WorldWideScience

Sample records for genetics research program

  1. Applications of genetic programming in cancer research.

    Science.gov (United States)

    Worzel, William P; Yu, Jianjun; Almal, Arpit A; Chinnaiyan, Arul M

    2009-02-01

    The theory of Darwinian evolution is the fundamental keystones of modern biology. Late in the last century, computer scientists began adapting its principles, in particular natural selection, to complex computational challenges, leading to the emergence of evolutionary algorithms. The conceptual model of selective pressure and recombination in evolutionary algorithms allow scientists to efficiently search high dimensional space for solutions to complex problems. In the last decade, genetic programming has been developed and extensively applied for analysis of molecular data to classify cancer subtypes and characterize the mechanisms of cancer pathogenesis and development. This article reviews current successes using genetic programming and discusses its potential impact in cancer research and treatment in the near future.

  2. Mendelian Genetics: Paradigm, Conjecture, or Research Program.

    Science.gov (United States)

    Oldham, V.; Brouwer, W.

    1984-01-01

    Applies Kuhn's model of the structure of scientific revolutions, Popper's hypothetic-deductive model of science, and Lakatos' methodology of competing research programs to a historical biological episode. Suggests using Kuhn's model (emphasizing the nonrational basis of science) and Popper's model (emphasizing the rational basis of science) in…

  3. Linear genetic programming

    CERN Document Server

    Brameier, Markus

    2007-01-01

    Presents a variant of Genetic Programming that evolves imperative computer programs as linear sequences of instructions, in contrast to the more traditional functional expressions or syntax trees. This book serves as a reference for researchers, but also contains sufficient introduction for students and those who are new to the field

  4. Genetic programming in microorganisms

    Energy Technology Data Exchange (ETDEWEB)

    Hopwood, D A

    1981-11-01

    Formerly, when microbiologists had only existing organisms at their disposal whose characteristics could only be changed randomly by genetic experiments, they used to dream of programmed genetic changes. This dream has come true with modern genetic engineering.

  5. Applications of Genetic Programming

    DEFF Research Database (Denmark)

    Gaunholt, Hans; Toma, Laura

    1996-01-01

    In this report a study of genetic programming (GP) has been performed with respect to a number of applications such as Symbolic function regression, Solving Symbolic Differential Equations, Image encoding, the ant problem etc.......In this report a study of genetic programming (GP) has been performed with respect to a number of applications such as Symbolic function regression, Solving Symbolic Differential Equations, Image encoding, the ant problem etc....

  6. Research on non-uniform strain profile reconstruction along fiber Bragg grating via genetic programming algorithm and interrelated experimental verification

    Science.gov (United States)

    Zheng, Shijie; Zhang, Nan; Xia, Yanjun; Wang, Hongtao

    2014-03-01

    A new heuristic strategy for the non-uniform strain profile reconstruction along Fiber Bragg Gratings is proposed in this paper, which is based on the modified transfer matrix and Genetic Programming(GP) algorithm. The present method uses Genetic Programming to determine the applied strain field as a function of position along the fiber length. The structures that undergo adaptation in genetic programming are hierarchical structures which are different from that of conventional genetic algorithm operating on strings. GP regress the strain profile function which matches the 'measured' spectrum best and makes space resolution of strain reconstruction arbitrarily high, or even infinite. This paper also presents an experimental verification of the reconstruction of non-homogeneous strain fields using GP. The results are compared with numerical calculations of finite element method. Both the simulation examples and experimental results demonstrate that Genetic Programming can effectively reconstruct continuous profile expression along the whole FBG, and greatly improves its computational efficiency and accuracy.

  7. Genetic programming theory and practice XII

    CERN Document Server

    Riolo, Rick; Kotanchek, Mark

    2015-01-01

    These contributions, written by the foremost international researchers and practitioners of Genetic Programming (GP), explore the synergy between theoretical and empirical results on real-world problems, producing a comprehensive view of the state of the art in GP. Topics in this volume include: gene expression regulation, novel genetic models for glaucoma, inheritable epigenetics, combinators in genetic programming, sequential symbolic regression, system dynamics, sliding window symbolic regression, large feature problems, alignment in the error space, HUMIE winners, Boolean multiplexer funct

  8. Marine biosurfaces research program

    Science.gov (United States)

    The Office of Naval Research (ONR) of the U.S. Navy is starting a basic research program to address the initial events that control colonization of surfaces by organisms in marine environments. The program “arises from the Navy's need to understand and ultimately control biofouling and biocorrosion in marine environments,” according to a Navy announcement.The program, “Biological Processes Controlling Surface Modification in the Marine Environment,” will emphasize the application of in situ techniques and modern molecular biological, biochemical, and biophysical approaches; it will also encourage the development of interdisciplinary projects. Specific areas of interest include sensing and response to environmental surface (physiology/physical chemistry), factors controlling movement to and retention at surfaces (behavior/hydrodynamics), genetic regulation of attachment (molecular genetics), and mechanisms of attachment (biochemistry/surface chemistry).

  9. Scientific discovery using genetic programming

    DEFF Research Database (Denmark)

    Keijzer, Maarten

    2001-01-01

    programming paradigm. The induction of mathematical expressions based on data is called symbolic regression. In this work, genetic programming is extended to not just fit the data i.e., get the numbers right, but also to get the dimensions right. For this units of measurement are used. The main contribution......Genetic Programming is capable of automatically inducing symbolic computer programs on the basis of a set of examples or their performance in a simulation. Mathematical expressions are a well-defined subset of symbolic computer programs and are also suitable for optimization using the genetic...... in this work can be summarized as: The symbolic expressions produced by genetic programming can be made suitable for analysis and interpretation by using units of measurements to guide or restrict the search. To achieve this, the following has been accomplished: A standard genetic programming system...

  10. Genetic screening: programs, principles, and research--thirty years later. Reviewing the recommendations of the Committee for the Study of Inborn Errors of Metabolism (SIEM).

    Science.gov (United States)

    Simopoulos, A P

    2009-01-01

    Screening programs for genetic diseases and characteristics have multiplied in the last 50 years. 'Genetic Screening: Programs, Principles, and Research' is the report of the Committee for the Study of Inborn Errors of Metabolism (SIEM Committee) commissioned by the Division of Medical Sciences of the National Research Council at the National Academy of Sciences in Washington, DC, published in 1975. The report is considered a classic in the field worldwide, therefore it was thought appropriate 30 years later to present the Committee's modus operandi and bring the Committee's recommendations to the attention of those involved in genetics, including organizational, educational, legal, and research aspects of genetic screening. The Committee's report anticipated many of the legal, ethical, economic, social, medical, and policy aspects of genetic screening. The recommendations are current, and future committees should be familiar with them. In 1975 the Committee stated: 'As new screening tests are devised, they should be carefully reviewed. If the experimental rate of discovery of new genetic characteristics means an accelerating rate of appearance of new screening tests, now is the time to develop the medical and social apparatus to accommodate what later on may otherwise turn out to be unmanageable growth.' What a prophetic statement that was. If the Committee's recommendations had been implemented on time, there would be today a federal agency in existence, responsive and responsible to carry out the programs and support research on various aspects of genetic screening, including implementation of a federal law that protects consumers from discrimination by their employers and the insurance industry on the basis of genetic information. Copyright 2008 S. Karger AG, Basel.

  11. Research Program Overview

    Science.gov (United States)

    PEER logo Pacific Earthquake Engineering Research Center home about peer news events research products laboratories publications nisee b.i.p. members education FAQs links research Research Program Overview Tall Buildings Initiative Transportation Research Program Lifelines Program Concrete Grand

  12. Genetics as a modernization program: biological research at the Kaiser Wilhelm Institutes and the political economy of the Nazi State.

    Science.gov (United States)

    Gausemeier, Bernd

    2010-01-01

    During the Third Reich, the biological institutes of the Kaiser Wilhelm Society (KWG, Kaiser-Wilhelm-Gesellschaft) underwent a substantial reorganization and modernization. This paper discusses the development of projects in the fields of biochemical genetics, virus research, radiation genetics, and plant genetics that were initiated in those years. These cases exemplify, on the one hand, the political conditions for biological research in the Nazi state. They highlight how leading scientists advanced their projects by building close ties with politicians and science-funding organizations and companies. On the other hand, the study examines how the contents of research were shaped by, and how they contributed to, the aims and needs of the political economy of the Nazi system. This paper therefore aims not only to highlight basic aspects of scientific development under Nazism, but also to provide general insights into the structure of the Third Reich and the dynamics of its war economy.

  13. Behavioral program synthesis with genetic programming

    CERN Document Server

    Krawiec, Krzysztof

    2016-01-01

    Genetic programming (GP) is a popular heuristic methodology of program synthesis with origins in evolutionary computation. In this generate-and-test approach, candidate programs are iteratively produced and evaluated. The latter involves running programs on tests, where they exhibit complex behaviors reflected in changes of variables, registers, or memory. That behavior not only ultimately determines program output, but may also reveal its `hidden qualities' and important characteristics of the considered synthesis problem. However, the conventional GP is oblivious to most of that information and usually cares only about the number of tests passed by a program. This `evaluation bottleneck' leaves search algorithm underinformed about the actual and potential qualities of candidate programs. This book proposes behavioral program synthesis, a conceptual framework that opens GP to detailed information on program behavior in order to make program synthesis more efficient. Several existing and novel mechanisms subs...

  14. Contemporary Genetics for Gender Researchers: Not Your Grandma's Genetics Anymore

    Science.gov (United States)

    Salk, Rachel H.; Hyde, Janet S.

    2012-01-01

    Over the past century, much of genetics was deterministic, and feminist researchers framed justified criticisms of genetics research. However, over the past two decades, genetics research has evolved remarkably and has moved far from earlier deterministic approaches. Our article provides a brief primer on modern genetics, emphasizing contemporary…

  15. Genetic Network Programming with Reconstructed Individuals

    Science.gov (United States)

    Ye, Fengming; Mabu, Shingo; Wang, Lutao; Eto, Shinji; Hirasawa, Kotaro

    A lot of research on evolutionary computation has been done and some significant classical methods such as Genetic Algorithm (GA), Genetic Programming (GP), Evolutionary Programming (EP), and Evolution Strategies (ES) have been studied. Recently, a new approach named Genetic Network Programming (GNP) has been proposed. GNP can evolve itself and find the optimal solution. It is based on the idea of Genetic Algorithm and uses the data structure of directed graphs. Many papers have demonstrated that GNP can deal with complex problems in the dynamic environments very efficiently and effectively. As a result, recently, GNP is getting more and more attentions and is used in many different areas such as data mining, extracting trading rules of stock markets, elevator supervised control systems, etc., and GNP has obtained some outstanding results. Focusing on the GNP's distinguished expression ability of the graph structure, this paper proposes a method named Genetic Network Programming with Reconstructed Individuals (GNP-RI). The aim of GNP-RI is to balance the exploitation and exploration of GNP, that is, to strengthen the exploitation ability by using the exploited information extensively during the evolution process of GNP and finally obtain better performances than that of GNP. In the proposed method, the worse individuals are reconstructed and enhanced by the elite information before undergoing genetic operations (mutation and crossover). The enhancement of worse individuals mimics the maturing phenomenon in nature, where bad individuals can become smarter after receiving a good education. In this paper, GNP-RI is applied to the tile-world problem which is an excellent bench mark for evaluating the proposed architecture. The performance of GNP-RI is compared with that of the conventional GNP. The simulation results show some advantages of GNP-RI demonstrating its superiority over the conventional GNPs.

  16. Genetic programming theory and practice X

    CERN Document Server

    Riolo, Rick; Ritchie, Marylyn D; Moore, Jason H

    2013-01-01

    These contributions, written by the foremost international researchers and practitioners of Genetic Programming (GP), explore the synergy between theoretical and empirical results on real-world problems, producing a comprehensive view of the state of the art in GP. Topics in this volume include: evolutionary constraints, relaxation of selection mechanisms, diversity preservation strategies, flexing fitness evaluation, evolution in dynamic environments, multi-objective and multi-modal selection, foundations of evolvability, evolvable and adaptive evolutionary operators, foundation of  injecting

  17. Energy research program 83

    International Nuclear Information System (INIS)

    1983-01-01

    The energy research program 83 (EFP-83) is prepared by the Danish Ministry of Energy in order to continue the extension of the Danish energy research and development started through the former Trade Ministry's programs EM-1 (1976) and EM-2 (1978), and the Ministry of Energy's programs EFP-80, EFP-81 and EFP-82. The new program is a continuation of the activities in the period 1983-85 with a total budget of 111 mio. DKK. The program gives a brief description of background, principles, organization and financing, and a detailed description of each research area. (ln)

  18. Energy research program 85

    International Nuclear Information System (INIS)

    1985-01-01

    The energy research program 85 (EFP-85) is prepared by the Danish Ministry of Energy in order to continue the extension of the Danish energy research and development started through the former Trade Ministry's programs EM-1 (1976) and EM-2 (1978), and Ministry of Energy's programs EFP-80, EFP-81, EFP-82, EFP-83, and EFP-84. The new program is a continuation of the activities in the period 1985-87 with a total budget of 110 mio. DKK. The program gives a brief description of background, principles, organization and financing, and a detailed description of each research area. (ln)

  19. Energy research program 82

    International Nuclear Information System (INIS)

    1982-01-01

    The energy research program 82 (EFP-82) is prepared by the Danish ministry of energy in order to continue the extension of the Danish energy research and development started through the former trade ministry's programs EM-1 (1976) and EM-2 (1978), and the energy ministry's programs EFP-80 and EFP-81. The new program is a continuation of the activities in the period 1982-84 with a total budget of 100 mio.Dkr. The program gives a brief description of background, principles, organization and financing, and a detailed description of each research area. (BP)

  20. Energy research program 86

    International Nuclear Information System (INIS)

    1986-01-01

    The energy research program 86 (EFP-86) is prepared by the Danish Ministry of Energy in order to continue the extension of the Danish energy research and development started through the former Trade Ministry's programs EM-1 (1976) and EM-2 (1978), and the Ministry of Energy's programs EFP-80, EFP-81, EFP-82, EFP-83, EFP-84, and EFP-85. The new program is a continuation of the activities in the period 1986-88 with a total budget of 116 mio. DKK. The program gives a brief description of background, principles, organization and financing, and a detailed description of each research area. (ln)

  1. Energy research program 84

    International Nuclear Information System (INIS)

    1984-01-01

    The energy research program 84 (EFP-84) is prepared by the Danish Ministry of Energy in order to continue the extension of the Danish energy research and development started through the former Trade Ministry's programs EM-1 (1976) and EM-2 (1978), and the Ministry of Energy's programs EFP-80, EFP-81, EFP-82 and EFP-83. The new program is a continuation of the activities in the period 1984-86 with a total budget of 112 mio. DKK. The program gives a brief description of background, principles, organization and financing, and a detailed description of each research area. (ln)

  2. Epidemiology & Genomics Research Program

    Science.gov (United States)

    The Epidemiology and Genomics Research Program, in the National Cancer Institute's Division of Cancer Control and Population Sciences, funds research in human populations to understand the determinants of cancer occurrence and outcomes.

  3. Energy research program 80

    International Nuclear Information System (INIS)

    1980-01-01

    The energy research program 80 contains an extension of the activities for the period 1980-82 within a budget of 100 mio.kr., that are a part of the goverment's employment plan for 1980. The research program is based on a number of project proposals, that have been collected, analysed, and supplemented in October-November 1979. This report consists of two parts. Part 1: a survey of the program, with a brief description of the background, principles, organization and financing. Part 2: Detailed description of the different research programs. (LN)

  4. Piping research program plan

    International Nuclear Information System (INIS)

    1988-09-01

    This document presents the piping research program plan for the Structural and Seismic Engineering Branch and the Materials Engineering Branch of the Division of Engineering, Office of Nuclear Regulatory Research. The plan describes the research to be performed in the areas of piping design criteria, environmentally assisted cracking, pipe fracture, and leak detection and leak rate estimation. The piping research program addresses the regulatory issues regarding piping design and piping integrity facing the NRC today and in the foreseeable future. The plan discusses the regulatory issues and needs for the research, the objectives, key aspects, and schedule for each research project, or group of projects focussing of a specific topic, and, finally, the integration of the research areas into the regulatory process is described. The plan presents a snap-shot of the piping research program as it exists today. However, the program plan will change as the regulatory issues and needs change. Consequently, this document will be revised on a bi-annual basis to reflect the changes in the piping research program. (author)

  5. Cancer Genetics and Signaling | Center for Cancer Research

    Science.gov (United States)

    The Cancer, Genetics, and Signaling (CGS) Group at the National Cancer Institute at Frederick  offers a competitive postdoctoral training and mentoring program focusing on molecular and genetic aspects of cancer. The CGS Fellows Program is designed to attract and train exceptional postdoctoral fellows interested in pursuing independent research career tracks. CGS Fellows participate in a structured mentoring program designed for scientific and career development and transition to independent positions.

  6. Fermilab Research Program Workbook

    International Nuclear Information System (INIS)

    Rubinstein, R.

    1984-05-01

    The Fermilab Research Program Workbook has been published annually for the past several years to assist the Physics Advisory Committee in the yearly program review conducted during its summer meeting. While this is still a major aim, it is hoped that the Workbook will also prove useful to others seeking information on the current status of Fermilab experiments and the properties of beams at the Laboratory. In addition, short summaries of approved experiments are also included

  7. Acquisition Research Program Homepage

    OpenAIRE

    2015-01-01

    Includes an image of the main page on this date and compressed file containing additional web pages. Established in 2003, Naval Postgraduate School’s (NPS) Acquisition Research Program provides leadership in innovation, creative problem solving and an ongoing dialogue, contributing to the evolution of Department of Defense acquisition strategies.

  8. Controlled thermonuclear research program

    International Nuclear Information System (INIS)

    Anon.

    1976-01-01

    The Plasma Physics and Controlled-Fusion Research Program at the Lawrence Berkeley Laboratory is divided into five projects: Plasma Production and Heating Experiments, Plasma Theory, Atomic Physics Studies, the Tormac Project, and Neutral-Beam Development and Technology listed in order of increasing magnitude, as regards manpower and budget. Some cross sections and yields are shown in atomic physics

  9. Advanced maintenance research programs

    International Nuclear Information System (INIS)

    Marston, T.U.; Gelhaus, F.; Burke, R.

    1985-01-01

    The purpose of this paper is to provide the reader with an idea of the advanced maintenance research program at the Electric Power Research Institute (EPRI). A brief description of the maintenance-related activities is provided as a foundation for the advanced maintenance research projects. The projects can be divided into maintenance planning, preventive maintenance program development and implementation, predictive (or conditional) maintenance, and innovative maintenance techniques. The projects include hardware and software development, human factors considerations, and technology promotion and implementation. The advanced concepts include: the incorporation of artificial intelligence into outage planning; turbine and pump maintenance; rotating equipment monitoring and diagnostics with the aid of expert systems; and the development of mobile robots for nuclear power plant maintenance

  10. Hybrid of Genetic Programming with PBIL

    International Nuclear Information System (INIS)

    Caldas, Gustavo Henrique Flores; Schirru, Roberto

    2005-01-01

    Genetic programming and PBIL (Population-Based Incremental Learning) are evolutionary algorithms that have found applications in several fields of application. The Genetic Programming searches a solution allowing that the individuals of a population modify, mainly, its structures. The PBIL, on the other hand, works with individuals of fixed structure and is particularly successful in finding numerical solutions. There are problems where the simultaneous adjustment of the structure and numerical constants in a solution is essential. The Symbolic Regression is an example where both the form and the constants of a mathematical expression must be found. Although the traditional Genetic Programming is capable to solve this problem by itself, it is interesting to explore a cooperation with the PBIL, allowing each algorithm to do only that they do best: the Genetic Programming tries to find a structure while the PBIL adjust the constants that will be enclosed in the structure. In this work, the benchmark 'the sextic polynomial regression problem' is used to compare some traditional techniques of Genetic Programming with the proposed Hybrid of Genetic Programming with PBIL. The results are presented and discussed. (author)

  11. RESEARCH NOTE Molecular genetic analysis of consanguineous ...

    Indian Academy of Sciences (India)

    Navya

    Molecular genetic analysis of consanguineous families with primary microcephaly ... Translational Research Institute, Academic Health System, Hamad Medical ..... bridging the gap between homozygosity mapping and deep sequencing.

  12. Sandia Combustion Research Program

    Energy Technology Data Exchange (ETDEWEB)

    Johnston, S.C.; Palmer, R.E.; Montana, C.A. (eds.)

    1988-01-01

    During the late 1970s, in response to a national energy crisis, Sandia proposed to the US Department of Energy (DOE) a new, ambitious program in combustion research. Shortly thereafter, the Combustion Research Facility (CRF) was established at Sandia's Livermore location. Designated a ''user facility,'' the charter of the CRF was to develop and maintain special-purpose resources to support a nationwide initiative-involving US inventories, industry, and national laboratories--to improve our understanding and control of combustion. This report includes descriptions several research projects which have been simulated by working groups and involve the on-site participation of industry scientists. DOE's Industry Technology Fellowship program, supported through the Office of Energy Research, has been instrumental in the success of some of these joint efforts. The remainder of this report presents results of calendar year 1988, separated thematically into eleven categories. Referred journal articles appearing in print during 1988 and selected other publications are included at the end of Section 11. Our traditional'' research activities--combustion chemistry, reacting flows, diagnostics, engine and coal combustion--have been supplemented by a new effort aimed at understanding combustion-related issues in the management of toxic and hazardous materials.

  13. NRL HIFAR research program

    International Nuclear Information System (INIS)

    1989-01-01

    The use of a beam of heavy ions to ignite a thermonuclear pellet places severe constraints on beam emittance throughout the accelerator system. Nonlinearities which occur during beam transport, acceleration, and focusing, can cause emittance growth which limits spot intensity. Because of the high beam intensities required to achieve ignition, details of the self-consistent evolution of nonlinear space charge forces are generally important in this process. Computer simulations have, in turn, become an important tool in examining beam dynamics in this nonlinear regime. The Naval Research Laboratory HIFAR research program has been a major contributor to the successful use of numerical simulation to understand the detailed mechanisms by which space charge nonlinearities can contribute to emittance growth and the dilution of beam intensity. This program has been conducted in close cooperation with LLNL and LBL personnel to maximize support for those programs. Codes developed at NRL have been extensively shared and models developed at the other laboratories have been incorporated in the NRL codes. Because of the collaborative nature of much of the work over the past year, which has emphasized the development of numerical tools and techniques for general use, progress has generally resulted from shared efforts. The work, as reported here, emphasizes those contributions which can be attributed primarily to the NRL effort

  14. Fermilab research program workbook

    International Nuclear Information System (INIS)

    Rubinstein, R.

    1983-05-01

    The Fermilab Research Program Workbook has been produced annually for the past several years, with the original motivation of assisting the Physics Advisory Committee in its yearly program review conducted during its summer meeting. While this is still the primary goal, the Workbook is increasingly used by others needing information on the current status of Fermilab experiments, properties of beams, and short summaries of approved experiments. At the present time, considerable changes are taking place in the facilities at Fermilab. We have come to the end of the physics program using the 400 GeV Main Ring, which is now relegated to be just an injector for the soon-to-be commissioned Tevatron. In addition, the experimental areas are in the midst of a several-year program of upgrading to 1000 GeV capability. Several new beam lines will be built in the next few years; some indications can be given of their properties, although with the caveat that designs for some are by no means final. Already there is considerable activity leading to experiments studying anti p p collisions at √s = 2000 GeV

  15. HTGR safety research program

    International Nuclear Information System (INIS)

    Barsell, A.W.; Olsen, B.E.; Silady, F.A.

    1981-01-01

    An HTGR safety research program is being performed supporting and guided in priorities by the AIPA Probabilistic Risk Study. Analytical and experimental studies have been conducted in four general areas where modeling or data assumptions contribute to large uncertainties in the consequence assessments and thus, in the risk assessment for key core heat-up accident scenarios. Experimental data have been obtained on time-dependent release of fission products from the fuel particles, and plateout characteristics of condensible fission products in the primary circuit. Potential failure modes of primarily top head PCRV components as well as concrete degradation processes have been analyzed using a series of newly developed models and interlinked computer programs. Containment phenomena, including fission product deposition and potential flammability of liberated combustible gases have been studied analytically. Lastly, the behaviour of boron control material in the core and reactor subcriticality during core heatup have been examined analytically. Research in these areas has formed the basis for consequence updates in GA-A15000. Systematic derivation of future safety research priorities is also discussed. (author)

  16. Base Research Program

    Energy Technology Data Exchange (ETDEWEB)

    Everett Sondreal; John Hendrikson

    2009-03-31

    In June 2009, the Energy & Environmental Research Center (EERC) completed 11 years of research under the U.S. Department of Energy (DOE) Base Cooperative Agreement No. DE-FC26-98FT40320 funded through the Office of Fossil Energy (OFE) and administered at the National Energy Technology Laboratory (NETL). A wide range of diverse research activities were performed under annual program plans approved by NETL in seven major task areas: (1) resource characterization and waste management, (2) air quality assessment and control, (3) advanced power systems, (4) advanced fuel forms, (5) value-added coproducts, (6) advanced materials, and (7) strategic studies. This report summarizes results of the 67 research subtasks and an additional 50 strategic studies. Selected highlights in the executive summary illustrate the contribution of the research to the energy industry in areas not adequately addressed by the private sector alone. During the period of performance of the agreement, concerns have mounted over the impact of carbon emissions on climate change, and new programs have been initiated by DOE to ensure that fossil fuel resources along with renewable resources can continue to supply the nation's transportation fuel and electric power. The agreement has addressed DOE goals for reductions in CO{sub 2} emissions through efficiency, capture, and sequestration while expanding the supply and use of domestic energy resources for energy security. It has further contributed to goals for near-zero emissions from highly efficient coal-fired power plants; environmental control capabilities for SO{sub 2}, NO{sub x}, fine respirable particulate (PM{sub 2.5}), and mercury; alternative transportation fuels including liquid synfuels and hydrogen; and synergistic integration of fossil and renewable resources (e.g., wind-, biomass-, and coal-based electrical generation).

  17. Jointly Sponsored Research Program

    Energy Technology Data Exchange (ETDEWEB)

    Everett A. Sondreal; John G. Hendrikson; Thomas A. Erickson

    2009-03-31

    U.S. Department of Energy (DOE) Cooperative Agreement DE-FC26-98FT40321 funded through the Office of Fossil Energy and administered at the National Energy Technology Laboratory (NETL) supported the performance of a Jointly Sponsored Research Program (JSRP) at the Energy & Environmental Research Center (EERC) with a minimum 50% nonfederal cost share to assist industry in commercializing and effectively applying highly efficient, nonpolluting energy systems that meet the nation's requirements for clean fuels, chemicals, and electricity in the 21st century. The EERC in partnership with its nonfederal partners jointly performed 131 JSRP projects for which the total DOE cost share was $22,716,634 (38%) and the nonfederal share was $36,776,573 (62%). Summaries of these projects are presented in this report for six program areas: (1) resource characterization and waste management, (2) air quality assessment and control, (3) advanced power systems, (4) advanced fuel forms, (5) value-added coproducts, and (6) advanced materials. The work performed under this agreement addressed DOE goals for reductions in CO{sub 2} emissions through efficiency, capture, and sequestration; near-zero emissions from highly efficient coal-fired power plants; environmental control capabilities for SO{sub 2}, NO{sub x}, fine respirable particulate (PM{sub 2.5}), and mercury; alternative transportation fuels including liquid synfuels and hydrogen; and synergistic integration of fossil and renewable resources.

  18. Component fragility research program

    International Nuclear Information System (INIS)

    Tsai, N.C.; Mochizuki, G.L.; Holman, G.S.

    1989-11-01

    To demonstrate how ''high-level'' qualification test data can be used to estimate the ultimate seismic capacity of nuclear power plant equipment, we assessed in detail various electrical components tested by the Pacific Gas ampersand Electric Company for its Diablo Canyon plant. As part of our Phase I Component Fragility Research Program, we evaluated seismic fragility for five Diablo Canyon components: medium-voltage (4kV) switchgear; safeguard relay board; emergency light battery pack; potential transformer; and station battery and racks. This report discusses our Phase II fragility evaluation of a single Westinghouse Type W motor control center column, a fan cooler motor controller, and three local starters at the Diablo Canyon nuclear power plant. These components were seismically qualified by means of biaxial random motion tests on a shaker table, and the test response spectra formed the basis for the estimate of the seismic capacity of the components. The seismic capacity of each component is referenced to the zero period acceleration (ZPA) and, in our Phase II study only, to the average spectral acceleration (ASA) of the motion at its base. For the motor control center, the seismic capacity was compared to the capacity of a Westinghouse Five-Star MCC subjected to actual fragility tests by LLNL during the Phase I Component Fragility Research Program, and to generic capacities developed by the Brookhaven National Laboratory for motor control center. Except for the medium-voltage switchgear, all of the components considered in both our Phase I and Phase II evaluations were qualified in their standard commercial configurations or with only relatively minor modifications such as top bracing of cabinets. 8 refs., 67 figs., 7 tabs

  19. Genetically programmed chiral organoborane synthesis

    Science.gov (United States)

    Kan, S. B. Jennifer; Huang, Xiongyi; Gumulya, Yosephine; Chen, Kai; Arnold, Frances H.

    2017-12-01

    Recent advances in enzyme engineering and design have expanded nature’s catalytic repertoire to functions that are new to biology. However, only a subset of these engineered enzymes can function in living systems. Finding enzymatic pathways that form chemical bonds that are not found in biology is particularly difficult in the cellular environment, as this depends on the discovery not only of new enzyme activities, but also of reagents that are both sufficiently reactive for the desired transformation and stable in vivo. Here we report the discovery, evolution and generalization of a fully genetically encoded platform for producing chiral organoboranes in bacteria. Escherichia coli cells harbouring wild-type cytochrome c from Rhodothermus marinus (Rma cyt c) were found to form carbon-boron bonds in the presence of borane-Lewis base complexes, through carbene insertion into boron-hydrogen bonds. Directed evolution of Rma cyt c in the bacterial catalyst provided access to 16 novel chiral organoboranes. The catalyst is suitable for gram-scale biosynthesis, providing up to 15,300 turnovers, a turnover frequency of 6,100 h-1, a 99:1 enantiomeric ratio and 100% chemoselectivity. The enantiopreference of the biocatalyst could also be tuned to provide either enantiomer of the organoborane products. Evolved in the context of whole-cell catalysts, the proteins were more active in the whole-cell system than in purified forms. This study establishes a DNA-encoded and readily engineered bacterial platform for borylation; engineering can be accomplished at a pace that rivals the development of chemical synthetic methods, with the ability to achieve turnovers that are two orders of magnitude (over 400-fold) greater than those of known chiral catalysts for the same class of transformation. This tunable method for manipulating boron in cells could expand the scope of boron chemistry in living systems.

  20. Using genetic programming to find Lyapunov functions

    NARCIS (Netherlands)

    Soute, I.A.C.; Molengraft, van de M.J.G.; Angelis, G.Z.; Ryan, C; Spector, L.

    2001-01-01

    In this paper Genetic Programming is used to find Lyapunov functions for (non)linear dif ferential equations of autonomous systems. As Lyapunov functions can be difficult to find, we use OP to make the decisions concerning the form of the Lyapunov function. As an e5cample two systems are taken to

  1. Consensus statement on genetic research in dementia

    DEFF Research Database (Denmark)

    Rikkert, M.G. Olde; der, V van; Burns, A.

    2008-01-01

    In this article, the authors describe how the European Dementia Consensus Network developed a consensus on research ethics in dementia, taking into account the questions posed by the era of genetic research and its new research methods. The consensus process started with a Delphi procedure...... to analyze relevant stakeholders' positions by describing their statements on the possibilities and limitations of research into genetic determinants of Alzheimer disease and to describe and analyze the moral desirability of genetic research on Alzheimer disease. The conclusions drawn from the Delphi...... procedure fuelled the development of the consensus statement, which is presented in this paper. The consensus statement aims to stimulate ethically acceptable research in the field of dementia and the protection of vulnerable elderly patients with dementia from application of inadequate research methods...

  2. Genetic programming applied to RFI mitigation in radio astronomy

    Science.gov (United States)

    Staats, K.

    2016-12-01

    Genetic Programming is a type of machine learning that employs a stochastic search of a solutions space, genetic operators, a fitness function, and multiple generations of evolved programs to resolve a user-defined task, such as the classification of data. At the time of this research, the application of machine learning to radio astronomy was relatively new, with a limited number of publications on the subject. Genetic Programming had never been applied, and as such, was a novel approach to this challenging arena. Foundational to this body of research, the application Karoo GP was developed in the programming language Python following the fundamentals of tree-based Genetic Programming described in "A Field Guide to Genetic Programming" by Poli, et al. Karoo GP was tasked with the classification of data points as signal or radio frequency interference (RFI) generated by instruments and machinery which makes challenging astronomers' ability to discern the desired targets. The training data was derived from the output of an observation run of the KAT-7 radio telescope array built by the South African Square Kilometre Array (SKA-SA). Karoo GP, kNN, and SVM were comparatively employed, the outcome of which provided noteworthy correlations between input parameters, the complexity of the evolved hypotheses, and performance of raw data versus engineered features. This dissertation includes description of novel approaches to GP, such as upper and lower limits to the size of syntax trees, an auto-scaling multiclass classifier, and a Numpy array element manager. In addition to the research conducted at the SKA-SA, it is described how Karoo GP was applied to fine-tuning parameters of a weather prediction model at the South African Astronomical Observatory (SAAO), to glitch classification at the Laser Interferometer Gravitational-wave Observatory (LIGO), and to astro-particle physics at The Ohio State University.

  3. Research on uranium resource models. Part IV. Logic: a computer graphics program to construct integrated logic circuits for genetic-geologic models. Progress report

    International Nuclear Information System (INIS)

    Scott, W.A.; Turner, R.M.; McCammon, R.B.

    1981-01-01

    Integrated logic circuits were described as a means of formally representing genetic-geologic models for estimating undiscovered uranium resources. The logic circuits are logical combinations of selected geologic characteristics judged to be associated with particular types of uranium deposits. Each combination takes on a value which corresponds to the combined presence, absence, or don't know states of the selected characteristic within a specified geographic cell. Within each cell, the output of the logic circuit is taken as a measure of the favorability of occurrence of an undiscovered deposit of the type being considered. In this way, geological, geochemical, and geophysical data are incorporated explicitly into potential uranium resource estimates. The present report describes how integrated logic circuits are constructed by use of a computer graphics program. A user's guide is also included

  4. Understanding of research, genetics and genetic research in a rapid ethical assessment in north west Cameroon.

    Science.gov (United States)

    Kengne-Ouafo, Jonas A; Millard, James D; Nji, Theobald M; Tantoh, William F; Nyoh, Doris N; Tendongfor, Nicholas; Enyong, Peter A; Newport, Melanie J; Davey, Gail; Wanji, Samuel

    2016-05-01

    There is limited assessment of whether research participants in low-income settings are afforded a full understanding of the meaning of medical research. There may also be particular issues with the understanding of genetic research. We used a rapid ethical assessment methodology to explore perceptions surrounding the meaning of research, genetics and genetic research in north west Cameroon. Eleven focus group discussions (including 107 adults) and 72 in-depth interviews were conducted with various stakeholders in two health districts in north west Cameroon between February and April 2012. Most participants appreciated the role of research in generating knowledge and identified a difference between research and healthcare but gave varied explanations as to this difference. Most participants' understanding of genetics was limited to concepts of hereditary, with potential benefits limited to the level of the individual or family. Explanations based on supernatural beliefs were identified as a special issue but participants tended not to identify any other special risks with genetic research. We demonstrated a variable level of understanding of research, genetics and genetic research, with implications for those carrying out genetic research in this and other low resource settings. Our study highlights the utility of rapid ethical assessment prior to complex or sensitive research. © The Author 2015. Published by Oxford University Press on behalf of Royal Society of Tropical Medicine and Hygiene.

  5. Genetic Programming for Medicinal Plant Family Identification System

    Directory of Open Access Journals (Sweden)

    Indra Laksmana

    2014-11-01

    Full Text Available Information about medicinal plants that is available in text documents is generally quite easy to access, however, one needs some efforts to use it. This research was aimed at utilizing crucial information taken from a text document to identify the family of several species of medicinal plants using a heuristic approach, i.e. genetic programming. Each of the species has its unique features. The genetic program puts the characteristics or special features of each family into a tree form. There are a number of processes involved in the investigated method, i.e. data acquisition, booleanization, grouping of training and test data, evaluation, and analysis. The genetic program uses a training process to select the best individual, initializes a generate-rule process to create several individuals and then executes a fitness evaluation. The next procedure is a genetic operation process, which consists of tournament selection to choose the best individual based on a fitness value, the crossover operation and the mutation operation. These operations have the purpose of complementing the individual. The best individual acquired is the expected solution, which is a rule for classifying medicinal plants. This process produced three rules, one for each plant family, displaying a feature structure that distinguishes each of the families from each other. The genetic program then used these rules to identify the medicinal plants, achieving an average accuracy of 86.47%.

  6. Genetic Programming for Automatic Hydrological Modelling

    Science.gov (United States)

    Chadalawada, Jayashree; Babovic, Vladan

    2017-04-01

    One of the recent challenges for the hydrologic research community is the need for the development of coupled systems that involves the integration of hydrologic, atmospheric and socio-economic relationships. This poses a requirement for novel modelling frameworks that can accurately represent complex systems, given, the limited understanding of underlying processes, increasing volume of data and high levels of uncertainity. Each of the existing hydrological models vary in terms of conceptualization and process representation and is the best suited to capture the environmental dynamics of a particular hydrological system. Data driven approaches can be used in the integration of alternative process hypotheses in order to achieve a unified theory at catchment scale. The key steps in the implementation of integrated modelling framework that is influenced by prior understanding and data, include, choice of the technique for the induction of knowledge from data, identification of alternative structural hypotheses, definition of rules, constraints for meaningful, intelligent combination of model component hypotheses and definition of evaluation metrics. This study aims at defining a Genetic Programming based modelling framework that test different conceptual model constructs based on wide range of objective functions and evolves accurate and parsimonious models that capture dominant hydrological processes at catchment scale. In this paper, GP initializes the evolutionary process using the modelling decisions inspired from the Superflex framework [Fenicia et al., 2011] and automatically combines them into model structures that are scrutinized against observed data using statistical, hydrological and flow duration curve based performance metrics. The collaboration between data driven and physical, conceptual modelling paradigms improves the ability to model and manage hydrologic systems. Fenicia, F., D. Kavetski, and H. H. Savenije (2011), Elements of a flexible approach

  7. Legal implications of genetics and crime research.

    Science.gov (United States)

    Denno, D W

    1996-01-01

    Two controversial topics dominate discussions of the legal implications of genetics and crime research; (1) the viability and politics of such research, which has sparked fervent debate in the USA; and (2) the current status of new or atypical criminal law defences, which would include a genetic-defect defence to criminal behaviour. This chapter begins by examining the scientifically discredited XYY chromosome syndrome defence, the major genetic-defect defence that defendants have attempted, albeit unsuccessfully. It then focuses on attorneys' efforts to test for evidence of genetic abnormality in the recent and highly publicized case involving convicted murderer Stephen Mobley, whose family history reveals four generations of violent, aggressive and behaviourally disordered men and women. Mobley is currently appealing his death sentence before the Georgia Supreme Court on the basis that the trial court denied his request both to have genetic testing performed and to have such testing allowed as evidence into court. This chapter concludes by emphasizing that the question is not whether genetic evidence will ever be admitted into court, but when and under what kinds of circumstances. No doubt, genetic evidence, and comparable kinds of biological evidence, will have a major impact on juries when such evidence is more fully accepted by the legal and scientific communities.

  8. Considering genetic characteristics in German Holstein breeding programs.

    Science.gov (United States)

    Segelke, D; Täubert, H; Reinhardt, F; Thaller, G

    2016-01-01

    Recently, several research groups have demonstrated that several haplotypes may cause embryonic loss in the homozygous state. Up to now, carriers of genetic disorders were often excluded from mating, resulting in a decrease of genetic gain and a reduced number of sires available for the breeding program. Ongoing research is very likely to identify additional genetic defects causing embryonic loss and calf mortality by genotyping a large proportion of the female cattle population and sequencing key ancestors. Hence, a clear demand is present to develop a method combining selection against recessive defects (e.g., Holstein haplotypes HH1-HH5) with selection for economically beneficial traits (e.g., polled) for mating decisions. Our proposed method is a genetic index that accounts for the allele frequencies in the population and the economic value of the genetic characteristic without excluding carriers from breeding schemes. Fertility phenotypes from routine genetic evaluations were used to determine the economic value per embryo lost. Previous research has shown that embryo loss caused by HH1 and HH2 occurs later than the loss for HH3, HH4, and HH5. Therefore, an economic value of € 97 was used against HH1 and HH2 and € 70 against HH3, HH4, and HH5. For polled, € 7 per polled calf was considered. Minor allele frequencies of the defects ranged between 0.8 and 3.3%. The polled allele has a frequency of 4.1% in the German Holstein population. A genomic breeding program was simulated to study the effect of changing the selection criteria from assortative mating based on breeding values to selecting the females using the genetic index. Selection for a genetic index on the female path is a useful method to control the allele frequencies by reducing undesirable alleles and simultaneously increasing economical beneficial characteristics maintaining most of the genetic gain in production and functional traits. Additionally, we applied the genetic index to real data and

  9. Research Programs & Initiatives

    Science.gov (United States)

    CGH develops international initiatives and collaborates with other NCI divisions, NCI-designated Cancer Centers, and other countries to support cancer control planning, encourage capacity building, and support cancer research and research networks.

  10. 7. Framework Research Program

    International Nuclear Information System (INIS)

    Donghi, C.; Pieri, Alberto; Manzini, G.

    2006-01-01

    The UE it means to face the problem of the deficiency if investments in the RS field. In particular politics of research are turned to pursue three main goals: the strengthening of the scientific excellence in Europe; the increase of total investments for research; the realization of European space of research [it

  11. Equipment qualification research program: program plan

    International Nuclear Information System (INIS)

    Dong, R.G.; Smith, P.D.

    1982-01-01

    The Lawrence Livermore National Laboratory (LLNL) under the sponsorship of the US Nuclear Regulatory Commission (NRC) has developed this program plan for research in equipment qualification (EQA). In this report the research program which will be executed in accordance with this plan will be referred to as the Equipment Qualification Research Program (EQRP). Covered are electrical and mechanical equipment under the conditions described in the OBJECTIVE section of this report. The EQRP has two phases; Phase I is primarily to produce early results and to develop information for Phase II. Phase I will last 18 months and consists of six projects. The first project is program management. The second project is responsible for in-depth evaluation and review of EQ issues and EQ processes. The third project is responsible for detailed planning to initiate Phase II. The remaining three projects address specific equipment; i.e., valves, electrical equipment, and a pump

  12. [Advances in genetic research of cerebral palsy].

    Science.gov (United States)

    Wang, Fang-Fang; Luo, Rong; Qu, Yi; Mu, De-Zhi

    2017-09-01

    Cerebral palsy is a group of syndromes caused by non-progressive brain injury in the fetus or infant and can cause disabilities in childhood. Etiology of cerebral palsy has always been a hot topic for clinical scientists. More and more studies have shown that genetic factors are closely associated with the development of cerebral palsy. With the development and application of various molecular and biological techniques such as chromosome microarray analysis, genome-wide association study, and whole exome sequencing, new achievements have been made in the genetic research of cerebral palsy. Chromosome abnormalities, copy number variations, susceptibility genes, and single gene mutation associated with the development of cerebral palsy have been identified, which provides new opportunities for the research on the pathogenesis of cerebral palsy. This article reviews the advances in the genetic research on cerebral palsy in recent years.

  13. Epidemiologic research program: Selected bibliography

    International Nuclear Information System (INIS)

    1993-05-01

    This bibliography is a current listing of scientific reports from epidemiologic and related activities sponsored by the Department of Energy. The Office of Epidemiology and Health Surveillance now is the departmental focal point for these activities and any others relating to the study of human health effects. The Office's mission is evolving to encompass the new role of the Department in environmental restoration, weapons dismantlement and nuclear material storage, and development of new energy technologies. Publications in these areas will be included in future editions of the bibliography. The present edition brings the listing up to date, and should facilitate access to specific reports. The program has been divided into several general areas of activity: the Radiation Effects Research Foundation, which supports studies of survivors of the atomic weapons in Hiroshima and Nagasaki; mortality and morbidity studies of DOE workers; studies on internally deposited alpha emitters; medical/histologic studies; studies on the genetic aspects of radiation damage; community health surveillance studies; and the development of computational techniques and of databases to make the results as widely useful as possible

  14. Ecological Research Division, Marine Research Program

    Energy Technology Data Exchange (ETDEWEB)

    1980-05-01

    This report presents program summaries of the various projects sponsored during 1979 by the Marine Research Program of the Ecological Research Division. Program areas include the effects of petroleum hydrocarbons on the marine environment; a study of the baseline ecology of a proposed OTEC site near Puerto Rico; the environmental impact of offshore geothermal energy development; the movement of radionuclides through the marine environment; the environmental aspects of power plant cooling systems; and studies of the physical and biological oceangraphy of the continental shelves bordering the United States.

  15. Ecological Research Division, Marine Research Program

    International Nuclear Information System (INIS)

    1980-05-01

    This report presents program summaries of the various projects sponsored during 1979 by the Marine Research Program of the Ecological Research Division. Program areas include the effects of petroleum hydrocarbons on the marine environment; a study of the baseline ecology of a proposed OTEC site near Puerto Rico; the environmental impact of offshore geothermal energy development; the movement of radionuclides through the marine environment; the environmental aspects of power plant cooling systems; and studies of the physical and biological oceangraphy of the continental shelves bordering the United States

  16. Nuclear wastes: research programs

    International Nuclear Information System (INIS)

    Anon.

    2003-01-01

    The management of long-living and high level radioactive wastes in France belongs to the framework of the December 30, 1991 law which defines three ways of research: the separation and transmutation of radionuclides, their reversible storage or disposal in deep geologic formations, and their processing and surface storage during long duration. Research works are done in partnership between public research and industrial organizations in many French and foreign laboratories. Twelve years after its enforcement, the impact of this law has overstepped the simple research framework and has led to a deep reflection of the society about the use of nuclear energy. This short paper presents the main results obtained so far in the three research ways, the general energy policy of the French government, the industrial progresses made in the framework of the 1991 law and the international context of the management of nuclear wastes. (J.S.)

  17. NCI: DCTD: Biometric Research Program

    Science.gov (United States)

    The Biometric Research Program (BRP) is the statistical and biomathematical component of the Division of Cancer Treatment, Diagnosis and Centers (DCTDC). Its members provide statistical leadership for the national and international research programs of the division in developmental therapeutics, developmental diagnostics, diagnostic imaging and clinical trials.

  18. Privacy and policy for genetic research.

    Science.gov (United States)

    DeCew, Judith Wagner

    2004-01-01

    I begin with a discussion of the value of privacy and what we lose without it. I then turn to the difficulties of preserving privacy for genetic information and other medical records in the face of advanced information technology. I suggest three alternative public policy approaches to the problem of protecting individual privacy and also preserving databases for genetic research: (1) governmental guidelines and centralized databases, (2) corporate self-regulation, and (3) my hybrid approach. None of these are unproblematic; I discuss strengths and drawbacks of each, emphasizing the importance of protecting the privacy of sensitive medical and genetic information as well as letting information technology flourish to aid patient care, public health and scientific research.

  19. Human Research Program

    Data.gov (United States)

    National Aeronautics and Space Administration — Strategically, the HRP conducts research and technology development that: 1) enables the development or modification of Agency-level human health and performance...

  20. 76 FR 72424 - Submission for OMB Review; Comment Request Information Program on the Genetic Testing Registry

    Science.gov (United States)

    2011-11-23

    ... particular tests; and (3) facilitating genetic and genomic data-sharing for research and new scientific...; Comment Request Information Program on the Genetic Testing Registry AGENCY: National Institutes of Health... currently valid OMB control number. Proposed Collection: Title: The Genetic Testing Registry; Type of...

  1. Radon Research Program, FY-1990

    International Nuclear Information System (INIS)

    1991-03-01

    The Department of Energy (DOE) Office of Health and Environmental Research (OHER) has established a Radon Research Program with the primary objectives of acquiring knowledge necessary to improve estimates of health risks associated with radon exposure and also to improve radon control. Through the Radon Research Program, OHER supports and coordinates the research activities of investigators at facilities all across the nation. From this research, significant advances are being made in our understanding of the health effects of radon. OHER publishes this annual report to provide information to interested researchers and the public about its research activities. This edition of the report summarizes the activities of program researchers during FY90. Chapter 2 of this report describes how risks associated with radon exposure are estimated, what assumptions are made in estimating radon risks for the general public, and how the uncertainties in these assumptions affect the risk estimates. Chapter 3 examines how OHER, through the Radon Research Program, is working to gather information for reducing the uncertainties and improving the risk estimates. Chapter 4 highlights some of the major findings of investigators participating in the Radon Research Program in the past year. And, finally, Chapter 5 discusses the direction in which the program is headed in the future. 20 figs

  2. Tansmutation Research program

    Energy Technology Data Exchange (ETDEWEB)

    Seidler, Paul

    2011-07-31

    Six years of research was conducted for the United States Department of Energy, Office of Nuclear Energy between the years of 2006 through 2011 at the University of Nevada, Las Vegas (UNLV). The results of this research are detailed in the narratives for tasks 1-45. The work performed spanned the range of experimental and modeling efforts. Radiochemistry (separations, waste separation, nuclear fuel, remote sensing, and waste forms) , material fabrication, material characterization, corrosion studies, nuclear criticality, sensors, and modeling comprise the major topics of study during these six years.

  3. Geometric Semantic Genetic Programming Algorithm and Slump Prediction

    OpenAIRE

    Xu, Juncai; Shen, Zhenzhong; Ren, Qingwen; Xie, Xin; Yang, Zhengyu

    2017-01-01

    Research on the performance of recycled concrete as building material in the current world is an important subject. Given the complex composition of recycled concrete, conventional methods for forecasting slump scarcely obtain satisfactory results. Based on theory of nonlinear prediction method, we propose a recycled concrete slump prediction model based on geometric semantic genetic programming (GSGP) and combined it with recycled concrete features. Tests show that the model can accurately p...

  4. Research on Automatic Programming

    Science.gov (United States)

    1975-12-31

    Sequential processes, deadlocks, and semaphore primitives , Ph.D. Thesis, Harvard University, November 1974; Center for Research in Computing...verified. 13 Code generated to effect the synchronization makes use of the ECL control extension facility (Prenner’s CI, see [Prenner]). The... semaphore operations [Dijkstra] is being developed. Initial results for this code generator are very encouraging; in many cases generated code is

  5. Biological Defense Research Program

    Science.gov (United States)

    1989-04-01

    difference between life and death. Some recent examples are: BDRP developed VEE vaccine used in Central America, Mexico , and Texas (1969- 1971.) and Rift...Complex, is adn area owned by the Bureau of Land Management, which is available for grazina, and with specific permission, for use by DPG. 2.3...2.01 A Large European Laboratory, 1944-1950 50.00 Tuberculosis Laboratory 4 Technicians, Canada, 1947-1954 19.00 Research Institutes, 1930-1950 4.10

  6. Military Vision Research Program

    Science.gov (United States)

    2011-07-01

    Bietti Eye Foundation, IRCCS Rome, Italy . Word count: 2879 Corresponding author: Reza Dana, M.D., M.P.H., M.Sc. Schepens Eye Research...Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA 02114 3 Bietti Eye Foundation, IRCCS Rome, Italy . Word count: 2879...with differentiated properties. Exp Eye Res. 62, 155-169. 18. Marneros A.G., Fan J., Yokoyama Y., Gerber H.P., Ferrara N., Crouch R.K., Olsen B.R

  7. A NEW MUTATION OPERATOR IN GENETIC PROGRAMMING

    Directory of Open Access Journals (Sweden)

    Anuradha Purohit

    2013-01-01

    Full Text Available This paper proposes a new type of mutation operator, FEDS (Fitness, Elitism, Depth, and Size mutation in genetic programming. The concept behind the new mutation operator is inspired from already introduced FEDS crossover operator to handle the problem of code bloating. FEDS mutation operates by using local elitism replacement in combination with depth limit and size of the trees to reduce bloat with a subsequent improvement in the performance of trees (program structures. We have designed a multiclass classifier for some benchmark datasets to test the performance of proposed mutation. The results show that when the initial run uses FEDS crossover and the concluding run uses FEDS mutation, then not only is the final result significantly improved but there is reduction in bloat also.

  8. Laboratory Directed Research ampersand Development Program

    International Nuclear Information System (INIS)

    Ogeka, G.J.; Romano, A.J.

    1993-12-01

    At Brookhaven National Laboratory the Laboratory Directed Research and Development (LDRD) Program is a discretionary research and development tool critical in maintaining the scientific excellence and vitality of the laboratory. It is also a means to stimulate the scientific community, fostering new science and technology ideas, which is the major factor in achieving and maintaining staff excellence, and a means to address national needs, within the overall mission of the Department of Energy and Brookhaven National Laboratory. This report summarizes research which was funded by this program during fiscal year 1993. The research fell in a number of broad technical and scientific categories: new directions for energy technologies; global change; radiation therapies and imaging; genetic studies; new directions for the development and utilization of BNL facilities; miscellaneous projects. Two million dollars in funding supported 28 projects which were spread throughout all BNL scientific departments

  9. Radon Research Program, FY 1991

    International Nuclear Information System (INIS)

    1992-03-01

    The scientific information being sought in this program encompasses research designed to determine radon availability and transport outdoors, modeling transport into and within buildings, physics and chemistry of radon and radon progeny, dose response relationships, lung cancer risk, and mechanisms of radon carcinogenesis. The main goal of the DOE/OHER Radon Research Program is to develop information to reduce these uncertainties and thereby provide an improved health risk estimate of exposure to radon and its progeny as well as to provide information useful in radon control strategies. Results generated under the Program were highlighted in a National Research Council report on radon dosimetry. The study concluded that the risk of radon exposure is 30% less in homes than in mines. This program summary of book describes the OHER FY-1991 Radon Research Program. It is the fifth in an annual series of program books designed to provide scientific and research information to the public and to other government agencies on the DOE Radon Research Program

  10. Fusion research program in Korea

    International Nuclear Information System (INIS)

    Hwang, Y.S.

    1996-01-01

    Fusion research in Korea is still premature, but it is a fast growing program. Groups in several universities and research institutes were working either in small experiments or in theoretical areas. Recently, couple of institutes who have small fusion-related experiments, proposed medium-size tokamak programs to jump into fusion research at the level of international recognition. Last year, Korean government finally approved to construct 'Superconducting Tokamak' as a national fusion program, and industries such as Korea Electric Power Corp. (KEPCO) and Samsung joined to support this program. Korea Basic Science Institute (KBSI) has organized national project teams including universities, research institutes and companies. National project teams are performing design works since this March. (author)

  11. International Research and Studies Program

    Science.gov (United States)

    Office of Postsecondary Education, US Department of Education, 2012

    2012-01-01

    The International Research and Studies Program supports surveys, studies, and instructional materials development to improve and strengthen instruction in modern foreign languages, area studies, and other international fields. The purpose of the program is to improve and strengthen instruction in modern foreign languages, area studies and other…

  12. Gordon Research Conference on Genetic Toxicology

    Energy Technology Data Exchange (ETDEWEB)

    Project Director Penelope Jeggo

    2003-02-15

    Genetic toxicology represents a study of the genetic damage that a cell can incur, the agents that induce such damage, the damage response mechanisms available to cells and organisms, and the potential consequences of such damage. Genotoxic agents are abundant in the environment and are also induced endogenously. The consequences of such damage can include carcinogenesis and teratogenesis. An understanding of genetic toxicology is essential to carry out risk evaluations of the impact of genotoxic agents and to assess how individual genetic differences influence the response to genotoxic damage. In recent years, the importance of maintaining genomic stability has become increasingly recognized, in part by the realization that failure of the damage response mechanisms underlies many, if not all, cancer incidence. The importance of these mechanisms is also underscored by their remarkable conservation between species, allowing the study of simple organisms to provide significant input into our understanding of the underlying mechanisms. It has also become clear that the damage response mechanisms interface closely with other aspects of cellular metabolism including replication, transcription and cell cycle regulation. Moreover, defects in many of these mechanisms, as observed for example in ataxia telangiectasia patients, confer disorders with associated developmental abnormalities demonstrating their essential roles during growth and development. In short, while a decade ago, a study of the impact of DNA damage was seen as a compartmentalized area of cellular research, it is now appreciated to lie at the centre of an array of cellular responses of crucial importance to human health. Consequently, this has become a dynamic and rapidly advancing area of research. The Genetic Toxicology Gordon Research Conference is biannual with an evolving change in the emphasis of the meetings. From evaluating the nature of genotoxic chemicals, which lay at the centre of the early

  13. Can Research on the Genetics of Intelligence Be "Socially Neutral"?

    Science.gov (United States)

    Roberts, Dorothy

    2015-01-01

    The history of research on the genetics of intelligence is fraught with social bias. During the eugenics era, the hereditary theory of intelligence justified policies that encouraged the proliferation of favored races and coercively stemmed procreation by disfavored ones. In the 1970s, Berkeley psychologist Arthur Jensen argued that black students' innate cognitive inferiority limited the efficacy of federal education programs. The 1994 controversial bestseller The Bell Curve, by Richard J. Herrnstein and Charles Murray, rehashed the claim that race and class disparities stem from immutable differences in inherited intelligence, which could not be eliminated through social interventions. Today most scientists studying the genetics of intelligence distance themselves from this history of social bias by arguing that their research need not investigate intellectual differences between social groups. Rather, they argue, examining the heritability of intelligence can be socially neutral and may even help to reduce social inequities. I argue, however, that research on the genetics of intelligence cannot be socially neutral. Even if we divorce the heritability of intelligence from a eugenicist mission, measuring intelligence remains useful only as a gage of individuals' appropriate positions in society. Research into the genetics of intelligence ultimately helps to determine individuals' inherited capacity for particular social positions, even when researchers aim to modify the effects of inheritance. © 2015 The Hastings Center.

  14. Research program on regulatory safety research

    International Nuclear Information System (INIS)

    Mailaender, R.

    2010-02-01

    This paper elaborated for the Swiss Federal Office of Energy (SFOE) presents the synthesis report for 2009 made by the SFOE's program leader on the research program concerning regulatory nuclear safety research, as co-ordinated by the Swiss Nuclear Safety Inspectorate ENSI. Work carried out in various areas is reviewed, including that done on reactor safety, radiation protection and waste disposal as well as human aspects, organisation and safety culture. Work done concerning materials, pressure vessel integrity, transient analysis, the analysis of serious accidents in light-water reactors, fuel and material behaviour, melt cooling and concrete interaction is presented. OECD data bank topics are discussed. Transport and waste disposal research at the Mont Terri rock laboratory is looked at. Requirements placed on the personnel employed in nuclear power stations are examined and national and international co-operation is reviewed

  15. Genetics Research Discovered in a Bestseller | Poster

    Science.gov (United States)

    By Nancy Parrish, Staff Writer One morning in early January, Amar Klar sat down at his computer and found an e-mail with a curious message from a colleague. While reading a bestselling novel, The Marriage Plot by Jeffrey Eugenides, his colleague, a professor at Princeton University, found a description of research on yeast genetics that was surprisingly similar to Klar’s early

  16. Jointly Sponsored Research Program Energy Related Research

    Energy Technology Data Exchange (ETDEWEB)

    Western Research Institute

    2009-03-31

    Cooperative Agreement, DE-FC26-98FT40323, Jointly Sponsored Research (JSR) Program at Western Research Institute (WRI) began in 1998. Over the course of the Program, a total of seventy-seven tasks were proposed utilizing a total of $23,202,579 in USDOE funds. Against this funding, cosponsors committed $26,557,649 in private funds to produce a program valued at $49,760,228. The goal of the Jointly Sponsored Research Program was to develop or assist in the development of innovative technology solutions that will: (1) Increase the production of United States energy resources - coal, natural gas, oil, and renewable energy resources; (2) Enhance the competitiveness of United States energy technologies in international markets and assist in technology transfer; (3) Reduce the nation's dependence on foreign energy supplies and strengthen both the United States and regional economies; and (4) Minimize environmental impacts of energy production and utilization. Under the JSR Program, energy-related tasks emphasized enhanced oil recovery, heavy oil upgrading and characterization, coal beneficiation and upgrading, coal combustion systems development including oxy-combustion, emissions monitoring and abatement, coal gasification technologies including gas clean-up and conditioning, hydrogen and liquid fuels production, coal-bed methane recovery, and the development of technologies for the utilization of renewable energy resources. Environmental-related activities emphasized cleaning contaminated soils and waters, processing of oily wastes, mitigating acid mine drainage, and demonstrating uses for solid waste from clean coal technologies, and other advanced coal-based systems. Technology enhancement activities included resource characterization studies, development of improved methods, monitors and sensors. In general the goals of the tasks proposed were to enhance competitiveness of U.S. technology, increase production of domestic resources, and reduce environmental

  17. Testing the structure of a hydrological model using Genetic Programming

    Science.gov (United States)

    Selle, Benny; Muttil, Nitin

    2011-01-01

    SummaryGenetic Programming is able to systematically explore many alternative model structures of different complexity from available input and response data. We hypothesised that Genetic Programming can be used to test the structure of hydrological models and to identify dominant processes in hydrological systems. To test this, Genetic Programming was used to analyse a data set from a lysimeter experiment in southeastern Australia. The lysimeter experiment was conducted to quantify the deep percolation response under surface irrigated pasture to different soil types, watertable depths and water ponding times during surface irrigation. Using Genetic Programming, a simple model of deep percolation was recurrently evolved in multiple Genetic Programming runs. This simple and interpretable model supported the dominant process contributing to deep percolation represented in a conceptual model that was published earlier. Thus, this study shows that Genetic Programming can be used to evaluate the structure of hydrological models and to gain insight about the dominant processes in hydrological systems.

  18. Rethinking Research for Genetically Modified (GM) Food

    OpenAIRE

    Yin-Ling; Lin

    2012-01-01

    This paper suggests a rethinking of the existing research about Genetically Modified (GM) food. Since the first batch of GM food was commercialised in the UK market, GM food rapidly received and lost media attention in the UK. Disagreement on GM food policy between the US and the EU has also drawn scholarly attention to this issue. Much research has been carried out intending to understand people-s views about GM food and the shaping of these views. This paper was based o...

  19. Program of Research in Aeronautics

    Science.gov (United States)

    1981-01-01

    A prospectus of the educational and research opportunities available at the Joint Institute for Advancement of Flight Sciences, operated at NASA Langley Research Center in conjunction with George Washington University's School of Engineering and Applied Sciences is presented. Requirements of admission to various degree programs are given as well as the course offerings in the areas of acoustics, aeronautics, environmental modelling, materials science, and structures and dynamics. Research facilities for each field of study are described. Presentations and publications (including dissertations and theses) generated by each program are listed as well as faculty members visting scientists and engineers.

  20. Fusion program research materials inventory

    International Nuclear Information System (INIS)

    Roche, T.K.; Wiffen, F.W.; Davis, J.W.; Lechtenberg, T.A.

    1984-01-01

    Oak Ridge National Laboratory maintains a central inventory of research materials to provide a common supply of materials for the Fusion Reactor Materials Program. This will minimize unintended material variations and provide for economy in procurement and for centralized record keeping. Initially this inventory is to focus on materials related to first-wall and structural applications and related research, but various special purpose materials may be added in the future. The use of materials from this inventory for research that is coordinated with or otherwise related technically to the Fusion Reactor Materials Program of DOE is encouraged

  1. NASA's computer science research program

    Science.gov (United States)

    Larsen, R. L.

    1983-01-01

    Following a major assessment of NASA's computing technology needs, a new program of computer science research has been initiated by the Agency. The program includes work in concurrent processing, management of large scale scientific databases, software engineering, reliable computing, and artificial intelligence. The program is driven by applications requirements in computational fluid dynamics, image processing, sensor data management, real-time mission control and autonomous systems. It consists of university research, in-house NASA research, and NASA's Research Institute for Advanced Computer Science (RIACS) and Institute for Computer Applications in Science and Engineering (ICASE). The overall goal is to provide the technical foundation within NASA to exploit advancing computing technology in aerospace applications.

  2. Research program plan: steam generators

    International Nuclear Information System (INIS)

    Muscara, J.; Serpan, C.Z. Jr.

    1985-07-01

    This document presents a plan for research in Steam Generators to be performed by the Materials Engineering Branch, MEBR, Division of Engineering Technology, (EDET), Office of Nuclear Regulatory Research. It is one of four plans describing the ongoing research in the corresponding areas of MEBR activity. In order to answer the questions posed, the Steam Generator Program has been organized with the three elements of non-destructive examination; mechanical integrity testing; and corrosion, cleaning and decontamination

  3. The sheep blowfly genetic control program in Australia

    International Nuclear Information System (INIS)

    Foster, Geoffrey G.

    1989-01-01

    The blowfly Lucilia cuprina is the most important myiasis pet of sheep in Australia. Other species are associated with sheep myiasis, but L. cuprina is probably responsible for initiating more than 90% of infestations. Annual costs of production losses, prevention and treatment have been estimated at $149 millions in 1985. Prevention and treatment encompass both insecticidal applications to sheep and non-chemical management practices. In the absence of effective preventive measures, the sheep industry would be non-viable over much of Australia. Insecticide usage against L. cuprina has been marked by the appearance of widespread resistance to cyclodienes in 1956, the organophosphates in 1965, and carbamates in 1966. Resistance has not yet been reported against the triazine compounds introduced for blowfly control in 1981. The most effective non-chemical control measures are surgical (removal of skin from the breech in certain breeds of sheep, and tail-docking). They protect sheep by reducing favourable oviposition sites (dung and urine-stained wool). The spectre of insecticide resistance and the early success of the sterile insect technique (SIT) against screwworm fly in the U.S.A., led this Division to consider SIT and other autocidal methods in the 1960s. The L. cuprina genetics research program was established in 1966 and subsequently expanded in 1971. More recently, lobbying by animal welfare groups against surgical blowfly control practices, as well as increasing consumer awareness of insecticide residues in animal products, have accelerated the search for alternatives to chemical control. When SIT was first considered for L. cuprina control in 1960, little was known about the population dynamics of L. cuprina. There were insufficient ecological data to evaluate the prospects of alternative strategies such as suppression or containment. The number of flies which would have to be released in a SIT program was unknown, as were the costs. Assuming that the cost of

  4. GRI's Devonian Shales Research Program

    International Nuclear Information System (INIS)

    Guidry, F.K.

    1991-01-01

    This paper presents a summary of the key observations and conclusions from the Gas Research Institute's (GRI's) Comprehensive Study Well (CSW) research program conducted in the Devonian Shales of the Appalachian Basin. Initiated in 1987, the CSW program was a series of highly instrumented study wells drilled in cooperation with industry partners. Seven wells were drilled as part of the program. Extensive data sets were collected and special experiments were run on the CSW's in addition to the operator's normal operations, with the objectives of identifying geologic production controls, refining formation evaluation tools, and improving reservoir description and stimulation practices in the Devonian Shales. This paper highlights the key results from the research conducted in the CSW program in the areas of geologic production controls, formation evaluation, stimulation and reservoir engineering, and field operations. The development of geologic, log analysis, and reservoir models for the Shales from the data gathered and analysis, and reservoir models for the Shales from the data gathered and analyzed during the research is discussed. In addition, on the basis of what was learned in the CSW program, GRI's plans for new research in the Devonian Shales are described

  5. Containment integrity research program plan

    International Nuclear Information System (INIS)

    1987-08-01

    This report presents a plan for research on the question of containment performance in postulated severe accident scenarios. It focuses on the research being performed by the Structural and Seismic Engineering Branch, Division of Engineering, Office of Nuclear Regulatory Research. Summaries of the plans for this work have previously been published in the ''Nuclear Power Plant Severe Accident Research Plan'' (NUREG-0900). This report provides an update to reflect current status. This plan provides a summary of results to date as well as an outline of planned activities and milestones to the contemplated completion of the program in FY 1989

  6. Guidelines on the use of molecular genetics in reintroduction programs

    Science.gov (United States)

    Michael K. Schwartz

    2005-01-01

    The use of molecular genetics can play a key role in reintroduction efforts. Prior to the introduction of any individuals, molecular genetics can be used to identify the most appropriate source population for the reintroduction, ensure that no relic populations exist in the reintroduction area, and guide captive breeding programs. The use of molecular genetics post-...

  7. Parental Virtue and Prenatal Genetic Alteration Research.

    Science.gov (United States)

    Tonkens, Ryan

    2015-12-01

    Although the philosophical literature on the ethics of human prenatal genetic alteration (PGA) purports to inform us about how to act, it rarely explicitly recognizes the perspective of those who will be making the PGA decision in practice. Here I approach the ethics of PGA from a distinctly virtue-based perspective, taking seriously what it means to be a good parent making this decision for one's child. From this perspective, I generate a sound verdict on the moral standing of human PGA (research): given the current state of the art, good parents have compelling reason not to consent to PGA (research) for their child, especially as part of the first wave(s) of PGA research participants and especially for non-medically oriented purposes. This is because doing otherwise is inconsistent with a plausible and defensible understanding of virtuous parenting and parental virtues, founded on a genuine concern for promoting the overall flourishing of the eventual child. In essence, given the current and foreseeable state of the art, parents who allow prenatal genetic alteration of their children are less-than-virtuous parents to those children, even in cases where they have a right to do so and even if PGA turns out to be beneficial to the eventual child.

  8. The Australian synchrotron research program

    International Nuclear Information System (INIS)

    Garrett, R.F.

    1998-01-01

    Full text: The Australian Synchrotron Research Program (ASRP) was established in 1996 under a 5 year grant from the Australian Government, and is managed by ANSTO on behalf of a consortium of Australian universities and research organisations. It has taken over the operation of the Australian National Beamline Facility (ANBF) at the Photon Factory, and has joined two CATS at the Advanced Photon Source: the Synchrotron Radiation Instrumentation CAT (SRI-CAT) and the Consortium for Advanced Radiation Sources (CARS). The ASRP thus manages a comprehensive range of synchrotron radiation research facilities for Australian science. The ANBF is a general purpose hard X-ray beamline which has been in operation at the Photon Factory since 1993. It currently caters for about 35 Australian research teams per year. The facilities available at the ANBF will be presented and the research program will be summarised. The ASRP facilities at the APS comprise the 5 sectors operated by SRI-CAT, BioCARS and ChemMatCARS. A brief description will be given of the ASRP research programs at the APS, which will considerably broaden the scope of Australian synchrotron science

  9. Nebraska Prostate Cancer Research Program

    Science.gov (United States)

    2015-10-01

    STUDENT ENGAGEMENT Welcome 2 UNMC 3 Omaha 4 Arrival 5-6 Living 7 Events 8...Graduates 9-11 Channing Bunch, M.B.A Director of Recruitment and Student Engagement channing.bunch...Program, Eppley Institute, Office of Research and Development, and Recruitment and Student Engagement Responses to Nebraska Prostate

  10. Optimiturve research program in 1991

    International Nuclear Information System (INIS)

    Leinonen, A.

    1992-01-01

    The target of the program is to develop a peat production method, based on solar energy, by which it is possible to double the present annual hectare yield. It has been estimated that if the target of the program can be fulfilled it is possible to decrease the production costs by about 20 %. The target has been strived by intensification of utilization of solar radiation, by improving the collection rate of dry peat, by decreasing the rain effects on production, by lengthening the production season and by decreasing the storage losses. Three new peat production methods have so far been developed in the Optimiturve research program, by which it is possible to obtain the targets of the program. These methods are the new sod peat production method, the ridge drying method and the Multi method

  11. Amount of Genetics Education is Low Among Didactic Programs in Dietetics.

    Science.gov (United States)

    Beretich, Kaitlan; Pope, Janet; Erickson, Dawn; Kennedy, Angela

    2017-01-01

    Nutritional genomics is a growing area of research. Research has shown registered dietitian nutritionists (RDNs) have limited knowledge of genetics. Limited research is available regarding how didactic programs in dietetics (DPDs) meet the genetics knowledge requirement of the Accreditation Council for Education in Nutrition and Dietetics (ACEND®). The purpose of this study was to determine the extent to which the study of nutritional genomics is incorporated into undergraduate DPDs in response to the Academy of Nutrition and Dietetics position statement on nutritional genomics. The sample included 62 DPD directors in the U.S. Most programs (63.9%) reported the ACEND genetics knowledge requirement was being met by integrating genetic information into the current curriculum. However, 88.7% of programs reported devoting only 1-10 clock hours to genetics education. While 60.3% of directors surveyed reported they were confident in their program's ability to teach information related to genetics, only 6 directors reported having specialized training in genetics. The overall amount of clock hours devoted to genetics education is low. DPD directors, faculty, and instructors are not adequately trained to provide this education to students enrolled in DPDs. Therefore, the primary recommendation of this study is the development of a standardized curriculum for genetics education in DPDs.

  12. Subsurface transport program: Research summary

    International Nuclear Information System (INIS)

    1987-01-01

    DOE's research program in subsurface transport is designed to provide a base of fundamental scientific information so that the geochemical, hydrological, and biological mechanisms that contribute to the transport and long term fate of energy related contaminants in subsurface ecosystems can be understood. Understanding the physical and chemical mechanisms that control the transport of single and co-contaminants is the underlying concern of the program. Particular attention is given to interdisciplinary research and to geosphere-biosphere interactions. The scientific results of the program will contribute to resolving Departmental questions related to the disposal of energy-producing and defense wastes. The background papers prepared in support of this document contain additional information on the relevance of the research in the long term to energy-producing technologies. Detailed scientific plans and other research documents are available for high priority research areas, for example, in subsurface transport of organic chemicals and mixtures and in the microbiology of deep aquifers. 5 figs., 1 tab

  13. Testing the Structure of Hydrological Models using Genetic Programming

    Science.gov (United States)

    Selle, B.; Muttil, N.

    2009-04-01

    Genetic Programming is able to systematically explore many alternative model structures of different complexity from available input and response data. We hypothesised that genetic programming can be used to test the structure hydrological models and to identify dominant processes in hydrological systems. To test this, genetic programming was used to analyse a data set from a lysimeter experiment in southeastern Australia. The lysimeter experiment was conducted to quantify the deep percolation response under surface irrigated pasture to different soil types, water table depths and water ponding times during surface irrigation. Using genetic programming, a simple model of deep percolation was consistently evolved in multiple model runs. This simple and interpretable model confirmed the dominant process contributing to deep percolation represented in a conceptual model that was published earlier. Thus, this study shows that genetic programming can be used to evaluate the structure of hydrological models and to gain insight about the dominant processes in hydrological systems.

  14. Clean Coal Program Research Activities

    Energy Technology Data Exchange (ETDEWEB)

    Larry Baxter; Eric Eddings; Thomas Fletcher; Kerry Kelly; JoAnn Lighty; Ronald Pugmire; Adel Sarofim; Geoffrey Silcox; Phillip Smith; Jeremy Thornock; Jost Wendt; Kevin Whitty

    2009-03-31

    Although remarkable progress has been made in developing technologies for the clean and efficient utilization of coal, the biggest challenge in the utilization of coal is still the protection of the environment. Specifically, electric utilities face increasingly stringent restriction on the emissions of NO{sub x} and SO{sub x}, new mercury emission standards, and mounting pressure for the mitigation of CO{sub 2} emissions, an environmental challenge that is greater than any they have previously faced. The Utah Clean Coal Program addressed issues related to innovations for existing power plants including retrofit technologies for carbon capture and sequestration (CCS) or green field plants with CCS. The Program focused on the following areas: simulation, mercury control, oxycoal combustion, gasification, sequestration, chemical looping combustion, materials investigations and student research experiences. The goal of this program was to begin to integrate the experimental and simulation activities and to partner with NETL researchers to integrate the Program's results with those at NETL, using simulation as the vehicle for integration and innovation. The investigators also committed to training students in coal utilization technology tuned to the environmental constraints that we face in the future; to this end the Program supported approximately 12 graduate students toward the completion of their graduate degree in addition to numerous undergraduate students. With the increased importance of coal for energy independence, training of graduate and undergraduate students in the development of new technologies is critical.

  15. Developing robotic behavior using a genetic programming model

    International Nuclear Information System (INIS)

    Pryor, R.J.

    1998-01-01

    This report describes the methodology for using a genetic programming model to develop tracking behaviors for autonomous, microscale robotic vehicles. The use of such vehicles for surveillance and detection operations has become increasingly important in defense and humanitarian applications. Through an evolutionary process similar to that found in nature, the genetic programming model generates a computer program that when downloaded onto a robotic vehicle's on-board computer will guide the robot to successfully accomplish its task. Simulations of multiple robots engaged in problem-solving tasks have demonstrated cooperative behaviors. This report also discusses the behavior model produced by genetic programming and presents some results achieved during the study

  16. Genetic Testing and Its Implications: Human Genetics Researchers Grapple with Ethical Issues.

    Science.gov (United States)

    Rabino, Isaac

    2003-01-01

    Contributes systematic data on the attitudes of scientific experts who engage in human genetics research about the pros, cons, and ethical implications of genetic testing. Finds that they are highly supportive of voluntary testing and the right to know one's genetic heritage. Calls for greater genetic literacy. (Contains 87 references.) (Author/NB)

  17. Radon Research Program, FY 1992

    International Nuclear Information System (INIS)

    1993-04-01

    The United States Department of Energy, Office of Health and Environmental Research (DOE/OHER) is the principal federal agency conducting basic research related to indoor radon. The scientific information being sought in this program encompasses research designed to determine radon availability and transport outdoors, modeling transport into and within buildings, physics and chemistry of radon and radon progeny, dose response relationships, lung cancer risk, and mechanisms of radon carcinogenesis. There still remains a significant number of uncertainties in the currently available knowledge that is used to estimate lung cancer risk from exposure to environmental levels of radon and its progeny. The main goal of the DOE/OHER Radon Research Program is to develop information to reduce these uncertainties and thereby provide an improved health risk estimate of exposure to radon and its progeny and to identify and understand biological mechanisms of lung cancer development and required copollutants at low levels of exposure. Information useful in radon control strategies is also provided by the basic science undertaken in this program

  18. Genetics Education in Nurse Residency Programs: A Natural Fit.

    Science.gov (United States)

    Hamilton, Nalo M; Stenman, Christina W; Sang, Elaine; Palmer, Christina

    2017-08-01

    Scientific advances are shedding light on the genetic underpinning of common diseases. With such insight, the entire health care team is faced with the need to address patient questions regarding genetic risk, testing, and the psychosocial aspects of genetics information. Nurses are in a prime position to help with patient education about genetic conditions, yet they often lack adequate genetics education within their nursing curriculum to address patient questions and provide resources. One mechanism to address this knowledge deficit is the incorporation of a genetics-based curriculum into nurse residency programs. This article describes a novel genetics-based curriculum designed and implemented in the UCLA Health System Nurse Residency Program. J Contin Educ Nurs. 2017;48(8):379-384. Copyright 2017, SLACK Incorporated.

  19. Research and development program 1985

    International Nuclear Information System (INIS)

    1984-01-01

    In this report the research and development program of the GSI Darmstadt is described. It concerns heavy ion reactions, nuclear structure studies, exotic nuclei, nuclear theory, atomic collisions with heavy ions, atomic spectroscopy, the interaction of heavy ions with matter, atomic theory, biological studies with heavy ions, nuclear track techniques, UNILAC developments, acquisition of experimental data, and the development of new accelerators, ion sources, targets, and detectors. (HSI) [de

  20. Nuclear plant aging research program

    International Nuclear Information System (INIS)

    Eissenberg, D.M.

    1987-01-01

    The U.S. Nuclear Regulatory Commission, Office of Nuclear Regulatory Research, has established the Nuclear Plant Aging Research (NPAR) program in its Division of Engineering Technology. Principal contractors for this program include Oak Ridge National Laboratory, Brookhaven National Laboratory, Idaho National Engineering Laboratory, and Pacific Northwest Laboratory. The program goals are: to identify and characterize time-dependent degradation (aging) of nuclear plant safety-related electrical and mechanical components which could lead to loss of safety function; to identify and recommend methods for detecting and trending aging effects prior to loss of safety function so that timely maintenance can be implemented; and to recommend maintenance practices for mitigating the effects of aging. Research activities include prioritization of system and component aging in nuclear plants, characterization of aging degradation of specific components including identification of functional indicators useful for trending degradation, and testing of practical methods and devices for measuring the functional indicators. Aging assessments have been completed on electric motors, snubbers, motor-operated valves, and check valves. Testing of trending methods and devices for motor-operated valves and check valves is in progress

  1. Seventeen years of research on genetics of resistance to Aphanomyces root rot of pea

    Science.gov (United States)

    Aphanomyces root rot, caused by the oomycete Aphanomyces euteiches, is a major soil borne disease of pea in many countries. Genetic resistance is considered to be a main way to control the disease. Since 2000, INRA has engaged a long-term research program to study genetic resistance to A. euteiches ...

  2. Molecular research on the genetic diversity of Tunisian date palm ...

    African Journals Online (AJOL)

    Molecular research on the genetic diversity of Tunisian date palm ( Phoenix dactylifera L.) using the random amplified microsatellite polymorphism (RAMPO) and amplified fragment length polymorphism (AFLP) methods.

  3. Genetics researchers’ and iRB professionals’ attitudes toward genetic research review: a comparative analysis

    Science.gov (United States)

    Edwards, Karen L.; Lemke, Amy A.; Trinidad, Susan B.; Lewis, Susan M.; Starks, Helene; Snapinn, Katherine W.; Griffin, Mary Quinn; Wiesner, Georgia L.; Burke, Wylie

    2012-01-01

    Purpose Genetic research involving human participants can pose challenging questions related to ethical and regulatory standards for research oversight. However, few empirical studies describe how genetic researchers and institutional review board (IRB) professionals conceptualize ethical issues in genetic research or where common ground might exist. Methods Parallel online surveys collected information from human genetic researchers (n = 351) and IRB professionals (n = 208) regarding their views about human participant oversight for genetic protocols. Results A range of opinions were observed within groups on most issues. In both groups, a minority thought it likely that people would be harmed by participation in genetic research or identified from coded genetic data. A majority of both groups agreed that reconsent should be required for four of the six scenarios presented. Statistically significant differences were observed between groups on some issues, with more genetic researcher respondents trusting the confidentiality of coded data, fewer expecting harms from reidentification, and fewer considering reconsent necessary in certain scenarios. Conclusions The range of views observed within and between IRB and genetic researcher groups highlights the complexity and unsettled nature of many ethical issues in genome research. Our findings also identify areas where researcher and IRB views diverge and areas of common ground. PMID:22241102

  4. Parents' attitudes toward genetic research in autism spectrum disorder.

    Science.gov (United States)

    Johannessen, Jarle; Nærland, Terje; Bloss, Cinnamon; Rietschel, Marcella; Strohmaier, Jana; Gjevik, Elen; Heiberg, Arvid; Djurovic, Srdjan; Andreassen, Ole A

    2016-04-01

    Genetic research in autism spectrum disorder (ASD) is mainly performed in minors who are legally unable to provide consent. Thus, knowledge of the attitudes, fears, and expectations toward genetic research of the parents is important. Knowledge of the attitudes toward genetic research will improve cooperation between researchers and participants, and help establish confidence in ASD genetic research. The present study aimed to assess these attitudes. Questionnaire-based assessments of attitudes toward genetic research and toward procedures in genetic research of n=1455 parents of individuals with ASD were performed. The main motivation for participation in genetic research is to gain more knowledge of the causes and disease mechanisms of ASD (83.6%), and to contribute toward development of improved treatment in the future (63.7%). The parents also had a positive attitude towards storing genetic information (54.3%) and they requested confidentiality of data (82.9%) and expressed a need to be informed about the purpose (89%) and progress of the research (83.7%). We found a slightly more positive attitude to participation in genetic research among older parents (P=0.015), among fathers compared with mothers (P=0.01), among parents of girls compared with boys (P=0.03), and infantile autism compared with Asperger syndrome (P=0.002). However, linear regression analysis showed that parent and child characteristics seem to have too small an influence on attitudes toward genetic research to be of any relevance (R(2)=0.002-0.02). Parents of children with ASD have, in general, a very positive attitude toward genetic research. Data confidentiality is important, and they express a need for information on the purpose and progress of the research.

  5. Insect chromosomes preparing methods for genetic researches

    African Journals Online (AJOL)

    STORAGESEVER

    2009-01-05

    Jan 5, 2009 ... Ankara University Faculty of Science Department of Biology Tandogan Ankara Turkey. Accepted 21 ... intraspecific level; and the genetics evolution of the groups of .... Animal cytology and evolution Cambridge University. Press.

  6. Intelligent Flight Control Simulation Research Program

    National Research Council Canada - National Science Library

    Stolarik, Brian

    2007-01-01

    ...). Under the program, entitled "Intelligent Flight Control Simulation Research Laboratory," a variety of technologies were investigated or developed during the course of the research for AFRL/VAC...

  7. Improving Defense Health Program Medical Research Processes

    Science.gov (United States)

    2017-08-08

    research , including a Business Cell; 87 Research Development, 88 Research Oversight, 89 and Research Compliance offices;90 and the Center...needed for DHP medical research , such as the Army’s Clinical and Translational Research Program Office, 38 the Navy’s Research Methods Training Program... research stated, “key infrastructure for a learning health system will encompass three core elements: data networks, methods , and workforce.” 221

  8. Ethical genetic research in Indigenous communities: challenges and successful approaches.

    Science.gov (United States)

    McWhirter, Rebekah E; Mununggirritj, Djapirri; Marika, Dipililnga; Dickinson, Joanne L; Condon, John R

    2012-12-01

    Indigenous populations, in common with all populations, stand to benefit from the potential of genetic research to lead to improvements in diagnostic and therapeutic tools for a wide range of complex diseases. However, many Indigenous communities, especially ones that are isolated, are not included in genetic research efforts. This situation is largely a consequence of the challenges of ethically conducting genetic research in Indigenous communities and compounded by Indigenous peoples' negative past experiences with genetic issues. To examine ways of addressing these challenges, we review one investigation of a cancer cluster in remote Aboriginal communities in Arnhem Land, Australia. Our experiences demonstrate that genetic research can be both ethically and successfully conducted with Indigenous communities by respecting the authority of the community, involving community members, and including regular community review throughout the research process. Copyright © 2012 Elsevier Ltd. All rights reserved.

  9. Comprehensive bidding strategies with genetic programming/finite state automata

    International Nuclear Information System (INIS)

    Richter, C.W. Jr.; Sheble, G.B.; Ashlock, D.

    1999-01-01

    This research is an extension of the authors' previous work in double auctions aimed at developing bidding strategies for electric utilities which trade electricity competitively. The improvements detailed in this paper come from using data structures which combine genetic programming and finite state automata termed GP-Automata. The strategies developed by the method described here are adaptive--reacting to inputs--whereas the previously developed strategies were only suitable in the particular scenario for which they had been designed. The strategies encoded in the GP-Automata are tested in an auction simulator. The simulator pits them against other distribution companies (distcos) and generation companies (gencos), buying and selling power via double auctions implemented in regional commodity exchanges. The GP-Automata are evolved with a genetic algorithm so that they possess certain characteristics. In addition to designing successful bidding strategies (whose usage would result in higher profits) the resulting strategies can also be designed to imitate certain types of trading behaviors. The resulting strategies can be implemented directly in on-line trading, or can be used as realistic competitors in an off-line trading simulator

  10. The potential use of genetics to increase the effectiveness of treatment programs for criminal offenders.

    Science.gov (United States)

    Beaver, Kevin M; Jackson, Dylan B; Flesher, Dillon

    2014-01-01

    During the past couple of decades, the amount of research examining the genetic underpinnings to antisocial behaviors, including crime, has exploded. Findings from this body of work have generated a great deal of information linking genetics to criminal involvement. As a partial result, there is now a considerable amount of interest in how these findings should be integrated into the criminal justice system. In the current paper, we outline the potential ways that genetic information can be used to increase the effectiveness of treatment programs designed to reduce recidivism among offenders. We conclude by drawing attention to how genetic information can be used by rehabilitation programs to increase program effectiveness, reduce offender recidivism rates, and enhance public safety.

  11. Primer on molecular genetics. DOE Human Genome Program

    Energy Technology Data Exchange (ETDEWEB)

    1992-04-01

    This report is taken from the April 1992 draft of the DOE Human Genome 1991--1992 Program Report, which is expected to be published in May 1992. The primer is intended to be an introduction to basic principles of molecular genetics pertaining to the genome project. The material contained herein is not final and may be incomplete. Techniques of genetic mapping and DNA sequencing are described.

  12. Overview of the RERF scientific research program

    International Nuclear Information System (INIS)

    Bennett, B.G.

    2003-01-01

    Radiation Effects Research Foundation (RERF) was founded to study the effects of radiation in survivors of the atomic bombings of Hiroshima and Nagasaki. Several fixed cohorts or sub-cohorts were established to provide epidemiological and clinical data on the health status and mortality of survivors and their children. Genetics and radiobiological studies are carried out to help interpret the findings. The Life Span Study is the core project of RERF. It consists of a large cohort from a general population of both sexes and all ages, encompassing a wide range of accurately known doses and incorporating accurate disease incidence and mortality recording. These features make this a very valuable and informative study. The Adult Health Study is a clinical study of a sub-cohort of the Life Span Study. Examinations of survivors are conducted every two years, providing a continuing health profile of an aging population and establishing the radiation-related risk of non-cancer diseases. The children of atomic-bomb survivors are being studied to determine whether genetic effects might be apparent that could be related to parental exposures. Initial study of post-natal defects did not demonstrate discernable effects. The mortality follow up is continuing. A new clinical study of survivor children was recently started to examine the health condition of these now middle-aged individuals. It is now 58 years since the atomic bombings of Hiroshima and Nagasaki. The legacy of those events still marks the lives of the survivors. RERF feels an important responsibility to investigate the effects of radiation to contribute to the welfare of those affected, to understand and quantify the effects, and to provide a scientific basis for radiation protection worldwide. We intend to continue a high quality scientific research program into the future, establishing where possible more collaborative efforts to be sure that our shared resources and capabilities are most effectively utilized

  13. Genetic Research and Hungarian "Deep Ancestry"

    Directory of Open Access Journals (Sweden)

    Nándor Dreisziger

    2011-01-01

    Full Text Available The past few decades saw the birth of the new science of genetics that can be used not only for medical purposes but also for the study of the past. Geneticists were quick to begin applying this science to the examination of Hungarian history, especially the subject of Hungarian origins. The purpose of this paper is to acquaint the reader with some of these studies. One study this paper will examine is itself a review of the scientific literature of early genetic studies on Hungarian origins. Other studies evaluated in this paper will be the English-language scientific publications of a team of Hungarian geneticists who over the last several years have studied the genetic inter-relatedness of 10th century and present-day Hungarian populations in the Middle Danube Valley of Central Europe. The paper comes to the conclusion that while very early genetic inquiries into Hungarian origins were often fault-ridden and are of little use now, more recent studies suggest that the currently held explanations of Hungarian ethnogenesis — especially the story of the so-called Hungarian conquest of the late 9th century — might very well be subjected to a fundamental re-assessment.

  14. Genetics of Pseudococcusmicrocirculus on orchids RESEARCH

    Indian Academy of Sciences (India)

    Navya

    Genetic Structure of Pseudococcusmicrocirculus (Hemiptera: .... these orchids are listed as endangered on Florida's Regulated Plant Index (Coile and Garland 2003). .... other samples, which we did not have sufficient statistical power to detect. ... males and minute first instar nymphs can use wind currents for dispersal.

  15. Polyglot programming in applications used for genetic data analysis.

    Science.gov (United States)

    Nowak, Robert M

    2014-01-01

    Applications used for the analysis of genetic data process large volumes of data with complex algorithms. High performance, flexibility, and a user interface with a web browser are required by these solutions, which can be achieved by using multiple programming languages. In this study, I developed a freely available framework for building software to analyze genetic data, which uses C++, Python, JavaScript, and several libraries. This system was used to build a number of genetic data processing applications and it reduced the time and costs of development.

  16. Genetic programs can be compressed and autonomously decompressed in live cells

    Science.gov (United States)

    Lapique, Nicolas; Benenson, Yaakov

    2018-04-01

    Fundamental computer science concepts have inspired novel information-processing molecular systems in test tubes1-13 and genetically encoded circuits in live cells14-21. Recent research has shown that digital information storage in DNA, implemented using deep sequencing and conventional software, can approach the maximum Shannon information capacity22 of two bits per nucleotide23. In nature, DNA is used to store genetic programs, but the information content of the encoding rarely approaches this maximum24. We hypothesize that the biological function of a genetic program can be preserved while reducing the length of its DNA encoding and increasing the information content per nucleotide. Here we support this hypothesis by describing an experimental procedure for compressing a genetic program and its subsequent autonomous decompression and execution in human cells. As a test-bed we choose an RNAi cell classifier circuit25 that comprises redundant DNA sequences and is therefore amenable for compression, as are many other complex gene circuits15,18,26-28. In one example, we implement a compressed encoding of a ten-gene four-input AND gate circuit using only four genetic constructs. The compression principles applied to gene circuits can enable fitting complex genetic programs into DNA delivery vehicles with limited cargo capacity, and storing compressed and biologically inert programs in vivo for on-demand activation.

  17. Defense Nanotechnology Research and Development Program

    National Research Council Canada - National Science Library

    2007-01-01

    ...), Army Research Office (ARO) and the Air Force Office of Scientific Research (AFOSR)initiated numerous research and development programs focusing on advancing science and technology below one micron in size...

  18. Seismic safety margins research program overview

    International Nuclear Information System (INIS)

    Tokarz, F.J.; Smith, P.D.

    1978-01-01

    A multiyear seismic research program has been initiated at the Lawrence Livermore Laboratory. This program, the Seismic Safety Margins Research Program (SSMRP) is funded by the U.S. Nuclear Regulatory Commission, Office of Nuclear Regulatory Research. The program is designed to develop a probabilistic systems methodology for determining the seismic safety margins of nuclear power plants. Phase I, extending some 22 months, began in July 1978 at a funding level of approximately $4.3 million. Here we present an overview of the SSMRP. Included are discussions on the program objective, the approach to meet the program goal and objectives, end products, the probabilistic systems methodology, and planned activities for Phase I

  19. Program Leader | IDRC - International Development Research Centre

    International Development Research Centre (IDRC) Digital Library (Canada)

    Leads in the identification of the overall development research ... Ensures that a regional perspective is brought to bear on program planning at the PI and ... The incumbent is the manager of the Program Initiative program and team and as such: ... projects between Canadian and developing country researchers; and; When ...

  20. Algorithmic Trading with Developmental and Linear Genetic Programming

    Science.gov (United States)

    Wilson, Garnett; Banzhaf, Wolfgang

    A developmental co-evolutionary genetic programming approach (PAM DGP) and a standard linear genetic programming (LGP) stock trading systemare applied to a number of stocks across market sectors. Both GP techniques were found to be robust to market fluctuations and reactive to opportunities associated with stock price rise and fall, with PAMDGP generating notably greater profit in some stock trend scenarios. Both algorithms were very accurate at buying to achieve profit and selling to protect assets, while exhibiting bothmoderate trading activity and the ability to maximize or minimize investment as appropriate. The content of the trading rules produced by both algorithms are also examined in relation to stock price trend scenarios.

  1. Research for genetic instability of human genome

    Energy Technology Data Exchange (ETDEWEB)

    Hori, T.; Takahashi, E.; Tsuji, H.; Yamauchi, M. (National Inst. of Radiological Sciences, Chiba (Japan)); Murata, M.

    1992-01-01

    In the present review paper, the potential relevance of chromosomal fragile sites to carcinogenesis and mutagenesis is discussed based on our own and other's studies. Recent evidence indicate that fragile sites may act as predisposition factors involved in chromosomal instability of the human genome and that the sites may be preferential targets for various DNA damaging agents including ionizing radiation. It is also demonstrated that some critical genomic rearrangements at the fragile sites may contribute towards oncogenesis and that individuals carrying heritable form of fragile site may be at the risk. Although clinical significance of autosomal fragile sites has been a matter of discussion, a fragile site of the X chromosome is known to be associated with an X-linked genetic diseases, called fragile X syndrome. Molecular events leading to the fragile X syndrome have recently been elucidated. The fragile X genotype can be characterized by an increased amount of p(CCG)n repeat DNA sequence in the FMR-1 gene and the repeated sequences are shown to be unstable in both meiosis and mitosis. These repeats might exhibit higher mutation rate than is generally seen in the human genome. Further studies on the fragile sites in molecular biology and radiation biology will yield relevant data to the molecular mechanisms of genetic instability of the human genome as well as to better assessment of genetic effect of ionizing radiation. (author).

  2. Research for genetic instability of human genome

    International Nuclear Information System (INIS)

    Hori, T.; Takahashi, E.; Tsuji, H.; Yamauchi, M.; Murata, M.

    1992-01-01

    In the present review paper, the potential relevance of chromosomal fragile sites to carcinogenesis and mutagenesis is discussed based on our own and other's studies. Recent evidence indicate that fragile sites may act as predisposition factors involved in chromosomal instability of the human genome and that the sites may be preferential targets for various DNA damaging agents including ionizing radiation. It is also demonstrated that some critical genomic rearrangements at the fragile sites may contribute towards oncogenesis and that individuals carrying heritable form of fragile site may be at the risk. Although clinical significance of autosomal fragile sites has been a matter of discussion, a fragile site of the X chromosome is known to be associated with an X-linked genetic diseases, called fragile X syndrome. Molecular events leading to the fragile X syndrome have recently been elucidated. The fragile X genotype can be characterized by an increased amount of p(CCG)n repeat DNA sequence in the FMR-1 gene and the repeated sequences are shown to be unstable in both meiosis and mitosis. These repeats might exhibit higher mutation rate than is generally seen in the human genome. Further studies on the fragile sites in molecular biology and radiation biology will yield relevant data to the molecular mechanisms of genetic instability of the human genome as well as to better assessment of genetic effect of ionizing radiation. (author)

  3. Genetics in eating disorders: extending the boundaries of research

    Directory of Open Access Journals (Sweden)

    Andréa Poyastro Pinheiro

    2006-09-01

    Full Text Available OBJECTIVE: To review the recent literature relevant to genetic research in eating disorders and to discuss unique issues which are crucial for the development of a genetic research project in eating disorders in Brazil. METHOD: A computer literature review was conducted in the Medline database between 1984 and may 2005 with the search terms "eating disorders", "anorexia nervosa", "bulimia nervosa", "binge eating disorder", "family", "twin" and "molecular genetic" studies. RESULTS: Current research findings suggest a substantial influence of genetic factors on the liability to anorexia nervosa and bulimia nervosa. Genetic research with admixed populations should take into consideration sample size, density of genotyping and population stratification. Through admixture mapping it is possible to study the genetic structure of admixed human populations to localize genes that underlie ethnic variation in diseases or traits of interest. CONCLUSIONS: The development of a major collaborative genetics initiative of eating disorders in Brazil and South America would represent a realistic possibility of studying the genetics of eating disorders in the context of inter ethnic groups, and also integrate a new perspective on the biological etiology of eating disorders.

  4. Molecular research and genetic engineering of resistance to ...

    African Journals Online (AJOL)

    This paper reviews the recent research progress on genetic methods of resistance, the status and existing problems, traditional breeding, the main resistance mechanism, molecular markers and genetic engineering of resistance genes. It is hoped that new breeding methods and new varieties resistant to Verticillium wilt will ...

  5. LASL's FY 1978 supporting research program

    International Nuclear Information System (INIS)

    Hammel, E.F.; Merlan, S.J.; Freiwald, D.A.

    1978-09-01

    This report gives a brief overview of Los Alamos Scientific Laboratory's supporting research program, including philosophy, management and program analysis, funding, and a brief description of the kinds of work currently supported. 10 figures

  6. USNRC HTGR safety research program overview

    International Nuclear Information System (INIS)

    Foulds, R.B.

    1982-01-01

    An overview is given of current activities and planned research efforts of the US Nuclear Regulatory Commission (NRC) HTGR Safety Program. On-going research at Brookhaven National Laboratory, Oak Ridge National Laboratory, Los Alamos National Laboratory, and Pacific Northwest Laboratory are outlined. Tables include: HTGR Safety Issues, Program Tasks, HTGR Computer Code Library, and Milestones for Long Range Research Plan

  7. Programs of the Office of Energy Research

    International Nuclear Information System (INIS)

    1986-04-01

    The programs of the Office of Energy Research, DOE, include several thousand individual projects and hundreds of laboratories, universities, and other research facilities throughout the United States. The major programs and activities are described briefly, and include high energy and nuclear physics, fusion energy, basic energy sciences, and health and environmental research, as well as advisory, assessment, support, and scientific computing activities

  8. Gas Research Institute wetland research program

    International Nuclear Information System (INIS)

    Wilkey, P.L.; Zimmerman, R.E.; Isaacson, H.R.

    1992-01-01

    As part of three ongoing research projects, the Gas Research Institute (GRI) is studying the natural gas industry's impacts on wetlands and how to manage operations so that impacts can be minimized or eliminated. The objective of the first project is to gain a better understanding of the causes and processes of wetland loss in the Louisiana deltaic plain and what role gas pipeline canals play in wetland loss. On the basis of information gathered from the first projects, management and mitigation implications for pipeline construction and maintenance will be evaluated. The objective of the second project is to assess the floral and faunal communities on existing rights-of-way (ROWs) that pass through numerous types of wetlands across the United States. The emphasis of the project is on pipelines that were installed within the past five years. The objective of the third project is to evaluate the administrative, jurisdictional, technical, and economic issues of wetland mitigation banking. This paper discusses these projects, their backgrounds, some of the results to date, and the deliverables

  9. Non-linear nuclear engineering models as genetic programming application

    International Nuclear Information System (INIS)

    Domingos, Roberto P.; Schirru, Roberto; Martinez, Aquilino S.

    1997-01-01

    This work presents a Genetic Programming paradigm and a nuclear application. A field of Artificial Intelligence, based on the concepts of Species Evolution and Natural Selection, can be understood as a self-programming process where the computer is the main agent responsible for the discovery of a program able to solve a given problem. In the present case, the problem was to find a mathematical expression in symbolic form, able to express the existent relation between equivalent ratio of a fuel cell, the enrichment of fuel elements and the multiplication factor. Such expression would avoid repeatedly reactor physics codes execution for core optimization. The results were compared with those obtained by different techniques such as Neural Networks and Linear Multiple Regression. Genetic Programming has shown to present a performance as good as, and under some features superior to Neural Network and Linear Multiple Regression. (author). 10 refs., 8 figs., 1 tabs

  10. ANSTO - Program of Research 1993-1994

    International Nuclear Information System (INIS)

    1993-01-01

    The 1993-1994 Program of Research outlines ANSTO's scientific activities in four key research areas, Advanced Materials, Application of Nuclear Physics, Biomedicine and Health and Environmental Science. The effort has been channeled into applied research and development in partnership with industry and appropriate national and international institutions and into interdisciplinary strategic research projects to enhance the scientific base of the key research activities. A list of scientific publications originated from these program areas is also included. ills

  11. Molecular genetic researches on the radiation genetics of Drosophila in JINR

    International Nuclear Information System (INIS)

    Afanas'eva, K.P.; Aleksandrova, M.V.; Aleksandrov, I.D.

    2016-01-01

    Molecular genetic studies of radiation-induced heritable DNA lesions are carried out by the genetic group of Laboratory of nuclear problem in Joint Institute for Nuclear Research. The first results of molecular analysis of γ –ray- and neutron-induced vestigial mutations using PCR and sequencing will be presented. (authors)

  12. NIH Researchers Find Potential Genetic Cause of Cushing Syndrome

    Science.gov (United States)

    ... 2017 NIH researchers find potential genetic cause of Cushing syndrome Finding may lead to therapies that prevent pituitary ... mutations in the gene CABLES1 may lead to Cushing syndrome, a rare disorder in which the body overproduces ...

  13. Safety research program of NUCEF

    International Nuclear Information System (INIS)

    Naito, Y.

    1996-01-01

    To contribute the safety and establishment of advanced technologies in the area of nuclear fuel cycle, Japan Atomic Energy Research Institute (JAERI) has constructed a new research facility NUCEF (Nuclear Fuel Cycle Safety Engineering Research Facility) as the center for the research and development, particularly on the reprocessing technology and transuranium (TRU) waste management. NUCEF consist of three buildings, administration building, experiment building A and B. Building A has two experiment facilities STACY (Static Experiment Critical Facility) and TRACY (Transient Experiment Critical Facility). The experiment building B is referred to as BECKY (Back-end Fuel Cycle Key Elements Research Facility). Researches on the reprocessing and the waste management are carried out with spent fuels, high-level liquid waste, TRU etc. in the α γ cell and glove boxes. NUCEF was constructed with the following aims. Using STACY and TRACY, are aimed, (1) research on advanced technology for criticality safety control, (2) reconfirmation of criticality safety margin of the Rokkasho reprocessing plant. Using BECKY, are aimed, (1) research on advanced technology of reprocessing process, (2) contribution to develop the scenario for TRU waste disposal, (3) development of new technology for TRU partitioning and volume reduction of radioactive waste. To realize the above aims, following 5 research subjects are settled in NUCEF, (1) Criticality safety research, (2) Research on safety and advanced technology of fuel reprocessing, (3) Research on TRU waste management, (4) Fundamental research on TRU chemistry, (5) Key technology development for TRU processing. (author)

  14. Feature extraction from multiple data sources using genetic programming.

    Energy Technology Data Exchange (ETDEWEB)

    Szymanski, J. J. (John J.); Brumby, Steven P.; Pope, P. A. (Paul A.); Eads, D. R. (Damian R.); Galassi, M. C. (Mark C.); Harvey, N. R. (Neal R.); Perkins, S. J. (Simon J.); Porter, R. B. (Reid B.); Theiler, J. P. (James P.); Young, A. C. (Aaron Cody); Bloch, J. J. (Jeffrey J.); David, N. A. (Nancy A.); Esch-Mosher, D. M. (Diana M.)

    2002-01-01

    Feature extration from imagery is an important and long-standing problem in remote sensing. In this paper, we report on work using genetic programming to perform feature extraction simultaneously from multispectral and digital elevation model (DEM) data. The tool used is the GENetic Imagery Exploitation (GENIE) software, which produces image-processing software that inherently combines spatial and spectral processing. GENIE is particularly useful in exploratory studies of imagery, such as one often does in combining data from multiple sources. The user trains the software by painting the feature of interest with a simple graphical user interface. GENIE then uses genetic programming techniques to produce an image-processing pipeline. Here, we demonstrate evolution of image processing algorithms that extract a range of land-cover features including towns, grasslands, wild fire burn scars, and several types of forest. We use imagery from the DOE/NNSA Multispectral Thermal Imager (MTI) spacecraft, fused with USGS 1:24000 scale DEM data.

  15. Future needs in research on genetic sexing of Ceratitis capitata

    International Nuclear Information System (INIS)

    Seawright, J.A.

    1997-01-01

    The author makes suggestions on the direction of research for genetic sexing over the next several years and prepared the paper as a guide for discussion. The literature of genetic and cytogenetic studies on insects as a whole is the basis for most of the approaches that the genetic control community has used, but only a tiny fraction of the literature is directed at genetic sexing and most of that is limited to, small scale laboratory studies. The effort to use genetic sexing strains on the scale of mass rearing of medflies is unprecedented, and it is not surprising that a few problems have been encountered during implementation. Consideration of this fact leads to the conclusion that it is necessary to 'think big' and target the research. (author)

  16. Seismic safety research program plan

    International Nuclear Information System (INIS)

    1985-06-01

    This plan describes the safety issues, regulatory needs, and the research necessary to address these needs. The plan also discusses the relationship between current and proposed research within the NRC and research sponsored by other government agencies, universities, industry groups, professional societies, and foreign sources

  17. HSE Nuclear Safety Research Program

    Energy Technology Data Exchange (ETDEWEB)

    Bagley, M.J. [Health and Safety Executive, Sheffield (United Kingdom)

    1995-12-31

    HSE funds two programmes of nuclear safety research: a programme of {approx} 2.2M of extramural research to support the Nuclear Safety Division`s regulatory activities and a programme of {approx} 11M of generic safety research managed by the Nuclear Safety Research Management Unit (NSRMU) in Sheffield, UK. This paper is concerned only with the latter programme; it describes how it is planned and procured and outlines some of the work on structural integrity problems. It also describes the changes that are taking place in the way nuclear safety research is procured in the UK. (author).

  18. HSE Nuclear Safety Research Program

    International Nuclear Information System (INIS)

    Bagley, M.J.

    1995-01-01

    HSE funds two programmes of nuclear safety research: a programme of ∼ 2.2M of extramural research to support the Nuclear Safety Division's regulatory activities and a programme of ∼ 11M of generic safety research managed by the Nuclear Safety Research Management Unit (NSRMU) in Sheffield, UK. This paper is concerned only with the latter programme; it describes how it is planned and procured and outlines some of the work on structural integrity problems. It also describes the changes that are taking place in the way nuclear safety research is procured in the UK. (author)

  19. Seismic safety research program plan

    International Nuclear Information System (INIS)

    1987-05-01

    This document presents a plan for seismic research to be performed by the Structural and Seismic Engineering Branch in the Office of Nuclear Regulatory Research. The plan describes the regulatory needs and related research necessary to address the following issues: uncertainties in seismic hazard, earthquakes larger than the design basis, seismic vulnerabilities, shifts in building frequency, piping design, and the adequacy of current criteria and methods. In addition to presenting current and proposed research within the NRC, the plan discusses research sponsored by other domestic and foreign sources

  20. [Ethical challenges of genetic manipulation and research with animals].

    Science.gov (United States)

    Rodríguez Yunta, Eduardo

    2012-01-01

    Research with animals presents ethical questions both for being used as models of human diseases and for being a prerequisite for trials in humans, as in the introduction of genetic modifications. Some of these questions refer to the fact that, as models, they do not fully represent the human condition; that conducting toxicity tests causes great harm to animals; that their nature is altered by genetic modifications and that introducing genetically modified organisms is a risk. The use of animals in research for the benefit of humans imposes the moral responsibility to respect them, not making them suffer unnecessarily, since they are living beings capable of feeling.

  1. Consulting the community: public expectations and attitudes about genetics research

    Science.gov (United States)

    Etchegary, Holly; Green, Jane; Dicks, Elizabeth; Pullman, Daryl; Street, Catherine; Parfrey, Patrick

    2013-01-01

    Genomic discoveries and technologies promise numerous opportunities for improving health. Key to these potential health improvements, however, are health-care consumers' understanding and acceptance of these new developments. We identified community groups and invited them to a public information-consultation session in order to explore public awareness, perception and expectations about genetics and genomics research. One hundred and four members of seven community groups in Newfoundland, Canada took part in the community sessions. Content analysis of participant comments revealed they were largely hopeful about genetics research in its capacity to improve health; however, they did not accept such research uncritically. Complex issues arose during the community consultations, including the place of genetics in primary care, the value of genetics for personal health, and concerns about access to and uses of genetic information. Participants unequivocally endorsed the value of public engagement with these issues. The rapid pace of discoveries in genomics research offers exciting opportunities to improve population health. However, public support will be crucial to realize health improvements. Our findings suggest that regular, transparent dialog between researchers and the public could allow a greater understanding of the research process, as well as assist in the design of efficient and effective genetic health services, informed by the public that will use them. PMID:23591403

  2. Genetic testing and its implications: human genetics researchers grapple with ethical issues.

    Science.gov (United States)

    Rabino, Isaac

    2003-01-01

    To better understand ethical issues involved in the field of human genetics and promote debate within the scientific community, the author surveyed scientists who engage in human genetics research about the pros, cons, and ethical implications of genetic testing. This study contributes systematic data on attitudes of scientific experts. The survey finds respondents are highly supportive of voluntary testing and the right to know one's genetic heritage. The majority consider in utero testing and consequent pregnancy termination acceptable for cases involving likelihood of serious disease but disapprove for genetic reasons they consider arbitrary, leaving a gray area of distinguishing between treatment of disorders and enhancement still to be resolved. While safeguarding patient confidentiality versus protecting at-risk third parties (kin, reproductive partners) presents a dilemma, preserving privacy from misuse by institutional third parties (employers, insurers) garners strong consensus for legislation against discrimination. Finally, a call is made for greater genetic literacy.

  3. A Hybrid Genetic Programming Algorithm for Automated Design of Dispatching Rules.

    Science.gov (United States)

    Nguyen, Su; Mei, Yi; Xue, Bing; Zhang, Mengjie

    2018-06-04

    Designing effective dispatching rules for production systems is a difficult and timeconsuming task if it is done manually. In the last decade, the growth of computing power, advanced machine learning, and optimisation techniques has made the automated design of dispatching rules possible and automatically discovered rules are competitive or outperform existing rules developed by researchers. Genetic programming is one of the most popular approaches to discovering dispatching rules in the literature, especially for complex production systems. However, the large heuristic search space may restrict genetic programming from finding near optimal dispatching rules. This paper develops a new hybrid genetic programming algorithm for dynamic job shop scheduling based on a new representation, a new local search heuristic, and efficient fitness evaluators. Experiments show that the new method is effective regarding the quality of evolved rules. Moreover, evolved rules are also significantly smaller and contain more relevant attributes.

  4. Gas Research Institute research program summary: Goals and accomplishments

    International Nuclear Information System (INIS)

    1991-07-01

    Gas Research Institute's research and development programs pursue technologies that maximize the value of gas energy services while minimizing the cost of supplying and delivering gaseous fuels. Four program areas, Supply Options, End Use, Gas Operations, and Crosscutting Research, are described in the report, together with related project titles and numbers. Also included are summaries of 1990 research results, research collaboration and supported work, and patents and licensing agreements. Glossaries of budget and program terms and of acronyms and abbreviations often used in the GRI literature are added

  5. Programs of the Office of Energy Research

    International Nuclear Information System (INIS)

    1984-04-01

    An overview is given for the DOE research programs in high energy and nuclear physics; fusion energy; basic energy sciences; health and environmental research; and advisory, assessment and support activities

  6. AECL research programs in chemistry

    International Nuclear Information System (INIS)

    Crocker, I.H.; Eastwood, T.A.; Smith, D.R.; Stewart, R.B.; Tomlinson, M.; Torgerson, D.F.

    1980-09-01

    Fundamental or underlying research in chemistry is being done in AECL laboratories to further the understanding of processes involved in current nuclear energy systems and maintain an awareness of progress at the frontiers of chemical research so that new advances can be turned to advantage in future AECL endeavours. The report introduces the current research topics and describes them briefly under the following headings: radiation chemistry, isotope separation, high temperature solution chemistry, fuel reprocessing chemistry, and analytical chemistry. (auth)

  7. Estimates of genetic parameters, genetic trends, and inbreeding in a crossbred dairy sheep research flock in the United States.

    Science.gov (United States)

    Murphy, T W; Berger, Y M; Holman, P W; Baldin, M; Burgett, R L; Thomas, D L

    2017-10-01

    For the past 2 decades, the Spooner Agriculture Research Station (ARS) of the University of Wisconsin-Madison operated the only dairy sheep research flock in North America. The objectives of the present study were to 1) obtain estimates of genetic parameters for lactation and reproductive traits in dairy ewes, 2) estimate the amount of genetic change in these traits over time, and 3) quantify the level of inbreeding in this flock over the last 20 yr. Multiple-trait repeatability models (MTRM) were used to analyze ewe traits through their first 6 parities. The first MTRM jointly analyzed milk (180-d-adjusted milk yield [180d MY]), fat (180-d-adjusted fat yield [180d FY]), and protein (180-d-adjusted protein yield [180d PY]) yields adjusted to 180 d of lactation; number of lambs born per ewe lambing (NLB); and lactation average test-day somatic cell score (LSCS). A second MTRM analyzed 180d MY, NLB, LSCS, and percentage milk fat (%F) and percentage milk protein (%P). The 3 yield traits were moderately heritable (0.26 to 0.32) and strongly genetically correlated (0.91 to 0.96). Percentage milk fat and %P were highly heritable (0.53 and 0.61, respectively) and moderately genetically correlated (0.61). Milk yield adjusted to 180 d was negatively genetically correlated with %F and %P (-0.31 and -0.34, respectively). Ewe prolificacy was not significantly ( > 0.67) genetically correlated with yield traits, %P, or LSCS but lowly negatively correlated with %F (-0.26). Lactation somatic cell score was unfavorably genetically correlated with yield traits (0.28 to 0.39) but not significantly ( > 0.09) correlated with %F, %P, and NLB. Within-trait multiple-trait models through the first 4 parities revealed that 180d MY, 180d FY, 180d PY, %F, and %P were strongly genetically correlated across parity (0.67 to 1.00). However, the genetic correlations across parity for NLB and LSCS were somewhat lower (0.51 to 0.96). Regressing predicted breeding values for 180d MY, without and with

  8. Animal Resource Program | Center for Cancer Research

    Science.gov (United States)

    CCR Animal Resource Program The CCR Animal Resource Program plans, develops, and coordinates laboratory animal resources for CCR’s research programs. We also provide training, imaging, and technology development in support of moving basic discoveries to the clinic. The ARP Manager:

  9. Animal Resource Program | Center for Cancer Research

    Science.gov (United States)

    CCR Animal Resource Program The CCR Animal Resource Program plans, develops, and coordinates laboratory animal resources for CCR’s research programs. We also provide training, imaging, and technology development in support of moving basic discoveries to the clinic. The ARP Office:

  10. Human genome and genetic sequencing research and informed consent

    International Nuclear Information System (INIS)

    Iwakawa, Mayumi

    2003-01-01

    On March 29, 2001, the Ethical Guidelines for Human Genome and Genetic Sequencing Research were established. They have intended to serve as ethical guidelines for all human genome and genetic sequencing research practice, for the purpose of upholding respect for human dignity and rights and enforcing use of proper methods in the pursuit of human genome and genetic sequencing research, with the understanding and cooperation of the public. The RadGenomics Project has prepared a research protocol and informed consent document that follow these ethical guidelines. We have endeavored to protect the privacy of individual information, and have established a procedure for examination of research practices by an ethics committee. Here we report our procedure in order to offer this concept to the patients. (authors)

  11. Accreditation to manage research programs

    International Nuclear Information System (INIS)

    Miramand, Pierre

    1993-01-01

    In this report for an accreditation to supervise research, the author proposes an overview of a study of transfers of vanadium towards benthic organisms (i.e. the toxicity of vanadium for sea coastal organisms), of studies of transfer of transuranic elements from sediment to marine benthic species. He presents current researches and perspectives: study of the level of metallic pollutants and physical-chemical characteristics of coastal waters in northern Cotentin, researches in Seine Bay, study of pollution biologic indicators. Numerous articles are provided in appendix

  12. Prostate Cancer Research Training Program

    Science.gov (United States)

    2017-09-01

    pathways underlying pathological cell proliferation in the setting of cancer. Current efforts are focused on selecting RNA aptamers to antigens...of restaurants ranging from fast food to fine dining. Application to the Program - Application forms, distributed with this brochure...pathological cell proliferation in the setting of cancer. Current efforts are focused on selecting RNA aptamers to antigens expressed on the surface of target

  13. Military Vision Research Program. Addendum

    Science.gov (United States)

    2011-08-01

    Vis Sci. 52(9):6174-6180. 4. Zoukhri, D. 2006. Effect of inflammation on lacrimal gland function . Exp Eye Res. 82(5):885-898. 5. Nakamura, S., M...GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT NUMBER 5e. TASK NUMBER E-Mail: 5f. WORK UNIT NUMBER 7. PERFORMING...NOMID), and they are collectively referred to as the cryopyrin/NALP3- associated periodic syndromes (CAPS). Functional studies revealed that the

  14. Research and Development Conference CIEE Program 1992

    Energy Technology Data Exchange (ETDEWEB)

    1992-11-01

    CIEE`s second annual Research and Development Conference will introduce you to some of the results achieved to date through CIEE-sponsored multiyear research performed in three programs: Building Energy Efficiency, Air Quality Impacts of Energy Efficiency, and End-Use Resource Planning. Results from scoping studies, Director`s discretionary research, and exploratory research will also be featured in this report.

  15. Aquatic Plant Control Research Program

    National Research Council Canada - National Science Library

    Cofrancesco, Alfred

    1998-01-01

    .... This search for natural plant enemies (insects and fungal pathogens) has led researchers to the native ranges of noxious aquatic plants, located throughout the continents of Africa, Asia, Europe, and Australia...

  16. Maryland controlled fusion research program

    International Nuclear Information System (INIS)

    Griem, H.R.; Liu, C.S.

    1992-01-01

    In this paper, we summarize the technical progress in four major areas of tokamak research: (a) L/H transition and edge turbulence and transport; (b) active control of microturbulence and transport; (c) major disruptions; and (d) the sawtooth crash

  17. Understanding participation by African Americans in cancer genetics research.

    Science.gov (United States)

    McDonald, Jasmine A; Barg, Frances K; Weathers, Benita; Guerra, Carmen E; Troxel, Andrea B; Domchek, Susan; Bowen, Deborah; Shea, Judy A; Halbert, Chanita Hughes

    2012-01-01

    Understanding genetic factors that contribute to racial differences in cancer outcomes may reduce racial disparities in cancer morbidity and mortality. Achieving this goal will be limited by low rates of African American participation in cancer genetics research. We conducted a qualitative study with African American adults (n = 91) to understand attitudes about participating in cancer genetics research and to identify factors that are considered when making a decision about participating in this type of research. Participants would consider the potential benefits to themselves, family members, and their community when making a decision to participate in cancer genetics research. However, concerns about exploitation, distrust of researchers, and investigators' motives were also important to participation decisions. Individuals would also consider who has access to their personal information and what would happen to these data. Side effects, logistical issues, and the potential to gain knowledge about health issues were also described as important factors in decision making. African Americans may consider a number of ethical, legal, and social issues when making a decision to participate in cancer genetics research. These issues should be addressed as part of recruitment efforts.

  18. Lewis' Educational and Research Collaborative Internship Program

    Science.gov (United States)

    Heyward, Ann; Gott, Susan (Technical Monitor)

    2004-01-01

    The Lewis Educational and Research Collaborative Internship Program (LERCIP) is a collaborative undertaking by the Office of Educational Programs at NASA Glenn Research Center at Lewis Field (formerly NASA Lewis Research Center) and the Ohio Aerospace Institute. This program provides 10-week internships in addition to summer and winter extensions if funding is available and/or is requested by mentor (no less than 1 week no more than 4 weeks) for undergraduate/graduate students and secondary school teachers. Students who meet the travel reimbursement criteria receive up to $500 for travel expenses. Approximately 178 interns are selected to participate in this program each year and begin arriving the fourth week in May. The internships provide students with introductory professional experiences to complement their academic programs. The interns are given assignments on research and development projects under the personal guidance of NASA professional staff members. Each intern is assigned a NASA mentor who facilitates a research assignment. In addition to the research assignment, the summer program includes a strong educational component that enhances the professional stature of the participants. The educational activities include a research symposium and a variety of workshops, and lectures. An important aspect of the program is that it includes students with diverse social, cultural and economic backgrounds. The purpose of this report is to document the program accomplishments for 2004.

  19. Physical Research Program: research contracts and statistical summary

    International Nuclear Information System (INIS)

    1975-01-01

    The physical research program consists of fundamental theoretical and experimental investigations designed to support the objectives of ERDA. The program is directed toward discovery of natural laws and new knowledge, and to improved understanding of the physical sciences as related to the development, use, and control of energy. The ultimate goal is to develop a scientific underlay for the overall ERDA effort and the fundamental principles of natural phenomena so that these phenomena may be understood and new principles, formulated. The physical research program is organized into four functional subprograms, high-energy physics, nuclear sciences, materials sciences, and molecular sciences. Approximately four-fifths of the total physical research program costs are associated with research conducted in ERDA-owned, contractor-operated federally funded research and development centers. A little less than one-fifth of the costs are associated with the support of research conducted in other laboratories

  20. Sports genetics moving forward: lessons learned from medical research.

    Science.gov (United States)

    Mattsson, C Mikael; Wheeler, Matthew T; Waggott, Daryl; Caleshu, Colleen; Ashley, Euan A

    2016-03-01

    Sports genetics can take advantage of lessons learned from human disease genetics. By righting past mistakes and increasing scientific rigor, we can magnify the breadth and depth of knowledge in the field. We present an outline of challenges facing sports genetics in the light of experiences from medical research. Sports performance is complex, resulting from a combination of a wide variety of different traits and attributes. Improving sports genetics will foremost require analyses based on detailed phenotyping. To find widely valid, reproducible common variants associated with athletic phenotypes, study sample sizes must be dramatically increased. One paradox is that in order to confirm relevance, replications in specific populations must be undertaken. Family studies of athletes may facilitate the discovery of rare variants with large effects on athletic phenotypes. The complexity of the human genome, combined with the complexity of athletic phenotypes, will require additional metadata and biological validation to identify a comprehensive set of genes involved. Analysis of personal genetic and multiomic profiles contribute to our conceptualization of precision medicine; the same will be the case in precision sports science. In the refinement of sports genetics it is essential to evaluate similarities and differences between sexes and among ethnicities. Sports genetics to date have been hampered by small sample sizes and biased methodology, which can lead to erroneous associations and overestimation of effect sizes. Consequently, currently available genetic tests based on these inherently limited data cannot predict athletic performance with any accuracy. Copyright © 2016 the American Physiological Society.

  1. 2016 Research Outreach Program report

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Hye Young [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Kim, Yangkyu [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2016-10-13

    This paper is the research activity report for 4 weeks in LANL. Under the guidance of Dr. Lee, who performs nuclear physics research at LANSCE, LANL, I studied the Low Energy NZ (LENZ) setup and how to use the LENZ. First, I studied the LENZ chamber and Si detectors, and worked on detector calibrations, using the computer software, ROOT (CERN developed data analysis tool) and EXCEL (Microsoft office software). I also performed the calibration experiments that measure alpha particles emitted from a Th-229 source by using a S1-type detector (Si detector). And with Dr. Lee, we checked the result.

  2. Forecasting Shaharchay River Flow in Lake Urmia Basin using Genetic Programming and M5 Model Tree

    Directory of Open Access Journals (Sweden)

    S. Samadianfard

    2017-01-01

    analytical formulations did not have positive effect in reducing prediction error. Unlike the previous observed trend, in case of predicting river flows with Q Q, the genetic programming method with root mean squared error of 3.3501 in comparison with M5 model trees with error of 3.8480 had more satisfied performance. Finally, in the case of predicting river flows with Q, Q,Q, the genetic programming method with root mean squared error of 3.3094 in comparison with M5 model trees with error of 3.5514 presented better predictions. As a result, it can be stated that genetic programming by the best mathematical functions and considering the input parameters of Q,Q,Q, by resulting less root mean squared error and high correlation coefficients had the best performances among others. Also, the results showed that adding more trigonometric functions did not improve the precisions of the predictions. Conclusion: In this research, the intelligent models such as genetic programming and M5 model trees have been used for prediction of monthly flows of Shaharchay River located in East Azerbaijan, Iran. The obtained results showed that the genetic programming by the best mathematical functions and M5 model trees in case of considering the input parameters of Q,Q,Q, by less root mean squared error had the best performances in river flow predictions. As a conclusion, the genetic programming method by specific mathematical functions including four basic operations, logarithm, power and using input parameters of Q,Q,Q, has been proposed as the best and precise model for predicting Shaharchay River flows.

  3. Tracking the Genetic Stability of a Honey Bee (Hymenoptera: Apidae) Breeding Program With Genetic Markers.

    Science.gov (United States)

    Bourgeois, Lelania; Beaman, Lorraine

    2017-08-01

    A genetic stock identification (GSI) assay was developed in 2008 to distinguish Russian honey bees from other honey bee stocks that are commercially produced in the United States. Probability of assignment (POA) values have been collected and maintained since the stock release in 2008 to the Russian Honey Bee Breeders Association. These data were used to assess stability of the breeding program and the diversity levels of the contemporary breeding stock through comparison of POA values and genetic diversity parameters from the initial release to current values. POA values fluctuated throughout 2010-2016, but have recovered to statistically similar levels in 2016 (POA(2010) = 0.82, POA(2016) = 0.74; P = 0.33). Genetic diversity parameters (i.e., allelic richness and gene diversity) in 2016 also remained at similar levels when compared to those in 2010. Estimates of genetic structure revealed stability (FST(2009/2016) = 0.0058) with a small increase in the estimate of the inbreeding coefficient (FIS(2010) = 0.078, FIS(2016) = 0.149). The relationship among breeding lines, based on genetic distance measurement, was similar in 2008 and 2016 populations, but with increased homogeneity among lines (i.e., decreased genetic distance). This was expected based on the closed breeding system used for Russian honey bees. The successful application of the GSI assay in a commercial breeding program demonstrates the utility and stability of such technology to contribute to and monitor the genetic integrity of a breeding stock of an insect species. Published by Oxford University Press on behalf of Entomological Society of America 2017. This work is written by US Government employees and is in the public domain in the US.

  4. Different differences: The use of ‘genetic ancestry’ versus race in biomedical human genetic research

    Science.gov (United States)

    Fujimura, Joan H.; Rajagopalan, Ramya

    2011-01-01

    This article presents findings from our ethnographic research on biomedical scientists’ studies of human genetic variation and common complex disease. We examine the socio-material work involved in genome-wide association studies (GWAS) and discuss whether, how, and when notions of race and ethnicity are or are not used. We analyze how researchers produce simultaneously different kinds of populations and population differences. Although many geneticists use race in their analyses, we find some who have invented a statistical genetics method and associated software that they use specifically to avoid using categories of race in their genetics analysis. Their method allows them to operationalize their concept of ‘genetic ancestry’ without resorting to notions of race and ethnicity. We focus on the construction and implementation of the software’s algorithms, and discuss the consequences and implications of the software technology for debates and policies around the use of race in genetics research. We also demonstrate that the production and use of their method involves a dynamic and fluid assemblage of actors in various disciplines responding to disciplinary and sociopolitical contexts and concerns. This assemblage also includes particular discourses on human history and geography as they become entangled with research on genetic markers and disease. We introduce the concept of ‘genome geography’, to analyze how some researchers studying human genetic variation ‘locate’ stretches of DNA in different places and times. The concept of genetic ancestry and the practice of genome geography rely on old discourses, but they also incorporate new technologies, infrastructures, and political and scientific commitments. Some of these new technologies provide opportunities to change some of our institutional and cultural forms and frames around notions of difference and similarity. Neverthless, we also highlight the slipperiness of genome geography and the

  5. A genetic programming approach to oral cancer prognosis

    Directory of Open Access Journals (Sweden)

    Mei Sze Tan

    2016-09-01

    Full Text Available Background The potential of genetic programming (GP on various fields has been attained in recent years. In bio-medical field, many researches in GP are focused on the recognition of cancerous cells and also on gene expression profiling data. In this research, the aim is to study the performance of GP on the survival prediction of a small sample size of oral cancer prognosis dataset, which is the first study in the field of oral cancer prognosis. Method GP is applied on an oral cancer dataset that contains 31 cases collected from the Malaysia Oral Cancer Database and Tissue Bank System (MOCDTBS. The feature subsets that is automatically selected through GP were noted and the influences of this subset on the results of GP were recorded. In addition, a comparison between the GP performance and that of the Support Vector Machine (SVM and logistic regression (LR are also done in order to verify the predictive capabilities of the GP. Result The result shows that GP performed the best (average accuracy of 83.87% and average AUROC of 0.8341 when the features selected are smoking, drinking, chewing, histological differentiation of SCC, and oncogene p63. In addition, based on the comparison results, we found that the GP outperformed the SVM and LR in oral cancer prognosis. Discussion Some of the features in the dataset are found to be statistically co-related. This is because the accuracy of the GP prediction drops when one of the feature in the best feature subset is excluded. Thus, GP provides an automatic feature selection function, which chooses features that are highly correlated to the prognosis of oral cancer. This makes GP an ideal prediction model for cancer clinical and genomic data that can be used to aid physicians in their decision making stage of diagnosis or prognosis.

  6. A genetic programming approach to oral cancer prognosis.

    Science.gov (United States)

    Tan, Mei Sze; Tan, Jing Wei; Chang, Siow-Wee; Yap, Hwa Jen; Abdul Kareem, Sameem; Zain, Rosnah Binti

    2016-01-01

    The potential of genetic programming (GP) on various fields has been attained in recent years. In bio-medical field, many researches in GP are focused on the recognition of cancerous cells and also on gene expression profiling data. In this research, the aim is to study the performance of GP on the survival prediction of a small sample size of oral cancer prognosis dataset, which is the first study in the field of oral cancer prognosis. GP is applied on an oral cancer dataset that contains 31 cases collected from the Malaysia Oral Cancer Database and Tissue Bank System (MOCDTBS). The feature subsets that is automatically selected through GP were noted and the influences of this subset on the results of GP were recorded. In addition, a comparison between the GP performance and that of the Support Vector Machine (SVM) and logistic regression (LR) are also done in order to verify the predictive capabilities of the GP. The result shows that GP performed the best (average accuracy of 83.87% and average AUROC of 0.8341) when the features selected are smoking, drinking, chewing, histological differentiation of SCC, and oncogene p63. In addition, based on the comparison results, we found that the GP outperformed the SVM and LR in oral cancer prognosis. Some of the features in the dataset are found to be statistically co-related. This is because the accuracy of the GP prediction drops when one of the feature in the best feature subset is excluded. Thus, GP provides an automatic feature selection function, which chooses features that are highly correlated to the prognosis of oral cancer. This makes GP an ideal prediction model for cancer clinical and genomic data that can be used to aid physicians in their decision making stage of diagnosis or prognosis.

  7. Overview of Gas Research Institute environmental research programs

    International Nuclear Information System (INIS)

    Evans, J.M.

    1991-01-01

    The Gas Research Institute (GRI) is a private not-for-profit membership organization of natural gas pipelines, distribution companies and natural gas producers. GRI's purpose is to plan, to manage and to develop financing for a gas-related research and development (R and D) program on behalf of its members and their customers. GRI does not do any research itself. GRI's R and D program is designed to provide advanced technologies for natural gas supply, transport, storage, distribution and end-use applications in all markets. In addition, basic research is conducted for GRI in these areas to build a foundation for future technology breakthroughs. Work in the Environment and Safety Research Department includes sections interested in: supply related research, air quality research, end use equipment safety research, gas operations safety research, and gas operations environmental research. The Natural Gas Supply Program has research ongoing in such areas as: restoration of pipeline right-of-ways; cleaning up town gas manufacturing sites; the development of methanogenic bacteria for soil and groundwater cleanup; development of biological fluidized carbon units for rapid destruction of carbonaceous compounds; research on liquid redox sulfur recovery for sulfur removal from natural gas; research on produced water and production wastes generated by the natural gas industry; environmental effects of coalbed methane production; and subsurface effects of natural gas operations. The western coalbed methane and ground water programs are described

  8. Nursing research programs gather strength in Australia.

    Science.gov (United States)

    Borbasi, Sally; Emden, Carolyn; Jackson, Debra

    2005-04-01

    To shed light on programmatic research through direct experience is highly beneficial to nursing scholarship. Following a recent description of a successful Australian program of research centered around people's chronic illness experience we are inspired to continue the commentary (Koch et al 2005). Koch et al's (2005) case study reported on several 'core elements' they believe have contributed to the growth and effectiveness of their program. In this paper we consider some of these in light of current literature and our own challenging experiences within several Australian universities. Koch et al (2005) also makes a not too subtle distinction between dedicated research units independent of universities and research programs emanating from academia, suggesting the former are more productive. While one of the authors in the above paper, a UK scholar and nursing academic, makes interesting observations about this assertion, we contend that his UK perspective fails to capture the urgency of establishing nursing research programs in Australian universities. Consequently, we have chosen to extend the discussion about nursing research programs from the perspective of Australian academe, including comment on building productive relationships, strengthening a track record, research and practice as symbiotic processes, competitive funding strategies, and the integral role of research students. The entire commentary is located in a celebratory context of 20 years of Australian nursing education in the university sector, a context not without controversy. We give consideration to the best way ahead for the future of nursing research programs and hope our ideas spark further sharing of experiences.

  9. Research results of the Optimiturve research program in 1991

    International Nuclear Information System (INIS)

    Alakangas, E.

    1992-01-01

    Optimiturve research program is one of the energy research programs funded by the Ministry of Trade and Industry of Finland. The main target of the program is double the annual hectare yield of peat dried by solar radiation to decrease the peat production costs, to speed up the circulation of capital invested to peat production with the aid of a new production method developed in this research, and hence improve the price competitivity of peat. The targets of the research program are expected to be completed by improving the drying of peat, the efficiency of the peat production machinery, and by developing peat production techniques. The program was started in 1988, and the targets are to be fulfilled up to year 1993. The research program is carried out in cooperation with universities, research organizations and peat producers. This publication consists of the results of the ongoing projects in the Optimiturve research program in 1991. The aim, the contents and the main results of the 18 projects are presented. At the end of this publication there is a list of the reports published in Reports series

  10. Nebraska Prostate Cancer Research Program

    Science.gov (United States)

    2014-07-01

    chemotherapy can cure the disease, in many cases it will spread and kill the patient. Better basic scientific understanding of this disease is needed...Dixon Patent Development at UNEMED 10:30 T. Wasmoen Vaccine Research/Development at Intervet/Schering- Plough July 19 UNMC...cytokines and has been shown to inhibit the secretion of TNF-α by activated macrophages and thereby reduce the tumor killing activity of macrophages

  11. Environmental research program: FY 1987, annual report

    International Nuclear Information System (INIS)

    1988-03-01

    This multidisciplinary research program includes fundamental and applied research in physics, chemistry, engineering, and biology, as well as research on the development of advanced methods of measurement and analysis. The Program's Annual Report contains summaries of research performed during FY 1987 in the areas of atmospheric aerosols, flue gas chemistry, combustion, membrane bioenergetics, and analytical chemistry. The main research interests of the Atmospheric Aerosol Research group concern the chemical and physical processes that occur in haze, clouds, and fogs. For their studies, the group is developing novel analytical and research methods for characterizing aerosol species. Aerosol research is performed in the laboratory and in the field. Studies of smoke emissions from fires and their possible effects on climatic change, especially as related to nuclear winter, are an example of the collaboration between the Atmospheric Aerosol Research and Combustion Research Groups

  12. Environmental research program: FY 1987, annual report

    Energy Technology Data Exchange (ETDEWEB)

    1988-03-01

    This multidisciplinary research program includes fundamental and applied research in physics, chemistry, engineering, and biology, as well as research on the development of advanced methods of measurement and analysis. The Program's Annual Report contains summaries of research performed during FY 1987 in the areas of atmospheric aerosols, flue gas chemistry, combustion, membrane bioenergetics, and analytical chemistry. The main research interests of the Atmospheric Aerosol Research group concern the chemical and physical processes that occur in haze, clouds, and fogs. For their studies, the group is developing novel analytical and research methods for characterizing aerosol species. Aerosol research is performed in the laboratory and in the field. Studies of smoke emissions from fires and their possible effects on climatic change, especially as related to nuclear winter, are an example of the collaboration between the Atmospheric Aerosol Research and Combustion Research Groups.

  13. Genetic variability of broodstocks of restocking programs in Brazil

    Directory of Open Access Journals (Sweden)

    Nelson Lopera-Barrero

    2015-09-01

    Full Text Available Objective. The aim of this study was evaluate the genetic diversity of the following broodstocks: piapara (Leporinus elongatus, dourado (Salminus brasiliensis, jundiá (Rhamdia quelen and cachara (Pseudoplatystoma fasciatum already useful for restocking programs in the Paranapanema, Iguaçu and Paraná Brazilian Rivers. Materials and methods. Samples from the caudal fin of 122 fish were analyzed. DNA was extracted by NaCl protocol. PCR products were separated by a horizontal agarose gel electrophoresis. The fragments were visualized by staining with ethidium bromide. Results. The amplification of 25 primers generated different fragments in studied species that allowed characterizing 440 fragments of 100-2900 bp. High percentage of polymorphic fragments (66.67 to 86.29, Shannon index (0.365 to 0.486 and genetic diversity of Nei (0.248 to 0.331 were detected. Conclusions. The level of genetic variability in the broodstocks was adequate for allowing their use in restocking programs in the studied Rivers. However, periodical monitoring studies of genetic variability in these stocks, the mating system, reproductive system and general management must be made to guarantee the preservation of wild populations.

  14. Genetic Programming for Sea Level Predictions in an Island Environment

    Directory of Open Access Journals (Sweden)

    M.A. Ghorbani

    2010-03-01

    Full Text Available Accurate predictions of sea-level are important for geodetic applications, navigation, coastal, industrial and tourist activities. In the current work, the Genetic Programming (GP and artificial neural networks (ANNs were applied to forecast half-daily and daily sea-level variations from 12 hours to 5 days ahead. The measurements at the Cocos (Keeling Islands in the Indian Ocean were used for training and testing of the employed artificial intelligence techniques. A comparison was performed of the predictions from the GP model and the ANN simulations. Based on the comparison outcomes, it was found that the Genetic Programming approach can be successfully employed in forecasting of sea level variations.

  15. Multigene Genetic Programming for Estimation of Elastic Modulus of Concrete

    Directory of Open Access Journals (Sweden)

    Alireza Mohammadi Bayazidi

    2014-01-01

    Full Text Available This paper presents a new multigene genetic programming (MGGP approach for estimation of elastic modulus of concrete. The MGGP technique models the elastic modulus behavior by integrating the capabilities of standard genetic programming and classical regression. The main aim is to derive precise relationships between the tangent elastic moduli of normal and high strength concrete and the corresponding compressive strength values. Another important contribution of this study is to develop a generalized prediction model for the elastic moduli of both normal and high strength concrete. Numerous concrete compressive strength test results are obtained from the literature to develop the models. A comprehensive comparative study is conducted to verify the performance of the models. The proposed models perform superior to the existing traditional models, as well as those derived using other powerful soft computing tools.

  16. Genetic Contributions to Clinical Pain and Analgesia: Avoiding Pitfalls in Genetic Research

    Science.gov (United States)

    Kim, Hyungsuk; Clark, David; Dionne, Raymond A.

    2010-01-01

    Understanding the genetic basis of human variations in pain is critical to elucidating the molecular basis of pain sensitivity, variable responses to analgesic drugs, and, ultimately, to individualized treatment of pain and improved public health. With the help of recently accumulated knowledge and advanced technologies, pain researchers hope to gain insight into genetic mechanisms of pain and eventually apply this knowledge to pain treatment. Perspective We critically reviewed the published literature to examine the strength of evidence supporting genetic influences on clinical and human experimental pain. Based on this evidence and the experience of false associations that have occurred in other related disciplines, we provide recommendations for avoiding pitfalls in pain genetic research. PMID:19559388

  17. Review of fusion research program: historical summary and program projections

    Energy Technology Data Exchange (ETDEWEB)

    Murphy, E.S.

    1976-09-01

    This report provides a brief review of the history and current status of fusion research in the United States. It also describes the Federally funded program aimed at the development of fusion reactors for electric power generation.

  18. Summer Undergraduate Research Program: Environmental studies

    Energy Technology Data Exchange (ETDEWEB)

    McMillan, J. [ed.

    1994-12-31

    The purpose of the summer undergraduate internship program for research in environmental studies is to provide an opportunity for well-qualified students to undertake an original research project as an apprentice to an active research scientist in basic environmental research. The students are offered research topics at the Medical University in the scientific areas of pharmacology and toxicology, epidemiology and risk assessment, environmental microbiology, and marine sciences. Students are also afforded the opportunity to work with faculty at the University of Charleston, SC, on projects with an environmental theme. Ten well-qualified students from colleges and universities throughout the eastern United States were accepted into the program.

  19. Genetic diversity of tambaqui broodstocks in stock enhancement programs

    Directory of Open Access Journals (Sweden)

    Americo Moraes Neto

    2017-06-01

    Full Text Available Natural populations of tambaqui (Colossoma macropomum have significantly decreased in recent decades especially due to human extraction activities. So that the environmental impact may be reduced, the restocking of fish and increase in fish production are enhanced. Genetic evaluations using molecular markers are essential for this purpose. Current study evaluates the genetic variability of two tambaqui broodstocks used in restocking programs. Sixty-five samples (33 samples from broodstock A and 32 samples from broodstock B were collected. DNA was extracted from caudal fin samples, with the amplification of four microsatellite loci: Cm1A11 (EU685307 Cm1C8 (EU685308 Cm1F4 (EU685311 and Cm1H8 (EU685315. Fourteen alleles in the stock of broodstock A were produced, five alleles for Cm1A11 locus (230, 255, 260, 270 and 276 bp, three alleles Cm1C8 (239, 260, and 273 bp, two alleles Cm1F4 (211 and 245 bp, four alleles for Cm1H8 (275, 290, 320 and 331 bp and two unique alleles were found for Cm1A11 loci (alleles 270 and 276 bp and Cm1H8 (alleles 275 and 331 bp. In broodstock B, ten alleles were produced, the same alleles of the first stock except for alleles 270 and 276 bp in Cm1A11 locus and 275 and 331 bp in Cm1H8 locus. Broodstock A revealed low frequency alleles in Cm1A11 loci, Cm1C8, Cm1F4 and Cm1H8, whereas broodstock B had no locus with low allelic frequency. Loci Cm1A11, Cm1C8 and Cm1H8 exhibited significant deficit of heterozygotes in both broodstocks, revealing changes in Hardy-Weinberg equilibrium. Genetic diversity between stocks was 0.1120, whilst genetic similarity was 0.894, with FST rate = 0.05, and Nm = 3.93, indicating gene flow between the two broodstocks. Results show that broodstocks are genetically closely related, with no great genetic variability. Strategies such as a previous genetic analysis of breeding with its marking, use of a large Ne crossing between the most genetically divergent specimens, and the introduction of new

  20. GAS INDUSTRY GROUNDWATER RESEARCH PROGRAM

    Energy Technology Data Exchange (ETDEWEB)

    James A. Sorensen; John R. Gallagher; Steven B. Hawthorne; Ted R. Aulich

    2000-10-01

    The objective of the research described in this report was to provide data and insights that will enable the natural gas industry to (1) significantly improve the assessment of subsurface glycol-related contamination at sites where it is known or suspected to have occurred and (2) make scientifically valid decisions concerning the management and/or remediation of that contamination. The described research was focused on subsurface transport and fate issues related to triethylene glycol (TEG), diethylene glycol (DEG), and ethylene glycol (EG). TEG and DEG were selected for examination because they are used in a vast majority of gas dehydration units, and EG was chosen because it is currently under regulatory scrutiny as a drinking water pollutant. Because benzene, toluene, ethylbenzene, and xylenes (collectively referred to as BTEX) compounds are often very closely associated with glycols used in dehydration processes, the research necessarily included assessing cocontaminant effects on waste mobility and biodegradation. BTEX hydrocarbons are relatively water-soluble and, because of their toxicity, are of regulatory concern. Although numerous studies have investigated the fate of BTEX, and significant evidence exists to indicate the potential biodegradability of BTEX in both aerobic and anaerobic environments (Kazumi and others, 1997; Krumholz and others, 1996; Lovely and others, 1995; Gibson and Subramanian, 1984), relatively few investigations have convincingly demonstrated in situ biodegradation of these hydrocarbons (Gieg and others, 1999), and less work has been done on investigating the fate of BTEX species in combination with miscible glycols. To achieve the research objectives, laboratory studies were conducted to (1) characterize glycol related dehydration wastes, with emphasis on identification and quantitation of coconstituent organics associated with TEG and EG wastes obtained from dehydration units located in the United States and Canada, (2) evaluate

  1. University Research Consortium annual review meeting program

    International Nuclear Information System (INIS)

    1996-07-01

    This brochure presents the program for the first annual review meeting of the University Research Consortium (URC) of the Idaho National Engineering Laboratory (INEL). INEL is a multiprogram laboratory with a distinctive role in applied engineering. It also conducts basic science research and development, and complex facility operations. The URC program consists of a portfolio of research projects funded by INEL and conducted at universities in the United States. In this program, summaries and participant lists for each project are presented as received from the principal investigators

  2. Environmental research program. 1992 annual report

    Energy Technology Data Exchange (ETDEWEB)

    1993-07-01

    The objective of the Environmental Research Program is to contribute to the understanding of the formation, mitigation, transport, transformation, and ecological effects of energy-related pollutants on the environment. The program is multidisciplinary and includes fundamental and applied research in chemistry, physics, biology, engineering, and ecology. The program undertakes research and development in efficient and environmentally benign combustion, pollution abatement and destruction, and novel methods of detection and analysis of criteria and non-criteria pollutants. This diverse group investigates combustion, atmospheric processes, flue-gas chemistry, and ecological systems.

  3. University Research Consortium annual review meeting program

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-07-01

    This brochure presents the program for the first annual review meeting of the University Research Consortium (URC) of the Idaho National Engineering Laboratory (INEL). INEL is a multiprogram laboratory with a distinctive role in applied engineering. It also conducts basic science research and development, and complex facility operations. The URC program consists of a portfolio of research projects funded by INEL and conducted at universities in the United States. In this program, summaries and participant lists for each project are presented as received from the principal investigators.

  4. Natural and accelerated bioremediation research program plan

    International Nuclear Information System (INIS)

    1995-09-01

    This draft plan describes a ten-year program to develop the scientific understanding needed to harness and develop natural and enhanced biogeochemical processes to bioremediate contaminated soils, sediments and groundwater at DOE facilities. The Office of Health and Environmental Research (OHER) developed this program plan, with advice and assistance from DOE's Office of Environmental Management (EM). The program builds on OHER's tradition of sponsoring fundamental research in the life and environmental sciences and was motivated by OHER's and Office of Energy Research's (OER's) commitment to supporting DOE's environmental management mission and the belief that bioremediation is an important part of the solution to DOE's environmental problems

  5. Human Research Program Integrated Research Plan. Revision A January 2009

    Science.gov (United States)

    2009-01-01

    The Integrated Research Plan (IRP) describes the portfolio of Human Research Program (HRP) research and technology tasks. The IRP is the HRP strategic and tactical plan for research necessary to meet HRP requirements. The need to produce an IRP is established in HRP-47052, Human Research Program - Program Plan, and is under configuration management control of the Human Research Program Control Board (HRPCB). Crew health and performance is critical to successful human exploration beyond low Earth orbit. The Human Research Program (HRP) is essential to enabling extended periods of space exploration because it provides knowledge and tools to mitigate risks to human health and performance. Risks include physiological and behavioral effects from radiation and hypogravity environments, as well as unique challenges in medical support, human factors, and behavioral or psychological factors. The Human Research Program (HRP) delivers human health and performance countermeasures, knowledge, technologies and tools to enable safe, reliable, and productive human space exploration. Without HRP results, NASA will face unknown and unacceptable risks for mission success and post-mission crew health. This Integrated Research Plan (IRP) describes HRP s approach and research activities that are intended to address the needs of human space exploration and serve HRP customers and how they are integrated to provide a risk mitigation tool. The scope of the IRP is limited to the activities that can be conducted with the resources available to the HRP; it does not contain activities that would be performed if additional resources were available. The timescale of human space exploration is envisioned to take many decades. The IRP illustrates the program s research plan through the timescale of early lunar missions of extended duration.

  6. 1974 review of the research program

    International Nuclear Information System (INIS)

    1975-01-01

    The role of the Research Program in Controlled Thermonuclear Research, the activities that are contained within the Research Program, and summaries of the reports prepared by the study groups that analyzed the six activity areas that make up the Research Program are described. The recommendations by an ''Overview Panel'' are given. The recommendations are based on an analysis of the individual study group reports, consultations with CTR staff and field scientists, and on independent review of CTR program plans and needs. In some cases the recommendations of the Overview Panel are identical with study group recommendations and in other cases they are not. Some recommendations by the Overview Panel take into account factors and information that go beyond that available to the study groups. The five-year budget needed to accomplish the recommended Research Program is discussed. The Overview Panel chose to normalize its budget recommendations to the actual FY 1975 Research Program budget, reflecting the fact that this is already determined. The budgets for subsequent years are then based on this starting point. The complete reports prepared by the six study groups are given. Each report is based on an analysis of the needs as dictated by the Magnetic Confinement Systems and Development and Technology Program Plans. (U.S.)

  7. Undergraduate Research Program Between SCU and SOFIA

    Science.gov (United States)

    Kulas, Kristin Rose; Andersson, B.-G.

    2018-06-01

    We present results on an undergraduate research program run in collaboration between Santa Clara University (SCU), a predominately undergraduate liberal arts college and the SOFIA Science Center/USRA. We have started a synergistic program between SCU and SOFIA (located at NASA Ames) where the students are able to be fully immersed in astronomical research; from helping to write telescope observing proposal; to observing at a world-class telescope; to reducing and analyzing the data that they acquired and ultimately to presenting/publishing their findings. A recently awarded NSF collaborative grant will allow us to execute and expand this program over the next several years. In this poster we present some of our students research and their success after the program. In addition, we discuss how a small university can actively collaborate with a large government-funded program like SOFIA, funded by NASA.

  8. Small business innovation research program solicitation

    Science.gov (United States)

    1994-01-01

    The National Aeronautics and Space Administration invites eligible small business concerns to submit Phase 1 proposals for its 1994 Small Business Innovation Research (SBIR) Program, which is described in this twelfth annual NASA SBIR Program Solicitation. The 1994 solicitation period for Phase 1 proposals begins April 4, 1994 and ends June 15, 1994. Eligible firms with research or research and development capabilities (R/R&D) in any of the listed topic and subtopic areas are encouraged to participate. Through SBIR, NASA seeks innovative concepts addressing the program needs described in the SBIR solicitation subtopics and offering commercial application potential. This document contains program background information, outlines eligibility requirements for SBIR participants, describes the three SBIR program phases, and provides the information qualified offerors need to prepare and submit responsive proposals.

  9. Decontamination Systems Information and Research Program

    International Nuclear Information System (INIS)

    Berg, M.; Sack, W.A.; Gabr, M.

    1994-01-01

    The Decontamination Systems Information and Research Program at West Virginia University consists of research and development associated with hazardous waste remediation problems at the Department of Energy complex and elsewhere. This program seeks to facilitate expedited development and implementation of solutions to the nation's hazardous waste clean-up efforts. By a unique combination of university research and private technology development efforts, new paths toward implementing technology and speeding clean-ups are achievable. Mechanisms include aggressive industrial tie-ins to academic development programs, expedited support of small business technology development efforts, enhanced linkages to existing DOE programs, and facilitated access to hazardous waste sites. The program topically falls into an information component, which includes knowledge acquisition, technology evaluation and outreach activities and an R and D component, which develops and implements new and improved technologies. Projects began in February 1993 due to initiation of a Cooperative Agreement between West Virginia University and the Department of Energy

  10. The role of social networking sites in medical genetics research.

    Science.gov (United States)

    Reaves, Allison Cook; Bianchi, Diana W

    2013-05-01

    Social networking sites (SNS) have potential value in the field of medical genetics as a means of research subject recruitment and source of data. This article examines the current role of SNS in medical genetics research and potential applications for these sites in future studies. Facebook is the primary SNS considered, given the prevalence of its use in the United States and role in a small but growing number of studies. To date, utilization of SNS in medical genetics research has been primarily limited to three studies that recruited subjects from populations of Facebook users [McGuire et al. (2009); Am J Bioeth 9: 3-10; Janvier et al. (2012); Pediatrics 130: 293-298; Leighton et al. (2012); Public Health Genomics 15: 11-21]. These studies and a number of other medical and public health studies that have used Facebook as a context for recruiting research subjects are discussed. Approaches for Facebook-based subject recruitment are identified, including paid Facebook advertising, snowball sampling, targeted searching and posting. The use of these methods in medical genetics research has the potential to facilitate cost-effective research on both large, heterogeneous populations and small, hard-to-access sub-populations. Copyright © 2013 Wiley Periodicals, Inc.

  11. Applying genetic algorithms for programming manufactoring cell tasks

    Directory of Open Access Journals (Sweden)

    Efredy Delgado

    2005-05-01

    Full Text Available This work was aimed for developing computational intelligence for scheduling a manufacturing cell's tasks, based manily on genetic algorithms. The manufacturing cell was modelled as beign a production-line; the makespan was calculated by using heuristics adapted from several libraries for genetic algorithms computed in C++ builder. Several problems dealing with small, medium and large list of jobs and machinery were resolved. The results were compared with other heuristics. The approach developed here would seem to be promising for future research concerning scheduling manufacturing cell tasks involving mixed batches.

  12. Psychiatric genetic research at the National Institute of Mental Health

    Energy Technology Data Exchange (ETDEWEB)

    Berg, K.; Mullican, C.; Maestri, N. [NIMH/NIH, Rockville, MD (United States)] [and others

    1994-12-15

    For some time it has been known through the results of family, twin, and adoption studies that hereditary appears to play a significant casual role in many mental disorders, including schizophrenia, bipolar disorder, and other mood disorders, Alzheimer`s Disease, panic disorder, obsessive compulsive disorder, autism, dyslexia, and Tourette`s syndrome. The precise patterns of inheritance of these complex disorders have not been determined, nor have the relevant genes been localized or cloned. Because the genetics are complex and because there is also clearly an environmental contribution to behavior, we expect the analysis of the genetics of mental illness to be arduous and not quickly resolved. There are several compelling reasons to continue to focus our attention on uncovering the genetic factors for severe mental illness. Prominent among these are the implications for better treatment of mental disorders. The National Institute of Mental Health supports a wide range of studies on psychiatric genetic research. 16 refs.

  13. Multitechnology and supporting research programs

    International Nuclear Information System (INIS)

    Anon.

    1978-01-01

    This section includes research efforts that provide information applicable to several presently operating technologies as well as those being investigated for the future. In these technologies the nature of the environmental problem is equally applicable to any one technology; e.g., thermal and chemical pollution of water due to operation of steam electric plants, whether nuclear, fossil fuel, or gas fired; or, the statistical design needed for differentiating a general background of industrial pollution from the contributions, if any, arising from operation of an energy facility. The two main groups of projects reported include biomathematical methods for the analysis of natural systems and the quantitative ecology of impact evaluation; and aquatic ecological studies including the effects of water quality alterations on fish behavior; the ecological effects of combined aquatic stressors; the effects of energy systems effluents on coastal ecosystems; the bioavailability of energy effluent materials in coastal ecosystems; the marine chemistry of energy-generated pollutants; and methods for in situ measurement of pollutants

  14. Sea Turtle Research Program Summary Report

    National Research Council Canada - National Science Library

    1997-01-01

    The USACE Sea Turtle Research Program (STRP) was conducted to minimize the risk to sea turtle populations in channels along the southeast Atlantic region of the United States from hopper-dredging activities...

  15. Structural Metadata Research in the Ears Program

    National Research Council Canada - National Science Library

    Liu, Yang; Shriberg, Elizabeth; Stolcke, Andreas; Peskin, Barbara; Ang, Jeremy; Hillard, Dustin; Ostendorf, Mari; Tomalin, Marcus; Woodland, Phil; Harper, Mary

    2005-01-01

    Both human and automatic processing of speech require recognition of more than just words. In this paper we provide a brief overview of research on structural metadata extraction in the DARPA EARS rich transcription program...

  16. Progeria Research Foundation Diagnostic Testing Program

    Science.gov (United States)

    ... Share the DVD Meet the Kids in the Movie Bring LATS to the classroom! Close News/Events ... this could severely affect their research results and interpretation. Through the PRF Diagnostics Program, each cell line ...

  17. Environmental Research Division's Data Access Program (ERDDAP)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — ERDDAP (the Environmental Research Division's Data Access Program) is a data server that gives you a simple, consistent way to download subsets of scientific...

  18. Research Awards: Canadian Partnerships Program Deadline: 12 ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Jean-Claude Dumais

    2012-09-12

    Sep 12, 2012 ... IDRC's Canadian Partnerships (CP) Program offers a Research ... For this, they may consider quantitative and qualitative methods, case studies, ... What types of processes do Canadian organizations use to learn about their ...

  19. NASA Small Business Innovation Research program

    Science.gov (United States)

    Johnson, Harry W.

    1985-01-01

    NASA activities in the framework of the 11-agency federal Small Business Innovation Research program are outlined in tables and graphs and briefly characterized. Statistics on the program are given; the technical topics covered are listed; and the procedures involved in evaluating applications for support are discussed. A number of typical defects in proposals are indicated, and recommendations for avoiding them are provided.

  20. Research Review: Laboratory Student Magazine Programs.

    Science.gov (United States)

    Wheeler, Tom

    1994-01-01

    Explores research on student-produced magazines at journalism schools, including the nature of various programs and curricular structures, ethical considerations, and the role of faculty advisors. Addresses collateral sources that provide practical and philosophical foundations for the establishment and conduct of magazine production programs.…

  1. AECL programs in basic physics research

    International Nuclear Information System (INIS)

    Bartholomew, G.A.; Dolling, G.; Harvey, M.; Milton, J.C.D.

    1982-02-01

    This report describes the CRNL program of research into the basic properties of atomic nuclei and condensed matter (liquids and solids). Brief descriptions are given of some of the current experimental programs done principally at the NRU reactor and MP tandem accelerator, the associated theoretical studies, and some highlights of past achievements

  2. New energy technologies. Research program proposition

    International Nuclear Information System (INIS)

    2005-02-01

    This document presents the most promising program propositions of research and development and the public financing needed for their realization. The concerned technologies are: the hydrogen and the fuel cell PAN-H, the separation and the storage of the CO 2 , the photovoltaic solar electricity, the PREBAT program of the building energy recovery and the bio-energies. (A.L.B.)

  3. Training program attracts work and health researchers

    DEFF Research Database (Denmark)

    Skakon, Janne

    2007-01-01

    Each year in Canada, the costs of disability arising from work-related causes – including workers’ compensation and health-care costs – exceed $6.7 billion. Despite the significant financial and social impacts of worker injury and illness, only a small fraction of Canadian researchers are dedicated...... to examining work disability prevention issues. An innovative program that attracts international students, the Work Disability Prevention Canadian Institutes of Health Research (CIHR) Strategic Training Program, aims to build research capacity in young researchers and to create a strong network that examines...

  4. Research and Development Conference CIEE Program 1992

    Energy Technology Data Exchange (ETDEWEB)

    1992-01-01

    CIEE's second annual Research and Development Conference will introduce you to some of the results achieved to date through CIEE-sponsored multiyear research performed in three programs: Building Energy Efficiency, Air Quality Impacts of Energy Efficiency, and End-Use Resource Planning. Results from scoping studies, Director's discretionary research, and exploratory research will also be featured in this report.

  5. African Americans' opinions about human-genetics research.

    Science.gov (United States)

    Achter, Paul; Parrott, Roxanne; Silk, Kami

    2004-03-01

    Research on attitudes toward genetics and medicine registers skepticism among minority communities, but the reasons for this skepticism are not well known. In the past, studies linked mistrust of the medical system to historical ethics violations involving minority groups and to suspicions about ideological premise and political intent. To assess public knowledge, attitudes, and behavior regarding human-genetics research, we surveyed 858 Americans onsite in four community settings or online in a geographically nonspecific manner. Compared to participants as a whole, African Americans were significantly more likely to believe that clinical trials might be dangerous and that the federal government knowingly conducted unethical research, including studies in which risky vaccines were administered to prison populations. However, African Americans were also significantly more likely to believe that the federal government worked to prevent environmental exposure to toxicants harmful to people with genetic vulnerabilities. Our data suggest that most Americans trust government to act ethically in sponsoring and conducting research, including genetics research, but that African Americans are particularly likely to see government as powerfully protective in some settings yet selectively disingenuous in others.

  6. Programs of the Office of Energy Research

    International Nuclear Information System (INIS)

    1985-07-01

    The purpose of this research has been to support the energy technology development programs by providing insight into fundamental science and associated phenomena and developing new or advanced concepts and techniques. Today, this responsibility rests with the Office of Energy Research (ER), DOE, whose present programs have their origins in pioneering energy-related research which was initiated nearly 40 years ago. The Director, Office of Energy Research, also acts as the chief scientist and scientific advisor to the Secretary of Energy for the entire spectrum of energy research and development (R and D) programs of the Department. ER programs include several thousand individual projects and hundreds of laboratories, universities, and other research facilities throughout the United States. The current organization of ER is shown. The budgets for the various ER programs for the last two fiscal years are shown. In the following pages, each of these programs and activities are described briefly for the information of the scientific community and the public at large

  7. Research Ethics with Undergraduates in Summer Research Training Programs

    Science.gov (United States)

    Cheung, I.; Yalcin, K.

    2016-02-01

    Many undergraduate research training programs incorporate research ethics into their programs and some are required. Engaging students in conversations around challenging topics such as conflict of interest, cultural and gender biases, what is science and what is normative science can difficult in newly formed student cohorts. In addition, discussing topics with more distant impacts such as science and policy, intellectual property and authorship, can be difficult for students in their first research experience that have more immediate concerns about plagiarism, data manipulation, and the student/faculty relationship. Oregon State University's Research Experience for Undergraduates (REU) in Ocean Sciences: From Estuaries to the Deep Sea as one model for incorporating a research ethics component into summer undergraduate research training programs. Weaved into the 10-week REU program, undergraduate interns participate in a series of conversations and a faculty mentor panel focused on research ethics. Topics discussed are in a framework for sharing myths, knowledge and personal experiences on issues in research with ethical implications. The series follows guidelines and case studies outlined from the text, On Being A Scientist: Responsible Conduct In Research Committee on Science, Engineering, and Public Policy, National Academy of Sciences.

  8. Programs of the Office of Energy Research

    International Nuclear Information System (INIS)

    1992-09-01

    The programs of the Office of Energy Research provide basic science support for energy technologies as well as advancing understanding in general science and training future scientists. Energy Research provides insights into fundamental science and associated phenomena and develops new or advanced concepts and techniques. Research of this type has been supported by the Department of Energy and its predecessors for over 40 years and includes research in the natural and physical sciences, including high energy and nuclear physics; magnetic fusion energy; biological and environmental research; and basic energy sciences research in the materials, chemical, and applied mathematical sciences, engineering and geosciences, and energy biosciences. These basic research programs help build the science and technology base that underpins energy development by Government and industry

  9. Health, safety and environmental research program

    International Nuclear Information System (INIS)

    Dinner, P.J.

    1983-01-01

    This report outlines the Health, Safety and Environmental Research Program being undertaken by the CFFTP. The Program objectives, relationship to other CFFTP programs, implementation plans and expected outputs are stated. Opportunities to build upon the knowledge and experience gained in safely managing tritium in the CANDU program, by addressing generic questions pertinent to tritium safety for fusion facilities, are identified. These opportunities exist across a broad spectrum of issues covering the anticipated behaviour of tritium in fusion facilities, the surrounding environment and in man

  10. Regulatory research program for 1987/88

    International Nuclear Information System (INIS)

    1987-01-01

    The regulatory research program of Canada's Atomic Energy Control Board (AECB) is intended to augment the AECB's research program beyond the capability of in-house resources. The overall objective of the research program is to produce pertinent and independent information that will assist the Board and its staff in making correct, timely and credible decisions on regulating nuclear energy. The program covers the following areas: the safety of nuclear facilities, radioactive waste management, health physics, physical security, and the development of regulatory processes. Sixty-seven projects are planned for 1987/88; as well, there are some projects held in reserve in case funding becomes available. This information bulletin contains a list of the projects with a brief description of each

  11. Minority International Research Training Program: Global Collaboration in Nursing Research.

    Science.gov (United States)

    McElmurry, Beverly J.; Misner, Susan J.; Buseh, Aaron G.

    2003-01-01

    The Minority International Research Training Program pairs minority nursing students with faculty mentors at international sites for short-term research. A total of 26 undergraduate, 22 graduate, and 6 postdoctoral students have participated. Challenges include recruitment, orientation, and preparation of students; identification and preparation…

  12. Army Medical Research and Materiel Command Resident Research Associateship Program

    Science.gov (United States)

    2018-05-01

    Unlimited 13. SUPPLEMENTARY NOTES 14. ABSTRACT During this reporting period, the NRC promoted research opportunities at AMRMC institutes through a... productivity of these Associates is listed in the technical report. 15. SUBJECT TERMS- Associateship program, post-doc, awards 16. SECURITY CLASSIFICATION OF...following activities in support of the subject contract: Outreach and Promotion The promotional schedule to advertise the NRC Research Associateship

  13. Review Genetic research, behavioural science, and child and ...

    African Journals Online (AJOL)

    We describe a number of areas of recent research that are particularly relevant to child and adolescent mental health in South Africa (antisocial behaviour, disorganised attachment and depression) that are beginning to illuminate the interactions between the behavioural and genetic domains. Discussion: We argue that we ...

  14. Increasing global participation in genetics research through DNA barcoding.

    Science.gov (United States)

    Adamowicz, Sarah J; Steinke, Dirk

    2015-12-01

    DNA barcoding--the sequencing of short, standardized DNA regions for specimen identification and species discovery--has promised to facilitate rapid access to biodiversity knowledge by diverse users. Here, we advance our opinion that increased global participation in genetics research is beneficial, both to scientists and for science, and explore the premise that DNA barcoding can help to democratize participation in genetics research. We examine publication patterns (2003-2014) in the DNA barcoding literature and compare trends with those in the broader, related domain of genomics. While genomics is the older and much larger field, the number of nations contributing to the published literature is similar between disciplines. Meanwhile, DNA barcoding exhibits a higher pace of growth in the number of publications as well as greater evenness among nations in their proportional contribution to total authorships. This exploration revealed DNA barcoding to be a highly international discipline, with growing participation by researchers in especially biodiverse nations. We briefly consider several of the challenges that may hinder further participation in genetics research, including access to training and molecular facilities as well as policy relating to the movement of genetic resources.

  15. Provenance research: investigation of genetic diversity associated with geography

    Science.gov (United States)

    Robert Z. Callaham

    1963-01-01

    Provenance in forestry refers to the population of trees growing at n particular place of origin. Provenance research defines the genetic and environmental components of phenotypic variation associated with geographic source. Information on provenance is important in assuring sources of seed to give well-adapted, productive trees and in directing breeding of...

  16. Research and Applications of Shop Scheduling Based on Genetic Algorithms

    Directory of Open Access Journals (Sweden)

    Hang ZHAO

    Full Text Available ABSTRACT Shop Scheduling is an important factor affecting the efficiency of production, efficient scheduling method and a research and application for optimization technology play an important role for manufacturing enterprises to improve production efficiency, reduce production costs and many other aspects. Existing studies have shown that improved genetic algorithm has solved the limitations that existed in the genetic algorithm, the objective function is able to meet customers' needs for shop scheduling, and the future research should focus on the combination of genetic algorithm with other optimized algorithms. In this paper, in order to overcome the shortcomings of early convergence of genetic algorithm and resolve local minimization problem in search process,aiming at mixed flow shop scheduling problem, an improved cyclic search genetic algorithm is put forward, and chromosome coding method and corresponding operation are given.The operation has the nature of inheriting the optimal individual ofthe previous generation and is able to avoid the emergence of local minimum, and cyclic and crossover operation and mutation operation can enhance the diversity of the population and then quickly get the optimal individual, and the effectiveness of the algorithm is validated. Experimental results show that the improved algorithm can well avoid the emergency of local minimum and is rapid in convergence.

  17. NRC/AMRMC Resident Research Associateship Program

    Science.gov (United States)

    2018-05-01

    conducted the following activities in support of the subject contract: Outreach and Promotion The promotional schedule to advertise the NRC Research...Approved for Public Release; Distribution Unlimited 13. SUPPLEMENTARY NOTES 14. ABSTRACT During this reporting period, the NRC promoted research...Associateship Programs included the following: 1) attendance at meetings of major scientific and engineering professional societies; 2) advertising in

  18. The AECL research and development program

    International Nuclear Information System (INIS)

    Hart, R.G.; Woods, A.D.B.

    1980-02-01

    The research and development program of the Atomic Energy of Canada Research Company is briefly described. Goals and objectives are emphasized, some recent highlights are given and the importance of technology transfer is discussed. A short representative bibliography is included. (auth)

  19. Program of research 1988-89

    International Nuclear Information System (INIS)

    1988-08-01

    From 1 July 1988, the research activities of ANSTO have reorganised into five programs: advanced materials; applications of nuclear physics; environmental science; applications of radioisotopes and radiation; biomedicine and health. This structure not only groups the main research activities but also identifies the underpinning of ANSTO's commercial activities. This document describes the projects to be undertaken in the 1988-89 financial year. Each project in a particular program area is defined in terms of background, objective, recent work and achievements, work planned, resources and the project manager is identified. Research is also undertaken in areas of the operational activities of the organisation and these also are detailed

  20. Research waste management program - An action proposal

    International Nuclear Information System (INIS)

    Costa Ramos, A.; Esposito, I.

    1997-01-01

    The Brazilian Nuclear Energy Commission planned prepared and established a Research Waste Management Program, started in 1996, in order to map, to analyze and to solve the common problems in the research field. The specific study done included a large number of academic institutions. The procedures, results and operational methodology used by the Team linked to the Program, in one of the research institutions studied where corrective actions were implemented to avoid unnecessary dose to the public, will be discussed in this article. (author)

  1. Natural and accelerated bioremediation research program plan

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-09-01

    This draft plan describes a ten-year program to develop the scientific understanding needed to harness and develop natural and enhanced biogeochemical processes to bioremediate contaminated soils, sediments and groundwater at DOE facilities. The Office of Health and Environmental Research (OHER) developed this program plan, with advice and assistance from DOE`s Office of Environmental Management (EM). The program builds on OHER`s tradition of sponsoring fundamental research in the life and environmental sciences and was motivated by OHER`s and Office of Energy Research`s (OER`s) commitment to supporting DOE`s environmental management mission and the belief that bioremediation is an important part of the solution to DOE`s environmental problems.

  2. Defense Coastal/Estuarine Research Program (DCERP)

    Science.gov (United States)

    2007-09-19

    activities, splash points and Landing Craft Air Cushion (LCAC) operations) and non-military Base activities (e.g., sewage treatment , storm water runoff and...We will measure the metabolism of benthic microalgae, the water column, eelgrass, and any dominant macroalgae by developing series of photosynthesis...activities (storm water control and sewage treatment ). Defense Coastal/Estuarine Research Program (DCERP) Research Plan DCERP Research Plan 32 September 19

  3. Base Program on Energy Related Research

    Energy Technology Data Exchange (ETDEWEB)

    Western Research Institute

    2008-06-30

    The main objective of the Base Research Program was to conduct both fundamental and applied research that will assist industry in developing, deploying, and commercializing efficient, nonpolluting fossil energy technologies that can compete effectively in meeting the energy requirements of the Nation. In that regard, tasks proposed under the WRI research areas were aligned with DOE objectives of secure and reliable energy; clean power generation; development of hydrogen resources; energy efficiency and development of innovative fuels from low and no-cost sources. The goal of the Base Research Program was to develop innovative technology solutions that will: (1) Increase the production of United States energy resources--coal, natural gas, oil, and renewable energy resources; (2) Enhance the competitiveness of United States energy technologies in international markets and assist in technology transfer; (3) Reduce the nation's dependence on foreign energy supplies and strengthen both the United States and regional economies; and (4) Minimize environmental impacts of energy production and utilization. This report summarizes the accomplishments of the overall Base Program. This document represents a stand-alone Final Report for the entire Program. It should be noted that an interim report describing the Program achievements was prepared in 2003 covering the progress made under various tasks completed during the first five years of this Program.

  4. ANSTO - program of research 1991-1992

    International Nuclear Information System (INIS)

    1991-01-01

    The direction and priorities of the Australian Nuclear Science and Technology Organisation (ANSTO) research program are outlined. During the period under review. Many of the initiatives of previous years come to fruition, adding significant strength and dimension to the Organisation's research capabilities. The advent of Australian Supercomputing Technology, a joint venture between Fujitsu Australia and ANSTO, will enable the grand challenges of computational science to underpin Ansto research generally but specifically in environmental science. The development of the accelerator mass spectrometry facilities on the tandem accelerator supported new initiatives in environmental research and management. The National Medical Cyclotron opens a new era in radiopharmaceutical research and development. Finally, the recently commissioned hot isostatic press provides a unique national resource for the development of new ceramics and their applications. The direction and priorities of Ansto's research program are determined through a combination of external and internal review. The Program Advisory Committees provide external evaluation against national objectives. New Committees have been formed and membership reflects the national and international nature of the ANSTO research programs. ills

  5. Review of defense display research programs

    Science.gov (United States)

    Tulis, Robert W.; Hopper, Darrel G.; Morton, David C.; Shashidhar, Ranganathan

    2001-09-01

    Display research has comprised a substantial portion of the defense investment in new technology for national security for the past 13 years. These investments have been made by the separate service departments and, especially, via several Defense Research Projects Agency (DARPA) programs, known collectively as the High Definition Systems (HDS) Program (which ended in 2001) and via the Office of the Secretary of Defense (OSD) Defense Production Act (DPA) Title III Program (efforts ended in 2000). Using input from the Army, Navy, and Air Force to focus research and identify insertion opportunities, DARPA and the Title III Program Office have made investments to develop the national technology base and manufacturing infrastructure necessary to meet the twin challenge of providing affordable displays in current systems and enabling the DoD strategy of winning future conflicts by getting more information to all participants during the battle. These completed DARPA and DPA research and infrastructure programs are reviewed. Service investments have been and are being made to transition display technology; examples are described. Display science and technology (S&T) visions are documented for each service to assist the identification of areas meriting consideration for future defense research.

  6. Stream Flow Prediction by Remote Sensing and Genetic Programming

    Science.gov (United States)

    Chang, Ni-Bin

    2009-01-01

    A genetic programming (GP)-based, nonlinear modeling structure relates soil moisture with synthetic-aperture-radar (SAR) images to present representative soil moisture estimates at the watershed scale. Surface soil moisture measurement is difficult to obtain over a large area due to a variety of soil permeability values and soil textures. Point measurements can be used on a small-scale area, but it is impossible to acquire such information effectively in large-scale watersheds. This model exhibits the capacity to assimilate SAR images and relevant geoenvironmental parameters to measure soil moisture.

  7. Small Business Innovation Research Program. Program solicitation FY 1984

    International Nuclear Information System (INIS)

    1984-01-01

    The Nuclear Regulatory Commission (NRC) invites science-based and high-technology small business firms to submit research proposals under this program solicitation entitled Small Business Innovation Research (SBIR). Firms with strong research capabilities in science or engineering in any of the following topic areas are encouraged to participate. NRC will support high-quality research proposals on important scientific or engineering problems and opportunities that could lead to significant advancement in the safety of nuclear operations or nuclear power plants. Objectives of the solicitation include stimulating technological innovation in the private sector, strengthening the role of small business in meeting Federal research and development needs, increasing the commercial application of NRC-supported research results, and improving the return on investment from Federally funded research for economic and social benefits to the Nation

  8. Invited review: Genetic and genomic mouse models for livestock research

    Directory of Open Access Journals (Sweden)

    D. Arends

    2018-02-01

    Full Text Available Knowledge about the function and functioning of single or multiple interacting genes is of the utmost significance for understanding the organism as a whole and for accurate livestock improvement through genomic selection. This includes, but is not limited to, understanding the ontogenetic and environmentally driven regulation of gene action contributing to simple and complex traits. Genetically modified mice, in which the functions of single genes are annotated; mice with reduced genetic complexity; and simplified structured populations are tools to gain fundamental knowledge of inheritance patterns and whole system genetics and genomics. In this review, we briefly describe existing mouse resources and discuss their value for fundamental and applied research in livestock.

  9. Space Life Sciences Research and Education Program

    Science.gov (United States)

    Coats, Alfred C.

    2001-01-01

    Since 1969, the Universities Space Research Association (USRA), a private, nonprofit corporation, has worked closely with the National Aeronautics and Space Administration (NASA) to advance space science and technology and to promote education in those areas. USRA's Division of Space Life Sciences (DSLS) has been NASA's life sciences research partner for the past 18 years. For the last six years, our Cooperative Agreement NCC9-41 for the 'Space Life Sciences Research and Education Program' has stimulated and assisted life sciences research and education at NASA's Johnson Space Center (JSC) - both at the Center and in collaboration with outside academic institutions. To accomplish our objectives, the DSLS has facilitated extramural research, developed and managed educational programs, recruited and employed visiting and staff scientists, and managed scientific meetings.

  10. NRC/AMRMC Resident Research Associateship Program

    Science.gov (United States)

    2018-05-01

    2- 0010 Report Period: 02/06/2012-02/28/2018 4/11/2018, 12:17 PM During the reporting period, the National Academies of Sciences, Engineering , and...to advertise the NRC Research Associateship Programs included the following: 1) attendance at meetings of major scientific and engineering ...professional societies; 2) advertising in programs and career centers for these and other professional society meetings; 3) direct mailing and emailing of

  11. Teacher Research Programs = Increased Student Achievement

    Science.gov (United States)

    Dubner, J.

    2011-12-01

    Columbia University's Summer Research Program for Science Teachers (SRP), founded in 1990, is one of the largest, best known university professional development programs for science teachers in the U.S. For eight weeks in each of two consecutive summers, teachers participate as a member of a research team, led by a member of Columbia University's research faculty. In addition to the laboratory experience, all teachers meet weekly during the summer for a series of pedagogical activities to assist them in transferring the experience to their classrooms. The primary goal of the program is to provide K-12 science teachers with opportunities to work at the cutting edge of science and engineering, and thus to revitalize their teaching and help them to appreciate the use of inquiry-based methods in their classroom instruction. The secondary goals of the program are to give the pre-college teacher the ability to guide their students toward careers in science and engineering, to develop new teaching strategies, and to foster long-term scholarly collaborations. The last is especially important as it leads to a model of the teacher as active in science yet committed to the pre-college classroom. Since its inception, SRP has focused on an objective assessment of the program's impact on attitudes and instructional practices of participating teachers, on the performance of these teachers in their mentors' laboratories, and most importantly, on the impact of their participation in the program has on student interest and performance in science. Our research resulted in a paper published in the journal Science. SRP also facilitates a multi-site survey-based evaluation of other teacher research programs around the country. The author will present the findings of both studies.

  12. Applied Information Systems Research Program Workshop

    Science.gov (United States)

    1991-01-01

    The first Applied Information Systems Research Program (AISRP) Workshop provided the impetus for several groups involved in information systems to review current activities. The objectives of the workshop included: (1) to provide an open forum for interaction and discussion of information systems; (2) to promote understanding by initiating a dialogue with the intended benefactors of the program, the scientific user community, and discuss options for improving their support; (3) create an advocacy in having science users and investigators of the program meet together and establish the basis for direction and growth; and (4) support the future of the program by building collaborations and interaction to encourage an investigator working group approach for conducting the program.

  13. Collaborative applied research programs at AITF

    Energy Technology Data Exchange (ETDEWEB)

    Chow, Ross [Alberta Innovates Technology Futures (Canada)

    2011-07-01

    Alberta Innovates Technology Futures (AITF) is a 600 employee company created in 2010 and owned by the Alberta government; offices are located in Edmonton, Devon, Vegreville and Calgary. The purpose of this document is to present the services provided by AITF. The company provides technical support and advisory services as well as commercialization support, they provide the link between the concept stage and the commercialization stage. AITF proposes collaborative programs which can be consortia made up of a series of projects on general industry issues or joint industry projects which focus on a specific issue. During this presentation, a joint industry project, the fuels and lubricants exchange program, was presented along with several consortia such as the carbonate research program, the materials and reliability in oil sands program, and the AACI program. This presentation highlighted the work carried out by AITF to meet the needs of their clients.

  14. Programming peptidomimetic syntheses by translating genetic codes designed de novo.

    Science.gov (United States)

    Forster, Anthony C; Tan, Zhongping; Nalam, Madhavi N L; Lin, Hening; Qu, Hui; Cornish, Virginia W; Blacklow, Stephen C

    2003-05-27

    Although the universal genetic code exhibits only minor variations in nature, Francis Crick proposed in 1955 that "the adaptor hypothesis allows one to construct, in theory, codes of bewildering variety." The existing code has been expanded to enable incorporation of a variety of unnatural amino acids at one or two nonadjacent sites within a protein by using nonsense or frameshift suppressor aminoacyl-tRNAs (aa-tRNAs) as adaptors. However, the suppressor strategy is inherently limited by compatibility with only a small subset of codons, by the ways such codons can be combined, and by variation in the efficiency of incorporation. Here, by preventing competing reactions with aa-tRNA synthetases, aa-tRNAs, and release factors during translation and by using nonsuppressor aa-tRNA substrates, we realize a potentially generalizable approach for template-encoded polymer synthesis that unmasks the substantially broader versatility of the core translation apparatus as a catalyst. We show that several adjacent, arbitrarily chosen sense codons can be completely reassigned to various unnatural amino acids according to de novo genetic codes by translating mRNAs into specific peptide analog polymers (peptidomimetics). Unnatural aa-tRNA substrates do not uniformly function as well as natural substrates, revealing important recognition elements for the translation apparatus. Genetic programming of peptidomimetic synthesis should facilitate mechanistic studies of translation and may ultimately enable the directed evolution of small molecules with desirable catalytic or pharmacological properties.

  15. Experimental control of a fluidic pinball using genetic programming

    Science.gov (United States)

    Raibaudo, Cedric; Zhong, Peng; Noack, Bernd R.; Martinuzzi, Robert J.

    2017-11-01

    The wake stabilization of a triangular cluster of three rotating cylinders was investigated in the present study. Experiments were performed at Reynolds number Re 6000, and compared with URANS-2D simulations at same flow conditions. 2D2C PIV measurements and constant temperature anemometry were used to characterize the flow without and with actuation. Open-loop actuation was first considered for the identification of particular control strategies. Machine learning control was also implemented for the experimental study. Linear genetic programming has been used for the optimization of open-loop parameters and closed-loop controllers. Considering a cost function J based on the fluctuations of the velocity measured by the hot-wire sensor, significant performances were achieved using the machine learning approach. The present work is supported by the senior author's (R. J. Martinuzzi) NSERC discovery Grant. C. Raibaudo acknowledges the financial support of the University of Calgary Eyes-High PDF program.

  16. Overview of NRC PRA research program

    International Nuclear Information System (INIS)

    Cunningham, M.A.; Drouin, M.T.; Ramey-Smith, A.M.; VanderMolen, M.T.

    1997-01-01

    The NRC's research program in probabilistic risk analysis includes a set of closely-related elements, from basic research to regulatory applications. The elements of this program are as follows: (1) Development and demonstration of methods and advanced models and tools for use by the NRC staff and others performing risk assessments; (2) Support to agency staff on risk analysis and statistics issues; (3) Reviews of risk assessments submitted by licensees in support of regulatory applications, including the IPEs and IPEEEs. Each of these elements is discussed in the paper, providing highlights of work within an element, and, where appropriate, describing important support and feedback mechanisms among elements

  17. Maryland controlled fusion research program. Volume I

    International Nuclear Information System (INIS)

    1985-01-01

    This renewal proposal describes the University of Maryland research program on Magnetic Fusion Energy for a three-year period beginning January 1, 1986. This program consists of five tasks: (I) Plasma Theory; (II) Electron Cyclotron Emission Diagnostics for Mirror Machines; (III) Electron Cyclotron Emission Diagnostics on TFTR; (IV) Atomic Physics; and (V) Magnetic Field Measurement by Ion Beams. The four separate tasks of continuing research (Tasks I to IV) and the new experimental task (Task V) are described in detail. The task descriptions contain estimated budgets for CY 86, 87, and 88

  18. Environmental Research Program. 1994 annual report

    Energy Technology Data Exchange (ETDEWEB)

    Brown, N.J.

    1995-04-01

    The objective of the Environmental Research Program is to enhance the understanding of, and mitigate the effects of pollutants on health, ecological systems, global and regional climate, and air quality. The program is multi-disciplinary and includes fundamental research and development in efficient and environmentally-benign combustion, pollutant abatement and destruction, and novel methods of detection and analysis of criteria and non-criteria pollutants. This diverse group conducts investigations in combustion, atmospheric and marine processes, flue-gas chemistry, and ecological systems.

  19. Research and Technology Development for Genetic Improvement of Switchgrass

    Energy Technology Data Exchange (ETDEWEB)

    Kausch, Albert [Univ. of Rhode Island, Kingston, RI (United States); Rhodes, Richard [Univ. of Rhode Island, Kingston, RI (United States)

    2017-05-02

    This research adds to the understanding of switchgrass genetics and the increasing of biomass relevant to production of bioenergy. Switchgrass, Panicum virgatum L., and its related species are well known as potential bioenergy crops since the early 1990s. There are global economic, political, US national security and environmental pressures to increase renewable biofuel production and utilization to offset gasoline and diesel fuel use and climate change, especially in the liquid fuel transportation sector. To realize the potential of bioenergy crops, rapid genetic improvement of the most promising perennial grass feedstocks, such as switchgrass, are anticipated by current genomics, association genetics, marker assisted breeding, hybrid plant development, advanced tissue culture, conventional genetics and other approaches to increase yield, processability, and regional adaptation. The technical effectiveness and economic feasibility of the methods or techniques investigated are demonstrated by several publications, presentations and patents produced as an outcome and deliverable of this research. This project is of a broad benefit to the public not only through the dissemination of this information but also to the development of new methods which will be applied to future bioenergy crop improvement as well as other crops.

  20. Surrogate receptivity to participation in critical illness genetic research: aligning research oversight and stakeholder concerns.

    Science.gov (United States)

    Freeman, Bradley D; Butler, Kevin; Bolcic-Jankovic, Dragana; Clarridge, Brian R; Kennedy, Carie R; LeBlanc, Jessica; Chandros Hull, Sara

    2015-04-01

    Collection of genetic biospecimens as part of critical illness investigations is increasingly commonplace. Oversight bodies vary in restrictions imposed on genetic research, introducing inconsistencies in study design, potential for sampling bias, and the possibility of being overly prohibitive of this type of research altogether. We undertook this study to better understand whether restrictions on genetic data collection beyond those governing research on cognitively intact subjects reflect the concerns of surrogates for critically ill patients. We analyzed survey data collected from 1,176 patients in nonurgent settings and 437 surrogates representing critically ill adults. Attitudes pertaining to genetic data (familiarity, perceptions, interest in participation, concerns) and demographic information were examined using univariate and multivariate techniques. We explored differences among respondents who were receptive (1,333) and nonreceptive (280) to genetic sample collection. Whereas factors positively associated with receptivity to research participation were "complete trust" in health-care providers (OR, 2.091; 95% CI, 1.544-2.833), upper income strata (OR, 2.319; 95% CI, 1.308-4.114), viewing genetic research "very positively" (OR, 3.524; 95% CI, 2.122-5.852), and expressing "no worry at all" regarding disclosure of results (OR, 2.505; 95% CI, 1.436-4.369), black race was negatively associated with research participation (OR, 0.410; 95% CI, 0.288-0.585). We could detect no difference in receptivity to genetic sample collection comparing ambulatory patients and surrogates (OR, 0.738; 95% CI, 0.511-1.066). Expressing trust in health-care providers and viewing genetic research favorably were associated with increased willingness for study enrollment, while concern regarding breach of confidentiality and black race had the opposite effect. Study setting had no bearing on willingness to participate.

  1. 83-inch cyclotron research program. Final report

    International Nuclear Information System (INIS)

    Parkinson, W.C.

    1983-07-01

    In June of 1960 the US Atomic Energy Commission authorized the construction of a modern variable energy cyclotron facility at The University of Michigan to be used for research in nuclear spectroscopy. The Legislature of the State of Michigan made available funds for construction of a building to house the 83-inch cyclotron and auxiliary equipment as well as the University's remodeled 42-inch cyclotron. The research program centered around the 83-inch cyclotron was funded by the AEC and its successors, the Energy Research and Development Administration (ERDA) and the Department of Energy (DOE), from September 1964 through March 1977. The program represented a continuation of the research effort using the 42-inch cyclotron facility which had been supported continuously by the AEC since February 1950. This final report to DOE briefly describes the research facility, the research program, and highlights the principal accomplishments of the effort. It begins with a historical note to place this effort within the context of nuclear physics research in the Department of Physics of the University of Michigan

  2. Towards Merging Binary Integer Programming Techniques with Genetic Algorithms

    Directory of Open Access Journals (Sweden)

    Reza Zamani

    2017-01-01

    Full Text Available This paper presents a framework based on merging a binary integer programming technique with a genetic algorithm. The framework uses both lower and upper bounds to make the employed mathematical formulation of a problem as tight as possible. For problems whose optimal solutions cannot be obtained, precision is traded with speed through substituting the integrality constrains in a binary integer program with a penalty. In this way, instead of constraining a variable u with binary restriction, u is considered as real number between 0 and 1, with the penalty of Mu(1-u, in which M is a large number. Values not near to the boundary extremes of 0 and 1 make the component of Mu(1-u large and are expected to be avoided implicitly. The nonbinary values are then converted to priorities, and a genetic algorithm can use these priorities to fill its initial pool for producing feasible solutions. The presented framework can be applied to many combinatorial optimization problems. Here, a procedure based on this framework has been applied to a scheduling problem, and the results of computational experiments have been discussed, emphasizing the knowledge generated and inefficiencies to be circumvented with this framework in future.

  3. Advancing research on loyalty programs: a future research agenda

    OpenAIRE

    Breugelmans, Els; Bijmolt, Tammo H. A.; Zhang, Jie; Basso, Leonardo J.; Dorotic, Matilda; Kopalle, Praveen; Minnema, Alec; Mijnlieff, Willem Jan; Wünderlich, Nancy V.

    2015-01-01

    This is the authors’ accepted and refereed manuscript to the article Despite the growing literature on loyalty program (LP) research, many questions remain underexplored. Driven by advancements in information technology, marketing analytics, and consumer interface platforms (e.g., mobile devices), there have been many recent developments in LP practices around the world. They impose new challenges and create exciting opportunities for future LP research. The main objective of this paper is...

  4. Geothermal Reservoir Technology Research Program: Abstracts of selected research projects

    Energy Technology Data Exchange (ETDEWEB)

    Reed, M.J. (ed.)

    1993-03-01

    Research projects are described in the following areas: geothermal exploration, mapping reservoir properties and reservoir monitoring, and well testing, simulation, and predicting reservoir performance. The objectives, technical approach, and project status of each project are presented. The background, research results, and future plans for each project are discussed. The names, addresses, and telephone and telefax numbers are given for the DOE program manager and the principal investigators. (MHR)

  5. Safety research programs sponsored by Office of Nuclear Regulatory Research

    International Nuclear Information System (INIS)

    Weiss, A.J.; Azarm, A.; Baum, J.W.

    1989-07-01

    This progress report describes current activities and technical progress in the programs at Brookhaven National Laboratory sponsored by the Division of Regulatory Applications, Division of Engineering, Division of Safety Issue Resolution, and Division of Systems Research of the US Nuclear Regulatory Commission, Office of Nuclear Regulatory Research following the reorganization in July 1988. The previous reports have covered the period October 1, 1976 through September 30, 1988

  6. IRSN research programs concerning reactor safety

    International Nuclear Information System (INIS)

    Bardelay, J.

    2005-01-01

    This paper is made up of 3 parts. The first part briefly presents the missions of IRSN (French research institute on nuclear safety), the second part reviews the research works currently led by IRSN in the following fields : -) the assessment of safety computer codes, -) thermohydraulics, -) reactor ageing, -) reactivity accidents, -) loss of coolant, -) reactor pool dewatering, -) core meltdown, -) vapor explosion, and -) fission product release. In the third part, IRSN is shown to give a major importance to experimental programs led on research or test reactors for collecting valid data because of the complexity of the physical processes that are involved. IRSN plans to develop a research program concerning the safety of high or very high temperature reactors. (A.C.)

  7. Program of research - 1990-1991

    International Nuclear Information System (INIS)

    1991-01-01

    The 1990-1991 Program of Research reflects the fundamental changes within the Australian Nuclear Science and Technology Organization (ANSTO) over the past three years as it has oriented itself towards being a more commercially driven organization, an organization responding to market demands and pressures. From July 1, 1990 several key projects have been linked together in the new Industrial Technology Program. The Program encompasses projects that have real potential to earn revenue for ANSTO and make measurable improvements in efficiency and productivity for Australian companies. The Isotope Technology project is researching and transferring to industry radioisotope technology for tracing the effectiveness of plant processes, the movement of materials within blast furnaces and leakages and outages in plant pipework. The two important newcomers are the Quality Technology Centre and the Safety and Reliability group. Details about project leaders, project titles and objectives are provided. ills

  8. ANSTO program of research 1989-1990

    International Nuclear Information System (INIS)

    1989-09-01

    The 1989-1990 Program of Research of the Australian Nuclear Science and Technology Organization identifies the diversity of the organisation's current activities and the role of nuclear science and technology in achieving national goals. Major program areas continue to be biomedicine and health, advanced materials, applications of nuclear physics, environmental science, isotope technology and nuclear technology. Each project in a particular program area is defined in terms of background, objectives recent work and achievements, work planned and resources. External advisory committees which provide advice on research priorities, are viewed as a fundamental part of the ongoing evaluation process of the organization activities in response to changing priorities in industry, government and the community it serves

  9. Successful Attendance Policies and Programs. Research Brief

    Science.gov (United States)

    Education Partnerships, Inc., 2012

    2012-01-01

    What steps can be taken to assure that High School students have the best attendance possible? It is commonly believed and well supported by research that students who attend school regularly are more successful than those who do not. The challenge for high schools is to design and implement attendance policies and programs that monitor,…

  10. Research and development program, fiscal year 1974

    Energy Technology Data Exchange (ETDEWEB)

    1972-04-01

    The biomedical program of the Laboratory of Nuclear Medicine and Radiation Biology for Fiscal Year 1974 is conducted within the scope of the following categories: Effects of Radiation of Living Organisms; Molecular and Cellular Radiobiology; Land and Fresh Water Environmental Sciences; Radiological and Health Physics and Instrumentation; and Nuclear Medical Research. (ACR)

  11. Criteria for deciding about forestry research programs

    Science.gov (United States)

    Robert Z. Callaham

    1981-01-01

    In early 1979, the Forest Service, U.S. Department of Agriculture, was required to decide several significant issues affecting its future research program. These decisions were in response to requirements of the Forest and Rangeland Renewable Resources Planning Act of 1974 (RPA). The decisions required information that was not either available or assembled. Most...

  12. Portuguese research program on nuclear fusion

    International Nuclear Information System (INIS)

    Varandas, C.A.F.; Cabral, J.A.C.; Manso, M.E.

    1994-01-01

    The Portuguese research program on nuclear fusion is presented. The experimental activity associated with the tokamak ISTTOK as well as the work carried out in the frame of international collaboration are summarized. The main technological features of ISTTOK are described along with studies on microwave reflectometry. Future plans are briefly described

  13. AECL research programs in systems chemistry

    International Nuclear Information System (INIS)

    Lister, D.H.; Pathania, R.S.

    1984-05-01

    Research programs in Systems Chemistry are aimed at preserving the integrity of the many working systems in CANDU reactors and at minimizing chemistry-induced problems such as radiation field growth or fouling of surfaces. The topics of main concern are the chemistry and corrosion of steam generators, for it is in this general area that the potential for serious problems is very real

  14. A research program in empirical computer science

    Science.gov (United States)

    Knight, J. C.

    1991-01-01

    During the grant reporting period our primary activities have been to begin preparation for the establishment of a research program in experimental computer science. The focus of research in this program will be safety-critical systems. Many questions that arise in the effort to improve software dependability can only be addressed empirically. For example, there is no way to predict the performance of the various proposed approaches to building fault-tolerant software. Performance models, though valuable, are parameterized and cannot be used to make quantitative predictions without experimental determination of underlying distributions. In the past, experimentation has been able to shed some light on the practical benefits and limitations of software fault tolerance. It is common, also, for experimentation to reveal new questions or new aspects of problems that were previously unknown. A good example is the Consistent Comparison Problem that was revealed by experimentation and subsequently studied in depth. The result was a clear understanding of a previously unknown problem with software fault tolerance. The purpose of a research program in empirical computer science is to perform controlled experiments in the area of real-time, embedded control systems. The goal of the various experiments will be to determine better approaches to the construction of the software for computing systems that have to be relied upon. As such it will validate research concepts from other sources, provide new research results, and facilitate the transition of research results from concepts to practical procedures that can be applied with low risk to NASA flight projects. The target of experimentation will be the production software development activities undertaken by any organization prepared to contribute to the research program. Experimental goals, procedures, data analysis and result reporting will be performed for the most part by the University of Virginia.

  15. Nuclear Plant Aging Research (NPAR) program plan

    International Nuclear Information System (INIS)

    1991-06-01

    A comprehensive Nuclear Plant Aging Research (NPAR) Program was implemented by the US NRC office of Nuclear Regulatory Research in 1985 to identify and resolve technical safety issues related to the aging of systems, structures, and components in operating nuclear power plants. This is Revision 2 to the Nuclear Plant Aging Research Program Plant. This planes defines the goals of the program the current status of research, and summarizes utilization of the research results in the regulatory process. The plan also describes major milestones and schedules for coordinating research within the agency and with organizations and institutions outside the agency, both domestic and foreign. Currently the NPAR Program comprises seven major areas: (1) hardware-oriented engineering research involving components and structures; (2) system-oriented aging interaction studies; (3) development of technical bases for license renewal rulemaking; (4) determining risk significance of aging phenomena; (5) development of technical bases for resolving generic safety issues; (6) recommendations for field inspection and maintenance addressing aging concerns; (7) and residual lifetime evaluations of major LWR components and structures. The NPAR technical database comprises approximately 100 NUREG/CR reports by June 1991, plus numerous published papers and proceedings that offer regulators and industry important insights to aging characteristics and aging management of safety-related equipment. Regulatory applications include revisions to and development of regulatory guides and technical specifications; support to resolve generic safety issues; development of codes and standards; evaluation of diagnostic techniques; (e.g., for cables and valves); and technical support for development of the license renewal rule. 80 refs., 25 figs., 10 tabs

  16. The Precision Medicine Initiative's All of Us Research Program: an agenda for research on its ethical, legal, and social issues.

    Science.gov (United States)

    Sankar, Pamela L; Parker, Lisa S

    2017-07-01

    The Precision Medicine Initiative (PMI) is an innovative approach to developing a new model of health care that takes into account individual differences in people's genes, environments, and lifestyles. A cornerstone of the initiative is the PMI All of Us Research Program (formerly known as PMI-Cohort Program) which will create a cohort of 1 million volunteers who will contribute their health data and biospecimens to a centralized national database to support precision medicine research. The PMI All of US Research Program is the largest longitudinal study in the history of the United States. The designers of the Program anticipated and addressed some of the ethical, legal, and social issues (ELSI) associated with the initiative. To date, however, there is no plan to call for research regarding ELSI associated with the Program-PMI All of Us program. Based on analysis of National Institutes of Health (NIH) funding announcements for the PMI All of Us program, we have identified three ELSI themes: cohort diversity and health disparities, participant engagement, and privacy and security. We review All of Us Research Program plans to address these issues and then identify additional ELSI within each domain that warrant ongoing investigation as the All of Us Research Program develops. We conclude that PMI's All of Us Research Program represents a significant opportunity and obligation to identify, analyze, and respond to ELSI, and we call on the PMI to initiate a research program capable of taking on these challenges.Genet Med advance online publication 01 December 2016.

  17. DOE (Department of Energy) Epidemiologic Research Program: Selected bibliography

    Energy Technology Data Exchange (ETDEWEB)

    1991-01-01

    The objective of the Department of Energy (DOE) Epidemiologic Research Program is to determine the human health effects resulting from the generation and use of energy, and from the operation of DOE facilities. The program has been divided into seven general areas of activity: the Radiation Effects Research Foundation (RERF) which supports studies of survivors of the atomic weapons in Hiroshima and Nagasaki, mortality and morbidity studies of DOE workers, studies on internally deposited alpha emitters, medical/histologic studies, studies on the genetic aspects of radiation damage, community health surveillance studies, and the development of computational techniques and of databases to make the results as widely useful as possible. Excluding the extensive literature from the RERF, the program has produced 380 publications in scientific journals, contributing significantly to improving the understanding of the health effects of ionizing radiation exposure. In addition, a large number of public presentations were made and are documented elsewhere in published proceedings or in books. The purpose of this bibliograhpy is to present a guide to the research results obtained by scientists supported by the program. The bibliography, which includes doctoral theses, is classified by national laboratory and by year. Multi-authored studies are indicated only once, according to the main supporting laboratory.

  18. The Mouse House: A brief history of the ORNL mouse-genetics program, 1947–2009

    Energy Technology Data Exchange (ETDEWEB)

    Russell, Liane B.

    2013-10-01

    The large mouse genetics program at the Oak Ridge National Lab is often re-membered chiefly for the germ-cell mutation-rate data it generated and their uses in estimating the risk of heritable radiation damage. In fact, it soon became a multi-faceted research effort that, over a period of almost 60 years, generated a wealth of information in the areas of mammalian mutagenesis, basic genetics (later enriched by molecular techniques), cytogenetics, reproductive biology, biochemistry of germ cells, and teratology. Research in the area of germ-cell mutagenesis explored the important physical and biological factors that affect the frequency and nature of induced mutations and made several unexpected discoveries, such as the major importance of the perigametic interval (the zygote stage) for the origin of spontaneous mutations and for the sensitivity to induced genetic change. Of practical value was the discovery that ethylnitrosourea was a supermutagen for point mutations, making high-efficiency mutagenesis in the mouse feasible worldwide. Teratogenesis findings resulted in recommendations still generally accepted in radiological practice. Studies supporting the mutagenesis research added whole bodies of information about mammalian germ-cell development and about molecular targets in germ cells. The early decision to not merely count but propagate genetic variants of all sorts made possible further discoveries, such as the Y-Chromosome s importance in mammalian sex determination and the identification of rare X-autosome translocations, which, in turn, led to the formulation of the single-active-X hypothesis and provided tools for studies of functional mosaicism for autosomal genes, male sterility, and chromosome-pairing mechanism. Extensive genetic and then molecular analyses of large numbers of induced specific-locus mutants resulted in fine-structure physical and correlated functional mapping of significant portions of the mouse genome and constituted a valuable

  19. The Mouse House: a brief history of the ORNL mouse-genetics program, 1947-2009.

    Science.gov (United States)

    Russell, Liane B

    2013-01-01

    The large mouse genetics program at the Oak Ridge National Laboratory (ORNL) is often remembered chiefly for the germ-cell mutation-rate data it generated and their uses in estimating the risk of heritable radiation damage. In fact, it soon became a multi-faceted research effort that, over a period of almost 60 years, generated a wealth of information in the areas of mammalian mutagenesis, basic genetics (later enriched by molecular techniques), cytogenetics, reproductive biology, biochemistry of germ cells, and teratology. Research in the area of germ-cell mutagenesis explored the important physical and biological factors that affect the frequency and nature of induced mutations and made several unexpected discoveries, such as the major importance of the perigametic interval (the zygote stage) for the origin of spontaneous mutations and for the sensitivity to induced genetic change. Of practical value was the discovery that ethylnitrosourea was a supermutagen for point mutations, making high-efficiency mutagenesis in the mouse feasible worldwide. Teratogenesis findings resulted in recommendations still generally accepted in radiological practice. Studies supporting the mutagenesis research added whole bodies of information about mammalian germ-cell development and about molecular targets in germ cells. The early decision to not merely count but propagate genetic variants of all sorts made possible further discoveries, such as the Y-chromosome's importance in mammalian sex determination and the identification of rare X-autosome translocations, which, in turn, led to the formulation of the single-active-X hypothesis and provided tools for studies of functional mosaicism for autosomal genes, male sterility, and chromosome-pairing mechanism. Extensive genetic and then molecular analyses of large numbers of induced specific-locus mutants resulted in fine-structure physical and correlated functional mapping of significant portions of the mouse genome and constituted a

  20. Federal Geothermal Research Program Update, FY 2000

    Energy Technology Data Exchange (ETDEWEB)

    Renner, Joel Lawrence

    2001-08-01

    The Department of Energy's Geothermal Program serves two broad purposes: 1) to assist industry in overcoming near-term barriers by conducting cost-shared research and field verification that allows geothermal energy to compete in today's aggressive energy markets; and 2) to undertake fundamental research with potentially large economic payoffs. The four categories of work used to distinguish the research activities of the Geothermal Program during FY 2000 reflect the main components of real-world geothermal projects. These categories form the main sections of the project descriptions in this Research Update. Exploration Technology research focuses on developing instruments and techniques to discover hidden hydrothermal systems and to explore the deep portions of known systems. Research in geophysical and geochemical methods is expected to yield increased knowledge of hidden geothermal systems. Reservoir Technology research combines laboratory and analytical investigations with equipment development and field testing to establish practical tools for resource development and management for both hydrothermal reservoirs and enhanced geothermal systems. Research in various reservoir analysis techniques is generating a wide range of information that facilitates development of improved reservoir management tools. Drilling Technology focuses on developing improved, economic drilling and completion technology for geothermal wells. Ongoing research to avert lost circulation episodes in geothermal drilling is yielding positive results. Conversion Technology research focuses on reducing costs and improving binary conversion cycle efficiency, to permit greater use of the more abundant moderate-temperature geothermal resource, and on the development of materials that will improve the operating characteristics of many types of geothermal energy equipment. Increased output and improved performance of binary cycles will result from investigations in heat cycle research.

  1. DOE [Department of Energy] Epidemiologic Research Program

    International Nuclear Information System (INIS)

    1990-01-01

    The objective of the Department of Energy (DOE) Epidemiologic Research Program is to determine the human health effects resulting from the generation and use of energy, and of the operation of DOE facilities. The program is divided into seven general areas of activity; the Radiation Effects Research Foundation (RERF) which supports studies of survivors of the atomic weapons in Hiroshima and Nagasaki, mortality and morbidity studies of DOE workers, studies on internally deposited alpha emitters, medical/histologic studies, studies on the aspects of radiation damage, community health surveillance studies, and the development of computational techniques and of databases to make the results as widely useful as possible. Excluding the extensive literature from the RERF, the program has produced 340 publications in scientific journals, contributing significantly to improving the understanding of the health effects of ionizing radiation exposure. In addition, a large number of public presentations were made and are documented elsewhere in published proceedings or in books. The purpose of this bibliography is to present a guide to the research results obtained by scientists supported by the program. The bibliography, which includes doctoral theses, is classified by laboratory and by year and also summarizes the results from individual authors by journal

  2. DOE (Department of Energy) Epidemiologic Research Program

    Energy Technology Data Exchange (ETDEWEB)

    1990-01-01

    The objective of the Department of Energy (DOE) Epidemiologic Research Program is to determine the human health effects resulting from the generation and use of energy, and of the operation of DOE facilities. The program is divided into seven general areas of activity; the Radiation Effects Research Foundation (RERF) which supports studies of survivors of the atomic weapons in Hiroshima and Nagasaki, mortality and morbidity studies of DOE workers, studies on internally deposited alpha emitters, medical/histologic studies, studies on the aspects of radiation damage, community health surveillance studies, and the development of computational techniques and of databases to make the results as widely useful as possible. Excluding the extensive literature from the RERF, the program has produced 340 publications in scientific journals, contributing significantly to improving the understanding of the health effects of ionizing radiation exposure. In addition, a large number of public presentations were made and are documented elsewhere in published proceedings or in books. The purpose of this bibliography is to present a guide to the research results obtained by scientists supported by the program. The bibliography, which includes doctoral theses, is classified by laboratory and by year and also summarizes the results from individual authors by journal.

  3. Small business innovation research: Program solicitation

    Science.gov (United States)

    1989-01-01

    This, the seventh annual SBIR solicitation by NASA, describes the program, identifies eligibility requirements, outlines the required proposal format and content, states proposal preparation and submission requirements, describes the proposal evaluation and award selection process, and provides other information to assist those interested in participating in NASA's SBIR program. It also identifies the Technical Topics and Subtopics in which SBIR Phase 1 proposals are solicited in 1989. These Topics and Subtopics cover a broad range of current NASA interests, but do not necessarily include all areas in which NASA plans or currently conducts research. High-risk high pay-off innovations are desired.

  4. Forecasting tourist arrivals to balearic islands using genetic programming

    Directory of Open Access Journals (Sweden)

    Rosselló-Nadal, Jaume

    2007-01-01

    Full Text Available Traditionally, univariate time-series models have largely dominated forecasting for international tourism demand. In this paper, the ability of a Genetic Program (GP to predict monthly tourist arrivals from UK and Germany to Balearic Islands (Spain is explored. GP has already been employed satisfactorily in different scientific areas, including economics. The technique shows different advantages regarding to other forecasting methods. Firstly, it does not assume a priori a rigid functional form of the model. Secondly, it is more robust and easy-to-use than other non-parametric methods. Finally, it provides explicitly a mathematical equation which allows a simple ad hoc interpretation of the results. Comparing the performance of the proposed technique against other method commonly used in tourism forecasting (no-change model, Moving Average and ARIMA, the empirical results reveal that GP can be a valuable tool in this field.

  5. A Comparison of Genetic Programming Variants for Hyper-Heuristics

    Energy Technology Data Exchange (ETDEWEB)

    Harris, Sean [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2015-03-01

    Modern society is faced with ever more complex problems, many of which can be formulated as generate-and-test optimization problems. General-purpose optimization algorithms are not well suited for real-world scenarios where many instances of the same problem class need to be repeatedly and efficiently solved, such as routing vehicles over highways with constantly changing traffic flows, because they are not targeted to a particular scenario. Hyper-heuristics automate the design of algorithms to create a custom algorithm for a particular scenario. Hyper-heuristics typically employ Genetic Programming (GP) and this project has investigated the relationship between the choice of GP and performance in Hyper-heuristics. Results are presented demonstrating the existence of problems for which there is a statistically significant performance differential between the use of different types of GP.

  6. Genetic Programming and Standardization in Water Temperature Modelling

    Directory of Open Access Journals (Sweden)

    Maritza Arganis

    2009-01-01

    Full Text Available An application of Genetic Programming (an evolutionary computational tool without and with standardization data is presented with the aim of modeling the behavior of the water temperature in a river in terms of meteorological variables that are easily measured, to explore their explanatory power and to emphasize the utility of the standardization of variables in order to reduce the effect of those with large variance. Recorded data corresponding to the water temperature behavior at the Ebro River, Spain, are used as analysis case, showing a performance improvement on the developed model when data are standardized. This improvement is reflected in a reduction of the mean square error. Finally, the models obtained in this document were applied to estimate the water temperature in 2004, in order to provide evidence about their applicability to forecasting purposes.

  7. Research program on regulatory safety research - Synthesis report 2008

    International Nuclear Information System (INIS)

    Mailaender, R

    2009-06-01

    This report for the Swiss Federal Office of Energy (SFOE) summarises the program's main points of interest, work done in the year 2008 and the results obtained. The main points of the research program, which is co-ordinated by the Swiss Federal Nuclear Safety Inspectorate ENSI, are discussed. Topics covered concern reactor safety as well as human, organisational and safety aspects. Work done in several areas concerning reactor safety and materials as well as interactions in severe accidents in light-water reactors is described. Radiation protection, the transport and disposal of radioactive wastes and safety culture are also looked at. Finally, national and international co-operation is briefly looked at and work to be done in 2009 is reviewed. The report is completed with a list of research and development projects co-ordinated by ENSI

  8. Suborbital Science Program: Dryden Flight Research Center

    Science.gov (United States)

    DelFrate, John

    2008-01-01

    This viewgraph presentation reviews the suborbital science program at NASA Dryden Flight Research Center. The Program Objectives are given in various areas: (1) Satellite Calibration and Validation (Cal/val)--Provide methods to perform the cal/val requirements for Earth Observing System satellites; (2) New Sensor Development -- Provide methods to reduce risk for new sensor concepts and algorithm development prior to committing sensors to operations; (3) Process Studies -- Facilitate the acquisition of high spatial/temporal resolution focused measurements that are required to understand small atmospheric and surface structures which generate powerful Earth system effects; and (4) Airborne Networking -- Develop disruption-tolerant networking to enable integrated multiple scale measurements of critical environmental features. Dryden supports the NASA Airborne Science Program and the nation in several elements: ER-2, G-3, DC-8, Ikhana (Predator B) & Global Hawk and Reveal. These are reviewed in detail in the presentation.

  9. Medical Research Volunteer Program (MRVP): innovative program promoting undergraduate research in the medical field.

    Science.gov (United States)

    Dagher, Michael M; Atieh, Jessica A; Soubra, Marwa K; Khoury, Samia J; Tamim, Hani; Kaafarani, Bilal R

    2016-06-06

    Most educational institutions lack a structured system that provides undergraduate students with research exposure in the medical field. The objective of this paper is to describe the structure of the Medical Research Volunteer Program (MRVP) which was established at the American University of Beirut, Lebanon, as well as to assess the success of the program. The MRVP is a program that targets undergraduate students interested in becoming involved in the medical research field early on in their academic career. It provides students with an active experience and the opportunity to learn from and support physicians, clinical researchers, basic science researchers and other health professionals. Through this program, students are assigned to researchers and become part of a research team where they observe and aid on a volunteer basis. This paper presents the MRVP's four major pillars: the students, the faculty members, the MRVP committee, and the online portal. Moreover, details of the MRVP process are provided. The success of the program was assessed by carrying out analyses using information gathered from the MRVP participants (both students and faculty). Satisfaction with the program was assessed using a set of questions rated on a Likert scale, ranging from 1 (lowest satisfaction) to 5 (highest satisfaction). A total of 211 students applied to the program with a total of 164 matches being completed. Since the beginning of the program, three students have each co-authored a publication in peer-reviewed journals with their respective faculty members. The majority of the students rated the program positively. Of the total number of students who completed the program period, 35.1 % rated the effectiveness of the program with a 5, 54.8 % rated 4, and 8.6 % rated 3. A small number of students gave lower ratings of 2 and 1 (1.1 % and 0.4 %, respectively). The MRVP is a program that provides undergraduate students with the opportunity to learn about research firsthand

  10. The National Geothermal Energy Research Program

    Science.gov (United States)

    Green, R. J.

    1974-01-01

    The continuous demand for energy and the concern for shortages of conventional energy resources have spurred the nation to consider alternate energy resources, such as geothermal. Although significant growth in the one natural steam field located in the United States has occurred, a major effort is now needed if geothermal energy, in its several forms, is to contribute to the nation's energy supplies. From the early informal efforts of an Interagency Panel for Geothermal Energy Research, a 5-year Federal program has evolved whose objective is the rapid development of a commercial industry for the utilization of geothermal resources for electric power production and other products. The Federal program seeks to evaluate the realistic potential of geothermal energy, to support the necessary research and technology needed to demonstrate the economic and environmental feasibility of the several types of geothermal resources, and to address the legal and institutional problems concerned in the stimulation and regulation of this new industry.

  11. Program for transfer research and impact studies

    Science.gov (United States)

    Rusnak, J. J.; Freeman, J. E.; Hartley, J. M.; Kottenstette, J. P.; Staskin, E. R.

    1973-01-01

    Research activities conducted under the Program for Transfer Research and Impact Studies (TRIS) during 1972 included: (1) preparation of 10,196 TSP requests for TRIS application analysis; (2) interviews with over 500 individuals concerning the technical, economic, and social impacts of NASA-generated technology; (3) preparation of 38 new technology transfer example files and 101 new transfer cases; and (4) maintenance of a technology transfer library containing more than 2,900 titles. Six different modes of technology utilization are used to illustrate the pervasiveness of the transfer and diffusion of aerospace innovations. These modes also provide a basis for distinguishing the unique characteristics of the NASA Technology Utilization Program. An examination is reported of the ways in which NASA-generated technology is contributing to beneficial social change in five major areas of human concern: health, environment, safety, transportation, and communication.

  12. The Nanotoxicology Research Program in NIOSH

    Science.gov (United States)

    Castranova, Vincent

    2009-01-01

    The National Institute for Occupational Safety and Health through its Nanotechnology Research Center has developed a Strategic Plan for Nanotechnology Safety and Health Research. This Strategic Plan identified knowledge gaps and critical issues, which must be addressed to protect the health and safety of workers producing nanoparticles as well as those incorporating nanoparticles into commercial products or using nanomaterials in novel applications. This manuscript lists the projects that comprise the Nanotoxicology Program in NIOSH and provides a brief description of the goals and accomplishments of these projects.

  13. Laboratory Directed Research and Development Program

    International Nuclear Information System (INIS)

    1994-02-01

    This report is compiled from annual reports submitted by principal investigators following the close of fiscal year 1993. This report describes the projects supported and summarizes their accomplishments. The program advances the Laboratory's core competencies, foundations, scientific capability, and permits exploration of exciting new opportunities. Reports are given from the following divisions: Accelerator and Fusion Research, Chemical Sciences, Earth Sciences, Energy and Environment, Engineering, Environment -- Health and Safety, Information and Computing Sciences, Life Sciences, Materials Sciences, Nuclear Science, Physics, and Structural Biology

  14. Collaborative Research Program on Seafood Toxins

    Science.gov (United States)

    1988-08-14

    Crystallographic Structures of Saxitoxins Cl and C2 Appendix C: Collaborative Research Program an Seafcod Toxins Progress Report on Ciguatera and Related...radioimmunoassay for PSP were also evalumted. The Hokama stick test for ciguatera toxin was also evaluated. 4. initiate Studies on the Accumulation...tco•d which caie a form of b-mnn poisoning referred to as ciguatera . The respcnsible toxins originate from ll1ular rine algae of the division

  15. Laboratory Directed Research and Development Program

    Energy Technology Data Exchange (ETDEWEB)

    Ogeka, G.J.

    1991-12-01

    Today, new ideas and opportunities, fostering the advancement of technology, are occurring at an ever-increasing rate. It, therefore, seems appropriate that a vehicle be available which fosters the development of these new ideas and technologies, promotes the early exploration and exploitation of creative and innovative concepts, and which develops new fundable'' R D projects and programs. At Brookhaven National Laboratory (BNL), one such method is through its Laboratory Directed Research and Development (LDRD) Program. This discretionary research and development tool is critical in maintaining the scientific excellence and vitality of the Laboratory. Additionally, it is a means to stimulate the scientific community, fostering new science and technology ideas, which is the major factor achieving and maintaining staff excellence, and a means to address national needs, with the overall mission of the Department of Energy (DOE) and the Brookhaven National Laboratory. The Project Summaries with their accomplishments described in this report reflect the above. Aside from leading to new fundable or promising programs and producing especially noteworthy research, they have resulted in numerous publications in various professional and scientific journals, and presentations at meetings and forums.

  16. Structural health monitoring feature design by genetic programming

    International Nuclear Information System (INIS)

    Harvey, Dustin Y; Todd, Michael D

    2014-01-01

    Structural health monitoring (SHM) systems provide real-time damage and performance information for civil, aerospace, and other high-capital or life-safety critical structures. Conventional data processing involves pre-processing and extraction of low-dimensional features from in situ time series measurements. The features are then input to a statistical pattern recognition algorithm to perform the relevant classification or regression task necessary to facilitate decisions by the SHM system. Traditional design of signal processing and feature extraction algorithms can be an expensive and time-consuming process requiring extensive system knowledge and domain expertise. Genetic programming, a heuristic program search method from evolutionary computation, was recently adapted by the authors to perform automated, data-driven design of signal processing and feature extraction algorithms for statistical pattern recognition applications. The proposed method, called Autofead, is particularly suitable to handle the challenges inherent in algorithm design for SHM problems where the manifestation of damage in structural response measurements is often unclear or unknown. Autofead mines a training database of response measurements to discover information-rich features specific to the problem at hand. This study provides experimental validation on three SHM applications including ultrasonic damage detection, bearing damage classification for rotating machinery, and vibration-based structural health monitoring. Performance comparisons with common feature choices for each problem area are provided demonstrating the versatility of Autofead to produce significant algorithm improvements on a wide range of problems. (paper)

  17. THE RESEARCH IN FISH GENETICS IN CROATIA AND FORMER YUGOSLAVIA

    Directory of Open Access Journals (Sweden)

    Tomislav Treer

    1994-03-01

    Full Text Available This is a review on fish genetics research in Croatia and former Yugoslavia, based on the analyses of all the articles published in four main journals (Ribarstvo Jugoslavije, Morsko ribarstvo, Ichthyologia and Acta Adriatica since 1945 till disintegration of Yugoslavia in 1991. Most of the papers cover the fields on cytogenetics and hybridization (24 and 13 respectively. Eight papers were on fish selection and five on population genetics. Apart from those, five papers were written by foreign authors. Two groups of researchers from the University of Sarajevo were specially active. One of them lead by B e r b e r o v i ć and S o f r a d ž i j a did extensive work in cytogenetics, analyzing the karyotypes of many fish species, some of them endemic. Another one lead by V u k o v i ć , investigated some natural hybrids and created many of them artificially, particulary among cyprinids. These results are presented in a special table. Contrary to the mountainous Bosnia where this type of research was of systematic and ecologic importance, in Croatia whwrw aquaculture was highly developed, the approach was quite different. The scientists from the University of Zagreb, H a b e k o v i ć and T u r k , studied the hybridization and selection of important cultured cyprinids. Apart from these scientific groups, many papers were published by A l - S a b t i , who later became world famous in fish cytogenetics. The works of many other authors who contributed with papers in different fields of fish genetics are also described.

  18. Empirical valence bond models for reactive potential energy surfaces: a parallel multilevel genetic program approach.

    Science.gov (United States)

    Bellucci, Michael A; Coker, David F

    2011-07-28

    We describe a new method for constructing empirical valence bond potential energy surfaces using a parallel multilevel genetic program (PMLGP). Genetic programs can be used to perform an efficient search through function space and parameter space to find the best functions and sets of parameters that fit energies obtained by ab initio electronic structure calculations. Building on the traditional genetic program approach, the PMLGP utilizes a hierarchy of genetic programming on two different levels. The lower level genetic programs are used to optimize coevolving populations in parallel while the higher level genetic program (HLGP) is used to optimize the genetic operator probabilities of the lower level genetic programs. The HLGP allows the algorithm to dynamically learn the mutation or combination of mutations that most effectively increase the fitness of the populations, causing a significant increase in the algorithm's accuracy and efficiency. The algorithm's accuracy and efficiency is tested against a standard parallel genetic program with a variety of one-dimensional test cases. Subsequently, the PMLGP is utilized to obtain an accurate empirical valence bond model for proton transfer in 3-hydroxy-gamma-pyrone in gas phase and protic solvent. © 2011 American Institute of Physics

  19. Research progress in the genetics of hyperuricaemia and gout.

    Science.gov (United States)

    Zheng, Min; Ma, Jun-wu

    2016-04-01

    Gout is one of the most common inflammatory arthritis caused by hyperuricaemia, which is affected by both genetic factors and environmental factors. Early researches show that a few of rare monogenic mutations, such as PRPS1 and HPRT1 mutations, lead to abnormal purine anabolism and then cause hyperuricaemia and gout. In recent years, genome-wide association studies (GWAS) have identified dozens of susceptibility loci and/or candidate genes associated with hyperuricemia and gout. Loss-of-function mutations in SLC2A9, SLC22A11, and SLC22A12 cause hereditary hypouricaemia, while their overexpression may increase the reabsorption of uric acid. In contrast, loss-of-function mutations in ABCG2, SLC17A1, and SLC17A3 cause urate underexcretion of renal and intestinal. These variations leading to blood uric acid excretion disorder (excess reabsorption and underexcretion) are the main genetic factors affecting hyperuicemia and gout. Moreover, to some degree, inhibins-activins growth factor system, transcription factors, cytoskeleton and gene-environment interaction can also affect the level of blood uric acid. In addition, two risk genes, RFX3 and KCNQ1, which might impair immune response and lead to functional deficiency of beta cell were recently discovered to influence hyperuiceamia and gout in Han Chinese. This paper systematically reviews genetic studies on hyperuricaemia and gout to improve our understanding of pathogenesis of hyperuricaemia and gout.

  20. Can Genetics Research Benefit Educational Interventions for All?

    Science.gov (United States)

    Asbury, Kathryn

    2015-01-01

    Pretty much everyone knows that our genes have at least something to do with how able or how high achieving we are. Some believe that we should not speak of this common knowledge, nor inquire into how genetic influence works or what it might mean. If we do not keep an open mind to the fact of genetic influence on academic achievement, however, then we cannot explore its possible implications. And if we do not consider the implications, then we cannot, as a society, harness any potential benefits or avoid possible pitfalls. So that's what this essay is about-exploring what behavioral genetics research might be able to offer to educational theory, policy, and practice. We cannot yet use biological information to make accurate predictions for all children. We do know, however, that academic achievement is heritable, which is to say that differences between individuals are influenced by differences in their DNA. If genes are part of the problem for some pupils (to take the negative spin on this), then it seems likely that studying them could be part of a solution. And that's what behavioral geneticists are trying to do-to chart and understand pathways from DNA to behavior and to identify interventions that can maximize outcomes for all. The fact is, though, that we have an awfully long way to go. © 2015 The Hastings Center.

  1. Astonishing advances in mouse genetic tools for biomedical research.

    Science.gov (United States)

    Kaczmarczyk, Lech; Jackson, Walker S

    2015-01-01

    The humble house mouse has long been a workhorse model system in biomedical research. The technology for introducing site-specific genome modifications led to Nobel Prizes for its pioneers and opened a new era of mouse genetics. However, this technology was very time-consuming and technically demanding. As a result, many investigators continued to employ easier genome manipulation methods, though resulting models can suffer from overlooked or underestimated consequences. Another breakthrough, invaluable for the molecular dissection of disease mechanisms, was the invention of high-throughput methods to measure the expression of a plethora of genes in parallel. However, the use of samples containing material from multiple cell types could obfuscate data, and thus interpretations. In this review we highlight some important issues in experimental approaches using mouse models for biomedical research. We then discuss recent technological advances in mouse genetics that are revolutionising human disease research. Mouse genomes are now easily manipulated at precise locations thanks to guided endonucleases, such as transcription activator-like effector nucleases (TALENs) or the CRISPR/Cas9 system, both also having the potential to turn the dream of human gene therapy into reality. Newly developed methods of cell type-specific isolation of transcriptomes from crude tissue homogenates, followed by detection with next generation sequencing (NGS), are vastly improving gene regulation studies. Taken together, these amazing tools simplify the creation of much more accurate mouse models of human disease, and enable the extraction of hitherto unobtainable data.

  2. Progress report on research on human genetics in Iceland

    Energy Technology Data Exchange (ETDEWEB)

    None

    1980-10-31

    Records of the Icelandic population are being used to investigate the possible inheritance of disabilities and diseases as well as other characteristics and the effect of environment on man. The progress report of research covers the period from 1977 to 1980. The investigation was begun in 1965 by the Genetical Committee of the University of Iceland and the materials used are demographic records from the year 1840 to present and various medical information. The records are being computerized and linked together to make them effective for use in hereditary studies.

  3. Research on human genetics in Iceland. Progress report

    Energy Technology Data Exchange (ETDEWEB)

    None

    1980-10-31

    Records of the Icelandic Population are being used to investigate the possible inheritance of disabilities and diseases as well as other characters and the effect of environment on man. The progress report of research covers the period 1977 to 1980. The investigation was begun in 1965 by the Genetical Committee of the University of Iceland and the materials used are demographic records from the year 1840 to present and various medical information. The records are being computerized and linked together to make them effective for use in hereditary studies.

  4. Summer High School Apprenticeship Research Program (SHARP)

    Science.gov (United States)

    1997-01-01

    objectives were consistent with the overall program goals. Modem Technology Systems, Inc., was able to meet the SHARP Apprentices, Coordinators and Mentors during their site visits to Stennis Space Center, Ames Research Center and Dryden Flight Research Center. All three Centers had very efficient programs and adhered to SHARP's general guidelines and procedures. MTSI was able to meet the apprentices from the other Centers via satellite in July during the SHARP Video-Teleconference(ViTS). The ViTS offered the apprentices and the NASA and SHARP Coordinators the opportunity to introduce themselves. The apprentices from each Center presented topical "Cutting Edge Projects". Some of the accomplishments for the 1997 SHARP Program year included: MTSI hiring apprentices from four of the nine NASA Centers, the full utilization of the EDCATS by apprentices and NASA/SHARP Coordinators, the distribution of the SHARP Apprentice College and Scholarship Directory, a reunion with former apprentices from Langley Research Center and the development of a SHARP Recruitment Poster. MTSI developed another exciting newsletter containing graphics and articles submitted by the apprentices and the SHARP Management Team.

  5. Research and development program, fiscal year 1966

    Energy Technology Data Exchange (ETDEWEB)

    1964-04-01

    The biomedical program of the Laboratory of Nuclear Medicine and Radiation Biology for FY 1966 is conducted within the scope of the following categories: Somatic Effects of Radiation; Combating Detrimental Effects of Radiation; Molecular and Cellular Level Studies; Environmental Radiation Studies; Radiological and Health Physics and Instrumentation; Chemical Toxicity; Cancer Research; and Selected Beneficial Applications. The overall objectives of the Laboratory within these areas of the Biology and Medicine program may be summarized as follows: (1) investigation of the effects of ionizing radiation on living organisms and systems of biological significance; (2) investigation of the dynamic aspects of physiological and biochemical processes in man, animals and plants and how these processes are modified by radiation and related pathological states; (3) the assessment and study of the immediate and long term consequences of the operation or detonation of nuclear devices on the fauna, and flora in man's environment and on man; (4) the development of methods of minimizing or preventing the detrimental effects of ionizing radiation; (5) research in, and development of, beneficial uses of ionizing radiation and radioactive substances in medicine and biology; (6) research in the development of new and more efficient radiation detection devices; (7) research, including field studies, as mutually agreed upon by the Commission and the University, in connection with the conduct of weapon tests and biomedical and civil effects experiments at such tests conducted at continental and overseas test sites; and (8) the conduct of training and educational activities in the biological and medical aspects of radiation and related fields.

  6. Research program plan: piping. Volume 3

    International Nuclear Information System (INIS)

    Vagins, M.; Strosnider, J.

    1985-07-01

    Regulatory issues related to piping can be divided into the three areas of pipe cracking, postulated design basis pipe breaks, and design of piping for seismic and other dynamic loads. The first two of these issues are in the domain of the Materials Engineering Branch (MEBR), while the last of the three issues is the responsibility of the Mechanical/Structural Engineering Branch. This volume of the MEBR Research Plan defines the critical aspects of the pipe cracking and postulated design basis pipe break issues and identifies those research efforts and results necessary for their resolution. In general, the objectives of the MERB Piping Research Program are to provide experimentally validated analytic techniques and appropriate material properties characterization methods and data to support regulatory activities related to evaluating and ensuring piping integrity

  7. NASA's aviation safety research and technology program

    Science.gov (United States)

    Fichtl, G. H.

    1977-01-01

    Aviation safety is challenged by the practical necessity of compromising inherent factors of design, environment, and operation. If accidents are to be avoided these factors must be controlled to a degree not often required by other transport modes. The operational problems which challenge safety seem to occur most often in the interfaces within and between the design, the environment, and operations where mismatches occur due to ignorance or lack of sufficient understanding of these interactions. Under this report the following topics are summarized: (1) The nature of operating problems, (2) NASA aviation safety research, (3) clear air turbulence characterization and prediction, (4) CAT detection, (5) Measurement of Atmospheric Turbulence (MAT) Program, (6) Lightning, (7) Thunderstorm gust fronts, (8) Aircraft ground operating problems, (9) Aircraft fire technology, (10) Crashworthiness research, (11) Aircraft wake vortex hazard research, and (12) Aviation safety reporting system.

  8. Research program of the Neutrino Research Group. Year 2004

    International Nuclear Information System (INIS)

    2004-01-01

    For the last two decades, neutrino physics has been producing major discoveries including neutrino oscillations. These results gave clear confirmation that active neutrinos oscillate and therefore have mass with three different mass states. This is a very important result showing that the Minimal Standard Model is incomplete and requires an extension which is not yet known. The neutrino research field is very broad and active, at the frontier of today's particle physics. The creation of a Neutrino Research Group (GDR) was proposed in 2004 with the aim of gathering CEA and CNRS research teams working on Neutrino Physics on experimental or theoretical level. This document presents the Research program of the Neutrino Research Group which is divided into 5 working groups with the following activities: 1 - Determination of neutrino parameters; 2 - Physics beyond the standard model; 3 - Neutrinos in the universe; 4 - Accelerators, detection means, R and D and valorisation; 5 - Common tools to all working groups. The research group participating laboratories and teams are listed at the end of the document

  9. Ocean Margins Programs, Phase I research summaries

    Energy Technology Data Exchange (ETDEWEB)

    Verity, P. [ed.

    1994-08-01

    During FY 1992, the DOE restructured its regional coastal-ocean programs into a new Ocean Margins Program (OMP), to: Quantify the ecological and biogeochemical processes and mechanisms that affect the cycling, flux, and storage of carbon and other biogenic elements at the land/ocean interface; Define ocean-margin sources and sinks in global biogeochemical cycles, and; Determine whether continental shelves are quantitatively significant in removing carbon dioxide from the atmosphere and isolating it via burial in sediments or export to the interior ocean. Currently, the DOE Ocean Margins Program supports more than 70 principal and co-principal investigators, spanning more than 30 academic institutions. Research funded by the OMP amounted to about $6.9M in FY 1994. This document is a collection of abstracts summarizing the component projects of Phase I of the OMP. This phase included both research and technology development, and comprised projects of both two and three years duration. The attached abstracts describe the goals, methods, measurement scales, strengths and limitations, and status of each project, and level of support. Keywords are provided to index the various projects. The names, addresses, affiliations, and major areas of expertise of the investigators are provided in appendices.

  10. Seismic safety margin research program. Program plan, Revision II

    International Nuclear Information System (INIS)

    Smith, P.D.; Tokarz, F.J.; Bernreuter, D.L.; Cummings, G.E.; Chou, C.K.; Vagliente, V.N.; Johnson, J.J.; Dong, R.G.

    1978-01-01

    The document has been prepared pursuant to the second meeting of the Senior Research Review Group of the Seismic Safety Margin Research Program (SSMRP), which was held on June 15, 16, 1978. The major portion of the material contained in the document is descriptions of specific subtasks to be performed on the SSMRP. This is preceded by a brief discussion of the objective of the SSMRP and the approach to be used. Specific subtasks to be performed in Phase I of the SSMRP are as follows: (1) plant/site selection, (2) seismic input, (3) soil structure interaction, (4) structural building response, (5) structural sub-system response, (6) fragility, (7) system analysis, and (8) Phase II task definition

  11. The State of Federal Research Funding in Genetics as Reflected by Members of the Genetics Society of America.

    Science.gov (United States)

    Rine, Jasper; Fagen, Adam P

    2015-08-01

    Scientific progress runs on the intellect, curiosity, and passion of its practitioners fueled by the research dollars of its sponsors. The concern over research funding in biology in general and genetics in particular led us to survey the membership of the Genetics Society of America for information about the federal support of genetics at the level of individual principal investigators. The results paint a mosaic of circumstances-some good, others not so good-that describes some of our present challenges with sufficient detail to suggest useful steps that could address the challenges. Copyright © 2015 by the Genetics Society of America.

  12. Identifying future research needs in landscape genetics: Where to from here?

    Science.gov (United States)

    Niko Balkenhol; Felix Gugerli; Sam A. Cushman; Lisette P. Waits; Aurelie Coulon; J. W. Arntzen; Rolf Holderegger; Helene H. Wagner

    2009-01-01

    Landscape genetics is an emerging interdisciplinary field that combines methods and concepts from population genetics, landscape ecology, and spatial statistics. The interest in landscape genetics is steadily increasing, and the field is evolving rapidly. We here outline four major challenges for future landscape genetic research that were identified during an...

  13. Genetic programming over context-free languages with linear constraints for the knapsack problem: first results.

    Science.gov (United States)

    Bruhn, Peter; Geyer-Schulz, Andreas

    2002-01-01

    In this paper, we introduce genetic programming over context-free languages with linear constraints for combinatorial optimization, apply this method to several variants of the multidimensional knapsack problem, and discuss its performance relative to Michalewicz's genetic algorithm with penalty functions. With respect to Michalewicz's approach, we demonstrate that genetic programming over context-free languages with linear constraints improves convergence. A final result is that genetic programming over context-free languages with linear constraints is ideally suited to modeling complementarities between items in a knapsack problem: The more complementarities in the problem, the stronger the performance in comparison to its competitors.

  14. Research and development program, fiscal year 1970

    Energy Technology Data Exchange (ETDEWEB)

    1968-04-01

    The biomedical program of the Laboratory of Nuclear Medicine and Radiation Biology for FY 1970 is conducted within the scope of the following categories: Somatic Effects of Radiation; Combating Detrimental Effects of Radiation; Molecular and Cellular Level Studies; Environmental Radiation Studies; Radiological and Health Physics and Instrumentation; Cancer Research; and Selected Beneficial Applications. The overall objectives of the Laboratory within these areas of the Biology and Medicine Program may be summarized as follows: (1) investigation of the effects of ionizing radiation on systems of biological significance and on living organisms; (2) assessment and study of the immediate and long term consequences of the environmental radioactivity on flora, fauna, and man; (3) development of beneficial uses of ionizing radiation and radioactive substances in medicine and biology; and (4) the conduct of training and educational activities in fields related to the biological and medical aspects of radiation.

  15. Reactor Network Synthesis Using Coupled Genetic Algorithm with the Quasi-linear Programming Method

    OpenAIRE

    Soltani, H.; Shafiei, S.; Edraki, J.

    2016-01-01

    This research is an attempt to develop a new procedure for the synthesis of reactor networks (RNs) using a genetic algorithm (GA) coupled with the quasi-linear programming (LP) method. The GA is used to produce structural configuration, whereas continuous variables are handled using a quasi-LP formulation for finding the best objective function. Quasi-LP consists of LP together with a search loop to find the best reactor conversions (xi), as well as split and recycle ratios (yi). Quasi-LP rep...

  16. Medullary Thyroid Carcinoma Program | Center for Cancer Research

    Science.gov (United States)

    Medullary Thyroid Carcinoma Program Multiple endocrine neoplasia (MEN) types 2A and 2B are rare genetic diseases, which lead to the development of medullary thyroid cancer, usually in childhood. Surgery is the only standard treatment.

  17. Jointly Sponsored Research Program on Energy Related Research

    Energy Technology Data Exchange (ETDEWEB)

    No, author

    2013-12-31

    Cooperative Agreements, DE-FC26-08NT43293, DOE-WRI Cooperative Research and Development Program for Fossil Energy-Related Resources began in June 2009. The goal of the Program was to develop, commercialize, and deploy technologies of value to the nation’s fossil and renewable energy industries. To ensure relevancy and early commercialization, the involvement of an industrial partner was encouraged. In that regard, the Program stipulated that a minimum of 20% cost share be achieved in a fiscal year. This allowed WRI to carry a diverse portfolio of technologies and projects at various development technology readiness levels. Depending upon the maturity of the research concept and technology, cost share for a given task ranged from none to as high as 67% (two-thirds). Over the course of the Program, a total of twenty six tasks were proposed for DOE approval. Over the period of performance of the Cooperative agreement, WRI has put in place projects utilizing a total of $7,089,581 in USDOE funds. Against this funding, cosponsors have committed $7,398,476 in private funds to produce a program valued at $14,488,057. Tables 1 and 2 presented at the end of this section is a compilation of the funding for all the tasks conducted under the program. The goal of the Cooperative Research and Development Program for Fossil Energy-Related Resources was to through collaborative research with the industry, develop or assist in the development of innovative technology solutions that will: • Increase the production of United States energy resources – coal, natural gas, oil, and renewable energy resources; • Enhance the competitiveness of United States energy technologies in international markets and assist in technology transfer; • Reduce the nation's dependence on foreign energy supplies and strengthen both the United States and regional economies; and • Minimize environmental impacts of energy production and utilization. Success of the Program can be measured by

  18. Environmental research program. 1995 Annual report

    Energy Technology Data Exchange (ETDEWEB)

    Brown, N.J.

    1996-06-01

    The objective of the Environmental Research Program is to enhance the understanding of, and mitigate the effects of pollutants on health, ecological systems, global and regional climate, and air quality. The program is multidisciplinary and includes fundamental research and development in efficient and environmentally benign combustion, pollutant abatement and destruction, and novel methods of detection and analysis of criteria and noncriteria pollutants. This diverse group conducts investigations in combustion, atmospheric and marine processes, flue-gas chemistry, and ecological systems. Combustion chemistry research emphasizes modeling at microscopic and macroscopic scales. At the microscopic scale, functional sensitivity analysis is used to explore the nature of the potential-to-dynamics relationships for reacting systems. Rate coefficients are estimated using quantum dynamics and path integral approaches. At the macroscopic level, combustion processes are modelled using chemical mechanisms at the appropriate level of detail dictated by the requirements of predicting particular aspects of combustion behavior. Parallel computing has facilitated the efforts to use detailed chemistry in models of turbulent reacting flow to predict minor species concentrations.

  19. Plant lifetime management and research program

    International Nuclear Information System (INIS)

    Sakai, K.; Nagayama, M.

    1993-01-01

    The importance of nuclear power generation has been increasing in Japan. Because the lower generation cost and more stable fuel supply, in comparison with the case of fossil plants, are beneficial to Japan which has scarce natural resources. In addition, nuclear power generation is expected to help reduce carbon dioxide emission which causes global warming. In these circumstances, the safe and stable operations of nuclear power plants are of prime importance, and the frequency of unscheduled shutdown has been kept low in Japan as a result of thorough periodic inspections supported by aging management. This paper covers the development process of the aging management program and related research programs in The Kansai Electric Power Co., Inc. (KEPCO). KEPCO runs 11 nuclear power units (PWR). A Table shows the commencement date of commercial operation and operating hours for each unit. The early plants, such as Mihama-2 Unit, have been operated for more than 100,000 hours and are in the phase of aging management. Accordingly, we have been conducting aging management programs since 1987. in order to identify age-related degradation and work out countermeasures.The aging management programs have ensured safe and stable operation of nuclear power plants. Each result of the lifetime assessment has provided the information which helps establishing maintenance programs. For example, the result of the lifetime assessment has been reflected to the intervals of overhaulings and inspections, and the replacement timing of some components. In the future activities of aging management should be revised and should focus lifetime assessment on components which provoke difficulties in inspections because of high radiation exposure or high inspection cost

  20. A Community - Centered Astronomy Research Program

    Science.gov (United States)

    Boyce, Pat; Boyce, Grady

    2017-06-01

    The Boyce Research Initiatives and Education Foundation (BRIEF) is providing semester-long, hands-on, astronomy research experiences for students of all ages that results in their publishing peer-reviewed papers. The course in astronomy and double star research has evolved from a face-to-face learning experience with two instructors to an online - hybrid course that simultaneously supports classroom instruction at a variety of schools in the San Diego area. Currently, there are over 65 students enrolled in three community colleges, seven high schools, and one university as well as individual adult learners. Instructional experience, courseware, and supporting systems were developed and refined through experience gained in classroom settings from 2014 through 2016. Topics of instruction include Kepler's Laws, basic astrometry, properties of light, CCD imaging, use of filters for varying stellar spectral types, and how to perform research, scientific writing, and proposal preparation. Volunteer instructors were trained by taking the course and producing their own research papers. An expanded program was launched in the fall semester of 2016. Twelve papers from seven schools were produced; eight have been accepted for publication by the Journal of Double Observations (JDSO) and the remainder are in peer review. Three additional papers have been accepted by the JDSO and two more are in process papers. Three college professors and five advanced amateur astronomers are now qualified volunteer instructors. Supporting tools are provided by a BRIEF server and other online services. The server-based tools range from Microsoft Office and planetarium software to top-notch imaging programs and computational software for data reduction for each student team. Observations are performed by robotic telescopes worldwide supported by BRIEF. With this success, student demand has increased significantly. Many of the graduates of the first semester course wanted to expand their

  1. Gas Hydrates Research Programs: An International Review

    Energy Technology Data Exchange (ETDEWEB)

    Jorge Gabitto; Maria Barrufet

    2009-12-09

    Gas hydrates sediments have the potential of providing a huge amount of natural gas for human use. Hydrate sediments have been found in many different regions where the required temperature and pressure conditions have been satisfied. Resource exploitation is related to the safe dissociation of the gas hydrate sediments. Basic depressurization techniques and thermal stimulation processes have been tried in pilot efforts to exploit the resource. There is a growing interest in gas hydrates all over the world due to the inevitable decline of oil and gas reserves. Many different countries are interested in this valuable resource. Unsurprisingly, developed countries with limited energy resources have taken the lead in worldwide gas hydrates research and exploration. The goal of this research project is to collect information in order to record and evaluate the relative strengths and goals of the different gas hydrates programs throughout the world. A thorough literature search about gas hydrates research activities has been conducted. The main participants in the research effort have been identified and summaries of their past and present activities reported. An evaluation section discussing present and future research activities has also been included.

  2. New hybrid systems: strategy and research programs

    International Nuclear Information System (INIS)

    Thomas, J.B.

    2001-01-01

    This short article gives a status of research and experimental programs concerning new hybrid systems. A hybrid system is made up of a subcritical core, a spallation target and of a particle accelerator that delivers a proton beam. The main asset of hybrid systems is to provide a large reactivity margin that would be very valuable to transmute actinide nuclei efficiently. As a consequence hybrid systems could be considered as actinide burner reactors integrated to a large population of classical nuclear reactors dedicated to electricity production. (A.C.)

  3. PISCES Program: Summary of research, 1988

    International Nuclear Information System (INIS)

    1988-10-01

    This paper discusses the research of the PISCES Program. Topics discussed are: deuterium pumping by C-C composites and graphites; reduced particle recycling from grooved graphite surfaces; surface analysis of graphite tiles exposed in tokamaks; erosion behavior of redeposition layers from tokamaks (tokamakium); high temperature erosion of graphite; collaboration on TFTR probe measurements of implanted D; spectroscopic studies of carbon containing molecules; presheath profile measurements; biased limiter/divertor experiments; particle transport in the CCT tokamak edge plasma; and experimental studies of biased divertors and limiters. 26 refs., 23 figs

  4. System Response Analysis and Model Order Reduction, Using Conventional Method, Bond Graph Technique and Genetic Programming

    Directory of Open Access Journals (Sweden)

    Lubna Moin

    2009-04-01

    Full Text Available This research paper basically explores and compares the different modeling and analysis techniques and than it also explores the model order reduction approach and significance. The traditional modeling and simulation techniques for dynamic systems are generally adequate for single-domain systems only, but the Bond Graph technique provides new strategies for reliable solutions of multi-domain system. They are also used for analyzing linear and non linear dynamic production system, artificial intelligence, image processing, robotics and industrial automation. This paper describes a unique technique of generating the Genetic design from the tree structured transfer function obtained from Bond Graph. This research work combines bond graphs for model representation with Genetic programming for exploring different ideas on design space tree structured transfer function result from replacing typical bond graph element with their impedance equivalent specifying impedance lows for Bond Graph multiport. This tree structured form thus obtained from Bond Graph is applied for generating the Genetic Tree. Application studies will identify key issues and importance for advancing this approach towards becoming on effective and efficient design tool for synthesizing design for Electrical system. In the first phase, the system is modeled using Bond Graph technique. Its system response and transfer function with conventional and Bond Graph method is analyzed and then a approach towards model order reduction is observed. The suggested algorithm and other known modern model order reduction techniques are applied to a 11th order high pass filter [1], with different approach. The model order reduction technique developed in this paper has least reduction errors and secondly the final model retains structural information. The system response and the stability analysis of the system transfer function taken by conventional and by Bond Graph method is compared and

  5. INEL BNCT research program: Annual report, 1995

    International Nuclear Information System (INIS)

    Venhuizen, J.R.

    1996-04-01

    This report is a summary of the progress and research produced for the Idaho National Engineering Laboratory (INEL) Boron Neutron Capture Therapy (BNCT) Research Program for calendar year 1995. Contributions from the principal investigators about their individual projects are included, specifically, physics (treatment planning software, real-time neutron beam measurement dosimetry), and radiation biology (large animal models efficacy studies). Design of a reactor based epithermal neutron extraction facility is discussed in detail. Final results of boron magnetic resonance imagining is included for both borocaptate sodium (BSH) and boronophenylalanine (BPA) in rats, and BSH in humans. Design of an epithermal neutron facility using electron linear accelerators is presented, including a treatise on energy removal from the beam target. Information on the multiple fraction injection of BSH in rats is presented

  6. INEL BNCT research program: Annual report, 1995

    Energy Technology Data Exchange (ETDEWEB)

    Venhuizen, J.R. [ed.

    1996-04-01

    This report is a summary of the progress and research produced for the Idaho National Engineering Laboratory (INEL) Boron Neutron Capture Therapy (BNCT) Research Program for calendar year 1995. Contributions from the principal investigators about their individual projects are included, specifically, physics (treatment planning software, real-time neutron beam measurement dosimetry), and radiation biology (large animal models efficacy studies). Design of a reactor based epithermal neutron extraction facility is discussed in detail. Final results of boron magnetic resonance imagining is included for both borocaptate sodium (BSH) and boronophenylalanine (BPA) in rats, and BSH in humans. Design of an epithermal neutron facility using electron linear accelerators is presented, including a treatise on energy removal from the beam target. Information on the multiple fraction injection of BSH in rats is presented.

  7. INEL BNCT Research Program annual report 1994

    International Nuclear Information System (INIS)

    Venhuizen, J.R.

    1995-11-01

    This report is a summary of the progress and research produced for the Idaho National Engineering Laboratory (INEL) Boron Neutron Capture Therapy (BNCT) Research Program for calendar year 1994. Contributions from the principal investigators about their individual projects are included, specifically, chemistry (pituitary tumor studies, boron drug development including liposomes, lipoproteins, and carboranylalanine derivatives), pharmacology (murine screenings, toxicity testing, ICP-AES analysis of biological samples), physics (treatment planning software, neutron beam and filter design, neutron beam measurement dosimetry), and radiation biology (small and large animal models tissue studies and efficacy studies). Information on the potential toxicity of BSH and BPA is presented and results of 21 spontaneous tumor bearing dogs that have been treated with BNCT at Brookhaven National Laboratory (BNL) are discussed. Several boron carrying drugs exhibiting good tumor uptake are described. Significant progress in the potential of treating pituitary tumors is presented. Highlights from the First International Workshop on Accelerator-Based Neutron Sources for BNCT are included

  8. INEL BNCT research program publications, 1993

    International Nuclear Information System (INIS)

    1994-05-01

    This document is a collection of the published reports describing research supporting the Idaho National Engineering Laboratory Boron Neutron Capture Therapy Research Program for calendar year 1993. Contributions from the principal investigators are included, covering chemistry (pituitary tumor studies, boron drug development including liposomes, lipoproteins, and carboranylalanine derivatives), pharmacology (murine screenings, toxicity testing, ICP-AES analysis of biological samples), physics (radiation dosimetry software, neutron beam and filter design, neutron beam measurement dosimetry), and radiation biology (tissue and efficacy studies of small and large animal models). These reports have previously appeared in the book: Advances in Neutron Capture Therapy, edited by A. H. Soloway, R. F. Barth, D. E. Carpenter, Plenum Press, 1993. Reports have also appeared in three journals: Angewandte Chemie, Strahlentherapie und Onkologie, and Nuclear Science and Engineering. This individual papers have been indexed separately elsewhere

  9. Swarm, genetic and evolutionary programming algorithms applied to multiuser detection

    Directory of Open Access Journals (Sweden)

    Paul Jean Etienne Jeszensky

    2005-02-01

    Full Text Available In this paper, the particles swarm optimization technique, recently published in the literature, and applied to Direct Sequence/Code Division Multiple Access systems (DS/CDMA with multiuser detection (MuD is analyzed, evaluated and compared. The Swarm algorithm efficiency when applied to the DS-CDMA multiuser detection (Swarm-MuD is compared through the tradeoff performance versus computational complexity, being the complexity expressed in terms of the number of necessary operations in order to reach the performance obtained through the optimum detector or the Maximum Likelihood detector (ML. The comparison is accomplished among the genetic algorithm, evolutionary programming with cloning and Swarm algorithm under the same simulation basis. Additionally, it is proposed an heuristics-MuD complexity analysis through the number of computational operations. Finally, an analysis is carried out for the input parameters of the Swarm algorithm in the attempt to find the optimum parameters (or almost-optimum for the algorithm applied to the MuD problem.

  10. Flow discharge prediction in compound channels using linear genetic programming

    Science.gov (United States)

    Azamathulla, H. Md.; Zahiri, A.

    2012-08-01

    SummaryFlow discharge determination in rivers is one of the key elements in mathematical modelling in the design of river engineering projects. Because of the inundation of floodplains and sudden changes in river geometry, flow resistance equations are not applicable for compound channels. Therefore, many approaches have been developed for modification of flow discharge computations. Most of these methods have satisfactory results only in laboratory flumes. Due to the ability to model complex phenomena, the artificial intelligence methods have recently been employed for wide applications in various fields of water engineering. Linear genetic programming (LGP), a branch of artificial intelligence methods, is able to optimise the model structure and its components and to derive an explicit equation based on the variables of the phenomena. In this paper, a precise dimensionless equation has been derived for prediction of flood discharge using LGP. The proposed model was developed using published data compiled for stage-discharge data sets for 394 laboratories, and field of 30 compound channels. The results indicate that the LGP model has a better performance than the existing models.

  11. Sub-Saharan centralized biorepository for genetic and genomic research.

    Science.gov (United States)

    Gasmelseed, Nagla; Elsir, Afrah Awad; Deblasio, Pasquale; Biunno, Ida

    2012-04-15

    Quality-assessed biomedical samples are essential for academia- and industry driven research on human diseases. The etiologies and the molecular genetic factors relevant in African diseases, including both infections and complex degenerative diseases as well as cancer, need to be studied using well annotated and well-preserved biosamples acquired from native African ethnic groups and compare the results with non-African populations and/or with Afro-Americans. However, a number of difficulties negatively impact on the possibility to obtain clinically annotated biological samples in most Sub-Saharan African countries. This is mainly due to major organizational problems, lack of clinical centres that can dedicate resources to research, as well as lack of facilities in which biomaterials can be properly processed and safely stored. Harmonization of biosample acquisition, storage phenotyping schemes and biocomputer infrastructures are the principal objectives of biological resource centers (BRCs). BRCs comprise biobanks of different formats (collection of blood, DNA, tissues, etc., annotated with medical, environmental, life-style and follow up data) a fundamental tool for molecular epidemiological studies aiming to increase excellence and efficacy of biomedical results, drug development and public health. BRCs provide large and highly controlled biomolecular resources necessary to meet the "omics" scientific platforms. Sudan may be a candidate nation to host such infrastructure, in view of its strategic geographical position and the already existing simple biobanking experiences connected with research groups in Central Sudan. Here, we describe the potential role of biobanks in African genetic studies aiming to dissect the eziopathogenesis of complex diseases in relation to environmental and life-style factors. Copyright © 2010 Elsevier B.V. All rights reserved.

  12. Basis for snubber aging research: Nuclear Plant Aging Research Program

    International Nuclear Information System (INIS)

    Brown, D.P.; Palmer, G.R.; Werry, E.V.; Blahnik, D.E.

    1990-01-01

    This report describes a research plan to address the safety concerns of aging in snubbers used on piping and equipment in commercial nuclear power plants. The work is to be performed under Phase 2 of the Snubber Aging Study of the Nuclear Plant Aging Research Program of the US Nuclear Regulatory Commission with the Pacific Northwest Laboratory (PNL) as the prime contractor. Research conducted by PNL under Phase 1 provided an initial assessment of snubber operating experience and was primarily based on a review of licensee event reports. The work proposed is an extension of Phase 1 and includes research at nuclear power plants and in test laboratories. Included is technical background on the design and use of snubbers in commercial nuclear power applications; the primary failure modes of both hydraulic and mechanical snubbers are discussed. The anticipated safety, technical, and regulatory benefits of the work, along with concerns of the NRC and the utilities, are also described. 21 refs., 7 figs., 1 tab

  13. Introduction and overview of research program

    International Nuclear Information System (INIS)

    Anon.

    1984-01-01

    The research goals have remained the same over the last several years: (1) to provide data which rigorously test proton + nucleus (pA) reaction models appropriate for medium energies (nonrelativistic and relativistic); (2) to provide data and appropriate analyses of it to obtain new, unambiguous information about the details of nuclear structure and reaction mechanisms (this information, in turn, can be used to test fundamental models of nuclear structure and effective interactions); (3) to provide proton + nucleon data which help constrain the nucleon-nucleon phase shift solutions, and (4) to develop and improve the pA models themselves. For this reason, since its conception in 1976, our program has held to the pragmatic philosophy that precise, reliable experimental data and state-of-the-art theoretical analyses are of equal importance. Thus, experiment and theory have merged to play complementary and closely linked roles in our studies to date; this philosophy is not expected to change in the future. A schematic overview indicating the framework in which the research program operates is shown and discussed

  14. Population genetics analysis using R and the Geneland program

    DEFF Research Database (Denmark)

    Guillot, Gilles; Santos, Filipe; Estoup, Arnaud

    2011-01-01

    Geneland program documentation 2011 Program distributed under GNU license as an R package on the Comprehensive R Archive Network.......Geneland program documentation 2011 Program distributed under GNU license as an R package on the Comprehensive R Archive Network....

  15. A proposal of neutron science research program

    International Nuclear Information System (INIS)

    Suzuki, Y.; Yasuda, H.; Tone, T.; Mizumoto, M.

    1996-01-01

    A conception of Neutron Science Research Program (NSRP) has been proposed in Japan Atomic Energy Research Institute (JAERI) since 1994 as a future big project. The NSRP aims at exploring new basic science and nuclear energy science by a high-intensity proton accelerator. It is a complex composed of a proton linac and seven research facilities with each different target system. The proton linac is required to supply the high-intensity proton beam with energy up to 1.5 GeV and current 10 mA on average. The scientific research facilities proposed, are as follows: Thermal/Cold Neutron Facility for the neutron scattering experiments, Neutron Irradiation Facility for materials science, Neutron Physics Facility for nuclear data measurement, OMEGA/Nuclear Energy Facility for nuclear waste transmutation and fuel breeding, Spallation RI Beam Facility for nuclear physics, Meson/Muon Facility for meson and muon physics and their applications and Medium Energy Beam Facility for accelerator technology development, medical use, etc. Research and development have been carried out for the components of the injector system of the proton linac; an ion source, an RFQ linac and a part of DTL linac. The conceptual design work and research and development activities for NSRP have been started in the fiscal year, 1996. Construction term will be divided into two phases; the completion of the first phase is expected in 2003, when the proton linac will produce 1.5 GeV, 1 mA beam by reflecting the successful technology developments. (author)

  16. Research Experiences in Community College Science Programs

    Science.gov (United States)

    Beauregard, A.

    2011-12-01

    research with my community college students by partnering with a research oceanographer. Through this partnership, students have had access to an active oceanographic researcher through classroom visits, use of data in curriculum, and research/cruise progress updates. With very little research activity currently going on at the community college, this "window" into scientific research is invaluable. Another important aspect of this project is the development of a summer internship program that has allowed four community college students to work directly with an oceanographer in her lab for ten weeks. This connection of community college students with world-class scientists in the field promotes better understanding of research and potentially may encourage more students to major in the sciences. In either approach, the interaction with scientists at different stages of their careers, from undergraduate and graduate students at universities to post docs and research scientists, also provides community college students with the opportunity to gain insight into possible career pathways. For both majors and non-majors, a key outcome of such experiences will be gaining experience in using inquiry and reasoning through the scientific method and becoming comfortable with data and technology.

  17. Creation of an American Holistic Nurses Association research consultation program.

    Science.gov (United States)

    Robertson, Sue; Clingerman, Evelyn; Zahourek, Rothlyn P; Mariano, Carla; Lange, Bernadette

    2012-12-01

    A goal of the American Holistic Nurses Association (AHNA) Research Committee is to prepare holistic nurses to conduct holistic nursing research. This article describes the creation of a Research Consultation Program and how the knowledge gained from the program will contribute to the development of a formal research mentor program.

  18. National Research Council Research Associateships Program with Methane Hydrates Fellowships Program/National Energy Technology Laboratory

    Energy Technology Data Exchange (ETDEWEB)

    Basques, Eric O. [National Academy of Sciences, Washington, DC (United States)

    2014-03-20

    This report summarizes work carried out over the period from July 5, 2005-January 31, 2014. The work was carried out by the National Research Council Research Associateships Program of the National Academies, under the US Department of Energy's National Energy Technology Laboratory (NETL) program. This Technical Report consists of a description of activity from 2005 through 2014, broken out within yearly timeframes, for NRC/NETL Associateships researchers at NETL laboratories which includes individual tenure reports from Associates over this time period. The report also includes individual tenure reports from associates over this time period. The report also includes descriptions of program promotion efforts, a breakdown of the review competitions, awards offered, and Associate's activities during their tenure.

  19. Genetics

    International Nuclear Information System (INIS)

    Hubitschek, H.E.

    1975-01-01

    Progress is reported on the following research projects: genetic effects of high LET radiations; genetic regulation, alteration, and repair; chromosome replication and the division cycle of Escherichia coli; effects of radioisotope decay in the DNA of microorganisms; initiation and termination of DNA replication in Bacillus subtilis; mutagenesis in mouse myeloma cells; lethal and mutagenic effects of near-uv radiation; effect of 8-methoxypsoralen on photodynamic lethality and mutagenicity in Escherichia coli; DNA repair of the lethal effects of far-uv; and near uv irradiation of bacterial cells

  20. Are Leadership and Management Essential for Good Research? An Interview Study of Genetic Researchers.

    Science.gov (United States)

    Antes, Alison L; Mart, Adelina; DuBois, James M

    2016-12-01

    Principal investigators are responsible for a myriad of leadership and management activities in their work. The practices they use to navigate these responsibilities ultimately influence the quality and integrity of research. However, leadership and management roles in research have received scant empirical examination. Semi-structured interviews with 32 National Institutes of Health (NIH)-funded genetic researchers revealed that they considered leadership and management essential for effective research, but their scientific training inadequately prepared them. We also report management practices that the researchers described using in their labs, as well as their perceptions of a proposed intervention to enhance laboratory leadership. These findings suggest best practices for the research community, future directions for scientific training, and implications for research on leadership and management in science.

  1. Are Leadership and Management Essential for Good Research? An Interview Study of Genetic Researchers

    Science.gov (United States)

    Antes, Alison L.; Mart, Adelina; DuBois, James M.

    2016-01-01

    Principal investigators are responsible for a myriad of leadership and management activities in their work. The practices they employ to navigate these responsibilities ultimately influence the quality and integrity of research. However, leadership and management roles in research have received scant empirical examination. Semi-structured interviews with 32 National Institutes of Health (NIH)-funded genetic researchers revealed that they considered leadership and management essential for effective research, but their scientific training inadequately prepared them. We also report management practices that the researchers described employing in their labs, as well as their perceptions of a proposed intervention to enhance laboratory leadership. These findings suggest best practices for the research community, future directions for scientific training, and implications for research on leadership and management in science. PMID:27646401

  2. RESEARCH ARTICLE Genetic control of Yellow Vein Mosaic Virus ...

    Indian Academy of Sciences (India)

    sony

    Qualitative genetic analysis done on the basis of segregation pattern of ..... First author acknowledges the financial help rendered by Jawaharlal Nehru Memorial Fund, New. Delhi ... Indian Journal of Genetics and Plant Breeding 22, 137-38.

  3. Severe Accident Research Program plan update

    International Nuclear Information System (INIS)

    1992-12-01

    In August 1989, the staff published NUREG-1365, ''Revised Severe Accident Research Program Plan.'' Since 1989, significant progress has been made in severe accident research to warrant an update to NUREG-1365. The staff has prepared this SARP Plan Update to: (1) Identify those issues that have been closed or are near completion, (2) Describe the progress in our understanding of important severe accident phenomena, (3) Define the long-term research that is directed at improving our understanding of severe accident phenomena and developing improved methods for assessing core melt progression, direct containment heating, and fuel-coolant interactions, and (4) Reflect the growing emphasis in two additional areas--advanced light water reactors, and support for the assessment of criteria for containment performance during severe accidents. The report describes recent major accomplishments in understanding the underlying phenomena that can occur during a severe accident. These include Mark I liner failure, severe accident scaling methodology, source term issues, core-concrete interactions, hydrogen transport and combustion, TMI-2 Vessel Investigation Project, and direct containment heating. The report also describes the major planned activities under the SARP over the next several years. These activities will focus on two phenomenological issues (core melt progression, and fuel-coolant interactions and debris coolability) that have significant uncertainties that impact our understanding and ability to predict severe accident phenomena and their effect on containment performance SARP will also focus on severe accident code development, assessment and validation. As the staff completes the research on severe accident issues that relate to current generation reactors, continued research will focus on efforts to independently evaluate the capability of new advanced light water reactor designs to withstand severe accidents

  4. DOE-EERC jointly sponsored research program

    Energy Technology Data Exchange (ETDEWEB)

    Hendrikson, J.G.; Sondreal, E.A.

    1999-09-01

    U.S. Department of Energy (DOE) Cooperative Agreement DE-FC21-93MC30098 funded through the Office of Fossil Energy and administered at the Federal Energy Technology Center (FETC) supported the performance of a Jointly Sponsored Research Program (JSRP) at the Energy and Environmental Research Center (EERC) with a minimum 50% nonfederal cost share to assist industry in commercializing and effectively applying efficient, nonpolluting energy technologies that can compete effectively in meeting market demands for clean fuels, chemical feedstocks, and electricity in the 21st century. The objective of the JSRP was to advance the deployment of advanced technologies for improving energy efficiency and environmental performance through jointly sponsored research on topics that would not be adequately addressed by the private sector alone. Examples of such topics include the barriers to hot-gas cleaning impeding the deployment of high-efficiency power systems and the search for practical means for sequestering CO{sub 2} generated by fossil fuel combustion. The selection of particular research projects was guided by a combination of DOE priorities and market needs, as provided by the requirement for joint venture funding approved both by DOE and the private sector sponsor. The research addressed many different energy resource and related environmental problems, with emphasis directed toward the EERC's historic lead mission in low-rank coals (LRCs), which represent approximately half of the U.S. coal resources in the conterminous states, much larger potential resources in Alaska, and a major part of the energy base in the former U.S.S.R., East Central Europe, and the Pacific Rim. The Base and JSRP agreements were tailored to the growing awareness of critical environmental issues, including water supply and quality, air toxics (e.g., mercury), fine respirable particulate matter (PM{sub 2.5}), and the goal of zero net CO{sub 2} emissions.

  5. Stigmatization of carrier status: social implications of heterozygote genetic screening programs.

    Science.gov (United States)

    Kenen, R H; Schmidt, R M

    1978-01-01

    Possible latent psychological and social consequences ensuing from genetic screening programs need to be investigated during the planning phase of national genetic screening programs. The relatively few studies which have been performed to determine psychological, social, and economic consequences resulting from a genetic screening program are reviewed. Stigmatization of carrier-status, having major psychosocial implications in heterozygote genetic screening programs, is discussed and related to Erving Goffman's work in the area of stigmatization. Questions are raised regarding the relationship between such variables as religiosity and sex of the individual and acceptance of the status of newly identified carrier of a mutant gene. Severity of the deleterious gene and visibility of the carrier status are two important factors to consider in an estimation of potential stigma. Specific implications are discussed for four genetic diseases: Tay-Sachs, Sickle-Cell Anemia, Huntington's disease and Hemophilia. PMID:152585

  6. Seismic safety margin research program. Program plan, Revision I

    International Nuclear Information System (INIS)

    Smith, P.D.; Tokarz, F.J.; Bernreuter, D.L.; Cummings, G.E.; Chou, C.K.; Vagliente, V.N.

    1978-01-01

    The overall objective of the SSMRP is to develop mathematical models that realistically predict the probability of radioactive releases from seismically induced events in nuclear power plants. These models will be used for four purposes: (1) To perform sensitivity studies to determine the weak links in seismic methodology. The weak links will then be improved by research and development. (2) To estimate the probability of release for a plant. It is believed that the major difficulty in the program will be to obtain acceptably small confidence limits on the probability of release. (3) To estimate the conservatisms in the Standard Review Plan (SRP) seismic design methodology. This will be done by comparing the results of the SRP methodology and the methodology resulting from the research and development in (1). (4) To develop an improved seismic design methodology based on probability. The Phase I objective proposed in this report is to develop mathematical models which will accomplish the purposes No. 1 and No. 2 with simplified assumptions such as linear elastic analysis, limited assessment on component fragility (considering only accident sequences leading to core melt), and simplified safety system

  7. Prediksi Nilai Tukar Rupiah Terhadap US Dollar Menggunakan Metode Genetic Programming

    Directory of Open Access Journals (Sweden)

    Daneswara Jauhari

    2016-12-01

    Exchange currency rate has a wide influence in the economy of a country, both domestically or internationally. The importance of knowing the pattern of exchange rate against the IDR to USD could help the economic growth due to foreign trade involves the use of currencies of different countries. Therefore, we need an application that can predict the value of IDR against the USD in the future. In this research, the authors use genetic programming (GP method which produces solutions (chromosome that obtained from the evaluation of exchange rate and then this solution used as an approximation or prediction of currency exchange rate in the future. These solutions formed from the combination of the set terminal and the set of function that generated randomly. After testing by the number popsize and different iterations, it was found that the GP algorithm can predict the value of the rupiah against the US Dollar with a very good, judging from the value of Mean Absolute Percentage Error (MAPE generated by 0.08%. This research can be developed even better by adding terminal parameters and operating parameters so they can add variation calculation results. Keywords:  prediction, exchange currency rate, genetic programming, MAPE.

  8. Research Experience in Psychiatry Residency Programs Across Canada: Current Status

    Science.gov (United States)

    Shanmugalingam, Arany; Ferreria, Sharon G; Norman, Ross M G; Vasudev, Kamini

    2014-01-01

    Objective: To determine the current status of research experience in psychiatry residency programs across Canada. Method: Coordinators of Psychiatric Education (COPE) resident representatives from all 17 psychiatry residency programs in Canada were asked to complete a survey regarding research training requirements in their programs. Results: Among the 17 COPE representatives, 15 completed the survey, representing 88% of the Canadian medical schools that have a psychiatry residency program. Among the 15 programs, 11 (73%) require residents to conduct a scholarly activity to complete residency. Some of these programs incorporated such a requirement in the past 5 years. Ten respondents (67%) reported availability of official policy and (or) guidelines on resident research requirements. Among the 11 programs that have a research requirement, 10 (91%) require residents to complete 1 scholarly activity; 1 requires completion of 2 scholarly activities. Eight (53%) residency programs reported having a separate research track. All of the programs have a research coordinator and 14 (93%) programs provide protected time to residents for conducting research. The 3 most common types of scholarly activities that qualify for the mandatory research requirement are a full independent project (10 programs), a quality improvement project (8 programs), and assisting in a faculty project (8 programs). Six programs expect their residents to present their final work in a departmental forum. None of the residency programs require publication of residents’ final work. Conclusions: The current status of the research experience during psychiatry residency in Canada is encouraging but there is heterogeneity across the programs. PMID:25565474

  9. Aquaculture-oriented genetic researches in abalone: Current status ...

    African Journals Online (AJOL)

    Hybridization, triploidization and genetic mapping were also briefly reviewed as aquaculture-oriented genetic techniques to improve growth and other commercially important traits. Cryopreservation and other biotechnologies potentially applicable on genetic improvement were also briefly mentioned as supporting tools for ...

  10. A genetic programming approach for Burkholderia Pseudomallei diagnostic pattern discovery

    Science.gov (United States)

    Yang, Zheng Rong; Lertmemongkolchai, Ganjana; Tan, Gladys; Felgner, Philip L.; Titball, Richard

    2009-01-01

    Motivation: Finding diagnostic patterns for fighting diseases like Burkholderia pseudomallei using biomarkers involves two key issues. First, exhausting all subsets of testable biomarkers (antigens in this context) to find a best one is computationally infeasible. Therefore, a proper optimization approach like evolutionary computation should be investigated. Second, a properly selected function of the antigens as the diagnostic pattern which is commonly unknown is a key to the diagnostic accuracy and the diagnostic effectiveness in clinical use. Results: A conversion function is proposed to convert serum tests of antigens on patients to binary values based on which Boolean functions as the diagnostic patterns are developed. A genetic programming approach is designed for optimizing the diagnostic patterns in terms of their accuracy and effectiveness. During optimization, it is aimed to maximize the coverage (the rate of positive response to antigens) in the infected patients and minimize the coverage in the non-infected patients while maintaining the fewest number of testable antigens used in the Boolean functions as possible. The final coverage in the infected patients is 96.55% using 17 of 215 (7.4%) antigens with zero coverage in the non-infected patients. Among these 17 antigens, BPSL2697 is the most frequently selected one for the diagnosis of Burkholderia Pseudomallei. The approach has been evaluated using both the cross-validation and the Jack–knife simulation methods with the prediction accuracy as 93% and 92%, respectively. A novel approach is also proposed in this study to evaluate a model with binary data using ROC analysis. Contact: z.r.yang@ex.ac.uk PMID:19561021

  11. CDPOP: A spatially explicit cost distance population genetics program

    Science.gov (United States)

    Erin L. Landguth; S. A. Cushman

    2010-01-01

    Spatially explicit simulation of gene flow in complex landscapes is essential to explain observed population responses and provide a foundation for landscape genetics. To address this need, we wrote a spatially explicit, individual-based population genetics model (CDPOP). The model implements individual-based population modelling with Mendelian inheritance and k-allele...

  12. DIII-D research program progress

    Energy Technology Data Exchange (ETDEWEB)

    Stambaugh, R.D.

    1990-11-01

    A summary of highlights of the research on the DIII-D tokamak in the last two years is given. At low q, toroidal beta ({beta}{sub T}) has reached 11%. At high q, {epsilon}{beta}{sub p} has reached 1.8. DIII-D data extending from one regime to the other show the beta limit is at least {beta}{sub T}(%) {ge} 3.5 I/aB (MA, m, T). Prospects for using H-mode in future devices have been enhanced. The discovery of negative edge electric fields and associated turbulence suppression have become part of an emerging theory of H-mode. Long pulse (10 second) H-mode with impurity control has been demonstrated. Radial sweeping of the divertor strike points and gas puffing under the X-point have lowered peak divertor plate heat fluxes a factor of 3 and 2 respectively. T{sub i} = 17 keV has been reached in a hot ion H-mode. Electron cyclotron current drive (ECCD) has produced up to 70 kA of driven current. Program elements now beginning are fast wave current drive (FWCD) and an advanced divertor program (ADP). 38 refs., 10 figs.

  13. FHWA research and technology evaluation program summary report spring 2016

    Science.gov (United States)

    2016-08-01

    This report summarizes the 16 evaluations being conducted by the Volpe National Transportation Systems Center on behalf of FHWAs Research and Technology Program. The FHWA R&T Program furthers the Turner-Fairbank Highway Research Centers goal of...

  14. The SSI reviews of the SKB research programs 1992

    International Nuclear Information System (INIS)

    Jensen, Mikael.

    1993-02-01

    The Swedish Radiation Protection Institute (SSI) has scrutinized the research programs 1992 of the Swedish Nuclear Fuel and Waste Management Co (SKB). The judgement is that SKB has both the competence and resources to perform the presented research programs

  15. Transit Marketing : A Program of Research, Demonstration and Communication

    Science.gov (United States)

    1985-04-01

    This report recommends a five-year program of research, demonstration, and communication to improve the effectiveness of marketing practice in the U.S. transit industry. The program is oriented toward the development of improved market research tools...

  16. INEL BNCT Research Program annual report, 1992

    Energy Technology Data Exchange (ETDEWEB)

    Venhuizen, J.R. [ed.

    1993-05-01

    This report is a summary of the progress and research produced for the Idaho National Engineering Laboratory Boron Neutron Capture Therapy (BNCT) Research Program for calendar year 1992. Contributions from all the principal investigators about their individual projects are included, specifically, chemistry (pituitary tumor targeting compounds, boron drug development including liposomes, lipoproteins, and carboranylalanine derivatives), pharmacology (murine screenings, toxicity testing, inductively coupled plasma-atomic emission spectroscopy (ICP-AES) analysis of biological samples), physics (radiation dosimetry software, neutron beam and filter design, neutron beam measurement dosimetry), and radiation biology (small and large animal models tissue studies and efficacy studies). Information on the potential toxicity of borocaptate sodium and boronophenylalanine is presented, results of 21 spontaneous-tumor-bearing dogs that have been treated with BNCT at the Brookhaven National Laboratory (BNL) Medical Research Reactor (BMRR) are discussed, and predictions for an epithermal-neutron beam at the Georgia Tech Research Reactor (GTRR) are shown. Cellular-level boron detection and localization by secondary ion mass spectrometry, sputter-initiated resonance ionization spectroscopy, low atomization resonance ionization spectroscopy, and alpha track are presented. Boron detection by ICP-AES is discussed in detail. Several boron carrying drugs exhibiting good tumor uptake are described. Significant progress in the potential of treating pituitary tumors with BNCT is presented. Measurement of the epithermal-neutron flux at BNL and comparison to predictions are shown. Calculations comparing the GTRR and BMRR epithermal-neutron beams are also presented. Individual progress reports described herein are separately abstracted and indexed for the database.

  17. INEL BNCT Research Program annual report, 1992

    International Nuclear Information System (INIS)

    Venhuizen, J.R.

    1993-05-01

    This report is a summary of the progress and research produced for the Idaho National Engineering Laboratory Boron Neutron Capture Therapy (BNCT) Research Program for calendar year 1992. Contributions from all the principal investigators about their individual projects are included, specifically, chemistry (pituitary tumor targeting compounds, boron drug development including liposomes, lipoproteins, and carboranylalanine derivatives), pharmacology (murine screenings, toxicity testing, inductively coupled plasma-atomic emission spectroscopy (ICP-AES) analysis of biological samples), physics (radiation dosimetry software, neutron beam and filter design, neutron beam measurement dosimetry), and radiation biology (small and large animal models tissue studies and efficacy studies). Information on the potential toxicity of borocaptate sodium and boronophenylalanine is presented, results of 21 spontaneous-tumor-bearing dogs that have been treated with BNCT at the Brookhaven National Laboratory (BNL) Medical Research Reactor (BMRR) are discussed, and predictions for an epithermal-neutron beam at the Georgia Tech Research Reactor (GTRR) are shown. Cellular-level boron detection and localization by secondary ion mass spectrometry, sputter-initiated resonance ionization spectroscopy, low atomization resonance ionization spectroscopy, and alpha track are presented. Boron detection by ICP-AES is discussed in detail. Several boron carrying drugs exhibiting good tumor uptake are described. Significant progress in the potential of treating pituitary tumors with BNCT is presented. Measurement of the epithermal-neutron flux at BNL and comparison to predictions are shown. Calculations comparing the GTRR and BMRR epithermal-neutron beams are also presented. Individual progress reports described herein are separately abstracted and indexed for the database

  18. CGH U.S.-China Program for Biomedical Research Cooperation

    Science.gov (United States)

    The International Bilateral Programs for Collaborative Scientific Research seeks to enhance the global activities of NCI’s intramural researchers and grantees through co-funded support for collaborative research between NIH and international scientific research agencies.

  19. Portfolio optimization by using linear programing models based on genetic algorithm

    Science.gov (United States)

    Sukono; Hidayat, Y.; Lesmana, E.; Putra, A. S.; Napitupulu, H.; Supian, S.

    2018-01-01

    In this paper, we discussed the investment portfolio optimization using linear programming model based on genetic algorithms. It is assumed that the portfolio risk is measured by absolute standard deviation, and each investor has a risk tolerance on the investment portfolio. To complete the investment portfolio optimization problem, the issue is arranged into a linear programming model. Furthermore, determination of the optimum solution for linear programming is done by using a genetic algorithm. As a numerical illustration, we analyze some of the stocks traded on the capital market in Indonesia. Based on the analysis, it is shown that the portfolio optimization performed by genetic algorithm approach produces more optimal efficient portfolio, compared to the portfolio optimization performed by a linear programming algorithm approach. Therefore, genetic algorithms can be considered as an alternative on determining the investment portfolio optimization, particularly using linear programming models.

  20. Army Medical Research and Materiel Command Resident Research Associateship Program

    Science.gov (United States)

    2017-05-01

    submitted four papers related to sleep and performance/sleep resiliency and genetics (2 published; 2 under review): Journal of Strength & Conditioning...study looking at genetic markers related to sleep resiliency and performance and performance maintenance with caffeine administration. This study is...muscle clock, Biochimie; 132:161-165 Brager, AJ; Hammer SB; Capaldi V; Campbell B, 2017, In search of adaptive homeostasis in ultra-marathon runners

  1. INEL BNCT Research Program annual report 1994

    Energy Technology Data Exchange (ETDEWEB)

    Venhuizen, J.R. [ed.

    1995-11-01

    This report is a summary of the progress and research produced for the Idaho National Engineering Laboratory (INEL) Boron Neutron Capture Therapy (BNCT) Research Program for calendar year 1994. Contributions from the principal investigators about their individual projects are included, specifically, chemistry (pituitary tumor studies, boron drug development including liposomes, lipoproteins, and carboranylalanine derivatives), pharmacology (murine screenings, toxicity testing, ICP-AES analysis of biological samples), physics (treatment planning software, neutron beam and filter design, neutron beam measurement dosimetry), and radiation biology (small and large animal models tissue studies and efficacy studies). Information on the potential toxicity of BSH and BPA is presented and results of 21 spontaneous tumor bearing dogs that have been treated with BNCT at Brookhaven National Laboratory (BNL) are discussed. Several boron carrying drugs exhibiting good tumor uptake are described. Significant progress in the potential of treating pituitary tumors is presented. Highlights from the First International Workshop on Accelerator-Based Neutron Sources for BNCT are included. Selected papers have been indexed separately for inclusion in the Energy Science and Technology Database.

  2. INEL BNCT Research Program Annual Report 1993

    Energy Technology Data Exchange (ETDEWEB)

    Venhuizen, J.R.

    1994-08-01

    This report is a summary of the progress and research produced for the Idaho National Engineering Laboratory Boron Neutron Capture Therapy Research Program for calendar year 1993. Contributions from all the principal investigators are included, covering chemistry (pituitary tumor studies, boron drug development including liposomes, lipoproteins, and carboranylalanine derivatives), pharmacology (murine screenings, toxicity testing, boron drug analysis), physics (radiation dosimetry software, neutron beam and filter design, neutron beam measurement dosimetry), and radiation biology (tissue and efficacy studies of small and large animal models). Information on the potential toxicity of borocaptate sodium and boronophenylalanine is presented. Results of 21 spontaneous-tumor-bearing dogs that have been treated with boron neutron capture therapy at the Brookhaven National Laboratory are updated. Boron-containing drug purity verification is discussed in some detail. Advances in magnetic resonance imaging of boron in vivo are discussed. Several boron-carrying drugs exhibiting good tumor uptake are described. Significant progress in the potential of treating pituitary tumors is presented. Measurement of the epithermal-neutron flux of the Petten (The Netherlands) High Flux Reactor beam (HFB11B), and comparison to predictions are shown.

  3. Medical Genetics at McGill: The History of a Pioneering Research Group.

    Science.gov (United States)

    Canning, Christopher; Weisz, George; Tone, Andrea; Cambrosio, Alberto

    2013-01-01

    The McGill Group in Medical Genetics was formed in 1972, supported by the Medical Research Council and successor Canadian Institutes for Health Research until September 2009, making it the longest active biomedical research group in the history of Canada. We document the history of the McGill Group and situate its research within a broader history of medical genetics. Drawing on original oral histories with the Group's members, surviving documents, and archival materials, we explore how the Group's development was structured around epistemological trends in medical genetics, policy choices made by research agencies, and the development of genetics at McGill University and its hospitals.

  4. A Survey of Campus Coordinators of Undergraduate Research Programs

    Science.gov (United States)

    Hensley, Merinda Kaye; Shreeves, Sarah L.; Davis-Kahl, Stephanie

    2015-01-01

    Interest in supporting undergraduate research programs continues to grow within academic librarianship. This article presents how undergraduate research program coordinators perceive and value library support of their programs. Undergraduate research coordinators from a variety of institutions were surveyed on which elements of libraries and…

  5. Multidisciplinary research program directed toward utilization of solar energy through bioconversion of renewable resources. Progress report

    Energy Technology Data Exchange (ETDEWEB)

    Finnerty, W. R.

    1976-07-01

    Progress is reported in four research areas of solar bioconversion. The first program deals with the genetic selection of superior trees, physiological basis of vigor, tissue culture, haploid cell lines, and somatic hybridization. The second deals with the physiology of paraquat-induced oleoresin biogenesis. Separate abstracts were prepared for the other two program areas: biochemical basis of paraquat-induced oleoresin production in pines and biochemistry of methanogenesis. (JSR)

  6. Research on numerical method for multiple pollution source discharge and optimal reduction program

    Science.gov (United States)

    Li, Mingchang; Dai, Mingxin; Zhou, Bin; Zou, Bin

    2018-03-01

    In this paper, the optimal method for reduction program is proposed by the nonlinear optimal algorithms named that genetic algorithm. The four main rivers in Jiangsu province, China are selected for reducing the environmental pollution in nearshore district. Dissolved inorganic nitrogen (DIN) is studied as the only pollutant. The environmental status and standard in the nearshore district is used to reduce the discharge of multiple river pollutant. The research results of reduction program are the basis of marine environmental management.

  7. An Exploration of Attitudes Among Black Americans Towards Psychiatric Genetic Research

    Science.gov (United States)

    Murphy, Eleanor; Thompson, Azure

    2011-01-01

    With increasing emphasis on understanding genetic contribution to disease, inclusion of all racial and ethnic groups in molecular genetic research is necessary to ensure parity in distribution of research benefits. Blacks are underrepresented in large-scale genetic studies of psychiatric disorders. In an effort to understand the reasons for the underrepresentation, this study explored black participants’ attitudes towards genetic research of psychiatric disorders. Twenty-six adults, the majority of whom were black (n = 18) were recruited from a New York City community to participate in six 90-minute focus groups. This paper reports findings about respondents’ understanding of genetics and genetic research, and opinions about psychiatric genetic research. Primary themes revealed participants’ perceived lack of knowledge about genetics, concerns about potentially harmful study procedures, and confidentiality surrounding mental illness in families. Participation incentives included provision of treatment or related service, monetary compensation, and reporting of results to participants. These findings suggest that recruitment of subjects into genetic studies should directly address procedures, privacy, benefits and follow-up with results. Further, there is critical need to engage communities with education about genetics and mental illness, and provide opportunities for continued discussion about concerns related to genetic research. PMID:19614555

  8. P and T research program in Korea

    International Nuclear Information System (INIS)

    Park, C. K.

    1997-01-01

    The national energy demand is taking a sharp rise on account of the rapid growth of economy in Korea. Unfortunately, Korea has not much choice of alternative energy a promising option for Korea. For instance, eleven nuclear plants are in operation and 7 plants are under construction. Several plants are in planning stage. KAERI has played a major role in the design and operation of the plants in Korea. The spent fuel issue is calling for acute attention nationwide as the number of plants increases. Korea is actively seeking a technical solution to that problem surfacing on the horizon. A preliminary conceptual study on the P and T technology was performed from 1992 to 1996 and the future research directions were derived from that study. Because of the situation Korea is facing with, one of the major technical guidelines is that the P and T technology should be developed in compliance with the NPT. The concept of an accelerator driven subcritical system was found to be the most favorable option according to the conceptual study. KAERI set up an ambitious accelerator driven system development program for next 10 years. Key elementary technologies for a high current accelerator and a subcritical system are scheduled to be developed and experimented for the first five years (1997-2001). For the second five years (2002-2006), the accelerator program is pushed for the completion to parameters of 1 GeV, 20mA with capability to drive a subcritical system. For the subcritical system, a detail design study is to be performed and a small mockup system is to be built for bench scale test purpose

  9. Building Technologies Program Multi-Year Program Plan Research and Development 2008

    Energy Technology Data Exchange (ETDEWEB)

    None, None

    2008-01-01

    Building Technologies Program Multi-Year Program Plan 2008 for research and development, including residential and commercial integration, lighting, HVAC and water heating, envelope, windows, and analysis tools.

  10. AECL research programs in life sciences

    International Nuclear Information System (INIS)

    Marko, A.M.

    1981-04-01

    The present report summarizes the current research activities in life sciences in the Atomic Energy of Canada Limited-Research Company. The research is carried out at its two main research sites: the Chalk River Nuclear Laboratories and the Whiteshell Nuclear Research Establishment. The summaries cover the following areas of research: radiation biology, medical biophysics, epidemiology, environmental research and dosimetry. (author)

  11. A Constraint programming-based genetic algorithm for capacity output optimization

    Directory of Open Access Journals (Sweden)

    Kate Ean Nee Goh

    2014-10-01

    Full Text Available Purpose: The manuscript presents an investigation into a constraint programming-based genetic algorithm for capacity output optimization in a back-end semiconductor manufacturing company.Design/methodology/approach: In the first stage, constraint programming defining the relationships between variables was formulated into the objective function. A genetic algorithm model was created in the second stage to optimize capacity output. Three demand scenarios were applied to test the robustness of the proposed algorithm.Findings: CPGA improved both the machine utilization and capacity output once the minimum requirements of a demand scenario were fulfilled. Capacity outputs of the three scenarios were improved by 157%, 7%, and 69%, respectively.Research limitations/implications: The work relates to aggregate planning of machine capacity in a single case study. The constraints and constructed scenarios were therefore industry-specific.Practical implications: Capacity planning in a semiconductor manufacturing facility need to consider multiple mutually influenced constraints in resource availability, process flow and product demand. The findings prove that CPGA is a practical and an efficient alternative to optimize the capacity output and to allow the company to review its capacity with quick feedback.Originality/value: The work integrates two contemporary computational methods for a real industry application conventionally reliant on human judgement.

  12. Programs and Research Advisor | IDRC - International Development ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Support risk management of regional programming and partnerships by: ... analysing, on a regular basis, key program development and performance indicators; ... Represent the IDRC and Regional Director at key events in order to gather ...

  13. FY 1995 research highlights: PNL accomplishments in OER programs

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-10-01

    Pacific Northwest Laboratory (PNL) conducts fundamental and applied research in support of the US Department of Energy`s (DOE) core missions in science and technology, environmental quality, energy resources, and national security. Much of this research is funded by the program offices of DOE`s Office of Energy Research (DOE-ER), primarily the Office of Basic Energy Sciences (BES) and the Office of Health and Environmental Research (OHER), and by PNL`s Laboratory Directed Research and Development (LDRD) Program. This document is a collection of research highlights that describe PNL`s accomplishments in DOE-ER funded programs during Fiscal Year 1995. Included are accomplishments in research funded by OHER`s Analytical Technologies, Environmental Research, Health Effects, General Life Sciences, and Carbon Dioxide Research programs; BES`s Materials Science, Chemical Sciences, Engineering and Geoscience, and Applied Mathematical Sciences programs; and PNL`s LDRD Program. Summaries are given for 70 projects.

  14. Program Assistant | IDRC - International Development Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Job Summary Under the direction of the Program Leader, the Program ... of the operations of the Program, and assists with information management the team. ... and distribution of documents and providing the necessary technical devices;; Takes ... mailings or distribution;; Prepares training kits or information packages and ...

  15. Developing close combat behaviors for simulated soldiers using genetic programming techniques.

    Energy Technology Data Exchange (ETDEWEB)

    Pryor, Richard J.; Schaller, Mark J.

    2003-10-01

    Genetic programming is a powerful methodology for automatically producing solutions to problems in a variety of domains. It has been used successfully to develop behaviors for RoboCup soccer players and simple combat agents. We will attempt to use genetic programming to solve a problem in the domain of strategic combat, keeping in mind the end goal of developing sophisticated behaviors for compound defense and infiltration. The simplified problem at hand is that of two armed agents in a small room, containing obstacles, fighting against each other for survival. The base case and three changes are considered: a memory of positions using stacks, context-dependent genetic programming, and strongly typed genetic programming. Our work demonstrates slight improvements from the first two techniques, and no significant improvement from the last.

  16. A Genetic-Algorithms-Based Approach for Programming Linear and Quadratic Optimization Problems with Uncertainty

    Directory of Open Access Journals (Sweden)

    Weihua Jin

    2013-01-01

    Full Text Available This paper proposes a genetic-algorithms-based approach as an all-purpose problem-solving method for operation programming problems under uncertainty. The proposed method was applied for management of a municipal solid waste treatment system. Compared to the traditional interactive binary analysis, this approach has fewer limitations and is able to reduce the complexity in solving the inexact linear programming problems and inexact quadratic programming problems. The implementation of this approach was performed using the Genetic Algorithm Solver of MATLAB (trademark of MathWorks. The paper explains the genetic-algorithms-based method and presents details on the computation procedures for each type of inexact operation programming problems. A comparison of the results generated by the proposed method based on genetic algorithms with those produced by the traditional interactive binary analysis method is also presented.

  17. Nuclear Plant Aging Research (NPAR) program plan

    International Nuclear Information System (INIS)

    1985-07-01

    The nuclear plant aging research described in this plan is intended to resolve issues related to the aging and service wear of equipment and systems at commercial reactor facilities and their possible impact on plant safety. Emphasis has been placed on identification and characterization of the mechansims of material and component degradation during service and evaluation of methods of inspection, surveillance, condition monitoring and maintenance as means of mitigating such effects. Specifically the goals of the program are as follows: (1) to identify and characterize aging and service wear effects which, if unchecked, could cause degradation of structures, components, and systems and thereby impair plant safety; (2) to identify methods of inspection, surveillance and monitoring, or of evaluating residual life of structures, components, and systems, which will assure timely detection of significant aging effects prior to loss of safety function; and (3) to evaluate the effectiveness of storage, maintenance, repair and replacement practices in mitigating the rate and extent of degradation caused by aging and service wear

  18. Genetics of Post-Traumatic Stress Disorder: Informing Clinical Conceptualizations and Promoting Future Research

    Science.gov (United States)

    Nugent, Nicole R.; Amstadter, Ananda B.; Koenen, Karestan C.

    2009-01-01

    The purpose of this article is to provide an overview of genetic research involving post-traumatic stress disorder (PTSD). First, we summarize evidence for genetic influences on PTSD from family investigations. Second, we discuss the distinct contributions to our understanding of the genetics of PTSD permitted by twin studies. Finally, we summarize findings from molecular genetic studies, which have the potential to inform our understanding of underlying biological mechanisms for the development of PTSD. PMID:18412098

  19. DECONTAMINATION SYSTEMS AND INFORMATION RESEARCH PROGRAM; FINAL

    International Nuclear Information System (INIS)

    Echol E. Cook, Ph.D., PE.

    1998-01-01

    During the five plus years this Cooperative Agreement existed, more than 45 different projects were funded. Most projects were funded for a one year period but there were some, deemed of such quality and importance, funded for multiple years. Approximately 22 external agencies, businesses, and other entities have cooperated with or been funded through the WVU Cooperative Agreement over the five plus years. These external entities received 33% of the funding by this Agreement. The scope of this Agreement encompassed all forms of hazardous waste remediation including radioactive, organic, and inorganic contaminants. All matrices were of interest; generally soil, water, and contaminated structures. Economic, health, and regulatory aspects of technologies were also within the scope of the agreement. The highest priority was given to small businesses funded by the Federal Energy Technology Center (FETC) and Department of Energy (DOE) involved in research and development of innovative remediation processes. These projects were to assist in the removal of barriers to development and commercialization of these new technologies. Studies of existing, underdeveloped technologies, were preferred to fundamental research into remediation technologies. Sound development of completely new technologies was preferred to minor improvements in existing methods. Solid technological improvements in existing technologies or significant cost reduction through innovative redesign were the preferred projects. Development, evaluation, and bench scale testing projects were preferred for the WVU research component. In the effort to fill gaps in current remediation technologies, the worth of the WVU Cooperative Agreement was proven. Two great technologies came out of the program. The Prefabricated Vertical Drain Technology for enhancing soil flushing was developed over the 6-year period and is presently being demonstrated on a 0.10 acre Trichloroethylene contaminated site in Ohio. The Spin

  20. Role of EPA in Asset Management Research – The Aging Water Infrastructure Research Program

    Science.gov (United States)

    This slide presentation provides an overview of the EPA Office of Research and Development’s Aging Water infrastructure Research Program (AWIRP). The research program origins, goals, products, and plans are described. The research program focuses on four areas: condition asses...

  1. Insect-resistant genetically modified rice in China: from research to commercialization.

    Science.gov (United States)

    Chen, Mao; Shelton, Anthony; Ye, Gong-yin

    2011-01-01

    From the first insect-resistant genetically modified (IRGM) rice transformation in 1989 in China to October 2009 when the Chinese Ministry of Agriculture issued biosafety certificates for commercial production of two cry1Ab/Ac Bacillus thuringiensis (Bt) lines, China made a great leap forward from IRGM rice basic research to potential commercialization of the world's first IRGM rice. Research has been conducted on developing IRGM rice, assessing its environmental and food safety impacts, and evaluating its socioeconomic consequences. Laboratory and field tests have confirmed that these two Bt rice lines can provide effective and economic control of the lepidopteran complex on rice with less risk to the environment than present practices. Commercializing these Bt plants, while developing other GM plants that address the broader complex of insects and other pests, will need to be done within a comprehensive integrated pest management program to ensure the food security of China and the world.

  2. Environmental Biotechnology Research and Development Program 1989-1992

    OpenAIRE

    Brinkman J; Rulkens WH; Visscher K

    1989-01-01

    This report is an English translation of the Dutch Research and Development Program on environmental biotechnology 1989-1992. In this program an overview is given of the recent developments in environmental biotechnology. Based on this overview, the possibilities of biotechnology for management of the environment are evaluated. In this program two kinds of research are distinguished. Applied research directly focusses on specific environmental problems. Fundamental research aims at developing...

  3. Programs director's report for the Office of Health and Environmental Research

    International Nuclear Information System (INIS)

    1996-08-01

    Since its establishment, the Department of Energy's Office of Health and Environmental Research (OHER) has had responsibility for conducting biological research to develop the knowledge needed to identify, understand, and anticipate the long-term health consequences of energy use and development, including the potential health impacts of radiation. The Health Effects Research Program has established the basis for understanding the health consequences of radiation for humans, developed radiation dosimetry methodology, characterized and evaluated the health impacts of fossil fuels, and developed and conducted research to determine the health impacts of inhaled toxicants. The results of this research have provided input for setting genetic standards for radiation and chemical exposure

  4. Programs director`s report for the Office of Health and Environmental Research

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-08-01

    Since its establishment, the Department of Energy`s Office of Health and Environmental Research (OHER) has had responsibility for conducting biological research to develop the knowledge needed to identify, understand, and anticipate the long-term health consequences of energy use and development, including the potential health impacts of radiation. The Health Effects Research Program has established the basis for understanding the health consequences of radiation for humans, developed radiation dosimetry methodology, characterized and evaluated the health impacts of fossil fuels, and developed and conducted research to determine the health impacts of inhaled toxicants. The results of this research have provided input for setting genetic standards for radiation and chemical exposure.

  5. Program of Research and Education in Aerospace Structures

    Science.gov (United States)

    Whitesides, John L.; Johansen, Laurie W.

    2005-01-01

    Since its inception in January 2003, the program has provided support for 1 research professor and a total of 10 Graduate Research Scholar Assistants of these all 10 have completed their MS degree program. The program has generated 10 MS thesis. Final report lists papers presented in seminars for the period January 1, 2003 through June 30, 2005.

  6. 77 FR 46805 - Small Business Innovation Research Program Policy Directive

    Science.gov (United States)

    2012-08-06

    ... Vol. 77 Monday, No. 151 August 6, 2012 Part II Small Business Administration 13 CFR Chapter I Small Business Innovation Research Program Policy Directive; Small Business Technology Transfer Program Policy Directive; Small Business Innovation Research (SBIR) Program and Small Business Technology...

  7. Evaluation of a Research Mentorship Program in Community Care

    Science.gov (United States)

    Ploeg, Jenny; de Witt, Lorna; Hutchison, Brian; Hayward, Lynda; Grayson, Kim

    2008-01-01

    This article describes the results of a qualitative case study evaluating a research mentorship program in community care settings in Ontario, Canada. The purpose of the program was to build evaluation and research capacity among staff of community care agencies through a mentorship program. Data were collected through in-depth, semi-structured…

  8. Research of the Rio Grande Ecosystem Management Program

    Science.gov (United States)

    Deborah M. Finch

    2000-01-01

    This paper describes the mission, objectives, and preliminary results of the Middle Rio Grande Ecosystem Management Research Program managed at the Rocky Mountain Research Station's Albuquerque laboratory. This program was initiated in 1994 to address growing pressures to effectively manage the limited resources of the middle Rio Grande Basin. The program is...

  9. Fusion Research Center, theory program. Progress report

    International Nuclear Information System (INIS)

    1982-01-01

    The Texas FRC theory program is directed primarily toward understanding the initiation, heating, and confinement of tokamak plasmas. It supports and complements the experimental programs on the TEXT and PRETEXT devices, as well as providing information generally applicable to the national tokamak program. A significant fraction of the Center's work has been carried out in collaboration with, or as a part of, the program of the Institute for Fusion Studies (IFS). During the past twelve months, 14 FRC theory reports and 12 IFS reports with partial FRC support have been issued

  10. Estimation of genetic parameters for growth traits in a breeding program for rainbow trout (Oncorhynchus mykiss) in China.

    Science.gov (United States)

    Hu, G; Gu, W; Bai, Q L; Wang, B Q

    2013-04-26

    Genetic parameters and breeding values for growth traits were estimated in the first and, currently, the only family selective breeding program for rainbow trout (Oncorhynchus mykiss) in China. Genetic and phenotypic data were collected for growth traits from 75 full-sibling families with a 2-generation pedigree. Genetic parameters and breeding values for growth traits of rainbow trout were estimated using the derivative-free restricted maximum likelihood method. The goodness-of-fit of the models was tested using Akaike and Bayesian information criteria. Genetic parameters and breeding values were estimated using the best-fit model for each trait. The values for heritability estimating body weight and length ranged from 0.20 to 0.45 and from 0.27 to 0.60, respectively, and the heritability of condition factor was 0.34. Our results showed a moderate degree of heritability for growth traits in this breeding program and suggested that the genetic and phenotypic tendency of body length, body weight, and condition factor were similar. Therefore, the selection of phenotypic values based on pedigree information was also suitable in this research population.

  11. Review: fetal programming of polycystic ovary syndrome by androgen excess: evidence from experimental, clinical, and genetic association studies.

    Science.gov (United States)

    Xita, Nectaria; Tsatsoulis, Agathocles

    2006-05-01

    Polycystic ovary syndrome (PCOS) is a common endocrine disorder of premenopausal women, characterized by hyperandrogenism, polycystic ovaries, and chronic anovulation along with insulin resistance and abdominal obesity as frequent metabolic traits. Although PCOS manifests clinically during adolescence, emerging data suggest that the natural history of PCOS may originate in intrauterine life. Evidence from experimental, clinical, and genetic research supporting the hypothesis for the fetal origins of PCOS has been analyzed. Female primates, exposed in utero to androgen excess, exhibit the phenotypic features of PCOS during adult life. Clinical observations also support a potential fetal origin of PCOS. Women with fetal androgen excess disorders, including congenital 21-hydroxylase deficiency and congenital adrenal virilizing tumors, develop features characteristic of PCOS during adulthood despite the normalization of androgen excess after birth. The potential mechanisms of fetal androgen excess leading to a PCOS phenotype in humans are not clearly understood. However, maternal and/or fetal hyperandrogenism can provide a plausible mechanism for fetal programing of PCOS, and this, in part, may be genetically determined. Thus, genetic association studies have indicated that common polymorphic variants of genes determining androgen activity or genes that influence the availability of androgens to target tissues are associated with PCOS and increased androgen levels. These genomic variants may provide the genetic link to prenatal androgenization in human PCOS. Prenatal androgenization of the female fetus induced by genetic and environmental factors, or the interaction of both, may program differentiating target tissues toward the development of PCOS phenotype in adult life.

  12. Examining Burma's Development: A Research Fellowship Program ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    The Regional Center for Social Science and Sustainable Development (RCSD) at Thailand's Chiang Mai University will manage the four-year program, which targets junior and mid-level academic and non-academic Burmese scholars. The program will ... LVIF announces five more funded projects. Eleven world-class ...

  13. Pacific Northwest Laboratory Alaska (ARCTIC) research program

    International Nuclear Information System (INIS)

    Hanson, W.C.; Eberhardt, L.E.

    1980-03-01

    The current program continues studies of arctic ecosystems begun in 1959 as part of the Cape Thompson Program. Specific ecosystem aspects include studies of the ecology of arctic and red foxes, small mammel and bird population studies, lichen studies, and radiation ecology studies

  14. GSI research and development program 1989

    International Nuclear Information System (INIS)

    1989-01-01

    In the year 1989 the SIS will come into operation and the erection of the ESR will be finished. The construction of a new uranium injector for an independent low-energy program at UNILAC has begun. Furthermore the UNILAC is available for the SIS injection and an experimental low-energy program confined by this. (orig./HSI) [de

  15. Aquaculture-oriented genetic researches in abalone: Current status ...

    African Journals Online (AJOL)

    Taghwo

    2013-06-26

    Jun 26, 2013 ... Basic genetic and cytogenetic information including polymorphic DNA markers, chromosomes and genome size was ..... Stepto and Cook(1998). H. asinina ... quantity of fertilized eggs and very expensive “French. Press” is ...

  16. Disclosure of genetics research results after the death of the patient participant: a qualitative study of the impact on relatives.

    Science.gov (United States)

    Ormondroyd, E; Moynihan, C; Watson, M; Foster, C; Davolls, S; Ardern-Jones, A; Eeles, R

    2007-08-01

    When a gene mutation is identified in a research study following the death of the study participant, it is not clear whether such information should be made available to relatives. We report here an evaluation of the impact on relatives of being informed of study results that detected pathogenic BRCA2 mutations in a male relative, now deceased, who had early onset (under the age of 55) prostate cancer. The breast and ovarian cancer risk was unknown to the living relatives. Qualitative analysis of interviews with thirteen relatives indicated that those who had a higher risk perception, resulting from an awareness of cancer family history or experiential knowledge of cancer in their family, tended to adjust more easily to the results. All participants believed that genetics research results of clinical significance should be fed back to relatives. Those who were fully aware of the BRCA2 results and implications for themselves felt they had benefited from the information, irrespective of whether or not they had elected for genetic testing, because of the consequent availability of surveillance programs. Initial anxiety upon learning about the BRCA2 result was alleviated by genetic counselling. Factors influencing those who have not engaged with the information included scepticism related to the relative who attempted to inform them, young age and fear of cancer. Those who had not sought genetic counselling did not attempt further dissemination, and some were not undergoing regular screening. Implications for informed consent in genetics research programs, and the requirement for genetic counselling when research results are disclosed, are discussed.

  17. Using Fuzzy Gaussian Inference and Genetic Programming to Classify 3D Human Motions

    Science.gov (United States)

    Khoury, Mehdi; Liu, Honghai

    This research introduces and builds on the concept of Fuzzy Gaussian Inference (FGI) (Khoury and Liu in Proceedings of UKCI, 2008 and IEEE Workshop on Robotic Intelligence in Informationally Structured Space (RiiSS 2009), 2009) as a novel way to build Fuzzy Membership Functions that map to hidden Probability Distributions underlying human motions. This method is now combined with a Genetic Programming Fuzzy rule-based system in order to classify boxing moves from natural human Motion Capture data. In this experiment, FGI alone is able to recognise seven different boxing stances simultaneously with an accuracy superior to a GMM-based classifier. Results seem to indicate that adding an evolutionary Fuzzy Inference Engine on top of FGI improves the accuracy of the classifier in a consistent way.

  18. LPmerge: an R package for merging genetic maps by linear programming.

    Science.gov (United States)

    Endelman, Jeffrey B; Plomion, Christophe

    2014-06-01

    Consensus genetic maps constructed from multiple populations are an important resource for both basic and applied research, including genome-wide association analysis, genome sequence assembly and studies of evolution. The LPmerge software uses linear programming to efficiently minimize the mean absolute error between the consensus map and the linkage maps from each population. This minimization is performed subject to linear inequality constraints that ensure the ordering of the markers in the linkage maps is preserved. When marker order is inconsistent between linkage maps, a minimum set of ordinal constraints is deleted to resolve the conflicts. LPmerge is on CRAN at http://cran.r-project.org/web/packages/LPmerge. © The Author 2014. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

  19. Surrogate-Assisted Genetic Programming With Simplified Models for Automated Design of Dispatching Rules.

    Science.gov (United States)

    Nguyen, Su; Zhang, Mengjie; Tan, Kay Chen

    2017-09-01

    Automated design of dispatching rules for production systems has been an interesting research topic over the last several years. Machine learning, especially genetic programming (GP), has been a powerful approach to dealing with this design problem. However, intensive computational requirements, accuracy and interpretability are still its limitations. This paper aims at developing a new surrogate assisted GP to help improving the quality of the evolved rules without significant computational costs. The experiments have verified the effectiveness and efficiency of the proposed algorithms as compared to those in the literature. Furthermore, new simplification and visualisation approaches have also been developed to improve the interpretability of the evolved rules. These approaches have shown great potentials and proved to be a critical part of the automated design system.

  20. The United States Advanced Reactor Technologies Research and Development Program

    International Nuclear Information System (INIS)

    O’Connor, Thomas J.

    2014-01-01

    The following aspects are addressed: • Nuclear energy mission; • Reactor research development and deployment (RD&D) programs: - Light Water Reactor Sustainability Program; - Small Modular Reactor Licensing Technical Support; - Advanced Reactor Technologies (ART)

  1. Training Program in Biostatistics for Breast Cancer Research

    National Research Council Canada - National Science Library

    Little, Roderick

    1998-01-01

    The current training program terminates in the summer of 1998. We had originally planned to develop a training program in biostatistics for cancer research for submission to the National Cancer Institute (Task 9...

  2. Idaho Transportation Department : 2010 research program peer exchange.

    Science.gov (United States)

    2010-05-01

    The objectives of the peer exchange were to: : 1. Identify strengths, challenges, and opportunities for program and project management; : 2. Understand management expectations of the ITD Research Program; : 3. Review processes for project selection a...

  3. Genetic counseling for schizophrenia: a review of referrals to a provincial medical genetics program from 1968–2007

    Science.gov (United States)

    Hunter, MJ; Hippman, Catriona; Honer, William G; Austin, Jehannine C.

    2014-01-01

    Purpose Recent studies have shown that individuals with schizophrenia and their family members are interested in genetic counseling, but few have received this service. We conducted an exploratory, retrospective study to describe (a) the population of individuals who were referred to the provincial program for genetic counseling for a primary indication of schizophrenia, and (b) trends in number of referrals between 1968 and 2007. Methods Referrals for a primary indication of schizophrenia were identified through the provincial program database. Charts were reviewed and the following information was recorded: discipline of referring physician, demographics, psychiatric diagnosis, referred individual’s and partner’s (if applicable) family history, and any current pregnancy history. Data were characterized using descriptive statistics. Results Between 1968 and 2007, 288 referrals were made for a primary indication of schizophrenia. Most referrals were made: (a) for individuals who had a first-degree family member with schizophrenia, rather than for affected individuals, (b) for preconception counseling, and (c) by family physicians (69%), with only 2% by psychiatrists. Conclusions In British Columbia, individuals affected with schizophrenia and their family members are rarely referred for psychiatric genetic counseling. There is a need to identify barriers to psychiatric genetic counseling and develop strategies to improve access. PMID:20034078

  4. Situated Research Design and Methodological Choices in Formative Program Evaluation

    Science.gov (United States)

    Supovitz, Jonathan

    2013-01-01

    Design-based implementation research offers the opportunity to rethink the relationships between intervention, research, and situation to better attune research and evaluation to the program development process. Using a heuristic called the intervention development curve, I describe the rough trajectory that programs typically follow as they…

  5. 76 FR 11765 - Education Research and Special Education Research Grant Programs; Institute of Education Sciences...

    Science.gov (United States)

    2011-03-03

    ... DEPARTMENT OF EDUCATION Education Research and Special Education Research Grant Programs; Institute of Education Sciences; Overview Information; Education Research and Special Education Research.... SUMMARY: The Director of the Institute of Education Sciences (Institute) announces the Institute's FY 2012...

  6. Overview of EPRI's human factors research program

    International Nuclear Information System (INIS)

    O'Brien, J.F.; Parris, H.L.

    1981-01-01

    The human factors engineering program in the Nuclear Power Division, EPRI is dedicated to the resolution of man-machine interface problems specific to the nuclear power industry. Particularly emphasis is placed on the capabilities and limitations of the people who operate and maintain the system, the tasks they must perform, and what they need to accomplish those tasks. Six human factors R and D projects are being conducted at the present time. In addition, technical consultation is being furnished to a study area, operator aids, being funded by another program area outside the human factors program area. All of these activities are summarized

  7. Public and biobank participant attitudes toward genetic research participation and data sharing.

    Science.gov (United States)

    Lemke, A A; Wolf, W A; Hebert-Beirne, J; Smith, M E

    2010-01-01

    Research assessing attitudes toward consent processes for high-throughput genomic-wide technologies and widespread sharing of data is limited. In order to develop a better understanding of stakeholder views toward these issues, this cross-sectional study assessed public and biorepository participant attitudes toward research participation and sharing of genetic research data. Forty-nine individuals participated in 6 focus groups; 28 in 3 public focus groups and 21 in 3 NUgene biorepository participant focus groups. In the public focus groups, 75% of participants were women, 75% had some college education or more, 46% were African-American and 29% were Hispanic. In the NUgene focus groups, 67% of participants were women, 95% had some college education or more, and the majority (76%) of participants was Caucasian. Five major themes were identified in the focus group data: (a) a wide spectrum of understanding of genetic research; (b) pros and cons of participation in genetic research; (c) influence of credibility and trust of the research institution; (d) concerns about sharing genetic research data and need for transparency in the Policy for Sharing of Data in National Institutes of Health-Supported or Conducted Genome-Wide Association Studies; (e) a need for more information and education about genetic research. In order to increase public understanding and address potential concerns about genetic research, future efforts should be aimed at involving the public in genetic research policy development and in identifying or developing appropriate educational strategies to meet the public's needs.

  8. A comparison of fitness-case sampling methods for genetic programming

    Science.gov (United States)

    Martínez, Yuliana; Naredo, Enrique; Trujillo, Leonardo; Legrand, Pierrick; López, Uriel

    2017-11-01

    Genetic programming (GP) is an evolutionary computation paradigm for automatic program induction. GP has produced impressive results but it still needs to overcome some practical limitations, particularly its high computational cost, overfitting and excessive code growth. Recently, many researchers have proposed fitness-case sampling methods to overcome some of these problems, with mixed results in several limited tests. This paper presents an extensive comparative study of four fitness-case sampling methods, namely: Interleaved Sampling, Random Interleaved Sampling, Lexicase Selection and Keep-Worst Interleaved Sampling. The algorithms are compared on 11 symbolic regression problems and 11 supervised classification problems, using 10 synthetic benchmarks and 12 real-world data-sets. They are evaluated based on test performance, overfitting and average program size, comparing them with a standard GP search. Comparisons are carried out using non-parametric multigroup tests and post hoc pairwise statistical tests. The experimental results suggest that fitness-case sampling methods are particularly useful for difficult real-world symbolic regression problems, improving performance, reducing overfitting and limiting code growth. On the other hand, it seems that fitness-case sampling cannot improve upon GP performance when considering supervised binary classification.

  9. Horonobe underground research program. Research report of 2002 FY investigation

    International Nuclear Information System (INIS)

    2003-06-01

    Main results of investigation about Horonobe deep underground research center in 2002 FY were reported. It consists of six chapters: introduction, main results, selection of research center area, underground science research, R and D of geological disposal, and the environmental survey and research center on the ground. The research center area at about 3 km north of Horonobe (B1) was selected in the four areas: A, B1, B2 and C on the basis of data, researches in the sky, aboveground and underground and other conditions. The model of geological environment was constructed by physical, geological, surface water supply researches. Development of geological environment monitoring techniques, investigation of long stabilization of geological environment and design of underground facilities are reported. The basic design of preparation of research center was investigated. (S.Y.)

  10. Programs | IDRC - International Development Research Centre

    International Development Research Centre (IDRC) Digital Library (Canada)

    Our development programs support innovative solutions that improve global ... Chestnut farm worker carries basket of harvest chestnuts on shoulders in China ... Invest in knowledge and innovation for large-scale positive change; Build the ...

  11. Nuclear plant aging research program activities

    International Nuclear Information System (INIS)

    Eissenberg, D.M.

    1986-01-01

    The objective of this program is to provide recommendations for use by NRC regarding the availability and capability of diagnostic methods for assuring the operational readiness of NPP safety systems and components

  12. Federal Geothermal Research Program Update - Fiscal Year 2001

    Energy Technology Data Exchange (ETDEWEB)

    Laney, P.T.

    2002-08-31

    This Federal Geothermal Program Research Update reviews the specific objectives, status, and accomplishments of DOE's Geothermal Program for Federal Fiscal Year (FY) 2001. The information contained in this Research Update illustrates how the mission and goals of the Office of Geothermal Technologies are reflected in each R&D activity. The Geothermal Program, from its guiding principles to the most detailed research activities, is focused on expanding the use of geothermal energy.

  13. Karlsruhe Nuclear Research Center. Research and development program 1991

    International Nuclear Information System (INIS)

    1990-01-01

    The R and D activities of the KfK are classified in 8 main research activities: 1) project nuclear fusion; 2) project pollutant mitigation in the environment; 3) solid state and materials research; 4) nuclear and elementary particle physics; 5) microtechnics e.g. X-ray lithography; 6) materials handling; 7) project nuclear safety research; 8) radioactive waste management. (orig.) [de

  14. Artificial intelligence programming with LabVIEW: genetic algorithms for instrumentation control and optimization.

    Science.gov (United States)

    Moore, J H

    1995-06-01

    A genetic algorithm for instrumentation control and optimization was developed using the LabVIEW graphical programming environment. The usefulness of this methodology for the optimization of a closed loop control instrument is demonstrated with minimal complexity and the programming is presented in detail to facilitate its adaptation to other LabVIEW applications. Closed loop control instruments have variety of applications in the biomedical sciences including the regulation of physiological processes such as blood pressure. The program presented here should provide a useful starting point for those wishing to incorporate genetic algorithm approaches to LabVIEW mediated optimization of closed loop control instruments.

  15. About the Epidemiology and Genomics Research Program

    Science.gov (United States)

    Epidemiology is the scientific study of the causes and distribution of disease in populations. NCI-funded epidemiology research is conducted through research at institutions in the United States and internationally.

  16. Research Award: Innovation for Inclusive Development program

    International Development Research Centre (IDRC) Digital Library (Canada)

    IDRC CRDI

    2011-09-12

    Sep 12, 2011 ... students, as well as recent graduates, to enhance their research skills ... experience in development research. ... enable greater understanding of how innovation in the informal ... Innovation and women in the informal sector.

  17. Routine human-competitive machine intelligence by means of genetic programming

    Science.gov (United States)

    Koza, John R.; Streeter, Matthew J.; Keane, Martin

    2004-01-01

    Genetic programming is a systematic method for getting computers to automatically solve a problem. Genetic programming starts from a high-level statement of what needs to be done and automatically creates a computer program to solve the problem. The paper demonstrates that genetic programming (1) now routinely delivers high-return human-competitive machine intelligence; (2) is an automated invention machine; (3) can automatically create a general solution to a problem in the form of a parameterized topology; and (4) has delivered a progression of qualitatively more substantial results in synchrony with five approximately order-of-magnitude increases in the expenditure of computer time. Recent results involving the automatic synthesis of the topology and sizing of analog electrical circuits and controllers demonstrate these points.

  18. Fusion Energy Postdoctoral Research Program, Professional Development Program: FY 1987 annual report

    International Nuclear Information System (INIS)

    1988-01-01

    In FY 1986, Oak Ridge Associated Universities (ORAU) initiated two programs for the US Department of Energy (DOE), Office of Fusion Energy (OFE): the Fusion Energy Postdoctoral Research Program and the Fusion Energy Professional Development Program. These programs provide opportunities to conduct collaborative research in magnetic fusion energy research and development programs at DOE laboratories and contractor sites. Participants become trained in advanced fusion energy research, interact with outstanding professionals, and become familiar with energy-related national issues while making personal contributions to the search for solutions to scientific problems. Both programs enhance the national fusion energy research and development effort by providing channels for the exchange of scientists and engineers, the diffusion of ideas and knowledge, and the transfer of relevant technologies. These programs, along with the Magnetic Fusion Energy Science and Technology Fellowship Programs, compose the fusion energy manpower development programs administered by ORAU for DOE/OFE

  19. Advancing prion science: guidance for the National Prion Research Program

    National Research Council Canada - National Science Library

    Erdtmann, Rick; Sivitz, Laura

    2004-01-01

    ...€™s National Prion Research Program (NPRP). Transmissible spongiform encephalopathies (TSEs), also called prion diseases, are invariably fatal neurodegenerative infectious diseases that include bovine spongiform encephalopathy...

  20. Forschungszentrum Karlsruhe Technik und Umwelt. Research and development program 2002

    International Nuclear Information System (INIS)

    2001-01-01

    The five main fields of research and the activities under the R and D program 2002 are explained in great detail in five chapters with the following captions: 1. ENVIRONMENT. Programs: - Sustainable development, energy and environmental engineering (UMWELT). - Earth atmosphere and climate research (ATMO). 2. PUBLIC HEALTH. Programs: - Biomedical research (BIOMED). - Medical engineering (MEDTECH). 3. ENERGY. Programs: - Thermonuclear fusion (FUSION). - Nuclear safety (NUKLEAR). 4. KEY TECHNOLOGIES. Programs: - Microsystems engineering (MIKRO). - Nanotechnology (NANO). - Materials science (MATERIAL). - Chemical process engineering (CHEMIE). - Superconductivity (SUPRA). 5. MATTER and STRUCTURE. Program: The structure of matter (STRUKTUR). The sixth chapter presents cross-cutting activities under the program: Technology transfer and marketing (TTM). The concluding chapter lists and briefly presents the activities of the scientific and technical institutes of the Karlsruhe Research Center. (CB) [de

  1. Otolaryngology Residency Program Research Resources and Scholarly Productivity.

    Science.gov (United States)

    Villwock, Jennifer A; Hamill, Chelsea S; Nicholas, Brian D; Ryan, Jesse T

    2017-06-01

    Objective To delineate research resources available to otolaryngology residents and their impact on scholarly productivity. Study Design Survey of current otolaryngology program directors. Setting Otolaryngology residency programs. Subjects and Methods An anonymous web-based survey was sent to 98 allopathic otolaryngology training program directors. Fisher exact tests and nonparametric correlations were used to determine statistically significant differences among various strata of programs. Results Thirty-nine percent (n = 38) of queried programs responded. Fourteen (37%) programs had 11 to 15 full-time, academic faculty associated with the residency program. Twenty (53%) programs have a dedicated research coordinator. Basic science lab space and financial resources for statistical work were present at 22 programs (58%). Funding is uniformly provided for presentation of research at conferences; a minority of programs (13%) only funded podium presentations. Twenty-four (63%) have resident research requirements beyond the Accreditation Council for Graduate Medical Education (ACGME) mandate of preparing a "manuscript suitable for publication" prior to graduation. Twenty-five (67%) programs have residents with 2 to 3 active research projects at any given time. None of the investigated resources were significantly associated with increased scholarly output. There was no uniformity to research curricula. Conclusions Otolaryngology residency programs value research, evidenced by financial support provided and requirements beyond the ACGME minimum. Additional resources were not statistically related to an increase in resident research productivity, although they may contribute positively to the overall research experience during training. Potential future areas to examine include research curricula best practices, how to develop meaningful mentorship and resource allocation that inspires continued research interest, and intellectual stimulation.

  2. [Research progress of genetic engineering on medicinal plants].

    Science.gov (United States)

    Teng, Zhong-qiu; Shen, Ye

    2015-02-01

    The application of genetic engineering technology in modern agriculture shows its outstanding role in dealing with food shortage. Traditional medicinal plant cultivation and collection have also faced with challenges, such as lack of resources, deterioration of environment, germplasm of recession and a series of problems. Genetic engineering can be used to improve the disease resistance, insect resistance, herbicides resistant ability of medicinal plant, also can improve the medicinal plant yield and increase the content of active substances in medicinal plants. Thus, the potent biotechnology can play an important role in protection and large area planting of medicinal plants. In the development of medicinal plant genetic engineering, the safety of transgenic medicinal plants should also be paid attention to. A set of scientific safety evaluation and judgment standard which is suitable for transgenic medicinal plants should be established based on the recognition of the particularity of medicinal plants.

  3. Do gender and personality traits (BFI-10) influence attitude towards genetic research?

    DEFF Research Database (Denmark)

    Sudzina, Frantisek

    2016-01-01

    There is a continuing trend of making genetic research commercially available. It is not only 23andme that offers various types of genetic tests anymore. People do not need to rely on doctor's opinion, they can purchase genetic testing kits and test themselves. Unfortunately, not all available te...... tests are reliable; as the case of Theranos showed recently. The paper aims to investigate if there is any impact of gender and of personality traits on attitude towards genetic research. Big Five Inventory is used to measure personality traits....

  4. Beliefs and attitudes towards participating in genetic research – a population based cross-sectional study

    Directory of Open Access Journals (Sweden)

    Kerath Samantha M

    2013-02-01

    Full Text Available Abstract Background Biobanks have the potential to offer a venue for chronic disease biomarker discovery, which would allow for disease early detection and for identification of carriers of a certain predictor biomarker. To assess the general attitudes towards genetic research and participation in biobanks in the Long Island/Queens area of New York, and what factors would predict a positive view of such research, participants from the NSLIJ hospital system were surveyed. Methods Participants were recruited at six hospital centers in the NSLIJ system during the summers of 2009 and again in 2011 (n = 1,041. Those who opted to participate were given a questionnaire containing 22 questions assessing demographics, lifestyle and attitudes towards genetic research. These questions addressed individual participant’s beliefs about the importance of genetic research, willingness to participate in genetic research themselves, and their views on informed consent issues. Results Respondents took a generally positive view of genetic research in general, as well as their own participation in such research. Those with reservations were most likely to cite concerns over the privacy of their medical and genetic information. Those who were married tended to view genetic research as important, while those in the younger age group viewed it as less important. Prior blood donation of respondents was found to be a predictor of their approval for genetic research. Demographic factors were not found to be predictive of personal willingness to participate in genetic research, or of approval for the opt-out approach to consent. Conclusions While respondents were generally inclined to approve of genetic research, and those who disapproved did not do so based on an underlying moral objection to such research, there is a disconnect between the belief in the importance of genetic research and the willingness of individuals to participate themselves. This indicates a

  5. Evolving rule-based systems in two medical domains using genetic programming.

    Science.gov (United States)

    Tsakonas, Athanasios; Dounias, Georgios; Jantzen, Jan; Axer, Hubertus; Bjerregaard, Beth; von Keyserlingk, Diedrich Graf

    2004-11-01

    To demonstrate and compare the application of different genetic programming (GP) based intelligent methodologies for the construction of rule-based systems in two medical domains: the diagnosis of aphasia's subtypes and the classification of pap-smear examinations. Past data representing (a) successful diagnosis of aphasia's subtypes from collaborating medical experts through a free interview per patient, and (b) correctly classified smears (images of cells) by cyto-technologists, previously stained using the Papanicolaou method. Initially a hybrid approach is proposed, which combines standard genetic programming and heuristic hierarchical crisp rule-base construction. Then, genetic programming for the production of crisp rule based systems is attempted. Finally, another hybrid intelligent model is composed by a grammar driven genetic programming system for the generation of fuzzy rule-based systems. Results denote the effectiveness of the proposed systems, while they are also compared for their efficiency, accuracy and comprehensibility, to those of an inductive machine learning approach as well as to those of a standard genetic programming symbolic expression approach. The proposed GP-based intelligent methodologies are able to produce accurate and comprehensible results for medical experts performing competitive to other intelligent approaches. The aim of the authors was the production of accurate but also sensible decision rules that could potentially help medical doctors to extract conclusions, even at the expense of a higher classification score achievement.

  6. 76 FR 314 - Sorghum Promotion, Research, and Information Program: Referendum

    Science.gov (United States)

    2011-01-04

    ... DEPARTMENT OF AGRICULTURE Agricultural Marketing Service [Doc. No. AMS-LS-10-0103] Sorghum Promotion, Research, and Information Program: Referendum AGENCY: Agricultural Marketing Service, USDA. ACTION: Notice of Opportunity to Participate in the Sorghum Promotion, Research, and Information...

  7. U.S. Global Change Research Program Budget Crosscut

    Data.gov (United States)

    Office of Science and Technology Policy, Executive Office of the President — U.S. Global Change Research Program budget authority for Agency activities in which the primary focus is on:Observations, research, and analysis of climate change...

  8. Synchrotron radiation use in some researchs in program in Brazil

    International Nuclear Information System (INIS)

    Caticha-Ellis, S.

    1983-01-01

    Physical and biological applications of the synchrotron radiation in some pure and applied research programs in progress in Brazil are presented, in special those related with crystallografic research. (L.C.) [pt

  9. NRC/AMRMC Resident Research Associateship Program

    Science.gov (United States)

    2016-04-01

    8. Curcumin : A Prototype Anti-inflammatory Therapeutic for Burn Pain and Wound Healing. Burn and Trauma Research Workgroup. BAMMC Burn Center 2014 9...from Burkholderia infection in mice. 9) PUBLICATIONS AND PAPERS RESULTING FROM NRC ASSOCIATESHIP RESEARCH Provide complete citations: author(s), title...PUBLICATIONS AND PAPERS RESULTING FROM NRC ASSOCIATESHIP RESEARCH Provide complete citations: author(s), title, full name of journal, volume number, page

  10. Infectious Disease Clinical Research Program (IDCRP)

    Data.gov (United States)

    Federal Laboratory Consortium — Our mission is to conduct infectious disease clinical research of importance to the military through a unique, adaptive, and collaborative network, to inform health...

  11. The national standards program for research reactors

    International Nuclear Information System (INIS)

    Whittemore, W.L.

    1977-01-01

    In 1970 a standards committee called ANS-15 was established by the American Nuclear Society (ANS) to prepare appropriate standards for research reactors. In addition, ANS acts as Secretariat for a national standards committee N17 which is responsible to the American National Standards Institute (ANSI) for the national consensus efforts for standards related to research reactors. To date ANS-15 has completed or is working on 14 standards covering all aspects of the operation of research reactors. Of the 11 research reactor standards submitted to the ANSI N17 Committee since its inception, six have been issued as National standards, and the remaining are still in the process of review. (author)

  12. Karlsruhe Nuclear Research Center. Research and development program 1992

    International Nuclear Information System (INIS)

    1991-01-01

    The KfK R and D activities are classified by ten point-of-main-effort projects: 1) low-pollution/low-waste methods, 2) environmental energy and mass transfers, 3) nuclear fusion, 4) nuclear saftey research, 5) radioactive waste management, 6) superconduction, 7) microtechnics, 8) materials handling, 9) materials and interfaces, 10) basic physical research. (orig.) [de

  13. Aetiology of Depression: Insights from epidemiological and genetic research

    NARCIS (Netherlands)

    O. Story-Jovanova (Olivera)

    2018-01-01

    markdownabstractThis thesis includes several population-based studies that explore the aetiology of depression, with a specific interest on biological factors, genetics and epigenetics, and physical health factors for depression. Unravelling the aetiology of depression could potentially answer some

  14. Molecular markers for genetic diversity and phylogeny research of ...

    African Journals Online (AJOL)

    Brazilian sheep descended from several breeds brought to the New World by Portuguese and Spanish colonists, and they have evolved and adapted to local climatic variations and acquired tolerance or resistance to many diseases. Molecular markers are widely used in analyzing genetic variability, and markers such as ...

  15. FASEB Summer Research Conference. Genetic Recombination and Chromosome Rearrangements

    Energy Technology Data Exchange (ETDEWEB)

    Jinks-Robertson, Sue

    2002-02-01

    The 2001 meeting entitled ''Genetic Recombination and Genome Rearrangements'' was held July 21-26 in Snowmass, Colorado. The goal of the meeting was to bring together scientists using diverse approaches to study all aspects of genetic recombination. This goal was achieved by integrating talks covering the genetics, biochemistry and structural biology of homologous recombination, site-specific recombination, and nonhomologous recombination. The format of the meeting consisted of a keynote address on the opening evening, two formal plenary sessions on each of the four full meeting days, a single afternoon workshop consisting of short talks chosen from among submitted abstracts, and afternoon poster sessions on each of the four full meeting days. The eight plenary session were entitled: (1) Recombination Mechanisms, (2) Prokaryotic Recombination, (3) Repair and Recombination, (4) Site-specific Recombination and Transposition, (5) Eukaryotic Recombination I, (6) Genome Rearrangements, (7) Meiosis, and (8) Eukaryotic Recombination II. Each session included a mix of genetic, biochemical and structural talks; talks were limited to 20 minutes, followed by 10 minutes of very lively, general discussion. Much of the data presented in the plenary sessions was unpublished, thus providing attendees with the most up-to-date knowledge of this rapidly-moving field.

  16. RESEARCH NOTE Genetic Analyses for Deciphering the Status and ...

    Indian Academy of Sciences (India)

    Precision breeding for developing varieties for a specific area would involve ... Presently India is the fifth largest soybean producing country after US, Brazil, ... Genetic analysis at E3 and E4 loci and assessment of effect of photoperiodic ... outsourced (Scigenom, Banglore) for Sanger sequencing of coding region of E1.

  17. The NASA computer science research program plan

    Science.gov (United States)

    1983-01-01

    A taxonomy of computer science is included, one state of the art of each of the major computer science categories is summarized. A functional breakdown of NASA programs under Aeronautics R and D, space R and T, and institutional support is also included. These areas were assessed against the computer science categories. Concurrent processing, highly reliable computing, and information management are identified.

  18. SHARP {Summer High School Apprenticeship Research Program}

    Science.gov (United States)

    Glasco, Deborah (Technical Monitor)

    2002-01-01

    The Year 2002 was another successful year for SHARP. Even after 22 years of SHARP, the Program continues to grow. There were 12 NASA Field Installations with a total of 210 apprentices who participated in the summer 2002 Program supported by 215 mentors in the fields of science and engineering. The apprentices were chosen from a pool of 1,379 applicants. This was a record year for applications exceeding the previous year by over 60%. For the second consecutive year, the number of female participants exceeded the number of males with 53% female and 47% male participants in the program. The main thrust of our recruiting efforts is still focused on underrepresented populations; especially African American, Hispanic, and Native American. At the conclusion of the summer program, most SHARP Apprentices indicated on the EDCATS that they would be interested in pursuing careers in Aerospace (56.2%) while the second largest career choice was a job at NASA (45.7%). The smallest number (11.9%) were interested in careers in the government. The table of responses is listed in the Appendix. Once again this year we were fortunate in that the SHARP COTR, Ms. Deborah Glasco, gained the support of MURED funding sources at NASA to fully fund additional apprentices and boost the number of apprentices to 210.

  19. NASA's aviation safety - meteorology research programs

    Science.gov (United States)

    Winblade, R. L.

    1983-01-01

    The areas covering the meteorological hazards program are: severe storms and the hazards to flight generated by severe storms; clear air turbulence; icing; warm fog dissipation; and landing systems. Remote sensing of ozone by satellites, and the use of satellites as data relays is also discussed.

  20. Underlying chemistry research for the nuclear fuel waste management program

    International Nuclear Information System (INIS)

    Torgerson, D.F.; Sagert, N.H.; Shoesmith, D.W.; Taylor, P.

    1984-04-01

    This document reviews the underlying chemistry research part of the Canadian Nuclear Fuel Waste Management Program, carried out in the Research Chemistry Branch. This research is concerned with developing the basic chemical knowledge and under-standing required in other parts of the Program. There are four areas of underlying research: Waste Form Chemistry, Solute and Solution Chemistry, Rock-Water-Waste Interactions, and Abatement and Monitoring of Gas-Phase Radionuclides

  1. Towards programming languages for genetic engineering of living cells.

    Science.gov (United States)

    Pedersen, Michael; Phillips, Andrew

    2009-08-06

    Synthetic biology aims at producing novel biological systems to carry out some desired and well-defined functions. An ultimate dream is to design these systems at a high level of abstraction using engineering-based tools and programming languages, press a button, and have the design translated to DNA sequences that can be synthesized and put to work in living cells. We introduce such a programming language, which allows logical interactions between potentially undetermined proteins and genes to be expressed in a modular manner. Programs can be translated by a compiler into sequences of standard biological parts, a process that relies on logic programming and prototype databases that contain known biological parts and protein interactions. Programs can also be translated to reactions, allowing simulations to be carried out. While current limitations on available data prevent full use of the language in practical applications, the language can be used to develop formal models of synthetic systems, which are otherwise often presented by informal notations. The language can also serve as a concrete proposal on which future language designs can be discussed, and can help to guide the emerging standard of biological parts which so far has focused on biological, rather than logical, properties of parts.

  2. Enterprising or altruistic selves? Making up research subjects in genetics research.

    Science.gov (United States)

    Tutton, Richard; Prainsack, Barbara

    2011-11-01

    The emergence of direct-to-consumer (DTC) personal genomics companies in 2007 was accompanied by considerable media attention and criticism from clinical geneticists and other health professionals, regulators, policy advisors, and ethicists. As well as offering genetic testing services, some firms are also engaged in building their own databases and conducting research with the data obtained from their customers. In this paper, we examine how one of these companies, 23andMe, is creating a certain kind of 'research subject' in opposition to that constituted in conventional forms of disease research. Drawing on debates about neoliberalism, contemporary health discourses and subjectivity, we consider two kinds of subjectivities produced through the discursive and material practices of 23andMe and UK Biobank, namely, 'enterprising' and 'altruistic' selves. We argue that the 23andMe model promotes the idea that curiosity about one's genome on the one hand, and participation in research on the other, are not only compatible but complementary aspects of being an entrepreneurial subject of contemporary health and medicine framed by the technologies of web 2.0. © 2011 The Authors. Sociology of Health & Illness © 2011 Foundation for the Sociology of Health & Illness/Blackwell Publishing Ltd.

  3. Recent developments in genetics and medically assisted reproduction: from research to clinical applications.

    Science.gov (United States)

    Harper, J C; Aittomäki, K; Borry, P; Cornel, M C; de Wert, G; Dondorp, W; Geraedts, J; Gianaroli, L; Ketterson, K; Liebaers, I; Lundin, K; Mertes, H; Morris, M; Pennings, G; Sermon, K; Spits, C; Soini, S; van Montfoort, A P A; Veiga, A; Vermeesch, J R; Viville, S; Macek, M

    2018-01-01

    Two leading European professional societies, the European Society of Human Genetics and the European Society for Human Reproduction and Embryology, have worked together since 2004 to evaluate the impact of fast research advances at the interface of assisted reproduction and genetics, including their application into clinical practice. In September 2016, the expert panel met for the third time. The topics discussed highlighted important issues covering the impacts of expanded carrier screening, direct-to-consumer genetic testing, voiding of the presumed anonymity of gamete donors by advanced genetic testing, advances in the research of genetic causes underlying male and female infertility, utilisation of massively parallel sequencing in preimplantation genetic testing and non-invasive prenatal screening, mitochondrial replacement in human oocytes, and additionally, issues related to cross-generational epigenetic inheritance following IVF and germline genome editing. The resulting paper represents a consensus of both professional societies involved.

  4. Advances in genetics and immunology: the importance of basic research to prevention of occupational diseases

    International Nuclear Information System (INIS)

    Omenn, G.S.

    1984-01-01

    Differences among workers in susceptibility to workplace exposures to environmental agents such as metals, ultraviolet radiation, and x-radiation are discussed. The distinction is made between the need for (1) monitoring for effects on the genetic material (genetic toxicology) and (2) screening for predisposing inherited traits (eco-genetics). Genetically-determined differences in susceptibility are discussed in relation to mechanisms of metabolism and of target sites. While there is not enough evidence to support routine genetic screening at this time there is common agreement that several promising areas for research on potential genetic predispositions warrant careful study. There is also reassuring evidence that productive relationships for research can be established among unions, management, and universities. 56 references, 3 figures, 7 tables

  5. NRC/AMRMC Resident Research Associateship Program

    Science.gov (United States)

    2018-05-01

    data sources, gathering and maintaining the data needed, and completing and reviewing this collection of information. Send comments regarding this...with another U.S. government agency 0 Research/administrative position with foreign government agency 0 Research/teaching at US college/university 1

  6. ANSTO - Program of Research 1994-1995

    International Nuclear Information System (INIS)

    1994-01-01

    The report outlines the planned research and development activities for 1994-1995 in five major research units: Advanced Materials, Applications of Nuclear Physics, Biomedicine and Health, Environmental Sciences and the Safety and Reliability Centre. A list of recent publication originated from ANSTO's scientific and engineering activities is also included. ills

  7. ANSTO - Program of Research 1994-1995

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1994-12-31

    The report outlines the planned research and development activities for 1994-1995 in five major research units: Advanced Materials, Applications of Nuclear Physics, Biomedicine and Health, Environmental Sciences and the Safety and Reliability Centre. A list of recent publication originated from ANSTO`s scientific and engineering activities is also included. ills.

  8. NASA Ames Summer High School Apprenticeship Research Program

    Science.gov (United States)

    Powell, P.

    1985-01-01

    The Summer High School Apprenticeship Research Program (SHARP) is described. This program is designed to provide engineering experience for gifted female and minority high school students. The students from this work study program which features trips, lectures, written reports, and job experience describe their individual work with their mentors.

  9. Action Research: Effective Marketing Strategies for a Blended University Program

    Science.gov (United States)

    Cook, Ruth Gannon; Ley, Kathryn

    2008-01-01

    This action research study investigated a marketing plan based on collaboration among a program faculty team and other organizational units for a graduate professional program. From its inception through the second year of operation, program enrollment increased due to the marketing plan based on an effective approach grounded in simple marketing…

  10. Programs of the Office of Energy Research

    International Nuclear Information System (INIS)

    1990-01-01

    The Office of Energy Research sponsors long-term research in certain fundamental areas and in technical areas associated with energy resources, production, use, and resulting health and environmental effects. This document describes these activities, including recent accomplishments, types of facilities, and gives some impacts on energy, science, and scientific manpower development. The document is intended to respond to the many requests from diverse communities --- such as government, education, and public and private research --- for a summary of the types of research sponsored by the Department of Energy's Office of Energy Research. This is important since the Office relies to a considerable extent on unsolicited proposals from capable university and industrial groups, self-motivated interested individuals, and organizations that may wish to use the Department's extensive facilities and resources. By describing our activities and facilities, we hope not only to inform, but to also encourage interest and participation

  11. Human Research Program Science Management: Overview of Research and Development Activities

    Science.gov (United States)

    Charles, John B.

    2007-01-01

    An overview of research and development activities of NASA's Human Research Science Management Program is presented. The topics include: 1) Human Research Program Goals; 2) Elements and Projects within HRP; 3) Development and Maintenance of Priorities; 4) Acquisition and Evaluation of Research and Technology Proposals; and 5) Annual Reviews

  12. Overview of the Defense Programs Research and Technology Development Program for fiscal year 1993. Appendix II research laboratories and facilities

    Energy Technology Data Exchange (ETDEWEB)

    1993-09-30

    This document contains summaries of the research facilities that support the Defense Programs Research and Technology Development Program for FY 1993. The nine program elements are aggregated into three program clusters as follows: (1) Advanced materials sciences and technologies; chemistry and materials, explosives, special nuclear materials (SNM), and tritium. (2) Design sciences and advanced computation; physics, conceptual design and assessment, and computation and modeling. (3) Advanced manufacturing technologies and capabilities; system engineering science and technology, and electronics, photonics, sensors, and mechanical components. Section I gives a brief summary of 23 major defense program (DP) research and technology facilities and shows how these major facilities are organized by program elements. Section II gives a more detailed breakdown of the over 200 research and technology facilities being used at the Laboratories to support the Defense Programs mission.

  13. Institute of Genetics. Progress report on research and development activities in 1994

    International Nuclear Information System (INIS)

    1995-01-01

    The Institute of Genetics performed R and D work on the following subjects: Effects induced by radiation, oxygen radicals, and chemical mutagens; Regulation of genetic activity; Mechanisms of tumor spreading; Genetic models of mice for simulation of defects in man; p53 and the 'dioxin' receptor as targets of toxic agents. The research results achieved in the reporting period are reviewed and explained. (orig./MG) [de

  14. IAEA Co-ordinated Research Program (CRP)

    International Nuclear Information System (INIS)

    Schrenk, M.

    2010-01-01

    The Coordinated Research Project is a topical collection of research agreements and contracts. The research contracts are awarded with financial support of about 10-20% of the total contract cost. Among the activities of the project is the organization of consultant group meetings and workshops involving several international experts and representatives of users and developers of border radiation monitoring equipment. The project also supports in coordinating the development of equipment and techniques for up-to-date border monitoring and in establishing of a process for providing nuclear forensics support to member states

  15. Management program on radioactive wastes in research

    International Nuclear Information System (INIS)

    Xavier, Ana Maria; Wieland, Patricia; Heilbron Filho, Paulo Fernando L.; Ferreira, Rubemar de Souza

    1998-01-01

    This document has the objective to orient and advise the researchers to practice a safety management of radioactive wastes in each research laboratory, based upon the technical norms of the Brazilian Nuclear Energy Commission and the recommendations of the International Atomic Energy Agency. Additionally, basic information on the main radioisotopes used in research are presented, including the processes used for production of radioisotopes, methods for radiation detection, range of alpha and beta particles, background radiation, as well as principles on radioprotection and biological effects of radiation

  16. Western hardwoods : value-added research and demonstration program

    Science.gov (United States)

    D. W. Green; W. W. Von Segen; S. A. Willits

    1995-01-01

    Research results from the value-added research and demonstration program for western hardwoods are summarized in this report. The intent of the program was to enhance the economy of the Pacific Northwest by helping local communities and forest industries produce wood products more efficiently. Emphasis was given to value-added products and barriers to increased...

  17. North American long-term soil productivity research program

    Science.gov (United States)

    Allan E. Tiarks; Robert F. Powers; Jerry F. Ragus; Deborah S. Page-Dumroese; Felix Ponder; Douglas M. Stone

    1997-01-01

    The National Long-term Soil Productivity research program was chartered to address National Forest Management Act concerns over possible losses n soil productivity on national forest lands. The program supports validation of soil quality monitoring standards and process-level productivity research. Summarized results are supplied to forests as collected. National...

  18. National Institute on Disability and Rehabilitation Research Program Directory, 1999.

    Science.gov (United States)

    National Inst. on Disability and Rehabilitation Research (ED/OSERS), Washington, DC.

    This directory lists all projects funded by the National Institute of Disability and Rehabilitation Research (NIDRR) during the 1999 fiscal year. It includes summaries, funding data, and contact information for a broad range of programs. Programs are grouped into the following research priorities: (1) employment outcomes; (2) health and function;…

  19. The WIPP research and development test program

    International Nuclear Information System (INIS)

    Tyler, L.D.

    1985-01-01

    The WIPP (Waste Isolation Pilot Plant) is a DOE RandD Facility for the purpose of developing the technology needed for the safe disposal of the United States defense-related radioactive waste. The in-situ test program is defined for the thermal-structural interactions, plugging and sealing, and waste package interactions in a salt environment. An integrated series of large-scale underground tests address the issues of both systems and long-term isolation performance of a repository

  20. Summer Prostate Cancer Research Training Program

    Science.gov (United States)

    2017-09-01

    pathways underlying pathological cell proliferation in the setting of cancer. Current efforts are focused on selecting RNA aptamers to receptors...museums (art, natural history, and sports). In addition, there are a large number of restaurants ranging from fast food to fine dining. Application...there are a large number of restaurants ranging from fast food to fine dining. Application to the Program - Application forms, distributed with

  1. CEC radiation protection research and training program

    International Nuclear Information System (INIS)

    Gerber, G.B.

    1991-01-01

    The Radiation Protection Program (RPP), initiated as a consequence of the Euratom Treaty aims to promote: scientific knowledge to evaluate possible risks from low doses of natural, medical and man-made radiation; development of methods to assess radiological risks; incentive and support for cooperation between scientists of Member States; expertise in radiation protection by training scientists and the scientific basis for continual updating of the 'Basic Safety Standards', and the evolution of radiation protection concepts and practices. 3 refs

  2. Structural Metadata Research in the Ears Program

    Science.gov (United States)

    2005-01-01

    detecting structural information in the word stream (the so-called “structural MDE” portion of the EARS program); other MDE efforts on speaker ... diarization are overviewed in [13]. The rest of this paper is organized as follows. We describe the structural MDE tasks, performance measurement, and corpora...tems have only recently been introduced, with NIST reporting re- sults with the Wilcoxon signed rank test for speaker -level average score differences

  3. Advanced Pediatric Brain Imaging Research Program

    Science.gov (United States)

    2016-10-01

    pediatric magnetic resonance imaging ( MRI ) techniques are revolutionizing our understanding of brain injury, its potential for recovery, and...training program, advanced MRI , brain injury. 16. SECURITY CLASSIFICATION OF: 17. LIMITATION OF ABSTRACT 18. NUMBER OF PAGES 19a. NAME OF RESPONSIBLE...is located at www.MilitaryMedED.com. The site can be accessed from any device web browser (personal computer, tablet or phone) and operating system

  4. Research program plan: reactor vessels. Volume 1

    International Nuclear Information System (INIS)

    Vagins, M.; Taboada, A.

    1985-07-01

    The ability of the licensing staff of the NRC to make decisions concerning the present and continuing safety of nuclear reactor pressure vessels under both normal and abnormal operating conditions is dependent upon the existence of verified analysis methods and a solid background of applicable experimental data. It is the role of this program to provide both the analytical methods and the experimental data needed. Specifically, this program develops fracture mechanics analysis methods and design criteria for predicting the stress levels and flaw sizes required for crack initiation, propagation, and arrest in LWR pressure vessels under all known and postulated operations conditions. To do this, not only must the methods be developed but they must be experimentally validated. Further, the materials data necessary for input to these analytical methods must be developed. Thus, in addition to methods development and large scale experimental verification this program also develops data to show that slow-load fracture toughness, rapid-load fracture toughness, and crack arrest toughness obtained from small laboratory specimens are truly representative of the toughness characteristics of the material behavior in pressure vessels in both the unirradiated and the irradiated conditions

  5. Selecting the Best Forecasting-Implied Volatility Model Using Genetic Programming

    Directory of Open Access Journals (Sweden)

    Wafa Abdelmalek

    2009-01-01

    Full Text Available The volatility is a crucial variable in option pricing and hedging strategies. The aim of this paper is to provide some initial evidence of the empirical relevance of genetic programming to volatility's forecasting. By using real data from S&P500 index options, the genetic programming's ability to forecast Black and Scholes-implied volatility is compared between time series samples and moneyness-time to maturity classes. Total and out-of-sample mean squared errors are used as forecasting's performance measures. Comparisons reveal that the time series model seems to be more accurate in forecasting-implied volatility than moneyness time to maturity models. Overall, results are strongly encouraging and suggest that the genetic programming approach works well in solving financial problems.

  6. Academic training: From Evolution Theory to Parallel and Distributed Genetic Programming

    CERN Multimedia

    2007-01-01

    2006-2007 ACADEMIC TRAINING PROGRAMME LECTURE SERIES 15, 16 March From 11:00 to 12:00 - Main Auditorium, bldg. 500 From Evolution Theory to Parallel and Distributed Genetic Programming F. FERNANDEZ DE VEGA / Univ. of Extremadura, SP Lecture No. 1: From Evolution Theory to Evolutionary Computation Evolutionary computation is a subfield of artificial intelligence (more particularly computational intelligence) involving combinatorial optimization problems, which are based to some degree on the evolution of biological life in the natural world. In this tutorial we will review the source of inspiration for this metaheuristic and its capability for solving problems. We will show the main flavours within the field, and different problems that have been successfully solved employing this kind of techniques. Lecture No. 2: Parallel and Distributed Genetic Programming The successful application of Genetic Programming (GP, one of the available Evolutionary Algorithms) to optimization problems has encouraged an ...

  7. A Summary of the Naval Postgraduate School Research Program, 1982

    OpenAIRE

    Faculty of the Naval Postgraduate School

    1982-01-01

    Approved For Public Release; Distribution Unlimited This report contains 224 summaries on research projects which were carried out under funding to the Naval Postgraduate School Research Program. This research was carried out in the areas of Computer Science, Mathematics, Administrative Sciences, Operations Research, National Security Affairs, Physics and Chemistry, Electrical Engineering, Meterology, Aeronautics, Oceanography and Mechanical Engineering. The Table of Content...

  8. A Summary of the Naval Postgraduate School Research Program, 1983

    OpenAIRE

    Faculty of the Naval Postgraduate School

    1983-01-01

    Approved For Public Release; Distribution Unlimited This report contains 249 summaries on research projects which were carried out under funding to the Naval Postgraduate School Research Program. This research was carried out in the areas of Computer Science, Mathematics, Administrative Sciences, Operations Research, National Security Affairs, Physics, Electrical Engineering, Meterology, Aeronautics, Oceanography and Mechanical Engineering. The Table of Contents identifies t...

  9. A Summary of the Naval Postgraduate School Research Program, 1984

    OpenAIRE

    Faculty of the Naval Postgraduate School

    1984-01-01

    Approved for public release; distribution unlimited. This report contains 221 summaries on research projects which were carried out under funding to the Naval Postgraduate School Research Program. This research was carried out in the areas of Computer Science, Mathematics, Administrative Sciences, Operations Research, National Security Affairs, Physics, Electrical Engineering, Meterology, Aeronautics, Oceanography and Mechanical Engineering. The Table of Contents identifies ...

  10. Summary reports of activities under visiting research program (1993)

    International Nuclear Information System (INIS)

    1993-10-01

    The summary reports of activities under visiting research program in the Research Reactor Institute, Kyoto University, in fiscal year 1992 are included. In this report, 104 summaries of researches using the Kyoto University Reactor (KUR) and 9 summaries of the researches using the Kyoto University Critical Assembly (KUCA) are collected. (J.P.N.)

  11. Research Award: Supporting Inclusive Growth program Deadline ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Jean-Claude Dumais

    2012-09-12

    Sep 12, 2012 ... results, participating in project development, monitoring, communication and learning activities, and preparing internal and external reports. Candidates should have the following qualifications: • Strong research, analysis, and writing skills for different audiences (academic, policy, general public);.

  12. Research Award: Agriculture and Food Security Program

    International Development Research Centre (IDRC) Digital Library (Canada)

    IDRC CRDI

    social) without adverse consequences to societies and the environment. ... research will place particular attention on the interactions of public sector ... Applicants should clearly outline their qualifications for this position, and explain how this ...

  13. MoDOT pavement preservation research program.

    Science.gov (United States)

    2014-08-01

    The following report documents a research project on pavement preservation performed by the Missouri University of Science and : Technology (Missouri S&T) and the University of Missouri-Columbia (UMC) on behalf of the Missouri Department of Transport...

  14. A research Program in Elementary Particle Physics

    Energy Technology Data Exchange (ETDEWEB)

    Sobel, Henry; Molzon, William; Lankford, Andrew; Taffard, Anyes; Whiteson, Daniel; Kirkby, David

    2013-07-25

    Work is reported in: Neutrino Physics, Cosmic Rays and Elementary Particles; Particle Physics and Charged Lepton Flavor Violation; Research in Collider Physics; Dark Energy Studies with BOSS and LSST.

  15. Early 20th-century research at the interfaces of genetics, development, and evolution: reflections on progress and dead ends.

    Science.gov (United States)

    Deichmann, Ute

    2011-09-01

    Three early 20th-century attempts at unifying separate areas of biology, in particular development, genetics, physiology, and evolution, are compared in regard to their success and fruitfulness for further research: Jacques Loeb's reductionist project of unifying approaches by physico-chemical explanations; Richard Goldschmidt's anti-reductionist attempts to unify by integration; and Sewall Wright's combination of reductionist research and vision of hierarchical genetic systems. Loeb's program, demanding that all aspects of biology, including evolution, be studied by the methods of the experimental sciences, proved highly successful and indispensible for higher level investigations, even though evolutionary change and properties of biological systems up to now cannot be fully explained on the molecular level alone. Goldschmidt has been appraised as pioneer of physiological and developmental genetics and of a new evolutionary synthesis which transcended neo-Darwinism. However, this study concludes that his anti-reductionist attempts to integrate genetics, development and evolution have to be regarded as failures or dead ends. His grand speculations were based on the one hand on concepts and experimental systems that were too vague in order to stimulate further research, and on the other on experiments which in their core parts turned out not to be reproducible. In contrast, Sewall Wright, apart from being one of the architects of the neo-Darwinian synthesis of the 1930s, opened up new paths of testable quantitative developmental genetic investigations. He placed his research within a framework of logical reasoning, which resulted in the farsighted speculation that examinations of biological systems should be related to the regulation of hierarchical genetic subsystems, possibly providing a mechanism for development and evolution. I argue that his suggestion of basing the study of systems on clearly defined properties of the components has proved superior to

  16. Research and development program in reactor safety for NUCLEBRAS

    International Nuclear Information System (INIS)

    Pinheiro, R.B.; Resende Lobo, A.A. de; Horta, J.A.L.; Avelar Esteves, F. de; Lepecki, W.P.S.; Mohr, K.; Selvatici, E.

    1984-01-01

    With technical assistance from the IAEA, it was established recently an analytical and experimental Research and Development Program for NUCLEBRAS in the area of reactor safety. The main objectives of this program is to make possible, with low investments, the active participation of NUCLEBRAS in international PWR safety research. The analytical and experimental activities of the program are described with some detail, and the main results achieved up to now are presented. (Author) [pt

  17. NRC/AMRMC Resident Research Associateship Program

    Science.gov (United States)

    2016-04-27

    stem-cell released molecule as a therapy in blast-injured retina Miller, Christine 2/4/2013-2/3/2016 1 Optimized protocol to isolate, identify, and...derived self-formed optic cups in laser-injured retina 7) SUMMARY OF RESEARCH DURING TENURE Itemize significant findings in concise form, utilizing key...during retinogenesis 5) Formulate a research plan on using stem-cell released molecule as a therapy in blast-injured retina (USMA Davies Fellow: please

  18. SKB's program for societal research 2004-2011. An evaluation

    International Nuclear Information System (INIS)

    Soederberg, Olof

    2012-04-01

    This evaluation of the program of societal research that SKB conducted the years 2004-2011 has been performed on behalf of Swedish Nuclear Fuel and Waste Management Company (SKB). The review has focused on answers to a series of questions as follows: General questions - Why was a program started? - What was SKB's purpose with the program? - Does the result mean that the objective has been achieved? - Has the program had effects (positive or negative) that were not anticipated when the purpose was formulated? - Strengths and weaknesses of the program? Questions about the implementation - How did announcement and selection procedures work? - Which forms were used for reporting results from the research projects? Questions about the continued investment in societal research - Are there such needs? - In that case, is it in SKB's interest to contribute financially to such research? - What forms might be appropriate if SKB sees interest to contribute financially to such research?

  19. Optimization Research of Generation Investment Based on Linear Programming Model

    Science.gov (United States)

    Wu, Juan; Ge, Xueqian

    Linear programming is an important branch of operational research and it is a mathematical method to assist the people to carry out scientific management. GAMS is an advanced simulation and optimization modeling language and it will combine a large number of complex mathematical programming, such as linear programming LP, nonlinear programming NLP, MIP and other mixed-integer programming with the system simulation. In this paper, based on the linear programming model, the optimized investment decision-making of generation is simulated and analyzed. At last, the optimal installed capacity of power plants and the final total cost are got, which provides the rational decision-making basis for optimized investments.

  20. Acceptable respiratory protection program and LASL respirator research

    International Nuclear Information System (INIS)

    Skaggs, B.J.

    1979-01-01

    A short history is presented on the LASL Respiratory Protection Training Programs. Then a discussion is given on the major points of an acceptable respiratory protection program utilizing the points required by the Occupational, Safety, and Health Administration (OSHA) Regulation 29 CFR 1910.134. Contributions to respirator research are reviewed. Discussion is presented under the following section headings: program administration; respirator selection; respirator use; fitting and training; respirator maintenance; medical clearance and surveillance; special problems; program evaluation; and documentation

  1. Energy Consumption Forecasting Using Semantic-Based Genetic Programming with Local Search Optimizer

    Directory of Open Access Journals (Sweden)

    Mauro Castelli

    2015-01-01

    Full Text Available Energy consumption forecasting (ECF is an important policy issue in today’s economies. An accurate ECF has great benefits for electric utilities and both negative and positive errors lead to increased operating costs. The paper proposes a semantic based genetic programming framework to address the ECF problem. In particular, we propose a system that finds (quasi-perfect solutions with high probability and that generates models able to produce near optimal predictions also on unseen data. The framework blends a recently developed version of genetic programming that integrates semantic genetic operators with a local search method. The main idea in combining semantic genetic programming and a local searcher is to couple the exploration ability of the former with the exploitation ability of the latter. Experimental results confirm the suitability of the proposed method in predicting the energy consumption. In particular, the system produces a lower error with respect to the existing state-of-the art techniques used on the same dataset. More importantly, this case study has shown that including a local searcher in the geometric semantic genetic programming system can speed up the search process and can result in fitter models that are able to produce an accurate forecasting also on unseen data.

  2. Genetically determined patozoospermia. Literature review and research results

    Directory of Open Access Journals (Sweden)

    E. E. Bragina

    2015-01-01

    Full Text Available Genetic factors (chromosomal aberrations and point mutations are the cause of infertility in 10–15 % of men with impaired fertility. Homogeneous structural and functional defects in the sperm or the total terato-, asthenozoospermia – rare cases of genetically determined male infertility, are autosomal recessive diseases. Currently, described 4 types of «syndromic» spermopatology. 1. Primary ciliary dyskinesia (PCD in men with total asthenozoospermia. Affects axoneme structures (microtubules, dynein arms, radial spokes. It identified more than 20 chromosomal loci responsible for the development of the PCD. 2. Dysplasia of the fibrous sheath of sperm tail in men with asthenozoospermia. The shortened and thickened sperm tail observed with disorganization of vertical columns and cross ribs of the fibrous sheath. Candidate genes – genes family ACAP. 3. Globozoospermia in men with teratozoospermia characterized by the presence of sperm with round heads, primary lack of acrosome and disorganization middle part of the flagellum. Found mutations or deletions of genes SPATA16, PICK1 and DPY19L2. 4. Syndrome decapitated spermatozoa in men with teratozoospermia (microcephaly. Abnormalities in the spermiogenesis development of connecting part jf the tail and proximal (morphologically normal centrioles.In 2012–2014 years we have studied the ultrastructure of 2267 semen samples of men with impaired fertility. Globozoospermia revealed in 7 patients, dysplasia of the fibrous sheath – 13, decapitated sperm – in one. PCD was revealed in 4 patients (lack of axoneme dynein arms was found in 1 patient, absence of axoneme radial spokes – in 3 patients.The problem of genetically determined patozoospermya must be taken into account when the assisted reproductive technologies practises. There are few cases of successful assisted reproductive technologies with sperm of these patients. We don»t know the etiological factors of syndromic spermopatologe, so

  3. A Program of Research and Education in Astronautics at the NASA Langley Research Center

    Science.gov (United States)

    Tolson, Robert H.

    2000-01-01

    The objectives of the Program were to conduct research at the NASA Langley Research Center in the area of astronautics and to provide a comprehensive education program at the Center leading to advanced degrees in Astronautics. We believe that the program has successfully met the objectives and has been of significant benefit to NASA LaRC, the GWU and the nation.

  4. Laboratory Directed Research and Development Program: FY 2015 Annual Report

    Energy Technology Data Exchange (ETDEWEB)

    SLAC,

    2016-04-04

    The Department of Energy (DOE) and the SLAC National Accelerator Laboratory (SLAC) encourage innovation, creativity, originality and quality to maintain the Laboratory’s research activities and staff at the forefront of science and technology. To further advance its scientific research capabilities, the Laboratory allocates a portion of its funds for the Laboratory Directed Research and Development (LDRD) program. With DOE guidance, the LDRD program enables SLAC scientists to make rapid and significant contributions that seed new strategies for solving important national science and technology problems. The LDRD program is conducted using existing research facilities.

  5. Comments on the NRC Safety Research Program budget

    International Nuclear Information System (INIS)

    1979-07-01

    This report includes comments on the budget levels and program plans for the supplemental request for FY 1980 to support research related to the accident at Three Mile Island, Unit 2 (TMI) as well as for the FY 1981 Budget. For both budgets, the funding levels considered by the ACRS are the original requests by RES and the Budget Review Group (BRG) markup as of July 10, 1979. In its current review of the NRC research program, the ACRS has given special attention to both the short- and long-term implications of the TMI accident and their significance to research for both the short- and long-term research programs

  6. Program nuclear safety research: report 2000

    International Nuclear Information System (INIS)

    Muehl, B.

    2001-09-01

    The reactor safety R and D work of forschungszentrum karlsruhe (FZK) had been part of the nuclear safety research project (PSF) since 1990. In 2000, a new organisational structure was introduced and the Nuclear Safety Research Project was transferred into the nuclear safety research programme (NUKLEAR). In addition to the three traditional main topics - Light Water Reactor safety, Innovative systems, Studies related to the transmutation of actinides -, the new Programme NUKLEAR also covers Safety research related to final waste storage and Immobilisation of HAW. These new topics, however, will only be dealt with in the next annual report. Some tasks related to the traditional topics have been concluded and do no longer appear in the annual report; other tasks are new and are described for the first time. Numerous institutes of the research centre contribute to the work programme, as well as several external partners. The tasks are coordinated in agreement with internal and external working groups. The contributions to this report, which are either written in German or in English, correspond to the status of early/mid 2001. (orig.)

  7. Regulating human genetic research in Latin America: a race to the top or a race together?

    Directory of Open Access Journals (Sweden)

    Rosario Isasi

    2016-05-01

    Full Text Available Balancing the therapeutic potential of genetic science with the adoption of policies that reflect social values has proven to be a formidable task for Latin American countries. This essay presents some reflections on human genetics research policy in Latin America and explores a path forward for policy development.

  8. Disclosure of individual genetic data to research participants: the debate reconsidered

    NARCIS (Netherlands)

    Bredenoord, A.L.; Kroes, H.Y.; Cuppen, E.; Parker, M.; van Delden, J.J.M.

    2010-01-01

    Despite extensive debate, there is no consensus on whether individual genetic data should be disclosed to research participants. The emergence of whole-genome sequencing methods is increasingly generating unequalled amounts of genetic data, making the need for a clear feedback policy even more

  9. Materials and corrosion programs sponsored by the Gas Research Institute

    International Nuclear Information System (INIS)

    Flowers, A.

    1980-01-01

    The paper deals briefly with the Gas Research Institute and its research in materials and corrosion. As a not-for-profit organization, the Gas Research Institute plans, finances, and manages applied and basic research and technological development programs associated with gaseous fuels. These programs are in the general areas of production, transportation, storage, utilization and conservation of natural and manufactured gases and related products. Research results, whether experimental or analytical, are evaluated and publicly disseminated. Materials and corrosion research is concentrated in the SNG from Coal and Non-fossil Hydrogen subprograms

  10. Exploratory Technology Research Program for electrochemical energy storage

    Science.gov (United States)

    Kinoshita, Kim

    1994-09-01

    The U.S. Department of Energy's Office of Propulsion Systems provides support for an Electrochemical Energy Storage Program, that includes research and development (R&D) on advanced rechargeable batteries and fuel cells. A major goal of this program is to develop electrochemical power sources suitable for application in electric vehicles (EV's). The program centers on advanced systems that offer the potential for high performance and low life-cycle costs, both of which are necessary to permit significant penetration into commercial markets. The DOE Electrochemical Energy Storage Program is divided into two projects: the Electric Vehicle Advanced Battery Systems (EVABS) Development Program and the Exploratory Technology Research (ETR) Program. The EVABS Program management responsibility has been assigned to Sandia National Laboratories (SNL); Lawrence Berkeley Laboratory (LBL) is responsible for management of the ETR Program. The EVABS and ETR Programs include an integrated matrix of R&D efforts designed to advance progress on selected candidate electrochemical systems. The United States Advanced Battery Consortium (USABC), a tripartite undertaking between DOE, the U.S. automobile manufacturers and the Electric Power Research Institute (EPRI), was formed in 1991 to accelerate the development of advanced batteries for consumer EV's. The role of the FIR Program is to perform supporting research on the advanced battery systems under development by the USABC and EVABS Program, and to evaluate new systems with potentially superior performance, durability and/or cost characteristics. The specific goal of the ETR Program is to identify the most promising electrochemical technologies and transfer them to the USABC, the battery industry and/or the EVABS Program for further development and scale-up. This report summarizes the research, financial and management activities relevant to the ETR Program in CY 1993.

  11. Multidisciplinary research program directed toward utilization of solar energy through bioconversion of renewable resources

    Energy Technology Data Exchange (ETDEWEB)

    1980-07-01

    Progress is reported in this multidisciplinary research program. Genetic selection of superior trees, physiological basis of vigor, tissue culture systems leading to cloning of diploid and haploid cell lines are discussed in the Program A report. The physiological basis of enhanced oleoresin formation in southern pines when treated with sublethal concentrations of the herbicide paraquat was investigated in Program B. In Program C, metabolic changes in the stems of slash pine, in vivo, after application with paraquat were determined. The use of phdoem and xylem tissue slices as a laboratory model for studying paraquat associated- and normal-terpene synthesis in pines is discussed. The biochemistry and physiology of methane formation from cellulose during anaerobic fermentation are discussed in the Program D report. (DMC)

  12. Building Innovation and Sustainability in Programs of Research.

    Science.gov (United States)

    Villarruel, Antonia M

    2018-01-01

    Innovation and sustainability are two important concepts of impactful programs of research. While at first glance these concepts and approaches may seem at odds, they are synergistic. We examine the social, political, and policy context as it relates to innovation and sustainability. We present an exemplar of a program of research and discuss factors to consider in developing innovative and sustainable programs of research. Innovation is an important component of sustainable programs of research. Understanding the social and political context and addressing relevant policy issues are factors to be considered in both innovation and sustainability. Innovation and sustainability, important components of research, are also central to clinical practice. Open communication between researchers and clinicians can support the acceleration of innovations and the integration of evidence-based findings in practice. © 2017 Sigma Theta Tau International.

  13. Building a Bridge Between Genetics and Outcomes Research: Application in Autism (The AutGO Study).

    Science.gov (United States)

    Talebizadeh, Zohreh; Shah, Ayten

    2018-03-05

    Concerns over the need to improve translational aspects of genetics research studies and engaging community members in the research process have been noted in the literature and raised by patient advocates. In addition to the work done by patient advocacy groups, organizations such as the Patient-Centered Outcomes Research Institute advocate for a change in the culture of research from being researcher-driven to becoming more patient-driven. Our project, Autism Genetics and Outcomes (AutGO), consists of two phases. The goal for phase I was to initiate a general discussion around the main topic (i.e., linking genetics and outcomes research). We used the Patient-Centered Outcomes Research Institute engagement approach to: (aim 1) develop a partnership with a wide range of stakeholders to assess their perspective on developing projects that use both genetics and outcomes research data/principles; (aim 2) identify barriers, facilitators, and needs to promote engagement in patient-centered genetics research; and (aim 3) distill and describe actions that may facilitate utilization of patient/parent perspectives in designing genetics research studies. In phase I, we formed a community advisory board composed of 33 participants, including outcomes and genetics researchers, clinicians, healthcare providers, patients/family members, and community/industry representatives, and convened six sessions over the 12-month period. We structured the sessions as a combination of online PowerPoint presentations, surveys, and in-person group discussions. During the sessions, we discussed topics pertaining to linking genetics and outcomes research and reviewed relevant materials, including patient stories, research projects, and existing resources. Two sets of surveys, project evaluations (k = 2) and session evaluations (k = 6), were distributed among participants. Feedback was analyzed using content analysis strategies to identify the themes and subthemes. Herein, we describe: the

  14. NRC/AMRMC Resident Research Associateship Program

    Science.gov (United States)

    2015-05-01

    aspirate characterization for the support of large animal studies. Research in Veterinary Science; In preparation, expected submission February 2015...Activity of Norspermidine Against Clinical Orthopaedic Isolates. (Manuscript Submitted to BMC Microbiology ) Albach AM, Hardy SK, Chang DC, Garcia RG...American Society for Microbiology (ASM) General Meeting. San Francisco, CA. June 15-19,2012. Carlos J. Sanchez Jr. Biofilm-Derived Factors Reduce

  15. U.S. Global Change Research Program

    Science.gov (United States)

    ... Announcing... Read more The Deepening Story of How Climate Change Threatens Human Health Read more Celebrating the 25th Anniversary of the U.S. Global Change Research... Read more Nomination Period Open for the Sustained National ... more Connecting America’s Communities with Actionable Climate ...

  16. NRC/AMRMC Resident Research Associateship Program

    Science.gov (United States)

    2015-05-01

    maintaining a presence on social media sites such as Facebook . The NRC attended a number of minority focused events in which we maintained exhibit booths...PROPOSAL The Use of Glial Inhibitors to Increase the Efficacy of Opioid Analgesics while Eliminating the Propensity for Addiction 7) SUMMARY OF RESEARCH

  17. The southern plains LTAR watershed research program

    Science.gov (United States)

    Patrick Starks; Jean L. Steiner

    2016-01-01

    Water connects physical, biological, chemical, ecological, and economic forces across the landscape. While hydrologic processes and scientific investigations related to sustainable agricultural systems are based on universal principles, research to understand processes and evaluate management practices is often site-specific in order to achieve a critical mass of...

  18. The AFT Educational Research and Dissemination Program

    Science.gov (United States)

    American Federation of Teachers, 2007

    2007-01-01

    This brochure is developed to provide information for local unions within the American Federation of Teachers (AFT) who may be interested in becoming Education Research and Dissemination (ER&D) sites. The following questions are addressed: (1) What Is ER&D? (2) What Can ER&D Accomplish? (3) What Makes ER&D Different? (4) What Do ER&D Participants…

  19. Overview of the Nuclear Regulatory Commission's safety research program

    International Nuclear Information System (INIS)

    Beckjord, E.S.

    1989-01-01

    Accomplishments during 1988 of the Office of Nuclear Regulatory Research and the program of safety research are highlighted, and plans, expections, and needs of the next year and beyond are discussed. Topics discussed include: ECCS Appendix K Revision; pressurized thermal shock; NUREG-1150, or the PRA method performance document; resolution of station blackout; severe accident integration plan; nuclear safety research review committee; and program management

  20. Laboratory Directed Research and Development Program FY 2006 Annual Report

    Energy Technology Data Exchange (ETDEWEB)

    Sjoreen, Terrence P [ORNL

    2007-04-01

    The Oak Ridge National Laboratory (ORNL) Laboratory Directed Research and Development (LDRD) Program reports its status to the US Departmental of Energy (DOE) in March of each year. The program operates under the authority of DOE Order 413.2B, 'Laboratory Directed Research and Development' (April 19, 2006), which establishes DOE's requirements for the program while providing the Laboratory Director broad flexibility for program implementation. LDRD funds are obtained through a charge to all Laboratory programs. This report includes summaries all ORNL LDRD research activities supported during FY 2006. The associated FY 2006 ORNL LDRD Self-Assessment (ORNL/PPA-2007/2) provides financial data about the FY 2006 projects and an internal evaluation of the program's management process.

  1. Primary prevention research: a preliminary review of program outcome studies.

    Science.gov (United States)

    Schaps, E; Churgin, S; Palley, C S; Takata, B; Cohen, A Y

    1980-07-01

    This article reviews 35 drug abuse prevention program evaluations employing drug-specific outcome measures. Many of these evaluations assessed the effects of "new generation" prevention strategies: affective, peer-oriented, and multidimensional approaches. Only 14 studies evaluated purely informational programs. Evaluations were analyzed to ascertain (1) characteristics of the programs under study, (2) characteristics of the research designs, and (3) patterns among findings. This review provides some evidence that the newer prevention strategies may produce more positive and fewer negative outcomes than did older drug information approaches. Over 70% of the programs using the newer strategies produced some positive effects; only 29% showed negative effects. In contrast, 46% of informational programs showed positive effects; 46% showed negative effects. These findings must be approached with great caution, since the research was frequently scientifically inadequate, and since rigor of research was negatively correlated with intensity and duration of program services.

  2. 1993 Annual report on scientific programs: A broad research program on the sciences of complexity

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1993-12-31

    This report provides a summary of many of the research projects completed by the Santa Fe Institute (SFI) during 1993. These research efforts continue to focus on two general areas: the study of, and search for, underlying scientific principles governing complex adaptive systems, and the exploration of new theories of computation that incorporate natural mechanisms of adaptation (mutation, genetics, evolution).

  3. National Geospatial-Intelligence Agency Academic Research Program

    Science.gov (United States)

    Loomer, S. A.

    2004-12-01

    "Know the Earth.Show the Way." In fulfillment of its vision, the National Geospatial-Intelligence Agency (NGA) provides geospatial intelligence in all its forms and from whatever source-imagery, imagery intelligence, and geospatial data and information-to ensure the knowledge foundation for planning, decision, and action. To achieve this, NGA conducts a multi-disciplinary program of basic research in geospatial intelligence topics through grants and fellowships to the leading investigators, research universities, and colleges of the nation. This research provides the fundamental science support to NGA's applied and advanced research programs. The major components of the NGA Academic Research Program (NARP) are: - NGA University Research Initiatives (NURI): Three-year basic research grants awarded competitively to the best investigators across the US academic community. Topics are selected to provide the scientific basis for advanced and applied research in NGA core disciplines. - Historically Black College and University - Minority Institution Research Initiatives (HBCU-MI): Two-year basic research grants awarded competitively to the best investigators at Historically Black Colleges and Universities, and Minority Institutions across the US academic community. - Director of Central Intelligence Post-Doctoral Research Fellowships: Fellowships providing access to advanced research in science and technology applicable to the intelligence community's mission. The program provides a pool of researchers to support future intelligence community needs and develops long-term relationships with researchers as they move into career positions. This paper provides information about the NGA Academic Research Program, the projects it supports and how other researchers and institutions can apply for grants under the program.

  4. Possible research program on a large scale nuclear pressure vessel

    International Nuclear Information System (INIS)

    1983-01-01

    The nuclear pressure vessel structural integrity is actually one of the main items in the nuclear plants safety field. An international study group aimed at investigating the feasibility of a ''possible research program'' on a scale 1:1 LWR pressure vessel. This report presents the study group's work. The different research programs carried out or being carried out in various countries of the European Community are presented (phase I of the study). The main characteristics of the vessel considered for the program and an evaluation of activities required for making them available are listed. Research topic priorities from the different interested countries are summarized in tables (phase 2); a critical review by the study group of the topic is presented. Then, proposals for possible experimental programs and combination of these programs are presented, only as examples of possible useful research activities. The documents pertaining to the results of phase I inquiry performed by the study group are reported in the appendix

  5. Computer Presentation Programs and Teaching Research Methodologies

    Directory of Open Access Journals (Sweden)

    Vahid Motamedi

    2015-05-01

    Full Text Available Supplementing traditional chalk and board instruction with computer delivery has been viewed positively by students who have reported increased understanding and more interaction with the instructor when computer presentations are used in the classroom. Some problems contributing to student errors while taking class notes might be transcription of numbers to the board, and handwriting of the instructor can be resolved in careful construction of computer presentations. The use of computer presentation programs promises to increase the effectiveness of learning by making content more readily available, by reducing the cost and effort of producing quality content, and by allowing content to be more easily shared. This paper describes how problems can be overcome by using presentation packages for instruction.

  6. Researcher responsibilities and genetic counseling for pure-bred dog populations.

    Science.gov (United States)

    Bell, Jerold S

    2011-08-01

    Breeders of dogs have ethical responsibilities regarding the testing and management of genetic disease. Molecular genetics researchers have their own responsibilities, highlighted in this article. Laboratories offering commercial genetic testing should have proper sample identification and quality control, official test result certificates, clear explanations of test results and reasonably priced testing fees. Providing test results to a publicly-accessible genetic health registry allows breeders and the public to search for health-tested parents to reduce the risk of producing or purchasing affected offspring. Counseling on the testing and elimination of defective genes must consider the effects of genetic selection on the population. Recommendations to breed quality carriers to normal-testing dogs and replacing them with quality normal-testing offspring will help to preserve breeding lines and breed genetic diversity. Copyright © 2011 Elsevier Ltd. All rights reserved.

  7. Genetic algorithms and genetic programming for multiscale modeling: Applications in materials science and chemistry and advances in scalability

    Science.gov (United States)

    Sastry, Kumara Narasimha

    2007-03-01

    Effective and efficient rnultiscale modeling is essential to advance both the science and synthesis in a, wide array of fields such as physics, chemistry, materials science; biology, biotechnology and pharmacology. This study investigates the efficacy and potential of rising genetic algorithms for rnultiscale materials modeling and addresses some of the challenges involved in designing competent algorithms that solve hard problems quickly, reliably and accurately. In particular, this thesis demonstrates the use of genetic algorithms (GAs) and genetic programming (GP) in multiscale modeling with the help of two non-trivial case studies in materials science and chemistry. The first case study explores the utility of genetic programming (GP) in multi-timescaling alloy kinetics simulations. In essence, GP is used to bridge molecular dynamics and kinetic Monte Carlo methods to span orders-of-magnitude in simulation time. Specifically, GP is used to regress symbolically an inline barrier function from a limited set of molecular dynamics simulations to enable kinetic Monte Carlo that simulate seconds of real time. Results on a non-trivial example of vacancy-assisted migration on a surface of a face-centered cubic (fcc) Copper-Cobalt (CuxCo 1-x) alloy show that GP predicts all barriers with 0.1% error from calculations for less than 3% of active configurations, independent of type of potentials used to obtain the learning set of barriers via molecular dynamics. The resulting method enables 2--9 orders-of-magnitude increase in real-time dynamics simulations taking 4--7 orders-of-magnitude less CPU time. The second case study presents the application of multiobjective genetic algorithms (MOGAs) in multiscaling quantum chemistry simulations. Specifically, MOGAs are used to bridge high-level quantum chemistry and semiempirical methods to provide accurate representation of complex molecular excited-state and ground-state behavior. Results on ethylene and benzene---two common

  8. NRC/AMRMC Resident Research Associateship Program

    Science.gov (United States)

    2017-04-01

    workshops and advertised in meeting literature, newsletters and websites or submitted materials for distribution. In addition, ads were placed in a...item follows: 9.8 Short-term value (lab)-Development of knowledge, skills, and research productivity at lab 9.7 Long-term value (career)-How your...REPORT 1) Associate Last or Family Name Cohen First Name Courtney M.I. A 2) FORWARDING Address (to which your tax statement will be mailed) Residence

  9. Summer Student Breast Cancer Research Training Program

    Science.gov (United States)

    2006-05-01

    kinase inhibition on ERK activity in breast cancer cells, the role of the calpain proteolytic pathway in breast cancer-induced cachexia , and the...research training; breast cancer; fatty acids and prevention; nutrition and prevention; alternative prevention 16. SECURITY CLASSIFICATION OF...growth. In in vivo experiments, mice were fed diets that were rich in either omega-3 (fish oil) or omega-6 (corn oil) fatty acids. Three weeks after

  10. NRC/AMRMC Resident Research Associateship Program

    Science.gov (United States)

    2015-03-01

    provided the administrative functions described in the contract Statement of Work. These functions included stipend payments, management of a major...Pain Management Clinic, focus on translational work from bench to bedside, clinical research involving opioid use and long term outcomes 2 Developed...They invited me to share American Holidays with them, like Thanksgiving, so that I had the possibility to experience traditions along with culinary

  11. Coconut Program Area Research Planning and Prioritization

    OpenAIRE

    Aragon, Corazon

    2000-01-01

    The coconut industry is one of the country's major pillars in employment generation and foreign exchange earnings. However, local production problems, the expansion in coconut hectarage of neighboring countries, and recent developments in biotechnology research on other competing crops that have high lauric oil content might affect its long-term sustainability and viability. In a highly liberalized global trade environment, innovation and creativity in the country's coconut industry are neede...

  12. Teacher Research Experience Programs = Increase in Student Achievement

    Science.gov (United States)

    Dubner, J.

    2010-12-01

    Columbia University's Summer Research Program for Science Teachers (SRP), founded in 1990, is one of the largest, best known university-based professional development programs for science teachers in the U.S. The program’s basic premise is simple: teachers cannot effectively teach science if they have not experienced it firsthand. For eight weeks in each of two consecutive summers, teachers participate as a member of a research team, led by a member of Columbia University’s research faculty. In addition to the laboratory experience, all teachers meet as a group one day each week during the summer for a series of pedagogical activities. A unique quality of the Summer Research Program is its focus on objective assessment of its impact on attitudes and instructional practices of participating teachers, on the performance of these teachers in their mentors’ laboratories, and most importantly, on the impact of their participation in the program on student interest and performance in science. SRP uses pass rate on the New York State Regents standardized science examinations as an objective measure of student achievement. SRP's data is the first scientific evidence of a connection between a research experience for teachers program and gains in student achievement. As a result of the research, findings were published in Science Magazine. The author will present an overview of Columbia's teacher research program and the results of the published program evaluation.

  13. Lewis' Educational and Research Collaborative Intership Program Grant Closeout Report

    Science.gov (United States)

    2003-01-01

    The Lewis' Educational and Research Collaborative Internship Program (LERCIP) is a collaborative undertaking by the Office of Educational Programs at NASA Glenn Research Center at Lewis Field (formerly NASA Lewis Research Center) and the Ohio Aerospace Institute. This program provides 10-week internships and 10 or 12-week fellowships for undergraduate/graduate students and secondary school teachers. Approximately 130 interns are selected to participate in this program each year and begin arriving the second week in May. The internships provide students with introductory professional experiences to complement their academic programs. The interns are given assignments on research and development projects under the personal guidance of NASA professional staff members. Each intern is assigned a NASA mentor who facilitates a research assignment. In addition to the research assignment, the summer program includes a strong educational component that enhances the professional stature of the participants. The educational activities include a research symposium and a variety of workshops, lectures and short courses. An important aspect of the program is that it includes students with diverse social, cultural and economic backgrounds.

  14. Attitudes Toward Genetic Modification Research: An Analysis of the Views of the Sputnik Generation.

    Science.gov (United States)

    Miller, Jon D.

    1982-01-01

    Utilizing data from the 1977 National Assessment of Educational Progress (NAEP) survey of young adults, summarizes attitudes toward genetic modification research and the demographic, educational, and occupational correlates of these attitudes. (Author/SK)

  15. Program Analysis and Its Relevance for Educational Research

    Directory of Open Access Journals (Sweden)

    Bernd Käpplinger

    2008-01-01

    Full Text Available Program analyses are frequently used in research on continuing education. The use of such analyses will be described in this article. Existing data sources, research topics, qualitative, quantitative and mixed methods, will be discussed. Three types of program analysis will be developed. The article ends with a discussion of the advantages and disadvantages of program analysis in contrast to questionnaires. Future developments and challenges will be sketched in the conclusion. Recommendations for the future development of program analysis will be given. URN: urn:nbn:de:0114-fqs0801379

  16. The historical role of species from the Solanaceae plant family in genetic research.

    Science.gov (United States)

    Gebhardt, Christiane

    2016-12-01

    This article evaluates the main contributions of tomato, tobacco, petunia, potato, pepper and eggplant to classical and molecular plant genetics and genomics since the beginning of the twentieth century. Species from the Solanaceae family form integral parts of human civilizations as food sources and drugs since thousands of years, and, more recently, as ornamentals. Some Solanaceous species were subjects of classical and molecular genetic research over the last 100 years. The tomato was one of the principal models in twentieth century classical genetics and a pacemaker of genome analysis in plants including molecular linkage maps, positional cloning of disease resistance genes and quantitative trait loci (QTL). Besides that, tomato is the model for the genetics of fruit development and composition. Tobacco was the major model used to establish the principals and methods of plant somatic cell genetics including in vitro propagation of cells and tissues, totipotency of somatic cells, doubled haploid production and genetic transformation. Petunia was a model for elucidating the biochemical and genetic basis of flower color and development. The cultivated potato is the economically most important Solanaceous plant and ranks third after wheat and rice as one of the world's great food crops. Potato is the model for studying the genetic basis of tuber development. Molecular genetics and genomics of potato, in particular association genetics, made valuable contributions to the genetic dissection of complex agronomic traits and the development of diagnostic markers for breeding applications. Pepper and eggplant are horticultural crops of worldwide relevance. Genetic and genomic research in pepper and eggplant mostly followed the tomato model. Comparative genome analysis of tomato, potato, pepper and eggplant contributed to the understanding of plant genome evolution.

  17. The second workshop of neutron science research program

    Energy Technology Data Exchange (ETDEWEB)

    Yasuda, Hideshi [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment; Tone, Tatsuzo [eds.

    1997-11-01

    The Japan Atomic Energy Research Institute(JAERI) has been proposing the Neutron Science Research Program to explore a broad range of basic research and the nuclear technology including actinide transmutation with use of powerful spallation neutron sources. For this purpose, the JAERI is conducting the research and development of an intense proton linac, the development of targets, as well as the conceptual design study of experimental facilities required for applications of spallation neutrons and secondary particle beams. The Special Task Force for Neutron Science Initiative was established in May 1996 to promote aggressively and systematically the Neutron Science Research Program. The second workshop on neutron science research program was held at the JAERI Tokai Research Establishment on 13 and 14 March 1997 for the purpose of discussing the results obtained since the first workshop in March 1996. The 27 of the presented papers are indexed individually. (J.P.N.)

  18. Hybrid single node genetic programming for symbolic regression

    NARCIS (Netherlands)

    Kubalìk, Jiřì; Alibekov, Eduard; Žegklitz, Jan; Babuska, R.; Nguyen, NT; Kowalczyk, R; Filipe, J

    2016-01-01

    This paper presents a first step of our research on designing an effective and efficient GP-based method for symbolic regression. First, we propose three extensions of the standard Single Node GP, namely (1) a selection strategy for choosing nodes to be mutated based on depth and performance of

  19. Genetic research at a fivefold children's burial from medieval Berlin.

    Science.gov (United States)

    Rothe, Jessica; Melisch, Claudia; Powers, Natasha; Geppert, Maria; Zander, Judith; Purps, Josephine; Spors, Birgit; Nagy, Marion

    2015-03-01

    Berlin originated from the two twin cities Berlin and Cölln, which both were founded at the beginning of the 13th century. However the real date of their foundation as well as the origin of the first settlers is still unknown. On the Berlin site the historic city center is still visible in the Nikolaiviertel, but the medieval origin of Cölln disappeared almost completely. In 2007 a large scale excavation, which comprised an area of about 1700m(2) of the historical center of the St. Peters church, recovers the remains of Cölln's first citizens and span a period of 500 years of medieval population. Here we present the first genetic analysis of a fivefold children's burial from excavations in Berlin. The genetic data unveiled next to ancestry and eye color data also the kinship and the gender of the five individuals. Together with the archeological context the new gained information help to shed more light on the possible reasons for this burial. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

  20. [The importance of genealogy applied to genetic research in Costa Rica].

    Science.gov (United States)

    Meléndez Obando, Mauricio O

    2004-09-01

    The extensive development of genealogical studies based on archival documents has provided powerful support for genetic research in Costa Rica over the past quarter century. As a result, several questions of population history have been answered, such as those involving hereditary illnesses, suggesting additional avenues and questions as well. Similarly, the preservation of massive amounts of historical documentation highlights the major advantages that the Costa Rican population offers to genetic research.