Epigenetics Europe conference. Munich, Germany, 8-9 September 2011.

Science.gov (United States)

Jeltsch, Albert

2011-12-01

At the Epigenetics Europe conference in Munich, Germany, held on 8-9 September 2011, 19 speakers from different European countries were presenting novel data and concepts on molecular epigenetics. The talks were mainly focused on questions of the generation, maintenance, flexibility and erasure of DNA methylation patterns in context of other epigenetic signals like histone tail modifications and ncRNAs.

A universal model of giftedness - adaptation of the Munich Model

NARCIS (Netherlands)

Jessurun, J.H.; Shearer, C.B.; Weggeman, M.C.D.P.

2016-01-01

The Munich Model of Giftedness (MMG) by Heller and his colleagues, developed for the identification of gifted children, is adapted and expanded, with the aim of making it more universally usable as a model for the pathway from talents to performance. On the side of the talent-factors, the concept of

“Inspired by real events”—Media (and Memory in Steven Spielberg’s MUNICH (2005

Directory of Open Access Journals (Sweden)

Thomas Nachreiner

2016-02-01

Full Text Available Steven Spielberg’s 2005 film Munich tells the story of an Israeli counter-terrorist team in the aftermath of the hijacking and massacre at the Olympic Games in 1972. The film spawned broad discussion about its historical accuracy and its political standpoint. While criticism primarily focused on the historiographical representation of the actions depicted, this paper analyzes in two steps the genuinely filmic mode of historical representation ofMunich. First, the analysis discusses the interplay of two conflicting narrative strategies that negotiate the character development with the political struggle. And second, analysis focuses on the two formal devices at the core of the narrative conflict: The reflexive framing of television in the depiction of the Munich massacre as a traumatic media event and the excessive transformation of its memory in a series of flashbacks. Such elaboration of the narrative and formal strategies reveals the implicit historiographical structures of the film and suggests that the notion of ‘cultural trauma’ serves as the preferential—but problematic—template in telling the history of terrorism and violence.

The localization of marbles from busts of the Residence at Munich

International Nuclear Information System (INIS)

Riederer, J.; Hoefs, J.

1980-01-01

51 Greek, Roman and Renaissance marble busts from the Antiquarium of the Residence in Munich were studied for their C- and O-isotopic composition. Apart from some overlapping values, this technique permits - contrary to microscopic and chemical methods - localization of different Turkish, Greek and Italian marbel deposits. (orig.) [de

On the evaluation of the Munich-Frascati Werber-type experiment

International Nuclear Information System (INIS)

Kafka, Peter

1974-01-01

The theory of optimal evaluation is sketched and applied to the case of short pulses of gravitational radiation. The concepts of one-detector and multi-detector sensitivity are clarified. Comparison of the equivalent circuits of various detectors and tests with artificial pulses show that the pulses reported by Weber should be detectable in coincidence between Munich and Frascati. First negative results are presented

The REX-ISOLDE-project and the Munich Accelerator for Fission Fragments MAFF

CERN Document Server

Habs, D; Assmann, R W; Emhofer, S; Engels, O; Gross, M; Kester, O; Maier, H J; Reiter, P; Sieber, T; Thirolf, P G

2001-01-01

After a general discussion of ISOL-facilities in Europe we focus on the present status of the REX-ISOLDE facility at CERN and the Munich Accelerator for Fission Fragments MAFF. At REX-ISOLDE in 2001 radioactive beams of ISOLDE will be accelerated to (0.8-2.4) MeV/u. At the new Munich high-flux reactor FRM-II a production target of MAFF with 10$^{14}$ fissions/s is under design. Probably in 2003 intense low-energy beams ( approximately=10$^{11}$/s) of very neutron-rich fission fragments will be available. For MAFF a linac is being developed, which will accelerate the ions after charge breeding to energies between 3.7 and 5.9 MeV/u. In the long term a recycling ring with large momentum acceptance will further increase the radioactive beam intensities by a factor of 10$^{2}$-10$^{3}$ for specific experiments. (33 refs).

75 FR 21295 - Notice of Meeting: Secretary's Advisory Committee on Genetics, Health, and Society

Science.gov (United States)

2010-04-23

... Advisory Committee on Genetics, Health, and Society Pursuant to Public Law 92-463, notice is hereby given of the twenty-second meeting of the Secretary's Advisory Committee on Genetics, Health, and Society... Committee welcomes hearing from anyone wishing to provide public comment on any issue related to genetics...

75 FR 21002 - Notice of Meeting: Secretary's Advisory Committee on Genetics, Health, and Society

Science.gov (United States)

2010-04-22

...'s Advisory Committee on Genetics, Health, and Society Pursuant to Public Law 92-463, notice is hereby given of the twenty-second meeting of the Secretary's Advisory Committee on Genetics, Health, and... Committee welcomes hearing from anyone wishing to provide public comment on any issue related to genetics...

Meaningful, entertaining, popular and ‘Bavarian’: art into design in nineteenth century Munich

Directory of Open Access Journals (Sweden)

Stefan Muthesius

2014-12-01

Full Text Available Among European regional stereotypes few come across as strongly and consistently as ‘Bavaria’. Its strength is derived from the ways in which it appears to be firmly and comprehensively grounded in its land and its people. This article traces the way in which some of the stereotype’s associated forms and images, principally those related to the domestic environment, were first conceived during the nineteenth century. The principal claim is that it was the nineteenth century artists, architects and designers in the Kunststadt Munich, who, helped by the critics, arrived at very specific valorisations of their designs, which could then be applied in an essentialist way to all artefacts of the region, old or new. The article divides the Munich design activities into two phases. During the 1850s designers aimed for a poetic and ‘volkstümlich / popular’ kind of decoration of common objects, including scenes from Bavarian ‘folk’ poetry. In the second phase, during the 1870s and 1880s, interest turned more directly to the domestic environment of Alpine houses, valorising a plain wooden character. Clearly, an absolute belief in in a primeval and unchanging ‘Bavaria’ cannot be entertained any more. But neither should one classify it all as modern kitsch. The latter attitude must be the reason why the subject has hardly been touched on in the copious art histories of Munich so far.

A Universal Model of Giftedness--An Adaptation of the Munich Model

Science.gov (United States)

Jessurun, J. H.; Shearer, C. B.; Weggeman, M. C. D. P.

2016-01-01

The Munich Model of Giftedness (MMG) by Heller and his colleagues, developed for the identification of gifted children, is adapted and expanded, with the aim of making it more universally usable as a model for the pathway from talents to performance. On the side of the talent-factors, the concept of multiple intelligences is introduced, and the…

Major maintenance of the Munich MP-tandem

International Nuclear Information System (INIS)

Muenzer, H.; Carli, W.; Hartung, P.; Jakob, H.; Nocker, H.; Rohrer, L.; Schnitter, H.; Assmann, W.; Maier, H.J.; Machlitt, N.; Steffens, H.

1988-01-01

Several measures have been taken to restore the voltage performance of the Munich tandem. 1. All accelerator tubes were reconditioned by sandblasting, new electrodes and diaphragms were inserted and preassembled groups of tubes were baked in high vacuum. 2. All other vacuum components were cleaned, baked in high vacuum and partly pressure leak tested outside the tandem. 3. High voltage tests were performed with tubes. Without portico voltages up to 16 MV were obtained, with portico up to 17.5 MV. 4. Some modifications (e.g. infrared light links) were introduced. The shutdown lasted 6 months. In March 1987 beam operation was resumed at moderate terminal voltages, interrupted by intervals of soft conditioning. (orig.)

Motion and landscape : Otl Aicher, Günther Grzimek and the graphic and garden designs of the 1972 Munich Olympics.

OpenAIRE

Schiller, Kay; Young, Christopher

2010-01-01

This article focuses on Otl Aicher's design and Günther Grzimek's garden architecture for the 1972 Munich Olympics. We argue that the functionalist aesthetics of the Munich Olympic site should be interpreted as a translation into graphic and landscape design of 1960s progressivism in West German society and democracy. In the process Aicher and Grzimek somewhat paradoxically drew on the tradition of the Olympic Gesamtkunstwerk inaugurated in Berlin in 1936.

Radiographic Morphometry of the Lumbar Spine in Munich Miniature Pigs†

Science.gov (United States)

Engelke, Elisabeth C; Post, Christina; Pfarrer, Christiane D; Sager, Martin; Waibl, Helmut R

2016-01-01

The incidence of human spinal column disease remains high, and animal models still play important roles in prophylactic, diagnostic, and therapeutic research. Because of their similar size to humans, pigs remain an important spine model. For pigs to serve as a model for the human spine, basic similarities and differences must be understood. In this study, morphometric data of the lumbar spine of Munich miniature pigs (Troll) were recorded radiologically, evaluated, and compared with recorded human data. Whereas humans have a constant number of 5 lumbar vertebrae, Munich minipigs had 5 or 6 lumbar vertebrae. Compared with their human counterparts, the lumbar vertebral bodies of the minipigs were remarkably larger in the craniocaudal (superior–inferior) direction and considerably smaller in the dorsoventral and laterolateral directions. The porcine vertebral canal was smaller than the human vertebral canal. The spinal cord extended into the caudal part of the porcine lumbar vertebral canal and thus did not terminate as cranial, as seen in humans. The lumbar intervertebral spaces of the pig were narrower in craniocaudal direction than human intervertebral spaces. These differences need to be considered when planning surgical actions, not only to avoid pain and irreversible damage to the minipigs but also to achieve accurate scientific results. PMID:27177570

Psychiatric research and science policy in Germany: the history of the Deutsche Forschungsanstalt fur Psychiatrie (German Institute for Psychiatric Research) in Munich from 1917 to 1945).

Science.gov (United States)

Weber, M M

2000-09-01

The Deutsche Forschungsanstalt fur Psychiatrie (DFA) in Munich, one of the most important research institutes in the field of theoretical and clinical psychiatry, was founded in 1917 by Emil Kraepelin. Its financial existence between the world wars was assured by generous donations from the Jewish American scholar and philanthropist James Loeb. The scientific work done by Walther Spielmeyer (neuropathology), Felix Plaut (serology), Kurt Schneider (clinical psychiatry) and Ernst Rudin (psychiatric genetics) earned the DFA a reputation as an international center for psychiatry and neurology. During the 'Third Reich' Ernst Rudin cooperated with the National Socialist health system. His genetic concepts provided support for eugenic programmes such as forced sterilization of individuals with psychoses. These complex interactions underscore the importance of the DFA in understanding the recent history of medicine in Germany.

Medical genetic services in Latin America: report of a meeting of experts

Directory of Open Access Journals (Sweden)

Penchaszadeh Víctor B

1998-01-01

Full Text Available During the Ninth International Congress of Human Genetics which was held in Rio de Janeiro, Brazil, from 16 to 18 August 1996, a group of experts under the coordination of the authors discussed at length the state of medical genetics in Latin America. The facts and ideas presented at the meeting, which was sponsored by the Human Genetics Program of the World Health Organization (WHO and the Maternal and Child Health Program of the Pan American Health Organization, are examined in this document under three broad headings. The first verses on the history and current status of medical genetics in selected Latin American countries. This is followed by a discussion of the general features of medical genetics in the Region and by a final section of recommendations for promoting medical genetics in Latin America.

Neuropathological research at the "Deutsche Forschungsanstalt fuer Psychiatrie" (German Institute for Psychiatric Research) in Munich (Kaiser-Wilhelm-Institute). Scientific utilization of children's organs from the "Kinderfachabteilungen" (Children's Special Departments) at Bavarian State Hospitals.

Science.gov (United States)

Steger, Florian

2006-09-01

During National Socialism, the politically motivated interest in psychiatric genetic research lead to the founding of research departments specialized in pathological-anatomical brain research, the two Kaiser Wilhelm-Institutes (KWI) in Berlin and Munich. The latter was indirectly provided with brain material by Bavarian State Hospitals, to three of which "Kinderfachabteilungen" (Special Pediatric Units) were affiliated. As children became victims of the systematically conducted child "euthanasia" in these Special Pediatric Units, this paper will address the question whether and to which extent the organs from victims of child "euthanasia" were used for (neuro-) pathological research at the KWI in Munich. By means of case studies and medical histories (with focus on the situation in Kaufbeuren-Irsee), I will argue that pediatric departments on a regular base delivered slide preparations, that the child "euthanasia" conduced in these departments systematically contributed to neuropathological research and that slide preparations from victims of child "euthanasia" were used in scientific publications after 1945.

Nuclear energy and risk - experts meeting in November 1977 in Munich

Energy Technology Data Exchange (ETDEWEB)

Danzmann, H J

1978-02-01

As nuclear energy in public discussion is assessed not only by its benefit for the national economy, but above all by its risk, the interest in the subject was demonstrated by experts and public alike. The central point of the meeting was the German reactor safety study, apostrophized as 'Birkmussen Report', as in this report - under the leadership of A. Birkhofer - the applicability of the results of the American reactor safety study WASH-1400, the 'Rasmussen Report' (the final version of which appeared two years ago) on German conditions is investigated.

Status of the Munich compact core reactor project

International Nuclear Information System (INIS)

Boening, K.; Glaeser, W.; Meier, J.; Rau, G.; Roehrmoser, A.; Steichele, E.

1991-01-01

A new national, high performance research reactor is being planned in Munich which shall provide an unperturbed thermal neutron flux of about 8.10 14 cm -2 s -1 at only 20 MW power. This object can be achieved with the concept of a small, light water cooled 'compact core' situated in the center of a large heavy water moderator tank. In the first part of this paper an overview is given on the status of the necessary fuel enrichment is discussed. In becomes clear that the potential of the compact core concept can only be developed without compromises when using highly enriched uranium in combination with the new high density fuel. (orig.)

The Imaging and Cognition Genetics Conference 2011, ICG 2011: A meeting of minds

Directory of Open Access Journals (Sweden)

Stephanie eLe Hellard

2012-05-01

Full Text Available In June 2011, seventy researchers from the disciplines of cognitive science, genetics, psychology, psychiatry, neurobiology and computer science gathered in Os, Norway, for the first Imaging and Cognition Genetics meeting. The aim of the conference was to discuss progress, enhance collaboration and maximise resource sharing within this new field. Here we summarise some of the major themes that emerged from ICG 2011.

The Munich MIDY Pig Biobank – A unique resource for studying organ crosstalk in diabetes

Directory of Open Access Journals (Sweden)

Andreas Blutke

2017-08-01

Conclusions: The broad spectrum of well-defined biosamples in the Munich MIDY Pig Biobank that will be available to the scientific community provides a unique resource for systematic studies of organ crosstalk in diabetes in a multi-organ, multi-omics dimension.

The Third International Meeting on Genetic Disorders in the RAS/MAPK Pathway: Toward a Therapeutic Approach

OpenAIRE

Korf, Bruce; Ahmadian, Reza; Allanson, Judith; Aoki, Yoko; Bakker, Annette; Wright, Emma Burkitt; Denger, Brian; Elgersma, Ype; Gelb, Bruce D.; Gripp, Karen W.; Kerr, Bronwyn; Kontaridis, Maria; Lazaro, Conxi; Linardic, Corinne; Lozano, Reymundo

2015-01-01

"The Third International Meeting on Genetic Disorders in the RAS/MAPK Pathway: Towards a Therapeutic Approach" was held at the Renaissance Orlando at SeaWorld Hotel (August 2-4, 2013). Seventy-one physicians and scientists attended the meeting, and parallel meetings were held by patient advocacy groups (CFC International, Costello Syndrome Family Network, NF Network and Noonan Syndrome Foundation). Parent and patient advocates opened the meeting with a panel discussion to set the stage regard...

Comparison of the Munich Chronotype Questionnaire with the Horne-Östberg’s Morningness-Eveningness Score

NARCIS (Netherlands)

Zavada, Andrei; Gordijn, Marijke C.M.; Beersma, Domien G.M.; Daan, Serge; Roenneberg, Till

2005-01-01

We report on results from an Internet survey of sleeping habits in a Dutch population using the Munich Chronotype Questionnaire (MCTQ), supplemented with the Horne-Östberg Morningness-Eveningness Questionnaire (MEQ). The MCTQ was completed by 5,055 responders, of which 2,481 also completed the MEQ.

76 FR 6623 - Molecular and Clinical Genetics Panel of the Medical Devices Advisory Committee; Notice of Meeting

Science.gov (United States)

2011-02-07

... DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration [Docket No. FDA-2011-N-0066] Molecular and Clinical Genetics Panel of the Medical Devices Advisory Committee; Notice of Meeting AGENCY... public. Name of Committee: Molecular and Clinical Genetics Panel of the Medical Devices Advisory...

Regional Income and Employment Effects of the 1972 Munich Olympic Summer Games

OpenAIRE

Stephanie Jasmand; Wolfgang Maennig

2007-01-01

Abstract Olympic Games may have impacts on income and employment in the host city, but no ex post study has been carried out for European Olympic host cities to date. The present study closes this gap using the 1972 Munich Olympic Games. The data period examined in this study allows for analysis of long-term effects. In addition, the methodology avoids overestimating the significance of the effects. Finally, we report results for all possible combinations of pre- and post-Olympic p...

Ground depositions and air concentrations of Chernobyl fallout radionuclides at Munich-Neuherberg

Energy Technology Data Exchange (ETDEWEB)

Hoetzl, H.; Rosner, G.; Winkler, R.

1987-01-01

Southern Bavaria has received a comparatively high deposition of fallout radionuclides from the reactor accident at Chernobyl. As a result, in addition to the measurement of numerous gamma emitting nuclides and of strontium isotopes, the determination of several actinides, including isotopes of uranium, neptunium, plutonium and curium was possible. The observed radionuclide composition of the fallout and the time course of ground deposition and air concentration at the site of the Gesellschaft fuer Strahlen- und Umweltforschung (GSF) at Neuherberg, 10 km north of Munich, are reported and discussed.

Ground depositions and air concentrations of Chernobyl fallout radionuclides at Munich-Neuherberg

International Nuclear Information System (INIS)

Hoetzl, H.; Rosner, G.; Winkler, R.

1987-01-01

Southern Bavaria has received a comparatively high deposition of fallout radionuclides from the reactor accident at Chernobyl. As a result, in addition to the measurement of numerous gamma emitting nuclides and of strontium isotopes, the determination of several actinides, including isotopes of uranium, neptunium, plutonium and curium was possible. The observed radionuclide composition of the fallout and the time course of ground deposition and air concentration at the site of the Gesellschaft fuer Strahlen- und Umweltforschung (GSF) at Neuherberg, 10 km north of Munich, are reported and discussed. (orig.)

Cubierta para naves de grandes dimensiones en hormigón, Munich (Alemania Federal

Directory of Open Access Journals (Sweden)

Bomhard, H.

1972-05-01

Full Text Available This article describes the study, design and building of wide span concrete halls which, at present, are greatly influenced by the advances made in pre-stressed concrete, préfabrication and the development of modern building methods, as well as the new techniques in building with light concrete. The influence which gave origin to these halls is also described. Chosen as an example is the hall, with a span of 150 metres and a maximum hight of 27.30 metres, for the Munich goods station, showing the importance of this type of construction.El artículo describe el estudio, proyecto y construcción de naves de gran luz en hormigón que, en el momento actual, están decisivamente influenciadas por los adelantos en hormigón pretensado, en prefabricación y por el desarrollo de los modernos métodos de construcción, así como por las nuevas técnicas de la construcción en hormigones ligeros. Se detalla igualmente la influencia que originan estas naves de grandes dimensiones. Se toma como ejemplo la nave, de 150 m de luz y 27,30 m de altura máxima, para la estación de mercancías de Munich, haciendo patente su gran importancia en este tipo de construcciones.

Radiobiological experiments at the Munich ion microbeam SNAKE

Energy Technology Data Exchange (ETDEWEB)

Friedl, A.A.; Drexler, G.A.; Loewe, R. [Strahlenbiologisches Inst., Ludwig-Maximilians-Univ. Muenchen (Germany); Dollinger, G.; Hauptner, A.; Hable, V.; Greubel, C.; Kruecken, R. [Physik Dept. E12, Technische Univ. Muenchen, Garching (Germany); Cremer, T.; Dietzel, S. [Dept. Biologie II, Ludwig-Maximilians-Univ. Muenchen, Planegg-Martinsried (Germany)

2005-07-01

The ion microbeam SNAKE at the Munich 14 MV tandem accelerator was recently adapted for irradiation of cells and is now routinely used for radiobiological experiments. Several features, including ion-optical beam focussing to achieve a targeting accuracy of about 500 nm, fast movement of the beam by electrostatic deflection and single ion preparation make SNAKE an excellent tool for localized irradiation with a defined number of ions. The ion spectrum available ranges from 20 MeV protons to 200 MeV gold ions, thus allowing to vary the LET over four orders of magnitude and to conduct low and high LET irradiation in a single experimental set-up. This offers the possibility of a systematic analysis of the cellular response mechanisms in their dependence on dose and LET. Other current lines of research include analysis of the spatio-temporal dynamics of protein recruitment at damaged chromatin sites and determination of the mobility of damaged chromatin regions in the interphase nucleus. (orig.)

Multi-scale modeling of urban air pollution: development and application of a Street-in-Grid model (v1.0) by coupling MUNICH (v1.0) and Polair3D (v1.8.1)

Science.gov (United States)

Kim, Youngseob; Wu, You; Seigneur, Christian; Roustan, Yelva

2018-02-01

A new multi-scale model of urban air pollution is presented. This model combines a chemistry-transport model (CTM) that includes a comprehensive treatment of atmospheric chemistry and transport on spatial scales down to 1 km and a street-network model that describes the atmospheric concentrations of pollutants in an urban street network. The street-network model is the Model of Urban Network of Intersecting Canyons and Highways (MUNICH), which consists of two main components: a street-canyon component and a street-intersection component. MUNICH is coupled to the Polair3D CTM of the Polyphemus air quality modeling platform to constitute the Street-in-Grid (SinG) model. MUNICH is used to simulate the concentrations of the chemical species in the urban canopy, which is located in the lowest layer of Polair3D, and the simulation of pollutant concentrations above rooftops is performed with Polair3D. Interactions between MUNICH and Polair3D occur at roof level and depend on a vertical mass transfer coefficient that is a function of atmospheric turbulence. SinG is used to simulate the concentrations of nitrogen oxides (NOx) and ozone (O3) in a Paris suburb. Simulated concentrations are compared to NOx concentrations measured at two monitoring stations within a street canyon. SinG shows better performance than MUNICH for nitrogen dioxide (NO2) concentrations. However, both SinG and MUNICH underestimate NOx. For the case study considered, the model performance for NOx concentrations is not sensitive to using a complex chemistry model in MUNICH and the Leighton NO-NO2-O3 set of reactions is sufficient.

Multi-scale modeling of urban air pollution: development and application of a Street-in-Grid model (v1.0 by coupling MUNICH (v1.0 and Polair3D (v1.8.1

Directory of Open Access Journals (Sweden)

Y. Kim

2018-02-01

Full Text Available A new multi-scale model of urban air pollution is presented. This model combines a chemistry–transport model (CTM that includes a comprehensive treatment of atmospheric chemistry and transport on spatial scales down to 1 km and a street-network model that describes the atmospheric concentrations of pollutants in an urban street network. The street-network model is the Model of Urban Network of Intersecting Canyons and Highways (MUNICH, which consists of two main components: a street-canyon component and a street-intersection component. MUNICH is coupled to the Polair3D CTM of the Polyphemus air quality modeling platform to constitute the Street-in-Grid (SinG model. MUNICH is used to simulate the concentrations of the chemical species in the urban canopy, which is located in the lowest layer of Polair3D, and the simulation of pollutant concentrations above rooftops is performed with Polair3D. Interactions between MUNICH and Polair3D occur at roof level and depend on a vertical mass transfer coefficient that is a function of atmospheric turbulence. SinG is used to simulate the concentrations of nitrogen oxides (NOx and ozone (O3 in a Paris suburb. Simulated concentrations are compared to NOx concentrations measured at two monitoring stations within a street canyon. SinG shows better performance than MUNICH for nitrogen dioxide (NO2 concentrations. However, both SinG and MUNICH underestimate NOx. For the case study considered, the model performance for NOx concentrations is not sensitive to using a complex chemistry model in MUNICH and the Leighton NO–NO2–O3 set of reactions is sufficient.

Bernhard von Gudden, neuro-ophthalmology and the Munich School of Neuroanatomy and Psychiatry.

Science.gov (United States)

Danek, Adrian

2006-12-01

Bernhard von Gudden, psychiatrist to the Royal House of Bavaria (1824-1886), had studied ocular torsion by means of self-observation in the mirror and with the help of after-images for his dissertation of 1848, but later turned to experimental neuroanatomy. Several findings are connected with his name, among them the transverse peduncular tract, part of the accessory optic system. August Forel, Emil Kraepelin and Franz Nissl belonged to his Munich school that took neuroanatomical research as a guiding principle for scientific psychiatry.

The Munich Near-Infrared Cluster Survey - IX. Galaxy evolution to z ~ 2 from optically selected catalogues†‡

Science.gov (United States)

Feulner, Georg; Goranova, Yuliana; Hopp, Ulrich; Gabasch, Armin; Bender, Ralf; Botzler, Christine S.; Drory, Niv

2007-06-01

We present B-, R- and I-band-selected galaxy catalogues based on the Munich Near-Infrared Cluster Survey (MUNICS) which, together with the previously used K-selected sample, serve as an important probe of galaxy evolution in the redshift range 0 Karl-Schwarzschild Strasse 2, D-85748, Garching bei München, Germany.

Emergency planning of the city of Munich with reference to nuclear facilities, especially the nuclear power stations Isar I and II, resp. the reactor in Garching

International Nuclear Information System (INIS)

1990-01-01

During the hearing of Munich's city council of 13.7.1990 thirteen experts were heard on the following subjects: Hazard potential of Isar reactors and FRM reactor and appropriate radioactive waste transports; responsibilities in emergency planning. Some of the experts cannot visualize a major accident and propose not to cater for it. Shelters and evacuation are not planned for Munich, both solutions not being realizable for all inhabitants. Nuclear phaseout is seen by some as a measure of prevention. (HSCH) [de

[Max Isserlin, Kantian orientation at Königsberg, psychotherapist with Kraepelin, founder of child psychiatry at Munich, emigrant to Britain].

Science.gov (United States)

Peters, U H

2002-01-01

This account of the life and work of Max Isserlin (1879 - 1941) wants to be a reminder of a German-Jewish fate next to Kraepelin and as a forced emigrant. Immediately after his studies at Königsberg Isserlin in 1903 came to Kraepelin at Heidelberg, later he followed him to Munich. All his life he kept a Kantian orientation and defended Kraepelin's positions out of this background. Kraepelin entrusted to him all of psychotherapy, theory and practice, which Isserlin for at least 18 years gave courses of in Kraepelin's department. His textbook of psychotherapy thus transmissions Kraepelins convictions about this topic also. During World War I Isserlin was the head of a field-hospital for brain damaged soldiers and continued working this way after the end of the war. Finally he became the founder of child psychiatry in Munich, until he was forced to leave Germany for Britain with a heavy heart.

The third international meeting on genetic disorders in the RAS/MAPK pathway: towards a therapeutic approach.

Science.gov (United States)

Korf, Bruce; Ahmadian, Reza; Allanson, Judith; Aoki, Yoko; Bakker, Annette; Wright, Emma Burkitt; Denger, Brian; Elgersma, Ype; Gelb, Bruce D; Gripp, Karen W; Kerr, Bronwyn; Kontaridis, Maria; Lazaro, Conxi; Linardic, Corinne; Lozano, Reymundo; MacRae, Calum A; Messiaen, Ludwine; Mulero-Navarro, Sonia; Neel, Benjamin; Plotkin, Scott; Rauen, Katherine A; Roberts, Amy; Silva, Alcino J; Sittampalam, Sitta G; Zhang, Chao; Schoyer, Lisa

2015-08-01

"The Third International Meeting on Genetic Disorders in the RAS/MAPK Pathway: Towards a Therapeutic Approach" was held at the Renaissance Orlando at SeaWorld Hotel (August 2-4, 2013). Seventy-one physicians and scientists attended the meeting, and parallel meetings were held by patient advocacy groups (CFC International, Costello Syndrome Family Network, NF Network and Noonan Syndrome Foundation). Parent and patient advocates opened the meeting with a panel discussion to set the stage regarding their hopes and expectations for therapeutic advances. In keeping with the theme on therapeutic development, the sessions followed a progression from description of the phenotype and definition of therapeutic endpoints, to definition of genomic changes, to identification of therapeutic targets in the RAS/MAPK pathway, to preclinical drug development and testing, to clinical trials. These proceedings will review the major points of discussion. © 2015 Wiley Periodicals, Inc.

MEMS - Munich Energy Management System. FIA Project: Exchange of research information; MEMS - Muenchner Energiemanagement-System. FIA-Projekt - Forschungs-Informations-Austausch

Energy Technology Data Exchange (ETDEWEB)

Funk, H.; Fries, W.

2001-10-01

The City of Munich developed the project 'Munich Energy-Management-Systems (MEMS)' with financial support from the Federal Ministry of Economy and Technology. The project is based on a system of building automation using as many standard elements of hardware and software as possible. This will guarantee a high degree of independence from suppliers and subcontractors. The project has led to a reliable working base for the evaluation, measuring and control for ca. 150 municipal buildings. (orig.) [German] Mit dem Projekt 'Muenchner Energie-Management-System (MEMS)' erstellte die Landeshauptstadt Muenchen mit finanzieller Unterstuetzung des Bundesministeriums fuer Wirtschaft und Technologie ein auf der Leitzentrale Haustechnik (LZH) basierendes zentrales Energiemanagementsystem. Die Verwendung moeglichst vieler Standards in Hard- und Software ist dabei ein wesentlicher Gesichtspunkt. Dadurch wurde eine weitgehende Unabhaengigkeit von einem einzelnen Hersteller erreicht. Damit wurde ein Erfassungs-, Auswerte- und Steuerungssystem fuer derzeit rund 150 staedtische Gebaeude geschaffen. (orig.)

Munich Re konsultant Gerhard Berz : katastroofid on meie ärile kasulikud / Gerhard Berz ; interv. Ulrich Schnabel, tõlk. Erik Aru

Index Scriptorium Estoniae

Berz, Gerhard

2005-01-01

Intervjuu meteoroloogiga, kes on kolm aastakümmet arvutanud edasikindlustusfirma Munich Re heaks loodusõnnetuste riske ja viibinud ligi viiekümnes katastroofipiirkonnas. Vaatamata sellele, et 2004. aasta oli kõige kulukamate looduskatastroofide aasta, saavutas firma läbi aegade parimad majandustulemused. Lisa: Meeletu kahju

Munich case, some decisions make great stories: Business Model innovation by means of Social Media

OpenAIRE

Rodríguez Donaire, Silvia; Olivé Tomàs, Antoni

2012-01-01

The main objective of this article is to identify how Social Media influences the way the business is managed and/or innovated. To evaluate this Business Model Innovation we have conducted a case study that assesses how strategic choices made by managers, due to the implementation of Social Media, influences Business Model Innovation. The contribution of this article throughout the company’s history, Munich case, allows us to see how Munich’s Business Model has been innovated, and how Social ...

The EDP data base as a marketing instrument in the supply industry. Methods and experiences in natural gas customer acquisition of the Munich municipal utilities

International Nuclear Information System (INIS)

Wind, F.; Disser, U.

1994-01-01

The natural gas marketing concept of the Munich municipal utilities describes the aims and objectives for the acquisition of new customers beyond the year 2000. One target is to extend the grids into new areas but also activate natural gas clients in densely populated areas. The marketing strategies concentrate on extensive advice and consulting co-ordinated by the customer service representatives with the support of electronic data processing. The following report shows how modern database systems were integrated into marketing activities by the Munich municipal utility company and describes the strategies selected in new areas and areas with a high customer population. (orig.) [de

Patterns of suicidal behaviour in a metro subway system: a study of 306 cases injured by the Munich subway, 1980-1999.

Science.gov (United States)

Ladwig, Karl-Heinz; Baumert, Jens J

2004-09-01

As a basis for preventive strategies to reduce subway suicides, an investigation was undertaken to determine if there was a distinct pattern of subway suicidal behaviour. Data were taken from the Municipal Munich Subway System case registry (southern Germany) for all suicidal incidents on the track: purposely inflicted; date, time and location of incident, sex of victim, outcome. The analysis covered a 20 year observation period between 1980 and 1999, for which the Munich Municipal Office for Statistics also provided data of all deaths due to suicides within the city area of Munich. Suicide mortality was classified by the International Classification of Diseases, Ninth revision (codes E950-E959). A total of 306 incidents were documented with an annual mean of 16.5 cases. Case fatality was 66% (n=202). It was highest in winter and in higher aged groups. No significant time trend for incidences was observed. Median age of suicide attempters was 38 years. Most incidences (24.2%) were recorded for persons aged 20-29 years. The male: female ratio was 1.15 : 1. The peak time of day for incidences in women was during the late morning hours while significantly more men committed subway suicides during evening hours (p=0.001). No consistent seasonal variation was observed. In comparison to average suicide attempters, subjects committing subway suicides are markedly younger and they follow to a lesser extent established seasonal or circadian time patterns. More women are involved in subway suicides than would be expected. However, similarities to reports on behavioural patterns of subway suicides in other communities are striking.

Status of the compact core design for the Munich research reactor

International Nuclear Information System (INIS)

Boening, K.; Glaeser, W.; Meier, J.; Rau, G.; Roehrmoser, A.; Zhang, L.

1985-01-01

A novel 'compact core' has been proposed for our project of substantially modernizing the research reactor FRM at Munich. This core has about 20 cm diameter and 70 cm height, is cooled by H 2 O and surrounded by a large D 2 O moderator tank. It makes essential use of the new U 3 Si/Al dispersion fuel with very high Uranium density now available. We present the results of new, two-dimensional neutronic calculations and give an estimate of the probable burnup and reactivity behaviour of the compact core. We expect that this core can be effectively operated with an unperturbed multiplication factor of about 1.22, and that a maximum thermal neutron flux of 7 to 8·10 14 cm- ,2 s -1 can be achieved in the D 2 O tank at 20 MW reactor power. (author)

Philosophy of race meets population genetics.

Science.gov (United States)

Spencer, Quayshawn

2015-08-01

In this paper, I respond to four common semantic and metaphysical objections that philosophers of race have launched at scholars who interpret recent human genetic clustering results in population genetics as evidence for biological racial realism. I call these objections 'the discreteness objection', 'the visibility objection', 'the very important objection', and 'the objectively real objection.' After motivating each objection, I show that each one stems from implausible philosophical assumptions about the relevant meaning of 'race' or the nature of biological racial realism. In order to be constructive, I end by offering some advice for how we can productively critique attempts to defend biological racial realism based on recent human genetic clustering results. I also offer a clarification of the relevant human-population genetic research. Copyright © 2015 Elsevier Ltd. All rights reserved.

The Potential for Genetic Control of Malaria-Transmitting Mosquitoes. Report of a Consultants Group Meeting. Working Material

Energy Technology Data Exchange (ETDEWEB)

NONE

1993-07-01

Since the beginning of the Joint FAO/IAEA Division Programme on the research and development of insect pest control methodology, emphasis has been placed on the basic and applied aspects of implementing the Sterile Insect Technique (SIT). Special emphasis has always been directed at the assembly of technological progress into workable systems that can be implemented in developing countries. The general intention is to solve problems associated with insect pests that have an adverse impact on public health and the production of food and fibre. For certain insects, SIT has proven to be a powerful method for control, but for a variety of reasons this technology has not been tried on an operational scale for most of the pest species of insects that exact a toll on the endeavors of humans. The Joint FAO/IAEA Division convened a Consultants Group Meeting to examine 'The Potential for Genetic Control of Malaria-Transmitting Mosquitoes', with emphasis to be placed on the SIT. A group of five scientists met, 26-30 April 1993, to examine the current status and the future potential of genetic control for malaria mosquitoes. In most of the tropical, developing countries, and to some extent in temperate regions of the world, Anopheles mosquitoes cause havoc by transmitting malaria, a dreaded disease that causes high mortality amongst children and diminishes productivity of adults. The importance of malaria as a deterrent to further economic growth in a large part of the world cannot be over-emphasized. Malaria is a severe problem because there are inadequacies in the technology available for control. As a result of the deliberations at the meeting, the consultants prepared a list of recommendations concerning the consensus opinions about the development of genetic control for malaria vector control. This report presents the findings and recommendations of the Consultants Group Meeting.

The Potential for Genetic Control of Malaria-Transmitting Mosquitoes. Report of a Consultants Group Meeting. Working Material

International Nuclear Information System (INIS)

1993-01-01

Since the beginning of the Joint FAO/IAEA Division Programme on the research and development of insect pest control methodology, emphasis has been placed on the basic and applied aspects of implementing the Sterile Insect Technique (SIT). Special emphasis has always been directed at the assembly of technological progress into workable systems that can be implemented in developing countries. The general intention is to solve problems associated with insect pests that have an adverse impact on public health and the production of food and fibre. For certain insects, SIT has proven to be a powerful method for control, but for a variety of reasons this technology has not been tried on an operational scale for most of the pest species of insects that exact a toll on the endeavors of humans. The Joint FAO/IAEA Division convened a Consultants Group Meeting to examine 'The Potential for Genetic Control of Malaria-Transmitting Mosquitoes', with emphasis to be placed on the SIT. A group of five scientists met, 26-30 April 1993, to examine the current status and the future potential of genetic control for malaria mosquitoes. In most of the tropical, developing countries, and to some extent in temperate regions of the world, Anopheles mosquitoes cause havoc by transmitting malaria, a dreaded disease that causes high mortality amongst children and diminishes productivity of adults. The importance of malaria as a deterrent to further economic growth in a large part of the world cannot be over-emphasized. Malaria is a severe problem because there are inadequacies in the technology available for control. As a result of the deliberations at the meeting, the consultants prepared a list of recommendations concerning the consensus opinions about the development of genetic control for malaria vector control. This report presents the findings and recommendations of the Consultants Group Meeting.

Latest version of the Munich pulsed low energy positron system

International Nuclear Information System (INIS)

Bauer-Kugelmann, W.; Sperr, P.; Koegel, G.; Triftshaeuser, W.

2001-01-01

Further improvements of the Munich pulsed low energy positron system have been performed. A new chopper, configured as a double plate deflection system with an external resonator and a new buncher working like a classical double gap buncher, are implemented. The complete rf-power electronic was redesigned and operates now at an overall master-frequency of 50 MHz for all bunching and chopping components. A new target station with an enlarged Faraday cage is installed. The sample temperature is variable between 30 K and 600 K. Up to ten samples can be stored in a magazine and transferred under vacuum conditions to the measuring position. With a primary source of 30 mCi 22 Na a count rate of up to 4 kHz can be achieved with a peak-to-background ratio of 3000:1. This ratio can be further improved by the use of a Wien filter. A beam diameter of about 2 mm was determined. The total time resolution (pulsing plus detector system) is 250 ps (FWHM). (orig.)

75 FR 62406 - Plan To Develop a Genetic Testing Registry at the National Institutes of Health; Public Meeting...

Science.gov (United States)

2010-10-08

... informed decision making by patients, caregivers, health care professionals, clinical laboratory... of tests would be added later. If NIH adopts this approach, what criteria should be used to determine which genetic tests should be included in the first phase of the GTR, and what types of tests would meet...

Upgrading of the Munich reactor with a compact core

International Nuclear Information System (INIS)

Boening, K.; Glaeser, W.; Meier, J.; Rau, G.; Roehrmoser, A.; Zhang, L.

1985-01-01

An extremely small reactor core has been proposed for the project of substantial modernization of the FRM research reactor at Munich. According to the present status this 'compact core' will be a cylinder with a diameter of about 20 cm and 70 cm high. The new high-density U 3 Si/Al dispersion fuel of about 45% enrichment is contained in 20 concentric fuel plate rings. The compact core is surrounded by a large heavy-water tank which will incorporate the user installations (beam tubes and irradiation channels). However, the primary cooling circuit will contain light water which is not only more economic but also essential for the performance of the small core. An important optimization potential to decrease easily the power density peaks in the core is to reduce further the enrichment in those fuel plate rings where the neutron flux is particularly high. Two-dimensional neutron transport calculations show that such a core, containing about 7.5 kg 235 U, should have an effective multiplication factor of about 1.22 and an unperturbed but realistic maximum thermal neutron flux in the heavy water tank of 7 to 8x10 14 cm -2 .s -1 at 20 MW reactor power. (author)

The new high flux neutron source FRM-2 in Munich

International Nuclear Information System (INIS)

Roegler, H.J.; Wierheim, G.

2002-01-01

Quite some years ago in 1974 to be exact, the first consideration on a new neutron source started at the technical university of Munich (Germany). 27 years later the new high flux neutron source (FRM-2) was read for hot operation, now delayed by a refused approval for its third partial license by the federal government of Germany despite a wide support from the scientific community. FRM-2 is a tank-type research reactor cooled by water, moderated by heavy water and whose thermal power was limited to 20 MW maximum. The extreme compact core together with the applied inverse flux principle led to a neutron flux design value of 8.10 18 n/m 2 .s at the reflector peak. 10 beam tubes will allow an optimized use of the high neutron flux. A hot neutron source with graphite at about 2200 Celsius degrees and a cold neutron source with liquid D 2 at about 25 K will provide shifted energy spectra. The utilization of FRM-2 is many-fold: neutronography and tomography, medical irradiation, radio-nuclide production, doping of pure silicon, neutron activation analysis. (A.C.)

Status report of the Triton/Munich

International Nuclear Information System (INIS)

Trinks, U.

1988-01-01

At the Accelerator Laboratory of the Universities of Munich a booster for the existing MP-tandem is under construction. The Tritron project was finally funded in January this year. The Tritron is a cyclotron with separated orbits with both the magnets and cavities superconducting. It will increase the ion energies by a factor of 4.9, so a 12 C 6+ -beam will have a maximum energy of 21 MeV/u e.g. The cryostat has a diameter of 3.6 m. The beam is injected at a radius r 1 = 66 cm and extracted after almost 20 turns at r 2 = 145 cm. The turn separation is δR = 4 cm. The bending is made by 12 flat magnet sectors, each consisting of 20 magnetic channels of window frame type. In each channel the magnetic field (∼ 1.4 T) is adjustable individually, so that the beam always can be guided along the spiral orbit. The gradient is alternating from one sector to the next resulting in strong focusing in both transversal directions. In each second intermediate gap a wedge-shaped accelerating cavity of the reentrant type is installed for the 20 parallel beams. The radial cavity length is 1.2 m, the outside width 0.7 m. The radial length of the accelerating lips is 0.9 m, the gap width at injection radius 6 cm, at extraction radius 13 cm. The rf-frequency is ∼ 170 MHz, the maximum voltage at injection U(r 1 ) ≅ 270 kV, at extraction U(r 2 ) ≅ 540 kV per cavity. If the bunchers cross the cavity at a rf-phase with increasing accelerating voltage, they are focused longitudinally, resulting in ∼ 0.2 synchrotron oscillations per turn. The longitudinal focusing causes the rf-phase to change automatically corresponding to the necessary energy gain and to the radial characteristic of the voltage amplitude along the gap. 2 references, 6 figures, 1 table

Live cell imaging at the Munich ion microbeam SNAKE - a status report.

Science.gov (United States)

Drexler, Guido A; Siebenwirth, Christian; Drexler, Sophie E; Girst, Stefanie; Greubel, Christoph; Dollinger, Günther; Friedl, Anna A

2015-02-18

Ion microbeams are important tools in radiobiological research. Still, the worldwide number of ion microbeam facilities where biological experiments can be performed is limited. Even fewer facilities combine ion microirradiation with live-cell imaging to allow microscopic observation of cellular response reactions starting very fast after irradiation and continuing for many hours. At SNAKE, the ion microbeam facility at the Munich 14 MV tandem accelerator, a large variety of biological experiments are performed on a regular basis. Here, recent developments and ongoing research projects at the ion microbeam SNAKE are presented with specific emphasis on live-cell imaging experiments. An overview of the technical details of the setup is given, including examples of suitable biological samples. By ion beam focusing to submicrometer beam spot size and single ion detection it is possible to target subcellular structures with defined numbers of ions. Focusing of high numbers of ions to single spots allows studying the influence of high local damage density on recruitment of damage response proteins.

17th European photovoltaic solar energy conference and exhibition, Munich 22.-26.10.2001

International Nuclear Information System (INIS)

Nowak, S.

2002-01-01

This report for the Swiss Federal Office of Energy (SFOE) summarises the photovoltaics (PV) conference and exhibition held in Munich in October 2001 from the Swiss point of view. The contributions made by representatives of Swiss institutions and companies are presented including papers on the progress being made in third generation crystalline and multi-crystalline silicon technology, amorphous and micro-crystalline silicon solar cells, thin film solar cells based on compound semiconductors and thermo-photovoltaics. Further papers deal with PV modules on the market, building-integrated solar power systems and new developments in PV systems technology. The exhibition that accompanied the conference, including the 12 Swiss exhibitors who were present, is reviewed as are international market developments. Contributions concerning the application of photovoltaics in developing countries are also reviewed

Journal of Genetics | Indian Academy of Sciences

Indian Academy of Sciences (India)

... Scientific Data of Public Interest · Events · Annual Meetings · Mid Year Meetings · Discussion Meetings · Public Lectures · Lecture Workshops · Refresher Courses · Symposia · Live Streaming. Home; Journals; Journal of Genetics; Volume 81; Issue 1. The genetics of the dog. J. H. Edwards. Book review Volume 81 Issue 1 ...

ITER EDA newsletter. V. 4, no.12

International Nuclear Information System (INIS)

1995-12-01

This issue of the ITER EDA (Engineering Design Activities) Newsletter contains a report on the ninth ITER council meeting held December 12 - 13, 1995 in Garching near Munich, Germany (by Dr. E. Canobbio), a report on the status of the ITER EDA (by Dr. R. Aymar, ITER Director) and a report on the ninth meeting of the ITER Technical Advisory Committee (by Professor P. Rutherford, TAC Chair) held 27 - 29 November 1995, in Garching near Munich, Germany

A measurement based analysis of the spatial distribution, temporal variation and chemical composition of particulate matter in Munich and Augsburg

Directory of Open Access Journals (Sweden)

Klaus Schäfer

2011-02-01

Full Text Available The objective of the studies presented in this paper is to present an analysis of spatial distribution and temporal variation of particulate matter in Munich and Augsburg, Germany, and to identify and discuss the factors determining the aerosol pollution in both areas. Surface-based in-situ and remote sensing measurements of particle mass and particle size distribution have been performed in, around, and above the two cities. Two measurement campaigns were conducted in Munich, one in late spring and one in winter 2003. Another campaign has been on-going in Augsburg since 2004. Spatial and temporal variations are analyzed from this data (PM10, PM2.5, and PM1. There are higher particle mass concentrations at the urban site than at the surrounding rural sites, especially in winter. No significant difference in the major ionic composition of the particles between the urban and the rural site was detected. This is considered to be related to the spatial distribution of secondary inorganic aerosol that is more homogeneous than aerosol resulting from other sources like traffic or urban releases in general. During the measurement campaigns mixing layer heights were determined continuously by remote sensing (SODAR, ceilometer, RASS. Significant dependence of particle size distribution and particle mass concentration on mixing layer height was found. This finding paves the way to new applications of satellite remote sensing products.

Reanálisis del diagnóstico de alcoholismo en Perú: el test de alcoholismo Munich (malt

Directory of Open Access Journals (Sweden)

Klaus-Dieter Gorené

1992-12-01

Full Text Available El Test de Alcoholismo Munich (MALT fue traducido al español y aplicado a una muestra constituida por 145 probandos peruanos, de los cuales 94 eran alcohólicos. El MALT consta de dos partes: la primera está conformada por siete preguntas que son contestadas por el médico y la segunda sección está formada por 24 preguntas y son contestadas por el paciente. Tanto el coeficiente de validación para toda la prueba (r=0.87 como el coeficiente de confiabilidad de la parte autoadministrable (r=0.93 fueron elevados.

Development of a thermal hydraulic modelling of ground water of the Malm in the Munich metropolitan area; Entwicklung einer thermisch-hydraulischen Grundwassermodellierung des Malm im Grossraum Muenchen

Energy Technology Data Exchange (ETDEWEB)

Dussel, M.; Lueschen, E.; Thomas, R. [Leibniz-Institut fuer Angewandte Geophysik, Hannover (DE)] (and others)

2011-10-24

The mutual potential influence of geothermal duplicates and the scientific investigation of the relationship between seismic and hydraulic parameters are investigated in the joint research project 'Geothermal characterization of fractured karst limestone aquifers in the Munich metropolitan area'. Thirteen doublets and triplets being in production or sunk illustrate the great geothermal potential and provide important data on the development of a thermal-hydraulic modeling of the reservoir. 3D seismic Unterhaching, 3D structural model, hydrogeological model and a high-resolution 3D temperature model form the basis of the numerical modeling. Different seismic signatures, seismic attributes and variations in the interval velocities characterize the ground geophysically, and were interpreted under consideration of geological and hydrogeological background information as well as borehole measurements in terms of hydraulically conductive homogeneous areas. For the Munich metropolitan area, the numerical modeling is a decision aid for the future optimized and sustainable hydrothermal utilization of the Malm aquifer.

2007 Winter meeting - nuclear power in a relationship of tension between politics, society, and the economy

International Nuclear Information System (INIS)

Anon.

2007-01-01

Some 300 interested representatives of the power industry, industry at large, politics, administration, science and research met in Berlin on February 7 and 8, 2007 by invitation of the Deutsches Atomforum e.V. to exchange ideas and experience at the '2007 Winter Meeting'. This year's event was dedicated to the basic conditions underlying the use of nuclear power in Germany, Europe and worldwide. Seven contributions and statements by representatives from politics, industry, and society reflected a broad spectrum of divergent aspects and opinions about the topic of the meeting. Hans-Ulrich Joerges (stern, Berlin) chaired a discussion among Baerbel Hoehn (MP, Alliance 90/The Greens), Dr. Gerd Jaeger (RWE Power AG, Essen), Herbert Reul (MEP, energy policy spokesman of the CDU/CSU group of the European Parliament), and Prof. Dr.-Ing. Ulrich Wagner (Munich Technical University) about current and future aspects of power supply with or without nuclear energy. At the beginning of the year, the '2007 Winter Meeting' offered an interesting start of the debates accompanying this year's climate discussions, the problems associated with gas and oil deliveries from Russia, and the goal to adopt politically a sustainable energy program in the course of the year. (orig.)

Inclusion Criteria for NCI Cancer Genetics Services Directory

Science.gov (United States)

Professionals who provide services related to cancer genetics (cancer risk assessment, genetic counseling, genetic susceptibility testing, and others) must meet these criteria before applying to be listed in the National Cancer Institute's Cancer Genetics Services Directory.

Sanatorio para la infancia, en Munich

Directory of Open Access Journals (Sweden)

Haind, Friedrich F.

1964-10-01

Full Text Available The main objects to be met in the design this Children's Building were to provide suitable control and protection of the children, adequate working conditions for the nurses, and develop a pleasant family environment. This clinic is an extension of that run by the Sisters of Saint Benedict in Lechnerstrasse, Munich. It consists of two blocks, of 4 and 5 floor levels. It has a semibasement, housing the services, and some spare rooms and other facilities, described in the enclosed plans. The ground floor provides room for 25 beds, for the older boys. On the second floor there are 30 beds for those recently born, whilst the third floor has space for 30 beds for prematurely born babies. The nurses live in the attic, where there are 15 bedrooms, each with two beds, a kitchen and suitable auxiliary facilities. Much thought has been given to the design of details, the general distribution and circulation system has been planned with much care, and the overall functional efficiency of the building as a children's clinic has been kept a paramount factor. All this makes this building an outstanding one among those of this type.Los objetivos principales perseguidos aquí son: conseguir una eficaz vigilancia y protección de los niños; organizar los puestos de trabajo de las enfermeras para que resulten prácticos y agradables, y crear un ambiente familiar La clínica construida —como ampliación de las instalaciones que las Hermanas de San Benito poseen en la calle Lachner, en Munich— comprende dos cuerpos de edificio unidos, de 4 y 5 plantas de altura, respectivamente, y está distribuida del siguiente modo: el semisótano aloja, además de la zona de servicios, una serie de dependencias, que vienen descritas en la respectiva documentación gráfica. La planta baja alberga 25 camas; está destinada a los niños mayores y colegiales; la planta primera, con 30 camas, a los recién nacidos, y la planta segunda, con 30 camas, a la sección de prematuros

Inauguration of the cameroonian society of human genetics.

Science.gov (United States)

Wonkam, Ambroise; Kenfack, Marcel Azabji; Bigoga, Jude; Nkegoum, Blaise; Muna, Wali

2009-10-20

The conjunction of "hard genetics" research centers, with well established biomedical and bioethics research groups, and the exceptional possibility to hold the 6th annual meeting of the African Society of Human Genetics (AfSHG, 13th-15th March 2009) was an excellent opportunity to get together in synergy the entire Cameroonian "DNA/RNA scientists" . This laid to the foundation of the Cameroonian Society of Human Genetics (CSHG) that was privilege to hold its inaugural meeting in conjunction to the 6th annual meeting of the AfSHG. The theme was "Human Origin, Genetic Diversity and Health". The AfSHG and CSHG invited leading African and international scientists in genomics and population genetics to review recent data and provide an understanding of the state-of-knowledge of Human Origin and Genetic Diversity. Overall one opening ceremony eight session, five keynote and guest speakers, 18 invited oral communications, 13 free oral communications, 43 posters and two social events could summarize the meeting. This year's conference was graced by the presence of one Nobel Prize winner Dr Richard Roberts (Physiology and Medicine 1993). The meeting registered up to ten contributions of Cameroonian scientists from the Diaspora (currently in USA, Belgium, Gambia, Sudan and Zimbabwe). Such Diaspora participation is an opportunity to generate collaborations with home country scientists and ultimately turn the "brain drain" to "brain circulation" that could reduce the impact of the migration of health professional from Africa. Interestingly, the personal implication of the Cameroonian Ministry of Public Heath who opened the meeting in the presence of the Secretary General of the Ministry of Higher Education and a representative of the Ministry of Scientific Research and Innovation was a wonderful opportunity for advocacy of genetic issues at the decision-makers level. Beyond our expectation, a major promise of the Cameroonian government was the creation of the National Human

Live cell imaging at the Munich ion microbeam SNAKE – a status report

International Nuclear Information System (INIS)

Drexler, Guido A; Siebenwirth, Christian; Drexler, Sophie E; Girst, Stefanie; Greubel, Christoph; Dollinger, Günther; Friedl, Anna A

2015-01-01

Ion microbeams are important tools in radiobiological research. Still, the worldwide number of ion microbeam facilities where biological experiments can be performed is limited. Even fewer facilities combine ion microirradiation with live-cell imaging to allow microscopic observation of cellular response reactions starting very fast after irradiation and continuing for many hours. At SNAKE, the ion microbeam facility at the Munich 14 MV tandem accelerator, a large variety of biological experiments are performed on a regular basis. Here, recent developments and ongoing research projects at the ion microbeam SNAKE are presented with specific emphasis on live-cell imaging experiments. An overview of the technical details of the setup is given, including examples of suitable biological samples. By ion beam focusing to submicrometer beam spot size and single ion detection it is possible to target subcellular structures with defined numbers of ions. Focusing of high numbers of ions to single spots allows studying the influence of high local damage density on recruitment of damage response proteins. The online version of this article (doi:10.1186/s13014-015-0350-7) contains supplementary material, which is available to authorized users

Radioiodine therapy in patients with Graves' disease: Comparison of outcome between Freiburg and Munich

International Nuclear Information System (INIS)

Moser, E.; Dagres, E.; Blattmann, H.; Kreisig, T.; Mann, K.

1990-01-01

The aim on this paper was to compare the results of radioiodine therapy (RIT) in patients with Graves' disease treated at two different nuclear medicine departments, Freiburg (FR); Munich (M). A low dose concept applying 60-80 Gy provides only a moderate rate of success: FR (80 Gy): 80%; M (60 Gy): 54%. A dose of 150 Gy, however, succeeds in 81% of the FR-cases and in 86% of the M-cases. As a consequence, this 150 Gy approach has a higher incidence of post-treatment hypothyroidism: FR: 49%; M: 62%. As the rate of post-treatment hypothyroidism seems to be independent of the dose concept these early post-treatment numbers will increase by about 4% per year in all patients. Nevertheless, the high dose concept is recommended, because the aim of RIT is to remove hyperthyroidism reliably, as the surgeons have told us. A hypothyroidism after RIT of Graves' disease, however, is the lesser evil compared to remaining or recurrent hyperthyroidism since these patients can be treated with thyroid hormones without problems. (orig.) [de

Application of Next Generation Sequencing on Genetic Testing

DEFF Research Database (Denmark)

Li, Jian

The discovery of genetic factors behind increasing number of human diseases and the growth of education of genetic knowledge to the public make demands for genetic testing increase rapidly. However, traditional genetic testing methods cannot meet all kinds of the requirements. Next generation seq...

Inauguration of the Cameroonian Society of Human Genetics

Directory of Open Access Journals (Sweden)

Jude Bigoga

2009-10-01

Full Text Available The conjunction of “hard genetics” research centers, with well established biomedical and bioethics research groups, and the exceptional possibility to hold the 6th annual meeting of the African Society of Human Genetics (AfSHG, 13th-15th March 2009 was an excellent opportunity to get together in synergy the entire Cameroonian “DNA/RNA scientists” . This laid to the foundation of the Cameroonian Society of Human Genetics (CSHG that was privilege to hold its inaugural meeting in conjunction to the 6th annual meeting of the AfSHG. The theme was "Human Origin, Genetic Diversity and Health”. The AfSHG and CSHG invited leading African and international scientists in genomics and population genetics to review recent data and provide an understanding of the state-of-knowledge of Human Origin and Genetic Diversity. Overall one opening ceremony eight session, five keynote and guest speakers, 18 invited oral communications, 13 free oral communications, 43 posters and two social events could summarize the meeting. This year’s conference was graced by the presence of one Nobel Prize winner Dr Richard Roberts (Physiology and Medicine 1993. The meeting registered up to ten contributions of Cameroonian scientists from the Diaspora (currently in USA, Belgium, Gambia, Sudan and Zimbabwe. Such Diaspora participation is an opportunity to generate collaborations with home country scientists and ultimately turn the “brain drain” to “brain circulation” that could reduce the impact of the migration of health professional from Africa. Interestingly, the personal implication of the Cameroonian Ministry of Public Heath who opened the meeting in the presence of the Secretary General of the Ministry of Higher Education and a representative of the Ministry of Scientific Research and Innovation was a wonderful opportunity for advocacy of genetic issues at the decision-makers level. Beyond our expectation, a major promise of the Cameroonian government was

Baron von Zach's business relations with the Munich entrepreneur Joseph von Utzschneider (German Title: Geschäftsbeziehungen des Barons von Zach zu dem Münchner Unternehmer Joseph von Utzschneider)

Science.gov (United States)

Schneider, Ivo

The relationship between the astronomer von Zach on the one side and the entrepreneur Joseph von Utzschneider and his partner Georg von Reichenbach on the other dates presumably from the year 1807 when Zach spent two months in Munich. Already in the same year Zach had ordered an instrument for himself and began to solicit business for the institute of Reichenbach, Utzschneider, and Liebherr, which was founded in 1804. One of the clients canvassed by Zach was the director of the observatory in Naples Zuccari. Zuccari had ordered the whole equipment for the new observatory from this institute in 1813. The instruments for Naples, which were completed in 1814, were sent accompanied by Reichenbach by land and sea to their destination where Reichenbach supervised their setup. At that time Reichenbach had separated from Utzschneider who kept the optical institute in Benediktbeuern with his new partner Joseph von Fraunhofer whereas Reichenbach became owner of the mathematical-mechanical institute in Munich. For personal and economical reasons Utzschneider began soon after to produce not only optical glass but also optical devices similar to those offered by Reichenbach. As soon as two institutes in Munich competed against each other on the market for sophisticated geodetical and astronomical instruments Zach sided with Utzschneider. Zach's main professional argument for this decision was that both competitors got the optical glass for their instruments from Utzschneider's optical institute in Benediktbeuern. This meant that Utzschneider had first choice and so the optical part of his instruments could be considered as better than that of Reichenbach`s instruments. Zach's role as an agent in Italy and France for the sale of products coming from Utzschneider's manufactories is highlighted by three of Zach's letters to Utzschneider from 1817 and 1818, two of which are reproduced here for the first time.

Genetics and molecular biology of breast cancer

Energy Technology Data Exchange (ETDEWEB)

King, M.C. [California Univ., Berkeley, CA (United States); Lippman, M. [Georgetown Univ. Medical Center, Washington, DC (United States)] [comps.

1992-12-31

This volume contains the abstracts of oral presentations and poster sessions presented at the Cold Springs Harbor Meeting on Cancer Cells, this meeting entitled Genetics and Molecular Biology of Breast Cancer.

Consumption Patterns of Nightlife Attendees in Munich: A Latent-Class Analysis.

Science.gov (United States)

Hannemann, Tessa-Virginia; Kraus, Ludwig; Piontek, Daniela

2017-09-19

The affinity for substance use among patrons of nightclubs has been well established. With novel psychoactive substances (NPS) quickly emerging on the European drug market, trends, and patterns of use are potentially changing. (1) The detection of subgroups of consumers in the electronic dance music scene of a major German metropolitan city, (2) describing the consumption patterns of these subgroups, (3) exploring the prevalence and type of NPS consumption in this population at nightlife events in Munich. A total of 1571 patrons answered questions regarding their own substance use and the emergence of NPS as well as their experience with these substances. A latent class analysis was employed to detect consumption patterns within the sample. A four class model was determined reflecting different consumption patterns: the conservative class (34.9%) whose substance was limited to cannabis; the traditional class (36.6%) which especially consumed traditional club drugs; the psychedelic class (17.5%) which, in addition to traditional club drugs also consumed psychedelic drugs; and an unselective class (10.9%) which displayed the greatest likelihood of consumption of all assessed drugs. "Smoking mixtures" and methylone were the new substances mentioned most often, the number of substances mentioned differed between latent classes. Specific strategies are needed to reduce harm in those displaying the riskiest substance use. Although NPS use is still a fringe phenomenon its prevalence is greater in this subpopulation than in the general population, especially among users in the high-risk unselective class.

Generation of a high-brightness pulsed positron beam for the Munich scanning positron microscope

Energy Technology Data Exchange (ETDEWEB)

Piochacz, Christian

2009-11-20

Within the present work the prerequisites for the operation of the Munich scanning positron microscope (SPM) at the high intense neutron induced positron source Munich (NEPOMUC) were established. This was accomplished in two steps: Firstly, a re-moderation device was installed at the positron beam facility NEPOMUC, which enhances the brightness of the positron beam for all connected experiments. The second step was the design, set up and initial operation of the SPM interface for the high efficient conversion of the continuous beam into a bunched beam. The in-pile positron source NEPOMUC creates a positron beam with a diameter of typically 7 mm, a kinetic energy of 1 keV and an energy spread of 50 eV. The NEPOMUC re-moderator generates from this beam a low energy positron beam (20 - 200 eV) with a diameter of less than 2 mm and an energy spread well below 2.5 eV. This was achieved with an excellent total efficiency of 6.55{+-}0.25 %. The re-moderator was not only the rst step to implement the SPM at NEPOMUc, it enables also the operation of the pulsed low energy positron beam system (PLEPS). Within the present work, at this spectrometer rst positron lifetime measurements were performed, which revealed the defect types of an ion irradiated uranium molybdenum alloy. Moreover, the instruments which were already connected to the positron beam facility bene ts considerably of the high brightness enhancement. In the new SPM interface an additional re-moderation stage enhances the brightness of the beam even more and will enable positron lifetime measurements at the SPM with a lateral resolution below 1 {mu}m. The efficiency of the re-moderation process in this second stage was 24.5{+-}4.5 %. In order to convert high efficiently the continuous positron beam into a pulsed beam with a repetition rate of 50 MHz and a pulse duration of less than 50 ps, a sub-harmonic pre-bucher was combined with two sine wave bunchers. Furthermore, the additional re-moderation stage of the

Generation of a high-brightness pulsed positron beam for the Munich scanning positron microscope

International Nuclear Information System (INIS)

Piochacz, Christian

2009-01-01

Within the present work the prerequisites for the operation of the Munich scanning positron microscope (SPM) at the high intense neutron induced positron source Munich (NEPOMUC) were established. This was accomplished in two steps: Firstly, a re-moderation device was installed at the positron beam facility NEPOMUC, which enhances the brightness of the positron beam for all connected experiments. The second step was the design, set up and initial operation of the SPM interface for the high efficient conversion of the continuous beam into a bunched beam. The in-pile positron source NEPOMUC creates a positron beam with a diameter of typically 7 mm, a kinetic energy of 1 keV and an energy spread of 50 eV. The NEPOMUC re-moderator generates from this beam a low energy positron beam (20 - 200 eV) with a diameter of less than 2 mm and an energy spread well below 2.5 eV. This was achieved with an excellent total efficiency of 6.55±0.25 %. The re-moderator was not only the rst step to implement the SPM at NEPOMUc, it enables also the operation of the pulsed low energy positron beam system (PLEPS). Within the present work, at this spectrometer rst positron lifetime measurements were performed, which revealed the defect types of an ion irradiated uranium molybdenum alloy. Moreover, the instruments which were already connected to the positron beam facility bene ts considerably of the high brightness enhancement. In the new SPM interface an additional re-moderation stage enhances the brightness of the beam even more and will enable positron lifetime measurements at the SPM with a lateral resolution below 1 μm. The efficiency of the re-moderation process in this second stage was 24.5±4.5 %. In order to convert high efficiently the continuous positron beam into a pulsed beam with a repetition rate of 50 MHz and a pulse duration of less than 50 ps, a sub-harmonic pre-bucher was combined with two sine wave bunchers. Furthermore, the additional re-moderation stage of the SPM

FASEB Summer Research Conference. Genetic Recombination and Chromosome Rearrangements

Energy Technology Data Exchange (ETDEWEB)

Jinks-Robertson, Sue

2002-02-01

The 2001 meeting entitled ''Genetic Recombination and Genome Rearrangements'' was held July 21-26 in Snowmass, Colorado. The goal of the meeting was to bring together scientists using diverse approaches to study all aspects of genetic recombination. This goal was achieved by integrating talks covering the genetics, biochemistry and structural biology of homologous recombination, site-specific recombination, and nonhomologous recombination. The format of the meeting consisted of a keynote address on the opening evening, two formal plenary sessions on each of the four full meeting days, a single afternoon workshop consisting of short talks chosen from among submitted abstracts, and afternoon poster sessions on each of the four full meeting days. The eight plenary session were entitled: (1) Recombination Mechanisms, (2) Prokaryotic Recombination, (3) Repair and Recombination, (4) Site-specific Recombination and Transposition, (5) Eukaryotic Recombination I, (6) Genome Rearrangements, (7) Meiosis, and (8) Eukaryotic Recombination II. Each session included a mix of genetic, biochemical and structural talks; talks were limited to 20 minutes, followed by 10 minutes of very lively, general discussion. Much of the data presented in the plenary sessions was unpublished, thus providing attendees with the most up-to-date knowledge of this rapidly-moving field.

Journal of Genetics | Indian Academy of Sciences

Indian Academy of Sciences (India)

Annual Meetings · Mid Year Meetings · Discussion Meetings · Public Lectures · Lecture Workshops · Refresher Courses · Symposia · Live Streaming. Home; Journals; Journal of Genetics; Volume 94; Issue 2. Cloning and characterization of novel fast ω -gliadin genes in Triticum monococcum. Xuye Du Jinglan Zhao Xin Ma ...

Man-made radioactivity of surface air and precipitation Munich-Neuherberg 1970-1975

International Nuclear Information System (INIS)

Hoetzl, H.; Rosner, G.; Winkler, R.

1976-07-01

The activity concentration of a number of artificial radionuclides and of Be 7 in surface air and the deposition of these nuclides to the ground by the precipitation is measured since 1970 resp. 1971 at Neuherberg near Munich. Air dust filters are compressed to give a pellet and precipitation is evaporated to a small volume before γ-spectrometry using a Ge(Li)-detector. After ashing of the samples Pusup(238, 239, 240) and Fe 55 are separated radiochemically and measured by alpha respectively X-ray spectrometry. The results, presented as monthly mean resp. sum values, are discussed and compared with results published by other authors (HASL, UKAEA, PTB, DWD a.o.). The contribution of artificial radioactivity to the radiation exposure from fallout nuclides during the years 1970 to 1975 was very low. Their concentration levels led to values of the annual intake, which are far beyond the admissible values according to the new Radiation Protection Ordinance of the FRG. With regard to the intake by inhalation Pu 239 is the most important of all observed nuclides, whereas in the case of ingestion Sr 90 is the critical nuclide. At this time the level of the activity concentration is mainly represented by the residual radioactivity from nuclear bomb tests. A continuous control is necessary because of the growth of nuclear power production and the increasing use of radionuclides. (orig.) [de

The 50th Annual Maize Genetics Conference

Energy Technology Data Exchange (ETDEWEB)

Cone, Karen

2014-03-26

The 50th Annual Maize Genetics Conference was held February 27 - March 2, 2008 at the Marriott Wardman Park Hotel in Washington, D.C. As the golden anniversary of the Conference and coinciding with the release of a draft of the maize genome sequence, this was a special meeting. To publicize this unique occasion, meeting organizers hosted a press conference, which was attended by members of the press representing science and non-science publications, and an evening reception at the Smithsonian National Museum of Natural History, where the draft sequence was announced and awards were presented to Dr. Mary Clutter and Senator Kit Bond to thank them for their outstanding contributions to maize genetics and genomics research. As usual, the Conference provided an invigorating forum for exchange of recent research results in many areas of maize genetics, e.g., cytogenetics, development, molecular genetics, transposable element biology, biochemical genetics, and genomics. Results were shared via both oral and poster presentations. Invited talks were given by four distinguished geneticists: Vicki Chandler, University of Arizona; John Doebley, University of Wisconsin; Susan Wessler, University of Georgia; and Richard Wilson, Washington University. There were 46 short talks and 241 poster presentations. The Conference was attended by over 500 participants. This included a large number of first-time participants in the meeting and an increasingly visible presence by individuals from underrepresented groups. Although we do not have concrete counts, there seem to be more African American, African and Hispanic/Latino attendees coming to the meeting than in years past. In addition, this meeting attracted many participants from outside the U.S. Student participation continues to be hallmark of the spirit of free exchange and cooperation characteristic of the maize genetics community. With the generous support provided by DOE, USDA NSF, and corporate/private donors, organizers were

Journal of Genetics | Indian Academy of Sciences

Indian Academy of Sciences (India)

Annual Meetings · Mid Year Meetings · Discussion Meetings · Public Lectures · Lecture Workshops · Refresher Courses · Symposia · Live Streaming. Home; Journals; Journal of Genetics; Volume 87; Issue 2. Issue front cover thumbnail. Volume 87, Issue 2. August 2008, pages 99-200. pp 99-99 Editorial. Note on plagiarism.

Consultants' Group Meeting on Tsetse Genetics in Relation to Tsetse/Trypanosomiasis Control/Eradication

Energy Technology Data Exchange (ETDEWEB)

NONE

1992-07-01

The FAO and IAEA have long recognized the need for methods for insect and pest control based upon approaches other than simply the widespread use of insecticides. Through the past several years the Joint FAO/IAEA Division of Nuclear Techniques in Food and Agriculture has expended a considerable amount of effort in the development of a SIT programme applicable to tsetse. Such programmes have proved to be a highly successful component of the integrated control of tsetse flies. However, the pilot programmes undertaken to date have been applied to areas of limited size and future integrated control programmes for tsetse must cover much larger regions. The Consultants' Group was cognisant of the continued need for improvements in the cost effectiveness in the mass production of tsetse, particularly for SIT programmes. The Consultants' Goup recognized also that FAO/IAEA plays an important leadership role in the development of new technologies for the control of insect pest populations, and in the transfer of such technologies to assist in the improvement of agricultural production, particularly in developing countries. In addition to research on the development of methods for insect control (emphasizing application of the Sterile Insect Technique), the Joint FAO/IAEA Division of Nuclear Techniques in Food and Agriculture has established and implemented five 'Co-ordinated Research Programmes' on tsetse and has, from time to time, convened groups of consultants to discuss and make recommendations on specific subjects. At least two such meetings (in July 1975 and November 1987) focused on genetic methods of insect control. The recent, rapid developments in molecular biology have stimulated interest in the application of genetic techniques to the problem of tsetse and trypanosomiasis control in Africa.

Consultants' Group Meeting on Tsetse Genetics in Relation to Tsetse/Trypanosomiasis Control/Eradication

International Nuclear Information System (INIS)

1992-01-01

The FAO and IAEA have long recognized the need for methods for insect and pest control based upon approaches other than simply the widespread use of insecticides. Through the past several years the Joint FAO/IAEA Division of Nuclear Techniques in Food and Agriculture has expended a considerable amount of effort in the development of a SIT programme applicable to tsetse. Such programmes have proved to be a highly successful component of the integrated control of tsetse flies. However, the pilot programmes undertaken to date have been applied to areas of limited size and future integrated control programmes for tsetse must cover much larger regions. The Consultants' Group was cognisant of the continued need for improvements in the cost effectiveness in the mass production of tsetse, particularly for SIT programmes. The Consultants' Goup recognized also that FAO/IAEA plays an important leadership role in the development of new technologies for the control of insect pest populations, and in the transfer of such technologies to assist in the improvement of agricultural production, particularly in developing countries. In addition to research on the development of methods for insect control (emphasizing application of the Sterile Insect Technique), the Joint FAO/IAEA Division of Nuclear Techniques in Food and Agriculture has established and implemented five 'Co-ordinated Research Programmes' on tsetse and has, from time to time, convened groups of consultants to discuss and make recommendations on specific subjects. At least two such meetings (in July 1975 and November 1987) focused on genetic methods of insect control. The recent, rapid developments in molecular biology have stimulated interest in the application of genetic techniques to the problem of tsetse and trypanosomiasis control in Africa.

Next-generation sequencing meets genetic diagnostics: development of a comprehensive workflow for the analysis of BRCA1 and BRCA2 genes

Science.gov (United States)

Feliubadaló, Lídia; Lopez-Doriga, Adriana; Castellsagué, Ester; del Valle, Jesús; Menéndez, Mireia; Tornero, Eva; Montes, Eva; Cuesta, Raquel; Gómez, Carolina; Campos, Olga; Pineda, Marta; González, Sara; Moreno, Victor; Brunet, Joan; Blanco, Ignacio; Serra, Eduard; Capellá, Gabriel; Lázaro, Conxi

2013-01-01

Next-generation sequencing (NGS) is changing genetic diagnosis due to its huge sequencing capacity and cost-effectiveness. The aim of this study was to develop an NGS-based workflow for routine diagnostics for hereditary breast and ovarian cancer syndrome (HBOCS), to improve genetic testing for BRCA1 and BRCA2. A NGS-based workflow was designed using BRCA MASTR kit amplicon libraries followed by GS Junior pyrosequencing. Data analysis combined Variant Identification Pipeline freely available software and ad hoc R scripts, including a cascade of filters to generate coverage and variant calling reports. A BRCA homopolymer assay was performed in parallel. A research scheme was designed in two parts. A Training Set of 28 DNA samples containing 23 unique pathogenic mutations and 213 other variants (33 unique) was used. The workflow was validated in a set of 14 samples from HBOCS families in parallel with the current diagnostic workflow (Validation Set). The NGS-based workflow developed permitted the identification of all pathogenic mutations and genetic variants, including those located in or close to homopolymers. The use of NGS for detecting copy-number alterations was also investigated. The workflow meets the sensitivity and specificity requirements for the genetic diagnosis of HBOCS and improves on the cost-effectiveness of current approaches. PMID:23249957

Proceedings

International Nuclear Information System (INIS)

1974-01-01

These 1974 Proceedings of the European Society of Nuclear Methods in Agriculture contain reports in the form of minutes of the meetings of various working groups of the Society, the programme and official addresses of the fifth annual meeting including annual reports of the chairman and the secretary of the Society, and the reports of each of the eleven working groups as well as the four following surveys entitled: 1) some aspects of research in plant breeding, conservation of genetic resources in connection with irradiation processes (by A. Jacques from FAO), 2) our responsibility for the environment (by D. Zeeuw from ITAL), 3) pilot plant for the irradiation of sewage sludge (by A. Suesz from Bayerische Landesanstalt fuer Bodenkultur und Pflanzenbau, Munich), 4) nuclear agronomy in France (by P. Guerin de Montgareuil from CEN, Cadarache). Summaries and provisional papers on presented topics will be published in ''ESNA Newsletter''

Pathways and barriers to genetic testing and screening: Molecular genetics meets the high-risk family. Final report

Energy Technology Data Exchange (ETDEWEB)

Duster, T.

1998-11-01

The proliferation of genetic screening and testing is requiring increasing numbers of Americans to integrate genetic knowledge and interventions into their family life and personal experience. This study examines the social processes that occur as families at risk for two of the most common autosomal recessive diseases, sickle cell disease (SC) and cystic fibrosis (CF), encounter genetic testing. Each of these diseases is found primarily in a different ethnic/racial group (CF in Americans of North European descent and SC in Americans of West African descent). This has permitted them to have a certain additional lens on the role of culture in integrating genetic testing into family life and reproductive planning. A third type of genetic disorder, the thalassemias was added to the sample in order to extent the comparative frame and to include other ethnic and racial groups.

The history and development of the Human Genetics Society of Australasia.

Science.gov (United States)

Sutherland, Grant R

2008-08-01

The Human Genetics Society of Australasia is a vibrant professional society with more than 900 members that promotes and regulates the practice of human and medical genetics in Australia and New Zealand. The growth of human genetics was stimulated by the development of diagnostic clinical cytogenetics laboratories in the early to mid 1960s. This coincided with the recognition by medical specialists, mainly pediatricians, that genetic disorders, especially inborn errors of metabolism and birth defects, were of clinical interest and potentially challenging areas for their skills. The organization of professionals in human genetics was slow to evolve. There was an early Western Australian Human Genetics Society, and the cytogenetics community had begun to meet annually from about 1966 but was coordinated by a mailing list rather than as a formal organization. In 1976, as part of the celebrations of the Centenary Year of the Adelaide Children's Hospital, a clinical genetics meeting involving several high profile international speakers and most of the senior medical geneticists in Australia and New Zealand along with the annual meeting of the loose-knit cytogeneticists group agreed that a small working group be charged with setting up a Human Genetics Society. The society was formally incorporated in South Australia in 1977.

Munich Music Questionnaire: adaptation into Brazilian Portuguese and application in cochlear implant users.

Science.gov (United States)

Frederigue-Lopes, Natália Barreto; Bevilacqua, Maria Cecilia; Costa, Orozimbo Alves

2015-01-01

To translate the Munich Music Questionnaire (MUMU) to Brazilian Portuguese, to adapt it culturally, and to describe the results obtained among adult users of cochlear implant (CI). We translated the questionnaire to Brazilian Portuguese, reviewed the grammatical and idiomatic equivalences (back-translation), and adapted it from a linguistic and cultural perspective. The resulting version of this process was applied among adult CI users through direct interviews. The Brazilian Portuguese version of MUMU was applied to 19 adult CI users with postlingual hearing loss, who had been users of the device for at least one year. The answers to the questionnaire were analyzed by distribution of frequency and percentage of occurrence in each question. The results showed a decrease in the frequency of CI users that listen to music, comparing the period before hearing loss and after the CI. Regarding the role that music played in the life of each participant, the responses did not score change, so the music remained being an important factor in the life of the evaluated subjects, even after the CI. The subjective evaluation tool MUMU was translated and culturally adapted to the population studied. In Brazilian Portuguese, it was called Questionário de Música de Munique. The study showed its applicability in the daily monitoring of CI users, thus providing a profile of the activities related to music in everyday life.

Carcinoma basocelular simulando tumor intranasal: tratamento com cirurgia micrográfica pelo método de Munique Basal cell carcinoma mimicking intranasal tumor: treatment by Munich method of micrographic surgery

Directory of Open Access Journals (Sweden)

Luis Fernando Figueiredo Kopke

2007-12-01

Full Text Available Relata-se caso incomum de carcinoma basocelular que simulava tumor intranasal de crescimento expansivo, na cavidade da narina esquerda. Operado com cirurgia micrográfica pelo método de Munique, foi possível demonstrar que o tumor se originava da pele aparentemente normal e suprajacente do nariz. Por ser tridimensional, esse método de cirurgia micrográfica permite estudo mais preciso da peça cirúrgica. Discutem-se também aspectos peculiares da cirurgia micrográfica pelo método de Munique, o que contribui para a ampliação do conceito das cirurgias microscopicamente controladas.A rare case of basal cell carcinoma mimicking an expansive intranasal tumor in the left nostril is reported. Through the Munich micrographic surgery method, it was possible to demonstrate that the tumor originated from the apparently normal nose skin. Since this micrographic surgery is a tri-dimensional method, it enables a more accurate study of the specimen. Some peculiar aspects of the micrographic surgery using the Munich method are discussed, thus contributing to further understanding about the concept of microscopically controlled surgeries.

76 FR 18227 - Molecular and Clinical Genetics Panel of the Medical Devices Advisory Committee; Notice of...

Science.gov (United States)

2011-04-01

...] Molecular and Clinical Genetics Panel of the Medical Devices Advisory Committee; Notice of Meeting... comment period for the notice announcing a meeting of the Molecular and Clinical Genetics Panel (the panel... Clinical Genetics Panel of the Medical Devices Advisory Committee, and the opening of a public docket to...

Participation in interdisciplinary meetings on genetic diagnostics (NGS)

NARCIS (Netherlands)

Koole, Tom; van Burgsteden, Lotte; Harms, Paulien; van Diemen, Cleo C; van Langen, Irene M

2017-01-01

Diagnostics using next generation sequencing (NGS) requires high-quality interdisciplinary collaboration. In order to gain insight into this crucial collaborative process, we made video recordings of a new multidisciplinary team at work in the clinical genetics department of the University Medical

Global Political Aspects of Putin’s Speech at the 43-th Munich Security Conference. One Decade Past

Directory of Open Access Journals (Sweden)

Николай Петрович Пархитько

2018-12-01

Full Text Available In February 10th 2007 President of Russia V. Putin held a speech at the 43th Munich Security Conference. The speech included both the matters of security and global policy. Researchers in Russia together as well as their western colleagues (political scientists, journalists, historians and other analysts obviously came to the same opinion - that was the speech of the Russian president that attracted all the attention to this annual conference not being so traditionally popular as, for example, the “G-8” or the APEC summits. And though the estimations of the ideas advocated by Putin in his speech predictably differ depending on political creed and engagement of the analysts (sometimes that was also the matter of their erudition, the importance of the event was undisputable. Today one decade past the event we have the opportunity not just to analyze the crucial principles which Putin tried to clarify to his foreign partners, but also to verify them through the prism of approbation, as the scientists say. But before we start to study the speech itself, we should reveal the global political circumstances, in which the Conference took place. What was Russia as a global power in the beginning of the XXI century and was it a true global power in 2007? Was the political weight of the Russian president enough for bringing the influence into the world? Finally, what was the perceptions of Russia in the western community 15 years after the greatest transformation of the global political role of the country in Europe and in the world? After finding the answers on these questions we will reveal the main theses of the Russian presidents’ speech and will try to give them possibly candid estimation. In the work the authors used a wide methodological list. The historical-analytical method made it possible to reveal the evolution of the problems outlined in the speech of V.V. Putin for the specified time period (10 years. The comparative method allowed us

Inauguration of the Cameroonian Society of Human Genetics ...

African Journals Online (AJOL)

CSHG) that was privilege to hold its inaugural meeting in conjunction to the 6th annual meeting of the AfSHG. The theme was "Human Origin, Genetic Diversity and Health”. The AfSHG and CSHG invited leading African and international scientists in ...

Measurements of transuranium nuclides in the environment at the Institute for Radiation Protection of the Gessellschaft fuer Strehlen-und Umweltforschung mbH, Munich

International Nuclear Information System (INIS)

Rosner, G.; Hoetzl, H.; Winkler, R.

1978-01-01

Work on environmental transuranium nuclides at the Institute for Radiation Protection of the Gesellschaft fur Strahlen-und Umweltforschung mbH, Munich, is briefly described and standard needs are discussed. Fallout plutonium measurements in air dust and precipitation samples started in 1970/1971. The procedure is outlined and results are presented as annual mean and sum values, respectively. Since 1973, transuranium nuclides in primary coolant, stack effluent air and waste-water samples from nuclear power stations are measured. Nuclides detected are 239 240 Pu, 238 Pu and/or 241 Am, 242 Cm and 244 Cm. Examples of alpha particle spectra are given. Needs for standards in environmental transuranium analysis are discussed. (author)

A high intensity Stern-Gerlach polarized hydrogen source for the Munich MP-Tandem laboratory using ECR ionization and charge exchange in cesium vapor

International Nuclear Information System (INIS)

Hertenberger, R.; Eisermann, Y.; Metz, A.; Schiemenz, P.; Graw, G.

2001-01-01

The 14 year old Lamb-Shift hydrogen source of the Munich Tandem laboratory is presently replaced by a newly developed Stern-Gerlach type atomic beam source (ABS) with electron-cyclotron-resonance (ECR) ionization and subsequent double charge exchange in a supersonic cesium vapor jet target. The atomic beam source provides an intensity of 6.4*10 16 atoms/sec of polarized hydrogen and of about 5*10 16 atoms/sec of polarized deuterium. Beam intensities larger than 100 μA were observed for positive H-vector + and D-vector + ion beams after ECR ionization and intensities larger than 10 μA for negative D-vector - ion beams in three magnetic substates

Safe production and application of hydrogen at Munich airport

Energy Technology Data Exchange (ETDEWEB)

Szamer, R.

2005-07-01

At Munich International Airport the world's first public filling station for liquid and gaseous hydrogen with on-site hydrogen gas production has been installed. In order to prove the safety, liability and economic feasibility of hydrogen this pilot project examined the complete sequence of hydrogen production and application: on-site production with pressurized electrolyser and steam reformer, storage and filling of gaseous and liquid hydrogen, application of hydrogen for propelling several vehicles, e.g. airport busses in day to day operation, cars, fork lifter. TUV SUD Group, one of the largest service provider for technical safety and quality, was involved in the safety evaluation of the hydrogen project from the very beginning with the following services: safety consultancy throughout all project phases, e.g. for licensing procedures, plant design and operation safety analysis of the overall plant and of subsystems (electrolyser, filling stations, storage tanks, control systems etc.) safety assessment and acceptance testing of CH2 busses, CH2 fork lifter and LH2 passenger cars inspections and tests The challenges of this complex project relating to safety will be presented in the lecture, e.g. identification of potential hazards, safety requirements for the design and operation of the hydrogen plant as wells as for the various applications. Project description The hydrogen plant (cf. Figure 1) comprises two supply paths, one for compressed gaseous hydrogen (CH2) and one for cryogenic liquid hydrogen. Gaseous hydrogen is produced via high-pressure electrolysis at an operating pressure of 3 MPa (30 bar) and/or steam reforming process. The hydrogen will be led into a compressor, compressed to 35 MPa (350 bar) and stored in high pressure cylinders with a total geometrical storage volume of 10 m. The cylinders supply the high-pressure filling stations which refuels the 3 hydrogen buses and the fork lifter. Liquid hydrogen (LH2) is delivered in tank trucks and

Consultants Group Meeting on Genetic Sexing and Population Genetics of Screwworms. Working Material

International Nuclear Information System (INIS)

2000-01-01

A Thematic Plan on SIT for Screwworms developed in 1999 by IPC and TC identified certain R and D bottlenecks to the expansion of this technology into new agricultural areas. This consultant's meeting was held to review these conclusions and to advise the Agency on the need, or otherwise, of initiating a CRP to address the bottlenecks identified in the Thematic Plan. In 2001 it is expected that the New World Screwworm, Cochliomyia hominivorax, will have been eradicated from all of Central America, including Panama where a sterile release barrier will be established to prevent re-invasion from South America. This barrier will need to be maintained indefinitely with its associated costs. The use of an all-male strain in the production facility would have very positive impact on the cost/benefit analysis of the programme. The Director of the Screwworm Programme in Central America made this point very strongly during the Thematic Plan discussions and at a subsequent technical meeting in Tuxtla Gutierrez. Interest to expand the programme into South America is now being shown by certain countries in the region where the economic feasibility of implementing an SIT programme might depend on producing sterile flies more economically and here again the use of a genetic sexing strain could play an important role. For the Old World Screwworm, Chrysomya bezziana the Australian authorities have just completed a successful small field trial of the SIT in Malaysia and it is proposed that more extensive field tests be carried out in the region. For both the New World Screwworm in South America and the Old World Screwworm, in Asia there is virtually no information regarding the population structure in relation to the implementation of an SIT programme. Is the Old World Screwworm a single species over its very wide distribution and are the populations of New World Screwworm in South America the same as in Central America and related to each other? Are the populations isolated? These

Genetic basis and detection of unintended effects in genetically modified crop plants

NARCIS (Netherlands)

Ladics, G.S.; Bartholomaeus, A.; Bregitzer, P.; Doerrer, N.G.; Gray, A.; Holzhauzer, T.; Jordan, M.; Keese, P.; Kok, E.J.; Macdonald, P.; Parrott, W.; Privalle, L.; Raybould, A.; Rhee, S.Y.; Rice, E.; Romeis, J.; Vaughn, J.; Wal, J.M.; Glenn, K.

2015-01-01

In January 2014, an international meeting sponsored by the International Life Sciences Institute/Health and Environmental Sciences Institute and the Canadian Food Inspection Agency titled “Genetic Basis of Unintended Effects in Modified Plants” was held in Ottawa, Canada, bringing together over 75

ESNA: European Society for New Methods in Agricultural Research. 23. annual meeting and 3. German meeting on food irradiation. Book of abstracts

International Nuclear Information System (INIS)

1993-01-01

The book comprises 181 abstracts of the 23rd Annual Meeting of the European Society for New Methods in Agricultural Research and the 3rd German Meeting on Food Irradiation. The following subjects were discussed in six workshops: Radiation Technology and 3rd German Meeting on Food Irradiation (44); Advanced Methods in Animal Sciences (17); Soil-Plant Relationships (36); Plant Genetics, Breeding and Physiology (48); Environmental Aspects and Energy Use (16); Pest Management (20). The abstracts are supplemented by an alphabetic index of authors. (UHE) [de

78 FR 18680 - Genomic Medicine Program Advisory Committee, Notice of Meeting

Science.gov (United States)

2013-03-27

... provide advice and make recommendations to the Secretary of Veterans Affairs on using genetic information... applying appropriate ethical oversight and protecting the privacy of Veterans. The meeting focus will be on... implications of combining information from genetic data with data from publically available genealogy databases...

A Cryogenic Detector Characterization Facility in the Shallow Underground Laboratory at the Technical University of Munich

Science.gov (United States)

Langenkämper, A.; Defay, X.; Ferreiro Iachellini, N.; Kinast, A.; Lanfranchi, J.-C.; Lindner, E.; Mancuso, M.; Mondragón, E.; Münster, A.; Ortmann, T.; Potzel, W.; Schönert, S.; Strauss, R.; Ulrich, A.; Wawoczny, S.; Willers, M.

2018-04-01

The Physics Department of the Technical University of Munich operates a shallow underground detector laboratory in Garching, Germany. It provides ˜ 160 {m^2} of laboratory space which is shielded from cosmic radiation by ˜ 6 m of gravel and soil, corresponding to a shielding of ˜ 15 {m.w.e.} . The laboratory also houses a cleanroom equipped with work- and wetbenches, a chemical fumehood as well as a spin-coater and a mask-aligner for photolithographic processing of semiconductor detectors. Furthermore, the shallow underground laboratory runs two high-purity germanium detector screening stations, a liquid argon cryostat and a ^3 He-^4 He dilution refrigerator with a base temperature of ≤ 12-14 mK . The infrastructure provided by the shallow laboratory is particularly relevant for the characterization of CaWO_4 target crystals for the CRESST-III experiment, detector fabrication and assembly for rare event searches. Future applications of the laboratory include detector development in the framework of coherent neutrino nucleus scattering experiments (ν -cleus) and studying its potential as a site to search for MeV-scale dark matter with gram-scale cryogenic detectors.

WHEAT CHARACTERISTIC DEMAND AND IMPLICATIONS FOR DEVELOPMENT OF GENETICALLY MODIFIED GRAINS

OpenAIRE

Janzen, Edward L.; Mattson, Jeremy W.; Wilson, William W.

2001-01-01

Agricultural biotechnology is advancing rapidly and is embracing all major crops. The adoption of genetically modified corn, soybeans, and cotton have reached high levels in the United States. Wheat is the next major crop confronting the biotechnology issue, but no commercial varieties of genetically modified (GM) wheat have been released yet. Primary opportunities for GM developments in wheat center around improvements that meet consumer and end-user needs/issues in addition to meeting produ...

75 FR 66089 - FIFRA Scientific Advisory Panel; Notice of Public Meeting

Science.gov (United States)

2010-10-27

.... Describe any assumptions and provide any technical information and/or data that you used. 5. If you.... Seating at the meeting. Seating at the meeting will be open and on a first-come basis. 4. Request for... more of the following areas: Corn pest entomology (biology and ecology), population genetics, insect...

Regional monitoring of metals in the Munich metropolitan area: Comparison of biomonitoring (standardized grass culture) with deposition and airborne particles

International Nuclear Information System (INIS)

Dietl, C.; Reifenhaeuser, W.; Vierle, O.; Peichl, L.; Faus-Kessler, Th.

2000-01-01

In the Munich metropolitan area a close association of lead (Pb) and antimony (Sb) impacts with traffic was observed in 1992 and 1993. The intercorrelation of both metals was found by samples of standardised grass cultures and was reflected by deposition sampling, too. With respect to location-specific variations, however, both methods revealed differing gradients of Pb and Sb concentrations with increasing distance from traffic. It appeared that Sb variations according to traffic implications were particularly well indicated by means of biomonitoring, while Pb variations were not indicated adequately. As a result, a special qualification of grass to selectively collect metals on airborne dust according to particle sizes was suggested. Further investigations on the correlations between metal biomonitoring, metal deposition and airborne metals in 1994 - 1996 corroborated method-specific sampling features. They in turn showed that one interference is the individual prevalence of the metals on different particle sizes. (author)

Proton therapy with spot scanning: the Rinecker Proton Therapy Center in Munich. Part 2: Technical and physical aspects

International Nuclear Information System (INIS)

Borchert, H. J.; Mayr, M.; Schneider, R. A.; Arnold, M. R.; Geismar, D. E.; Wilms, M.; Wisser, L.; Herbst, M.

2008-01-01

The Rinecker Proton Therapy Center (RPTC) in Munich is about to introduce into clinical radiation therapy, a 2D scanning technique (spot scanning) of a single proton pencil beam. It will be available at four gantries and a fifth treatment room allocates a fixed beam unit for a scattering technique. A superconducting cyclotron extracts protons with a constant energy of 250 MeV. Far upstream of the patient follows modulation of the energy with a degrader according to the prescription of the patients treatment planning. A 10 mm pencil beam at full width of half maximum (FWHM) will enable scanning of individual tumour volumes at any depth i.e. 1 minute for a target volume of 1 litre and a dose of 2 Gy. Innovative solutions will be established for other important issues such as dosimetric monitoring, safety concepts and positioning of the patient. The physical characteristics of proton beam spot scanning offer exceptional possibilities in conformal radiation therapy. Together with intensity modulated proton therapy (IMPT) it significantly improves the sparing of organs at risk and of healthy tissues. (author)

Joint USDA/DOE meeting

Energy Technology Data Exchange (ETDEWEB)

1994-07-01

This documents contains the details from the USDA/USDOE meeting on April 11--12, 1994. Topics discussed include: genetic research, environmental research, renewable energy sources, food supply, improved fertilizers, new pesticides, research programs combining the efforts of the two agencies to develop new products for use in the agriculture industry, environmentally safe products, getting more with less money, and various other subjects dealing with how cooperation among these agencies can improve the agriculture industry.

Genetics Home Reference: isolated ectopia lentis

Science.gov (United States)

... a common feature of genetic syndromes such as Marfan syndrome and Weill-Marchesani syndrome . Enlarge Frequency The prevalence ... 146 adults not meeting clinical diagnostic criteria for Marfan syndrome: further delineation of type 1 fibrillinopathies and focus ...

Comparing the Morningness-Eveningness Questionnaire and Munich ChronoType Questionnaire to the Dim Light Melatonin Onset.

Science.gov (United States)

Kantermann, Thomas; Sung, Haein; Burgess, Helen J

2015-10-01

The dim light melatonin onset (DLMO) is the most reliable measure of central circadian timing in humans. However, it is not always possible to measure the DLMO because sample collection has to occur in the hours before usual sleep onset, it requires staff support and considerable participant effort, and it is relatively expensive. Questionnaires that ask people about the timing of their behavior, such as their sleep, may provide an easier and less expensive estimate of circadian timing. The objective of this analysis was to compare the MEQ score derived from the Morningness-Eveningness Questionnaire (MEQ) and the MSFsc derived from the Munich ChronoType Questionnaire (MCTQ) to the DLMO in the largest sample to date (N = 60). Our hypothesis was that MSFsc would correlate more highly with the DLMO than MEQ score. Our sample of 36 healthy controls and 24 patients with delayed sleep phase disorder ranged in age from 18 to 62 years. All participants slept at times of their own choosing for a week before the assessment of their DLMO. The DLMO correlated significantly with both the MEQ score (r = -0.70, p light or exogenous melatonin treatment, as this could result in the mistiming of these treatments relative to the DLMO, thereby potentially worsening circadian misalignment. © 2015 The Author(s).

Risk markers for development of small and large nerve fiber lesion in patients with diabetes

Czech Academy of Sciences Publication Activity Database

Malá, S.; Potočková, V.; Hoskovcová, L.; Brabec, Marek; Brož, J.; Kvapil, M.

2016-01-01

Roč. 59, 1 Suppl (2016), S462-S462 ISSN 0012-186X. [EASD Annual Meeting /52./. 12.09.2016-16.09.2016, Munich] Institutional support: RVO:67985807 Keywords : diabetes * markers Subject RIV: FB - Endocrinology, Diabetology, Metabolism, Nutrition

Report of the Advisory Group Meeting on Genetic Methods of Insect Control

International Nuclear Information System (INIS)

1987-01-01

Despite the availability of a range of modern pest control techniques, insects remain a major cause of production losses in agriculture and contribute significantly to diseases of man and livestock. The increasing incidence of pesticide resistance, and concerns over the environmental impact of residues, have highlighted the need for improved technologies. As a result, genetic methods of pest control, including the use of irradiation sterilized insects, have become of increasing importance. It is therefore essential that the Joint FAO/IAEA Division continues to promote the development and application of this method of pest control. The advisory group concluded that the opportunities for genetic control might be widened by the application of new techniques, particularly recombinant DNA technology. The scope for integration of genetic control methods with other control measures, and ist use as a temporary suppressive measure on an area-wide basis was also recognized. Examples are given from representative groups of insect pests to illustrate how these concepts can be applied. The advisory group regarded the Seibersdorf laboratory as a unique facility for the conduct of tactical research related to mass-rearing and release procedures for major pests such as medfly and tsetse spp. Associated research on genetic sexing of medfly, diet recycling and the development of more environmentally acceptable alternatives for pre-release suppression of medfly were considered to be important research projects. The advisory group concluded that the laboratory should continue to remain a centre of excellence for mass-rearing technologies for medfly and tsetse spp., and for training scientists and technicians from developing countries. The Joint FAO/IAEA Division currently plays a major co-ordinating and supportive role for those areas of international research which impinge on genetic control. The advisory group believes that the Joint FAO/IAEA Division should maintain its initiative

Report of the Advisory Group Meeting on Genetic Methods of Insect Control

Energy Technology Data Exchange (ETDEWEB)

NONE

1987-07-01

Despite the availability of a range of modern pest control techniques, insects remain a major cause of production losses in agriculture and contribute significantly to diseases of man and livestock. The increasing incidence of pesticide resistance, and concerns over the environmental impact of residues, have highlighted the need for improved technologies. As a result, genetic methods of pest control, including the use of irradiation sterilized insects, have become of increasing importance. It is therefore essential that the Joint FAO/IAEA Division continues to promote the development and application of this method of pest control. The advisory group concluded that the opportunities for genetic control might be widened by the application of new techniques, particularly recombinant DNA technology. The scope for integration of genetic control methods with other control measures, and ist use as a temporary suppressive measure on an area-wide basis was also recognized. Examples are given from representative groups of insect pests to illustrate how these concepts can be applied. The advisory group regarded the Seibersdorf laboratory as a unique facility for the conduct of tactical research related to mass-rearing and release procedures for major pests such as medfly and tsetse spp. Associated research on genetic sexing of medfly, diet recycling and the development of more environmentally acceptable alternatives for pre-release suppression of medfly were considered to be important research projects. The advisory group concluded that the laboratory should continue to remain a centre of excellence for mass-rearing technologies for medfly and tsetse spp., and for training scientists and technicians from developing countries. The Joint FAO/IAEA Division currently plays a major co-ordinating and supportive role for those areas of international research which impinge on genetic control. The advisory group believes that the Joint FAO/IAEA Division should maintain its initiative

Investigation of the transition from forced to natural convection in the research reactor Munich II

International Nuclear Information System (INIS)

Skreba, S.; Adamek, J.; Unger, H.

1999-01-01

The new research reactor Munich II (FRM-II), which is under construction at the Technical University Munich, Germany, makes use of a newly developed compact reactor core consisting of a single fuel element, which is assembled of two concentric pipes. Between the fuel element's inner and outer pipe 113 involutely bent fuel plates are placed rotationally symmetric, forming 113 cooling channels of a constant width of 2.2 mm. After a shut down of the reactor, battery supported cooling pumps are started by the reactor safety system in order to remove the decay heat by a downwards directed forced flow. Three hours after they have been started, the cooling pumps are shut down and so-called 'natural convection flaps' are opened by their own weight. Through a flow path, which is provided by the opening of the natural convection flaps, the decay heat is given off to the water in the reactor pool after the direction of the flow has changed and an upwards directed natural convection flow has developed. At the Department for Nuclear and New Energy Systems of the Ruhr-University Bochum, Germany, a test facility has been built in order to confirm the concept of the decay heat removal in the FRM-II, to acquire data of single and two phase natural convection flows and to detect the dry out in a narrow channel. The thermohydraulics of the FRM-II are simulated by an electrically heated test section, which represents one cooling channel of the fuel element. At first experiments have been performed, which simulated the transition from forced to natural convection in the core of the FRM-II, both at normal operation and at a complete loss of the decay heat removal pumps. In case of normal operation, the transition from forced to natural convection takes place single phased. If a complete loss of the active decay heat removal system occurs, the decay heat removal is ensured by a quasi-steady two phase flow. In a second test series minimum heat flux densities leading to pressure pulsations

Optimization of a partially non-magnetic primary radiation shielding for the triple-axis spectrometer PANDA at the Munich high-flux reactor FRM-II

CERN Document Server

Pyka, N M; Rogov, A

2002-01-01

Monte Carlo simulations have been used to optimize the monochromator shielding of the polarized cold-neutron triple-axis spectrometer PANDA at the Munich high-flux reactor FRM-II. By using the Monte Carlo program MCNP-4B, the density of the total spectrum of incoming neutrons and gamma radiation from the beam tube SR-2 has been determined during the three-dimensional diffusion process in different types of heavy concrete and other absorbing material. Special attention has been paid to build a compact and highly efficient shielding, partially non-magnetic, with a total biological radiation dose of less than 10 mu Sv/h at its outsides. Especially considered was the construction of an albedo reducer, which serves to reduce the background in the experiment outside the shielding. (orig.)

Introduction to Genetic Mechanisms of Carcinogenesis

International Nuclear Information System (INIS)

Yang, W.K.

1983-01-01

Recent technical advances in nucleic acid research and molecular biology have made it possible to explore the complicated genetic systems of eukaryotic cells. One of the fields showing rapid progress concerns genes and gene regulatory functions related to neoplastic processes. Thus, the 35th Annual Conference of the Biology Division of Oak Ridge National Laboratory, held at Gatlinburg, April 12-15, 1982, was organized with the intention to bring together investigators working on seemingly diverse fields of cancer research to discuss and exchange their views on the genetic mechanisms of carcinogenesis. The meeting was attended by workers from chemical, physical as well as biological carcinogenesis fields, by classical geneticists as well as by molecular biologists, and by researchers interested in experimental as well as in human cancers. Included in this volume are papers by the invited speakers of the symposium as well as by those presenting poster papers at the meeting

Use of novel DNA fingerprinting techniques for the detection and characterization of genetic variation in vegetatively propagated crops. Proceedings of a final research co-ordination meeting

International Nuclear Information System (INIS)

1998-10-01

Vegetative propagated crops, such as banana and platain, sweet potato, yam, sugarcane and cassava, represent important sources of food in the developing countries. Although some of these crops may produce seeds, they must for practical purposes be propagated vegetatively. As normal plant breeding strategies based on genetic hybridization are of limited value or not applicable to such crops, it is necessary to assess the genetic diversity already existing in these crops and to design breeding strategies accordingly. If the existing genetic variation is shown to be too narrow for breeding purposes, one promising possibility for the introduction of genetic variability is the use of mutations induced by radiation or chemical mutagens. This CRP focused on: the detection of genetic diversity induced by mutagenic treatment or in vitro culture; the development of crop-specific markers; and increasing co-operation between molecular biologists in advanced laboratories and plant breeders and molecular biologists in the developing countries. The success of this CRP is evidenced by the introduction and application of new molecular methods by laboratories in developing countries, specially for the analysis of local crop genetic diversity. These exciting preliminary results show the potential for applications in crop improvement but much work remains to be done. Many of the vegetatively propagated species are ''orphan crops'', under-investigated on the international level. The development of new uses of transgenesis for the development of edible vaccines should not be overlooked. The challenge that remains is in the application of these new tools for practical end-user oriented improvements in vegetatively propagated crops. The present publication summarizes the third and final Research Co-ordination Meeting on the Use of Novel DNA Fingerprinting Techniques for the Detection and Characterization of Genetic Variation in Vegetatively Propagated Crops

Use of novel DNA fingerprinting techniques for the detection and characterization of genetic variation in vegetatively propagated crops. Proceedings of a final research co-ordination meeting

Energy Technology Data Exchange (ETDEWEB)

NONE

1998-10-01

Vegetative propagated crops, such as banana and platain, sweet potato, yam, sugarcane and cassava, represent important sources of food in the developing countries. Although some of these crops may produce seeds, they must for practical purposes be propagated vegetatively. As normal plant breeding strategies based on genetic hybridization are of limited value or not applicable to such crops, it is necessary to assess the genetic diversity already existing in these crops and to design breeding strategies accordingly. If the existing genetic variation is shown to be too narrow for breeding purposes, one promising possibility for the introduction of genetic variability is the use of mutations induced by radiation or chemical mutagens. This CRP focused on: the detection of genetic diversity induced by mutagenic treatment or in vitro culture; the development of crop-specific markers; and increasing co-operation between molecular biologists in advanced laboratories and plant breeders and molecular biologists in the developing countries. The success of this CRP is evidenced by the introduction and application of new molecular methods by laboratories in developing countries, specially for the analysis of local crop genetic diversity. These exciting preliminary results show the potential for applications in crop improvement but much work remains to be done. Many of the vegetatively propagated species are ``orphan crops``, under-investigated on the international level. The development of new uses of transgenesis for the development of edible vaccines should not be overlooked. The challenge that remains is in the application of these new tools for practical end-user oriented improvements in vegetatively propagated crops. The present publication summarizes the third and final Research Co-ordination Meeting on the Use of Novel DNA Fingerprinting Techniques for the Detection and Characterization of Genetic Variation in Vegetatively Propagated Crops Refs, figs, tabs

Multi-scale modeling of urban air pollution: development and application of a Street-in-Grid model (v1.0) by coupling MUNICH (v1.0) and Polair3D (v1.8.1)

OpenAIRE

Y. Kim; Y. Wu; C. Seigneur; Y. Roustan

2018-01-01

A new multi-scale model of urban air pollution is presented. This model combines a chemistry–transport model (CTM) that includes a comprehensive treatment of atmospheric chemistry and transport on spatial scales down to 1 km and a street-network model that describes the atmospheric concentrations of pollutants in an urban street network. The street-network model is the Model of Urban Network of Intersecting Canyons and Highways (MUNICH), which consists of two main components...

Daily and seasonal variation of short-lived radon decay product concentrations in ground-level air at Munich-Neuherberg - a long-term study

International Nuclear Information System (INIS)

Winkler, R.

2001-09-01

Daily and seasonal variation of the equilibrium equivalent radon concentration (EEC Rn-222 ) and of the concentration of the short-lived radon decay product 214 Pb in ground-level air was investigated at Munich-Neuherberg from 1982 to 2000, and from 1989 to 2000, respectively. For this, the EEC was measured continuously with an alpha/beta aerosol monitor at 2.5 m above ground, and 214 Pb was determined by online gamma spectrometry at about 12 m above ground. The resulting time series were analysed statistically. For the respective periods, the measurements yielded a long-term average concentration of 7.8 Bq m -3 (geometric mean: 6.1 Bq m -3 ) for the EEC, and 6.0 Bq m -3 (geom. mean: 5.0 Bq m -3 ) for 214 Pb. In these periods, daily averages ranged from 0.6 to 49 Bq m -3 (EEC), and from 0.6 to 43 Bq m -3 ( 214 Pb). Monthly mean concentrations varied between 3.0 Bq m -3 in March 1988 and 20 Bq m -3 in October 1985 (EEC), and from 3.4 Bq m -3 in April 1992 to 11 Bq m -3 in October 1995 ( 214 Pb), respectively. The annual average concentrations were from 5.9 Bq m -3 in 1999 to 10.6 Bq m -3 in 1985 (EEC), and from 5.3 Bq m -3 in 1999 to 6.8 Bq m -3 in 1991 ( 214 Pb). From the long-term average equilibrium equivalent radon concentration (EEC), an average annual effective dose of 0.13 mSv due to the short-lived radon progeny outdoors was estimated. The time series showed distinct daily and seasonal variations. The variations from day to day are mainly caused by the actual weather conditions (wind, rain, etc.), i.e. the short-term turbulent conditions. The seasonal pattern is characterised by an autumn to winter maximum and an early summer minimum, and reflects the prevailing turbulent conditions at the respective seasons. As known, at Munich-Neuherberg during autumn and winter months (October/November to February) inversion weather conditions frequently occur, while the other months are characterised by more turbulent conditions. (orig.)

IGORR 1: Proceedings of the 1. meeting of the International Group On Research Reactors

Energy Technology Data Exchange (ETDEWEB)

West, C D [comp.

1990-05-01

Descriptions of the ongoing projects presented at this Meeting were concerned with: New Research Reactor FRM-II at Munich; MITR-II reactor; The Advanced. Neutron Source (ANS) Project; The high Flux Reactor Petten, Status and Prospects; The High Flux Beam Reactor Instrumentation Upgrade; BER-II Upgrade; The BR2 Materials Testing Reactor Past, Ongoing and Under-Study Upgrades; The ORPHEE, Reactor Current Status and Proposed Enhancement of Experimental Variabilities; Construction of the Upgraded JRR-3; Status of the University of Missouri-Columbia Research Reactor Upgrade; the Reactor and Cold Neutron Facility at NIST; Upgrade of Materials Irradiation Facilities in HFIR; Backfitting of the FRG Reactors; University Research Reactors in the United States; and Organization of the ITER Project - Sharing of Informational Procurements. Topics of interest were: Thermal-hydraulic tests and correlations, Corrosion tests and analytical models , Multidimensional kinetic analysis for small cores, Fuel plates fabrication, Fuel plates stability, Fuel irradiation, Burnable poison irradiation, Structural materials irradiation, Neutron guides irradiation, Cold Source materials irradiation, Cold Source LN{sub 2} test, Source LH2-H{sub 2}O reaction (H or D), Instrumentation upgrading and digital control system, Man-machine interface.

IGORR 1: Proceedings of the 1. meeting of the International Group On Research Reactors

International Nuclear Information System (INIS)

West, C.D.

1990-05-01

Descriptions of the ongoing projects presented at this Meeting were concerned with: New Research Reactor FRM-II at Munich; MITR-II reactor; The Advanced. Neutron Source (ANS) Project; The high Flux Reactor Petten, Status and Prospects; The High Flux Beam Reactor Instrumentation Upgrade; BER-II Upgrade; The BR2 Materials Testing Reactor Past, Ongoing and Under-Study Upgrades; The ORPHEE, Reactor Current Status and Proposed Enhancement of Experimental Variabilities; Construction of the Upgraded JRR-3; Status of the University of Missouri-Columbia Research Reactor Upgrade; the Reactor and Cold Neutron Facility at NIST; Upgrade of Materials Irradiation Facilities in HFIR; Backfitting of the FRG Reactors; University Research Reactors in the United States; and Organization of the ITER Project - Sharing of Informational Procurements. Topics of interest were: Thermal-hydraulic tests and correlations, Corrosion tests and analytical models , Multidimensional kinetic analysis for small cores, Fuel plates fabrication, Fuel plates stability, Fuel irradiation, Burnable poison irradiation, Structural materials irradiation, Neutron guides irradiation, Cold Source materials irradiation, Cold Source LN 2 test, Source LH2-H 2 O reaction (H or D), Instrumentation upgrading and digital control system, Man-machine interface

77 FR 16898 - Genomic Medicine Program Advisory Committee, Notice of Meeting

Science.gov (United States)

2012-03-22

... protecting the privacy of Veterans. The meeting focus will be on policies, regulations, and implications for... Secretary of Veterans Affairs on using genetic information to optimize medical care of Veterans, and to...

76 FR 65563 - Genomic Medicine Program Advisory Committee; Notice of Meeting

Science.gov (United States)

2011-10-21

... oversight and protecting the privacy of Veterans. The meeting focus will be on current and upcoming... recommendations to the Secretary of Veterans Affairs on using genetic information to optimize medical care of...

Tumor Markers as a Possible Tool for Differential Diagnosis in Lung Diseases

Czech Academy of Sciences Publication Activity Database

Pikner, R.; Čertíková, G.; Topolčan, O.; Pešek, M.; Holubec, L.; Pecen, Ladislav; Spilková, I.; Paříková, I.

2000-01-01

Roč. 21, Suppl.1 (2000), s. 123 ISSN 1010-4283. [Meeting of the International Society for Oncodevelopmental Biology and Medicine /28./. 08.09.2000-13.09.2000, Munich] Grant - others:IGA MZ ČR(CZ) NC4780 Institutional research plan: AV0Z1030915

Connexion between Diabetes Mellitus and the Incidence of Tumor Diseases

Czech Academy of Sciences Publication Activity Database

Steinerová, A.; Topolčan, O.; Vlasák, J.; Holubec, L.; Svačina, Š.; Pecen, Ladislav; Matoulek, M.; Svobodová, S.; Pikner, R.

2000-01-01

Roč. 21, Suppl.1 (2000), s. 113 ISSN 1010-4283. [Meeting of the International Society for Oncodevelopmental Biology and Medicine /28./. 08.09.2000-13.09.2000, Munich] Grant - others:IGA MZ ČR(CZ) NC4780 Institutional research plan: AV0Z1030915

Genetic Variation in Choline-Metabolizing Enzymes Alters Choline Metabolism in Young Women Consuming Choline Intakes Meeting Current Recommendations

Directory of Open Access Journals (Sweden)

Ariel B. Ganz

2017-01-01

Full Text Available Single nucleotide polymorphisms (SNPs in choline metabolizing genes are associated with disease risk and greater susceptibility to organ dysfunction under conditions of dietary choline restriction. However, the underlying metabolic signatures of these variants are not well characterized and it is unknown whether genotypic differences persist at recommended choline intakes. Thus, we sought to determine if common genetic risk factors alter choline dynamics in pregnant, lactating, and non-pregnant women consuming choline intakes meeting and exceeding current recommendations. Women (n = 75 consumed 480 or 930 mg choline/day (22% as a metabolic tracer, choline-d9 for 10–12 weeks in a controlled feeding study. Genotyping was performed for eight variant SNPs and genetic differences in metabolic flux and partitioning of plasma choline metabolites were evaluated using stable isotope methodology. CHKA rs10791957, CHDH rs9001, CHDH rs12676, PEMT rs4646343, PEMT rs7946, FMO3 rs2266782, SLC44A1 rs7873937, and SLC44A1 rs3199966 altered the use of choline as a methyl donor; CHDH rs9001 and BHMT rs3733890 altered the partitioning of dietary choline between betaine and phosphatidylcholine synthesis via the cytidine diphosphate (CDP-choline pathway; and CHKA rs10791957, CHDH rs12676, PEMT rs4646343, PEMT rs7946 and SLC44A1 rs7873937 altered the distribution of dietary choline between the CDP-choline and phosphatidylethanolamine N-methyltransferase (PEMT denovo pathway. Such metabolic differences may contribute to disease pathogenesis and prognosis over the long-term.

76 FR 24573 - Genomic Medicine Program Advisory Committee; Notice of Meeting

Science.gov (United States)

2011-05-02

... appropriate ethical oversight and protecting the privacy of Veterans. The meeting focus will be on current and... recommendations to the Secretary of Veterans Affairs on using genetic information to optimize medical care of...

Genetic Simulation Tools for Post-Genome Wide Association Studies of Complex Diseases

Science.gov (United States)

Amos, Christopher I.; Bafna, Vineet; Hauser, Elizabeth R.; Hernandez, Ryan D.; Li, Chun; Liberles, David A.; McAllister, Kimberly; Moore, Jason H.; Paltoo, Dina N.; Papanicolaou, George J.; Peng, Bo; Ritchie, Marylyn D.; Rosenfeld, Gabriel; Witte, John S.

2014-01-01

Genetic simulation programs are used to model data under specified assumptions to facilitate the understanding and study of complex genetic systems. Standardized data sets generated using genetic simulation are essential for the development and application of novel analytical tools in genetic epidemiology studies. With continuing advances in high-throughput genomic technologies and generation and analysis of larger, more complex data sets, there is a need for updating current approaches in genetic simulation modeling. To provide a forum to address current and emerging challenges in this area, the National Cancer Institute (NCI) sponsored a workshop, entitled “Genetic Simulation Tools for Post-Genome Wide Association Studies of Complex Diseases” at the National Institutes of Health (NIH) in Bethesda, Maryland on March 11-12, 2014. The goals of the workshop were to: (i) identify opportunities, challenges and resource needs for the development and application of genetic simulation models; (ii) improve the integration of tools for modeling and analysis of simulated data; and (iii) foster collaborations to facilitate development and applications of genetic simulation. During the course of the meeting the group identified challenges and opportunities for the science of simulation, software and methods development, and collaboration. This paper summarizes key discussions at the meeting, and highlights important challenges and opportunities to advance the field of genetic simulation. PMID:25371374

Gordon Research Conference on Genetic Toxicology

Energy Technology Data Exchange (ETDEWEB)

Project Director Penelope Jeggo

2003-02-15

Genetic toxicology represents a study of the genetic damage that a cell can incur, the agents that induce such damage, the damage response mechanisms available to cells and organisms, and the potential consequences of such damage. Genotoxic agents are abundant in the environment and are also induced endogenously. The consequences of such damage can include carcinogenesis and teratogenesis. An understanding of genetic toxicology is essential to carry out risk evaluations of the impact of genotoxic agents and to assess how individual genetic differences influence the response to genotoxic damage. In recent years, the importance of maintaining genomic stability has become increasingly recognized, in part by the realization that failure of the damage response mechanisms underlies many, if not all, cancer incidence. The importance of these mechanisms is also underscored by their remarkable conservation between species, allowing the study of simple organisms to provide significant input into our understanding of the underlying mechanisms. It has also become clear that the damage response mechanisms interface closely with other aspects of cellular metabolism including replication, transcription and cell cycle regulation. Moreover, defects in many of these mechanisms, as observed for example in ataxia telangiectasia patients, confer disorders with associated developmental abnormalities demonstrating their essential roles during growth and development. In short, while a decade ago, a study of the impact of DNA damage was seen as a compartmentalized area of cellular research, it is now appreciated to lie at the centre of an array of cellular responses of crucial importance to human health. Consequently, this has become a dynamic and rapidly advancing area of research. The Genetic Toxicology Gordon Research Conference is biannual with an evolving change in the emphasis of the meetings. From evaluating the nature of genotoxic chemicals, which lay at the centre of the early

When Markers Meet Marketing: Ethnicity, Race, Hybridity, and Kinship in Genetic Genealogy Television Advertising

Directory of Open Access Journals (Sweden)

Christine Scodari

2017-12-01

Full Text Available The essay explores issues pertaining to genetics vs. culture in understandings of kinship, hybridity as a disruptor of essentialist conceptions of race, the fetishization of ethnicity and culture, racist misuses of genetic science, processes of racialization, and counter-hegemonic resistance. Thirty- and sixty-second television advertisements airing in the U.S. from the 23andMe and AncestryDNA genetic genealogy testing services are analyzed in this context. The investigation demonstrates that genetic ancestry testing providers are well aware that their enterprise is premised on belief in the superiority of biological kinship and that hybridity is mobilized primarily as a marketing opportunity with ethnic components signified in shorthand by fetishized objects. Moreover, the categories of race and ethnicity presented in the ads give cover to racist abusers of genetic science, as the ads are consistent with socially constructed racial classifications. While maintaining this consistency, the categories are subject to adjustment based on the expectations of consumers. Resistance is possible in the use of genetic ancestry by descendants of African slaves to make localized connections to Africa, something that conventional genealogy seldom provides.

Plant breeding and genetics newsletter. No. 14

International Nuclear Information System (INIS)

2004-12-01

These last six months, the Plant Breeding and Genetics (PBG) Section of the Joint FAO/IAEA Division (NAFA/AGE) implemented five Research Coordination Meetings (RCMs) and one Consultants Meeting for a new Coordinated Research Project (CRP) on 'Molecular tools for quality improvement in vegetatively propagated crops including banana and cassava' (8-11 November 2004, Vienna). Other salient points were the training courses we implemented this semester in the framework of different Technical Cooperation (TC) projects.Details about these activities inside this Newsletter

Highlights from the 7th European Meeting on Molecular Diagnostics

NARCIS (Netherlands)

Dr. A.J.C. van den Brule, van den; Drs A.J.M. Loonen; Dr. R. Schuurman

2012-01-01

This report presents the highlights of the 7th European Meeting on Molecular Diagnostics held in Scheveningen, The Hague, The Netherlands, 12-14 October 2011. The areas covered included molecular diagnostics applications in medical microbiology, virology, pathology, hemato-oncology,clinical genetics

Meeting review. Uncovering the genetic basis of adaptive change: on the intersection of landscape genomics and theoretical population genetics.

Science.gov (United States)

Joost, Stéphane; Vuilleumier, Séverine; Jensen, Jeffrey D; Schoville, Sean; Leempoel, Kevin; Stucki, Sylvie; Widmer, Ivo; Melodelima, Christelle; Rolland, Jonathan; Manel, Stéphanie

2013-07-01

A workshop recently held at the École Polytechnique Fédérale de Lausanne (EPFL, Switzerland) was dedicated to understanding the genetic basis of adaptive change, taking stock of the different approaches developed in theoretical population genetics and landscape genomics and bringing together knowledge accumulated in both research fields. Indeed, an important challenge in theoretical population genetics is to incorporate effects of demographic history and population structure. But important design problems (e.g. focus on populations as units, focus on hard selective sweeps, no hypothesis-based framework in the design of the statistical tests) reduce their capability of detecting adaptive genetic variation. In parallel, landscape genomics offers a solution to several of these problems and provides a number of advantages (e.g. fast computation, landscape heterogeneity integration). But the approach makes several implicit assumptions that should be carefully considered (e.g. selection has had enough time to create a functional relationship between the allele distribution and the environmental variable, or this functional relationship is assumed to be constant). To address the respective strengths and weaknesses mentioned above, the workshop brought together a panel of experts from both disciplines to present their work and discuss the relevance of combining these approaches, possibly resulting in a joint software solution in the future.

Genetically modified foods and allergy.

Science.gov (United States)

Lee, T H; Ho, H K; Leung, T F

2017-06-01

2015 marked the 25th anniversary of the commercial use and availability of genetically modified crops. The area of planted biotech crops cultivated globally occupies a cumulative two billion hectares, equivalent to twice the land size of China or the United States. Foods derived from genetically modified plants are widely consumed in many countries and genetically modified soybean protein is extensively used in processed foods throughout the industrialised countries. Genetically modified food technology offers a possible solution to meet current and future challenges in food and medicine. Yet there is a strong undercurrent of anxiety that genetically modified foods are unsafe for human consumption, sometimes fuelled by criticisms based on little or no firm evidence. This has resulted in some countries turning away food destined for famine relief because of the perceived health risks of genetically modified foods. The major concerns include their possible allergenicity and toxicity despite the vigorous testing of genetically modified foods prior to marketing approval. It is imperative that scientists engage the public in a constructive evidence-based dialogue to address these concerns. At the same time, improved validated ways to test the safety of new foods should be developed. A post-launch strategy should be established routinely to allay concerns. Mandatory labelling of genetically modified ingredients should be adopted for the sake of transparency. Such ingredient listing and information facilitate tracing and recall if required.

Energy efficiency. A constant challenge to science and practice. Proceedings. 2. ed.; Energieeffizienz. Eine stete Herausforderung an Wissenschaft und Praxis. Tagungsband

Energy Technology Data Exchange (ETDEWEB)

Wagner, Ulrich (ed.)

2011-07-01

Within the meeting ''Energy efficiency'' of the Research Center for Energy Economics (Munich, Federal Republic of Germany) from 12th to 13th May, 2011, at the Munich Residenz (Munich, Federal Republic of Germany) the following lectures were presented: (1) Innovation and research for an enhanced energy efficiency - New accents in the energy research politics of the Federal Government (Knut Kuebler); (2) Revolution of efficiency in the monastery St. Ottilien (Wolfgang Mauch); (3) From the maser plan to the local plan of energy utilization (Tobias Schmid); (4) The life cycle approach as a driver for innovative energy contracting (Alfred Gayer); (5) Energy efficiency networks (Anna Gruber); (6) Grid expansion for an enhanced utilization of renewable energies (Martin Fuchs); (7) Storage requirement in the electrical grid; (8) Scenarios for the development of the electromobility in Munich (Stephan Brunnert); (9) Li ion batteries for electrified automobiles - Demands and status (Peter Lamp); (10) Marketing of wind power (Serafin von Roon); (11) Demand side management in non-residential buildings (Johannes Jungwirth); (12) Energy future 2050 (Ulrich Wagner); (13) Decentral and renewable power generation (Ulli Arndt); (14) Electromobility - is that the future? (Markus Lienkamp); (14) Electric power - Reason or solution of the climate problem? (Harald Lesch).

Energy efficiency. A constant challenge to science and practice. Proceedings. 2. ed.; Energieeffizienz. Eine stete Herausforderung an Wissenschaft und Praxis. Tagungsband

Energy Technology Data Exchange (ETDEWEB)

Wagner, Ulrich [ed.

2011-07-01

Within the meeting ''Energy efficiency'' of the Research Center for Energy Economics (Munich, Federal Republic of Germany) from 12th to 13th May, 2011, at the Munich Residenz (Munich, Federal Republic of Germany) the following lectures were presented: (1) Innovation and research for an enhanced energy efficiency - New accents in the energy research politics of the Federal Government (Knut Kuebler); (2) Revolution of efficiency in the monastery St. Ottilien (Wolfgang Mauch); (3) From the maser plan to the local plan of energy utilization (Tobias Schmid); (4) The life cycle approach as a driver for innovative energy contracting (Alfred Gayer); (5) Energy efficiency networks (Anna Gruber); (6) Grid expansion for an enhanced utilization of renewable energies (Martin Fuchs); (7) Storage requirement in the electrical grid; (8) Scenarios for the development of the electromobility in Munich (Stephan Brunnert); (9) Li ion batteries for electrified automobiles - Demands and status (Peter Lamp); (10) Marketing of wind power (Serafin von Roon); (11) Demand side management in non-residential buildings (Johannes Jungwirth); (12) Energy future 2050 (Ulrich Wagner); (13) Decentral and renewable power generation (Ulli Arndt); (14) Electromobility - is that the future? (Markus Lienkamp); (14) Electric power - Reason or solution of the climate problem? (Harald Lesch).

Genetic Variability of Myxoma Virus Genomes

OpenAIRE

Braun, Christoph; Thürmer, Andrea; Daniel, Rolf; Schultz, Anne-Kathrin; Bulla, Ingo; Schirrmeier, Horst; Mayer, Dietmar; Neubert, Andreas; Czerny, Claus-Peter

2017-01-01

Myxomatosis is a recurrent problem on rabbit farms throughout Europe despite the success of vaccines. To identify gene variations of field and vaccine strains that may be responsible for changes in virulence, immunomodulation, and immunoprotection, the genomes of 6 myxoma virus (MYXV) strains were sequenced: German field isolates Munich-1, FLI-H, 2604, and 3207; vaccine strain MAV; and challenge strain ZA. The analyzed genomes ranged from 147.6 kb (strain MAV) to 161.8 kb (strain 3207). All s...

Rendezvous maneuvers using Genetic Algorithm

International Nuclear Information System (INIS)

Dos Santos, Denílson Paulo Souza; De Almeida Prado, Antônio F Bertachini; Teodoro, Anderson Rodrigo Barretto

2013-01-01

The present paper has the goal of studying orbital maneuvers of Rendezvous, that is an orbital transfer where a spacecraft has to change its orbit to meet with another spacecraft that is travelling in another orbit. This transfer will be accomplished by using a multi-impulsive control. A genetic algorithm is used to find the transfers that have minimum fuel consumption

Cancer genetics meets biomolecular mechanism-bridging an age-old gulf.

Science.gov (United States)

González-Sánchez, Juan Carlos; Raimondi, Francesco; Russell, Robert B

2018-02-01

Increasingly available genomic sequencing data are exploited to identify genes and variants contributing to diseases, particularly cancer. Traditionally, methods to find such variants have relied heavily on allele frequency and/or familial history, often neglecting to consider any mechanistic understanding of their functional consequences. Thus, while the set of known cancer-related genes has increased, for many, their mechanistic role in the disease is not completely understood. This issue highlights a wide gap between the disciplines of genetics, which largely aims to correlate genetic events with phenotype, and molecular biology, which ultimately aims at a mechanistic understanding of biological processes. Fortunately, new methods and several systematic studies have proved illuminating for many disease genes and variants by integrating sequencing with mechanistic data, including biomolecular structures and interactions. These have provided new interpretations for known mutations and suggested new disease-relevant variants and genes. Here, we review these approaches and discuss particular examples where these have had a profound impact on the understanding of human cancers. © 2018 Federation of European Biochemical Societies.

Meeting Report: The Twelfth International Mouse Genome Conference

Energy Technology Data Exchange (ETDEWEB)

Manolakou, Katerina; Cross, Sally H.; Simpson, Eleanor H.; Jackson, Ian J.

1998-10-01

The annual International Mouse Genome Conference (IMGC) is where, scientifically speaking, classical mouse genetics meets the relative newcomer of genomics. The 12th meeting took place last October in the delightful Bavarian village of Garmisch-Partenkirchen, and we were greeted by the sight on the mountains of the first snowfall of the season. However the discussions left little time for exploration. Minds of participants in Garmisch were focused by a recent document produced by the NIH and by discussions within other funding agencies worldwide. If implemented, the proposals will further enhance the status of the mouse as the principal model for study of the function of the human genome.

An integrated system for genetic analysis

Directory of Open Access Journals (Sweden)

Duan Xiao

2006-04-01

Full Text Available Abstract Background Large-scale genetic mapping projects require data management systems that can handle complex phenotypes and detect and correct high-throughput genotyping errors, yet are easy to use. Description We have developed an Integrated Genotyping System (IGS to meet this need. IGS securely stores, edits and analyses genotype and phenotype data. It stores information about DNA samples, plates, primers, markers and genotypes generated by a genotyping laboratory. Data are structured so that statistical genetic analysis of both case-control and pedigree data is straightforward. Conclusion IGS can model complex phenotypes and contain genotypes from whole genome association studies. The database makes it possible to integrate genetic analysis with data curation. The IGS web site http://bioinformatics.well.ox.ac.uk/project-igs.shtml contains further information.

Genetic privacy and non-discrimination.

Science.gov (United States)

Romeo Casabona, Carlos María

2011-01-01

The UN Inter-Agency Committee on Bioethics met for its tenth meeting at the UNESCO headquarters in Paris on 4-5th March 2011. Member organisations such as the WHO and UNESCO were in attendance alongside associate members such as the Council for Europe, the European Commission, the Organisation for Economic Co-operation and Development and the World Trade Organisation. Discussion centred on the theme "genetic privacy and nondiscrimination". The United Nations Economic and Social Council (ECOSOC) had previously considered, from a legal and ethical perspective, the implications of increasingly sophisticated technologies for genetic privacy and non-discrimination in fields such as medicine, employment and insurance. Thus, the ECOSOC requested that UNESCO report on relevant developments in the field of genetic privacy and non-discrimination. In parallel with a consultation process with member states, UNESCO launched a consultation with the UN Interagency Committee on Bioethics. This article analyses the report presented by the author concerning the analysis of the current contentions in the field and illustrates attempts at responding on a normative level to a perceived threat to genetic privacy and non-discrimination.

Agrobiodiversity Genetic Variability Utilization in Organic Food Production

Directory of Open Access Journals (Sweden)

Dimitrijević Miodrag

2018-03-01

Full Text Available The food production at the global level is about to meet its border. Industrialization of agriculture correlates with an explosive enlargement of human population, during XX and at the beginning of XXI centuries. An ongoing process of environmental erosion has been speeding up during that period, not only in our physical surrounding, but also in biodiversity. A new direction in agricultural food production is in demand. Organic food production has been recognized as the way of providing safety and quality food, preserving the environment in the same time. In the other hand new land areas have to be explored for agricultural use, in order to enhance food quantity to meeting the increasing demand for food. These targets set new requirements in plant breeding. To fulfill these requirements the genetic variability harbored in genetic resources has to be preserved, examined and put to good use.

Development and construction of a focal-plane detector for the Munich Q3D spectrograph

International Nuclear Information System (INIS)

Lindner, H.

1989-01-01

For the Munich Q3D magnet spectrograph a focal-plane detector was developed, constructed, and taken in operation. It is primary layed out for light ions like p, d, t 3 He, and 4 He, but can be also applied for heavy ions. The position resolution amounts to about 0.1 mm at counting rates of about 10 kHz. In the detector filled with counting gas on anode wires along the focal plane charge avalanches are formed, which influence in several neighbouring cathode stripes of the dimension (3x25) mm 2 signals. These signals are singularily read out and digitized, i.e. to each of the at the whole 114 cathode strips is assigned an own preamplifier, puls shaper, peak detector, and analog-to-digital converter (ADC). After the digitization in a hardware-like constructed calculator unit the center of mass of the charge distribution influenced by the charge avalanche is calculated, the position of the incident particle is obtained. The detector yields beyond the position signal yet also a signal ΔE form the anode wires, which gives the energy loss of the particle in the gas space, as well as a residual-energy signal E rest from a scintillator, in which the particles are stopped. By this the radiation background (γ's and n) can be separated very well from the required particles. With the focal-plane detector the 103 Rh(d, p) 104 Rh transfer reaction was measured at three different spectrograph angles. The measured level energies and angular momentum transfers are compared with (n, γ) data and discussed. (orig.) [de

Review: domestic animal forensic genetics - biological evidence, genetic markers, analytical approaches and challenges.

Science.gov (United States)

Kanthaswamy, S

2015-10-01

handling, evidence testing, statistical analysis and reporting that meet the rules of scientific acceptance, reliability and human forensic identification standards. © 2015 Stichting International Foundation for Animal Genetics.

Ernst Rüdin, 1874-1952: a German psychiatrist and geneticist.

Science.gov (United States)

Weber, M M

1996-07-26

Ernst Rüdin (1874-1952) was one of the major representatives of German psychiatry, genetics, and eugenics in the first half of the twentieth century. Born in Switzerland, he was influenced early on by his brother-in-law Alfred Ploetz, who propagated the ideas of social Darwinism and "racial hygiene" in Germany after 1890. Rüdin began his career in psychiatry at Emil Kraepelin's clinic in Munich, where he developed the concept of "empirical genetic prognosis" of mental disorders. He published his first results on the genetics of schizophrenia in 1916. From 1917-1945 Rüdin was director of the Genealogical-Demographic Department at the German Institute for Psychiatric Research, which Kraepelin had founded. After a short interruption from 1925-1928, Rüdin returned to Munich and enlarged the department. After 1933 the National Socialist government and party endorsed Rüdin's work by supplying financial and manpower support. Nazi health policy required a scientific basis to justify its actions, and Rüdin's ideas corresponded partially with this kind of thinking. In 1934 he prepared the official commentary on the "Law for the Prevention of Genetically Diseased Offspring." The connections of Rüdin's department to National Socialism can be understood as one of the main reasons for the critical attitude towards psychiatric genetics in Germany after 1945.

[Required Framework for the Collection of Real-life Data: An Example from University Eye Hospital Munich].

Science.gov (United States)

Kortüm, Karsten; Kern, Christoph; Meyer, Gerhard; Priglinger, Siegfried; Hirneiß, Christoph

2017-12-01

Background The importance of evaluating real-life data is constantly increasing. Currently available computer systems better allow for analyses of data, as more and more data is available in a digital form. Before a project for real-life data analyses is started, technical considerations and staff, legal, and data protection procedures need to be addressed. In this manuscript, experiences made at the University Eye Hospital in Munich will be shared. Materials and Methods Legal requirements, as found in laws and guidelines governing documentation and data privacy, are highlighted. Technical requirements for information technology infrastructure and software are defined. A survey conducted by the German Ophthalmological Society, among German eye hospitals investigating the current state of digitalization, was conducted. Also, staff requirements are outlined. Results A database comprising results of 330,801 patients was set up. It includes all diagnoses, procedures, clinical findings and results from diagnostic devices. This database was approved by the local data protection officer. In less than half of German eye hospitals (n = 21) that participated in the survey (n = 54), a complete electronic documentation is done. Fourteen institutions are completely paper-based, and the remainder of the hospitals used a mixed system. Conclusion In this work, we examined the framework that is required to develop a comprehensive database containing real-life data from clinics. In future, these databases will become increasingly important as more and more innovation are made in decision support systems. The base for this is comprehensive and well-curated databases. Georg Thieme Verlag KG Stuttgart · New York.

78 FR 58612 - Genomic Medicine Program Advisory Committee, Notice of Meeting

Science.gov (United States)

2013-09-24

... make recommendations to the Secretary of Veterans Affairs on using genetic information to optimize... appropriate ethical oversight and protecting the privacy of Veterans. The meeting focus will be on developing infrastructure and guidelines for phenotyping and maintaining privacy and security of genomic information. The...

Plant regeneration and genetic transformation in Jatropha

KAUST Repository

Sujatha, M.

2012-07-01

Jatropha curcas, a non-edible oil bearing species with multiple uses, and considerable economic potential is emerging as a potential biofuel plant. The limited knowledge of this species, low and inconsistent yields, the narrow genetic variability, and vulnerability to insects and diseases are major constraints in successful cultivation of Jatropha as a biofuel crop. Hence, genetic improvement of Jatropha is essential by conventional and modern biotechnological tools to use as a viable alternative source of bio-diesel. Realising its potential as a bio-energy crop, in vitro regeneration methods have been established to meet the demand of large scale supply of superior clones, and also as a prelude for genetic improvement of the species through transgenic approaches. In this chapter, an overview of in vitro tissue culture and genetic transformation of Jatropha is discussed. © 2013 Springer Science+Business Media Dordrecht. All rights are reserved.

28. Annual Meeting of the European Environmental Mutagen Society

International Nuclear Information System (INIS)

1998-09-01

The 28 th Annual Meeting of the European Environmental Mutagen Society took place in Salzburg from September 7 th till September 11 th , 1998. A lot of presentations also dealt with many radiation effects on cells, chromosomal aberrations and genetic effects caused by radioactive irradiation. In vivo and in vitro experiments concerning radiation injuries and carcinomas are analyzed. (Cecil)

78 FR 11137 - Notice of Meeting of the National Organic Standards Board (NOSB)

Science.gov (United States)

2013-02-15

... the ad hoc Genetically Modified Organisms (GMO). The primary purpose of NOSB meetings is to provide an... of the implementation of the Organic Foods Production Act (7 U.S.C. 6501- 6522). The NOSB currently...

An autonomous energy concept for the new Munich airport: Heating and cooling by use of waste heat. Autarkes Energiekonzept fuer neuen Muenchner Flughafen: Heizen und Kuehlen mit Abwaerme

Energy Technology Data Exchange (ETDEWEB)

Schmid, W.

1991-11-01

The energy concept for the new Munich airport relies on seven cogeneration modules which total outputs of 11 MW (electric) and 12 MW (thermal). Six of the modules will be operated continuously to cover the basic demand. For economy reasons the plant primarly serves to generate electric power. The secondary heat production cycle includes a buffer storage for temporary heat storage in accordance with the different demand characteristics. Without interrupting the heat transfer the system may thus be disconnected during low-load hours to tap power from the public destribution network. In addition to the central airport management system a central-supplies management system is provided which, e.g. selects the most efficient energy sources and, thus, helps to optimize the power generation systems. (BWI).

Managing genetic diversity and society needs

Directory of Open Access Journals (Sweden)

Arthur da Silva Mariante

2008-07-01

Full Text Available Most livestock are not indigenous to Brazil. Several animal species were considered domesticated in the pre-colonial period, since the indigenous people manage them as would be typical of European livestock production. For over 500 years there have been periodic introductions resulting in the wide range of genetic diversity that for centuries supported domestic animal production in the country. Even though these naturalized breeds have acquired adaptive traits after centuries of natural selection, they have been gradually replaced by exotic breeds, to such an extent, that today they are in danger of extinction To avoid further loss of this important genetic material, in 1983 Embrapa Genetic Resources and Biotechnology decided to include conservation of animal genetic resources among its priorities. In this paper we describe the effort to genetically characterize these populations, as a tool to ensure their genetic variability. To effectively save the threatened local breeds of livestock it is important to find a niche market for each one, reinserting them in production systems. They have to be utilized in order to be conserved. And there is no doubt that due to their adaptive traits, the Brazilian local breeds of livestock can play an important role in animal production, to meet society needs.

Human genetic factors in tuberculosis: an update.

Science.gov (United States)

van Tong, Hoang; Velavan, Thirumalaisamy P; Thye, Thorsten; Meyer, Christian G

2017-09-01

Tuberculosis (TB) is a major threat to human health, especially in many developing countries. Human genetic variability has been recognised to be of great relevance in host responses to Mycobacterium tuberculosis infection and in regulating both the establishment and the progression of the disease. An increasing number of candidate gene and genome-wide association studies (GWAS) have focused on human genetic factors contributing to susceptibility or resistance to TB. To update previous reviews on human genetic factors in TB we searched the MEDLINE database and PubMed for articles from 1 January 2014 through 31 March 2017 and reviewed the role of human genetic variability in TB. Search terms applied in various combinations were 'tuberculosis', 'human genetics', 'candidate gene studies', 'genome-wide association studies' and 'Mycobacterium tuberculosis'. Articles in English retrieved and relevant references cited in these articles were reviewed. Abstracts and reports from meetings were also included. This review provides a recent summary of associations of polymorphisms of human genes with susceptibility/resistance to TB. © 2017 John Wiley & Sons Ltd.

28. Annual Meeting of the European Environmental Mutagen Society

Energy Technology Data Exchange (ETDEWEB)

NONE

1998-09-01

The 28{sup th} Annual Meeting of the European Environmental Mutagen Society took place in Salzburg from September 7{sup th} till September 11{sup th}, 1998. A lot of presentations also dealt with many radiation effects on cells, chromosomal aberrations and genetic effects caused by radioactive irradiation. In vivo and in vitro experiments concerning radiation injuries and carcinomas are analyzed. (Cecil)

Changes in cytogenetics and molecular genetics in acute myeloid leukemia from childhood to adult age groups.

Science.gov (United States)

Creutzig, Ursula; Zimmermann, Martin; Reinhardt, Dirk; Rasche, Mareike; von Neuhoff, Christine; Alpermann, Tamara; Dworzak, Michael; Perglerová, Karolína; Zemanova, Zuzana; Tchinda, Joelle; Bradtke, Jutta; Thiede, Christian; Haferlach, Claudia

2016-12-15

To obtain better insight into the biology of acute myeloid leukemia (AML) in various age groups, this study focused on the genetic changes occurring during a lifetime. This study analyzed the relation between age and genetics from birth to 100 years in 5564 patients with de novo AML diagnosed from 1998 to 2012 (1192 patients from nationwide pediatric studies [AML Berlin-Frankfurt-Münster studies 98 and 2004] and 4372 adults registered with the Munich Leukemia Laboratory). The frequencies of cytogenetic subgroups were age-dependent. Favorable subtypes (t(8;21), inv(16)/t(16;16), and t(15;17)) decreased in general from the pediatric age group (2 to groups ( 70 years; P age-specific incidence with age. Interestingly, the frequency of 11q23 abnormalities decreased from infants to older patients. The proportion of clinically relevant molecular aberrations of CCAAT/enhancer binding protein α, nucleophosmin (NPM1), and NPM1/fms-related tyrosine kinase 3-internal tandem duplication increased with age. Altogether, with the exclusion of infants, a significant decrease in the proportion of favorable cytogenetic subtypes and an increase in unfavorable cytogenetics were observed with increasing age. These findings indicate different mechanisms for the pathogenesis of AML; these different mechanisms also suggest directions for etiological research and contribute to the more unfavorable prognosis with increasing age. Cancer 2016;122:3821-3830. © 2016 American Cancer Society. © 2016 American Cancer Society.

Assessing the Recreation Value of Urban Woodland Using the Ecosystem Service Approach in Two Forests in the Munich Metropolitan Region

Directory of Open Access Journals (Sweden)

Gerd Lupp

2016-11-01

Full Text Available Recreation is considered an important ecosystem services (ES in urban woodlands and puts pressure on other ES. Visitor management strategies can be tools to safeguard biodiversity and ES. On-site data are necessary to evaluate the demand for outdoor recreation opportunities in urban woodlands, but also for providing more reliable values for monetization as a basis for multifunctional forest management, and for raising awareness for the importance of urban proximate forests. Such information can also be used for the assessment and monetization of socio-cultural ES, and hence, contribute to developing market-based mechanisms or to promoting these ES. In our paper, we demonstrate methods to describe recreational demand by collecting data from interviews and using camera traps in two forests in the north of Munich for visitor counting. Visitor numbers in the forests were much greater than rough estimations; visitors also had quite long travelling distances to the forests. Jogging or Nordic walking were proven to be important recreational activities. In some of the monitored locations, almost half of the recreationists carried out these sports. Depending on the method chosen, the calculative monetary value of recreation reached up to 15,440 Euro per hectare per year.

Paradox of schizophrenia genetics: is a paradigm shift occurring?

Directory of Open Access Journals (Sweden)

Doi Nagafumi

2012-05-01

Full Text Available Abstract Background Genetic research of schizophrenia (SCZ based on the nuclear genome model (NGM has been one of the most active areas in psychiatry for the past two decades. Although this effort is ongoing, the current situation of the molecular genetics of SCZ seems disappointing or rather perplexing. Furthermore, a prominent discrepancy between persistence of the disease at a relatively high prevalence and a low reproductive fitness of patients creates a paradox. Heterozygote advantage works to sustain the frequency of a putative susceptibility gene in the mitochondrial genome model (MGM but not in the NGM. Methods We deduced a criterion that every nuclear susceptibility gene for SCZ should fulfill for the persistence of the disease under general assumptions of the multifactorial threshold model. SCZ-associated variants listed in the top 45 in the SZGene Database (the version of the 23rd December, 2011 were selected, and the distribution of the genes that could meet or do not meet the criterion was surveyed. Results 19 SCZ-associated variants that do not meet the criterion are located outside the regions where the SCZ-associated variants that could meet the criterion are located. Since a SCZ-associated variant that does not meet the criterion cannot be a susceptibility gene, but instead must be a protective gene, it should be linked to a susceptibility gene in the NGM, which is contrary to these results. On the other hand, every protective gene on any chromosome can be associated with SCZ in the MGM. Based on the MGM we propose a new hypothesis that assumes brain-specific antioxidant defenses in which trans-synaptic activations of dopamine- and N-methyl-d-aspartate-receptors are involved. Most of the ten predictions of this hypothesis seem to accord with the major epidemiological facts and the results of association studies to date. Conclusion The central paradox of SCZ genetics and the results of association studies to date argue against

The 17{sup th} European photovoltaic solar energy conference and exhibition in Munich from a Swiss point of view; Die 17. europaeische Photovoltaikkonferenz in Muenchen aus Schweizer Sicht

Energy Technology Data Exchange (ETDEWEB)

Nowak, S.

2002-07-01

This report for the Swiss Federal Office of Energy (SFOE) summarises the photovoltaics (PV) conference and exhibition held in Munich in October 2001 from the Swiss point of view. The contributions made by representatives of Swiss institutions and companies are presented including papers on the progress being made in third generation crystalline and multi-crystalline silicon technology, amorphous and micro-crystalline silicon solar cells, thin film solar cells based on compound semiconductors and thermo-photovoltaics. Further papers deal with PV modules on the market, building-integrated solar power systems and new developments in PV systems technology. The exhibition that accompanied the conference, including the 12 Swiss exhibitors who were present, is reviewed as are international market developments. Contributions concerning the application of photovoltaics in developing countries are also reviewed.

Characterization of a solid deuterium converter for ultra-cold neutrons (UCN) in the framework of the Mini-D2 project at the FRM-II reactor in Munich

International Nuclear Information System (INIS)

Tortorella, D.

2007-01-01

Spontaneous breaking of fundamental symmetries is an attractive topic in modern particles physic. Understanding qualitative and quantitative the parameters involved in these kind of processes could help to explain the unbalanced presence in the universe of matter (baryons) with respect to antimatter (anti-baryons). Due to their intrinsic properties, ultra cold neutrons (UCN) are excellent candidates in experiments measuring with high level of accuracy parameters like the electric dipole moment (EDM), the axial-vector coupling constant (g A ), the neutron lifetime (τ n ) or in search of quantum effect of gravity. In this work are presented several contributions in the framework of the Mini-D2 project, an innovative strong UCN source under construction at the FRM-II reactor in Munich. An important component of this facility, the solid deuterium UCN converter, is one subject of the thesis. (orig.)

Genetic Variability of Myxoma Virus Genomes

Science.gov (United States)

Braun, Christoph; Thürmer, Andrea; Daniel, Rolf; Schultz, Anne-Kathrin; Bulla, Ingo; Schirrmeier, Horst; Mayer, Dietmar; Neubert, Andreas

2016-01-01

ABSTRACT Myxomatosis is a recurrent problem on rabbit farms throughout Europe despite the success of vaccines. To identify gene variations of field and vaccine strains that may be responsible for changes in virulence, immunomodulation, and immunoprotection, the genomes of 6 myxoma virus (MYXV) strains were sequenced: German field isolates Munich-1, FLI-H, 2604, and 3207; vaccine strain MAV; and challenge strain ZA. The analyzed genomes ranged from 147.6 kb (strain MAV) to 161.8 kb (strain 3207). All sequences were affected by several mutations, covering 24 to 93 open reading frames (ORFs) and resulted in amino acid substitutions, insertions, or deletions. Only strains Munich-1 and MAV revealed the deletion of 10 ORFs (M007L to M015L) and 11 ORFs (M007L to M008.1L and M149R to M008.1R), respectively. Major differences were observed in the 27 immunomodulatory proteins encoded by MYXV. Compared to the reference strain Lausanne, strains FLI-H, 2604, 3207, and ZA showed the highest amino acid identity (>98.4%). In strains Munich-1 and MAV, deletion of 5 and 10 ORFs, respectively, was observed, encoding immunomodulatory proteins with ankyrin repeats or members of the family of serine protease inhibitors. Furthermore, putative immunodominant surface proteins with homology to vaccinia virus (VACV) were investigated in the sequenced strains. Only strain MAV revealed above-average frequencies of amino acid substitutions and frameshift mutations. Finally, we performed recombination analysis and found signs of recombination in vaccine strain MAV. Phylogenetic analysis showed a close relationship of strain MAV and the MSW strain of Californian MYXV. However, in a challenge model, strain MAV provided full protection against lethal challenges with strain ZA. IMPORTANCE Myxoma virus (MYXV) is pathogenic for European rabbits and two North American species. Due to sophisticated strategies in immune evasion and oncolysis, MYXV is an important model virus for immunological and

GBD 2000 - Proceedings of the 4. annual meeting of 'Gesellschaft fuer Biologische Strahlenforschung'

International Nuclear Information System (INIS)

Eckardt-Schupp, F.; Ahne, F.; Kistler, M.

2000-01-01

The headings of the meeting were as follows: Radiation chemistry and micro beam irradiation; DNA radiation damage and biological models; DNA repair; genetic radiation effects; radiation effects and stress effects on gene expression; cellular radiobiology; radiobiology of tumors and normal tissues; epidemiology

Significance of genetic predisposition and genomic instability for individual sensitivity to radiation. Implications for radiation protection

International Nuclear Information System (INIS)

Heller, H.

2001-01-01

At its closed-door meeting on 20/21 January 2000 the Radiation Protection Committee dedicated much of its attention to the significance of genetic predisposition and genetic instability for individual radiation sensitivity and to the implication of this for radiation protection. The statements and contributions to the closing plenary discussion touched on many aspects of ethics, personal rights, occupational medicine and insurance issues relating to this subject, all of which extend far beyond the purely technical issues of radiation protection. The present volume contains the lecture manuscripts of the meeting as well as a summarising assessment by the Radiation Protection Committee [de

Potential benefits of genetic modification (GM) technology for food ...

African Journals Online (AJOL)

We assessed the perception of farmers towards potential adoption of genetic modification (GM) technology for improving health, food security and agricultural productivity using a semi-structured interview. A total sample of 54 small-scale farmers participated in 6 focus group meetings (FGMs) and 23 in-depth interviews at ...

Genetic educational needs and the role of genetics in primary care: a focus group study with multiple perspectives

Directory of Open Access Journals (Sweden)

van der Vleuten Cees

2011-02-01

Full Text Available Abstract Background Available evidence suggests that improvements in genetics education are needed to prepare primary care providers for the impact of ongoing rapid advances in genomics. Postgraduate (physician training and master (midwifery training programmes in primary care and public health are failing to meet these perceived educational needs. The aim of this study was to explore the role of genetics in primary care (i.e. family medicine and midwifery care and the need for education in this area as perceived by primary care providers, patient advocacy groups and clinical genetics professionals. Methods Forty-four participants took part in three types of focus groups: mono-disciplinary groups of general practitioners and midwives, respectively and multidisciplinary groups composed of a diverse set of experts. The focus group sessions were audio-taped, transcribed verbatim and analysed using content analysis. Recurrent themes were identified. Results Four themes emerged regarding the educational needs and the role of genetics in primary care: (1 genetics knowledge, (2 family history, (3 ethical dilemmas and psychosocial effects in relation to genetics and (4 insight into the organisation and role of clinical genetics services. These themes reflect a shift in the role of genetics in primary care with implications for education. Although all focus group participants acknowledged the importance of genetics education, general practitioners felt this need more urgently than midwives and more strongly emphasized their perceived knowledge deficiencies. Conclusion The responsibilities of primary care providers with regard to genetics require further study. The results of this study will help to develop effective genetics education strategies to improve primary care providers' competencies in this area. More research into the educational priorities in genetics is needed to design courses that are suitable for postgraduate and master programmes for

A Rapid Systematic Review of Outcomes Studies in Genetic Counseling.

Science.gov (United States)

Madlensky, Lisa; Trepanier, Angela M; Cragun, Deborah; Lerner, Barbara; Shannon, Kristen M; Zierhut, Heather

2017-06-01

As healthcare reimbursement is increasingly tied to value-of-service, it is critical for the genetic counselor (GC) profession to demonstrate the value added by GCs through outcomes research. We conducted a rapid systematic literature review to identify outcomes of genetic counseling. Web of Science (including PubMed) and CINAHL databases were systematically searched to identify articles meeting the following criteria: 1) measures were assessed before and after genetic counseling (pre-post design) or comparisons were made between a GC group vs. a non-GC group (comparative cohort design); 2) genetic counseling outcomes could be assessed independently of genetic testing outcomes, and 3) genetic counseling was conducted by masters-level genetic counselors, or non-physician providers. Twenty-three papers met the inclusion criteria. The majority of studies were in the cancer genetic setting and the most commonly measured outcomes included knowledge, anxiety or distress, satisfaction, perceived risk, genetic testing (intentions or receipt), health behaviors, and decisional conflict. Results suggest that genetic counseling can lead to increased knowledge, perceived personal control, positive health behaviors, and improved risk perception accuracy as well as decreases in anxiety, cancer-related worry, and decisional conflict. However, further studies are needed to evaluate a wider array of outcomes in more diverse genetic counseling settings.

Genetically modified (GM) crops: milestones and new advances in crop improvement.

Science.gov (United States)

Kamthan, Ayushi; Chaudhuri, Abira; Kamthan, Mohan; Datta, Asis

2016-09-01

New advances in crop genetic engineering can significantly pace up the development of genetically improved varieties with enhanced yield, nutrition and tolerance to biotic and abiotic stresses. Genetically modified (GM) crops can act as powerful complement to the crops produced by laborious and time consuming conventional breeding methods to meet the worldwide demand for quality foods. GM crops can help fight malnutrition due to enhanced yield, nutritional quality and increased resistance to various biotic and abiotic stresses. However, several biosafety issues and public concerns are associated with cultivation of GM crops developed by transgenesis, i.e., introduction of genes from distantly related organism. To meet these concerns, researchers have developed alternative concepts of cisgenesis and intragenesis which involve transformation of plants with genetic material derived from the species itself or from closely related species capable of sexual hybridization, respectively. Recombinase technology aimed at site-specific integration of transgene can help to overcome limitations of traditional genetic engineering methods based on random integration of multiple copy of transgene into plant genome leading to gene silencing and unpredictable expression pattern. Besides, recently developed technology of genome editing using engineered nucleases, permit the modification or mutation of genes of interest without involving foreign DNA, and as a result, plants developed with this technology might be considered as non-transgenic genetically altered plants. This would open the doors for the development and commercialization of transgenic plants with superior phenotypes even in countries where GM crops are poorly accepted. This review is an attempt to summarize various past achievements of GM technology in crop improvement, recent progress and new advances in the field to develop improved varieties aimed for better consumer acceptance.

Characterization of a solid deuterium converter for ultra-cold neutrons (UCN) in the framework of the Mini-D{sub 2} project at the FRM-II reactor in Munich

Energy Technology Data Exchange (ETDEWEB)

Tortorella, D.

2007-02-07

Spontaneous breaking of fundamental symmetries is an attractive topic in modern particles physic. Understanding qualitative and quantitative the parameters involved in these kind of processes could help to explain the unbalanced presence in the universe of matter (baryons) with respect to antimatter (anti-baryons). Due to their intrinsic properties, ultra cold neutrons (UCN) are excellent candidates in experiments measuring with high level of accuracy parameters like the electric dipole moment (EDM), the axial-vector coupling constant (g{sub A}), the neutron lifetime ({tau}{sub n}) or in search of quantum effect of gravity. In this work are presented several contributions in the framework of the Mini-D2 project, an innovative strong UCN source under construction at the FRM-II reactor in Munich. An important component of this facility, the solid deuterium UCN converter, is one subject of the thesis. (orig.)

When Darwin meets Lorenz: Evolving new chaotic attractors through genetic programming

International Nuclear Information System (INIS)

Pan, Indranil; Das, Saptarshi

2015-01-01

Highlights: •New 3D continuous time chaotic systems with analytical expressions are obtained. •The multi-gene genetic programming (MGGP) paradigm is employed to achieve this. •Extends earlier works for evolving generalised family of Lorenz attractors. •Over one hundred of new chaotic attractors along with their parameters are reported. •The MGGP method have the potential for finding other similar chaotic attractors. -- Abstract: In this paper, we propose a novel methodology for automatically finding new chaotic attractors through a computational intelligence technique known as multi-gene genetic programming (MGGP). We apply this technique to the case of the Lorenz attractor and evolve several new chaotic attractors based on the basic Lorenz template. The MGGP algorithm automatically finds new nonlinear expressions for the different state variables starting from the original Lorenz system. The Lyapunov exponents of each of the attractors are calculated numerically based on the time series of the state variables using time delay embedding techniques. The MGGP algorithm tries to search the functional space of the attractors by aiming to maximise the largest Lyapunov exponent (LLE) of the evolved attractors. To demonstrate the potential of the proposed methodology, we report over one hundred new chaotic attractor structures along with their parameters, which are evolved from just the Lorenz system alone

Contributions to the 11. Geoengineering Congress in Munich. Geoengineering and energy; Beitraege zum 11. Geotechnik-Tag in Muenchen. Geotechnik und Energie

Energy Technology Data Exchange (ETDEWEB)

Vogt, Norbert (ed.)

2012-11-01

Within the eleventh geotechnics conference at 09th March, 2012 in Munich (Federal Republic of Germany), the following lectures were held: (1) New construction of the highway A44 on a new open pit dump (N. Vogt); (2) Soil liquefaction issues at mining dumps in the Lausitz (Wolfram Kudla); (3) Underfloor pumped-storage power plants in facilities of hard coal minings (Eugen Perau); (4) Geothermal energy power plant trademark (H. Haemmerle); (5) Surface settlements during the tunnel heading in the loose rock - prognosis, measurement and impact (J. Fillibeck); (6) Ring wall storages - an essential contribution to geotechnics for energy storage (M. Popp); (7) Storage basins and their geotechnical challenges (S. Messerklinger); (8) Energy from the Andes: The hydroelectric power plant La Confluencia in Chile (M. Mueller); (9) Particularities of geotechnical verifications for flat foundations of offshore wind power plants (U. Hartwig); (10) Dimensioning of piles for the foundation of offshore wind power plants (M. Achmus); (11) Offshore wind power fundaments: Practical experiences from the projects London Array and Dan Tysk (M. Horn); (12) Installation of a mono pile as a foundation structure for a tide turbine (S. Schmitz); (13) Carbon footprint - International comparison of assessment approaches at specialist foundation engineering techniques (A. Zoehrer); (14) Geotechnical assessments of upgrading power transmission lines (A. Smith).

Genetic susceptibility to environmental toxicants

DEFF Research Database (Denmark)

2001-01-01

The toxicological challenges to the chemical industry have in recent years been greatly affected by the rapid innovation and development of analytical, molecular and genetic technologies. ECETOC recognises the importance of developing the technical and intellectual skill bases in academia...... and industrial based laboratories to meet the rapid development of the science base of toxicology. As the technology to determine genetic susceptibility develops, so scientist will be able to describe altered gene expression provoked by chemicals long before they are able to offer valid interpretations...... to take toxicological data and both interpret and extrapolate it in a manner as to cause exaggerated concern. The challenge to the toxicologist is to explain what data means and in a way that inspires the confidence in those who have to apply data to the assessment of hazard and risk management. It seems...

Quality control in nuclear medicine. Addendum to 'Quality assurance in nuclear medicine', World Health Organization, 1982. Following a training workshop in Neuherberg, Munich, Federal Republic of Germany, November 23-30, 1983

International Nuclear Information System (INIS)

Cradduck, T.D.; Busemann Sokole, E.

2006-01-01

Based on the results of a workshop, sponsored by the German Federal Ministry of the Interior (BMI) and the World Health Organization (WHO), held in Neuherberg, Munich, 1983, a revised concept of quality control (QC) in nuclear medicine is proposed. In a previous document published by the WHO in 1982, a set of rigorous daily, weekly, monthly, quarterly and half-quarterly QC protocols was recommended. The revised concept suggested by the 1983 workshop participants is that of a simple, total system, QC test that can be applied on a frequent, probably daily, basis. Any deviation of the results of such a test from the accepted norm will require further investigation and decision trees can then be applied to localize faults

Report by the scientific secretary on major IAEA activities during 1989-1991

International Nuclear Information System (INIS)

Kossilov, A.

1992-01-01

Major IAEA activities in the field of nuclear power plant control and instrumentation in 1989-1991 are described: IAEA/OECD/NEA International Symposium on ''Balancing Automation and Human Action in Nuclear Power Plants'', Munich, Germany, 9-13 July 1990; specialists meetings; cooperation with OECD/NEA; a Review Report on ''Control Rooms and Man-Machine Interface in Nuclear Power Plants''; Advisory Group Meeting on ''The Balance Between Automation and Human Actions in NPP Operation''; use of simulators for training and maintaining competence; the guidelines for control room design; operator support systems in NPPs

DNA commission of the International Society for Forensic Genetics

DEFF Research Database (Denmark)

Gill, P; Brenner, C H; Buckleton, J S

2006-01-01

The DNA commission of the International Society of Forensic Genetics (ISFG) was convened at the 21st congress of the International Society for Forensic Genetics held between 13 and 17 September in the Azores, Portugal. The purpose of the group was to agree on guidelines to encourage best practice...... a consensus from experts but to be practical we do not claim to have conveyed a clear vision in every respect in this difficult subject. For this reason, we propose to allow a period of time for feedback and reflection by the scientific community. Then the DNA commission will meet again to consider further...

Vaccination: Developing and implementing a competency-based-curriculum at the Medical Faculty of LMU Munich

Directory of Open Access Journals (Sweden)

Vogel, B.

2016-02-01

Full Text Available Background: In Germany medical students should gain proficiency and specific skills in the vaccination field. Especially important is the efficient communication of scientific results about vaccinations to the community, in order to give professional counseling with a complete overview about therapeutic options.Aim of the project: The aim of this project is to set up a vaccination-related curriculum in the Medical Faculty at the Ludwig-Maximilians-University in Munich. The structure of the curriculum is based on the National catalogue for competency-based learning objectives in the field of vaccination (Nationaler Kompetenzbasierter Lernzielekatalog Medizin NKLM. Through this curriculum, the students will not only acquire the classical educational skills concerning vaccination in theory and practice, but they will also learn how to become independent in the decision-making process and counseling. Moreover, the students will become aware of consequences of action related to this specific topic.Methods: According to defined guidelines, an analysis was performed on courses, which are currently offered by the university. A separate analysis of the NKLM was carried out. Both analyses identified the active courses related to the topic of vaccination as well as the NKLM learning objectives. The match between the topics taught in current courses and the NKLM learning objectives identified gaps concerning the teaching of specific content. Courses were modified in order to implement the missing NKLM learning objectives.Results: These analyses identified 24 vaccination-related courses, which are currently taught at the University. Meanwhile, 35 learning objectives on vaccination were identified in the NKLM catalogue. Four of which were identified as not yet part of the teaching program. In summary, this interdisciplinary work enabled the development of a new vaccination-related curriculum, including 35 learning objectives, which are now implemented in

“French Phage Network”—Second Meeting Report

Science.gov (United States)

Torres-Barceló, Clara; Kaltz, Oliver; Froissart, Rémy; Gandon, Sylvain; Ginet, Nicolas; Ansaldi, Mireille

2017-01-01

The study of bacteriophages (viruses of bacteria) includes a variety of approaches, such as structural biology, genetics, ecology, and evolution, with increasingly important implications for therapeutic and industrial uses. Researchers working with phages in France have recently established a network to facilitate the exchange on complementary approaches, but also to engage new collaborations. Here, we provide a summary of the topics presented during the second meeting of the French Phage Network that took place in Marseille in November 2016. PMID:28430166

National Survey: Genetic Knowledge Of Danish Nurses – Needs And Reality

DEFF Research Database (Denmark)

Christiansen, Karin; Mikkelsen, Thomas Raundahl; Nissen, Kari Konstantin

The continuous progress in opportunities within whole genome sequencing, genomic assays, and development of low-cost genetic techniques presents the Danish healthcare system with new prospects and challenges. One of these is the growing need for all healthcare personnel to have knowledge of basic...... genetics, diagnostic principles, and insight into ethical, judicial and socioeconomic aspects of genetic diagnostics and testing. Nurses are often regarded as the health professionals whom the patient trusts to provide and make sense of genetic information. They would often be called upon to provide...... further clarification, give information about future prospects and support the patient in his or her reflections about the possible ethical and social implications of this information for the index person as well as the relatives. Whether the Danish nursing education is meeting these demands is not clear...

[Compatibility of Work and Family Life: Survey of Physicians in the Munich Metropolitan Area].

Science.gov (United States)

Lauchart, Meike; Ascher, Philipp; Kesel, Karin; Weber, Sabine; Grabein, Beatrice; Schneeweiss, Bertram; Fischer-Truestedt, Cordula; Schoenberg, Michael; Rogler, Gudrun; Borelli, Claudia

2017-05-15

Aim Investigation of the compatibility of work and family life for physicians in the Munich metropolitan area. Methods Survey of a representative sample of 1,800 physicians using a questionnaire. Results Men were less satisfied (7% very satisfied vs. 21%) with compatibility between work and family life than women. The group least satisfied overall was hospital-based physicians (p=0.000, chi-square=122.75). Women rather than men cut back their career due to children, perceived their professional advancement as impaired, desisted from establishing private practice or quit hospital employment altogether. Respondents strove for flexible childcare and makeshift solution if the established service failed. Most did not have that at their disposal. Hospital-based physicians wished for predictable working hours, and would like to have a say in the structure of their schedule. For the majority this was not the case. While for 80% it would be important to participate in the definition of their working hours, this was only possible in 17%. 86% found the opportunity to work part-time important, but many doctors (more than 30%) did not have that option. The biggest help for office-based physicians would be an expedited procedure by the Bavarian Association of Statutory Health Insurance Physicians (KVB) when applying for a proxy. The second most important would be the ability to hand over on-call duties. 36% of respondents felt that compatibility of work and family life was best achieved outside of patient care, during residency 42% believed this to be the case. Only 6% of physicians felt the best compatibility to be achieved in a hospital. Among the physician owners of practices, 34% considered their model to be the best way to reconcile both aspects of life. Conclusion More flexible options for childcare and more influence on the definition of working hours are necessary in order to better reconcile work and family life. For office-based physicians it must be made easier to

Genetic differences in the serum proteome of horses, donkeys and mules are detectable by protein profiling.

Science.gov (United States)

Henze, Andrea; Aumer, Franziska; Grabner, Arthur; Raila, Jens; Schweigert, Florian J

2011-10-01

Although horses and donkeys belong to the same genus, their genetic characteristics probably result in specific proteomes and post-translational modifications (PTM) of proteins. Since PTM can alter protein properties, specific PTM may contribute to species-specific characteristics. Therefore, the aim of the present study was to analyse differences in serum protein profiles of horses and donkeys as well as mules, which combine the genetic backgrounds of both species. Additionally, changes in PTM of the protein transthyretin (TTR) were analysed. Serum protein profiles of each species (five animals per species) were determined using strong anion exchanger ProteinChips® (Bio-Rad, Munich, Germany) in combination with surface-enhanced laser desorption ionisation-time of flight MS. The PTM of TTR were analysed subsequently by immunoprecipitation in combination with matrix-assisted laser desorption ionisation-time of flight MS. Protein profiling revealed species-specific differences in the proteome, with some protein peaks present in all three species as well as protein peaks that were unique for donkeys and mules, horses and mules or for horses alone. The molecular weight of TTR of horses and donkeys differed by 30 Da, and both species revealed several modified forms of TTR besides the native form. The mass spectra of mules represented a merging of TTR spectra of horses and donkeys. In summary, the present study indicated that there are substantial differences in the proteome of horses and donkeys. Additionally, the results probably indicate that the proteome of mules reveal a higher similarity to donkeys than to horses.

39 CFR 6.1 - Regular meetings, annual meeting.

Science.gov (United States)

2010-07-01

... 39 Postal Service 1 2010-07-01 2010-07-01 false Regular meetings, annual meeting. 6.1 Section 6.1 Postal Service UNITED STATES POSTAL SERVICE THE BOARD OF GOVERNORS OF THE U.S. POSTAL SERVICE MEETINGS (ARTICLE VI) § 6.1 Regular meetings, annual meeting. The Board shall meet regularly on a schedule...

75 FR 30046 - National Institute of Allergy and Infectious Diseases; Notice of Closed Meetings

Science.gov (United States)

2010-05-28

... Allergy and Infectious Diseases Special Emphasis Panel; Genetics Autoimmunity. Date: June 22, 2010. Time... Allergy and Infectious Diseases; Notice of Closed Meetings Pursuant to section 10(d) of the Federal... Infectious Diseases Special Emphasis Panel; Review of proposals received in response to NIH-NHLBI-HB-11-02...

76 FR 9030 - National Institute of Allergy and Infectious Diseases; Notice of Closed Meetings

Science.gov (United States)

2011-02-16

... Allergy and Infectious Diseases Special Emphasis Panel; Genetics of Lupus. Date: March 11, 2011. Time: 11... Allergy and Infectious Diseases; Notice of Closed Meetings Pursuant to section 10(d) of the Federal... Infectious Diseases Special Emphasis Panel; Ancillary Studies in Immunomodulation Clinical Trials (R01). Date...

75 FR 12769 - National Institute of Allergy and Infectious Diseases; Notice of Closed Meeting

Science.gov (United States)

2010-03-17

... Infectious Diseases Special Emphasis Panel; HLA Region Genetics in Immune- Mediated Diseases. Date: April 7-8... Allergy and Infectious Diseases; Notice of Closed Meeting Pursuant to section 10(d) of the Federal... Research; 93.856, Microbiology and Infectious Diseases Research, National Institutes of Health, HHS) Dated...

76 FR 10040 - National Institute of Neurological Disorders and Stroke; Notice of Closed Meetings

Science.gov (United States)

2011-02-23

... Disorders and Stroke Special Emphasis Panel, Neural Development and Genetics of Zebrafish. Date: February 25... Neurological Disorders and Stroke; Notice of Closed Meetings Pursuant to section 10(d) of the Federal Advisory... Institute of Neurological Disorders and Stroke Special Emphasis Panel, Specials Review Panel. Date: March 24...

[Requirements for final year medical studies in the era of generation Y - implementation for general and visceral surgery at the Ludwig Maximilians University of Munich].

Science.gov (United States)

Albertsmeier, M; Pratschke, S; Raes, P; Werner, J; Angele, M K

2014-12-01

The revision of the medical licensing regulations in 2012 has changed the underlying conditions for the practical year (PY), especially in the sense of markedly more flexibility for the medical students. The driving force for these and future changes, however, is not the legislature but rather the students themselves who are explicitly demanding that their training be adapted to their requirements and wishes. Time for the realisation of personal aims, planning of leisure time activities, for the family and social contacts as well as an altogether balanced work-life balance have replaced the wish for professional advancement as premise for the lifestyle of generation Y. Many hospitals, especially the privately-supported, attract students with special offers - university hospitals are called upon to defend their position in the competition for newly qualified students. The present article describes the changes of 2012 as part of a programme for a sustainable increase in the attractivity of the surgical PY at the Ludwig-Maximilian University (LMU) in Munich. Georg Thieme Verlag KG Stuttgart · New York.

Twenty-Seventh Fungal Genetics Conference, Asilomar, CA, March 12-17, 2013

Energy Technology Data Exchange (ETDEWEB)

Walton, Jonathan

2013-03-17

This meeting brings together ~900 international scientists to discuss the latest research on fungal genetics. Sessions of particular relevance to DOE include lignocellulose degradation, cellulose conversion to fermentable sugars, fermentation of sugars to fuel molecules. Other sessions cover fungal diseases of biomass crops (miscanthus, corn, switchgrass, etc.).

Linking pre-meeting communication to meeting effectiveness

NARCIS (Netherlands)

Allen, J.A.; Lehmann-Willenbrock, N.K.; Landowski, N.

2014-01-01

Purpose – The purpose of this paper is to investigate the importance of communication that occurs just before workplace meetings (i.e. pre-meeting talk). The paper explores how four specific types of pre-meeting talk (small talk, work talk, meeting preparatory talk, and shop talk) impact

Meeting report for mobile DNA 2010.

Science.gov (United States)

Chaconas, George; Craig, Nancy; Curcio, M Joan; Deininger, Prescott; Feschotte, Cedric; Levin, Henry; Rice, Phoebe A; Voytas, Daniel F

2010-08-24

An international conference on mobile DNA was held 24-28 April 2010 in Montreal, Canada. Sponsored by the American Society for Microbiology, the conference's goal was to bring together researchers from around the world who study transposition in diverse organisms using multiple experimental approaches. The meeting drew over 190 attendees and most contributed through poster presentations, invited talks and short talks selected from poster abstracts. The talks were organized into eight scientific sessions, which ranged in topic from the evolutionary dynamics of mobile genetic elements to transposition reaction mechanisms. Here we present highlights from the platform sessions with a focus on talks presented by the invited speakers.

Meeting Report for Mobile DNA 2010

Directory of Open Access Journals (Sweden)

Chaconas George

2010-08-01

Full Text Available Abstract An international conference on mobile DNA was held 24-28 April 2010 in Montreal, Canada. Sponsored by the American Society for Microbiology, the conference's goal was to bring together researchers from around the world who study transposition in diverse organisms using multiple experimental approaches. The meeting drew over 190 attendees and most contributed through poster presentations, invited talks and short talks selected from poster abstracts. The talks were organized into eight scientific sessions, which ranged in topic from the evolutionary dynamics of mobile genetic elements to transposition reaction mechanisms. Here we present highlights from the platform sessions with a focus on talks presented by the invited speakers.

Genetics meets metabolomics: a genome-wide association study of metabolite profiles in human serum.

Directory of Open Access Journals (Sweden)

Christian Gieger

2008-11-01

Full Text Available The rapidly evolving field of metabolomics aims at a comprehensive measurement of ideally all endogenous metabolites in a cell or body fluid. It thereby provides a functional readout of the physiological state of the human body. Genetic variants that associate with changes in the homeostasis of key lipids, carbohydrates, or amino acids are not only expected to display much larger effect sizes due to their direct involvement in metabolite conversion modification, but should also provide access to the biochemical context of such variations, in particular when enzyme coding genes are concerned. To test this hypothesis, we conducted what is, to the best of our knowledge, the first GWA study with metabolomics based on the quantitative measurement of 363 metabolites in serum of 284 male participants of the KORA study. We found associations of frequent single nucleotide polymorphisms (SNPs with considerable differences in the metabolic homeostasis of the human body, explaining up to 12% of the observed variance. Using ratios of certain metabolite concentrations as a proxy for enzymatic activity, up to 28% of the variance can be explained (p-values 10(-16 to 10(-21. We identified four genetic variants in genes coding for enzymes (FADS1, LIPC, SCAD, MCAD where the corresponding metabolic phenotype (metabotype clearly matches the biochemical pathways in which these enzymes are active. Our results suggest that common genetic polymorphisms induce major differentiations in the metabolic make-up of the human population. This may lead to a novel approach to personalized health care based on a combination of genotyping and metabolic characterization. These genetically determined metabotypes may subscribe the risk for a certain medical phenotype, the response to a given drug treatment, or the reaction to a nutritional intervention or environmental challenge.

Meetings and meeting modeling in smart surroundings

NARCIS (Netherlands)

op den Akker, Hendrikus J.A.; Heylen, Dirk K.J.; Nijholt, Antinus; Nishida, T.

2004-01-01

In this paper we survey our research on smart meeting rooms and its relevance for augmented reality meeting support and virtual reality generation of meetings in real-time or off-line. Intelligent real-time and off-line generation requires understanding of what is going on during a meeting. The

Meetings and Meeting Modeling in Smart Environments

NARCIS (Netherlands)

Nijholt, Antinus; op den Akker, Hendrikus J.A.; Heylen, Dirk K.J.

In this paper we survey our research on smart meeting rooms and its relevance for augmented reality meeting support and virtual reality generation of meetings in real time or off-line. The research reported here forms part of the European 5th and 6th framework programme projects multi-modal meeting

Amount of Genetics Education is Low Among Didactic Programs in Dietetics.

Science.gov (United States)

Beretich, Kaitlan; Pope, Janet; Erickson, Dawn; Kennedy, Angela

2017-01-01

Nutritional genomics is a growing area of research. Research has shown registered dietitian nutritionists (RDNs) have limited knowledge of genetics. Limited research is available regarding how didactic programs in dietetics (DPDs) meet the genetics knowledge requirement of the Accreditation Council for Education in Nutrition and Dietetics (ACEND®). The purpose of this study was to determine the extent to which the study of nutritional genomics is incorporated into undergraduate DPDs in response to the Academy of Nutrition and Dietetics position statement on nutritional genomics. The sample included 62 DPD directors in the U.S. Most programs (63.9%) reported the ACEND genetics knowledge requirement was being met by integrating genetic information into the current curriculum. However, 88.7% of programs reported devoting only 1-10 clock hours to genetics education. While 60.3% of directors surveyed reported they were confident in their program's ability to teach information related to genetics, only 6 directors reported having specialized training in genetics. The overall amount of clock hours devoted to genetics education is low. DPD directors, faculty, and instructors are not adequately trained to provide this education to students enrolled in DPDs. Therefore, the primary recommendation of this study is the development of a standardized curriculum for genetics education in DPDs.

FY 1999 project on the development of new industry support type international standards. Standardization of evaluation method of the genetic testing system (Separate volume); 1999 nendo shinki sangyo shiengata kokusai hyojunka kaihatsu jigyo seika hokokusho. Idenshi kensa system no hyoka hoho no hyojunka (bessatsu)

Energy Technology Data Exchange (ETDEWEB)

NONE

2000-03-01

The separate volume included the proceedings of the re-consignee joint meeting on the standardization of evaluation method of the genetic testing system, the proceedings/data of the meeting of the committee of the standardization of evaluation method of the genetic testing system, etc. The data of the meeting are about a plan to execute the standardization of evaluation method of the genetic testing system, standardization of forms for reporting the results of the genetic test, a trial guideline for standardization of the genetic testing, standardization of evaluation method of the genetic testing system, etc. Moreover, the volume included 11 literature papers overseas on the above-mentioned themes, 'reports on the surveys in Europe and the U.S. on the standardization of evaluation method of the genetic testing system,' etc. (NEDO)

FY 1999 project on the development of new industry support type international standards. Standardization of evaluation method of the genetic testing system (Separate volume); 1999 nendo shinki sangyo shiengata kokusai hyojunka kaihatsu jigyo seika hokokusho. Idenshi kensa system no hyoka hoho no hyojunka (bessatsu)

Energy Technology Data Exchange (ETDEWEB)

NONE

2000-03-01

The separate volume included the proceedings of the re-consignee joint meeting on the standardization of evaluation method of the genetic testing system, the proceedings/data of the meeting of the committee of the standardization of evaluation method of the genetic testing system, etc. The data of the meeting are about a plan to execute the standardization of evaluation method of the genetic testing system, standardization of forms for reporting the results of the genetic test, a trial guideline for standardization of the genetic testing, standardization of evaluation method of the genetic testing system, etc. Moreover, the volume included 11 literature papers overseas on the above-mentioned themes, 'reports on the surveys in Europe and the U.S. on the standardization of evaluation method of the genetic testing system,' etc. (NEDO)

The likely financial effects on individuals, industry and commerce of the use of genetic information.

Science.gov (United States)

Ross, T

1997-08-29

In this paper I look at the financial implications of genetic testing, particularly in the employment and pensions fields. I have generally not covered life insurance, as that is covered in other papers in this Discussion Meeting. However, the issues are similar, although the emphasis is different. Inevitably there is an element of speculation involved; genetic testing is in its infancy and so we cannot predict either what information we will be able to obtain through genetic testing, nor the uses that may be devised for this information.

21st Nantes Actualités Transplantation: "When Stem Cells Meet Immunology".

Science.gov (United States)

Anegon, Ignacio; Nguyen, Tuan Huy

2017-01-01

"When Stem Cells Meet Immunology" has been the topic of the 21st annual "Nantes Actualités en Transplantation" meeting (June 9-10, 2016, Nantes, France). This meeting brought together pioneers and leading experts in the fields of stem cells, biomaterials and immunoregulation. Presentations covered multipotent (mesenchymal and hematopoietic) and pluripotent stem cells (embryonic and induced) for regenerative medicine of incurable diseases, immunotherapy and blood transfusions. An additional focus had been immune rejections and responses of allogeneic or autologous stem cells. Conversely, stem cells are also able to directly modulate the immune response through the production of immunoregulatory molecules. Moreover, stem cells may also provide an unlimited source of immune cells (DCs, NK cells, B cells, and T cells) that can operate as "super" immune cells, for example, through genetic engineering with chimeric antigen receptors.This meeting report puts presentations into an overall context highlighting new potential biomarkers for potency prediction of mesenchymal stem cell-derived and pluripotent stem cell-derived multicellular organoids. Finally, we propose future directions arising from the flourishing encounter of stem cell and immune biology.

Genetic technologies to enhance the Sterile Insect Technique (SIT)

International Nuclear Information System (INIS)

Alphey, Luke; Baker, Pam; Condon, George C.; Condon, Kirsty C.; Dafa'alla, Tarig H.; Fu, Guoliang; Jin, Li; Labbe, Genevieve; Morrison, Neil M.; Nimmo, Derric D.; O'Connell, Sinead; Phillips, Caroline E.; Plackett, Andrew; Scaife, Sarah; Woods, Alexander; Burton, Rosemary S.; Epton, Matthew J.; Gong, Peng

2006-01-01

The Sterile Insect Technique (SIT) has been used very successfully against range of pest insects, including various tephritid fruit flies, several moths and a small number of livestock pests. However, modern genetics could potentially provide several improvements that would increase the cost-effectiveness of SIT, and extend the range of suitable species. These include improved identification of released individuals by incorporation of a stable, heritable, genetic marker; built-in sex separation (genetic sexing); reduction of the hazard posed by non-irradiated accidental releases from mass-rearing facility (fail-safe); elimination of the need for sterilization by irradiation (genetic sterilization). We discuss applications of these methods and the state of the art, at the time of this meeting, in developing suitable strains. We have demonstrated, in several key pest species, that the required strains can be constructed by introducing a repressible dominant lethal genetic system, a method known as RIDL(trade mark). Based on field experience with Medfly, incorporation of a genetic sexing system into SIT programs for other tephritids could potentially provide a very significant improvement in cost-effectiveness. We have now been able to make efficient female-lethal strains for Medfly. One advantage of our approach is that it should be possible rapidly to extend this technology to other fruit fly species; indeed we have recently been able also to make genetic sexing strains of Medfly (Anastrepha ludens). (author)

Genetic technologies to enhance the Sterile Insect Technique (SIT)

Energy Technology Data Exchange (ETDEWEB)

Alphey, Luke; Baker, Pam; Condon, George C; Condon, Kirsty C; Dafa' alla, Tarig H; Fu, Guoliang; Jin, Li; Labbe, Genevieve; Morrison, Neil M; Nimmo, Derric D; O' Connell, Sinead; Phillips, Caroline E; Plackett, Andrew; Scaife, Sarah; Woods, Alexander [Oxitec Ltd., Oxford (United Kingdom); Burton, Rosemary S; Epton, Matthew J; Gong, Peng [University of Oxford (United Kingdom). Dept. of Zoology

2006-07-01

The Sterile Insect Technique (SIT) has been used very successfully against range of pest insects, including various tephritid fruit flies, several moths and a small number of livestock pests. However, modern genetics could potentially provide several improvements that would increase the cost-effectiveness of SIT, and extend the range of suitable species. These include improved identification of released individuals by incorporation of a stable, heritable, genetic marker; built-in sex separation (genetic sexing); reduction of the hazard posed by non-irradiated accidental releases from mass-rearing facility (fail-safe); elimination of the need for sterilization by irradiation (genetic sterilization). We discuss applications of these methods and the state of the art, at the time of this meeting, in developing suitable strains. We have demonstrated, in several key pest species, that the required strains can be constructed by introducing a repressible dominant lethal genetic system, a method known as RIDL(trade mark). Based on field experience with Medfly, incorporation of a genetic sexing system into SIT programs for other tephritids could potentially provide a very significant improvement in cost-effectiveness. We have now been able to make efficient female-lethal strains for Medfly. One advantage of our approach is that it should be possible rapidly to extend this technology to other fruit fly species; indeed we have recently been able also to make genetic sexing strains of Medfly (Anastrepha ludens). (author)

Conference scene: DGVS spring conference 2009.

Science.gov (United States)

Kolligs, Frank Thomas

2009-10-01

The 3rd annual DGVS Spring Conference of the German Society for Gastroenterology (Deutsche Gesellschaft für Verdauungs- und Stoffwechselkrankheiten) was held at the Seminaris Campus Hotel in Berlin, Germany, on 8-9 May, 2009. The conference was organized by Roland Schmid and Matthias Ebert from the Technical University of Munich, Germany. The central theme of the meeting was 'translational gastrointestinal oncology: towards personalized medicine and individualized therapy'. The conference covered talks on markers for diagnosis, screening and surveillance of colorectal cancer, targets for molecular therapy, response prediction in clinical oncology, development and integration of molecular imaging in gastrointestinal oncology and translational research in clinical trial design. Owing to the broad array of topics and limitations of space, this article will focus on biomarkers, response prediction and the integration of biomarkers into clinical trials. Presentations mentioned in this summary were given by Matthias Ebert (Technical University of Munich, Germany), Esmeralda Heiden (Epigenomics, Berlin, Germany), Frank Kolligs (University of Munich, Germany), Florian Lordick (University of Heidelberg, Germany), Hans Jorgen Nielsen (University of Copenhagen, Denmark), Anke Reinacher-Schick (University of Bochum, Germany), Christoph Röcken (University of Berlin, Germany), Wolff Schmiegel (University of Bochum, Germany) and Thomas Seufferlein (University of Halle, Germany).

CMCpy: Genetic Code-Message Coevolution Models in Python

Science.gov (United States)

Becich, Peter J.; Stark, Brian P.; Bhat, Harish S.; Ardell, David H.

2013-01-01

Code-message coevolution (CMC) models represent coevolution of a genetic code and a population of protein-coding genes (“messages”). Formally, CMC models are sets of quasispecies coupled together for fitness through a shared genetic code. Although CMC models display plausible explanations for the origin of multiple genetic code traits by natural selection, useful modern implementations of CMC models are not currently available. To meet this need we present CMCpy, an object-oriented Python API and command-line executable front-end that can reproduce all published results of CMC models. CMCpy implements multiple solvers for leading eigenpairs of quasispecies models. We also present novel analytical results that extend and generalize applications of perturbation theory to quasispecies models and pioneer the application of a homotopy method for quasispecies with non-unique maximally fit genotypes. Our results therefore facilitate the computational and analytical study of a variety of evolutionary systems. CMCpy is free open-source software available from http://pypi.python.org/pypi/CMCpy/. PMID:23532367

[Evolutionary process unveiled by the maximum genetic diversity hypothesis].

Science.gov (United States)

Huang, Yi-Min; Xia, Meng-Ying; Huang, Shi

2013-05-01

As two major popular theories to explain evolutionary facts, the neutral theory and Neo-Darwinism, despite their proven virtues in certain areas, still fail to offer comprehensive explanations to such fundamental evolutionary phenomena as the genetic equidistance result, abundant overlap sites, increase in complexity over time, incomplete understanding of genetic diversity, and inconsistencies with fossil and archaeological records. Maximum genetic diversity hypothesis (MGD), however, constructs a more complete evolutionary genetics theory that incorporates all of the proven virtues of existing theories and adds to them the novel concept of a maximum or optimum limit on genetic distance or diversity. It has yet to meet a contradiction and explained for the first time the half-century old Genetic Equidistance phenomenon as well as most other major evolutionary facts. It provides practical and quantitative ways of studying complexity. Molecular interpretation using MGD-based methods reveal novel insights on the origins of humans and other primates that are consistent with fossil evidence and common sense, and reestablished the important role of China in the evolution of humans. MGD theory has also uncovered an important genetic mechanism in the construction of complex traits and the pathogenesis of complex diseases. We here made a series of sequence comparisons among yeasts, fishes and primates to illustrate the concept of limit on genetic distance. The idea of limit or optimum is in line with the yin-yang paradigm in the traditional Chinese view of the universal creative law in nature.

Mendel Meets CSI: Forensic Genotyping as a Method to Teach Genetics & DNA Science

Science.gov (United States)

Kurowski, Scotia; Reiss, Rebecca

2007-01-01

This article describes a forensic DNA science laboratory exercise for advanced high school and introductory college level biology courses. Students use a commercial genotyping kit and genetic analyzer or gene sequencer to analyze DNA recovered from a fictitious crime scene. DNA profiling and STR genotyping are outlined. DNA extraction, PCR, and…

Centro parroquial - Eching - Munich - Alemania federal

Directory of Open Access Journals (Sweden)

Haindl, Friedrich F.

1973-09-01

Full Text Available To stand out among the scattered urbanization in which it lies, this Parish Centre was designed as a group of independent buildings, distributed around a court-yard or atrium, and built on a rectangular design, intented, respectively, for the church, parish home and children's nursery. The church, due to its height, is the dominating feature of the whole. It has a main aisle, encircled by a less high passage, a small side chapel and the vestry. The parish home which is made up of a ground floor and semibasement, has, in the latter, a room for table tennis, two for groups and an area for heating the whole building. In the ground floor there is a parish hall with a stage and library. The children's nursery has the ground floor and a small basement, in which there are three stores and a workshop. The ground floor houses: the children's area, with two large rooms and a rest room; the teachers' area, with two rooms, toilets and kitchen; the services area, and finally, to complete the floor, an office and meeting room. The whole building has been made of whitewashed brick walls, contrasting with the large window panes.Para destacar de la urbanización dispersa en la que se haya enclavado, este Centro Parroquial se concibió como un grupo de edificios independientes, distribuidos alrededor de un patio de entrada o atrio, con planta rectangular de diferentes dimensiones, destinados, respectivamente, a iglesia, hogar parroquial y jardín de infancia. La Iglesia es, por su altura, el elemento dominante del conjunto. Consta de una nave central, circundada por un pasillo de menor altura, por una pequeña capilla lateral y por el grupo de la sacristía. El hogar parroquial, que cuenta con planta baja y semisótano, tiene en este último: una sala para ping-pong, dos para grupos, y la zona para la calefacción de todo el conjunto. En la planta baja hay un salón parroquial con escenario y una biblioteca. El jardín de Infancia dispone de planta baja y un

The Nordic Countries Meeting on the Zebrafish as a Model for Development and Disease 2012

Science.gov (United States)

Zetterberg, Henrik

2013-01-01

Abstract The first Nordic Countries Meeting on the Zebrafish as a Model for Development and Disease took place at Karolinska Institutet in Stockholm, November 21–23, 2012. The meeting gathered 130 scientists, students, and company representatives from Iceland, Finland, Norway, Denmark, and Sweden, as well as invited guests and keynote speakers from England, Scotland, Germany, Poland, The Netherlands, Singapore, Japan, and the United States. Presentations covered a wide range of topics, including developmental biology, genetics, evolutionary biology, toxicology, behavioral studies, and disease mechanisms. The need for formal guidance and training in zebrafish housing, husbandry, and health monitoring was recognized, and the meeting expressed its support for the joint working group of the FELASA/COST action BM0804 EuFishBioMed. The decision was made to turn the Nordic meeting into an annual event and create a Nordic network of zebrafish researchers. PMID:23590403

78 FR 2961 - Sunshine Act Meeting-Closed Meeting

Science.gov (United States)

2013-01-15

... COMMODITY FUTURES TRADING COMMISSION Sunshine Act Meeting--Closed Meeting The following notice of a closed meeting is published pursuant to the provisions of the Government in the Sunshine Act, Public Law 94- 409, 5 U.S.C. 552b. AGENCY HOLDING THE MEETING: Commodity Futures Trading Commission. TIME...

78 FR 6306 - Sunshine Act Meeting-Closed Meeting

Science.gov (United States)

2013-01-30

... COMMODITY FUTURES TRADING COMMISSION Sunshine Act Meeting--Closed Meeting The following notice of a closed meeting is published pursuant to the provisions of the Government in the Sunshine Act, Public Law 94- 409, 5 U.S.C. 552b. AGENCY HOLDING THE MEETING: Commodity Futures Trading Commission. TIME...

Radiological appearance from 250 patients of the Clinic and Policlinic for Radiology at the University of Munich with histologically detected bronchial carcinoma

International Nuclear Information System (INIS)

Bruckmayer, G.

1982-01-01

From 250 patients of the Clinic and Policlinic for Radiology at the University of Munich from 1975 to 1979 the radiomorphology of the central and peripheral bronchial carcinoma is demonstrated. The sex ratio of 6.3/1, the age distribution with its peak between 60 and 70 years of age and the localisations with a predominance in the right lung and a preferred infection of the upper lobes from our study agreed with the results from the literature. Characteristic early symptoms are missing with bronchial carcinoma, although clinical symptoms in the rule are the first evidence. For early recognition the first and easiest diagnostic procedure is the radiological examination of the thorax in two planes. Circular foci and peripheral tumor shadows, which occur with the spreading of the mediastinum or the hilus, in these patients about 50%, are in large amounts suspicious of a malignancy and indicate an advanced stage. Because the prognosis of the bronchial carcinoma depends on the histological structure of the tumor and on the point in time of diagnosis, an improvement of the life expectancy can only be reached by early detection. In the risk group of smokers over 40 years of age and of professionally exposed people, even minor changes should be considered as carcinoma until the opposite can be proven. (orig./TRV) [de

Using Genetic Buffering Relationships Identified in Fission Yeast To Elucidate the Molecular Pathology of Tuberous Sclerosis

Science.gov (United States)

2016-07-01

tsc1 and tsc2 loss of function mutations in Schizosaccharomyces pombe. Northeast Regional Yeast Meeting, June 16-17, University at Buffalo, The State...AWARD NUMBER: W81XWH-14-1-0169 TITLE: Using Genetic Buffering Relationships Identified in Fission Yeast To Elucidate the Molecular Pathology of...SUBTITLE Using Genetic Buffering Relationships Identified in Fission 5a. CONTRACT NUMBER W81XWH-14-1-0169 Yeast to Elucidate the Molecular Pathology

Meeting Disorders.

Science.gov (United States)

Yager, Joel; Katzman, Jeffrey W

2017-12-01

Although meetings are central to organizational work, considerable time devoted to meetings in Academic Health Centers appears to be unproductively spent. The primary purposes of this article are to delineate and describe Meeting Disorders, pathological processes resulting in these inefficient and ineffective scenarios, and Meeting Fatigue Disorder (MFD), a clinical syndrome. The paper also offers preliminary approaches to remedies. The authors integrate observations made during tens of thousands of hours in administrative meetings in academic medical settings with information in the literature regarding the nature, causes and potential interventions for dysfunctional groups and meetings. Meeting Disorders, resulting from distinct pathologies of leadership and organization, constitute prevalent subgroups of the bureaucrapathologies, pathological conditions caused by dysfunctional bureaucratic processes that generate excesses of wasted time, effort, and other resources. These disorders also generate frustration and demoralization among participants, contributing to professional burnout. Meeting Fatigue Disorder (MFD) is a subjective condition that develops in individuals who overdose on these experiences and may reflect one manifestation of burnout. Meeting disorders and Meeting Fatigue Disorder occur commonly in bureaucratic life. Resources and potential remedies are available to help ameliorate their more deleterious effects.

29 CFR 2701.2 - Open meetings policy; closure of meetings.

Science.gov (United States)

2010-07-01

... 29 Labor 9 2010-07-01 2010-07-01 false Open meetings policy; closure of meetings. 2701.2 Section... GOVERNMENT IN THE SUNSHINE ACT REGULATIONS § 2701.2 Open meetings policy; closure of meetings. (a) Policy. Commission meetings will generally be open to public observation, including meetings concerning the...

OnToPV - a virtual guidance through the PV-plant ''Solardach New Munich Trade Fair''; OnToPV - eine virtuelle Fuehrung druch die PV-Anlage ''Solardach Neue Messe Muenchen''

Energy Technology Data Exchange (ETDEWEB)

Stich, C.; Becker, G.; Zehner, M. [Fachhochschule Muenchen (Germany). Fachbereich Elektrotechnik; Giesler, B. [Shell Solar GmbH, Muenchen (Germany); Weber, W.; Flade, F. [Solarenergiefoerderverein Bayern e.V., Muenchen (Germany)

2003-07-01

OnToPV is the project of an online tour guide through the PV-plant of the new Munich trade fair. The first focs was to provide an interactive circuit of a PV-plant. Within a virtual tour different areas of the plant should be made accessible over the internet. For this purpose a three-dimensional, multimedia guidance was developed for the PV-plant of the new Munich trade fair with informative diagrams, *.pdf-files and retrievable video-files. In such a way interested internet-users could experience with minimum system requirements, local- and time-independently the PV-plant in its structure and components and could receive different background informations in addition. From the view of the plant operators such an internet project serves on the one hand as an additional source of information where questions could be referred to and on the other hand as sort of advertisement for the technology and the PV-system. In addition the attractiveness of the internet appearance of the plant operator rises and the public awareness of such projects could increase. Seen from the user perspective - such an internet project gives private or business users the possibility to inform themselves interactively, purposefully and with the possibility to move through the plant on their own. Users could utilize the guidance through the plant without overcoming far geographical distances, saving time and money. Perhaps this source of information helps awaking a larger consciousness for renewable energies. The result OnToPV showed the various possibilities offered by projects of this kind in the internet. Ideas of possible extensions as for example the integration of current PV-plant operational data or of a virtual learning platform illustrate the perspectives of the project. Virtual guidance of this kind for various types of power plants are conceivable. (orig.)

European Society of Nuclear Methods in Agriculture. XXIst annual meeting

International Nuclear Information System (INIS)

1990-09-01

The publication contains 148 submitted abstracts of contributions to be presented at the meeting in the following working groups: 1. food irradiation; 2. radiation-induced stimulation, effects in living organisms; 3/4. tracer techniques in animal sciences, physical methods; 5. soil-plant relationship; 6. applied mutagenesis; 7. environmental pollution; 8. energy in agriculture; 9/10. genetic methods in pest control, radionuclides in insect ecology; 11. nuclear methods in plant physiology; 12. waste irradiation. A list of participants is also included. (P.A.)

Democracy and genetic privacy: the value of bodily integrity.

Science.gov (United States)

Beckman, Ludvig

2005-01-01

The right to genetic privacy is presently being incorporated in legal systems all over the world. It remains largely unclear however what interests and values this right serves to protect. There are many different arguments made in the literature, yet none takes into account the problem of how particular values can be justified given the plurality of moral and religious doctrines in our societies. In this article theories of public reason are used in order to explore how genetic privacy could be justified in a way that is sensitive to the "fact of pluralism". The idea of public reason is specified as the idea that governments should appeal only to values and beliefs that are acceptable to all reasonable citizens in the justification of rights. In examining prevalent arguments for genetic privacy--based on the value of autonomy or on the value of intimacy--it is concluded that they do not meet this requirement. In dealing with this deficiency in the literature, an argument is developed that genetic privacy is fundamental to the democratic participation of all citizens. By referring to the preconditions of democratic citizenship, genetic privacy can be justified in a way that respects the plurality of comprehensive doctrines of morality and religion in contemporary societies.

75 FR 73083 - Sunshine Act Meeting; Open Commission Meeting

Science.gov (United States)

2010-11-29

... FEDERAL COMMUNICATIONS COMMISSION Sunshine Act Meeting; Open Commission Meeting November 30, 2010. The Federal Communications Commission will hold an Open Meeting on the subjects listed below on... demonstrate accessibility technologies. The meeting site is fully accessible to people using wheelchairs or...

A model-based approach to adjust microwave observations for operational applications: results of a campaign at Munich Airport in winter 2011/2012

Directory of Open Access Journals (Sweden)

J. Güldner

2013-10-01

Full Text Available In the frame of the project "LuFo iPort VIS" which focuses on the implementation of a site-specific visibility forecast, a field campaign was organised to offer detailed information to a numerical fog model. As part of additional observing activities, a 22-channel microwave radiometer profiler (MWRP was operating at the Munich Airport site in Germany from October 2011 to February 2012 in order to provide vertical temperature and humidity profiles as well as cloud liquid water information. Independently from the model-related aims of the campaign, the MWRP observations were used to study their capabilities to work in operational meteorological networks. Over the past decade a growing quantity of MWRP has been introduced and a user community (MWRnet was established to encourage activities directed at the set up of an operational network. On that account, the comparability of observations from different network sites plays a fundamental role for any applications in climatology and numerical weather forecast. In practice, however, systematic temperature and humidity differences (bias between MWRP retrievals and co-located radiosonde profiles were observed and reported by several authors. This bias can be caused by instrumental offsets and by the absorption model used in the retrieval algorithms as well as by applying a non-representative training data set. At the Lindenberg observatory, besides a neural network provided by the manufacturer, a measurement-based regression method was developed to reduce the bias. These regression operators are calculated on the basis of coincident radiosonde observations and MWRP brightness temperature (TB measurements. However, MWRP applications in a network require comparable results at just any site, even if no radiosondes are available. The motivation of this work is directed to a verification of the suitability of the operational local forecast model COSMO-EU of the Deutscher Wetterdienst (DWD for the calculation

The cold war context of the golden jubilee, or, why we think of mendel as the father of genetics.

Science.gov (United States)

Wolfe, Audra J

2012-01-01

In September 1950, the Genetics Society of America (GSA) dedicated its annual meeting to a "Golden Jubilee of Genetics" that celebrated the 50th anniversary of the rediscovery of Mendel's work. This program, originally intended as a small ceremony attached to the coattails of the American Institute of Biological Sciences (AIBS) meeting, turned into a publicity juggernaut that generated coverage on Mendel and the accomplishments of Western genetics in countless newspapers and radio broadcasts. The Golden Jubilee merits historical attention as both an intriguing instance of scientific commemoration and as an early example of Cold War political theatre. Instead of condemning either Lysenko or Soviet genetics, the Golden Jubilee would celebrate Mendel - and, not coincidentally, the practical achievements in plant and animal breeding his work had made possible. The American geneticists' focus on the achievements of Western genetics as both practical and theoretical, international, and, above all, non-ideological and non-controversial, was fully intended to demonstrate the success of the Western model of science to both the American public and scientists abroad at a key transition point in the Cold War. An implicit part of this article's argument, therefore, is the pervasive impact of the Cold War in unanticipated corners of postwar scientific culture.

sGD: software for estimating spatially explicit indices of genetic diversity.

Science.gov (United States)

Shirk, A J; Cushman, S A

2011-09-01

Anthropogenic landscape changes have greatly reduced the population size, range and migration rates of many terrestrial species. The small local effective population size of remnant populations favours loss of genetic diversity leading to reduced fitness and adaptive potential, and thus ultimately greater extinction risk. Accurately quantifying genetic diversity is therefore crucial to assessing the viability of small populations. Diversity indices are typically calculated from the multilocus genotypes of all individuals sampled within discretely defined habitat patches or larger regional extents. Importantly, discrete population approaches do not capture the clinal nature of populations genetically isolated by distance or landscape resistance. Here, we introduce spatial Genetic Diversity (sGD), a new spatially explicit tool to estimate genetic diversity based on grouping individuals into potentially overlapping genetic neighbourhoods that match the population structure, whether discrete or clinal. We compared the estimates and patterns of genetic diversity using patch or regional sampling and sGD on both simulated and empirical populations. When the population did not meet the assumptions of an island model, we found that patch and regional sampling generally overestimated local heterozygosity, inbreeding and allelic diversity. Moreover, sGD revealed fine-scale spatial heterogeneity in genetic diversity that was not evident with patch or regional sampling. These advantages should provide a more robust means to evaluate the potential for genetic factors to influence the viability of clinal populations and guide appropriate conservation plans. © 2011 Blackwell Publishing Ltd.

Genetic effects on information processing speed are moderated by age--converging results from three samples.

Science.gov (United States)

Ising, M; Mather, K A; Zimmermann, P; Brückl, T; Höhne, N; Heck, A; Schenk, L A; Rujescu, D; Armstrong, N J; Sachdev, P S; Reppermund, S

2014-06-01

Information processing is a cognitive trait forming the basis of complex abilities like executive function. The Trail Making Test (TMT) is a well-established test of information processing with moderate to high heritability. Age of the individual also plays an important role. A number of genetic association studies with the TMT have been performed, which, however, did not consider age as a moderating factor. We report the results of genome-wide association studies (GWASs) on age-independent and age-dependent TMT performance in two population-representative community samples (Munich Antidepressant Response Signature, MARS: N1 = 540; Ludwig Maximilians University, LMU: N2 = 350). Age-dependent genome-wide findings were then evaluated in a third sample of healthy elderly subjects (Sydney Memory and Ageing Study, Sydney MAS: N3 = 448). While a meta-analysis on the GWAS findings did not reveal age-independent TMT associations withstanding correction for multiple testing, we found a genome-wide significant age-moderated effect between variants in the DSG1 gene region and TMT-A performance predominantly reflecting visual processing speed (rs2199301, P(meta-analysis) = 1.3 × 10(-7)). The direction of the interaction suggests for the minor allele a beneficial effect in younger adults turning into a detrimental effect in older adults. The detrimental effect of the missense single nucleotide polymorphism rs1426310 within the same DSG1 gene region could be replicated in Sydney MAS participants aged 70-79, but not in those aged 80 years and older, presumably a result of survivor bias. Our findings demonstrate opposing effects of DSG1 variants on information processing speed depending on age, which might be related to the complex processes that DSG1 is involved with, including cell adhesion and apoptosis. © 2014 John Wiley & Sons Ltd and International Behavioural and Neural Genetics Society.

FENDL neutronics benchmark: Specifications for the calculational neutronics and shielding benchmark

International Nuclear Information System (INIS)

Sawan, M.E.

1994-12-01

During the IAEA Advisory Group Meeting on ''Improved Evaluations and Integral Data Testing for FENDL'' held in Garching near Munich, Germany in the period 12-16 September 1994, the Working Group II on ''Experimental and Calculational Benchmarks on Fusion Neutronics for ITER'' recommended that a calculational benchmark representative of the ITER design should be developed. This report describes the neutronics and shielding calculational benchmark available for scientists interested in performing analysis for this benchmark. (author)

Reevaluation of microplastics extraction efficiency with the aim of Munich Plastic Sediment Separator.

Science.gov (United States)

Zobkov, Mikhail; Esiukova, Elena; Grave, Aleksei; Khatmullina, Liliya

2017-04-01

Invading of microplastics into marine environment is known as a global ecological threat. Specific density of microplastics can vary significantly depending on a polymer type, technological processes of its production, additives, weathering, and biofouling. Plastic particles can sink or float on the sea surface, but with time, most of drifting plastics become negatively buoyant and sink to the sea floor due to biofouling or adherence of denser particles. As a result, the seabed becomes the ultimate repository for microplastic particles and fibres. A study of microplastics content in aquatic sediments is an important source of information about ways of their migration, sink and accumulation zones. The Munich Plastic Sediment Separator (MPSS), proposed by Imhoff et al. (2012), is considered as the most effective tool for microplastic extraction. However, we observed that the numbers of marine microplastics extracted with this tool from different kinds of bottom sediments were significantly underestimated. We examined the extraction efficiency of the MPSS by adding artificial reference particles (ARPs) to marine sediment sample before the extraction procedure. Extraction was performed by two different methods: the modified NOAA method and using the MPSS. The separation solution with specific density 1.5 g/ml was used. Subsequent cleaning, drying and microscope detection procedures were identical. The microplastics content was determined in supernatant fraction, in the bulk of the extraction solution, in spoil dump fraction of MPSS and in instrument wash-out. While the extraction efficiency from natural sediments of ARPs by the MPSS was really high (100% in most cases), the extraction efficiency of marine microplastics was up to 10 times lower than that obtained with modified NOAA method for the same samples. Less than 40% of the total marine microplastics content has been successfully extracted with the MPSS. Large amounts of marine microplastics were found in the

Tetralogy of Fallot and Hypoplastic Left Heart Syndrome – Complex Clinical Phenotypes Meet Complex Genetic Networks

Science.gov (United States)

Lahm, Harald; Schön, Patric; Doppler, Stefanie; Dreßen, Martina; Cleuziou, Julie; Deutsch, Marcus-André; Ewert, Peter; Lange, Rüdiger; Krane, Markus

2015-01-01

In many cases congenital heart disease (CHD) is represented by a complex phenotype and an array of several functional and morphological cardiac disorders. These malformations will be briefly summarized in the first part focusing on two severe CHD phenotypes, hypoplastic left heart syndrome (HLHS) and tetralogy of Fallot (TOF). In most cases of CHD the genetic origin remains largely unknown, though the complexity of the clinical picture strongly argues against a dysregulation which can be attributed to a single candidate gene but rather suggests a multifaceted polygenetic origin with elaborate interactions. Consistent with this idea, genome-wide approaches using whole exome sequencing, comparative sequence analysis of multiplex families to identify de novo mutations and global technologies to identify single nucleotide polymorphisms, copy number variants, dysregulation of the transcriptome and epigenetic variations have been conducted to obtain information about genetic alterations and potential predispositions possibly linked to the occurrence of a CHD phenotype. In the second part of this review we will summarize and discuss the available literature on identified genetic alterations linked to TOF and HLHS. PMID:26069455

76 FR 70709 - Sunshine Act Meeting; Emergency Meeting Notice

Science.gov (United States)

2011-11-15

... COMMODITY FUTURES TRADING COMMISSION Sunshine Act Meeting; Emergency Meeting Notice This notice that an emergency meeting was held is published pursuant to the provisions of the Government in the Sunshine Act, Public Law 94-409, 5 U.S.C. 552b. AGENCY HOLDING THE MEETING: Commodity Futures Trading...

Plant breeding and genetics newsletter. No. 18, January 2007

International Nuclear Information System (INIS)

2007-01-01

The Plant Breeding and Genetics (PBG) Section of the Joint FAO/IAEA Programme (NAFA/AGE) currently implement six Research Coordination Meetings (RCMs) ranging from fundamental aspects of effects of mutagens on DNA sequence to the assessment of nutrient uptake from biofortified crops. Particular attention was given the CRP: 'Identification and pyramiding of mutated genes: Novel approaches for improving crop tolerance to salinity and drought'. Highlight of training and other activities were also included

Genetic parameters of Visual Image Analysis primal cut carcass traits of commercial prime beef slaughter animals.

Science.gov (United States)

Moore, K L; Mrode, R; Coffey, M P

2017-10-01

Visual Image analysis (VIA) of carcass traits provides the opportunity to estimate carcass primal cut yields on large numbers of slaughter animals. This allows carcases to be better differentiated and farmers to be paid based on the primal cut yields. It also creates more accurate genetic selection due to high volumes of data which enables breeders to breed cattle that better meet the abattoir specifications and market requirements. In order to implement genetic evaluations for VIA primal cut yields, genetic parameters must first be estimated and that was the aim of this study. Slaughter records from the UK prime slaughter population for VIA carcass traits was available from two processing plants. After edits, there were 17 765 VIA carcass records for six primal cut traits, carcass weight as well as the EUROP conformation and fat class grades. Heritability estimates after traits were adjusted for age ranged from 0.32 (0.03) for EUROP fat to 0.46 (0.03) for VIA Topside primal cut yield. Adjusting the VIA primal cut yields for carcass weight reduced the heritability estimates, with estimates of primal cut yields ranging from 0.23 (0.03) for Fillet to 0.29 (0.03) for Knuckle. Genetic correlations between VIA primal cut yields adjusted for carcass weight were very strong, ranging from 0.40 (0.06) between Fillet and Striploin to 0.92 (0.02) between Topside and Silverside. EUROP conformation was also positively correlated with the VIA primal cuts with genetic correlation estimates ranging from 0.59 to 0.84, whereas EUROP fat was estimated to have moderate negative correlations with primal cut yields, estimates ranged from -0.11 to -0.46. Based on these genetic parameter estimates, genetic evaluation of VIA primal cut yields can be undertaken to allow the UK beef industry to select carcases that better meet abattoir specification and market requirements.

Enabling complex genetic circuits to respond to extrinsic environmental signals.

Science.gov (United States)

Hoynes-O'Connor, Allison; Shopera, Tatenda; Hinman, Kristina; Creamer, John Philip; Moon, Tae Seok

2017-07-01

Genetic circuits have the potential to improve a broad range of metabolic engineering processes and address a variety of medical and environmental challenges. However, in order to engineer genetic circuits that can meet the needs of these real-world applications, genetic sensors that respond to relevant extrinsic and intrinsic signals must be implemented in complex genetic circuits. In this work, we construct the first AND and NAND gates that respond to temperature and pH, two signals that have relevance in a variety of real-world applications. A previously identified pH-responsive promoter and a temperature-responsive promoter were extracted from the E. coli genome, characterized, and modified to suit the needs of the genetic circuits. These promoters were combined with components of the type III secretion system in Salmonella typhimurium and used to construct a set of AND gates with up to 23-fold change. Next, an antisense RNA was integrated into the circuit architecture to invert the logic of the AND gate and generate a set of NAND gates with up to 1168-fold change. These circuits provide the first demonstration of complex pH- and temperature-responsive genetic circuits, and lay the groundwork for the use of similar circuits in real-world applications. Biotechnol. Bioeng. 2017;114: 1626-1631. © 2017 Wiley Periodicals, Inc. © 2017 Wiley Periodicals, Inc.

Development of a Streamlined Work Flow for Handling Patients' Genetic Testing Insurance Authorizations.

Science.gov (United States)

Uhlmann, Wendy R; Schwalm, Katie; Raymond, Victoria M

2017-08-01

Obtaining genetic testing insurance authorizations for patients is a complex, time-involved process often requiring genetic counselor (GC) and physician involvement. In an effort to mitigate this complexity and meet the increasing number of genetic testing insurance authorization requests, GCs formed a novel partnership with an industrial engineer (IE) and a patient services associate (PSA) to develop a streamlined work flow. Eight genetics clinics and five specialty clinics at the University of Michigan were surveyed to obtain benchmarking data. Tasks needed for genetic testing insurance authorization were outlined and time-saving work flow changes were introduced including 1) creation of an Excel password-protected shared database between GCs and PSAs, used for initiating insurance authorization requests, tracking and follow-up 2) instituting the PSAs sending GCs a pre-clinic email noting each patients' genetic testing insurance coverage 3) inclusion of test medical necessity documentation in the clinic visit summary note instead of writing a separate insurance letter and 4) PSAs development of a manual with insurance providers and genetic testing laboratories information. These work flow changes made it more efficient to request and track genetic testing insurance authorizations for patients, enhanced GCs and PSAs communication, and reduced tasks done by clinicians.

Research and Applications of Shop Scheduling Based on Genetic Algorithms

Directory of Open Access Journals (Sweden)

Hang ZHAO

Full Text Available ABSTRACT Shop Scheduling is an important factor affecting the efficiency of production, efficient scheduling method and a research and application for optimization technology play an important role for manufacturing enterprises to improve production efficiency, reduce production costs and many other aspects. Existing studies have shown that improved genetic algorithm has solved the limitations that existed in the genetic algorithm, the objective function is able to meet customers' needs for shop scheduling, and the future research should focus on the combination of genetic algorithm with other optimized algorithms. In this paper, in order to overcome the shortcomings of early convergence of genetic algorithm and resolve local minimization problem in search process,aiming at mixed flow shop scheduling problem, an improved cyclic search genetic algorithm is put forward, and chromosome coding method and corresponding operation are given.The operation has the nature of inheriting the optimal individual ofthe previous generation and is able to avoid the emergence of local minimum, and cyclic and crossover operation and mutation operation can enhance the diversity of the population and then quickly get the optimal individual, and the effectiveness of the algorithm is validated. Experimental results show that the improved algorithm can well avoid the emergency of local minimum and is rapid in convergence.

Report of the 5th European expert meeting on rotavirus vaccination (EEROVAC).

Science.gov (United States)

de Hoog, Marieke L A; Vesikari, Timo; Giaquinto, Carlo; Huppertz, Hans-Iko; Martinon-Torres, Federico; Bruijning-Verhagen, Patricia

2018-04-03

The Fifth European Expert Meeting on Rotavirus Vaccination was convened in Utrecht, The Netherlands, in March 2017. The 2-day meeting included invited lectures as well as original oral and poster presentations and brought together experts from 21 countries. Summary findings of the meeting include: Rotavirus vaccination programmes in Europe have resulted in reductions of 60-90% in rotavirus outpatient visits and hospitalizations. Long term trends indicate this impact is sustained over the years. Herd effects, protecting unvaccinated children and neonates too young to be vaccinated have been observed in many European countries. Early evidence now also suggests that rotavirus vaccination may be instrumental in the prevention of celiac disease. Special attention should be given to preterm infants, who may age out of the vaccination window before hospital discharge and to HIV infected children who are at increased risk of severe rotavirus AGE. There is a small but increased risk of IS following rotavirus vaccination and parents should therefore be informed about possible signs and symptoms of IS. New insights in rotavirus genetic susceptibility and interactions with microbiome may open opportunities for interventions to improve protection by vaccination, in particular in LMIC. The development of several novel rotavirus vaccines discussed at the meeting is also promising in this respect.

Remedial action programs annual meeting: Meeting notes

International Nuclear Information System (INIS)

1987-01-01

The US Department of Energy Grand Junction Projects Office was pleased to host the 1987 Remedial Action programs Annual Meeting and herein presents notes from that meeting as prepared (on relatively short notice) by participants. These notes are a summary of the information derived from the workshops, case studies, and ad hoc committee reports rather than formal proceedings. The order of the materials in this report follows the actual sequence of presentations during the annual meeting

Genetic drift. The real tiger mother: from the clinical geneticist's perspective.

Science.gov (United States)

Shur, Natasha

2011-09-01

The Battle Hymn of the Tiger Mother by Amy Chua raises questions about motherhood and what is admirable. Chua promotes strict, Old World, uncompromising values stressing academic performance above all, insisting on drilling and practice, and instilling respect for authority. As clinical geneticists, we meet an entirely different type of mother than Chua, the clinical genetics mother who fights illnesses, schools, hospital policies, and insurance companies. She battles not against her child but for her child. With brilliance and resilience, she creates a child-centered world. The stories of four clinical genetics mothers rally us to reject extreme parenting and appreciate the simple joys of childhood. Copyright © 2011 Wiley-Liss, Inc.

76 FR 59454 - Sunshine Act Meeting; Notice of Public Meeting

Science.gov (United States)

2011-09-26

... RAILROAD RETIREMENT BOARD Sunshine Act Meeting; Notice of Public Meeting Notice is hereby given that the Railroad Retirement Board will hold a meeting on October 6, 2011, 10 a.m. at the Board's meeting room on the 8th floor of its headquarters building, 844 North Rush Street, Chicago, Illinois...

Influence of race/ethnicity on genetic counseling and testing for hereditary breast and ovarian cancer.

Science.gov (United States)

Forman, Andrea D; Hall, Michael J

2009-01-01

Risk assessment coupled with genetic counseling and testing for the cancer predisposition genes BRCA1 and BRCA2 (BRCA1/2) has become an integral element of comprehensive patient evaluation and cancer risk management in the United States for individuals meeting high-risk criteria for hereditary breast and ovarian cancer (HBOC). For mutation carriers, several options for risk modification have achieved substantial reductions in future cancer risk. However, several recent studies have shown lower rates of BRCA1/2 counseling and testing among minority populations. Here, we explore the role of race/ethnicity in cancer risk assessment, genetic counseling and genetic testing for HBOC and the BRCA1/2 cancer predisposition genes. Barriers to genetic services related to race/ethnicity and underserved populations, including socioeconomic barriers (e.g., time, access, geographic, language/cultural, awareness, cost) and psychosocial barriers (e.g., medical mistrust, perceived disadvantages to genetic services), as well as additional barriers to care once mutation carriers are identified, will be reviewed.

Terminology and classification of muscle injuries in sport: The Munich consensus statement

Science.gov (United States)

Mueller-Wohlfahrt, Hans-Wilhelm; Haensel, Lutz; Mithoefer, Kai; Ekstrand, Jan; English, Bryan; McNally, Steven; Orchard, John; van Dijk, C Niek; Kerkhoffs, Gino M; Schamasch, Patrick; Blottner, Dieter; Swaerd, Leif; Goedhart, Edwin; Ueblacker, Peter

2013-01-01

Objective To provide a clear terminology and classification of muscle injuries in order to facilitate effective communication among medical practitioners and development of systematic treatment strategies. Methods Thirty native English-speaking scientists and team doctors of national and first division professional sports teams were asked to complete a questionnaire on muscle injuries to evaluate the currently used terminology of athletic muscle injury. In addition, a consensus meeting of international sports medicine experts was established to develop practical and scientific definitions of muscle injuries as well as a new and comprehensive classification system. Results The response rate of the survey was 63%. The responses confirmed the marked variability in the use of the terminology relating to muscle injury, with the most obvious inconsistencies for the term strain. In the consensus meeting, practical and systematic terms were defined and established. In addition, a new comprehensive classification system was developed, which differentiates between four types: functional muscle disorders (type 1: overexertion-related and type 2: neuromuscular muscle disorders) describing disorders without macroscopic evidence of fibre tear and structural muscle injuries (type 3: partial tears and type 4: (sub)total tears/tendinous avulsions) with macroscopic evidence of fibre tear, that is, structural damage. Subclassifications are presented for each type. Conclusions A consistent English terminology as well as a comprehensive classification system for athletic muscle injuries which is proven in the daily practice are presented. This will help to improve clarity of communication for diagnostic and therapeutic purposes and can serve as the basis for future comparative studies to address the continued lack of systematic information on muscle injuries in the literature. What are the new things Consensus definitions of the terminology which is used in the field of muscle injuries

Toxicity and elemental composition of particulate matter from outdoor and indoor air of elementary schools in Munich, Germany.

Science.gov (United States)

Oeder, S; Dietrich, S; Weichenmeier, I; Schober, W; Pusch, G; Jörres, R A; Schierl, R; Nowak, D; Fromme, H; Behrendt, H; Buters, J T M

2012-04-01

Outdoor particulate matter (PM(10)) is associated with detrimental health effects. However, individual PM(10) exposure occurs mostly indoors. We therefore compared the toxic effects of classroom, outdoor, and residential PM(10). Indoor and outdoor PM(10) was collected from six schools in Munich during teaching hours and in six homes. Particles were analyzed by scanning electron microscopy and X-ray spectroscopy (EDX). Toxicity was evaluated in human primary keratinocytes, lung epithelial cells and after metabolic activation by several human cytochromes P450. We found that PM(10) concentrations during teaching hours were 5.6-times higher than outdoors (117 ± 48 μg/m(3) vs. 21 ± 15 μg/m(3), P particle number), organic (29%, probably originating from human skin), and Ca-carbonate particles (12%, probably originating from paper). Outdoor PM contained more Ca-sulfate particles (38%). Indoor PM at 6 μg/cm(2) (10 μg/ml) caused toxicity in keratinocytes and in cells expressing CYP2B6 and CYP3A4. Toxicity by CYP2B6 was abolished with the reactive oxygen species scavenger N-acetylcysteine. We concluded that outdoor PM(10) and indoor PM(10) from homes were devoid of toxicity. Indoor PM(10) was elevated, chemically different and toxicologically more active than outdoor PM(10). Whether the effects translate into a significant health risk needs to be determined. Until then, we suggest better ventilation as a sensible option. Indoor air PM(10) on an equal weight base is toxicologically more active than outdoor PM(10). In addition, indoor PM(10) concentrations are about six times higher than outdoor air. Thus, ventilation of classrooms with outdoor air will improve air quality and is likely to provide a health benefit. It is also easier than cleaning PM(10) from indoor air, which has proven to be tedious. © 2011 John Wiley & Sons A/S.

75 FR 59292 - Meeting of the Advisory Committee; Meeting

Science.gov (United States)

2010-09-27

... inclusion on future Joint Board examinations in actuarial mathematics, pension law and methodology referred... closed meeting of the Advisory Committee on Actuarial Examinations. DATES: The meeting will be held on... INFORMATION: Notice is hereby given that the Advisory Committee on Actuarial Examinations will meet at...

An Airborne Conflict Resolution Approach Using a Genetic Algorithm

Science.gov (United States)

Mondoloni, Stephane; Conway, Sheila

2001-01-01

An airborne conflict resolution approach is presented that is capable of providing flight plans forecast to be conflict-free with both area and traffic hazards. This approach is capable of meeting constraints on the flight plan such as required times of arrival (RTA) at a fix. The conflict resolution algorithm is based upon a genetic algorithm, and can thus seek conflict-free flight plans meeting broader flight planning objectives such as minimum time, fuel or total cost. The method has been applied to conflicts occurring 6 to 25 minutes in the future in climb, cruise and descent phases of flight. The conflict resolution approach separates the detection, trajectory generation and flight rules function from the resolution algorithm. The method is capable of supporting pilot-constructed resolutions, cooperative and non-cooperative maneuvers, and also providing conflict resolution on trajectories forecast by an onboard FMC.

Detailed genetic structure of European bitterling populations in Central Europe

Directory of Open Access Journals (Sweden)

Veronika Bartáková

2015-11-01

Full Text Available The European bitterling (Rhodeus amarus is a small cyprinid fish whose populations declined markedly between 1950 and 1980. However, its range currently expands, partly due to human-assisted introductions. We determined the genetic variability and detailed spatial structure among bitterling populations in Central Europe and tested alternative hypotheses about colonization of this area. Twelve polymorphic microsatellite loci on a large sample of 688 individuals had been used to analyse genetic variability and population structure. Samples originated from 27 localities with emphasis on area of the Czech Republic where three major sea drainages (Black, Baltic, and Northern Sea meet. Highly variable level of intrapopulation genetic variability had generally been detected and a recent decrease in numbers (“bottleneck” had been indicated by genetic data among six populations. High level of interpopulation differentiation was identified even within the basins. There was a significant role of genetic drift and indications of low dispersal ability of R. amarus. Surprisingly, the Odra River was inhabited by two distinct populations without any genetic signatures of a secondary contact. Czech part of the Odra (Baltic basin was colonized from the Danubian refugium (similarly to adjacent Danubian basin rivers including the Morava, while Polish part of the Odra was genetically similar to the populations in the Vistula River (Baltic basin, that has been colonized by a different (Eastern phylogeographic lineage of R. amarus. Most Czech R. amarus populations were colonized from the Danubian refugium, suggesting potential for a human-mediated colonization of the Odra or Elbe Rivers by R. amarus. One Elbe basin population was genetically mixed from the two (Danubian and Eastern phylogeographic lineages. In general the Czech populations of R. amarus were genetically stable except for a single population which has probably been recently introduced. This research

Genetic algorithms for protein threading.

Science.gov (United States)

Yadgari, J; Amir, A; Unger, R

1998-01-01

Despite many years of efforts, a direct prediction of protein structure from sequence is still not possible. As a result, in the last few years researchers have started to address the "inverse folding problem": Identifying and aligning a sequence to the fold with which it is most compatible, a process known as "threading". In two meetings in which protein folding predictions were objectively evaluated, it became clear that threading as a concept promises a real breakthrough, but that much improvement is still needed in the technique itself. Threading is a NP-hard problem, and thus no general polynomial solution can be expected. Still a practical approach with demonstrated ability to find optimal solutions in many cases, and acceptable solutions in other cases, is needed. We applied the technique of Genetic Algorithms in order to significantly improve the ability of threading algorithms to find the optimal alignment of a sequence to a structure, i.e. the alignment with the minimum free energy. A major progress reported here is the design of a representation of the threading alignment as a string of fixed length. With this representation validation of alignments and genetic operators are effectively implemented. Appropriate data structure and parameters have been selected. It is shown that Genetic Algorithm threading is effective and is able to find the optimal alignment in a few test cases. Furthermore, the described algorithm is shown to perform well even without pre-definition of core elements. Existing threading methods are dependent on such constraints to make their calculations feasible. But the concept of core elements is inherently arbitrary and should be avoided if possible. While a rigorous proof is hard to submit yet an, we present indications that indeed Genetic Algorithm threading is capable of finding consistently good solutions of full alignments in search spaces of size up to 10(70).

Recommendations from a meeting on health implications of genetically modified organism (GMO).

Science.gov (United States)

Amofah, George

2014-06-01

The Ghana Public Health Association organized a scientific seminar to examine the introduction of genetically modified organisms into public use and the health consequences. The seminar was driven by current public debate on the subject. The seminar identified some of the advantages of GMOs and also the health concerns. It is clear that there is the need to enhance local capacity to research the introduction and use of GMOs; to put in place appropriate regulatory mechanisms including particularly the labeling of GMO products and post-marketing surveillance for possible negative health consequences in the long term. Furthermore the appropriate state agency should put in place advocacy strategies to keep the public informed about GMOs.

76 FR 17967 - Meeting of the Advisory Committee; Meeting

Science.gov (United States)

2011-03-31

... Joint Board examinations in actuarial mathematics, pension law and methodology referred to in 29 U.S.C... closed meeting of the Advisory Committee on Actuarial Examinations. DATES: The meeting will be held on... INFORMATION: Notice is hereby given that the Advisory Committee on Actuarial Examinations will meet at Mercer...

77 FR 19034 - Meeting of the Advisory Committee; Meeting

Science.gov (United States)

2012-03-29

... Joint Board examinations in actuarial mathematics, pension law and methodology referred to in 29 U.S.C... closed meeting of the Advisory Committee on Actuarial Examinations. DATES: The meeting will be held on... INFORMATION: Notice is hereby given that the Advisory Committee on Actuarial Examinations will meet at...

77 FR 59979 - Meeting of the Advisory Committee; Meeting

Science.gov (United States)

2012-10-01

... actuarial mathematics, pension law and methodology referred to in 29 U.S.C. 1242(a)(1)(B). A determination... closed meeting of the Advisory Committee on Actuarial Examinations. DATES: The meeting will be held on... is hereby given that the Advisory Committee on Actuarial Examinations will meet at Towers Watson, 800...

The Anorexia Nervosa Genetics Initiative: Study description and sample characteristics of the Australian and New Zealand arm.

Science.gov (United States)

Kirk, Katherine M; Martin, Felicity C; Mao, Amy; Parker, Richard; Maguire, Sarah; Thornton, Laura M; Zhu, Gu; McAloney, Kerrie; Freeman, Jeremy L; Hay, Phillipa; Madden, Sloane; Morgan, Christine; Russell, Janice; Sawyer, Susan M; Hughes, Elizabeth K; Fairweather-Schmidt, A Kate; Fursland, Anthea; McCormack, Julie; Wagg, Fiona; Jordan, Jennifer; Kennedy, Martin A; Ward, Warren; Wade, Tracey D; Bulik, Cynthia M; Martin, Nicholas G

2017-06-01

Anorexia nervosa is a severe psychiatric disorder with high mortality rates. While its aetiology is poorly understood, there is evidence of a significant genetic component. The Anorexia Nervosa Genetics Initiative is an international collaboration which aims to understand the genetic basis of the disorder. This paper describes the recruitment and characteristics of the Australasian Anorexia Nervosa Genetics Initiative sample, the largest sample of individuals with anorexia nervosa ever assembled across Australia and New Zealand. Participants completed an online questionnaire based on the Structured Clinical Interview Diagnostic and Statistical Manual of Mental Disorders (4th ed.; DSM-IV) eating disorders section. Participants who met specified case criteria for lifetime anorexia nervosa were requested to provide a DNA sample for genetic analysis. Overall, the study recruited 3414 Australians and 543 New Zealanders meeting the lifetime anorexia nervosa case criteria by using a variety of conventional and social media recruitment methods. At the time of questionnaire completion, 28% had a body mass index ⩽ 18.5 kg/m 2 . Fasting and exercise were the most commonly employed methods of weight control, and were associated with the youngest reported ages of onset. At the time of the study, 32% of participants meeting lifetime anorexia nervosa case criteria were under the care of a medical practitioner; those with current body mass index anorexia nervosa in Australia and New Zealand to date. The proportion of people with anorexia nervosa currently receiving medical care, and the most common sources of treatment accessed, indicates the importance of training for general practitioners and dietitians in treating anorexia nervosa.

Planning and conducting meetings effectively, part I: planning a meeting.

Science.gov (United States)

Harolds, Jay

2011-12-01

Meetings are held by leaders for many purposes, including conveying information, raising morale, asking for opinions, brain storming, making people part of the problem-solving process, building trust, getting to a consensus, and making decisions. However, many meetings waste time, some undermine the leader's power, and some decrease morale. Part I of this series of articles gives some tips on basic planning for decision-making meetings. Part II of this series of articles analyzes selected components of decision-making meetings. Part III of this series will be on how the chairperson keeps decision-making meetings on track to make them efficient and productive.

Online and Off-line Visualization of Meeting Information and Meeting Support

NARCIS (Netherlands)

Nijholt, Antinus; Rienks, R.J.; Zwiers, Jakob; Reidsma, Dennis

2006-01-01

In current meeting research we see modest attempts to visualize the information that has been obtained by either capturing and probably more importantly by interpreting the activities that take place during a meeting. The meetings being considered take place in smart meeting rooms. Cameras,

Online and Off-line Visualization of Meeting Information and Meeting Support

NARCIS (Netherlands)

Nijholt, Antinus; Seah, H.S.; Rienks, R.J.; Zwiers, Jakob; Reidsma, Dennis

2006-01-01

In current meeting research we see modest attempts to visualize the information that has been obtained by either capturing and, probably more importantly, by interpreting the activities that take place during a meeting. The meetings being considered take place in smart meeting rooms. Cameras,

The Role of Vegetation in Mitigating Urban Land Surface Temperatures: A Case Study of Munich, Germany during the Warm Season

Directory of Open Access Journals (Sweden)

Sadroddin Alavipanah

2015-04-01

Full Text Available The Urban Heat Island (UHI is the phenomenon of altered increased temperatures in urban areas compared to their rural surroundings. UHIs grow and intensify under extreme hot periods, such as during heat waves, which can affect human health and also increase the demand for energy for cooling. This study applies remote sensing and land use/land cover (LULC data to assess the cooling effect of varying urban vegetation cover, especially during extreme warm periods, in the city of Munich, Germany. To compute the relationship between Land Surface Temperature (LST and Land Use Land Cover (LULC, MODIS eight-day interval LST data for the months of June, July and August from 2002 to 2012 and the Corine Land Cover (CLC database were used. Due to similarities in the behavior of surface temperature of different CLCs, some classes were reclassified and combined to form two major, rather simplified, homogenized classes: one of built-up area and one of urban vegetation. The homogenized map was merged with the MODIS eight-day interval LST data to compute the relationship between them. The results revealed that (i the cooling effect accrued from urban vegetation tended to be non-linear; and (ii a remarkable and stronger cooling effect in terms of LST was identified in regions where the proportion of vegetation cover was between seventy and almost eighty percent per square kilometer. The results also demonstrated that LST within urban vegetation was affected by the temperature of the surrounding built-up and that during the well-known European 2003 heat wave, suburb areas were cooler from the core of the urbanized region. This study concluded that the optimum green space for obtaining the lowest temperature is a non-linear trend. This could support urban planning strategies to facilitate appropriate applications to mitigate heat-stress in urban area.

The Doktabörse – an innovative online platform for research projects at the medical faculty of the LMU Munich

Directory of Open Access Journals (Sweden)

Nicolai, Leo

2017-08-01

Full Text Available Introduction: One of the most important extracurricular aspects of medical studies in Germany is a research thesis completed by most students. This research project often times conveys relevant competencies for the physician’s role as scientist. Nevertheless, the choice of the right project remains a challenge. Reasons for this are among others, missing structures for a comprehensive overview of research groups and their respective projects.Description of the project: We developed the online platform as an online marketplace for doctoral research projects. The platform enables authorized researchers to create working groups and upload, deactivate and change research projects within their institute. For interested students, a front end with integrated search function displays these projects in a structured and well-arranged way. In parallel, the provides for a comprehensive overview of research at the medical faculty. We evaluated Researchers‘ and students‘ use of the platform. Results: 96,6% of students participating in the evaluation (n=400 were in favor of a centralized research platform at the medical faculty. The platform grew at a steady pace and included 120 research groups in June 2016. The students appreciated the structure and design of the Two thirds of all uploaded projects matched successfully with doctoral students via the platform and over 94% of researchers stated that they did not need technical assistance with uploading projects and handling the platform. Discussion: The represents an innovative and well accepted platform for doctoral research projects. The platform is perceived positively by researchers and students alike. However, students criticized limited extent and timeliness of offered projects.In addition, the platform serves as databank of research at the medical faculty of the LMU Munich. The future potential of this platform is to provide for an integrated management solution of doctoral thesis projects

Genetic modification and genetic determinism

Science.gov (United States)

Resnik, David B; Vorhaus, Daniel B

2006-01-01

In this article we examine four objections to the genetic modification of human beings: the freedom argument, the giftedness argument, the authenticity argument, and the uniqueness argument. We then demonstrate that each of these arguments against genetic modification assumes a strong version of genetic determinism. Since these strong deterministic assumptions are false, the arguments against genetic modification, which assume and depend upon these assumptions, are therefore unsound. Serious discussion of the morality of genetic modification, and the development of sound science policy, should be driven by arguments that address the actual consequences of genetic modification for individuals and society, not by ones propped up by false or misleading biological assumptions. PMID:16800884

Genetic modification and genetic determinism

Directory of Open Access Journals (Sweden)

Vorhaus Daniel B

2006-06-01

Full Text Available Abstract In this article we examine four objections to the genetic modification of human beings: the freedom argument, the giftedness argument, the authenticity argument, and the uniqueness argument. We then demonstrate that each of these arguments against genetic modification assumes a strong version of genetic determinism. Since these strong deterministic assumptions are false, the arguments against genetic modification, which assume and depend upon these assumptions, are therefore unsound. Serious discussion of the morality of genetic modification, and the development of sound science policy, should be driven by arguments that address the actual consequences of genetic modification for individuals and society, not by ones propped up by false or misleading biological assumptions.

The New Face of Genetics: Creating A Multimedia Educational Tool for the Twenty-First Century

Science.gov (United States)

Fan, Audrey

In the study of certain genetic conditions, it is important to understand the specific "dysmorphology" associated with them. This describes the unique anatomical manifestations of the genetic condition. Traditionally, students learn about dysmorphology by reading text descriptions or looking at photographs of affected individuals. The New Face of Genetics is a film project that aims to teach students dysmorphology by featuring people who have specific genetic conditions. The goal is to enhance students' understanding of these conditions as well as to impart the humanity and beauty of the people who appear in the film. Students will have the opportunity to see dysmorphic features on the animated human form as well as meet individuals who are living with genetic difference. The target audience includes genetic counseling students and other medical professionals. Three short films were made in this format to demonstrate how this type of educational tool can be made. The featured conditions were Marfan syndrome, Sturge-Weber syndrome and Joubert syndrome. Future work will be carried out by other genetic counseling students who will make additional films based on our templates. A compendium of approximately 20 films will be eventually completed and released to genetic counseling programs and medical schools.

[Report on the 34th meeting of the German Clinical Immunology Workgroup, Frankfurt, 03.-04.11.2006].

Science.gov (United States)

Aries, P M; Witte, T; Lamprecht, P

2007-02-01

The annual meeting of the Clinical Immunology Workgroup focused on autoimmune vasculitides. The role of innate immunity, T- and B-cells, and innovative therapies for autoimmune vasculitides was discussed. Further topics of the meeting were the role of endothelial microparticles, ghrelin and leptin, regulatory and effector-memory T-cells in ANCA-associated vasculitides, as well as the lethal midline granuloma, intracytoplasmic cytokine-profile in Behcet's disease, autoantibodies in rheumatoid arthritis, polyarteritis nodosa with cranial manifestation, ILT6 as genetic marker in multiple sclerosis and Sjögren's syndrome, alpha-fodrin autoantibodies in multiple sclerosis, interferon-g autoantibodies in a patient with atypical mycobacteriosis, and autoreactive T-cells in murine lupus.

Against Genetic Tests for Athletic Talent: The Primacy of the Phenotype.

Science.gov (United States)

Loland, Sigmund

2015-09-01

New insights into the genetics of sport performance lead to new areas of application. One area is the use of genetic tests to identify athletic talent. Athletic performances involve a high number of complex phenotypical traits. Based on the ACCE model (review of Analytic and Clinical validity, Clinical utility, and Ethical, legal and social implications), a critique is offered of the lack of validity and predictive power of genetic tests for talent. Based on the ideal of children's right to an open future, a moral argument is given against such tests on children and young athletes. A possible role of genetic tests in sport is proposed in terms of identifying predisposition for injury. In meeting ACCE requirements, such tests could improve individualised injury prevention and increase athlete health. More generally, limitations of science are discussed in the identification of talent and in the understanding of complex human performance phenotypes. An alternative approach to talent identification is proposed in terms of ethically sensitive, systematic and evidence-based holistic observation over time of relevant phenotypical traits by experienced observers. Talent identification in sport should be based on the primacy of the phenotype.

When population genetics meets biological control of the invasive swallow-worts (Vincetoxicum nigrum (L.) Moench and V. rossicum (Kleopow) Barbar)

Science.gov (United States)

We explored the population genetics of two European swallow-worts belonging to the Apocynaceae that have become established in the eastern United States and Canada. Population genetic data concerning both native and introduced populations are being used to pinpoint introduced population origin, and ...

Public and biobank participant attitudes toward genetic research participation and data sharing.

Science.gov (United States)

Lemke, A A; Wolf, W A; Hebert-Beirne, J; Smith, M E

2010-01-01

Research assessing attitudes toward consent processes for high-throughput genomic-wide technologies and widespread sharing of data is limited. In order to develop a better understanding of stakeholder views toward these issues, this cross-sectional study assessed public and biorepository participant attitudes toward research participation and sharing of genetic research data. Forty-nine individuals participated in 6 focus groups; 28 in 3 public focus groups and 21 in 3 NUgene biorepository participant focus groups. In the public focus groups, 75% of participants were women, 75% had some college education or more, 46% were African-American and 29% were Hispanic. In the NUgene focus groups, 67% of participants were women, 95% had some college education or more, and the majority (76%) of participants was Caucasian. Five major themes were identified in the focus group data: (a) a wide spectrum of understanding of genetic research; (b) pros and cons of participation in genetic research; (c) influence of credibility and trust of the research institution; (d) concerns about sharing genetic research data and need for transparency in the Policy for Sharing of Data in National Institutes of Health-Supported or Conducted Genome-Wide Association Studies; (e) a need for more information and education about genetic research. In order to increase public understanding and address potential concerns about genetic research, future efforts should be aimed at involving the public in genetic research policy development and in identifying or developing appropriate educational strategies to meet the public's needs.

New and emerging technologies for genetic toxicity testing.

Science.gov (United States)

Lynch, Anthony M; Sasaki, Jennifer C; Elespuru, Rosalie; Jacobson-Kram, David; Thybaud, Véronique; De Boeck, Marlies; Aardema, Marilyn J; Aubrecht, Jiri; Benz, R Daniel; Dertinger, Stephen D; Douglas, George R; White, Paul A; Escobar, Patricia A; Fornace, Albert; Honma, Masamitsu; Naven, Russell T; Rusling, James F; Schiestl, Robert H; Walmsley, Richard M; Yamamura, Eiji; van Benthem, Jan; Kim, James H

2011-04-01

The International Life Sciences Institute (ILSI) Health and Environmental Sciences Institute (HESI) Project Committee on the Relevance and Follow-up of Positive Results in In Vitro Genetic Toxicity (IVGT) Testing established an Emerging Technologies and New Strategies Workgroup to review the current State of the Art in genetic toxicology testing. The aim of the workgroup was to identify promising technologies that will improve genotoxicity testing and assessment of in vivo hazard and risk, and that have the potential to help meet the objectives of the IVGT. As part of this initiative, HESI convened a workshop in Washington, DC in May 2008 to discuss mature, maturing, and emerging technologies in genetic toxicology. This article collates the abstracts of the New and Emerging Technologies Workshop together with some additional technologies subsequently considered by the workgroup. Each abstract (available in the online version of the article) includes a section addressed specifically to the strengths, weaknesses, opportunities, and threats associated with the respective technology. Importantly, an overview of the technologies and an indication of how their use might be aligned with the objectives of IVGT are presented. In particular, consideration was given with regard to follow-up testing of positive results in the standard IVGT tests (i.e., Salmonella Ames test, chromosome aberration assay, and mouse lymphoma assay) to add weight of evidence and/or provide mechanism of action for improved genetic toxicity risk assessments in humans. Copyright © 2010 Wiley-Liss, Inc.

Meetings as a positive boost? How and when meeting satisfaction impacts employee empowerment

NARCIS (Netherlands)

Allen, J.A.; Lehmann-Willenbrock, N.K.; Sands, S.

2016-01-01

Meetings constitute an important context for understanding organizational behavior and employee attitudes. Employees spend ever-increasing time in meetings and often complain about their meetings. In contrast, we explore the positive side of meetings and argue that satisfying meetings can empower

Cancer genetics education in a low- to middle-income country: evaluation of an interactive workshop for clinicians in Kenya.

Directory of Open Access Journals (Sweden)

Jessica A Hill

Full Text Available Clinical genetic testing is becoming an integral part of medical care for inherited disorders. While genetic testing and counseling are readily available in high-income countries, in low- and middle-income countries like Kenya genetic testing is limited and genetic counseling is virtually non-existent. Genetic testing is likely to become widespread in Kenya within the next decade, yet there has not been a concomitant increase in genetic counseling resources. To address this gap, we designed an interactive workshop for clinicians in Kenya focused on the genetics of the childhood eye cancer retinoblastoma. The objectives were to increase retinoblastoma genetics knowledge, build genetic counseling skills and increase confidence in those skills.The workshop was conducted at the 2013 Kenyan National Retinoblastoma Strategy meeting. It included a retinoblastoma genetics presentation, small group discussion of case studies and genetic counseling role-play. Knowledge was assessed by standardized test, and genetic counseling skills and confidence by questionnaire.Knowledge increased significantly post-workshop, driven by increased knowledge of retinoblastoma causative genetics. One-year post-workshop, participant knowledge had returned to baseline, indicating that knowledge retention requires more frequent reinforcement. Participants reported feeling more confident discussing genetics with patients, and had integrated more genetic counseling into patient interactions.A comprehensive retinoblastoma genetics workshop can increase the knowledge and skills necessary for effective retinoblastoma genetic counseling.

Cancer genetics education in a low- to middle-income country: evaluation of an interactive workshop for clinicians in Kenya.

Science.gov (United States)

Hill, Jessica A; Lee, Su Yeon; Njambi, Lucy; Corson, Timothy W; Dimaras, Helen

2015-01-01

Clinical genetic testing is becoming an integral part of medical care for inherited disorders. While genetic testing and counseling are readily available in high-income countries, in low- and middle-income countries like Kenya genetic testing is limited and genetic counseling is virtually non-existent. Genetic testing is likely to become widespread in Kenya within the next decade, yet there has not been a concomitant increase in genetic counseling resources. To address this gap, we designed an interactive workshop for clinicians in Kenya focused on the genetics of the childhood eye cancer retinoblastoma. The objectives were to increase retinoblastoma genetics knowledge, build genetic counseling skills and increase confidence in those skills. The workshop was conducted at the 2013 Kenyan National Retinoblastoma Strategy meeting. It included a retinoblastoma genetics presentation, small group discussion of case studies and genetic counseling role-play. Knowledge was assessed by standardized test, and genetic counseling skills and confidence by questionnaire. Knowledge increased significantly post-workshop, driven by increased knowledge of retinoblastoma causative genetics. One-year post-workshop, participant knowledge had returned to baseline, indicating that knowledge retention requires more frequent reinforcement. Participants reported feeling more confident discussing genetics with patients, and had integrated more genetic counseling into patient interactions. A comprehensive retinoblastoma genetics workshop can increase the knowledge and skills necessary for effective retinoblastoma genetic counseling.

Genome-wide association study (GWAS) for molar-incisor hypomineralization (MIH).

Science.gov (United States)

Kühnisch, Jan; Thiering, Elisabeth; Heitmüller, Daniela; Tiesler, Carla M T; Grallert, Harald; Heinrich-Weltzien, Roswitha; Hickel, Reinhard; Heinrich, Joachim

2014-01-01

This genome-wide association study (GWAS) investigated the relationship between molar-incisor hypomineralization (MIH) and possible genetic loci. Clinical and genetic data from the 10-year follow-up of 668 children from the Munich GINI-plus and LISA-plus birth cohort studies were analyzed. The dental examinations included the diagnosis of MIH according to the criteria of the European Academy of Paediatric Dentistry (EAPD). Children with MIH were categorized as those with a minimum of one hypomineralized first permanent molar. A GWAS was implemented following a quality-control step and an additive genetic effect was assumed. A total of 2,013,491 single-nucleotide polymorphisms (SNPs) were available for analysis. Rs13058467, which is located near the SCUBE1 gene on chromosome 22 (p MIH when using a threshold of p value MIH.

A Genetic Animal Model of Alcoholism for Screening Medications to Treat Addiction

Science.gov (United States)

Bell, Richard L.; Hauser, Sheketha; Rodd, Zachary A.; Liang, Tiebing; Sari, Youssef; McClintick, Jeanette; Rahman, Shafiqur; Engleman, Eric A.

2016-01-01

The purpose of this review is to present up-to-date pharmacological, genetic and behavioral findings from the alcohol-preferring P rat and summarize similar past work. Behaviorally, the focus will be on how the P rat meets criteria put forth for a valid animal model of alcoholism with a highlight on its use as an animal model of polysubstance abuse, including alcohol, nicotine and psychostimulants. Pharmacologically and genetically, the focus will be on the neurotransmitter and neuropeptide systems that have received the most attention: cholinergic, dopaminergic, GABAergic, glutamatergic, serotonergic, noradrenergic, corticotrophin releasing hormone, opioid, and neuropeptide Y. Herein we sought to place the P rat’s behavioral and neurochemical phenotypes, and to some extent its genotype, in the context of the clinical literature. After reviewing the findings thus far, this paper discusses future directions for expanding the use of this genetic animal model of alcoholism to identify molecular targets for treating drug addiction in general. PMID:27055615

Enhancing genetic gain in the era of molecular breeding.

Science.gov (United States)

Xu, Yunbi; Li, Ping; Zou, Cheng; Lu, Yanli; Xie, Chuanxiao; Zhang, Xuecai; Prasanna, Boddupalli M; Olsen, Michael S

2017-05-17

As one of the important concepts in conventional quantitative genetics and breeding, genetic gain can be defined as the amount of increase in performance that is achieved annually through artificial selection. To develop pro ducts that meet the increasing demand of mankind, especially for food and feed, in addition to various industrial uses, breeders are challenged to enhance the potential of genetic gain continuously, at ever higher rates, while they close the gaps that remain between the yield potential in breeders' demonstration trials and the actual yield in farmers' fields. Factors affecting genetic gain include genetic variation available in breeding materials, heritability for traits of interest, selection intensity, and the time required to complete a breeding cycle. Genetic gain can be improved through enhancing the potential and closing the gaps, which has been evolving and complemented with modern breeding techniques and platforms, mainly driven by molecular and genomic tools, combined with improved agronomic practice. Several key strategies are reviewed in this article. Favorable genetic variation can be unlocked and created through molecular and genomic approaches including mutation, gene mapping and discovery, and transgene and genome editing. Estimation of heritability can be improved by refining field experiments through well-controlled and precisely assayed environmental factors or envirotyping, particularly for understanding and controlling spatial heterogeneity at the field level. Selection intensity can be significantly heightened through improvements in the scale and precision of genotyping and phenotyping. The breeding cycle time can be shortened by accelerating breeding procedures through integrated breeding approaches such as marker-assisted selection and doubled haploid development. All the strategies can be integrated with other widely used conventional approaches in breeding programs to enhance genetic gain. More transdisciplinary

“AquaTrace” The development of tools for tracing and evaluating the genetic impact of fish from aquaculture

DEFF Research Database (Denmark)

Eg Nielsen, Einar; Bekkevold, Dorte; Svåsand, Terje

2012-01-01

Aquaculture represents a key solution to meet the escalating demand for fish. Accordingly, development of appropriate legislation within the European Union aquaculture sector underpinned by cutting‐edge research and technology is required. This necessitates implementation of breeding programmes...... to identify of the genetic origin of both wild and farmed fish (assignment and genetic traceability), as well as for the detection of interbreeding genetic introgression between farmed and wild stocks. This work will be carried out on three marine fish of economic significance: the European sea bass...... (Dicentrarchus labrax), gilthead sea bream (Sparus aurata), and turbot (Scophthalmus maximus). To address quantitative effects of farm introgression, the rationale is to examine links between key fitness and life‐history traits and specific functional genetic variation between wild and farmed fish, using...

EMBO workshop al fin del mundo: a meeting on membrane trafficking and its implication for polarity and diseases.

Science.gov (United States)

Marzolo, María-Paz; Faundez, Victor; Galli, Thierry

2015-07-01

The EMBO worskhop at the "end of the world'" (al fin del mundo), a meeting on membrane trafficking and its implication for polarity and diseases, took place in the Chilean Patagonia surrounded by the landscapes once witnessed by Charles Darwin. The meeting showcased some of the best membrane trafficking science with an emphasis in neuroscience and disease models. Speakers from Europe, USA, South America and the graduate students behind it; embarked on an enthusiastic and eclectic dialog where a wide range of cell types, model genetic systems, and diseases where discussed. This meeting demonstrated the power of trafficking concepts to integrate diverse biology and to formulate mechanisms of normal and disease cells. © 2015 Société Française des Microscopies and Société de Biologie Cellulaire de France. Published by John Wiley & Sons Ltd.

75 FR 42125 - Notice of Public Meeting, Dakotas Resource Advisory Council Meeting

Science.gov (United States)

2010-07-20

... Public Meeting, Dakotas Resource Advisory Council Meeting AGENCY: Bureau of Land Management, Interior..., Bureau of Land Management (BLM) Dakotas Resource Advisory Council (RAC) will meet as indicated below. DATES: The next regular meeting of the Dakotas Resource Advisory Council will be held on September 2...

Report of the First Community Consultation on the Responsible Collection and Use of Samples for Genetic Research, September 25-26, 2000

Energy Technology Data Exchange (ETDEWEB)

Greenberg, Judith H.

2002-05-22

The First Community Consultation on the Responsible Collection and Use of Samples for Genetic Research was held in Bethesda, Maryland, on September 25-26, 2000. The consultation was convened by the National Institute of General Medical Sciences (NIGMS) of the National Institutes of Health (NIH). Approximately 120 individuals participated in the consultation, half from a broad range of communities and populations, and half from government. The participants shared their views and concerns about population- and community-based genetic research, expanding the focus of the meeting from the collection and use of blood or other tissue samples for genetic research to broader issues and concerns about the conduct of genetic research in general with populations and communities.

Meetings in Academe: It's Time for an "EXTREME MEETING MAKEOVER!"

Science.gov (United States)

Berk, Ronald A.

2012-01-01

Meetings have a bad reputation with faculty. Rarely does one hear a positive word uttered about an upcoming or past meeting. That reputation has metastasized throughout higher education. The primary reason is because meetings can be major time wasters, accomplishing very little, often deteriorating into just another social event, or they may be…

76 FR 21779 - Notice of Public Meeting, Dakotas Resource Advisory Council Meeting

Science.gov (United States)

2011-04-18

... Public Meeting, Dakotas Resource Advisory Council Meeting AGENCY: Bureau of Land Management, Interior..., Bureau of Land Management (BLM) Dakotas Resource Advisory Council (RAC), will meet as indicated below. DATES: The next regular meeting of the Dakotas Resource Advisory Council will be held on May 11, 2011 in...

75 FR 15724 - Notice of Public Meeting, Dakotas Resource Advisory Council Meeting

Science.gov (United States)

2010-03-30

... Public Meeting, Dakotas Resource Advisory Council Meeting AGENCY: Bureau of Land Management, Interior..., Bureau of Land Management (BLM) Dakotas Resource Advisory Council (RAC) will meet as indicated below. DATES: The next regular meeting of the Dakotas Resource Advisory Council will be held on May 6, 2010, in...

76 FR 43705 - Notice of Public Meeting, Dakotas Resource Advisory Council Meeting

Science.gov (United States)

2011-07-21

... Public Meeting, Dakotas Resource Advisory Council Meeting AGENCY: Bureau of Land Management, Interior... Interior, Bureau of Land Management (BLM) Dakotas Resource Advisory Council (RAC), will meet as indicated below. DATES: The next regular meeting of the Dakotas Resource Advisory Council will be held on Aug. 17...

A Genetic Algorithm for Feeding Trajectory Optimisation of Fed-batch Fermentation Processes

Directory of Open Access Journals (Sweden)

Stoyan Tzonkov

2009-03-01

Full Text Available In this work a genetic algorithm is proposed with the purpose of the feeding trajectory optimization during a fed-batch fermentation of E. coli. The feed rate profiles are evaluated based on a number of objective functions. Optimization results obtained for different feeding trajectories demonstrate that the genetic algorithm works well and shows good computational performance. Developed optimal feed profiles meet the defined criteria. The ration of the substrate concentration and the difference between actual cell concentration and theoretical maximum cell concentration is defined as the most appropriate objective function. In this case the final cell concentration of 43 g·l-1 and final product concentration of 125 g·l-1 are achieved and there is not significant excess of substrate.

77 FR 22800 - Notice of Public Meeting, Dakotas Resource Advisory Council Meeting

Science.gov (United States)

2012-04-17

... Public Meeting, Dakotas Resource Advisory Council Meeting AGENCY: Bureau of Land Management, Interior..., Bureau of Land Management (BLM) Dakotas Resource Advisory Council (RAC) will meet as indicated below. DATES: The next regular meeting of the Dakotas RAC will be held on May 9, 2012, in Spearfish, SD. The...

Dismay with GM maize: A science-based solution to public resistance against genetically modified crops that could be compatible with organic farming

OpenAIRE

Ryffel, Gerhart U

2011-01-01

New discoveries often raise new problems or meet with public resistance. Rather than giving up on technologies such as genetically modified organisms, we should use science to develop them further and make them safer.

STAFF MEETING

CERN Document Server

2003-01-01

I should like to invite all members of the CERN Personnel to a meeting on Wednesday 25th June 2003 at 11.00 hrs - Auditorium, bldg. 500 to give a report on the outcome of the June Meetings of Council and its Committees. Closed-circuit transmission of the meeting will be available in the AB Auditorium (Prévessin), the AB Auditorium (Meyrin - bldg. 6), the IT Auditorium (bldg. 31) and the AT Auditorium (bldg. 30). Luciano Maiani Director General

Was passiert vor dem Meeting? Small Talk steigert die Meetingeffektivität [What happens before meetings? Small talk promotes meeting effectiveness

NARCIS (Netherlands)

Allen, J.A.; Lehmann-Willenbrock, N.K.

2013-01-01

Research interest: We explore how pre-meeting small talk impacts meeting effectiveness through the” ripple effect”, allowing before meeting communication/behaviors to ripple into and impact the scheduled meeting. Method: Data was obtained using an online survey of working adults (N = 252). A new

Genetic classes and genetic categories : Protecting genetic groups through data protection law

NARCIS (Netherlands)

Hallinan, Dara; de Hert, Paul; Taylor, L.; Floridi, L.; van der Sloot, B.

2017-01-01

Each person shares genetic code with others. Thus, one individual’s genome can reveal information about other individuals. When multiple individuals share aspects of genetic architecture, they form a ‘genetic group’. From a social and legal perspective, two types of genetic group exist: Those which

An Adaptive Test Sheet Generation Mechanism Using Genetic Algorithm

Directory of Open Access Journals (Sweden)

Huan-Yu Lin

2012-01-01

Full Text Available For test-sheet composition systems, it is important to adaptively compose test sheets with diverse conceptual scopes, discrimination and difficulty degrees to meet various assessment requirements during real learning situations. Computation time and item exposure rate also influence performance and item bank security. Therefore, this study proposes an Adaptive Test Sheet Generation (ATSG mechanism, where a Candidate Item Selection Strategy adaptively determines candidate test items and conceptual granularities according to desired conceptual scopes, and an Aggregate Objective Function applies Genetic Algorithm (GA to figure out the approximate solution of mixed integer programming problem for the test-sheet composition. Experimental results show that the ATSG mechanism can efficiently, precisely generate test sheets to meet the various assessment requirements than existing ones. Furthermore, according to experimental finding, Fractal Time Series approach can be applied to analyze the self-similarity characteristics of GA’s fitness scores for improving the quality of the test-sheet composition in the near future.

Plant Genetic Resources: Selected Issues from Genetic Erosion to Genetic Engineering

Directory of Open Access Journals (Sweden)

Karl Hammer

2008-04-01

Full Text Available Plant Genetic Resources (PGR continue to play an important role in the development of agriculture. The following aspects receive a special consideration:1. Definition. The term was coined in 1970. The genepool concept served as an important tool in the further development. Different approaches are discussed.2. Values of Genetic Resources. A short introduction is highlighting this problem and stressing the economic usfulness of PGR.3. Genetic Erosion. Already observed by E. Baur in 1914, this is now a key issue within PGR. The case studies cited include Ethiopia, Italy, China, S Korea, Greece and S. Africa. Modern approaches concentrate on allelic changes in varieties over time but neglect the landraces. The causes and consequences of genetic erosion are discussed.4. Genetic Resources Conservation. Because of genetic erosion there is a need for conservation. PGR should be consigned to the appropriate method of conservation (ex situ, in situ, on-farm according to the scientific basis of biodiversity (genetic diversity, species diversity, ecosystem diversity and the evolutionary status of plants (cultivated plants, weeds, related wild plants (crop wild relatives.5. GMO. The impact of genetically engineered plants on genetic diversity is discussed.6. The Conclusions and Recommendations stress the importance of PGR. Their conservation and use are urgent necessities for the present development and future survival of mankind.

Bioinformatics tools and database resources for systems genetics analysis in mice-a short review and an evaluation of future needs

NARCIS (Netherlands)

Durrant, Caroline; Swertz, Morris A.; Alberts, Rudi; Arends, Danny; Moeller, Steffen; Mott, Richard; Prins, Pjotr; van der Velde, K. Joeri; Jansen, Ritsert C.; Schughart, Klaus

During a meeting of the SYSGENET working group 'Bioinformatics', currently available software tools and databases for systems genetics in mice were reviewed and the needs for future developments discussed. The group evaluated interoperability and performed initial feasibility studies. To aid future

MeetingVis: Visual Narratives to Assist in Recalling Meeting Context and Content.

Science.gov (United States)

Shi, Yang; Bryan, Chris; Bhamidipati, Sridatt; Zhao, Ying; Zhang, Yaoxue; Ma, Kwan-Liu

2018-06-01

In team-based workplaces, reviewing and reflecting on the content from a previously held meeting can lead to better planning and preparation. However, ineffective meeting summaries can impair this process, especially when participants have difficulty remembering what was said and what its context was. To assist with this process, we introduce MeetingVis, a visual narrative-based approach to meeting summarization. MeetingVis is composed of two primary components: (1) a data pipeline that processes the spoken audio from a group discussion, and (2) a visual-based interface that efficiently displays the summarized content. To design MeetingVis, we create a taxonomy of relevant meeting data points, identifying salient elements to promote recall and reflection. These are mapped to an augmented storyline visualization, which combines the display of participant activities, topic evolutions, and task assignments. For evaluation, we conduct a qualitative user study with five groups. Feedback from the study indicates that MeetingVis effectively triggers the recall of subtle details from prior meetings: all study participants were able to remember new details, points, and tasks compared to an unaided, memory-only baseline. This visual-based approaches can also potentially enhance the productivity of both individuals and the whole team.

Commuting for meetings

DEFF Research Database (Denmark)

Fosgerau, Mogens; Engelson, Leonid; Franklin, Joel P.

2014-01-01

Urban congestion causes travel times to exhibit considerable variability, which leads to coordination problems when people have to meet. We analyze a game for the timing of a meeting between two players who must each complete a trip of random duration to reach the meeting, which does not begin...

The current and potential impact of genetics and genomics on neuropsychopharmacology.

Science.gov (United States)

Harrison, Paul J

2015-05-01

One justification for the major scientific and financial investments in genetic and genomic studies in medicine is their therapeutic potential, both for revealing novel targets for drugs which treat the disease process, as well as allowing for more effective and safe use of existing medications. This review considers the extent to which this promise has yet been realised within psychopharmacology, how things are likely to develop in the foreseeable future, and the key issues involved. It draws primarily on examples from schizophrenia and its treatments. One observation is that there is evidence for a range of genetic influences on different aspects of psychopharmacology in terms of discovery science, but far less evidence that meets the standards required before such discoveries impact upon clinical practice. One reason is that results reveal complex genetic influences that are hard to replicate and usually of very small effect. Similarly, the slow progress being made in revealing the genes that underlie the major psychiatric syndromes hampers attempts to apply the findings to identify novel drug targets. Nevertheless, there are some intriguing positive findings of various kinds, and clear potential for genetics and genomics to play an increasing and major role in psychiatric drug discovery. Copyright © 2013 Elsevier B.V. and ECNP. All rights reserved.

75 FR 21629 - HIT Policy Committee Advisory Meeting; Notice of Meeting

Science.gov (United States)

2010-04-26

... DEPARTMENT OF HEALTH AND HUMAN SERVICES Office of the National Coordinator for Health Information Technology HIT Policy Committee Advisory Meeting; Notice of Meeting AGENCY: Office of the National... Information Technology (ONC). The meeting will be open to the public. Name of Committee: HIT Policy Committee...

Novel and potential application of cryopreservation to plant genetic transformation.

Science.gov (United States)

Wang, Biao; Zhang, Zhibo; Yin, Zhenfang; Feng, Chaohong; Wang, Qiaochun

2012-01-01

The world population now is 6.7 billion and is predicted to reach 9 billion by 2050. Such a rapid growing population has tremendously increased the challenge for food security. Obviously, it is impossible for traditional agriculture to ensure the food security, while plant biotechnology offers considerable potential to realize this goal. Over the last 15 years, great benefits have been brought to sustainable agriculture by commercial cultivation of genetically modified (GM) crops. Further development of new GM crops will with no doubt contribute to meeting the requirements for food by the increasing population. The present article provides updated comprehensive information on novel and potential application of cryopreservation to genetic transformation. The major progresses that have been achieved in this subject include (1), long-term storage of a large number of valuable plant genes, which offers a good potential for further development of novel cultivars by genetic transformation; (2), retention of regenerative capacity of embryogenic tissues and protoplasts, which ensures efficient plant regeneration system for genetic transformation; (3), improvement of transformation efficiency and plant regeneration of transformed cells; (4), long-term preservation of transgenic materials with stable expression of transgenes and productive ability of recombinant proteins, which allows transgenic materials to be stored in a safe manner before being analyzed and evaluated, and allows establishment of stable seed stocks for commercial production of homologous proteins. Data provided in this article clearly demonstrate that cryo-technique has an important role to play in the whole chain of genetic transformation. Further studies coupling cryotechnique and genetic transformation are expected to significantly improve development of new GM crops. Copyright © 2011 Elsevier Inc. All rights reserved.

Genetic improvement of plants for enhanced bio-ethanol production.

Science.gov (United States)

Saha, Sanghamitra; Ramachandran, Srinivasan

2013-04-01

The present world energy situation urgently requires exploring and developing alternate, sustainable sources for fuel. Biofuels have proven to be an effective energy source but more needs to be produced to meet energy goals. Whereas first generation biofuels derived from mainly corn and sugarcane continue to be used and produced, the contentious debate between "feedstock versus foodstock" continues. The need for sources that can be grown under different environmental conditions has led to exploring newer sources. Lignocellulosic biomass is an attractive source for production of biofuel, but pretreatment costs to remove lignin are high and the process is time consuming. Genetically modified plants that have increased sugar or starch content, modified lignin content, or produce cellulose degrading enzymes are some options that are being explored and tested. This review focuses on current research on increasing production of biofuels by genetic engineering of plants to have desirable characteristics. Recent patents that have been filed in this area are also discussed.

Adults' perceptions of genetic counseling and genetic testing.

Science.gov (United States)

Houfek, Julia Fisco; Soltis-Vaughan, Brigette S; Atwood, Jan R; Reiser, Gwendolyn M; Schaefer, G Bradley

2015-02-01

This study described the perceptions of genetic counseling and testing of adults (N = 116) attending a genetic education program. Understanding perceptions of genetic counseling, including the importance of counseling topics, will contribute to patient-focused care as clinical genetic applications for common, complex disorders evolve. Participants completed a survey addressing: the importance of genetic counseling topics, benefits and negative effects of genetic testing, and sharing test results. Topics addressing practical information about genetic conditions were rated most important; topics involving conceptual genetic/genomic principles were rated least important. The most frequently identified benefit and negative effect of testing were prevention/early detection/treatment and psychological distress. Participants perceived that they were more likely to share test results with first-degree than other relatives. Findings suggest providing patients with practical information about genetic testing and genetic contributions to disease, while also determining whether their self-care abilities would be enhanced by teaching genetic/genomic principles. Copyright © 2014 Elsevier Inc. All rights reserved.

75 FR 5595 - HIT Standards Committee Advisory Meeting; Notice of Meeting

Science.gov (United States)

2010-02-03

... Technology HIT Standards Committee Advisory Meeting; Notice of Meeting AGENCY: Office of the National... Health Information Technology (ONC). The meeting will be open to the public. Name of Committee: HIT... Federal Health IT Strategic Plan, and in accordance with policies developed by the HIT Policy Committee...

75 FR 21628 - HIT Standards Committee Advisory Meeting; Notice of Meeting

Science.gov (United States)

2010-04-26

... Technology HIT Standards Committee Advisory Meeting; Notice of Meeting AGENCY: Office of the National... Information Technology (ONC). The meeting will be open to the public. Name of Committee: HIT Standards... Strategic Plan, and in accordance with policies developed by the HIT Policy Committee. Date and Time: The...

Meeting Mid-Year Meeting

Indian Academy of Sciences (India)

23 Newsletter of the Indian Academy of ScienCE. 57th Annual. Meeting ... Srinivas, Institute for Social and Economic. Change ... "Quantum mechanics and statistical mechanics of anyons" .... Special Issue on Geomagnetic Methods and.

Comparison study of genetic diversity between rice varieties from northeast China and Japan

International Nuclear Information System (INIS)

Li Hongyu; Wang Haize; Zhang Longhai; Liu Menghong; Xu Zhengjin; Zhao Minghui; Xu Hai; Wang Jiayu; Si Yang

2011-01-01

The genetic diversity of 18 rice varieties from northeast China and 13 rice varieties from Japan were investigated by 20 phenotypic traits and SSR assay with 40 pairs of primers. The results showed that 82 phenotypic variation and 108 alleles were detected. With an average of 2.54 alleles on every locus the phenotypic variation and alleles in northeast China were 72 and 103, respectively, and 63 and 94 were respectively with an average of 2.32 alleles on every locus in Japanese varieties. Genetic variation among different varieties varied greatly and among different groups varied slightly. Genetic diversity of varieties in northeast China was much higher than those in Japan, and 94.7% of the alleles from Japanese varieties were included in the varieties from northeast China. The available specific alleles were already very limited in the varieties from Japan and can not meet the rice breeding requirements for northeastern China. (authors)

Meetings in Organizations

DEFF Research Database (Denmark)

Ravn, Ib

as having to serve organizational stakeholders (such as customers and users), and work must be subjectively meaningful to the modern, well-educated employee. Do meetings answer to these challenges? A survey of 300 knowledge workers in five highly successful, knowledge-intensive corporations in Denmark...... showed that although employees were satisfied with their managers; traditional meeting-management skills, the customer was largely invisible in organizational meetings, and the hearts and minds of the employees were not engaged to any significant degree in meetings. It is concluded that despite massive...

Taking minutes of meetings

CERN Document Server

Gutmann, Joanna

2016-01-01

aking Minutes of Meetings guides you through the entire process behind minute taking: arranging the meeting; writing the agenda; creating the optimum environment; structuring the meeting and writing notes up accurately. The minute-taker is one of the most important and powerful people in a meeting and you can use this opportunity to develop your knowledge, broaden your horizons and build credibility within the organization. Taking Minutes of Meetings is an easy to read 'dip-in, dip-out' guide which shows you how to confidently arrange meetings and produce minutes. It provides hands-on advice about the sections of a meeting as well as tips on how to create an agenda, personal preparation, best practice advice on taking notes and how to improve your accuracy. Brand new chapters of this 4th edition include guidance on using technology to maximize effectiveness and practical help with taking minutes for a variety of different types of meetings. The creating success series of books... With over one million copi...

75 FR 39954 - Oversight of Laboratory Developed Tests; Public Meeting; Change of Meeting Location

Science.gov (United States)

2010-07-13

...] Oversight of Laboratory Developed Tests; Public Meeting; Change of Meeting Location AGENCY: Food and Drug... location for the upcoming public meeting entitled ``Oversight of Laboratory Developed Tests.'' A new... the public meeting, FDA is announcing in this notice a new location for the public meeting. II. New...

75 FR 42125 - Notice of Public Meeting, Eastern Montana Resource Advisory Council Meeting

Science.gov (United States)

2010-07-20

... Public Meeting, Eastern Montana Resource Advisory Council Meeting AGENCY: Bureau of Land Management... Interior, Bureau of Land Management (BLM) Eastern Montana Resource Advisory Council (RAC) will meet as indicated below. DATES: The next regular meeting of the Eastern Montana Resource Advisory Council will be...

75 FR 3489 - Notice of Public Meeting, Eastern Montana Resource Advisory Council Meeting

Science.gov (United States)

2010-01-21

... Public Meeting, Eastern Montana Resource Advisory Council Meeting AGENCY: Bureau of Land Management... Interior, Bureau of Land Management (BLM) Eastern Montana Resource Advisory Council (RAC), will meet as indicated below. DATES: The next regular meeting of the Eastern Montana Resource Advisory Council will be...

75 FR 47312 - Board Meeting; Sunshine Act Meetings

Science.gov (United States)

2010-08-05

... INTER-AMERICAN FOUNDATION Board Meeting; Sunshine Act Meetings Time and Date: August 9, 2010, 8:30 a.m.-5:30 p.m.. Place: 101 Constitution Avenue, Washington, DC 20001. Status: Closed session as provided in 22 CFR 1004.4(f). Matters to be Considered: Executive Session. Portions to be Closed to the...

Towards a genetic architecture of cryptic genetic variation

Indian Academy of Sciences (India)

Home; Journals; Journal of Genetics; Volume 84; Issue 3. Towards a genetic architecture of cryptic genetic variation and genetic assimilation: the contribution of K. G. Bateman. Ian Dworkin. Commentary on J. Genet. Classic Volume 84 Issue 3 December 2005 pp 223-226 ...

78 FR 22225 - Meeting: African Development Foundation, Board of Directors Executive Session Meeting

Science.gov (United States)

2013-04-15

...;and investigations, committee meetings, agency decisions and rulings, #0;delegations of authority... Executive Session Meeting Meeting: African Development Foundation, Board of Directors Executive Session Meeting Time: Tuesday, April 23, 2013 11:15 a.m. to 2:15 p.m. Place: 1400 Eye Street NW., Suite 1000...

77 FR 42507 - Notice of Public Meeting, Eastern Montana Resource Advisory Council Meeting

Science.gov (United States)

2012-07-19

... Public Meeting, Eastern Montana Resource Advisory Council Meeting AGENCY: Bureau of Land Management... Interior, Bureau of Land Management (BLM) Eastern Montana Resource Advisory Council (RAC) will meet as indicated below. DATES: The next regular meeting of the Eastern Montana RAC will be held on September 19...

77 FR 70807 - Notice of Public Meeting, Eastern Montana Resource Advisory Council Meeting

Science.gov (United States)

2012-11-27

... Public Meeting, Eastern Montana Resource Advisory Council Meeting AGENCY: Bureau of Land Management... Interior, Bureau of Land Management (BLM) Eastern Montana Resource Advisory Council (RAC) will meet as indicated below. DATES: The next regular meeting of the Eastern Montana RAC will be held on December 6, 2012...

77 FR 42760 - Notice of Public Meeting, Eastern Montana Resource Advisory Council Meeting

Science.gov (United States)

2012-07-20

... Public Meeting, Eastern Montana Resource Advisory Council Meeting AGENCY: Bureau of Land Management... Interior, Bureau of Land Management (BLM) Eastern Montana Resource Advisory Council (RAC) will meet as indicated below. DATES: The next regular meeting of the Eastern Montana RAC will be held on September 19...

MICRONEEDLE STRUCTURE DESIGN AND OPTIMIZATION USING GENETIC ALGORITHM

Directory of Open Access Journals (Sweden)

N. A. ISMAIL

2015-07-01

Full Text Available This paper presents a Genetic Algorithm (GA based microneedle design and analysis. GA is an evolutionary optimization technique that mimics the natural biological evolution. The design of microneedle structure considers the shape of microneedle, material used, size of the array, the base of microneedle, the lumen base, the height of microneedle, the height of the lumen, and the height of the drug container or reservoir. The GA is executed in conjunction with ANSYS simulation system to assess the design specifications. The GA uses three operators which are reproduction, crossover and mutation to manipulate the genetic composition of the population. In this research, the microneedle is designed to meet a number of significant specifications such as nodal displacement, strain energy, equivalent stress and flow rate of the fluid / drug that flow through its channel / lumen. A comparison study is conducted to investigate the design of microneedle structure with and without the implementation of GA model. The results showed that GA is able to optimize the design parameters of microneedle and is capable to achieve the required specifications with better performance.

Genetic privacy.

Science.gov (United States)

Sankar, Pamela

2003-01-01

During the past 10 years, the number of genetic tests performed more than tripled, and public concern about genetic privacy emerged. The majority of states and the U.S. government have passed regulations protecting genetic information. However, research has shown that concerns about genetic privacy are disproportionate to known instances of information misuse. Beliefs in genetic determinacy explain some of the heightened concern about genetic privacy. Discussion of the debate over genetic testing within families illustrates the most recent response to genetic privacy concerns.

Plant breeding and genetics newsletter. No. 20, January 2008

International Nuclear Information System (INIS)

2008-01-01

The highlight of this issue is the Second Coordinators Meeting under RAS/5/048 (ARASIA): 'Mutation Induction and Supportive Breeding and Biotechnologies for Improving Crop Productivity', on 11-15 November 2007, in Damascus, Syrian Arab Republic. A major achievement of this regional project was the adoption of the Standard Material Transfer Agreement (SMTA) for germplasm exchanges. It puts the ARASIA States Parties participating in this project into a leadership position for the regional application of the SMTA under the Multilateral System on Access and Benefit Sharing in the framework of the International Treaty on Plant Genetic Resources for Food and Agriculture

Plant breeding and genetics newsletter. No. 20, January 2008

Energy Technology Data Exchange (ETDEWEB)

NONE

2008-01-15

The highlight of this issue is the Second Coordinators Meeting under RAS/5/048 (ARASIA): 'Mutation Induction and Supportive Breeding and Biotechnologies for Improving Crop Productivity', on 11-15 November 2007, in Damascus, Syrian Arab Republic. A major achievement of this regional project was the adoption of the Standard Material Transfer Agreement (SMTA) for germplasm exchanges. It puts the ARASIA States Parties participating in this project into a leadership position for the regional application of the SMTA under the Multilateral System on Access and Benefit Sharing in the framework of the International Treaty on Plant Genetic Resources for Food and Agriculture.

ACCU MEETING

CERN Multimedia

Chris Onions

2002-01-01

DRAFT Agenda for the meeting to be held on Wednesday 4 December 2002 At 9:15 a.m. in room 60-6-002 Chairman's remarks Adoption of the agenda Minutes of the previous meeting Matters arising News from the CERN Management Fellows, Associates and Summer Student Programmes Particle Data Book distribution Revoking Computer accounts Equipment insurance on site Reports from ACCU representatives on other committees Users' Office news Any Other Business Dates for meetings in 2003 Agenda for the next meeting Anyone wishing to raise any points under item 12 is invited to send them to the Chairman in writing or by e-mail to Christopher.Onions@cern.ch   ACCU is the forum for discussion between the CERN Management and the representatives of CERN Users to review the practical means taken by CERN for the work of Users of the Laboratory. The User Representatives to ACCU are (CERN internal telephone numbers in brackets): Austria W. Adam (71661) Belgium G. Wilquet (74664) Bulgaria R. Tzenov (74837...

ACCU Meeting

CERN Multimedia

PH Department

2011-01-01

DRAFT Agenda for the meeting to be held on Wednesday 15 June 2011 At 9:15 a.m. in room 60-6-002 Chairperson’s remarks Adoption of the agenda Minutes of the previous meeting Matters arising News from the CERN Management Report on services from GS department Update on Safety at CERN Reports from ACCU representatives on other Committees a. Scientific Information Policy Board (SIPB) b. IT Service Review Meeting (ITSRM) c. GS User Commission Users’ Office news Any Other Business Agenda for the next meeting Anyone wishing to raise any points under item 10 is invited to send them to the Chairperson in writing or by e-mail to Michael.Hauschild@cern.ch Michael Hauschild (Secretary) ACCU is the forum for discussion between the CERN Management and the representatives of CERN Users to review the practical means taken by CERN for the work of Users of the Laboratory. The User Representatives to ACCU are (CERN internal telephone numbers in bra...

Archaea: Evolution, Physiology, and Molecular Biology

DEFF Research Database (Denmark)

field, including an account by Carl Woese of his original discovery of the Archaea (until 1990 termed archaebacteria) and the initially mixed reactions of the scientific community. The review chapters and specialized articles address the emerging significance of the Archaea within a broader scientific......Introduced by Crafoord Prize winner Carl Woese, this volume combines reviews of the major developments in archaeal research over the past 10-15 years with more specialized articles dealing with important recent breakthroughs. Drawing on major themes presented at the June 2005 meeting held in Munich...

EDITORIAL: Nano Meets Spectroscopy Nano Meets Spectroscopy

Science.gov (United States)

Birch, David J. S.

2012-08-01

The multidisciplinary two-day Nano Meets Spectroscopy (NMS) event was held at the National Physical Laboratory (NPL), Teddington, UK, in September 2011. The event was planned from the outset to be at the interface of several areas—in particular, spectroscopy and nanoscience, and to bring together topics and people with different approaches to achieving common goals in biomolecular science. Hence the meeting cut across traditional boundaries and brought together researchers using diverse techniques, particularly fluorescence and Raman spectroscopy. Despite engaging common problems, these techniques are frequently seen as mutually exclusive with the two communities rarely interacting at conferences. The meeting was widely seen to have lived up to its billing in good measure. It attracted the maximum capacity of ~120 participants, including 22 distinguished speakers (9 from outside the UK), over 50 posters and a vibrant corporate exhibition comprising 10 leading instrument companies and IOP Publishing. The organizers were Professor David Birch (Chair), Dr Karen Faulds and Professor Duncan Graham of the University of Strathclyde, Professor Cait MacPhee of the University of Edinburgh and Dr Alex Knight of NPL. The event was sponsored by the European Science Foundation, the Institute of Physics, the Royal Society of Chemistry, NPL and the Scottish Universities Physics Alliance. The full programme and abstracts are available at http://sensor.phys.strath.ac.uk/nms/program.php. The programme was quite ambitious in terms of the breadth and depth of scope. The interdisciplinary and synergistic concept of 'X meets Y' played well, cross-fertilization between different fields often being a source of inspiration and progress. Fluorescence and Raman spectroscopy provided the core, but the meeting had little repetition and also attracted contributions on more specialist techniques such as CARS, super-resolution, single molecule and chiral methods. In terms of application the

75 FR 16510 - Meeting of the Advisory Committee; Meeting

Science.gov (United States)

2010-04-01

... recommended for inclusion on future Joint Board examinations in actuarial mathematics, pension law and... closed meeting of the Advisory Committee on Actuarial Examinations. DATES: The meeting will be held on.... SUPPLEMENTARY INFORMATION: Notice is hereby given that the Advisory Committee on Actuarial Examinations will...

78 FR 19008 - Meeting of the Advisory Committee; Meeting

Science.gov (United States)

2013-03-28

... inclusion on future Joint Board examinations in actuarial mathematics, pension law and methodology referred... closed meeting of the Advisory Committee on Actuarial Examinations. DATES: The meeting will be held on.... SUPPLEMENTARY INFORMATION: Notice is hereby given that the Advisory Committee on Actuarial Examinations will...

Forensic Science in Support of Wildlife Conservation Efforts - Genetic Approaches (Global Trends).

Science.gov (United States)

Linacre, A

2011-01-01

Wildlife forensic science is a relatively recent development to meet the increasing need of the criminal justice system where there are investigations in alleged transgressions of either international or national legislation. This application of science draws on conservation genetics and forensic geneticists from mainstream forensic science. This review is a broad overview of the history of forensic wildlife science and some of the recent developments in forensic wildlife genetics with the application of DNA developments to nonhuman samples encountered in a forensic science investigation. The review will move from methods to look at the entire genome, when there is no previous knowledge of the species studied, through methods of species identification, using DNA to determine a possible geographic origin, through to assigning samples to a particular individual or a close genetic relative of this individual. The transfer of research methods into the criminal justice system for the investigation of wildlife crimes has been largely successful as is illustrated in the review. The review concludes with comments on the need for standardization and regulation in wildlife forensic science. Copyright © 2011 Central Police University.

Research and application of genetic algorithm in path planning of logistics distribution vehicle

Science.gov (United States)

Wang, Yong; Zhou, Heng; Wang, Ying

2017-08-01

The core of the logistics distribution system is the vehicle routing planning, research path planning problem, provide a better solution has become an important issue. In order to provide the decision support for logistics and distribution operations, this paper studies the problem of vehicle routing with capacity constraints (CVRP). By establishing a mathematical model, the genetic algorithm is used to plan the path of the logistics vehicle to meet the minimum logistics and transportation costs.

Bioinformatics tools and database resources for systems genetics analysis in miceça short review and an evaluation of future needs

NARCIS (Netherlands)

Durrant, M.C.; Swertz, M.A.; Alberts, R.; Arends, D.; Möller, S.; Mott, R.; Prins, J.C.P.; Velde, van der K.J.; Jansen, R.C.; Schughart, K.

2012-01-01

During a meeting of the SYSGENET working group ‘Bioinformatics’, currently available software tools and databases for systems genetics in mice were reviewed and the needs for future developments discussed. The group evaluated interoperability and performed initial feasibility studies. To aid future

77 FR 31894 - Sunshine Act Meeting Notice, Regular Board of Directors Meeting

Science.gov (United States)

2012-05-30

...,Washington, DC 20005. STATUS: Open. CONTACT PERSON FOR MORE INFORMATION: Erica Hall, Assistant Corporate... Meeting Minutes V. Approval of the Finance, Budget and Program Committee Meeting Minutes VI. Approval of the Corporate Administration Committee Meeting Minutes VII. Executive Session VIII. Board Elections...

E-Infrastructure Concertation Meeting

CERN Multimedia

Katarina Anthony

2010-01-01

The 8th e-Infrastructure Concertation Meeting was held in the Globe from 4 to 5 November to discuss the development of Europe’s distributed computing and storage resources.   Project leaders attend the E-Concertation Meeting at the Globe on 5 November 2010. © Corentin Chevalier E-Infrastructures have become an indispensable tool for scientific research, linking researchers to virtually unlimited e-resources like the grid. The recent e-Infrastructure Concertation Meeting brought together e-Science project leaders to discuss the development of this tool in the European context. The meeting was part of an ongoing initiative to develop a world-class e-infrastructure resource that would establish European leadership in e-Science. The e-Infrastructure Concertation Meeting was organised by the Commission Services (EC) with the support of e-ScienceTalk. “The Concertation meeting at CERN has been a great opportunity for e-ScienceTalk to meet many of the 38 new proje...

Clostridium XIV Meeting

Energy Technology Data Exchange (ETDEWEB)

Lynd, Lee

2016-08-28

The 14th biannual Clostridium meeting was held at Dartmouth College from August 28 through 31, 2016. As noted in the meeting program (http://clostridiumxiv.com/wp-content/uploads/2016/09/Clostridium_XIV_program.pdf). the meeting featured 119 registered attendees, 33 oral presentations, 5 of which were given by younger presenters, 40 posters, and 2 keynote presentations, with strong participation by female and international scientists.

77 FR 71828 - Meeting of the Advisory Committee; Meeting

Science.gov (United States)

2012-12-04

... recommended for inclusion on future Joint Board examinations in actuarial mathematics and methodology referred... meeting of the Advisory Committee on Actuarial Examinations (portions of which will be open to the public... Committee on Actuarial Examinations will meet at the Internal Revenue Service, 1111 Constitution Avenue NW...

75 FR 76486 - Meeting of the Advisory Committee; Meeting

Science.gov (United States)

2010-12-08

... that may be recommended for inclusion on future Joint Board examinations in actuarial mathematics and... meeting of the Advisory Committee on Actuarial Examinations (portions of which will be open to the public... the Advisory Committee on Actuarial Examinations will meet at the Internal Revenue Service, 1111...

What does it mean to be genomically literate?: National Human Genome Research Institute Meeting Report.

Science.gov (United States)

Hurle, Belen; Citrin, Toby; Jenkins, Jean F; Kaphingst, Kimberly A; Lamb, Neil; Roseman, Jo Ellen; Bonham, Vence L

2013-08-01

Genomic discoveries will increasingly advance the science of medicine. Limited genomic literacy may adversely impact the public's understanding and use of the power of genetics and genomics in health care and public health. In November 2011, a meeting was held by the National Human Genome Research Institute to examine the challenge of achieving genomic literacy for the general public, from kindergarten to grade 12 to adult education. The role of the media in disseminating scientific messages and in perpetuating or reducing misconceptions was also discussed. Workshop participants agreed that genomic literacy will be achieved only through active engagement between genomics experts and the varied constituencies that comprise the public. This report summarizes the background, content, and outcomes from this meeting, including recommendations for a research agenda to inform decisions about how to advance genomic literacy in our society.

75 FR 22168 - Region VI-Houston District; Advisory Council Meeting; Public Meeting

Science.gov (United States)

2010-04-27

... SMALL BUSINESS ADMINISTRATION Region VI--Houston District; Advisory Council Meeting; Public Meeting The Small Business Administration-Region VI--Houston Advisory Council, located in the geographical Area of Houston, Texas will hold a federal public meeting on--Thursday, May 20, 2010, starting at 10:30...

Hydrogen Contractors Meeting

Energy Technology Data Exchange (ETDEWEB)

Fitzsimmons, Tim [Dept. of Energy (DOE), Washington DC (United States). Office of Basic Energy Sciences. Division of Materials Sciences and Engineering

2006-05-16

This volume highlights the scientific content of the 2006 Hydrogen Contractors Meeting sponsored by the Division of Materials Sciences and Engineering (DMS&E) on behalf of the Office of Basic Energy Sciences (BES) of the U. S. Department of Energy (DOE). Hydrogen Contractors Meeting held from May 16-19, 2006 at the Crystal Gateway Marriott Hotel Arlington, Virginia. This meeting is the second in a series of research theme-based Contractors Meetings sponsored by DMS&E held in conjunction with our counterparts in the Office of Energy Efficiency and Renewable Energy (EERE) and the first with the Hydrogen, Fuel Cells and Infrastructure Technologies Program. The focus of this year’s meeting is BES funded fundamental research underpinning advancement of hydrogen storage. The major goals of these research efforts are the development of a fundamental scientific base in terms of new concepts, theories and computational tools; new characterization capabilities; and new materials that could be used or mimicked in advancing capabilities for hydrogen storage.

Where Times Meet

Directory of Open Access Journals (Sweden)

Theodore R. Schatzki

2005-01-01

Full Text Available This essay pursues two goals: (1 to argue that two fundamental types of time—the time of objective reality and “the time of the soul”—meet in human activity and history and (2 to defend the legitimacy of calling a particular version of the second type a kind of time. The essay begins by criticizing Paul Ricoeur’s version of the claim that times of these two sorts meet in history. It then presents an account of human activity based on Heidegger’s Being and Time, according to which certain times of the two types—existential temporality and succession—meet in human activity. The legitimacy of calling existential temporality a kind of time is then defended via an expanded analysis of activity that examines where the two times meet there. The concluding section briefly considers a conception of historical time due to David Carr before showing why history is a broader domain encompassing human activity where the two times meet.

75 FR 28062 - Meeting of the Advisory Committee; Meeting

Science.gov (United States)

2010-05-19

... questions which may be recommended for inclusion on future Joint Board examinations in actuarial mathematics... meeting of the Advisory Committee on Actuarial Examinations (a portion of which will be open to the public... the Advisory Committee on Actuarial Examinations will meet in at the Internal Revenue Service Building...

From Genetics to Genetic Algorithms

Indian Academy of Sciences (India)

Genetic algorithms (GAs) are computational optimisation schemes with an ... The algorithms solve optimisation problems ..... Genetic Algorithms in Search, Optimisation and Machine. Learning, Addison-Wesley Publishing Company, Inc. 1989.

Meeting report VLPNPV: Sessions 1 and 2: Plenary.

Science.gov (United States)

Sainsbury, Frank

2014-01-01

Following the highly successful inaugural meeting in 2012, the second installment of Virus-Like Particles and Nano-Particle Vaccines (VLPNPV), proved to be a worthy follow-up in an outstanding conference series. VLPNPV is a forum for academics and industry to address one of the major areas of need in biomedical sciences, the development of novel prophylactic and therapeutic vaccines. The conference was opened by Professor Marianne Manchester of the University of California, San Diego who pointed to the significance of the site chosen for the conference, the Salk Institute. Founded by Jonas Salk, the Salk Institute for Biological Studies is a non-profit, independent research institute with focuses in molecular biology and genetics, neurosciences, and plant biology. This diversity in research themes reflects the wishes of the institute's founder who saw value in using interdisciplinary approaches to understanding the basic principles in life, aimed at generating new therapies and treatments for human disease. Likewise, interdisciplinarity was reflected in the main themes of the meeting, which also highlight some of the potential advantages of virus-like particle (VLP) and nanoparticle vaccines, including novel formulations/adjuvanting effects, structurally accurate/designed antigens, production systems and capacity, and tailoring the immune response. These themes were covered by the 2 plenary sessions that opened the conference and are described in this report.

Evaluation of genetically altered medflies for use in sterile insect technique programmes. Proceedings of the final research co-ordination meeting

International Nuclear Information System (INIS)

1997-01-01

Although the medfly is a key pest in many areas of the world, there are important fruit growing areas where other fruit flies are key pests. It was concluded that it would be of value for any future CRP on genetic sexing to include these species. For the development of genetic sexing systems in these species much can be gained from the experiences with the medfly. However, at present, a similar procedure will have to be followed which will entail the construction of genetic maps, the development of cytological techniques and the induction of male linked translocation. In future, the availability of molecular methods could enable sexing systems to be transferred between species. The proceedings contain 11 papers, which range from an initial molecular analysis of the genome of the fly to a field experiment to assess the impact of an all-male release

75 FR 52303 - Notice of Meeting; Siskiyou Resource Advisory Committee Meeting at New Location

Science.gov (United States)

2010-08-25

... DEPARTMENT OF AGRICULTURE Forest Service Notice of Meeting; Siskiyou Resource Advisory Committee Meeting at New Location SUMMARY: The Siskiyou County Resource Advisory Committee (RAC) will hold its last two meetings in 2010 at a new location. DATES: The meetings will be held on September 20 and October...

Molecular Markers and Cotton Genetic Improvement: Current Status and Future Prospects

Directory of Open Access Journals (Sweden)

Waqas Malik

2014-01-01

Full Text Available Narrow genetic base and complex allotetraploid genome of cotton (Gossypium hirsutum L. is stimulating efforts to avail required polymorphism for marker based breeding. The availability of draft genome sequence of G. raimondii and G. arboreum and next generation sequencing (NGS technologies facilitated the development of high-throughput marker technologies in cotton. The concepts of genetic diversity, QTL mapping, and marker assisted selection (MAS are evolving into more efficient concepts of linkage disequilibrium, association mapping, and genomic selection, respectively. The objective of the current review is to analyze the pace of evolution in the molecular marker technologies in cotton during the last ten years into the following four areas: (i comparative analysis of low- and high-throughput marker technologies available in cotton, (ii genetic diversity in the available wild and improved gene pools of cotton, (iii identification of the genomic regions within cotton genome underlying economic traits, and (iv marker based selection methodologies. Moreover, the applications of marker technologies to enhance the breeding efficiency in cotton are also summarized. Aforementioned genomic technologies and the integration of several other omics resources are expected to enhance the cotton productivity and meet the global fiber quantity and quality demands.

GBD 2000 - Proceedings of the 4. annual meeting of 'Gesellschaft fuer Biologische Strahlenforschung'; GBS 2000 - Proceedings der 4. Jahrestagung der Gesellschaft fuer Biologische Strahlenforschung

Energy Technology Data Exchange (ETDEWEB)

Eckardt-Schupp, F.; Ahne, F.; Kistler, M. (eds.) [Gesellschaft fuer Strahlen- und Umweltforschung mbH Muenchen, Neuherberg (Germany). Inst. fuer Strahlenbiologie

2000-07-01

The headings of the meeting were as follows: Radiation chemistry and micro beam irradiation; DNA radiation damage and biological models; DNA repair; genetic radiation effects; radiation effects and stress effects on gene expression; cellular radiobiology; radiobiology of tumors and normal tissues; epidemiology.

ACCU MEETING

CERN Multimedia

Chris Onions (Secretary)

2001-01-01

DRAFT Agenda for the meeting to be held on Wednesday 5 December 2001 At 9:15 a.m. in room 60-6-002 1. Chairman's remarks 2. Adoption of the agenda 3. Minutes of the previous meeting 4. Matters arising 5. News from the CERN Management 6. Housing 7. Restaurant Surveillance Committee 8. Users' Office news 9. Election of ACCU chairman 10. Any Other Business 11. Dates for meetings in 2002 12. Agenda for the next meeting Anyone wishing to raise any points under item 10 is invited to send them to the Chairman in writing or by e-mail to Christopher.Onions@cern.ch ACCU is the forum for discussion between the CERN Management and the representatives of CERN Users to review the practical means taken by CERN for the work of Users of the Laboratory. The User Representatives to ACCU are (CERN internal telephone numbers in brackets): Austria  W. Adam  (71661) Belgium  G. Wilquet  (74664) Bulgaria  R. Tzenov  (77958) Czech Republic  P. Závada&am...

ACCU MEETING

CERN Multimedia

Chris Onions (Secretary)

2001-01-01

DRAFT Agenda for the meeting to be held on Wednesday 5 December 2001 At 9:15 a.m. in room 60-6-002 1. Chairman's remarks 2. Adoption of the agenda 3. Minutes of the previous meeting 4. Matters arising 5. News from the CERN Management 6. Housing 7. Restaurant Surveillance Committee 8. Users' Office news 9. Election of ACCU chairman 10. Any Other Business 11. Dates for meetings in 2002 12. Agenda for the next meetingAnyone wishing to raise any points under item 10 is invited to send them to the Chairman in writing or by e-mail to Christopher.Onions@cern.ch ACCU is the forum for discussion between the CERN Management and the representatives of CERN Users to review the practical means taken by CERN for the work of Users of the Laboratory. The User Representatives to ACCU are (CERN internal telephone numbers in brackets): Austria W. Adam (71661) Belgium G. Wilquet (74664) Bulgaria R. Tzenov (77958) Czech Republic P. Závada (75877) Denmark A. Waananen (75941) Finland A. Kiiskinen (79387) Fr...

ACCU MEETING

CERN Multimedia

2000-01-01

DRAFT Agenda for the meeting to be held on Wednesday 6 December 2000 At 10 a.m. in the 6th floor Conference Room, Main Building Chairman's remarks Adoption of the agenda News from the CERN Management Minutes of the previous meeting Matters arising Equal Opportunities at CERN The Summer Student programme CERN Programme for Physics High School Teachers Users' Office News Any Other Business Dates for Meetings in 2001 Agenda for the next meeting Anyone wishing to raise any points under item 10 is invited to send them to the Secretary in writing via the CERN Users' Office or by e-mail to Christopher.Onions@cern.ch Chris Onions (Secretary) ACCU is the forum for discussion between the CERN Management and the representatives of CERN Users to review the practical means taken by CERN for the work of Users of the Laboratory. The User Representatives to ACCU are (CERN internal telephone numbers in brackets) :   Austria G. Neuhofer (74094) Belgium G. Wilquet (74664) Bulgaria R. Tzenov (77958)...

ACCU MEETING

CERN Multimedia

Chris Onions (Secretary)

2000-01-01

DRAFT Agenda for the meeting to be held on Wednesday 6 December 2000 At 10 a.m. in the 6th floor Conference Room, Main Building Chairman's remarks Adoption of the agenda News from the CERN Management Minutes of the previous meeting Matters arising Equal Opportunities at CERN The Summer Student programme CERN Programme for Physics High School Teachers Users' Office News Any Other Business Dates for Meetings in 2001 Agenda for the next meeting Anyone wishing to raise any points under item 10 is invited to send them to the Secretary in writing via the CERN Users' Office or by e-mail to Christopher.Onions@cern.ch Chris Onions (Secretary) ACCU is the forum for discussion between the CERN Management and the representatives of CERN Users to review the practical means taken by CERN for the work of Users of the Laboratory. The User Representatives to ACCU are (CERN internal telephone numbers in brackets) : Austria G. Neuhofer (74094) Belgium G. Wilquet (74664) Bulgaria R. Tzenov (77958) Czech Re...

Monster potential meets potential monster: pros and cons of deploying genetically modified microalgae for biofuels production.

Science.gov (United States)

Flynn, K J; Mitra, A; Greenwell, H C; Sui, J

2013-02-06

Biofuels production from microalgae attracts much attention but remains an unproven technology. We explore routes to enhance production through modifications to a range of generic microalgal physiological characteristics. Our analysis shows that biofuels production may be enhanced ca fivefold through genetic modification (GM) of factors affecting growth rate, respiration, photoacclimation, photosynthesis efficiency and the minimum cell quotas for nitrogen and phosphorous (N : C and P : C). However, simulations indicate that the ideal GM microalgae for commercial deployment could, on escape to the environment, become a harmful algal bloom species par excellence, with attendant risks to ecosystems and livelihoods. In large measure, this is because an organism able to produce carbohydrate and/or lipid at high rates, providing stock metabolites for biofuels production, will also be able to attain a stoichiometric composition that will be far from optimal as food for the support of zooplankton growth. This composition could suppress or even halt the grazing activity that would otherwise control the microalgal growth in nature. In consequence, we recommend that the genetic manipulation of microalgae, with inherent consequences on a scale comparable to geoengineering, should be considered under strict international regulation.

About Genetic Counselors

Science.gov (United States)

... clinical care in many areas of medicine. Assisted Reproductive Technology/Infertility Genetics Cancer Genetics Cardiovascular Genetics Cystic Fibrosis Genetics Fetal Intervention and Therapy Genetics Hematology Genetics Metabolic Genetics ...

Communicating genetic risk information for common disorders in the era of genomic medicine.

Science.gov (United States)

Lautenbach, Denise M; Christensen, Kurt D; Sparks, Jeffrey A; Green, Robert C

2013-01-01

Communicating genetic risk information in ways that maximize understanding and promote health is increasingly important given the rapidly expanding availability and capabilities of genomic technologies. A well-developed literature on risk communication in general provides guidance for best practices, including presentation of information in multiple formats, attention to framing effects, use of graphics, sensitivity to the way numbers are presented, parsimony of information, attentiveness to emotions, and interactivity as part of the communication process. Challenges to communicating genetic risk information include deciding how best to tailor it, streamlining the process, deciding what information to disclose, accepting that communications may have limited influence, and understanding the impact of context. Meeting these challenges has great potential for empowering individuals to adopt healthier lifestyles and improve public health, but will require multidisciplinary approaches and collaboration.

June 1992 Hall B collaboation meeting

International Nuclear Information System (INIS)

Dennis, L.

1992-01-01

The Hall B collaboration meeting at the CEBAF 1992 Summer Workshop consisted of technical and physics working group meetings, a special beam line devices working group meeting the first meeting of the membership committee, a technical representatives meeting and a full collaboration meeting. Highlights of these meetings are presented in this report

Plant breeding and genetics newsletter. No. 9

Energy Technology Data Exchange (ETDEWEB)

NONE

2002-07-01

There have been a number of important events related to the activity of the Plant Breeding and Genetics sub-programme in the past six months. The joint FAO/IAEA RCMs on 'Molecular characterization of mutated genes controlling important traits for seed crop improvement' and 'Mutational analysis of root characters in annual food plants related to plant performance' were held in June, in Krakow, Poland. It was the third RCM of the CRP on crop plant genomics and the second in the CRP on root systems. More than 40 scientists from twenty countries participated in the meeting. Significant progress was achieved in presented projects of diverse areas of both CRPs. Although genomics and root genetics are methodologically among the most rapidly developing disciplines, the participants successfully tried to follow the latest developments. The Consultants Meeting on 'Physical mapping technologies for the identification and characterization of mutated genes contributing to crop quality' was also held in June, in Vienna. Physical mapping technologies provide new tools for the rapid advancement of breeding programs and are highly applicable to neglected crops in developing countries. Furthermore, they open new opportunities for developing modern approaches to plant improvement research. Consultants recommended the organization of a Co-ordinated Research Project dealing with application of these new technologies to breeding programmes with the use of induced mutations for crop improvement. It is expected that the new CRP will be initiated this year. In close collaboration with EU COST 851 'Gametic cells and molecular breeding for crop improvement' project we started with preparation and editing of a book on 'Doubled haploid production in crop plants. A manual'. More than 40 manuscripts were collected, reviewed by a team of EU COST 851 experts and are now in the final editing phase. Similarly, we finished editorial work on publishing the training material from the FAO/IAEA Training

Plant breeding and genetics newsletter. No. 9

International Nuclear Information System (INIS)

2002-07-01

There have been a number of important events related to the activity of the Plant Breeding and Genetics sub-programme in the past six months. The joint FAO/IAEA RCMs on 'Molecular characterization of mutated genes controlling important traits for seed crop improvement' and 'Mutational analysis of root characters in annual food plants related to plant performance' were held in June, in Krakow, Poland. It was the third RCM of the CRP on crop plant genomics and the second in the CRP on root systems. More than 40 scientists from twenty countries participated in the meeting. Significant progress was achieved in presented projects of diverse areas of both CRPs. Although genomics and root genetics are methodologically among the most rapidly developing disciplines, the participants successfully tried to follow the latest developments. The Consultants Meeting on 'Physical mapping technologies for the identification and characterization of mutated genes contributing to crop quality' was also held in June, in Vienna. Physical mapping technologies provide new tools for the rapid advancement of breeding programs and are highly applicable to neglected crops in developing countries. Furthermore, they open new opportunities for developing modern approaches to plant improvement research. Consultants recommended the organization of a Co-ordinated Research Project dealing with application of these new technologies to breeding programmes with the use of induced mutations for crop improvement. It is expected that the new CRP will be initiated this year. In close collaboration with EU COST 851 'Gametic cells and molecular breeding for crop improvement' project we started with preparation and editing of a book on 'Doubled haploid production in crop plants. A manual'. More than 40 manuscripts were collected, reviewed by a team of EU COST 851 experts and are now in the final editing phase. Similarly, we finished editorial work on publishing the training material from the FAO/IAEA Training

Genetic algorithm parameters tuning for resource-constrained project scheduling problem

Science.gov (United States)

Tian, Xingke; Yuan, Shengrui

2018-04-01

Project Scheduling Problem (RCPSP) is a kind of important scheduling problem. To achieve a certain optimal goal such as the shortest duration, the smallest cost, the resource balance and so on, it is required to arrange the start and finish of all tasks under the condition of satisfying project timing constraints and resource constraints. In theory, the problem belongs to the NP-hard problem, and the model is abundant. Many combinatorial optimization problems are special cases of RCPSP, such as job shop scheduling, flow shop scheduling and so on. At present, the genetic algorithm (GA) has been used to deal with the classical RCPSP problem and achieved remarkable results. Vast scholars have also studied the improved genetic algorithm for the RCPSP problem, which makes it to solve the RCPSP problem more efficiently and accurately. However, for the selection of the main parameters of the genetic algorithm, there is no parameter optimization in these studies. Generally, we used the empirical method, but it cannot ensure to meet the optimal parameters. In this paper, the problem was carried out, which is the blind selection of parameters in the process of solving the RCPSP problem. We made sampling analysis, the establishment of proxy model and ultimately solved the optimal parameters.

78 FR 76627 - Health Information Technology Standards Committee Advisory Meeting: Notice of Meeting

Science.gov (United States)

2013-12-18

... DEPARTMENT OF HEALTH AND HUMAN SERVICES Health Information Technology Standards Committee Advisory Meeting: Notice of Meeting AGENCY: Office of the National Coordinator for Health Information Technology... committee of the Office of the National Coordinator for Health Information Technology (ONC). These meeting...

Logic Meeting

CERN Document Server

Tugué, Tosiyuki; Slaman, Theodore

1989-01-01

These proceedings include the papers presented at the logic meeting held at the Research Institute for Mathematical Sciences, Kyoto University, in the summer of 1987. The meeting mainly covered the current research in various areas of mathematical logic and its applications in Japan. Several lectures were also presented by logicians from other countries, who visited Japan in the summer of 1987.

75 FR 56608 - Agency Meeting

Science.gov (United States)

2010-09-16

... SECURITIES AND EXCHANGE COMMISSION Agency Meeting Federal Register Citation of Previous Announcement: [To be published] Status: Open Meeting. Place: 100 F. Street, NE., Washington, DC. Date and Time of Previously Announced Meeting: September 15, 2010. Change In the Meeting: Room Change. The Joint...

Genetic algorithms

Science.gov (United States)

Wang, Lui; Bayer, Steven E.

1991-01-01

Genetic algorithms are mathematical, highly parallel, adaptive search procedures (i.e., problem solving methods) based loosely on the processes of natural genetics and Darwinian survival of the fittest. Basic genetic algorithms concepts are introduced, genetic algorithm applications are introduced, and results are presented from a project to develop a software tool that will enable the widespread use of genetic algorithm technology.

Evaluating meeting support tools

NARCIS (Netherlands)

Post, W.M.; Huis in't Veld, M.A.A.; Boogaard, S.A.A. van den

2008-01-01

Many attempts are underway for developing meeting support tools, but less attention is paid to the evaluation of meetingware. This article describes the development and testing of an instrument for evaluating meeting tools. First, we specified the object of evaluation - meetings - by means of a set

Evaluating meeting support tools

NARCIS (Netherlands)

Post, W.M.; Huis in 't Veld, M. M.A.; Boogaard, S.A.A. van den

2007-01-01

Many attempts are underway for developing meeting support tools, but less attention is paid to the evaluation of meetingware. This article describes the development and testing of an instrument for evaluating meeting tools. First, we specified the object of evaluation -meetings- by means of a set of

76 FR 54536 - Meeting

Science.gov (United States)

2011-09-01

... UNITED STATES INSTITUTE OF PEACE Meeting AGENCY: United States Institute of Peace. Date/Time... Peace Act, Public Law 98-525. Agenda: September 22, 2011 Board Meeting; Approval of Minutes of the One Hundred Fortieth Meeting (June 23-24, 2011) of the Board of Directors; Chairman's Report; President's...

Good laboratory practices for biochemical genetic testing and newborn screening for inherited metabolic disorders.

Science.gov (United States)

2012-04-06

Biochemical genetic testing and newborn screening are essential laboratory services for the screening, detection, diagnosis, and monitoring of inborn errors of metabolism or inherited metabolic disorders. Under the Clinical Laboratory Improvement Amendments of 1988 (CLIA) regulations, laboratory testing is categorized on the basis of the level of testing complexity as either waived (i.e., from routine regulatory oversight) or nonwaived testing (which includes tests of moderate and high complexity). Laboratories that perform biochemical genetic testing are required by CLIA regulations to meet the general quality systems requirements for nonwaived testing and the personnel requirements for high-complexity testing. Laboratories that perform public health newborn screening are subject to the same CLIA regulations and applicable state requirements. As the number of inherited metabolic diseases that are included in state-based newborn screening programs continues to increase, ensuring the quality of performance and delivery of testing services remains a continuous challenge not only for public health laboratories and other newborn screening facilities but also for biochemical genetic testing laboratories. To help ensure the quality of laboratory testing, CDC collaborated with the Centers for Medicare & Medicaid Services, the Food and Drug Administration, the Health Resources and Services Administration, and the National Institutes of Health to develop guidelines for laboratories to meet CLIA requirements and apply additional quality assurance measures for these areas of genetic testing. This report provides recommendations for good laboratory practices that were developed based on recommendations from the Clinical Laboratory Improvement Advisory Committee, with additional input from the Secretary's Advisory Committee on Genetics, Health, and Society; the Secretary's Advisory Committee on Heritable Disorders in Newborns and Children; and representatives of newborn

77 FR 55837 - Board Meeting

Science.gov (United States)

2012-09-11

... FARM CREDIT SYSTEM INSURANCE CORPORATION Board Meeting AGENCY: Farm Credit System Insurance Corporation. ACTION: Regular meeting. SUMMARY: Notice is hereby given of the regular meeting of the Farm Credit System Insurance Corporation Board (Board). Date and Time: The meeting of the Board will be held...

Current issues in medically assisted reproduction and genetics in Europe: research, clinical practice, ethics, legal issues and policy. European Society of Human Genetics and European Society of Human Reproduction and Embryology.

Science.gov (United States)

Harper, Joyce C; Geraedts, Joep; Borry, Pascal; Cornel, Martina C; Dondorp, Wybo; Gianaroli, Luca; Harton, Gary; Milachich, Tanya; Kääriäinen, Helena; Liebaers, Inge; Morris, Michael; Sequeiros, Jorge; Sermon, Karen; Shenfield, Françoise; Skirton, Heather; Soini, Sirpa; Spits, Claudia; Veiga, Anna; Vermeesch, Joris Robert; Viville, Stéphane; de Wert, Guido; Macek, Milan

2013-11-01

In March 2005, a group of experts from the European Society of Human Genetics and European Society of Human Reproduction and Embryology met to discuss the interface between genetics and assisted reproductive technology (ART), and published an extended background paper, recommendations and two Editorials. Seven years later, in March 2012, a follow-up interdisciplinary workshop was held, involving representatives of both professional societies, including experts from the European Union Eurogentest2 Coordination Action Project. The main goal of this meeting was to discuss developments at the interface between clinical genetics and ARTs. As more genetic causes of reproductive failure are now recognised and an increasing number of patients undergo testing of their genome before conception, either in regular health care or in the context of direct-to-consumer testing, the need for genetic counselling and preimplantation genetic diagnosis (PGD) may increase. Preimplantation genetic screening (PGS) thus far does not have evidence from randomised clinical trials to substantiate that the technique is both effective and efficient. Whole-genome sequencing may create greater challenges both in the technological and interpretational domains, and requires further reflection about the ethics of genetic testing in ART and PGD/PGS. Diagnostic laboratories should be reporting their results according to internationally accepted accreditation standards (International Standards Organisation - ISO 15189). Further studies are needed in order to address issues related to the impact of ART on epigenetic reprogramming of the early embryo. The legal landscape regarding assisted reproduction is evolving but still remains very heterogeneous and often contradictory. The lack of legal harmonisation and uneven access to infertility treatment and PGD/PGS fosters considerable cross-border reproductive care in Europe and beyond. The aim of this paper is to complement previous publications and provide

5 CFR 1206.11 - Meeting place.

Science.gov (United States)

2010-01-01

... 5 Administrative Personnel 3 2010-01-01 2010-01-01 false Meeting place. 1206.11 Section 1206.11 Administrative Personnel MERIT SYSTEMS PROTECTION BOARD ORGANIZATION AND PROCEDURES OPEN MEETINGS Conduct of Meetings § 1206.11 Meeting place. The Board will hold open meetings in meeting rooms designated in the...

78 FR 52997 - Connected Vehicle Research Program Public Meeting; Notice of Public Meeting

Science.gov (United States)

2013-08-27

... DEPARTMENT OF TRANSPORTATION Connected Vehicle Research Program Public Meeting; Notice of Public... overview of the ITS JPO Connected Vehicle research program. The meeting will take place September 24 to 26... . The public meeting is the best opportunity to learn details about the Connected Vehicle research...

Making Meetings Work Better.

Science.gov (United States)

Standke, Linda

1978-01-01

Focusing on the increased use by trainers of off-site facilities for employee training meetings, this article looks at some improvements and the expanding market in the meeting site industry. It also highlights emerging trends in the industry and covers the growth of meeting planning into a profession. (EM)

1990 Fall Meeting Report

Science.gov (United States)

Chapman, David S.

The AGU 1990 Fall Meeting, held in San Francisco December 3-7, continued the steady growth trend for the western meeting set over the last decade. About 5200 members registered for the meeting and 3836 papers were given. The scientific kickoff to the meeting was provided by a Union session on initial results of the current Magellan mission to Venus. The mission was also the focus of a public lecture and short film on highlights of the mission and an extensive Union poster session.

75 FR 76006 - Regular Meeting

Science.gov (United States)

2010-12-07

... FARM CREDIT SYSTEM INSURANCE CORPORATION Regular Meeting AGENCY: Farm Credit System Insurance Corporation Board. ACTION: Regular meeting. SUMMARY: Notice is hereby given of the regular meeting of the Farm Credit System Insurance Corporation Board (Board). Date and Time: The meeting of the Board will be held...

77 FR 2541 - Board Meeting

Science.gov (United States)

2012-01-18

... FARM CREDIT SYSTEM INSURANCE CORPORATION Board Meeting AGENCY: Farm Credit System Insurance Corporation Board; Regular Meeting. SUMMARY: Notice is hereby given of the regular meeting of the Farm Credit System Insurance Corporation Board (Board). DATE AND TIME: The meeting of the Board will be held at the...

76 FR 3629 - Regular Meeting

Science.gov (United States)

2011-01-20

... Meeting SUMMARY: Notice is hereby given of the regular meeting of the Farm Credit System Insurance Corporation Board (Board). Date and Time: The meeting of the Board will be held at the offices of the Farm... meeting of the Board will be open to the [[Page 3630

78 FR 73190 - Sunshine Act Meeting

Science.gov (United States)

2013-12-05

... FEDERAL RESERVE SYSTEM Sunshine Act Meeting Agency Holding the Meeting: Board of Governors of the...., Washington, DC 20551. STATUS: Open. On the day of the meeting, you will be able to view the meeting via... webcast of the meeting. A link to the meeting documentation will also be available approximately 20...

78 FR 46361 - Trinity Adaptive Management Working Group; Public Meeting, Teleconference and Web-Based Meeting

Science.gov (United States)

2013-07-31

... stakeholders the opportunity to give policy, management, and technical input concerning Trinity River...-FF08EACT00] Trinity Adaptive Management Working Group; Public Meeting, Teleconference and Web-Based Meeting... Trinity Management Council (TMC). DATES: Public meeting, Teleconference, and web-based meeting: TAMWG and...

78 FR 17226 - Trinity Adaptive Management Working Group; Public Meeting, Teleconference and Web-Based Meeting

Science.gov (United States)

2013-03-20

... stakeholders the opportunity to give policy, management, and technical input concerning Trinity River...-FF08EACT00] Trinity Adaptive Management Working Group; Public Meeting, Teleconference and Web-Based Meeting... Service, announce a public meeting, teleconference and web-based meeting of the Trinity Adaptive...

78 FR 49281 - Trinity Adaptive Management Working Group; Public Meeting, Teleconference and Web-Based Meeting

Science.gov (United States)

2013-08-13

... opportunity to give policy, management, and technical input concerning Trinity River (California) restoration...-FF08EACT00] Trinity Adaptive Management Working Group; Public Meeting, Teleconference and Web-Based Meeting... Service, announce a public meeting, teleconference, and web-based meeting of the Trinity Adaptive...

From Genetics to Genetic Algorithms

Indian Academy of Sciences (India)

artificial genetic system) string feature or ... called the genotype whereas it is called a structure in artificial genetic ... assigned a fitness value based on the cost function. Better ..... way it has produced complex, intelligent living organisms capable of ...

75 FR 67393 - Notice of Public Meeting, Eastern Montana Resource Advisory Council Meeting

Science.gov (United States)

2010-11-02

... Public Meeting, Eastern Montana Resource Advisory Council Meeting AGENCY: Bureau of Land Management... 1972 (FACA), the U.S. Department of the Interior, Bureau of Land Management (BLM) Eastern Montana... Eastern Montana Resource Advisory Council will be held on Dec. 2, 2010 in Billings, Montana. The meeting...

75 FR 58350 - Meeting

Science.gov (United States)

2010-09-24

... UNITED STATES ARCTIC RESEARCH COMMISSION Meeting Notice is hereby given that the U.S. Arctic Research Commission will hold its 94th meeting in Fairbanks, AK, on October 6-8, 2010. The business session... approval of the agenda. (2) Approval of the minutes from the 93rd meeting. (3) Commissioners and staff...

From genetics to genomics in plants and animals

Directory of Open Access Journals (Sweden)

Todorovska Elena

2010-01-01

Full Text Available The classical concepts in plant and livestock selection for economically important quantitative traits traditionally are based on phenotypic records, aiming at improvement of the traits by obtaining better genetic gain. The increase in genetic variation together with shortening of the generation interval is the major target of long term improvement of methods and tools for selection activities. The discoveries and implementations of biotechnology and molecular biology for selection purposes provide a stable background for generating of new knowledge and practical use in agricultural research and practice as well as to meet the growing demand for more and with better quality food and feed. The innovations in molecular knowledge related to practical selection aside with the quick quantification in breeding schemes allowed to reconsider the opportunities for sustainable development of selection methods for improvement of the traits of interest in agriculture, the quick invention and practical application of new high-throughput technologies for studying of the genomic variation, evolution, translation of proteins and metabolite determination altogether put in an open and communicative environment of information technologies provide a new holistic platform for better research and more knowledge for practical application of selection decisions.

Reverse genetics with animal viruses. NSV reverse genetics

International Nuclear Information System (INIS)

Mebatsion, T.

2005-01-01

New strategies to genetically manipulate the genomes of several important animal pathogens have been established in recent years. This article focuses on the reverse genetics techniques, which enables genetic manipulation of the genomes of non-segmented negative-sense RNA viruses. Recovery of a negative-sense RNA virus entirely from cDNA was first achieved for rabies virus in 1994. Since then, reverse genetic systems have been established for several pathogens of medical and veterinary importance. Based on the reverse genetics technique, it is now possible to design safe and more effective live attenuated vaccines against important viral agents. In addition, genetically tagged recombinant viruses can be designed to facilitate serological differentiation of vaccinated animals from infected animals. The approach of delivering protective immunogens of different pathogens using a single vector was made possible with the introduction of the reverse genetics system, and these novel broad-spectrum vaccine vectors have potential applications in improving animal health in developing countries. (author)

21 CFR 312.47 - Meetings.

Science.gov (United States)

2010-04-01

... resources permit. The general principle underlying the conduct of such meetings is that there should be free...) “End-of-Phase 2” meetings and meetings held before submission of a marketing application. At specific... meetings held near completion of Phase 3 and before submission of a marketing application (“pre-NDA...

9th Transgenic Technology Meeting (TT2010) in Berlin, Germany: a meeting report.

Science.gov (United States)

Saunders, Thomas L; Sobieszczuk, Peter

2010-12-01

The first Transgenic Technology (TT) Meeting was organized in 1999 by Johannes Wilbertz, Karolinska Institute, Stockholm, Sweden as a regional meeting. The TT Meetings continued in this way, constantly gathering additional practitioners of transgenic methodologies until the breakthrough in 2005 when the 6th TT Meeting in Barcelona, Spain, hosted by Lluis Montoliu (Centro Nacional de Biotecnologia, Madrid, Spain), generated the momentum to establish the International Society for Transgenic Technologies (ISTT). Since 2006, the ISTT has continued to promote the TT Meetings and provide its membership with a forum to discuss best practices and new methods in the field. The TT2010 Meeting was held at the Max Delbrück Center for Molecular Medicine (Berlin, Germany). Participation at the TT2010 Meeting exceeded the registration capacity and set a new attendance record. Session topics included methods for the generation of rat and mouse models of human disease, fundamental and advanced topics in rodent embryonic stem cells, and the newest transgenic technologies. Short presentations from selected abstracts were of especial interest. Roundtable discussions on transgenic facility establishment and cryoarchiving of mouse lines were favorably received. Students, technical staff, and professors participated in numerous discussions and came away with practical methods and new ideas for research.

Potential applications of cryogenic technologies to plant genetic improvement and pathogen eradication.

Science.gov (United States)

Wang, Biao; Wang, Ren-Rui; Cui, Zhen-Hua; Bi, Wen-Lu; Li, Jing-Wei; Li, Bai-Quan; Ozudogru, Elif Aylin; Volk, Gayle M; Wang, Qiao-Chun

2014-01-01

Rapid increases in human populations provide a great challenge to ensure that adequate quantities of food are available. Sustainable development of agricultural production by breeding more productive cultivars and by increasing the productive potential of existing cultivars can help meet this demand. The present paper provides information on the potential uses of cryogenic techniques in ensuring food security, including: (1) long-term conservation of a diverse germplasm and successful establishment of cryo-banks; (2) maintenance of the regenerative ability of embryogenic tissues that are frequently the target for genetic transformation; (3) enhancement of genetic transformation and plant regeneration of transformed cells, and safe, long-term conservation for transgenic materials; (4) production and maintenance of viable protoplasts for transformation and somatic hybridization; and (5) efficient production of pathogen-free plants. These roles demonstrate that cryogenic technologies offer opportunities to ensure food security. Copyright © 2014 Elsevier Inc. All rights reserved.

Bioinformatics Meets Virology: The European Virus Bioinformatics Center's Second Annual Meeting.

Science.gov (United States)

Ibrahim, Bashar; Arkhipova, Ksenia; Andeweg, Arno C; Posada-Céspedes, Susana; Enault, François; Gruber, Arthur; Koonin, Eugene V; Kupczok, Anne; Lemey, Philippe; McHardy, Alice C; McMahon, Dino P; Pickett, Brett E; Robertson, David L; Scheuermann, Richard H; Zhernakova, Alexandra; Zwart, Mark P; Schönhuth, Alexander; Dutilh, Bas E; Marz, Manja

2018-05-14

The Second Annual Meeting of the European Virus Bioinformatics Center (EVBC), held in Utrecht, Netherlands, focused on computational approaches in virology, with topics including (but not limited to) virus discovery, diagnostics, (meta-)genomics, modeling, epidemiology, molecular structure, evolution, and viral ecology. The goals of the Second Annual Meeting were threefold: (i) to bring together virologists and bioinformaticians from across the academic, industrial, professional, and training sectors to share best practice; (ii) to provide a meaningful and interactive scientific environment to promote discussion and collaboration between students, postdoctoral fellows, and both new and established investigators; (iii) to inspire and suggest new research directions and questions. Approximately 120 researchers from around the world attended the Second Annual Meeting of the EVBC this year, including 15 renowned international speakers. This report presents an overview of new developments and novel research findings that emerged during the meeting.

Proceedings - BORDEAUX VIVA WINTER SCHOOL - XXXIII LIAC MEETING

Directory of Open Access Journals (Sweden)

Thierry Couffinhal

2017-12-01

Full Text Available BORDEAUX VIVA WINTER SCHOOL - XXXIII LIAC MEETING 29 November to 1 December | 29 Novembro a 1 Dezembro DOI: 10.19277/bbr.14.2.169 Biomedical and Biopharmaceutical Research Jornal de Investigação Biomédica e Biofarmacêutica Supplement  │  Suplemento Biomed Biopharm Res. ,  2017; (14 2: , 287-309 Program 29 Novembrer | 29 de Novembro Reception of participant Winter School Meeting Winter School meeting (organizers: A. Bikfalvi & J. Badaut Presentation of students - What should be achieved in this winter school Opening meeting : Thierry Couffinhal (VIVA action, Director & Michel Spina (LIAC President CLINICAL AND EPIDEMIOLOGIC ASPECT OF VASCULAR AGING (chairmen: C. Tzourio & L. Monteiro Early vascular aging - P.M. NILSSON, Malmö - Sweden Neurovascular epidemiology of aging - C. TZOURIO, Bordeaux Cardiovascular epidemiology of aging - P. BOUTOUYRIE, Paris Forecasted trends in disability and life expectancy - S. AHMADI-ABHARI, Liverpool - UK Neurovascular genetic epidemiology - S. DEBETTE, Bordeaux Vascular and thrombosis genetic epidemiology - D. TREGOUET, Paris SELECTED ORAL PRESENTATION (Chairmen: S. Debette & J. Badaut • Mitochondrial function regulates vascular aging in mice - K. FOOTE, Cambridge - UK • Structural imaging of the vascular wall - S. ALMAGRO, Reims • Numerical assessment and comparison of pulse wave velocity methods aiming at measuring aortic stiffness - H. OBEID, Paris • Long-term trajectories of cardiometabolic risk factors in prodromal dementia: the Three-City Study - M. WAGNER, Bordeaux EVENING PHILOSOPHICAL CONFERENCE ANTONIO-MARIO TAMBURRO (chairman: M. Spina When does the vascular system age and when is there a disease? Conceptual and theoretical issues - M. LEMOINE, Tours 30 Novembrer | 30 de Novembro PATHOPHYSIOLOGIC FEATURES OF VASCULAR AGING (Chairmen: J.F. Arnal & M. Formato From physiological aging to pathological aging - J.B. MICHEL, Paris Physiological models to study the human microcirculation

Genetically modified foods: safety, risks and public concerns-a review.

Science.gov (United States)

Bawa, A S; Anilakumar, K R

2013-12-01

Genetic modification is a special set of gene technology that alters the genetic machinery of such living organisms as animals, plants or microorganisms. Combining genes from different organisms is known as recombinant DNA technology and the resulting organism is said to be 'Genetically modified (GM)', 'Genetically engineered' or 'Transgenic'. The principal transgenic crops grown commercially in field are herbicide and insecticide resistant soybeans, corn, cotton and canola. Other crops grown commercially and/or field-tested are sweet potato resistant to a virus that could destroy most of the African harvest, rice with increased iron and vitamins that may alleviate chronic malnutrition in Asian countries and a variety of plants that are able to survive weather extremes. There are bananas that produce human vaccines against infectious diseases such as hepatitis B, fish that mature more quickly, fruit and nut trees that yield years earlier and plants that produce new plastics with unique properties. Technologies for genetically modifying foods offer dramatic promise for meeting some areas of greatest challenge for the 21st century. Like all new technologies, they also pose some risks, both known and unknown. Controversies and public concern surrounding GM foods and crops commonly focus on human and environmental safety, labelling and consumer choice, intellectual property rights, ethics, food security, poverty reduction and environmental conservation. With this new technology on gene manipulation what are the risks of "tampering with Mother Nature"?, what effects will this have on the environment?, what are the health concerns that consumers should be aware of? and is recombinant technology really beneficial? This review will also address some major concerns about the safety, environmental and ecological risks and health hazards involved with GM foods and recombinant technology.

Public meeting

CERN Multimedia

HR Department

2010-01-01

Dear Colleagues, I am pleased to invite you to a public meeting which will be held on Thursday 11 November 2010 at 2:30 p.m., in the Main Auditorium (welcome coffee from 2 p.m.) In this meeting Sigurd Lettow, Director for Administration and General Infrastructure will present the Management’s proposals towards restoring full funding of the Pension Fund. The meeting will follow discussions which took place with the Staff Association, at the Standing Concertation Committee (CCP) of 1 November 2010 and will be held with the Members States, at the Tripartite Employment Conditions Forum (TREF) of 4 November 2010. You will be able to attend this presentation in the Main Auditorium or via the webcast. The Management will also be available to reply to your questions on this subject. Best regards, Anne-Sylvie Catherin

The art of leading meetings.

Science.gov (United States)

English, C B

1987-05-01

The ability to skillfully lead meetings can contribute to a manager's effectiveness. There are four types of meetings, each serving different needs and requiring different leadership. A manager must know when to hold meetings, what leadership style is appropriate, how and when to use participative management, and how to facilitate a consensus. Considerable planning must be done before a meeting is held. Various leadership and communication skills are required to effectively open, conduct, and close a meeting. Finally, the leader needs to know how to deal with participants who become problems.

A general population genetic framework for antagonistic selection that accounts for demography and recurrent mutation.

Science.gov (United States)

Connallon, Tim; Clark, Andrew G

2012-04-01

Antagonistic selection--where alleles at a locus have opposing effects on male and female fitness ("sexual antagonism") or between components of fitness ("antagonistic pleiotropy")--might play an important role in maintaining population genetic variation and in driving phylogenetic and genomic patterns of sexual dimorphism and life-history evolution. While prior theory has thoroughly characterized the conditions necessary for antagonistic balancing selection to operate, we currently know little about the evolutionary interactions between antagonistic selection, recurrent mutation, and genetic drift, which should collectively shape empirical patterns of genetic variation. To fill this void, we developed and analyzed a series of population genetic models that simultaneously incorporate these processes. Our models identify two general properties of antagonistically selected loci. First, antagonistic selection inflates heterozygosity and fitness variance across a broad parameter range--a result that applies to alleles maintained by balancing selection and by recurrent mutation. Second, effective population size and genetic drift profoundly affect the statistical frequency distributions of antagonistically selected alleles. The "efficacy" of antagonistic selection (i.e., its tendency to dominate over genetic drift) is extremely weak relative to classical models, such as directional selection and overdominance. Alleles meeting traditional criteria for strong selection (N(e)s > 1, where N(e) is the effective population size, and s is a selection coefficient for a given sex or fitness component) may nevertheless evolve as if neutral. The effects of mutation and demography may generate population differences in overall levels of antagonistic fitness variation, as well as molecular population genetic signatures of balancing selection.

Public meetings

CERN Multimedia

Staff Association

2017-01-01

Do you have questions about the elections to the Staff Council, 2017 MERIT exercise, EVE and School, LD to IC exercise, CHIS, the Pension Fund… Come get informed and ask your questions at our public meetings. These public meetings are also an opportunity to get the more information on current issues. Benefit from this occasion to get the latest news and to discuss with the representatives of the statutory body that is the Staff Association!

Experiencing the genetic body: parents' encounters with pediatric clinical genetics.

Science.gov (United States)

Raspberry, Kelly; Skinner, Debra

2007-01-01

Because of advancements in genetic research and technologies, the clinical practice of genetics is becoming a prevalent component of biomedicine. As the genetic basis for more and more diseases are found, it is possible that ways of experiencing health, illness, identity, kin relations, and the body are becoming geneticized, or understood within a genetic model of disease. Yet, other models and relations that go beyond genetic explanations also shape interpretations of health and disease. This article explores how one group of individuals for whom genetic disorder is highly relevant formulates their views of the body in light of genetic knowledge. Using data from an ethnographic study of 106 parents or potential parents of children with known or suspected genetic disorders who were referred to a pediatric genetic counseling and evaluation clinic in the southeastern United States, we find that these parents do, to some degree, perceive of their children's disorders in terms of a genetic body that encompasses two principal qualities: a sense of predetermined health and illness and an awareness of a profound historicity that reaches into the past and extends into the present and future. They experience this genetic body as both fixed and historical, but they also express ideas of a genetic body made less deterministic by their own efforts and future possibilities. This account of parents' experiences with genetics and clinical practice contributes to a growing body of work on the ways in which genetic information and technologies are transforming popular and medical notions of the body, and with it, health, illness, kinship relations, and personal and social identities.

"What is this genetics, anyway?" Understandings of genetics, illness causality and inheritance among British Pakistani users of genetic services.

Science.gov (United States)

Shaw, Alison; Hurst, Jane A

2008-08-01

Misconceptions about basic genetic concepts and inheritance patterns may be widespread in the general population. This paper investigates understandings of genetics, illness causality and inheritance among British Pakistanis referred to a UK genetics clinic. During participant observation of genetics clinic consultations and semi-structured interviews in Urdu or English in respondents' homes, we identified an array of environmental, behavioral and spiritual understandings of the causes of medical and intellectual problems. Misconceptions about the location of genetic information in the body and of genetic mechanisms of inheritance were common, reflected the range of everyday theories observed for White British patients and included the belief that a child receives more genetic material from the father than the mother. Despite some participants' conversational use of genetic terminology, some patients had assimilated genetic information in ways that conflict with genetic theory with potentially serious clinical consequences. Additionally, skepticism of genetic theories of illness reflected a rejection of a dominant discourse of genetic risk that stigmatizes cousin marriages. Patients referred to genetics clinics may not easily surrender their lay or personal theories about the causes of their own or their child's condition and their understandings of genetic risk. Genetic counselors may need to identify, work with and at times challenge patients' understandings of illness causality and inheritance.

Reviews in Modern Astronomy: Vol. 15: JENAM 2001: Astronomy with Large Telescopes from Ground and Space

Science.gov (United States)

Schielicke, Reinhard E.

2002-11-01

This 15th volume in the annual series on recent developments and scientific progress in astronomy and astrophysics contains fourteen invited reviews presented during the Joint European and National Astronomical Meeting JENAM 2001, held in Munich, Germany. Readers also learn about the lecture on macro- and microscopic views of nearby galaxies given by Keiichi Kodaira, Japan, who was awarded the Karl Schwarzschild medal 2001. Further contributions on the topic provide the latest results on the search for extra-solar planets, formation of stars and galaxies, physics of active galactic nuclei, as well as new telescopes and sensor technologies for various wavelengths.

International Youth Library

Directory of Open Access Journals (Sweden)

Osman Ümit Özen

1994-03-01

Full Text Available International Youth Library, the biggest youth library in the world, was founded in 1948 in Munich, Germany, by Jella Lepman. She aimed to unite all the children of the world through books by establishing this library. IYL is still trying to achieve this end supporting scholarship programmes in children’s literature research, participating in or organizing meetings on children’s literature, and working with other national and international organizations deeding with children’s literature. Unfortunately the library is facing some problems recently which have risen from economic difficulties which also inhibits promotional activities.

Tanaman Genetically Modified Organism (GMO dan Perspektif Hukumnya di Indonesia

Directory of Open Access Journals (Sweden)

Yuwono Prianto

2017-08-01

Full Text Available Abstrak Genetically modified organism (GMO merupakan organisme yang gen-gennya telah diubah dengan menggunakan teknik rekayasa genetika. Produk rekayasa genetika diklasifikasikan menjadi 4 macam, yaitu generasi pertama: satu sifat; generasi kedua: kumpulan sifat; generasi ketiga dan keempat: near-intragenic, intragenic, dan cisgenic. Adapun produk rekayasa genetika pada tanaman di Indonesia di antaranya adalah padi, tomat, tebu, singkong, dan kentang. Regulasi tanaman hasil rekayasa genetika diatur oleh beberapa lembaga, di antaranya Kementerian Lingkungan Hidup, Kementerian Pertanian, Komisi Keamanan Hayati, Tim Teknis Keamanan Hayati, dan Biosafety Clearing House, berdasarkan peraturan pemerintah No. 21 tahun 2005. Pengujian yang dilakukan pada produk rekayasa genetika meliputi analisis sumber gen penyebab alergi, sekuens homolog asam amino, resistensi pepsin, skrining serum, serta penggunaan hewan uji. Berbagai produk GMO di Indonesia sejauh ini merupakan produk yang dibutuhkan dalam memenuhi kebutuhan hidup sehari-hari, yang perlu diawasi secara ketat dari segi dampaknya terhadap lingkungan melalui ketentuan hukum yang berlaku, yang diwakili oleh instansi-instansi terkait tersebut.Abstract Genetically modified organism (GMO is an organism whose genes that have been altered by using genetic engineering techniques. Genetic engineering products are classified into 4 types, which are the first generation: one trait; the second generation: a collection of properties; the third and fourth generation: near-intragenic, intragenic, and cisgenic. The genetic engineering products in plants in Indonesia include rice, tomatoes, sugar cane, cassava, and potatoes. The application of the genetically engineered crops is regulated by several institutions, including the Ministry of Environment, the Ministry of Agriculture, the Biosafety Commission, the Biosafety Technical Team and the Biosafety Clearing House, under government regulation No. 21 of the year

77 FR 57567 - HIT Policy Committee Advisory Meeting; Notice of Meeting

Science.gov (United States)

2012-09-18

... DEPARTMENT OF HEALTH AND HUMAN SERVICES HIT Policy Committee Advisory Meeting; Notice of Meeting AGENCY: Office of the National Coordinator for Health Information Technology, HHS. ACTION: Notice of... of Committee: HIT Policy Committee. General Function of the Committee: To provide recommendations to...

77 FR 50690 - HIT Policy Committee Advisory Meeting; Notice of Meeting

Science.gov (United States)

2012-08-22

... DEPARTMENT OF HEALTH AND HUMAN SERVICES HIT Policy Committee Advisory Meeting; Notice of Meeting AGENCY: Office of the National Coordinator for Health Information Technology, HHS. ACTION: Notice of... of Committee: HIT Policy Committee. General Function of the Committee: To provide recommendations to...

77 FR 15760 - HIT Policy Committee Advisory Meeting; Notice of Meeting

Science.gov (United States)

2012-03-16

... DEPARTMENT OF HEALTH AND HUMAN SERVICES HIT Policy Committee Advisory Meeting; Notice of Meeting AGENCY: Office of the National Coordinator for Health Information Technology, HHS. ACTION: Notice of... of Committee: HIT Policy Committee. General Function of the Committee: To provide recommendations to...

76 FR 39108 - HIT Policy Committee Advisory Meeting; Notice of Meeting

Science.gov (United States)

2011-07-05

... DEPARTMENT OF HEALTH AND HUMAN SERVICES HIT Policy Committee Advisory Meeting; Notice of Meeting AGENCY: Office of the National Coordinator for Health Information Technology, HHS ACTION: Notice of... the public. Name of Committee: HIT Policy Committee. General Function of the Committee: to provide...

77 FR 37407 - HIT Policy Committee Advisory Meeting; Notice of Meeting

Science.gov (United States)

2012-06-21

... DEPARTMENT OF HEALTH AND HUMAN SERVICES HIT Policy Committee Advisory Meeting; Notice of Meeting AGENCY: Office of the National Coordinator for Health Information Technology, HHS. ACTION: Notice of... of Committee: HIT Policy Committee. General Function of the Committee: To provide recommendations to...

75 FR 21629 - HIT Standards Committee's Workgroup Meetings; Notice of Meetings

Science.gov (United States)

2010-04-26

... Technology; HIT Standards Committee's Workgroup Meetings; Notice of Meetings AGENCY: Office of the National... only. Name of Committees: HIT Standards Committee's Workgroups: Clinical Operations Vocabulary... developed by the HIT Policy Committee. Date and Time: The HIT Standards Committee Workgroups will hold the...

76 FR 22397 - HIT Policy Committee Advisory Meeting; Notice of Meeting

Science.gov (United States)

2011-04-21

... DEPARTMENT OF HEALTH AND HUMAN SERVICES HIT Policy Committee Advisory Meeting; Notice of Meeting AGENCY: Office of the National Coordinator for Health Information Technology, HHS. ACTION: Notice of... of Committee: HIT Policy Committee. General Function of the Committee: To provide recommendations to...

77 FR 22787 - HIT Policy Committee Advisory Meeting; Notice of Meeting

Science.gov (United States)

2012-04-17

... DEPARTMENT OF HEALTH AND HUMAN SERVICES HIT Policy Committee Advisory Meeting; Notice of Meeting AGENCY: Office of the National Coordinator for Health Information Technology, HHS. ACTION: Notice of... of Committee: HIT Policy Committee. General Function of the Committee: To provide recommendations to...

77 FR 27459 - HIT Policy Committee Advisory Meeting; Notice of Meeting

Science.gov (United States)

2012-05-10

... DEPARTMENT OF HEALTH AND HUMAN SERVICES HIT Policy Committee Advisory Meeting; Notice of Meeting AGENCY: Office of the National Coordinator for Health Information Technology, HHS. ACTION: Notice of... of Committee: HIT Policy Committee. General Function of the Committee: to provide recommendations to...

76 FR 28783 - HIT Policy Committee Advisory Meeting; Notice of Meeting

Science.gov (United States)

2011-05-18

... DEPARTMENT OF HEALTH AND HUMAN SERVICES HIT Policy Committee Advisory Meeting; Notice of Meeting AGENCY: Office of the National Coordinator for Health Information Technology, HHS. ACTION: Notice of... of Committee: HIT Policy Committee. General Function of the Committee: To provide recommendations to...

76 FR 79684 - HIT Policy Committee Advisory Meeting; Notice of Meeting

Science.gov (United States)

2011-12-22

... DEPARTMENT OF HEALTH AND HUMAN SERVICES HIT Policy Committee Advisory Meeting; Notice of Meeting AGENCY: Office of the National Coordinator for Health Information Technology, HHS. ACTION: Notice of... of Committee: HIT Policy Committee. General Function of the Committee: To provide recommendations to...

75 FR 29762 - HIT Policy Committee's Workgroup Meetings; Notice of Meetings

Science.gov (United States)

2010-05-27

... Technology HIT Policy Committee's Workgroup Meetings; Notice of Meetings AGENCY: Office of the National... only. Name of Committees: HIT Policy Committee's Workgroups: Meaningful Use, Privacy & Security Policy... specifications, and certification criteria are needed. Date and Time: The HIT Policy Committee Workgroups will...

77 FR 73660 - HIT Policy Committee Advisory Meetings; Notice of Meetings

Science.gov (United States)

2012-12-11

... DEPARTMENT OF HEALTH AND HUMAN SERVICES HIT Policy Committee Advisory Meetings; Notice of Meetings AGENCY: Office of the National Coordinator for Health Information Technology, HHS. ACTION: Notice of... of Committee: HIT Policy Committee. General Function of the Committee: To provide recommendations to...

77 FR 28881 - HIT Policy Committee Advisory Meeting; Notice of Meeting

Science.gov (United States)

2012-05-16

... DEPARTMENT OF HEALTH AND HUMAN SERVICES HIT Policy Committee Advisory Meeting; Notice of Meeting AGENCY: Office of the National Coordinator for Health Information Technology, HHS. ACTION: Notice of... of Committee: HIT Policy Committee. General Function of the Committee: to provide recommendations to...

76 FR 46298 - HIT Policy Committee Advisory Meeting; Notice of Meeting

Science.gov (United States)

2011-08-02

... DEPARTMENT OF HEALTH AND HUMAN SERVICES HIT Policy Committee Advisory Meeting; Notice of Meeting AGENCY: Office of the National Coordinator for Health Information Technology, HHS. ACTION: Notice of... of Committee: HIT Policy Committee. General Function of the Committee: To provide recommendations to...

77 FR 65691 - HIT Policy Committee Advisory Meeting; Notice of Meeting

Science.gov (United States)

2012-10-30

... DEPARTMENT OF HEALTH AND HUMAN SERVICES HIT Policy Committee Advisory Meeting; Notice of Meeting AGENCY: Office of the National Coordinator for Health Information Technology, HHS. ACTION: Notice of... of Committee: HIT Policy Committee. General Function of the Committee: To provide recommendations to...

76 FR 70455 - HIT Policy Committee Advisory Meeting; Notice of Meeting

Science.gov (United States)

2011-11-14

... DEPARTMENT OF HEALTH AND HUMAN SERVICES HIT Policy Committee Advisory Meeting; Notice of Meeting AGENCY: Office of the National Coordinator for Health Information Technology, HHS. ACTION: Notice of... of Committee: HIT Policy Committee. General Function of the Committee: to provide recommendations to...

77 FR 2727 - HIT Policy Committee Advisory Meeting; Notice of Meeting

Science.gov (United States)

2012-01-19

... DEPARTMENT OF HEALTH AND HUMAN SERVICES HIT Policy Committee Advisory Meeting; Notice of Meeting AGENCY: Office of the National Coordinator for Health Information Technology, HHS. ACTION: Notice of... of Committee: HIT Policy Committee. General Function of the Committee: To provide recommendations to...

76 FR 14975 - HIT Policy Committee Advisory Meeting; Notice of Meeting

Science.gov (United States)

2011-03-18

... DEPARTMENT OF HEALTH AND HUMAN SERVICES HIT Policy Committee Advisory Meeting; Notice of Meeting AGENCY: Office of the National Coordinator for Health Information Technology, HHS. ACTION: Notice of... of Committee: HIT Policy Committee. General Function of the Committee: to provide recommendations to...

76 FR 50734 - HIT Policy Committee Advisory Meeting; Notice of Meeting

Science.gov (United States)

2011-08-16

... DEPARTMENT OF HEALTH AND HUMAN SERVICES HIT Policy Committee Advisory Meeting; Notice of Meeting AGENCY: Office of the National Coordinator for Health Information Technology, HHS. ACTION: Notice of... of Committee: HIT Policy Committee. General Function of the Committee: To provide recommendations to...

76 FR 55912 - HIT Policy Committee Advisory Meeting; Notice of Meeting

Science.gov (United States)

2011-09-09

... DEPARTMENT OF HEALTH AND HUMAN SERVICES HIT Policy Committee Advisory Meeting; Notice of Meeting AGENCY: Office of the National Coordinator for Health Information Technology, HHS. ACTION: Notice of... the public. Name of Committee: HIT Policy Committee. General Function of the Committee: To provide...

77 FR 41788 - HIT Policy Committee Advisory Meeting; Notice of Meeting

Science.gov (United States)

2012-07-16

... DEPARTMENT OF HEALTH AND HUMAN SERVICES HIT Policy Committee Advisory Meeting; Notice of Meeting AGENCY: Office of the National Coordinator for Health Information Technology, HHS. ACTION: Notice of... of Committee: HIT Policy Committee. General Function of the Committee: To provide recommendations to...

76 FR 39107 - HIT Standards Committee's Workgroup Meetings; Notice of Meetings

Science.gov (United States)

2011-07-05

... DEPARTMENT OF HEALTH AND HUMAN SERVICES HIT Standards Committee's Workgroup Meetings; Notice of Meetings AGENCY: Office of the National Coordinator for Health Information Technology, HHS. ACTION: Notice... of the Office of the National Coordinator for Health Information Technology (ONC). The [[Page 39108...

45 CFR 1703.301 - Meeting place.

Science.gov (United States)

2010-10-01

... 45 Public Welfare 4 2010-10-01 2010-10-01 false Meeting place. 1703.301 Section 1703.301 Public... INFORMATION SCIENCE GOVERNMENT IN THE SUNSHINE ACT Conduct of Meetings § 1703.301 Meeting place. Meetings will be held in meeting rooms designated in the public announcement. Whenever the number of observers is...

The alliance between genetic biobanks and patient organisations: the experience of the telethon network of genetic biobanks.

Science.gov (United States)

Baldo, Chiara; Casareto, Lorena; Renieri, Alessandra; Merla, Giuseppe; Garavaglia, Barbara; Goldwurm, Stefano; Pegoraro, Elena; Moggio, Maurizio; Mora, Marina; Politano, Luisa; Sangiorgi, Luca; Mazzotti, Raffaella; Viotti, Valeria; Meloni, Ilaria; Pellico, Maria Teresa; Barzaghi, Chiara; Wang, Chiuhui Mary; Monaco, Lucia; Filocamo, Mirella

2016-10-24

Rare diseases (RDs) are often neglected because they affect a small percentage of the population (6-8 %), which makes research and development of new therapies challenging processes. Easy access to high-quality samples and associated clinical data is therefore a key prerequisite for biomedical research. In this context, Genetic Biobanks are critical to developing basic, translational and clinical research on RDs. The Telethon Network of Genetic Biobanks (TNGB) is aware of the importance of biobanking as a service for patients and has started a dialogue with RD-Patient Organisations via promotion of dedicated meetings and round-tables, as well as by including their representatives on the TNGB Advisory Board. This has enabled the active involvement of POs in drafting biobank policies and procedures, including those concerning ethical issues. Here, we report on our experience with RD-Patient Organisations who have requested the services of existing biobanks belonging to TNGB and describe how these relationships were established, formalised and maintained. The process of patient engagement has proven to be successful both for lay members, who increased their understanding of the complex processes of biobanking, and for professionals, who gained awareness of the needs and expectations of the people involved. This collaboration has resulted in a real interest on the part of Patient Organisations in the biobanking service, which has led to 13 written agreements designed to formalise this process. These agreements enabled the centralisation of rare genetic disease biospecimens and their related data, thus making them available to the scientific community. The TNGB experience has proven to be an example of good practice with regard to patient engagement in biobanking and may serve as a model of collaboration between disease-oriented Biobanks and Patient Organisations. Such collaboration serves to enhance awareness and trust and to encourage the scientific community to

ACCU Meeting

CERN Multimedia

PH Department

2011-01-01

DRAFT Agenda for the meeting to be held on Wednesday 9 March 2011 At 9:15 a.m. in room 60-6-002   Chairperson's remarks Adoption of the agenda Minutes of the previous meeting Matters arising News from the CERN Management Report on services from GS department Update on Safety at CERN The new account management system Users’ Office news Any Other Business Agenda for the next meeting   Anyone wishing to raise any points under item 10 is invited to send them to the Chairperson in writing or by e-mail to Michael.Hauschild@cern.ch Michael Hauschild (Secretary) ACCU is the forum for discussion between the CERN Management and the representatives of CERN Users to review the practical means taken by CERN for the work of Users of the Laboratory. The User Representatives to ACCU are (CERN internal telephone numbers in brackets): Austria G. Walzel (76592) Belgium ...

76 FR 46298 - HIT Standards Committee Advisory Meeting; Notice of Meeting

Science.gov (United States)

2011-08-02

... DEPARTMENT OF HEALTH AND HUMAN SERVICES HIT Standards Committee Advisory Meeting; Notice of... public. Name of Committee: HIT Standards Committee. General Function of the Committee: to provide... developed by the HIT Policy Committee. Date and Time: The meeting will be held virtually on August 17, 2011...

76 FR 50734 - HIT Standards Committee Advisory Meeting; Notice of Meeting

Science.gov (United States)

2011-08-16

... DEPARTMENT OF HEALTH AND HUMAN SERVICES HIT Standards Committee Advisory Meeting; Notice of... public. Name of Committee: HIT Standards Committee. General Function of the Committee: to provide... developed by the HIT Policy Committee. Date and Time: The meeting will be held on September 28, 2011, from 9...

77 FR 2727 - HIT Standards Committee Advisory Meeting; Notice of Meeting

Science.gov (United States)

2012-01-19

... DEPARTMENT OF HEALTH AND HUMAN SERVICES HIT Standards Committee Advisory Meeting; Notice of... public. Name of Committee: HIT Standards Committee. General Function of the Committee: To provide... developed by the HIT Policy Committee. Date and Time: The meeting will be held on February 29, 2012, from 9...

76 FR 70455 - HIT Standards Committee Advisory Meeting; Notice of Meeting

Science.gov (United States)

2011-11-14

... DEPARTMENT OF HEALTH AND HUMAN SERVICES HIT Standards Committee Advisory Meeting; Notice of... public. Name of Committee: HIT Standards Committee. General Function of the Committee: to provide... developed by the HIT Policy Committee. Date and Time: The meeting will be held on December 14, 2011, from 9...

77 FR 73661 - HIT Standards Committee Advisory Meetings; Notice of Meetings

Science.gov (United States)

2012-12-11

... DEPARTMENT OF HEALTH AND HUMAN SERVICES HIT Standards Committee Advisory Meetings; Notice of... public. Name of Committee: HIT Standards Committee. General Function of the Committee: To provide... developed by the HIT Policy Committee. Date and Time: These meetings will be held on the following dates and...

77 FR 65691 - HIT Standards Committee Advisory Meeting; Notice of Meeting

Science.gov (United States)

2012-10-30

... DEPARTMENT OF HEALTH AND HUMAN SERVICES HIT Standards Committee Advisory Meeting; Notice of... public. Name of Committee: HIT Standards Committee. General Function of the Committee: To provide... developed by the HIT Policy Committee. Date and Time: The meeting will be held on November 13, 2012, from 9...

77 FR 50690 - HIT Standards Committee Advisory Meeting; Notice of Meeting

Science.gov (United States)

2012-08-22

... DEPARTMENT OF HEALTH AND HUMAN SERVICES HIT Standards Committee Advisory Meeting; Notice of... public. Name of Committee: HIT Standards Committee. General Function of the Committee: To provide... developed by the HIT Policy Committee. Date and Time: The meeting will be held on September 19, 2012, from 9...

76 FR 55913 - HIT Standards Committee Advisory Meeting; Notice of Meeting

Science.gov (United States)

2011-09-09

... DEPARTMENT OF HEALTH AND HUMAN SERVICES HIT Standards Committee Advisory Meeting; Notice of... public. Name of Committee: HIT Standards Committee. General Function of the Committee: to provide... developed by the HIT Policy Committee. Date and Time: The meeting will be held virtually on October 21, 2011...

77 FR 65690 - HIT Standards Committee Advisory Meeting; Notice of Meeting

Science.gov (United States)

2012-10-30

... DEPARTMENT OF HEALTH AND HUMAN SERVICES HIT Standards Committee Advisory Meeting; Notice of... public. Name of Committee: HIT Standards Committee. General Function of the Committee: To provide... developed by the HIT Policy Committee. Date and Time: The meeting will be held on December 19, 2012, from 9...

CMS MANAGEMENT MEETINGS

CERN Multimedia

2010-01-01

The Agendas and Minutes of the Management Board meetings are accessible to CMS members at: http://indico.cern.ch/categoryDisplay.py?categId=223 The Agendas and Minutes of the Collaboration Board meetings are accessible to CMS members at: http://indico.cern.ch/categoryDisplay.py?categId=174

Feline genetics: clinical applications and genetic testing.

Science.gov (United States)

Lyons, Leslie A

2010-11-01

DNA testing for domestic cat diseases and appearance traits is a rapidly growing asset for veterinary medicine. Approximately 33 genes contain 50 mutations that cause feline health problems or alterations in the cat's appearance. A variety of commercial laboratories can now perform cat genetic diagnostics, allowing both the veterinary clinician and the private owner to obtain DNA test results. DNA is easily obtained from a cat via a buccal swab with a standard cotton bud or cytological brush, allowing DNA samples to be easily sent to any laboratory in the world. The DNA test results identify carriers of the traits, predict the incidence of traits from breeding programs, and influence medical prognoses and treatments. An overall goal of identifying these genetic mutations is the correction of the defect via gene therapies and designer drug therapies. Thus, genetic testing is an effective preventative medicine and a potential ultimate cure. However, genetic diagnostic tests may still be novel for many veterinary practitioners and their application in the clinical setting needs to have the same scrutiny as any other diagnostic procedure. This article will review the genetic tests for the domestic cat, potential sources of error for genetic testing, and the pros and cons of DNA results in veterinary medicine. Highlighted are genetic tests specific to the individual cat, which are a part of the cat's internal genome. Copyright © 2010 Elsevier Inc. All rights reserved.

Public meetings

CERN Multimedia

Staff Association

2014-01-01

  Public meetings : Come and talk about your future employment conditions !   The Staff Association will come and present the results of our survey on the 2015 five-yearly review. Following the survey, the topics discussed, will be contract policy, recognition of merit (MARS), working time arrangements and family policy. After each meeting and around a cup of coffee or tea you will be able to continue the discussions. Do not hesitate to join us, the five-yearly review, it is with YOU!

77 FR 16035 - HIT Standards Committee Advisory Meeting; Notice of Meeting

Science.gov (United States)

2012-03-19

... DEPARTMENT OF HEALTH AND HUMAN SERVICES HIT Standards Committee Advisory Meeting; Notice of... public. Name of Committee: HIT Standards Committee. General Function of the Committee: to provide... developed by the HIT Policy Committee. Date and Time: The meeting will be held on March 27, 2012, from 9 a.m...

76 FR 79684 - HIT Standards Committee Advisory Meeting; Notice of Meeting

Science.gov (United States)

2011-12-22

... DEPARTMENT OF HEALTH AND HUMAN SERVICES HIT Standards Committee Advisory Meeting; Notice of... public. Name of Committee: HIT Standards Committee. General Function of the Committee: to provide... developed by the HIT Policy Committee. Date and Time: The meeting will be held on January 25, 2012, from 9 a...

77 FR 15760 - HIT Standards Committee Advisory Meeting; Notice of Meeting

Science.gov (United States)

2012-03-16

... DEPARTMENT OF HEALTH AND HUMAN SERVICES HIT Standards Committee Advisory Meeting; Notice of... public. Name of Committee: HIT Standards Committee. General Function of the Committee: to provide... developed by the HIT Policy Committee. Date and Time: The meeting will be held on April 18, 2012, from 9 a.m...

76 FR 14976 - HIT Standards Committee Advisory Meeting; Notice of Meeting

Science.gov (United States)

2011-03-18

... DEPARTMENT OF HEALTH AND HUMAN SERVICES HIT Standards Committee Advisory Meeting; Notice of... public. Name of Committee: HIT Standards Committee. General Function of the Committee: To provide... developed by the HIT Policy Committee. Date and Time: The meeting will be held on April 20, 2011, from 9 a.m...

76 FR 39109 - HIT Standards Committee Advisory Meeting; Notice of Meeting

Science.gov (United States)

2011-07-05

... DEPARTMENT OF HEALTH AND HUMAN SERVICES HIT Standards Committee Advisory Meeting; Notice of... public. Name of Committee: HIT Standards Committee. General Function of the Committee: to provide... developed by the HIT Policy Committee. Date and Time: The meeting will be held on July 20, 2011, from 9 a.m...

76 FR 28782 - HIT Standards Committee Advisory Meeting; Notice of Meeting

Science.gov (United States)

2011-05-18

... DEPARTMENT OF HEALTH AND HUMAN SERVICES HIT Standards Committee Advisory Meeting; Notice of... public. Name of Committee: HIT Standards Committee. General Function of the Committee: To provide... developed by the HIT Policy Committee. Date and Time: The meeting will be held on June 22, 2011, from 9 a.m...

77 FR 27459 - HIT Standards Committee Advisory Meeting; Notice of Meeting

Science.gov (United States)

2012-05-10

... DEPARTMENT OF HEALTH AND HUMAN SERVICES HIT Standards Committee Advisory Meeting; Notice of... public. Name of Committee: HIT Standards Committee. General Function of the Committee: To provide... developed by the HIT Policy Committee. Date and Time: The meeting will be held on June 20, 2012, from 9 a.m...

77 FR 37408 - HIT Standards Committee Advisory Meeting; Notice of Meeting

Science.gov (United States)

2012-06-21

... DEPARTMENT OF HEALTH AND HUMAN SERVICES HIT Standards Committee Advisory Meeting; Notice of... be open to the public. Name of Committee: HIT Standards Committee. General Function of the Committee... with policies developed by the HIT Policy Committee. Date and Time: The meeting will be held on July 19...

77 FR 22787 - HIT Standards Committee Advisory Meeting; Notice of Meeting

Science.gov (United States)

2012-04-17

... DEPARTMENT OF HEALTH AND HUMAN SERVICES HIT Standards Committee Advisory Meeting; Notice of... public. Name of Committee: HIT Standards Committee. General Function of the Committee: to provide... developed by the HIT Policy Committee. Date and Time: The meeting will be held on May 24, 2012, from 9 a.m...

76 FR 22396 - HIT Standards Committee Advisory Meeting; Notice of Meeting

Science.gov (United States)

2011-04-21

... DEPARTMENT OF HEALTH AND HUMAN SERVICES HIT Standards Committee Advisory Meeting; Notice of... public. Name of Committee: HIT Standards Committee. General Function of the Committee: to provide... developed by the HIT Policy Committee. Date and Time: The meeting will be held on May 18, 2011, from 9 a.m...

77 FR 60438 - HIT Standards Committee Advisory Meeting; Notice of Meeting

Science.gov (United States)

2012-10-03

... DEPARTMENT OF HEALTH AND HUMAN SERVICES HIT Standards Committee Advisory Meeting; Notice of... public. Name of Committee: HIT Standards Committee. General Function of the Committee: To provide... developed by the HIT Policy Committee. Date and Time: The meeting will be held on October 17, 2012, from 9 a...

76 FR 9783 - HIT Standards Committee Advisory Meeting; Notice of Meeting

Science.gov (United States)

2011-02-22

... DEPARTMENT OF HEALTH AND HUMAN SERVICES HIT Standards Committee Advisory Meeting; Notice of... public. Name of Committee: HIT Standards Committee. General Function of the Committee: To provide... developed by the HIT Policy Committee. Date and Time: The meeting will be held on March 29, 2011, from 9 a.m...

77 FR 45353 - HIT Standards Committee Advisory Meeting; Notice of Meeting

Science.gov (United States)

2012-07-31

... DEPARTMENT OF HEALTH AND HUMAN SERVICES HIT Standards Committee Advisory Meeting; Notice of... public. Name of Committee: HIT Standards Committee. General Function of the Committee: To provide... developed by the HIT Policy Committee. Date and Time: The meeting will be held on August 15, 2012, from 9:00...

78 FR 32295 - Commission Meeting

Science.gov (United States)

2013-05-29

... SUSQUEHANNA RIVER BASIN COMMISSION Commission Meeting AGENCY: Susquehanna River Basin Commission. ACTION: Notice. SUMMARY: The Susquehanna River Basin Commission will hold its regular business meeting on... business meeting are contained in the Supplementary Information section of this notice. DATES: June 20...

77 FR 10599 - Commission Meeting

Science.gov (United States)

2012-02-22

... SUSQUEHANNA RIVER BASIN COMMISSION Commission Meeting AGENCY: Susquehanna River Basin Commission. ACTION: Notice. SUMMARY: The Susquehanna River Basin Commission will hold its regular business meeting on... business meeting are contained in the Supplementary Information section of this notice. DATES: March 15...

78 FR 12412 - Commission Meeting

Science.gov (United States)

2013-02-22

... SUSQUEHANNA RIVER BASIN COMMISSION Commission Meeting AGENCY: Susquehanna River Basin Commission. ACTION: Notice. SUMMARY: The Susquehanna River Basin Commission will hold its regular business meeting on... business meeting are contained in the Supplementary Information section of this notice. DATES: March 21...

78 FR 52601 - Commission Meeting

Science.gov (United States)

2013-08-23

... SUSQUEHANNA RIVER BASIN COMMISSION Commission Meeting AGENCY: Susquehanna River Basin Commission. ACTION: Notice. SUMMARY: The Susquehanna River Basin Commission will hold its regular business meeting on... meeting are contained in the Supplementary Information section of this notice. DATES: September 19, 2013...

77 FR 70204 - Commission Meeting

Science.gov (United States)

2012-11-23

... SUSQUEHANNA RIVER BASIN COMMISSION Commission Meeting AGENCY: Susquehanna River Basin Commission. ACTION: Notice. SUMMARY: The Susquehanna River Basin Commission will hold its regular business meeting on... meeting are contained in the SUPPLEMENTARY INFORMATION section of this notice. DATES: December 14, 2012...

78 FR 69517 - Commission Meeting

Science.gov (United States)

2013-11-19

... SUSQUEHANNA RIVER BASIN COMMISSION Commission Meeting AGENCY: Susquehanna River Basin Commission. ACTION: Notice. SUMMARY: The Susquehanna River Basin Commission will hold its regular business meeting on... meeting are contained in the Supplementary Information section of this notice. DATES: December 12, 2013...

77 FR 52106 - Commission Meeting

Science.gov (United States)

2012-08-28

... SUSQUEHANNA RIVER BASIN COMMISSION Commission Meeting AGENCY: Susquehanna River Basin Commission. ACTION: Notice. SUMMARY: The Susquehanna River Basin Commission will hold its regular business meeting on... business meeting are contained in the Supplementary Information section of this notice. DATES: September 20...

CMS MANAGEMENT MEETINGS

CERN Multimedia

The Agendas and Minutes of the Management Board meetings are accessible to CMS members at: http://indico.cern.ch/categoryDisplay.py?categId=223  The Agendas and Minutes of the Collaboration Board meetings are accessible to CMS members at: http://indico.cern.ch/categoryDisplay.py?categId=174 

ACCU Meeting

CERN Document Server

Chris Onions

2005-01-01

DRAFT Agenda for the meeting to be held on Wednesday 7 December 2005 At 9:15 a.m. in room 60-6-002 Chairman's remarks Adoption of the agenda Minutes of the previous meeting Matters arising News from the CERN Management Closure of computer accounts upon CERN contract expiry Reports from ACCU representatives on other committees Users' Office news Election of ACCU Chair Any Other Business Agenda for the next meeting Anyone wishing to raise any points under item 10 is invited to send them to the Chairman in writing or by e-mail to Christopher.Onions@cern.ch Chris Onions (Secretary) ACCU is the forum for discussion between the CERN Management and the representatives of CERN Users to review the practical means taken by CERN for the work of Users of the Laboratory. The User Representatives to ACCU are (CERN internal telephone numbers in brackets). Austria W. Adam (71661) Belgium G. Wilquet (74664) Bulgaria Czech Republic P. Závada (75877) Denmark J.B. Hansen (75941) ...

ACCU Meeting

CERN Multimedia

Chris Onions

2005-01-01

DRAFT Agenda for the meeting to be held on Wednesday 8 June 2005 At 9:15 a.m. in room 60-6-002 Chairman's remarks Adoption of the agenda Minutes of the previous meeting Matters arising News from the CERN Management Logistics at CERN Open Access Publishing Reports from ACCU representatives on other committees Users' Office news Any Other Business Agenda for the next meeting Anyone wishing to raise any points under item 10 is invited to send them to the Chairman in writing or by e-mail to Christopher.Onions@cern.ch Chris Onions (Secretary) ACCU is the forum for discussion between the CERN Management and the representatives of CERN Users to review the practical means taken by CERN for the work of Users of the Laboratory. The User Representatives to ACCU are (CERN internal telephone numbers in brackets): Austria W. Adam (71661) Belgium G. Wilquet (74664) Bulgaria R. Tsenov (79573) Czech Republic P. Závada (75877) Denmark J.B. Hansen (75941) Finland K. Lassila-Perini ...

ACCU Meeting

CERN Multimedia

Chris Onions

2005-01-01

DRAFT Agenda for the meeting to be held on Wednesday 9 March 2005 At 9:15 a.m. in room 160-1-009 Chairman's remarks Adoption of the agenda Minutes of the previous meeting Matters arising News from the CERN Management Purchasing procedures at CERN Reports from ACCU representatives on other committees Users' Office news CERN Clubs Any Other Business Agenda for the next meeting Anyone wishing to raise any points under item 10 is invited to send them to the Chairman in writing or by e-mail to Christopher.Onions@cern.ch Chris Onions (Secretary) ACCU is the forum for discussion between the CERN Management and the representatives of CERN Users to review the practical means taken by CERN for the work of Users of the Laboratory. The User Representatives to ACCU are (CERN internal telephone numbers in brackets): Austria W. Adam (71661) Belgium G. Wilquet (74664) Bulgaria R. Tsenov (79573) Czech Republic P. Závada (75877) Denmark J.B. Hansen (75941) Finland K. Las...

ACCU MEETING

CERN Multimedia

PH Department

2008-01-01

DRAFT Agenda for the meeting to be heldon Wednesday 5 March 2008 At 9:15 a.m. in room 60-6-002 Chairman’s remarks Adoption of the agenda Minutes of the previous meeting Matters arising News from the CERN Management An update on Safety at CERN The CERN Ombudsperson proposal Childcare initiative Reports from ACCU representatives on other committees Users’ Office news Any Other Business Agenda for the next meeting Anyone wishing to raise any points under item 11 is invited to send them to the Chairman in writing or by e-mail to mailto:Christopher.Onions@cern.ch Chris Onions (Secretary) ACCU is the forum for discussion between the CERN Management and the representatives of CERN Users to review the practical means taken by CERN for the work of Users of the Laboratory. The User Representatives to ACCU are (CERN internal telephone numbers in brackets): Austria W. Adam (71661) BelgiumnC. Vander Velde (71539) Bulgaria Czech Republic P. Závada (75877) Denm...

ACCU MEETING

CERN Multimedia

2006-01-01

DRAFT Agenda of the meeting to be held on Wednesday 6 September 2006 at 9:15 a.m. in Room 60-6-002 Chairman's remarks Adoption of the agenda Minutes of the previous meeting Matters arising News from the CERN Management Report on Fellows and Associates Programme Overview of safety at CERN Reports from ACCU representatives on other committees Users' Office news Any Other Business Agenda for the next meeting Anyone wishing to raise any points under Item 10 is invited to send them to the Chairman in writing or by e-mail to Christopher.Onions@cern.ch Chris Onions (Secretary) ACCU is the forum for discussion between the CERN Management and the representatives of CERN Users to review the practical means taken by CERN for the work of Users of the Laboratory. The User Representatives to ACCU are (CERN internal telephone numbers in brackets): Austria W. Adam (71661) Belgium G. Wilquet (74664) Bulgaria Czech Republic P. Závada (75877) Denmark J.B. Hansen (75941) Finland K....

ACCU meeting

CERN Document Server

PH Department

2008-01-01

DRAFT Agenda for the meeting to be heldon Wednesday 5 March 2008 At 9:15 a.m. in room 60-6-002 Chairman’s remarks Adoption of the agenda Minutes of the previous meeting Matters arising News from the CERN Management An update on Safety at CERN The CERN Ombudsperson proposal Childcare initiative Reports from ACCU representatives on other committees Users’ Office news Any Other Business Agenda for the next meeting Anyone wishing to raise any points under item 11 is invited to send them to the Chairman in writing or by e-mail to mailto:Christopher.Onions@cern.ch Chris Onions (Secretary) ACCU is the forum for discussion between the CERN Management and the representatives of CERN Users to review the practical means taken by CERN for the work of Users of the Laboratory. The User Representatives to ACCU are (CERN internal telephone numbers in brackets): Austria W. Adam (71661) BelgiumnC. Vander Velde (71539) Bulgaria Czech Republic P. Závada (75877) Denm...

ACCU MEETING

CERN Document Server

PH Department

2008-01-01

DRAFT Agenda for the meeting to be held on Wednesday 10 September 2008 At 9:15 a.m. in Room 60-6-002 Chairman’s remarks Adoption of the agenda Minutes of the previous meeting Matters arising News from the CERN Management An update on Safety at CERN Reports from ACCU representatives on other committees Users’ Office news Any Other Business Agenda for the next meeting Anyone wishing to raise any points under item 9 is invited to send them to the Chairman in writing or by e-mail to mailto:Christopher.Onions@cern.ch Chris Onions (Secretary) ACCU is the forum for discussion between the CERN Management and the representatives of CERN Users to review the practical means taken by CERN for the work of Users of the Laboratory. The User Representatives to ACCU are (CERN internal telephone numbers in brackets): Austria, W. Adam (71661) Belgium, C. Vander Velde (71539) Bulgaria Czech Republic, P. Závada (75877) Denmark, J.B. Hansen (...

ACCU Meeting

CERN Document Server

2007-01-01

DRAFT Agenda for the meeting to be held on Wednesday 7 March 2007 at 9:15 a.m. in room 60-6-002 Chairman's remarks Adoption of the agenda Minutes of the previous meeting Matters arising News from the CERN Management Car-sharing pilot project Reports from ACCU representatives on other committees Users' Office news Any Other Business Agenda for the next meeting Anyone wishing to raise any points under item 9 is invited to send them to the Chairman in writing or by e-mail to Christopher.Onions@cern.ch Chris Onions (Secretary) ACCU is the forum for discussion between the CERN Management and the representatives of CERN Users to review the practical means taken by CERN for the work of Users of the Laboratory. The User Representatives to ACCU are (CERN internal telephone numbers in brackets): Austria W. Adam (71661) Belgium G. Wilquet (74664) Bulgaria Czech Republic P. Závada (75877) Denmark J.B. Hansen (75941) Finland K. Lassila-Perini (79354) France F. Kunne S. ...

ACCU Meeting

CERN Multimedia

PH Department

2008-01-01

DRAFT Agenda for the meeting to be held on Wednesday 11 June 2008 At 9:15 a.m. in room 60-6-002 Chairman’s remarks Adoption of the agenda Minutes of the previous meeting Matters arising News from the CERN Management An update on Safety at CERN Childcare initiative Reports from ACCU representatives on other committees Users’ Office news Any Other Business Agenda for the next meeting Anyone wishing to raise any points under item 10 is invited to send them to the Chairman in writing or by e-mail to mailto:Christopher.Onions@cern.ch Chris Onions (Secretary) ACCU is the forum for discussion between the CERN Management and the representatives of CERN Users to review the practical means taken by CERN for the work of Users of the Laboratory. The User Representatives to ACCU are (CERN internal telephone numbers in brackets): Austria - W. Adam (71661) Belgium - C. Vander Velde (71539) Bulgaria Czech Republic - P. Závada (75877) Denmark - J.B. Hansen...

ACCU MEETING

CERN Multimedia

Chris Onions

2001-01-01

DRAFT Agenda for the meeting to be held on Wednesday 7 March 2001 At 9:15 a.m. in the 6th floor Conference Room, Main Building Chairman's remarks Adoption of the agenda News from the CERN Management Minutes of the previous meeting Matters arising Video-conferencing/recording Fellows programme Operational Circular No. 6 EP Space management Update on Computing Issues Users' Office News Any Other Business Agenda for the next meeting Anyone wishing to raise any points under item 12 is invited to send them to the Secretary in writing via the CERN Users' Office or by e-mail to Christopher.Onions@cern.ch Chris Onions (Secretary)  ACCU is the forum for discussion between the CERN Management and the representatives of CERN Users to review the practical means taken by CERN for the work of Users of the Laboratory. The User Representatives to ACCU are (CERN internal telephone numbers in brackets): Austria W. Adam (71661) Belgium G. Wilquet (74664) Bulgaria R. Tzenov (77958) Czech Republic...

ACCU MEETING

CERN Multimedia

PH Department

2009-01-01

DRAFT Agenda for the meeting to be held on Wednesday 11 March 2009 At 9:15 a.m. in room 60-6-002 Chairman’s remarks Adoption of the agenda Minutes of the previous meeting Matters arising News from the CERN Management The CERN Press Office An update on Safety at CERN The Burotel project Reports from ACCU representatives on other committees Users’ Office news Any Other Business Agenda for the next meeting Anyone wishing to raise any points under item 11 is invited to send them to the Chairman in writing or by e-mail to mailto:Christopher.Onions@cern.ch Chris Onions (Secretary) ACCU is the forum for discussion between the CERN Management and the representatives of CERN Users to review the practical means taken by CERN for the work of Users of the Laboratory. The User Representatives to ACCU are (CERN internal telephone numbers in brackets): Austria G. Walzel () Belgium C. Vander Velde (71539) Bulgaria Czech Republic P. Závada (75877) Denmark...

ACCU MEETING

CERN Multimedia

PH Department

2010-01-01

DRAFT Agenda for the meeting to be held on Wednesday 10 March 2010 At 9:15 a.m. in room 60-6-002 Chairperson’s remarks Adoption of the agenda Minutes of the previous meeting Matters arising News from the CERN Management Report on services from GS department An update on Safety at CERN Reports from ACCU representatives on other committees Users’ Office news Any Other Business Agenda for the next meeting Anyone wishing to raise any points under item 10 is invited to send them to the Chairman in writing or by e-mail to Chris Onions (Secretary) ACCU is the forum for discussion between the CERN Management and the representatives of CERN Users to review the practical means taken by CERN for the work of Users of the Laboratory. The User Representatives on ACCU are (CERN internal telephone numbers in brackets): Austria G. Walzel (76592) Belgium C. Vander Velde (Chairperson) (71539) Bulgaria Czech Republic S. Nemecek (71144) ...

ACCU MEETING

CERN Multimedia

PH Department

2011-01-01

DRAFT Agenda for the meeting to be held on Wednesday 7 September 2011 at 9:15 a.m. in room 60-6-002   Chairperson's remarks Adoption of the agenda      Minutes of the previous meeting Matters arising       News from the CERN Management Report on services from GS department Report on new CHIS rules Users’ Office news Any Other Business Agenda for the next meeting Anyone wishing to raise any points under item 9 is invited to send them to the Chairperson in writing or by e-mail to Michael.Hauschild@cern.ch Michael Hauschild (Secretary) ACCU is the forum for discussion between the CERN Management and the representatives of CERN Users to review the practical means taken by CERN for the work of Users of the Laboratory. The User Representatives to ACCU are (CERN internal telephone numbers in brackets): Austria M. Jeitler (76307) Belgium C. Vander Velde (Chairperson)...

ACCU Meeting

CERN Multimedia

PH Department

2010-01-01

DRAFT Agenda for the meeting to be held on Wednesday 8 December 2010 at 9:15 a.m. in room 60-6-002 Chairperson's remarks Adoption of the agenda Minutes of the previous meeting Matters arising News from the CERN Management Report on services from GS department The CERN Ombuds The new account management system Crèche progress + Restaurants Reports from ACCU representatives on other committees Users’ Office news Any Other Business Agenda for the next meeting Anyone wishing to raise any points under item 12 is invited to send them to the Chairperson in writing or by e-mail to Michael.Hauschild@cern.ch   Michael Hauschild (Secretary) ACCU is the forum for discussion between the CERN Management and the representatives of CERN Users to review the practical means taken by CERN for the work of Users of the Laboratory. The User Representatives to ACCU are (CERN internal telephone numbers in brackets): ...

ACCU MEETING

CERN Multimedia

PH Department

2009-01-01

DRAFT Agenda for the meeting to be held on Wednesday 10 June 2009At 9:15 a.m. in room 60-6-002 Chairman’s remarks Adoption of the agenda Minutes of the previous meeting Matters arising News from the CERN Management CERN Social Services User services in GS Department An update on Safety at CERN Reports from ACCU representatives on other committees Users’ Office news Any Other Business Agenda for the next meeting Anyone wishing to raise any points under item 11 is invited to send them to the Chairman in writing or by e-mail to mailto:Christopher.Onions@cern.ch Chris Onions (Secretary) ACCU is the forum for discussion between the CERN Management and the representatives of CERN Users to review the practical means taken by CERN for the work of Users of the Laboratory. The User Representatives to ACCU are (CERN internal telephone numbers in brackets): Austria - G. Walzel (76592) Belgium - C. Vander Velde (71539) Bulgaria Czech Republic - P. Závada (7587...

ACCU MEETING

CERN Multimedia

PH Department

2010-01-01

DRAFT Agenda for the meeting to be held on Wednesday 8 September 2010 at 9:15 a.m. in Room 60-6-002 Chairperson’s remarks Adoption of the agenda Minutes of the previous meeting Matters arising News from the CERN Management Report on services from GS Department An update on Safety at CERN The CERN Summer Student program Bringing Library services to users Reports from ACCU representatives on other committees Users’ Office news Any Other Business Agenda for the next meeting Anyone wishing to raise any points under item 12 is invited to send them to the Chairperson in writing or by e-mail to Christopher.Onions@cern.ch Chris Onions (Secretary) ACCU is the forum for discussion between the CERN Management and the representatives of CERN Users to review the practical means taken by CERN for the work of Users of the Laboratory. The User Representatives to ACCU are (CERN internal telephone numbers in brackets): ...

ACCU Meeting

CERN Multimedia

Chris Onions

DRAFT Agenda for the meeting to be held on Wednesday 9 December 2009 At 9:15 a.m. in Room 60-6-002 Chairman’s remarks Adoption of the agenda Minutes of the previous meeting Matters arising News from the CERN Management Restaurant No. 1 extension An update on Safety at CERN Reports from ACCU representatives on other committees Users’ Office news Election of the ACCU Chair Any Other Business Agenda for the next meeting Anyone wishing to raise any points under item 11 is invited to send them to the Chairman in writing or by e-mail to Chris Onions (Secretary) ACCU is the forum for discussion between the CERN Management and the representatives of CERN Users to review the practical means taken by CERN for the work of Users of the Laboratory. The User Representatives to ACCU are (CERN internal telephone numbers in brackets): Austria G. Walzel (76592) Belgium C. Vander Velde (71539) Bulgaria Czech Republic P. Záv...

ACCU Meeting

CERN Multimedia

PH Department

2010-01-01

DRAFT Agenda for the meeting to be held on Wednesday 9 June 2010 At 9:15 a.m. in room 60-6-002 Chairperson’s remarks Adoption of the agenda Minutes of the previous meeting Matters arising News from the CERN Management Report on services from GS department CERN Global Network An update on Safety at CERN Reports from ACCU representatives on other committees Users’ Office news Any Other Business Agenda for the next meeting Anyone wishing to raise any points under item 11 is invited to send them to the Chairperson in writing or by e-mail to Christopher.Onions@cern.ch Chris Onions (Secretary) ACCU is the forum for discussion between the CERN Management and the representatives of CERN Users to review the practical means taken by CERN for the work of Users of the Laboratory. The User Representatives to ACCU are (CERN internal telephone numbers in brackets): Austria G. Walzel (76592) ...

[Current options of preimplantion genetic screening and preimplantation genetic diagnostics].

Science.gov (United States)

Šimečková, V

The aim of this work is to summarize the current knowledge about preimplantation genetic screening and diagnostics. A review article. Department of Gynecology and Obstetrics, District Hospital Šternberk, IVF Clinic, Olomouc. Preimplantation genetic testing is a complex of genetic and molecular cytogenetic examinations, which can help to detect abnormalities in embryos before transfer into the uterus of the mother. These specialized examinations are based on the latest findings in genetics and assisted reproduction. The preimplantation genetic testing is necessarily associated with a method of in vitro fertilization. It is performed on isolated blastomeres on the third day of embryo cultivation. Nowadays, it is preferred trophectoderm examination of cells from the five-day blastocysts. Generally speaking, after preimplantation genetic testing, we can select only embryos without genetic load to transfer into uterus. Preimplantation genetic testing is an important part of treatment of infertility. Complex diagnostics and treatment of infertile couples are increasingly influenced by the development and use of advanced genomic technologies. Further development and application of these modern methods require close cooperation between the field of assisted reproduction and clinical genetics.

Genetic Mapping

Science.gov (United States)

... greatly advanced genetics research. The improved quality of genetic data has reduced the time required to identify a ... cases, a matter of months or even weeks. Genetic mapping data generated by the HGP's laboratories is freely accessible ...

Hard Real-Time Task Scheduling in Cloud Computing Using an Adaptive Genetic Algorithm

Directory of Open Access Journals (Sweden)

Amjad Mahmood

2017-04-01

Full Text Available In the Infrastructure-as-a-Service cloud computing model, virtualized computing resources in the form of virtual machines are provided over the Internet. A user can rent an arbitrary number of computing resources to meet their requirements, making cloud computing an attractive choice for executing real-time tasks. Economical task allocation and scheduling on a set of leased virtual machines is an important problem in the cloud computing environment. This paper proposes a greedy and a genetic algorithm with an adaptive selection of suitable crossover and mutation operations (named as AGA to allocate and schedule real-time tasks with precedence constraint on heterogamous virtual machines. A comprehensive simulation study has been done to evaluate the performance of the proposed algorithms in terms of their solution quality and efficiency. The simulation results show that AGA outperforms the greedy algorithm and non-adaptive genetic algorithm in terms of solution quality.

77 FR 28420 - Commission Meeting

Science.gov (United States)

2012-05-14

... SUSQUEHANNA RIVER BASIN COMMISSION Commission Meeting AGENCY: Susquehanna River Basin Commission. ACTION: Notice. SUMMARY: The Susquehanna River Basin Commission will hold its regular business meeting on... meeting are contained in the Supplementary Information section of this notice. DATES: June 7, 2012, at 9...

4. Workshop - Measurement techniques of stationary and transient multiphase flow

International Nuclear Information System (INIS)

Prasser, H.M.

2001-05-01

In November 2000, the 4th Workshop on Measurement Techniques for Stationary and Transient Multiphase Flows took place in Rossendorf. Three previous workshops of this series were national meetings; this time participants from different countries took part. The programme comprised 14 oral presentations, 9 of which are included in these proceedings in full length. A special highlight of the meeting was the main lecture ''Ultrasonic doppler method for bubbly flow measurement'' of Professor Masanori Aritomi, Dr. Hiroshige Kikura and Dr. Yumiko Suzuki. The workshop again dealt with high-resolution phase distribution and phase velocity measurement techniques based on electrical conductivity, ultrasound, laser light and high-speed cinematography. A number of presentations were dedicated to the application of wire-mesh sensors developed by FZR for different applications used by the Technical Universities of Delft and Munich and the Tokyo Institute of Technology. (orig.)

75 FR 33306 - Notice of Meeting Location Change and Joint Meeting of FASAB and GASB

Science.gov (United States)

2010-06-11

... meeting is to discuss: --Measurement Attributes, --Reporting Model, --Cost Accounting, and --Governance... FEDERAL ACCOUNTING STANDARDS ADVISORY BOARD Notice of Meeting Location Change and Joint Meeting of FASAB and GASB AGENCY: Federal Accounting Standards Advisory Board. ACTION: Notice. Board Action...

78 FR 67201 - Sunshine Act Meeting

Science.gov (United States)

2013-11-08

... Institutional Advancement Committee will meet telephonically on November 22, 2013. The meeting will commence at... of the closed session meeting of the Institutional Advancement Committee. The transcript of any... 1973 Rehabilitation Act. Upon request, meeting notices and materials will be made available in...

Genetic Engineering and the Amelioration of Genetic Defect

Science.gov (United States)

Lederberg, Joshua

1970-01-01

Discusses the claims for a brave new world of genetic manipulation" and concludes that if we could agree upon applying genetic (or any other effective) remedies to global problems we probably would need no rescourse to them. Suggests that effective methods of preventing genetic disease are prevention of mutations and detection and…

Genetic studies of type 2 diabetes in South Asians: a systematic overview.

Science.gov (United States)

Chowdhury, Ritam; Narayan, Kabayam M Venkat; Zabetian, Azadeh; Raj, Suraja; Tabassum, Rubina

2014-01-01

Diabetes Mellitus, which affects 366 million people worldwide, is a leading cause of mortality, morbidity, and loss of quality of life. South Asians, comprising 24% of the world's population, suffer a large burden of type 2 diabetes. With intriguing risk phenotypes, unique environmental triggers, and potential genetic predisposition, South Asians offer a valuable resource for investigating the pathophysiology of type 2 diabetes. Genomics has proven its potential to underpin some of the etiology of type 2 diabetes by identifying a number of susceptibility genes, but such data are scarce and unclear in South Asians. We present a systematic review of studies on the genetic basis of type 2 diabetes or its complications in South Asians published between 1987-2012, and discuss the findings and limitations of the available data. Of the 91 eligible studies meeting our inclusion criteria, a vast majority included Indian populations, followed by a few in those of Pakistani origin, while other South Asian countries were generally under-represented. Though a large number of studies focused on the replication of findings from genome-wide association studies (GWAS) in European populations, a few studies explored new genes and pathways along with GWAS in South Asians and suggested the potential to unravel population- specific susceptibility genes in this population. We find encouraging improvements in study designs, sample sizes and the numbers of genetic variants investigated over the last five years, which reflect the existing capacity and scope for large-scale genetic studies in South Asians.

50. Brazilian congress on genetics. 50 years developing genetics. Abstracts

International Nuclear Information System (INIS)

2004-01-01

Use of radioisotopes and ionizing radiations in genetics is presented. Several aspects related to men, animals,plants and microorganisms are reported highlighting biological radiation effects, evolution, mutagenesis and genetic engineering. Genetic mapping, gene mutations, genetic diversity, DNA damages, plant cultivation and plant grow are studied as well

78 FR 73210 - Sunshine Act Meeting

Science.gov (United States)

2013-12-05

... Institutional Advancement Committee will meet telephonically on December 10, 2013. The meeting will commence at... will be made of the closed session meeting of the Institutional Advancement Committee. The transcript... Americans with Disabilities Act and Section 504 of the 1973 Rehabilitation Act. Upon request, meeting...

78 FR 12365 - Sunshine Act Meeting

Science.gov (United States)

2013-02-22

... Institutional Advancement Committee will meet telephonically on February 26, 2013. The meeting will commence at... made of the closed session of the Board and Institutional Advancement Committee meetings. The... Rehabilitation Act. Upon request, meeting notices and materials will be made available in alternative formats to...

Quantitative genetic analysis of anxiety trait in bipolar disorder.

Science.gov (United States)

Contreras, J; Hare, E; Chavarría, G; Raventós, H

2018-01-01

Bipolar disorder type I (BPI) affects approximately 1% of the world population. Although genetic influences on bipolar disorder are well established, identification of genes that predispose to the illness has been difficult. Most genetic studies are based on categorical diagnosis. One strategy to overcome this obstacle is the use of quantitative endophenotypes, as has been done for other medical disorders. We studied 619 individuals, 568 participants from 61 extended families and 51 unrelated healthy controls. The sample was 55% female and had a mean age of 43.25 (SD 13.90; range 18-78). Heritability and genetic correlation of the trait scale from the Anxiety State and Trait Inventory (STAI) was computed by using the general linear model (SOLAR package software). we observed that anxiety trait meets the following criteria for an endophenotype of bipolar disorder type I (BPI): 1) association with BPI (individuals with BPI showed the highest trait score (F = 15.20 [5,24], p = 0.009), 2) state-independence confirmed after conducting a test-retest in 321 subjects, 3) co-segregation within families 4) heritability of 0.70 (SE: 0.060), p = 2.33 × 10 -14 and 5) genetic correlation with BPI was 0.20, (SE = 0.17, p = 3.12 × 10 -5 ). Confounding factors such as comorbid disorders and pharmacological treatment could affect the clinical relationship between BPI and anxiety trait. Further research is needed to evaluate if anxiety traits are specially related to BPI in comparison with other traits such as anger, attention or response inhibition deficit, pathological impulsivity or low self-directedness. Anxiety trait is a heritable phenotype that follows a normal distribution when measured not only in subjects with BPI but also in unrelated healthy controls. It could be used as an endophenotype in BPI for the identification of genomic regions with susceptibility genes for this disorder. Published by Elsevier B.V.

Genetics educational needs in China: physicians' experience and knowledge of genetic testing.

Science.gov (United States)

Li, Jing; Xu, Tengda; Yashar, Beverly M

2015-09-01

The aims of this study were to explore the relationship between physicians' knowledge and utilization of genetic testing and to explore genetics educational needs in China. An anonymous survey about experience, attitudes, and knowledge of genetic testing was conducted among physicians affiliated with Peking Union Medical College Hospital during their annual health evaluation. A personal genetics knowledge score was developed and predictors of personal genetics knowledge score were evaluated. Sixty-four physicians (33% male) completed the survey. Fifty-eight percent of them had used genetic testing in their clinical practice. Using a 4-point scale, mean knowledge scores of six common genetic testing techniques ranged from 1.7 ± 0.9 to 2.4 ± 1.0, and the average personal genetics knowledge score was 2.1 ± 0.8. In regression analysis, significant predictors of higher personal genetics knowledge score were ordering of genetic testing, utilization of pedigrees, higher medical degree, and recent genetics training (P education. This study demonstrated a sizable gap between Chinese physicians' knowledge and utilization of genetic testing. Participants had high self-perceived genetics educational needs. Development of genetics educational platforms is both warranted and desired in China.Genet Med 17 9, 757-760.

Developing Foreign Language Communicative Competence for English Business Meetings Using Business Meeting Simulations

OpenAIRE

Mateja Dostal

2016-01-01

This article reports on the analysis of business meeting simulation data investigating the use of Business English (BE) in business meeting simulations at the Faculty of Economics, University of Ljubljana, Slovenia. The research explores the use of business meeting simulations in a higher education setting in order to bring into focus how patterns of linguistic interactions among BE students are structured, with and without a BE teacher’s corrective feedback. The findings provide possible sol...

Contemporary Genetics for Gender Researchers: Not Your Grandma's Genetics Anymore

Science.gov (United States)

Salk, Rachel H.; Hyde, Janet S.

2012-01-01

Over the past century, much of genetics was deterministic, and feminist researchers framed justified criticisms of genetics research. However, over the past two decades, genetics research has evolved remarkably and has moved far from earlier deterministic approaches. Our article provides a brief primer on modern genetics, emphasizing contemporary…

Particulate matter in the indoor air of classrooms—exploratory results from Munich and surrounding area

Science.gov (United States)

Fromme, H.; Twardella, D.; Dietrich, S.; Heitmann, D.; Schierl, R.; Liebl, B.; Rüden, H.

Numerous epidemiological studies have demonstrated the association between particle mass (PM) concentration in outside air and the occurrence of health related problems and/or diseases. However, much less is known about indoor PM concentrations and associated health risks. In particular, data are needed on air quality in schools, since children are assumed to be more vulnerable to health hazards and spend a large part of their time in classrooms. On this background, we evaluated indoor air quality in 64 schools in the city of Munich and a neighbouring district outside the city boundary. In winter 2004-2005 in 92 classrooms, and in summer 2005 in 75 classrooms, data on indoor air climate parameters (temperature, relative humidity), carbon dioxide (CO 2) and various dust particle fractions (PM 10, PM 2.5) were collected; for the latter both gravimetrical and continuous measurements by laser aerosol spectrometer (LAS) were implemented. In the summer period, the particle number concentration (PNC), was determined using a scanning mobility particle sizer (SMPS). Additionally, data on room and building characteristics were collected by use of a standardized form. Only data collected during teaching hours were considered in analysis. For continuously measured parameters the daily median was used to describe the exposure level in a classroom. The median indoor CO 2 concentration in a classroom was 1603 ppm in winter and 405 ppm in summer. With LAS in winter, median PM concentrations of 19.8 μg m -3 (PM 2.5) and 91.5 μg m -3 (PM 10) were observed, in summer PM concentrations were significantly reduced (median PM 2.5=12.7 μg m -3, median PM 10=64.9 μg m -3). PM 2.5 concentrations determined by the gravimetric method were in general higher (median in winter: 36.7 μg m -3, median in summer: 20.2 μg m -3) but correlated strongly with the LAS-measured results. In explorative analysis, we identified a significant increase of LAS-measured PM 2.5 by 1.7 μg m -3 per increase

Review of Meeting Objectives

International Nuclear Information System (INIS)

Braams, B.J.; Chung, H.-K.

2011-01-01

This is the 21st meeting of the International Atomic and Molecular Data Centres Network. The traditional DCN meeting objectives are: to exchange information about activities in the Centres and review progress; to coordinate work in the Centres; to assess priorities in data evaluation and data production; to make plans for specific evaluations; and to evaluate and revise procedures for collection and exchange of bibliographical and numerical data. All of these are objectives for the present meeting too. In addition to the presentations from DCN and prospective DCN members we have two participants from outside the field of fusion data: Dr N. Mason will tell us about coordination of the Virtual Atomic and Molecular Data Centre and Dr S. Simakov will describe the manner in which nuclear structure and cross-section database development is coordinated by our colleagues in the Nuclear Data Section. In the discussions on Thursday and Friday there are two topics that need special attention this year: the future of our bibliographical data compilation and ways in which we can strengthen data evaluation activities, all with emphasis on collision processes and plasma-material interaction. The first 3 Data Centre Network meetings were held in 1977, 1980 and 1982 and the reports of those meetings make interesting reading and can still provide inspiration for the present meeting. I show some excerpts in the presentation. In 1977 the emphasis was on the coordination of the bibliographical database, AMBDAS, and a collision data index, CIAMDA, as the initial activities of the Network and of the newly formed IAEA A+M Data Unit. In 1980 the central topic of discussion at the meeting shifted to the numerical database and to data evaluation. The Network recommended that numerical data be reviewed by a selected group of scientists and that no unevaluated numerical A+M collision data should be distributed by the IAEA. The report of the meeting in 1982 shows that the bibliographical

78 FR 59374 - Sunshine Act Meeting

Science.gov (United States)

2013-09-26

... Institutional Advancement Committee will meet telephonically on October 1, 2013. The meeting will commence at 4... meeting of the Institutional Advancement Committee. The transcript of any portion of the closed session... the 1973 Rehabilitation Act. Upon request, meeting notices and materials will be made available in...

78 FR 53480 - Sunshine Act Meeting

Science.gov (United States)

2013-08-29

... Institutional Advancement Committee will meet telephonically on September 3, 2013. The meeting will commence at... session meeting of the Institutional Advancement Committee. The transcript of any portion of the closed... Disabilities Act and Section 504 of the 1973 Rehabilitation Act. Upon request, meeting notices and materials...

78 FR 14839 - Sunshine Act Meeting

Science.gov (United States)

2013-03-07

... Institutional Advancement Committee will meet telephonically on March 12, 2013 and March 26, 2013. Each meeting... session meeting of the Institutional Advancement Committee. The transcript of any portion of the closed... Act and Section 504 of the 1973 Rehabilitation Act. Upon request, meeting notices and materials will...

78 FR 21978 - Sunshine Act Meeting

Science.gov (United States)

2013-04-12

... Institutional Advancement Committee will meet telephonically on April 23, 2013. The meeting will commence at 4... written transcript will be made of each closed session meeting of the Institutional Advancement Committee... the 1973 Rehabilitation Act. Upon request, meeting notices and materials will be made available in...

The meeting goer's lament.

Science.gov (United States)

Meyer, H

1980-10-22

Executives spend about 69% of their time in meeting with at least two other people, according to a recent study out of McGill University. In spite of this, participants do not consider this to be time used wisely and, according to the respondents, the problem seems to be growing worse. Despite the claims of some executives that government regulations or increased corporate complexity underlies the problem, society at large is viewed as the source of the change. Meyer asserts that all institutions have become less authoritarian and the trend away from command has left persuasion and consensus as the basis for corporate level decision-making. Although executives seem to agree that most time is wasted because participants fail to be succinct, the author argues that leaders could improve meetings by choosing the right participants, guiding them briskly through the agenda, and closing the meeting before it degenerates into a shouting match. The article suggests that chief executives are concluding that meeting skills can be learned. Most of the FORTUNE 500 companies have hired outside experts to teach these skills and some companies are building inhouse units for the same purpose. Since meetings have become an integral part of the business day, Meyer concluded that the goal of the executive should be to use the meeting time well.

J. Genet. classic 101

Indian Academy of Sciences (India)

Journal of Genetics, Vol. 85, No. 2, August 2006. 101. Page 2. J. Genet. classic. 102. Journal of Genetics, Vol. 85, No. 2, August 2006. Page 3. J. Genet. classic. Journal of Genetics, Vol. 85, No. 2, August 2006. 103. Page 4. J. Genet. classic. 104. Journal of Genetics, Vol. 85, No. 2, August 2006. Page 5. J. Genet. classic.

J. Genet. classic 37

Indian Academy of Sciences (India)

Unknown

Journal of Genetics, Vol. 84, No. 1, April 2005. 37. Page 2. J. Genet. classic. Journal of Genetics, Vol. 84, No. 1, April 2005. 38. Page 3. J. Genet. classic. Journal of Genetics, Vol. 84, No. 1, April 2005. 39. Page 4. J. Genet. classic. Journal of Genetics, Vol. 84, No. 1, April 2005. 40. Page 5. J. Genet. classic. Journal of ...

78 FR 78467 - Connected Vehicle Research Program Public Meeting; Notice of Public Meeting

Science.gov (United States)

2013-12-26

... connected vehicle technologies. The primary target audience for the meeting is State and local Departments... meeting is specifically focused for an audience that has followed connected vehicle research and is...

A Comparison of Telephone Genetic Counseling and In-Person Genetic Counseling from the Genetic Counselor's Perspective.

Science.gov (United States)

Burgess, Kelly R; Carmany, Erin P; Trepanier, Angela M

2016-02-01

Growing demand for and limited geographic access to genetic counseling services is increasing the need for alternative service delivery models (SDM) like telephone genetic counseling (TGC). Little research has been done on genetic counselors' perspectives of the practice of TGC. We created an anonymous online survey to assess whether telephone genetic counselors believed the tasks identified in the ABGC (American Board of Genetic Counseling) Practice Analysis were performed similarly or differently in TGC compared to in person genetic counseling (IPGC). If there were differences noted, we sought to determine the nature of the differences and if additional training might be needed to address them. Eighty eight genetic counselors with experience in TGC completed some or all of the survey. Respondents identified differences in 13 (14.8%) of the 88 tasks studied. The tasks identified as most different in TGC were: "establishing rapport through verbal and nonverbal interactions" (60.2%; 50/83 respondents identified the task as different), "recognizing factors affecting the counseling interaction" (47.8%; 32/67), "assessing client/family emotions, support, etc." (40.1%; 27/66) and "educating clients about basic genetic concepts" (35.6%; 26/73). A slight majority (53.8%; 35/65) felt additional training was needed to communicate information without visual aids and more effectively perform psychosocial assessments. In summary, although a majority of genetic counseling tasks are performed similarly between TGC and IPGC, TGC counselors recognize that specific training in the TGC model may be needed to address the key differences.

78 FR 8203 - Sunshine Act Meetings

Science.gov (United States)

2013-02-05

...: Commissioners' Conference Room, 11555 Rockville Pike, Rockville, Maryland. STATUS: Public and Closed. Week of... Meeting) (Contact: Ken Karwoski, 301-415-2752) This meeting will be webcast live at the web address--www... Uranium Recovery (Public Meeting) (Contact: Bill von Till, 301-415-0598) This meeting will be webcast live...