. In this paper, we discuss the state-of-the-art for genomic DNA sequencing, technological challenges that remain, and the potential technological paths that could yield substantially improved genomic sequencing technology. The impact of the technology developed from the HGP is broad-reaching and a discussion of other research and medical applications that are leveraging HGP-derived DNA analysis technologies is included. The multidisciplinary approach to the development of new technologies that has been successful for the HGP provides a paradigm for facilitating new genomic approaches toward understanding the biological role of functional elements and systems within the cell, including those encoded within genomic DNA and their molecular products.

  10. The human genome project and the future of medical practice ...

    African Journals Online (AJOL)

    Contrary to the scepticism that characterised the planning stages of the human genome project, the technology and sequence data resulting from the project are set to revolutionise medical practice for good. The expected benefits include: enhanced discovery of disease genes, which will lead to improved knowledge on the ...

  11. Klickitat Cogeneration Project : Final Environmental Assessment.

    Energy Technology Data Exchange (ETDEWEB)

    United States. Bonneville Power Administration; Klickitat Energy Partners

    1994-09-01

    To meet BPA`s contractual obligation to supply electrical power to its customers, BPA proposes to acquire power generated by Klickitat Cogeneration Project. BPA has prepared an environmental assessment evaluating the proposed project. Based on the EA analysis, BPA`s proposed action is not a major Federal action significantly affecting the quality of the human environment within the meaning of the National Environmental Policy Act of 1969 for the following reasons: (1)it will not have a significant impact land use, upland vegetation, wetlands, water quality, geology, soils, public health and safety, visual quality, historical and cultural resources, recreation and socioeconomics, and (2) impacts to fisheries, wildlife resources, air quality, and noise will be temporary, minor, or sufficiently offset by mitigation. Therefore, the preparation of an environmental impact statement is not required and BPA is issuing this FONSI (Finding of No Significant Impact).

  12. Klickitat Cogeneration Project: Final environmental assessment

    International Nuclear Information System (INIS)

    1994-09-01

    To meet BPA's contractual obligation to supply electrical power to its customers, BPA proposes to acquire power generated by Klickitat Cogeneration Project. BPA has prepared an environmental assessment evaluating the proposed project. Based on the EA analysis, BPA's proposed action is not a major Federal action significantly affecting the quality of the human environment within the meaning of the National Environmental Policy Act of 1969 for the following reasons: (1)it will not have a significant impact land use, upland vegetation, wetlands, water quality, geology, soils, public health and safety, visual quality, historical and cultural resources, recreation and socioeconomics, and (2) impacts to fisheries, wildlife resources, air quality, and noise will be temporary, minor, or sufficiently offset by mitigation. Therefore, the preparation of an environmental impact statement is not required and BPA is issuing this FONSI (Finding of No Significant Impact)

  13. Final performance report for Project JEM

    Energy Technology Data Exchange (ETDEWEB)

    McKinney, M.J.; Jenkins, S.

    1997-12-31

    Project JEM (Jarvis Enhancement of Males) is a pre-college program directed toward stimulating disadvantaged, talented African American males in grades four, five, and six to attend college and major in mathematics, science, computer science, or related technical areas needed by the US Department of Energy. Twenty young African American male students were recruited from Gladewater Independent School District (ISD), Longview ISD, Hawkins ISD, Tyler ISD, Winona ISD and big Sandy ISD. Students enrolled in the program range from ages 10 to 13 and are in grades four, five and six. Student participants in the 1997 Project JEM Program attended Saturday Academy sessions and a four week intensive, summer residential program. The information here provides a synopsis of the activities which were conducted through each program component.

  14. Supercompaction/grouting demonstration project: Final report

    International Nuclear Information System (INIS)

    1987-01-01

    The purpose of this supercompaction demonstration project was to allow Martin Marietta Energy Systems, Inc. (The Company), to obtain cost analysis and performance information on volume reduction and waste encapsulation of solid, low-level contaminated waste (SLW). Ultimately, this information will be used to help define a waste disposal process for SLW that is acceptable to regulatory agencies and the US Department of Energy, Oak Ridge Operations (DOE/ORO). The technical objectives of the demonstration project were: (1) to obtain detailed performance data on each of the compacted barrels; (2) evaluate operating performance problems that may have occurred; (3) describe in detail the compaction and encapsulation process; and (4) to obtain operating cost data for the performance of this demonstration

  15. EuCARD final project report

    CERN Document Server

    Koutchouk, J P

    2014-01-01

    After four years of activity, EuCARD has most of its objectives fulfilled, with some new objectives added and a few others on excellent tracks while requiring additional time. The management has been active in reinforcing the collaborative links between partners and projects, contributing to the preparation of FP7-EuCARD2, initiating FP7-HiLumi-LHC Design Study, to favour sustained collaborations beyond EuCARD. An out-of-contract network has been successfully launched on laser plasma acceleration, to combine forces between accelerator, laser and plasma communities. Communication and dissemination activities have led to two highlights: Accelerating News, an accelerator R&D newsletter initiated by EuCARD and now common to all FP7 accelerator projects (over 1000 subscribers) and a series of monographs on accelerator sciences that is progressively finding its public. The scientific networks have more than fulfilled their initial objectives: roadmaps are defined for neutrino facilities, submitted to the Europe...

  16. 78 FR 26063 - Central Utah Project Completion Act; East Hobble Creek Restoration Project Final Environmental...

    Science.gov (United States)

    2013-05-03

    ...-100-00-0-0, CUPCA00] Central Utah Project Completion Act; East Hobble Creek Restoration Project Final... Creek Restoration Project. These two agencies have determined that the proposed [[Page 26064

  17. The Dust Management Project: Final Report

    Science.gov (United States)

    Hyatt, Mark J.; Straka, Sharon

    2011-01-01

    A return to the Moon to extend human presence, pursue scientific activities, use the Moon to prepare for future human missions to Mars, and expand Earth s economic sphere, will require investment in developing new technologies and capabilities to achieve affordable and sustainable human exploration. From the operational experience gained and lessons learned during the Apollo missions, conducting longterm operations in the lunar environment will be a particular challenge, given the difficulties presented by the unique physical properties and other characteristics of lunar regolith, including dust. The Apollo missions and other lunar explorations have identified significant lunar dust-related problems that will challenge future mission success. Comprised of regolith particles ranging in size from tens of nanometers to microns, lunar dust is a manifestation of the complex interaction of the lunar soil with multiple mechanical, electrical, and gravitational effects. The environmental and anthropogenic factors effecting the perturbation, transport, and deposition of lunar dust must be studied in order to mitigate it s potentially harmful effects on exploration systems and human explorers. The Dust Management Project (DMP) is tasked with the evaluation of lunar dust effects, assessment of the resulting risks, and development of mitigation and management strategies and technologies related to Exploration Systems architectures. To this end, the DMP supports the overall goal of the Exploration Technology Development Program (ETDP) of addressing the relevant high priority technology needs of multiple elements within the Constellation Program (CxP) and sister ETDP projects. Project scope, approach, accomplishments, summary of deliverables, and lessons learned are presented.

  18. Genomes to life project quarterly report June 2004.

    Energy Technology Data Exchange (ETDEWEB)

    Heffelfinger, Grant S.

    2005-01-01

    This SAND report provides the technical progress through June 2004 of the Sandia-led project, ''Carbon Sequestration in Synechococcus Sp.: From Molecular Machines to Hierarchical Modeling'', funded by the DOE Office of Science Genomes to Life Program. Understanding, predicting, and perhaps manipulating carbon fixation in the oceans has long been a major focus of biological oceanography and has more recently been of interest to a broader audience of scientists and policy makers. It is clear that the oceanic sinks and sources of CO{sub 2} are important terms in the global environmental response to anthropogenic atmospheric inputs of CO{sub 2} and that oceanic microorganisms play a key role in this response. However, the relationship between this global phenomenon and the biochemical mechanisms of carbon fixation in these microorganisms is poorly understood. In this project, we will investigate the carbon sequestration behavior of Synechococcus Sp., an abundant marine cyanobacteria known to be important to environmental responses to carbon dioxide levels, through experimental and computational methods. This project is a combined experimental and computational effort with emphasis on developing and applying new computational tools and methods. Our experimental effort will provide the biology and data to drive the computational efforts and include significant investment in developing new experimental methods for uncovering protein partners, characterizing protein complexes, identifying new binding domains. We will also develop and apply new data measurement and statistical methods for analyzing microarray experiments. Computational tools will be essential to our efforts to discover and characterize the function of the molecular machines of Synechococcus. To this end, molecular simulation methods will be coupled with knowledge discovery from diverse biological data sets for high-throughput discovery and characterization of protein-protein complexes

  19. Combined Final Report for Colony II Project

    Energy Technology Data Exchange (ETDEWEB)

    Kale, Laxmikant [University of Illinois; Jones, Terry [Oak Ridge National Laboratory; Moreira, Jose [IBM Corp.

    2013-10-23

    (This report was originally submmited by the lead PI (Terry Jones, ORNL) on October 22, 2013 to the program manager, Lucy Nowell. It is being submitted from University of Illinois in accordance with instructions). HPC Colony II seeks to provide portable performance for leadership class machines. Our strategy is based on adaptive system software that aims to make the intelligent decisions necessary to allow domain scientists to safely focus on their task at hand and allow the system software stack to adapt their application to the underlying architecture. This report describes the research undertaken towards these objectives and the results obtained over the performance period of the project.

  20. Emergency Fish Restoration Project; Final Report 2002.

    Energy Technology Data Exchange (ETDEWEB)

    LeCaire, Richard

    2003-03-01

    Lake Roosevelt is a 151-mile impoundment created by the construction of Grand Coulee Dam during the early 1940's. The construction of the dam permanently and forever blocked the once abundant anadromous fish runs to the upper Columbia Basin. Since the construction of Grand Coulee Dam in 1943 and Chief Joseph Dam in 1956 this area is known as the blocked area. The blocked area is totally dependant upon resident fish species to provide a subsistence, recreational and sport fishery. The sport fishery of lake Roosevelt is varied but consists mostly of Rainbow trout (Oncorhynchus mykiss), Kokanee salmon (Oncorhynchus nerka), Walleye (Stizostedion vitreum) Small mouth bass (Micropterus dolomieui) and white sturgeon (Acipenser transmontanus). Currently, Bonneville Power Administration funds and administers two trout/kokanee hatcheries on Lake Roosevelt. The Spokane Tribe of Indians operates one hatchery, the Washington Department of Fish and Wildlife the other. In addition to planting fish directly into Lake Roosevelt, these two hatcheries also supply fish to a net pen operation that also plants the lake. The net pen project is administered by Bonneville Power funded personnel but is dependant upon volunteer labor for daily feeding and monitoring operations. This project has demonstrated great success and is endorsed by the Colville Confederated Tribes, the Spokane Tribe of Indians, the Washington Department of Fish and Wildlife, local sportsmen associations, and the Lake Roosevelt Forum. The Lake Roosevelt/Grand Coulee Dam area is widely known and its diverse fishery is targeted by large numbers of anglers annually to catch rainbow trout, kokanee salmon, small mouth bass and walleye. These anglers contribute a great deal to the local economy by fuel, grocery, license, tackle and motel purchases. Because such a large portion of the local economy is dependant upon the Lake Roosevelt fishery and tourism, any unusual operation of the Lake Roosevelt system may have a

  1. The final recommendations of the ASIEPI project

    DEFF Research Database (Denmark)

    Thomsen, Kirsten Engelund; Rose, Jørgen; Aggerholm, Søren

    requirements; • impact, compliance and control of legislation; • effective handling of thermal bridges; • stimulation of good building and ductwork airtightness; • support for the market uptake for innovative systems; • stimulation of better summer comfort and efficient cooling. This report compiles the major...... findings and recommendations for each of these 6 topics. It also gives an overview of all other project materials, and thus helps the reader to quickly pinpoint the material most relevant to his/her question at any given time....

  2. Bear Creek Project. Final environmental statement

    International Nuclear Information System (INIS)

    1977-06-01

    The Bear Creek Project consists of certain mining and milling operations involving uranium ore deposits located in Converse County, Wyoming. Mining of uranium from nine known ore bodies will take place over a period of ten years (estimated); a mill with a nominal capacity of 1000 tons per day of ore will be constructed and operated as long as ore is available. The waste material (tailings) from the mill, also produced at a rate of about 1000 tons per day, will be stored onsite in an impoundment. Environmental impacts and adverse effects are summarized

  3. Cryogenic Barrier Demonstration Project. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Johnson, L.A.; Yarmak, E.; Long, E.L.

    2000-03-01

    A long-term frozen soil barrier was implemented at the HRE (Homogeneous Reactor Experiment) Pond facility at the Oak Ridge National Laboratory in 1997. This was performed to verify the technical feasibility and costs of deploying a frozen barrier at a radiologically contaminated site. Work began in September 1996 and progressed through to December 1999. The frozen barrier has been operational since November 1997. Verification of the barrier integrity was performed independently by the EPA's SITE Program. This project showed frozen barriers offer a proven technology to retain below grade hazardous substances at relatively low costs with minimal effect on the environment.

  4. Final Report. Montpelier District Energy Project

    Energy Technology Data Exchange (ETDEWEB)

    Baker, Jessie [City of Montpelier Vermont, Montpelier, VT (United States). Dept. of Public Works; Motyka, Kurt [City of Montpelier Vermont, Montpelier, VT (United States). Dept. of Public Works; Aja, Joe [State of Vermont, Montpelier, VT (United States). Dept. of Buildings and General Services; Garabedian, Harold T. [Energy & Environmental Analytics, Montpelier, VT (United States)

    2015-03-30

    The City of Montpelier, in collaboration with the State of Vermont, developed a central heat plant fueled with locally harvested wood-chips and a thermal energy distribution system. The project provides renewable energy to heat a complex of state buildings and a mix of commercial, private and municipal buildings in downtown Montpelier. The State of Vermont operates the central heat plant and the system to heat the connected state buildings. The City of Montpelier accepts energy from the central heat plant and operates a thermal utility to heat buildings in downtown Montpelier which elected to take heat from the system.

  5. Fairbanks Geothermal Energy Project Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Karl, Bernie [CHSR,LLC Owner

    2013-05-31

    The primary objective for the Fairbanks Geothermal Energy Project is to provide another source of base-load renewable energy in the Fairbanks North Star Borough (FNSB). To accomplish this, Chena Hot Springs Resort (Chena) drilled a re-injection well to 2700 feet and a production well to 2500 feet. The re-injection well allows a greater flow of water to directly replace the water removed from the warmest fractures in the geothermal reservoir. The new production will provide access to warmer temperature water in greater quantities.

  6. Final Report: Bone Mass Inheritance: A Project to Identify the Genetic Regulation of Bone Mass; FINAL

    International Nuclear Information System (INIS)

    Recker, Robert R. M.D.

    2002-01-01

    This project was designed to find human chromosomal locations that contain genes regulating peak bone density. It is part of a whole genome search for those loci,each responsible for at least 15% of the variation in the peak adult bone density. We accomplished this with a sib pair design, combined with simultaneous examination of extended kindreds. This project gave partial support of the recruitment which has now been completed. The project will extend into 2003. During the remainder of the project, a whole genome scan will be performed from the entire cohort of 2226 persons who have DNA archived, followed by linkage analysis. This project will meet the scientific objective leading eventually to expanded options for treating the condition that leads to bone thinning osteoporosis, and potential fractures in aging populations

  7. Final rapid reactivation project environmental assessment

    International Nuclear Information System (INIS)

    1999-01-01

    The US Department of Energy (DOE) has prepared an environmental assessment (EA) for the Rapid Reactivation Project at Sandia National Laboratories, New Mexico. The EA analyzes the potential effects of a proposal to increase production of neutron generators from the current capability of 600 units per year up to 2,000 units per year. The project would use existing buildings and infrastructure to the maximum extent possible to meet the additional production needs. The increased production levels would necessitate modifications and additions involving a total area of approximately 26,290 gross square feet at Sandia National Laboratories, New Mexico, Technical Area 1. Additional production equipment would be procured and installed. The no-action alternative would be to continue production activities at the current capability of 600 units per year. The EA analyzes effects on health, safety, and air quality, resulting from construction and operation and associated cumulative effects. A detailed description of the proposed action and its environmental consequences is presented in the EA

  8. Biorefinery Demonstration Project Final Progress Report

    Energy Technology Data Exchange (ETDEWEB)

    Lee, David [University of Georgia Research Foundation, Inc., Athens, GA (United States)

    2015-10-20

    In this project we focused on various aspects of biorefinery technology development including algal-biorefinery technology, thermochemical conversion of biomass to bio-oils and biochar; we tested characteristics and applications of biochars and evaluated nutrient cycling with wastewater treatment by the coupling of algal culture systems and anaerobic digestion. Key results include a method for reducing water content of bio-oil through atomized alcohol addition. The effect included increasing the pH and reducing the viscosity and cloud point of the bio-oil. Low input biochar production systems were evaluated via literature reviews and direct experimental work. Additionally, emissions were evaluated and three biochar systems were compared via a life cycle analysis. Attached growth systems for both algal cultivation and algal harvesting were found to be superior to suspended growth cultures. Nutrient requirements for algal cultivation could be obtained by the recycling of anaerobic digester effluents, thus experimentally showing that these two systems could be directly coupled. Twenty-two journal articles and six intellectual property applications resulted from the cumulative work that this project contributed to programmatically.

  9. Mock Site Licensing Demonstration Project. Final report

    International Nuclear Information System (INIS)

    Roop, R.D.

    1986-06-01

    The Mock Site Licensing Demonstration Project developed the Low-Level Radioactive Waste Siting Simulation, a role-playing exercise designed to facilitate the process of siting and licensing disposal facilities for low-level waste (LLW). This report describes the development, contant, and usefulness of the siting simulation. The simulation was designed by Harvard University's Program on Negotiation; it can be conducted at a workshop or conference, involves 14 or more participants, and requires about eight hours to complete. The simulation consists of two sessions. In the first, participants negotiate the selection of siting criteria, and in the second, a preferred site for a facility is chosen from three candidate sites. The project sponsored two workshops (in Boston, Massachusetts and Richmond, Virginia) in which the simulation was conducted for persons involved in planning for LLW. It is concluded that the siting simulation can be useful in three ways: (1) as a tool for information dissemination, (2) as a vehicle that can foste communication among parties in conflict, and (3) as a step toward consensus building and conflict resolution. The DOE National Low-Level Waste Management Program is now making the siting simulation available for use by states, regional compacts, and other organizations involved in development of LLW disposal facilities

  10. Advanced Blade Manufacturing Project - Final Report

    Energy Technology Data Exchange (ETDEWEB)

    POORE, ROBERT Z.

    1999-08-01

    The original scope of the project was to research improvements to the processes and materials used in the manufacture of wood-epoxy blades, conduct tests to qualify any new material or processes for use in blade design and subsequently build and test six blades using the improved processes and materials. In particular, ABM was interested in reducing blade cost and improving quality. In addition, ABM needed to find a replacement material for the mature Douglas fir used in the manufacturing process. The use of mature Douglas fir is commercially unacceptable because of its limited supply and environmental concerns associated with the use of mature timber. Unfortunately, the bankruptcy of FloWind in June 1997 and a dramatic reduction in AWT sales made it impossible for ABM to complete the full scope of work. However, sufficient research and testing were completed to identify several promising changes in the blade manufacturing process and develop a preliminary design incorporating these changes.

  11. TRUE Block Scale Continuation Project. Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Andersson, Peter; Byegaard, Johan [Geosigma AB (Sweden); Billaux, Daniel [Itasca Consultants SA (France); Cvetkovic, Vladimir [Royal Inst. of Technology, Stockholm (Sweden); Dershowitz, William; Doe, Thomas [Golder Associates Inc. (United States); Hermanson, Jan [Golder Associates AB (Sweden); Poteri, Antti [VTT (Finland); Tullborg, Eva-Lena [Terralogica AB (Sweden); Winberg, Anders [Conterra AB (SE)] (ed.)

    2007-03-15

    The TRUE Block Scale project was carried out during 1996-2002. This project focused on site characterisation and building of hydrostructural and microstructural models, sorbing tracer experiments in single structures and networks of structures over distances ranging between 1 and 100 m and also involved a unified application of various model approaches for modelling the in situ experiments. In 2002, ANDRA, Posiva, JNC and SKB decided to pursue some remaining issues in the so-called TRUE Block Scale Continuation project (TRUE BS2). The specific objectives of BS2 can be summarised as: 'Improve understanding of transport pathways at the block scale, including assessment of effects of geology and geometry, macrostructure and microstructure'. In order to cater to addressing the stated objective a series of hypotheses were formulated which explored the importance of geological information for predicting transport and retention and the possible differences between transport and retention between transport paths dominated by faults and those dominated by non-fault fractures (background fractures). In the process, prospects for carrying out experiments in fracture networks over longer distances (c 20-100 m) were explored. It was identified that experiments with sorbing tracers over these distances were prohibitive because of the time frames involved and the projected low mass recoveries. Instead the experimental locus was shifted to a geological structure previously not investigated by tracer tests in the TRUE Block Scale experiments. The lower immobile zone retention material properties assigned to background fractures compared to those assigned to the fault-type Structure 19 have been verified by means of back-calculations. The evaluated Type 1 flow path (Structure 19, Flow path I) retention material properties, as expressed by {kappa} parameter, are one order of magnitude higher than for the background fracture flow path. This finding is consistent with the

  12. Final project report for NEET pulsed ion beam project

    Energy Technology Data Exchange (ETDEWEB)

    Kucheyev, S. O. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2018-01-11

    The major goal of this project was to develop and demonstrate a novel experimental approach to access the dynamic regime of radiation damage formation in nuclear materials. In particular, the project exploited a pulsed-ion-beam method in order to gain insight into defect interaction dynamics by measuring effective defect interaction time constants and defect diffusion lengths. This project had the following four major objectives: (i) the demonstration of the pulsed ion beam method for a prototypical nuclear ceramic material, SiC; (ii) the evaluation of the robustness of the pulsed beam method from studies of defect generation rate effects; (iii) the measurement of the temperature dependence of defect dynamics and thermally activated defect-interaction processes by pulsed ion beam techniques; and (iv) the demonstration of alternative characterization techniques to study defect dynamics. As we describe below, all these objectives have been met.

  13. Yakima Fisheries Project. Final environmental impact statement

    International Nuclear Information System (INIS)

    1996-01-01

    BPA proposes to fund several fishery-related activities in the Yakima River Basin. These activities, known as the Yakima Fisheries Project (YFP), would be jointly managed by the State of Washington and the Yakima Indian Nation. The YFP is included in the Northwest Power Planning Council's (Council's) fish and wildlife program. The Council selected the Yakima River system for attention because fisheries resources are severely reduced from historical levels and because there is a significant potential for enhancement of these resources. BPA's proposed action is to fund (1) information gathering on the implementation of supplementation techniques and on feasibility of reintroducing coho salmon in an environment where native populations have become extinct; (2) research activities based on continuous assessment, feedback and improvement of research design and activities (open-quotes adaptive managementclose quotes); and (3) die construction, operation, and maintenance of facilities for supplementing populations of upper Yakima spring chinook salmon. Examined in addition to No Action are two alternatives for action: (1) supplementation of depressed natural populations of upper Yakima spring chinook and (2) that same supplementation plus a study to determine the feasibility of reestablishing naturally spawning population and a significant fall fishery for coho in the Yakima Basin. Alternative 2 is the preferred action. A central hatchery would be built for either alternative, as well as three sites with six raceways each for acclimation and release of spring chinook smolts. Major issues examined in the Revised Draft EIS include potential impacts of the project on genetic and ecological resources of existing fish populations, on water quality and quantity, on threatened and endangered species listed under the Endangered Species Act, and on the recreational fishery

  14. Yakima Fisheries Project : Final Environmental Impact Statement.

    Energy Technology Data Exchange (ETDEWEB)

    United States. Bonneville Power Administration; Washington (State). Dept. of Fish and Wildlife; Confederated Tribes and Bands of the Yakama Nation, Washington.

    1996-01-01

    BPA proposes to fund several fishery-related activities in the Yakima River Basin. These activities, known as the Yakima Fisheries Project (YFP), would be jointly managed by the State of Washington and the Yakima Indian Nation. The YFP is included in the Northwest Power Planning Council`s (Council`s) fish and wildlife program. The Council selected the Yakima River system for attention because fisheries resources are severely reduced from historical levels and because there is a significant potential for enhancement of these resources. BPA`s proposed action is to fund (1) information gathering on the implementation of supplementation techniques and on feasibility of reintroducing coho salmon in an environment where native populations have become extinct; (2) research activities based on continuous assessment, feedback and improvement of research design and activities ({open_quotes}adaptive management{close_quotes}); and (3) die construction, operation, and maintenance of facilities for supplementing populations of upper Yakima spring chinook salmon. Examined in addition to No Action are two alternatives for action: (1) supplementation of depressed natural populations of upper Yakima spring chinook and (2) that same supplementation plus a study to determine the feasibility of reestablishing naturally spawning population and a significant fall fishery for coho in the Yakima Basin. Alternative 2 is the preferred action. A central hatchery would be built for either alternative, as well as three sites with six raceways each for acclimation and release of spring chinook smolts. Major issues examined in the Revised Draft EIS include potential impacts of the project on genetic and ecological resources of existing fish populations, on water quality and quantity, on threatened and endangered species listed under the Endangered Species Act, and on the recreational fishery.

  15. Ice Load Project Final Technical Report

    Energy Technology Data Exchange (ETDEWEB)

    McCoy, Timothy J. [DNV GL, Seattle, WA (United States); Brown, Thomas [IFC Engineering, Calgary, AB (Canada); Byrne, Alex [DNV GL, Seattle, WA (United States)

    2014-10-30

    As interest and investment in offshore wind projects increase worldwide, some turbines will be installed in locations where ice of significant thickness forms on the water surface. This ice moves under the driving forces of wind, current, and thermal effects and may result in substantial forces on bottom-fixed support structures. The North and Baltic Seas in Europe have begun to see significant wind energy development and the Great Lakes of the United States and Canada may host wind energy development in the near future. Design of the support structures for these projects is best performed through the use of an integrated tool that can calculate the cumulative effects of forces due to turbine operations, wind, waves, and floating ice. The dynamic nature of ice forces requires that these forces be included in the design simulations, rather than added as static forces to simulation results. The International Electrotechnical Commission (IEC) standard[2] for offshore wind turbine design and the International Organization for Standardization (ISO) standard[3] for offshore structures provide requirements and algorithms for the calculation of forces induced by surface ice; however, currently none of the major wind turbine dynamic simulation codes provides the ability to model ice loads. The scope of work of the project described in this report includes the development of a suite of subroutines, collectively named IceFloe, that meet the requirements of the IEC and ISO standards and couples with four of the major wind turbine dynamic simulation codes. The mechanisms by which ice forces impinge on offshore structures generally include the forces required for crushing of the ice against vertical-sided structures and the forces required to fracture the ice as it rides up on conical-sided structures. Within these two broad categories, the dynamic character of the forces with respect to time is also dependent on other factors such as the velocity and thickness of the moving ice

  16. WSF Biodiesel Demonstration Project Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Washington State University; University of Idaho; The Glosten Associates, Inc.; Imperium Renewables, Inc.

    2009-04-30

    In 2004, WSF canceled a biodiesel fuel test because of “product quality issues” that caused the fuel purifiers to clog. The cancelation of this test and the poor results negatively impacted the use of biodiesel in marine application in the Pacific Northwest. In 2006, The U.S. Department of Energy awarded the Puget Sound Clean Air Agency a grant to manage a scientific study investigating appropriate fuel specifications for biodiesel, fuel handling procedures and to conduct a fuel test using biodiesel fuels in WSF operations. The Agency put together a project team comprised of experts in fields of biodiesel research and analysis, biodiesel production, marine engineering and WSF personnel. The team reviewed biodiesel technical papers, reviewed the 2004 fuel test results, designed a fuel test plan and provided technical assistance during the test. The research reviewed the available information on the 2004 fuel test and conducted mock laboratory experiments, but was not able to determine why the fuel filters clogged. The team then conducted a literature review and designed a fuel test plan. The team implemented a controlled introduction of biodiesel fuels to the test vessels while monitoring the environmental conditions on the vessels and checking fuel quality throughout the fuel distribution system. The fuel test was conducted on the same three vessels that participated in the canceled 2004 test using the same ferry routes. Each vessel used biodiesel produced from a different feedstock (i.e. soy, canola and yellow grease). The vessels all ran on ultra low sulfur diesel blended with biodiesel. The percentage of biodiesel was incrementally raised form from 5 to 20 percent. Once the vessels reached the 20 percent level, they continued at this blend ratio for the remainder of the test. Fuel samples were taken from the fuel manufacturer, during fueling operations and at several points onboard each vessel. WSF Engineers monitored the performance of the fuel systems and

  17. Big data in energy. Final project

    International Nuclear Information System (INIS)

    Fraysse, Clemence; Plaisance, Brice

    2015-01-01

    Within the context of development of the use of always more abundant digital data in energy production, distribution and consumption networks, for instance as real time input of Smart Grids, the authors propose a description of the present energy sector, of its recent evolutions, of its actors and of its future challenges. They focus on the case of France, but also make reference to other countries where these evolutions of the energy sector are already further advanced. They discuss the evolutions generated by the emergence of the Bid Data on the whole value chain. They also discuss the various challenges associated with these transformations, notably for energy transition, for a better integration of renewable energies into the national energy grid, but also in terms of emergence of an energy related data services sector, and in terms of upheaval of business models. They finally discuss the various obstacles that the Big Data revolution will have to face and overcome to deeply transform the energy sector, notably the risk of a malevolent use of data, and of a loss of confidence from the consumer

  18. Genomes to Life Project Quartely Report October 2004.

    Energy Technology Data Exchange (ETDEWEB)

    Heffelfinger, Grant S.; Martino, Anthony; Rintoul, Mark Daniel; Geist, Al; Gorin, Andrey; Xu, Ying; Palenik, Brian

    2005-02-01

    a set of novel capabilities for inference of regulatory pathways in microbial genomes across multiple sources of information through the integration of computational and experimental technologies. These capabilities will be applied to Synechococcus regulatory pathways to characterize their interaction map and identify component proteins in these - 4 - pathways. We will also investigate methods for combining experimental and computational results with visualization and natural language tools to accelerate discovery of regulatory pathways. The ultimate goal of this effort is develop and apply new experimental and computational methods needed to generate a new level of understanding of how the Synechococcus genome affects carbon fixation at the global scale. Anticipated experimental and computational methods will provide ever-increasing insight about the individual elements and steps in the carbon fixation process, however relating an organism's genome to its cellular response in the presence of varying environments will require systems biology approaches. Thus a primary goal for this effort is to integrate the genomic data generated from experiments and lower level simulations with data from the existing body of literature into a whole cell model. We plan to accomplish this by developing and applying a set of tools for capturing the carbon fixation behavior of complex of Synechococcus at different levels of resolution. Finally, the explosion of data being produced by high-throughput experiments requires data analysis and models which are more computationally complex, more heterogeneous, and require coupling to ever increasing amounts of experimentally obtained data in varying formats. These challenges are unprecedented in high performance scientific computing and necessitate the development of a companion computational infrastructure to support this effort. More information about this project, including a copy of the original proposal, can be found at www.genomes

  19. Project monitor. Final report. [Allegheny County, PA

    Energy Technology Data Exchange (ETDEWEB)

    Hammond, P.Y.; Beck, P.; Doctors, S.I.

    1979-04-27

    Results are reported of a study of consumers' energy attitudes and behavior. Household consumers and small business consumers (both retail and manufacturing) responded to the survey, but only the household results are reported. The study sought to understand energy-related behavior at the level where the various components of energy policy intersect. Attempts are made to attain this goal by determining the extent to which various properties of the individuals and firms are associated with various amounts of conservation. A representative sample of the adult population in Allegheny County, Pennsylvania was interviewed. Part I introduces the measures of household conservation to be used in the survey. Part II analyzes each of the types of energy conservation - general, winterization, heating, cooling, appliance, transportation, and electricity reductions - and relates them to demographic, situation, attitudinal, and perceptual variables in the household sample. Part III deals with the impacts of Project Pacesetter and the United Mine Workers' strike against the coal operators - particularly, the impact of the coal strike on household residents of Allegheny County. Part IV summarizes the findings and uses them for recommendations regarding energy conservation policy. Additional data are presented in 4 appendices. (MCW)

  20. Project BioLex. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Dahl, J.; Broechner Andersen, M.; FORCE Technology

    2007-01-15

    The usage of biomass as a renewable source of energy is an important issue for a sustainable energy supply in Denmark. Due to pioneering work, Denmark has great experience in producing energy from biomass both in large scale CHP utilities as well as in small scale application such as domestic heating. This experience has been mainly focused in the usage of traditional domestic solid biomass fuels such as wood. However, the limited amounts available of these fuels and thereby following increasing prices have triggered the interest in using other sources of biomass. Rest and waste products from the agricultural industry is one examples of biomass which has a large potential to be used as a cheap biomass fuels. Projects of using these new types of biomass fuels are often hindered by insecurity whether this new biomass source can be applied as fuel or not. Thus in order to support usage of new sources of biomass a first step is to have knowledge on properties of the biomass fuel and be able to compare these to the known traditional fuels used. The BioLex was designed to provide this information about important properties of both traditional Danish as well as new more exotic solid biomass fuels in a database available to the public via the internet. (au)

  1. Borehole project - Final report of phase 3

    International Nuclear Information System (INIS)

    Pusch, R.; Ramqvist, G.

    2008-03-01

    The report describes borehole plugging techniques for use in deep boreholes extending from the ground surface, and construction and placement of plugs in holes of different lengths and orientations bored from the repository rooms. The principle employed is the one proposed in earlier phases of the project, i.e. to tightly seal those parts of boreholes where the rock has few fractures and a low hydraulic conductivity, and filling of those parts that intersect water-bearing fracture zones with physically stable material that does not need to be low-permeable. Four methods for tight plugging have been identified and tested and a technique has been found for filling boreholes that are intersected by fracture zones. The upper end of boreholes extending from the ground surface needs a 'mechanical' seal for which copper metal and concrete work well. The experience from plugging of a 550 m deep borehole at Olkiluoto (OL-KR24) has been compiled and plans worked out for sampling and testing of contacting clay and concrete in this hole and in short holes in the Aespoe URL. (orig.)

  2. Harvard Personal Genome Project: lessons from participatory public research

    Science.gov (United States)

    2014-01-01

    Background Since its initiation in 2005, the Harvard Personal Genome Project has enrolled thousands of volunteers interested in publicly sharing their genome, health and trait data. Because these data are highly identifiable, we use an ‘open consent’ framework that purposefully excludes promises about privacy and requires participants to demonstrate comprehension prior to enrollment. Discussion Our model of non-anonymous, public genomes has led us to a highly participatory model of researcher-participant communication and interaction. The participants, who are highly committed volunteers, self-pursue and donate research-relevant datasets, and are actively engaged in conversations with both our staff and other Personal Genome Project participants. We have quantitatively assessed these communications and donations, and report our experiences with returning research-grade whole genome data to participants. We also observe some of the community growth and discussion that has occurred related to our project. Summary We find that public non-anonymous data is valuable and leads to a participatory research model, which we encourage others to consider. The implementation of this model is greatly facilitated by web-based tools and methods and participant education. Project results are long-term proactive participant involvement and the growth of a community that benefits both researchers and participants. PMID:24713084

  3. Harvard Personal Genome Project: lessons from participatory public research.

    Science.gov (United States)

    Ball, Madeleine P; Bobe, Jason R; Chou, Michael F; Clegg, Tom; Estep, Preston W; Lunshof, Jeantine E; Vandewege, Ward; Zaranek, Alexander; Church, George M

    2014-02-28

    Since its initiation in 2005, the Harvard Personal Genome Project has enrolled thousands of volunteers interested in publicly sharing their genome, health and trait data. Because these data are highly identifiable, we use an 'open consent' framework that purposefully excludes promises about privacy and requires participants to demonstrate comprehension prior to enrollment. Our model of non-anonymous, public genomes has led us to a highly participatory model of researcher-participant communication and interaction. The participants, who are highly committed volunteers, self-pursue and donate research-relevant datasets, and are actively engaged in conversations with both our staff and other Personal Genome Project participants. We have quantitatively assessed these communications and donations, and report our experiences with returning research-grade whole genome data to participants. We also observe some of the community growth and discussion that has occurred related to our project. We find that public non-anonymous data is valuable and leads to a participatory research model, which we encourage others to consider. The implementation of this model is greatly facilitated by web-based tools and methods and participant education. Project results are long-term proactive participant involvement and the growth of a community that benefits both researchers and participants.

  4. Innovative subsurface stabilization project -- Final Report

    International Nuclear Information System (INIS)

    Loomis, G.G.; Zdinak, A.P.; Bishop, C.W.

    1996-11-01

    This is a report of results of applying four innovative grouting materials and one commercially available material for creating monoliths out of buried waste sites using jet grouting. The four innovative materials included a proprietary water-based epoxy, an Idaho National Engineering Laboratory-developed two-component grout that resembles hematite when cured with soil, molten low-temperature paraffin, and a proprietary iron oxide cement-based grout called TECT. The commercial grout was Type-H high-sulfate-resistant cement. These materials were tested in specially designed cold test pits that simulate buried transuranic waste at the Idaho National Engineering Laboratory. In addition to the grouting studies, specially designed field-scale permeameters were constructed to perform full-scale controlled mass balance hydraulic conductivity studies. An ungrouted field-scale permeameter contained simulated buried waste and soil and was left ungrouted, and a second identical field-scale permeameter was grouted with commercial-grade Type-H cement. The field demonstrations were performed in an area referred to as the Cold Test Pit at the Idaho National Engineering Laboratory. The Cold Test Pit is adjacent to the laboratory's Radioactive Waste Management Complex. At the complex, 2 million ft 3 of transuranic waste is commingled with 6--8 million ft 3 of soil in shallow land burial, and improving the confinement of this waste is one of the options for final waste disposition. This report gives results of grouting, coring, hydraulic conductivity, and destructive examination of the grouted buried waste matrix

  5. Colorado Better Buildings Project. Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Strife, Susie [Boulder County, Boulder, CO (United States); Yancey, Lea [Boulder County, Boulder, CO (United States)

    2013-12-30

    The Colorado Better Buildings project intended to bring new and existing energy efficiency model programs to market with regional collaboration and funding partnerships. The goals for Boulder County and its program partners were to advance energy efficiency investments, stimulate economic growth in Colorado and advance the state’s energy independence. Collectively, three counties set out to complete 9,025 energy efficiency upgrades in 2.5 years and they succeeded in doing so. Energy efficiency upgrades have been completed in more than 11,000 homes and businesses in these communities. Boulder County and its partners received a $25 million BetterBuildings grant from the U.S. Department of Energy under the American Recovery and Reinvestment Act in the summer of 2010. This was also known as the Energy Efficiency and Conservation Block Grants program. With this funding, Boulder County, the City and County of Denver, and Garfield County set out to design programs for the residential and commercial sectors to overcome key barriers in the energy upgrade process. Since January 2011, these communities have paired homeowners and business owners with an Energy Advisor – an expert to help move from assessment to upgrade with minimal hassle. Pairing this step-by-step assistance with financing incentives has effectively addressed many key barriers, resulting in energy efficiency improvements and happy customers. An expert energy advisor guides the building owner through every step of the process, coordinating the energy assessment, interpreting results for a customized action plan, providing a list of contractors, and finding and applying for all available rebates and low-interest loans. In addition to the expert advising and financial incentives, the programs also included elements of social marketing, technical assistance, workforce development and contractor trainings, project monitoring and verification, and a cloud-based customer data system to coordinate among field

  6. The human Genome project and the future of oncology

    International Nuclear Information System (INIS)

    Collins, Francis S.

    1996-01-01

    The Human Genome Project is an ambitious 15-year effort to devise maps and sequence of the 3-billion base pair human genome, including all 100,000 genes. The project is running ahead of schedule and under budget. Already the effects on progress in disease gene discovery have been dramatic, especially for cancer. The most appropriate uses of susceptibility testing for breast, ovarian, and colon cancer are being investigated in research protocols, and the need to prevent genetic discrimination in employment and health insurance is becoming more urgent. In the longer term, these gene discoveries are likely to usher in a new era of therapeutic molecular medicine

  7. Alignment of 1000 Genomes Project reads to reference assembly GRCh38.

    Science.gov (United States)

    Zheng-Bradley, Xiangqun; Streeter, Ian; Fairley, Susan; Richardson, David; Clarke, Laura; Flicek, Paul

    2017-07-01

    The 1000 Genomes Project produced more than 100 trillion basepairs of short read sequence from more than 2600 samples in 26 populations over a period of five years. In its final phase, the project released over 85 million genotyped and phased variants on human reference genome assembly GRCh37. An updated reference assembly, GRCh38, was released in late 2013, but there was insufficient time for the final phase of the project analysis to change to the new assembly. Although it is possible to lift the coordinates of the 1000 Genomes Project variants to the new assembly, this is a potentially error-prone process as coordinate remapping is most appropriate only for non-repetitive regions of the genome and those that did not see significant change between the two assemblies. It will also miss variants in any region that was newly added to GRCh38. Thus, to produce the highest quality variants and genotypes on GRCh38, the best strategy is to realign the reads and recall the variants based on the new alignment. As the first step of variant calling for the 1000 Genomes Project data, we have finished remapping all of the 1000 Genomes sequence reads to GRCh38 with alternative scaffold-aware BWA-MEM. The resulting alignments are available as CRAM, a reference-based sequence compression format. The data have been released on our FTP site and are also available from European Nucleotide Archive to facilitate researchers discovering variants on the primary sequences and alternative contigs of GRCh38. © The Authors 2017. Published by Oxford University Press.

  8. Sequencing of a new target genome: the Pediculus humanus humanus (Phthiraptera: Pediculidae) genome project.

    Science.gov (United States)

    Pittendrigh, B R; Clark, J M; Johnston, J S; Lee, S H; Romero-Severson, J; Dasch, G A

    2006-11-01

    The human body louse, Pediculus humanus humanus (L.), and the human head louse, Pediculus humanus capitis, belong to the hemimetabolous order Phthiraptera. The body louse is the primary vector that transmits the bacterial agents of louse-borne relapsing fever, trench fever, and epidemic typhus. The genomes of the bacterial causative agents of several of these aforementioned diseases have been sequenced. Thus, determining the body louse genome will enhance studies of host-vector-pathogen interactions. Although not important as a major disease vector, head lice are of major social concern. Resistance to traditional pesticides used to control head and body lice have developed. It is imperative that new molecular targets be discovered for the development of novel compounds to control these insects. No complete genome sequence exists for a hemimetabolous insect species primarily because hemimetabolous insects often have large (2000 Mb) to very large (up to 16,300 Mb) genomes. Fortuitously, we determined that the human body louse has one of the smallest genome sizes known in insects, suggesting it may be a suitable choice as a minimal hemimetabolous genome in which many genes have been eliminated during its adaptation to human parasitism. Because many louse species infest birds and mammals, the body louse genome-sequencing project will facilitate studies of their comparative genomics. A 6-8X coverage of the body louse genome, plus sequenced expressed sequence tags, should provide the entomological, evolutionary biology, medical, and public health communities with useful genetic information.

  9. Final Technical Report. Project Boeing SGS

    Energy Technology Data Exchange (ETDEWEB)

    Bell, Thomas E. [The Boeing Company, Seattle, WA (United States)

    2014-12-31

    Boeing and its partner, PJM Interconnection, teamed to bring advanced “defense-grade” technologies for cyber security to the US regional power grid through demonstration in PJM’s energy management environment. Under this cooperative project with the Department of Energy, Boeing and PJM have developed and demonstrated a host of technologies specifically tailored to the needs of PJM and the electric sector as a whole. The team has demonstrated to the energy industry a combination of processes, techniques and technologies that have been successfully implemented in the commercial, defense, and intelligence communities to identify, mitigate and continuously monitor the cyber security of critical systems. Guided by the results of a Cyber Security Risk-Based Assessment completed in Phase I, the Boeing-PJM team has completed multiple iterations through the Phase II Development and Phase III Deployment phases. Multiple cyber security solutions have been completed across a variety of controls including: Application Security, Enhanced Malware Detection, Security Incident and Event Management (SIEM) Optimization, Continuous Vulnerability Monitoring, SCADA Monitoring/Intrusion Detection, Operational Resiliency, Cyber Range simulations and hands on cyber security personnel training. All of the developed and demonstrated solutions are suitable for replication across the electric sector and/or the energy sector as a whole. Benefits identified include; Improved malware and intrusion detection capability on critical SCADA networks including behavioral-based alerts resulting in improved zero-day threat protection; Improved Security Incident and Event Management system resulting in better threat visibility, thus increasing the likelihood of detecting a serious event; Improved malware detection and zero-day threat response capability; Improved ability to systematically evaluate and secure in house and vendor sourced software applications; Improved ability to continuously monitor

  10. Final report on the maintenance asset management project : phase II.

    Science.gov (United States)

    2013-07-01

    Iowa Department of Transportation (IA DOT) is finalizing research to streamline field inventory/inspection of culverts by Maintenance and Construction staff while maximizing the use of tablet technologies. The project began in 2011 to develop some ne...

  11. Final Report on Atomic Database Project

    International Nuclear Information System (INIS)

    Yuan, J.; Gui, Z.; Moses, G.A.

    2006-01-01

    Atomic physics in hot dense plasmas is essential for understanding the radiative properties of plasmas either produced terrestrially such as in fusion energy research or in space such as the study of the core of the sun. Various kinds of atomic data are needed for spectrum analysis or for radiation hydrodynamics simulations. There are many atomic databases accessible publicly through the web, such as CHIANTI (an atomic database for spectroscopic diagnostics for astrophysical plasmas) from Naval Research Laboratory [1], collaborative development of TOPbase (The Opacity Project for astrophysically abundant elements) [2], NIST atomic spectra database from NIST [3], TOPS Opacities from Los Alamos National Laboratory [4], etc. Most of these databases are specific to astrophysics, which provide energy levels, oscillator strength f and photoionization cross sections for astrophysical elements ( Z=1-26). There are abundant spectrum data sources for spectral analysis of low Z elements. For opacities used for radiation transport, TOPS Opacities from LANL is the most valuable source. The database provides mixed opacities from element for H (Z=1) to Zn (Z=30) The data in TOPS Opacities is calculated by the code LEDCOP. In the Fusion Technology Institute, we also have developed several different models to calculate atomic data and opacities, such as the detailed term accounting model (DTA) and the unresolved transition array (UTA) model. We use the DTA model for low-Z materials since an enormous number of transitions need to be computed for medium or high-Z materials. For medium and high Z materials, we use the UTA model which simulates the enormous number of transitions by using a single line profile to represent a collection of transition arrays. These models have been implemented in our computing code JATBASE and RSSUTA. For plasma populations, two models are used in JATBASE, one is the local thermodynamic equilibrium (LTE) model and the second is the non-LTE model. For the

  12. Final Project Report Project 10749-4.2.2.1 2007-2009

    Energy Technology Data Exchange (ETDEWEB)

    Zacher, Alan H.; Holladay, Johnathan E.; Frye, J. G.; Brown, Heather M.; Santosa, Daniel M.; Oberg, Aaron A.

    2009-05-11

    This is the final report for the DOE Project 10749-4.2.2.1 for the FY2007 - FY2009 period. This report is non-proprietary, and will be submitted to DOE as a final project report. The report covers activities under the DOE Project inside CRADA 269 (Project 53231) as well as project activites outside of that CRADA (Project 56662). This is the final report that is summarized from the non-proprietary quarterlies submitted to DOE over the past 2.5 years, which in turn are summaries from the proprietary technical reporting to UOP.

  13. Freedom and Responsibility in Synthetic Genomics: The Synthetic Yeast Project.

    Science.gov (United States)

    Sliva, Anna; Yang, Huanming; Boeke, Jef D; Mathews, Debra J H

    2015-08-01

    First introduced in 2011, the Synthetic Yeast Genome (Sc2.0) PROJECT is a large international synthetic genomics project that will culminate in the first eukaryotic cell (Saccharomyces cerevisiae) with a fully synthetic genome. With collaborators from across the globe and from a range of institutions spanning from do-it-yourself biology (DIYbio) to commercial enterprises, it is important that all scientists working on this project are cognizant of the ethical and policy issues associated with this field of research and operate under a common set of principles. In this commentary, we survey the current ethics and regulatory landscape of synthetic biology and present the Sc2.0 Statement of Ethics and Governance to which all members of the project adhere. This statement focuses on four aspects of the Sc2.0 PROJECT: societal benefit, intellectual property, safety, and self-governance. We propose that such project-level agreements are an important, valuable, and flexible model of self-regulation for similar global, large-scale synthetic biology projects in order to maximize the benefits and minimize potential harms. Copyright © 2015 by the Genetics Society of America.

  14. Reconsidering democracy. History of the Human Genome Project.

    NARCIS (Netherlands)

    Marli Huijer

    2003-01-01

    What options are open for people—citizens, politicians, and other nonscientists—to become actively involved in and anticipate new directions in the life sciences? In addressing this question, this article focuses on the start of the Human Genome Project (1985-1990). By contrasting various models of

  15. The Human Genome Project: Biology, Computers, and Privacy.

    Science.gov (United States)

    Cutter, Mary Ann G.; Drexler, Edward; Gottesman, Kay S.; Goulding, Philip G.; McCullough, Laurence B.; McInerney, Joseph D.; Micikas, Lynda B.; Mural, Richard J.; Murray, Jeffrey C.; Zola, John

    This module, for high school teachers, is the second of two modules about the Human Genome Project (HGP) produced by the Biological Sciences Curriculum Study (BSCS). The first section of this module provides background information for teachers about the structure and objectives of the HGP, aspects of the science and technology that underlie the…

  16. Reconsidering democracy - History of the human genome project

    NARCIS (Netherlands)

    Huijer, M

    What options are open for people-citizens, politicians, and other nonscientists-to become actively involved in and anticipate new directions in the life sciences? In addressing this question, this article focuses on the start of the Human Genome Project (1985-1990). By contrasting various models of

  17. Enhancing Biology Instruction with the Human Genome Project

    Science.gov (United States)

    Buxeda, Rosa J.; Moore-Russo, Deborah A.

    2003-01-01

    The Human Genome Project (HGP) is a recent scientific milestone that has received notable attention. This article shows how a biology course is using the HGP to enhance students' experiences by providing awareness of cutting edge research, with information on new emerging career options, and with opportunities to consider ethical questions raised…

  18. Comparing genetic variants detected in the 1000 genomes project ...

    Indian Academy of Sciences (India)

    Single-nucleotide polymorphisms (SNPs) determined based on SNP arrays from the international HapMap consortium (HapMap) and the genetic variants detected in the 1000 genomes project (1KGP) can serve as two references for genomewide association studies (GWAS). We conducted comparative analyses to provide ...

  19. Mapping our genes: The genome projects: How big, how fast

    Energy Technology Data Exchange (ETDEWEB)

    none,

    1988-04-01

    For the past 2 years, scientific and technical journals in biology and medicine have extensively covered a debate about whether and how to determine the function and order of human genes on human chromosomes and when to determine the sequence of molecular building blocks that comprise DNA in those chromosomes. In 1987, these issues rose to become part of the public agenda. The debate involves science, technology, and politics. Congress is responsible for /open quotes/writing the rules/close quotes/ of what various federal agencies do and for funding their work. This report surveys the points made so far in the debate, focusing on those that most directly influence the policy options facing the US Congress. Congressional interest focused on how to assess the rationales for conducting human genome projects, how to fund human genome projects (at what level and through which mechanisms), how to coordinate the scientific and technical programs of the several federal agencies and private interests already supporting various genome projects, and how to strike a balance regarding the impact of genome projects on international scientific cooperation and international economic competition in biotechnology. OTA prepared this report with the assistance of several hundred experts throughout the world. 342 refs., 26 figs., 11 tabs.

  20. Mapping Our Genes: The Genome Projects: How Big, How Fast

    Science.gov (United States)

    1988-04-01

    For the past 2 years, scientific and technical journals in biology and medicine have extensively covered a debate about whether and how to determine the function and order of human genes on human chromosomes and when to determine the sequence of molecular building blocks that comprise DNA in those chromosomes. In 1987, these issues rose to become part of the public agenda. The debate involves science, technology, and politics. Congress is responsible for ?writing the rules? of what various federal agencies do and for funding their work. This report surveys the points made so far in the debate, focusing on those that most directly influence the policy options facing the US Congress. Congressional interest focused on how to assess the rationales for conducting human genome projects, how to fund human genome projects (at what level and through which mechanisms), how to coordinate the scientific and technical programs of the several federal agencies and private interests already supporting various genome projects, and how to strike a balance regarding the impact of genome projects on international scientific cooperation and international economic competition in biotechnology. The Office of Technology Assessment (OTA) prepared this report with the assistance of several hundred experts throughout the world.

  1. 76 FR 57729 - Boundary Hydroelectric Project; Sullivan Creek Project; Notice of Availability of the Final...

    Science.gov (United States)

    2011-09-16

    ...-015] Boundary Hydroelectric Project; Sullivan Creek Project; Notice of Availability of the Final Environmental Impact Statement for the Relicensing of the Boundary Hydroelectric Project and the Surrender of... reviewed the applications for license for the Boundary Hydroelectric Project (FERC No. 2144-38), and the...

  2. Toward an Integrated BAC Library Resource for Genome Sequencing and Analysis; FINAL

    International Nuclear Information System (INIS)

    Simon, M. I.; Kim, U.-J.

    2002-01-01

    We developed a great deal of expertise in building large BAC libraries from a variety of DNA sources including humans, mice, corn, microorganisms, worms, and Arabidopsis. We greatly improved the technology for screening these libraries rapidly and for selecting appropriate BACs and mapping BACs to develop large overlapping contigs. We became involved in supplying BACs and BAC contigs to a variety of sequencing and mapping projects and we began to collaborate with Drs. Adams and Venter at TIGR and with Dr. Leroy Hood and his group at University of Washington to provide BACs for end sequencing and for mapping and sequencing of large fragments of chromosome 16. Together with Dr. Ian Dunham and his co-workers at the Sanger Center we completed the mapping and they completed the sequencing of the first human chromosome, chromosome 22. This was published in Nature in 1999 and our BAC contigs made a major contribution to this sequencing effort. Drs. Shizuya and Ding invented an automated highly accurate BAC mapping technique. We also developed long-term collaborations with Dr. Uli Weier at UCSF in the design of BAC probes for characterization of human tumors and specific chromosome deletions and breakpoints. Finally the contribution of our work to the human genome project has been recognized in the publication both by the international consortium and the NIH of a draft sequence of the human genome in Nature last year. Dr. Shizuya was acknowledged in the authorship of that landmark paper. Dr. Simon was also an author on the Venter/Adams Celera project sequencing the human genome that was published in Science last year

  3. Coordinated international action to accelerate genome-to-phenome with FAANG, the Functional Annotation of Animal Genomes project : open letter

    NARCIS (Netherlands)

    Archibald, A.L.; Bottema, C.D.; Brauning, R.; Burgess, S.C.; Burt, D.W.; Casas, E.; Cheng, H.H.; Clarke, L.; Couldrey, C.; Dalrymple, B.P.; Elsik, C.G.; Foissac, S.; Giuffra, E.; Groenen, M.A.M.; Hayes, B.J.; Huang, L.S.; Khatib, H.; Kijas, J.W.; Kim, H.; Lunney, J.K.; McCarthy, F.M.; McEwan, J.; Moore, S.; Nanduri, B.; Notredame, C.; Palti, Y.; Plastow, G.S.; Reecy, J.M.; Rohrer, G.; Sarropoulou, E.; Schmidt, C.J.; Silverstein, J.; Tellam, R.L.; Tixier-Boichard, M.; Tosser-klopp, G.; Tuggle, C.K.; Vilkki, J.; White, S.N.; Zhao, S.; Zhou, H.

    2015-01-01

    We describe the organization of a nascent international effort, the Functional Annotation of Animal Genomes (FAANG) project, whose aim is to produce comprehensive maps of functional elements in the genomes of domesticated animal species.

  4. MORE: Management of Requirements in NPP Modernisation Projects, final report

    International Nuclear Information System (INIS)

    Fredriksen, R.; Katta, V.; Raspotnig, C.; Valkonen, J.

    2008-09-01

    This report documents the work and related activities of the MORE (Management of Requirements in NPP Modernisation Projects) (NKS-R project number NKS-R-2005-47) project. This report also provides a summary of the project activities and deliverables, and discusses possible application areas. The project has aimed at the industrial utilisation of the results from the TACO: (Traceability and Communication of Requirements in Digital I and C Systems Development) (NKS-R project number NKS-R-2002-16, completed June, 2005) project, and practical application of improved approaches and methods for requirements engineering and change management. Finally, the report provides a brief description of the extended industrial network and disseminations of the results in Nordic and NKS related events such as seminars and workshops. (au)

  5. MORE: Management of Requirements in NPP Modernisation Projects, final report

    Energy Technology Data Exchange (ETDEWEB)

    Fredriksen, R.; Katta, V.; Raspotnig, C. (Inst. for energiteknikk (IFE) (Norway)); Valkonen, J. (Technical Research Centre of Finland (VTT) (Finland))

    2008-09-15

    This report documents the work and related activities of the MORE (Management of Requirements in NPP Modernisation Projects) (NKS-R project number NKS-R-2005-47) project. This report also provides a summary of the project activities and deliverables, and discusses possible application areas. The project has aimed at the industrial utilisation of the results from the TACO: (Traceability and Communication of Requirements in Digital I and C Systems Development) (NKS-R project number NKS-R-2002-16, completed June, 2005) project, and practical application of improved approaches and methods for requirements engineering and change management. Finally, the report provides a brief description of the extended industrial network and disseminations of the results in Nordic and NKS related events such as seminars and workshops. (author)

  6. FINAL REPORT FOR THE DIII-D RADIATIVE DIVERTOR PROJECT

    International Nuclear Information System (INIS)

    O'NEIL, RC; STAMBAUGH, RD

    2002-01-01

    OAK A271 FINAL REPORT FOR THE DIII-D RADIATIVE DIVERTOR PROJECT. The Radiative Divertor Project originated in 1993 when the DIII-D Five Year Plan for the period 1994--1998 was prepared. The Project Information Sheet described the objective of the project as ''to demonstrate dispersal of divertor power by a factor of then with sufficient diagnostics and modeling to extend the results to ITER and TPX''. Key divertor components identified were: (1) Carbon-carbon and graphite armor tiles; (2) The divertor structure providing a gas baffle and cooling; and (3) The divertor cryopumps to pump fuel and impurities

  7. The Qatar genome project: translation of whole-genome sequencing into clinical practice.

    Science.gov (United States)

    Zayed, Hatem

    2016-10-01

    Qatar Genome Project was launched in 2013 with the intent to sequence the genome of each Qatari citizen in an effort to protect Qataris from the high rate of indigenous genetic diseases by allowing the mapping of disease-causing variants/rare variants and establishing a Qatari reference genome. Indeed, this project is expected to have numerous global benefits because the elevated homogeneity of the Qatari population, that will make Qatar an excellent genetic laboratory that will generate a wealth of data that will allow us to make sense of the genotype-phenotype correlations of many diseases, especially the complex multifactorial diseases, and will pave the way for changing the traditional medical practice of looking first at the phenotype rather than the genotype. © 2016 John Wiley & Sons Ltd.

  8. nGASP - the nematode genome annotation assessment project

    Energy Technology Data Exchange (ETDEWEB)

    Coghlan, A; Fiedler, T J; McKay, S J; Flicek, P; Harris, T W; Blasiar, D; Allen, J; Stein, L D

    2008-12-19

    While the C. elegans genome is extensively annotated, relatively little information is available for other Caenorhabditis species. The nematode genome annotation assessment project (nGASP) was launched to objectively assess the accuracy of protein-coding gene prediction software in C. elegans, and to apply this knowledge to the annotation of the genomes of four additional Caenorhabditis species and other nematodes. Seventeen groups worldwide participated in nGASP, and submitted 47 prediction sets for 10 Mb of the C. elegans genome. Predictions were compared to reference gene sets consisting of confirmed or manually curated gene models from WormBase. The most accurate gene-finders were 'combiner' algorithms, which made use of transcript- and protein-alignments and multi-genome alignments, as well as gene predictions from other gene-finders. Gene-finders that used alignments of ESTs, mRNAs and proteins came in second place. There was a tie for third place between gene-finders that used multi-genome alignments and ab initio gene-finders. The median gene level sensitivity of combiners was 78% and their specificity was 42%, which is nearly the same accuracy as reported for combiners in the human genome. C. elegans genes with exons of unusual hexamer content, as well as those with many exons, short exons, long introns, a weak translation start signal, weak splice sites, or poorly conserved orthologs were the most challenging for gene-finders. While the C. elegans genome is extensively annotated, relatively little information is available for other Caenorhabditis species. The nematode genome annotation assessment project (nGASP) was launched to objectively assess the accuracy of protein-coding gene prediction software in C. elegans, and to apply this knowledge to the annotation of the genomes of four additional Caenorhabditis species and other nematodes. Seventeen groups worldwide participated in nGASP, and submitted 47 prediction sets for 10 Mb of the C

  9. The Human Genome Diversity (HGD) Project. Summary document

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1993-12-31

    In 1991 a group of human geneticists and molecular biologists proposed to the scientific community that a world wide survey be undertaken of variation in the human genome. To aid their considerations, the committee therefore decided to hold a small series of international workshops to explore the major scientific issues involved. The intention was to define a framework for the project which could provide a basis for much wider and more detailed discussion and planning--it was recognized that the successful implementation of the proposed project, which has come to be known as the Human Genome Diversity (HGD) Project, would not only involve scientists but also various national and international non-scientific groups all of which should contribute to the project`s development. The international HGD workshop held in Sardinia in September 1993 was the last in the initial series of planning workshops. As such it not only explored new ground but also pulled together into a more coherent form much of the formal and informal discussion that had taken place in the preceding two years. This report presents the deliberations of the Sardinia workshop within a consideration of the overall development of the HGD Project to date.

  10. The international Genome sample resource (IGSR): A worldwide collection of genome variation incorporating the 1000 Genomes Project data.

    Science.gov (United States)

    Clarke, Laura; Fairley, Susan; Zheng-Bradley, Xiangqun; Streeter, Ian; Perry, Emily; Lowy, Ernesto; Tassé, Anne-Marie; Flicek, Paul

    2017-01-04

    The International Genome Sample Resource (IGSR; http://www.internationalgenome.org) expands in data type and population diversity the resources from the 1000 Genomes Project. IGSR represents the largest open collection of human variation data and provides easy access to these resources. IGSR was established in 2015 to maintain and extend the 1000 Genomes Project data, which has been widely used as a reference set of human variation and by researchers developing analysis methods. IGSR has mapped all of the 1000 Genomes sequence to the newest human reference (GRCh38), and will release updated variant calls to ensure maximal usefulness of the existing data. IGSR is collecting new structural variation data on the 1000 Genomes samples from long read sequencing and other technologies, and will collect relevant functional data into a single comprehensive resource. IGSR is extending coverage with new populations sequenced by collaborating groups. Here, we present the new data and analysis that IGSR has made available. We have also introduced a new data portal that increases discoverability of our data-previously only browseable through our FTP site-by focusing on particular samples, populations or data sets of interest. © The Author(s) 2016. Published by Oxford University Press on behalf of Nucleic Acids Research.

  11. Final report: 'Rhodopseudomonas palustris' genome workshop to be held in Spring of 2001; FINAL

    International Nuclear Information System (INIS)

    Harwood, Caroline S.

    2002-01-01

    The 'Rhodopseudomonas palustris' genome workshop took place in Iowa City on April 6-8, 2001. The purpose of the meeting was to instruct members of the annotation working group in approaches to accomplishing the 'human' phase of the 'R. palustris' genome annotation. A partial draft of a paper describing the 'Rhodopseudomonas palustris' genome has been written and a full version of the paper should be ready for submission by the end of the summer 2002

  12. Tritium research laboratory cleanup and transition project final report

    International Nuclear Information System (INIS)

    Johnson, A.J.

    1997-02-01

    This Tritium Research Laboratory Cleanup and Transition Project Final Report provides a high-level summary of this project's multidimensional accomplishments. Throughout this report references are provided for in-depth information concerning the various topical areas. Project related records also offer solutions to many of the technical and or administrative challenges that such a cleanup effort requires. These documents and the experience obtained during this effort are valuable resources to the DOE, which has more than 1200 other process contaminated facilities awaiting cleanup and reapplication or demolition

  13. Iowa Hill Pumped Storage Project Investigations - Final Technical Report

    Energy Technology Data Exchange (ETDEWEB)

    Hanson, David [Sacramento Municipal Unitlity District, Sacramento, CA (United States)

    2016-07-01

    This Final Technical Report is a summary of the activities and outcome of the Department of Energy (DOE) Assistance Agreement DE-EE0005414 with the Sacramento Municipal Utility District (SMUD). The Assistance Agreement was created in 2012 to support investigations into the Iowa Hill Pumped-storage Project (Project), a new development that would add an additional 400 MW of capacity to SMUD’s existing 688MW Upper American River Hydroelectric Project (UARP) in the Sierra Nevada mountains east of Sacramento, California.

  14. Public trust and 'ethics review' as a commodity: the case of Genomics England Limited and the UK's 100,000 genomes project.

    Science.gov (United States)

    Samuel, Gabrielle Natalie; Farsides, Bobbie

    2018-06-01

    The UK Chief Medical Officer's 2016 Annual Report, Generation Genome, focused on a vision to fully integrate genomics into all aspects of the UK's National Health Service (NHS). This process of integration, which has now already begun, raises a wide range of social and ethical concerns, many of which were discussed in the final Chapter of the report. This paper explores how the UK's 100,000 Genomes Project (100 kGP)-the catalyst for Generation Genome, and for bringing genomics into the NHS-is negotiating these ethical concerns. The UK's 100 kGP, promoted and delivered by Genomics England Limited (GEL), is an innovative venture aiming to sequence 100,000 genomes from NHS patients who have a rare disease, cancer, or an infectious disease. GEL has emphasised the importance of ethical governance and decision-making. However, some sociological critique argues that biomedical/technological organisations presenting themselves as 'ethical' entities do not necessarily reflect a space within which moral thinking occurs. Rather, the 'ethical work' conducted (and displayed) by organisations is more strategic, relating to the politics of the organisation and the need to build public confidence. We set out to explore whether GEL's ethical framework was reflective of this critique, and what this tells us more broadly about how genomics is being integrated into the NHS in response to the ethical and social concerns raised in Generation Genome. We do this by drawing on a series of 20 interviews with individuals associated with or working at GEL.

  15. Admiralty Inlet Pilot Tidal Project Final Technical Report

    Energy Technology Data Exchange (ETDEWEB)

    Collar, Craig [Public Utility District No. 1 of Snohomish County, Everett, WA (United States)

    2015-09-14

    This document represents the final report for the Admiralty Inlet Pilot Tidal Project, located in Puget Sound, Washington, United States. The Project purpose was to license, permit, and install a grid-connected deep-water tidal turbine array (two turbines) to be used as a platform to gather operational and environmental data on tidal energy generation. The data could then be used to better inform the viability of commercial tidal energy generation from technical, economic, social, and environmental standpoints. This data would serve as a critical step towards the responsible advancement of commercial scale tidal energy in the United States and around the world. In late 2014, Project activities were discontinued due to escalating costs, and the DOE award was terminated in early 2015. Permitting, licensing, and engineering design activities were completed under this award. Final design, deployment, operation, and monitoring were not completed. This report discusses the results and accomplishments achieved under the subject award.

  16. The Genome of the Netherlands: design, and project goals

    Science.gov (United States)

    Boomsma, Dorret I; Wijmenga, Cisca; Slagboom, Eline P; Swertz, Morris A; Karssen, Lennart C; Abdellaoui, Abdel; Ye, Kai; Guryev, Victor; Vermaat, Martijn; van Dijk, Freerk; Francioli, Laurent C; Hottenga, Jouke Jan; Laros, Jeroen F J; Li, Qibin; Li, Yingrui; Cao, Hongzhi; Chen, Ruoyan; Du, Yuanping; Li, Ning; Cao, Sujie; van Setten, Jessica; Menelaou, Androniki; Pulit, Sara L; Hehir-Kwa, Jayne Y; Beekman, Marian; Elbers, Clara C; Byelas, Heorhiy; de Craen, Anton J M; Deelen, Patrick; Dijkstra, Martijn; den Dunnen, Johan T; de Knijff, Peter; Houwing-Duistermaat, Jeanine; Koval, Vyacheslav; Estrada, Karol; Hofman, Albert; Kanterakis, Alexandros; Enckevort, David van; Mai, Hailiang; Kattenberg, Mathijs; van Leeuwen, Elisabeth M; Neerincx, Pieter B T; Oostra, Ben; Rivadeneira, Fernanodo; Suchiman, Eka H D; Uitterlinden, Andre G; Willemsen, Gonneke; Wolffenbuttel, Bruce H; Wang, Jun; de Bakker, Paul I W; van Ommen, Gert-Jan; van Duijn, Cornelia M

    2014-01-01

    Within the Netherlands a national network of biobanks has been established (Biobanking and Biomolecular Research Infrastructure-Netherlands (BBMRI-NL)) as a national node of the European BBMRI. One of the aims of BBMRI-NL is to enrich biobanks with different types of molecular and phenotype data. Here, we describe the Genome of the Netherlands (GoNL), one of the projects within BBMRI-NL. GoNL is a whole-genome-sequencing project in a representative sample consisting of 250 trio-families from all provinces in the Netherlands, which aims to characterize DNA sequence variation in the Dutch population. The parent–offspring trios include adult individuals ranging in age from 19 to 87 years (mean=53 years; SD=16 years) from birth cohorts 1910–1994. Sequencing was done on blood-derived DNA from uncultured cells and accomplished coverage was 14–15x. The family-based design represents a unique resource to assess the frequency of regional variants, accurately reconstruct haplotypes by family-based phasing, characterize short indels and complex structural variants, and establish the rate of de novo mutational events. GoNL will also serve as a reference panel for imputation in the available genome-wide association studies in Dutch and other cohorts to refine association signals and uncover population-specific variants. GoNL will create a catalog of human genetic variation in this sample that is uniquely characterized with respect to micro-geographic location and a wide range of phenotypes. The resource will be made available to the research and medical community to guide the interpretation of sequencing projects. The present paper summarizes the global characteristics of the project. PMID:23714750

  17. Final Technical Report - Mechanisms and pathways controlling genomic instability

    Energy Technology Data Exchange (ETDEWEB)

    Dynan, William S. [Georgia Regents Univ., Augusta, GA (United States)

    2013-05-31

    This project used model organisms, the zebrafish and the Japanese medaka fish to investigate the effects of low-dose radiation exposure on the vertebrate embryo. Endpoints measured included apoptotic cell death, aging, and oxidative stress.

  18. MAKER2: an annotation pipeline and genome-database management tool for second-generation genome projects.

    Science.gov (United States)

    Holt, Carson; Yandell, Mark

    2011-12-22

    Second-generation sequencing technologies are precipitating major shifts with regards to what kinds of genomes are being sequenced and how they are annotated. While the first generation of genome projects focused on well-studied model organisms, many of today's projects involve exotic organisms whose genomes are largely terra incognita. This complicates their annotation, because unlike first-generation projects, there are no pre-existing 'gold-standard' gene-models with which to train gene-finders. Improvements in genome assembly and the wide availability of mRNA-seq data are also creating opportunities to update and re-annotate previously published genome annotations. Today's genome projects are thus in need of new genome annotation tools that can meet the challenges and opportunities presented by second-generation sequencing technologies. We present MAKER2, a genome annotation and data management tool designed for second-generation genome projects. MAKER2 is a multi-threaded, parallelized application that can process second-generation datasets of virtually any size. We show that MAKER2 can produce accurate annotations for novel genomes where training-data are limited, of low quality or even non-existent. MAKER2 also provides an easy means to use mRNA-seq data to improve annotation quality; and it can use these data to update legacy annotations, significantly improving their quality. We also show that MAKER2 can evaluate the quality of genome annotations, and identify and prioritize problematic annotations for manual review. MAKER2 is the first annotation engine specifically designed for second-generation genome projects. MAKER2 scales to datasets of any size, requires little in the way of training data, and can use mRNA-seq data to improve annotation quality. It can also update and manage legacy genome annotation datasets.

  19. MIT LMFBR blanket research project. Final summary report

    International Nuclear Information System (INIS)

    Driscoll, M.J.

    1983-08-01

    This is a final summary report on an experimental and analytical program for the investigation of LMFBR blanket characteristics carried out at MIT in the period 1969 to 1983. During this span of time, work was carried out on a wide range of subtasks, ranging from neutronic and photonic measurements in mockups of blankets using the Blanket Test Facility at the MIT Research Reactor, to analytic/numerical investigations of blanket design and economics. The main function of this report is to serve as a resource document which will permit ready reference to the more detailed topical reports and theses issued over the years on the various aspects of project activities. In addition, one aspect of work completed during the final year of the project, on doubly-heterogeneous blanket configurations, is documented for the record

  20. Final design review report for K basin dose reduction project

    International Nuclear Information System (INIS)

    Blackburn, L.D.

    1996-01-01

    The strategy for reducing radiation dose originating from radionuclides absorbed in the K East Basin concrete is to raise the pool water level to provide additional shielding. This report documents a final design review for cleaning/coating basin walls and modifying other basin components where appropriate. The conclusion of this review was that the documents developed constitute an acceptable design for the Dose Reduction Project

  1. The Personal Genome Project Canada: findings from whole genome sequences of the inaugural 56 participants.

    Science.gov (United States)

    Reuter, Miriam S; Walker, Susan; Thiruvahindrapuram, Bhooma; Whitney, Joe; Cohn, Iris; Sondheimer, Neal; Yuen, Ryan K C; Trost, Brett; Paton, Tara A; Pereira, Sergio L; Herbrick, Jo-Anne; Wintle, Richard F; Merico, Daniele; Howe, Jennifer; MacDonald, Jeffrey R; Lu, Chao; Nalpathamkalam, Thomas; Sung, Wilson W L; Wang, Zhuozhi; Patel, Rohan V; Pellecchia, Giovanna; Wei, John; Strug, Lisa J; Bell, Sherilyn; Kellam, Barbara; Mahtani, Melanie M; Bassett, Anne S; Bombard, Yvonne; Weksberg, Rosanna; Shuman, Cheryl; Cohn, Ronald D; Stavropoulos, Dimitri J; Bowdin, Sarah; Hildebrandt, Matthew R; Wei, Wei; Romm, Asli; Pasceri, Peter; Ellis, James; Ray, Peter; Meyn, M Stephen; Monfared, Nasim; Hosseini, S Mohsen; Joseph-George, Ann M; Keeley, Fred W; Cook, Ryan A; Fiume, Marc; Lee, Hin C; Marshall, Christian R; Davies, Jill; Hazell, Allison; Buchanan, Janet A; Szego, Michael J; Scherer, Stephen W

    2018-02-05

    The Personal Genome Project Canada is a comprehensive public data resource that integrates whole genome sequencing data and health information. We describe genomic variation identified in the initial recruitment cohort of 56 volunteers. Volunteers were screened for eligibility and provided informed consent for open data sharing. Using blood DNA, we performed whole genome sequencing and identified all possible classes of DNA variants. A genetic counsellor explained the implication of the results to each participant. Whole genome sequencing of the first 56 participants identified 207 662 805 sequence variants and 27 494 copy number variations. We analyzed a prioritized disease-associated data set ( n = 1606 variants) according to standardized guidelines, and interpreted 19 variants in 14 participants (25%) as having obvious health implications. Six of these variants (e.g., in BRCA1 or mosaic loss of an X chromosome) were pathogenic or likely pathogenic. Seven were risk factors for cancer, cardiovascular or neurobehavioural conditions. Four other variants - associated with cancer, cardiac or neurodegenerative phenotypes - remained of uncertain significance because of discrepancies among databases. We also identified a large structural chromosome aberration and a likely pathogenic mitochondrial variant. There were 172 recessive disease alleles (e.g., 5 individuals carried mutations for cystic fibrosis). Pharmacogenomics analyses revealed another 3.9 potentially relevant genotypes per individual. Our analyses identified a spectrum of genetic variants with potential health impact in 25% of participants. When also considering recessive alleles and variants with potential pharmacologic relevance, all 56 participants had medically relevant findings. Although access is mostly limited to research, whole genome sequencing can provide specific and novel information with the potential of major impact for health care. © 2018 Joule Inc. or its licensors.

  2. Advanced Air Transportation Technologies Project, Final Document Collection

    Science.gov (United States)

    Mogford, Richard H.; Wold, Sheryl (Editor)

    2008-01-01

    This CD ROM contains a compilation of the final documents of the Advanced Air Transportation Technologies (AAIT) project, which was an eight-year (1996 to 2004), $400M project managed by the Airspace Systems Program office, which was part of the Aeronautics Research Mission Directorate at NASA Headquarters. AAIT focused on developing advanced automation tools and air traffic management concepts that would help improve the efficiency of the National Airspace System, while maintaining or enhancing safety. The documents contained in the CD are final reports on AAIT tasks that serve to document the project's accomplishments over its eight-year term. Documents include information on: Advanced Air Transportation Technologies, Autonomous Operations Planner, Collaborative Arrival Planner, Distributed Air/Ground Traffic Management Concept Elements 5, 6, & 11, Direct-To, Direct-To Technology Transfer, Expedite Departure Path, En Route Data Exchange, Final Approach Spacing Tool - (Active and Passive), Multi-Center Traffic Management Advisor, Multi Center Traffic Management Advisor Technology Transfer, Surface Movement Advisor, Surface Management System, Surface Management System Technology Transfer and Traffic Flow Management Research & Development.

  3. Documenting genomics: Applying archival theory to preserving the records of the Human Genome Project.

    Science.gov (United States)

    Shaw, Jennifer

    2016-02-01

    The Human Genome Archive Project (HGAP) aimed to preserve the documentary heritage of the UK's contribution to the Human Genome Project (HGP) by using archival theory to develop a suitable methodology for capturing the results of modern, collaborative science. After assessing past projects and different archival theories, the HGAP used an approach based on the theory of documentation strategy to try to capture the records of a scientific project that had an influence beyond the purely scientific sphere. The HGAP was an archival survey that ran for two years. It led to ninety scientists being contacted and has, so far, led to six collections being deposited in the Wellcome Library, with additional collections being deposited in other UK repositories. In applying documentation strategy the HGAP was attempting to move away from traditional archival approaches to science, which have generally focused on retired Nobel Prize winners. It has been partially successful in this aim, having managed to secure collections from people who are not 'big names', but who made an important contribution to the HGP. However, the attempt to redress the gender imbalance in scientific collections and to improve record-keeping in scientific organisations has continued to be difficult to achieve. Copyright © 2015 The Author. Published by Elsevier Ltd.. All rights reserved.

  4. Wabash River Coal Gasification Repowering Project: A DOE Assessment; FINAL

    International Nuclear Information System (INIS)

    National Energy Technology Laboratory

    2002-01-01

    The goal of the U.S. Department of Energy (DOE) Clean Coal Technology Program (CCT) is to furnish the energy marketplace with a number of advanced, more efficient, and environmentally responsible coal utilization technologies through demonstration projects. These projects seek to establish the commercial feasibility of the most promising advanced coal technologies that have developed beyond the proof-of-concept stage. This document serves as a DOE post-project assessment (PPA) of a project selected in CCT Round IV, the Wabash River Coal Gasification Repowering (WRCGR) Project, as described in a Report to Congress (U.S. Department of Energy 1992). Repowering consists of replacing an existing coal-fired boiler with one or more clean coal technologies to achieve significantly improved environmental performance. The desire to demonstrate utility repowering with a two-stage, pressurized, oxygen-blown, entrained-flow, integrated gasification combined-cycle (IGCC) system prompted Destec Energy, Inc., and PSI Energy, Inc., to form a joint venture and submit a proposal for this project. In July 1992, the Wabash River Coal Gasification Repowering Project Joint Venture (WRCGRPJV, the Participant) entered into a cooperative agreement with DOE to conduct this project. The project was sited at PSI Energy's Wabash River Generating Station, located in West Terre Haute, Indiana. The purpose of this CCT project was to demonstrate IGCC repowering using a Destec gasifier and to assess long-term reliability, availability, and maintainability of the system at a fully commercial scale. DOE provided 50 percent of the total project funding (for capital and operating costs during the demonstration period) of$438 million. Construction for the demonstration project was started in July 1993. Pre-operational tests were initiated in August 1995, and construction was completed in November 1995. Commercial operation began in November 1995, and the demonstration period was completed in December

  5. District heating demonstration project. Swiecie, Poland. Final report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-06-01

    In January 1997 the district heating company in Swiecie, Poland, was donated DKK 1.3 Mio. as a part of the environmental related energy sector programme by the Danish government for a demonstration project. The Danish consultancy company Carl Bro a/s was appointed to conduct the work. The project was finished in January 1999. The present final report outlines the activities of the demonstration project. The activities of the project were several. Carl Bro a/s elaborated tender documents and procured 79 heat meters for all the substrations in the city in order to prepare for the new energy law and a changed tariff system which was introduced in January 1999. Carl Bro a/s further supported ZEC Swiecie in the development of their new tariff system through information from Danish district heating companies. The demonstration project was designed in the first phase of the project. During the design period one engineer from Swiecie participated in a study tour to Denmark to learn about technical solutions to present problems in Poland. The training course focused on preparation of hot tap water. The site for the demonstation project was in the centre of Swiecie in a housing society located in Wojska Polskiego. The blocks 75 and 75A were selected for modernisation of the substations, and block no. 73 was appointed as a reference block in which only a heat meter was installed. Further, block 75A was equipped with thermostatic valves at all the radiators in the flats. The registered savings during the monitoring period were between 7% and 14%, and an increased comfort in the flats was observed. The housing society`s board of directors were so pleased with the project that by their initiative block no. 77 was refurbished in the same way as the blocks covered by the demonstration project. However, the activities were extended with individual heat meters and the introduction of a new tariff system for the block. The energy savings from this project were substantial, and today

  6. Relationship between Deleterious Variation, Genomic Autozygosity, and Disease Risk: Insights from The 1000 Genomes Project.

    Science.gov (United States)

    Pemberton, Trevor J; Szpiech, Zachary A

    2018-04-05

    Genomic regions of autozygosity (ROAs) represent segments of individual genomes that are homozygous for haplotypes inherited identical-by-descent (IBD) from a common ancestor. ROAs are nonuniformly distributed across the genome, and increased ROA levels are a reported risk factor for numerous complex diseases. Previously, we hypothesized that long ROAs are enriched for deleterious homozygotes as a result of young haplotypes with recent deleterious mutations-relatively untouched by purifying selection-being paired IBD as a consequence of recent parental relatedness, a pattern supported by ROA and whole-exome sequence data on 27 individuals. Here, we significantly bolster support for our hypothesis and expand upon our original analyses using ROA and whole-genome sequence data on 2,436 individuals from The 1000 Genomes Project. Considering CADD deleteriousness scores, we reaffirm our previous observation that long ROAs are enriched for damaging homozygotes worldwide. We show that strongly damaging homozygotes experience greater enrichment than weaker damaging homozygotes, while overall enrichment varies appreciably among populations. Mendelian disease genes and those encoding FDA-approved drug targets have significantly increased rates of gain in damaging homozygotes with increasing ROA coverage relative to all other genes. In genes implicated in eight complex phenotypes for which ROA levels have been identified as a risk factor, rates of gain in damaging homozygotes vary across phenotypes and populations but frequently differ significantly from non-disease genes. These findings highlight the potential confounding effects of population background in the assessment of associations between ROA levels and complex disease risk, which might underlie reported inconsistencies in ROA-phenotype associations. Copyright © 2018 American Society of Human Genetics. Published by Elsevier Inc. All rights reserved.

  7. Gene disruptions using P transposable elements: an integral component of the Drosophila genome project.

    OpenAIRE

    Spradling, A C; Stern, D M; Kiss, I; Roote, J; Laverty, T; Rubin, G M

    1995-01-01

    Biologists require genetic as well as molecular tools to decipher genomic information and ultimately to understand gene function. The Berkeley Drosophila Genome Project is addressing these needs with a massive gene disruption project that uses individual, genetically engineered P transposable elements to target open reading frames throughout the Drosophila genome. DNA flanking the insertions is sequenced, thereby placing an extensive series of genetic markers on the physical genomic map and a...

  8. Prototypical consolidation demonstration project - Final fuel recommendation report

    International Nuclear Information System (INIS)

    Piscitella, R.R.; Paskey, W.R.

    1987-01-01

    The Prototypical Consolidation Demonstration (PCD) Project will, in its final phase, conduct a demonstration of the equipment's ability to consolidate actual spent commercial fuel. Since budget and schedule limitations do not allow this demonstration to include all types of fuel assemblies, a selection process was utilized to identify the fuel types that would represent predominate fuel inventories and that would demonstrate the equipment's abilities. The Pressurized Water Reactor (PWR) fuel assemblies that were suggested for use in the PCD Project Hot Demonstration were Babcock and Wilcox (B and W) 15 x 15's, and Westinghouse (WE) 15 x 15's. The Boiling Water Reactor (BWR) fuel suggested was the General Electric (GE) 8 x 8

  9. Programmable SAW development :Sandia/NASA project final report.

    Energy Technology Data Exchange (ETDEWEB)

    Brocato, Robert Wesley

    2004-10-01

    This report describes a project to develop both fixed and programmable surface acoustic wave (SAW) correlators for use in a low power space communication network. This work was funded by NASA at Sandia National Laboratories for fiscal years 2004, 2003, and the final part of 2002. The role of Sandia was to develop the SAW correlator component, although additional work pertaining to use of the component in a system and system optimization was also done at Sandia. The potential of SAW correlator-based communication systems, the design and fabrication of SAW correlators, and general system utilization of those correlators are discussed here.

  10. Final Technical Report, Wind Generator Project (Ann Arbor)

    Energy Technology Data Exchange (ETDEWEB)

    Geisler, Nathan [City of Ann Arbor, MI (United States)

    2017-03-20

    A Final Technical Report (57 pages) describing educational exhibits and devices focused on wind energy, and related outreach activities and programs. Project partnership includes the City of Ann Arbor, MI and the Ann Arbor Hands-on Museum, along with additional sub-recipients, and U.S. Department of Energy/Office of Energy Efficiency and Renewable Energy (EERE). Report relays key milestones and sub-tasks as well as numerous graphics and images of five (5) transportable wind energy demonstration devices and five (5) wind energy exhibits designed and constructed between 2014 and 2016 for transport and use by the Ann Arbor Hands-on Museum.

  11. District Heating Demonstration project. Bydgoszcz, Poland, Final report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-06-01

    The project was finished in January 1999. The present final report outlines the activities of the pilot project. The activities of the project were: Development of a general model or a design strategy for the modernisation of group substations; Training of selected staff in updated design and latest technologies; Comparing experiences from the reconstructed heat exchanger station with alternative solutions; Investigation of potential sources of financing for the modernisation of the district heating system based on a revised feasibility study. The development of a general model for the future design of the heat exchanger station and the substations resulted in a design guideline which was used for the design of the heat exchanger station. KPEC selected the heat exchanger station CC02, located in area B1, as the object for the heat exchanger reconstruction. The station supplies 42 substations in 20 dwelling houses with a total heat demand of 11 MW. The design of the reconstruction began in the autumn of 1996. The equipment was procured during the spring of 1997 and the bulk of the installation work was finished by October 1997. The appointed design engineer participated in two study tours to Denmark. During the implementation the project was enlarged with an addendum. The addendum consisted of a modernisation of twelve building substations. The monitoring programme was enlarged accordingly and the efficiency of the two solutions were compared and evaluated through the monitoring programme. Even though some of the data are rather limited, the monitoring programme reveals a tendency towards the substation modernisation being twice as efficient as the heat exchanger modernisation. The reconstruction of the heat exchanger station has indicated a heat saving potential of 10% whereas the substation project has indicated a heat saving potential of 20%. The project further shows a huge potential for power savings in the main pumps due to the automatic control. (EHS)

  12. Final Technical Report - Kotzebue Wind Power Project - Volume II

    Energy Technology Data Exchange (ETDEWEB)

    Rana Zucchi, Global Energy Concepts, LLC; Brad Reeve, Kotzebue Electric Association; DOE Project Officer - Doug Hooker

    2007-10-31

    The Kotzebue Wind Power Project is a joint undertaking of the U.S. Department of Energy (DOE); Kotzebue Electric Association (KEA); and the Alaska Energy Authority (AEA). The goal of the project is to develop, construct, and operate a wind power plant interconnected to a small isolated utility grid in an arctic climate in Northwest Alaska. The primary objective of KEA’s wind energy program is to bring more affordable electricity and jobs to remote Alaskan communities. DOE funding has allowed KEA to develop a multi-faceted approach to meet these objectives that includes wind project planning and development, technology transfer, and community outreach. The first wind turbines were installed in the summer of 1997 and the newest turbines were installed in the spring of 2007. The total installed capacity of the KEA wind power project is 1.16 MW with a total of 17 turbines rated between 65 kW and 100 kW. The operation of the wind power plant has resulted in a wind penetration on the utility system in excess of 35% during periods of low loads. This document and referenced attachments are presented as the final technical report for the U.S. Department of Energy (DOE) grant agreement DE-FG36-97GO10199. Interim deliverables previously submitted are also referenced within this document and where reasonable to do so, specific sections are incorporated in the report or attached as appendices.

  13. Hellsgate Winter Range : Wildlife Mitigation Project. Final Environmental Assessment.

    Energy Technology Data Exchange (ETDEWEB)

    United States. Bonneville Power Administration.

    1995-03-01

    Bonneville Power Administration (BPA) proposes to fund the Hellsgate Winter Range Wildlife Mitigation Project (Project) in a cooperative effort with the Colville Confederated Tribes and the Bureau of Indian Affairs (BIA). The proposed action would allow the sponsors to secure property and conduct wildlife management activities within the boundaries of the Colville Indian Reservation. This Final Environmental Assessment (EA) examines the potential environmental effects of acquiring and managing property for wildlife and wildlife habitat within a large project area. This area consists of several separated land parcels, of which 2,000 hectares (4,943 acres) have been purchased by BPA and an additional 4,640 hectares (11,466 acres) have been identified by the Colville Confederated Tribes for inclusion in the Project. Four proposed activities (habitat protection, habitat enhancement, operation and maintenance, and monitoring and evaluation) are analyzed. The proposed action is intended to meet the need for mitigation of wildlife and wildlife habitat that was adversely affected by the construction of Grand Coulee and Chief Joseph Dams and their reservoirs.

  14. Hellsgate Winter Range: Wildlife mitigation project. Final environmental assessment

    International Nuclear Information System (INIS)

    1995-03-01

    Bonneville Power Administration (BPA) proposes to fund the Hellsgate Winter Range Wildlife Mitigation Project (Project) in a cooperative effort with the Colville Confederated Tribes and the Bureau of Indian Affairs (BIA). The proposed action would allow the sponsors to secure property and conduct wildlife management activities within the boundaries of the Colville Indian Reservation. This Final Environmental Assessment (EA) examines the potential environmental effects of acquiring and managing property for wildlife and wildlife habitat within a large project area. This area consists of several separated land parcels, of which 2,000 hectares (4,943 acres) have been purchased by BPA and an additional 4,640 hectares (11,466 acres) have been identified by the Colville Confederated Tribes for inclusion in the Project. Four proposed activities (habitat protection, habitat enhancement, operation and maintenance, and monitoring and evaluation) are analyzed. The proposed action is intended to meet the need for mitigation of wildlife and wildlife habitat that was adversely affected by the construction of Grand Coulee and Chief Joseph Dams and their reservoirs

  15. Ferrocyanide safety project ferrocyanide aging studies. Final report

    International Nuclear Information System (INIS)

    Lilga, M.A.; Hallen, R.T.; Alderson, E.V.

    1996-06-01

    This final report gives the results of the work conducted by Pacific Northwest National Laboratory (PNNL) from FY 1992 to FY 1996 on the Ferrocyanide Aging Studies, part of the Ferrocyanide Safety Project. The Ferrocyanide Safety Project was initiated as a result of concern raised about the safe storage of ferrocyanide waste intermixed with oxidants, such as nitrate and nitrite salts, in Hanford Site single-shell tanks (SSTs). In the laboratory, such mixtures can be made to undergo uncontrolled or explosive reactions by heating dry reagents to over 200 degrees C. In 1987, an Environmental Impact Statement (EIS), published by the U.S. Department of Energy (DOE), Final Environmental Impact Statement, Disposal of Hanford Defense High-Level Transuranic and Tank Waste, Hanford Site, Richland, Washington, included an environmental impact analysis of potential explosions involving ferrocyanide-nitrate mixtures. The EIS postulated that an explosion could occur during mechanical retrieval of saltcake or sludge from a ferrocyanide waste tank, and concluded that this worst-case accident could create enough energy to release radioactive material to the atmosphere through ventilation openings, exposing persons offsite to a short-term radiation dose of approximately 200 mrem. Later, in a separate study (1990), the General Accounting Office postulated a worst-case accident of one to two orders of magnitude greater than that postulated in the DOE EIS. The uncertainties regarding the safety envelope of the Hanford Site ferrocyanide waste tanks led to the declaration of the Ferrocyanide Unreviewed Safety Question (USQ) in October 1990

  16. The GenABEL Project for statistical genomics.

    Science.gov (United States)

    Karssen, Lennart C; van Duijn, Cornelia M; Aulchenko, Yurii S

    2016-01-01

    Development of free/libre open source software is usually done by a community of people with an interest in the tool. For scientific software, however, this is less often the case. Most scientific software is written by only a few authors, often a student working on a thesis. Once the paper describing the tool has been published, the tool is no longer developed further and is left to its own device. Here we describe the broad, multidisciplinary community we formed around a set of tools for statistical genomics. The GenABEL project for statistical omics actively promotes open interdisciplinary development of statistical methodology and its implementation in efficient and user-friendly software under an open source licence. The software tools developed withing the project collectively make up the GenABEL suite, which currently consists of eleven tools. The open framework of the project actively encourages involvement of the community in all stages, from formulation of methodological ideas to application of software to specific data sets. A web forum is used to channel user questions and discussions, further promoting the use of the GenABEL suite. Developer discussions take place on a dedicated mailing list, and development is further supported by robust development practices including use of public version control, code review and continuous integration. Use of this open science model attracts contributions from users and developers outside the "core team", facilitating agile statistical omics methodology development and fast dissemination.

  17. The human genome project and the Catholic Church (1)

    Science.gov (United States)

    Moraczewski, Albert S

    1991-12-01

    The Cathlic Church has not made any formal statements about the Human Genome Project as such. But the present Pope, John Paul II, has commented, albeit very briefly, on various aspects of genetic manipulation. Genetic interventions which are therapeutic (e.g. gene therapy), namely, directed to the correction or amelioration of a disorder are acceptable, in principle, provided they promote the personal well being of the individual being so treated. Genetic interventions which are not therapeutic for the specific individual involved but are experimental and directed primarily to improving humans as biological entities are of dubious moral probity, but are not necessarily to be totally rejected out of hand. To be morally acceptable such genetic intervention should meet certain conditions which include due respect for the given psychological nature of each individual human being. In addition, no harm should be inflicted on the process of human generation, and its fundamental design should not be altered. Any genetic manipulation which results in, or tends to, the creation of groups with different qualities such that there would result a fresh marginalization of these people must be avoided. It has been also suggested by a few that because the Son of God took on a human nature in Jesus Christ, one may not so alter the human genome that a new distinct species would be created....

  18. The UK Human Genome Mapping Project online computing service.

    Science.gov (United States)

    Rysavy, F R; Bishop, M J; Gibbs, G P; Williams, G W

    1992-04-01

    This paper presents an overview of computing and networking facilities developed by the Medical Research Council to provide online computing support to the Human Genome Mapping Project (HGMP) in the UK. The facility is connected to a number of other computing facilities in various centres of genetics and molecular biology research excellence, either directly via high-speed links or through national and international wide-area networks. The paper describes the design and implementation of the current system, a 'client/server' network of Sun, IBM, DEC and Apple servers, gateways and workstations. A short outline of online computing services currently delivered by this system to the UK human genetics research community is also provided. More information about the services and their availability could be obtained by a direct approach to the UK HGMP-RC.

  19. The impact of the human genome project on risk assessment

    International Nuclear Information System (INIS)

    Katarzyna Doerffer; Paul Unrau.

    1996-01-01

    The radiation protection approach to risk assessment assumes that cancer induction following radiation exposure is purely random. Present risk assessment methods derive risk from cancer incidence frequencies in exposed populations and associate disease outcomes totally with the level of exposure to ionizing red aeon. Exposure defines a risk factor that affects the probability of the disease outcome. But cancer risk can be affected by other risk factors such as underlying genetic factors (predisposition) of the exposed organism. These genetic risk factors are now becoming available for incorporation into ionizing radiation risk assessment Progress in the Human Genome Project (HOP) will lead to direct assays to measure the effects of genetic risk determinants in disease outcomes. When all genetic risk determinants are known and incorporated into risk assessment it will be possible to reevaluate the role of ionizing radiation in the causation of cancer. (author)

  20. Blue Creek Winter Range: Wildlife Mitigation Project. Final environmental assessment

    International Nuclear Information System (INIS)

    1994-11-01

    Bonneville Power Administration (BPA) proposes to fund that portion of the Washington Wildlife Agreement pertaining to the Blue Creek Winter Range Wildlife Mitigation Project (Project) in a cooperative effort with the Spokane Tribe, Upper Columbia United Tribes, and the Bureau of Indian Affairs (BIA). If fully implemented, the proposed action would allow the sponsors to protect and enhance 2,631 habitat units of big game winter range and riparian shrub habitat on 2,185 hectares (5,400 acres) of Spokane Tribal trust lands, and to conduct long term wildlife management activities within the Spokane Indian Reservation project area. This Final Environmental Assessment (EA) examines the potential environmental effects of securing land and conducting wildlife habitat enhancement and long term management activities within the boundaries of the Spokane Indian Reservation. Four proposed activities (habitat protection, habitat enhancement, operation and maintenance, and monitoring and evaluation) are analyzed. The proposed action is intended to meet the need for mitigation of wildlife and wildlife habitat adversely affected by the construction of Grand Coulee Dam and its reservoir

  1. Northeast Oregon Hatchery Project, Conceptual Design Report, Final Report.

    Energy Technology Data Exchange (ETDEWEB)

    Watson, Montgomery (Montgomery Watson, Bellevue, WA)

    1995-03-01

    This report presents the results of site analysis for the Bonneville Power Administration Northeast Oregon Hatchery Project. The purpose of this project is to provide engineering services for the siting and conceptual design of hatchery facilities for the Bonneville Power Administration. The hatchery project consists of artificial production facilities for salmon and steelhead to enhance production in three adjacent tributaries to the Columbia River in northeast Oregon: the Grande Ronde, Walla Walla, and Imnaha River drainage basins. Facilities identified in the master plan include adult capture and holding facilities; spawning incubation, and early rearing facilities; full-term rearing facilities; and direct release or acclimation facilities. The evaluation includes consideration of a main production facility for one or more of the basins or several smaller satellite production facilities to be located within major subbasins. The historic and current distribution of spring and fall chinook salmon and steelhead was summarized for the Columbia River tributaries. Current and future production and release objectives were reviewed. Among the three tributaries, forty seven sites were evaluated and compared to facility requirements for water and space. Site screening was conducted to identify the sites with the most potential for facility development. Alternative sites were selected for conceptual design of each facility type. A proposed program for adult holding facilities, final rearing/acclimation, and direct release facilities was developed.

  2. Northeast Oregon Hatchery Project conceptual design report. Final report

    International Nuclear Information System (INIS)

    1995-03-01

    This report presents the results of site analysis for the Bonneville Power Administration Northeast Oregon Hatchery Project. The purpose of this project is to provide engineering services for the siting and conceptual design of hatchery facilities for the Bonneville Power Administration. The hatchery project consists of artificial production facilities for salmon and steelhead to enhance production in three adjacent tributaries to the Columbia River in northeast Oregon: the Grande Ronde, Walla Walla, and Imnaha River drainage basins. Facilities identified in the master plan include adult capture and holding facilities; spawning incubation, and early rearing facilities; full-term rearing facilities; and direct release or acclimation facilities. The evaluation includes consideration of a main production facility for one or more of the basins or several smaller satellite production facilities to be located within major subbasins. The historic and current distribution of spring and fall chinook salmon and steelhead was summarized for the Columbia River tributaries. Current and future production and release objectives were reviewed. Among the three tributaries, forty seven sites were evaluated and compared to facility requirements for water and space. Site screening was conducted to identify the sites with the most potential for facility development. Alternative sites were selected for conceptual design of each facility type. A proposed program for adult holding facilities, final rearing/acclimation, and direct release facilities was developed

  3. Final Report Sustained Spheromak Physics Project FY 1997 - FY 1999

    International Nuclear Information System (INIS)

    Hooper, E.B.; Hill, D.N.

    2000-01-01

    This is the final report on the LDRD SI-funded Sustained Spheromak Physics Project for the years FY1997-FY1999, during which the SSPX spheromak was designed, built, and commissioned for operation at LLNL. The specific LDRD project covered in this report concerns the development, installation, and operation of specialized hardware and diagnostics for use on the SSPX facility in order to study energy confinement in a sustained spheromak plasma configuration. The USDOE Office of Fusion Energy Science funded the construction and routine operation of the SSPX facility. The main distinctive feature of the spheromak is that currents in the plasma itself produce the confining toroidal magnetic field, rather than external coils, which necessarily thread the vacuum vessel. There main objective of the Sustained Spheromak Physics Project was to test whether sufficient energy confinement could be maintained in a spheromak plasma sustained by DC helicity injection. Achieving central electron temperatures of several hundred eV would indicate this. In addition, we set out to determine how the energy confinement scales with T c and to relate the confinement time to the level of internal magnetic turbulence. Energy confinement and its scaling are the central technical issues for the spheromak as a fusion reactor concept. Pending the outcome of energy confinement studies now under way, the spheromak could be the basis for an attractive fusion reactor because of its compact size, simply-connected magnetic geometry, and potential for steady-state current drive

  4. The Epilepsy Phenome/Genome Project (EPGP) informatics platform.

    Science.gov (United States)

    Nesbitt, Gerry; McKenna, Kevin; Mays, Vickie; Carpenter, Alan; Miller, Kevin; Williams, Michael

    2013-04-01

    The Epilepsy Phenome/Genome Project (EPGP) is a large-scale, multi-institutional, collaborative network of 27 epilepsy centers throughout the U.S., Australia, and Argentina, with the objective of collecting detailed phenotypic and genetic data on a large number of epilepsy participants. The goals of EPGP are (1) to perform detailed phenotyping on 3750 participants with specific forms of non-acquired epilepsy and 1500 parents without epilepsy, (2) to obtain DNA samples on these individuals, and (3) to ultimately genotype the samples in order to discover novel genes that cause epilepsy. To carry out the project, a reliable and robust informatics platform was needed for standardized electronic data collection and storage, data quality review, and phenotypic analysis involving cases from multiple sites. EPGP developed its own suite of web-based informatics applications for participant tracking, electronic data collection (using electronic case report forms/surveys), data management, phenotypic data review and validation, specimen tracking, electroencephalograph and neuroimaging storage, and issue tracking. We implemented procedures to train and support end-users at each clinical site. Thus far, 3780 study participants have been enrolled and 20,957 web-based study activities have been completed using this informatics platform. Over 95% of respondents to an end-user satisfaction survey felt that the informatics platform was successful almost always or most of the time. The EPGP informatics platform has successfully and effectively allowed study management and efficient and reliable collection of phenotypic data. Our novel informatics platform met the requirements of a large, multicenter research project. The platform has had a high level of end-user acceptance by principal investigators and study coordinators, and can serve as a model for new tools to support future large scale, collaborative research projects collecting extensive phenotypic data. Copyright © 2012

  5. Ethical considerations of research policy for personal genome analysis: the approach of the Genome Science Project in Japan.

    Science.gov (United States)

    Minari, Jusaku; Shirai, Tetsuya; Kato, Kazuto

    2014-12-01

    As evidenced by high-throughput sequencers, genomic technologies have recently undergone radical advances. These technologies enable comprehensive sequencing of personal genomes considerably more efficiently and less expensively than heretofore. These developments present a challenge to the conventional framework of biomedical ethics; under these changing circumstances, each research project has to develop a pragmatic research policy. Based on the experience with a new large-scale project-the Genome Science Project-this article presents a novel approach to conducting a specific policy for personal genome research in the Japanese context. In creating an original informed-consent form template for the project, we present a two-tiered process: making the draft of the template following an analysis of national and international policies; refining the draft template in conjunction with genome project researchers for practical application. Through practical use of the template, we have gained valuable experience in addressing challenges in the ethical review process, such as the importance of sharing details of the latest developments in genomics with members of research ethics committees. We discuss certain limitations of the conventional concept of informed consent and its governance system and suggest the potential of an alternative process using information technology.

  6. ISS-NIH Collaborative Programme: final report of the projects

    International Nuclear Information System (INIS)

    2009-01-01

    In July 2003, the National Institutes of Health (NIH) of the United States of America and the Istituto Superiore di Sanita (ISS) of Italy signed an agreement aimed at strengthening the ongoing research cooperation between USA and Italy. Over the years, the programme was able to create new partnerships and to foster the establishment of innovative synergies, the exchange of young researcher, and the merging of the best available skills, talents and know-how in different fields of biomedical sciences. This book contains the final report of the projects of the scientific cooperation between the two Countries. The report consists of two parts (in Italian and English) divided into four sections: Cancer, Neuroscience, Cardiovascular diseases, Infectious diseases [it

  7. The lawful uses of knowledge from the Human Genome Project

    Energy Technology Data Exchange (ETDEWEB)

    Grad, F.P.

    1994-04-15

    Part I of this study deals with the right to know or not to know personal genetic information, and examines available legal protections of the right of privacy and the adverse effect of the disclosure of genetic information both on employment and insurance interests and on self esteem and protection of personal integrity. The study examines the rationale for the legal protection of privacy as the protection of a public interest. It examines the very limited protections currently available for privacy interests, including genetic privacy interests, and concludes that there is a need for broader, more far-reaching legal protections. The second part of the study is based on the assumption that as major a project as the Human Genome Project, spending billions of dollars on science which is health related, will indeed be applied for preventive and therapeutic public health purposes, as it has been in the past. It also addresses the recurring fear that public health initiatives in the genetic area must evolve a new eugenic agenda, that we must not repeat the miserable discriminatory experiences of the past.

  8. Manitoba Motor Dealers Association pilot project : final report

    International Nuclear Information System (INIS)

    2006-08-01

    This report described a 3-month pilot project conducted by EnerGuide for Vehicles in collaboration with the Manitoba Motor Dealers Association (MMDA) to increase dealership and consumer awareness of vehicle impacts on climate change. The project also aimed to engage MMDA's members in helping to promote and distribute information on fuel efficient vehicles and fuel efficient driving habits. Program tools in both the dealership showroom as well as service areas were used. Objectives of the project also included gaining public opinion research (POR) information regarding the impact of program tools; gaining feedback from new car dealers regarding the success of the project; gauging customer perceptions of the importance of fuel efficiency when selecting a new vehicle; determining whether or not drivers verify tire pressure on their vehicles; determining whether or not drivers incorporate energy efficient driving habits; and gauging customer perceptions regarding the importance of incorporating behaviours to improve fuel efficiency. The study used a mixed methodology of online and telephone surveys. A total of 41 dealerships participated in the project. The final sample of surveys consisted of 1926 customer records. The total overall number of completed interviews was 463. Results indicated that most dealers believed the campaign was a success, and that staff and customers learned about energy efficiency as a result of the campaign. Seventy-five per cent of dealers agreed that they would participate in future energy efficiency programs. Campaign materials and customer incentives were widely viewed as successful in raising awareness. Seven in 10 dealership customers recalled at least 1 of the promotional endeavours, and a large majority of customers indicated the information they saw at the dealership encouraged them to consider fuel efficiency when buying or maintaining a vehicle in the future. The majority of new customers considered fuel consumption to be the second

  9. Pilot project Uljabuouda. Final report; Pilotprojekt Uljabuouda. Slutrapport

    Energy Technology Data Exchange (ETDEWEB)

    2011-07-01

    During the period of 2007-2010 Skellefteaa Kraft AB erected a wind farm comprising 10 3 MW wind turbines on the mountain Uljabuouda in the municipality of Arjeplog. The turbines are of the type WWD-3 with a hub height of 80 meters and a rotor diameter of 90 meters. The Uljabuouda wind farm is one of the first erected above the treeline in the Swedish mountains. The wind turbines are adapted to cold climate equipped with an ice prevention system for the blades. The process of obtaining the necessary permits for the erection of the wind farm was lengthy and lasted during the period of 2000 to 2008. Also the procurement process took longer than expected. During the period of 2006-2008 when the procurement was performed it was difficult to find a supplier who could offer wind turbines equipped with a deicing system. In December 2006 the Uljabuouda project was granted a subsidy from the Swedish Energy Agency, the maximum of 35 million Swedish crowns. The final investment costs of the project will be higher than previously estimated. The main reason for this was the prevailing market conditions during the procurement period. The Uljabuouda wind farm is in full operation since the winter of 2010/2011 and so far our experiences are that the ice prevention system is working well even at harsh icing conditions

  10. Umatilla Satellite and Release Sites Project : Final Siting Report.

    Energy Technology Data Exchange (ETDEWEB)

    Montgomery, James M.

    1992-04-01

    This report presents the results of site analysis for the Umatilla Satellite and Release Sites Project. The purpose of this project is to provide engineering services for the siting and conceptual design of satellite and release facilities for the Umatilla Basin hatchery program. The Umatilla Basin hatchery program consists of artificial production facilities for salmon and steelhead to enhance production in the Umatilla River as defined in the Umatilla master plan approved in 1989 by the Northwest Power Planning Council. Facilities identified in the master plan include adult salmon broodstock holding and spawning facilities, facilities for recovery, acclimation, and/or extended rearing of salmon juveniles, and development of river sites for release of hatchery salmon and steelhead. The historic and current distribution of fall chinook, summer chinook, and coho salmon and steelhead trout was summarized for the Umatilla River basin. Current and future production and release objectives were reviewed. Twenty seven sites were evaluated for the potential and development of facilities. Engineering and environmental attributes of the sites were evaluated and compared to facility requirements for water and space. Site screening was conducted to identify the sites with the most potential for facility development. Alternative sites were selected for conceptual design of each facility type. A proposed program for adult holding facilities, final rearing/acclimation, and direct release facilities was developed.

  11. Final Report for NIREC Renewable Energy Research & Development Project

    Energy Technology Data Exchange (ETDEWEB)

    Borland, Walt [Nevada Institute for Renewable Energy Commercialization (NIREC), Las Vegas, NV (United States)

    2017-05-02

    This report is a compilation of progress reports and presentations submitted by NIREC to the DOE’s Solar Energy Technologies Office for award number DE-FG36-08GO88161. This compilation has been uploaded to OSTI by DOE as a substitute for the required Final Technical Report, which was not submitted to DOE by NIREC or received by DOE. Project Objective: The primary goal of NIREC is to advance the transformation of the scientific innovation of the institutional partner’s research in renewable energy into a proof of the scientific concept eventually leading to viable businesses with cost effective solutions to accelerate the widespread adoption of renewable energy. NIREC will a) select research projects that are determined to have significant commercialization potential as a result of vetting by the Technology and commercialization Advisory Board, b) assign an experienced Entrepreneur-in-Residence (EIR) to each manage the scientific commercialization-preparedness process, and c) facilitate connectivity with venture capital and other private-sector capital sources to fund the rollout, scaling and growth of the resultant renewable energy business.

  12. Enabling a Community to Dissect an Organism: Overview of the Neurospora Functional Genomics Project

    OpenAIRE

    Dunlap, Jay C.; Borkovich, Katherine A.; Henn, Matthew R.; Turner, Gloria E.; Sachs, Matthew S.; Glass, N. Louise; McCluskey, Kevin; Plamann, Michael; Galagan, James E.; Birren, Bruce W.; Weiss, Richard L.; Townsend, Jeffrey P.; Loros, Jennifer J.; Nelson, Mary Anne; Lambreghts, Randy

    2007-01-01

    A consortium of investigators is engaged in a functional genomics project centered on the filamentous fungus Neurospora, with an eye to opening up the functional genomic analysis of all the filamentous fungi. The overall goal of the four interdependent projects in this effort is to acccomplish functional genomics, annotation, and expression analyses of Neurospora crassa, a filamentous fungus that is an established model for the assemblage of over 250,000 species of nonyeast fungi. Building fr...

  13. The Genomes On Line Database (GOLD) in 2009: status of genomic and metagenomic projects and their associated metadata

    Science.gov (United States)

    Liolios, Konstantinos; Chen, I-Min A.; Mavromatis, Konstantinos; Tavernarakis, Nektarios; Hugenholtz, Philip; Markowitz, Victor M.; Kyrpides, Nikos C.

    2010-01-01

    The Genomes On Line Database (GOLD) is a comprehensive resource for centralized monitoring of genome and metagenome projects worldwide. Both complete and ongoing projects, along with their associated metadata, can be accessed in GOLD through precomputed tables and a search page. As of September 2009, GOLD contains information for more than 5800 sequencing projects, of which 1100 have been completed and their sequence data deposited in a public repository. GOLD continues to expand, moving toward the goal of providing the most comprehensive repository of metadata information related to the projects and their organisms/environments in accordance with the Minimum Information about a (Meta)Genome Sequence (MIGS/MIMS) specification. GOLD is available at: http://www.genomesonline.org and has a mirror site at the Institute of Molecular Biology and Biotechnology, Crete, Greece, at: http://gold.imbb.forth.gr/ PMID:19914934

  14. Bat biology, genomes, and the Bat1K project

    DEFF Research Database (Denmark)

    Teeling, Emma C; Vernes, Sonja C; Dávalos, Liliana M

    2018-01-01

    and endangered. Here we announce Bat1K, an initiative to sequence the genomes of all living bat species (n∼1,300) to chromosome-level assembly. The Bat1K genome consortium unites bat biologists (>148 members as of writing), computational scientists, conservation organizations, genome technologists, and any...

  15. Final Status Survey for the Largest Decommissioning Project on Earth

    International Nuclear Information System (INIS)

    Dubiel, R.W.; Miller, J.; Quayle, D.

    2006-01-01

    To assist the United States Department of Energy's (US DOE's) re-industrialization efforts at its gaseous diffusion site in Oak Ridge, Tennessee, known as the East Tennessee Technology Park (ETTP), the US DOE awarded a 6-year Decontamination and Decommissioning (D and D) contract to BNG America (formerly BNFL Inc.) in 1997. The ETTP 3-Building D and D Project included the removal and disposition of the materials and equipment from the K-33, K-31, and K-29 Gaseous Diffusion Plant buildings. The three buildings comprise more than 4.8 million square feet (446,000 square meters) of floor surface area and more than 350 million pounds (148 million kilograms) of hazardous and radioactively contaminated material, making it the largest nuclear D and D project in progress anywhere in the world. The logistical hurdles involved in a project of this scope and magnitude required an extensive amount of Engineering and Health Physics professionals. In order to accomplish the Final Status Survey (FSS) for a project of this scope, the speed and efficiency of automated survey equipment was essential. Surveys of floors, structural steel and ceilings up to 60 feet (18 meters) were required. The FSS had to be expanded to include additional remediation and surveys due to characterization surveys and assumptions regarding the nature and extent of contamination provided by the US DOE. Survey design and technical bases had to consider highly variable constituents; including uranium from depleted to low enrichment, variable levels of Technetium-99 and transuranic nuclides, which were introduced into the cascade during the 1960's when recycled uranium (RU) from Savannah River was re-enriched at the facility. The RU was transported to unexpected locations from leaks in the cascade by complex building ventilation patterns. The primary survey tool used for the post remediation and FSS was the Surface Contamination Monitor (SCM) and the associated Survey Information Management System (SIMS

  16. Final project report: TA-35 Los Alamos Power Reactor Experiment No. II (LAPRE II) decommissioning project

    International Nuclear Information System (INIS)

    Montoya, G.M.

    1993-02-01

    This final report addresses the decommissioning of the LAPRE II Reactor, safety enclosure, fuel reservoir tanks, emergency fuel recovery system, primary pump pit, secondary loop, associated piping, and the post-remediation activities. Post-remedial action measurements are also included. The cost of the project including, Phase I assessment and Phase II remediation was approximately $496K. The decommissioning operation produced 533 M 3 of mixed waste

  17. Final project report, TA-35 Los Alamos Power Reactor Experiment No. II (LAPRE II) decommissioning project

    International Nuclear Information System (INIS)

    Montoya, G.M.

    1992-01-01

    This final report addresses the decommissioning of the LAPRE II Reactor, safety enclosure, fuel reservoir tanks, emergency fuel recovery system, primary pump pit, secondary loop, associated piping, and the post-remediation activities. Post-remedial action measurements are also included. The cost of the project, including Phase I assessment and Phase II remediation was approximately $496K. The decommissioning operation produced 533 m 3 of low-level solid radioactive waste and 5 m 3 of mixed waste

  18. NTRCI Legacy Engine Research and Development Project Final Technical Report

    Energy Technology Data Exchange (ETDEWEB)

    Smith-Holbert, Connie [National Transportation Research Center, Inc., Knoxville, TN (United States); Petrolino, Joseph [National Transportation Research Center, Inc., Knoxville, TN (United States); Watkins, Bart [Power Source Technologies Inc., Corvallis, OR (United States); Irick, David [Power Source Technologies Inc., Corvallis, OR (United States)

    2011-12-31

    The Legacy engine is a completely new design, transitional diesel engine, replacing the reciprocating engine with a rotary engine. The Legacy engine offers significant advances over conventional internal combustion engines in 1) power to weight ratio; 2) multiple fuel acceptance; 3) fuel economy; and 4) environmental compliance. These advances are achieved through a combination of innovative design geometry, rotary motion, aspiration simplicity, and manufacturing/part simplicity. The key technical challenge to the Legacy engine's commercialization, and the focus of this project, was the development of a viable roton tip seal. The PST concept for the roton tip seal was developed into a manufacturable design. The design was evaluated using a custom designed and fabricated seal test fixture and further refined. This design was incorporated into the GEN2.5A prototype and tested for achievable compression pressure. The Decision Point at the end of Phase 1 of the project (described below) was to further optimize the existing tip seal design. Enhancements to the tip seal design were incorporated into the GEN2.5B prototype and tested and evaluated using the iterative research strategy described below. Compression pressures adequate for compression ignition of diesel fuel were achieved, although not consistently in all combustion volumes. The variation in compression pressures was characterized versus design features. As the roton tip seal performance was improved, results pointed toward inadequate performance of the housing side seals. Enhancement of the housing side seal system was accomplished using a custom designed side seal test fixture. The design enhancements developed with the test fixture were also incorporated into the GEN2.5B prototype and tested and evaluated using the iterative research strategy described below. Finally, to simplify the requirements for the roton tip seals and to enhance the introduction and combustion of fuel, a flush-mount fuel injector

  19. Alligator Rivers Analogue Project. Final Report - Volume 1

    Energy Technology Data Exchange (ETDEWEB)

    Duerden, P [Australian Nuclear Science and Technology Organisation (ANSTO), Lucas Heights, NSW (Australia); Lever, D A [AEA Technology, Harwell (United Kingdom); Sverjensky, D A [Johns Hopkins Univ., Baltimore, MD (United States); Townley, L R [Commonwealth Scientific and Industrial Research Organisation (CSIRO), Wembley, WA (Australia). Div. of Water Resources

    1992-07-01

    This summary report, which highlights the work and findings of the Alligator Rivers Analogue Project (ARAP) is one of a series of 16 volumes, listed below. Detailed descriptions and results are provided in Volumes 2 to 16. Full acknowledgment to individual contributions is provided in the individual reports, and in Appendix I of this report. The findings from the technical studies are discussed in the context of assessments of the long-term performance of geological repositories for radioactive wastes, which are being undertaken in many countries. They are also considered in an integrated 'Scenario Development' approach, aimed to understand the formation of the ore deposit. Despite their inherent uncertainties, the findings provide a basis for assessing the way in which radionuclides will migrate in environments with a variety of geologic settings and over a range of different geologic timescales. Thus, section 2 of this report discusses the concept of using uranium deposits as natural analogues and refers to a number of such studies, including those at the Koongarra deposit in the Alligator Rivers Region of the Northern Territory of Australia. Section 3 reviews early scientific work in the Alligator Rivers Region and summarises the results of the analogue studies undertaken between 1981 and 1987 that were funded by the US Nuclear Regulatory Commission (USNRC) and the UK Department of the Environment (UKDoE). Section 4 describes the objectives of ARAP and the manner in which the study was conducted and provides a general outline of the project and a summary of the findings. A general description of the Koongarra ore deposit, the focus of ARAP, is provided in Section 5, with Sections 6-13 providing summaries of the work carried out to characterise the site in detail and provide data for modelling. Sections 14-18 discuss how this data was used in modelling and how the results may be applied for performance assessment studies. Finally, Section 19 considers the

  20. Alligator Rivers Analogue Project. Final Report - Volume 1

    International Nuclear Information System (INIS)

    Duerden, P.; Lever, D.A.; Sverjensky, D.A.; Townley, L.R.

    1992-01-01

    This summary report, which highlights the work and findings of the Alligator Rivers Analogue Project (ARAP) is one of a series of 16 volumes, listed below. Detailed descriptions and results are provided in Volumes 2 to 16. Full acknowledgment to individual contributions is provided in the individual reports, and in Appendix I of this report. The findings from the technical studies are discussed in the context of assessments of the long-term performance of geological repositories for radioactive wastes, which are being undertaken in many countries. They are also considered in an integrated 'Scenario Development' approach, aimed to understand the formation of the ore deposit. Despite their inherent uncertainties, the findings provide a basis for assessing the way in which radionuclides will migrate in environments with a variety of geologic settings and over a range of different geologic timescales. Thus, section 2 of this report discusses the concept of using uranium deposits as natural analogues and refers to a number of such studies, including those at the Koongarra deposit in the Alligator Rivers Region of the Northern Territory of Australia. Section 3 reviews early scientific work in the Alligator Rivers Region and summarises the results of the analogue studies undertaken between 1981 and 1987 that were funded by the US Nuclear Regulatory Commission (USNRC) and the UK Department of the Environment (UKDoE). Section 4 describes the objectives of ARAP and the manner in which the study was conducted and provides a general outline of the project and a summary of the findings. A general description of the Koongarra ore deposit, the focus of ARAP, is provided in Section 5, with Sections 6-13 providing summaries of the work carried out to characterise the site in detail and provide data for modelling. Sections 14-18 discuss how this data was used in modelling and how the results may be applied for performance assessment studies. Finally, Section 19 considers the

  1. CERTS Microgrid Laboratory Test Bed - PIER Final Project Report

    Energy Technology Data Exchange (ETDEWEB)

    Eto, Joseph H.; Eto, Joseph H.; Lasseter, Robert; Schenkman, Ben; Klapp, Dave; Linton, Ed; Hurtado, Hector; Roy, Jean; Lewis, Nancy Jo; Stevens, John; Volkommer, Harry

    2008-07-25

    The objective of the CERTS Microgrid Laboratory Test Bed project was to enhance the ease of integrating small energy sources into a microgrid. The project accomplished this objective by developing and demonstrating three advanced techniques, collectively referred to as the CERTS Microgrid concept, that significantly reduce the level of custom field engineering needed to operate microgrids consisting of small generating sources. The techniques comprising the CERTS Microgrid concept are: 1) a method for effecting automatic and seamless transitions between grid-connected and islanded modes of operation; 2) an approach to electrical protection within the microgrid that does not depend on high fault currents; and 3) a method for microgrid control that achieves voltage and frequency stability under islanded conditions without requiring high-speed communications. The techniques were demonstrated at a full-scale test bed built near Columbus, Ohio and operated by American Electric Power. The testing fully confirmed earlier research that had been conducted initially through analytical simulations, then through laboratory emulations, and finally through factory acceptance testing of individual microgrid components. The islanding and resychronization method met all Institute of Electrical and Electronics Engineers 1547 and power quality requirements. The electrical protections system was able to distinguish between normal and faulted operation. The controls were found to be robust and under all conditions, including difficult motor starts. The results from these test are expected to lead to additional testing of enhancements to the basic techniques at the test bed to improve the business case for microgrid technologies, as well to field demonstrations involving microgrids that involve one or mroe of the CERTS Microgrid concepts.

  2. TWTF project criticality task force final review and assessment

    International Nuclear Information System (INIS)

    McKinley, K.B.; Cannon, J.W.; Wheeler, F.J.; Worle, H.A.

    1980-11-01

    The Transuranic Waste Treatment Facility (TWTF) is being developed to process transuranic waste, stored and buried at the Idaho National Engineering Laboratory, into a chemically inert, physically stable basalt-like residue acceptable at a federal repository. A task force was assembled by the TWTF Project Division to review and assess all aspects of criticality safety for the TWTF. This document presents the final review, assessments, and recommendations of this task force. The following conclusions were made: Additional criticality studies are needed for the entire envelope of feed compositions and temperature effects. Safe operating k/sub eff/'s need to be determined for process components. Criticality analyses validation experiments may also be required. SRP neutron interrogation should be replaced by DDT neutron interrogation. Accuracy studies need to be performed for the proposed assaying techniques. Time-correlated neutron monitoring needs to be mocked up for process components to prove feasibility and determine accuracy. The criticality control techniques developed for the TWTF conceptual design are in compliance with ERDAM 0530, including the Double Contingency Rule. Detailed procedures and controls need to be developed

  3. ND-REAP/DOE cooperative project: final report

    Energy Technology Data Exchange (ETDEWEB)

    1979-01-01

    The impacts of energy-related developments in North Dakota are having profound effects on the state. Among the most significant of these effects are those on the state's economy and its population. Knowledge of the total environmental effects of development is a necessary prerequisite for effective planning and decision making. This final report addresses the conceptual design and functional evolution of the Regional Environmental Assessment Program, the results of the REAP/DOE Cooperative Effort, as well as evolution of the REAP/DOE effort and recommendations for future directions. The Economic Demographic (E-D) Model was developed to give North Dakota decision makers a tool with which to evaluate the impacts of coal development. It projects social, economic, and characteristics of North Dakota. Refinements and expansion of the model are discussed in Section 1. Section 2 provides an evaluation of the model as applied to other states. Section 3 identifies and evaluates the use of REAP data and capabilities to date. The REAP Resources Reference System R/sup 3/S was developed to provide access to information systems and to past research and present studies about aspects of North Dakota. It is a computer-based library reference system. Its status and expansion potential is covered in Section 4. Section 5 makes recommendations for future efforts.

  4. Project Familia. Final Evaluation Report, 1993-94. OER Report.

    Science.gov (United States)

    New York City Board of Education, Brooklyn, NY. Office of Educational Research.

    Project Familia was an Elementary and Secondary Education Act Title VII project in its second year in 1993-94 in New York City. Project Familia served 77 children at 3 schools who were identified as limited English proficient, special education students in prekindergarten through fifth grade and their parents. The project provided after-school…

  5. The Genomes OnLine Database (GOLD) v.4: status of genomic and metagenomic projects and their associated metadata

    Science.gov (United States)

    Pagani, Ioanna; Liolios, Konstantinos; Jansson, Jakob; Chen, I-Min A.; Smirnova, Tatyana; Nosrat, Bahador; Markowitz, Victor M.; Kyrpides, Nikos C.

    2012-01-01

    The Genomes OnLine Database (GOLD, http://www.genomesonline.org/) is a comprehensive resource for centralized monitoring of genome and metagenome projects worldwide. Both complete and ongoing projects, along with their associated metadata, can be accessed in GOLD through precomputed tables and a search page. As of September 2011, GOLD, now on version 4.0, contains information for 11 472 sequencing projects, of which 2907 have been completed and their sequence data has been deposited in a public repository. Out of these complete projects, 1918 are finished and 989 are permanent drafts. Moreover, GOLD contains information for 340 metagenome studies associated with 1927 metagenome samples. GOLD continues to expand, moving toward the goal of providing the most comprehensive repository of metadata information related to the projects and their organisms/environments in accordance with the Minimum Information about any (x) Sequence specification and beyond. PMID:22135293

  6. Rhipicephalus (Boophilus) microplus strain Deutsch, whole genome shotgun sequencing project first submission of genome sequence

    Science.gov (United States)

    The size and repetitive nature of the Rhipicephalus microplus genome makes obtaining a full genome sequence difficult. Cot filtration/selection techniques were used to reduce the repetitive fraction of the tick genome and enrich for the fraction of DNA with gene-containing regions. The Cot-selected ...

  7. Final report Hanford environmental compliance project 89-D-172

    International Nuclear Information System (INIS)

    Kelly, J.R.

    1996-01-01

    The Hanford Environmental Compliance (HEC) Project is unique in that it consisted of 14 subprojects which varied in project scope and were funded from more that one program. This report describes the HEC Project from inception to completion and the scope, schedule, and cost of the individual subprojects. Also provided are the individual subproject Cost closing statements and Project completion reports accompanied by construction photographs and illustrations

  8. Final environmental impact statement, Beaufort Sea oil and gas development/Northstar Project. Appendix A: BP Exploration (Alaska) Inc. Final project description - Revision 1, March 27, 1997

    International Nuclear Information System (INIS)

    1999-02-01

    BP Exploration (Alaska) Inc. (BPXA) submitted a permit application to the US Army Engineer District, Alaska to initiate the review process for BPXA's plans to develop and produce oil and gas from the Northstar Unit. This report contains Appendix A of an Environmental Impact Statement which was undertaken to identify and evaluate the potential effects the proposed project may have on the environment. This document is the Northstar Development Project, Final Project Description, Revision 1 for BPXA Northstar Project

  9. The Workplace Literacy System Project (WLS). Final Performance Report.

    Science.gov (United States)

    Poulton, Bruce R.

    The Workplace Literacy System Project (WLS) prepared interactive CD-ROM discs containing about 50 hours of instruction and drill in basic skills presented within the context of the textile/apparel manufacturing industry. The project was conducted at a Sara Lee knit products plant in North Carolina. During the project, literacy task analyses were…

  10. Project Aprendizaje. 1990-91 Final Evaluation Profile. OREA Report.

    Science.gov (United States)

    New York City Board of Education, Brooklyn, NY. Office of Research, Evaluation, and Assessment.

    An evaluation was done of New York City Public Schools' Project Aprendizaje, which served disadvantaged, immigrant, Spanish-speaking high school students at Seward Park High School in Manhattan. The Project enrolled 290 students in grades 9 through 12, 93.1 percent of whom were eligible for the Free Lunch Program. The Project provided students of…

  11. Matching phenotypes to whole genomes: Lessons learned from four iterations of the personal genome project community challenges.

    Science.gov (United States)

    Cai, Binghuang; Li, Biao; Kiga, Nikki; Thusberg, Janita; Bergquist, Timothy; Chen, Yun-Ching; Niknafs, Noushin; Carter, Hannah; Tokheim, Collin; Beleva-Guthrie, Violeta; Douville, Christopher; Bhattacharya, Rohit; Yeo, Hui Ting Grace; Fan, Jean; Sengupta, Sohini; Kim, Dewey; Cline, Melissa; Turner, Tychele; Diekhans, Mark; Zaucha, Jan; Pal, Lipika R; Cao, Chen; Yu, Chen-Hsin; Yin, Yizhou; Carraro, Marco; Giollo, Manuel; Ferrari, Carlo; Leonardi, Emanuela; Tosatto, Silvio C E; Bobe, Jason; Ball, Madeleine; Hoskins, Roger A; Repo, Susanna; Church, George; Brenner, Steven E; Moult, John; Gough, Julian; Stanke, Mario; Karchin, Rachel; Mooney, Sean D

    2017-09-01

    The advent of next-generation sequencing has dramatically decreased the cost for whole-genome sequencing and increased the viability for its application in research and clinical care. The Personal Genome Project (PGP) provides unrestricted access to genomes of individuals and their associated phenotypes. This resource enabled the Critical Assessment of Genome Interpretation (CAGI) to create a community challenge to assess the bioinformatics community's ability to predict traits from whole genomes. In the CAGI PGP challenge, researchers were asked to predict whether an individual had a particular trait or profile based on their whole genome. Several approaches were used to assess submissions, including ROC AUC (area under receiver operating characteristic curve), probability rankings, the number of correct predictions, and statistical significance simulations. Overall, we found that prediction of individual traits is difficult, relying on a strong knowledge of trait frequency within the general population, whereas matching genomes to trait profiles relies heavily upon a small number of common traits including ancestry, blood type, and eye color. When a rare genetic disorder is present, profiles can be matched when one or more pathogenic variants are identified. Prediction accuracy has improved substantially over the last 6 years due to improved methodology and a better understanding of features. © 2017 Wiley Periodicals, Inc.

  12. The pig genome project has plenty to squeal about.

    Science.gov (United States)

    Fan, B; Gorbach, D M; Rothschild, M F

    2011-01-01

    Significant progress on pig genetics and genomics research has been witnessed in recent years due to the integration of advanced molecular biology techniques, bioinformatics and computational biology, and the collaborative efforts of researchers in the swine genomics community. Progress on expanding the linkage map has slowed down, but the efforts have created a higher-resolution physical map integrating the clone map and BAC end sequence. The number of QTL mapped is still growing and most of the updated QTL mapping results are available through PigQTLdb. Additionally, expression studies using high-throughput microarrays and other gene expression techniques have made significant advancements. The number of identified non-coding RNAs is rapidly increasing and their exact regulatory functions are being explored. A publishable draft (build 10) of the swine genome sequence was available for the pig genomics community by the end of December 2010. Build 9 of the porcine genome is currently available with Ensembl annotation; manual annotation is ongoing. These drafts provide useful tools for such endeavors as comparative genomics and SNP scans for fine QTL mapping. A recent community-wide effort to create a 60K porcine SNP chip has greatly facilitated whole-genome association analyses, haplotype block construction and linkage disequilibrium mapping, which can contribute to whole-genome selection. The future 'systems biology' that integrates and optimizes the information from all research levels can enhance the pig community's understanding of the full complexity of the porcine genome. These recent technological advances and where they may lead are reviewed. Copyright © 2011 S. Karger AG, Basel.

  13. El Paso County Geothermal Project at Fort Bliss. Final Project Report

    Energy Technology Data Exchange (ETDEWEB)

    Lear, Jon [Ruby Mountain Inc., Salt Lake City, UT (United State); Bennett, Carlon [Ruby Mountain Inc., Salt Lake City, UT (United State); Lear, Dan [Ruby Mountain Inc., Salt Lake City, UT (United State); Jones, Phil L. [Ruby Mountain Inc., Salt Lake City, UT (United State); Burdge, Mark [Evergreen Clean Energy Management, Provo, UT (United States); Barker, Ben [Evergreen Clean Energy Management, Provo, UT (United States); Segall, Marylin [Univ. of Utah, Salt Lake City, UT (United States). Energy and Geoscience Inst.; Moore, Joseph [Univ. of Utah, Salt Lake City, UT (United States). Energy and Geoscience Inst.; Nash, Gregory [Univ. of Utah, Salt Lake City, UT (United States). Energy and Geoscience Inst.; Jones, Clay [Univ. of Utah, Salt Lake City, UT (United States). Energy and Geoscience Inst.; Simmons, Stuart [Univ. of Utah, Salt Lake City, UT (United States). Energy and Geoscience Inst.; Taylor, Nancy [Univ. of Utah, Salt Lake City, UT (United States). Energy and Geoscience Inst.

    2016-02-01

    The El Paso County Geothermal Project at Fort Bliss was an effort to determine the scale and scope of geothermal resources previously identified on Fort Bliss’ McGregor Range in southern Otero County, New Mexico. The project was funded with a $5,000,000 grant to El Paso County from the U.S. Department of Energy (DOE) as part of the American Recovery and Reinvestment Act of 2009 and a $4,812,500 match provided by private sector partners. The project was administered through the DOE Golden Field Office to awardee El Paso County. The primary subcontractor to El Paso County and project Principal Investigator - Ruby Mountain Inc. (RMI) of Salt Lake City, Utah - assembled the project team consisting of Evergreen Clean Energy Management (ECEM) of Provo, Utah, and the Energy & Geoscience Institute at the University of Utah (EGI) in Salt Lake City, UT to complete the final phases of the project. The project formally began in May of 2010 and consisted of two preliminary phases of data collection and evaluation which culminated in the identification of a drilling site for a Resource Confirmation Well on McGregor Range. Well RMI 56-5 was drilled May and June 2013 to a depth of 3,030 ft. below ground level. A string of slotted 7 inch casing was set in 8.75 inch hole on bottom fill at 3,017 ft. to complete the well. The well was drilled using a technique called flooded reverse circulation, which is most common in mineral exploration. This technique produced an exceptionally large and complete cuttings record. An exciting development at the conclusion of drilling was the suspected discovery of a formation that has proven to be of exceptionally high permeability in three desalinization wells six miles to the south. Following drilling and preliminary testing and analysis, the project team has determined that the McGregor Range thermal anomaly is large and can probably support development in the tens of megawatts.

  14. Understanding the Human Genome Project — A Fact Sheet | NIH MedlinePlus the Magazine

    Science.gov (United States)

    ... The Human Genome Project spurred a revolution in biotechnology innovation around the world and played a key ... the U.S. the global leader in the new biotechnology sector. In April 2003, researchers successfully completed the ...

  15. Industrial Sites Project Establishment of Final Action Levels

    International Nuclear Information System (INIS)

    Boehlecke, Robert F.

    2006-01-01

    The U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office (NNSA/NSO) oversees numerous sites on the Nevada Test Site (NTS) and other locations in the State of Nevada that have been impacted by activities related to the development and testing of nuclear devices and by other activities. NNSA/NSO is responsible for protecting members of the public, including site workers, from harmful exposure to both chemical and radiological contaminants at these sites as they remediate these sites. The Nevada Division of Environmental Protection (NDEP) is the primary state agency responsible for protection of human health and the environment with respect to chemical and radiological wastes. In 1996 the DOE, U.S. Department of Defense, and the State of Nevada entered into an agreement known as the ''Federal Facility Agreement and Consent Order'' (FFACO) (1996). Appendix VI to the FFACO describes the strategy employed to plan, implement, and complete environmental corrective action activities at NTS and other locations in the state of Nevada. One of the categories of corrective action units (CAUs) is Industrial Sites, which consists of approximately 1,150 locations that may require some level of investigation and corrective action. To evaluate the need for the extent of corrective action at a particular site, NNSA/NSO assesses the potential impacts to receptors by comparing measurements of contaminant concentrations to risk-based (chemical) and dose-based (radionuclide) standards (action levels). Preliminary action levels (PALs) are established as part of the data quality objective (DQO) process, and are presented in one or more FFACO documents generated as part of the corrective action process. This document formally defines and clarifies the NDEP-approved process NNSA/NSO Industrial Sites Project uses to fulfill the requirements of the FFACO and state regulations. This process establishes final action levels (FALs) based on the risk

  16. WindFloat Pacific Project, Final Scientific and Technical Report

    Energy Technology Data Exchange (ETDEWEB)

    Banister, Kevin [Principle Power, Inc., Emeryville, CA (United States)

    2017-01-17

    PPI’s WindFloat Pacific project (WFP) was an up to 30 MW floating offshore wind demonstration project proposed off the Coast of Oregon. The project was to be sited approximately 18 miles due west of Coos Bay, in over 1000 ft. of water, and is the first floating offshore wind array proposed in the United States, and the first offshore wind project of any kind proposed off the West Coast. PPI’s WindFloat, a semi-submersible foundation designed for high-capacity (6MW+) offshore wind turbines, is at the heart of the proposed project, and enables access to the world class wind resource at the project site and, equally, to other deep water, high wind resource areas around the country.

  17. National human genome projects: an update and an agenda

    OpenAIRE

    An, Joon Yong

    2017-01-01

    Population genetic and human genetic studies are being accelerated with genome technology and data sharing. Accordingly, in the past 10 years, several countries have initiated genetic research using genome technology and identified the genetic architecture of the ethnic groups living in the corresponding country or suggested the genetic foundation of a social phenomenon. Genetic research has been conducted from epidemiological studies that previously described the health or disease conditions...

  18. Final Report for NMBSA Project, Monika Kaden, 2016

    Energy Technology Data Exchange (ETDEWEB)

    Ward, William Carl [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2016-12-13

    The following pages define the objectives and results for Project 022, requested by Monika Kaden, a sculptor who maintains studios in Santa Fe. This effort was first approved in February 2016, and was completed during several different time segments spread over the year, depending on Monika’s availability. The project deliverables that are of primary use to the customer are digital data files that are to be delivered electronically. This report is a summary overview of how the project was conducted.

  19. Wabash River Coal Gasification Repowering Project: A DOE Assessment; FINAL

    International Nuclear Information System (INIS)

    National Energy Technology Laboratory

    2002-01-01

    The goal of the U.S. Department of Energy (DOE) Clean Coal Technology Program (CCT) is to furnish the energy marketplace with a number of advanced, more efficient, and environmentally responsible coal utilization technologies through demonstration projects. These projects seek to establish the commercial feasibility of the most promising advanced coal technologies that have developed beyond the proof-of-concept stage. This document serves as a DOE post-project assessment (PPA) of a project selected in CCT Round IV, the Wabash River Coal Gasification Repowering (WRCGR) Project, as described in a Report to Congress (U.S. Department of Energy 1992). Repowering consists of replacing an existing coal-fired boiler with one or more clean coal technologies to achieve significantly improved environmental performance. The desire to demonstrate utility repowering with a two-stage, pressurized, oxygen-blown, entrained-flow, integrated gasification combined-cycle (IGCC) system prompted Destec Energy, Inc., and PSI Energy, Inc., to form a joint venture and submit a proposal for this project. In July 1992, the Wabash River Coal Gasification Repowering Project Joint Venture (WRCGRPJV, the Participant) entered into a cooperative agreement with DOE to conduct this project. The project was sited at PSI Energy's Wabash River Generating Station, located in West Terre Haute, Indiana. The purpose of this CCT project was to demonstrate IGCC repowering using a Destec gasifier and to assess long-term reliability, availability, and maintainability of the system at a fully commercial scale. DOE provided 50 percent of the total project funding (for capital and operating costs during the demonstration period) of$438 million

  20. Project Familia. Final Evaluation Report, 1992-93. OREA Report.

    Science.gov (United States)

    Clarke, Candice

    Project Familia was an Elementary and Secondary Education Act Title VII funded project that, in the year covered by this evaluation, served 41 special education students of limited English proficiency (LEP) from 5 schools, with the participation of 54 parents and 33 siblings. Participating students received English language enrichment and…

  1. Project Aprendizaje. Final Evaluation Report 1992-93.

    Science.gov (United States)

    Clark, Andrew

    This report provides evaluative information regarding the effectiveness of Project Aprendizaje, a New York City program that served 269 Spanish-speaking students of limited English proficiency (LEP). The project promoted parent and community involvement by sponsoring cultural events, such as a large Latin American festival. Students developed…

  2. Rural Math Excel Partnership (RMEP) Project Final Performance Report

    Science.gov (United States)

    Harmon, Hobart; Tate, Veronica; Stevens, Jennifer; Wilborn, Sandy; Adams, Sue

    2018-01-01

    The goal of the Rural Math Excel Partnership (RMEP) project, a development project funded by the U.S. Department of Education Investing in Innovation (i3) grant program, was to develop a model of shared responsibility among families, teachers, and communities in rural areas as collective support for student success in and preparation for advanced…

  3. Research Applications for Teaching (RAFT) Project. Final Report.

    Science.gov (United States)

    Thomson, James R., Jr.; Handley, Herbert M.

    A report is given of the development and progress of the Research Applications for Teaching (RAFT) project, developed at Mississippi State University. Based upon research findings relative to effective teaching and effective schooling, five curriculum modules were prepared and implemented in instruction. In the second year of the project the…

  4. Alpena Community College Workplace Partnership Project. Final Report.

    Science.gov (United States)

    Alpena Community Coll., MI.

    This document consists of materials produced during the Workplace Partnership Project (WPP), a National Workplace Literacy Program-funded workplace literacy partnership between Alpena Community College (ACC) in Alpena, Michigan, and area businesses. Presented first is a personal reflection in which the project director shares some of the lessons…

  5. Lower Columbia River Terminal Fisheries Research Project : Final Environmental Assessment.

    Energy Technology Data Exchange (ETDEWEB)

    United States. Bonneville Power Administration.

    1995-04-01

    This notice announces BPA`S`s decision to fund the Oregon Department of Fish and Wildlife (ODFW), the Washington Department of Fish and Wildlife (WDFW), and the Clatsop Economic Development Committee for the Lower Columbia River Terminal Fisheries Research Project (Project). The Project will continue the testing of various species/stocks, rearing regimes, and harvest options for terminal fisheries, as a means to increase lower river sport and commercial harvest of hatchery fish, while providing both greater protection of weaker wild stocks and increasing the return of upriver salmon runs to potential Zone 6 Treaty fisheries. The Project involves relocating hatchery smolts to new, additional pen locations in three bays/sloughs in the lower Columbia River along both the Oregon and Washington sides. The sites are Blind Slough and Tongue Point in Clatsop County, Oregon, and Grays Bay/Deep River, Wahkiakum County, Washington. The smolts will be acclimated for various lengths of time in the net pens and released from these sites. The Project will expand upon an existing terminal fisheries project in Youngs Bay, Oregon. The Project may be expanded to other sites in the future, depending on the results of this initial expansion. BPA`S has determined the project is not a major Federal action significantly affecting the quality of the human environment, within the meaning of the National Environmental Policy Act (NEPA) of 1969. Therefore, the preparation of an environmental impact statement is not required, and BPA`S is issuing this FONSI.

  6. 76 FR 64085 - Post-2014 Resource Pool-Loveland Area Projects, Final Power Allocation

    Science.gov (United States)

    2011-10-17

    ... Resource Pool; Loveland Area Projects, General Eligibility Criteria. The resource pool for capacity and... transmission in Kansas. Final allocation of the Post-2014 Resource Pool; Loveland Area Projects, is contingent...

  7. Increasing Prediction the Original Final Year Project of Student Using Genetic Algorithm

    Science.gov (United States)

    Saragih, Rijois Iboy Erwin; Turnip, Mardi; Sitanggang, Delima; Aritonang, Mendarissan; Harianja, Eva

    2018-04-01

    Final year project is very important forgraduation study of a student. Unfortunately, many students are not seriouslydidtheir final projects. Many of studentsask for someone to do it for them. In this paper, an application of genetic algorithms to predict the original final year project of a studentis proposed. In the simulation, the data of the final project for the last 5 years is collected. The genetic algorithm has several operators namely population, selection, crossover, and mutation. The result suggest that genetic algorithm can do better prediction than other comparable model. Experimental results of predicting showed that 70% was more accurate than the previous researched.

  8. The Human Genome Project: applications in the diagnosis and treatment of neurologic disease.

    Science.gov (United States)

    Evans, G A

    1998-10-01

    The Human Genome Project (HGP), an international program to decode the entire DNA sequence of the human genome in 15 years, represents the largest biological experiment ever conducted. This set of information will contain the blueprint for the construction and operation of a human being. While the primary driving force behind the genome project is the potential to vastly expand the amount of genetic information available for biomedical research, the ramifications for other fields of study in biological research, the biotechnology and pharmaceutical industry, our understanding of evolution, effects on agriculture, and implications for bioethics are likely to be profound.

  9. Austin Children`s Museum ``Go Power`` project. Final report

    Energy Technology Data Exchange (ETDEWEB)

    1993-10-01

    Go Power, was conceived as an interactive exhibit and related set of activities designed to promote in children and families an understanding and appreciation of energy concepts. Planned in 1990, the project culminated its first phase of activities with colorful, interactive exhibit about the pathways and transformations of energy, on display at the Austin Children`s Museum between February 5th and June 6th, 1993. The project was supported by the US Department of Energy, the National Science Foundation, the Lower Colorado River Authority and various local foundations and businesses. This report describes the process, product and outcomes of this project.

  10. Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project.

    Science.gov (United States)

    Birney, Ewan; Stamatoyannopoulos, John A; Dutta, Anindya; Guigó, Roderic; Gingeras, Thomas R; Margulies, Elliott H; Weng, Zhiping; Snyder, Michael; Dermitzakis, Emmanouil T; Thurman, Robert E; Kuehn, Michael S; Taylor, Christopher M; Neph, Shane; Koch, Christoph M; Asthana, Saurabh; Malhotra, Ankit; Adzhubei, Ivan; Greenbaum, Jason A; Andrews, Robert M; Flicek, Paul; Boyle, Patrick J; Cao, Hua; Carter, Nigel P; Clelland, Gayle K; Davis, Sean; Day, Nathan; Dhami, Pawandeep; Dillon, Shane C; Dorschner, Michael O; Fiegler, Heike; Giresi, Paul G; Goldy, Jeff; Hawrylycz, Michael; Haydock, Andrew; Humbert, Richard; James, Keith D; Johnson, Brett E; Johnson, Ericka M; Frum, Tristan T; Rosenzweig, Elizabeth R; Karnani, Neerja; Lee, Kirsten; Lefebvre, Gregory C; Navas, Patrick A; Neri, Fidencio; Parker, Stephen C J; Sabo, Peter J; Sandstrom, Richard; Shafer, Anthony; Vetrie, David; Weaver, Molly; Wilcox, Sarah; Yu, Man; Collins, Francis S; Dekker, Job; Lieb, Jason D; Tullius, Thomas D; Crawford, Gregory E; Sunyaev, Shamil; Noble, William S; Dunham, Ian; Denoeud, France; Reymond, Alexandre; Kapranov, Philipp; Rozowsky, Joel; Zheng, Deyou; Castelo, Robert; Frankish, Adam; Harrow, Jennifer; Ghosh, Srinka; Sandelin, Albin; Hofacker, Ivo L; Baertsch, Robert; Keefe, Damian; Dike, Sujit; Cheng, Jill; Hirsch, Heather A; Sekinger, Edward A; Lagarde, Julien; Abril, Josep F; Shahab, Atif; Flamm, Christoph; Fried, Claudia; Hackermüller, Jörg; Hertel, Jana; Lindemeyer, Manja; Missal, Kristin; Tanzer, Andrea; Washietl, Stefan; Korbel, Jan; Emanuelsson, Olof; Pedersen, Jakob S; Holroyd, Nancy; Taylor, Ruth; Swarbreck, David; Matthews, Nicholas; Dickson, Mark C; Thomas, Daryl J; Weirauch, Matthew T; Gilbert, James; Drenkow, Jorg; Bell, Ian; Zhao, XiaoDong; Srinivasan, K G; Sung, Wing-Kin; Ooi, Hong Sain; Chiu, Kuo Ping; Foissac, Sylvain; Alioto, Tyler; Brent, Michael; Pachter, Lior; Tress, Michael L; Valencia, Alfonso; Choo, Siew Woh; Choo, Chiou Yu; Ucla, Catherine; Manzano, Caroline; Wyss, Carine; Cheung, Evelyn; Clark, Taane G; Brown, James B; Ganesh, Madhavan; Patel, Sandeep; Tammana, Hari; Chrast, Jacqueline; Henrichsen, Charlotte N; Kai, Chikatoshi; Kawai, Jun; Nagalakshmi, Ugrappa; Wu, Jiaqian; Lian, Zheng; Lian, Jin; Newburger, Peter; Zhang, Xueqing; Bickel, Peter; Mattick, John S; Carninci, Piero; Hayashizaki, Yoshihide; Weissman, Sherman; Hubbard, Tim; Myers, Richard M; Rogers, Jane; Stadler, Peter F; Lowe, Todd M; Wei, Chia-Lin; Ruan, Yijun; Struhl, Kevin; Gerstein, Mark; Antonarakis, Stylianos E; Fu, Yutao; Green, Eric D; Karaöz, Ulaş; Siepel, Adam; Taylor, James; Liefer, Laura A; Wetterstrand, Kris A; Good, Peter J; Feingold, Elise A; Guyer, Mark S; Cooper, Gregory M; Asimenos, George; Dewey, Colin N; Hou, Minmei; Nikolaev, Sergey; Montoya-Burgos, Juan I; Löytynoja, Ari; Whelan, Simon; Pardi, Fabio; Massingham, Tim; Huang, Haiyan; Zhang, Nancy R; Holmes, Ian; Mullikin, James C; Ureta-Vidal, Abel; Paten, Benedict; Seringhaus, Michael; Church, Deanna; Rosenbloom, Kate; Kent, W James; Stone, Eric A; Batzoglou, Serafim; Goldman, Nick; Hardison, Ross C; Haussler, David; Miller, Webb; Sidow, Arend; Trinklein, Nathan D; Zhang, Zhengdong D; Barrera, Leah; Stuart, Rhona; King, David C; Ameur, Adam; Enroth, Stefan; Bieda, Mark C; Kim, Jonghwan; Bhinge, Akshay A; Jiang, Nan; Liu, Jun; Yao, Fei; Vega, Vinsensius B; Lee, Charlie W H; Ng, Patrick; Shahab, Atif; Yang, Annie; Moqtaderi, Zarmik; Zhu, Zhou; Xu, Xiaoqin; Squazzo, Sharon; Oberley, Matthew J; Inman, David; Singer, Michael A; Richmond, Todd A; Munn, Kyle J; Rada-Iglesias, Alvaro; Wallerman, Ola; Komorowski, Jan; Fowler, Joanna C; Couttet, Phillippe; Bruce, Alexander W; Dovey, Oliver M; Ellis, Peter D; Langford, Cordelia F; Nix, David A; Euskirchen, Ghia; Hartman, Stephen; Urban, Alexander E; Kraus, Peter; Van Calcar, Sara; Heintzman, Nate; Kim, Tae Hoon; Wang, Kun; Qu, Chunxu; Hon, Gary; Luna, Rosa; Glass, Christopher K; Rosenfeld, M Geoff; Aldred, Shelley Force; Cooper, Sara J; Halees, Anason; Lin, Jane M; Shulha, Hennady P; Zhang, Xiaoling; Xu, Mousheng; Haidar, Jaafar N S; Yu, Yong; Ruan, Yijun; Iyer, Vishwanath R; Green, Roland D; Wadelius, Claes; Farnham, Peggy J; Ren, Bing; Harte, Rachel A; Hinrichs, Angie S; Trumbower, Heather; Clawson, Hiram; Hillman-Jackson, Jennifer; Zweig, Ann S; Smith, Kayla; Thakkapallayil, Archana; Barber, Galt; Kuhn, Robert M; Karolchik, Donna; Armengol, Lluis; Bird, Christine P; de Bakker, Paul I W; Kern, Andrew D; Lopez-Bigas, Nuria; Martin, Joel D; Stranger, Barbara E; Woodroffe, Abigail; Davydov, Eugene; Dimas, Antigone; Eyras, Eduardo; Hallgrímsdóttir, Ingileif B; Huppert, Julian; Zody, Michael C; Abecasis, Gonçalo R; Estivill, Xavier; Bouffard, Gerard G; Guan, Xiaobin; Hansen, Nancy F; Idol, Jacquelyn R; Maduro, Valerie V B; Maskeri, Baishali; McDowell, Jennifer C; Park, Morgan; Thomas, Pamela J; Young, Alice C; Blakesley, Robert W; Muzny, Donna M; Sodergren, Erica; Wheeler, David A; Worley, Kim C; Jiang, Huaiyang; Weinstock, George M; Gibbs, Richard A; Graves, Tina; Fulton, Robert; Mardis, Elaine R; Wilson, Richard K; Clamp, Michele; Cuff, James; Gnerre, Sante; Jaffe, David B; Chang, Jean L; Lindblad-Toh, Kerstin; Lander, Eric S; Koriabine, Maxim; Nefedov, Mikhail; Osoegawa, Kazutoyo; Yoshinaga, Yuko; Zhu, Baoli; de Jong, Pieter J

    2007-06-14

    We report the generation and analysis of functional data from multiple, diverse experiments performed on a targeted 1% of the human genome as part of the pilot phase of the ENCODE Project. These data have been further integrated and augmented by a number of evolutionary and computational analyses. Together, our results advance the collective knowledge about human genome function in several major areas. First, our studies provide convincing evidence that the genome is pervasively transcribed, such that the majority of its bases can be found in primary transcripts, including non-protein-coding transcripts, and those that extensively overlap one another. Second, systematic examination of transcriptional regulation has yielded new understanding about transcription start sites, including their relationship to specific regulatory sequences and features of chromatin accessibility and histone modification. Third, a more sophisticated view of chromatin structure has emerged, including its inter-relationship with DNA replication and transcriptional regulation. Finally, integration of these new sources of information, in particular with respect to mammalian evolution based on inter- and intra-species sequence comparisons, has yielded new mechanistic and evolutionary insights concerning the functional landscape of the human genome. Together, these studies are defining a path for pursuit of a more comprehensive characterization of human genome function.

  11. Final Project Report for "Interfacial Thermal Resistance of Carbon Nanotubes”

    Energy Technology Data Exchange (ETDEWEB)

    Cumings, John [Univ. of Maryland, College Park, MD (United States)

    2016-04-15

    This report describes an ongoing project to comprehensively study the interfacial thermal boundary resistance (Kapitza resistance) of carbon nanotubes. It includes a list of publications, personnel supported, the overall approach, accomplishments and future plans.

  12. Legacy sample disposition project. Volume 2: Final report

    International Nuclear Information System (INIS)

    Gurley, R.N.; Shifty, K.L.

    1998-02-01

    This report describes the legacy sample disposition project at the Idaho Engineering and Environmental Laboratory (INEEL), which assessed Site-wide facilities/areas to locate legacy samples and owner organizations and then characterized and dispositioned these samples. This project resulted from an Idaho Department of Environmental Quality inspection of selected areas of the INEEL in January 1996, which identified some samples at the Test Reactor Area and Idaho Chemical Processing Plant that had not been characterized and dispositioned according to Resource Conservation and Recovery Act (RCRA) requirements. The objective of the project was to manage legacy samples in accordance with all applicable environmental and safety requirements. A systems engineering approach was used throughout the project, which included collecting the legacy sample information and developing a system for amending and retrieving the information. All legacy samples were dispositioned by the end of 1997. Closure of the legacy sample issue was achieved through these actions

  13. Final report : Dallas Integrated Corridor Management (ICM) Demonstration Project.

    Science.gov (United States)

    2015-08-01

    The Dallas Area Rapid Transit (DART) is leading the US-75 Integrated Corridor Management (ICM) Demonstration Project for the Dallas region. Coordinated corridor operations and management is predicated on being able to share transportation information...

  14. Electric vehicle life cycle cost analysis : final research project report.

    Science.gov (United States)

    2017-02-01

    This project compared total life cycle costs of battery electric vehicles (BEV), plug-in hybrid electric vehicles (PHEV), hybrid electric vehicles (HEV), and vehicles with internal combustion engines (ICE). The analysis considered capital and operati...

  15. Final report investigation project agricultural products and environment

    International Nuclear Information System (INIS)

    Loria, L.G.; Jimenez Dam, R.; Mora Rodriguez, P.

    1998-01-01

    The document presents the after-action report on six investigation projects: Thermoluminescence, Spectrometry gamma of low level, Agricultural products, Radon in the subsoil, Nuclear instrumentation, and X-ray fluorescence, executed between 1995-1997 by the Laboratory of Physical Nuclear Applied of the University of Costa Rica, in the which objectives are shown, applied methodology as well as the achievements and results each project. (Author) [es

  16. SDC Supplier Obligation project : household energy from 2011 : final report

    OpenAIRE

    Sustainable Development Commission

    2008-01-01

    This report is based on 'SDC Supplier Obligation engagement project : process plan'. Evaluation of the engagement process used in this report can be found in 'SDC Supplier Obligation project : an evaluation of the Sustainable Development Commission's stakeholder and public engagement process'. This report presents the findings of the Sustainable Development Commission’s stakeholder and public engagement process and informs the development of Department for Environment, Food and Rural Af...

  17. Final Report - Navajo Electrification Demonstration Project - FY2004

    Energy Technology Data Exchange (ETDEWEB)

    Kenneth L. Craig, Interim General Manager

    2007-03-31

    The Navajo Electrification Demonstration Project (NEDP) is a multi-year projects which addresses the needs of unserved Navajo Nation residents without basic electricity services. The Navajo Nation is the United States' largest tribe, in terms of population and land. An estimated 18,000 Navajo Nation homes do not have basic grid-tied electricity--and this third year of funding, known as NEDP-3, provided 351 power line extensions to Navajo families.

  18. Hydrogen demonstration projects options in the Netherlands. Final report

    International Nuclear Information System (INIS)

    Bergsma, G.C.; Van der Werff, T.T.; Rooijers, F.J.

    1996-01-01

    Based on a survey of hydrogen demonstration projects, contacts with different actors and discussions in a sounding board for the study on the title subject, it is concluded that a conference can be organized where the possibilities of setting up hydrogen demonstration projects in the Netherlands can be discussed. The following projects offer good chances to be realized in the next few years: large-scale CO 2 storage in the underground, applying enhanced gas recovery. It appears to be a relatively cheap CO 2 emission reduction measure with a large potential. It can be combined with a hydrogen mixing project with the sale of hydrogen as a so-called eco-gas to consumers. There is little interest in the other options for CO 2 storage at coal gasification and the prompt supply of 100% H 2 to small-scale consumers. Hydrogen for cogeneration, fuel cells in the industry, hydrogen in road transport and hydrogen as a storage medium are projects in which some actors are interested. Hydrogen for air transport has a large potential to which only few parties in the Netherlands can anticipate. Hydrogen demonstration projects will show important surplus value when it is supported by a hydrogen research program. Such a program can be carried out in cooperation with several other programmes of the International Energy Agency, in Japan, Germany and a number of research programs of the Netherlands Agency for Energy and the Environment (Novem). 10 figs., 4 tabs., 33 refs

  19. [The final situation in the Turkey "Stent for Life" project].

    Science.gov (United States)

    Ertaş, Gökhan; Kozan, Omer; Değertekin, Muzaffer; Kervan, Umit; Aksoy, Mehmet; Koç, Orhan; Göktekin, Omer

    2012-09-01

    The Stent for Life (SFL) project's main mission is to increase the use of primary percutaneous coronary intervention (PCI) in more than 70% of all acute ST segment elevation myocardial infarction (STEMI) patients. Previous to the SFL project, thrombolysis was the dominant reperfusion strategy since a low percentage of acute STEMI patients had access to primary PCI in our country. In this study, we present the main barriers of access to primary PCI in the centers that were involved with the SFL project. Patients with acute STEMI admitted to the centers that were involved in the SFL project between 2009 and 2011 were included in the analysis. Since the inception of the SFL project, the primary PCI rate has reached over 90% in SFL pilot cities. In the last 5 years, the number of ambulances and emergency stations has increased. Since the collaboration with 112 Emergency Service, a great majority of cases were reached via the emergency medical system. The mean door-to-balloon time for the pilot cities was 54.72±43.66 minutes. After three years of the SFL project, primary PCI has emerged as the preferred reperfusion strategy for patients with STEMI in pilot cities.

  20. Tools for Accurate and Efficient Analysis of Complex Evolutionary Mechanisms in Microbial Genomes. Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Nakhleh, Luay

    2014-03-12

    I proposed to develop computationally efficient tools for accurate detection and reconstruction of microbes' complex evolutionary mechanisms, thus enabling rapid and accurate annotation, analysis and understanding of their genomes. To achieve this goal, I proposed to address three aspects. (1) Mathematical modeling. A major challenge facing the accurate detection of HGT is that of distinguishing between these two events on the one hand and other events that have similar "effects." I proposed to develop a novel mathematical approach for distinguishing among these events. Further, I proposed to develop a set of novel optimization criteria for the evolutionary analysis of microbial genomes in the presence of these complex evolutionary events. (2) Algorithm design. In this aspect of the project, I proposed to develop an array of e cient and accurate algorithms for analyzing microbial genomes based on the formulated optimization criteria. Further, I proposed to test the viability of the criteria and the accuracy of the algorithms in an experimental setting using both synthetic as well as biological data. (3) Software development. I proposed the nal outcome to be a suite of software tools which implements the mathematical models as well as the algorithms developed.

  1. District heating rehabilitation project. Viljandi - Estonia. Final report

    International Nuclear Information System (INIS)

    1998-04-01

    The main objective of the project has been to assist Viljandi Municipality with the rehabilitation of their district heating system, and thereby to support the positive development of the district heating system in Viljandi to a more energy efficient and rational system and to achieve a significantly decrease in the pollution from the production of heat energy in Viljandi. The project has also included technical assistance to Viljandi DH company, in order to make them capable of operation and maintaining of the new substations, and also training of the local operational staff for operation of the complete district heating system. Viljandi is a county and is centrally located in Estonia, which makes Viljandi very suitable as recipient for a demonstration project. One important objective was the projects significantly positive environmental impact in reduction of the generated emissions of CO 2 , NO x and SO 2 , as the project includes installation of more efficient energy systems and supply of heat from the 2 existing district heating plants (both are partly fired with wood chips) instead of heating by very old and worn-out coal fired boilers and inexpedient designed substations with the present operational conditions. (EG)

  2. District heating rehabilitation project. Viljandi - Estonia. Final report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-04-01

    The main objective of the project has been to assist Viljandi Municipality with the rehabilitation of their district heating system, and thereby to support the positive development of the district heating system in Viljandi to a more energy efficient and rational system and to achieve a significantly decrease in the pollution from the production of heat energy in Viljandi. The project has also included technical assistance to Viljandi DH company, in order to make them capable of operation and maintaining of the new substations, and also training of the local operational staff for operation of the complete district heating system. Viljandi is a county and is centrally located in Estonia, which makes Viljandi very suitable as recipient for a demonstration project. One important objective was the projects significantly positive environmental impact in reduction of the generated emissions of CO{sub 2}, NO{sub x} and SO{sub 2}, as the project includes installation of more efficient energy systems and supply of heat from the 2 existing district heating plants (both are partly fired with wood chips) instead of heating by very old and worn-out coal fired boilers and inexpedient designed substations with the present operational conditions. (EG)

  3. Hellsgate Winter Range: Wildlife Mitigation Project. Final Environmental Assessment

    International Nuclear Information System (INIS)

    1995-03-01

    BPA proposes to fund the Hellsgate Winter Range: Wildlife Mitigation Project (Project) in a cooperative effort with the Colville Confederated Tribes and the Bureau of Indian Affairs (BIA). The Project is intended to mitigate for wildlife and wildlife habitat adversely affected by the construction of Grand Coulee and Chief Joseph Dams and their reservoirs. The Project would allow the sponsors to secure land and conduct wildlife habitat improvement and long-term management activities within the boundaries of the Colville Indian Reservation. BPA has prepared an Environmental Assessment (EA) (DOE/EA-0940) evaluating the potential environmental effects of the proposed Project (Alternative B) and No Action (Alternative A). Protection and re-establishment of riparian and upland habitat on the Colville Indian Reservation, under Alternative B, would not have a significant adverse environmental impact because: (1) there would be only limited, mostly short-term adverse impacts on soils, water quality, air quality, vegetation, and wildlife (including no effect on endangered species); and (2) there would be no adverse effect on water quantity, cultural resources, or land use. Based on the analysis in the EA, BPA has determined that the proposed action is not a major Federal action significantly affecting the quality of the human environment, within the meaning of the National Environmental Policy Act (NEPA) of 1969. Therefore, the preparation of an Environmental Impact Statement (EIS) is not required and BPA is issuing this FONSI

  4. Technical Assistance in Evaluating Career Education Projects. Final Report. Volume II: Final Career Education Evaluation Report.

    Science.gov (United States)

    Stenner, A. Jackson; And Others

    This document contains the second of five volumes reporting the activities and results of a career education evaluation project conducted to accomplish the following two objectives: (1) to improve the quality of evaluations by career education projects funded by the United States Office of Career Education (OCE) through the provision of technical…

  5. UMTRA Surface Project management action process document: Final. Revision 2

    International Nuclear Information System (INIS)

    1996-06-01

    Title 1 of the UMTRCA authorized the DOE to undertake remedial actions at these designed sites and associated vicinity properties (VP), which contain uranium mill tailings and other residual radioactive materials (RRM) derived from the processing sites. Title 2 of the UMTRCA addresses uranium mill sites that were licensed at the time the UMTRCA was enacted. Cleanup of these Title 2 sites is the responsibility of the licensees. The cleanup of the Title 1 sites has been split into two separate projects: the Surface Project, which deals with the mill buildings, tailings, and contaminated soils at the sites and VPs; and the Ground Water Project, which is limited to the contaminated ground water at the sites. This management action process (MAP) document discusses the Uranium Mill Tailings Remedial Action (UMTRA) Surface Project. Since its inception through March 1996, the Surface Project (hereinafter called the Project) has cleaned up 16 of the 24 designated processing sites and approximately 5,000 VPs, reducing the risk to human health and the environment posed by the uranium mill tailings. Two of the 24 sites, Belfield and Bowman, North Dakota, will not be remediated at the request of the state, reducing the total number of sites to 22. By the start of FY1998, the remaining 6 processing sites and associated VPs will be cleaned up. The remedial action activities to be funded in FY1998 by the FY1998 budget request are remediation of the remaining Grand Junction, Colorado, VPs; closure of the Cheney disposal cell in Grand Junction, Colorado; and preparation of the completion reports for 4 completed sites

  6. UMTRA Surface Project management action process document: Final. Revision 2

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-06-01

    Title 1 of the UMTRCA authorized the DOE to undertake remedial actions at these designed sites and associated vicinity properties (VP), which contain uranium mill tailings and other residual radioactive materials (RRM) derived from the processing sites. Title 2 of the UMTRCA addresses uranium mill sites that were licensed at the time the UMTRCA was enacted. Cleanup of these Title 2 sites is the responsibility of the licensees. The cleanup of the Title 1 sites has been split into two separate projects: the Surface Project, which deals with the mill buildings, tailings, and contaminated soils at the sites and VPs; and the Ground Water Project, which is limited to the contaminated ground water at the sites. This management action process (MAP) document discusses the Uranium Mill Tailings Remedial Action (UMTRA) Surface Project. Since its inception through March 1996, the Surface Project (hereinafter called the Project) has cleaned up 16 of the 24 designated processing sites and approximately 5,000 VPs, reducing the risk to human health and the environment posed by the uranium mill tailings. Two of the 24 sites, Belfield and Bowman, North Dakota, will not be remediated at the request of the state, reducing the total number of sites to 22. By the start of FY1998, the remaining 6 processing sites and associated VPs will be cleaned up. The remedial action activities to be funded in FY1998 by the FY1998 budget request are remediation of the remaining Grand Junction, Colorado, VPs; closure of the Cheney disposal cell in Grand Junction, Colorado; and preparation of the completion reports for 4 completed sites.

  7. Final report on the LLNL compact torus acceleration project

    International Nuclear Information System (INIS)

    Eddleman, J.; Hammer, J.; Hartman, C.; McLean, H.; Molvik, A.

    1995-01-01

    In this report, we summarize recent work at LLNL on the compact torus (CT) acceleration project. The CT accelerator is a novel technique for projecting plasmas to high velocities and reaching high energy density states. The accelerator exploits magnetic confinement in the CT to stably transport plasma over large distances and to directed kinetic energies large in comparison with the CT internal and magnetic energy. Applications range from heating and fueling magnetic fusion devices, generation of intense pulses of x-rays or neutrons for weapons effects and high energy-density fusion concepts

  8. Basalt Waste Isolation Project exploratory shaft site: Final reclamation report

    International Nuclear Information System (INIS)

    Brandt, C.A.; Rickard, W.H. Jr.

    1990-06-01

    The restoration of areas disturbed by activities of the Basalt Waste Isolation Project (BWIP) constitutes a unique operation at the US Department of Energy's (DOE) Hanford Site, both from the standpoint of restoration objectives and the time frame for accomplishing these objectives. The BWIP reclamation program comprises three separate projects: borehole reclamation, Near Surface Test Facility (NSTF) reclamation, and Exploratory Shaft Facility (ESF) reclamation. The main focus of this report is on determining the success of the revegetation effort 1 year after work was completed. This report also provides a brief overview of the ESF reclamation program. 21 refs., 7 figs., 14 tabs

  9. Final Design Report for the RH LLW Disposal Facility (RDF) Project, Revision 3

    International Nuclear Information System (INIS)

    Austad, Stephanie Lee

    2015-01-01

    The RH LLW Disposal Facility (RDF) Project was designed by AREVA Federal Services (AFS) and the design process was managed by Battelle Energy Alliance (BEA) for the Department of Energy (DOE). The final design report for the RH LLW Disposal Facility Project is a compilation of the documents and deliverables included in the facility final design.

  10. Project Rio Blanco: detonation related activities. Final report

    International Nuclear Information System (INIS)

    1975-01-01

    Project Rio Blanco is described in relation to detonation, its history, execution, and results. Topics discussed include generalized site activities, emplacement well, explosive services and operations, operational safety, environmental protection program, seismic effects and damage claims, and add-on programs. (U.S.)

  11. SmartPark Technology Demonstration Project, Phase II: Final Report

    Science.gov (United States)

    2018-05-01

    The purpose of FMCSA's SmartPark project was to determine the feasibility of a technology for providing truck parking space availability information in real time to truckers on the road. SmartPark consisted of two phases. Phase I was a field operatio...

  12. Final report on the maintenance asset management project : phase I.

    Science.gov (United States)

    2012-07-01

    This project resulted in the development of a proof of concept for a features inventory process to be used by field staff. The resulting concept is adaptable for different asset classes (e.g. culverts, guardrail) and able to leverage existing DOT res...

  13. Project UPSTART. Final Report, October 1, 1983-September 30, 1984.

    Science.gov (United States)

    Frain, Joan

    Project UPSTART, during this fourth year of outreach, offered assistance in replicating its developed Sequenced Neuro-Sensorimotor Program (SNSP) for severely multihandicapped infants, pre-schoolers, young adults and their families. Future replication sites were identified. Programs received outreach assistance in the areas of staff training,…

  14. OECD/NEA Aagesta decontamination project. Phase 1, final report

    International Nuclear Information System (INIS)

    1982-12-01

    The objective of the project is to utilize the four primary loops of the Aagesta reactor to demonstrate decontamination methods for PWR primary systems. The first phase of the project consisted of laboratory scale tests. The methods tested were developed at a) Studsvik Energiteknik AB, Sweden (a soft chemistry). b) Kraftwerk Union AG, Federal Republic of Germany, (two chemistries, one soft and one hard). c) Swiss Federal Institute of Reactor Research (two chemistries, one soft and one hard). d) Berkeley Nuclear Laboratories, United Kingdom, (a soft chemistry). The test programme consisted of decontamination tests on steam generator tubing and other active material from Aagesta and a number of operating reactors as well as material compatibility tests on standardized samples of a representative selection of modern PWR primary system materials. Six countries have participated in Phase I of the project - the four countries named above as well as the United States of America and Italy. Studsvik Energiteknik AB was appointed Project leader. The results show that all six processes in general met the acceptance criteria both regarding decontamination and corrosion. The decontamination results with the hard chemistries were rather uneven. (Author)

  15. Urban Options Solar Greenhouse Demonstration Project. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Cipparone, L.

    1980-10-15

    The following are included: the design process, construction, thermal performance, horticulture, educational activities, and future plans. Included in appendices are: greenhouse blueprints, insulating curtain details, workshop schedules, sample data forms, summary of performance calculations on the Urban Options Solar Greenhouse, data on vegetable production, publications, news articles on th Solar Greenhouse Project, and the financial statement. (MHR)

  16. Healy Clean Coal Project, Healy, Alaska final Environmental Monitoring Plan

    Energy Technology Data Exchange (ETDEWEB)

    1994-06-14

    This Environmental Monitoring Plan (EMP) provides the mechanism to evaluate the integrated coal combustion/emission control system being demonstrated by the Healy Clean Coal Project (HCCP) as part-of the third solicitation of the US Department of Energy (DOE) Clean Coal Technology Demonstration Program (CCT-III). The EMP monitoring is intended to satisfy two objectives: (1) to develop the information base necessary for identification, assessment, and mitigation of potential environmental problems arising from replication of the technology and (2) to identify and quantify project-specific and site-specific environmental impacts predicted in the National Environmental Policy Act (NEPA) documents (Environmental Impact Statement and Record of Decision). The EMP contains a description of the background and history of development of the project technologies and defines the processes that will take place in the combustion and spray dryer absorber systems, including the formation of flash-calcined material (FCM) and its use in sulfur dioxide (SO{sub 2}) removal from the flue gases. It also contains a description of the existing environmental resources of the project area. The EMP includes two types of environmental monitoring that are to be used to demonstrate the technologies of the HCCP: compliance monitoring and supplemental monitoring. Compliance monitoring activities include air emissions, wastewater effluents, and visibility. Monitoring of these resources provide the data necessary to demonstrate that the power plant can operate under the required state and federal statutes, regulations, and permit requirements.

  17. Learning and Optimization of Cognitive Capabilities. Final Project Report.

    Science.gov (United States)

    Lumsdaine, A.A.; And Others

    The work of a three-year series of experimental studies of human cognition is summarized in this report. Proglem solving and learning in man-machine interaction was investigated, as well as relevant variables and processes. The work included four separate projects: (1) computer-aided problem solving, (2) computer-aided instruction techniques, (3)…

  18. Final Technical Report for Terabit-scale hybrid networking project.

    Energy Technology Data Exchange (ETDEWEB)

    Veeraraghavan, Malathi [Univ. of Virginia, Charlottesville, VA (United States)

    2015-12-12

    This report describes our accomplishments and activities for the project titled Terabit-Scale Hybrid Networking. The key accomplishment is that we developed, tested and deployed an Alpha Flow Characterization System (AFCS) in ESnet. It is being run in production mode since Sept. 2015. Also, a new QoS class was added to ESnet5 to support alpha flows.

  19. Hospitality Occupational Skills Training Cooperative. Project HOST Final Report.

    Science.gov (United States)

    Northwest Educational Cooperative, Des Plaines, IL.

    Project HOST (Hospitality Occupational Skills Training) provided vocational training and employment opportunities in the hotel industry to disadvantaged adult minority populations in Chicago. It demonstrated a model for successful cooperation between the business sector and a public vocational education agency and developed and piloted a…

  20. Missouri Soybean Association Biodiesel Demonstration Project: Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Ludwig, Dale [Missouri Soybean Association, Jefferson City, MO (United States); Hamilton, Jill [Sustainable Energy Strategies, Inc., Fairfax, VA (United States)

    2011-10-27

    The Missouri Soybean Association (MSA) and the National Biodiesel Board (NBB) partnered together to implement the MSA Biodiesel Demonstration project under a United States Department of Energy (DOE) grant. The goal of this project was to provide decision makers and fleet managers with information that could lead to the increased use of domestically produced renewable fuels and could reduce the harmful impacts of school bus diesel exhaust on children. This project was initiated in September 2004 and completed in April 2011. The project carried out a broad range of activities organized under four areas: 1. Petroleum and related industry education program for fuel suppliers; 2. Fleet evaluation program using B20 with a Missouri school district; 3. Outreach and awareness campaign for school district fleet managers; and 4. Support of ongoing B20 Fleet Evaluation Team (FET) data collection efforts with existing school districts. Technical support to the biodiesel industry was also provided through NBB’s Troubleshooting Hotline. The hotline program was established in 2008 to troubleshoot fuel quality issues and help facilitate smooth implementation of the RFS and is described in greater detail under Milestone A.1 - Promote Instruction and Guidance on Best Practices. As a result of this project’s efforts, MSA and NBB were able to successfully reach out to and support a broad spectrum of biodiesel users in Missouri and New England. The MSA Biodiesel Demonstration was funded through a FY2004 Renewable Energy Resources Congressional earmark. The initial focus of this project was to test and evaluate biodiesel blends coupled with diesel oxidation catalysts as an emissions reduction technology for school bus fleets in the United States. The project was designed to verify emissions reductions using Environmental Protection Agency (EPA) protocols, then document – with school bus fleet experience – the viability of utilizing B20 blends. The fleet experience was expected to

  1. Final Technical Report - Modernization of the Boulder Canyon Hydroelectric Project

    Energy Technology Data Exchange (ETDEWEB)

    Taddeucci, Joe [Dept. of Public Works, Boulder, CO (United States). Utilities Division

    2013-03-29

    The Boulder Canyon Hydroelectric Project (BCH) was purchased by the City of Boulder, CO (the city) in 2001. Project facilities were originally constructed in 1910 and upgraded in the 1930s and 1940s. By 2009, the two 10 MW turbine/generators had reached or were nearing the end of their useful lives. One generator had grounded out and was beyond repair, reducing plant capacity to 10 MW. The remaining 10 MW unit was expected to fail at any time. When the BCH power plant was originally constructed, a sizeable water supply was available for the sole purpose of hydroelectric power generation. Between 1950 and 2001, that water supply had gradually been converted to municipal water supply by the city. By 2001, the water available for hydroelectric power generation at BCH could not support even one 10 MW unit. Boulder lacked the financial resources to modernize the facilities, and Boulder anticipated that when the single, operational historical unit failed, the project would cease operation. In 2009, the City of Boulder applied for and received a U.S. Department of Energy (DOE) grant for $1.18 million toward a total estimated project cost of $5.155 million to modernize BCH. The federal funding allowed Boulder to move forward with plant modifications that would ensure BCH would continue operation. Federal funding was made available through the American Recovery and Reinvestment Act (ARRA) of 2009. Boulder determined that a single 5 MW turbine/generator would be the most appropriate capacity, given the reduced water supply to the plant. Average annual BCH generation with the old 10 MW unit had been about 8,500 MW-hr, whereas annual generation with a new, efficient turbine could average 11,000 to 12,000 MW-hr. The incremental change in annual generation represents a 30% increase in generation over pre-project conditions. The old turbine/generator was a single nozzle Pelton turbine with a 5-to-1 flow turndown and a maximum turbine/generator efficiency of 82%. The new unit is a

  2. Decontamination and dismantlement of the JANUS Reactor at Argonne National Laboratory-East. Project final report

    International Nuclear Information System (INIS)

    Fellhauer, C.R.; Clark, F.R.

    1997-10-01

    The decontamination and dismantlement of the JANUS Reactor at Argonne National Laboratory-East (ANL-E) was completed in October 1997. Descriptions and evaluations of the activities performed and analyses of the results obtained during the JANUS D and D Project are provided in this Final Report. The following information is included: objective of the JANUS D and D Project; history of the JANUS Reactor facility; description of the ANL-E site and the JANUS Reactor facility; overview of the D and D activities performed; description of the project planning and engineering; description of the D and D operations; summary of the final status of the JANUS Reactor facility based upon the final survey results; description of the health and safety aspects of the project, including personnel exposure and OSHA reporting; summary of the waste minimization techniques utilized and total waste generated by the project; and summary of the final cost and schedule for the JANUS D and D Project

  3. The ENCOAL Mild Coal Gasification Project, A DOE Assessment; FINAL

    International Nuclear Information System (INIS)

    National Energy Technology Laboratory

    2002-01-01

    This report is a post-project assessment of the ENCOAL(reg s ign) Mild Coal Gasification Project, which was selected under Round III of the U.S. Department of Energy (DOE) Clean Coal Technology (CCT) Demonstration Program. The CCT Demonstration Program is a government and industry cofunded technology development effort to demonstrate a new generation of innovative coal utilization processes in a series of commercial-scale facilities. The ENCOAL(reg s ign) Corporation, a wholly-owned subsidiary of Bluegrass Coal Development Company (formerly SMC Mining Company), which is a subsidiary of Ziegler Coal Holding Company, submitted an application to the DOE in August 1989, soliciting joint funding of the project in the third round of the CCT Program. The project was selected by DOE in December 1989, and the Cooperative Agreement (CA) was approved in September 1990. Construction, commissioning, and start-up of the ENCOAL(reg s ign) mild coal gasification facility was completed in June 1992. In October 1994, ENCOAL(reg s ign) was granted a two-year extension of the CA with the DOE, that carried through to September 17, 1996. ENCOAL(reg s ign) was then granted a six-month, no-cost extension through March 17, 1997. Overall, DOE provided 50 percent of the total project cost of$90,664,000. ENCOAL(reg s ign) operated the 1,000-ton-per-day mild gasification demonstration plant at Triton Coal Company's Buckskin Mine near Gillette, Wyoming, for over four years. The process, using Liquids From Coal (LFC(trademark)) technology originally developed by SMC Mining Company and SGI International, utilizes low-sulfur Powder River Basin (PRB) coal to produce two new fuels, Process-Derived Fuel (PDF(trademark)) and Coal-Derived Liquids (CDL(trademark)). The products, as alternative fuel sources, are capable of significantly lowering current sulfur emissions at industrial and utility boiler sites throughout the nation thus reducing pollutants causing acid rain. In support of this overall

  4. THz transceiver characterization : LDRD project 139363 final report.

    Energy Technology Data Exchange (ETDEWEB)

    Nordquist, Christopher Daniel; Wanke, Michael Clement; Cich, Michael Joseph; Reno, John Louis; Fuller, Charles T.; Wendt, Joel Robert; Lee, Mark; Grine, Albert D.

    2009-09-01

    LDRD Project 139363 supported experiments to quantify the performance characteristics of monolithically integrated Schottky diode + quantum cascade laser (QCL) heterodyne mixers at terahertz (THz) frequencies. These integrated mixers are the first all-semiconductor THz devices to successfully incorporate a rectifying diode directly into the optical waveguide of a QCL, obviating the conventional optical coupling between a THz local oscillator and rectifier in a heterodyne mixer system. This integrated mixer was shown to function as a true heterodyne receiver of an externally received THz signal, a breakthrough which may lead to more widespread acceptance of this new THz technology paradigm. In addition, questions about QCL mode shifting in response to temperature, bias, and external feedback, and to what extent internal frequency locking can improve stability have been answered under this project.

  5. Final project report: High energy rotor development, test and evaluation

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-09-01

    Under the auspices of the {open_quotes}Government/Industry Wind Technology Applications Project{close_quotes} [{open_quotes}Letter of Interest{close_quotes} (LOI) Number RC-1-11101], Flo Wind Corp. has successfully developed, tested, and delivered a high-energy rotor upgrade candidate for their 19-meter Vertical Axis Wind Turbine. The project included the demonstration of the innovative extended height-to-diameter ratio concept, the development of a continuous span single-piece composite blade, the demonstration of a continuous blade manufacturing technique, the utilization of the Sandia National Laboratories developed SNLA 2150 natural laminar flow airfoil and the reuse of existing wind turbine and wind power plant infrastructure.

  6. BPA/PGE transmission support project: Final environmental assessment

    International Nuclear Information System (INIS)

    1996-12-01

    This Mitigation Action Plan describes the mitigation measures identified in the BPA/PGE Transmission Support Project Environmental Assessment. These measures commit to actions that will reduce the environmental impacts that could occur by constructing, operating and maintaining the transmission line and related facilities. They have been developed in coordination with environmental specialists, design and construction engineers and maintenance personnel. The measures will be written into the construction specifications for the project, which is expected to be constructed by contract personnel. Unless noted in the plan, the construction inspector or the line foreman would be responsible for carrying out the mitigation; environmental staff would also monitor the area for mitigation effectiveness. The right-of-way would be cleared in 1997 or 1998, and construction would begin in the spring of 1998 and be completed later that fall

  7. Project GICC-Rhone Final report of part I

    International Nuclear Information System (INIS)

    2002-12-01

    The project aims to give an evaluation of the impacts on the french Rhone basin, of the climatic change resulting of a double of the CO 2 content in the atmosphere (possible in 2050). This report gives an evaluation of the researches progress. It describes the topic of the part I, the hydrological simulations realized and the analysis of the hydrological impacts. It provides also recommendations for the part II. The following topics are presented: the objectives of the project; the data and the atmospheric scenari construction methods on the Rhone basin under the climatic change; the used hydrological models; the results analysis in terms of hydrogeological impacts; the limits of the approach; and a bibliography. (A.L.B.)

  8. Human genome education model project. Ethical, legal, and social implications of the human genome project: Education of interdisciplinary professionals

    Energy Technology Data Exchange (ETDEWEB)

    Weiss, J.O. [Alliance of Genetic Support Groups, Chevy Chase, MD (United States); Lapham, E.V. [Georgetown Univ., Washington, DC (United States). Child Development Center

    1996-12-31

    This meeting was held June 10, 1996 at Georgetown University. The purpose of this meeting was to provide a multidisciplinary forum for exchange of state-of-the-art information on the human genome education model. Topics of discussion include the following: psychosocial issues; ethical issues for professionals; legislative issues and update; and education issues.

  9. Navajo transmission project. Final Environmental Impact Statement (FEIS)

    International Nuclear Information System (INIS)

    1997-08-01

    Dine Power Authority, a Navajo Nation enterprise, proposes to construct a 500 kilovolt transmission line planned to deliver electrical power from the Shiprock Substation in northwestern New Mexico to the Marketplace Substation in southern Nevada. The line would relieve constraints on transmission of electricity west from the Four Corners area; improve operational flexibility and reliability of the overall system; and allow increased economical transfers, sales, and purchases in the Rocky Mountains/Four Corners/Desert Southwest region. Also, the project allows an opportunity for the Navajo Nation to participate in the electrical utility industry and promote economic development to benefit the people of the Navajo Nation. Six alternatives were considered and include (1) energy conservation and electric load management, (2) new generation facilities, (3) use of existing transmission systems, (4) alternative transmission technologies, (5) no action, and (6) the proposed action. For the proposed action, the following alternative routes and ancillary facility locations are addressed in the EIS: four alternative routes and five substations in the eastern portion of the project area; and six alternative routes, three substation sites, and a microwave communication facility in the western portion of the project area. The existing condition of the environmental resources in the project area is described, and potential impacts on those resources as a result of the proposed action are addressed. The impacts of the proposed action would be caused mainly by access roads, tower sites, and other associated facilities on soils, vegetation, wildlife, and cultural and paleontological resources; and the impact of the transmission line's presence on visual resources and land uses. Public comments on the draft EIS are addressed in this FEIS

  10. The project for an energy-enriched curriculum: Final report

    Energy Technology Data Exchange (ETDEWEB)

    1984-01-01

    The Project for an Energy-Enriched Curriculum (PEEC) reported was a long-running effort at infusing energy/environment/economics (E/E/E) themes into the K-12 curriculum. While it was conducted as a single integrated effort by the National Science Teachers Association (NSTA), it is supported by a series of contracts and grants, during the period 1976 to 1984, from the Energy Research and Development Administration (ERDA) and the US Department of Energy (DOE).

  11. Domain Specific Language Support for Exascale. Final Project Report

    Energy Technology Data Exchange (ETDEWEB)

    Baden, Scott [Univ. of California, San Diego, CA (United States)

    2017-07-11

    The project developed a domain specific translator enable legacy MPI source code to tolerate communication delays, which are increasing over time due to technological factors. The translator performs source-to-source translation that incorporates semantic information into the translation process. The output of the translator is a C program runs as a data driven program, and uses an existing run time to overlap communication automatically

  12. NNWSI project information management system concepts evaluation report. Final report

    International Nuclear Information System (INIS)

    1986-08-01

    This report is intended as a first step in developing detailed information management system specifications for the Nevada Nuclear Waste Storage Investigations (NNWSI) Project. The current state of information management at the NNWSI Project level is investigated and an information management system (IMS) is proposed. The IMS as it relates to aspects of Project and records management is discussed. Information management concepts and prospective IMS system components are investigated. Concepts and system components include: indexing, searching, retrieval, data base management system technology, computers, storage media, computer-assisted retrieval (CAR) of microfilm, electronic imaging-based systems, optical character recognition, and communications. Performance criteria and desirable system attributes applicable to the IMS are discussed. Six conceptual system approaches capable of satisfying the performance criteria are defined. System approaches include: fully centralized microfilm system based on CAR retrieval (Approach 1), partially distributed microfilm system based on CAR retrieval (Approach 2), fully distributed microfilm system based on CAR retrieval (Approach 3), fully centralized optical disk system based on electronic image and full-text retrieval (Approach 4), partially distributed optical system based on electron image and full-text retrieval (Approach 5), and fully distributed optical disk system based on electronic image and full-text retrieval (Approach 6). Technical and cost considerations associated with the six conceptual approaches are evaluated. Technical evaluation results indicate Approach 4 is the best conceptual approach, and cost evaluation results show no significant differences among approaches. On the basis of the evaluation, Approach 4 is recommended

  13. Willow Creek Wildlife Mitigation Project. Final Environmental Assessment.

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-04-01

    Today`s notice announces BPA`s proposal to fund land acquisition or acquisition of a conservation easement and a wildlife management plan to protect and enhance wildlife habitat at the Willow Creek Natural Area in Eugene, Oregon. This action would provide partial mitigation for wildlife and wildlife habitat lost by the development of Federal hydroelectric projects in the Willamette River Basin. The project is consistent with BPA`s obligations under provisions of the Pacific Northwest Electric Power Planning and Conservation Act of 1980 as outlined by the Northwest Power Planning Council`s 1994 Columbia River Basin Fish and Wildlife Program. BPA has prepared an environmental assessment (DOE/EA-1023) evaluating the proposed project. Based on the analysis in the EA, BPA has determined that the proposed action is not a major Federal action significantly affecting the quality of the human environment, within the meaning of the National Environmental Policy Act (NEPA) of 1969. Therefore, the preparation of an environmental impact statement (EIS) is not required and BPA is issuing this FONSI.

  14. Willow Creek Wildlife Mitigation Project. Final environmental assessment

    International Nuclear Information System (INIS)

    1995-04-01

    Today's notice announces BPA's proposal to fund land acquisition or acquisition of a conservation easement and a wildlife management plan to protect and enhance wildlife habitat at the Willow Creek Natural Area in Eugene, Oregon. This action would provide partial mitigation for wildlife and wildlife habitat lost by the development of Federal hydroelectric projects in the Willamette River Basin. The project is consistent with BPA's obligations under provisions of the Pacific Northwest Electric Power Planning and Conservation Act of 1980 as outlined by the Northwest Power Planning Council's 1994 Columbia River Basin Fish and Wildlife Program. BPA has prepared an environmental assessment (DOE/EA-1023) evaluating the proposed project. Based on the analysis in the EA, BPA has determined that the proposed action is not a major Federal action significantly affecting the quality of the human environment, within the meaning of the National Environmental Policy Act (NEPA) of 1969. Therefore, the preparation of an environmental impact statement (EIS) is not required and BPA is issuing this FONSI

  15. Final Scientifc Report - Hydrogen Education State Partnership Project

    Energy Technology Data Exchange (ETDEWEB)

    Leon, Warren

    2012-02-03

    Under the leadership of the Department of Energy Hydrogen and Fuel Cells program, Clean Energy States Alliance (CESA) educated and worked with state leaders to encourage wider deployment of fuel cell and hydrogen technologies. Through outreach to state policymakers, legislative leaders, clean energy funds, energy agencies, and public utility commissions, CESA worked to accomplish the following objectives of this project: 1. Provide information and technical assistance to state policy leaders and state renewable energy programs in the development of effective hydrogen fuel cell programs. 2. Identify and foster hydrogen program best practices. 3. Identify and promote strategic opportunities for states and the Department of Energy (DOE) to advance hydrogen technology deployment through partnerships, collaboration, and targeted activities. Over the three years of this project, CESA, with our partner National Conference of State Legislatures (NCSL), was able to provide credible information on fuel cell policies, finance, and technical assistance to hundreds of state officials and other stakeholders. CESA worked with its membership network to effectively educate state clean energy policymakers, program managers, and decision makers about fuel cell and hydrogen technologies and the efforts by states to advance those technologies. With the assistance of NCSL, CESA gained access to an effective forum for outreach and communication with state legislators from all 50 states on hydrogen issues and policies. This project worked to educate policymakers and stakeholders with the potential to develop and deploy stationary and portable fuel cell technologies.

  16. Integrated System Health Management (ISHM) Technology Demonstration Project Final Report

    Science.gov (United States)

    Mackey, Ryan; Iverson, David; Pisanich, Greg; Toberman, Mike; Hicks, Ken

    2006-01-01

    Integrated System Health Management (ISHM) is an essential capability that will be required to enable upcoming explorations mission systems such as the Crew Exploration Vehicle (CEV) and Crew Launch Vehicle (CLV), as well as NASA aeronautics missions. However, the lack of flight experience and available test platforms have held back the infusion by NASA Ames Research Center (ARC) and the Jet Propulsion Laboratory (JPL) of ISHM technologies into future space and aeronautical missions. To address this problem, a pioneer project was conceived to use a high-performance aircraft as a low-cost proxy to develop, mature, and verify the effectiveness of candidate ISHM technologies. Given the similarities between spacecraft and aircraft, an F/A-18 currently stationed at Dryden Flight Research Center (DFRC) was chosen as a suitable host platform for the test bed. This report describes how the test bed was conceived, how the technologies were integrated on to the aircraft, and how these technologies were matured during the project. It also describes the lessons learned during the project and a forward path for continued work.

  17. Canister Cleaning System Final Design Report - Project A.2.A

    International Nuclear Information System (INIS)

    FARWICK, C.C.

    2000-01-01

    Approximately 2,300 metric tons Spent Nuclear Fuel (SNF) are currently stored within two water filled pools, the 105 K East (KE) fuel storage basin and the 105 K West (KW) fuel storage basin, at the U.S. Department of Energy, Richland Operations Office (RL). The SNF Project is responsible for operation of the K Basins and for the materials within them. A subproject to the SNF Project is the Debris Removal Subproject, which is responsible for removal of empty canisters and lids from the basins. The Canister Cleaning System (CCS) is part of the Debris Removal Project. The CCS will be installed in the KW Basin and operated during the fuel removal activity. The KW Basin has approximately 3600 canisters that require removal from the basin. The CCS is being designed to ''clean'' empty fuel canisters and lids and package them for disposal to the Environmental Restoration Disposal Facility complex. The system will interface with the KW Basin and be located in the Dummy Elevator Pit

  18. Final Hanford Site Transuranic (TRU) Waste Characterization QA Project Plan

    International Nuclear Information System (INIS)

    GREAGER, T.M.

    2000-01-01

    The Quality Assurance Project Plan (QAPjP) has been prepared for waste characterization activities to be conducted by the Transuranic (TRU) Project at the Hanford Site to meet requirements set forth in the Waste Isolation Pilot Plan (WIPP) Hazardous Waste Facility Permit, 4890139088-TSDF, Attachment B, including Attachments B1 through B6 (WAP) (DOE, 1999a). The QAPjP describes the waste characterization requirements and includes test methods, details of planned waste sampling and analysis, and a description of the waste characterization and verification process. In addition, the QAPjP includes a description of the quality assurance/quality control (QA/QC) requirements for the waste characterization program. Before TRU waste is shipped to the WIPP site by the TRU Project, all applicable requirements of the QAPjP shall be implemented. Additional requirements necessary for transportation to waste disposal at WIPP can be found in the ''Quality Assurance Program Document'' (DOE 1999b) and HNF-2600, ''Hanford Site Transuranic Waste Certification Plan.'' TRU mixed waste contains both TRU radioactive and hazardous components, as defined in the WLPP-WAP. The waste is designated and separately packaged as either contact-handled (CH) or remote-handled (RH), based on the radiological dose rate at the surface of the waste container. RH TRU wastes are not currently shipped to the WIPP facility

  19. Draft project management update to the Iowa DOT Project Development Manual : final report.

    Science.gov (United States)

    2016-08-01

    This work supported drafting project management guidance for the Iowa Department of Transportation (DOT). The goal is to : incorporate a greater focus on project management in their project development process. : A technical advisory committee (TAC) ...

  20. 2009 ESMD Space Grant Faculty Project Final Report

    Science.gov (United States)

    Murphy, Gloria; Ghanashyam, Joshi; Guo, Jiang; Conrad, James; Bandyopadhyay, Alak; Cross, William

    2009-01-01

    The Constellation Program is the medium by which we will maintain a presence in low Earth orbit, return to the moon for further exploration and develop procedures for Mars exploration. The foundation for its presence and success is built by the many individuals that have given of their time, talent and even lives to help propel the mission and objectives of NASA. The Exploration Systems Mission Directorate (ESMD) Faculty Fellows Program is a direct contributor to the success of directorate and Constellation Program objectives. It is through programs such as the ESMD Space Grant program that students are inspired and challenged to achieve the technological heights that will propel us to meet the goals and objectives of ESMD and the Constellation Program. It is through ESMD Space Grant programs that future NASA scientists, engineers, and mathematicians begin to dream of taking America to newer heights of space exploration. The ESMD Space Grant program is to be commended for taking the initiative to develop and implement programs that help solidify the mission of NASA. With the concerted efforts of the Kennedy Space Center educational staff, the 2009 ESMD Space Grant Summer Faculty Fellows Program allowed faculty to become more involved with NASA personnel relating to exploration topics for the senior design projects. The 2009 Project was specifically directed towards NASA's Strategic Educational Outcome 1. In-situ placement of Faculty Fellows at the NASA field Centers was essential; this allowed personal interactions with NASA scientists and engineers. In particular, this was critical to better understanding the NASA problems and begin developing a senior design effort to solve the problems. The Faculty Fellows are pleased that the ESMD Space Grant program is taking interest in developing the Senior Design courses at the university level. These courses are needed to help develop the NASA engineers and scientists of the very near future. It has been a pleasure to be

  1. OECD-IAEA Paks Fuel Project. Final Report

    International Nuclear Information System (INIS)

    2010-05-01

    It is important for nuclear power plant designers, operators and regulators to effectively use lessons learned from events occurring at nuclear power plants since, in general, it is impossible to reproduce the event using experimental facilities. In particular, evaluation of the event using accident analysis codes is expected to contribute to improving understanding of phenomena during the events and to facilitate the validation of computer codes through simulation analyses. The information presented in this publication will be of use in future revisions of safety guides on accident analysis. During a fuel crud removal operation on the Paks-2 unit of the Paks nuclear power plant, Hungary on 10 April 2003, several fuel assemblies were severely damaged. The assemblies were being cleaned in a special tank under deep water in a service pit connected to the spent fuel storage pool. The first sign of fuel failures was the detection of some fission gases released from the cleaning tank. Later, visual inspection revealed that most of the 30 fuel assemblies suffered heavy oxidation and fragmentation. The first evaluation of the event showed that the severe fuel damage had been caused by inadequate cooling. The Paks-2 event was discussed in various committees of the OECD Nuclear Energy Agency (OECD/NEA) and of the International Atomic Energy Agency (IAEA). Recommendations were made to undertake actions to improve the understanding of the incident sequence and of the consequence this had on the fuel. It was considered that the Paks-2 event may constitute a useful case for a comparative exercise on safety codes, in particular for models devised to predict fuel damage and potential releases under abnormal cooling conditions and the analyses of the Paks-2 event may provide information which is relevant for in-reactor and spent fuel storage safety evaluations. The OECD-IAEA Paks Fuel Project was established in 2005 as a joint project between the IAEA and the OECD/NEA. The IAEA

  2. Enabling a community to dissect an organism: overview of the Neurospora functional genomics project.

    Science.gov (United States)

    Dunlap, Jay C; Borkovich, Katherine A; Henn, Matthew R; Turner, Gloria E; Sachs, Matthew S; Glass, N Louise; McCluskey, Kevin; Plamann, Michael; Galagan, James E; Birren, Bruce W; Weiss, Richard L; Townsend, Jeffrey P; Loros, Jennifer J; Nelson, Mary Anne; Lambreghts, Randy; Colot, Hildur V; Park, Gyungsoon; Collopy, Patrick; Ringelberg, Carol; Crew, Christopher; Litvinkova, Liubov; DeCaprio, Dave; Hood, Heather M; Curilla, Susan; Shi, Mi; Crawford, Matthew; Koerhsen, Michael; Montgomery, Phil; Larson, Lisa; Pearson, Matthew; Kasuga, Takao; Tian, Chaoguang; Baştürkmen, Meray; Altamirano, Lorena; Xu, Junhuan

    2007-01-01

    A consortium of investigators is engaged in a functional genomics project centered on the filamentous fungus Neurospora, with an eye to opening up the functional genomic analysis of all the filamentous fungi. The overall goal of the four interdependent projects in this effort is to accomplish functional genomics, annotation, and expression analyses of Neurospora crassa, a filamentous fungus that is an established model for the assemblage of over 250,000 species of non yeast fungi. Building from the completely sequenced 43-Mb Neurospora genome, Project 1 is pursuing the systematic disruption of genes through targeted gene replacements, phenotypic analysis of mutant strains, and their distribution to the scientific community at large. Project 2, through a primary focus in Annotation and Bioinformatics, has developed a platform for electronically capturing community feedback and data about the existing annotation, while building and maintaining a database to capture and display information about phenotypes. Oligonucleotide-based microarrays created in Project 3 are being used to collect baseline expression data for the nearly 11,000 distinguishable transcripts in Neurospora under various conditions of growth and development, and eventually to begin to analyze the global effects of loss of novel genes in strains created by Project 1. cDNA libraries generated in Project 4 document the overall complexity of expressed sequences in Neurospora, including alternative splicing alternative promoters and antisense transcripts. In addition, these studies have driven the assembly of an SNP map presently populated by nearly 300 markers that will greatly accelerate the positional cloning of genes.

  3. 76 FR 67178 - Wells Hydroelectric Project; Notice of Availability of the Final Environmental Impact Statement...

    Science.gov (United States)

    2011-10-31

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Project No. 2149-152] Wells Hydroelectric Project; Notice of Availability of the Final Environmental Impact Statement for the Wells... application for license for the Wells Hydroelectric Project (FERC No. 2149), located on the Columbia River in...

  4. Staff Helping Attain Relevant Education (Project SHARE): Final Evaluation Report, 1992-93. OREA Report.

    Science.gov (United States)

    Ranadive, Jyoti

    Project SHARE (Staff Helping Attain Relevant Education), a project funded by Title VII of the Elementary and Secondary Education Act, was in its third and final year of operation in 1992-93, in eight primary schools in the Bronx, Brooklyn, and Manhattan (New York). The project served 141 limited English proficient students from low-income families…

  5. Competence development organizations in project management on the basis of genomic model methodologies

    OpenAIRE

    Бушуев, Сергей Дмитриевич; Рогозина, Виктория Борисовна; Ярошенко, Юрий Федерович

    2013-01-01

    The matrix technology for identification of organisational competencies in project management is presented in the article. Matrix elements are the components of organizational competence in the field of project management and project management methodology represented in the structure of the genome. The matrix model of competence in the framework of the adopted methodologies and scanning method for identifying organizational competences formalised. Proposed methods for building effective proj...

  6. Space Processing Applications Rocket project, SPAR 1. Final report

    International Nuclear Information System (INIS)

    Reeves, F.; Chassay, R.

    1976-12-01

    The experiment objectives, design/operational concepts, and final results of each of nine scientific experiments conducted during the first Space Processing Applications Rocket (SPAR) flight are summarized. The nine individual SPAR experiments, covering a wide and varied range of scientific materials processing objectives, were entitled: solidification of Pb-Sb eutectic, feasibility of producing closed-cell metal foams, characterization of rocket vibration environment by measurement of mixing of two liquids, uniform dispersions of crystallization processing, direct observation of solidification as a function of gravity levels, casting thoria dispersion-strengthened interfaces, contained polycrystalline solidification, and preparation of a special alloy for manufacturing of magnetic hard superconductor under zero-g environment

  7. Space Processing Applications rocket project SPAR III. Final report

    International Nuclear Information System (INIS)

    Reeves, F.

    1978-01-01

    This document presents the engineering report and science payload III test report and summarizes the experiment objectives, design/operational concepts, and final results of each of five scientific experiments conducted during the third Space Processing Applications Rocket (SPAR) flight flown by NASA in December 1976. The five individual SPAR experiments, covering a wide and varied range of scientific materials processing objectives, were entitled: Liquid Mixing, Interaction of Bubbles with Solidification Interfaces, Epitaxial Growth of Single Crystal Film, Containerless Processing of Beryllium, and Contact and Coalescence of Viscous Bodies

  8. Final report for SNL/NM environmental drilling project

    International Nuclear Information System (INIS)

    Wemple, R.P.; Meyer, R.D.; Staller, G.E.; Layne, R.R.

    1994-11-01

    Concern for the environment and cost reduction are driving forces for a broad effort in government and the private sector to develop new, more cost-effective technologies for characterizing, monitoring and remediating environmental sites. Secondary goals of the characterization, monitoring and remediation (CMR) activity are: minimize secondary waste generation, minimize site impact, protect water tables, and develop methods/strategies to apply new technologies. The Sandia National Laboratories (SNL) project in directional boring for CMR of waste sites with enhanced machinery from the underground utility installation industry was initiated in 1990. The project has tested a variety of prototype machinery and hardware built by the industrial partner, Charles Machine Works (CMW), and SNL at several sites (Savannah River Site (SRS), Hanford, SNL, Kirtland AFB (KAFB), CMW), successfully installed usable horizontal environmental test wells at SRS and SNL/KAFB, and functioned as a clearing house for information regarding application of existing commercial machinery to a variety of governmental and commercial sites. The project has continued to test and develop machinery in FY 94. The original goal of cost-effectiveness is being met through innovation, adaptation, and application of fundamental concepts. Secondary goals are being met via a basic philosophy of open-quotes cut/thrust and compact cuttings without adding large quantities of fluidclose quotes to an environmental problem site. This technology will be very cost-effective where applicable. Technology transfer and commercialization by CMW is ongoing and will continue into FY 95. Technology transfer to the private sector is ongoing and reflected in increasing machinery sales to environmental contractors. Education of regulatory agencies resulting in restructuring of appropriate regulatory standards for specification of the horizontal drilling techniques continues to be a long-range goal

  9. Final report for SNL/NM environmental drilling project

    Energy Technology Data Exchange (ETDEWEB)

    Wemple, R.P.; Meyer, R.D.; Staller, G.E. [Sandia National Labs., Albuquerque, NM (United States); Layne, R.R. [Charles Machine Works, Inc., Perry, OK (United States)

    1994-11-01

    Concern for the environment and cost reduction are driving forces for a broad effort in government and the private sector to develop new, more cost-effective technologies for characterizing, monitoring and remediating environmental sites. Secondary goals of the characterization, monitoring and remediation (CMR) activity are: minimize secondary waste generation, minimize site impact, protect water tables, and develop methods/strategies to apply new technologies. The Sandia National Laboratories (SNL) project in directional boring for CMR of waste sites with enhanced machinery from the underground utility installation industry was initiated in 1990. The project has tested a variety of prototype machinery and hardware built by the industrial partner, Charles Machine Works (CMW), and SNL at several sites (Savannah River Site (SRS), Hanford, SNL, Kirtland AFB (KAFB), CMW), successfully installed usable horizontal environmental test wells at SRS and SNL/KAFB, and functioned as a clearing house for information regarding application of existing commercial machinery to a variety of governmental and commercial sites. The project has continued to test and develop machinery in FY 94. The original goal of cost-effectiveness is being met through innovation, adaptation, and application of fundamental concepts. Secondary goals are being met via a basic philosophy of {open_quotes}cut/thrust and compact cuttings without adding large quantities of fluid{close_quotes} to an environmental problem site. This technology will be very cost-effective where applicable. Technology transfer and commercialization by CMW is ongoing and will continue into FY 95. Technology transfer to the private sector is ongoing and reflected in increasing machinery sales to environmental contractors. Education of regulatory agencies resulting in restructuring of appropriate regulatory standards for specification of the horizontal drilling techniques continues to be a long-range goal.

  10. Messiah College Biodiesel Fuel Generation Project Final Technical Report

    Energy Technology Data Exchange (ETDEWEB)

    Zummo, Michael M; Munson, J; Derr, A; Zemple, T; Bray, S; Studer, B; Miller, J; Beckler, J; Hahn, A; Martinez, P; Herndon, B; Lee, T; Newswanger, T; Wassall, M

    2012-03-30

    Many obvious and significant concerns arise when considering the concept of small-scale biodiesel production. Does the fuel produced meet the stringent requirements set by the commercial biodiesel industry? Is the process safe? How are small-scale producers collecting and transporting waste vegetable oil? How is waste from the biodiesel production process handled by small-scale producers? These concerns and many others were the focus of the research preformed in the Messiah College Biodiesel Fuel Generation project over the last three years. This project was a unique research program in which undergraduate engineering students at Messiah College set out to research the feasibility of small-biodiesel production for application on a campus of approximately 3000 students. This Department of Energy (DOE) funded research program developed out of almost a decade of small-scale biodiesel research and development work performed by students at Messiah College. Over the course of the last three years the research team focused on four key areas related to small-scale biodiesel production: Quality Testing and Assurance, Process and Processor Research, Process and Processor Development, and Community Education. The objectives for the Messiah College Biodiesel Fuel Generation Project included the following: 1. Preparing a laboratory facility for the development and optimization of processors and processes, ASTM quality assurance, and performance testing of biodiesel fuels. 2. Developing scalable processor and process designs suitable for ASTM certifiable small-scale biodiesel production, with the goals of cost reduction and increased quality. 3. Conduct research into biodiesel process improvement and cost optimization using various biodiesel feedstocks and production ingredients.

  11. Swiss projects for the final disposal of radioactive wastes

    International Nuclear Information System (INIS)

    McCombie, C.

    1987-01-01

    At present, the major part of the discussion does not focus on technical assessment methodology and data, but rather on interpretation of the available geologic data for high-level waste disposal planning. Meanwhile, plans for the implementation of repositories have to be developed. Accordingly, the longer-term studies on high-level waste disposal are proceeding at a pace appropriate for their relatively far-future timescales, and intensified efforts are being put into projects for design, siting, safety assessment and construction of the more urgently required repository for low and intermediate level waste. (orig./PW) [de

  12. Genomics England's implementation of its public engagement strategy: Blurred boundaries between engagement for the United Kingdom's 100,000 Genomes project and the need for public support.

    Science.gov (United States)

    Samuel, Gabrielle Natalie; Farsides, Bobbie

    2018-04-01

    The United Kingdom's 100,000 Genomes Project has the aim of sequencing 100,000 genomes from National Health Service patients such that whole genome sequencing becomes routine clinical practice. It also has a research-focused goal to provide data for scientific discovery. Genomics England is the limited company established by the Department of Health to deliver the project. As an innovative scientific/clinical venture, it is interesting to consider how Genomics England positions itself in relation to public engagement activities. We set out to explore how individuals working at, or associated with, Genomics England enacted public engagement in practice. Our findings show that individuals offered a narrative in which public engagement performed more than one function. On one side, public engagement was seen as 'good practice'. On the other, public engagement was presented as core to the project's success - needed to encourage involvement and ultimately recruitment. We discuss the implications of this in this article.

  13. Prometheus Project Reactor Module Final Report, For Naval Reactors Information

    International Nuclear Information System (INIS)

    MJ Wollman; MJ Zika

    2006-01-01

    The Naval Reactors Prime Contractor Team (NRPCT) led the development of a power plant for a civilian nuclear electric propulsion (NEP) system concept as part of the Prometheus Project. This report provides a summary of the facts, technical insights, and programmatic perspectives gained from this two-year program. The Prometheus Project experience has been extensively documented to better position the US for future space reactor development. Major Technological and engineering challenges exist to develop a system that provides useful electric power from a nuclear fission heat source operating in deep space. General issues include meeting mission requirements in a system that has a mass low enough to launch from earth while assuring public safety and remaining safely shutdown during credible launch accidents. These challenges may be overcome in the future if there is a space mission with a compelling need for nuclear power to drive development. Past experience and notional mission requirements indicate that any useful space reactor system will be unlike past space reactors and existing terrestrial reactors

  14. Community-Level Impacts Projection System (CLIPS). Final report

    Energy Technology Data Exchange (ETDEWEB)

    Monts, J.K.; Bareiss, E.R.

    1979-02-01

    The Community-Level Impacts Projection System includes a set of techniques for providing detailed advance information required for rational planning. The computerized system generates reports which enable the user: to describe the energy development activity in terms of its employment demands and spatial location; to estimate how many in-migrating workers will be required; to estimate the demographic characteristics of the in-migrating workers (e.g., how many elementary school children they will bring); to estimate how many additional secondary employment opportunities (e.g., employment in eating and drinking establishments and grocery stores) will be generated; to estimate what the local area's population levels in various age groups would be both with the project and without it; to estimate community population levels for both the impact case and the baseline case; and to estimate the approximate resource requirements and costs for providing additional municipal facilities and services (e.g., water treatment and distribution, wastewater treatment and collection, gas and electric distribution, police and fire protection, etc.)

  15. Wildlife Impact Assessment Palisades Project, Idaho, Final Report.

    Energy Technology Data Exchange (ETDEWEB)

    Sather-Blair, Signe

    1985-02-01

    The Habitat Evaluation Procedures were used to evaluate pre- and post-construction habitat conditions of the US Bureau of Reclamation's Palisades Project in eastern Idaho. Eight evaluation species were selected with losses expressed in the number of Habitat Units (HU's). One HU is equivalent to one acre of prime habitat. The evaluation estimated that a loss of 2454 HU's of mule deer habitat, 2276 HU's of mink habitat, 2622 HU's of mallard habitat, 805 HU's of Canada goose habitat, 2331 HU's of ruffed grouse habitat, 5941 and 18,565 HU's for breeding and wintering bald eagles, and 1336 and 704 HU's for forested and scrub-shrub wetland nongame species occurred as a result of the project. The study area currently has 29 active osprey nests located around the reservoir and the mudflats probably provide more feeding habitat for migratory shore birds and waterfowl than was previously available along the river. A comparison of flow conditions on the South Fork of the Snake River below the dam between pre- and post-construction periods also could not substantiate claims that water releases from the dam were causing more Canada goose nest losses than flow in the river prior to construction. 41 refs., 16 figs., 9 tabs.

  16. Storage exploratory project. Energy program. Final report; Projet exploratoire Stockage. Programme Energie. Rapport final

    Energy Technology Data Exchange (ETDEWEB)

    Brunet, Y. [Laboratoire d' Electrotechnique de Grenoble, UMR 5529 INPG/UJF - CNRS, ENSIEG, 38 - Saint-Martin-d' Heres (France); Ozil, P. [Laboratoire d' Electrochimie et de Physico-Chimie des Materiaux et des Interfaces (LEPMI), ENSEEG, 38 - Saint Martin d' Heres (France); Cheron, Y. [Laboratoire d' Electrotechnique et d' Electronique Industrielle, CNRS, 31 - Toulouse (France); Multon, B. [Laboratoire des Sciences de l' Information et des Systemes et Applications des Technologies de l' Information et de l' Energie (SATIE), 94 - Cachan (France); Carillo, S. [Centre Interuniversitaire de recherche et d' Ingenierie sur les Materiaux (CIRIMAT), 31 - Toulouse (France)

    2004-07-01

    The aim of this exploratory project was the analysis of the most efficient possibilities of electric power storage. It was limited to the electrochemical storage, the lead batteries which behavior is not completely characterized, the flywheel energy storage and the development of simulation. This report presents the results of the works. (A.L.B.)

  17. Crowdfunding the Azolla fern genome project: a grassroots approach.

    Science.gov (United States)

    Li, Fay-Wei; Pryer, Kathleen M

    2014-01-01

    Much of science progresses within the tight boundaries of what is often seen as a "black box". Though familiar to funding agencies, researchers and the academic journals they publish in, it is an entity that outsiders rarely get to peek into. Crowdfunding is a novel means that allows the public to participate in, as well as to support and witness advancements in science. Here we describe our recent crowdfunding efforts to sequence the Azolla genome, a little fern with massive green potential. Crowdfunding is a worthy platform not only for obtaining seed money for exploratory research, but also for engaging directly with the general public as a rewarding form of outreach.

  18. Fuel Rod Consolidation Project: Phase 2, Final report: Volume 1

    International Nuclear Information System (INIS)

    1987-01-01

    This design report describes the NUS final design of the Prototype Spent Nuclear Fuel Rod Consolidation System. This summary presents the approach and the subsequent sections describe, in detail, the final design. Detailed data, drawings, and the design Basis Accident Report are provided in Volumes II thru V. The design as presented, represents one cell of a multicell facility for the dry consolidation of any type of PWR and BWR fuel used in the United States LWR industry that will exceed 1% of the fuel inventory at the year 2000. The system contains the automatically-controlled equipment required to consolidate 750MT (heavy metal)/year, at 75% availability. The equipment is designed as replaceable components using state-of-the-art tchnology. The control system utilizes the most advanced commercially available equipment on the market today. Two state-of-the-art advanced servo manipulators are provided for system maintenance. In general the equipment is designed utilizing fabricated and commercial components. For example, the main drive systems use commercially available roller screws. These rollers screws have 60,000 hours of operation in nuclear power plants and have been used extensively in other applications. The motors selected represent the most advanced designed servo motors on the market today for the precision control of machinery. In areas where precise positioning was not required, less expensive TRW Globe motors were selected. These are small compact motors with a long history of operations in radiation environments. The Robotic Bridge Transporters are modified versions of existing bridge cranes for remote automatic operations. Other equipment such as the welder for fuel canister closure operations is a commercially available product with an operating history applicable to this process. In general, this approach was followed throughout the design of all the equipment and will enable the system to be developed without costly development programs

  19. Nucla circulating atmospheric fluidized bed demonstration project. Final report

    Energy Technology Data Exchange (ETDEWEB)

    1991-10-01

    Colorado-Ute Electric Association began a study to evaluate options for upgrading and extending the life of its Nucla power station in 1982. Located in southwestern Colorado near the town of Nucla, this station was commissioned in 1959 with a local bituminous coal as its design fuel for three identical stoker-fired units, each rated at 12.6 MW(e). Poor station efficiency, high fuel costs, and spiraling boiler maintenance costs forced the Nucla Station into low priority in the CUEA dispatch order as early as 1981. Among the options CUEA considered was to serve as a host utility to demonstrate Atmospheric Fluidized Bed Combustion (AFBC) technology. The anticipated environmental benefits and apparent attractive economics of a circulating AFBC led to Colorado-Ute`s decision to proceed with the design and construction of a demonstration project in 1984 at the Nucla facility.

  20. Town of Edinburg landfill reclamation demonstration project. Final report

    International Nuclear Information System (INIS)

    1992-01-01

    A landfill reclamation demonstration project was hosted at the Town of Edinburg municipal landfill in northwest Saratoga County, with majority funding provided by the New York State Energy Research and Development Authority. The report examines various separation techniques employed at the site and appropriate uses for reclaimed materials. Specifications regarding engineered work plans, health and safety monitoring, and contingency preparedness are discussed. Major potential applications and benefits of using landfill reclamation technology at existing landfills are identified and discussed. The research and development aspect of the report also examines optimal screening technologies, site selection protocol and the results of a test burn of reclaimed waste at a waste-to-energy facility. Landfill reclamation costs are developed, and economic comparisons are made between reclamation costs and conventional landfill closure costs, with key criteria identified

  1. Final Report for the Soboba Strategic Tribal Energy Planning Project

    Energy Technology Data Exchange (ETDEWEB)

    Miller, Kim [EPA Specialist

    2013-09-17

    In 2011 the Tribe was awarded funds from the Department of Energy to formulate the Soboba Strategic Tribal Energy Plan. This will be a guiding document used throughout the planning of projects focused on energy reduction on the Reservation. The Soboba Strategic Tribal Energy Plan's goal is to create a Five Year Energy Plan for the Soboba Band of Luiseno Indians in San Jacinto, California. This plan will guide the decision making process towards consistent progress leading to the Tribal goal of a 25% reduction in energy consumption in the next five years. It will additionally outline energy usage/patterns and will edentify areas the Tribe can decrease energy use and increase efficiency. The report documents activities undertaken under the grant, as well as incldues the Tribe's strategif energy plan.

  2. Cyprus natural analogue project (CNAP). Phase III final report

    International Nuclear Information System (INIS)

    Alexander, W.R.; Milodowski, A.E.; Pitty, A.F.

    2012-01-01

    The CNAP Phase III project was carried out following identification of the requirement to support ongoing laboratory and modelling efforts on the potential reaction of the bentonite buffer with cementitious leachates in the repository EBS. Although it is known that the higher pH (12.5 to 13) leachates from OPC cement will degrade bentonite, it is unclear if this will also be the case for the lower pH (10 to 11) leachates typical of low alkali cements. Ongoing laboratory and URL programmes which are currently investigating this face the obstacle of slow kinetics and the production of short-lived metastable phases, meaning obtaining unambiguous results may take decades. This is exacerbated by the limitations of the thermodynamic databases for minerals of interest to models of bentonite/low alkali cement leachate reaction. It was therefore decided to implement a focussed NA study on bentonite/low alkali cement leachate reaction to provide indications of likely long-term reaction products and reaction pathways to provide feedback on the existing short-term investigations noted above and to ascertain if any critical path R and D needs to be instigated now. The results of the analyses presented here suggest that there has been very limited alkaline groundwater reaction with the bentonite. This is generally supported by both the geomorphological evidence and the natural decay series data which imply groundwater groundwater/rock interaction in the last 10 5 a. When integrated with the novel data currently being produced in the BIGRAD project, the CNAP data tend to indicate that any long-term bentonite reaction in low alkali cement leachates is minimal. (orig.)

  3. Final Report for Project. Quark matter under extreme conditions

    Energy Technology Data Exchange (ETDEWEB)

    Incera, Vivian [Univ. of Texas, El Paso, TX (United States); Ferrer, Efrain [Univ. of Texas, El Paso, TX (United States)

    2015-12-31

    The results obtained in the two years of the grant have served to shine new light on several important questions about the phases of quantum chromodynamics (QCD) under extreme conditions that include quark matter at high density, as well quark-gluon plasma at high temperatures, both in the presence of strong magnetic fields. The interest in including an external magnetic field on these studies is motivated by the generation of large magnetic fields in off-central heavy-ion collisions and by their common presence in astrophysical compact objects, the two scenarios where the physics of quark matter becomes relevant. The tasks carried out in this DOE project led us, among other things, to discover the first connection between the physics of very dense quark matter and novel materials as for instance topological insulators and Weyl semimetals; they allowed us to find a physical explanation for and a solution to a standing puzzle in the apparent effect of a magnetic field on the critical temperature of the QCD chiral transition; and they led us to establish by the first time that the core of the observed two-solar-mass neutron stars could be made up of quark matter in certain inhomogeneous chiral phases in a magnetic field and that this was consistent with current astrophysical observations. A major goal established by the Nuclear Science Advisory committee in its most recent report “Reaching for the Horizon” has been “to truly understand how nuclei and strongly interacting matter in all its forms behave and can predict their behavior in new settings.” The results found in this DOE project have all contributed to address this goal, and thus they are important for advancing fundamental knowledge in the area of nuclear physics and for enhancing our understanding of the role of strong magnetic fields in the two settings where they are most relevant, neutron stars and heavy-ion collisions.

  4. Cyprus natural analogue project (CNAP). Phase III final report

    Energy Technology Data Exchange (ETDEWEB)

    Alexander, W R [Bedrock Geosciences, Auenstein (Switzerland); Milodowski, A E [British Geological Survey, Keyworth (United Kingdom); Pitty, A F [Pitty (EIA) Consulting, Norwich (United Kingdom)

    2012-01-15

    The CNAP Phase III project was carried out following identification of the requirement to support ongoing laboratory and modelling efforts on the potential reaction of the bentonite buffer with cementitious leachates in the repository EBS. Although it is known that the higher pH (12.5 to 13) leachates from OPC cement will degrade bentonite, it is unclear if this will also be the case for the lower pH (10 to 11) leachates typical of low alkali cements. Ongoing laboratory and URL programmes which are currently investigating this face the obstacle of slow kinetics and the production of short-lived metastable phases, meaning obtaining unambiguous results may take decades. This is exacerbated by the limitations of the thermodynamic databases for minerals of interest to models of bentonite/low alkali cement leachate reaction. It was therefore decided to implement a focussed NA study on bentonite/low alkali cement leachate reaction to provide indications of likely long-term reaction products and reaction pathways to provide feedback on the existing short-term investigations noted above and to ascertain if any critical path R and D needs to be instigated now. The results of the analyses presented here suggest that there has been very limited alkaline groundwater reaction with the bentonite. This is generally supported by both the geomorphological evidence and the natural decay series data which imply groundwater groundwater/rock interaction in the last 10{sup 5} a. When integrated with the novel data currently being produced in the BIGRAD project, the CNAP data tend to indicate that any long-term bentonite reaction in low alkali cement leachates is minimal. (orig.)

  5. Final Report for Project. Quark matter under extreme conditions

    International Nuclear Information System (INIS)

    Incera, Vivian; Ferrer, Efrain

    2015-01-01

    The results obtained in the two years of the grant have served to shine new light on several important questions about the phases of quantum chromodynamics (QCD) under extreme conditions that include quark matter at high density, as well quark-gluon plasma at high temperatures, both in the presence of strong magnetic fields. The interest in including an external magnetic field on these studies is motivated by the generation of large magnetic fields in off-central heavy-ion collisions and by their common presence in astrophysical compact objects, the two scenarios where the physics of quark matter becomes relevant. The tasks carried out in this DOE project led us, among other things, to discover the first connection between the physics of very dense quark matter and novel materials as for instance topological insulators and Weyl semimetals; they allowed us to find a physical explanation for and a solution to a standing puzzle in the apparent effect of a magnetic field on the critical temperature of the QCD chiral transition; and they led us to establish by the first time that the core of the observed two-solar-mass neutron stars could be made up of quark matter in certain inhomogeneous chiral phases in a magnetic field and that this was consistent with current astrophysical observations. A major goal established by the Nuclear Science Advisory committee in its most recent report 'Reaching for the Horizon' has been 'to truly understand how nuclei and strongly interacting matter in all its forms behave and can predict their behavior in new settings.' The results found in this DOE project have all contributed to address this goal, and thus they are important for advancing fundamental knowledge in the area of nuclear physics and for enhancing our understanding of the role of strong magnetic fields in the two settings where they are most relevant, neutron stars and heavy-ion collisions.

  6. Genome-wide analysis of wild-type Epstein-Barr virus genomes derived from healthy individuals of the 1,000 Genomes Project.

    Science.gov (United States)

    Santpere, Gabriel; Darre, Fleur; Blanco, Soledad; Alcami, Antonio; Villoslada, Pablo; Mar Albà, M; Navarro, Arcadi

    2014-04-01

    Most people in the world (∼90%) are infected by the Epstein-Barr virus (EBV), which establishes itself permanently in B cells. Infection by EBV is related to a number of diseases including infectious mononucleosis, multiple sclerosis, and different types of cancer. So far, only seven complete EBV strains have been described, all of them coming from donors presenting EBV-related diseases. To perform a detailed comparative genomic analysis of EBV including, for the first time, EBV strains derived from healthy individuals, we reconstructed EBV sequences infecting lymphoblastoid cell lines (LCLs) from the 1000 Genomes Project. As strain B95-8 was used to transform B cells to obtain LCLs, it is always present, but a specific deletion in its genome sets it apart from natural EBV strains. After studying hundreds of individuals, we determined the presence of natural EBV in at least 10 of them and obtained a set of variants specific to wild-type EBV. By mapping the natural EBV reads into the EBV reference genome (NC007605), we constructed nearly complete wild-type viral genomes from three individuals. Adding them to the five disease-derived EBV genomic sequences available in the literature, we performed an in-depth comparative genomic analysis. We found that latency genes harbor more nucleotide diversity than lytic genes and that six out of nine latency-related genes, as well as other genes involved in viral attachment and entry into host cells, packaging, and the capsid, present the molecular signature of accelerated protein evolution rates, suggesting rapid host-parasite coevolution.

  7. Alligator Rivers Analogue project. Hydrogeological modelling. Final Report - Volume 6

    International Nuclear Information System (INIS)

    Townley, L.R.; Trefry, M.G.; Barr, A.D.; Braumiller, S.

    1992-01-01

    This volume describes hydrogeological modelling carried out as part of the Alligator Rivers Analogue Project. Hydrogeology has played a key integrating role in the Project, largely because water movement is believed to have controlled the evolution of the Koongarra uranium Orebody and therefore affects field observations of all types at all scales. Aquifer testing described uses the concept of transmissivity in its interpretation of aquifer response to pumping. The concept of an aquifer, a layer transmitting significant quantities of water in a mainly horizontal direction, seems hard to accept in an environment as heterogeneous as that at Koongarra. But modelling of aquifers both in one dimension and two dimensionally in plan has contributed significantly to our understanding of the site. A one-dimensional model with three layers (often described as a quasi two dimensional model) was applied to flow between the Fault and Koongarra Creek. Being a transient model, this model was able to show that reverse flows can indeed occur back towards the Fault, but only if there is distributed recharge over the orebody as well as a mechanism for the Fault, or a region near the Fault, to remove water from the simulated cross-section. The model also showed clearly that the response of the three-layered system, consisting of a highly weathered zone, a fractured transmissive zone and a less conductive lower schist zone, is governed mainly by the transmissivity and storage coefficient of the middle layer. The storage coefficient of the higher layer has little effect. A two-dimensional model in plan used a description of anisotropy to show that reverse flows can also occur even without a conducting Fault. Modelling of a three-dimensional region using discrete fractures showed that it is certainly possible to simulate systems like that observed at Koongarra, but that large amounts of data are probably needed to obtain realistic descriptions of the fracture networks. Inverse modelling

  8. USDOE Top-of-Rail Lubricant Project; FINAL

    International Nuclear Information System (INIS)

    Mohumad F. Alzoubi; George R. Fenske; Robert A. Erck; Amrit S. Boparai

    2002-01-01

    Lubrication of wheel/rail systems has been recognized for the last two decades as a very important issue for railroads. Energy savings and less friction and wear can be realized if a lubricant can be used at the wheel/rail interface. On the other hand, adverse influences are seen in operating and wear conditions if improper or excessive lubrication is used. Also, inefficiencies in lubrication need to be avoided for economic and environmental reasons. The top-of-rail (TOR) lubricant concept was developed by Texaco Corporation to lubricate wheels and rails effectively and efficiently. Tranergy Corporation has been developing its SENTRAEN 2000(trademark) lubrication system for the last ten years, and this revolutionary new high-tech on-board rail lubrication system promises to dramatically improve the energy efficiency, performance, safety, and track environment of railroads. The system is fully computer-controlled and ensures that all of the lubricant is consumed as the end of the train passes. Lubricant quantity dispensed is a function of grade, speed, curve, and axle load. Tranergy also has its LA4000(trademark) wheel and rail simulator, a lubrication and traction testing apparatus. The primary task of this project was collecting and analyzing the volatile and semivolatile compounds produced as the lubricant was used. The volatile organic compounds were collected by Carbotrap cartridges and analyzed by adsorption and gas chromatography/mass spectrometry (GC/MS). The semivolatile fraction was obtained by collecting liquid that dripped from the test wheel. The collected material was also analyzed by GC/MS. Both of these analyses were qualitative. The results indicated that in the volatile fraction, the only compounds on the Environmental Protection Agency's (EPA) Superfund List of Analytes detected were contaminants either in the room air or from other potential contamination sources in the laboratory. Similarly, in the semivolatile fraction none of the detected

  9. Alligator Rivers Analogue project. Hydrogeological modelling. Final Report - Volume 6

    Energy Technology Data Exchange (ETDEWEB)

    Townley, L R; Trefry, M G; Barr, A D [CSIRO Div of Water Resources, PO Wembley, WA (Australia); Braumiller, S [Univ of Arizona, Tucson, AZ (United States). Dept of Hydrology and Water Resources; Kawanishi, M [Central Research Institute of Electric Power Industry, Abiko-Shi, Chiba-Ken (Japan); and others

    1993-12-31

    This volume describes hydrogeological modelling carried out as part of the Alligator Rivers Analogue Project. Hydrogeology has played a key integrating role in the Project, largely because water movement is believed to have controlled the evolution of the Koongarra uranium Orebody and therefore affects field observations of all types at all scales. Aquifer testing described uses the concept of transmissivity in its interpretation of aquifer response to pumping. The concept of an aquifer, a layer transmitting significant quantities of water in a mainly horizontal direction, seems hard to accept in an environment as heterogeneous as that at Koongarra. But modelling of aquifers both in one dimension and two dimensionally in plan has contributed significantly to our understanding of the site. A one-dimensional model with three layers (often described as a quasi two dimensional model) was applied to flow between the Fault and Koongarra Creek. Being a transient model, this model was able to show that reverse flows can indeed occur back towards the Fault, but only if there is distributed recharge over the orebody as well as a mechanism for the Fault, or a region near the Fault, to remove water from the simulated cross-section. The model also showed clearly that the response of the three-layered system, consisting of a highly weathered zone, a fractured transmissive zone and a less conductive lower schist zone, is governed mainly by the transmissivity and storage coefficient of the middle layer. The storage coefficient of the higher layer has little effect. A two-dimensional model in plan used a description of anisotropy to show that reverse flows can also occur even without a conducting Fault. Modelling of a three-dimensional region using discrete fractures showed that it is certainly possible to simulate systems like that observed at Koongarra, but that large amounts of data are probably needed to obtain realistic descriptions of the fracture networks. Inverse modelling

  10. The Human Genome Project and the social contract: a law policy approach.

    Science.gov (United States)

    Byk, C

    1992-08-01

    For the first time in history, genetics will enable science to completely identify each human as genetically unique. Will this knowledge reinforce the trend for more individual liberties or will it create a 'brave new world'? A law policy approach to the problems raised by the human genome project shows how far our democratic institutions are from being the proper forum to discuss such issues. Because of the fears and anxiety raised in the population, and also because of its wide implications on the everyday life, the human genome analysis more than any other project needs to succeed in setting up such a social assessment.

  11. Advanced Large Area Plastic Scintillator Project (ALPS): Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Jordan, David V.; Reeder, Paul L.; Todd, Lindsay C.; Warren, Glen A.; McCormick, Kathleen R.; Stephens, Daniel L.; Geelhood, Bruce D.; Alzheimer, James M.; Crowell, Shannon L.; Sliger, William A.

    2008-02-05

    The advanced Large-Area Plastic Scintillator (ALPS) Project at Pacific Northwest National Laboratory investigated possible technological avenues for substantially advancing the state-of-the-art in gamma-ray detection via large-area plastic scintillators. The three predominant themes of these investigations comprised the following: * Maximizing light collection efficiency from a single large-area sheet of plastic scintillator, and optimizing hardware event trigger definition to retain detection efficiency while exploiting the power of coincidence to suppress single-PMT "dark current" background; * Utilizing anti-Compton vetoing and supplementary spectral information from a co-located secondary, or "Back" detector, to both (1) minimize Compton background in the low-energy portion of the "Front" scintillator's pulse-height spectrum, and (2) sharpen the statistical accuracy of the front detector's low-energy response prediction as impelmented in suitable energy-windowing algorithms; and * Investigating alternative materials to enhance the intrinsic gamma-ray detection efficiency of plastic-based sensors.

  12. Project on Alternative Systems Study - PASS. Final report

    International Nuclear Information System (INIS)

    1992-10-01

    Alternative repository systems for deep disposal of spent fuel and different types of canisters are studied regarding technical aspects in Project on Alternative System Study (PASS). The objective is to present a ranking of repository systems as well as of canister types for each system. The studies and compared systems are: KBS-3, Medium Long Tunnels (MLH), Long tunnels (VLH) and Deep Boreholes (VDH). For KBS-3 and MLH five canister types are compared (copper/steel, copper/lead, copper (HIP), steel/lead and steel), for VLH two types (copper/steel and steel), and for VDH three types (titanium/concrete with non-consolidated fuel assemblies, titanium/concrete with consolidated assemblies and copper (HIP) with non-consolidated assemblies). The comparison is separated into three sub-comparisons (Technology, Long-term performance and safety, and Costs), which eventually are merged into one ranking. With respect to canister alternatives the result is that the copper/steel canister is ranked first for KBS-3, MLH and VLH, while the titanium/concrete canister is ranked first for VDH (non-consolidated as well as consolidated assemblies. With these canister alternatives the merged ranking of repository systems results in placing KBS-3 slightly in front of MLH. VLH comes thereafter and VDH last. (32 refs.)

  13. Final 2014 Remedial Action Report Project Chariot, Cape Thompson, Alaska

    Energy Technology Data Exchange (ETDEWEB)

    None, None

    2015-03-01

    This report was prepared to document remedial action (RA) work performed at the former Project Chariot site located near Cape Thompson, Alaska during 2014. The work was managed by the U.S. Army Corps of Engineers (USACE) Alaska District for the U.S. Department of Energy (DOE) Office of Legacy Management (LM). Due to the short field season and the tight barge schedule, all field work was conducted at the site July 6 through September 12, 2014. Excavation activities occurred between July 16 and August 26, 2014. A temporary field camp was constructed at the site prior to excavation activities to accommodate the workers at the remote, uninhabited location. A total of 785.6 tons of petroleum, oil, and lubricants (POL)-contaminated soil was excavated from four former drill sites associated with test holes installed circa 1960. Diesel was used in the drilling process during test hole installations and resulted in impacts to surface and subsurface soils at four of the five sites (no contamination was identified at Test Hole Able). Historic information is not definitive as to the usage for Test Hole X-1; it may have actually been a dump site and not a drill site. In addition to the contaminated soil, the steel test hole casings were decommissioned and associated debris was removed as part of the remedial effort.

  14. Staunton 1 reclamation demonstration project. Aquatic ecosystems. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Vinikour, W. S.

    1981-02-01

    To provide long-term indications of the potential water quality improvements following reclamation efforts at the Staunton 1 Reclamation Demonstration Project, macroinvertebrates were collected from three on-site ponds and from the receiving stream (Cahokia Creek) for site drainage. Implications for potential benthic community differences resulting from site runoff were disclosed, but macroinvertebrate diversity throughout Cahokia Creek was limited due to an unstable, sandy substrate. The three ponds sampled were the New Pond, which was created as part of the reclamation activities; the Shed Pond, which and the Old Pond, which, because it was an existing, nonimpacted pond free of site runoff, served as a control. Comparisons of macroinvertebrates from the ponds indicated the potential for the New Pond to develop into a productive ecosystem. Macroinvertebrates in the New Pond were generally species more tolerant of acid mine drainage conditions. However, due to the present limited faunal densities and the undesirable physical and chemical characteristics of the New Pond, the pond should not be stocked with fish at this time.

  15. Biomass Burning Observation Project (BBOP) Final Campaign Report

    Energy Technology Data Exchange (ETDEWEB)

    Kleinman, LI [Brookhaven National Lab. (BNL), Upton, NY (United States); Sedlacek, A. J. [Brookhaven National Lab. (BNL), Upton, NY (United States)

    2016-01-01

    The Biomass Burning Observation Project (BBOP) was conducted to obtain a better understanding of how aerosols generated from biomass fires affect the atmosphere and climate. It is estimated that 40% of carbonaceous aerosol produced originates from biomass burning—enough to affect regional and global climate. Several biomass-burning studies have focused on tropical climates; however, few campaigns have been conducted within the United States, where millions of acres are burned each year, trending to higher values and greater climate impacts because of droughts in the West. Using the Atmospheric Radiation Measurement (ARM) Aerial Facility (AAF), the BBOP deployed the Gulfstream-1 (G-1) aircraft over smoke plumes from active wildfire and agricultural burns to help identify the impact of these events and how impacts evolve with time. BBOP was one of very few studies that targeted the near-field time evolution of aerosols and aimed to obtain a process-level understanding of the large changes that occur within a few hours of atmospheric processing.

  16. Advanced Large Area Plastic Scintillator Project (ALPS): Final Report

    International Nuclear Information System (INIS)

    Jordan, David V.; Reeder, Paul L.; Todd, Lindsay C.; Warren, Glen A.; McCormick, Kathleen R.; Stephens, Daniel L.; Geelhood, Bruce D.; Alzheimer, James M.; Crowell, Shannon L.; Sliger, William A.

    2008-01-01

    The advanced Large-Area Plastic Scintillator (ALPS) Project at Pacific Northwest National Laboratory investigated possible technological avenues for substantially advancing the state-of-the-art in gamma-ray detection via large-area plastic scintillators. The three predominant themes of these investigations comprised the following: * Maximizing light collection efficiency from a single large-area sheet of plastic scintillator, and optimizing hardware event trigger definition to retain detection efficiency while exploiting the power of coincidence to suppress single-PMT 'dark current' background; * Utilizing anti-Compton vetoing and supplementary spectral information from a co-located secondary, or 'Back' detector, to both (1) minimize Compton background in the low-energy portion of the 'Front' scintillator's pulse-height spectrum, and (2) sharpen the statistical accuracy of the front detector's low-energy response prediction as implemented in suitable energy-windowing algorithms; and * Investigating alternative materials to enhance the intrinsic gamma-ray detection efficiency of plastic-based sensors

  17. Nuclear emergency preparedness. Final report of the Nordic Nuclear Safety Research Project BOK-1

    DEFF Research Database (Denmark)

    Lauritzen, B.

    2002-01-01

    Final report of the Nordic Nuclear Safety Research project BOK-1. The BOK-1 project, “Nuclear Emergency Preparedness”, was carried out in 1998-2001 with participants from the Nordic and Baltic Sea regions. The project consists of six sub-projects:Laboratory measurements and quality assurance (BOK-1.......1); Mobile measurements and measurement strategies (BOK-1.2); Field measurements and data assimilation (BOK-1.3); Countermeasures in agriculture and forestry (BOK-1.4); Emergency monitoring in theNordic and Baltic Sea countries (BOK-1.5); and Nuclear exercises (BOK-1.6). For each sub-project, the project...

  18. Final report: A Broad Research Project in the Sciences of Complexity; FINAL

    International Nuclear Information System (INIS)

    None

    2000-01-01

    Previous DOE support for ''A Broad Research Program in the Sciences of Complexity'' permitted the Santa Fe Institute to initiate new collaborative research within its Integrative Core activities as well as to host visitors to participate in research on specific topics that serve as motivation and testing-ground for the study of general principles of complex systems. The critical aspect of this support is its effectiveness in seeding new areas of research. Indeed, this Integrative Core has been the birthplace of dozens of projects that later became more specifically focused and then won direct grant support independent of the core grants. But at early stages most of this multidisciplinary research was unable to win grant support as individual projects-both because it did not match well with existing grant program guidelines, and because the amount of handing needed was often too modest to justify a formal proposal to an agency. In fact, one of the attributes of core support has been that it permitted SFI to encourage high-risk activities because the cost was quite low. What is significant is how many of those initial efforts have been productive in the SFI environment. Many of SFI'S current research foci began with a short visit from a researcher new to the SFI community, or as small working groups that brought together carefully selected experts from a variety of fields. As mentioned above, many of the ensuing research projects are now being supported by other funding agencies or private foundations. Some of these successes are described

  19. High Performance Building Facade Solutions - PIER Final Project Report

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Eleanor; Selkowitz, Stephen

    2009-12-31

    Building facades directly influence heating and cooling loads and indirectly influence lighting loads when daylighting is considered, and are therefore a major determinant of annual energy use and peak electric demand. Facades also significantly influence occupant comfort and satisfaction, making the design optimization challenge more complex than many other building systems.This work focused on addressing significant near-term opportunities to reduce energy use in California commercial building stock by a) targeting voluntary, design-based opportunities derived from the use of better design guidelines and tools, and b) developing and deploying more efficient glazings, shading systems, daylighting systems, facade systems and integrated controls. This two-year project, supported by the California Energy Commission PIER program and the US Department of Energy, initiated a collaborative effort between The Lawrence Berkeley National Laboratory (LBNL) and major stakeholders in the facades industry to develop, evaluate, and accelerate market deployment of emerging, high-performance, integrated facade solutions. The LBNL Windows Testbed Facility acted as the primary catalyst and mediator on both sides of the building industry supply-user business transaction by a) aiding component suppliers to create and optimize cost effective, integrated systems that work, and b) demonstrating and verifying to the owner, designer, and specifier community that these integrated systems reliably deliver required energy performance. An industry consortium was initiated amongst approximately seventy disparate stakeholders, who unlike the HVAC or lighting industry, has no single representative, multi-disciplinary body or organized means of communicating and collaborating. The consortium provided guidance on the project and more importantly, began to mutually work out and agree on the goals, criteria, and pathways needed to attain the ambitious net zero energy goals defined by California and

  20. The Carolina Bay Restoration Project - Final Report 2000-2006.

    Energy Technology Data Exchange (ETDEWEB)

    Barton, Christopher

    2007-12-15

    A Wetlands Mitigation Bank was established at SRS in 1997 as a compensatory alternative for unavoidable wetland losses. Prior to restoration activities, 16 sites included in the project were surveyed for the SRS Site Use system to serve as a protective covenant. Pre-restoration monitoring ended in Fall 2000, and post restoration monitoring began in the Winter/Spring of 2001. The total interior harvest in the 16 bays after harvesting the trees was 19.6 ha. The margins in the opencanopy, pine savanna margin treatments were thinned. Margins containing areas with immature forested stands (bay 5184 and portions of bay 5011) were thinned using a mechanical shredder in November 2001. Over 126 hectares were included in the study areas (interior + margin). Planting of two tree species and the transplanting of wetland grass species was successful. From field surveys, it was estimated that approximately 2700 Nyssa sylvatica and 1900 Taxodium distichum seedlings were planted in the eight forested bays resulting in an average planting density of ≈ 490 stems ha-1. One hundred seedlings of each species per bay (where available) were marked to evaluate survivability and growth. Wetland grass species were transplanted from donor sites on SRS to plots that ranged in size from 100 – 300 m2, depending on wetland size. On 0.75 and 0.6 meter centers, respectively, 2198 plugs of Panicum hemitomon and 3021 plugs Leersia hexandra were transplanted. New shoots originating from the stumps were treated with a foliar herbicide (Garlon® 4) during the summer of 2001 using backpack sprayers. Preliminary information from 2000-2004 regarding the hydrologic, vegetation and faunal response to restoration is presented in this status report.

  1. Final Report of the HyPER Harvester Project

    Energy Technology Data Exchange (ETDEWEB)

    Prasad, Nadipuram R [New Mexico State Univ., Las Cruces, NM (United States); Ranade, Satishkuma J [New Mexico State Univ., Las Cruces, NM (United States)

    2015-11-30

    The HyPER Harvester Project resulted in the first full­scale design, fabrication and testing of two vertical­axis harvester prototypes at the Elephant Butte Irrigation District Drop 8 Station in Southern New Mexico. The design, followed by fabrication, and deployment clearly demonstrated the feasibility to manufacture and deploy harvester prototypes at low cost. While several issues common to irrigation canal systems have to be overcome, the electromechanical performance of the integrated turbine­generator system demonstrated proof­of­concept. Proof­of­concept includes 1) feasibility for using additive manufacturing techniques to fabricate Carbon­composite turbine­generator components at low cost, 2) ease of transportation and deployment, and 3) the harvester performance. The benefits of modularity were demonstrated in terms of rapid deployment at the Drop 8 Station. Scalability and adaptability were proven in terms of the custom­fitting characteristics that enabled rapid deployment. While keeping the same shape and form, the harvester can be easily adapted to any drop environment. Self­supporting ability makes the harvester design minimally intrusive on existing structures. There are two technical challenges ahead that have to be addressed. Irregular flow patterns in canal flow induce vertical oscillations due to pressure change across the impeller. Despite the nosecone in conventional Kaplan turbine design that ordinarily dampens oscillations, an effective coupling design is required to eliminate the hydrodynamic effect on the generating system. In arid areas where tumbleweed is present, a robust design to prevent trash entering the drop is required. The compact shape and form have an aesthetic appearance and appear to illustrate an environmentally friendly attribute. The systems­engineered design enables rapid manufacturing and assembly of desired size units that can be deployed at sites along U.S. waterways as small hydropower plants. There is

  2. Volcanism Studies: Final Report for the Yucca Mountain Project

    International Nuclear Information System (INIS)

    Crowe, Bruce M.; Perry, Frank V.; Valentine, Greg A.; Bowker, Lynn M.

    1998-01-01

    This report synthesizes the results of volcanism studies conducted by scientists at the Los Alamos National Laboratory and collaborating institutions on behalf of the Department of Energy's Yucca Mountain Project. An assessment of the risk of future volcanic activity is one of many site characterization studies that must be completed to evaluate the Yucca Mountain site for potential long-term storage of high-level radioactive waste. The presence of several basaltic volcanic centers in the Yucca Mountain region of Pliocene and Quaternary age indicates that there is a finite risk of a future volcanic event occurring during the 10,000-year isolation period of a potential repository. Chapter 1 introduces the volcanism issue for the Yucca Mountain site and provides the reader with an overview of the organization, content, and significant conclusions of this report. The risk of future basaltic volcanism is the primary topic of concern including both events that intersect a potential repository and events that occur near or within the waste isolation system of a repository. Future volcanic events cannot be predicted with certainty but instead are estimated using formal methods of probabilistic volcanic hazard assessment (PVHA). Chapter 2 describes the volcanic history of the Yucca Mountain region (YMR) and emphasizes the Pliocene and Quaternary volcanic record, the interval of primary concern for volcanic risk assessment. The distribution, eruptive history, and geochronology of Plio-Quaternary basalt centers are described by individual center emphasizing the younger postcaldera basalt ( than about 7 x 10 -8 events yr -1 . Simple probability estimates are used to assess possible implications of not drilling aeromagnetic anomalies in the Amargosa Valley. The sensitivity of the disruption probability to the location of northeast boundaries of volcanic zones near the Yucca Mountain sit

  3. BACA Project: geothermal demonstration power plant. Final report

    Energy Technology Data Exchange (ETDEWEB)

    1982-12-01

    The various activities that have been conducted by Union in the Redondo Creek area while attempting to develop the resource for a 50 MW power plant are described. The results of the geologic work, drilling activities and reservoir studies are summarized. In addition, sections discussing the historical costs for Union's involvement with the project, production engineering (for anticipated surface equipment), and environmental work are included. Nineteen geothermal wells have been drilled in the Redondo Creek area of the Valles Caldera: a prominent geologic feature of the Jemez mountains consisting of Pliocene and Pleistocene age volcanics. The Redondo Creek area is within a complex longitudinal graben on the northwest flank of the resurgent structural dome of Redondo Peak and Redondo Border. The major graben faults, with associated fracturing, are geologically plausible candidates for permeable and productive zones in the reservoir. The distribution of such permeable zones is too erratic and the locations too imprecisely known to offer an attractive drilling target. Log analysis indicates there is a preferred mean fracture strike of N31W in the upper portion of Redondo Creek wells. This is approximately perpendicular to the major structure in the area, the northeast-striking Redondo Creek graben. The geothermal fluid found in the Redondo Creek reservoir is relatively benign with low brine concentrations and moderate H/sub 2/S concentrations. Geothermometer calculations indicate that the reservoir temperature generally lies between 500/sup 0/F and 600/sup 0/F, with near wellbore flashing occurring during the majority of the wells' production.

  4. Bridging the transatlantic climate divide. Final project paper

    International Nuclear Information System (INIS)

    Kersten, W.C.; Zoeteman, B.C.J.

    2005-10-01

    International climate change policy is presently dominated by the different visions of two major blocks, the USA and EU. It is not always realized that a part of these differences is more fundamental than one may expect in view of the historical connections between the populations of the two continents. Socio-cultural aspects like the role of government, the value of individual liberty and the consequences of population density are different in both regions and play an important role in determining what is acceptable policy-wise. Despite the apparent stalemate in formal positions, signs have been detected that indicate that the 'transatlantic divide' on this issue is (slowly) closing. One cause is that bottom-up momentum is building up in the USA, which can eventually push the federal level to initiate a more active policy. Another cause is the finding in the EU that it turns out to be difficult to reach the Kyoto-targets, which results in the development of policy instruments that could be attractive for the USA to endorse or even participate in. Such instruments could have similarities with the Kyoto Protocol. To obtain more insight in the driving forces behind such changes and why they lead to higher or lower acceptability of certain policy instruments, it makes sense to identify attitudinal indicators that signify such changes. By regularly monitoring these attitudinal indicators, e.g., concrete behavior of companies, proportional media attention, formal political statements, and relating the value of these indicators to a corresponding set of policy instruments, policy makers at both sides of the Atlantic Ocean have an extra tool at their disposal to frame the issue and identify joint solutions in a way that is acceptable to the other party. This project makes a first attempt to design such a method (dynamic analytic model). It holds promises, and it is recommended to develop this model further in order to support the effectiveness of the climate negotiations

  5. Genotype Imputation for Latinos Using the HapMap and 1000 Genomes Project Reference Panels

    Directory of Open Access Journals (Sweden)

    Xiaoyi eGao

    2012-06-01

    Full Text Available Genotype imputation is a vital tool in genome-wide association studies (GWAS and meta-analyses of multiple GWAS results. Imputation enables researchers to increase genomic coverage and to pool data generated using different genotyping platforms. HapMap samples are often employed as the reference panel. More recently, the 1000 Genomes Project resource is becoming the primary source for reference panels. Multiple GWAS and meta-analyses are targeting Latinos, the most populous and fastest growing minority group in the US. However, genotype imputation resources for Latinos are rather limited compared to individuals of European ancestry at present, largely because of the lack of good reference data. One choice of reference panel for Latinos is one derived from the population of Mexican individuals in Los Angeles contained in the HapMap Phase 3 project and the 1000 Genomes Project. However, a detailed evaluation of the quality of the imputed genotypes derived from the public reference panels has not yet been reported. Using simulation studies, the Illumina OmniExpress GWAS data from the Los Angles Latino Eye Study and the MACH software package, we evaluated the accuracy of genotype imputation in Latinos. Our results show that the 1000 Genomes Project AMR+CEU+YRI reference panel provides the highest imputation accuracy for Latinos, and that also including Asian samples in the panel can reduce imputation accuracy. We also provide the imputation accuracy for each autosomal chromosome using the 1000 Genomes Project panel for Latinos. Our results serve as a guide to future imputation-based analysis in Latinos.

  6. Blade System Design Study. Part II, final project report (GEC).

    Energy Technology Data Exchange (ETDEWEB)

    Griffin, Dayton A. (DNV Global Energy Concepts Inc., Seattle, WA)

    2009-05-01

    As part of the U.S. Department of Energy's Low Wind Speed Turbine program, Global Energy Concepts LLC (GEC)1 has studied alternative composite materials for wind turbine blades in the multi-megawatt size range. This work in one of the Blade System Design Studies (BSDS) funded through Sandia National Laboratories. The BSDS program was conducted in two phases. In the Part I BSDS, GEC assessed candidate innovations in composite materials, manufacturing processes, and structural configurations. GEC also made recommendations for testing composite coupons, details, assemblies, and blade substructures to be carried out in the Part II study (BSDS-II). The BSDS-II contract period began in May 2003, and testing was initiated in June 2004. The current report summarizes the results from the BSDS-II test program. Composite materials evaluated include carbon fiber in both pre-impregnated and vacuum-assisted resin transfer molding (VARTM) forms. Initial thin-coupon static testing included a wide range of parameters, including variation in manufacturer, fiber tow size, fabric architecture, and resin type. A smaller set of these materials and process types was also evaluated in thin-coupon fatigue testing, and in ply-drop and ply-transition panels. The majority of materials used epoxy resin, with vinyl ester (VE) resin also used for selected cases. Late in the project, testing of unidirectional fiberglass was added to provide an updated baseline against which to evaluate the carbon material performance. Numerous unidirectional carbon fabrics were considered for evaluation with VARTM infusion. All but one fabric style considered suffered either from poor infusibility or waviness of fibers combined with poor compaction. The exception was a triaxial carbon-fiberglass fabric produced by SAERTEX. This fabric became the primary choice for infused articles throughout the test program. The generally positive results obtained in this program for the SAERTEX material have led to its

  7. From waste to traffic fuel -projects. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Rasi, S; Lehtonen, E; Aro-Heinilae, E [and others

    2012-11-01

    The main objective of the project was to promote biogas production and its use as traffic fuel. The aims in the four Finnish and two Estonian case regions were to reduce the amount and improve the sustainable use of waste and sludge, to promote biogas production, to start biogas use as traffic fuel and to provide tools for implementing the aims. The results of this study show that achieving the food waste prevention target will decrease greenhouse gas emissions by 415 000 CO{sub 2}-eq tons and result in monetary savings for the waste generators amounting to almost 300 euro/ capita on average in all case regions in 2020. The results show that waste prevention should be the first priority in waste management and the use of waste materials as feedstock for energy production the second priority. In total 3 TWh energy could be produced from available biomass in the studied case regions. This corresponds to the fuel consumption of about 300 000 passenger cars. When a Geographical Information System (GIS) was used to identify suitable biogas plant site locations with particular respect to the spatial distribution of available biomass, it was found that a total of 50 biogas plants with capacity varying from 2.1 to 14.5 MW could be built in the case regions. This corresponds to 2.2 TWh energy and covers from 5 to 40% of the passenger car fuel consumption in these regions. Using all produced biogas (2.2 TWh energy) for vehicle fuel GHG emissions would lead to a 450 000 t CO{sub 2}-eq reduction. The same effect on emissions would be gained if more than 100 000 passenger cars were to be taken off the roads. On average, the energy consumed by biogas plants represents approximately 20% of the produced energy. The results also show that biomethane production from waste materials is profitable. In some cases the biomethane production costs can be covered with the gained gate fees. The cost of biomethane production from agricultural materials is less than 96 euro/MWh{sub th

  8. Biohydrogen production by anaerobic fermentation of waste. Final project report

    Energy Technology Data Exchange (ETDEWEB)

    Karakashev, D.; Angelidaki, I.

    2009-01-15

    The objective of this project was to investigate and increase dark fermentative hydrogen production from organic wastes by optimizing important process parameters (reactor type, pH, temperature, organic loading, retention time, inoculation strategy, microbial composition). Labscale experiments were carried out at the Department of Environmental Engineering, Technical University of Denmark. A two steps process for hydrogen production in the first step and methane production in the second step in serial connected fully mixed reactors was developed and could successfully convert organic matter to approx. 20-25 % hydrogen and 15-80 % to methane. Sparging with methane produced in the second stage could significantly increase the hydrogen production. Additionally it was shown that upflow anaerobic sludge blanket (UASB) reactor system was very promising for high effective biohydrogen production from glucose at 70 deg C. Glucose-fed biofilm reactors filled with plastic carriers demonstrated high efficient extreme thermophilic biohydrogen production with mixed cultures. Repeated batch cultivations via exposure of the cultures to increased concentrations of household solid waste was found to be most useful method to enhance hydrogen production rate and reduce lag phase of extreme thermophilic fermentation process. Low level of pH (5.5) at 3-day HRT was enough to inhibit completely the methanogenesis and resulted in stable extreme thermophilic hydrogen production. Homoacetogenisis was proven to be an alternative competitor to biohydrogen production from organic acids under thermophilic (55 deg. C) conditions. With respect to microbiology, 16S rRNA targeted oligonucleotide probes were designed to monitor the spatial distribution of hydrogen producing bacteria in sludge and granules from anaerobic reactors. An extreme thermophilic (70 deg. C), strict anaerobic, mixed microbial culture with high hydrogen producing potential was enriched from digested household waste. Culture

  9. Final Results From the Circumarctic Lakes Observation Network (CALON) Project

    Science.gov (United States)

    Hinkel, K. M.; Arp, C. D.; Eisner, W. R.; Frey, K. E.; Grosse, G.; Jones, B. M.; Kim, C.; Lenters, J. D.; Liu, H.; Townsend-Small, A.

    2015-12-01

    Since 2012, the physical and biogeochemical properties of ~60 lakes in northern Alaska have been investigated under CALON, a project to document landscape-scale variability of Arctic lakes in permafrost terrain. The network has ten nodes along two latitudinal transects extending inland 200 km from the Arctic Ocean. A meteorological station is deployed at each node and six representative lakes instrumented and continuously monitored, with winter and summer visits for synoptic assessment of lake conditions. Over the 4-year period, winter and summer climatology varied to create a rich range of lake responses over a short period. For example, winter 2012-13 was very cold with a thin snowpack producing thick ice across the region. Subsequent years had relatively warm winters, yet regionally variable snow resulted in differing gradients of ice thickness. Ice-out timing was unusually late in 2014 and unusually early in 2015. Lakes are typically well-mixed and largely isothermal, with minor thermal stratification occurring in deeper lakes during calm, sunny periods in summer. Lake water temperature records and morphometric data were used to estimate the ground thermal condition beneath 28 lakes. Application of a thermal equilibrium steady-state model suggests a talik penetrating the permafrost under many larger lakes, but lake geochemical data do not indicate a significant contribution of subpermafrost groundwater. Biogeochemical data reveal distinct spatial and seasonal variability in chlorophyll biomass, chromophoric dissolved organic carbon (CDOM), and major cations/anions. Generally, waters sampled beneath ice in April had distinctly higher concentrations of inorganic solutes and methane compared with August. Chlorophyll concentrations and CDOM absorption were higher in April, suggesting significant biological/biogeochemical activity under lake ice. Lakes are a positive source of methane in summer, and some also emit nitrous oxide and carbon dioxide. As part of the

  10. NEET Micro-Pocket Fission Detector. Final Project report

    Energy Technology Data Exchange (ETDEWEB)

    Unruh, T. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Rempe, Joy [Idaho National Lab. (INL), Idaho Falls, ID (United States); McGregor, Douglas [Idaho National Lab. (INL), Idaho Falls, ID (United States); Ugorowski, Philip [Idaho National Lab. (INL), Idaho Falls, ID (United States); Reichenberger, Michael [Idaho National Lab. (INL), Idaho Falls, ID (United States); Ito, Takashi [Idaho National Lab. (INL), Idaho Falls, ID (United States); Villard, J. -F. [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2014-09-01

    accurately measure the flux and temperature profiles in the reactor. This report summarizes the status at the end of year two of this three year project. As documented in this report, all planned accomplishments for developing this unique new, compact, multipurpose sensor have been completed.

  11. Mississippi Ethanol Gasification Project, Final Scientific / Technical Report

    Energy Technology Data Exchange (ETDEWEB)

    Pearson, Larry, E.

    2007-04-30

    The Mississippi Ethanol (ME) Project is a comprehensive effort to develop the conversion of biomass to ethanol utilizing a proprietary gasification reactor technology developed by Mississippi Ethanol, LLC. Tasks were split between operation of a 1/10 scale unit at the Diagnostic Instrumentation and Analysis Laboratory (DIAL) of Mississippi State University (MSU) and the construction, development, and operation of a full scale pilot unit located at the ME facility in Winona, Mississippi. In addition to characterization of the ME reactor gasification system, other areas considered critical to the operational and economic viability of the overall ME concept were evaluated. These areas include syngas cleanup, biological conversion of syngas to alcohol, and effects of gasification scale factors. Characterization of run data from the Pre-Pilot and Pilot Units has allowed development of the factors necessary for scale-up from the small unit to the larger unit. This scale range is approximately a factor of 10. Particulate and tar sampling gave order of magnitude values for preliminary design calculations. In addition, sampling values collected downstream of the ash removal system show significant reductions in observed loadings. These loading values indicate that acceptable particulate and tar loading rates could be attained with standard equipment additions to the existing configurations. Overall operation both the Pre-Pilot and Pilot Units proceeded very well. The Pilot Unit was operated as a system, from wood receiving to gas flaring, several times and these runs were used to address possible production-scale concerns. Among these, a pressure feed system was developed to allow feed of material against gasifier system pressure with little or no purge requirements. Similarly, a water wash system, with continuous ash collection, was developed, installed, and tested. Development of a biological system for alcohol production was conducted at Mississippi State University with

  12. Characterization of Diesel Combustion inside the EHPC. Final Project

    Energy Technology Data Exchange (ETDEWEB)

    Florent, D.

    2006-07-01

    In part 1 will be discussed the possibility of providing quantitative schlieren with the EHPC (Eindhoven High Pressure Cell) in order to measure temperature. Firstly, some generalities about schlieren are given and the apparatus already used with the EHPC is described. Secondly, the apparatus for quantitative schlieren measurements is described and the mathematical model is explained. Thirdly, we conclude on the possibility of making quantitative schlieren in the EHPC according to the optical components needed and other difficulties. Also two examples will be given of quantitative schlieren study consulted in the literature. In the first one details are discussed of the measurement of the temperature of axisymmetric partially premixed flames (PPFs) established on a coannular burner. The second example details an isothermal helium jet discharged vertically into ambient air. The purpose of this part is to describe most precisely the way of acquiring data from a schlieren image. The different steps are illustrated with some curves and pictures. Next, a summary and analysis is given of the paper published by R. Rubinstein and P. S. Greenberg. In fact, they explain that some functions which are useful for representing axisymmetric refractive index distribution have exact solutions for Abel transformation of the resulting angular deflection data. The objective is to have a better overview on this mathematical step needed to provide quantitative schlieren. Finally, in part 1, a summary is given of the paper published by Douglas A. Feikema. The author presents a numerical analysis based on the software Chemkin and experimental results in order to provide quantitative measurements of the temperature distribution of a spherical diffusion flame using rainbow schlieren deflectometry in normal and microgravity. In fact, the purpose is to discuss the application of quantitative schlieren for a laminar spherical flame. In part 2 the use of some laser diagnostics to study

  13. The 1000 Genomes Project: new opportunities for research and social challenges

    Science.gov (United States)

    2010-01-01

    The 1000 Genomes Project, an international collaboration, is sequencing the whole genome of approximately 2,000 individuals from different worldwide populations. The central goal of this project is to describe most of the genetic variation that occurs at a population frequency greater than 1%. The results of this project will allow scientists to identify genetic variation at an unprecedented degree of resolution and will also help improve the imputation methods for determining unobserved genetic variants that are not represented on current genotyping arrays. By identifying novel or rare functional genetic variants, researchers will be able to pinpoint disease-causing genes in genomic regions initially identified by association studies. This level of detailed sequence information will also improve our knowledge of the evolutionary processes and the genomic patterns that have shaped the human species as we know it today. The new data will also lay the foundation for future clinical applications, such as prediction of disease susceptibility and drug response. However, the forthcoming availability of whole genome sequences at affordable prices will raise ethical concerns and pose potential threats to individual privacy. Nevertheless, we believe that these potential risks are outweighed by the benefits in terms of diagnosis and research, so long as rigorous safeguards are kept in place through legislation that prevents discrimination on the basis of the results of genetic testing. PMID:20193048

  14. Pine Gene Discovery Project - Final Report - 08/31/1997 - 02/28/2001; FINAL

    International Nuclear Information System (INIS)

    Whetten, R. W.; Sederoff, R. R.; Kinlaw, C.; Retzel, E.

    2001-01-01

    Integration of pines into the large scope of plant biology research depends on study of pines in parallel with study of annual plants, and on availability of research materials from pine to plant biologists interested in comparing pine with annual plant systems. The objectives of the Pine Gene Discovery Project were to obtain 10,000 partial DNA sequences of genes expressed in loblolly pine, to determine which of those pine genes were similar to known genes from other organisms, and to make the DNA sequences and isolated pine genes available to plant researchers to stimulate integration of pines into the wider scope of plant biology research. Those objectives have been completed, and the results are available to the public. Requests for pine genes have been received from a number of laboratories that would otherwise not have included pine in their research, indicating that progress is being made toward the goal of integrating pine research into the larger molecular biology research community

  15. Volcanism Studies: Final Report for the Yucca Mountain Project

    Energy Technology Data Exchange (ETDEWEB)

    Bruce M. Crowe; Frank V. Perry; Greg A. Valentine; Lynn M. Bowker

    1998-12-01

    This report synthesizes the results of volcanism studies conducted by scientists at the Los Alamos National Laboratory and collaborating institutions on behalf of the Department of Energy's Yucca Mountain Project. An assessment of the risk of future volcanic activity is one of many site characterization studies that must be completed to evaluate the Yucca Mountain site for potential long-term storage of high-level radioactive waste. The presence of several basaltic volcanic centers in the Yucca Mountain region of Pliocene and Quaternary age indicates that there is a finite risk of a future volcanic event occurring during the 10,000-year isolation period of a potential repository. Chapter 1 introduces the volcanism issue for the Yucca Mountain site and provides the reader with an overview of the organization, content, and significant conclusions of this report. The risk of future basaltic volcanism is the primary topic of concern including both events that intersect a potential repository and events that occur near or within the waste isolation system of a repository. Future volcanic events cannot be predicted with certainty but instead are estimated using formal methods of probabilistic volcanic hazard assessment (PVHA). Chapter 2 describes the volcanic history of the Yucca Mountain region (YMR) and emphasizes the Pliocene and Quaternary volcanic record, the interval of primary concern for volcanic risk assessment. The distribution, eruptive history, and geochronology of Plio-Quaternary basalt centers are described by individual center emphasizing the younger postcaldera basalt (<5 Ma). The Lathrop Wells volcanic center is described in detail because it is the youngest basalt center in the YMR. The age of the Lathrop Wells center is now confidently determined to be about 75 thousand years old. Chapter 3 describes the tectonic setting of the YMR and presents and assesses the significance of multiple alternative tectonic models. The Crater Flat volcanic zone is

  16. The RadGenomics project. Prediction for radio-susceptibility of individuals with genetic predisposition

    International Nuclear Information System (INIS)

    Imai, Takashi

    2003-01-01

    The ultimate goal of our project, named RadGenomics, is to elucidate the heterogeneity of the response to ionizing radiation arising from genetic variation among individuals, for the purpose of developing personalized radiation therapy regimens for cancer patients. Cancer patients exhibit patient-to-patient variability in normal tissue reactions after radiotherapy. Several observations support the hypothesis that the radiosensitivity of normal tissue is influenced by genetic factors. The rapid progression of human genome sequencing and the recent development of new technologies in molecular biology are providing new opportunities for elucidating the genetic basis of individual differences in susceptibility to radiation exposure. The development of a sufficiently robust, predictive assay enabling individual dose adjustment would improve the outcome of radiation therapy in patients. Our strategy for identification of DNA polymorphisms that contribute to the individual radiosensitivity is as follows. First, we have been categorizing DNA samples obtained from cancer patients, who have been kindly introduced to us through many collaborators, according to their clinical characteristics including the method and effect of treatment and side effects as scored by toxicity criteria, and also the result of an in vitro radiosensitivity assay, e.g., the micronuclei assay of their lymphocytes. Second, we have identified candidate genes for genotyping mainly by using our custom-designed oligonucleotide array with RNA samples, in which the probes were obtained from more than 40 cancer and 3 fibroblast cell lines whose radiosensitivity level was quite heterogeneous. We have also been studying the modification of proteins after irradiation of cells which may be caused by mainly phosphorylation or dephosphorylation, using mass spectrometry. Genes encoding the modified proteins and/or other proteins with which they interact such as specific protein kinases and phosphatases are also

  17. The New Mexico Technology Deployment Pilot Project: A technology reinvestment project. Final report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-11-01

    The New Mexico Technology Deployment Project (NMTDP) has been in operation for slightly more than two years. As one of the original TRP projects, NMTDP had the charter to develop and validate a new model for technology extraction which emphasized focused technology collaboration, early industry involvement, and a strong dual use commercialization and productization emphasis. Taken in total, the first two years of the NMTDP have been exceptionally successful, surpassing the goals of the project. This report describes the accomplishments and evolution of the NMTDP to date and discusses the future potential of the project. Despite the end of federal funding, and a subsequent reduction in level of effort, the project partners are committed to continuation of the project.

  18. Functional food ingredients against colorectal cancer. An example project integrating functional genomics, nutrition and health

    NARCIS (Netherlands)

    Stierum, R.; Burgemeister, R.; Helvoort, van A.; Peijnenburg, A.; Schütze, K.; Seidelin, M.; Vang, O.; Ommen, van B.

    2001-01-01

    Functional Food Ingredients Against Colorectal Cancer is one of the first European Union funded Research Projects at the cross-road of functional genomics [comprising transcriptomics, the measurement of the expression of all messengers RNA (mRNAs) and proteomics, the measurement of expression/state

  19. The Human Genome Project and Eugenics: Identifying the Impact on Individuals with Mental Retardation.

    Science.gov (United States)

    Kuna, Jason

    2001-01-01

    This article explores the impact of the mapping work of the Human Genome Project on individuals with mental retardation and the negative effects of genetic testing. The potential to identify disabilities and the concept of eugenics are discussed, along with ethical issues surrounding potential genetic therapies. (Contains references.) (CR)

  20. Reflections on Mental Retardation and Eugenics, Old and New: Mensa and the Human Genome Project.

    Science.gov (United States)

    Smith, J. David

    1994-01-01

    This article addresses the moral and ethical issues of mental retardation and a continuing legacy of belief in eugenics. It discusses the involuntary sterilization of Carrie Buck in 1927, support for legalized killing of subnormal infants by 47% of respondents to a Mensa survey, and implications of the Human Genome Project for the field of mental…

  1. Democratizing Human Genome Project Information: A Model Program for Education, Information and Debate in Public Libraries.

    Science.gov (United States)

    Pollack, Miriam

    The "Mapping the Human Genome" project demonstrated that librarians can help whomever they serve in accessing information resources in the areas of biological and health information, whether it is the scientists who are developing the information or a member of the public who is using the information. Public libraries can guide library…

  2. From Mendel to the Human Genome Project: The Implications for Nurse Education.

    Science.gov (United States)

    Burton, Hilary; Stewart, Alison

    2003-01-01

    The Human Genome Project is brining new opportunities to predict and prevent diseases. Although pediatric nurses are the closest to these developments, most nurses will encounter genetic aspects of practice and must understand the basic science and its ethical, legal, and social dimensions. (Includes commentary by Peter Birchenall.) (SK)

  3. U.S. LCI Database Project--Final Phase I Report

    Energy Technology Data Exchange (ETDEWEB)

    2003-08-01

    This Phase I final report reviews the process and provides a plan for the execution of subsequent phases of the database project, including recommended data development priorities and a preliminary cost estimate. The ultimate goal of the project is to develop publicly available LCI Data modules for commonly used materials, products, and processes.

  4. Analysis of final year DVM research projects submitted to the Faculty ...

    African Journals Online (AJOL)

    This study analyzed the intellectual output of the undergraduate final year students. research projects submitted to the Faculty of Veterinary Medicine, Usmanu Danfodiyo University, Sokoto, from 1994 to 2004. The findings of the study show that a total of 194 research projects were produced within the period under study.

  5. The Elder Abuse Prevention Project, Phase Two, Three and Four. Final Report.

    Science.gov (United States)

    Regina Univ. (Saskatchewan). Univ. Extension. Seniors Education Centre.

    This document presents the final report from an educational and community development program designed to raise awareness about the abuse and neglect of the elderly. The Elder Abuse Prevention Project is briefly described in terms of project goals, objectives, the model used, the target groups served, and the evaluation processes employed. It is…

  6. Energy final consumption projection - 1985/2005 - basic scenery - Minas Gerais State

    International Nuclear Information System (INIS)

    1989-03-01

    A projection of the final energy consumption study for the Minas Gerais State until 2005 year is presented. The conclusion of this projection shows a increasing of 108,8% for the total energy. The industries will be response for 62,0% and the transport sector will use 20,7% of the total energy in 2005. (L.J.C.)

  7. Final Technical Report on the Genome Sequence DataBase (GSDB): DE-FG03 95 ER 62062 September 1997-September 1999; FINAL

    International Nuclear Information System (INIS)

    Harger, Carol A.

    1999-01-01

    Since September 1997 NCGR has produced two web-based tools for researchers to use to access and analyze data in the Genome Sequence DataBase (GSDB). These tools are: Sequence Viewer, a nucleotide sequence and annotation visualization tool, and MAR-Finder, a tool that predicts, base upon statistical inferences, the location of matrix attachment regions (MARS) within a nucleotide sequence.[The annual report for June 1996 to August 1997 is included as an attachment to this final report.

  8. Final report for the 'Melt-Vessel Interactions' Project. European Union R and TD Program 4th Framework. MVI project final research report

    Energy Technology Data Exchange (ETDEWEB)

    Sehgal, B.R.; Dinh, T.N.; Nourgaliev, R.R.; Bui, V.A.; Green, J.; Kolb, G.; Karbojian, A.; Theerthan, S.A.; Gubaidulline, A. [Royal Inst. of Tech., Stockholm (Sweden). Div. of Nuclear Power Safety; Helle, M.; Kymaelaeinen, O.; Tuomisto, H. [IVO Power Engineering Ltd., Vantaa (Finland); Bonnet, J.M.; Rouge, S.; Narcoux, M.; Liegeois, A. [CEA - Grenoble (France); Turland, B.D.; Dobson, G.P. [AEA Technology plc, Dorchester (United Kingdom); Siccama, A. [ECN Nuclear Research, Petten (Netherlands); Ikonen, K. [VTT Energy, Helsinki (Finland); Parozzi, F. [ENEL - SRI/PAM/GRA, Segrate, MI (Italy); Kolev, N. [Siemens AG, Erlangen (Germany); Caira, M. [Univ. of Roma (Italy)

    1999-04-01

    The Melt Vessel Interaction (MVI) project is concerned with the consequences of the interactions that a core melt, generated during a postulated severe accident in a light water reactor, may have with the pressure vessel. In particular, the issues concerned with the failure of the vessel bottom head are the focus of the research. The specific objectives of the project are to obtain data and develop validated models, which could be applied to prototypic plants, and accident conditions, for resolution of issues related to the melt vessel interactions. The project work has been performed by nine partners having varied responsibility. The work included a large number of experiments, with simulant materials, whose observations and results are employed, respectively, to understand the physical mechanisms and to develop validated models. Applications to the prototypic geometry and conditions have also been performed. This report is volume 1 of the Final Report for the Project, in which a summary of the progress achieved in the experimental program is provided. We have, however, included some aspects of the modeling activities. Volume 2 of the Final report describes the progress achieved in the modeling program. The progress achieved in the experimental and modeling parts of the Project has led to the resolution of some of the issues of melt vessel interaction. Considerable progress was also achieved towards resolution of the remaining issues.

  9. Final report for the 'Melt-Vessel Interactions' Project. European Union R and TD Program 4th Framework. MVI project final research report

    International Nuclear Information System (INIS)

    Sehgal, B.R.; Dinh, T.N.; Nourgaliev, R.R.; Bui, V.A.; Green, J.; Kolb, G.; Karbojian, A.; Theerthan, S.A.; Gubaidulline, A.; Bonnet, J.M.; Rouge, S.; Narcoux, M.; Liegeois, A.; Turland, B.D.; Dobson, G.P.; Siccama, A.; Ikonen, K.; Parozzi, F.; Kolev, N.; Caira, M.

    1999-04-01

    The Melt Vessel Interaction (MVI) project is concerned with the consequences of the interactions that a core melt, generated during a postulated severe accident in a light water reactor, may have with the pressure vessel. In particular, the issues concerned with the failure of the vessel bottom head are the focus of the research. The specific objectives of the project are to obtain data and develop validated models, which could be applied to prototypic plants, and accident conditions, for resolution of issues related to the melt vessel interactions. The project work has been performed by nine partners having varied responsibility. The work included a large number of experiments, with simulant materials, whose observations and results are employed, respectively, to understand the physical mechanisms and to develop validated models. Applications to the prototypic geometry and conditions have also been performed. This report is volume 1 of the Final Report for the Project, in which a summary of the progress achieved in the experimental program is provided. We have, however, included some aspects of the modeling activities. Volume 2 of the Final report describes the progress achieved in the modeling program. The progress achieved in the experimental and modeling parts of the Project has led to the resolution of some of the issues of melt vessel interaction. Considerable progress was also achieved towards resolution of the remaining issues

  10. Characterization of the radon source in North-Central Florida. Final report part 1 -- Final project report; Final report part 2 -- Technical report

    International Nuclear Information System (INIS)

    1997-01-01

    This report contains two separate parts: Characterization of the Radon Source in North-Central Florida (final report part 1 -- final project report); and Characterization of the Radon Source in North-Central Florida (technical report). The objectives were to characterize the radon 222 source in a region having a demonstrated elevated indoor radon potential and having geology, lithology, and climate that are different from those in other regions of the U.S. where radon is being studied. Radon availability and transport in this region were described. Approaches for predicting the radon potential of lands in this region were developed

  11. 360 Degrees Project: Final Report of 1972-73. National Career Education Television Project.

    Science.gov (United States)

    Wisconsin Univ., Madison. Univ. Extension.

    Project 360 Degrees was a mass-media, multi-State, one-year effort in adult career education initiated by WHA-TV, the public television station of the University of Wisconsin-Extension, and funded by the U.S. Office of Education. The overall goal of the project was to provide, through a coordinated media system, information and motivation that…

  12. A ProCoS II Project Final Report: ESPRIT Basic Research project 707

    DEFF Research Database (Denmark)

    Bowen, J. P.; Hoare, C. A. R.; Langmaack, Hans

    1996-01-01

    An overview of the research and associated activities of the Europeancollaborative ESPRIT Basic Research ProCoS II project (no. 7071) on``Provably Correct Systems'' which ran from 1992 to 1995 is presented.This was a follow-on project to ProCoS (no. 3104) and ran inparallel with the ProCoS Working...

  13. Genome Writing: Current Progress and Related Applications

    Directory of Open Access Journals (Sweden)

    Yueqiang Wang

    2018-02-01

    Full Text Available The ultimate goal of synthetic biology is to build customized cells or organisms to meet specific industrial or medical needs. The most important part of the customized cell is a synthetic genome. Advanced genomic writing technologies are required to build such an artificial genome. Recently, the partially-completed synthetic yeast genome project represents a milestone in this field. In this mini review, we briefly introduce the techniques for de novo genome synthesis and genome editing. Furthermore, we summarize recent research progresses and highlight several applications in the synthetic genome field. Finally, we discuss current challenges and future prospects. Keywords: Synthetic biology, Genome writing, Genome editing, Bioethics, Biosafety

  14. Decontamination and decommissioning of the Experimental Boiling Water Reactor (EBWR): Project final report, Argonne National Laboratory

    International Nuclear Information System (INIS)

    Fellhauer, C.R.; Boing, L.E.; Aldana, J.

    1997-03-01

    The Final Report for the Decontamination and Decommissioning (D ampersand D) of the Argonne National Laboratory - East (ANL-E) Experimental Boiling Water Reactor (EBWR) facility contains the descriptions and evaluations of the activities and the results of the EBWR D ampersand D project. It provides the following information: (1) An overall description of the ANL-E site and EBWR facility. (2) The history of the EBWR facility. (3) A description of the D ampersand D activities conducted during the EBWR project. (4) A summary of the final status of the facility, including the final and confirmation surveys. (5) A summary of the final cost, schedule, and personnel exposure associated with the project, including a summary of the total waste generated. This project report covers the entire EBWR D ampersand D project, from the initiation of Phase I activities to final project closeout. After the confirmation survey, the EBWR facility was released as a open-quotes Radiologically Controlled Area,close quotes noting residual elevated activity remains in inaccessible areas. However, exposure levels in accessible areas are at background levels. Personnel working in accessible areas do not need Radiation Work Permits, radiation monitors, or other radiological controls. Planned use for the containment structure is as an interim transuranic waste storage facility (after conversion)

  15. 77 FR 62256 - Notice of Availability of the Final Environmental Impact Statement for the Mount Hope Project...

    Science.gov (United States)

    2012-10-12

    ... of the Final Environmental Impact Statement for the Mount Hope Project, Eureka County, NE AGENCY... prepared a Final Environmental Impact Statement (EIS) for the Mount Hope Project and by this notice is... Register. ADDRESSES: Copies of the Mount Hope Project Final EIS are available at the Battle Mountain...

  16. Final Report: Connecting genomic capabilities to physiology and response: Systems biology of the widespread alga Micromonas

    Energy Technology Data Exchange (ETDEWEB)

    Worden, Alexandra Z. [Monterey Bay Aquarium Research Institute (MBARI), Moss Landing, CA (United States); Callister, Stephen [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Stuart, Joshua [Univ. of California, Santa Cruz, CA (United States); Smith, Richard [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2014-09-30

    Increased stratification, less mixing and reduced nutrient concentrations in marine surface waters are predicted under a number of climate-change scenarios. These conditions are considered favorable for tiny photosynthetic algae (picophytoplankton), shaping their role in mediating future CO2 conditions. One possibility is that picophytoplankton such as Micromonas that have broad geographical ranges will more successfully adapt to changing environmental conditions. However, their capacity to thrive under the multi-factorial impacts of low pH, low nutrients, increasing temperature and changes in community composition is not known. Here, we developed the dual-Micromonas model system, which entailed generating optimized genomic information for two Micromonas species and developing a highperformance chemostat system in which both CO2 and nutrients could be consistently manipulated. This system is now fully operational. Project results are available in several publications will others are still in the analysis phase. Overall, our results show that Micromonas primary production will likely decrease under predicted future climate conditions. Furthermore, our studies on Micromonas provide new insights to the land plant ancestor, including the discovery of conserved signaling mechanisms (known to be essential to plant development) as well as the discovery of widespread chemical-sensing molecular switches. Collectively, this research highlights Micromonas as an important new model green alga for understanding plant gene networks and evolution as well as for investigating perturbation effects on marine primary production.

  17. Getting the Word Out on the Human Genome Project: A Course for Physicians

    Energy Technology Data Exchange (ETDEWEB)

    Sara L. Tobin

    2004-09-29

    Our project, ''Getting the Word Out on the Human Genome Project: A Course for Physicians,'' presented educational goals to convey the power and promise of the Human Genome Program to a variety of professional, educational, and public audiences. Our initial goal was to provide practicing physicians with a comprehensive multimedia tool to update their skills in the genomic era. We therefore created the multimedia courseware, ''The New Genetics: Courseware for Physicians. Molecular Concepts, Applications, and Ramifications.'' However, as the project moved forward, several unanticipated audiences found the courseware to be useful for instruction and for self-education, so an additional edition of the courseware ''The New Genetics: Medicine and the Human Genome. Molecular Concepts, Applications, and Ramifications'' was published simultaneously with the physician version. At the time that both versions of the courseware were being completed, Stanford's Office of Technology Licensing opted not to commercialize the courseware and offered a license-back agreement if the authors founded a commercial business. The authors thus became closely involved in marketing and sales, and several thousand copies of the courseware have been sold. Surprisingly, the non-physician version has turned out to be more in demand, and this has led us in several new directions, most of which involve undergraduate education. These are discussed in detail in the Report.

  18. Genomics: The Science and Technology Behind the Human Genome Project (by Charles R. Cantor and Cassandra L. Smith)

    Science.gov (United States)

    Serra, Reviewed By Martin J.

    2000-01-01

    analysis of error in sequencing and current bottlenecks in the sequencing effort. The next chapter describes the steps necessary to scale current technologies for the sequencing of entire genomes. Chapter 12 examines alternate methods for DNA sequencing. Initially, methods of single-molecule sequencing and sequencing by microscopy are introduced; the majority of the chapter is devoted to the development of DNA sequencing methods using chip microarrays and hybridization. The remaining chapters (13-15) consider the uses and analysis of DNA sequence information. The initial focus is on the identification of genes. Several examples are given of the use of DNA sequence information for diagnosis of inherited or infectious diseases. The sequence-specific manipulation of DNA is discussed in Chapter 14. The final chapter deals with the implications of large-scale sequencing, including methods for identifying genes and finding errors in DNA sequences, to the development of computer algorithms for the interpretation of DNA sequence information. The text figures are black and white line drawings that, although clearly done, seem a bit primitive for 1999. While I appreciated the simplicity of the drawings, many students accustomed to more colorful presentations will find them wanting. The four color figures in the center of the text seem an afterthought and add little to the text's clarity. Each chapter has a set of additional reading sources, mostly primary sources. Often, specialized topics are offset into boxes that provide clarification and amplification without cluttering the text. An appendix includes a list of the Web-based database resources. As an undergraduate instructor who has previously taught biochemistry, molecular biology, and a course on the human genome, I found many interesting tidbits and amplifications throughout the text. I would recommend this book as a text for an advanced undergraduate or beginning graduate course in genomics. Although the text works though

  19. Identification of balanced chromosomal rearrangements previously unknown among participants in the 1000 Genomes Project: implications for interpretation of structural variation in genomes and the future of clinical cytogenetics.

    Science.gov (United States)

    Dong, Zirui; Wang, Huilin; Chen, Haixiao; Jiang, Hui; Yuan, Jianying; Yang, Zhenjun; Wang, Wen-Jing; Xu, Fengping; Guo, Xiaosen; Cao, Ye; Zhu, Zhenzhen; Geng, Chunyu; Cheung, Wan Chee; Kwok, Yvonne K; Yang, Huanming; Leung, Tak Yeung; Morton, Cynthia C; Cheung, Sau Wai; Choy, Kwong Wai

    2017-11-02

    PurposeRecent studies demonstrate that whole-genome sequencing enables detection of cryptic rearrangements in apparently balanced chromosomal rearrangements (also known as balanced chromosomal abnormalities, BCAs) previously identified by conventional cytogenetic methods. We aimed to assess our analytical tool for detecting BCAs in the 1000 Genomes Project without knowing which bands were affected.MethodsThe 1000 Genomes Project provides an unprecedented integrated map of structural variants in phenotypically normal subjects, but there is no information on potential inclusion of subjects with apparent BCAs akin to those traditionally detected in diagnostic cytogenetics laboratories. We applied our analytical tool to 1,166 genomes from the 1000 Genomes Project with sufficient physical coverage (8.25-fold).ResultsWith this approach, we detected four reciprocal balanced translocations and four inversions, ranging in size from 57.9 kb to 13.3 Mb, all of which were confirmed by cytogenetic methods and polymerase chain reaction studies. One of these DNAs has a subtle translocation that is not readily identified by chromosome analysis because of the similarity of the banding patterns and size of exchanged segments, and another results in disruption of all transcripts of an OMIM gene.ConclusionOur study demonstrates the extension of utilizing low-pass whole-genome sequencing for unbiased detection of BCAs including translocations and inversions previously unknown in the 1000 Genomes Project.GENETICS in MEDICINE advance online publication, 2 November 2017; doi:10.1038/gim.2017.170.

  20. The AGP-Project conceptual design for a Spanish HLW final disposal facility

    International Nuclear Information System (INIS)

    Biurrun, E.; Engelmann, H.-J.; Huertas, F.; Ulibarri, A.

    1992-01-01

    Within the framework of the AGP Project a Conceptual Design for a HLW Final Disposal Facility to be eventually built in an underground salt formation in Spain has been developed. The AGP Project has the character of a system analysis. In the current project phase I several alternatives has been considered for different subsystems and/or components of the repository. The system variants, developed to such extent as to allow a comparison of their advantages and disadvantages, will allow the selection of a reference concept, which will be further developed to technical maturity in subsequent project phases. (author)

  1. Hellsgate Winter Range Mitigation Project; Long-term Management Plan, Project Report 1993, Final Draft.

    Energy Technology Data Exchange (ETDEWEB)

    Berger, Matthew T.

    1994-01-01

    A study was conducted on the Hellsgate Winter Range Mitigation Project area, a 4,943 acre ranch purchased for mitigating some habitat losses associated with the original construction of Grand Coulee Dam and innundation of habitat by Lake Roosevelt. A Habitat Evaluation Procedure (HEP) study was used to determine habitat quality and quantity baseline data and future projections. Target species used in the study were sharp-tailed grouse (Tympanuchus phasianellus), mule deer (Odocoileus hemoinus), mink (Mustela vison), spotted sandpiper (Actiius colchicus), bobcat (Felis reufs), blue grouse (Dendragapus obscurus), and mourning dove (Zenaida macroura). From field data collected, limiting life values or HSI's (Habitat Suitability Index's) for each indicator species was determined for existing habitats on project lands. From this data a long term management plan was developed. This report is designed to provide guidance for the management of project lands in relation to the habitat cover types discussed and the indicator species used to evaluate these cover types. In addition, the plan discusses management actions, habitat enhancements, and tools that will be used to enhance, protect and restore habitats to desired conditions. Through planned management actions biodiversity and vegetative structure can be optimized over time to reduce or eliminate, limiting HSI values for selected wildlife on project lands.

  2. SOLERAS - Solar Controlled Environment Agriculture Project. Final report, Volume 1. Project summary

    Energy Technology Data Exchange (ETDEWEB)

    1985-12-30

    A summary of the Solar Controlled Environment Agriculture Project is presented. The design of the greenhouses include transparent double pane glass roof with channels for fluid between the panes, inner pane tinted and double pane extruded acrylic aluminized mylar shade and diffuser. Solar energy technologies provide power for water desalination, for pumping irrigation water, and for cooling and heating the controlled environment space so that crops can grow in arid lands. The project is a joint effort between the United States and Saudi Arabia. (BCS)

  3. Earth BioGenome Project: Sequencing life for the future of life.

    Science.gov (United States)

    Lewin, Harris A; Robinson, Gene E; Kress, W John; Baker, William J; Coddington, Jonathan; Crandall, Keith A; Durbin, Richard; Edwards, Scott V; Forest, Félix; Gilbert, M Thomas P; Goldstein, Melissa M; Grigoriev, Igor V; Hackett, Kevin J; Haussler, David; Jarvis, Erich D; Johnson, Warren E; Patrinos, Aristides; Richards, Stephen; Castilla-Rubio, Juan Carlos; van Sluys, Marie-Anne; Soltis, Pamela S; Xu, Xun; Yang, Huanming; Zhang, Guojie

    2018-04-24

    Increasing our understanding of Earth's biodiversity and responsibly stewarding its resources are among the most crucial scientific and social challenges of the new millennium. These challenges require fundamental new knowledge of the organization, evolution, functions, and interactions among millions of the planet's organisms. Herein, we present a perspective on the Earth BioGenome Project (EBP), a moonshot for biology that aims to sequence, catalog, and characterize the genomes of all of Earth's eukaryotic biodiversity over a period of 10 years. The outcomes of the EBP will inform a broad range of major issues facing humanity, such as the impact of climate change on biodiversity, the conservation of endangered species and ecosystems, and the preservation and enhancement of ecosystem services. We describe hurdles that the project faces, including data-sharing policies that ensure a permanent, freely available resource for future scientific discovery while respecting access and benefit sharing guidelines of the Nagoya Protocol. We also describe scientific and organizational challenges in executing such an ambitious project, and the structure proposed to achieve the project's goals. The far-reaching potential benefits of creating an open digital repository of genomic information for life on Earth can be realized only by a coordinated international effort.

  4. Citrus sinensis annotation project (CAP): a comprehensive database for sweet orange genome.

    Science.gov (United States)

    Wang, Jia; Chen, Dijun; Lei, Yang; Chang, Ji-Wei; Hao, Bao-Hai; Xing, Feng; Li, Sen; Xu, Qiang; Deng, Xiu-Xin; Chen, Ling-Ling

    2014-01-01

    Citrus is one of the most important and widely grown fruit crop with global production ranking firstly among all the fruit crops in the world. Sweet orange accounts for more than half of the Citrus production both in fresh fruit and processed juice. We have sequenced the draft genome of a double-haploid sweet orange (C. sinensis cv. Valencia), and constructed the Citrus sinensis annotation project (CAP) to store and visualize the sequenced genomic and transcriptome data. CAP provides GBrowse-based organization of sweet orange genomic data, which integrates ab initio gene prediction, EST, RNA-seq and RNA-paired end tag (RNA-PET) evidence-based gene annotation. Furthermore, we provide a user-friendly web interface to show the predicted protein-protein interactions (PPIs) and metabolic pathways in sweet orange. CAP provides comprehensive information beneficial to the researchers of sweet orange and other woody plants, which is freely available at http://citrus.hzau.edu.cn/.

  5. Phase II Final Project Report SBIR Project: "A High Efficiency PV to Hydrogen Energy System"

    Energy Technology Data Exchange (ETDEWEB)

    Slade, A; Turner, J; Stone, K; McConnell, R

    2008-09-02

    The innovative research conducted for this project contributed greatly to the understanding of generating low-cost hydrogen from solar energy. The project’s research identified two highly leveraging and complementary pathways. The first pathway is to dramatically increase the efficiency of converting sunlight into electricity. Improving solar electric conversion efficiency directly increases hydrogen production. This project produced a world record efficiency for silicon solar cells and contributed to another world record efficiency for a solar concentrator module using multijunction solar cells. The project’s literature review identified a second pathway in which wasted heat from the solar concentration process augments the electrolysis process generating hydrogen. One way to do this is to use a “heat mirror” that reflects the heat-producing infrared and transmits the visible spectrum to the solar cells; this also increases solar cell conversion efficiency. An economic analysis of this concept confirms that, if long-term concentrator photovoltaic (CPV) and solid-oxide electrolyzer cost goals can be achieved, hydrogen will be produced from solar energy cheaper than the cost of gasoline. The potential public benefits from this project are significant. The project has identified a potential energy source for the nation’s future electricity and transportation needs that is entirely “home grown” and carbon free. As CPV enter the nation’s utility markets, the opportunity for this approach to be successful is greatly increased. Amonix strongly recommends further exploration of this project’s findings.

  6. Nuclear emergency preparedness. Final report of the Nordic nuclear safety research project BOK-1

    Energy Technology Data Exchange (ETDEWEB)

    Lauritzen, Bent [Risoe National Lab., Roskilde (Denmark)

    2002-02-01

    Final report of the Nordic Nuclear Safety Research project BOK-1. The BOK-1 project, 'Nuclear Emergency Preparedness', was carried out in 1998-2001 with participants from the Nordic and Baltic Sea regions. The project consists of six sub-projects: Laboratory measurements and quality assurance (BOK-1.1); Mobile measurements and measurement strategies (BOK-1.2); Field measurement and data assimilation (BOK-1.3); Countermeasures in agriculture and forestry (BOK-1.4); Emergency monitoring in the Nordic and Baltic Sea countries (BOK-1.5); and Nuclear exercises (BOK-1.6). For each sub-project, the project outline, objectives and organization are described and main results presented. (au)

  7. Nuclear emergency preparedness. Final report of the Nordic nuclear safety research project BOK-1

    International Nuclear Information System (INIS)

    Lauritzen, Bent

    2002-02-01

    Final report of the Nordic Nuclear Safety Research project BOK-1. The BOK-1 project, 'Nuclear Emergency Preparedness', was carried out in 1998-2001 with participants from the Nordic and Baltic Sea regions. The project consists of six sub-projects: Laboratory measurements and quality assurance (BOK-1.1); Mobile measurements and measurement strategies (BOK-1.2); Field measurement and data assimilation (BOK-1.3); Countermeasures in agriculture and forestry (BOK-1.4); Emergency monitoring in the Nordic and Baltic Sea countries (BOK-1.5); and Nuclear exercises (BOK-1.6). For each sub-project, the project outline, objectives and organization are described and main results presented. (au)

  8. Sequence Analysis and Characterization of Active Human Alu Subfamilies Based on the 1000 Genomes Pilot Project.

    Science.gov (United States)

    Konkel, Miriam K; Walker, Jerilyn A; Hotard, Ashley B; Ranck, Megan C; Fontenot, Catherine C; Storer, Jessica; Stewart, Chip; Marth, Gabor T; Batzer, Mark A

    2015-08-29

    The goal of the 1000 Genomes Consortium is to characterize human genome structural variation (SV), including forms of copy number variations such as deletions, duplications, and insertions. Mobile element insertions, particularly Alu elements, are major contributors to genomic SV among humans. During the pilot phase of the project we experimentally validated 645 (611 intergenic and 34 exon targeted) polymorphic "young" Alu insertion events, absent from the human reference genome. Here, we report high resolution sequencing of 343 (322 unique) recent Alu insertion events, along with their respective target site duplications, precise genomic breakpoint coordinates, subfamily assignment, percent divergence, and estimated A-rich tail lengths. All the sequenced Alu loci were derived from the AluY lineage with no evidence of retrotransposition activity involving older Alu families (e.g., AluJ and AluS). AluYa5 is currently the most active Alu subfamily in the human lineage, followed by AluYb8, and many others including three newly identified subfamilies we have termed AluYb7a3, AluYb8b1, and AluYa4a1. This report provides the structural details of 322 unique Alu variants from individual human genomes collectively adding about 100 kb of genomic variation. Many Alu subfamilies are currently active in human populations, including a surprising level of AluY retrotransposition. Human Alu subfamilies exhibit continuous evolution with potential drivers sprouting new Alu lineages. © The Author(s) 2015. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.

  9. Perspectives from the Avian Phylogenomics Project: Questions that Can Be Answered with Sequencing All Genomes of a Vertebrate Class.

    Science.gov (United States)

    Jarvis, Erich D

    2016-01-01

    The rapid pace of advances in genome technology, with concomitant reductions in cost, makes it feasible that one day in our lifetime we will have available extant genomes of entire classes of species, including vertebrates. I recently helped cocoordinate the large-scale Avian Phylogenomics Project, which collected and sequenced genomes of 48 bird species representing most currently classified orders to address a range of questions in phylogenomics and comparative genomics. The consortium was able to answer questions not previously possible with just a few genomes. This success spurred on the creation of a project to sequence the genomes of at least one individual of all extant ∼10,500 bird species. The initiation of this project has led us to consider what questions now impossible to answer could be answered with all genomes, and could drive new questions now unimaginable. These include the generation of a highly resolved family tree of extant species, genome-wide association studies across species to identify genetic substrates of many complex traits, redefinition of species and the species concept, reconstruction of the genomes of common ancestors, and generation of new computational tools to address these questions. Here I present visions for the future by posing and answering questions regarding what scientists could potentially do with available genomes of an entire vertebrate class.

  10. 'Advancement of KHPS to DOE TRL 7/8' Project - Final Technical Report

    Energy Technology Data Exchange (ETDEWEB)

    Adonizio, Mary Ann [Verdant Power Inc., New York, NY (United States); Corren, Dean [Verdant Power Inc., New York, NY (United States); Smith, Ron [Verdant Power Inc., New York, NY (United States); Colby, Jonathan [Verdant Power Inc., New York, NY (United States); Hernandez, Aaron [Verdant Power Inc., New York, NY (United States)

    2016-04-08

    Final Report describing activities performed under the 'Advancement of the KHPS to DOE TRL 7/8' project, including the development of critical component test protocols, testing and analysis of the Gen5 KHPS main shaft seal, and continuing compliance work on approved operational environmental monitoring plans in anticipation of KHPS turbine installation at Verdant Power's Roosevelt Island Tidal Energy (RITE) Project site in New York, NY.

  11. Field of genes: the politics of science and identity in the Estonian Genome Project.

    Science.gov (United States)

    Fletcher, Amy L

    2004-04-01

    This case study of the Estonian Genome Project (EGP) analyses the Estonian policy decision to construct a national human gene bank. Drawing upon qualitative data from newspaper articles and public policy documents, it focuses on how proponents use discourse to link the EGP to the broader political goal of securing Estonia's position within the Western/European scientific and cultural space. This dominant narrative is then situated within the analytical notion of the "brand state", which raises potentially negative political consequences for this type of market-driven genomic research. Considered against the increasing number of countries engaging in gene bank and/or gene database projects, this analysis of Estonia elucidates issues that cross national boundaries, while also illuminating factors specific to this small, post-Soviet state as it enters the global biocybernetic economy.

  12. Demonstration Project 111, ITS/CVO Technology Truck, Final Project Report

    Energy Technology Data Exchange (ETDEWEB)

    Gambrell, KP

    2002-01-11

    In 1995, the planning and building processes began to design and develop a mobile demonstration unit that could travel across the nation and be used as an effective outreach tool. In 1997, the unit was completed; and from June 1997 until December 2000, the Federal Highway Administration (FHWA)/Federal Motor Carrier Safety Administration (FMCSA) mobilized the Technology Truck, also known as Demonstration Project No. 111, ''Advanced Motor Carrier Operations and Safety Technologies.'' The project featured the latest available state-of-the-practice intelligent transportation systems (ITS) technologies designed to improve both the efficiency and safety of commercial vehicle operations (CVO). The Technology Truck was designed to inform and educate the motor carrier community and other stakeholders regarding ITS technologies, thus gaining support and buy-in for participation in the ITS program. The primary objective of the project was to demonstrate new and emerging ITS/CVO technologies and programs, showing their impact on motor carrier safety and productivity. In order to meet the objectives of the Technology Truck project, the FHWA/FMCSA formed public/private partnerships with industry and with Oak Ridge National Laboratory to demonstrate and display available ITS/CVO technologies in a cooperative effort. The mobile demonstration unit was showcased at national and regional conferences, symposiums, universities, truck shows and other venues, in an effort to reach as many potential users and decision makers as possible. By the end of the touring phase, the ITS/CVO Technology Truck had been demonstrated in 38 states, 4 Canadian provinces, 88 cities, and 114 events; been toured by 18,099 people; and traveled 115,233 miles. The market penetration for the Technology Truck exceeded 4,000,000, and the website received more than 25,000 hits. In addition to the Truck's visits, the portable ITS/CVO kiosk was demonstrated at 31 events in 23 cites in 15

  13. The MedSeq Project: a randomized trial of integrating whole genome sequencing into clinical medicine.

    Science.gov (United States)

    Vassy, Jason L; Lautenbach, Denise M; McLaughlin, Heather M; Kong, Sek Won; Christensen, Kurt D; Krier, Joel; Kohane, Isaac S; Feuerman, Lindsay Z; Blumenthal-Barby, Jennifer; Roberts, J Scott; Lehmann, Lisa Soleymani; Ho, Carolyn Y; Ubel, Peter A; MacRae, Calum A; Seidman, Christine E; Murray, Michael F; McGuire, Amy L; Rehm, Heidi L; Green, Robert C

    2014-03-20

    Whole genome sequencing (WGS) is already being used in certain clinical and research settings, but its impact on patient well-being, health-care utilization, and clinical decision-making remains largely unstudied. It is also unknown how best to communicate sequencing results to physicians and patients to improve health. We describe the design of the MedSeq Project: the first randomized trials of WGS in clinical care. This pair of randomized controlled trials compares WGS to standard of care in two clinical contexts: (a) disease-specific genomic medicine in a cardiomyopathy clinic and (b) general genomic medicine in primary care. We are recruiting 8 to 12 cardiologists, 8 to 12 primary care physicians, and approximately 200 of their patients. Patient participants in both the cardiology and primary care trials are randomly assigned to receive a family history assessment with or without WGS. Our laboratory delivers a genome report to physician participants that balances the needs to enhance understandability of genomic information and to convey its complexity. We provide an educational curriculum for physician participants and offer them a hotline to genetics professionals for guidance in interpreting and managing their patients' genome reports. Using varied data sources, including surveys, semi-structured interviews, and review of clinical data, we measure the attitudes, behaviors and outcomes of physician and patient participants at multiple time points before and after the disclosure of these results. The impact of emerging sequencing technologies on patient care is unclear. We have designed a process of interpreting WGS results and delivering them to physicians in a way that anticipates how we envision genomic medicine will evolve in the near future. That is, our WGS report provides clinically relevant information while communicating the complexity and uncertainty of WGS results to physicians and, through physicians, to their patients. This project will not only

  14. Advanced Flue Gas Desulfurization (AFGD) demonstration project: Volume 2, Project performance and economics. Final technical report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-04-30

    The project objective is to demonstrate removal of 90--95% or more of the SO{sub 2} at approximately one-half the cost of conventional scrubbing technology; and to demonstrate significant reduction of space requirements. In this project, Pure Air has built a single SO{sub 2} absorber for a 528-MWe power plant. The absorber performs three functions in a single vessel: prequencher, absorber, and oxidation of sludge to gypsum. Additionally, the absorber is of a co- current design, in which the flue gas and scrubbing slurry move in the same direction and at a relatively high velocity compared to conventional scrubbers. These features all combine to yield a state- of-the-art SO{sub 2} absorber that is more compact and less expensive than conventional scrubbers. The project incorporated a number of technical features including the injection of pulverized limestone directly into the absorber, a device called an air rotary sparger located within the base of the absorber, and a novel wastewater evaporation system. The air rotary sparger combines the functions of agitation and air distribution into one piece of equipment to facilitate the oxidation of calcium sulfite to gypsum. Additionally, wastewater treatment is being demonstrated to minimize water disposal problems inherent in many high-chloride coals. Bituminous coals primarily from the Indiana, Illinois coal basin containing 2--4.5% sulfur were tested during the demonstration. The Advanced Flue Gas Desulfurization (AFGD) process has demonstrated removal of 95% or more of the SO{sub 2} while providing a commercial gypsum by-product in lieu of solid waste. A portion of the commercial gypsum is being agglomerated into a product known as PowerChip{reg_sign} gypsum which exhibits improved physical properties, easier flowability and more user friendly handling characteristics to enhance its transportation and marketability to gypsum end-users.

  15. Technical assistance for Meharry Medical College Energy Efficiency Project. Final project status and technical report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-05-08

    This report presents the results of a program to provide technical assistance to Meharry Medical College. The purpose of the program is to facilitate Meharry`s effort to finance a campus-wide facility retrofit. The US Department of Energy (USDOE) funded the program through a grant to the Tennessee Department of Economic and Community Development (TECD). The University of Memphis-Technology and Energy Services (UM-TES), under contract to TECD, performed program services. The report has three sections: (1) introduction; (2) project definition, financing, and participants; and (3) opportunities for federal participation.

  16. Agency for Nuclear Projects/Nuclear Waste Project Office final progress report

    International Nuclear Information System (INIS)

    1992-01-01

    The Nevada Agency for Nuclear Projects/Nuclear Waste Project Office (NWPO) was formally established by Executive Policy in 1983 following passage of the federal Nuclear Waste Policy Act of 1982 (Act). That Act provides for the systematic siting, construction, operation, and closure of high-level radioactive defense and research by-products and other forms of high-level radioactive waste from around the country which will be stored at such repositories. In 1985 the Nevada legislature formally established the NWPO as a distinct and statutorily authorized agency to provide support to the Governor and State Legislature on matters concerning the high-level nuclear waste programs. The NWPO utilized a small, central staff supplemented by contractual services for needed technical and specialized expertise in order to provide high quality oversight and monitoring of federal activities, to conduct necessary independent studies, and to avoid unnecessary duplication of efforts. This report summarizes the results of this ongoing program to ensure that risks to the environment and to human safety are minimized. It includes findings in the areas of hydrogeology, geology, quality assurance activities, repository engineering, legislature participation, socioeconomic affects, risk assessments, monitoring programs, public information dissemination, and transportation activities. The bulk of the reporting deals with the Yucca Mountain facility

  17. LIFAC sorbent injection desulfurization demonstration project. Final report, volume II: Project performance and economics

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-01-01

    This publication discusses the demonstration of the LIFAC sorbent injection technology at Richmond Power and Light`s Whitewater Valley Unit No. 2, performed under the auspices of the U.S. Department of Energy`s (DOE) Clean Coal Technology Program. LIFAC is a sorbent injection technology capable of removing 75 to 85 percent of a power plant`s SO{sub 2} emissions using limestone at calcium to sulfur molar ratios of between 2 and 2.5 to 1. The site of the demonstration is a coal-fired electric utility power plant located in Richmond, Indiana. The project is being conducted by LIFAC North America (LIFAC NA), a joint venture partnership of Tampella Power Corporation and ICF Kaiser Engineers, in cooperation with DOE, RP&L, and Research Institute (EPRI), the State of Indiana, and Black Beauty Coal Company. The purpose of Public Design Report Volume 2: Project Performance and Economics is to consolidate, for public use, the technical efficiency and economy of the LIFAC Process. The report has been prepared pursuant to the Cooperative Agreement No. DE-FC22-90PC90548 between LIFAC NA and the U.S. Department of Energy.

  18. Phase V storage (Project W-112) Central Waste Complex operational readiness review, final report

    International Nuclear Information System (INIS)

    Wight, R.H.

    1997-01-01

    This document is the final report for the RFSH conducted, Contractor Operational Readiness Review (ORR) for the Central Waste Complex (CWC) Project W-112 and Interim Safety Basis implementation. As appendices, all findings, observations, lines of inquiry and the implementation plan are included

  19. Parent Attitudes Toward the Virginia Beach Year-Round School Pilot Project. Final Report.

    Science.gov (United States)

    Schlechty, Phillip C.

    Part of the Virginia Beach year-round school program evaluation, this final report contains a detailed analysis of parental attitudes, beliefs, and perceptions. The data leads to the following conclusions: a majority (53.3 percent) of parents are dubious or negative toward the 45-15 pilot project; a slight majority of parents in the pilot schools…

  20. The Final Year Project (FYP) in Social Sciences: Establishment of Its Associated Competences and Evaluation Standards

    Science.gov (United States)

    Mateo, Joan; Escofet, Anna; Martinez, Francesc; Ventura, Javier; Vlachopoulos, Dimitrios

    2012-01-01

    This paper presents the fundamental characteristics of the Final Year Project (FYP), its associated competences and some evaluation standards that derived from a research conducted by the regional government of Catalonia (Spain) and the Catalan University Quality Assurance Agency. More analytically, the paper begins with the definition of the…

  1. 77 FR 23740 - Sears Point Wetland and Watershed Restoration Project, Sonoma County, CA; Final Environmental...

    Science.gov (United States)

    2012-04-20

    ...-FF08RSFC00] Sears Point Wetland and Watershed Restoration Project, Sonoma County, CA; Final Environmental... environmental impact report and environmental impact statement (EIR/EIS) for the Sears Point Wetland and..., while providing public access and recreational and educational opportunities compatible with ecological...

  2. Phase 5 storage (Project W-112) Central Waste Complex operational readiness review, final report

    Energy Technology Data Exchange (ETDEWEB)

    Wight, R.H.

    1997-05-30

    This document is the final report for the RFSH conducted, Contractor Operational Readiness Review (ORR) for the Central Waste Complex (CWC) Project W-112 and Interim Safety Basis implementation. As appendices, all findings, observations, lines of inquiry and the implementation plan are included.

  3. Analysis of final year DVM research projects submitted to the Faculty ...

    African Journals Online (AJOL)

    Central Research Laboratory

    in the library. The essence of this study is to guide prospective final year students and researchers in the choice of research topics as this will help in saving their time. It will also ... and Undergraduate projects of the same department in 2002. Obajemu (1999) also .... majority of the rural people. The distribution by animal ...

  4. Final audit report of remedial action construction at the UMTRA project site Rifle, Colorado. Rev. 1

    International Nuclear Information System (INIS)

    1997-01-01

    This final audit report summarizes the assessments performed by the U.S. Department of Energy (DOE) Environmental Restoration Division (ERD) and its Technical Assistance Contractor (TAC) of remedial action compliance with approved plans, specifications, standards, and 40 CFR Part 192 at the Rifle, Colorado, Uranium Mill Tailings Remedial Action (UMTRA) Project site. Remedial action construction was directed by the Remedial Action Contractor (RAC)

  5. 76 FR 12096 - McCloud-Pit Project; Notice of Availability of the Final Environmental Impact Statement for the...

    Science.gov (United States)

    2011-03-04

    ... Project; Notice of Availability of the Final Environmental Impact Statement for the Mccloud-Pit... Pit Rivers in Shasta County, California and has prepared a final environmental impact statement (EIS... and the alternatives for relicensing the McCloud-Pit Project. The final EIS documents the views of...

  6. 78 FR 45268 - Notice of Availability of the San Diego Gas & Electric Ocotillo Sol Solar Project Final...

    Science.gov (United States)

    2013-07-26

    ...] Notice of Availability of the San Diego Gas & Electric Ocotillo Sol Solar Project Final Environmental...) Ocotillo Sol Solar Project in Imperial County, California, and by this notice is announcing its... Ocotillo Sol Solar Project Final EIS/Proposed CDCA Plan Amendment have been sent to affected Federal, State...

  7. Ethical challenges and innovations in the dissemination of genomic data: the experience of the PERSPECTIVE project

    Directory of Open Access Journals (Sweden)

    Lévesque E

    2015-08-01

    Full Text Available Emmanuelle Lévesque,1 Bartha Maria Knoppers,1 Jacques Simard,2 1Department of Human Genetics, Centre for Genomics and Policy, McGill University, Montréal, 2Genomics Centre, CHU de Québec Research Center, Department of Molecular Medicine, Laval University, Québec City, QC, Canada Abstract: The importance of making genomic data available for future research is now widely recognized among the scientific community and policymakers. In this era of shared responsibility for data dissemination, improved patient care through research depends on the development of powerful and secure data-sharing systems. As part of the concerted effort to share research resources, the project entitled Personalized Risk Stratification for Prevention and Early Detection of Breast Cancer (PERSPECTIVE makes effective data sharing through the development of a data-sharing framework, one of its goals. The secondary uses of data from PERSPECTIVE for future research promise to enhance our knowledge of breast cancer etiologies without duplicating data-gathering efforts. Despite its benefit for research, we recognize the ethical challenges of data sharing on the local, national, and international levels. The effective management of ethical approvals for projects spanning across jurisdictions, the return of results to research participants, and research incentives and recognition for data production, are but a few pressing issues that need to be properly addressed. We discuss how we managed these issues and suggest how ongoing innovations might help to facilitate data sharing in future genomic research projects. Keywords: data sharing, research ethics, cancer

  8. The human genome project: Information management, access, and regulation. Technical progress report, 1 April--31 August 1993

    Energy Technology Data Exchange (ETDEWEB)

    McInerney, J.D.; Micikas, L.B.

    1993-09-10

    Efforts are described to prepare educational materials including computer based as well as conventional type teaching materials for training interested high school and elementary students in aspects of Human Genome Project.

  9. Hunting for genes for hypertension: the Millennium Genome Project for Hypertension.

    Science.gov (United States)

    Tabara, Yasuharu; Kohara, Katsuhiko; Miki, Tetsuro

    2012-06-01

    The Millennium Genome Project for Hypertension was started in 2000 to identify genetic variants conferring susceptibility to hypertension, with the aim of furthering the understanding of the pathogenesis of this condition and realizing genome-based personalized medical care. Two different approaches were launched, genome-wide association analysis using single-nucleotide polymorphisms (SNPs) and microsatellite markers, and systematic candidate gene analysis, under the hypothesis that common variants have an important role in the etiology of common diseases. These multilateral approaches identified ATP2B1 as a gene responsible for hypertension in not only Japanese but also Caucasians. The high blood pressure susceptibility conferred by certain alleles of ATP2B1 has been widely replicated in various populations. Ex vivo mRNA expression analysis in umbilical artery smooth muscle cells indicated that reduced expression of this gene associated with the risk allele may be an underlying mechanism relating the ATP2B1 variant to hypertension. However, the effect size of a SNP was too small to clarify the entire picture of the genetic basis of hypertension. Further, dense genome analysis with accurate phenotype data may be required.

  10. Final Project Summary Report Bechtel Nevada and Fiberchem Environmental, Inc., Cooperative Research and Technology Development Project

    Energy Technology Data Exchange (ETDEWEB)

    R. J. Pollina

    1999-04-01

    This is a report summarizing work on a small project dedicated to adapting a new chemical sensing platform for the US Department of Energy and its customers. At the same time and in the spirit of technology transfer, FCI Environmental, Inc., would receive technical support in the form of expertise from the US Department of Energy to assist in developing this product. The sensor is a hybrid integrated-circuit, optical waveguide, chemical sensor that is patented by FCI Environmental, Inc., and manufactured under license by Texas Instruments, Inc. A down-hole penetrometer probe was designed for use in hot, 60 C, hydrocarbon-saturated, saline environment at a depth of 200 feet. The probe design includes three chemical sensing, hybrid integrated-circuits with chemical reference and measurement channels, a water seal, output electronics, and a removable measurement head for replacement in the field. A hand-held chemical detector prototype--containing a hybrid integrated-circuit chemical sensor with reference channel, user alarm, and level display--was designed and constructed, and a software interface developed to operate the hand-held sensor interfaced with a laboratory data acquisition system.

  11. Grand Junction Projects Office Remedial Action Project Building 2 public dose evaluation. Final report

    International Nuclear Information System (INIS)

    Morris, R.

    1996-05-01

    Building 2 on the U.S. Department of Energy (DOE) Grand Junction Projects Office (GJPO) site, which is operated by Rust Geotech, is part of the GJPO Remedial Action Program. This report describes measurements and modeling efforts to evaluate the radiation dose to members of the public who might someday occupy or tear down Building 2. The assessment of future doses to those occupying or demolishing Building 2 is based on assumptions about future uses of the building, measured data when available, and predictive modeling when necessary. Future use of the building is likely to be as an office facility. The DOE sponsored program, RESRAD-BUILD, Version. 1.5 was chosen for the modeling tool. Releasing the building for unrestricted use instead of demolishing it now could save a substantial amount of money compared with the baseline cost estimate because the site telecommunications system, housed in Building 2, would not be disabled and replaced. The information developed in this analysis may be used as part of an as low as reasonably achievable (ALARA) cost/benefit determination regarding disposition of Building 2

  12. Final disposal of radioactive wastes in Switzerland: concept and overview of Project Guarantee 1985

    International Nuclear Information System (INIS)

    Anon.

    1985-01-01

    The validity of the operational licences of the existing Swiss nuclear power plants (NPP) Beznau I and II, Muehleberg, Goesgen and Leibstadt after 31st. December 1985 is, because of official requirements, dependent on the demonstration of permanent, safe management and final disposal of radioactive waste. For this purpose, the NPP companies have to prepare a so-called guarantee project and present this to the Bundesrat for review. The appropriate investigations and research have been carried out by Nagra (National Cooperative for the Storage of Radioactive Waste). The 1985 Project Gewaehr (Guarantee) is described in an eight volume report NGB 85-01 to 85-08 and individual research projects are reported on in separate NTB-series reference reports. The present volume NGB 85-01 takes the form of a self-contained project overview in which the concepts for nuclear waste management are described, the contents of the remaining volumes NGB 85-02 to 85-08 are summarized and Project conclusions are drawn from Project Gewaehr 1985. Project Gewaehr 1985 covers two repository types: Type C repository for high-level and certain alpha-containing intermediate-level waste, and Type B repository for all remaining intermediate- and low-level waste. The Project shows in detail that technical feasibility of final disposal can be assumed given presently available methods, that the technical safety barriers show a high level of efficiency and that suitable geological options are available to ensure long-term safety in Switzerland as the concept is defined by official requirements. The Project safety analyses show that the chosen disposal concepts assure the protection of mankind and the environment under all realistically anticipated conditions

  13. Characterization of apparently balanced chromosomal rearrangements from the developmental genome anatomy project.

    Science.gov (United States)

    Higgins, Anne W; Alkuraya, Fowzan S; Bosco, Amy F; Brown, Kerry K; Bruns, Gail A P; Donovan, Diana J; Eisenman, Robert; Fan, Yanli; Farra, Chantal G; Ferguson, Heather L; Gusella, James F; Harris, David J; Herrick, Steven R; Kelly, Chantal; Kim, Hyung-Goo; Kishikawa, Shotaro; Korf, Bruce R; Kulkarni, Shashikant; Lally, Eric; Leach, Natalia T; Lemyre, Emma; Lewis, Janine; Ligon, Azra H; Lu, Weining; Maas, Richard L; MacDonald, Marcy E; Moore, Steven D P; Peters, Roxanna E; Quade, Bradley J; Quintero-Rivera, Fabiola; Saadi, Irfan; Shen, Yiping; Shendure, Jay; Williamson, Robin E; Morton, Cynthia C

    2008-03-01

    Apparently balanced chromosomal rearrangements in individuals with major congenital anomalies represent natural experiments of gene disruption and dysregulation. These individuals can be studied to identify novel genes critical in human development and to annotate further the function of known genes. Identification and characterization of these genes is the goal of the Developmental Genome Anatomy Project (DGAP). DGAP is a multidisciplinary effort that leverages the recent advances resulting from the Human Genome Project to increase our understanding of birth defects and the process of human development. Clinically significant phenotypes of individuals enrolled in DGAP are varied and, in most cases, involve multiple organ systems. Study of these individuals' chromosomal rearrangements has resulted in the mapping of 77 breakpoints from 40 chromosomal rearrangements by FISH with BACs and fosmids, array CGH, Southern-blot hybridization, MLPA, RT-PCR, and suppression PCR. Eighteen chromosomal breakpoints have been cloned and sequenced. Unsuspected genomic imbalances and cryptic rearrangements were detected, but less frequently than has been reported previously. Chromosomal rearrangements, both balanced and unbalanced, in individuals with multiple congenital anomalies continue to be a valuable resource for gene discovery and annotation.

  14. Radiological and environmental consequences. Final report of the Nordic Nuclear Safety Research project BOK-2

    International Nuclear Information System (INIS)

    Palsson, S.E.

    2002-11-01

    Final report of the Nordic Nuclear Safety Research project BOK-2, Radiological and Environmental Consequences. The project was carried out 1998-2001 with participants from all the Nordic countries. Representatives from the Baltic States were also invited to some of the meetings and seminars. The project consisted of work on terrestrial and marine radioecology and had a broad scope in order to enable participation of research groups with various fields of interest. This report focuses on the project itself and gives a general summary of the studies undertaken. A separate technical report summarises the work done by each research group and gives references to papers published in scientific journals. The topics in BOK-2 included improving assessment of old and recent fallout, use of radionuclides as tracers in Nordic marine areas, improving assessment of internal doses and use of mass spectrometry in radioecology. (au)

  15. Next Generation Nuclear Plant (NGNP) Prismatic HTGR Conceptual Design Project - Final Technical Report

    Energy Technology Data Exchange (ETDEWEB)

    Saurwein, John

    2011-07-15

    This report is the Final Technical Report for the Next Generation Nuclear Plant (NGNP) Prismatic HTGR Conceptual Design Project conducted by a team led by General Atomics under DOE Award DE-NE0000245. The primary overall objective of the project was to develop and document a conceptual design for the Steam Cycle Modular Helium Reactor (SC-MHR), which is the reactor concept proposed by General Atomics for the NGNP Demonstration Plant. The report summarizes the project activities over the entire funding period, compares the accomplishments with the goals and objectives of the project, and discusses the benefits of the work. The report provides complete listings of the products developed under the award and the key documents delivered to the DOE.

  16. Next Generation Nuclear Plant (NGNP) Prismatic HTGR Conceptual Design Project - Final Technical Report

    International Nuclear Information System (INIS)

    Saurwein, J.

    2011-01-01

    This report is the Final Technical Report for the Next Generation Nuclear Plant (NGNP) Prismatic HTGR Conceptual Design Project conducted by a team led by General Atomics under DOE Award DE-NE0000245. The primary overall objective of the project was to develop and document a conceptual design for the Steam Cycle Modular Helium Reactor (SC-MHR), which is the reactor concept proposed by General Atomics for the NGNP Demonstration Plant. The report summarizes the project activities over the entire funding period, compares the accomplishments with the goals and objectives of the project, and discusses the benefits of the work. The report provides complete listings of the products developed under the award and the key documents delivered to the DOE.

  17. The Genomes OnLine Database (GOLD) v.5: a metadata management system based on a four level (meta)genome project classification

    Science.gov (United States)

    Reddy, T.B.K.; Thomas, Alex D.; Stamatis, Dimitri; Bertsch, Jon; Isbandi, Michelle; Jansson, Jakob; Mallajosyula, Jyothi; Pagani, Ioanna; Lobos, Elizabeth A.; Kyrpides, Nikos C.

    2015-01-01

    The Genomes OnLine Database (GOLD; http://www.genomesonline.org) is a comprehensive online resource to catalog and monitor genetic studies worldwide. GOLD provides up-to-date status on complete and ongoing sequencing projects along with a broad array of curated metadata. Here we report version 5 (v.5) of the database. The newly designed database schema and web user interface supports several new features including the implementation of a four level (meta)genome project classification system and a simplified intuitive web interface to access reports and launch search tools. The database currently hosts information for about 19 200 studies, 56 000 Biosamples, 56 000 sequencing projects and 39 400 analysis projects. More than just a catalog of worldwide genome projects, GOLD is a manually curated, quality-controlled metadata warehouse. The problems encountered in integrating disparate and varying quality data into GOLD are briefly highlighted. GOLD fully supports and follows the Genomic Standards Consortium (GSC) Minimum Information standards. PMID:25348402

  18. The Genomes OnLine Database (GOLD) v.5: a metadata management system based on a four level (meta)genome project classification

    Energy Technology Data Exchange (ETDEWEB)

    Reddy, Tatiparthi B. K. [USDOE Joint Genome Institute (JGI), Walnut Creek, CA (United States); Thomas, Alex D. [USDOE Joint Genome Institute (JGI), Walnut Creek, CA (United States); Stamatis, Dimitri [USDOE Joint Genome Institute (JGI), Walnut Creek, CA (United States); Bertsch, Jon [USDOE Joint Genome Institute (JGI), Walnut Creek, CA (United States); Isbandi, Michelle [USDOE Joint Genome Institute (JGI), Walnut Creek, CA (United States); Jansson, Jakob [USDOE Joint Genome Institute (JGI), Walnut Creek, CA (United States); Mallajosyula, Jyothi [USDOE Joint Genome Institute (JGI), Walnut Creek, CA (United States); Pagani, Ioanna [USDOE Joint Genome Institute (JGI), Walnut Creek, CA (United States); Lobos, Elizabeth A. [USDOE Joint Genome Institute (JGI), Walnut Creek, CA (United States); Kyrpides, Nikos C. [USDOE Joint Genome Institute (JGI), Walnut Creek, CA (United States); King Abdulaziz Univ., Jeddah (Saudi Arabia)

    2014-10-27

    The Genomes OnLine Database (GOLD; http://www.genomesonline.org) is a comprehensive online resource to catalog and monitor genetic studies worldwide. GOLD provides up-to-date status on complete and ongoing sequencing projects along with a broad array of curated metadata. Within this paper, we report version 5 (v.5) of the database. The newly designed database schema and web user interface supports several new features including the implementation of a four level (meta)genome project classification system and a simplified intuitive web interface to access reports and launch search tools. The database currently hosts information for about 19 200 studies, 56 000 Biosamples, 56 000 sequencing projects and 39 400 analysis projects. More than just a catalog of worldwide genome projects, GOLD is a manually curated, quality-controlled metadata warehouse. The problems encountered in integrating disparate and varying quality data into GOLD are briefly highlighted. Lastly, GOLD fully supports and follows the Genomic Standards Consortium (GSC) Minimum Information standards.

  19. Final Report for the ADMX Phase 2a Project at the University of Washington

    International Nuclear Information System (INIS)

    Rosenberg, Leslie J.

    2015-01-01

    This is a final report of the ADMX (Axion Dark Matter eXperiment) Phase 2a program. This program is a project allowing for a sensitive axion dark-matter search at higher axion masses. The Phase 2a program also prepares the project for lower temperature anticipated in later operations. The Phase 2a program includes sensitive data-taking operations at two cavity modes, TM010 and TM020, allowing for faster data-taking operations and extending the search to higher and plausible dark-matter axion masses.

  20. Human genome libraries. Final progress report, February 1, 1994--August 31, 1997

    Energy Technology Data Exchange (ETDEWEB)

    Kao, Fa-Ten

    1998-01-01

    The goal of this program is to use a novel technology of chromosome microdissection and microcloning to construct chromosome region-specific libraries as resources for various human genome program studies. Region specific libraries have been constructed for the entire human chromosomes 2 and 18.

  1. Cloning, production, and purification of proteins for a medium-scale structural genomics project.

    Science.gov (United States)

    Quevillon-Cheruel, Sophie; Collinet, Bruno; Trésaugues, Lionel; Minard, Philippe; Henckes, Gilles; Aufrère, Robert; Blondeau, Karine; Zhou, Cong-Zhao; Liger, Dominique; Bettache, Nabila; Poupon, Anne; Aboulfath, Ilham; Leulliot, Nicolas; Janin, Joël; van Tilbeurgh, Herman

    2007-01-01

    The South-Paris Yeast Structural Genomics Pilot Project (http://www.genomics.eu.org) aims at systematically expressing, purifying, and determining the three-dimensional structures of Saccharomyces cerevisiae proteins. We have already cloned 240 yeast open reading frames in the Escherichia coli pET system. Eighty-two percent of the targets can be expressed in E. coli, and 61% yield soluble protein. We have currently purified 58 proteins. Twelve X-ray structures have been solved, six are in progress, and six other proteins gave crystals. In this chapter, we present the general experimental flowchart applied for this project. One of the main difficulties encountered in this pilot project was the low solubility of a great number of target proteins. We have developed parallel strategies to recover these proteins from inclusion bodies, including refolding, coexpression with chaperones, and an in vitro expression system. A limited proteolysis protocol, developed to localize flexible regions in proteins that could hinder crystallization, is also described.

  2. Genome3D: a UK collaborative project to annotate genomic sequences with predicted 3D structures based on SCOP and CATH domains.

    Science.gov (United States)

    Lewis, Tony E; Sillitoe, Ian; Andreeva, Antonina; Blundell, Tom L; Buchan, Daniel W A; Chothia, Cyrus; Cuff, Alison; Dana, Jose M; Filippis, Ioannis; Gough, Julian; Hunter, Sarah; Jones, David T; Kelley, Lawrence A; Kleywegt, Gerard J; Minneci, Federico; Mitchell, Alex; Murzin, Alexey G; Ochoa-Montaño, Bernardo; Rackham, Owen J L; Smith, James; Sternberg, Michael J E; Velankar, Sameer; Yeats, Corin; Orengo, Christine

    2013-01-01

    Genome3D, available at http://www.genome3d.eu, is a new collaborative project that integrates UK-based structural resources to provide a unique perspective on sequence-structure-function relationships. Leading structure prediction resources (DomSerf, FUGUE, Gene3D, pDomTHREADER, Phyre and SUPERFAMILY) provide annotations for UniProt sequences to indicate the locations of structural domains (structural annotations) and their 3D structures (structural models). Structural annotations and 3D model predictions are currently available for three model genomes (Homo sapiens, E. coli and baker's yeast), and the project will extend to other genomes in the near future. As these resources exploit different strategies for predicting structures, the main aim of Genome3D is to enable comparisons between all the resources so that biologists can see where predictions agree and are therefore more trusted. Furthermore, as these methods differ in whether they build their predictions using CATH or SCOP, Genome3D also contains the first official mapping between these two databases. This has identified pairs of similar superfamilies from the two resources at various degrees of consensus (532 bronze pairs, 527 silver pairs and 370 gold pairs).

  3. Genomes

    National Research Council Canada - National Science Library

    Brown, T. A. (Terence A.)

    2002-01-01

    ... of genome expression and replication processes, and transcriptomics and proteomics. This text is richly illustrated with clear, easy-to-follow, full color diagrams, which are downloadable from the book's website...

  4. DE-NE0000735 - FINAL REPORT ON THORIUM FUEL CYCLE NEUP PROJECT

    Energy Technology Data Exchange (ETDEWEB)

    Krahn, Steven [Vanderbilt Univ., Nashville, TN (United States); Ault, Timothy [Vanderbilt Univ., Nashville, TN (United States); Worrall, Andrew [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2017-09-30

    The report is broken into six chapters, including this executive summary chapter. Following an introduction, this report discusses each of the project’s three major components (Fuel Cycle Data Package (FCDP) Development, Thorium Fuel Cycle Literature Analysis and Database Development, and the Thorium Fuel Cycle Technical Track and Proceedings). A final chapter is devoted to summarization. Various outcomes, publications, etc. originating from this project can be found in the Appendices at the end of the document.

  5. Final report on Paradox Basin/Gulf Interior: Regulatory project management

    International Nuclear Information System (INIS)

    1986-12-01

    This final report on the Regulatory Project Manager (RPM) program begins with a discussion of the key products produced during the 9-year effort and then focuses on the work performed in the major disciplines. The report then discusses the management of the work effort and the Quality Assurance (QA) program. It concludes with a brief discussion of the records turned over to the Office of Nuclear Waste Isolation (ONWI) at the conclusion of the work. 14 figs., 14 tabs

  6. Final hazard classification and auditable safety analysis for the 105-C Reactor Interim Safe Storage Project

    International Nuclear Information System (INIS)

    Rodovsky, T.J.; Larson, A.R.; Dexheimer, D.

    1996-12-01

    This document summarizes the inventories of radioactive and hazardous materials present in the 105-C Reactor Facility and the operations associated with the Interim Safe Storage Project which includes decontamination and demolition and interim safe storage of the remaining facility. This document also establishes a final hazard classification and verifies that appropriate and adequate safety functions and controls are in place to reduce or mitigate the risk associated with those operations

  7. Consortium biology in immunology: the perspective from the Immunological Genome Project.

    Science.gov (United States)

    Benoist, Christophe; Lanier, Lewis; Merad, Miriam; Mathis, Diane

    2012-10-01

    Although the field has a long collaborative tradition, immunology has made less use than genetics of 'consortium biology', wherein groups of investigators together tackle large integrated questions or problems. However, immunology is naturally suited to large-scale integrative and systems-level approaches, owing to the multicellular and adaptive nature of the cells it encompasses. Here, we discuss the value and drawbacks of this organization of research, in the context of the long-running 'big science' debate, and consider the opportunities that may exist for the immunology community. We position this analysis in light of our own experience, both positive and negative, as participants of the Immunological Genome Project.

  8. ELSI Bibliography: Ethical legal and social implications of the Human Genome Project

    Energy Technology Data Exchange (ETDEWEB)

    Yesley, M.S. [comp.

    1993-11-01

    This second edition of the ELSI Bibliography provides a current and comprehensive resource for identifying publications on the major topics related to the ethical, legal and social issues (ELSI) of the Human Genome Project. Since the first edition of the ELSI Bibliography was printed last year, new publications and earlier ones identified by additional searching have doubled our computer database of ELSI publications to over 5600 entries. The second edition of the ELSI Bibliography reflects this growth of the underlying computer database. Researchers should note that an extensive collection of publications in the database is available for public use at the General Law Library of Los Alamos National Laboratory (LANL).

  9. Resource contingency program - Oregon. Final environmental impact statement, Hermiston power project

    International Nuclear Information System (INIS)

    1995-09-01

    The Bonneville Power Administration (BPA) has statutory responsibilities to supply electrical power to its utility, industrial, and other customers in the Pacific Northwest. In 1990, to cover the outer range of potential load growth with new resources, BPA embarked upon the Resource Contingency Program (RCP). Instead of buying or building generating plants now, BPA has purchased options to acquire power later, if and when it is needed. The decision to acquire any of these option energy projects to fulfill statutory supply obligations will be influenced by Federal system load growth, the outcome of BPA's Business Plan, required operational changes in Columbia-Snake River Hydroelectric facilities, and the loss of major generating resources. In September 1993, three option development agreements were signed with three proposed natural gas-fired, combined cycle combustion turbine CT projects near Chehalis and Satsop, Washington, and near Hermiston, Oregon. Together these three projects could supply BPA with 1,090 average megawatts (aMW) of power. Under these agreements, sponsors are obtaining permits and conducting project design work, and BPA is completing this EIS process. In September 1993, BPA published a Notice of Intent to prepare an environmental impact statement (EIS) on these three proposed gas-fired combustion turbine projects and held public scoping meetings in October 1993 at each site. In February 1994, BPA released an Implementation Plan on the proposed scope of the EIS. A draft EIS on the three proposed projects was published in February 1995. The impacts of the Chehalis and Satsop projects located in Washington State will be covered in one EIS document, while the impacts of the Hermiston project located in Oregon are covered in this final EIS document. It is BPA's intent to continue to base the analysis of impacts on the assumption that all three projects may be constructed at some point in the future

  10. Resource Contingency Program - Oregon : Final Environmental Impact Statement, Hermiston Power Project.

    Energy Technology Data Exchange (ETDEWEB)

    United States. Bonneville Power Administration.

    1995-09-01

    The Bonneville Power Administration (BPA) has statutory responsibilities to supply electrical power to its utility, industrial, and other customers in the Pacific Northwest. In 1990, to cover the outer range of potential load growth with new resources, BPA embarked upon the Resource Contingency Program (RCP). Instead of buying or building generating plants now, BPA has purchased options to acquire power later, if and when it is needed. The decision to acquire any of these option energy projects to fulfill statutory supply obligations will be influenced by Federal system load growth, the outcome of BPA`s Business Plan, required operational changes in Columbia-Snake River Hydroelectric facilities, and the loss of major generating resources. In September 1993, three option development agreements were signed with three proposed natural gas-fired, combined cycle combustion turbine CT projects near Chehalis and Satsop, Washington, and near Hermiston, Oregon. Together these three projects could supply BPA with 1,090 average megawatts (aMW) of power. Under these agreements, sponsors are obtaining permits and conducting project design work, and BPA is completing this EIS process. In September 1993, BPA published a Notice of Intent to prepare an environmental impact statement (EIS) on these three proposed gas-fired combustion turbine projects and held public scoping meetings in October 1993 at each site. In February 1994, BPA released an Implementation Plan on the proposed scope of the EIS. A draft EIS on the three proposed projects was published in February 1995. The impacts of the Chehalis and Satsop projects located in Washington State will be covered in one EIS document, while the impacts of the Hermiston project located in Oregon are covered in this final EIS document. It is BPA`s intent to continue to base the analysis of impacts on the assumption that all three projects may be constructed at some point in the future.

  11. Final environmental impact statement Kenetech/PacifiCorp Windpower Project Carbon County, Wyoming

    International Nuclear Information System (INIS)

    1995-08-01

    The Draft and Final Environmental Impact Statements (DEIS and FEIS) assess the environmental consequences of a proposed windpower energy development in Carbon County, Wyoming. This abbreviated FEIS revises and supplements the DEIS for the project and addresses comments expressed for the DEIS. The proposed project entails the erection of approximately 1,390 wind turbine generators and associated facilities (e.g., roads, substations, distribution and communications lines) by KENETECH Windpower, Inc. A 230-kV transmission line would be built by PacifiCorp, Inc. to connect a proposed substation on Foote Creek Rim near Arlington to the Miner's substation near Hanna. The proposed project would use standard procedures as currently employed by other right-of-way projects, plus additional project-specific and site-specific mitigation measures to ensure that project impacts are minimized on all important resources. Impacts to most resources would be negligible to moderate during the life-of-project. Potentially significant impacts from the project include avian mortality; declining avian populations; threatened, endangered, candidate, and/or state sensitive species mortality and/or habitat loss; disturbance to nearby residents due to noise; changes in visual resources; disturbance of important Native American traditional sites; changes in plant community species composition due to snow redistribution; displacement of big game due to windfarm operation; and loss of sage grouse nesting habitat. The proposed project could also have numerous beneficial impacts including increased revenues generated by taxes, increased employment, and benefits derived from using a nonpolluting resource for electric power generation

  12. Zachary-Fort Lauderdale pipeline construction and conversion project: final supplement to final environmental impact statement. Docket No. CP74-192

    Energy Technology Data Exchange (ETDEWEB)

    None

    1980-05-01

    This Final Supplement to the Final Environmental Impact Statement (Final Supplement) evaluates the economic, engineering, and environmental aspects of newly developed alternatives to an abandonment/conversion project proposed by Florida Gas Transmission Company (Florida Gas). It also updates the staff's previous FEIS and studies revisions to the original proposal. Wherever possible, the staff has adopted portions of its previous FEIS in lieu of reprinting portions of that analysis which require no change. 60 references, 8 figures, 35 tables.

  13. FutureGen 2.0 Pipeline and Regional Carbon Capture Storage Project - Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Burger, Chris [Patrick Engineering Inc., Lisle, IL (United States); Wortman, David [Patrick Engineering Inc., Lisle, IL (United States); Brown, Chris [Battelle Memorial Inst., Richland, WA (United States); Hassan, Syed [Gulf Interstate Engineering, Houston, TX (United States); Humphreys, Ken [Futuregen Industrial Alliance, Inc., Washington, D.C. (United States); Willford, Mark [Futuregen Industrial Alliance, Inc., Washington, D.C. (United States)

    2016-03-31

    The U.S. Department of Energy’s (DOE) FutureGen 2.0 Program involves two projects: (1) the Oxy-Combustion Power Plant Project and (2) the CO2 Pipeline and Storage Project. This Final Technical Report is focused on the CO2 Pipeline and Storage Project. The FutureGen 2.0 CO2 Pipeline and Storage Project evolved from an initial siting and project definition effort in Phase I, into the Phase II activity consisting permitting, design development, the acquisition of land rights, facility design, and licensing and regulatory approvals. Phase II also progressed into construction packaging, construction procurement, and targeted early preparatory activities in the field. The CO2 Pipeline and Storage Project accomplishments were significant, and in some cases unprecedented. The engineering, permitting, legal, stakeholder, and commercial learnings substantially advance the nation’s understanding of commercial-scale CO2 storage in deep saline aquifers. Voluminous and significant information was obtained from the drilling and the testing program of the subsurface, and sophisticated modeling was performed that held up to a wide range of scrutiny. All designs progressed to the point of securing construction contracts or comfort letters attesting to successful negotiation of all contract terms and willing execution at the appropriate time all major project elements – pipeline, surface facilities, and subsurface – as well as operations. While the physical installation of the planned facilities did not proceed in part due to insufficient time to complete the project prior to the expiration of federal funding, the project met significant objectives prior to DOE’s closeout decision. Had additional time been available, there were no known, insurmountable obstacles that would have precluded successful construction and operation of the project. Due to the suspension of the project, site restoration activities were developed and the work was accomplished. The site restoration

  14. Puget Sound Tidal Energy In-Water Testing and Development Project Final Technical Report

    Energy Technology Data Exchange (ETDEWEB)

    Collar, Craig W

    2012-11-16

    others. All required permit and license applications were completed and submitted under this award, including a Final License Application for a pilot hydrokinetic license from the Federal Energy Regulatory Commission. The tasks described above have brought the project through all necessary requirements to construct a tidal pilot project in Admiralty Inlet with the exception of final permit and license approvals, and the selection of a general contractor to perform project construction.

  15. Importing statistical measures into Artemis enhances gene identification in the Leishmania genome project

    Directory of Open Access Journals (Sweden)

    McDonagh Paul D

    2003-06-01

    Full Text Available Abstract Background Seattle Biomedical Research Institute (SBRI as part of the Leishmania Genome Network (LGN is sequencing chromosomes of the trypanosomatid protozoan species Leishmania major. At SBRI, chromosomal sequence is annotated using a combination of trained and untrained non-consensus gene-prediction algorithms with ARTEMIS, an annotation platform with rich and user-friendly interfaces. Results Here we describe a methodology used to import results from three different protein-coding gene-prediction algorithms (GLIMMER, TESTCODE and GENESCAN into the ARTEMIS sequence viewer and annotation tool. Comparison of these methods, along with the CODONUSAGE algorithm built into ARTEMIS, shows the importance of combining methods to more accurately annotate the L. major genomic sequence. Conclusion An improvised and powerful tool for gene prediction has been developed by importing data from widely-used algorithms into an existing annotation platform. This approach is especially fruitful in the Leishmania genome project where there is large proportion of novel genes requiring manual annotation.

  16. Human Genome Project discoveries: Dialectics and rhetoric in the science of genetics

    Science.gov (United States)

    Robidoux, Charlotte A.

    The Human Genome Project (HGP), a $437 million effort that began in 1990 to chart the chemical sequence of our three billion base pairs of DNA, was completed in 2003, marking the 50th anniversary that proved the definitive structure of the molecule. This study considered how dialectical and rhetorical arguments functioned in the science, political, and public forums over a 20-year period, from 1980 to 2000, to advance human genome research and to establish the official project. I argue that Aristotle's continuum of knowledge--which ranges from the probable on one end to certified or demonstrated knowledge on the other--provides useful distinctions for analyzing scientific reasoning. While contemporary scientific research seeks to discover certified knowledge, investigators generally employ the hypothetico-deductive or scientific method, which often yields probable rather than certain findings, making these dialectical in nature. Analysis of the discourse describing human genome research revealed the use of numerous rhetorical figures and topics. Persuasive and probable reasoning were necessary for scientists to characterize unknown genetic phenomena, to secure interest in and funding for large-scale human genome research, to solve scientific problems, to issue probable findings, to convince colleagues and government officials that the findings were sound and to disseminate information to the public. Both government and private venture scientists drew on these tools of reasoning to promote their methods of mapping and sequencing the genome. The debate over how to carry out sequencing was rooted in conflicting values. Scientists representing the academic tradition valued a more conservative method that would establish high quality results, and those supporting private industry valued an unconventional approach that would yield products and profits more quickly. Values in turn influenced political and public forum arguments. Agency representatives and investors sided

  17. Annual genome conference. Final report, September 1, 1994--August 31, 1995

    Energy Technology Data Exchange (ETDEWEB)

    Gardiner, K.

    1995-11-01

    Tremendous progress has been made in the construction of physical and genetic maps of the human chromosomes. The next step in the solving of disease related problems, and in understanding the human genome as a whole, is the systematic isolation of transcribed sequences. Many investigators have already embarked upon comprehensive gene searches, and many more are considering the best strategies for undertaking such searches. Because these are likely to be costly and time consuming endeavors, it is important to determine the most efficient approaches. As a result, it is critical that investigators involved in the construction of transcriptional maps have the opportunity to discuss their experiences and their successes with both old and new technologies. This document contains the proceedings of the Fourth Annual Workshop on the Identification of Transcribed Sequences, held in Montreal, Quebec, October 16-18, 1994. Included are the workshop notebook, containing the agenda, abstracts presented and list of attendees. Topics included: Progress in the application of the hybridization based approaches and exon trapping; Progress in transcriptional map construction of selected genomic regions; Computer assisted analysis of genomic and protein coding sequences and additional new approaches; and, Sequencing and mapping of random cDNAs.

  18. Commentary: The Materials Project: A materials genome approach to accelerating materials innovation

    Directory of Open Access Journals (Sweden)

    Anubhav Jain

    2013-07-01

    Full Text Available Accelerating the discovery of advanced materials is essential for human welfare and sustainable, clean energy. In this paper, we introduce the Materials Project (www.materialsproject.org, a core program of the Materials Genome Initiative that uses high-throughput computing to uncover the properties of all known inorganic materials. This open dataset can be accessed through multiple channels for both interactive exploration and data mining. The Materials Project also seeks to create open-source platforms for developing robust, sophisticated materials analyses. Future efforts will enable users to perform ‘‘rapid-prototyping’’ of new materials in silico, and provide researchers with new avenues for cost-effective, data-driven materials design.

  19. Final report of the project performance assessment and economic evaluation of nuclear waste management

    International Nuclear Information System (INIS)

    Rasilainen, K.; Anttila, M.; Hautojaervi, A.

    1993-05-01

    The publication is the final report of project Performance Assessment and Economic Evaluation of Nuclear Waste Management (TOKA) at the Nuclear Engineering Laboratory of VTT (Technical Research Centre of Finland), forming part of the Publicly Financed Nuclear Waste Management Research Programme (JYT). The project covers safety and cost aspects of all phases of nuclear waste management. The main emphasis has been on developing an integrated system of models for performance assessment of nuclear waste repositories. During the four years the project has so far been in progress, the total amount of work has been around 14 person-years. Computer codes are the main tools in the project, they are either developed by the project team or acquired from abroad. In-house model development has been especially active in groundwater flow, near-field and migration modelling. The quantitative interpretation of Finnish tracer experiments in the laboratory and natural analogue studies at Palmottu support performance assessments via increased confidence in the migration concepts used. The performance assessment philosophy adopted by the team consists of deterministic modelling and pragmatic scenario analysis. This is supported by the long-term experience in practical performance assessment of the team, and in theoretical probabilistic modelling exercises. The radiological risks of spent fuel transportation from the Loviisa nuclear power plant to Russia have been analysed using a probabilistic computer code and Finnish traffic accident statistics. The project assists the authorities in the annual assessment of utility estimates of funding needs for future nuclear waste management operations. The models and methods used within the project are tested in international verification/validation projects

  20. A haplotype regression approach for genetic evaluation using sequences from the 1000 bull genomes Project

    International Nuclear Information System (INIS)

    Lakhssassi, K.; González-Recio, O.

    2017-01-01

    Haplotypes from sequencing data may improve the prediction accuracy in genomic evaluations as haplotypes are in stronger linkage disequilibrium with quantitative trait loci than markers from SNP chips. This study focuses first, on the creation of haplotypes in a population sample of 450 Holstein animals, with full-sequence data from the 1000 bull genomes project; and second, on incorporating them into the whole genome prediction model. In total, 38,319,258 SNPs (and indels) from Next Generation Sequencing were included in the analysis. After filtering variants with minor allele frequency (MAF< 0.025) 13,912,326 SNPs were available for the haplotypes extraction with findhap.f90. The number of SNPs in the haploblocks was on average 924 SNP (166,552 bp). Unique haplotypes were around 97% in all chromosomes and were ignored leaving 153,428 haplotypes. Estimated haplotypes had a large contribution to the total variance of genomic estimated breeding values for kilogram of protein, Global Type Index, Somatic Cell Score and Days Open (between 32 and 99.9%). Haploblocks containing haplotypes with large effects were selected by filtering for each trait, haplotypes whose effect was larger/lower than the mean plus/minus 3 times the standard deviation (SD) and 1 SD above the mean of the haplotypes effect distribution. Results showed that filtering by 3 SD would not be enough to capture a large proportion of genetic variance, whereas filtering by 1 SD could be useful but model convergence should be considered. Additionally, sequence haplotypes were able to capture additional genetic variance to the polygenic effect for traits undergoing lower selection intensity like fertility and health traits.

  1. A haplotype regression approach for genetic evaluation using sequences from the 1000 bull genomes Project

    Energy Technology Data Exchange (ETDEWEB)

    Lakhssassi, K.; González-Recio, O.

    2017-07-01

    Haplotypes from sequencing data may improve the prediction accuracy in genomic evaluations as haplotypes are in stronger linkage disequilibrium with quantitative trait loci than markers from SNP chips. This study focuses first, on the creation of haplotypes in a population sample of 450 Holstein animals, with full-sequence data from the 1000 bull genomes project; and second, on incorporating them into the whole genome prediction model. In total, 38,319,258 SNPs (and indels) from Next Generation Sequencing were included in the analysis. After filtering variants with minor allele frequency (MAF< 0.025) 13,912,326 SNPs were available for the haplotypes extraction with findhap.f90. The number of SNPs in the haploblocks was on average 924 SNP (166,552 bp). Unique haplotypes were around 97% in all chromosomes and were ignored leaving 153,428 haplotypes. Estimated haplotypes had a large contribution to the total variance of genomic estimated breeding values for kilogram of protein, Global Type Index, Somatic Cell Score and Days Open (between 32 and 99.9%). Haploblocks containing haplotypes with large effects were selected by filtering for each trait, haplotypes whose effect was larger/lower than the mean plus/minus 3 times the standard deviation (SD) and 1 SD above the mean of the haplotypes effect distribution. Results showed that filtering by 3 SD would not be enough to capture a large proportion of genetic variance, whereas filtering by 1 SD could be useful but model convergence should be considered. Additionally, sequence haplotypes were able to capture additional genetic variance to the polygenic effect for traits undergoing lower selection intensity like fertility and health traits.

  2. The analysis of APOL1 genetic variation and haplotype diversity provided by 1000 Genomes project.

    Science.gov (United States)

    Peng, Ting; Wang, Li; Li, Guisen

    2017-08-11

    The APOL1 gene variants has been shown to be associated with an increased risk of multiple kinds of diseases, particularly in African Americans, but not in Caucasians and Asians. In this study, we explored the single nucleotide polymorphism (SNP) and haplotype diversity of APOL1 gene in different races provided by 1000 Genomes project. Variants of APOL1 gene in 1000 Genome Project were obtained and SNPs located in the regulatory region or coding region were selected for genetic variation analysis. Total 2504 individuals from 26 populations were classified as four groups that included Africa, Europe, Asia and Admixed populations. Tag SNPs were selected to evaluate the haplotype diversities in the four populations by HaploStats software. APOL1 gene was surrounded by some of the most polymorphic genes in the human genome, variation of APOL1 gene was common, with up to 613 SNP (1000 Genome Project reported) and 99 of them (16.2%) with MAF ≥ 1%. There were 79 SNPs in the URR and 92 SNPs in 3'UTR. Total 12 SNPs in URR and 24 SNPs in 3'UTR were considered as common variants with MAF ≥ 1%. It is worth noting that URR-1 was presents lower frequencies in European populations, while other three haplotypes taken an opposite pattern; 3'UTR presents several high-frequency variation sites in a short segment, and the differences of its haplotypes among different population were significant (P < 0.01), UTR-1 and UTR-5 presented much higher frequency in African population, while UTR-2, UTR-3 and UTR-4 were much lower. APOL1 coding region showed that two SNP of G1 with higher frequency are actually pull down the haplotype H-1 frequency when considering all populations pooled together, and the diversity among the four populations be widen by the G1 two mutation (P 1  = 3.33E-4 vs P 2  = 3.61E-30). The distributions of APOL1 gene variants and haplotypes were significantly different among the different populations, in either regulatory or coding regions. It could provide

  3. Bridging the Divide: Linking Genomics to Ecosystem Responses to Climate Change: Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Smith, Melinda D.

    2014-03-15

    Over the project period, we have addressed the following objectives: 1) assess the effects of altered precipitation patterns (i.e., increased variability in growing season precipitation) on genetic diversity of the dominant C4 grass species, Andropogon gerardii, and 2) experimentally assess the impacts of extreme climatic events (heat wave, drought) on responses of the dominant C4 grasses, A. gerardii and Sorghastrum nutans, and the consequences of these response for community and ecosystem structure and function. Below is a summary of how we have addressed these objectives. Objective 1 After ten years of altered precipitation, we found the number of genotypes of A. gerardii was significantly reduced compared to the ambient precipitation treatments (Avolio et al., 2013a). Although genotype number was reduced, the remaining genotypes were less related to one another indicating that the altered precipitation treatment was selecting for increasingly dissimilar genomes (based on mean pairwise Dice distance among individuals). For the four key genotypes that displayed differential abundances depending on the precipitation treatment (G1, G4, and G11 in the altered plots and G2 in the ambient plots), we identified phenotypic differences in the field that could account for ecological sorting (Avolio & Smith, 2013a). The three altered rainfall genotypes also have very different phenotypic traits in the greenhouse in response to different soil moisture availabilities (Avolio and Smith, 2013c). Two of the genotypes that increased in abundance in the altered precipitation plots had greater allocation to root biomass (G4 and G11), while G1 allocated more biomass aboveground. These phenotypic differences among genotypes suggests that changes in genotypic structure between the altered and the ambient treatments has likely occurred via niche differentiation, driven by changes in soil moisture dynamics (reduced mean, increased variability and changes in the depth distribution of

  4. TcruziDB, an Integrated Database, and the WWW Information Server for the Trypanosoma cruzi Genome Project

    Directory of Open Access Journals (Sweden)

    Degrave Wim

    1997-01-01

    Full Text Available Data analysis, presentation and distribution is of utmost importance to a genome project. A public domain software, ACeDB, has been chosen as the common basis for parasite genome databases, and a first release of TcruziDB, the Trypanosoma cruzi genome database, is available by ftp from ftp://iris.dbbm.fiocruz.br/pub/genomedb/TcruziDB as well as versions of the software for different operating systems (ftp://iris.dbbm.fiocruz.br/pub/unixsoft/. Moreover, data originated from the project are available from the WWW server at http://www.dbbm.fiocruz.br. It contains biological and parasitological data on CL Brener, its karyotype, all available T. cruzi sequences from Genbank, data on the EST-sequencing project and on available libraries, a T. cruzi codon table and a listing of activities and participating groups in the genome project, as well as meeting reports. T. cruzi discussion lists (tcruzi-l@iris.dbbm.fiocruz.br and tcgenics@iris.dbbm.fiocruz.br are being maintained for communication and to promote collaboration in the genome project

  5. Mapping and sequencing the human genome: Science, ethics, and public policy. Final report

    Energy Technology Data Exchange (ETDEWEB)

    McInerney, J.D.

    1993-03-31

    Development of Mapping and Sequencing the Human Genome: Science, Ethics, and Public Policy followed the standard process of curriculum development at the Biological Sciences Curriculum Study (BSCS), the process is described. The production of this module was a collaborative effort between BSCS and the American Medical Association (AMA). Appendix A contains a copy of the module. Copies of reports sent to the Department of Energy (DOE) during the development process are contained in Appendix B; all reports should be on file at DOE. Appendix B also contains copies of status reports submitted to the BSCS Board of Directors.

  6. Identifying Problems in Students’ Final Projects Based on Scientific Writing Guidelines

    Directory of Open Access Journals (Sweden)

    Endang Ernawati

    2010-11-01

    Full Text Available Article analyzed student’s difficulties and abilities in writing their final projects, which were undergraduate theses and undergraduate paper conducted by some students at the English Department, Bina Nusantara University. This was a preliminary study to support an appropriate student guideline in writing their final project. The study was conducted by applying qualitative methods that was by analyzing the four theses and one paper in terms of their format: titles, introduction, theoretical background, analysis, conclusion, bibliography, and paper rubric to analyze the contents. It can be concluded that generally, students, guided by their mentor/lecturer, understand the final paper guidelines and they are able to apply it in their thesis and paper. But, there are still lack of clarity and relevancy in expressing their ideas properly, and their ability in writing in both English and Bahasa Indonesia must be improved. These problems can be overcome by socializing the writing guidelines to both students and lecturers, providing them with critical thinking skills, cooperation with library that will guide them in information literacy skills, and language center that will improve their writing skills. 

  7. The final disposal of radioactive wastes as social, political and scientific project - an introduction

    International Nuclear Information System (INIS)

    Brunnengraeber, Achim

    2015-01-01

    The nuclear power production that was productive for two generations produces radioactive wastes that will be a hazardous and financial burden for many future generations. Science, politics, industry and the society are responsible to find a successful solution for the project of final disposal of radioactive wastes. With the fast development of renewable energies with the perspectives of sustainability and other advantages nuclear power will not have a remarkable future. The search for a final repository site is a tremendous governmental, economic and public challenge but can also be seen as a social chance. Democracy could be enforced by this process, public commitment, transparency, co-determination, confidence in political processes are indispensible premises.

  8. Proposed modifications to the Lower Mokelumne River Project, California: FERC Project No. 2916-004. Final environmental impact statement

    Energy Technology Data Exchange (ETDEWEB)

    1993-11-01

    This final environmental impact statement (FEIS) has been prepared for the Federal Energy Regulatory Commission (Commission) to consider modifications to the existing Lower Mokelumne River Project (LMRP) (FERC Project No. 2916-004) in California. Chinook salmon and steelhead trout populations in the lower Mokelumne River have experienced recent declines and fish kills associated, in part, with discharges from Camanche Dam. The California Department of Fish and Game and the California Sportfishing Protection Alliance have asked the Commission to investigate and correct these problems. A wide range of different mitigation actions has been proposed by parties participating in the scoping of this proceeding, and staff has evaluated these proposed actions in this assessment. The staff is recommending a combination of flow and non-flow modifications to the existing license, including new minimum flow and minimum pool elevation requirements at Camanche Reservoir, ramping rates on dam releases, interim attraction and out-migrant spike flows, instream habitat improvements, and a series of studies and monitoring to determine feasible means for solving off-site fish passage problems.

  9. Terahertz spectral signatures :measurement and detection LDRD project 86361 final report.

    Energy Technology Data Exchange (ETDEWEB)

    Wanke, Michael Clement; Brener, Igal; Lee, Mark

    2005-11-01

    LDRD Project 86361 provided support to upgrade the chemical and material spectral signature measurement and detection capabilities of Sandia National Laboratories using the terahertz (THz) portion of the electromagnetic spectrum, which includes frequencies between 0.1 to 10 THz. Under this project, a THz time-domain spectrometer was completed. This instrument measures sample absorption spectra coherently, obtaining both magnitude and phase of the absorption signal, and has shown an operating signal-to-noise ratio of 10{sub 4}. Additionally, various gas cells and a reflectometer were added to an existing high-resolution THz Fourier transform spectrometer, which greatly extend the functionality of this spectrometer. Finally, preliminary efforts to design an integrated THz transceiver based on a quantum cascade laser were begun.

  10. Final report on the Project Research 'Assessment of Human Exposure to Environmental Radiation'

    International Nuclear Information System (INIS)

    1989-03-01

    This is the final report of the Project Research, 'Assessment of Human Exposure to Environmental Radiation', which has been conducted during the period 1983-1988. With the objective of assessing risk of environmental radioactivity to the population, the Project was divided into the following five research groups: (1) research for establishing calculation models and parameters in transfer of radionuclides from crop species through the human body; (2) research for analyzing transfer of radionuclides in the ocean and their contributions to exposure doses in the human body; (3) research for surveying accuracy of exposure models for the external body and respiratory organ and the influential factors; (4) research for determining uptake and biokinetics of radionuclides in the body; and (5) research for estimating and evaluating physical and physiological characteristics of reference Japanese man and the populaltion doses. Effluents from nuclear power plants and reprocessing plants were regarded as radionuclide sources in the water and atmosphere. (N.K.)

  11. Smart Intelligent Aircraft Structures (SARISTU) : Proceedings of the Final Project Conference

    CERN Document Server

    Papadopoulos, Michael

    2016-01-01

    The book includes the research papers presented in the final conference of the EU funded SARISTU (Smart Intelligent Aircraft Structures) project, held at Moscow, Russia between 19-21 of May 2015. The SARISTU project, which was launched in September 2011, developed and tested a variety of individual applications as well as their combinations. With a strong focus on actual physical integration and subsequent material and structural testing, SARISTU has been responsible for important progress on the route to industrialization of structure integrated functionalities such as Conformal Morphing, Structural Health Monitoring and Nanocomposites. The gap- and edge-free deformation of aerodynamic surfaces known as conformal morphing has gained previously unrealized capabilities such as inherent de-icing, erosion protection and lightning strike protection, while at the same time the technological risk has been greatly reduced. Individual structural health monitoring techniques can now be applied at the part-manufacturin...

  12. UCSD Performance in the Edge Plasma Simulation (EPSI) Project. Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Tynan, George Robert [Univ. of California, San Diego, CA (United States). Center for Energy Research

    2017-12-12

    This report contains a final report on the activities of UC San Diego PI G.R. Tynan and his collaborators as part of the EPSI Project, that was led by Dr. C.S. Chang, from PPPL. As a part of our work, we carried out several experiments on the ALCATOR C-­MOD tokamak device, aimed at unraveling the “trigger” or cause of the spontaneous transition from low-­mode confinement (L-­mode) to high confinement (H-­mode) that is universally observed in tokamak devices, and is planned for use in ITER.

  13. Technical approach to finalizing sensible soil cleanup levels at the Fernald Environmental Management Project

    International Nuclear Information System (INIS)

    Carr, D.; Hertel, B.; Jewett, M.; Janke, R.; Conner, B.

    1996-01-01

    The remedial strategy for addressing contaminated environmental media was recently finalized for the US Department of Energy's (DOE) Fernald Environmental Management Project (FEMP) following almost 10 years of detailed technical analysis. The FEMP represents one of the first major nuclear facilities to successfully complete the Remedial Investigation/Feasibility Study (RI/FS) phase of the environmental restoration process. A critical element of this success was the establishment of sensible cleanup levels for contaminated soil and groundwater both on and off the FEMP property. These cleanup levels were derived based upon a strict application of Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) regulations and guidance, coupled with positive input from the regulatory agencies and the local community regarding projected future land uses for the site. The approach for establishing the cleanup levels was based upon a Feasibility Study (FS) strategy that examined a bounding range of viable future land uses for the site. Within each land use, the cost and technical implications of a range of health-protective cleanup levels for the environmental media were analyzed. Technical considerations in driving these cleanup levels included: direct exposure routes to viable human receptors; cross- media impacts to air, surface water, and groundwater; technical practicality of attaining the levels; volume of affected media; impact to sensitive environmental receptors or ecosystems; and cost. This paper will discuss the technical approach used to support the finalization of the cleanup levels for the site. The final cleanup levels provide the last remaining significant piece to the puzzle of establishing a final site-wide remedial strategy for the FEMP, and positions the facility for the expedient completion of site-wide remedial activities

  14. Independent management and financial review, Yucca Mountain Project, Nevada. Final report, Appendix

    International Nuclear Information System (INIS)

    1995-01-01

    The Nuclear Waste Policy Act of 1982 (Public Law 97-425), as amended by Public Law 100-203, December 22, 1987, established the Office of Civilian Radioactive Waste Management (OCRWM) within the Department of Energy (DOE), and directed the Office to investigate a site at Yucca Mountain, Nevada, to determine if this site is suitable for the construction of a repository for the disposal of high level nuclear waste. Work on site characterization has been under way for several years. Thus far, about $1.47 billion have been spent on Yucca Mountain programs. This work has been funded by Congressional appropriations from a Nuclear Waste Fund to which contributions have been made by electric utility ratepayers through electric utilities generating power from nuclear power stations. The Secretary of Energy and the Governor of the State of Nevada have appointed one person each to a panel to oversee an objective, independent financial and management evaluation of the Yucca Mountain Project. The Requirements for the work will include an analysis of (1) the Yucca Mountain financial and, contract management techniques and controls; (2) Project schedules and credibility of the proposed milestones; (3) Project organizational effectiveness and internal planning processes, and (4) adequacy of funding levels and funding priorities, including the cost of infrastructure and scientific studies. The recipient will provide monthly progress report and the following reports/documents will be presented as deliverables under the contract: (1) Financial and Contract Management Preliminary Report; (2) Project Scheduling Preliminary Report; (3)Project Organizational Effectiveness Preliminary Report; (4) Project Funding Levels and Funding Priorities Preliminary Report; and (5) Final Report

  15. Independent management and financial review, Yucca Mountain Project, Nevada. Final report, Appendix

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-07-15

    The Nuclear Waste Policy Act of 1982 (Public Law 97-425), as amended by Public Law 100-203, December 22, 1987, established the Office of Civilian Radioactive Waste Management (OCRWM) within the Department of Energy (DOE), and directed the Office to investigate a site at Yucca Mountain, Nevada, to determine if this site is suitable for the construction of a repository for the disposal of high level nuclear waste. Work on site characterization has been under way for several years. Thus far, about $1.47 billion have been spent on Yucca Mountain programs. This work has been funded by Congressional appropriations from a Nuclear Waste Fund to which contributions have been made by electric utility ratepayers through electric utilities generating power from nuclear power stations. The Secretary of Energy and the Governor of the State of Nevada have appointed one person each to a panel to oversee an objective, independent financial and management evaluation of the Yucca Mountain Project. The Requirements for the work will include an analysis of (1) the Yucca Mountain financial and, contract management techniques and controls; (2) Project schedules and credibility of the proposed milestones; (3) Project organizational effectiveness and internal planning processes, and (4) adequacy of funding levels and funding priorities, including the cost of infrastructure and scientific studies. The recipient will provide monthly progress report and the following reports/documents will be presented as deliverables under the contract: (1) Financial and Contract Management Preliminary Report; (2) Project Scheduling Preliminary Report; (3)Project Organizational Effectiveness Preliminary Report; (4) Project Funding Levels and Funding Priorities Preliminary Report; and (5) Final Report.

  16. Understanding our genetic inheritance: The US Human Genome Project, The first five years FY 1991--1995

    Energy Technology Data Exchange (ETDEWEB)

    None

    1990-04-01

    The Human Genome Initiative is a worldwide research effort with the goal of analyzing the structure of human DNA and determining the location of the estimated 100,000 human genes. In parallel with this effort, the DNA of a set of model organisms will be studied to provide the comparative information necessary for understanding the functioning of the human genome. The information generated by the human genome project is expected to be the source book for biomedical science in the 21st century and will by of immense benefit to the field of medicine. It will help us to understand and eventually treat many of the more than 4000 genetic diseases that affect mankind, as well as the many multifactorial diseases in which genetic predisposition plays an important role. A centrally coordinated project focused on specific objectives is believed to be the most efficient and least expensive way of obtaining this information. The basic data produced will be collected in electronic databases that will make the information readily accessible on convenient form to all who need it. This report describes the plans for the U.S. human genome project and updates those originally prepared by the Office of Technology Assessment (OTA) and the National Research Council (NRC) in 1988. In the intervening two years, improvements in technology for almost every aspect of genomics research have taken place. As a result, more specific goals can now be set for the project.

  17. O admirável Projeto Genoma Humano The brave New Human Genome Project

    Directory of Open Access Journals (Sweden)

    Marilena V. Corrêa

    2002-12-01

    Full Text Available Este artigo apresenta um panorama das implicações sociais, éticas e legais do Projeto Genoma Humano. Os benefícios desse megaprojeto, traduzidos em promessas de uma revolução terapêutica na medicina, não se realizarão sem conflitos. O processo de inovação tecnológica na genética traz problemas de ordens diversas: por um lado, pesquisas em consórcio, patenteamento de genes e produtos da genômica apontam interesses comerciais e dificuldades de gerenciamento dos resultados dessas pesquisas. Esses problemas colocam desafios em termos de uma possível desigualdade no acesso aos benefícios das pesquisas. Por outro lado, temos a questão da informação genética e da proteção de dados individuais sobre riscos e suscetibilidades a doenças e atributos humanos. O problema da definição de homens e mulheres em função de traços genéticos traz uma ameaça discriminatória clara, e se torna agudo em função do reducionismo genético que a mídia ajuda a propagar. As respostas a esses problemas não podem ser esperadas apenas da bioética. A abordagem bioética deve poder combinar-se a análises políticas da reprodução, da sexualidade, da saúde e da medicina. Um vastíssimo espectro de problemas como estes não pode ser discutido em profundidade em um artigo. Optou-se por mapeá-los no sentido de enfatizar em que medida, na reflexão sobre o projeto genoma, a genômica e a pós-genômica, enfrenta-se o desafio de articular aspectos tão diferenciados.This article presents an overview of the social, ethical, and legal implications of the Human Genome Project. The benefits of this mega-project, expressed as promises of a therapeutic revolution in medicine, will not be achieved without conflict. The process of technological innovation in genetics poses problems of various orders: on the one hand, consortium-based research, gene patenting, and genomic products tend to feature commercial interests and management of the results of such

  18. The GenABEL Project for statistical genomics [version 1; referees: 2 approved

    Directory of Open Access Journals (Sweden)

    Lennart C. Karssen

    2016-05-01

    Full Text Available Development of free/libre open source software is usually done by a community of people with an interest in the tool. For scientific software, however, this is less often the case. Most scientific software is written by only a few authors, often a student working on a thesis. Once the paper describing the tool has been published, the tool is no longer developed further and is left to its own device. Here we describe the broad, multidisciplinary community we formed around a set of tools for statistical genomics. The GenABEL project for statistical omics actively promotes open interdisciplinary development of statistical methodology and its implementation in efficient and user-friendly software under an open source licence. The software tools developed withing the project collectively make up the GenABEL suite, which currently consists of eleven tools. The open framework of the project actively encourages involvement of the community in all stages, from formulation of methodological ideas to application of software to specific data sets. A web forum is used to channel user questions and discussions, further promoting the use of the GenABEL suite. Developer discussions take place on a dedicated mailing list, and development is further supported by robust development practices including use of public version control, code review and continuous integration. Use of this open science model attracts contributions from users and developers outside the “core team”, facilitating agile statistical omics methodology development and fast dissemination.

  19. Human Genome Diversity Project. Summary of planning workshop 3(B): Ethical and human-rights implications

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1993-12-31

    The third planning workshop of the Human Genome Diversity Project was held on the campus of the US National Institutes of Health in Bethesda, Maryland, from February 16 through February 18, 1993. The second day of the workshop was devoted to an exploration of the ethical and human-rights implications of the Project. This open meeting centered on three roundtables, involving 12 invited participants, and the resulting discussions among all those present. Attendees and their affiliations are listed in the attached Appendix A. The discussion was guided by a schedule and list of possible issues, distributed to all present and attached as Appendix B. This is a relatively complete, and thus lengthy, summary of the comments at the meeting. The beginning of the summary sets out as conclusions some issues on which there appeared to be widespread agreement, but those conclusions are not intended to serve as a set of detailed recommendations. The meeting organizer is distributing his recommendations in a separate memorandum; recommendations from others who attended the meeting are welcome and will be distributed by the meeting organizer to the participants and to the Project committee.

  20. High-throughput crystal-optimization strategies in the South Paris Yeast Structural Genomics Project: one size fits all?

    Science.gov (United States)

    Leulliot, Nicolas; Trésaugues, Lionel; Bremang, Michael; Sorel, Isabelle; Ulryck, Nathalie; Graille, Marc; Aboulfath, Ilham; Poupon, Anne; Liger, Dominique; Quevillon-Cheruel, Sophie; Janin, Joël; van Tilbeurgh, Herman

    2005-06-01

    Crystallization has long been regarded as one of the major bottlenecks in high-throughput structural determination by X-ray crystallography. Structural genomics projects have addressed this issue by using robots to set up automated crystal screens using nanodrop technology. This has moved the bottleneck from obtaining the first crystal hit to obtaining diffraction-quality crystals, as crystal optimization is a notoriously slow process that is difficult to automatize. This article describes the high-throughput optimization strategies used in the Yeast Structural Genomics project, with selected successful examples.

  1. BIOETHICS METHODS IN THE ETHICAL, LEGAL, AND SOCIAL IMPLICATIONS OF THE HUMAN GENOME PROJECT LITERATURE

    Science.gov (United States)

    Walker, Rebecca; Morrissey, Clair

    2013-01-01

    While bioethics as a field has concerned itself with methodological issues since the early years, there has been no systematic examination of how ethics is incorporated into research on the Ethical, Legal and Social Implications (ELSI) of the Human Genome Project. Yet ELSI research may bear a particular burden of investigating and substantiating its methods given public funding, an explicitly cross-disciplinary approach, and the perceived significance of adequate responsiveness to advances in genomics. We undertook a qualitative content analysis of a sample of ELSI publications appearing between 2003-2008 with the aim of better understanding the methods, aims, and approaches to ethics that ELSI researchers employ. We found that the aims of ethics within ELSI are largely prescriptive and address multiple groups. We also found that the bioethics methods used in the ELSI literature are both diverse between publications and multiple within publications, but are usually not themselves discussed or employed as suggested by bioethics method proponents. Ethics in ELSI is also sometimes undistinguished from related inquiries (such as social, legal, or political investigations). PMID:23796275

  2. The human genome project and novel aspects of cytochrome P450 research

    International Nuclear Information System (INIS)

    Ingelman-Sundberg, Magnus

    2005-01-01

    Currently, 57 active cytochrome P450 (CYP) genes and 58 pseudogenes are known to be present in the human genome. Among the genes discovered by initiatives in the human genome project are CYP2R1, CYP2W1, CYP2S1, CYP2U1 and CYP3A43, the latter apparently encoding a pseudoenzyme. The function, polymorphism and regulation of these genes are still to be discovered to a great extent. The polymorphism of drug metabolizing CYPs is extensive and influences the outcome of drug therapy causing lack of response or adverse drug reactions. The basis for the differences in the global distribution of the polymorphic variants is inactivating gene mutations and subsequent genetic drift. However, polymorphic alleles carrying multiple active gene copies also exist and are suggested in case of CYP2D6 to be caused by positive selection due to development of alkaloid resistance in North East Africa about 10,000-5000 BC. The knowledge about the CYP genes and their polymorphisms is of fundamental importance for effective drug therapy and for drug development as well as for understanding metabolic activation of carcinogens and other xenobiotics. Here, a short review of the current knowledge is given

  3. Mitogenomes from The 1000 Genome Project reveal new Near Eastern features in present-day Tuscans.

    Directory of Open Access Journals (Sweden)

    Alberto Gómez-Carballa

    Full Text Available Genetic analyses have recently been carried out on present-day Tuscans (Central Italy in order to investigate their presumable recent Near East ancestry in connection with the long-standing debate on the origins of the Etruscan civilization. We retrieved mitogenomes and genome-wide SNP data from 110 Tuscans analyzed within the context of The 1000 Genome Project. For phylogeographic and evolutionary analysis we made use of a large worldwide database of entire mitogenomes (>26,000 and partial control region sequences (>180,000.Different analyses reveal the presence of typical Near East haplotypes in Tuscans representing isolated members of various mtDNA phylogenetic branches. As a whole, the Near East component in Tuscan mitogenomes can be estimated at about 8%; a proportion that is comparable to previous estimates but significantly lower than admixture estimates obtained from autosomal SNP data (21%. Phylogeographic and evolutionary inter-population comparisons indicate that the main signal of Near Eastern Tuscan mitogenomes comes from Iran.Mitogenomes of recent Near East origin in present-day Tuscans do not show local or regional variation. This points to a demographic scenario that is compatible with a recent arrival of Near Easterners to this region in Italy with no founder events or bottlenecks.

  4. Long term Gas Supply Security in an Enlarged Europe. Final Report ENGAGED Project

    International Nuclear Information System (INIS)

    Van Oostvoorn, F.; Likachev, V.; Morgan, T.

    2004-12-01

    The title project concerned a study on the long-term gas supply security in Europe with a focus on the developments, risks and policies in the candidate countries in Eastern Europe. For that reason the report not only includes a European and EU-30 wide scenario analysis but also chapters on specific topics. One study (a chapter in this report) concerns the gas market and regulation developments in a number of relevant candidate countries. Another chapter presents a Russian vision on gas demand, production and supplies from Russia and also includes a paragraph on the supplies from other neighbours and the transit issues in the Ukraine. Finally, the report contains a chapter discussing the required network infrastructure for bringing the gas from external gas suppliers to the EU-30 markets. Hereby it analysis and tests the network flexibility to cope with some unlikely and unexpected supply interruptions in main pipelines to EU markets. The background information of the studies underlying the chapters can be partly found in the annexes and in the individual task reports. During the project the results of the study were discussed at several seminars in candidate countries and particularly on the final seminar in Prague, in June 2003, with different and important stakeholders and market actors

  5. US Department of Energy Grand Junction Projects Office Remedial Action Project, final report of the decontamination and decommissioning of Building 36 at the Grand Junction Projects Office Facility

    International Nuclear Information System (INIS)

    Widdop, M.R.

    1996-08-01

    The U.S. Department of Energy (DOE) Grand Junction Projects Office (GJPO) occupies a 61.7-acre facility along the Gunnison River near Grand Junction, Colorado. This site was contaminated with uranium ore and mill tailings during uranium refining activities of the Manhattan Engineer District and during pilot milling experiments conducted for the U.S. Atomic Energy Commission's domestic uranium procurement program. The DOE Defense Decontamination and Decommissioning Program established the GJPO Remedial Action Project to clean up and restore the facility lands, improvements, and the underlying aquifer. The site contractor for the facility, Rust Geotech, also is the remedial action contractor. Building 36 was found to be radiologically contaminated and was demolished in 1996. The soil beneath the building was remediated in accordance with identified standards and can be released for unlimited exposure and unrestricted use. This document was prepared in response to a DOE request for an individual final report for each contaminated GJPO building

  6. Lessons learned in demonstration projects regarding operational safety during final disposal of vitrified waste and spent fuel

    International Nuclear Information System (INIS)

    Filbert, Wolfgang; Herold, Philipp

    2015-01-01

    The paper summarizes the lessons learned in demonstration projects regarding operational safety during the final disposal of vitrified waste and spent fuel. The three demonstration projects for the direct disposal of vitrified waste and spent fuel are described. The first two demonstration projects concern the shaft transport of heavy payloads of up to 85 t and the emplacement operations in the mine. The third demonstration project concerns the borehole emplacement operation. Finally, open issues for the next steps up to licensing of the emplacement and disposal systems are summarized.

  7. Bat Biology, Genomes, and the Bat1K Project: To Generate Chromosome-Level Genomes for All Living Bat Species.

    Science.gov (United States)

    Teeling, Emma C; Vernes, Sonja C; Dávalos, Liliana M; Ray, David A; Gilbert, M Thomas P; Myers, Eugene

    2018-02-15

    Bats are unique among mammals, possessing some of the rarest mammalian adaptations, including true self-powered flight, laryngeal echolocation, exceptional longevity, unique immunity, contracted genomes, and vocal learning. They provide key ecosystem services, pollinating tropical plants, dispersing seeds, and controlling insect pest populations, thus driving healthy ecosystems. They account for more than 20% of all living mammalian diversity, and their crown-group evolutionary history dates back to the Eocene. Despite their great numbers and diversity, many species are threatened and endangered. Here we announce Bat1K, an initiative to sequence the genomes of all living bat species (n∼1,300) to chromosome-level assembly. The Bat1K genome consortium unites bat biologists (>148 members as of writing), computational scientists, conservation organizations, genome technologists, and any interested individuals committed to a better understanding of the genetic and evolutionary mechanisms that underlie the unique adaptations of bats. Our aim is to catalog the unique genetic diversity present in all living bats to better understand the molecular basis of their unique adaptations; uncover their evolutionary history; link genotype with phenotype; and ultimately better understand, promote, and conserve bats. Here we review the unique adaptations of bats and highlight how chromosome-level genome assemblies can uncover the molecular basis of these traits. We present a novel sequencing and assembly strategy and review the striking societal and scientific benefits that will result from the Bat1K initiative.

  8. Spent fuel stability under repository conditions - final report of the european project

    International Nuclear Information System (INIS)

    Poinssot, Ch.; Ferry, C.; Kelm, M.; Cavedon, J.M.; Corbel, C.; Jegou, Ch.; Lovera, P.; Miserque, F.; Poulesquen, A.; Grambow, B.; Andriambololona, Z.; Martinez-Esparza, A.; Kelm, M.; Loida, A.; Rondinella, V.; Wegen, D.; Spahiu, K.; Johnson, L.; Cachoir, Ch.; Lemmens, K.; Quinones, J.; Bruno, J.; Christensen, H.; Grambow, B.; Pablo, J. de

    2005-01-01

    This report is the final report of the European Project 'Spent Fuel Stability under Repository Conditions' (FIKW-CT-2001-00192 SFS) funded by the European Commission from Nov.2000 to Oct.2004. Gathering the work performed by 13 partners from 6 countries, it aims to specifically focus on the spent nuclear fuel long term alteration in deep repository and the subsequent radionuclides release rate as a function of time. This report synthesised the wide experimental work performed within this project and enlightens the major outcomes, which can be summarised as follow: - A new model for defining the Instant Release Fraction was developed in order to consider the potential fuel evolution before the water penetrates the canister. Quantitative assessment has been produced and shows a significant contribution to the long term dose; - Based on new experimental data, kinetic radiolytic scheme have been upgraded and are used to determine the amount of oxidants produced at the fuel/water interface; - The existence of a dose threshold below which the water radiolysis does not influence the fuel alteration has been demonstrated and occurs between 3.5 and 33 MBq.g UO21. Above the threshold, the fuel alteration rates is directly related to the dose rate. - Hydrogen was experimentally demonstrated to be an efficient oxidants scavenger preventing therefore the fuel oxidation. Molecular mechanism still need to be understood. - Finally, a new Matrix Alteration Model integrating most of the SFS results (apart of the hydrogen effect) has been developed and used to assess the fuel long tern stability in representative conditions of deep repository in salt, clay-rock and granite. The breadth of the results and the significance of the conclusions testify of the success of the collaboration within the project. (authors)

  9. Functional genomics, an integrated approach. Final report for the Trieste component

    Energy Technology Data Exchange (ETDEWEB)

    Bradbury, Andrew R.M.

    1999-11-01

    Phage display offers the possibility of selecting polypeptides (and the genes which encode them) from libraries of 10 billion or more different polypeptides on the basis of their abilities to bind target proteins and subdomains. The general principle of phage display relies on the coupling of phenotype and genotype in the phage. The specific aims of this project were threefold: (1) to produce a large phagemid antibody library; (2) to develop a general method for deriving antibodies against the protein products of cloned genes; (3) to develop technologies which permit the display of gene fragment libraries on phage. Accomplishments in each of these areas are presented.

  10. Final report on the project research 'stochastic effects of irradiation and risk estimation'

    International Nuclear Information System (INIS)

    1989-03-01

    The title project research was carried out through 1983-1987, by three groups for the studies of radiation carcinogenesis, human genetic effects, and radiotoxicology. 8 reports by the first group, 3 by the second, and 6 by the third group are collected in this issue. The contents are as follows. Serial sacrifice study on tumorigenesis in male C57BL/6J mice exposed to gamma-ray or fast neutron radiation; Influence of biological variables on radiation carcinogenesis; Studies on radiation-induced thymic lymphomagenesis; Modifying factors of radiation induced myeloid leukemia of C3H/He mouse; Cell kinetic studies on radiation induced leukemogenesis; Cytogenetical studies on the mechanism of radiation induced neoplasmas; Molecular biological study on genetic stability of the genome; Protein factors regulating proliferation and differentiation of normal and neoplastic cells; Studies on dose-radiation relationships for induction of chromosome abberations in stem-spermatogonia of three crab-eating monkey after low and high dose rate γ-irradiation; Risk estimation of radiation mutagenesis in man by using cultured mammalian cells; Effects of ionizing radiation on male germ cells of crabeating monkey; Movement and metabolism of radioactive particles in the respiratory tract; Studies on dosimetry for internally deposited alpha-emitters; Comparative toxicological studies on the effects of internal exposures; Studies on treatment of alpha-radioactive wastes; Methodological studies on the inhalation of radioactive aerosols; Removal of transuranic elements by DTPA. (A. Y.)

  11. Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project

    DEFF Research Database (Denmark)

    Birney, Ewan; Stamatoyannopoulos, John A; Dutta, Anindya

    2007-01-01

    We report the generation and analysis of functional data from multiple, diverse experiments performed on a targeted 1% of the human genome as part of the pilot phase of the ENCODE Project. These data have been further integrated and augmented by a number of evolutionary and computational analyses...

  12. Sequencing and characterizing the genome of Estrella lausannensis as an undergraduate project: training students and biological insights

    Directory of Open Access Journals (Sweden)

    Claire eBertelli

    2015-02-01

    Full Text Available With the widespread availability of high-throughput sequencing technologies, sequencing projects have become pervasive in the molecular life sciences. The huge bulk of data generated daily must be analyzed further by biologists with skills in bioinformatics and by embedded bioinformaticians, i.e., bioinformaticians integrated in wet lab research groups. Thus, students interested in molecular life sciences must be trained in the main steps of genomics: sequencing, assembly, annotation and analysis. To reach that goal, a practical course has been set up for master students at the University of Lausanne: the Sequence a genome class. At the beginning of the academic year, a few bacterial species whose genome is unknown are provided to the students, who sequence and assemble the genome(s and perform manual annotation. Here, we report the progress of the first class from September 2010 to June 2011 and the results obtained by seven master students who specifically assembled and annotated the genome of Estrella lausannensis, an obligate intracellular bacterium related to Chlamydia. The draft genome of Estrella is composed of 29 scaffolds encompassing 2,819,825 bp that encode for 2,233 putative proteins. Estrella also possesses a 9,136 bp plasmid that encodes for 14 genes, among which we found an integrase and a toxin/antitoxin module. Like all other members of the Chlamydiales order, Estrella possesses a highly conserved type III secretion system, considered as a key virulence factor. The annotation of the Estrella genome also allowed the characterization of the metabolic abilities of this strictly intracellular bacterium. Altogether, the students provided the scientific community with the Estrella genome sequence and a preliminary understanding of the biology of this recently-discovered bacterial genus, while learning to use cutting-edge technologies for sequencing and to perform bioinformatics analyses.

  13. How does sustainability certification affect the design process? Mapping final design projects at an architectural office

    DEFF Research Database (Denmark)

    Landgren, Mathilde; Jensen, Lotte Bjerregaard

    2017-01-01

    process and informing the industry of them. This has led to optimised design processes such as Integrated Energy Design, in which many decisions related to energy consumption and indoor climate are made in the early design stages. The current tendency is to use an expanded notion of sustainability......, derived from the sustainability certification system itself, and to apply it even in the early design process. This perspective emphasises all phases of the life cycle of a building. The goal of the present study was to map how a Danish architectural office approached sustainability in the projects......The context of the study is the very strict regulation of energy consumption for operating buildings in Denmark. It is difficult to meet the requirements by system optimisation in the final design phase, so recent research has focused on ways of meeting the target by adapting the whole design...

  14. Final report of the inter institutional project ININ-CNSNS 'Source Terms specific for the CNLV'

    International Nuclear Information System (INIS)

    Anaya M, R.A.

    1991-02-01

    The purpose of the project inter institutional ININ-CNSNS 'Source Terms Specifies for the CNLV' it is the one of implanting in the computer CYBER (CDC 180-830) of the ININ, the 'Source Term Code Package' (STCP) and to make the operation tests and corresponding operation using the data of the sample problem, for finally to liberate the package, all time that by means of the analysis of the results it is consider appropriate. In this report the results of the are presented simulation of the sequence 'Energy Losses external' (Station blackout) and 'Lost total of CA with failure of the RCIC and success of the HPCS' both with data of the Laguna Verde Central. (Author)

  15. Final Report: "Collaborative Project. Understanding the Chemical Processes That Affect Growth Rates of Freshly Nucleated Particles"

    Energy Technology Data Exchange (ETDEWEB)

    Smith, James N. [NCAR, Boulder, CO (United States); McMurry, Peter H. [NCAR, Boulder, CO (United States)

    2015-11-12

    This final technical report describes our research activities that have, as the ultimate goal, the development of a model that explains growth rates of freshly nucleated particles. The research activities, which combine field observations with laboratory experiments, explore the relationship between concentrations of gas-phase species that contribute to growth and the rates at which those species are taken up. We also describe measurements of the chemical composition of freshly nucleated particles in a variety of locales, as well as properties (especially hygroscopicity) that influence their effects on climate. Our measurements include a self-organized, DOE-ARM funded project at the Southern Great Plains site, the New Particle Formation Study (NPFS), which took place during spring 2013. NPFS data are available to the research community on the ARM data archive, providing a unique suite observations of trace gas and aerosols that are associated with the formation and growth of atmospheric aerosol particles.

  16. How do the Polytechnic Students Cope with the Difficulties in Composing Abstracts for Their Final Projects?

    Science.gov (United States)

    Niswatin, C.; Latief, M. A.; Suharyadi, S.

    2018-02-01

    This research aims to uncover the fact about engineering students in dealing with composing abstracts for their final projects. The research applies a descriptive qualitative quantitative design. The data were collected through questioners involving 104 engineering students, including the alumni at Politeknik Kota Malang, Indonesia. Furthermore, interviews were carried out to explain the details where necessary to support the primary data. It is found that the common problems faced by engineering students include 1) combining words into sentences, 2) identifying the most appropriate technical terms in engineering, and 3) applying grammar in context. To cope with those difficulties they demanded translation application machines, supported by peer-proofreaders. In addition, they considerably engaged personal tutoring with the lectures more than three times.

  17. Development of a criticality alarm system neutron detector: Final project report

    International Nuclear Information System (INIS)

    O'Dell, A.A.

    1989-05-01

    The primary objective of this project was to develop a prototype neutron detector for use in criticality alarm systems (CASs) at US Department of Energy (DOE) and contractor facilities wherever significant amounts of fissile material are processed or stored. Constraints placed on the design of the detector were that the overall size of the detector was to be as small as practical, the input voltage requirements were to be no more than 24 V, and that the gamma sensitivity would be as low as possible. Also, the detector should give dosimetric neutron response, and should have sufficient temporal capabilities to measure the entire range from fast (>1 ms) to slow (seconds to minutes) excursions, and sufficient dynamic range to measure from background to over 100 times background levels to insure proper activation of the Immediate Evacuation Alarm (IEA). Finally, the detector should insure rapid (<1 s) activation of the IEA in the event of a criticality excursion. 24 figs., 11 tabs

  18. Telephone Flat Geothermal Development Project Environmental Impact Statement Environmental Impact Report. Final: Comments and Responses to Comments

    Energy Technology Data Exchange (ETDEWEB)

    None

    1999-02-01

    This document is the Comments and Responses to Comments volume of the Final Environmental Impact Statement and Environmental Impact Report prepared for the proposed Telephone Flat Geothermal Development Project (Final EIS/EIR). This volume of the Final EIS/EIR provides copies of the written comments received on the Draft EIS/EIR and the leady agency responses to those comments in conformance with the requirements of the National Environmental Policy Act (NEPA) and the California Environmental Quality Act (CEQA).

  19. Harmony in Career Learning and Scholastic System (Project HI-CLASS). Final Evaluation Report 1992-93. OREA Report.

    Science.gov (United States)

    Duque, Diana L.

    Harmony in Career Learning and Scholastic System (Project HI-CLASS) was a Transitional Bilingual Education Title VII-funded program in its fifth and final year in 1992-93. The project offered instructional and support services to 641 students of limited English proficiency (LEP) at three sites, all of which had many immigrant students, in…

  20. Athlome Project Consortium: a concerted effort to discover genomic and other "omic" markers of athletic performance.

    Science.gov (United States)

    Pitsiladis, Yannis P; Tanaka, Masashi; Eynon, Nir; Bouchard, Claude; North, Kathryn N; Williams, Alun G; Collins, Malcolm; Moran, Colin N; Britton, Steven L; Fuku, Noriyuki; Ashley, Euan A; Klissouras, Vassilis; Lucia, Alejandro; Ahmetov, Ildus I; de Geus, Eco; Alsayrafi, Mohammed

    2016-03-01

    Despite numerous attempts to discover genetic variants associated with elite athletic performance, injury predisposition, and elite/world-class athletic status, there has been limited progress to date. Past reliance on candidate gene studies predominantly focusing on genotyping a limited number of single nucleotide polymorphisms or the insertion/deletion variants in small, often heterogeneous cohorts (i.e., made up of athletes of quite different sport specialties) have not generated the kind of results that could offer solid opportunities to bridge the gap between basic research in exercise sciences and deliverables in biomedicine. A retrospective view of genetic association studies with complex disease traits indicates that transition to hypothesis-free genome-wide approaches will be more fruitful. In studies of complex disease, it is well recognized that the magnitude of genetic association is often smaller than initially anticipated, and, as such, large sample sizes are required to identify the gene effects robustly. A symposium was held in Athens and on the Greek island of Santorini from 14-17 May 2015 to review the main findings in exercise genetics and genomics and to explore promising trends and possibilities. The symposium also offered a forum for the development of a position stand (the Santorini Declaration). Among the participants, many were involved in ongoing collaborative studies (e.g., ELITE, GAMES, Gene SMART, GENESIS, and POWERGENE). A consensus emerged among participants that it would be advantageous to bring together all current studies and those recently launched into one new large collaborative initiative, which was subsequently named the Athlome Project Consortium. Copyright © 2016 the American Physiological Society.

  1. Deep brain stimulation, brain maps and personalized medicine: lessons from the human genome project.

    Science.gov (United States)

    Fins, Joseph J; Shapiro, Zachary E

    2014-01-01

    Although the appellation of personalized medicine is generally attributed to advanced therapeutics in molecular medicine, deep brain stimulation (DBS) can also be so categorized. Like its medical counterpart, DBS is a highly personalized intervention that needs to be tailored to a patient's individual anatomy. And because of this, DBS like more conventional personalized medicine, can be highly specific where the object of care is an N = 1. But that is where the similarities end. Besides their differing medical and surgical provenances, these two varieties of personalized medicine have had strikingly different impacts. The molecular variant, though of a more recent vintage has thrived and is experiencing explosive growth, while DBS still struggles to find a sustainable therapeutic niche. Despite its promise, and success as a vetted treatment for drug resistant Parkinson's Disease, DBS has lagged in broadening its development, often encountering regulatory hurdles and financial barriers necessary to mount an adequate number of quality trials. In this paper we will consider why DBS-or better yet neuromodulation-has encountered these challenges and contrast this experience with the more successful advance of personalized medicine. We will suggest that personalized medicine and DBS's differential performance can be explained as a matter of timing and complexity. We believe that DBS has struggled because it has been a journey of scientific exploration conducted without a map. In contrast to molecular personalized medicine which followed the mapping of the human genome and the Human Genome Project, DBS preceded plans for the mapping of the human brain. We believe that this sequence has given personalized medicine a distinct advantage and that the fullest potential of DBS will be realized both as a cartographical or electrophysiological probe and as a modality of personalized medicine.

  2. ''Heat Transfer at the Mold-Metal Interface in Permanent Mold Casting of Aluminum Alloys'' Final Project Report; FINAL

    International Nuclear Information System (INIS)

    Pehlke, R. D.; Cookson, John M.; Shouwei Hao; Prasad Krishna; Bilkey, Kevin T.

    2001-01-01

    This project on heat transfer coefficients in metal permanent mold casting has been conducted in three areas. They are the theoretical study at the University of Michigan, the experimental investigation of squeeze casting at CMI-Tech Center (Now Hayes-Lemmerz Technical Center) and the experimental investigation of low pressure permanent mold casting at Amcast Automotive

  3. FINAL PROJECT REPORT - EVALUATION AND TESTING OF HTGR REACTOR BUILDING RESPONSE TO DEPRESSURIZATION ACCIDENTS

    Energy Technology Data Exchange (ETDEWEB)

    ALLIANCE LIMITED, NGNP INDUSTRY

    2017-07-25

    This report provides a description of the project, summarizes each phase of the project, and ends with project conclusions. In addition, the report contains a descriptive index of the technical reports generated during the course of the project.

  4. Surface and subsurface cleanup protocol for radionuclides, Gunnison, Colorado, UMTRA project processing site: Final

    International Nuclear Information System (INIS)

    1994-01-01

    Thorium 230 (Th-230) at the Gunnison, Colorado processing site will require remediation, however, a seasonally fluctuating groundwater table at the site significantly complicates conventional remedial action with respect to cleanup. Therefore, to effectively remediate the site with respect to Radium 226 (Ra-226) and Th-230, the following supplemental standard is proposed: In situ Ra-26 will be remediated to the EPA soil cleanup standards independent of groundwater considerations. In situ Th-230 concentrations will be remediated in the region above the encountered water table so the 1000-year projected Ra-226 concentration complies with the EPA soil cleanup concentration limits. If elevated Th-230 persists to the water table, an additional foot of excavation will be performed and the grid will be backfilled. Excavated grids will be backfilled to the final remedial action grade with clean cobbly soil. Final grid verification that is required below the water table will be performed by extracting and analyzing a single bulk soil sample with the bucket of a backhoe. Modeled surface radon flux values will be estimated and documented. A recommendation will be made that land records should be annotated to identify the presence of residual Th-230

  5. Final audit report of remedial action construction at the UMTRA Project, Grand Junction, Colorado, processing site

    International Nuclear Information System (INIS)

    1995-02-01

    This final audit report (FAR) for remedial action at the Grand Junction, Colorado, Uranium Mill Tailings Remedial Action (UMTRA) Project processing site consists of a summary of the radiological surveillances/ audits, the quality assurance (QA) in-process surveillances, and the QA final close-out inspection performed by the US Department of Energy (DOE) and Technical Assistance Contractor (TAC). The FAR also summarizes other surveillances performed by the US Nuclear Regulatory Commission (NRC). To summarize, a total of one finding and 127 observations were noted during DOE/TAC audit and surveillance activities. The NRC noted general site-related observations during the OSCRs. Follow-up to responses required from MK-Ferguson for the DOE/TAC finding and observations indicated that all issues related to the Grand Junction processing site were resolved and closed out to the DOE's satisfaction. The NRC OSCRs resulted in no issues related to the Grand Junction processing site requiring a response from MK-Ferguson

  6. KEY COMPARISON: Final report of EUROMET Project 696: pH determination of a phthalate buffer

    Science.gov (United States)

    Spitzer, Petra; Charlet, Philippe; Eberhard, Ralf; Karpov, Oleg V.; Philippe, Rachel; Rivier, Cedric; Maximov, Igor; Sudmeier, Uwe

    2005-01-01

    The EUROMET project 696, a trilateral comparison between PTB, Germany, LNE, France and VNIIFTRI, Russia was performed in order to demonstrate and document the capability of the participants to measure the pH of a phthalate buffer by the primary measurement procedure for pH. Good agreement of the reported results was observed. The sample was very similar to the one used in the comparison CCQM-K17. PTB acts as pilot laboratory in CCQM-K17 and in EUROMET 696. This comparison allows one to link the results obtained by LNE to the CCQM-K17 key comparison through the degree of equivalence of PTB. On the other hand, the discrepancy between measured pH values at the VNIIFTRI and PTB for the same type of buffer solution decreased, as compared with a bilateral comparison in 1997. Main text. To reach the main text of this paper, click on Final Report. The final report has been peer-reviewed and approved for publication by the CCQM, according to the provisions of the Mutual Recognition Arrangement (MRA).

  7. Rhipicephalus microplus strain Deutsch, whole genome shotgun sequencing project Version 2

    Science.gov (United States)

    The cattle tick, Rhipicephalus (Boophilus) microplus, has a genome over 2.4 times the size of the human genome, and with over 70% of repetitive DNA, this genome would prove very costly to sequence at today's prices and difficult to assemble and analyze. Cot filtration/selection techniques were used ...

  8. Final audit report of remedial action construction at the UMTRA Project Falls City, Texas, site

    International Nuclear Information System (INIS)

    1995-05-01

    This final audit report for the Falls City, Texas, Uranium Mill Tailings Remedial Action Project site summarizes the radiological audits and the quality assurance (QA) in-process surveillances, audits, and final close-out inspection performed by the U.S. Department of Energy (DOE) and Technical Assistance Contractor (TAC). It also summarizes U.S. Nuclear Regulatory Commission (NRC) surveillances. One radiological audit and three radiological surveillances were performed at the Falls City site. These surveillances and audit, which resulted in 31 observations, focused primarily on processing site activities and were performed on the following dates: 3-6 August 1992, 29-30 October 1992, 22-26 March 1993, and 1-3 November 1993. All outstanding radiological issues were closed out at the completion of the construction activities. Six QA in-process surveillances, which resulted in 71 observations, were performed at the Falls City site on the following dates: 22-24 July 1992, 23-25 November 1992, 17-19 May 1993, 16-18 August 1993, 13-15 October 1993, and 2-4 February 1994. All outstanding issues were closed out with the February surveillance on 3 March 1994. The DOE/TAC remedial action close-out inspections of the Falls City site, which resulted in 56 observations, were conducted 9-10 June 1994 and 26 July 1994. The inspections were closed out on 26 January 1995. The NRC performed three on-site construction reviews (OSCR), resulting in seven observations of remedial action construction activities that occurred during site visits. The OSCRs were performed 9 December 1992, 12 May 1993, and 25 October 1993. Since all audit and surveillance observations and recommendations have been closed out, this final audit report segment of the site certification process is complete

  9. Final audit report of remedial action construction at the UMTRA Project Ambrosia Lake, New Mexico, site

    International Nuclear Information System (INIS)

    1995-09-01

    The final audit report for remedial action at the Ambrosia Lake, New Mexico, Uranium Mill Tailings Remedial Action (UMTRA) Project site consists of a summary of the radiological surveillances/audits, quality assurance (QA) in-process surveillances, and a QA final closeout inspection performed by the US Department of Energy (DOE) and the Technical Assistance Contractor (TAC). One radiological surveillance and three radiological audits were performed at the Ambrosia Lake site. The surveillance was performed on 12--16 April 1993 (DOE, 1993d). The audits were performed on 26--29 July 1993 (DOE, 1993b); 21--23 March 1994 (DOE, 1994d); and 1--2 August 1994 (DOE, 1994d). The surveillance and audits resulted in 47 observations. Twelve of the observations raised DOE concerns that were resolved on site or through subsequent corrective action. All outstanding issues were satisfactorily closed out on 28 December 1994. The radiological surveillance and audits are discussed in this report. A total of seven QA in-process surveillances were performed at the Ambrosia Lake UMTRA site are discussed. The DOE/TAC Ambrosia Lake final remedial action close-out inspection was conducted on 26 July 1995 (DOE, 1995a). To summarize, a total of 155 observations were noted during DOE/TAC audit and surveillance activities. Follow-up to responses required from the RAC for the DOE/TAC surveillance and audit observations indicated that all issues related to the Ambrosia Lake site were resolved and closed to the satisfaction of the DOE

  10. Clean and efficient energy conversion processes (Cecon-project). Final report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-12-31

    The objectives of the work programme reported are the development and testing of two optimised energy conversion processes, both consisting of a radiant surface gas burner and a ceramic heat exchanger. The first sub-objective of the programme is related to industrial heating, drying and curing processes requireing low and medium heat fluxes. It is estimated that around one tenth of the total EC industrial energy use is associated with such processes. The majority of these processes currently use convection and conduction as the main heat transfer mechanisms and overall energy efficiencies are typically below 25%. For many drying and finishing processes (such as curing powder coatings and drying paints, varnishes, inks, and for the fabrication of paper and textiles), radiant heating can achieve much faster dyring rates and higher energy efficiency than convective heating. In the project new concepts of natural gas fired radiant heating have been investigated which would be much more efficient than the existing processes. One element of the programme was the evelopment of gas burners having enhanced radiant efficiencies. A second concerned the investigation of the safety of gas burners containing significant volumes of mixed gas and air. Finally the new gas burners were tested in combination with the high temperature heat exchanger to create highly efficient radiant heating systems. The second sub-objective concerned the development of a compact low cost heat exchanger capable of achieving high levels of heat recovery (up to 60%) which could be easily installed on industrial processes. This would make heat recovery a practical proposition on processes where existing heat recovery technology is currently not cost effective. The project will have an impact on industrial processes consuming around 80 MTOE of energy per year within EU countries (1 MTOE equals 41.8 PJ). The overall energy saving potential of the project is estimated to be around 22 MTOE which is around 10

  11. Participation in the IAEA Coordinated Research Project Fumex III: Final Report of AREVA NP

    International Nuclear Information System (INIS)

    2013-01-01

    After the Coordinated Research Project (CRP) FUMEXII, participants asked for a new exercise within an IAEA CRP. This CRP started in December 2008 in Vienna with the first Research Coordination Meeting (RCM). The CRP is titled ''Improvement of Computer Codes Used for Fuel Behaviour Simulation FUMEX III''. The object of FUMEX III were the improvement of fuel rod performance codes for modeling high burnup phenomena in modern fuel. This includes transient behavior, as well as mechanical interaction between pellet and cladding and, in progression to the FUMEX II exercise, fission gas release during various conditions (steady state, load follow, transient). AREVA NP agreed on participating in this exercise under the IAEA research agreement no. 15369 and expressed interest in the modeling of pelletclad mechanical interactions as well as fission gas release under steady state and transient conditions. In this exercise AREVA NP used its new global fuel rod code GALILEO, which is still under development (formerly known under the project name COPERNIC 3). During a Consultants Meeting potential topics and a proposed selection of cases have been prepared, which were discussed during the 1st Research Coordination Meeting (RCM) in Vienna in December 2008. During the discussions a number of additional cases motivated by the participants have been identified. Finally, a case table has been agreed upon, which included several cases for the different topics. Most of the cases have been based on the International Fuel Performance Experiments (IFPE) database, but additional cases have been provided during the exercise (e.g., the AREVA idealized case

  12. Final status of the salt repository project waste package program experimental database

    International Nuclear Information System (INIS)

    Thornton, B.M.; Reimus, P.W.

    1988-03-01

    This report describes the final status of the Salt Repository Project Waste Package Program Experimental Database. The data base serves as a clearinghouse for all data collected within the Waste Package Program (WPP) and its predecessor programs at Pacific Northwest Laboratory (PNL). The database was maintained using RS/1 database management software. Documented assurance that the entries in the database were consistent with experimental records was provided by having each experimentalist inspect the entries and signify that they were in agreement with the records. The inspection and signoff were done per PNL technical procedures. Data for which it was impossible to obtain the experimentalist's inspection and signature were segregated from the rest of the database, although they could still be accessed by WPP staff. The WPPED contains two groups of subdirectories. One group contains data taken prior to the installation of quality assurance procedures at PNL. The other group of subdirectories contains data taken under the NQA-1 procedures since their installation in April 1985. As part of closeout activities in the Salt Repository Project, the WPP database has been archived onto magnetic media. The data in the database are available by request on magnetic media or in hardcopy form. 2 refs

  13. Renewable electricity market developments in the European Union. Final Report of the ADMIRE REBUS project

    International Nuclear Information System (INIS)

    Uyterlinde, M.A.; Daniels, B.W.; De Noord, M.; De Vries, H.J.; De Zoeten - Dartenset, C.; Skytte, K.; Meibom, P.; Lescot, D.; Hoffmann, T.; Stronzik, M.; Gual, M.; Del Rio, P.; Hernandez, F.

    2003-10-01

    Which countries offer the best markets for renewables? Are present support policies sufficient to meet the EU (European Union) renewables target for 2010? Which renewable technologies will have the largest growth in the present decade? The ADMIRE REBUS project has addressed these questions by giving an outlook on the future of electricity from renewable energy sources. The ADMIRE REBUS project team has analysed the market barriers, support policies and potentials for renewable electricity production in Europe. For these analyses a new tool was developed that simulates the development of the European renewable electricity market under different policy scenarios. The report starts with describing the approach and key assumptions used in the analysis. Next, an overview is provided of EU legislation and different support policies for renewable energy. After a brief overview of the different challenges that an investor faces when investing in renewable energy technologies with respect to lead times, risks and transaction costs, several policy scenarios for the future are discussed. Next, the report presents ADMIRE REBUS model analyses of different policy strategies for meeting the targets stated in the EU Renewables Directive. The report continues the analysis of model results with presenting prospects for individual technologies and market prices under different scenarios. Next, case studies are presented for four different EU Member States. The analysis results are put into perspective by a sensitivity analysis. Finally, conclusions are drawn and recommendations are formulated based on the above

  14. Selected Area Fishery Evaluation Project Economic Analysis Study Final Report, Final Draft Revision 4: November 10, 2006.

    Energy Technology Data Exchange (ETDEWEB)

    Bonneville Power Administration; Washington Department of Fish and Wildlife; Oregon Department of Fish and Wildlife

    2006-11-01

    The purpose of this Study is to provide an economic review of current and proposed changes to the Select Area Fishery Evaluation Project (SAFE or Project). The Study results are the information requested in comments made on the Project by a joint review dated March 2005 by the Northwest Power and Conservation Council (NPCC) Independent Scientific Review Panel (ISRP) and Independent Economic Analysis Board (IEAB). North et al. (2006) addressed technical questions about operations and plans, and this report contains the response information for comments concerning Project economics. This report can be considered an economic feasibility review meeting guidelines for cost-effective analysis developed by the IEAB (2003). It also contains other economic measurement descriptions to illustrate the economic effects of SAFE. The SAFE is an expansion of a hatchery project (locally called the Clatsop Economic Development Council Fisheries Project or CEDC) started in 1977 that released an early run coho (COH) stock into the Youngs River. The Youngs River entrance to the Columbia River at River Mile 12 is called Youngs Bay, which is located near Astoria, Oregon. The purpose of the hatchery project was to provide increased fishing opportunities for the in-river commercial fishing gillnet fleet. Instead of just releasing fish at the hatchery, a small scale net pen acclimation project in Youngs Bay was tried in 1987. Hirose et al. (1998) found that 1991-1992 COH broodstock over-wintered at the net pens had double the smolt-to-adult return rate (SAR) of traditional hatchery release, less than one percent stray rates, and 99 percent fishery harvests. It was surmised that smolts from other Columbia River hatcheries could be hauled to the net pens for acclimation and release to take advantage of the SAR's and fishing rates. Proposals were tendered to Bonneville Power Administration (BPA) and other agencies to fund the expansion for using other hatcheries smolts and other off

  15. Final report- Links between persistent DNA damage, genome instability, and aging

    Energy Technology Data Exchange (ETDEWEB)

    Dynan, William S. [Emory Univ., Atlanta, GA (United States)

    2016-11-30

    The goal of the project was to determine whether high linear energy transfer (LET) space radiation produces the same or different effects as low doses of terrestrial (low-LET) radiation. The work used the Japanese medaka fish (Oryzias latipes) as a vertebrate model organism that can be maintained in large numbers at low cost for lifetime studies. To determine whether simulated space radiation produced the same or different effects as low doses of low-LET radiation, medaka embryos were irradiated at doses ranging from 0.1 to 9 Gray (Gy) of high-LET charged particle radiation (1000 MeV/nucleon 56-Fe ions) or 0.1 Gy to 27 Gy of low-LET gamma-rays. To examine the effect of irradiation on potential biomarkers, the population was sampled at intervals from 8 to 28 months post-irradiation and liver tissue was subjected to histological and molecular analysis. Charged particle radiation and aging contributed synergistically to accumulation of lipid oxidation products, which are a marker of chronic oxidative stress. This was mirrored by a decline in mRNA encoding the transcriptional activator PPARGC1A, which is required for mitochondrial maintenance and for defense against oxidative stress. Additionally, mitochondria had an elongated and enlarged ultrastructure. Depending on the endpoint, effects of gamma-rays in the same dose range were either lesser or not detected. Together, results indicate that a single exposure to high-LET, but not low-LET radiation, early in life, leads to increased oxidative stress throughout the normal lifespan of the individual.

  16. Project GICC-Rhone Final report of part I; Projet GICC-Rhone Rapport final de tranche I

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2002-12-15

    The project aims to give an evaluation of the impacts on the french Rhone basin, of the climatic change resulting of a double of the CO{sub 2} content in the atmosphere (possible in 2050). This report gives an evaluation of the researches progress. It describes the topic of the part I, the hydrological simulations realized and the analysis of the hydrological impacts. It provides also recommendations for the part II. The following topics are presented: the objectives of the project; the data and the atmospheric scenari construction methods on the Rhone basin under the climatic change; the used hydrological models; the results analysis in terms of hydrogeological impacts; the limits of the approach; and a bibliography. (A.L.B.)

  17. Lawrence Livermore National Laboratory- Completing the Human Genome Project and Triggering Nearly $1 Trillion in U.S. Economic Activity

    Energy Technology Data Exchange (ETDEWEB)

    Stewart, Jeffrey S. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2015-07-28

    The success of the Human Genome project is already nearing $1 Trillion dollars of U.S. economic activity. Lawrence Livermore National Laboratory (LLNL) was a co-leader in one of the biggest biological research effort in history, sequencing the Human Genome Project. This ambitious research effort set out to sequence the approximately 3 billion nucleotides in the human genome, an effort many thought was nearly impossible. Deoxyribonucleic acid (DNA) was discovered in 1869, and by 1943 came the discovery that DNA was a molecule that encodes the genetic instructions used in the development and functioning of living organisms and many viruses. To make full use of the information, scientists needed to first sequence the billions of nucleotides to begin linking them to genetic traits and illnesses, and eventually more effective treatments. New medical discoveries and improved agriculture productivity were some of the expected benefits. While the potential benefits were vast, the timeline (over a decade) and cost ($3.8 Billion) exceeded what the private sector would normally attempt, especially when this would only be the first phase toward the path to new discoveries and market opportunities. The Department of Energy believed its best research laboratories could meet this Grand Challenge and soon convinced the National Institute of Health to formally propose the Human Genome project to the federal government. The U.S. government accepted the risk and challenge to potentially create new healthcare and food discoveries that could benefit the world and the U.S. Industry.

  18. GENRE ANALYSIS OF THE ENGLISH FINAL PROJECT ABSTRACTS WRITTEN BY THE STUDENTS OF ENGLISH EDUCATION DEPARTMENT OF IKIP PGRI SEMARANG

    Directory of Open Access Journals (Sweden)

    Wiyaka Wiyaka

    2010-12-01

    Full Text Available This study is specifically focused on the student final project abstract based on genre analysis which covers the study of the generic structure and the linguistic features. The statements of the study are: (1. How do the students of English Education Department of IKIP PGRI Semarang realize the generic structure in their final project abstracts (2. How do they realize the linguistic features in their final project abstracts, and (3. What is the contribution of the result of the study to the English Education Program of IKIP PGRI Semarang. The main purpose of this study is to find out the generic structure and linguistic features of the final project abstracts and analyze the contribution of this study to the English Department. This study applies the descriptive qualitative method. The object of this study is the final project abstracts written by English Education Department students of ‘IKIP PGRI Semarang’. The total of 10 final projects formed the data of this study. The data of the study were analyzed using the genre analysis approach. The first step of data analysis was identifying the Moves which was done by using Linguistic evidence and understanding the texts. The finding shows that only some of the final project abstracts made by the students of IKIP PGRI applied the five Moves. It is found that two Moves are applied in all abstracts, they are Purpose and Method Moves (100%. Situating the research is used in five abstracts (50%. Meanwhile the third move that is the Result Move used in eight abstracts (80%. The Conclusion Move found in five abstracts (50%. The result of the analysis showed that two personal pronouns were found in the final project abstracts. Personal pronouns such as ‘the writer’ and ‘the researcher’ were found in all of the abstracts. Personal pronoun ‘she’ was found in one abstract. Finally, there are only five expressions of hedges that are used in the final project abstracts, they

  19. US Department of Energy Grand Junction Projects Office Remedial Action Project. Final report of the decontamination and decommissioning of Building 52 at the Grand Junction Projects Office Facility

    International Nuclear Information System (INIS)

    Krabacher, J.E.

    1996-08-01

    The U.S. Department of Energy (DOE) Grand Junction Projects Office (GJPO) occupies a 61.7-acre facility along the Gunnison River near Grand Junction, Colorado. This site was contaminated with uranium ore and mill tailings during uranium refining activities of the Manhattan Engineer District and during pilot milling experiments conducted for the U.S. Atomic Energy Commission's domestic uranium procurement program. The DOE Defense Decontamination and Decommissioning Program established the GJPO Remedial Action Project to clean up and restore the facility lands, improvements, and the underlying aquifer. The site contractor for the facility, Rust Geotech, also was the remedial action contractor. Building 52 was found to be radiologically contaminated and was demolished in 1994. The soil area within the footprint of the building has been remediated in accordance with the identified standards and the area can be released for unlimited exposure and unrestricted use. This document was prepared in response to a DOE request for an individual final report for each contaminated GJPO building

  20. Status Review of Wildlife Mitigation, Columbia Basin Hydroelectric Projects, Washington Facilities (Intrastate) Final Report.

    Energy Technology Data Exchange (ETDEWEB)

    Howerton, Jack

    1984-11-01

    This report was prepared for BPA in fulfillment of section 1004 (b)(1) of the Pacific Northwest Electric Power Planning and Conservation Act of 1980, to review the status of past, present, and proposed future wildlife planning and mitigation program at existing hydroelectric projects in the Columbia River Basin. The project evaluations will form the basis for determining any needed remedial measures or additional project analysis. Projects addressed are: Merwin Dam; Swift Project; Yale Project; Cowlitz River; Boundary Dam; Box Canyon Dam; Lake Chelan; Condit Project; Enloe Project; Spokane River; Tumwater and Dryden Dam; Yakima; and Naches Project.