WorldWideScience

Sample records for generic anatomical models

  1. Building generic anatomical models using virtual model cutting and iterative registration

    Directory of Open Access Journals (Sweden)

    Hallgrímsson Benedikt

    2010-02-01

    Full Text Available Abstract Background Using 3D generic models to statistically analyze trends in biological structure changes is an important tool in morphometrics research. Therefore, 3D generic models built for a range of populations are in high demand. However, due to the complexity of biological structures and the limited views of them that medical images can offer, it is still an exceptionally difficult task to quickly and accurately create 3D generic models (a model is a 3D graphical representation of a biological structure based on medical image stacks (a stack is an ordered collection of 2D images. We show that the creation of a generic model that captures spatial information exploitable in statistical analyses is facilitated by coupling our generalized segmentation method to existing automatic image registration algorithms. Methods The method of creating generic 3D models consists of the following processing steps: (i scanning subjects to obtain image stacks; (ii creating individual 3D models from the stacks; (iii interactively extracting sub-volume by cutting each model to generate the sub-model of interest; (iv creating image stacks that contain only the information pertaining to the sub-models; (v iteratively registering the corresponding new 2D image stacks; (vi averaging the newly created sub-models based on intensity to produce the generic model from all the individual sub-models. Results After several registration procedures are applied to the image stacks, we can create averaged image stacks with sharp boundaries. The averaged 3D model created from those image stacks is very close to the average representation of the population. The image registration time varies depending on the image size and the desired accuracy of the registration. Both volumetric data and surface model for the generic 3D model are created at the final step. Conclusions Our method is very flexible and easy to use such that anyone can use image stacks to create models and

  2. Generic Market Models

    NARCIS (Netherlands)

    R. Pietersz (Raoul); M. van Regenmortel

    2005-01-01

    textabstractCurrently, there are two market models for valuation and risk management of interest rate derivatives, the LIBOR and swap market models. In this paper, we introduce arbitrage-free constant maturity swap (CMS) market models and generic market models featuring forward rates that span perio

  3. Reference Man anatomical model

    Energy Technology Data Exchange (ETDEWEB)

    Cristy, M.

    1994-10-01

    The 70-kg Standard Man or Reference Man has been used in physiological models since at least the 1920s to represent adult males. It came into use in radiation protection in the late 1940s and was developed extensively during the 1950s and used by the International Commission on Radiological Protection (ICRP) in its Publication 2 in 1959. The current Reference Man for Purposes of Radiation Protection is a monumental book published in 1975 by the ICRP as ICRP Publication 23. It has a wealth of information useful for radiation dosimetry, including anatomical and physiological data, gross and elemental composition of the body and organs and tissues of the body. The anatomical data includes specified reference values for an adult male and an adult female. Other reference values are primarily for the adult male. The anatomical data include much data on fetuses and children, although reference values are not established. There is an ICRP task group currently working on revising selected parts of the Reference Man document.

  4. Generic safety documentation model

    Energy Technology Data Exchange (ETDEWEB)

    Mahn, J.A.

    1994-04-01

    This document is intended to be a resource for preparers of safety documentation for Sandia National Laboratories, New Mexico facilities. It provides standardized discussions of some topics that are generic to most, if not all, Sandia/NM facilities safety documents. The material provides a ``core`` upon which to develop facility-specific safety documentation. The use of the information in this document will reduce the cost of safety document preparation and improve consistency of information.

  5. GENERIC model for multiphase systems

    NARCIS (Netherlands)

    Sagis, L.M.C.

    2010-01-01

    GENERIC is a nonequilibrium thermodynamic formalism in which the dynamic behavior of a system is described by a single compact equation involving two types of brackets: a Poisson bracket and a dissipative bracket. This formalism has proved to be a very powerful instrument to model the dynamic behavi

  6. Generic domain models in software engineering

    Science.gov (United States)

    Maiden, Neil

    1992-01-01

    This paper outlines three research directions related to domain-specific software development: (1) reuse of generic models for domain-specific software development; (2) empirical evidence to determine these generic models, namely elicitation of mental knowledge schema possessed by expert software developers; and (3) exploitation of generic domain models to assist modelling of specific applications. It focuses on knowledge acquisition for domain-specific software development, with emphasis on tool support for the most important phases of software development.

  7. Generic Graph Grammar: A Simple Grammar for Generic Procedural Modelling

    DEFF Research Database (Denmark)

    Christiansen, Asger Nyman; Bærentzen, Jakob Andreas

    2012-01-01

    in a directed cyclic graph. Furthermore, the basic productions are chosen such that Generic Graph Grammar seamlessly combines the capabilities of L-systems to imitate biological growth (to model trees, animals, etc.) and those of split grammars to design structured objects (chairs, houses, etc.). This results......Methods for procedural modelling tend to be designed either for organic objects, which are described well by skeletal structures, or for man-made objects, which are described well by surface primitives. Procedural methods, which allow for modelling of both kinds of objects, are few and usually...

  8. Network models in anatomical systems.

    Science.gov (United States)

    Esteve-Altava, Borja; Marugán-Lobón, Jesús; Botella, Héctor; Rasskin-Gutman, Diego

    2011-01-01

    Network theory has been extensively used to model the underlying structure of biological processes. From genetics to ecology, network thinking is changing our understanding of complex systems, specifically how their internal structure determines their overall behavior. Concepts such as hubs, scale-free or small-world networks, common in the complexity literature, are now used more and more in sociology, neurosciences, as well as other anthropological fields. Even though the use of network models is nowadays so widely applied, few attempts have been carried out to enrich our understanding in the classical morphological sciences such as in comparative anatomy or physical anthropology. The purpose of this article is to introduce the usage of network tools in morphology; specifically by building anatomical networks, dealing with the most common analyses and problems, and interpreting their outcome.

  9. Crystallization Kinetics within a Generic Modelling Framework

    DEFF Research Database (Denmark)

    Meisler, Kresten Troelstrup; von Solms, Nicolas; Gernaey, Krist

    2013-01-01

    An existing generic modelling framework has been expanded with tools for kinetic model analysis. The analysis of kinetics is carried out within the framework where kinetic constitutive models are collected, analysed and utilized for the simulation of crystallization operations. A modelling...... procedure is proposed to gain the information of crystallization operation kinetic model analysis and utilize this for faster evaluation of crystallization operations....

  10. Modelling of Generic Slung Load System

    DEFF Research Database (Denmark)

    Bisgaard, Morten; Bendtsen, Jan Dimon; La Cour-Harbo, Anders

    2006-01-01

    This paper presents the result of modelling and verification of a generic slung load system using a small-scale helicopter. The model is intended for use in simulation, pilot training, estimation, and control. The model is derived using a redundant coordinate formulation based on Gauss Principle ...

  11. Baldrige Theory into Practice: A Generic Model

    Science.gov (United States)

    Arif, Mohammed

    2007-01-01

    Purpose: The education system globally has moved from a push-based or producer-centric system to a pull-based or customer centric system. Malcolm Baldrige Quality Award (MBQA) model happens to be one of the latest additions to the pull based models. The purpose of this paper is to develop a generic framework for MBQA that can be used by…

  12. Baldrige Theory into Practice: A Generic Model

    Science.gov (United States)

    Arif, Mohammed

    2007-01-01

    Purpose: The education system globally has moved from a push-based or producer-centric system to a pull-based or customer centric system. Malcolm Baldrige Quality Award (MBQA) model happens to be one of the latest additions to the pull based models. The purpose of this paper is to develop a generic framework for MBQA that can be used by…

  13. Generic active appearance models revisited

    NARCIS (Netherlands)

    Tzimiropoulos, Georgios; Alabort-i-Medina, Joan; Zafeiriou, Stefanos; Pantic, Maja

    2012-01-01

    The proposed Active Orientation Models (AOMs) are gen- erative models of facial shape and appearance. Their main dierences with the well-known paradigm of Active Appearance Models (AAMs) are (i) they use a dierent statistical model of appearance, (ii) they are accompanied by a robust algorithm for m

  14. Towards Generic Models of Player Experience

    DEFF Research Database (Denmark)

    Shaker, Noor; Shaker, Mohammad; Abou-Zleikha, Mohamed

    2015-01-01

    -dependent and their applicability is usually limited to the system and the data used for model construction. Establishing models of user experience that are highly scalable while maintaing the performance constitutes an important research direction. In this paper, we propose generic models of user experience in the computer games...... further examine whether generic features of player be- haviour can be defined and used to boost the modelling per- formance. The accuracies obtained in both experiments in- dicate a promise for the proposed approach and suggest that game-independent player experience models can be built.......Context personalisation is a flourishing area of research with many applications. Context personalisation systems usually employ a user model to predict the appeal of the context to a particular user given a history of interactions. Most of the models used are context...

  15. Towards Generic Models of Player Experience

    DEFF Research Database (Denmark)

    Shaker, Noor; Shaker, Mohammad; Abou-Zleikha, Mohamed

    2015-01-01

    further examine whether generic features of player be- haviour can be defined and used to boost the modelling per- formance. The accuracies obtained in both experiments in- dicate a promise for the proposed approach and suggest that game-independent player experience models can be built.......-dependent and their applicability is usually limited to the system and the data used for model construction. Establishing models of user experience that are highly scalable while maintaing the performance constitutes an important research direction. In this paper, we propose generic models of user experience in the computer games...... domain. We employ two datasets collected from players in- teractions with two games from different genres where accu- rate models of players experience were previously built. We take the approach one step further by investigating the mod- elling mechanism ability to generalise over the two datasets. We...

  16. Generic Model Host System Design

    Energy Technology Data Exchange (ETDEWEB)

    Chu, Chungming; /SLAC; Wu, Juhao; /SLAC; Qiang, Ji; /LBL, Berkeley; Shen, Guobao; /Brookhaven

    2012-06-22

    There are many simulation codes for accelerator modelling; each one has some strength but not all. A platform which can host multiple modelling tools would be ideal for various purposes. The model platform along with infrastructure support can be used not only for online applications but also for offline purposes. Collaboration is formed for the effort of providing such a platform. In order to achieve such a platform, a set of common physics data structure has to be set. Application Programming Interface (API) for physics applications should also be defined within a model data provider. A preliminary platform design and prototype is discussed.

  17. The generic model of General Relativity

    Energy Technology Data Exchange (ETDEWEB)

    Tsamparlis, Michael, E-mail: mtsampa@phys.uoa.g [Department of Physics, Section Astrophysics Astronomy Mechanics, University of Athens, University of Athens, Zografos 15783, Athens (Greece)

    2009-10-01

    We develop a generic spacetime model in General Relativity from which all existing model results are produced under specific assumptions, depending on the case. We classify each type of possible assumption, especially the role of observers and that of symmetries, and discuss their role in the development of a model. We apply the results in a step by step approach to the case of a Bianchi I spacetime and a string fluid.

  18. Handbook of anatomical models for radiation dosimetry

    CERN Document Server

    Eckerman, Keith F

    2010-01-01

    Covering the history of human model development, this title presents the major anatomical and physical models that have been developed for human body radiation protection, diagnostic imaging, and nuclear medicine therapy. It explores how these models have evolved and the role that modern technologies have played in this development.

  19. A Generic Design Model for Evolutionary Algorithms

    Institute of Scientific and Technical Information of China (English)

    He Feng; Kang Li-shan; Chen Yu-ping

    2003-01-01

    A generic design model for evolutionary algo rithms is proposed in this paper. The model, which was described by UML in details, focuses on the key concepts and mechanisms in evolutionary algorithms. The model not only achieves separation of concerns and encapsulation of implementations by classification and abstraction of those concepts,it also has a flexible architecture due to the application of design patterns. As a result, the model is reusable, extendible,easy to understand, easy to use, and easy to test. A large number of experiments applying the model to solve many different problems adequately illustrate the generality and effectivity of the model.

  20. Modelling of Generic Slung Load System

    DEFF Research Database (Denmark)

    Bisgaard, Morten; Bendtsen, Jan Dimon; La Cour-Harbo, Anders

    2006-01-01

    of Least Constraint using the Udwadia-Kalaba equation and can be used to model all body to body slung load suspension types. The model gives an intuitive and easy-to-use way of modelling and simulating di erent slung load suspension types and it includes detection and response of wire slacking......This paper presents the result of modelling and verification of a generic slung load system using a small-scale helicopter. The model is intended for use in simulation, pilot training, estimation, and control. The model is derived using a redundant coordinate formulation based on Gauss Principle...

  1. Crystallization Kinetics within a Generic Modeling Framework

    DEFF Research Database (Denmark)

    Meisler, Kresten Troelstrup; von Solms, Nicolas; Gernaey, Krist V.

    2014-01-01

    to the modeling of various kinetic phenomena like nucleation, growth, agglomeration, and breakage are discussed in terms of model forms, model parameters, their availability and/or estimation, and their selection and application for specific crystallization operational scenarios under study. The advantages......A new and extended version of a generic modeling framework for analysis and design of crystallization operations is presented. The new features of this framework are described, with focus on development, implementation, identification, and analysis of crystallization kinetic models. Issues related...... of employing a well-structured model library for storage, use/reuse, and analysis of the kinetic models are highlighted. Examples illustrating the application of the modeling framework for kinetic model discrimination related to simulation of specific crystallization scenarios and for kinetic model parameter...

  2. Modeling of Generic Slung Load System

    DEFF Research Database (Denmark)

    Bisgaard, Morten; Bendtsen, Jan Dimon; la Cour-Harbo, Anders

    2009-01-01

    This paper presents the result of the modelling and verification of a generic slung load system using a small-scale helicopter. The model is intended for use in simulation, pilot training, estimation, and control. The model is derived using a redundant coordinate formulation based on Gauss......' Principle of Least Constraint using the Udwadia-Kalaba equation and can be used to model all body to body slung load suspension types. The model provides intuitive and easy-to-use means of modelling and simulating different slung load suspension types. It includes detection of, and response to, wire...... slackening and tightening as well as aerodynamic coupling between the helicopter and the load. Furthermore, it is shown how the model can be easily used for multi-lift systems either with multiple helicopters or multiple loads. A numerical stabilisation algorithm is introduced and finally the use...

  3. An anatomically oriented breast model for MRI

    Science.gov (United States)

    Kutra, Dominik; Bergtholdt, Martin; Sabczynski, Jörg; Dössel, Olaf; Buelow, Thomas

    2015-03-01

    Breast cancer is the most common cancer in women in the western world. In the breast cancer care-cycle, MRIis e.g. employed in lesion characterization and therapy assessment. Reading of a single three dimensional image or comparing a multitude of such images in a time series is a time consuming task. Radiological reporting is done manually by translating the spatial position of a finding in an image to a generic representation in the form of a breast diagram, outlining quadrants or clock positions. Currently, registration algorithms are employed to aid with the reading and interpretation of longitudinal studies by providing positional correspondence. To aid with the reporting of findings, knowledge about the breast anatomy has to be introduced to translate from patient specific positions to a generic representation. In our approach we fit a geometric primitive, the semi-super-ellipsoid to patient data. Anatomical knowledge is incorporated by fixing the tip of the super-ellipsoid to the mammilla position and constraining its center-point to a reference plane defined by landmarks on the sternum. A coordinate system is then constructed by linearly scaling the fitted super-ellipsoid, defining a unique set of parameters to each point in the image volume. By fitting such a coordinate system to a different image of the same patient, positional correspondence can be generated. We have validated our method on eight pairs of baseline and follow-up scans (16 breasts) that were acquired for the assessment of neo-adjuvant chemotherapy. On average, the location predicted and the actual location of manually set landmarks are within a distance of 5.6 mm. Our proposed method allows for automatic reporting simply by uniformly dividing the super-ellipsoid around its main axis.

  4. A Generic Middleware Model for Smart Home

    Directory of Open Access Journals (Sweden)

    Madhusudanan J.

    2014-07-01

    Full Text Available A Smart Home is an emerging technology, where the electronic devices are controlled automatically based on the occupants activities. The pervasive computing plays a vital role in the smart home environment, which provides the computer-based service to human beings anywhere and anytime. However, when discussing smart home of the future, related studies have focused on providing middleware. The middleware acts as a interface between human beings and the smart devices. In this paper, we have proposed a generic middleware model for smart home that enables interaction between human being and devices and also between various devices based on the context identified in the environment.

  5. Systematic identification of crystallization kinetics within a generic modelling framework

    DEFF Research Database (Denmark)

    Abdul Samad, Noor Asma Fazli Bin; Meisler, Kresten Troelstrup; Gernaey, Krist

    2012-01-01

    A systematic development of constitutive models within a generic modelling framework has been developed for use in design, analysis and simulation of crystallization operations. The framework contains a tool for model identification connected with a generic crystallizer modelling tool-box, a tool...

  6. Modeling generic aspects of ideal fibril formation

    CERN Document Server

    Michel, Denis

    2016-01-01

    Many different proteins self-aggregate into insoluble fibrils growing apically by reversible addition of elementary building blocks. But beyond this common principle, the modalities of fibril formation are very disparate, with various intermediate forms which can be reshuffled by minor modifications of physico-chemical conditions or amino-acid sequences. To bypass this complexity, the multifaceted phenomenon of fibril formation is reduced here to its most elementary principles defined for a linear prototype of fibril. Selected generic features, including nucleation, elongation and conformational recruitment, are modeled using minimalist hypotheses and tools, by separating equilibrium from kinetic aspects and in vitro from in vivo conditions. These reductionist approaches allow to bring out known and new rudiments, including the kinetic and equilibrium effects of nucleation, the dual influence of elongation on nucleation, the kinetic limitations on nucleation and fibril numbers and the accumulation of complexe...

  7. Computer-aided modeling framework – a generic modeling template

    DEFF Research Database (Denmark)

    Fedorova, Marina; Sin, Gürkan; Gani, Rafiqul

    This work focuses on the development of a computer-aided modeling framework. The framework is a knowledge-based system that is built on a generic modeling language and structured on workflows for different modeling tasks. The overall objective is to support model developers and users to generate...... and test models systematically, efficiently and reliably. In this way, development of products and processes can be made faster, cheaper and more efficient. In this contribution, as part of the framework, a generic modeling template for the systematic derivation of problem specific models is presented....... The application of the modeling template is highlighted with a case study related to the modeling of a catalytic membrane reactor coupling dehydrogenation of ethylbenzene with hydrogenation of nitrobenzene...

  8. Modeling generic aspects of ideal fibril formation

    Energy Technology Data Exchange (ETDEWEB)

    Michel, D., E-mail: denis.michel@live.fr [Universite de Rennes1-IRSET, Campus de Beaulieu Bat. 13, 35042 Rennes (France)

    2016-01-21

    Many different proteins self-aggregate into insoluble fibrils growing apically by reversible addition of elementary building blocks. But beyond this common principle, the modalities of fibril formation are very disparate, with various intermediate forms which can be reshuffled by minor modifications of physico-chemical conditions or amino-acid sequences. To bypass this complexity, the multifaceted phenomenon of fibril formation is reduced here to its most elementary principles defined for a linear prototype of fibril. Selected generic features, including nucleation, elongation, and conformational recruitment, are modeled using minimalist hypotheses and tools, by separating equilibrium from kinetic aspects and in vitro from in vivo conditions. These reductionist approaches allow to bring out known and new rudiments, including the kinetic and equilibrium effects of nucleation, the dual influence of elongation on nucleation, the kinetic limitations on nucleation and fibril numbers, and the accumulation of complexes in vivo by rescue from degradation. Overlooked aspects of these processes are also pointed: the exponential distribution of fibril lengths can be recovered using various models because it is attributable to randomness only. It is also suggested that the same term “critical concentration” is used for different things, involved in either nucleation or elongation.

  9. Parametric Anatomical Modeling: a method for modeling the anatomical layout of neurons and their projections.

    Science.gov (United States)

    Pyka, Martin; Klatt, Sebastian; Cheng, Sen

    2014-01-01

    Computational models of neural networks can be based on a variety of different parameters. These parameters include, for example, the 3d shape of neuron layers, the neurons' spatial projection patterns, spiking dynamics and neurotransmitter systems. While many well-developed approaches are available to model, for example, the spiking dynamics, there is a lack of approaches for modeling the anatomical layout of neurons and their projections. We present a new method, called Parametric Anatomical Modeling (PAM), to fill this gap. PAM can be used to derive network connectivities and conduction delays from anatomical data, such as the position and shape of the neuronal layers and the dendritic and axonal projection patterns. Within the PAM framework, several mapping techniques between layers can account for a large variety of connection properties between pre- and post-synaptic neuron layers. PAM is implemented as a Python tool and integrated in the 3d modeling software Blender. We demonstrate on a 3d model of the hippocampal formation how PAM can help reveal complex properties of the synaptic connectivity and conduction delays, properties that might be relevant to uncover the function of the hippocampus. Based on these analyses, two experimentally testable predictions arose: (i) the number of neurons and the spread of connections is heterogeneously distributed across the main anatomical axes, (ii) the distribution of connection lengths in CA3-CA1 differ qualitatively from those between DG-CA3 and CA3-CA3. Models created by PAM can also serve as an educational tool to visualize the 3d connectivity of brain regions. The low-dimensional, but yet biologically plausible, parameter space renders PAM suitable to analyse allometric and evolutionary factors in networks and to model the complexity of real networks with comparatively little effort.

  10. Implementation of IEC Generic Model Type 1A using RTDS

    DEFF Research Database (Denmark)

    Cha, Seung-Tae; Wu, Qiuwei; Zhao, Haoran

    2012-01-01

    This paper presents the implementation of the IEC generic model of Type 1 wind turbine generator (WTG) in the real time digital simulator (RTDS) environment. The model is based on the IEC 61400 TC88 under wind turbine working group’s standardization efforts are implemented. Several case studies...... have been carried out to verify the dynamic performance of the IEC generic Type 1 WTG model under both steady state and dynamic conditions. The case study results show that the IEC generic Type 1 WTG model can represent the relevant dynamic behaviour of wind power generation to ensure grid integration...

  11. Generic Sensor Modeling Using Pulse Method

    Science.gov (United States)

    Helder, Dennis L.; Choi, Taeyoung

    2005-01-01

    Recent development of high spatial resolution satellites such as IKONOS, Quickbird and Orbview enable observation of the Earth's surface with sub-meter resolution. Compared to the 30 meter resolution of Landsat 5 TM, the amount of information in the output image was dramatically increased. In this era of high spatial resolution, the estimation of spatial quality of images is gaining attention. Historically, the Modulation Transfer Function (MTF) concept has been used to estimate an imaging system's spatial quality. Sometimes classified by target shapes, various methods were developed in laboratory environment utilizing sinusoidal inputs, periodic bar patterns and narrow slits. On-orbit sensor MTF estimation was performed on 30-meter GSD Landsat4 Thematic Mapper (TM) data from the bridge pulse target as a pulse input . Because of a high resolution sensor s small Ground Sampling Distance (GSD), reasonably sized man-made edge, pulse, and impulse targets can be deployed on a uniform grassy area with accurate control of ground targets using tarps and convex mirrors. All the previous work cited calculated MTF without testing the MTF estimator's performance. In previous report, a numerical generic sensor model had been developed to simulate and improve the performance of on-orbit MTF estimating techniques. Results from the previous sensor modeling report that have been incorporated into standard MTF estimation work include Fermi edge detection and the newly developed 4th order modified Savitzky-Golay (MSG) interpolation technique. Noise sensitivity had been studied by performing simulations on known noise sources and a sensor model. Extensive investigation was done to characterize multi-resolution ground noise. Finally, angle simulation was tested by using synthetic pulse targets with angles from 2 to 15 degrees, several brightness levels, and different noise levels from both ground targets and imaging system. As a continuing research activity using the developed sensor

  12. YIP: Generic Environment Models (GEMs) for Agile Marine Autonomy

    Science.gov (United States)

    2013-09-30

    1 DISTRIBUTION STATEMENT A. Approved for public release; distribution is unlimited. YIP : Generic Environment Models (GEMs) for Agile Marine...2013 2. REPORT TYPE 3. DATES COVERED 00-00-2013 to 00-00-2013 4. TITLE AND SUBTITLE YIP : Generic Environment Models (GEMs) for Agile Marine...2010 ONR YIP Award Sponsor: Office of Naval Research Recipient: Fumin Zhang Institution: Georgia Institute of Technology Award: 2010 Lockheed

  13. Generic-Model-Based Description Scheme for MPEG-7

    Institute of Scientific and Technical Information of China (English)

    Deng Juan; Tan Hut; Chen Xin-meng

    2004-01-01

    We propose a new description scheme for MPEG7-: Generic-model-based Description Scheme to describe contents of audio, video, text and other sorts of multimedia.It uses a generic model as the description frame, which provides a simple but useful object-based structure. The main components of the description scheme are generic model, objects and object fcatures. The proposed description scheme is illustrated and exemplified by Extensible Markup Language.It aims at clarity and flexibility to support MPEG-7 applications such as query and edit. We demonstrate its feasibility and efficiency by presenting applications: Digital Broadcasting and Edit System (DEBS) and Non-linear Edit System (NLES) that already used the generic structure or will greatly benefit from it.

  14. Compositional design and reuse of a generic agent model

    NARCIS (Netherlands)

    Brazier, F.M.T.; Jonker, C.M.; Treur, J.

    2000-01-01

    This article introduces a formally specified design of a compositional generic agent model (GAM). This agent model abstracts from specific application domains; it provides a unified formal definition of a model for weak agenthood. It can be (re) used as a template or pattern for a large variety of a

  15. TOWARDS A GENERIC MODEL OF CATALYSIS Martin Grayson ...

    African Journals Online (AJOL)

    a

    We consider polarizabilities and hardness/softness parameters to see how ... The methodology presented here is simple, almost to the extreme, but contains within it tried ... approach is potentially exact it cannot be generic, because so much .... model molecule is in isolation, unless the program is explicitly told to model the.

  16. Defining Generic Architecture for Cloud Infrastructure as a Service model

    NARCIS (Netherlands)

    Demchenko, Y.; de Laat, C.

    2011-01-01

    Infrastructure as a Service (IaaS) is one of the provisioning models for Clouds as defined in the NIST Clouds definition. Although widely used, current IaaS implementations and solutions doesn’t have common and well defined architecture model. The paper attempts to define a generic architecture for

  17. Defining generic architecture for Cloud IaaS provisioning model

    NARCIS (Netherlands)

    Y. Demchenko; C. de Laat; A. Mavrin

    2011-01-01

    Infrastructure as a Service (IaaS) is one of the provisioning models for Clouds as defined in the NIST Clouds definition. Although widely used, current IaaS implementations and solutions doesn’t have common and well defined architecture model. The paper attempts to define a generic architecture for

  18. Generation of infant anatomical models for evaluating electromagnetic field exposures.

    Science.gov (United States)

    Li, Congsheng; Chen, Zhiye; Yang, Lei; Lv, Bin; Liu, Jianzhe; Varsier, Nadège; Hadjem, Abdelhamid; Wiart, Joe; Xie, Yi; Ma, Lin; Wu, Tongning

    2015-01-01

    Realistic anatomical modeling is essential in analyzing human exposure to electromagnetic fields. Infants have significant physical and anatomical differences compared with other age groups. However, few realistic infant models are available. In this work, we developed one 12-month-old male whole body model and one 17-month-old male head model from magnetic resonance images. The whole body and head models contained 28 and 30 tissues, respectively, at spatial resolution of 1 mm × 1 mm × 1 mm. Fewer identified tissues in the whole body model were a result of the low original image quality induced by the fast imaging sequence. The anatomical and physical parameters of the models were validated against findings in published literature (e.g., a maximum deviation as 18% in tissue mass was observed compared with the data from International Commission on Radiological Protection). Several typical exposure scenarios were realized for numerical simulation. Dosimetric comparison with various adult and child anatomical models was conducted. Significant differences in the physical and anatomical features between adult and child models demonstrated the importance of creating realistic infant models. Current safety guidelines for infant exposure to radiofrequency electromagnetic fields may not be conservative.

  19. Towards emotion modeling based on gaze dynamics in generic interfaces

    DEFF Research Database (Denmark)

    Vester-Christensen, Martin; Leimberg, Denis; Ersbøll, Bjarne Kjær

    2005-01-01

    Gaze detection can be a useful ingredient in generic human computer interfaces if current technical barriers are overcome. We discuss the feasibility of concurrent posture and eye-tracking in the context of single (low cost) camera imagery. The ingredients in the approach are posture and eye regi...... extraction based on active appearance modeling and eye tracking using a new fast and robust heuristic. The eye tracker is shown to perform well for low resolution image segments, hence, making it feasible to estimate gaze using a single generic camera.......Gaze detection can be a useful ingredient in generic human computer interfaces if current technical barriers are overcome. We discuss the feasibility of concurrent posture and eye-tracking in the context of single (low cost) camera imagery. The ingredients in the approach are posture and eye region...

  20. Towards emotion modeling based on gaze dynamics in generic interfaces

    DEFF Research Database (Denmark)

    Vester-Christensen, Martin; Leimberg, Denis; Ersbøll, Bjarne Kjær

    2005-01-01

    Gaze detection can be a useful ingredient in generic human computer interfaces if current technical barriers are overcome. We discuss the feasibility of concurrent posture and eye-tracking in the context of single (low cost) camera imagery. The ingredients in the approach are posture and eye regi...... extraction based on active appearance modeling and eye tracking using a new fast and robust heuristic. The eye tracker is shown to perform well for low resolution image segments, hence, making it feasible to estimate gaze using a single generic camera.......Gaze detection can be a useful ingredient in generic human computer interfaces if current technical barriers are overcome. We discuss the feasibility of concurrent posture and eye-tracking in the context of single (low cost) camera imagery. The ingredients in the approach are posture and eye region...

  1. Generic magnetohydrodynamic model at the Community Coordinated Modeling Center

    Science.gov (United States)

    Honkonen, I. J.; Rastaetter, L.; Glocer, A.

    2016-12-01

    The Community Coordinated Modeling Center (CCMC) at NASA Goddard Space Flight Center is a multi-agency partnership to enable, support and perform research and development for next-generation space science and space weather models. CCMC currently hosts nearly 100 numerical models and a cornerstone of this activity is the Runs on Request (RoR) system which allows anyone to request a model run and analyse/visualize the results via a web browser. CCMC is also active in the education community by organizing student research contests, heliophysics summer schools, and space weather forecaster training for students, government and industry representatives. Recently a generic magnetohydrodynamic (MHD) model was added to the CCMC RoR system which allows the study of a variety of fluid and plasma phenomena in one, two and three dimensions using a dynamic point-and-click web interface. For example students can experiment with the physics of fundamental wave modes of hydrodynamic and MHD theory, behavior of discontinuities and shocks as well as instabilities such as Kelvin-Helmholtz.Students can also use the model to experiments with numerical effects of models, i.e. how the process of discretizing a system of equations and solving them on a computer changes the solution. This can provide valuable background understanding e.g. for space weather forecasters on the effects of model resolution, numerical resistivity, etc. on the prediction.

  2. SIMPLEBOX: a generic multimedia fate evaluation model

    NARCIS (Netherlands)

    Meent D van de

    1993-01-01

    This document describes the technical details of the multimedia fate model SimpleBox, version 1.0 (930801). SimpleBox is a multimedia box model of what is commonly referred to as a "Mackay-type" model ; it assumes spatially homogeneous environmental compartments (air, water, suspended matter, aquati

  3. SIMPLEBOX: a generic multimedia fate evaluation model

    NARCIS (Netherlands)

    van de Meent D

    1993-01-01

    This document describes the technical details of the multimedia fate model SimpleBox, version 1.0 (930801). SimpleBox is a multimedia box model of what is commonly referred to as a "Mackay-type" model ; it assumes spatially homogeneous environmental compartments (air, water, suspended m

  4. Toward a generic model of trust for electronic commerce

    NARCIS (Netherlands)

    Tan, YH; Thoen, W

    2000-01-01

    The authors present a generic model of trust for electronic commerce consisting of two basic components, party trust and control trust, based on the concept that trust in a transaction with another party combines trust in the other parry and trust in the control mechanisms that ensure the successful

  5. Toward a generic model of trust for electronic commerce

    NARCIS (Netherlands)

    Tan, YH; Thoen, W

    2000-01-01

    The authors present a generic model of trust for electronic commerce consisting of two basic components, party trust and control trust, based on the concept that trust in a transaction with another party combines trust in the other parry and trust in the control mechanisms that ensure the successful

  6. Porter's Model of Generic Competitive Strategies

    OpenAIRE

    Orges Ormanidhi; Omer Stringa

    2008-01-01

    A firm's competitive behavior is an important topic for practitioners, theorists, and policy makers. Among the explanations of firms' behavior is Michael Porter's model. We have presented this model along with some alternative approaches: Structure-Conduct-Performance, the New Industrial Organization and Game Theory, the Resource-Based Perspective, and Market Process Economics. These approaches are discussed in terms of their relations, similarities, and differences relative to Porter's model...

  7. A generic model of dyadic social relationships.

    Science.gov (United States)

    Favre, Maroussia; Sornette, Didier

    2015-01-01

    We introduce a model of dyadic social interactions and establish its correspondence with relational models theory (RMT), a theory of human social relationships. RMT posits four elementary models of relationships governing human interactions, singly or in combination: Communal Sharing, Authority Ranking, Equality Matching, and Market Pricing. To these are added the limiting cases of asocial and null interactions, whereby people do not coordinate with reference to any shared principle. Our model is rooted in the observation that each individual in a dyadic interaction can do either the same thing as the other individual, a different thing or nothing at all. To represent these three possibilities, we consider two individuals that can each act in one out of three ways toward the other: perform a social action X or Y, or alternatively do nothing. We demonstrate that the relationships generated by this model aggregate into six exhaustive and disjoint categories. We propose that four of these categories match the four relational models, while the remaining two correspond to the asocial and null interactions defined in RMT. We generalize our results to the presence of N social actions. We infer that the four relational models form an exhaustive set of all possible dyadic relationships based on social coordination. Hence, we contribute to RMT by offering an answer to the question of why there could exist just four relational models. In addition, we discuss how to use our representation to analyze data sets of dyadic social interactions, and how social actions may be valued and matched by the agents.

  8. A generic model of dyadic social relationships.

    Directory of Open Access Journals (Sweden)

    Maroussia Favre

    Full Text Available We introduce a model of dyadic social interactions and establish its correspondence with relational models theory (RMT, a theory of human social relationships. RMT posits four elementary models of relationships governing human interactions, singly or in combination: Communal Sharing, Authority Ranking, Equality Matching, and Market Pricing. To these are added the limiting cases of asocial and null interactions, whereby people do not coordinate with reference to any shared principle. Our model is rooted in the observation that each individual in a dyadic interaction can do either the same thing as the other individual, a different thing or nothing at all. To represent these three possibilities, we consider two individuals that can each act in one out of three ways toward the other: perform a social action X or Y, or alternatively do nothing. We demonstrate that the relationships generated by this model aggregate into six exhaustive and disjoint categories. We propose that four of these categories match the four relational models, while the remaining two correspond to the asocial and null interactions defined in RMT. We generalize our results to the presence of N social actions. We infer that the four relational models form an exhaustive set of all possible dyadic relationships based on social coordination. Hence, we contribute to RMT by offering an answer to the question of why there could exist just four relational models. In addition, we discuss how to use our representation to analyze data sets of dyadic social interactions, and how social actions may be valued and matched by the agents.

  9. SUSY flavor structure of generic 5D supergravity models

    CERN Document Server

    Abe, Hiroyuki; Sakamura, Yutaka; Yamada, Yusuke

    2011-01-01

    We perform a comprehensive and systematic analysis of the SUSY flavor structure of generic 5D supergravity models on $S^1/Z_2$ with multiple $Z_2$-odd vector multiplets that generate multiple moduli. The SUSY flavor problem can be avoided due to contact terms in the 4D effective K\\"ahler potential peculiar to the multi-moduli case. A detailed phenomenological analysis is provided based on an illustrative model.

  10. Developing Generic Dynamic Models for the 2030 Eastern Interconnection Grid

    Energy Technology Data Exchange (ETDEWEB)

    Kou, Gefei [ORNL; Hadley, Stanton W [ORNL; Markham, Penn N [ORNL; Liu, Yilu [ORNL

    2013-12-01

    The Eastern Interconnection Planning Collaborative (EIPC) has built three major power flow cases for the 2030 Eastern Interconnection (EI) based on various levels of energy/environmental policy conditions, technology advances, and load growth. Using the power flow cases, this report documents the process of developing the generic 2030 dynamic models using typical dynamic parameters. The constructed model was validated indirectly using the synchronized phasor measurements by removing the wind generation temporarily.

  11. Additive Manufacturing of Anatomical Models from Computed Tomography Scan Data.

    Science.gov (United States)

    Gür, Y

    2014-12-01

    The purpose of the study presented here was to investigate the manufacturability of human anatomical models from Computed Tomography (CT) scan data via a 3D desktop printer which uses fused deposition modelling (FDM) technology. First, Digital Imaging and Communications in Medicine (DICOM) CT scan data were converted to 3D Standard Triangle Language (STL) format by using In Vaselius digital imaging program. Once this STL file is obtained, a 3D physical version of the anatomical model can be fabricated by a desktop 3D FDM printer. As a case study, a patient's skull CT scan data was considered, and a tangible version of the skull was manufactured by a 3D FDM desktop printer. During the 3D printing process, the skull was built using acrylonitrile-butadiene-styrene (ABS) co-polymer plastic. The printed model showed that the 3D FDM printing technology is able to fabricate anatomical models with high accuracy. As a result, the skull model can be used for preoperative surgical planning, medical training activities, implant design and simulation to show the potential of the FDM technology in medical field. It will also improve communication between medical stuff and patients. Current result indicates that a 3D desktop printer which uses FDM technology can be used to obtain accurate anatomical models.

  12. Application of Generic Disposal System Models

    Energy Technology Data Exchange (ETDEWEB)

    Mariner, Paul [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Hammond, Glenn Edward [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Sevougian, S. David [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Stein, Emily [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2015-11-01

    This report describes specific GDSA activities in fiscal year 2015 (FY2015) toward the development of the enhanced disposal system modeling and analysis capability for geologic disposal of nuclear waste. The GDSA framework employs the PFLOTRAN thermal-hydrologic-chemical multi-physics code (Hammond et al., 2011) and the Dakota uncertainty sampling and propagation code (Adams et al., 2013). Each code is designed for massively-parallel processing in a high-performance computing (HPC) environment. Multi-physics representations in PFLOTRAN are used to simulate various coupled processes including heat flow, fluid flow, waste dissolution, radionuclide release, radionuclide decay and ingrowth, precipitation and dissolution of secondary phases, and radionuclide transport through the engineered barriers and natural geologic barriers to a well location in an overlying or underlying aquifer. Dakota is used to generate sets of representative realizations and to analyze parameter sensitivity.

  13. Sensor Fault Tolerant Generic Model Control for Nonlinear Systems

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    A modified Strong Tracking Filter (STF) is used to develop a new approach to sensor fault tolerant control. Generic Model Control (GMC) is used to control the nonlinear process while the process runs normally because of its robust control performance. If a fault occurs in the sensor, a sensor bias vector is then introduced to the output equation of the process model. The sensor bias vector is estimated on-line during every control period using the STF. The estimated sensor bias vector is used to develop a fault detection mechanism to supervise the sensors. When a sensor fault occurs, the conventional GMC is switched to a fault tolerant control scheme, which is, in essence, a state estimation and output prediction based GMC. The laboratory experimental results on a three-tank system demonstrate the effectiveness of the proposed Sensor Fault Tolerant Generic Model Control (SFTGMC) approach.

  14. A Generic Evaluation Model for Semantic Web Services

    Science.gov (United States)

    Shafiq, Omair

    Semantic Web Services research has gained momentum over the last few Years and by now several realizations exist. They are being used in a number of industrial use-cases. Soon software developers will be expected to use this infrastructure to build their B2B applications requiring dynamic integration. However, there is still a lack of guidelines for the evaluation of tools developed to realize Semantic Web Services and applications built on top of them. In normal software engineering practice such guidelines can already be found for traditional component-based systems. Also some efforts are being made to build performance models for servicebased systems. Drawing on these related efforts in component-oriented and servicebased systems, we identified the need for a generic evaluation model for Semantic Web Services applicable to any realization. The generic evaluation model will help users and customers to orient their systems and solutions towards using Semantic Web Services. In this chapter, we have presented the requirements for the generic evaluation model for Semantic Web Services and further discussed the initial steps that we took to sketch such a model. Finally, we discuss related activities for evaluating semantic technologies.

  15. Modeling and Simulating Virtual Anatomical Humans

    NARCIS (Netherlands)

    Madehkhaksar, Forough; Luo, Zhiping; Pronost, Nicolas; Egges, Arjan

    2014-01-01

    This chapter presents human musculoskeletal modeling and simulation as a challenging field that lies between biomechanics and computer animation. One of the main goals of computer animation research is to develop algorithms and systems that produce plausible motion. On the other hand, the main chall

  16. From medical imaging data to 3D printed anatomical models.

    Science.gov (United States)

    Bücking, Thore M; Hill, Emma R; Robertson, James L; Maneas, Efthymios; Plumb, Andrew A; Nikitichev, Daniil I

    2017-01-01

    Anatomical models are important training and teaching tools in the clinical environment and are routinely used in medical imaging research. Advances in segmentation algorithms and increased availability of three-dimensional (3D) printers have made it possible to create cost-efficient patient-specific models without expert knowledge. We introduce a general workflow that can be used to convert volumetric medical imaging data (as generated by Computer Tomography (CT)) to 3D printed physical models. This process is broken up into three steps: image segmentation, mesh refinement and 3D printing. To lower the barrier to entry and provide the best options when aiming to 3D print an anatomical model from medical images, we provide an overview of relevant free and open-source image segmentation tools as well as 3D printing technologies. We demonstrate the utility of this streamlined workflow by creating models of ribs, liver, and lung using a Fused Deposition Modelling 3D printer.

  17. Generic simplified simulation model for DFIG with active crowbar

    Energy Technology Data Exchange (ETDEWEB)

    Buendia, Francisco Jimenez [Gamesa Innovation and Technology, Sarriguren, Navarra (Spain). Technology Dept.; Barrasa Gordo, Borja [Assystem Iberia, Bilbao, Vizcaya (Spain)

    2012-07-01

    Simplified models for transient stability studies are a general requirement for transmission system operators to wind turbine (WTG) manufacturers. Those models must represent the performance of the WTGs for transient stability studies, mainly voltage dips originated by short circuits in the electrical network. Those models are implemented in simulation software as PSS/E, DigSilent or PSLF. Those software platforms allow simulation of transients in large electrical networks with thousands of busses, generators and loads. The high complexity of the grid requires that the models inserted into the grid should be simplified in order to allow the simulations being executed as fast as possible. The development of a model which is simplified enough to be integrated in those complex grids and represent the performance of WTG is a challenge. The IEC TC88 working group has developed generic models for different types of generators, among others for WTGs using doubly fed induction generators (DFIG). This paper will focus in an extension of the models for DFIG WTGs developed in IEC in order to be able to represent the simplified model of DFIG with an active crowbar, which is required to withstand voltage dips without disconnecting from the grid. This paper improves current generic model of Type 3 for DFIG adding a simplified version of the generator including crowbar functionality and a simplified version of the crowbar firing. In addition, this simplified model is validated by correlation with voltage dip field test from a real wind turbine. (orig.)

  18. Brain anatomical structure segmentation by hybrid discriminative/generative models.

    Science.gov (United States)

    Tu, Z; Narr, K L; Dollar, P; Dinov, I; Thompson, P M; Toga, A W

    2008-04-01

    In this paper, a hybrid discriminative/generative model for brain anatomical structure segmentation is proposed. The learning aspect of the approach is emphasized. In the discriminative appearance models, various cues such as intensity and curvatures are combined to locally capture the complex appearances of different anatomical structures. A probabilistic boosting tree (PBT) framework is adopted to learn multiclass discriminative models that combine hundreds of features across different scales. On the generative model side, both global and local shape models are used to capture the shape information about each anatomical structure. The parameters to combine the discriminative appearance and generative shape models are also automatically learned. Thus, low-level and high-level information is learned and integrated in a hybrid model. Segmentations are obtained by minimizing an energy function associated with the proposed hybrid model. Finally, a grid-face structure is designed to explicitly represent the 3-D region topology. This representation handles an arbitrary number of regions and facilitates fast surface evolution. Our system was trained and tested on a set of 3-D magnetic resonance imaging (MRI) volumes and the results obtained are encouraging.

  19. A model for the generic alpha relaxation in viscous liquids

    DEFF Research Database (Denmark)

    Dyre, Jeppe

    2005-01-01

    . Rev. Lett., 86 (2001) 1271]. Assuming that long-wavelength fluctuations dominate the dynamics, a model for the dielectric alpha relaxation based on the simplest coupling between the density and dipole density fields is proposed here. The model, which is solved in second-order perturbation theory......Dielectric measurements on molecular liquids just above the glass transition indicate that alpha relaxation is characterized by a generic high-frequency loss varying as one over square root of frequency, whereas deviations from this come from one or more low-lying beta processes [Olsen et al., Phys...

  20. Generic phase coexistence in the totally asymmetric kinetic Ising model

    Science.gov (United States)

    Godrèche, Claude; Luck, Jean-Marc

    2017-07-01

    The physical analysis of generic phase coexistence in the North-East-Center Toom model was originally given by Bennett and Grinstein. The gist of their argument relies on the dynamics of interfaces and droplets. We revisit the same question for a specific totally asymmetric kinetic Ising model on the square lattice. This nonequilibrium model possesses the remarkable property that its stationary-state measure in the absence of a magnetic field coincides with that of the usual ferromagnetic Ising model. We use both analytical arguments and numerical simulations in order to make progress in the quantitative understanding of the phenomenon of generic phase coexistence. At zero temperature a mapping onto the TASEP allows an exact determination of the time-dependent shape of the ballistic interface sweeping a large square minority droplet of up or down spins. At finite temperature, measuring the mean lifetime of such a droplet allows an accurate measurement of its shrinking velocity v, which depends on temperature T and magnetic field h. In the absence of a magnetic field, v vanishes with an exponent Δ_v≈2.5+/-0.2 as the critical temperature T c is approached. At fixed temperature in the ordered phase, v vanishes at the phase-boundary fields +/- h_b(T) which mark the limits of the coexistence region. The latter fields vanish with an exponent Δ_h≈3.2+/-0.3 as T c is approached.

  1. DESIGN OF 3D MODEL OF CUSTOMIZED ANATOMICALLY ADJUSTED IMPLANTS

    OpenAIRE

    Miodrag Manić; Zoran Stamenković; Milorad Mitković; Miloš Stojković; Duncan E.T. Shephard

    2015-01-01

    Design and manufacturing of customized implants is a field that has been rapidly developing in recent years. This paper presents an originally developed method for designing a 3D model of customized anatomically adjusted implants. The method is based upon a CT scan of a bone fracture. A CT scan is used to generate a 3D bone model and a fracture model. Using these scans, an indicated location for placing the implant is recognized and the design of a 3D model of customized implants is made. Wit...

  2. Anatomical evaluation of CT-MRI combined femoral model

    Directory of Open Access Journals (Sweden)

    Kim Gyu-Ha

    2008-01-01

    Full Text Available Abstract Background Both CT and MRI are complementary to each other in that CT can produce a distinct contour of bones, and MRI can show the shape of both ligaments and bones. It will be ideal to build a CT-MRI combined model to take advantage of complementary information of each modality. This study evaluated the accuracy of the combined femoral model in terms of anatomical inspection. Methods Six normal porcine femora (180 ± 10 days, 3 lefts and 3 rights with ball markers were scanned by CT and MRI. The 3D/3D registration was performed by two methods, i.e. the landmark-based 3 points-to-3 points and the surface matching using the iterative closest point (ICP algorithm. The matching accuracy of the combined model was evaluated with statistical global deviation and locally measure anatomical contour-based deviation. Statistical analysis to assess any significant difference between accuracies of those two methods was performed using univariate repeated measures ANOVA with the Turkey post hoc test. Results This study revealed that the local 2D contour-based measurement of matching deviation was 0.5 ± 0.3 mm in the femoral condyle, and in the middle femoral shaft. The global 3D contour matching deviation of the landmark-based matching was 1.1 ± 0.3 mm, but local 2D contour deviation through anatomical inspection was much larger as much as 3.0 ± 1.8 mm. Conclusion Even with human-factor derived errors accumulated from segmentation of MRI images, and limited image quality, the matching accuracy of CT-&-MRI combined 3D models was 0.5 ± 0.3 mm in terms of local anatomical inspection.

  3. Generic solar photovoltaic system dynamic simulation model specification

    Energy Technology Data Exchange (ETDEWEB)

    Ellis, Abraham [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Behnke, Michael Robert [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Elliott, Ryan Thomas [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2013-10-01

    This document is intended to serve as a specification for generic solar photovoltaic (PV) system positive-sequence dynamic models to be implemented by software developers and approved by the WECC MVWG for use in bulk system dynamic simulations in accordance with NERC MOD standards. Two specific dynamic models are included in the scope of this document. The first, a Central Station PV System model, is intended to capture the most important dynamic characteristics of large scale (> 10 MW) PV systems with a central Point of Interconnection (POI) at the transmission level. The second, a Distributed PV System model, is intended to represent an aggregation of smaller, distribution-connected systems that comprise a portion of a composite load that might be modeled at a transmission load bus.

  4. A Generic Model to Exploit Urban Regulation Knowledge

    Directory of Open Access Journals (Sweden)

    Mickaël Brasebin

    2016-02-01

    Full Text Available The Right to Build is defined by textual elements that determine what an owner can build on a parcel. Such regulations contain elements that can influence the development of territories. Expressed through legal texts, their effects on the territory are difficult to assess because of the documents’ complexity and of the diversity of urban configurations. In this paper, we present a generic and extendable model to represent such  regulations. This model is based on (1 a representation of geographical concepts (attributes, features and relations mentioned in regulations and (2 rules formalized with Object Constraints Language (OCL. We also propose an implementation that allows the handling of formalized rules in order to check if a building configuration proposal respects urban regulations. Many applications are possible in order to assist in the conception of such regulations, land acquisition strategy or territorial evolution studies, in this article, we notably describe a future application dedicated to assist building permit surveyors.

  5. DESIGN OF 3D MODEL OF CUSTOMIZED ANATOMICALLY ADJUSTED IMPLANTS

    Directory of Open Access Journals (Sweden)

    Miodrag Manić

    2015-12-01

    Full Text Available Design and manufacturing of customized implants is a field that has been rapidly developing in recent years. This paper presents an originally developed method for designing a 3D model of customized anatomically adjusted implants. The method is based upon a CT scan of a bone fracture. A CT scan is used to generate a 3D bone model and a fracture model. Using these scans, an indicated location for placing the implant is recognized and the design of a 3D model of customized implants is made. With this method it is possible to design volumetric implants used for replacing a part of the bone or a plate type for fixation of a bone part. The sides of the implants, this one lying on the bone, are fully aligned with the anatomical shape of the bone surface which neighbors the fracture. The given model is designed for implants production utilizing any method, and it is ideal for 3D printing of implants.

  6. Implementation of IEC Generic Model Type 1 Wind Turbine Generators using RTDS

    DEFF Research Database (Denmark)

    Cha, Seung-Tae; Wu, Qiuwei; Zhao, Haoran

    are useful tools to evaluate the impact of the wind power on the power system stability. Thus, a strong stimulus exists for the development of a generic dynamic model in order to further investigate the dynamic response of WTG under grid disturbances. This paper presents the implementation of the IEC generic...... Type 1A and 1B WTG models in the real time digital simulator (RTDS) environment. Case studies have been carried out to verify the performance of the IEC generic Type 1 WTG model under both steady state and dynamic conditions. The case study results show that the IEC generic Type 1 WTG model can...

  7. Generic model for line-of-sight analysis and calibration

    Science.gov (United States)

    Afik, Zvika; Shammas, A.; Schwartz, Roni; Gal, Eli

    1991-04-01

    1ariy electrooptical (E'O) systems incorporate an inaging sensor and a Line of Sight (LOS) deflection mirror. At a higher system level, such as for fire control or mIssile homing applications, these sensors are required to neasure angular target position very accurately. This work presents ar approach that has been developed for the modeling and calibration of such electrooptical systems. Using a generic system which includes a mirror mounted on a twoaxis LOS steering unit and an imaging sensor, a description of the mathematical model of the system is given here. This model may be used for system performance analyses as well as for developing various algorithms for the calculation of target angular position. The system model uses a number of calibration parameters such as gimbal nonorthogonality and other assembly and production errors. These are obtained from laboratory measurement results via a mathematical calibration model. We explain how the calibration model is developed from the system model. The method shown here can significantly reduce the number of computations and the look-up-table capacity needed in an operational system, as well as reducing the extent of laboratory calibrations usually required.

  8. Creating a Generic Extended Enterprise Management Model using GERAM

    DEFF Research Database (Denmark)

    Larsen, Lars Bjørn; Kaas-Pedersen, Carsten; Vesterager, Johan

    1998-01-01

    The two main themes of the Globeman21 (Global Manufacturing in the 21st century) project are product life cycle management and extended enterprise management. This article focus on the later of these subjects and an illustration of the concept is given together with a discussion of the concept...... management model. By working with GERAM in relation to extended enterprise management it has been found that it provides a useful background for organising knowledge, experience and the activities within the project...... of virtual enterprises. Through the introduction of GERAM (Generalised Enterprise Reference Architecture and Methodology) an initial version of a basic framework for extended enterprise management is introduced. This basic framework is the first step towards the creation of a generic extended enterprise...

  9. A propositional representation model of anatomical and functional brain data.

    Science.gov (United States)

    Maturana, Pablo; Batrancourt, Bénédicte

    2011-01-01

    Networks can represent a large number of systems. Recent advances in the domain of networks have been transferred to the field of neuroscience. For example, the graph model has been used in neuroscience research as a methodological tool to examine brain networks organization, topology and complex dynamics, as well as a framework to test the structure-function hypothesis using neuroimaging data. In the current work we propose a graph-theoretical framework to represent anatomical, functional and neuropsychological assessment instruments information. On the one hand, interrelationships between anatomic elements constitute an anatomical graph. On the other hand, a functional graph contains several cognitive functions and their more elementary cognitive processes. Finally, the neuropsychological assessment instruments graph includes several neuropsychological tests and scales linked with their different sub-tests and variables. The two last graphs are connected by relations of type "explore" linking a particular instrument with the cognitive function it explores. We applied this framework to a sample of patients with focal brain damage. Each patient was related to: (i) the cerebral entities injured (assessed with structural neuroimaging data) and (ii) the neusopsychological assessment tests carried out (weight by performance). Our model offers a suitable platform to visualize patients' relevant information, facilitating the representation, standardization and sharing of clinical data. At the same time, the integration of a large number of patients in this framework will make possible to explore relations between anatomy (injured entities) and function (performance in different tests assessing different cognitive functions) and the use of neurocomputational tools for graph analysis may help diagnostic and contribute to the comprehension of neural bases of cognitive functions.

  10. Generic Modelling of Faecal Indicator Organism Concentrations in the UK

    Directory of Open Access Journals (Sweden)

    Carl M. Stapleton

    2011-06-01

    Full Text Available To meet European Water Framework Directive requirements, data are needed on faecal indicator organism (FIO concentrations in rivers to enable the more heavily polluted to be targeted for remedial action. Due to the paucity of FIO data for the UK, especially under high-flow hydrograph event conditions, there is an urgent need by the policy community for generic models that can accurately predict FIO concentrations, thus informing integrated catchment management programmes. This paper reports the development of regression models to predict base- and high-flow faecal coliform (FC and enterococci (EN concentrations for 153 monitoring points across 14 UK catchments, using land cover, population (human and livestock density and other variables that may affect FIO source strength, transport and die-off. Statistically significant models were developed for both FC and EN, with greater explained variance achieved in the high-flow models. Both land cover and, in particular, population variables are significant predictors of FIO concentrations, with r2 maxima for EN of 0.571 and 0.624, respectively. It is argued that the resulting models can be applied, with confidence, to other UK catchments, both to predict FIO concentrations in unmonitored watercourses and evaluate the likely impact of different land use/stocking level and human population change scenarios.

  11. A generic biogeochemical module for earth system models

    Directory of Open Access Journals (Sweden)

    Y. Fang

    2013-06-01

    Full Text Available Physical and biogeochemical processes regulate soil carbon dynamics and CO2 flux to and from the atmosphere, influencing global climate changes. Integration of these processes into earth system models (e.g. community land models – CLM, however, currently faces three major challenges: (1 extensive efforts are required to modify modeling structures and to rewrite computer programs to incorporate new or updated processes as new knowledge is being generated, (2 computational cost is prohibitively expensive to simulate biogeochemical processes in land models due to large variations in the rates of biogeochemical processes, and (3 various mathematical representations of biogeochemical processes exist to incorporate different aspects of fundamental mechanisms, but systematic evaluation of the different mathematical representations is difficult, if not impossible. To address these challenges, we propose a new computational framework to easily incorporate physical and biogeochemical processes into land models. The new framework consists of a new biogeochemical module with a generic algorithm and reaction database so that new and updated processes can be incorporated into land models without the need to manually set up the ordinary differential equations to be solved numerically. The reaction database consists of processes of nutrient flow through the terrestrial ecosystems in plants, litter and soil. This framework facilitates effective comparison studies of biogeochemical cycles in an ecosystem using different conceptual models under the same land modeling framework. The approach was first implemented in CLM and benchmarked against simulations from the original CLM-CN code. A case study was then provided to demonstrate the advantages of using the new approach to incorporate a phosphorus cycle into the CLM model. To our knowledge, the phosphorus-incorporated CLM is a new model that can be used to simulate phosphorus limitation on the productivity of

  12. Anatomically based lower limb nerve model for electrical stimulation

    Directory of Open Access Journals (Sweden)

    Soboleva Tanya K

    2007-12-01

    Full Text Available Abstract Background Functional Electrical Stimulation (FES is a technique that aims to rehabilitate or restore functionality of skeletal muscles using external electrical stimulation. Despite the success achieved within the field of FES, there are still a number of questions that remain unanswered. One way of providing input to the answers is through the use of computational models. Methods This paper describes the development of an anatomically based computer model of the motor neurons in the lower limb of the human leg and shows how it can be used to simulate electrical signal propagation from the beginning of the sciatic nerve to a skeletal muscle. One-dimensional cubic Hermite finite elements were used to represent the major portions of the lower limb nerves. These elements were fit to data that had been digitised using images from the Visible Man project. Nerves smaller than approximately 1 mm could not be seen in the images, and thus a tree-branching algorithm was used to connect the ends of the fitted nerve model to the respective skeletal muscle. To simulate electrical propagation, a previously published mammalian nerve model was implemented and solved on the anatomically based nerve mesh using a finite difference method. The grid points for the finite difference method were derived from the fitted finite element mesh. By adjusting the tree-branching algorithm, it is possible to represent different levels of motor-unit recruitment. Results To illustrate the process of a propagating nerve stimulus to a muscle in detail, the above method was applied to the nerve tree that connects to the human semitendinosus muscle. A conduction velocity of 89.8 m/s was obtained for a 15 μm diameter nerve fibre. This signal was successfully propagated down the motor neurons to a selected group of motor units in the muscle. Conclusion An anatomically and physiologically based model of the posterior motor neurons in the human lower limb was developed. This

  13. 3D reconstruction of carotid atherosclerotic plaque: comparison between spatial compound ultrasound models and anatomical models

    DEFF Research Database (Denmark)

    Lind, Bo L.; Fagertun, Jens; Wilhjelm, Jens E.;

    2007-01-01

    This study deals with the creation of 3D models that can work as a tool for discriminating between tissue and background in the development of tissue classification methods. Ten formalin-fixed atherosclerotic carotid plaques removed by endarterectomy were scanned with 3D multi-angle spatial...... compound ultrasound (US) and subsequently sliced and photographed to produce a 3D anatomical data set. Outlines in the ultrasound data were found by means of active contours and combined into 10 3D ultrasound models. The plaque regions of the anatomical photographs were outlined manually and then combined...... into 10 3D anatomical models. The volumes of the anatomical models correlated with the volume found by a water displacement method (r = 0.95), except for an offset. The models were compared in three ways. Visual inspection showed quite good agreement between the models. The volumes of the ultrasound...

  14. Generic Model to Send Secure Alerts for Utility Companies

    Directory of Open Access Journals (Sweden)

    Perez–Díaz J.A.

    2010-04-01

    Full Text Available In some industries such as logistics services, bank services, and others, the use of automated systems that deliver critical business information anytime and anywhere play an important role in the decision making process. This paper introduces a "Generic model to send secure alerts and notifications", which operates as a middleware between enterprise data sources and its mobile users. This model uses Short Message Service (SMS as its main mobile messaging technology, however is open to use new types of messaging technologies. Our model is interoperable with existing information systems, it can store any kind of information about alerts or notifications at different levels of granularity, it offers different types of notifications (as analert when critical business problems occur,asanotificationina periodical basis or as 2 way query. Notification rules can be customized by final users according to their preferences. The model provides a security framework in the cases where information requires confidentiality, it is extensible to existing and new messaging technologies (like e–mail, MMS, etc. It is a platform, mobile operator and hardware independent. Currently, our solution is being used at the Comisión Federal de Electricidad (Mexico's utility company to deliver secure alerts related to critical events registered in the main power generation plants of our country.

  15. Mathematical modelling of the growth of human fetus anatomical structures.

    Science.gov (United States)

    Dudek, Krzysztof; Kędzia, Wojciech; Kędzia, Emilia; Kędzia, Alicja; Derkowski, Wojciech

    2016-07-08

    The goal of this study was to present a procedure that would enable mathematical analysis of the increase of linear sizes of human anatomical structures, estimate mathematical model parameters and evaluate their adequacy. Section material consisted of 67 foetuses-rectus abdominis muscle and 75 foetuses- biceps femoris muscle. The following methods were incorporated to the study: preparation and anthropologic methods, image digital acquisition, Image J computer system measurements and statistical analysis method. We used an anthropologic method based on age determination with the use of crown-rump length-CRL (V-TUB) by Scammon and Calkins. The choice of mathematical function should be based on a real course of the curve presenting growth of anatomical structure linear size Ύ in subsequent weeks t of pregnancy. Size changes can be described with a segmental-linear model or one-function model with accuracy adequate enough for clinical purposes. The interdependence of size-age is described with many functions. However, the following functions are most often considered: linear, polynomial, spline, logarithmic, power, exponential, power-exponential, log-logistic I and II, Gompertz's I and II and von Bertalanffy's function. With the use of the procedures described above, mathematical models parameters were assessed for V-PL (the total length of body) and CRL body length increases, rectus abdominis total length h, its segments hI, hII, hIII, hIV, as well as biceps femoris length and width of long head (LHL and LHW) and of short head (SHL and SHW). The best adjustments to measurement results were observed in the exponential and Gompertz's models.

  16. A generic hydroeconomic model to assess future water scarcity

    Science.gov (United States)

    Neverre, Noémie; Dumas, Patrice

    2015-04-01

    We developed a generic hydroeconomic model able to confront future water supply and demand on a large scale, taking into account man-made reservoirs. The assessment is done at the scale of river basins, using only globally available data; the methodology can thus be generalized. On the supply side, we evaluate the impacts of climate change on water resources. The available quantity of water at each site is computed using the following information: runoff is taken from the outputs of CNRM climate model (Dubois et al., 2010), reservoirs are located using Aquastat, and the sub-basin flow-accumulation area of each reservoir is determined based on a Digital Elevation Model (HYDRO1k). On the demand side, agricultural and domestic demands are projected in terms of both quantity and economic value. For the agricultural sector, globally available data on irrigated areas and crops are combined in order to determine irrigated crops localization. Then, crops irrigation requirements are computed for the different stages of the growing season using Allen (1998) method with Hargreaves potential evapotranspiration. Irrigation water economic value is based on a yield comparison approach between rainfed and irrigated crops. Potential irrigated and rainfed yields are taken from LPJmL (Blondeau et al., 2007), or from FAOSTAT by making simple assumptions on yield ratios. For the domestic sector, we project the combined effects of demographic growth, economic development and water cost evolution on future demands. The method consists in building three-blocks inverse demand functions where volume limits of the blocks evolve with the level of GDP per capita. The value of water along the demand curve is determined from price-elasticity, price and demand data from the literature, using the point-expansion method, and from water costs data. Then projected demands are confronted to future water availability. Operating rules of the reservoirs and water allocation between demands are based on

  17. Multivariate models of inter-subject anatomical variability.

    Science.gov (United States)

    Ashburner, John; Klöppel, Stefan

    2011-05-15

    This paper presents a very selective review of some of the approaches for multivariate modelling of inter-subject variability among brain images. It focusses on applying probabilistic kernel-based pattern recognition approaches to pre-processed anatomical MRI, with the aim of most accurately modelling the difference between populations of subjects. Some of the principles underlying the pattern recognition approaches of Gaussian process classification and regression are briefly described, although the reader is advised to look elsewhere for full implementational details. Kernel pattern recognition methods require matrices that encode the degree of similarity between the images of each pair of subjects. This review focusses on similarity measures derived from the relative shapes of the subjects' brains. Pre-processing is viewed as generative modelling of anatomical variability, and there is a special emphasis on the diffeomorphic image registration framework, which provides a very parsimonious representation of relative shapes. Although the review is largely methodological, excessive mathematical notation is avoided as far as possible, as the paper attempts to convey a more intuitive understanding of various concepts. The paper should be of interest to readers wishing to apply pattern recognition methods to MRI data, with the aim of clinical diagnosis or biomarker development. It also tries to explain that the best models are those that most accurately predict, so similar approaches should also be relevant to basic science. Knowledge of some basic linear algebra and probability theory should make the review easier to follow, although it may still have something to offer to those readers whose mathematics may be more limited. Copyright © 2010 Elsevier Inc. All rights reserved.

  18. A Generic Danish Distribution Grid Model for Smart Grid Technology Testing

    DEFF Research Database (Denmark)

    Cha, Seung-Tae; Wu, Qiuwei; Østergaard, Jacob

    2012-01-01

    This paper describes the development of a generic Danish distribution grid model for smart grid technology testing based on the Bornholm power system. The frequency dependent network equivalent (FDNE) method has been used in order to accurately preserve the desired properties and characteristics...... as a generic Smart Grid benchmark model for testing purposes....

  19. Integration of Generic Multi-dimensional Model and Operational Policies for Batch Cooling Crystallization

    DEFF Research Database (Denmark)

    Abdul Samad, Noor Asma Fazli; Singh, Ravendra; Sin, Gürkan

    2011-01-01

    A generic multi-dimensional modeling framework for studying batch cooling crystallization processes under generated operational policies is presented. The generic nature of the modeling allows the study of a wide range of chemical systems under different operational scenarios, enabling thereby, t...

  20. Modeling Causal Learning Using Bayesian Generic Priors on Generative and Preventive Powers

    OpenAIRE

    Lu, Hongjing; Yuille, Alan L; Liljeholm, Mimi; Cheng, Patricia W.; Holyoak, Keith J.

    2006-01-01

    We present a Bayesian model of causal learning that incorporates generic priors on distributions of weights representing potential powers to either produce or prevent an effect. These generic priors favor necessary and sufficient causes. Across three experiments, the model explains the systematic pattern of human judgments observed for questions regarding support for a causal link, for both generative and preventive causes.

  1. Quantification of Scenario Distance within Generic WINNER Channel Model

    Directory of Open Access Journals (Sweden)

    Milan Narandžić

    2013-01-01

    Full Text Available Starting from the premise that stochastic properties of a radio environment can be abstracted by defining scenarios, a generic MIMO channel model is built by the WINNER project. The parameter space of the WINNER model is, among others, described by normal probability distributions and correlation coefficients that provide a suitable space for scenario comparison. The possibility to quantify the distance between reference scenarios and measurements enables objective comparison and classification of measurements into scenario classes. In this paper we approximate the WINNER scenarios with multivariate normal distributions and then use the mean Kullback-Leibler divergence to quantify their divergence. The results show that the WINNER scenario groups (A, B, C, and D or propagation classes (LoS, OLoS, and NLoS do not necessarily ensure minimum separation within the groups/classes. Instead, the following grouping minimizes intragroup distances: (i indoor-to-outdoor and outdoor-to-indoor scenarios (A2, B4, and C4, (ii macrocell configurations for suburban, urban, and rural scenarios (C1, C2, and D1, and (iii indoor/hotspot/microcellular scenarios (A1, B3, and B1. The computation of the divergence between Ilmenau and Dresden measurements and WINNER scenarios confirms that the parameters of the C2 scenario are a proper reference for a large variety of urban macrocell environments.

  2. Analysis of surgical intervention populations using generic surgical process models.

    Science.gov (United States)

    Neumuth, Thomas; Jannin, Pierre; Schlomberg, Juliane; Meixensberger, Jürgen; Wiedemann, Peter; Burgert, Oliver

    2011-01-01

    According to differences in patient characteristics, surgical performance, or used surgical technological resources, surgical interventions have high variability. No methods for the generation and comparison of statistical 'mean' surgical procedures are available. The convenience of these models is to provide increased evidence for clinical, technical, and administrative decision-making. Based on several measurements of patient individual surgical treatments, we present a method of how to calculate a statistical 'mean' intervention model, called generic Surgical Process Model (gSPM), from a number of interventions. In a proof-of-concept study, we show how statistical 'mean' procedure courses can be computed and how differences between several of these models can be quantified. Patient individual surgical treatments of 102 cataract interventions from eye surgery were allocated to an ambulatory or inpatient sample, and the gSPMs for each of the samples were computed. Both treatment strategies are exemplary compared for the interventional phase Capsulorhexis. Statistical differences between the gSPMs of ambulatory and inpatient procedures of performance times for surgical activities and activity sequences were identified. Furthermore, the work flow that corresponds to the general recommended clinical treatment was recovered out of the individual Surgical Process Models. The computation of gSPMs is a new approach in medical engineering and medical informatics. It supports increased evidence, e.g. for the application of alternative surgical strategies, investments for surgical technology, optimization protocols, or surgical education. Furthermore, this may be applicable in more technical research fields, as well, such as the development of surgical workflow management systems for the operating room of the future.

  3. Suction-generated noise in an anatomic silicon ear model.

    Science.gov (United States)

    Luxenberger, Wolfgang; Lahousen, T; Walch, C

    2012-10-01

    The objectives of this study were to evaluate noise levels generated during micro-suction aural toilet using an anatomic silicon ear model. It is an experimental study. In an anatomic ear model made of silicone, the eardrum was replaced by a 1-cm diameter microphone of a calibrated sound-level measuring device. Ear wax was removed using the sucker of a standard ENT treatment unit (Atmos Servant 5(®)). Mean and peak sound levels during the suction procedure were recorded with suckers of various diameters (Fergusson-Frazier 2.7-4 mm as well as Rosen 1.4-2.5 mm). Average noise levels during normal suction in a distance of 1 cm in front of the eardrum ranged between 97 and 103.5 dB(A) (broadband noise). Peak noise levels reached 118 dB(A). During partial obstruction of the sucker by cerumen or dermal flakes, peak noise levels reached 146 dB(A). Peak noise levels observed during the so-called clarinet phenomena were independent of the diameter or type of suckers used. Although micro-suction aural toilet is regarded as an established, widespread and usually safe method to clean the external auditory canal, some caution seems advisable. The performance of long-lasting suction periods straight in front of the eardrum without sound-protecting earwax between sucker and eardrum should be avoided. In particular, when clarinet phenomena are occurring (as described above), the suction procedure should be aborted immediately. In the presence of dermal flakes blocking the auditory canal, cleaning with micro-forceps or other non-suctioning instruments might represent a reasonable alternative.

  4. Lepton-flavour violating $B$ decays in generic $Z'$ models

    CERN Document Server

    Crivellin, Andreas; Matias, Joaquim; Nierste, Ulrich; Pokorski, Stefan; Rosiek, Janusz

    2015-01-01

    LHCb has reported deviations from the SM expectations in $B\\to K^* \\mu^+\\mu^-$ angular observables, in $B_s\\to\\phi\\mu^+\\mu^-$ and in ratio $R(K)=Br[B\\to K \\mu^+\\mu^-]/Br[B\\to K e^+e^-]$. For all three decays, a heavy neutral gauge boson mediating $b\\to s\\mu^+\\mu^-$ transitions is a prime candidate for an explanation. As $R(K)$ measures violation of lepton-flavour universality, it is interesting to examine the possibility that also lepton flavour is violated. In this article, we investigate the perspectives to discover the lepton-flavour violating modes $B\\to K^{(*)}\\tau^\\pm\\mu^\\mp$, $B_s\\to \\tau^\\pm\\mu^\\mp$ and $B\\to K^{(*)} \\mu^\\pm e^\\mp$, $B_s\\to \\mu^\\pm e^\\mp$. For this purpose we consider a simplified model in which new-physics effects originate from an additional neutral gauge boson ($Z^\\prime$) with generic couplings to quarks and leptons. The constraints from $\\tau\\to3\\mu$, $\\tau\\to\\mu\

  5. Creating a Generic Extended Enterprise Management Model using GERAM

    DEFF Research Database (Denmark)

    Larsen, Lars Bjørn; Kaas-Pedersen, Carsten; Vesterager, Johan

    1998-01-01

    The two main themes of the Globeman21 (Global Manufacturing in the 21st century) project are product life cycle management and extended enterprise management. This article focus on the later of these subjects and an illustration of the concept is given together with a discussion of the concept of...... management model. By working with GERAM in relation to extended enterprise management it has been found that it provides a useful background for organising knowledge, experience and the activities within the project......The two main themes of the Globeman21 (Global Manufacturing in the 21st century) project are product life cycle management and extended enterprise management. This article focus on the later of these subjects and an illustration of the concept is given together with a discussion of the concept...... of virtual enterprises. Through the introduction of GERAM (Generalised Enterprise Reference Architecture and Methodology) an initial version of a basic framework for extended enterprise management is introduced. This basic framework is the first step towards the creation of a generic extended enterprise...

  6. Towards a Generic Information Data Model for Verification, Validation & Accreditation VV&A

    NARCIS (Netherlands)

    Roza, Z.C.; Voogd, J.M.; Giannoulis, C.

    2008-01-01

    The Generic Methodology for Verification, Validation and Acceptance (GM-VV) is intended to provide a common generic framework for making formal and well balanced acceptance decisions on a specific usage of models, simulations and data. GM-VV will offer the international M&S community with a Verifica

  7. Computer-aided modeling framework – a generic modeling template for catalytic membrane fixed bed reactors

    DEFF Research Database (Denmark)

    Fedorova, Marina; Sin, Gürkan; Gani, Rafiqul

    2013-01-01

    This work focuses on development of computer-aided modeling framework. The framework is a knowledge-based system that is built on a generic modeling language and structured based on workflows for different general modeling tasks. The overall objective of this work is to support the model developers...... and users to generate and test models systematically, efficiently and reliably. In this way, development of products and processes can be faster, cheaper and very efficient. In this contribution, as part of the framework a generic modeling template for the systematic derivation of problem specific catalytic...... membrane fixed bed models is developed. The application of the modeling template is highlighted with a case study related to the modeling of a catalytic membrane reactor coupling dehydrogenation of ethylbenzene with hydrogenation of nitrobenzene....

  8. Generic Engineering Competencies: A Review and Modelling Approach

    Science.gov (United States)

    Male, Sally A.

    2010-01-01

    This paper puts forward the view that engineering educators have a responsibility to prepare graduates for engineering work and careers. The current literature reveals gaps between the competencies required for engineering work and those developed in engineering education. Generic competencies feature in these competency gaps. Literature suggests…

  9. Modeling of Protection in Dynamic Simulation Using Generic Relay Models and Settings

    Energy Technology Data Exchange (ETDEWEB)

    Samaan, Nader A.; Dagle, Jeffery E.; Makarov, Yuri V.; Diao, Ruisheng; Vallem, Mallikarjuna R.; Nguyen, Tony B.; Miller, Laurie E.; Vyakaranam, Bharat; Tuffner, Francis K.; Pai, M. A.; Conto, Jose; Kang, Sun Wook

    2016-07-19

    This paper shows how generic protection relay models available in planning tools can be augmented with settings that are based on NERC standards or best engineering practice. Selected generic relay models in Siemens PSS®E have been used in dynamic simulations in the proposed approach. Undervoltage, overvoltage, underfrequency, and overfrequency relays have been modeled for each generating unit. Distance-relay protection was modeled for transmission system protection. Two types of load-shedding schemes were modeled: underfrequency (frequency-responsive non-firm load shedding) and underfrequency and undervoltage firm load shedding. Several case studies are given to show the impact of protection devices on dynamic simulations. This is useful for simulating cascading outages.

  10. Cooperative Monitoring Center Occasional Paper/7: A Generic Model for Cooperative Border Security

    Energy Technology Data Exchange (ETDEWEB)

    Netzer, Colonel Gideon

    1999-03-01

    This paper presents a generic model for dealing with security problems along borders between countries. It presents descriptions and characteristics of various borders and identifies the threats to border security, while emphasizing cooperative monitoring solutions.

  11. Functionalized anatomical models for EM-neuron Interaction modeling

    Science.gov (United States)

    Neufeld, Esra; Cassará, Antonino Mario; Montanaro, Hazael; Kuster, Niels; Kainz, Wolfgang

    2016-06-01

    The understanding of interactions between electromagnetic (EM) fields and nerves are crucial in contexts ranging from therapeutic neurostimulation to low frequency EM exposure safety. To properly consider the impact of in vivo induced field inhomogeneity on non-linear neuronal dynamics, coupled EM-neuronal dynamics modeling is required. For that purpose, novel functionalized computable human phantoms have been developed. Their implementation and the systematic verification of the integrated anisotropic quasi-static EM solver and neuronal dynamics modeling functionality, based on the method of manufactured solutions and numerical reference data, is described. Electric and magnetic stimulation of the ulnar and sciatic nerve were modeled to help understanding a range of controversial issues related to the magnitude and optimal determination of strength-duration (SD) time constants. The results indicate the importance of considering the stimulation-specific inhomogeneous field distributions (especially at tissue interfaces), realistic models of non-linear neuronal dynamics, very short pulses, and suitable SD extrapolation models. These results and the functionalized computable phantom will influence and support the development of safe and effective neuroprosthetic devices and novel electroceuticals. Furthermore they will assist the evaluation of existing low frequency exposure standards for the entire population under all exposure conditions.

  12. Modeling multi-clocked data-flow programs using the Generic Modeling Environment

    OpenAIRE

    Brunette, Christian; Talpin, Jean-Pierre; Besnard, Loïc; Gautier, Thierry

    2006-01-01

    International audience; This paper presents Signal-Meta, the metamodel designed for the synchronous data-flow language Signal. It relies on the Generic Modeling Environment (GME), a configurable object-oriented toolkit that supports the creation of domain-specific modeling and program synthesis environments. The graphical description constitutes the base to build multi-clock environments, and a good front-end for the Polychrony platform. To complete this frontend, we develop a tool that trans...

  13. Implementation and Validation of IEC Generic Type 1A Wind Turbine Generator Model

    DEFF Research Database (Denmark)

    Zhao, Haoran; Wu, Qiuwei; Margaris, Ioannis

    2015-01-01

    This paper presents the implementation of the International Electrotechnical Commission (IEC) generic Type 1A wind turbine generator (WTG) model in Power Factory (PF) and the validation of the implemented model against field measurements. The IEC generic Type 1A WTG model structure is briefly...... described. The details are explained regarding how the two mass mechanical model is implemented when the generator mass is included in the PF built-in generator model. In order to verify the IEC generic Type 1A WTG model, the model to field measurement validation method was employed. The model to field...... the simulation results and measurements were calculated according to the voltage dip windows and the index definition specified in the IEC 61400-27-1 committee draft. Copyright © 2014 John Wiley & Sons, Ltd....

  14. Performance Evaluation of Color Models in the Fusion of Functional and Anatomical Images.

    Science.gov (United States)

    Ganasala, Padma; Kumar, Vinod; Prasad, A D

    2016-05-01

    Fusion of the functional image with an anatomical image provides additional diagnostic information. It is widely used in diagnosis, treatment planning, and follow-up of oncology. Functional image is a low-resolution pseudo color image representing the uptake of radioactive tracer that gives the important metabolic information. Whereas, anatomical image is a high-resolution gray scale image that gives structural details. Fused image should consist of all the anatomical details without any changes in the functional content. This is achieved through fusion in de-correlated color model and the choice of color model has greater impact on the fusion outcome. In the present work, suitability of different color models for functional and anatomical image fusion is studied. After converting the functional image into de-correlated color model, the achromatic component of functional image is fused with an anatomical image by using proposed nonsubsampled shearlet transform (NSST) based image fusion algorithm to get new achromatic component with all the anatomical details. This new achromatic and original chromatic channels of functional image are converted to RGB format to get fused functional and anatomical image. Fusion is performed in different color models. Different cases of SPECT-MRI images are used for this color model study. Based on visual and quantitative analysis of fused images, the best color model for the stated purpose is determined.

  15. Performance Assessment Modeling and Sensitivity Analyses of Generic Disposal System Concepts.

    Energy Technology Data Exchange (ETDEWEB)

    Sevougian, S. David; Freeze, Geoffrey A.; Gardner, William Payton; Hammond, Glenn Edward; Mariner, Paul

    2014-09-01

    directly, rather than through simplified abstractions. It also a llows for complex representations of the source term, e.g., the explicit representation of many individual waste packages (i.e., meter - scale detail of an entire waste emplacement drift). This report fulfills the Generic Disposal System Analysis Work Packa ge Level 3 Milestone - Performance Assessment Modeling and Sensitivity Analyses of Generic Disposal System Concepts (M 3 FT - 1 4 SN08080 3 2 ).

  16. Combining engineering and data-driven approaches: Development of a generic fire risk model facilitating calibration

    DEFF Research Database (Denmark)

    De Sanctis, G.; Fischer, K.; Kohler, J.

    2014-01-01

    Fire risk models support decision making for engineering problems under the consistent consideration of the associated uncertainties. Empirical approaches can be used for cost-benefit studies when enough data about the decision problem are available. But often the empirical approaches...... a generic risk model that is calibrated to observed fire loss data. Generic risk models assess the risk of buildings based on specific risk indicators and support risk assessment at a portfolio level. After an introduction to the principles of generic risk assessment, the focus of the present paper...... are not detailed enough. Engineering risk models, on the other hand, may be detailed but typically involve assumptions that may result in a biased risk assessment and make a cost-benefit study problematic. In two related papers it is shown how engineering and data-driven modeling can be combined by developing...

  17. Optimisation of a Generic Ionic Model of Cardiac Myocyte Electrical Activity

    Directory of Open Access Journals (Sweden)

    Tianruo Guo

    2013-01-01

    Full Text Available A generic cardiomyocyte ionic model, whose complexity lies between a simple phenomenological formulation and a biophysically detailed ionic membrane current description, is presented. The model provides a user-defined number of ionic currents, employing two-gate Hodgkin-Huxley type kinetics. Its generic nature allows accurate reconstruction of action potential waveforms recorded experimentally from a range of cardiac myocytes. Using a multiobjective optimisation approach, the generic ionic model was optimised to accurately reproduce multiple action potential waveforms recorded from central and peripheral sinoatrial nodes and right atrial and left atrial myocytes from rabbit cardiac tissue preparations, under different electrical stimulus protocols and pharmacological conditions. When fitted simultaneously to multiple datasets, the time course of several physiologically realistic ionic currents could be reconstructed. Model behaviours tend to be well identified when extra experimental information is incorporated into the optimisation.

  18. Generic camera model and its calibration for computational integral imaging and 3D reconstruction.

    Science.gov (United States)

    Li, Weiming; Li, Youfu

    2011-03-01

    Integral imaging (II) is an important 3D imaging technology. To reconstruct 3D information of the viewed objects, modeling and calibrating the optical pickup process of II are necessary. This work focuses on the modeling and calibration of an II system consisting of a lenslet array, an imaging lens, and a charge-coupled device camera. Most existing work on such systems assumes a pinhole array model (PAM). In this work, we explore a generic camera model that accommodates more generality. This model is an empirical model based on measurements, and we constructed a setup for its calibration. Experimental results show a significant difference between the generic camera model and the PAM. Images of planar patterns and 3D objects were computationally reconstructed with the generic camera model. Compared with the images reconstructed using the PAM, the images present higher fidelity and preserve more high spatial frequency components. To the best of our knowledge, this is the first attempt in applying a generic camera model to an II system.

  19. Anatomical models and wax Venuses: art masterpieces or scientific craft works?

    Science.gov (United States)

    Ballestriero, R

    2010-02-01

    The art of wax modelling has an ancient origin but rose to prominence in 14th century Italy with the cult of votive artefacts. With the advent of Neoclassicism this art, now deemed repulsive, continued to survive in a scientific environment, where it flourished in the study of normal and pathological anatomy, obstetrics, zoology and botany. The achievement of having originated the creation of anatomical models in coloured wax must be ascribed to a joint effort undertaken by the Sicilian wax modeller Gaetano Giulio Zumbo and the French surgeon Guillaume Desnoues in the late 17th century. Interest in anatomical wax models spread throughout Europe during the 18th century, first in Bologna with Ercole Lelli, Giovanni Manzolini and Anna Morandi, and then in Florence with Felice Fontana and Clemente Susini. In England, the art of anatomical ceroplastics was brought to London from Florence by the sculptor Joseph Towne. Throughout the centuries many anatomical artists preferred this material due to the remarkable mimetic likeness obtained, far surpassing any other material. Independent of the material used, whether wood, wax or clay, anatomical models were always considered merely craft works confined to hospitals or faculties of medicine and have survived to this day only because of their scientific interest. Italian and English waxes are stylistically different but the remarkable results obtained by Susini and Towne, and the fact that some contemporary artists are again representing anatomical wax bodies in their works, makes the border that formerly separated art and craft indistinguishable.

  20. A Generic Length-scale Equation For Second-order Turbulence Models of Oceanic Boundary Layers

    Science.gov (United States)

    Umlauf, L.; Burchard, H.

    A generic transport equation for a generalized length-scale in second-order turbulence closure models for geophysical boundary layers is suggested. This variable consists of the products of powers of the turbulent kinetic energy, k, and the integral length-scale, l. The new approach generalizes traditional second-order models used in geophysical boundary layer modelling, e.g. the Mellor-Yamada model and the k- model, which, however, can be recovered as special cases. It is demonstrated how this new model can be calibrated with measurements in some typical geophysical boundary layer flows. As an example, the generic model is applied to the uppermost oceanic boundary layer directly influenced by the effects of breaking surface waves. Recent measurements show that in this layer the classical law of the wall is invalid, since there turbulence is dominated by turbulent transport of TKE from above, and not by shear-production. A widely accepted approach to describe the wave-affected layer with a one-equation turbulence model was suggested by Craig and Banner (1994). Here, some deficien- cies of their solutions are pointed out and a generalization of their ideas for the case of two-equation models is suggested. Direct comparison with very recently obtained measurements of the dissipation rate, , in the wave-affected boundary layer with com- puted results clearly demonstrate that only the generic two-equation model yields cor- rect predictions for the profiles of and the turbulent length scale, l. Also, the pre- dicted velocity profiles in the wave-affected layer, important e.g. for the interpretation of surface drifter experiments, are reproduced correctly only by the generic model. Implementation and computational costs of the generic model are comparable with traditonal two-equation models.

  1. Toward a generic model of security in organizational context: exploring insider threats to information infrastructure.

    Energy Technology Data Exchange (ETDEWEB)

    Martinez-Moyano, I. J.; Samsa, M. E.; Burke, J. F.; Akcam, B. K.; Decision and Information Sciences; Rockefeller Coll. at the State Univ. of New York at Albany

    2008-01-01

    This paper presents a generic model for information security implementation in organizations. The model presented here is part of an ongoing research stream related to critical infrastructure protection and insider threat and attack analysis. This paper discusses the information security implementation case.

  2. Theoretical Evaluation of the Sediment/Water Exchange Description in Generic Compartment Models (SimpleBox)

    DEFF Research Database (Denmark)

    Sørensen, P. B.; Fauser, P.; Carlsen, L.

    It is shown how diffusion and deposition of solids drive the flux of substance between the water column and the sediment. The generic compartment models (Mackay type) use a one box model for the sediment in order to keep the calculations simple. However, when diffusion needs to be included...

  3. Support of the Generic Framework programme : calibration of groundwater flow models

    NARCIS (Netherlands)

    Stroet, Chris C.B.M. te; Minnema, Benny

    2003-01-01

    This report is to support the “Generic Framework programme” which consists of a series of projects to create a standard in the modelling processes that are used in water management issues. The topic of support is the field of model calibration. TNO-NITG is elaborating the calibration of groundwater

  4. Analysis of a generic model for a bottleneck link in an integrated services communications network

    NARCIS (Netherlands)

    Al-Begain, K.; Heindl, A.; Telek, M.; Litjens, R.; Boucherie, R.J.

    2007-01-01

    We develop and analyse a generic model for performance evaluation, parameter optimisation and dimensioning of a bottleneck link in an integrated services communications network. Possible application areas include ip, atm and gsm/gprs networks. The model enables analytical evaluation for a scenario o

  5. A generic model for keeping quality of vegetable produce during storage and distribution

    NARCIS (Netherlands)

    Tijskens, L.M.M.; Polderdijk, J.J.

    1996-01-01

    A generic model on the keeping quality of perishable produce was formulated, based on the kinetics of the decrease of individual quality attributes. The model includes the effects of temperature, chilling injury and different levels of initial quality and of quality acceptance limits. Keeping qualit

  6. A deformable generic 3D model of haptoral anchor of Monogenean.

    Directory of Open Access Journals (Sweden)

    Bee Guan Teo

    Full Text Available In this paper, a digital 3D model which allows for visualisation in three dimensions and interactive manipulation is explored as a tool to help us understand the structural morphology and elucidate the functions of morphological structures of fragile microorganisms which defy live studies. We developed a deformable generic 3D model of haptoral anchor of dactylogyridean monogeneans that can subsequently be deformed into different desired anchor shapes by using direct manipulation deformation technique. We used point primitives to construct the rectangular building blocks to develop our deformable 3D model. Point primitives are manually marked on a 2D illustration of an anchor on a Cartesian graph paper and a set of Cartesian coordinates for each point primitive is manually extracted from the graph paper. A Python script is then written in Blender to construct 3D rectangular building blocks based on the Cartesian coordinates. The rectangular building blocks are stacked on top or by the side of each other following their respective Cartesian coordinates of point primitive. More point primitives are added at the sites in the 3D model where more structural variations are likely to occur, in order to generate complex anchor structures. We used Catmull-Clark subdivision surface modifier to smoothen the surface and edge of the generic 3D model to obtain a smoother and more natural 3D shape and antialiasing option to reduce the jagged edges of the 3D model. This deformable generic 3D model can be deformed into different desired 3D anchor shapes through direct manipulation deformation technique by aligning the vertices (pilot points of the newly developed deformable generic 3D model onto the 2D illustrations of the desired shapes and moving the vertices until the desire 3D shapes are formed. In this generic 3D model all the vertices present are deployed for displacement during deformation.

  7. A generic detailed rigid-body lumbar spine model

    DEFF Research Database (Denmark)

    De Zee, Mark; Hansen, Lone; Wong, Christian

    2007-01-01

    effort of different research groups. The model is defined in a text-based, declarative, object-oriented language in the AnyBody Modelling System software. Text-based models will facilitate sharing of the models between different research groups. The necessary data for the model has been taken from...... is relatively easy to share and modify due to the use of a well-defined and self-contained scripting language. Validation is though still necessary for specific cases....

  8. Can generic knee joint models improve the measurement of osteoarthritic knee kinematics during squatting activity?

    Science.gov (United States)

    Clément, Julien; Dumas, Raphaël; Hagemeister, Nicola; de Guise, Jaques A

    2017-01-01

    Knee joint kinematics derived from multi-body optimisation (MBO) still requires evaluation. The objective of this study was to corroborate model-derived kinematics of osteoarthritic knees obtained using four generic knee joint models used in musculoskeletal modelling - spherical, hinge, degree-of-freedom coupling curves and parallel mechanism - against reference knee kinematics measured by stereo-radiography. Root mean square errors ranged from 0.7° to 23.4° for knee rotations and from 0.6 to 9.0 mm for knee displacements. Model-derived knee kinematics computed from generic knee joint models was inaccurate. Future developments and experiments should improve the reliability of osteoarthritic knee models in MBO and musculoskeletal modelling.

  9. Compositional Model-Views with Generic Graphical User Interfaces

    NARCIS (Netherlands)

    Achten, P.M.; Eekelen, M.C.J.D. van; Plasmeijer, M.J.

    2004-01-01

    Creating GUI programs is hard even for prototyping purposes. Using the model-view paradigm makes it somewhat simpler since the model-view paradigm dictates that the model contains no GUI programming, as this is done by the views. Still, a lot of GUI programming is needed to implement the views. We

  10. A Generic Software Framework for Data Assimilation and Model Calibration

    NARCIS (Netherlands)

    Van Velzen, N.

    2010-01-01

    The accuracy of dynamic simulation models can be increased by using observations in conjunction with a data assimilation or model calibration algorithm. However, implementing such algorithms usually increases the complexity of the model software significantly. By using concepts from object oriented

  11. Exact solution of the XXX Gaudin model with generic open boundaries

    Science.gov (United States)

    Hao, Kun; Cao, Junpeng; Yang, Tao; Yang, Wen-Li

    2015-03-01

    The XXX Gaudin model with generic integrable open boundaries specified by the most general non-diagonal reflecting matrices is studied. Besides the inhomogeneous parameters, the associated Gaudin operators have six free parameters which break the U(1) -symmetry. With the help of the off-diagonal Bethe ansatz, we successfully obtained the eigenvalues of these Gaudin operators and the corresponding Bethe ansatz equations.

  12. Exact solution of the XXX Gaudin model with the generic open boundaries

    CERN Document Server

    Hao, Kun; Yang, Tao; Yang, Wen-Li

    2014-01-01

    The XXX Gaudin model with generic integrable boundaries specified by the most general non-diagonal K-matrices is studied by the off-diagonal Bethe ansatz method. The eigenvalues of the associated Gaudin operators and the corresponding Bethe ansatz equations are obtained.

  13. A generic simulation cell method for developing extensible, efficient and readable parallel computational models

    Science.gov (United States)

    Honkonen, I.

    2015-03-01

    I present a method for developing extensible and modular computational models without sacrificing serial or parallel performance or source code readability. By using a generic simulation cell method I show that it is possible to combine several distinct computational models to run in the same computational grid without requiring modification of existing code. This is an advantage for the development and testing of, e.g., geoscientific software as each submodel can be developed and tested independently and subsequently used without modification in a more complex coupled program. An implementation of the generic simulation cell method presented here, generic simulation cell class (gensimcell), also includes support for parallel programming by allowing model developers to select which simulation variables of, e.g., a domain-decomposed model to transfer between processes via a Message Passing Interface (MPI) library. This allows the communication strategy of a program to be formalized by explicitly stating which variables must be transferred between processes for the correct functionality of each submodel and the entire program. The generic simulation cell class requires a C++ compiler that supports a version of the language standardized in 2011 (C++11). The code is available at https://github.com/nasailja/gensimcell for everyone to use, study, modify and redistribute; those who do are kindly requested to acknowledge and cite this work.

  14. Developing a generic model for total quality management in higher education in Saudi Arabia.

    Science.gov (United States)

    Al-Shafei, Ahmad I; Bin Abdulrahman, Khalid; Al-Qumaizi, Khalid I; El-Mardi, Abdelmoniem S

    2015-04-01

    The field of higher education has been progressing at a rapid pace in the Kingdom of Saudi Arabia over the past decade, with doubling the number of government and private universities and colleges. Quality and accreditation are of great importance to higher education institutes world-wide. Thus, developing a generic model for quality management in higher education is badly needed in the country.

  15. Generic Form of Bayesian Monte Carlo For Models With Partial Monotonicity

    NARCIS (Netherlands)

    Rajabalinejad, M.

    2012-01-01

    This paper presents a generic method for the safety assessments of models with partial monotonicity. For this purpose, a Bayesian interpolation method is developed and implemented in the Monte Carlo process. integrated approach is the generalization of the recently developed techniques used in safet

  16. Generic form of Bayesian Monte Carlo for models with partial monotonicity

    NARCIS (Netherlands)

    Rajabalinejad, M.; Spitas, C.

    2012-01-01

    This paper presents a generic method for the safety assessments of models with partial monotonicity. For this purpose, a Bayesian interpolation method is developed and implemented in the Monte Carlo process. integrated approach is the generalization of the recently developed techniques used in safet

  17. Clay Generic Disposal System Model - Sensitivity Analysis for 32 PWR Assembly Canisters (+2 associated model files).

    Energy Technology Data Exchange (ETDEWEB)

    Morris, Edgar [Argonne National Lab. (ANL), Argonne, IL (United States)

    2014-10-01

    The Used Fuel Disposition Campaign (UFDC), as part of the DOE Office of Nuclear Energy’s (DOE-NE) Fuel Cycle Technology program (FCT) is investigating the disposal of high level radioactive waste (HLW) and spent nuclear fuela (SNF) in a variety of geologic media. The feasibility of disposing SNF and HLW in clay media has been investigated and has been shown to be promising [Ref. 1]. In addition the disposal of these wastes in clay media is being investigated in Belgium, France, and Switzerland. Thus, Argillaceous media is one of the environments being considered by UFDC. As identified by researchers at Sandia National Laboratory, potentially suitable formations that may exist in the U.S. include mudstone, clay, shale, and argillite formations [Ref. 1]. These formations encompass a broad range of material properties. In this report, reference to clay media is intended to cover the full range of material properties. This report presents the status of the development of a simulation model for evaluating the performance of generic clay media. The clay Generic Disposal System Model (GDSM) repository performance simulation tool has been developed with the flexibility to evaluate not only different properties, but different waste streams/forms and different repository designs and engineered barrier configurations/ materials that could be used to dispose of these wastes.

  18. A generic model for lipid monolayers, bilayers, and membranes

    CERN Document Server

    Schmid, F; Lenz, O; West, B

    2007-01-01

    We describe a simple coarse-grained model which is suited to study lipid layers and their phase transitions. Lipids are modeled by short semiflexible chains of beads with a solvophilic head and a solvophobic tail component. They are forced to self-assemble into bilayers by a computationally cheap `phantom solvent' environment. The model reproduces the most important phases and phase transitions of monolayers and bilayers. Technical issues such as Monte Carlo parallelization schemes are briefly discussed.

  19. Investigation of an alternative generic model for predicting pharmacokinetic changes during physiological stress.

    Science.gov (United States)

    Peng, Henry T; Edginton, Andrea N; Cheung, Bob

    2013-10-01

    Physiologically based pharmacokinetic models were developed using MATLAB Simulink® and PK-Sim®. We compared the capability and usefulness of these two models by simulating pharmacokinetic changes of midazolam under exercise and heat stress to verify the usefulness of MATLAB Simulink® as a generic PBPK modeling software. Although both models show good agreement with experimental data obtained under resting condition, their predictions of pharmacokinetics changes are less accurate in the stressful conditions. However, MATLAB Simulink® may be more flexible to include physiologically based processes such as oral absorption and simulate various stress parameters such as stress intensity, duration and timing of drug administration to improve model performance. Further work will be conducted to modify algorithms in our generic model developed using MATLAB Simulink® and to investigate pharmacokinetics under other physiological stress such as trauma. © The Author(s) 2013.

  20. Generic Raman-based calibration models enabling real-time monitoring of cell culture bioreactors.

    Science.gov (United States)

    Mehdizadeh, Hamidreza; Lauri, David; Karry, Krizia M; Moshgbar, Mojgan; Procopio-Melino, Renee; Drapeau, Denis

    2015-01-01

    Raman-based multivariate calibration models have been developed for real-time in situ monitoring of multiple process parameters within cell culture bioreactors. Developed models are generic, in the sense that they are applicable to various products, media, and cell lines based on Chinese Hamster Ovarian (CHO) host cells, and are scalable to large pilot and manufacturing scales. Several batches using different CHO-based cell lines and corresponding proprietary media and process conditions have been used to generate calibration datasets, and models have been validated using independent datasets from separate batch runs. All models have been validated to be generic and capable of predicting process parameters with acceptable accuracy. The developed models allow monitoring multiple key bioprocess metabolic variables, and hence can be utilized as an important enabling tool for Quality by Design approaches which are strongly supported by the U.S. Food and Drug Administration.

  1. A Visual Meta-Language for Generic Modeling

    Science.gov (United States)

    2007-11-02

    since models provide a communication mechanism. Modeling languages can be textual or visual. Kim Marriot and Bernd Meyer describe visual languages as...150, January 1997, USA. [MAR98A] Marriot , Kim, Bernd Meyer, Visual Language Theory, Articles of Workshop on Theory of Visual Languages (TVL ’96...1998, Spring-Verlag New York, USA. [MAR98B] Marriot , Kim, Bernd Meyer, Kent B. Wittenburg, “A Survey of Visual Language Specification and

  2. Sensitivity of predicted muscle forces during gait to anatomical variability in musculotendon geometry.

    Science.gov (United States)

    Bosmans, Lode; Valente, Giordano; Wesseling, Mariska; Van Campen, Anke; De Groote, Friedl; De Schutter, Joris; Jonkers, Ilse

    2015-07-16

    Scaled generic musculoskeletal models are commonly used to drive dynamic simulations of motions. It is however, acknowledged that not accounting for variability in musculoskeletal geometry and musculotendon parameters may confound the simulation results, even when analysing control subjects. This study documents the three-dimensional anatomical variability of musculotendon origins and insertions of 33 lower limb muscles determined based on magnetic resonance imaging in six subjects. This anatomical variability was compared to the musculotendon point location in a generic musculoskeletal model. Furthermore, the sensitivity of muscle forces during gait, calculated using static optimization, to perturbations of the musculotendon point location was analyzed with a generic model. More specific, a probabilistic approach was used: for each analyzed musculotendon point, the three-dimensional location was re-sampled with a uniform Latin hypercube method within the anatomical variability and the static optimization problem was then re-solved for all perturbations. We found that musculotendon point locations in the generic model showed only variable correspondences with the anatomical variability. The anatomical variability of musculotendon point location did affect the calculated muscle forces: muscles most sensitive to perturbations within the anatomical variability are iliacus and psoas. Perturbation of the gluteus medius anterior, iliacus and psoas induces the largest concomitant changes in muscle forces of the unperturbed muscles. Therefore, when creating subject-specific musculoskeletal models, these attachment points should be defined accurately. In addition, the size of the anatomical variability of the musculotendon point location was not related to the sensitivity of the calculated muscle forces.

  3. Demonstration of Therapeutic Equivalence of Fluconazole Generic Products in the Neutropenic Mouse Model of Disseminated Candidiasis.

    Science.gov (United States)

    Gonzalez, Javier M; Rodriguez, Carlos A; Zuluaga, Andres F; Agudelo, Maria; Vesga, Omar

    2015-01-01

    Some generics of antibacterials fail therapeutic equivalence despite being pharmaceutical equivalents of their innovators, but data are scarce with antifungals. We used the neutropenic mice model of disseminated candidiasis to challenge the therapeutic equivalence of three generic products of fluconazole compared with the innovator in terms of concentration of the active pharmaceutical ingredient, analytical chemistry (liquid chromatography/mass spectrometry), in vitro susceptibility testing, single-dose serum pharmacokinetics in infected mice, and in vivo pharmacodynamics. Neutropenic, five week-old, murine pathogen free male mice of the strain Udea:ICR(CD-2) were injected in the tail vein with Candida albicans GRP-0144 (MIC = 0.25 mg/L) or Candida albicans CIB-19177 (MIC = 4 mg/L). Subcutaneous therapy with fluconazole (generics or innovator) and sterile saline (untreated controls) started 2 h after infection and ended 24 h later, with doses ranging from no effect to maximal effect (1 to 128 mg/kg per day) divided every 3 or 6 hours. The Hill's model was fitted to the data by nonlinear regression, and results from each group compared by curve fitting analysis. All products were identical in terms of concentration, chromatographic and spectrographic profiles, MICs, mouse pharmacokinetics, and in vivo pharmacodynamic parameters. In conclusion, the generic products studied were pharmaceutically and therapeutically equivalent to the innovator of fluconazole.

  4. Demonstration of Therapeutic Equivalence of Fluconazole Generic Products in the Neutropenic Mouse Model of Disseminated Candidiasis.

    Directory of Open Access Journals (Sweden)

    Javier M Gonzalez

    Full Text Available Some generics of antibacterials fail therapeutic equivalence despite being pharmaceutical equivalents of their innovators, but data are scarce with antifungals. We used the neutropenic mice model of disseminated candidiasis to challenge the therapeutic equivalence of three generic products of fluconazole compared with the innovator in terms of concentration of the active pharmaceutical ingredient, analytical chemistry (liquid chromatography/mass spectrometry, in vitro susceptibility testing, single-dose serum pharmacokinetics in infected mice, and in vivo pharmacodynamics. Neutropenic, five week-old, murine pathogen free male mice of the strain Udea:ICR(CD-2 were injected in the tail vein with Candida albicans GRP-0144 (MIC = 0.25 mg/L or Candida albicans CIB-19177 (MIC = 4 mg/L. Subcutaneous therapy with fluconazole (generics or innovator and sterile saline (untreated controls started 2 h after infection and ended 24 h later, with doses ranging from no effect to maximal effect (1 to 128 mg/kg per day divided every 3 or 6 hours. The Hill's model was fitted to the data by nonlinear regression, and results from each group compared by curve fitting analysis. All products were identical in terms of concentration, chromatographic and spectrographic profiles, MICs, mouse pharmacokinetics, and in vivo pharmacodynamic parameters. In conclusion, the generic products studied were pharmaceutically and therapeutically equivalent to the innovator of fluconazole.

  5. Towards a generic rainfall-runoff model for green roofs.

    Science.gov (United States)

    Kasmin, H; Stovin, V R; Hathway, E A

    2010-01-01

    A simple conceptual model for green roof hydrological processes is shown to reproduce monitored data, both during a storm event, and over a longer continuous simulation period. The model comprises a substrate moisture storage component and a transient storage component. Storage within the substrate represents the roof's overall stormwater retention capacity (or initial losses). Following a storm event the retention capacity is restored by evapotranspiration (ET). However, standard methods for quantifying ET do not exist. Monthly ET values are identified using four different approaches: analysis of storm event antecedent dry weather period and initial losses data; calibration of the ET parameter in a continuous simulation model; use of the Thornthwaite ET formula; and direct laboratory measurement of evaporation. There appears to be potential to adapt the Thornthwaite ET formula to provide monthly ET estimates from local temperature data. The development of a standardized laboratory test for ET will enable differences resulting from substrate characteristics to be quantified.

  6. Comparison of in vitro flows past a mechanical heart valve in anatomical and axisymmetric aorta models

    Science.gov (United States)

    Haya, Laura; Tavoularis, Stavros

    2017-06-01

    Flow characteristics past a bileaflet mechanical heart valve were measured under physiological flow conditions in a straight tube with an axisymmetric expansion, similar to vessels used in previous studies, and in an anatomical model of the aorta. We found that anatomical features, including the three-lobed sinus and the aorta's curvature affected significantly the flow characteristics. The turbulent and viscous stresses were presented and discussed as indicators for potential blood damage and thrombosis. Both types of stresses, averaged over the two axial measurement planes, were significantly lower in the anatomical model than in the axisymmetric one. This difference was attributed to the lower height-to-width ratio and more gradual contraction of the anatomical aortic sinus. The curvature of the aorta caused asymmetries in the velocity and stress distributions during forward flow. Secondary flows resulting from the aorta's curvature are thought to have redistributed the fluid stresses transversely, resulting in a more homogeneous stress distribution in the anatomical aortic root than in the axisymmetric root. The results of this study demonstrate the importance of modelling accurately the aortic geometry in experimental and computational studies of prosthetic devices. Moreover, our findings suggest that grafts used for aortic root replacement should approximate as closely as possible the shape of the natural sinuses.

  7. Generic modelling framework for economic analysis of battery systems

    DEFF Research Database (Denmark)

    You, Shi; Rasmussen, Claus Nygaard

    2011-01-01

    for battery cycle life estimation, since the cycle life plays a central role in the economic analysis of BS. To illustrate the modelling framework, a case study using a Sodium Sulfur Battery (NAS) system with 5-minute regulating service is performed. The economic performances of two dispatch scenarios, a so...

  8. Non-generic couplings in supersymmetric standard models

    Directory of Open Access Journals (Sweden)

    Evgeny I. Buchbinder

    2015-09-01

    Full Text Available We study two phases of a heterotic standard model, obtained from a Calabi–Yau compactification of the E8×E8 heterotic string, in the context of the associated four-dimensional effective theories. In the first phase we have a standard model gauge group, an MSSM spectrum, four additional U(1 symmetries and singlet fields. In the second phase, obtained from the first by continuing along the singlet directions, three of the additional U(1 symmetries are spontaneously broken and the remaining one is a B–L symmetry. In this second phase, dimension five operators inducing proton decay are consistent with all symmetries and as such, they are expected to be present. We show that, contrary to this expectation, these operators are forbidden due to the additional U(1 symmetries present in the first phase of the model. We emphasise that such “unexpected” absences of operators, due to symmetry enhancement at specific loci in the moduli space, can be phenomenologically relevant and, in the present case, protect the model from fast proton decay.

  9. Generic Model Predictive Control Framework for Advanced Driver Assistance Systems

    NARCIS (Netherlands)

    Wang, M.

    2014-01-01

    This thesis deals with a model predictive control framework for control design of Advanced Driver Assistance Systems, where car-following tasks are under control. The framework is applied to design several autonomous and cooperative controllers and to examine the controller properties at the microsc

  10. Generic Model Predictive Control Framework for Advanced Driver Assistance Systems

    NARCIS (Netherlands)

    Wang, M.

    2014-01-01

    This thesis deals with a model predictive control framework for control design of Advanced Driver Assistance Systems, where car-following tasks are under control. The framework is applied to design several autonomous and cooperative controllers and to examine the controller properties at the microsc

  11. Half-trek criterion for generic identifiability of linear structural equation models

    CERN Document Server

    Foygel, Rina; Drton, Mathias

    2011-01-01

    A linear structural equation model relates random variables of interest and corresponding Gaussian noise terms via a linear equation system. Each such model can be represented by a mixed graph in which directed edges encode the linear equations, and bidirected edges indicate possible correlations among noise terms. We study parameter identifiability in these models, that is, we ask for conditions that ensure that the edge coefficients and correlations appearing in a linear structural equation model can be uniquely recovered from the covariance matrix of the associated normal distribution. We treat the case of generic identifiability, where unique recovery is possible for almost every choice of parameters. We give a new graphical criterion that is sufficient for generic identifiability. It improves criteria from prior work and does not require the directed part of the graph to be acyclic. We also develop a related necessary condition and examine the "gap" between sufficient and necessary conditions through sim...

  12. Chaos in Temperature in Generic 2 p-Spin Models

    Science.gov (United States)

    Panchenko, Dmitry

    2016-09-01

    We prove chaos in temperature for even p-spin models which include sufficiently many p-spin interaction terms. Our approach is based on a new invariance property for coupled asymptotic Gibbs measures, similar in spirit to the invariance property that appeared in the proof of ultrametricity in Panchenko (Ann Math (2) 177(1):383-393, 2013), used in combination with Talagrand's analogue of Guerra's replica symmetry breaking bound for coupled systems.

  13. Generic scaling relation in the scalar $\\phi^{4}$ model

    CERN Document Server

    Derkachov, S E

    1996-01-01

    The results of analysis of the one--loop spectrum of anomalous dimensions of composite operators in the scalar \\phi^{4} model are presented. We give the rigorous constructive proof of the hypothesis on the hierarchical structure of the spectrum of anomalous dimensions -- the naive sum of any two anomalous dimensions generates a limit point in the spectrum. Arguments in favor of the nonperturbative character of this result and the possible ways of a generalization to other field theories are briefly discussed.

  14. Development of a Generic Creep-Fatigue Life Prediction Model

    Science.gov (United States)

    Goswami, Tarun

    2002-01-01

    The objective of this research proposal is to further compile creep-fatigue data of steel alloys and superalloys used in military aircraft engines and/or rocket engines and to develop a statistical multivariate equation. The newly derived model will be a probabilistic fit to all the data compiled from various sources. Attempts will be made to procure the creep-fatigue data from NASA Glenn Research Center and other sources to further develop life prediction models for specific alloy groups. In a previous effort [1-3], a bank of creep-fatigue data has been compiled and tabulated under a range of known test parameters. These test parameters are called independent variables, namely; total strain range, strain rate, hold time, and temperature. The present research attempts to use these variables to develop a multivariate equation, which will be a probabilistic equation fitting a large database. The data predicted by the new model will be analyzed using the normal distribution fits, the closer the predicted lives are with the experimental lives (normal line 1 to 1 fit) the better the prediction. This will be evaluated in terms of a coefficient of correlation, R 2 as well. A multivariate equation developed earlier [3] has the following form, where S, R, T, and H have specific meaning discussed later.

  15. Dark matter direct detection rate in a generic model with micrOMEGAs2.2

    OpenAIRE

    Belanger, G.; Boudjema, F.; Pukhov, A.; Semenov, A.

    2008-01-01

    We present a new module of the micrOMEGAs package for the calculation of WIMP-nuclei elastic scattering cross sections relevant for the direct detection of dark matter through its interaction with nuclei in a large detector. With this new module, the computation of the direct detection rate is performed automatically for a generic model of new physics which contains a WIMP candidate. This model needs to be implemented within micrOMEGAs2.1.

  16. On Tachyons in Generic Orbifolds of $\\BC^r$ and Gauged Linear Sigma Models

    OpenAIRE

    Sarkar, Tapobrata

    2006-01-01

    We study some aspects of Gauged Linear Sigma Models corresponding to orbifold singularities of the form $\\BC^r/\\Gamma$, for $r=2,3$ and $\\Gamma = \\BZ_n$ and $\\BZ_n\\times \\BZ_m$. These orbifolds might be tachyonic in general. We compute expressions for the multi parameter sigma model Lagrangians for these orbifolds, in terms of their toric geometry data. Using this, we analyze some aspects of the phases of generic orbifolds of $\\BC^r$.

  17. Generic inference of inflation models by local non-Gaussianity

    CERN Document Server

    Dorn, Sebastian; Kunze, Kerstin E; Hofmann, Stefan; Enßlin, Torsten A

    2014-01-01

    The presence of multiple fields during inflation might seed a detectable amount of non-Gaussianity in the curvature perturbations, which in turn becomes observable in present data sets like the cosmic microwave background (CMB) or the large scale structure (LSS). Within this proceeding we present a fully analytic method to infer inflationary parameters from observations by exploiting higher-order statistics of the curvature perturbations. To keep this analyticity, and thereby to dispense with numerically expensive sampling techniques, a saddle-point approximation is introduced whose precision has been validated for a numerical toy example. Applied to real data, this approach might enable to discriminate among the still viable models of inflation.

  18. A generic 3D kinetic model of gene expression

    Science.gov (United States)

    Zhdanov, Vladimir

    2012-04-01

    Recent experiments show that mRNAs and proteins can be localized both in prokaryotic and eukaryotic cells. To describe such situations, I present a 3D mean-field kinetic model aimed primarily at gene expression in prokaryotic cells, including the formation of mRNA, its translation into protein, and slow diffusion of these species. Under steady-state conditions, the mRNA and protein spatial distribution is described by simple exponential functions. The protein concentration near the gene transcribed into mRNA is shown to depend on the protein and mRNA diffusion coefficients and degradation rate constants.

  19. Generic modelling framework for economic analysis of battery systems

    DEFF Research Database (Denmark)

    You, Shi; Rasmussen, Claus Nygaard

    2011-01-01

    Deregulated electricity markets provide opportunities for Battery Systems (BS) to participate in energy arbitrage and ancillary services (regulation, operating reserves, contingency reserves, voltage regulation, power quality etc.). To evaluate the economic viability of BS with different business...... for battery cycle life estimation, since the cycle life plays a central role in the economic analysis of BS. To illustrate the modelling framework, a case study using a Sodium Sulfur Battery (NAS) system with 5-minute regulating service is performed. The economic performances of two dispatch scenarios, a so...

  20. Implementation of IEC Generic Model of Type 1 Wind Turbine Generator in DIgSILENT PowerFactory

    DEFF Research Database (Denmark)

    Zhao, Haoran; Wu, Qiuwei; Margaris, Ioannis;

    2013-01-01

    The implementation method for the International Electrotechnical Commission (IEC) generic models of Type 1 wind turbine generator (WTG) in DIgSILENT PowerFactory is presented. The following items are described, i.e. model structure, model blocks and how to implement these blocks in the Power......Factory environment. Case studies under both normal and fault conditions are done with the implemented IEC generic models of Type 1 WTG, and dynamic responses are captured and analyzed. The case study results show that the IEC generic models of Type 1 WTG can correctly represent the performances of Type 1 WTG under...

  1. Implementation of IEC Generic Models of Type 1 Wind Turbine Generator in DIgSILENT PowerFactory

    Institute of Scientific and Technical Information of China (English)

    Haoran ZHAO; Qiuwei WU; Ioannis MARGARIS; Poul S(O)RENSEN

    2013-01-01

    The implementation method for the International Electrotechnical Commission (IEC) generic models of Type 1 wind turbine generator (WTG) in DIgSILENT PowerFactory is presented.The following items are described,i.e.model structure,model blocks and how to implement these blocks in the PowerFactory environment.Case studies under both normal and fault conditions are done with the implemented IEC generic models of Type 1 WTG,and dynamic responses are captured and analyzed.The case study results show that the IEC generic models of Type 1 WTG can correctly represent the performances of Type 1 WTG under both normal and fault conditions.

  2. Hidden generic diversity in Neotropical birds: molecular and anatomical data support a new genus for the "Scytalopus"indigoticus species-group (Aves: Rhinocryptidae).

    Science.gov (United States)

    Maurício, Giovanni Nachtigall; Mata, Helena; Bornschein, Marcos Ricardo; Cadena, Carlos Daniel; Alvarenga, Herculano; Bonatto, Sandro L

    2008-10-01

    The genus Scytalopus is a species-rich and taxonomically complicated component of the Neotropical avian family Rhinocryptidae. Probably because Scytalopus is a superficially uniform assemblage, its monophyly has not been seriously questioned. We investigated phylogenetic relationships of a representative set of species in the genus using nuclear and mitochondrial DNA sequences as well as anatomical data, and provided the first test of its presumed monophyly by including in the analyses its hypothesized closest relatives (the genera Myornis, Eugralla, and Merulaxis) as well as most rhinocryptid genera. We found strong support for the paraphyly of the genus Scytalopus, with the Scytalopus indigoticus species-group forming a clade with Merulaxis. A well-supported clade including the genera Eugralla, Myornis, and the remaining Scytalopus was also recovered. Because these results were recovered independently and with strong support using mitochondrial and nuclear data, and were entirely consistent with anatomical data, we erect a new genus for the S.indigoticus species-group. These findings illustrate the importance of formally testing hypotheses of monophyly even for well-accepted groups of Neotropical birds.

  3. Generic model for tunable colloidal aggregation in multidirectional fields.

    Science.gov (United States)

    Kogler, Florian; Velev, Orlin D; Hall, Carol K; Klapp, Sabine H L

    2015-10-07

    Based on Brownian Dynamics computer simulations in two dimensions we investigate aggregation scenarios of colloidal particles with directional interactions induced by multiple external fields. To this end we propose a model which allows continuous change in the particle interactions from point-dipole-like to patchy-like (with four patches). We show that, as a result of this change, the non-equilibrium aggregation occurring at low densities and temperatures transforms from conventional diffusion-limited cluster aggregation (DLCA) to slippery DLCA involving rotating bonds; this is accompanied by a pronounced change of the underlying lattice structure of the aggregates from square-like to hexagonal ordering. Increasing the temperature we find a transformation to a fluid phase, consistent with results of a simple mean-field density functional theory.

  4. Experiments and Modeling in Support of Generic Salt Repository Science

    Energy Technology Data Exchange (ETDEWEB)

    Bourret, Suzanne Michelle [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Stauffer, Philip H. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Weaver, Douglas James [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Caporuscio, Florie Andre [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Otto, Shawn [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Boukhalfa, Hakim [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Jordan, Amy B. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Chu, Shaoping [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Zyvoloski, George Anthony [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Johnson, Peter Jacob [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2017-01-19

    Salt is an attractive material for the disposition of heat generating nuclear waste (HGNW) because of its self-sealing, viscoplastic, and reconsolidation properties (Hansen and Leigh, 2012). The rate at which salt consolidates and the properties of the consolidated salt depend on the composition of the salt, including its content in accessory minerals and moisture, and the temperature under which consolidation occurs. Physicochemical processes, such as mineral hydration/dehydration salt dissolution and precipitation play a significant role in defining the rate of salt structure changes. Understanding the behavior of these complex processes is paramount when considering safe design for disposal of heat-generating nuclear waste (HGNW) in salt formations, so experimentation and modeling is underway to characterize these processes. This report presents experiments and simulations in support of the DOE-NE Used Fuel Disposition Campaign (UFDC) for development of drift-scale, in-situ field testing of HGNW in salt formations.

  5. VOODB: A Generic Discrete-Event Random Simulation Model to Evaluate the Performances of OODBs

    CERN Document Server

    Darmont, Jérôme

    1999-01-01

    Performance of object-oriented database systems (OODBs) is still an issue to both designers and users nowadays. The aim of this paper is to propose a generic discrete-event random simulation model, called VOODB, in order to evaluate the performances of OODBs in general, and the performances of optimization methods like clustering in particular. Such optimization methods undoubtedly improve the performances of OODBs. Yet, they also always induce some kind of overhead for the system. Therefore, it is important to evaluate their exact impact on the overall performances. VOODB has been designed as a generic discrete-event random simulation model by putting to use a modelling approach, and has been validated by simulating the behavior of the O2 OODB and the Texas persistent object store. Since our final objective is to compare object clustering algorithms, some experiments have also been conducted on the DSTC clustering technique, which is implemented in Texas. To validate VOODB, performance results obtained by si...

  6. Spatiotemporal dynamics of two generic predator-prey models.

    Science.gov (United States)

    Garvie, Marcus R; Trenchea, C

    2010-11-01

    We present the analysis of two reaction-diffusion systems modelling predator-prey interactions, where the predator displays the Holling type II functional response, and in the absence of predators, the prey growth is logistic. The local analysis is based on the application of qualitative theory for ordinary differential equations and dynamical systems, while the global well-posedness depends on invariant sets and differential inequalities. The key result is an L(∞)-stability estimate, which depends on a polynomial growth condition for the kinetics. The existence of an a priori L(p)-estimate, uniform in time, for all p ≥ 1, implies L(∞)-uniform bounds, given any nonnegative L(∞)-initial data. The applicability of the L(∞)-estimate to general reaction-diffusion systems is discussed, and how the continuous results can be mimicked in the discrete case, leading to stability estimates for a Galerkin finite-element method with piecewise linear continuous basis functions. In order to verify the biological wave phenomena of solutions, numerical results are presented in two-space dimensions, which have interesting ecological implications as they demonstrate that solutions can be 'trapped' in an invariant region of phase space.

  7. A generic hydrological model for a green roof drainage layer.

    Science.gov (United States)

    Vesuviano, Gianni; Stovin, Virginia

    2013-01-01

    A rainfall simulator of length 5 m and width 1 m was used to supply constant intensity and largely spatially uniform water inflow events to 100 different configurations of commercially available green roof drainage layer and protection mat. The runoff from each inflow event was collected and sampled at one-second intervals. Time-series runoff responses were subsequently produced for each of the tested configurations, using the average response of three repeat tests. Runoff models, based on storage routing (dS/dt = I-Q) and a power-law relationship between storage and runoff (Q = kS(n)), and incorporating a delay parameter, were created. The parameters k, n and delay were optimized to best fit each of the runoff responses individually. The range and pattern of optimized parameter values was analysed with respect to roof and event configuration. An analysis was performed to determine the sensitivity of the shape of the runoff profile to changes in parameter values. There appears to be potential to consolidate values of n by roof slope and drainage component material.

  8. 3D active workspace of human hand anatomical model

    Directory of Open Access Journals (Sweden)

    Ungureanu Loredana

    2007-05-01

    Full Text Available Abstract Background If the model of the human hand is created with accuracy by respecting the type of motion provided by each articulation and the dimensions of articulated bones, it can function as the real organ providing the same motions. Unfortunately, the human hand is hard to model due to its kinematical chains submitted to motion constraints. On the other hand, if an application does not impose a fine manipulation it is not necessary to create a model as complex as the human hand is. But always the hand model has to perform a certain space of motions in imposed workspace architecture no matter what the practical application does. Methods Based on Denavit-Hartenberg convention, we conceived the kinematical model of the human hand, having in mind the structure and the behavior of the natural model. We obtained the kinematical equations describing the motion of every fingertip with respect to the general coordinate system, placed on the wrist. For every joint variable, a range of motion was established. Dividing these joint variables to an appropriate number of intervals and connecting them, the complex surface bordering the active hand model workspace was obtained. Results Using MATLAB 7.0, the complex surface described by fingertips, when hand articulations are all simultaneously moving, was obtained. It can be seen that any point on surface has its own coordinates smaller than the maximum length of the middle finger in static position. Therefore, a sphere having the centre in the origin of the general coordinate system and the radius which equals this length covers the represented complex surface. Conclusion We propose a human hand model that represents a new solution compared to the existing ones. This model is capable to make special movements like power grip and dexterous manipulations. During them, the fingertips do not exceed the active workspace encapsulated by determined surfaces. The proposed kinematical model can help to choose

  9. Chinese adult anatomical models and the application in evaluation of RF exposures

    Science.gov (United States)

    Wu, Tongning; Tan, Liwen; Shao, Qing; Zhang, Chen; Zhao, Chen; Li, Ying; Conil, Emmanuelle; Hadjem, Abdelhamid; Wiart, Joe; Lu, Bingsong; Xiao, Li; Wang, Nan; Xie, Yi; Zhang, Shaoxiang

    2011-04-01

    This paper presents the work of constructing Chinese adult anatomical models and their application in evaluation of radio frequency (RF) electromagnetic field exposures. The original dataset was obtained from photos of the sliced frozen cadavers from the Chinese Visible Human Project. Details of preparing the cadaver for slicing procedures which may influence the anatomical structures are discussed. Segmentation and reconstruction were performed mainly manually by experienced anatomists. The reconstructed models represent the average Chinese in their twenties and thirties. The finest resolution for the models is 1 × 1 × 1 mm3 with 90 identified tissues/organs for the female and 87 identified tissues/organs for the male. Tiny anatomical structures such as blood vessels with diameters of 1 mm, various glands and nerves were identified. Whole-body-averaged specific absorption rate (WBSAR) from 20 MHz to 5.8 GHz was calculated with the finite-difference time-domain method for different RF exposure configurations. The WBSAR results are consistent with those from other available models. Finally, some details about the anatomical models are discussed.

  10. Experiment of Enzyme Kinetics Using Guided Inquiry Model for Enhancing Generic Science Skills

    Science.gov (United States)

    Amida, N.; Supriyanti, F. M. T.; Liliasari

    2017-02-01

    This study aims to enhance generic science skills of students using guided inquiry model through experiments of enzyme kinetics. This study used quasi-experimental methods, with pretest-posttestnonequivalent control group design. Subjects of this study were chemistry students enrolled in biochemistry lab course, consisted of 18 students in experimental class and 19 students in control class. Instrument in this study were essay test that involves 5 indicators of generic science skills (i.e. direct observation, causality, symbolic language, mathematical modeling, and concepts formation) and also student worksheets. The results showed that the experiments of kinetics enzyme using guided inquiry model have been enhance generic science skills in high category with a value of average of 0.77. Four indicators classified in the high category are direct observation, causality, symbolic language, and mathematical modeling with the value of 0,73 0,70; 0,96; dan 0,85. Meanwhile, indicator of concepts formation in the medium category with a value of 0.62

  11. FOSSIL2 energy policy model documentation: generic structures of the FOSSIL2 model

    Energy Technology Data Exchange (ETDEWEB)

    None

    1980-10-01

    This report discusses the structure, derivations, assumptions, and mathematical formulation of the FOSSIL2 model. Each major facet of the model - supply/demand interactions, industry financing, and production - has been designed to parallel closely the actual cause/effect relationships determining the behavior of the United States energy system. The data base for the FOSSIL2 program is large. When possible, all data were obtained from sources well known to experts in the energy field. Cost and resource estimates are based on DOE data whenever possible. This report presents the FOSSIL2 model at several levels. In Volume I, an overview of the basic structures, assumptions, and behavior of the FOSSIL2 model is presented so that the reader can understand the results of various policy tests. The discussion covers the three major building blocks, or generic structures, used to construct the model: supply/demand balance; finance and capital formation; and energy production. These structures reflect the components and interactions of the major processes within each energy industry that directly affect the dynamics of fuel supply, demand, and price within the energy system as a whole.

  12. Sparse Decomposition and Modeling of Anatomical Shape Variation

    DEFF Research Database (Denmark)

    Sjöstrand, Karl; Rostrup, Egill; Ryberg, Charlotte

    2007-01-01

    counterparts if constructed carefully. In most medical applications, models are required to have both good statistical performance and a relevant clinical interpretation to be of value. Morphometry of the corpus callosum is one illustrative example. This paper presents a method for relating spatial features...

  13. Improved constraints on primordial blackholes and gravitational waves for a generic model of inflation

    CERN Document Server

    Choudhury, Sayantan

    2014-01-01

    In this article we provide a new closed relationship between the cosmic abundance of primordial gravitational waves and primordial blackholes originated from initial inflationary perturbations for a generic model of inflation where inflation occurs below the Planck scale. We have obtained a strict bound on the current abundance of primordial blackholes from the Planck measurements, $9.99712\\times 10^{-3}<\\Omega_{PBH}h^{2}< 9.99736\\times 10^{-3}$.

  14. Fabrication and Assessment of 3D Printed Anatomical Models of the Lower Limb for Anatomical Teaching and Femoral Vessel Access Training in Medicine

    Science.gov (United States)

    O'Reilly, Michael K.; Reese, Sven; Herlihy, Therese; Geoghegan, Tony; Cantwell, Colin P.; Feeney, Robin N. M.; Jones, James F. X.

    2016-01-01

    For centuries, cadaveric dissection has been the touchstone of anatomy education. It offers a medical student intimate access to his or her first patient. In contrast to idealized artisan anatomical models, it presents the natural variation of anatomy in fine detail. However, a new teaching construct has appeared recently in which artificial…

  15. OPENICRA: Towards A Generic Model for Automatic Deployment of Applications in the Cloud Computing

    Directory of Open Access Journals (Sweden)

    Gadhgadhi Ridha

    2013-10-01

    Full Text Available This paper focuses on the design and the implementation of a new generic model for automated deployment of applications in the cloud to mitigate the effects of barriers to entry, reduce the complexity of application development and simplify the process of deploying cloud services. Our proposed model, called OpenICRA, implements a layered architecture that hides the implementation details, allowing having a simple deployment process. We conducted two real case studies to validate our proposed model. Our empirical results demonstrate the effectiveness of our proposed model to deploy different types of applications without any change in their source code.

  16. A Generic Role Based Access Control Model for Wind Power Systems

    DEFF Research Database (Denmark)

    Nagarajan, Anand; Jensen, Christian D.

    2010-01-01

    infrastructure in a software domain in a manufacturer independent manner as well as establishing secure communication and authenticating the other parties in electrical power infrastructures, but they do not address the problem of access control. We therefore propose a generic model for access control in wind...... power systems, which is based on the widely used role-based access control model. The proposed model is tested using a prototype designed in conformance with the standards that are in use in modern wind power infrastructure and the results are presented to determine the overhead in communication caused...... while adhering to the proposed access model....

  17. Supersymmetry breaking and gauge mediation in models with a generic superpotential

    Energy Technology Data Exchange (ETDEWEB)

    Kitano, Ryuichiro [Los Alamos National Laboratory; Ookouchi, Yutaka [CANADA

    2008-01-01

    In this note, we present a transparent scheme for finding or creating a (meta)stable vacuum in general supersymmetric models. We derive general conditions for having a supersymmetry breaking vacuum by connecting different models by a coordinate transformation, which is an application of the method used in [16]. In particular, we find that there can be a metastable supersymmetry breaking vacuum in models with the canonical Kahler potential and a generic superpotential. For example, the Wess-Zumino model coupled to the messenger fields possesses a metastable vacuum if coefficients of the superpotential terms satisfy certain inequalities.

  18. Simulating the spread of malaria using a generic transmission model for mosquito-borne infectious diseases

    Science.gov (United States)

    Kon, Cynthia Mui Lian; Labadin, Jane

    2016-06-01

    Malaria is a critical infection caused by parasites which are spread to humans through mosquito bites. Approximately half of the world's population is in peril of getting infected by malaria. Mosquito-borne diseases have a standard behavior where they are transmitted in the same manner, only through vector mosquito. Taking this into account, a generic spatial-temporal model for transmission of multiple mosquito-borne diseases had been formulated. Our interest is to reproduce the actual cases of different mosquito-borne diseases using the generic model and then predict future cases so as to improve control and target measures competently. In this paper, we utilize notified weekly malaria cases in four districts in Sarawak, Malaysia, namely Kapit, Song, Belaga and Marudi. The actual cases for 36 weeks, which is from week 39 in 2012 to week 22 in 2013, are compared with simulations of the generic spatial-temporal transmission mosquito-borne diseases model. We observe that the simulation results display corresponding result to the actual malaria cases in the four districts.

  19. The Parametric Model of the Human Mandible Coronoid Process Created by Method of Anatomical Features.

    Science.gov (United States)

    Vitković, Nikola; Mitić, Jelena; Manić, Miodrag; Trajanović, Miroslav; Husain, Karim; Petrović, Slađana; Arsić, Stojanka

    2015-01-01

    Geometrically accurate and anatomically correct 3D models of the human bones are of great importance for medical research and practice in orthopedics and surgery. These geometrical models can be created by the use of techniques which can be based on input geometrical data acquired from volumetric methods of scanning (e.g., Computed Tomography (CT)) or on the 2D images (e.g., X-ray). Geometrical models of human bones created in such way can be applied for education of medical practitioners, preoperative planning, etc. In cases when geometrical data about the human bone is incomplete (e.g., fractures), it may be necessary to create its complete geometrical model. The possible solution for this problem is the application of parametric models. The geometry of these models can be changed and adapted to the specific patient based on the values of parameters acquired from medical images (e.g., X-ray). In this paper, Method of Anatomical Features (MAF) which enables creation of geometrically precise and anatomically accurate geometrical models of the human bones is implemented for the creation of the parametric model of the Human Mandible Coronoid Process (HMCP). The obtained results about geometrical accuracy of the model are quite satisfactory, as it is stated by the medical practitioners and confirmed in the literature.

  20. Generic icing effects on forward flight performance of a model helicopter rotor

    Science.gov (United States)

    Tinetti, Ana F.; Korkan, Kenneth D.

    1989-01-01

    An experimental program using a commercially available model helicopter has been conducted in the TAMU 7 ft x 10 ft Subsonic Wind Tunnel to investigate main rotor performance degradation due to generic ice adhesion. Base and iced performance data were gathered as functions of fuselage incidence, blade collective pitch, main rotor rotational velocity, and freestream velocity. The experimental values have shown that, in general, the presence of generic ice introduces decrements in performance caused by leading edge separation regions and increased surface roughness. In addition to the expected changes in aerodynamic forces caused by variations in test Reynolds number, forward flight data seemed to be influenced by changes in freestream and rotational velocity. The dependence of the data upon such velocity variations was apparently enhanced by increases in blade chord.

  1. Generic icing effects on forward flight performance of a model helicopter rotor

    Science.gov (United States)

    Tinetti, Ana F.; Korkan, Kenneth D.

    1989-01-01

    An experimental program using a commercially available model helicopter has been conducted in the TAMU 7 ft x 10 ft Subsonic Wind Tunnel to investigate main rotor performance degradation due to generic ice adhesion. Base and iced performance data were gathered as functions of fuselage incidence, blade collective pitch, main rotor rotational velocity, and freestream velocity. The experimental values have shown that, in general, the presence of generic ice introduces decrements in performance caused by leading edge separation regions and increased surface roughness. In addition to the expected changes in aerodynamic forces caused by variations in test Reynolds number, forward flight data seemed to be influenced by changes in freestream and rotational velocity. The dependence of the data upon such velocity variations was apparently enhanced by increases in blade chord.

  2. Model of generic project risk element transmission theory based on data mining

    Institute of Scientific and Technical Information of China (English)

    LI Cun-bin; WANG Jian-jun

    2008-01-01

    In order to construct the data mining frame for the genetic project risk research, the basic definitions of the generic project risk element were given, and then a new model of the generic project risk element was presented with the definitions. From the model, data mining method was used to acquire the risk transmission matrix from the historical databases analysis. The quantitative calculation problem among the generic project risk elements was solved. This method deals with well the risk element transmission problems with limited states. And in order to get the limited states, fuzzy theory was used to discrete the historical data in historical databases. In an example, the controlling risk degree is chosen as P(Rs≥2) ≤0.1, it means that the probability of risk state which is not less than 2 in project is not more than 0.1, the risk element R3 is chosen to control the project, respectively. The result shows that three risk element transmission matrix can be acquired in 4 risk elements, and the frequency histogram and cumulative frequency histogram of each risk element are also given.

  3. Tool-driven Design and Automated Parameterization for Real-time Generic Drivetrain Models

    Directory of Open Access Journals (Sweden)

    Schwarz Christina

    2015-01-01

    Full Text Available Real-time dynamic drivetrain modeling approaches have a great potential for development cost reduction in the automotive industry. Even though real-time drivetrain models are available, these solutions are specific to single transmission topologies. In this paper an environment for parameterization of a solution is proposed based on a generic method applicable to all types of gear transmission topologies. This enables tool-guided modeling by non- experts in the fields of mechanic engineering and control theory leading to reduced development and testing efforts. The approach is demonstrated for an exemplary automatic transmission using the environment for automated parameterization. Finally, the parameterization is validated via vehicle measurement data.

  4. Exploring the anatomical encoding of voice with a mathematical model of the vocal system.

    Science.gov (United States)

    Assaneo, M Florencia; Sitt, Jacobo; Varoquaux, Gael; Sigman, Mariano; Cohen, Laurent; Trevisan, Marcos A

    2016-11-01

    The faculty of language depends on the interplay between the production and perception of speech sounds. A relevant open question is whether the dimensions that organize voice perception in the brain are acoustical or depend on properties of the vocal system that produced it. One of the main empirical difficulties in answering this question is to generate sounds that vary along a continuum according to the anatomical properties the vocal apparatus that produced them. Here we use a mathematical model that offers the unique possibility of synthesizing vocal sounds by controlling a small set of anatomically based parameters. In a first stage the quality of the synthetic voice was evaluated. Using specific time traces for sub-glottal pressure and tension of the vocal folds, the synthetic voices generated perceptual responses, which are indistinguishable from those of real speech. The synthesizer was then used to investigate how the auditory cortex responds to the perception of voice depending on the anatomy of the vocal apparatus. Our fMRI results show that sounds are perceived as human vocalizations when produced by a vocal system that follows a simple relationship between the size of the vocal folds and the vocal tract. We found that these anatomical parameters encode the perceptual vocal identity (male, female, child) and show that the brain areas that respond to human speech also encode vocal identity. On the basis of these results, we propose that this low-dimensional model of the vocal system is capable of generating realistic voices and represents a novel tool to explore the voice perception with a precise control of the anatomical variables that generate speech. Furthermore, the model provides an explanation of how auditory cortices encode voices in terms of the anatomical parameters of the vocal system.

  5. Anatomically realistic multiscale models of normal and abnormal gastrointestinal electrical activity.

    Science.gov (United States)

    Cheng, Leo K; Komuro, Rie; Austin, Travis M; Buist, Martin L; Pullan, Andrew J

    2007-03-01

    One of the major aims of the International Union of Physiological Sciences (IUPS) Physiome Project is to develop multiscale mathematical and computer models that can be used to help understand human health. We present here a small facet of this broad plan that applies to the gastrointestinal system. Specifically, we present an anatomically and physiologically based modelling framework that is capable of simulating normal and pathological electrical activity within the stomach and small intestine. The continuum models used within this framework have been created using anatomical information derived from common medical imaging modalities and data from the Visible Human Project. These models explicitly incorporate the various smooth muscle layers and networks of interstitial cells of Cajal (ICC) that are known to exist within the walls of the stomach and small bowel. Electrical activity within individual ICCs and smooth muscle cells is simulated using a previously published simplified representation of the cell level electrical activity. This simulated cell level activity is incorporated into a bidomain representation of the tissue, allowing electrical activity of the entire stomach or intestine to be simulated in the anatomically derived models. This electrical modelling framework successfully replicates many of the qualitative features of the slow wave activity within the stomach and intestine and has also been used to investigate activity associated with functional uncoupling of the stomach.

  6. Anatomically realistic multiscale models of normal and abnormal gastrointestinal electrical activity

    Institute of Scientific and Technical Information of China (English)

    Leo K Cheng; Rie Komuro; Travis M Austin; Martin L Buist; Andrew J Pullan

    2007-01-01

    One of the major aims of the Tnternational Union of Physiological Sciences (IUPS) Physiome Project is to develop multiscale mathematical and computer models that can be used to help understand human health.We present here a small facet of this broad plan that applies to the gastrointestinal system. Specifically,we present an anatomically and physiologically based modelling framework that is capable of simulating normal and pathological electrical activity within the stomach and small intestine. The continuum models used within this framework have been created using anatomical information derived from common medical imaging modalities and data from the Visible Human Project. These models explicitly incorporate the various smooth muscle layers and networks of interstitial cells of Cajal (ICC) that are known to exist within the walls of the stomach and small bowel. Electrical activity within individual ICCs and smooth muscle cells is simulated using a previously published simplified representation of the cell level electrical activity. This simulated cell level activity is incorporated into a bidomain representation of the tissue, allowing electrical activity of the entire stomach or intestine to be simulated in the anatomically derived models. This electrical modelling framework successfully replicates many of the qualitative features of the slow wave activity within the stomach and intestine and has also been used to investigate activity associated with functional uncoupling of the stomach.

  7. TRAVELING WAVES IN A BIOLOGICAL REACTION-DIFFUSION MODEL WITH STRONG GENERIC DELAY KERNEL AND NON-LOCAL EFFECT

    Institute of Scientific and Technical Information of China (English)

    2012-01-01

    In this paper,we consider the reaction diffusion equations with strong generic delay kernel and non-local effect,which models the microbial growth in a flow reactor.The existence of traveling waves is established for this model.More precisely,using the geometric singular perturbation theory,we show that traveling wave solutions exist provided that the delay is sufficiently small with the strong generic delay kernel.

  8. Studying PMMA films on silica surfaces with generic microscopic and mesoscale models

    Science.gov (United States)

    Zhang, J.; Mukherji, D.; Daoulas, K. Ch.

    2016-07-01

    Polymer films on solid substrates present significant interest for fundamental polymer physics and industrial applications. For their mesoscale study, we develop a hybrid particle-based representation where polymers are modeled as worm-like chains and non-bonded interactions are introduced through a simple density functional. The mesoscale description is parameterized to match a generic microscopic model, which nevertheless can represent real materials. Choosing poly (methyl methacrylate) adsorbed on silica as a case study, the consistency of both models in describing conformational and structural properties in polymer films is investigated. We compare selected quantifiers of chain-shape, the structure of the adsorbed layer, as well as the statistics of loops, tails, and trains. Overall, the models are found to be consistent with each other. Some deviations in conformations and structure of adsorbed layer can be attributed to the simplified description of polymer/surface interactions and local liquid packing in the mesoscale model. These results are encouraging for a future development of pseudo-dynamical schemes, parameterizing the kinetics in the hybrid model via the dynamics of the generic microscopic model.

  9. Generic feature of future crossing of phantom divide in viable $f(R)$ gravity models

    CERN Document Server

    Bamba, Kazuharu; Lee, Chung-Chi

    2010-01-01

    We study the equation of state for dark energy and explicitly demonstrate that the future crossings of the phantom divide line $w_{\\mathrm{DE}}=-1$ are the generic feature in the existing viable $f(R)$ gravity models. We also explore the future evolution of the cosmological horizon entropy and illustrate that the cosmological horizon entropy oscillates with time due to the oscillatory behavior of the Hubble parameter. The important cosmological consequence is that in the future, the sign of the time derivative of the Hubble parameter changes from negative to positive in these viable $f(R)$ gravity models.

  10. Generic feature of future crossing of phantom divide in viable f(R) gravity models

    Energy Technology Data Exchange (ETDEWEB)

    Bamba, Kazuharu; Geng, Chao-Qiang; Lee, Chung-Chi, E-mail: bamba@phys.nthu.edu.tw, E-mail: geng@phys.nthu.edu.tw, E-mail: g9522545@oz.nthu.edu.tw [Department of Physics, National Tsing Hua University, No. 101, Section 2, Kuang Fu Road, Hsinchu, Taiwan (China)

    2010-11-01

    We study the equation of state for dark energy and explicitly demonstrate that the future crossings of the phantom divide line w{sub DE} = −1 are the generic feature in the existing viable f(R) gravity models. We also explore the future evolution of the cosmological horizon entropy and illustrate that the cosmological horizon entropy oscillates with time due to the oscillatory behavior of the Hubble parameter. The important cosmological consequence is that in the future, the sign of the time derivative of the Hubble parameter changes from negative to positive in these viable f(R) gravity models.

  11. Explore or Exploit? A Generic Model and an Exactly Solvable Case

    Science.gov (United States)

    Gueudré, Thomas; Dobrinevski, Alexander; Bouchaud, Jean-Philippe

    2014-02-01

    Finding a good compromise between the exploitation of known resources and the exploration of unknown, but potentially more profitable choices, is a general problem, which arises in many different scientific disciplines. We propose a stylized model for these exploration-exploitation situations, including population or economic growth, portfolio optimization, evolutionary dynamics, or the problem of optimal pinning of vortices or dislocations in disordered materials. We find the exact growth rate of this model for treelike geometries and prove the existence of an optimal migration rate in this case. Numerical simulations in the one-dimensional case confirm the generic existence of an optimum.

  12. A generic model for estimating biomass accumulation and greenhouse gas emissions from perennial crops

    Science.gov (United States)

    Ledo, Alicia; Heathcote, Richard; Hastings, Astley; Smith, Pete; Hillier, Jonathan

    2017-04-01

    Agriculture is essential to maintain humankind but is, at the same time, a substantial emitter of greenhouse gas (GHG) emissions. With a rising global population, the need for agriculture to provide secure food and energy supply is one of the main human challenges. At the same time, it is the only sector which has significant potential for negative emissions through the sequestration of carbon and offsetting via supply of feedstock for energy production. Perennial crops accumulate carbon during their lifetime and enhance organic soil carbon increase via root senescence and decomposition. However, inconsistency in accounting for this stored biomass undermines efforts to assess the benefits of such cropping systems when applied at scale. A consequence of this exclusion is that efforts to manage this important carbon stock are neglected. Detailed information on carbon balance is crucial to identify the main processes responsible for greenhouse gas emissions in order to develop strategic mitigation programs. Perennial crops systems represent 30% in area of total global crop systems, a considerable amount to be ignored. Furthermore, they have a major standing both in the bioenergy and global food industries. In this study, we first present a generic model to calculate the carbon balance and GHGs emissions from perennial crops, covering both food and bioenergy crops. The model is composed of two simple process-based sub-models, to cover perennial grasses and other perennial woody plants. The first is a generic individual based sub-model (IBM) covering crops in which the yield is the fruit and the plant biomass is an unharvested residue. Trees, shrubs and climbers fall into this category. The second model is a generic area based sub-model (ABM) covering perennial grasses, in which the harvested part includes some of the plant parts in which the carbon storage is accounted. Most second generation perennial bioenergy crops fall into this category. Both generic sub-models

  13. On tachyons in generic orbifolds of C{sup r} and gauged linear sigma models

    Energy Technology Data Exchange (ETDEWEB)

    Sarkar, Tapobrata [Department of Physics, Indian Institute of Technology, Kanpur 208016 (India)

    2007-02-15

    We study some aspects of Gauged Linear Sigma Models corresponding to orbifold singularities of the form C{sup r}/{gamma}, for r = 2,3 and {gamma} = Z{sub n} and Z{sub n} x Z{sub m}. These orbifolds might be tachyonic in general. We compute expressions for the multi parameter sigma model Lagrangians for these orbifolds, in terms of their toric geometry data. Using this, we analyze some aspects of the phases of generic orbifolds of C{sup r}.

  14. Lagrangian theory of structure formation in relativistic cosmology II: average properties of a generic evolution model

    CERN Document Server

    Buchert, Thomas; Wiegand, Alexander

    2013-01-01

    Kinematical and dynamical properties of a generic inhomogeneous cosmological model, spatially averaged with respect to free-falling (generalized fundamental) observers, are investigated for the matter model `irrotational dust'. Paraphrasing a previous Newtonian investigation, we present a relativistic generalization of a backreaction model based on volume-averaging the `Relativistic Zel'dovich Approximation'. In this model we investigate the effect of `kinematical backreaction' on the evolution of cosmological parameters as they are defined in an averaged inhomogenous cosmology, and we show that the backreaction model interpolates between orthogonal symmetry properties by covering subcases of the plane-symmetric solution, the Lemaitre-Tolman-Bondi solution and the Szekeres solution. We so obtain a powerful model that lays the foundations for quantitatively addressing curvature inhomogeneities as they would be interpreted as `Dark Energy' or `Dark Matter' in a quasi-Newtonian cosmology. The present model, havi...

  15. Generic 2-D River Network Modeling of Flow and Sediment Transports

    Science.gov (United States)

    Guo, W.; Wang, C.; Xiang, X.; Ma, T.

    2012-04-01

    A generic 2D river network model of flow and sediment transports is proposed for the flow and sediment simulation in the complex river network. The paper expands the three-step method adopted in the 1D river network to the 2D river network simulation. A 2D river network model is divided into several cells, including single river cell, "tree-like" river cell, "ring-like" river cell and "cross-like" river cell, which can reflect the interactive influence of flow field in the bifurcated channel and applies to generic 2D simulation. Based on equation of the 2D shallow water and unsteady non-uniform suspended sediment, the relationship between the variables (water level, discharge and sediment concentration) of each section and those of the boundaries are obtained through the full implicit matrix chase-after method. Through the conservation of water and sediment on the boundaries, the water level and sediment concentration on the nodes can be got by solving the irregular sparse matrix of conservation equation, so as to implement the coupled simulation of flow and sediment in the whole river network. The paper take the Chengtong River Reach located in the low reaches of Yangtze River as the example of "cross-like" river to verify the algorithm. The model is calibrated using the measured data. A comparison of calculated water level, discharge and sediment concentration shows that the generic model can reflex the interactive influence of flow field, with reasonable accuracy, especially in the bifurcated channel.

  16. Quantitative model for the generic 3D shape of ICMEs at 1 AU

    Science.gov (United States)

    Démoulin, P.; Janvier, M.; Masías-Meza, J. J.; Dasso, S.

    2016-10-01

    Context. Interplanetary imagers provide 2D projected views of the densest plasma parts of interplanetary coronal mass ejections (ICMEs), while in situ measurements provide magnetic field and plasma parameter measurements along the spacecraft trajectory, that is, along a 1D cut. The data therefore only give a partial view of the 3D structures of ICMEs. Aims: By studying a large number of ICMEs, crossed at different distances from their apex, we develop statistical methods to obtain a quantitative generic 3D shape of ICMEs. Methods: In a first approach we theoretically obtained the expected statistical distribution of the shock-normal orientation from assuming simple models of 3D shock shapes, including distorted profiles, and compared their compatibility with observed distributions. In a second approach we used the shock normal and the flux rope axis orientations together with the impact parameter to provide statistical information across the spacecraft trajectory. Results: The study of different 3D shock models shows that the observations are compatible with a shock that is symmetric around the Sun-apex line as well as with an asymmetry up to an aspect ratio of around 3. Moreover, flat or dipped shock surfaces near their apex can only be rare cases. Next, the sheath thickness and the ICME velocity have no global trend along the ICME front. Finally, regrouping all these new results and those of our previous articles, we provide a quantitative ICME generic 3D shape, including the global shape of the shock, the sheath, and the flux rope. Conclusions: The obtained quantitative generic ICME shape will have implications for several aims. For example, it constrains the output of typical ICME numerical simulations. It is also a base for studying the transport of high-energy solar and cosmic particles during an ICME propagation as well as for modeling and forecasting space weather conditions near Earth.

  17. Validation of Generic Models for Variable Speed Operation Wind Turbines Following the Recent Guidelines Issued by IEC 61400-27

    Directory of Open Access Journals (Sweden)

    Andrés Honrubia-Escribano

    2016-12-01

    Full Text Available Considerable efforts are currently being made by several international working groups focused on the development of generic, also known as simplified or standard, wind turbine models for power system stability studies. In this sense, the first edition of International Electrotechnical Commission (IEC 61400-27-1, which defines generic dynamic simulation models for wind turbines, was published in February 2015. Nevertheless, the correlations of the IEC generic models with respect to specific wind turbine manufacturer models are required by the wind power industry to validate the accuracy and corresponding usability of these standard models. The present work conducts the validation of the two topologies of variable speed wind turbines that present not only the largest market share, but also the most technological advances. Specifically, the doubly-fed induction machine and the full-scale converter (FSC topology are modeled based on the IEC 61400-27-1 guidelines. The models are simulated for a wide range of voltage dips with different characteristics and wind turbine operating conditions. The simulated response of the IEC generic model is compared to the corresponding simplified model of a wind turbine manufacturer, showing a good correlation in most cases. Validation error sources are analyzed in detail, as well. In addition, this paper reviews in detail the previous work done in this field. Results suggest that wind turbine manufacturers are able to adjust the IEC generic models to represent the behavior of their specific wind turbines for power system stability analysis.

  18. Particle Image Velocimetry Measurements in Anatomically-Accurate Models of the Mammalian Nasal Cavity

    Science.gov (United States)

    Rumple, C.; Richter, J.; Craven, B. A.; Krane, M.

    2012-11-01

    A summary of the research being carried out by our multidisciplinary team to better understand the form and function of the nose in different mammalian species that include humans, carnivores, ungulates, rodents, and marine animals will be presented. The mammalian nose houses a convoluted airway labyrinth, where two hallmark features of mammals occur, endothermy and olfaction. Because of the complexity of the nasal cavity, the anatomy and function of these upper airways remain poorly understood in most mammals. However, recent advances in high-resolution medical imaging, computational modeling, and experimental flow measurement techniques are now permitting the study of airflow and respiratory and olfactory transport phenomena in anatomically-accurate reconstructions of the nasal cavity. Here, we focus on efforts to manufacture transparent, anatomically-accurate models for stereo particle image velocimetry (SPIV) measurements of nasal airflow. Challenges in the design and manufacture of index-matched anatomical models are addressed and preliminary SPIV measurements are presented. Such measurements will constitute a validation database for concurrent computational fluid dynamics (CFD) simulations of mammalian respiration and olfaction. Supported by the National Science Foundation.

  19. Efficient tunable generic model for self-assembling fluid bilayer membranes

    Science.gov (United States)

    Deserno, Markus

    2005-03-01

    We present a new model for the simulation of generic lipid bilayers in the mesoscopic regime (between a few nanometers and many tens of nanometers), which is very robust, versatile, and extremely efficient, since it avoids the need for an embedding solvent. Based entirely on simple pair potentials, it features a wide region of unassisted self assembly into fluid bilayers without the need for careful parameter tuning. The resulting membranes display the correct continuum elastic behavior with bending constants in the experimentally relevant range. It can be readily used to study events like bilayer fusion, bilayer melting, lipid mixtures, rafts, and protein-bilayer interactions.

  20. A comprehensive study of back-reaction and effective acceleration in generic LTB dust models

    CERN Document Server

    Sussman, Roberto A

    2011-01-01

    We provide a thorough examination of the conditions for the existence of back-reaction and an "effective" acceleration (in the context of Buchert's averaging formalism) in regular generic spherically symmetric Lemaitre-Tolman-Bondi (LTB) dust models. By considering arbitrary spherical comoving domains, we verify rigorously the fulfillment of these conditions expressed in terms of suitable scalar variables that are evaluated at the domains' boundaries. Effective deceleration necessarily occurs in all domains in: (a) the asymptotic radial range of models converging to a FLRW background, (b) the asymptotic time range of non-vacuum hyperbolic models, (c) LTB self-similar solutions and (d) near a simultaneous big bang. Accelerating domains are proven to exist in the following scenarios: (i) central vacuum regions, (ii) central (non-vacuum) density voids, (iii) the intermediate radial range of models converging to a FLRW background, (iv) the asymptotic radial range of models converging to a Minkowski vacuum and (v)...

  1. Combination of a model-deformation method and a positional MRI to quantify the effects of posture on the anatomical structures of the trunk.

    Science.gov (United States)

    Lafon, Y; Smith, F W; Beillas, P

    2010-05-07

    Understanding the postural effects on organs and skeleton could be crucial for several applications. This paper reports on a methodology to quantify the three-dimensional effects of postures on deformable anatomical structures. A positional MRI scanner was used to image the full trunk in four postures: supine, standing, seated and forward-flexed. The MRI stacks were processed with a custom toolbox, implemented using open source software. The semi-automated segmentation was based on the deformation of generic models of the pelvis, sternum, femoral heads, spine, liver, kidneys, spleen, skin, thoracic and abdominal cavities. The toolbox was designed to be easily extended by additional image filters, deformation schemes, or new generic models. Results obtained on one subject demonstrate that the method can be used to quantify the effects of postures on skeleton and organs. The spinal curvature, the pelvic parameters and the volume of the thoracic cavity were affected by the four postures. The volumes of the kidneys, spleen, liver and abdominal object were mostly unaffected. The movement of organs was coherent with the effect of gravity. The deformation of organs between postures was expressed using geometrical transformations. Investigations should be pursued on a larger population to confirm the patterns observed on the first subject. Copyright 2010 Elsevier Ltd. All rights reserved.

  2. Towards models of gravitational waveforms from generic binaries II: Modelling precession effects with a single effective precession parameter

    CERN Document Server

    Schmidt, Patricia; Hannam, Mark

    2014-01-01

    Gravitational waves (GWs) emitted by generic black-hole binaries show a rich structure that directly reflects the complex dynamics introduced by the precession of the orbital plane, which poses a real challenge to the development of generic waveform models. Recent progress in modelling these signals relies on an approximate decoupling between the non-precessing secular inspiral and a precession-induced rotation. However, the latter depends in general on all physical parameters of the binary which makes modelling efforts as well as understanding parameter-estimation prospects prohibitively complex. Here we show that the dominant precession effects can be captured by a reduced set of spin parameters. Specifically, we introduce a single \\emph{effective precession spin} parameter, $\\chi_p$, which is defined from the spin components that lie in the orbital plane at some (arbitrary) instant during the inspiral. We test the efficacy of this parameter by considering binary inspiral configurations specified by the phy...

  3. The generic simulation cell method for developing extensible, efficient and readable parallel computational models

    Science.gov (United States)

    Honkonen, I.

    2014-07-01

    I present a method for developing extensible and modular computational models without sacrificing serial or parallel performance or source code readability. By using a generic simulation cell method I show that it is possible to combine several distinct computational models to run in the same computational grid without requiring any modification of existing code. This is an advantage for the development and testing of computational modeling software as each submodel can be developed and tested independently and subsequently used without modification in a more complex coupled program. Support for parallel programming is also provided by allowing users to select which simulation variables to transfer between processes via a Message Passing Interface library. This allows the communication strategy of a program to be formalized by explicitly stating which variables must be transferred between processes for the correct functionality of each submodel and the entire program. The generic simulation cell class presented here requires a C++ compiler that supports variadic templates which were standardized in 2011 (C++11). The code is available at: https://github.com/nasailja/gensimcell for everyone to use, study, modify and redistribute; those that do are kindly requested to cite this work.

  4. The generic simulation cell method for developing extensible, efficient and readable parallel computational models

    Directory of Open Access Journals (Sweden)

    I. Honkonen

    2014-07-01

    Full Text Available I present a method for developing extensible and modular computational models without sacrificing serial or parallel performance or source code readability. By using a generic simulation cell method I show that it is possible to combine several distinct computational models to run in the same computational grid without requiring any modification of existing code. This is an advantage for the development and testing of computational modeling software as each submodel can be developed and tested independently and subsequently used without modification in a more complex coupled program. Support for parallel programming is also provided by allowing users to select which simulation variables to transfer between processes via a Message Passing Interface library. This allows the communication strategy of a program to be formalized by explicitly stating which variables must be transferred between processes for the correct functionality of each submodel and the entire program. The generic simulation cell class presented here requires a C++ compiler that supports variadic templates which were standardized in 2011 (C++11. The code is available at: https://github.com/nasailja/gensimcell for everyone to use, study, modify and redistribute; those that do are kindly requested to cite this work.

  5. A generic method for automatic translation between input models for different versions of simulation codes

    Energy Technology Data Exchange (ETDEWEB)

    Serfontein, Dawid E., E-mail: Dawid.Serfontein@nwu.ac.za [School of Mechanical and Nuclear Engineering, North West University (PUK-Campus), PRIVATE BAG X6001 (Internal Post Box 360), Potchefstroom 2520 (South Africa); Mulder, Eben J. [School of Mechanical and Nuclear Engineering, North West University (South Africa); Reitsma, Frederik [Calvera Consultants (South Africa)

    2014-05-01

    A computer code was developed for the semi-automatic translation of input models for the VSOP-A diffusion neutronics simulation code to the format of the newer VSOP 99/05 code. In this paper, this algorithm is presented as a generic method for producing codes for the automatic translation of input models from the format of one code version to another, or even to that of a completely different code. Normally, such translations are done manually. However, input model files, such as for the VSOP codes, often are very large and may consist of many thousands of numeric entries that make no particular sense to the human eye. Therefore the task, of for instance nuclear regulators, to verify the accuracy of such translated files can be very difficult and cumbersome. This may cause translation errors not to be picked up, which may have disastrous consequences later on when a reactor with such a faulty design is built. Therefore a generic algorithm for producing such automatic translation codes may ease the translation and verification process to a great extent. It will also remove human error from the process, which may significantly enhance the accuracy and reliability of the process. The developed algorithm also automatically creates a verification log file which permanently record the names and values of each variable used, as well as the list of meanings of all the possible values. This should greatly facilitate reactor licensing applications.

  6. A generic material flow control model applied in two industrial sectors

    NARCIS (Netherlands)

    Haneyah, S.W.A.; Schuur, Peter; Schutten, Johannes M.J.; Zijm, Willem H.M.

    2013-01-01

    This paper addresses the problem of generic planning and control of automated material handling systems (AMHSs). We build upon previous work to provide a proof of concept for generic control of AMHSs in different domains. We present a generic control architecture for AMHSs, and apply this

  7. Generic linking of finite element models for non-linear static and global dynamic analyses for aircraft structures

    NARCIS (Netherlands)

    Wit, de A.J.; Akcay Perdahcioglu, D.; Brink, van den W.M.; Boer, de A.

    2011-01-01

    Depending on the type of analysis, Finite Element(FE) models of different fidelity are necessary. Creating these models manually is a labor intensive task. This paper discusses a generic approach for generating FE models of different fidelity from a single reference FE model. These different fidelit

  8. Generic Linking of Finite Element Models for non-linear static and global dynamic analyses of aircraft structures

    NARCIS (Netherlands)

    Wit, de A.J.; Akcay-Perdahcioglu, D.; Brink, van den W.M.; Boer, de A.

    2012-01-01

    Depending on the type of analysis, Finite Element(FE) models of different fidelity are necessary. Creating these models manually is a labor intensive task. This paper discusses a generic approach for generating FE models of different fidelity from a single reference FE model. These different fidelit

  9. Generic linking of finite element models for non-linear static and global dynamic analyses for aircraft structures

    NARCIS (Netherlands)

    de Wit, A.J.; Akcay-Perdahcioglu, Didem; van den Brink, W.M.; de Boer, Andries; Rolfes, R.; Jansen, E.L.

    2011-01-01

    Depending on the type of analysis, Finite Element(FE) models of different fidelity are necessary. Creating these models manually is a labor intensive task. This paper discusses a generic approach for generating FE models of different fidelity from a single reference FE model. These different

  10. Generic Energy Matching Model and Figure of Matching Algorithm for Combined Renewable Energy Systems

    Directory of Open Access Journals (Sweden)

    J.C. Brezet

    2009-08-01

    Full Text Available In this paper the Energy Matching Model and Figure of Matching Algorithm which originally was dedicated only to photovoltaic (PV systems [1] are extended towards a Model and Algorithm suitable for combined systems which are a result of integration of two or more renewable energy sources into one. The systems under investigation will range from mobile portable devices up to the large renewable energy system conceivably to be applied at the Afsluitdijk (Closure- dike in the north of the Netherlands. This Afsluitdijk is the major dam in the Netherlands, damming off the Zuiderzee, a salt water inlet of the North Sea and turning it into the fresh water lake of the IJsselmeer. The energy chain of power supplies based on a combination of renewable energy sources can be modeled by using one generic Energy Matching Model as starting point.

  11. Generic framework for mining cellular automata models on protein-folding simulations.

    Science.gov (United States)

    Diaz, N; Tischer, I

    2016-05-13

    Cellular automata model identification is an important way of building simplified simulation models. In this study, we describe a generic architectural framework to ease the development process of new metaheuristic-based algorithms for cellular automata model identification in protein-folding trajectories. Our framework was developed by a methodology based on design patterns that allow an improved experience for new algorithms development. The usefulness of the proposed framework is demonstrated by the implementation of four algorithms, able to obtain extremely precise cellular automata models of the protein-folding process with a protein contact map representation. Dynamic rules obtained by the proposed approach are discussed, and future use for the new tool is outlined.

  12. Generic Energy Matching Model and Figure of Matching Algorithm for Combined Renewable Energy Systems

    Directory of Open Access Journals (Sweden)

    S. Y. Kan

    2009-08-01

    Full Text Available In this paper the Energy Matching Model and Figure of Matching Algorithm which originally was dedicated only to photovoltaic (PV systems [1] are extended towards a Model and Algorithm suitable for combined systems which are a result of integration of two or more renewable energy sources into one. The systems under investigation will range from mobile portable devices up to the large renewable energy system conceivably to be applied at the Afsluitdijk (Closure- dike in the north of the Netherlands. This Afsluitdijk is the major dam in the Netherlands, damming off the Zuiderzee, a salt water inlet of the North Sea and turning it into the fresh water lake of the IJsselmeer. The energy chain of power supplies based on a combination of renewable energy sources can be modeled by using one generic Energy Matching Model as starting point.

  13. a Generic Probabilistic Model and a Hierarchical Solution for Sensor Localization in Noisy and Restricted Conditions

    Science.gov (United States)

    Ji, S.; Yuan, X.

    2016-06-01

    A generic probabilistic model, under fundamental Bayes' rule and Markov assumption, is introduced to integrate the process of mobile platform localization with optical sensors. And based on it, three relative independent solutions, bundle adjustment, Kalman filtering and particle filtering are deduced under different and additional restrictions. We want to prove that first, Kalman filtering, may be a better initial-value supplier for bundle adjustment than traditional relative orientation in irregular strips and networks or failed tie-point extraction. Second, in high noisy conditions, particle filtering can act as a bridge for gap binding when a large number of gross errors fail a Kalman filtering or a bundle adjustment. Third, both filtering methods, which help reduce the error propagation and eliminate gross errors, guarantee a global and static bundle adjustment, who requires the strictest initial values and control conditions. The main innovation is about the integrated processing of stochastic errors and gross errors in sensor observations, and the integration of the three most used solutions, bundle adjustment, Kalman filtering and particle filtering into a generic probabilistic localization model. The tests in noisy and restricted situations are designed and examined to prove them.

  14. Simplified three-dimensional model provides anatomical insights in lizards' caudal autotomy as printed illustration

    Directory of Open Access Journals (Sweden)

    JOANA D.C.G. DE AMORIM

    2015-03-01

    Full Text Available Lizards' caudal autotomy is a complex and vastly employed antipredator mechanism, with thorough anatomic adaptations involved. Due to its diminished size and intricate structures, vertebral anatomy is hard to be clearly conveyed to students and researchers of other areas. Three-dimensional models are prodigious tools in unveiling anatomical nuances. Some of the techniques used to create them can produce irregular and complicated forms, which despite being very accurate, lack didactical uniformity and simplicity. Since both are considered fundamental characteristics for comprehension, a simplified model could be the key to improve learning. The model here presented depicts the caudal osteology of Tropidurus itambere, and was designed to be concise, in order to be easily assimilated, yet complete, not to compromise the informative aspect. The creation process requires only basic skills in manipulating polygons in 3D modeling softwares, in addition to the appropriate knowledge of the structure to be modeled. As reference for the modeling, we used microscopic observation and a photograph database of the caudal structures. This way, no advanced laboratory equipment was needed and all biological materials were preserved for future research. Therefore, we propose a wider usage of simplified 3D models both in the classroom and as illustrations for scientific publications.

  15. A Model of a Generic Natural Language Interface for Querying Database

    Directory of Open Access Journals (Sweden)

    Hanane Bais

    2016-02-01

    Full Text Available Extracting information from database is typically done by using a structured language such as SQL (Structured Query Language. But non expert users can’t use this later. Wherefore using Natural Language (NL for communicating with database can be a powerful tool. But without any help, computers can’t understand this language; that is why it is essential to develop an interface able to translate user’s query given in NL into an equivalent one in Database Query Language (DBQL. This paper presents a model of a generic natural language query interface for querying database. This model is based on machine learning approach which allows interface to automatically improve its knowledge base through experience. The advantage of this interface is that it functions independently of the database language, content and model. Experimentations are realized to study the performance of this interface and make necessary corrections for its amelioration

  16. An economic evaluation of photovoltaic grid connected systems (PVGCS) in Flanders for companies: A generic model

    Energy Technology Data Exchange (ETDEWEB)

    Audenaert, Amaryllis [Artesis Hogeschool Antwerpen, Paardenmarkt 92, 2000 Antwerp (Belgium); Universiteit Antwerpen, Faculty of Applied Economics, Prinsstraat 13, 2000 Antwerp (Belgium); De Boeck, Liesje [HUBrussel, Center for Modeling and Simulation, Stormstraat 2, 1000 Brussels (Belgium); Affiliated Researcher Katholieke Universiteit Leuven, Faculty of Business and Economics, Research Center for Operations Management, Naamsestraat 69, 3000 Leuven (Belgium); De Cleyn, Sven [Universiteit Antwerpen, Faculty of Applied Economics, Prinsstraat 13, 2000 Antwerp (Belgium); Lizin, Sebastien [Student UGent, Faculty of Bioscience Engineering, Coupure Links 653, 9000 Ghent (Belgium); Adam, Jean-Francois [Euroclear, Koning Albert II-laan 1, 1210 Brussels (Belgium)

    2010-12-15

    In this paper an economic evaluation of photovoltaic grid connected systems (PVGCS) for companies situated in Flanders (Belgium) is conducted by using a generic Excel model. The model is unique in that it includes the dimension of taxation. This inclusion is required, otherwise the fiscal benefit of using solar panels is not accounted for. The model uses the cash flow projection method. This technique allows the calculation of the following classical evaluation criteria: net present value, internal rate of return, payback period, discounted payback period, profitability index, yield unit cost, yield unit revenue and break-even turnkey cost. Their outcome makes it possible to answer the question whether installing a PVGCS in Flanders is a responsible financial investment for companies. Furthermore, the paper estimates whether the corporate environment is ready for a subsidy legislation change. This change has recently been announced and as such it is possible to gauge whether the current market situation is profitable given future legislation. (author)

  17. Theoretical Evaluation of the Sediment/Water Exchange Description in Generic Compartment Models (SimpleBox)

    DEFF Research Database (Denmark)

    Sørensen, P. B.; Fauser, P.; Carlsen, L.;

    It is shown how diffusion and deposition of solids drive the flux of substance between the water column and the sediment. The generic compartment models (Mackay type) use a one box model for the sediment in order to keep the calculations simple. However, when diffusion needs to be included...... in the calculations, the one box model needs to be evaluated in relation to a more complete solution of the differential equations for diffusion. General guidelines that are based on the system parameters are set up in order to establish the importance of diffusion and deposition respectively. These define the range...... where diffusion or deposition is negligible or where both processes must be included in order to describe the sediment-water substance exchange most appropriately....

  18. BasinBox: a generic multimedia fate model for predicting the fate of chemicals in river catchments

    NARCIS (Netherlands)

    Hollander, A; Huijbregts, M A J; Ragas, A M J; Meent, D van de

    2006-01-01

    Multimedia fate models have proven to be very useful tools in chemical risk assessment and management. This paper presents BasinBox, a newly developed steady-state generic multimedia fate model for evaluating risks of new and existing chemicals in river basins. The model concepts, as well as the int

  19. Anatomical features for an adequate choice of experimental animal model in biomedicine: II. Small laboratory rodents, rabbit, and pig.

    Science.gov (United States)

    Lossi, Laura; D'Angelo, Livia; De Girolamo, Paolo; Merighi, Adalberto

    2016-03-01

    The anatomical features distinctive to each of the very large array of species used in today's biomedical research must be born in mind when considering the correct choice of animal model(s), particularly when translational research is concerned. In this paper we take into consideration and discuss the most important anatomical and histological features of the commonest species of laboratory rodents (rat, mouse, guinea pig, hamster, and gerbil), rabbit, and pig related to their importance for applied research.

  20. Accounting for anatomical noise in search-capable model observers for planar nuclear imaging.

    Science.gov (United States)

    Sen, Anando; Gifford, Howard C

    2016-01-01

    Model observers intended to predict the diagnostic performance of human observers should account for the effects of both quantum and anatomical noise. We compared the abilities of several visual-search (VS) and scanning Hotelling-type models to account for anatomical noise in a localization receiver operating characteristic (LROC) study involving simulated nuclear medicine images. Our VS observer invoked a two-stage process of search and analysis. The images featured lesions in the prostate and pelvic lymph nodes. Lesion contrast and the geometric resolution and sensitivity of the imaging collimator were the study variables. A set of anthropomorphic mathematical phantoms was imaged with an analytic projector based on eight parallel-hole collimators with different sensitivity and resolution properties. The LROC study was conducted with human observers and the channelized nonprewhitening, channelized Hotelling (CH) and VS model observers. The CH observer was applied in a "background-known-statistically" protocol while the VS observer performed a quasi-background-known-exactly task. Both of these models were applied with and without internal noise in the decision variables. A perceptual search threshold was also tested with the VS observer. The model observers without inefficiencies failed to mimic the average performance trend for the humans. The CH and VS observers with internal noise matched the humans primarily at low collimator sensitivities. With both internal noise and the search threshold, the VS observer attained quantitative agreement with the human observers. Computational efficiency is an important advantage of the VS observer.

  1. Far field pacing supersedes anti-tachycardia pacing in a generic model of excitable media

    Energy Technology Data Exchange (ETDEWEB)

    Bittihn, Philip; Parlitz, Ulrich [Drittes Physikalisches Institut, Goettingen University, Friedrich-Hund-Platz 1, 37077 Goettingen (Germany); Luther, Gisela; Bodenschatz, Eberhard; Krinsky, Valentin; Luther, Stefan [Max Planck Institute for Dynamics and Self-Organization, Bunsenstrasse 10, 37073 Goettingen (Germany)], E-mail: bittihn@physik3.gwdg.de

    2008-10-15

    Removing anchored spirals from obstacles is an important step in terminating cardiac arrhythmia. Conventional anti-tachycardia pacing (ATP) has this ability, but only under very restrictive conditions. In a generic model of excitable media, we demonstrate that for unpinning spiral waves from obstacles this profound limitation of ATP can be overcome by far field pacing (FFP). More specifically, an argument is presented for why FFP includes and thus can only extend the capabilities of ATP in the configurations considered. By numerical simulations, we show that in the model there exists a parameter region in which unpinning is possible by FFP but not by ATP. The relevance of this result regarding clinical applications is discussed.

  2. Development of generic key performance indicators for PMBOK® using a 3D project integration model

    Directory of Open Access Journals (Sweden)

    Craig Langston

    2013-12-01

    Full Text Available Since Martin Barnes’ so-called ‘iron triangle’ circa 1969, much debate has occurred over how best to describe the fundamental constraints that underpin project success. This paper develops a 3D project integration model for PMBOK® comprising core constraints of scope, cost, time and risk as a basis to propose six generic key performance indicators (KPIs that articulate successful project delivery. These KPIs are defined as value, efficiency, speed, innovation, complexity and impact and can each be measured objectively as ratios of the core constraints. An overall KPI (denoted as s3/ctr is also derived. The aim in this paper is to set out the case for such a model and to demonstrate how it can be employed to assess the performance of project teams in delivering successful outcomes at various stages in the project life cycle. As part of the model’s development, a new PMBOK® knowledge area concerning environmental management is advanced.

  3. Quantitative model for the generic 3D shape of ICMEs at 1 AU

    CERN Document Server

    Démoulin, P; Masías-Meza, J J; Dasso, S

    2016-01-01

    Interplanetary imagers provide 2D projected views of the densest plasma parts of interplanetary coronal mass ejections (ICMEs) while in situ measurements provide magnetic field and plasma parameter measurements along the spacecraft trajectory, so along a 1D cut. As such, the data only give a partial view of their 3D structures. By studying a large number of ICMEs, crossed at different distances from their apex, we develop statistical methods to obtain a quantitative generic 3D shape of ICMEs. In a first approach we theoretically obtain the expected statistical distribution of the shock-normal orientation from assuming simple models of 3D shock shapes, including distorted profiles, and compare their compatibility with observed distributions. In a second approach we use the shock normal and the flux rope axis orientations, as well as the impact parameter, to provide statistical information across the spacecraft trajectory. The study of different 3D shock models shows that the observations are compatible with a ...

  4. The role of fine-scale anatomical structure in the dynamics of reentry in computational models of the rabbit ventricles.

    Science.gov (United States)

    Bishop, Martin J; Plank, Gernot

    2012-09-15

    Fine-scale anatomical structures in the heart may play an important role in sustaining cardiac arrhythmias. However, the extent of this role and how it may differ between species are not fully understood. In this study we used computational modelling to assess the impact of anatomy upon arrhythmia maintenance in the rabbit ventricles. Specifically, we quantified the dynamics of excitation wavefronts during episodes of simulated tachyarrhythmias and fibrillatory arrhythmias, defined as being respectively characterised by relatively low and high spatio-temporal disorganisation.Two computational models were used: a highly anatomically detailed MR-derived rabbit ventricular model (representing vasculature, endocardial structures) and a simplified equivalent model, constructed from the same MR-data but lacking such fine-scale anatomical features. During tachyarrhythmias, anatomically complex and simplified models showed very similar dynamics; however, during fibrillatory arrhythmias, as activation wavelength decreased, the presence of fine-scale anatomical details appeared to marginally increase disorganisation of wavefronts during arrhythmias in the complex model. Although a small amount of clustering of reentrant rotor centres (filaments) around endocardial structures was witnessed in follow-up analysis (which slightly increased during fibrillation as rotor size decreased), this was significantly less than previously reported in large animals. Importantly, no anchoring of reentrant rotors was visibly identifiable in arrhythmia movies. These differences between tachy- and fibrillatory arrhythmias suggest that the relative size of reentrant rotors with respect to anatomical obstacles governs the influence of fine-scale anatomy in the maintenance of ventricular arrhythmias in the rabbit. In conclusion, our simulations suggest that fine-scale anatomical features play little apparent role in the maintenance of tachyarrhythmias in the rabbit ventricles and, contrary to

  5. Nasal high flow clears anatomical dead space in upper airway models

    Science.gov (United States)

    Celik, Gülnaz; Feng, Sheng; Bartenstein, Peter; Meyer, Gabriele; Eickelberg, Oliver; Schmid, Otmar; Tatkov, Stanislav

    2015-01-01

    Recent studies showed that nasal high flow (NHF) with or without supplemental oxygen can assist ventilation of patients with chronic respiratory and sleep disorders. The hypothesis of this study was to test whether NHF can clear dead space in two different models of the upper nasal airways. The first was a simple tube model consisting of a nozzle to simulate the nasal valve area, connected to a cylindrical tube to simulate the nasal cavity. The second was a more complex anatomically representative upper airway model, constructed from segmented CT-scan images of a healthy volunteer. After filling the models with tracer gases, NHF was delivered at rates of 15, 30, and 45 l/min. The tracer gas clearance was determined using dynamic infrared CO2 spectroscopy and 81mKr-gas radioactive gamma camera imaging. There was a similar tracer-gas clearance characteristic in the tube model and the upper airway model: clearance half-times were below 1.0 s and decreased with increasing NHF rates. For both models, the anterior compartments demonstrated faster clearance levels (half-times clearance (half-times clearance in the models. For the anatomically based model, there was complete tracer-gas removal from the nasal cavities within 1.0 s. The level of clearance in the nasal cavities increased by 1.8 ml/s for every 1.0 l/min increase in the rate of NHF. The study has demonstrated the fast-occurring clearance of nasal cavities by NHF therapy, which is capable of reducing of dead space rebreathing. PMID:25882385

  6. Anatomical masking of pressure footprints based on the Oxford Foot Model: validation and clinical relevance.

    Science.gov (United States)

    Giacomozzi, Claudia; Stebbins, Julie A

    2017-03-01

    Plantar pressure analysis is widely used in the assessment of foot function. In order to assess regional loading, a mask is applied to the footprint to sub-divide it into regions of interest (ROIs). The most common masking method is based on geometric features of the footprint (GM). Footprint masking based on anatomical landmarks of the foot has been implemented more recently, and involves the integration of a 3D motion capture system, plantar pressure measurement device, and a multi-segment foot model. However, thorough validation of anatomical masking (AM) using pathological footprints has not yet been presented. In the present study, an AM method based on the Oxford Foot Model (OFM) was compared to an equivalent GM. Pressure footprints from 20 young healthy subjects (HG) and 20 patients with clubfoot (CF) were anatomically divided into 5 ROIs using a subset of the OFM markers. The same foot regions were also identified by using a standard GM method. Comparisons of intra-subject coefficient of variation (CV) showed that the OFM-based AM was at least as reliable as the GM for all investigated pressure parameters in all foot regions. Clinical relevance of AM was investigated by comparing footprints from HG and CF groups. Contact time, maximum force, force-time integral and contact area proved to be sensitive parameters that were able to distinguish HG and CF groups, using both AM and GM methods However, the AM method revealed statistically significant differences between groups in 75% of measured variables, compared to 62% using a standard GM method, indicating that the AM method is more sensitive for revealing differences between groups. Copyright © 2017 Elsevier B.V. All rights reserved.

  7. Implementation of draft IEC Generic Model of Type 1 Wind Turbine Generator in PowerFactory and Simulink

    DEFF Research Database (Denmark)

    Zhao, Haoran; Wu, Qiuwei; Sørensen, Poul Ejnar

    2013-01-01

    This paper presents the implementation work of IEC generic model of Type 1 wind turbine generator (WTG) in two commercial simulation tools: DIgSILENT PowerFactory (PF) and Matlab Simulink. The model topology, details of the composite blocks and implementation procedure in PF and Simulink...

  8. The analysis of a generic air-to-air missile simulation model

    Science.gov (United States)

    Kaplan, Joseph A.; Chappell, Alan R.; Mcmanus, John W.

    1994-01-01

    A generic missile model was developed to evaluate the benefits of using a dynamic missile fly-out simulation system versus a static missile launch envelope system for air-to-air combat simulation. This paper examines the performance of a launch envelope model and a missile fly-out model. The launch envelope model bases its probability of killing the target aircraft on the target aircraft's position at the launch time of the weapon. The benefits gained from a launch envelope model are the simplicity of implementation and the minimal computational overhead required. A missile fly-out model takes into account the physical characteristics of the missile as it simulates the guidance, propulsion, and movement of the missile. The missile's probability of kill is based on the missile miss distance (or the minimum distance between the missile and the target aircraft). The problems associated with this method of modeling are a larger computational overhead, the additional complexity required to determine the missile miss distance, and the additional complexity of determining the reason(s) the missile missed the target. This paper evaluates the two methods and compares the results of running each method on a comprehensive set of test conditions.

  9. Loads and Performance Data from a Wind-Tunnel Test of Generic Model Helicopter Rotor Blades

    Science.gov (United States)

    Yeager, William T., Jr.; Wilbur, Matthew L.

    2005-01-01

    An investigation was conducted in the NASA Langley Transonic Dynamics Tunnel to acquire data for use in assessing the ability of current and future comprehensive analyses to predict helicopter rotating-system and fixed-system vibratory loads. The investigation was conducted with a generic model helicopter rotor system using blades with rectangular planform, no built-in twist, uniform radial distribution of mass and stiffnesses, and a NACA 0012 airfoil section. Rotor performance data, as well as mean and vibratory components of blade bending and torsion moments, fixed-system forces and moments, and pitch link loads were obtained at advance ratios up to 0.35 for various combinations of rotor shaft angle-of-attack and collective pitch. The data are presented without analysis.

  10. Hierarchical statistical shape models of multiobject anatomical structures: application to brain MRI.

    Science.gov (United States)

    Cerrolaza, Juan J; Villanueva, Arantxa; Cabeza, Rafael

    2012-03-01

    The accurate segmentation of subcortical brain structures in magnetic resonance (MR) images is of crucial importance in the interdisciplinary field of medical imaging. Although statistical approaches such as active shape models (ASMs) have proven to be particularly useful in the modeling of multiobject shapes, they are inefficient when facing challenging problems. Based on the wavelet transform, the fully generic multiresolution framework presented in this paper allows us to decompose the interobject relationships into different levels of detail. The aim of this hierarchical decomposition is twofold: to efficiently characterize the relationships between objects and their particular localities. Experiments performed on an eight-object structure defined in axial cross sectional MR brain images show that the new hierarchical segmentation significantly improves the accuracy of the segmentation, and while it exhibits a remarkable robustness with respect to the size of the training set.

  11. Dark matter direct detection rate in a generic model with micrOMEGAs_2.2

    Science.gov (United States)

    Bélanger, G.; Boudjema, F.; Pukhov, A.; Semenov, A.

    2009-05-01

    We present a new module of the micrOMEGAs package for the calculation of WIMP-nuclei elastic scattering cross sections relevant for the direct detection of dark matter through its interaction with nuclei in a large detector. With this new module, the computation of the direct detection rate is performed automatically for a generic model of new physics which contains a WIMP candidate. This model needs to be implemented within micrOMEGAs 2.2. Program summaryProgram title: micrOMEGAs2.2 Catalogue identifier: ADQR_v2_2 Program summary URL:http://cpc.cs.qub.ac.uk/summaries/ADQR_v2_2.html Program obtainable from: CPC Program Library, Queen's University, Belfast, N. Ireland Licensing provisions: Standard CPC licence, http://cpc.cs.qub.ac.uk/licence/licence.html No. of lines in distributed program, including test data, etc.: 206 949 No. of bytes in distributed program, including test data, etc.: 2 245 230 Distribution format: tar.gz Programming language: C and Fortran Computer: PC, Alpha, Mac Operating system: UNIX (Linux, OSF1, Darwin, Cygwin) RAM: 17 MB depending on the number of processes required Classification: 1.9, 11.6 Catalogue identifier of previous version: ADQR_v2_1 Journal reference of previous version: Comput. Phys. Comm. 177 (2007) 894 Does the new version supersede the previous version?: Yes Nature of problem: Calculation of the relic density and of direct and indirect detection rates of the lightest stable particle in a generic new model of particle physics. Solution method: In numerically solving the evolution equation for the density of darkmatter, relativistic formulae for the thermal average are used. All tree-level processes for annihilation and coannihilation of new particles in the model are included. The cross-sections for all processes are calculated exactly with CalcHEP after definition of a model file. Higher-order QCD corrections to Higgs couplings to quark pairs are included. The coefficients of the effective Lagrangian which describes the

  12. On the performance of a generic length scale turbulence model within an adaptive finite element ocean model

    Science.gov (United States)

    Hill, Jon; Piggott, M. D.; Ham, David A.; Popova, E. E.; Srokosz, M. A.

    2012-10-01

    Research into the use of unstructured mesh methods for ocean modelling has been growing steadily in the last few years. One advantage of using unstructured meshes is that one can concentrate resolution where it is needed. In addition, dynamic adaptive mesh optimisation (DAMO) strategies allow resolution to be concentrated when this is required. Despite the advantage that DAMO gives in terms of improving the spatial resolution where and when required, small-scale turbulence in the oceans still requires parameterisation. A two-equation, generic length scale (GLS) turbulence model (one equation for turbulent kinetic energy and another for a generic turbulence length-scale quantity) adds this parameterisation and can be used in conjunction with adaptive mesh techniques. In this paper, an implementation of the GLS turbulence parameterisation is detailed in a non-hydrostatic, finite-element, unstructured mesh ocean model, Fluidity-ICOM. The implementation is validated by comparing to both a laboratory-scale experiment and real-world observations, on both fixed and adaptive meshes. The model performs well, matching laboratory and observed data, with resolution being adjusted as necessary by DAMO. Flexibility in the prognostic fields used to construct the error metric used in DAMO is required to ensure best performance. Moreover, the adaptive mesh models perform as well as fixed mesh models in terms of root mean square error to observation or theoretical mixed layer depths, but uses fewer elements and hence has a reduced computational cost.

  13. A three-dimensional musculoskeletal model for gait analysis. Anatomical variability estimates.

    Science.gov (United States)

    White, S C; Yack, H J; Winter, D A

    1989-01-01

    Three-dimensional coordinates defining the origin and insertion of 40 muscle units, and bony landmarks for osteometric scaling were identified on dry bone specimens. Interspecimen coordinate differences along the anterior-posterior axis of the pelvis and the long bone axes of the pelvis, femur and leg were reduced by scaling but landmark differences along the other axes were not. The coordinates were mapped to living subjects using close-range photogrammetry to locate superficial reference markers. The error of predicting the positions of internal coordinates was assessed by comparing joint centre locations calculated from local axes defining the orientation of segments superior and inferior to a joint. A difference was attributed to: anatomical variability not accounted for by scaling; errors in identifying and placing reference landmarks; the accuracy of locating markers using photogrammetry and error introduced by marker oscillation during movement. Anatomical differences between specimens are one source of error in defining a musculoskeletal model but larger errors are introduced when such models are mapped to living subjects.

  14. A guide to modelling cardiac electrical activity in anatomically detailed ventricles.

    Science.gov (United States)

    Clayton, R H; Panfilov, A V

    2008-01-01

    One of the most recent trends in cardiac electrophysiology is the development of integrative anatomically accurate models of the heart, which include description of cardiac activity from sub-cellular and cellular level to the level of the whole organ. In order to construct this type of model, a researcher needs to collect a wide range of information from books and journal articles on various aspects of biology, physiology, electrophysiology, numerical mathematics and computer programming. The aim of this methodological article is to survey recent developments in integrative modelling of electrical activity in the ventricles of the heart, and to provide a practical guide to the resources and tools that are available for work in this exciting and challenging area.

  15. Computed anatomical modelling of the optic pathway and oculomotor system using magnetic resonance imaging.

    Science.gov (United States)

    Juanes, J A; Ruisoto, P; Prats-Galino, A; Framiñán, A; Riesco, J M

    2014-07-01

    This study presents a computer-based tool for three-dimensional (3D) visualization of the optic pathway and oculomotor system using 3D high-resolution magnetic resonance imaging (MRI) datasets from a healthy subject. The 3D models were built as wireframe grids co-registered with MRI sections. First, 3D anatomical models were generated of the visual pathway from the eyeball to the primary visual cortex and of the cranial oculomotor nerves from the brain stem to the extrinsic eye muscles. Second, a graphical user interface allowed individual and group visualization, translation, rotation and zooming of the 3D models in different spatial positions simultaneously with MRI orthogonal cut planes. Educational and clinical applications are also discussed.

  16. A generic system dynamics model for simulating and evaluating the hydrological performance of reconstructed watersheds

    Directory of Open Access Journals (Sweden)

    N. Keshta

    2008-06-01

    Full Text Available The mining of oil sands in northern Alberta, Canada, involves the stripping and salvage of surface soil layers to gain access to the oil mines. The oil sands industry has committed to reconstructing these disturbed watersheds to replicate the performance of the natural soil horizons and to reproduce the various functions of natural watersheds. The selection of the texture and thickness of the reconstructed soil cover layers is based primarily on the concept that all covers must have sufficient moisture for vegetation over the growing season. Assessment of the hydrological performance of the reconstructed soil covers is crucial to select the best cover alternative. A generic system dynamics watershed (GSDW model is developed, based on the existing site-specific SDW model, and applied to five reconstructed watersheds located in the Athabasca mining basin, Alberta, Canada; and one natural watershed (boreal forest located in Saskatchewan, Canada; to simulate the various hydrological processes; in particular, soil moisture patterns and actual evapotranspiration, in reconstructed and natural watersheds. The model is capable of capturing the dynamics of the water balance components in both reconstructed and natural watersheds. The developed GSDW model provides a vital tool, which enables the investigation of the utility of different soil cover alternative designs and evaluation of their performance. Moreover, the model can be used to conduct short- and long- term predictions under different climate scenarios.

  17. Generic variation?

    DEFF Research Database (Denmark)

    Jensen, Torben Juel

    2009-01-01

    Abstract In modern Danish, a handful of pronouns may be used to refer to a generic referent. In recent decades, the second person singular pronoun du has gained ground, apparently in parallel to similar recent developments in other languages. Even though generic du may not be as old as the tradit...

  18. A Generic Integrated Physiologically based Whole-body Model of the Glucose-Insulin-Glucagon Regulatory System

    Science.gov (United States)

    Schaller, S; Willmann, S; Lippert, J; Schaupp, L; Pieber, T R; Schuppert, A; Eissing, T

    2013-01-01

    Models of glucose metabolism are a valuable tool for fundamental and applied medical research in diabetes. Use cases range from pharmaceutical target selection to automatic blood glucose control. Standard compartmental models represent little biological detail, which hampers the integration of multiscale data and confines predictive capabilities. We developed a detailed, generic physiologically based whole-body model of the glucose-insulin-glucagon regulatory system, reflecting detailed physiological properties of healthy populations and type 1 diabetes individuals expressed in the respective parameterizations. The model features a detailed representation of absorption models for oral glucose, subcutaneous insulin and glucagon, and an insulin receptor model relating pharmacokinetic properties to pharmacodynamic effects. Model development and validation is based on literature data. The quality of predictions is high and captures relevant observed inter- and intra-individual variability. In the generic form, the model can be applied to the development and validation of novel diabetes treatment strategies. PMID:23945606

  19. A generic tight-binding model for monolayer, bilayer and bulk MoS2

    Directory of Open Access Journals (Sweden)

    Ferdows Zahid

    2013-05-01

    Full Text Available Molybdenum disulfide (MoS2 is a layered semiconductor which has become very important recently as an emerging electronic device material. Being an intrinsic semiconductor the two-dimensional MoS2 has major advantages as the channel material in field-effect transistors. In this work we determine the electronic structures of MoS2 with the highly accurate screened hybrid functional within the density functional theory (DFT including the spin-orbit coupling. Using the DFT electronic structures as target, we have developed a single generic tight-binding (TB model that accurately produces the electronic structures for three different forms of MoS2 - bulk, bilayer and monolayer. Our TB model is based on the Slater-Koster method with non-orthogonal sp3d5 orbitals, nearest-neighbor interactions and spin-orbit coupling. The TB model is useful for atomistic modeling of quantum transport in MoS2 based electronic devices.

  20. A generic statistical model of hydride formation in a random alloy

    Science.gov (United States)

    Zhdanov, Vladimir P.

    2016-09-01

    Hydride formation in metals (e.g. in Pd), accompanied by a hysteresis loop in the absorption isotherms, is one of the generic examples of first-order phase transitions (FOPTs). During the last decade, the corresponding experimental studies, driven by applications related to hydrogen storage, have shifted towards metal particles sized from a few nanometers to micrometers in general and to alloyed particles of these sizes in particular. The understanding of hydride formation in alloys is, however, still far from complete. Herein, a statistical model of hydride formation in a random alloy is presented. The model is focused on the situation when this process is favorable in metal 1 (e.g. Pd) and shows what may happen when atoms of metal 2 make it less favorable due to decrease of the hydrogen binding energy and/or attractive hydrogen-hydrogen (H-H) interaction. Random distribution of metal atoms is taken explicitly into account. The attractive H-H interaction, including its dependence on fraction of metal 2 in the alloy, is described at the mean-field level. With increasing fraction of the latter metal, the critical temperature is found to decrease linearly or nonlinearly depending on the values of the model parameters. If the decrease of the hydrogen binding energy with increasing number of nearest-neighbor (nn) atoms of metal 2 is appreciable, the model predicts up to three hysteresis loops.

  1. Bioequivalence of generic drugs.

    Science.gov (United States)

    Andrade, Chittaranjan

    2015-09-01

    Generic drugs are bioequivalent to the original brand; this is a prerequisite for marketing approval. It is theoretically possible that one generic drug may overestimate the pharmacokinetic (PK) parameters of the original and another generic may underestimate these PK parameters; in consequence, these 2 generics may not be bioequivalent between themselves. The result could be loss of efficacy or development of drug-related adverse effects if these generics are interchanged in stable patients. In a recent study involving 292 indirect comparisons of generic formulations of 9 different drugs, mathematical modeling showed that in most cases (87.0% for maximum concentration, 90.1% for area under the curve, and 80.5% for both) generic drugs are bioequivalent to each other. These reassuring findings notwithstanding, prudence dictates that, in stable patients, generic drugs should be interchanged only if there is a good reason for it. This is because bioequivalent brands of drugs may differ in their excipient content, and this can result in variations in safety profiles.

  2. Surface mesh to voxel data registration for patient-specific anatomical modeling

    Science.gov (United States)

    de Oliveira, Júlia E. E.; Giessler, Paul; Keszei, András.; Herrler, Andreas; Deserno, Thomas M.

    2016-03-01

    Virtual Physiological Human (VPH) models are frequently used for training, planning, and performing medical procedures. The Regional Anaesthesia Simulator and Assistant (RASimAs) project has the goal of increasing the application and effectiveness of regional anesthesia (RA) by combining a simulator of ultrasound-guided and electrical nerve-stimulated RA procedures and a subject-specific assistance system through an integration of image processing, physiological models, subject-specific data, and virtual reality. Individualized models enrich the virtual training tools for learning and improving regional anaesthesia (RA) skills. Therefore, we suggest patient-specific VPH models that are composed by registering the general mesh-based models with patient voxel data-based recordings. Specifically, the pelvis region has been focused for the support of the femoral nerve block. The processing pipeline is composed of different freely available toolboxes such as MatLab, the open Simulation framework (SOFA), and MeshLab. The approach of Gilles is applied for mesh-to-voxel registration. Personalized VPH models include anatomical as well as mechanical properties of the tissues. Two commercial VPH models (Zygote and Anatomium) were used together with 34 MRI data sets. Results are presented for the skin surface and pelvic bones. Future work will extend the registration procedure to cope with all model tissue (i.e., skin, muscle, bone, vessel, nerve, fascia) in a one-step procedure and extrapolating the personalized models to body regions actually being out of the captured field of view.

  3. Evaluation of semi-generic PBTK modeling for emergency risk assessment after acute inhalation exposure to volatile hazardous chemicals

    NARCIS (Netherlands)

    Olie, J. Daniël N; Bessems, Jos G.; Clewell, Harvey J.; Meulenbelt, Jan; Hunault, Claudine C.

    2015-01-01

    BACKGROUND: Physiologically Based Toxicokinetic Models (PBTK) may facilitate emergency risk assessment after chemical incidents with inhalation exposure, but they are rarely used due to their relative complexity and skill requirements. We aimed to tackle this problem by evaluating a semi-generic PBT

  4. Geo-referenced multimedia environmental fate model (G-CIEMS): model formulation and comparison to the generic model and monitoring approaches.

    Science.gov (United States)

    Suzuki, Noriyuki; Murasawa, Kaori; Sakurai, Takeo; Nansai, Keisuke; Matsuhashi, Keisuke; Moriguchi, Yuichi; Tanabe, Kiyoshi; Nakasugi, Osami; Morita, Masatoshi

    2004-11-01

    A spatially resolved and geo-referenced dynamic multimedia environmental fate model, G-CIEMS (Grid-Catchment Integrated Environmental Modeling System) was developed on a geographical information system (GIS). The case study for Japan based on the air grid cells of 5 x 5 km resolution and catchments with an average area of 9.3 km2, which corresponds to about 40,000 air grid cells and 38,000 river segments/catchment polygons, were performed for dioxins, benzene, 1,3-butadiene, and di-(2-ethyhexyl)phthalate. The averaged concentration of the model and monitoring output were within a factor of 2-3 for all the media. Outputs from G-CIEMS and the generic model were essentially comparable when identical parameters were employed, whereas the G-CIEMS model gave explicit information of distribution of chemicals in the environment. Exposure-weighted averaged concentrations (EWAC) in air were calculated to estimate the exposure ofthe population, based on the results of generic, G-CIEMS, and monitoring approaches. The G-CIEMS approach showed significantly better agreement with the monitoring-derived EWAC than the generic model approach. Implication for the use of a geo-referenced modeling approach in the risk assessment scheme is discussed as a generic-spatial approach, which can be used to provide more accurate exposure estimation with distribution information, using generally available data sources for a wide range of chemicals.

  5. Enhancement of mobile C-arm cone-beam reconstruction using prior anatomical models

    Science.gov (United States)

    Sadowsky, Ofri; Lee, Junghoon; Sutter, Edward G.; Wall, Simon J.; Prince, Jerry L.; Taylor, Russell H.

    2009-02-01

    We demonstrate an improvement to cone-beam tomographic imaging by using a prior anatomical model. A protocol for scanning and reconstruction has been designed and implemented for a conventional mobile C-arm: a 9 inch image-intensifier OEC-9600. Due to the narrow field of view (FOV), the reconstructed image contains strong truncation artifacts. We propose to improve the reconstructed images by fusing the observed x-ray data with computed projections of a prior 3D anatomical model, derived from a subject-specific CT or from a statistical database (atlas), and co-registered (3D/2D) to the x-rays. The prior model contains a description of geometry and radiodensity as a tetrahedral mesh shape and density polynomials, respectively. A CT-based model can be created by segmentation, meshing and polynomial fitting of the object's CT study. The statistical atlas is created through principal component analysis (PCA) of a collection of mesh instances deformably-registered (3D/3D) to patient datasets. The 3D/2D registration method optimizes a pixel-based similarity score (mutual information) between the observed x-rays and the prior. The transformation involves translation, rotation and shape deformation based on the atlas. After registration, the image intensities of observed and prior projections are matched and adjusted, and the two information sources are blended as inputs to a reconstruction algorithm. We demonstrate recostruction results of three cadaveric specimens, and the effect of fusing prior data to compensate for truncation. Further uses of hybrid reconstruction, such as compensation for the scan's limited arc length, are suggested for future research.

  6. A generic interference model for uplink OFDMA networks with fractional frequency reuse

    KAUST Repository

    Tabassum, Hina

    2014-03-01

    Fractional frequency reuse (FFR) has emerged as a viable solution to coordinate and mitigate cochannel interference (CCI) in orthogonal frequency-division multiple-access (OFDMA)-based wireless cellular networks. The incurred CCI in cellular networks with FFR is highly uncertain and varies as a function of various design parameters that include the user scheduling schemes, the transmit power distribution among multiple allocated subcarriers, the partitioning of the cellular region into cell-edge and cell-center zones, the allocation of spectrum within each zone, and the channel reuse factors. To this end, this paper derives a generic analytical model for uplink CCI in multicarrier OFDMA networks with FFR. The derived expressions capture several network design parameters and are applicable to any composite fading-channel models. The accuracy of the derivations is verified via Monte Carlo simulations. Moreover, their usefulness is demonstrated by obtaining closed-form expressions for the Rayleigh fading-channel model and by evaluating important network performance metrics such as ergodic capacity. Numerical results provide useful system design guidelines and highlight the trade-offs associated with the deployment of FFR schemes in OFDMA-based networks. © 2013 IEEE.

  7. Block-sparse Lamb wave structural health monitoring using generic scattering models

    Science.gov (United States)

    Levine, Ross M.; Michaels, Jennifer E.

    2014-02-01

    A well-known damage detection paradigm is the use of ultrasonic guided waves that are generated and recorded by a spatially-distributed array of piezoelectric transducers. This type of configuration is capable of interrogating a defect from a variety of angles and over a large region of interest by analyzing all pairwise transducer signals. By subtracting prerecorded baseline signals, differential signals are obtained that can be analyzed for the purpose of detecting, locating, and characterizing newly-introduced scatterers. Typical analysis techniques such as delay-and-sum imaging have the ability to detect flaws, but their performance is limited, especially when the potential scatterers may have high directionality or introduce phase shifts. Signal envelopes are frequently used to avoid the problem of unknown phase shifts, which further reduces performance. The sparsity-based technique described here uses a different approach, where each potential damage location has its own generic linear scattering model that allows for unknown variations in amplitude and phase between each transducer pair. The differential signals are then assumed to be a linear combination of a small number of these models, and an image is generated using a block-sparse reconstruction algorithm that splits the signals into location-based components. Results are presented for experimental data. The images exhibit smaller spot size and fewer artifacts than those obtained via delay-and-sum imaging, provided the model is reasonably well-matched to the data.

  8. Numerical Modeling of Exhaust Smoke Dispersion for a Generic Frigate and Comparisons with Experiments

    Institute of Scientific and Technical Information of China (English)

    Selma Ergin; Erin Dobrucal

    2014-01-01

    The exhaust smoke dispersion for a generic frigate is investigated numerically through the numerical solution of the governing fluid flow, energy, species and turbulence equations. The main objective of this work is to obtain the effects of the yaw angle, velocity ratio and buoyancy on the dispersion of the exhaust smoke. The numerical method is based on the fully conserved control-volume representation of the fully elliptic Navier-Stokes equations. Turbulence is modeled using a two-equation (k-ε) model. The flow visualization tests using a 1/100 scale model of the frigate in the wind tunnel were also carried out to determine the exhaust plume path and to validate the computational results. The results show that down wash phenomena occurs for the yaw angles between ψ=10° and 20°. The results with different exhaust gas temperatures show that the buoyancy effect increases with the increasing of the exhaust gas temperature. However, its effect on the plume rise is less significant in comparison with its momentum. A good agreement between the predictions and experiment results is obtained.

  9. Specific and generic stem biomass and volume models of tree species in a West African tropical semi-deciduous forest

    DEFF Research Database (Denmark)

    Goussanou, Cédric A.; Guendehou, Sabin; Assogbadjo, Achille E.

    2016-01-01

    The quantification of the contribution of tropical forests to global carbon stocks and climate change mitigation requires availability of data and tools such as allometric equations. This study made available volume and biomass models for eighteen tree species in a semi-deciduous tropical forest...... in West Africa. Generic models were also developed for the forest ecosystem, and basic wood density determined for the tree species. Non-destructive sampling approach was carried out on five hundred and one sample trees to analyse stem volume and biomass. From the modelling of volume and biomass...... predictive ability for biomass. Given tree species richness of tropical forests, the study demonstrated the hypothesis that species-specific models are preferred to generic models, and concluded that further research should be oriented towards development of specific models to cover the full range...

  10. An anatomically shaped lower body model for CT scanning of cadaver femurs

    Energy Technology Data Exchange (ETDEWEB)

    Tanck, Esther; Deenen, J C W; Verdonschot, Nico [Orthopaedic Research Laboratory, Radboud University Nijmegen Medical Center, PO Box 9101, 6500 HB Nijmegen (Netherlands); Huisman, Henk Jan [Department of Radiology, Radboud University Nijmegen Medical Center, Nijmegen (Netherlands); Kooloos, Jan G [Department of Anatomy, Radboud University Nijmegen Medical Center, Nijmegen (Netherlands); Huizenga, Henk [Department of Radiotherapy, Radboud University Nijmegen Medical Center, Nijmegen (Netherlands)], E-mail: e.tanck@orthop.umcn.nl

    2010-01-21

    Bone specific, CT-based finite element (FE) analyses have great potential to accurately predict the fracture risk of deteriorated bones. However, it has been shown that differences exist between FE-models of femora scanned in a water basin or scanned in situ within the human body, as caused by differences in measured bone mineral densities (BMD). In this study we hypothesized that these differences can be reduced by re-creating the patient CT-conditions by using an anatomically shaped physical model of the lower body. BMD distributions were obtained from four different femora that were scanned under three conditions: (1) in situ within the cadaver body, (2) in a water basin and (3) in the body model. The BMD of the three scanning protocols were compared at two locations: proximally, in the trabecular bone of the femoral head, and in the cortical bone of the femoral shaft. Proximally, no significant differences in BMD were found between the in situ scans and the scans in the body model, whereas the densities from the water basin scans were on average 10.8% lower than in situ. In the femoral shaft the differences between the three scanning protocols were insignificant. In conclusion, the body model better approached the in situ situation than a water basin. Future studies can use this body model to mimic patient situations and to develop protocols to improve the performance of the FE-models in actual patients. (note)

  11. A Smart and Generic Secured Storage Model for Web based Systems

    Directory of Open Access Journals (Sweden)

    P.Iyappan

    2014-09-01

    Full Text Available Nowadays, Recent developments shows that, Cloud computing is a milestone in delivering IT services based on the Internet. Storage as a Service is a type of business model which rents storage space for smaller companies or even for individuals. The vendors are targeting secondary storage by promoting this service which allows a convenient way of managing backups instead of maintaining a large tape library. The key advantage of using Storage service is cost savings of hardware and physical storage spaces. In securing Storage as a Service model, there is a need for a middleware to monitor the data transmission among cloud storage and various clients. The objective of the system aims at developing a smart and integrated dynamic secured storage model which acts as a middleware in supporting all the primary security goals such as confidentiality, data integrity, and accountability. This proposed model will provide secured data dynamics, access controls and auditability. The secured data dynamics is done by Boneh Franklin-Identity Based Cryptography. This model enhances the accounting model in adding indexing policies and provides security in the audit logs through password based cryptography along with AES. This is a generic middleware assisting the basic security features for any cloud environment, so that it can be equipped for any type of system. The main advantage of the proposed system is to reduce the time complexity in encryption and decryption process and also to provide higher degree of security. We also leveraged the implementation of this middleware in a mail server environment with drive option which poses file storage and enables file sharing among the drive users.

  12. Development of an Anatomically Accurate Finite Element Human Ocular Globe Model for Blast-Related Fluid-Structure Interaction Studies

    Science.gov (United States)

    2017-02-01

    I, Eilaghi A, Portnoy S, Sled JG, Ethier CR. Dimensions of the human sclera: thickness measurement and regional changes with axial length. Exp Eye ...for throughout the development of this model. 2. Full Human Ocular Globe Model The full eye model is developed from averaged anatomic measures ...first model, a second-generation model was developed with an offset ONH, as shown in Fig 9. The anterior region of the eye model, up to the

  13. Dynamic Modeling & Stability Analysis of a Generic UAV in Glide Phase

    Directory of Open Access Journals (Sweden)

    Mir Imran

    2017-01-01

    Full Text Available In this paper, we present dynamic modelling and stability analysis of a generic UAV in the glide phase under engine failure condition. When such extreme phenomena occurs, the most desirable requirement is to survive that stage by keeping the vehicle controllable by maintaining its orientation and to glide the vehicle towards the intended direction with maximum extended range. This study investigates the stability aspects of one such aerial vehicle under engine failure condition. In the proposed architecture, a six degree of freedom vehicle dynamic simulation model is implemented through a set of coupled non-linear differential equations. The aerodynamic forces and moments encountered by the UAV during various phases of the flight are ascertained through empirical / non-empirical techniques. Non-linear constrained optimization technique is employed to evaluate the steady state values of the optimized trajectory for the complete flight regime. Results from dynamical systems theory are applied to investigate local stability characteristics of UAV around the steady state. Complete set of dynamic modes of UAV throughout the glide phase are evaluated and mode content in each of the motion variable is determined using modal decomposition technique. The dynamic characteristics of the open-loop configuration are assessed to generate adequate benchmark performance for closed-loop controller design

  14. Experimental study of UTM-LST generic half model transport aircraft

    Science.gov (United States)

    Ujang, M. I.; Mat, S.; Perumal, K.; Mohd. Nasir, M. N.

    2016-10-01

    This paper presents the experimental results from the investigation carried out at the UTM Low Speed wind tunnel facility (UTM-LST) on a half model generic transport aircraft at several configurations of primary control surfaces (flap, aileron and elevator). The objective is to measure the aerodynamic forces and moments due to the configuration changes. The study is carried out at two different speeds of 26.1 m/s and 43.1 m/s at corresponding Reynolds number of 1 × 106 and 2 × 106, respectively. Angle of attack of the model is varied between -2o to 20o. For the flaps, the deflection applied is 0o, 5o and 10o. Meanwhile, for aileron and elevator, the deflection applied is between -10o and 10o. The results show the differences in aerodynamic characteristics of the aircraft at different control surfaces configurations. The results obtained indicate that a laminar separation bubble developed on the surface of the wing at lower angles of attack and show that the separation process is delayed when the Reynolds number is increased.

  15. Clusterwise HICLAS: a generic modeling strategy to trace similarities and differences in multiblock binary data.

    Science.gov (United States)

    Wilderjans, T F; Ceulemans, E; Kuppens, P

    2012-06-01

    In many areas of the behavioral sciences, different groups of objects are measured on the same set of binary variables, resulting in coupled binary object × variable data blocks. Take, as an example, success/failure scores for different samples of testees, with each sample belonging to a different country, regarding a set of test items. When dealing with such data, a key challenge consists of uncovering the differences and similarities between the structural mechanisms that underlie the different blocks. To tackle this challenge for the case of a single data block, one may rely on HICLAS, in which the variables are reduced to a limited set of binary bundles that represent the underlying structural mechanisms, and the objects are given scores for these bundles. In the case of multiple binary data blocks, one may perform HICLAS on each data block separately. However, such an analysis strategy obscures the similarities and, in the case of many data blocks, also the differences between the blocks. To resolve this problem, we proposed the new Clusterwise HICLAS generic modeling strategy. In this strategy, the different data blocks are assumed to form a set of mutually exclusive clusters. For each cluster, different bundles are derived. As such, blocks belonging to the same cluster have the same bundles, whereas blocks of different clusters are modeled with different bundles. Furthermore, we evaluated the performance of Clusterwise HICLAS by means of an extensive simulation study and by applying the strategy to coupled binary data regarding emotion differentiation and regulation.

  16. From LCAs to simplified models: a generic methodology applied to wind power electricity.

    Science.gov (United States)

    Padey, Pierryves; Girard, Robin; le Boulch, Denis; Blanc, Isabelle

    2013-02-05

    This study presents a generic methodology to produce simplified models able to provide a comprehensive life cycle impact assessment of energy pathways. The methodology relies on the application of global sensitivity analysis to identify key parameters explaining the impact variability of systems over their life cycle. Simplified models are built upon the identification of such key parameters. The methodology is applied to one energy pathway: onshore wind turbines of medium size considering a large sample of possible configurations representative of European conditions. Among several technological, geographical, and methodological parameters, we identified the turbine load factor and the wind turbine lifetime as the most influent parameters. Greenhouse Gas (GHG) performances have been plotted as a function of these key parameters identified. Using these curves, GHG performances of a specific wind turbine can be estimated, thus avoiding the undertaking of an extensive Life Cycle Assessment (LCA). This methodology should be useful for decisions makers, providing them a robust but simple support tool for assessing the environmental performance of energy systems.

  17. Development of a Dynamically Scaled Generic Transport Model Testbed for Flight Research Experiments

    Science.gov (United States)

    Jordan, Thomas; Langford, William; Belcastro, Christine; Foster, John; Shah, Gautam; Howland, Gregory; Kidd, Reggie

    2004-01-01

    This paper details the design and development of the Airborne Subscale Transport Aircraft Research (AirSTAR) test-bed at NASA Langley Research Center (LaRC). The aircraft is a 5.5% dynamically scaled, remotely piloted, twin-turbine, swept wing, Generic Transport Model (GTM) which will be used to provide an experimental flight test capability for research experiments pertaining to dynamics modeling and control beyond the normal flight envelope. The unique design challenges arising from the dimensional, weight, dynamic (inertial), and actuator scaling requirements necessitated by the research community are described along with the specific telemetry and control issues associated with a remotely piloted subscale research aircraft. Development of the necessary operational infrastructure, including operational and safety procedures, test site identification, and research pilots is also discussed. The GTM is a unique vehicle that provides significant research capacity due to its scaling, data gathering, and control characteristics. By combining data from this testbed with full-scale flight and accident data, wind tunnel data, and simulation results, NASA will advance and validate control upset prevention and recovery technologies for transport aircraft, thereby reducing vehicle loss-of-control accidents resulting from adverse and upset conditions.

  18. Numerical Modeling of Geomechanical Processes Related to CO{sub 2} Injection within Generic Reservoirs

    Energy Technology Data Exchange (ETDEWEB)

    Eckert, Andreas

    2013-05-31

    In this project generic anticline structures have been used for numerical modeling analyses to study the influence of geometrical parameters, fluid flow boundary conditions, in situ stress regime and inter-bedding friction coefficient on geomechanical risks such as fracture reactivation and fracture generation. The resulting stress states for these structures are also used to determine safe drilling directions and a methodology for wellbore trajection optimization is developed that is applicable for non-Andersonian stress states. The results of the fluid flow simulation show that the type of fluid flow boundary condition is of utmost importance and has significant impact on all injection related parameters. It is recommended that further research is conducted to establish a method to quantify the fluid flow boundary conditions for injection applications. The results of the geomechanical simulation show that in situ stress regime is a crucial, if not the most important, factor determining geomechanical risks. For extension and strike slip stress regimes anticline structures should be favored over horizontally layered basin as they feature higher ΔP{sub c} magnitudes. If sedimentary basins are tectonically relaxed and their state of stress is characterized by the uni-axial strain model the basin is in exact frictional equilibrium and fluids should not be injected. The results also show that low inter bedding friction coefficients effectively decouple layers resulting in lower ΔP{sub c} magnitudes, especially for the compressional stress regime.

  19. The Kiel data management infrastructure - arising from a generic data model

    Science.gov (United States)

    Fleischer, D.; Mehrtens, H.; Schirnick, C.; Springer, P.

    2010-12-01

    The Kiel Data Management Infrastructure (KDMI) started from a cooperation of three large-scale projects (SFB574, SFB754 and Cluster of Excellence The Future Ocean) and the Leibniz Institute of Marine Sciences (IFM-GEOMAR). The common strategy for project data management is a single person collecting and transforming data according to the requirements of the targeted data center(s). The intention of the KDMI cooperation is to avoid redundant and potentially incompatible data management efforts for scientists and data managers and to create a single sustainable infrastructure. An increased level of complexity in the conceptual planing arose from the diversity of marine disciplines and approximately 1000 scientists involved. KDMI key features focus on the data provenance which we consider to comprise the entire workflow from field sampling thru labwork to data calculation and evaluation. Managing the data of each individual project participant in this way yields the data management for the entire project and warrants the reusability of (meta)data. Accordingly scientists provide a workflow definition of their data creation procedures resulting in their target variables. The central idea in the development of the KDMI presented here is based on the object oriented programming concept which allows to have one object definition (workflow) and infinite numbers of object instances (data). Each definition is created by a graphical user interface and produces XML output stored in a database using a generic data model. On creation of a data instance the KDMI translates the definition into web forms for the scientist, the generic data model then accepts all information input following the given data provenance definition. An important aspect of the implementation phase is the possibility of a successive transition from daily measurement routines resulting in single spreadsheet files with well known points of failure and limited reuseability to a central infrastructure as a

  20. Analysis of mouse model pathology: a primer for studying the anatomic pathology of genetically engineered mice.

    Science.gov (United States)

    Cardiff, Robert D; Miller, Claramae H; Munn, Robert J

    2014-06-02

    This primer of pathology is intended to introduce investigators to the structure (morphology) of cancer with an emphasis on genetically engineered mouse (GEM) models (GEMMs). We emphasize the necessity of using the entire biological context for the interpretation of anatomic pathology. Because the primary investigator is responsible for almost all of the information and procedures leading up to microscopic examination, they should also be responsible for documentation of experiments so that the microscopic interpretation can be rendered in context of the biology. The steps involved in this process are outlined, discussed, and illustrated. Because GEMMs are unique experimental subjects, some of the more common pitfalls are discussed. Many of these errors can be avoided with attention to detail and continuous quality assurance.

  1. Did pterosaurs feed by skimming? Physical modelling and anatomical evaluation of an unusual feeding method.

    Directory of Open Access Journals (Sweden)

    Stuart Humphries

    2007-08-01

    Full Text Available Similarities between the anatomies of living organisms are often used to draw conclusions regarding the ecology and behaviour of extinct animals. Several pterosaur taxa are postulated to have been skim-feeders based largely on supposed convergences of their jaw anatomy with that of the modern skimming bird, Rynchops spp. Using physical and mathematical models of Rynchops bills and pterosaur jaws, we show that skimming is considerably more energetically costly than previously thought for Rynchops and that pterosaurs weighing more than one kilogram would not have been able to skim at all. Furthermore, anatomical comparisons between the highly specialised skull of Rynchops and those of postulated skimming pterosaurs suggest that even smaller forms were poorly adapted for skim-feeding. Our results refute the hypothesis that some pterosaurs commonly used skimming as a foraging method and illustrate the pitfalls involved in extrapolating from limited morphological convergence.

  2. Understanding complex systems: lessons from Auzoux's and von Hagens's anatomical models

    Indian Academy of Sciences (India)

    Antonio G Valdecasas; Ana M Correas; Carmen R Guerrero; Jesús Juez

    2009-12-01

    Animal and human anatomy is among the most complex systems known, and suitable teaching methods have been of great importance in the progress of knowledge. Examining the human body is part of the process by which medical students come to understand living forms. However, the need to preserve cadavers has led to the development of various techniques to manufacture models for teaching purposes. A variety of materials, such as wax, wood, papier-mâché, or glass, have long been used to construct animal and plant models. In the case of the human body, the most innovative, yet controversial, method of preservation has been plastination, invented by the German physician Gunther von Hagens, by which actual human bodies are preserved as odourless and aesthetic models for teaching and exhibitions. We point out in our study that the ‘hands-on’ approach that some anatomical models allow, namely, the (clastic) disassembly and reassembly of the parts of complex systems and their models, is not only a crucial tool for learning, but is far superior to the simple passive observation that rigid, single-piece models allow. And what is valid for the learning of anatomy can be generalized to the acquisition of knowledge of other complex physical systems.

  3. Anatomical Reproducibility of a Head Model Molded by a Three-dimensional Printer.

    Science.gov (United States)

    Kondo, Kosuke; Nemoto, Masaaki; Masuda, Hiroyuki; Okonogi, Shinichi; Nomoto, Jun; Harada, Naoyuki; Sugo, Nobuo; Miyazaki, Chikao

    2015-01-01

    We prepared rapid prototyping models of heads with unruptured cerebral aneurysm based on image data of computed tomography angiography (CTA) using a three-dimensional (3D) printer. The objective of this study was to evaluate the anatomical reproducibility and accuracy of these models by comparison with the CTA images on a monitor. The subjects were 22 patients with unruptured cerebral aneurysm who underwent preoperative CTA. Reproducibility of the microsurgical anatomy of skull bone and arteries, the length and thickness of the main arteries, and the size of cerebral aneurysm were compared between the CTA image and rapid prototyping model. The microsurgical anatomy and arteries were favorably reproduced, apart from a few minute regions, in the rapid prototyping models. No significant difference was noted in the measured lengths of the main arteries between the CTA image and rapid prototyping model, but errors were noted in their thickness (p 3D printer. It was concluded that these models are useful tools for neurosurgical simulation. The thickness of the main arteries and size of cerebral aneurysm should be comprehensively judged including other neuroimaging in consideration of errors.

  4. Evaluation of an autoclave resistant anatomic nose model for the testing of nasal swabs.

    Science.gov (United States)

    Bartolitius, Lennart; Frickmann, Hagen; Warnke, Philipp; Ottl, Peter; Podbielski, Andreas

    2014-09-01

    A nose model that allows for the comparison of different modes of sample acquisition as well as of nasal swab systems concerning their suitability to detect defined quantities of intranasal microorganisms, and further for training procedures of medical staff, was evaluated. Based on an imprint of a human nose, a model made of a silicone elastomer was formed. Autoclave stability was assessed. Using an inoculation suspension containing Staphylococcus aureus and Staphylococcus epidermidis, the model was compared with standardized glass plate inoculations. Effects of inoculation time, mode of sampling, and sample storage time were assessed. The model was stable to 20 autoclaving cycles. There were no differences regarding the optimum coverage from the nose and from glass plates. Optimum sampling time was 1 h after inoculation. Storage time after sampling was of minor relevance for the recovery. Rotating the swab around its own axis while circling the nasal cavity resulted in best sampling results. The suitability of the assessed nose model for the comparison of sampling strategies and systems was confirmed. Without disadvantages in comparison with sampling from standardized glass plates, the model allows for the assessment of a correct sampling technique due to its anatomically correct shape.

  5. Generic vehicle speed models based on traffic simulation: Development and application

    Energy Technology Data Exchange (ETDEWEB)

    Margiotta, R.; Cohen, H.; Elkins, G.; Rathi, A.; Venigalla, M.

    1994-12-15

    This paper summarizes the findings of a research project to develop new methods of estimating speeds for inclusion in the Highway Performance Monitoring System (HPMS) Analytical Process. The paper focuses on the effects of traffic conditions excluding incidents (recurring congestion) on daily average ed and excess fuel consumption. A review of the literature revealed that many techniques have been used to predict speeds as a function of congestion but most fail to address the effects of queuing. However, the method of Dowling and Skabardonis avoids this limitation and was adapted to the research. The methodology used the FRESIM and NETSIM microscopic traffic simulation models to develop uncongested speed functions and as a calibration base for the congested flow functions. The chief contributions of the new speed models are the simplicity of application and their explicit accounting for the effects of queuing. Specific enhancements include: (1) the inclusion of a queue discharge rate for freeways; (2) use of newly defined uncongested flow speed functions; (3) use of generic temporal distributions that account for peak spreading; and (4) a final model form that allows incorporation of other factors that influence speed, such as grades and curves. The main limitation of the new speed models is the fact that they are based on simulation results and not on field observations. They also do not account for the effect of incidents on speed. While appropriate for estimating average national conditions, the use of fixed temporal distributions may not be suitable for analyzing specific facilities, depending on observed traffic patterns. Finally, it is recommended that these and all future speed models be validated against field data where incidents can be adequately identified in the data.

  6. Explorable Three-Dimensional Digital Model of the Female Pelvis, Pelvic Contents, and Perineum for Anatomical Education

    Science.gov (United States)

    Sergovich, Aimee; Johnson, Marjorie; Wilson, Timothy D.

    2010-01-01

    The anatomy of the pelvis is complex, multilayered, and its three-dimensional organization is conceptually difficult for students to grasp. The aim of this project was to create an explorable and projectable stereoscopic, three-dimensional (3D) model of the female pelvis and pelvic contents for anatomical education. The model was created using…

  7. Modeling HIV/AIDS drug price determinants in Brazil: is generic competition a myth?

    Science.gov (United States)

    Meiners, Constance; Sagaon-Teyssier, Luis; Hasenclever, Lia; Moatti, Jean-Paul

    2011-01-01

    Brazil became the first developing country to guarantee free and universal access to HIV/AIDS treatment, with antiretroviral drugs (ARVs) being delivered to nearly 190,000 patients. The analysis of ARV price evolution and market dynamics in Brazil can help anticipate issues soon to afflict other developing countries, as the 2010 revision of the World Health Organization guidelines shifts demand towards more expensive treatments, and, at the same time, current evolution of international legislation and trade agreements on intellectual property rights may reduce availability of generic drugs for HIV care. Our analyses are based on effective prices paid for ARV procurement in Brazil between 1996 and 2009. Data panel structure was exploited to gather ex-ante and ex-post information and address various sources of statistical bias. In-difference estimation offered in-depth information on ARV market characteristics which significantly influence prices. Although overall ARV prices follow a declining trend, changing characteristics in the generic segment help explain recent increase in generic ARV prices. Our results show that generic suppliers are more likely to respond to factors influencing demand size and market competition, while originator suppliers tend to set prices strategically to offset compulsory licensing threats and generic competition. In order to guarantee the long term sustainability of access to antiretroviral treatment, our findings highlight the importance of preserving and stimulating generic market dynamics to sustain developing countries' bargaining power in price negotiations undertaken with originator companies.

  8. Modeling HIV/AIDS drug price determinants in Brazil: is generic competition a myth?

    Directory of Open Access Journals (Sweden)

    Constance Meiners

    Full Text Available BACKGROUND: Brazil became the first developing country to guarantee free and universal access to HIV/AIDS treatment, with antiretroviral drugs (ARVs being delivered to nearly 190,000 patients. The analysis of ARV price evolution and market dynamics in Brazil can help anticipate issues soon to afflict other developing countries, as the 2010 revision of the World Health Organization guidelines shifts demand towards more expensive treatments, and, at the same time, current evolution of international legislation and trade agreements on intellectual property rights may reduce availability of generic drugs for HIV care. METHODS AND FINDINGS: Our analyses are based on effective prices paid for ARV procurement in Brazil between 1996 and 2009. Data panel structure was exploited to gather ex-ante and ex-post information and address various sources of statistical bias. In-difference estimation offered in-depth information on ARV market characteristics which significantly influence prices. Although overall ARV prices follow a declining trend, changing characteristics in the generic segment help explain recent increase in generic ARV prices. Our results show that generic suppliers are more likely to respond to factors influencing demand size and market competition, while originator suppliers tend to set prices strategically to offset compulsory licensing threats and generic competition. SIGNIFICANCE: In order to guarantee the long term sustainability of access to antiretroviral treatment, our findings highlight the importance of preserving and stimulating generic market dynamics to sustain developing countries' bargaining power in price negotiations undertaken with originator companies.

  9. Generic Screening Models for Assessing Exposures to the Public and ICRP Reference Animals and Plants

    Energy Technology Data Exchange (ETDEWEB)

    Yankovich, Tamara L.; Proehl, Gerhard; Telleria, Diego [International Atomic Energy Agency, P.O. Box 100, 1400 Vienna (Austria); Berkovskyy, Volodymyr [Ukrainian Radiation Protection Institute (RPI), 53, Melnikova Street, 04050, Kiev (Ukraine)

    2014-07-01

    With the update of the IAEA Fundamental Safety Principles (SF-1) stating the objective to protect people and the environment from harmful effects of ionizing radiation, it has been necessary to update International Basic Safety Standards (BSS) on Radiation Protection and Safety of Radiation Sources and the underlying safety guides and technical documents to provide guidance on how this could be achieved in practice. The current paper provides an update on the status and plans to revise the IAEA Safety Report 'Generic Models for Use in Assessing the Impact of Discharges of Radioactive Substances to the Environment' (SRS 19) that was published in 2001. The models of SRS 19 (2001), which was focused on assessment of exposures to the public, is being expanded into three volumes that provide methodologies for screening assessments for the public, as well as for flora and fauna. The revised SRS 19 guide will ultimately facilitate the application of screening models for different levels of assessment using updated parameter values from database that have been developed as part of the IAEA's EMRAS (Environmental Modelling for Radiation Safety) and EMRAS II international model validation programmes. The scope of the revised SRS 19 covers prospective screening assessment of doses to the representative person and Reference Animals and Plants (RAPs), and will provide simple and robust assessment methods for radiological assessment related to planning and design, applying a graded approach. Tabulated screening coefficients and environmental dilution factors will be included for 825 radionuclides. The screening coefficients are developed assuming equilibrium conditions; they can be used to assess radiological impacts arising from routine discharges of radionuclides to terrestrial and aquatic receptors for planned exposure situations. Volumes 1 and 2 of the revised SRS 19 are at an advanced stage of completion and are focused on 'Screening Assessment of Public

  10. Predicting cortical ROIs via joint modeling of anatomical and connectional profiles.

    Science.gov (United States)

    Zhang, Tuo; Zhu, Dajiang; Jiang, Xi; Ge, Bao; Hu, Xintao; Han, Junwei; Guo, Lei; Liu, Tianming

    2013-08-01

    Localization of cortical regions of interests (ROIs) in structural neuroimaging data such as diffusion tensor imaging (DTI) and T1-weighted MRI images has significant importance in basic and clinical neurosciences. However, this problem is considerably challenging due to the lack of quantitative mapping between brain structure and function, which relies on the availability of multimodal training data including benchmark task-based functional MRI (fMRI) images and effective machine learning algorithms. This paper presents a novel joint modeling approach that learns predictive models of ROIs from concurrent task-based fMRI, DTI, and T1-weighted MRI datasets. In particular, the effective generalized multiple kernel learning (GMKL) algorithm and ROI coordinate principal component analysis (PCA) model are employed to infer the intrinsic relationships between anatomical T1-weighted MRI/connectional DTI features and task-based fMRI-derived functional ROIs. Then, these predictive models of cortical ROIs are evaluated by cross-validation studies, independent datasets, and reproducibility studies. Experimental results are promising. We envision that these predictive models can be potentially applied in many scenarios that have only DTI and/or T1-weighted MRI data, but without task-based fMRI data. Copyright © 2013 Elsevier B.V. All rights reserved.

  11. Evaluation and calibration of functional network modeling methods based on known anatomical connections.

    Science.gov (United States)

    Dawson, Debra Ann; Cha, Kuwook; Lewis, Lindsay B; Mendola, Janine D; Shmuel, Amir

    2013-02-15

    Recent studies have identified large scale brain networks based on the spatio-temporal structure of spontaneous fluctuations in resting-state fMRI data. It is expected that functional connectivity based on resting-state data is reflective of - but not identical to - the underlying anatomical connectivity. However, which functional connectivity analysis methods reliably predict the network structure remains unclear. Here we tested and compared network connectivity analysis methods by applying them to fMRI resting-state time-series obtained from the human visual cortex. The methods evaluated here are those previously tested against simulated data in Smith et al. (Neuroimage, 2011). To this end, we defined regions within retinotopic visual areas V1, V2, and V3 according to their eccentricity in the visual field, delineating central, intermediate, and peripheral eccentricity regions of interest (ROIs). These ROIs served as nodes in the models we study. We based our evaluation on the "ground-truth", thoroughly studied retinotopically-organized anatomical connectivity in the monkey visual cortex. For each evaluated method, we computed the fractional rate of detecting connections known to exist ("c-sensitivity"), while using a threshold of the 95th percentile of the distribution of interaction magnitudes of those connections not expected to exist. Under optimal conditions - including session duration of 68min, a relatively small network consisting of 9 nodes and artifact-free regression of the global effect - each of the top methods predicted the expected connections with 67-85% c-sensitivity. Correlation methods, including Correlation (Corr; 85%), Regularized Inverse Covariance (ICOV; 84%) and Partial Correlation (PCorr; 81%) performed best, followed by Patel's Kappa (80%), Bayesian Network method PC (BayesNet; 77%), General Synchronization measures (67-77%), and Coherence (CohB; 74%). With decreased session duration, these top methods saw decreases in c

  12. Pancreatic Expression database: a generic model for the organization, integration and mining of complex cancer datasets

    Directory of Open Access Journals (Sweden)

    Lemoine Nicholas R

    2007-11-01

    of genes associated with the progression of cancer, cross-platform meta-analysis, SNP selection for pancreatic cancer association studies, cancer gene promoter analysis as well as mining cancer ontology information. The data model is generic and can be easily extended and applied to other types of cancer. The database is available online with no restrictions for the scientific community at http://www.pancreasexpression.org/.

  13. Thermal effect of microwave antenna radiation on a generic model of thyroid gland

    Science.gov (United States)

    Gavriloaia, Gheorghe; Gavriloaia, Mariuca-Roxana; Ghemigean, Adina-Mariana

    2010-11-01

    The rapid diffusion of wireless communication systems has caused an increased concern for the potential detrimental effects on human health deriving from exposure to electromagnetic field. It penetrates the body and acts on all the organs, altering the cell membrane potential and the distribution of ions and dipoles. The thyroid gland is one of the most exposed vital organs and may be a target for electromagnetic radiation. This paper presents the computed temperature and specific absorption rate inside to a generic model of a human thyroid using signals radiated by an antenna operating in the 2450 MHz band and the power density levels up to 100 W/cm2. Calculations were carried out using the Finite Difference Time Domain method for the solving of two coupled differential equations, Maxwell and Pennes. The results show that the temperature can rise up to very dangerous levels, i.e., 46 °C, in a very short time. The estimated temperature distribution in the human thyroid due to exposure from microwave signals can be used to design the dangerous aria for personal working around high power emitted antenna and for medical applications.

  14. Model of a Generic Natural Uranium Conversion Plant ? Suggested Measures to Strengthen International Safeguards

    Energy Technology Data Exchange (ETDEWEB)

    Raffo-Caiado, Ana Claudia [ORNL; Begovich, John M [ORNL; Ferrada, Juan J [ORNL

    2009-11-01

    This is the final report that closed a joint collaboration effort between DOE and the National Nuclear Energy Commission of Brazil (CNEN). In 2005, DOE and CNEN started a collaborative effort to evaluate measures that can strengthen the effectiveness of international safeguards at a natural uranium conversion plant (NUCP). The work was performed by DOE s Oak Ridge National Laboratory and CNEN. A generic model of a NUCP was developed and typical processing steps were defined. Advanced instrumentation and techniques for verification purposes were identified and investigated. The scope of the work was triggered by the International Atomic Energy Agency s 2003 revised policy concerning the starting point of safeguards at uranium conversion facilities. Prior to this policy only the final products of the uranium conversion plant were considered to be of composition and purity suitable for use in the nuclear fuel cycle and therefore, subject to the IAEA safeguards control. DOE and CNEN have explored options for implementing the IAEA policy, although Brazil understands that the new policy established by the IAEA is beyond the framework of the Quadripartite Agreement of which it is one of the parties, together with Argentina, the Brazilian-Argentine Agency for Accounting and Control of Nuclear Materials (ABACC) and the IAEA. Two technical papers on this subject were published at the 2005 and 2008 INMM Annual Meetings.

  15. Heuristic Optimization of Consumer Electricity Costs Using a Generic Cost Model

    Directory of Open Access Journals (Sweden)

    Chris Ogwumike

    2015-12-01

    Full Text Available Many new demand response strategies are emerging for energy management in smart grids. Real-Time Energy Pricing (RTP is one important aspect of consumer Demand Side Management (DSM, which encourages consumers to participate in load scheduling. This can help reduce peak demand and improve power system efficiency. The use of Intelligent Decision Support Systems (IDSSs for load scheduling has become necessary in order to enable consumers to respond to the changing economic value of energy across different hours of the day. The type of scheduling problem encountered by a consumer IDSS is typically NP-hard, which warrants the search for good heuristics with efficient computational performance and ease of implementation. This paper presents an extensive evaluation of a heuristic scheduling algorithm for use in a consumer IDSS. A generic cost model for hourly pricing is utilized, which can be configured for traditional on/off peak pricing, RTP, Time of Use Pricing (TOUP, Two-Tier Pricing (2TP and combinations thereof. The heuristic greedily schedules controllable appliances to minimize smart appliance energy costs and has a polynomial worst-case computation time. Extensive computational experiments demonstrate the effectiveness of the algorithm and the obtained results indicate the gaps between the optimal achievable costs are negligible.

  16. Qualitative analysis of Kantowski-Sachs metric in a generic class of f(R) models

    Energy Technology Data Exchange (ETDEWEB)

    Leon, Genly [Instituto de Física, Pontificia Universidad Católica de Valparaíso, Casilla 4950, Valparaíso (Chile); Roque, Armando A., E-mail: genly.leon@ucv.cl, E-mail: arestrada@ucf.edu.cu [Grupo de Estudios Avanzados, Universidad de Cienfuegos, Carretera a Rodas, Cuatro Caminos, s/n. Cienfuegos (Cuba)

    2014-05-01

    In this paper we investigate, from the dynamical systems perspective, the evolution of a Kantowski-Sachs metric in a generic class of f(R) models. We present conditions (i.e., differentiability conditions, existence of minima, monotony intervals, etc.) for a free input function related to the f(R), that guarantee the asymptotic stability of well-motivated physical solutions, specially, self-accelerated solutions, allowing to describe both inflationary- and late-time acceleration stages of the cosmic evolution. We discuss which f(R) theories allows for a cosmic evolution with an acceptable matter era, in correspondence to the modern cosmological paradigm. We find a very rich behavior, and amongst others the universe can result in isotropized solutions with observables in agreement with observations, such as de Sitter, quintessence-like, or phantom solutions. Additionally, we find that a cosmological bounce and turnaround are realized in a part of the parameter-space as a consequence of the metric choice.

  17. Qualitative analysis of Kantowski-Sachs metric in a generic class of $f(R)$ models

    CERN Document Server

    Leon, Genly

    2013-01-01

    In this paper we investigate, from the dynamical systems perspective, the evolution of a Kantowski-Sachs metric in a generic class of $f(R)$ models. We present conditions (i. e., differentiability conditions, existence of minima, monotony intervals, etc.) for a free input function related to the $f(R)$, that guarantee the asymptotic stability of well-motivated physical solutions, specially, self-accelerated solutions, allowing to describe both inflationary- and late-time acceleration stages of the cosmic evolution. We discuss which $f(R)$ theories allows for a cosmic evolution with an acceptable matter era, in correspondence to the modern cosmological paradigm. We find a very rich behavior, and amongst others the universe can result in isotropized solutions with observables in agreement with observations, such as de Sitter, quintessence-like, or phantom solutions. Additionally, we find that a cosmological bounce and turnaround are realized in a part of the parameter-space as a consequence of the metric choice...

  18. Model of a Generic Natural Uranium Conversion Plant ? Suggested Measures to Strengthen International Safeguards

    Energy Technology Data Exchange (ETDEWEB)

    Raffo-Caiado, Ana Claudia [ORNL; Begovich, John M [ORNL; Ferrada, Juan J [ORNL

    2009-11-01

    This is the final report that closed a joint collaboration effort between DOE and the National Nuclear Energy Commission of Brazil (CNEN). In 2005, DOE and CNEN started a collaborative effort to evaluate measures that can strengthen the effectiveness of international safeguards at a natural uranium conversion plant (NUCP). The work was performed by DOE s Oak Ridge National Laboratory and CNEN. A generic model of a NUCP was developed and typical processing steps were defined. Advanced instrumentation and techniques for verification purposes were identified and investigated. The scope of the work was triggered by the International Atomic Energy Agency s 2003 revised policy concerning the starting point of safeguards at uranium conversion facilities. Prior to this policy only the final products of the uranium conversion plant were considered to be of composition and purity suitable for use in the nuclear fuel cycle and therefore, subject to the IAEA safeguards control. DOE and CNEN have explored options for implementing the IAEA policy, although Brazil understands that the new policy established by the IAEA is beyond the framework of the Quadripartite Agreement of which it is one of the parties, together with Argentina, the Brazilian-Argentine Agency for Accounting and Control of Nuclear Materials (ABACC) and the IAEA. Two technical papers on this subject were published at the 2005 and 2008 INMM Annual Meetings.

  19. Short Term Evaluation of an Anatomically Shaped Polycarbonate Urethane Total Meniscus Replacement in a Goat Model.

    Directory of Open Access Journals (Sweden)

    A C T Vrancken

    Full Text Available Since the treatment options for symptomatic total meniscectomy patients are still limited, an anatomically shaped, polycarbonate urethane (PCU, total meniscus replacement was developed. This study evaluates the in vivo performance of the implant in a goat model, with a specific focus on the implant location in the joint, geometrical integrity of the implant and the effect of the implant on synovial membrane and articular cartilage histopathological condition.The right medial meniscus of seven Saanen goats was replaced by the implant. Sham surgery (transection of the MCL, arthrotomy and MCL suturing was performed in six animals. The contralateral knee joints of both groups served as control groups. After three months follow-up the following aspects of implant performance were evaluated: implant position, implant deformation and the histopathological condition of the synovium and cartilage.Implant geometry was well maintained during the three month implantation period. No signs of PCU wear were found and the implant did not induce an inflammatory response in the knee joint. In all animals, implant fixation was compromised due to suture breakage, wear or elongation, likely causing the increase in extrusion observed in the implant group. Both the femoral cartilage and tibial cartilage in direct contact with the implant showed increased damage compared to the sham and sham-control groups.This study demonstrates that the novel, anatomically shaped PCU total meniscal replacement is biocompatible and resistant to three months of physiological loading. Failure of the fixation sutures may have increased implant mobility, which probably induced implant extrusion and potentially stimulated cartilage degeneration. Evidently, redesigning the fixation method is necessary. Future animal studies should evaluate the improved fixation method and compare implant performance to current treatment standards, such as allografts.

  20. Airways, vasculature, and interstitial tissue: anatomically informed computational modeling of human lungs for virtual clinical trials

    Science.gov (United States)

    Abadi, Ehsan; Sturgeon, Gregory M.; Agasthya, Greeshma; Harrawood, Brian; Hoeschen, Christoph; Kapadia, Anuj; Segars, W. P.; Samei, Ehsan

    2017-03-01

    This study aimed to model virtual human lung phantoms including both non-parenchymal and parenchymal structures. Initial branches of the non-parenchymal structures (airways, arteries, and veins) were segmented from anatomical data in each lobe separately. A volume-filling branching algorithm was utilized to grow the higher generations of the airways and vessels to the level of terminal branches. The diameters of the airways and vessels were estimated using established relationships between flow rates and diameters. The parenchyma was modeled based on secondary pulmonary lobule units. Polyhedral shapes with variable sizes were modeled, and the borders were assigned to interlobular septa. A heterogeneous background was added inside these units using a non-parametric texture synthesis algorithm which was informed by a high-resolution CT lung specimen dataset. A voxelized based CT simulator was developed to create synthetic helical CT images of the phantom with different pitch values. Results showed the progressive degradation in depiction of lung details with increased pitch. Overall, the enhanced lung models combined with the XCAT phantoms prove to provide a powerful toolset to perform virtual clinical trials in the context of thoracic imaging. Such trials, not practical using clinical datasets or simplistic phantoms, can quantitatively evaluate and optimize advanced imaging techniques towards patient-based care.

  1. DYNAMO-HIA--a Dynamic Modeling tool for generic Health Impact Assessments.

    Directory of Open Access Journals (Sweden)

    Stefan K Lhachimi

    Full Text Available BACKGROUND: Currently, no standard tool is publicly available that allows researchers or policy-makers to quantify the impact of policies using epidemiological evidence within the causal framework of Health Impact Assessment (HIA. A standard tool should comply with three technical criteria (real-life population, dynamic projection, explicit risk-factor states and three usability criteria (modest data requirements, rich model output, generally accessible to be useful in the applied setting of HIA. With DYNAMO-HIA (Dynamic Modeling for Health Impact Assessment, we introduce such a generic software tool specifically designed to facilitate quantification in the assessment of the health impacts of policies. METHODS AND RESULTS: DYNAMO-HIA quantifies the impact of user-specified risk-factor changes on multiple diseases and in turn on overall population health, comparing one reference scenario with one or more intervention scenarios. The Markov-based modeling approach allows for explicit risk-factor states and simulation of a real-life population. A built-in parameter estimation module ensures that only standard population-level epidemiological evidence is required, i.e. data on incidence, prevalence, relative risks, and mortality. DYNAMO-HIA provides a rich output of summary measures--e.g. life expectancy and disease-free life expectancy--and detailed data--e.g. prevalences and mortality/survival rates--by age, sex, and risk-factor status over time. DYNAMO-HIA is controlled via a graphical user interface and is publicly available from the internet, ensuring general accessibility. We illustrate the use of DYNAMO-HIA with two example applications: a policy causing an overall increase in alcohol consumption and quantifying the disease-burden of smoking. CONCLUSION: By combining modest data needs with general accessibility and user friendliness within the causal framework of HIA, DYNAMO-HIA is a potential standard tool for health impact assessment based

  2. MIDA: A Multimodal Imaging-Based Detailed Anatomical Model of the Human Head and Neck.

    Directory of Open Access Journals (Sweden)

    Maria Ida Iacono

    Full Text Available Computational modeling and simulations are increasingly being used to complement experimental testing for analysis of safety and efficacy of medical devices. Multiple voxel- and surface-based whole- and partial-body models have been proposed in the literature, typically with spatial resolution in the range of 1-2 mm and with 10-50 different tissue types resolved. We have developed a multimodal imaging-based detailed anatomical model of the human head and neck, named "MIDA". The model was obtained by integrating three different magnetic resonance imaging (MRI modalities, the parameters of which were tailored to enhance the signals of specific tissues: i structural T1- and T2-weighted MRIs; a specific heavily T2-weighted MRI slab with high nerve contrast optimized to enhance the structures of the ear and eye; ii magnetic resonance angiography (MRA data to image the vasculature, and iii diffusion tensor imaging (DTI to obtain information on anisotropy and fiber orientation. The unique multimodal high-resolution approach allowed resolving 153 structures, including several distinct muscles, bones and skull layers, arteries and veins, nerves, as well as salivary glands. The model offers also a detailed characterization of eyes, ears, and deep brain structures. A special automatic atlas-based segmentation procedure was adopted to include a detailed map of the nuclei of the thalamus and midbrain into the head model. The suitability of the model to simulations involving different numerical methods, discretization approaches, as well as DTI-based tensorial electrical conductivity, was examined in a case-study, in which the electric field was generated by transcranial alternating current stimulation. The voxel- and the surface-based versions of the models are freely available to the scientific community.

  3. MIDA: A Multimodal Imaging-Based Detailed Anatomical Model of the Human Head and Neck.

    Science.gov (United States)

    Iacono, Maria Ida; Neufeld, Esra; Akinnagbe, Esther; Bower, Kelsey; Wolf, Johanna; Vogiatzis Oikonomidis, Ioannis; Sharma, Deepika; Lloyd, Bryn; Wilm, Bertram J; Wyss, Michael; Pruessmann, Klaas P; Jakab, Andras; Makris, Nikos; Cohen, Ethan D; Kuster, Niels; Kainz, Wolfgang; Angelone, Leonardo M

    2015-01-01

    Computational modeling and simulations are increasingly being used to complement experimental testing for analysis of safety and efficacy of medical devices. Multiple voxel- and surface-based whole- and partial-body models have been proposed in the literature, typically with spatial resolution in the range of 1-2 mm and with 10-50 different tissue types resolved. We have developed a multimodal imaging-based detailed anatomical model of the human head and neck, named "MIDA". The model was obtained by integrating three different magnetic resonance imaging (MRI) modalities, the parameters of which were tailored to enhance the signals of specific tissues: i) structural T1- and T2-weighted MRIs; a specific heavily T2-weighted MRI slab with high nerve contrast optimized to enhance the structures of the ear and eye; ii) magnetic resonance angiography (MRA) data to image the vasculature, and iii) diffusion tensor imaging (DTI) to obtain information on anisotropy and fiber orientation. The unique multimodal high-resolution approach allowed resolving 153 structures, including several distinct muscles, bones and skull layers, arteries and veins, nerves, as well as salivary glands. The model offers also a detailed characterization of eyes, ears, and deep brain structures. A special automatic atlas-based segmentation procedure was adopted to include a detailed map of the nuclei of the thalamus and midbrain into the head model. The suitability of the model to simulations involving different numerical methods, discretization approaches, as well as DTI-based tensorial electrical conductivity, was examined in a case-study, in which the electric field was generated by transcranial alternating current stimulation. The voxel- and the surface-based versions of the models are freely available to the scientific community.

  4. Principal component analysis-based anatomical motion models for use in adaptive radiation therapy of head and neck cancer patients

    Science.gov (United States)

    Chetvertkov, Mikhail A.

    Purpose: To develop standard and regularized principal component analysis (PCA) models of anatomical changes from daily cone beam CTs (CBCTs) of head and neck (H&N) patients, assess their potential use in adaptive radiation therapy (ART), and to extract quantitative information for treatment response assessment. Methods: Planning CT (pCT) images of H&N patients were artificially deformed to create "digital phantom" images, which modeled systematic anatomical changes during Radiation Therapy (RT). Artificial deformations closely mirrored patients' actual deformations, and were interpolated to generate 35 synthetic CBCTs, representing evolving anatomy over 35 fractions. Deformation vector fields (DVFs) were acquired between pCT and synthetic CBCTs (i.e., digital phantoms), and between pCT and clinical CBCTs. Patient-specific standard PCA (SPCA) and regularized PCA (RPCA) models were built from these synthetic and clinical DVF sets. Eigenvectors, or eigenDVFs (EDVFs), having the largest eigenvalues were hypothesized to capture the major anatomical deformations during treatment. Modeled anatomies were used to assess the dose deviations with respect to the planned dose distribution. Results: PCA models achieve variable results, depending on the size and location of anatomical change. Random changes prevent or degrade SPCA's ability to detect underlying systematic change. RPCA is able to detect smaller systematic changes against the background of random fraction-to-fraction changes, and is therefore more successful than SPCA at capturing systematic changes early in treatment. SPCA models were less successful at modeling systematic changes in clinical patient images, which contain a wider range of random motion than synthetic CBCTs, while the regularized approach was able to extract major modes of motion. For dose assessment it has been shown that the modeled dose distribution was different from the planned dose for the parotid glands due to their shrinkage and shift into

  5. Action potential generation in an anatomically constrained model of medial superior olive axons.

    Science.gov (United States)

    Lehnert, Simon; Ford, Marc C; Alexandrova, Olga; Hellmundt, Franziska; Felmy, Felix; Grothe, Benedikt; Leibold, Christian

    2014-04-09

    Neurons in the medial superior olive (MSO) encode interaural time differences (ITDs) with sustained firing rates of >100 Hz. They are able to generate such high firing rates for several hundred milliseconds despite their extremely low-input resistances of only few megaohms and high synaptic conductances in vivo. The biophysical mechanisms by which these leaky neurons maintain their excitability are not understood. Since action potentials (APs) are usually assumed to be generated in the axon initial segment (AIS), we analyzed anatomical data of proximal MSO axons in Mongolian gerbils and found that the axon diameter is <1 μm and the internode length is ∼100 μm. Using a morphologically constrained computational model of the MSO axon, we show that these thin axons facilitate the excitability of the AIS. However, for ongoing high rates of synaptic inputs the model generates a substantial fraction of APs in its nodes of Ranvier. These distally initiated APs are mediated by a spatial gradient of sodium channel inactivation and a strong somatic current sink. The model also predicts that distal AP initiation increases the dynamic range of the rate code for ITDs.

  6. Dual-Extrusion 3D Printing of Anatomical Models for Education.

    Science.gov (United States)

    Smith, Michelle L; Jones, James F X

    2017-09-14

    Two material 3D printing is becoming increasingly popular, inexpensive and accessible. In this paper, freely available printable files and dual extrusion fused deposition modelling were combined to create a number of functional anatomical models. To represent muscle and bone FilaFlex(3D) flexible filament and polylactic acid (PLA) filament were extruded respectively via a single 0.4 mm nozzle using a Big Builder printer. For each filament, cubes (5 mm(3) ) were printed and analyzed for X, Y, and Z accuracy. The PLA printed cubes resulted in errors averaging just 1.2% across all directions but for FilaFlex(3D) printed cubes the errors were statistically significantly greater (average of 3.2%). As an exemplar, a focus was placed on the muscles, bones and cartilage of upper airway and neck. The resulting single prints combined flexible and hard structures. A single print model of the vocal cords was constructed which permitted movement of the arytenoids on the cricoid cartilage and served to illustrate the action of intrinsic laryngeal muscles. As University libraries become increasingly engaged in offering inexpensive 3D printing services it may soon become common place for both student and educator to access websites, download free models or 3D body parts and only pay the costs of print consumables. Novel models can be manufactured as dissectible, functional multi-layered units and offer rich possibilities for sectional and/or reduced anatomy. This approach can liberate the anatomist from constraints of inflexible hard models or plastinated specimens and engage in the design of class specific models of the future. Anat Sci Educ. © 2017 American Association of Anatomists. © 2017 American Association of Anatomists.

  7. ECO: a generic eutrophication model including comprehensive sediment-water interaction.

    Directory of Open Access Journals (Sweden)

    Johannes G C Smits

    Full Text Available The content and calibration of the comprehensive generic 3D eutrophication model ECO for water and sediment quality is presented. Based on a computational grid for water and sediment, ECO is used as a tool for water quality management to simulate concentrations and mass fluxes of nutrients (N, P, Si, phytoplankton species, detrital organic matter, electron acceptors and related substances. ECO combines integral simulation of water and sediment quality with sediment diagenesis and closed mass balances. Its advanced process formulations for substances in the water column and the bed sediment were developed to allow for a much more dynamic calculation of the sediment-water exchange fluxes of nutrients as resulting from steep concentration gradients across the sediment-water interface than is possible with other eutrophication models. ECO is to more accurately calculate the accumulation of organic matter and nutrients in the sediment, and to allow for more accurate prediction of phytoplankton biomass and water quality in response to mitigative measures such as nutrient load reduction. ECO was calibrated for shallow Lake Veluwe (The Netherlands. Due to restoration measures this lake underwent a transition from hypertrophic conditions to moderately eutrophic conditions, leading to the extensive colonization by submerged macrophytes. ECO reproduces observed water quality well for the transition period of ten years. The values of its process coefficients are in line with ranges derived from literature. ECO's calculation results underline the importance of redox processes and phosphate speciation for the nutrient return fluxes. Among other things, the results suggest that authigenic formation of a stable apatite-like mineral in the sediment can contribute significantly to oligotrophication of a lake after a phosphorus load reduction.

  8. ECO: a generic eutrophication model including comprehensive sediment-water interaction.

    Science.gov (United States)

    Smits, Johannes G C; van Beek, Jan K L

    2013-01-01

    The content and calibration of the comprehensive generic 3D eutrophication model ECO for water and sediment quality is presented. Based on a computational grid for water and sediment, ECO is used as a tool for water quality management to simulate concentrations and mass fluxes of nutrients (N, P, Si), phytoplankton species, detrital organic matter, electron acceptors and related substances. ECO combines integral simulation of water and sediment quality with sediment diagenesis and closed mass balances. Its advanced process formulations for substances in the water column and the bed sediment were developed to allow for a much more dynamic calculation of the sediment-water exchange fluxes of nutrients as resulting from steep concentration gradients across the sediment-water interface than is possible with other eutrophication models. ECO is to more accurately calculate the accumulation of organic matter and nutrients in the sediment, and to allow for more accurate prediction of phytoplankton biomass and water quality in response to mitigative measures such as nutrient load reduction. ECO was calibrated for shallow Lake Veluwe (The Netherlands). Due to restoration measures this lake underwent a transition from hypertrophic conditions to moderately eutrophic conditions, leading to the extensive colonization by submerged macrophytes. ECO reproduces observed water quality well for the transition period of ten years. The values of its process coefficients are in line with ranges derived from literature. ECO's calculation results underline the importance of redox processes and phosphate speciation for the nutrient return fluxes. Among other things, the results suggest that authigenic formation of a stable apatite-like mineral in the sediment can contribute significantly to oligotrophication of a lake after a phosphorus load reduction.

  9. PIV-measured versus CFD-predicted flow dynamics in anatomically realistic cerebral aneurysm models.

    Science.gov (United States)

    Ford, Matthew D; Nikolov, Hristo N; Milner, Jaques S; Lownie, Stephen P; Demont, Edwin M; Kalata, Wojciech; Loth, Francis; Holdsworth, David W; Steinman, David A

    2008-04-01

    Computational fluid dynamics (CFD) modeling of nominally patient-specific cerebral aneurysms is increasingly being used as a research tool to further understand the development, prognosis, and treatment of brain aneurysms. We have previously developed virtual angiography to indirectly validate CFD-predicted gross flow dynamics against the routinely acquired digital subtraction angiograms. Toward a more direct validation, here we compare detailed, CFD-predicted velocity fields against those measured using particle imaging velocimetry (PIV). Two anatomically realistic flow-through phantoms, one a giant internal carotid artery (ICA) aneurysm and the other a basilar artery (BA) tip aneurysm, were constructed of a clear silicone elastomer. The phantoms were placed within a computer-controlled flow loop, programed with representative flow rate waveforms. PIV images were collected on several anterior-posterior (AP) and lateral (LAT) planes. CFD simulations were then carried out using a well-validated, in-house solver, based on micro-CT reconstructions of the geometries of the flow-through phantoms and inlet/outlet boundary conditions derived from flow rates measured during the PIV experiments. PIV and CFD results from the central AP plane of the ICA aneurysm showed a large stable vortex throughout the cardiac cycle. Complex vortex dynamics, captured by PIV and CFD, persisted throughout the cardiac cycle on the central LAT plane. Velocity vector fields showed good overall agreement. For the BA, aneurysm agreement was more compelling, with both PIV and CFD similarly resolving the dynamics of counter-rotating vortices on both AP and LAT planes. Despite the imposition of periodic flow boundary conditions for the CFD simulations, cycle-to-cycle fluctuations were evident in the BA aneurysm simulations, which agreed well, in terms of both amplitudes and spatial distributions, with cycle-to-cycle fluctuations measured by PIV in the same geometry. The overall good agreement

  10. Model observer design for multi-signal detection in the presence of anatomical noise

    Science.gov (United States)

    Wen, Gezheng; Markey, Mia K.; Park, Subok

    2017-02-01

    As psychophysical studies are resource-intensive to conduct, model observers are commonly used to assess and optimize medical imaging quality. Model observers are typically designed to detect at most one signal. However, in clinical practice, there may be multiple abnormalities in a single image set (e.g. multifocal multicentric (MFMC) breast cancer), which can impact treatment planning. Prevalence of signals can be different across anatomical regions, and human observers do not know the number or location of signals a priori. As new imaging techniques have the potential to improve multiple-signal detection (e.g. digital breast tomosynthesis may be more effective for diagnosis of MFMC than mammography), image quality assessment approaches addressing such tasks are needed. In this study, we present a model observer to detect multiple signals in an image dataset. A novel implementation of partial least squares (PLS) was developed to estimate different sets of efficient channels directly from the images. The PLS channels are adaptive to the characteristics of signals and the background, and they capture the interactions among signal locations. Corresponding linear decision templates are employed to generate both image-level and location-specific scores on the presence of signals. Our results show that: (1) the model observer can achieve high performance with a reasonably small number of channels; (2) the model observer with PLS channels outperforms that with benchmark modified Laguerre–Gauss channels, especially when realistic signal shapes and complex background statistics are involved; (3) the tasks of clinical interest, and other constraints such as sample size would alter the optimal design of the model observer.

  11. Control of Process Operations and Monitoring of Product Qualities through Generic Model-based Framework in Crystallization Processes

    DEFF Research Database (Denmark)

    Abdul Samad, Noor Asma Fazli Bin

    A generic and systematic model-based framework for the design of a process monitoring and control system to achieve the desired crystal size distribution (CSD) and crystal shape for a wide range of crystallization processes has been developed. This framework combines a generic multi......-dimensional to a twodimensional description; b) the systematic framework is used in a case study to design a monitoring and control (PAT) system for a potassium dichromate and KDP crystallization processes to achieve the desired target CSD respectively; and c) Based on the PAT system design in b), the application of uncertainty......-dimensional modelling framework, tools for design of set point profiles, for design of PAT (Process Analytical Technology) systems as well as option to perform the uncertainty and sensitivity analysis of the PAT system design. Through this framework, it is possible for a wide range of crystallization processes...

  12. How will climate change affect the vegetation cycle over France? A generic modeling approach

    Directory of Open Access Journals (Sweden)

    Nabil Laanaia

    2016-01-01

    Full Text Available The implementation of adaptation strategies of agriculture and forestry to climate change is conditioned by the knowledge of the impacts of climate change on the vegetation cycle and of the associated uncertainties. Using the same generic Land Surface Model (LSM to simulate the response of various vegetation types is more straightforward than using several specialized crop and forestry models, as model implementation differences are difficult to assess. The objective of this study is to investigate the potential of a LSM to address this issue. Using the SURFEX (“Surface Externalisée” modeling platform, we produced and analyzed 150-yr (1950–2100 simulations of the biomass of four vegetation types (rainfed straw cereals, rainfed grasslands, broadleaf and needleleaf forests and of the soil water content associated to each of these vegetation types over France. Statistical methods were used to quantify the impact of climate change on simulated phenological dates. The duration of soil moisture stress periods increases everywhere in France, especially for grasslands with, on average, an increase of 9 days per year in near-future (NF conditions and 36 days per year in distant-future (DF conditions. For all the vegetation types, leaf onset and the annual maximum LAI occur earlier. For straw cereals in the Languedoc-Provence-Corsica area, NF leaf onset occurs 18 days earlier and 37 days earlier in DF conditions, on average. On the other hand, local discrepancies are simulated for the senescence period (e.g. earlier in western and southern France for broadleaf forests, slightly later in mountainous areas of eastern France for both NF and DF. Changes in phenological dates are more uncertain in DF than in NF conditions in relation to differences in climate models, especially for forests. Finally, it is shown that while changes in leaf onset are mainly driven by air temperature, longer soil moisture stress periods trigger earlier leaf senescence

  13. Generic Models of Wind Turbine Generators for Advanced Applications in a VSC-based Offshore HVDC Network

    DEFF Research Database (Denmark)

    Zeni, Lorenzo; Margaris, Ioannis; Hansen, Anca Daniela;

    This paper focuses on generic Type 4 wind turbine generators models, their applicability in modern HVDC connections and their capability to provide advanced ancillary services therefrom. A point-to-point HVDC offshore connection is considered. Issues concerning coordinated HVDC and wind farm...... involving the HVDC converters- The performance against frequency disturbances of the two presented configurations is assessed and discussed by means of simulations....

  14. Model observer design for detecting multiple abnormalities in anatomical background images

    Science.gov (United States)

    Wen, Gezheng; Markey, Mia K.; Park, Subok

    2016-03-01

    As psychophysical studies are resource-intensive to conduct, model observers are commonly used to assess and optimize medical imaging quality. Existing model observers were typically designed to detect at most one signal. However, in clinical practice, there may be multiple abnormalities in a single image set (e.g., multifocal and multicentric breast cancers (MMBC)), which can impact treatment planning. Prevalence of signals can be different across anatomical regions, and human observers do not know the number or location of signals a priori. As new imaging techniques have the potential to improve multiple-signal detection (e.g., digital breast tomosynthesis may be more effective for diagnosis of MMBC than planar mammography), image quality assessment approaches addressing such tasks are needed. In this study, we present a model-observer mechanism to detect multiple signals in the same image dataset. To handle the high dimensionality of images, a novel implementation of partial least squares (PLS) was developed to estimate different sets of efficient channels directly from the images. Without any prior knowledge of the background or the signals, the PLS channels capture interactions between signals and the background which provide discriminant image information. Corresponding linear decision templates are employed to generate both image-level and location-specific scores on the presence of signals. Our preliminary results show that the model observer using PLS channels, compared to our first attempts with Laguerre-Gauss channels, can achieve high performance with a reasonably small number of channels, and the optimal design of the model observer may vary as the tasks of clinical interest change.

  15. A generic model of pattern formation in Mississippi Valley-Type deposits based on analytical findings

    Science.gov (United States)

    Kelka, Ulrich; Veveakis, Manolis; Beaudoin, Nicolas; Poulet, Thomas; Koehn, Daniel; Regenauer-Lieb, Klaus; Chung, Peter; Berndt, Jasper

    2016-04-01

    Rhythmically banded dolomites (zebra dolomite) are found worldwide, and are frequently associated with mineralization of the Mississippi Valley-Type (MVT). These rocks consist of dark fine grained and impurity-rich layers alternating with light coarse grained and virtually impurity-free layers. The texture of the light layers is similar to the one of tectonic syntaxial veins where crystals grow towards a median line. We present petrographic and chemical analysis of zebra dolomite samples from the San Vicente mine, Central Peru. The applied methods are petrographic microscopy, SEM, EBSD, EMP and LA-ICP-MS. The findings influence the development of a generic model of pattern formation. We found the density and the distribution of second-phase material to be one striking feature. The impurities are accumulated in the dark layers, which show an even higher density of second-phase material than the surrounding impurity-rich dolomite. With CL, it was possible to detect a luminescent structure in the center of the light bands which seems to be present independent of the thickness and spacing of the respective layers. This structure was analysed in more detail with EMP. We further found that the dolomite crystals in the dark and light layers are chemically similar but show a variation in some trace elements. Based on the analytical findings, we put forward a mathematical model of zebra dolomite formation based on Cnoidal waves. We believe that the light coarse grained layers represent hydromechanical instabilities arising during the diagenetic compaction of a fluid saturated, impurity-rich dolomite. Our approach is based on the extension of the classical compaction bands theory to a viscose, non-linear rheology. In the model, the spacing between two light coarse grained layers is linked to the compaction length during the pattern formation. With the formulation of a 1D steady-state solution we can relate the genesis of the structure to physical parameter, such as

  16. Generating 3D anatomically detailed models of the retina from OCT data sets: implications for computational modelling

    Science.gov (United States)

    Shalbaf, Farzaneh; Dokos, Socrates; Lovell, Nigel H.; Turuwhenua, Jason; Vaghefi, Ehsan

    2015-12-01

    Retinal prosthesis has been proposed to restore vision for those suffering from the retinal pathologies that mainly affect the photoreceptors layer but keep the inner retina intact. Prior to costly risky experimental studies computational modelling of the retina will help to optimize the device parameters and enhance the outcomes. Here, we developed an anatomically detailed computational model of the retina based on OCT data sets. The consecutive OCT images of individual were subsequently segmented to provide a 3D representation of retina in the form of finite elements. Thereafter, the electrical properties of the retina were modelled by implementing partial differential equation on the 3D mesh. Different electrode configurations, that is bipolar and hexapolar configurations, were implemented and the results were compared with the previous computational and experimental studies. Furthermore, the possible effects of the curvature of retinal layers on the current steering through the retina were proposed and linked to the clinical observations.

  17. Family Genericity

    DEFF Research Database (Denmark)

    Ernst, Erik

    2006-01-01

    Type abstraction in object-oriented languages embody two techniques, each with its own strenghts and weaknesses. The first technique is extension, yielding abstraction mechanisms with good support for gradual specification. The prime example is inheritance. The second technique is functional abst...... the result as family genericity. The presented language design has been implemented....

  18. Family Genericity

    DEFF Research Database (Denmark)

    Ernst, Erik

    2006-01-01

    Type abstraction in object-oriented languages embody two techniques, each with its own strenghts and weaknesses. The first technique is extension, yielding abstraction mechanisms with good support for gradual specification. The prime example is inheritance. The second technique is functional abst...... the result as family genericity. The presented language design has been implemented....

  19. Currents induced in anatomic models of the human for uniform and nonuniform power frequency magnetic fields.

    Science.gov (United States)

    Gandhi, O P; Kang, G; Wu, D; Lazzi, G

    2001-02-01

    We have used the quasi-static impedance method to calculate the currents induced in the nominal 2 x 2 x 3 and 6 mm resolution anatomically based models of the human body for exposure to magnetic fields at 60 Hz. Uniform magnetic fields of various orientations and magnitudes 1 or 0.417 mT suggested in the ACGIH and ICNIRP safety guidelines are used to calculate induced electric fields or current densities for the various glands and organs of the body including the pineal gland. The maximum 1 cm(2) area-averaged induced current densities for the central nervous system tissues, such as the brain and the spinal cord, were within the reference level of 10 mA/m(2) as suggested in the ICNIRP guidelines for magnetic fields (0.417 mT at 60 Hz). Tissue conductivities were found to play an important role and higher assumed tissue conductivities gave higher induced current densities. We have also determined the induced current density distributions for nonuniform magnetic fields associated with two commonly used electrical appliances, namely a hair dryer and a hair clipper. Because of considerably higher magnetic fields for the latter device, higher induced electric fields and current densities were calculated.

  20. SAR exposure from UHF RFID reader in adult, child, pregnant woman, and fetus anatomical models.

    Science.gov (United States)

    Fiocchi, Serena; Markakis, Ioannis A; Ravazzani, Paolo; Samaras, Theodoros

    2013-09-01

    The spread of radio frequency identification (RFID) devices in ubiquitous applications without their simultaneous exposure assessment could give rise to public concerns about their potential adverse health effects. Among the various RFID system categories, the ultra high frequency (UHF) RFID systems have recently started to be widely used in many applications. This study addresses a computational exposure assessment of the electromagnetic radiation generated by a realistic UHF RFID reader, quantifying the exposure levels in different exposure scenarios and subjects (two adults, four children, and two anatomical models of women 7 and 9 months pregnant). The results of the computations are presented in terms of the whole-body and peak spatial specific absorption rate (SAR) averaged over 10 g of tissue to allow comparison with the basic restrictions of the exposure guidelines. The SAR levels in the adults and children were below 0.02 and 0.8 W/kg in whole-body SAR and maximum peak SAR levels, respectively, for all tested positions of the antenna. On the contrary, exposure of pregnant women and fetuses resulted in maximum peak SAR(10 g) values close to the values suggested by the guidelines (2 W/kg) in some of the exposure scenarios with the antenna positioned in front of the abdomen and with a 100% duty cycle and 1 W radiated power.

  1. Intraosseous rotation of the scaphoid: assessment by using a 3D CT model - an anatomic study

    Energy Technology Data Exchange (ETDEWEB)

    Schmidle, Gernot; Gabl, Markus [Medical University Innsbruck, Department of Trauma Surgery, Innsbruck (Austria); Rieger, Michael [Regional Hospital Hall, Department of Radiology, Hall in Tirol (Austria); Klauser, Andrea Sabine; Thauerer, Michael [Medical University Innsbruck, Department of Radiology, Innsbruck (Austria); Hoermann, Romed [Medical University Innsbruck, Department of Anatomy, Histology and Embryology-Division of Clinical and Functional Anatomy, Innsbruck (Austria)

    2014-06-15

    The purpose of this study was to assess intraosseous rotation as the third dimension of scaphoid anatomy on a 3D CT model using common volume rendering software to impact anatomical reconstruction of scaphoid fractures. CT images of 13 cadaver wrist pairs were acquired. Reference axes for the alignment of distal and proximal scaphoid poles were defined three-dimensionally. Two methods for rotation measurement - the reference axis method (RAM) and the scapho-trapezio-trapezoidal joint method (STTM) - were developed and compared by three independent observers. Rotation measured by the RAM averaged 66.9 ± 7 for the right and 67.2 ± 5.8 for the left wrists. Using the STTM there was a mean rotation of 68.6 ± 6.6 for the right and 68.6 ± 6.8 for the left wrists. The overall results showed a significant variability of the measured values between different specimens (P < 0.05). There was no significant difference between left and right wrists of the same specimen, neither for the RAM (P = 0.268) nor for the STTM (P = 0.774). Repeatability coefficients between the observers were low, indicating good repeatability. The presented methods are practical tools to quantify intraosseous rotation between distal and proximal scaphoid poles using common volume rendering software. For clinical application the opposite side provides the best reference values to assess malrotation in scaphoid fracture cases. (orig.)

  2. A Generic Approach to Self-localization and Mapping of Mobile Robots Without Using a Kinematic Model

    DEFF Research Database (Denmark)

    Kesper, Patrick; Berscheid, Lars; Wörgötter, Florentin;

    2015-01-01

    In this paper a generic approach to the SLAM (Simultaneous Localization and Mapping) problem is proposed. The approach is based on a probabilistic SLAM algorithm and employs only two portable sensors, an inertial measurement unit (IMU) and a laser range finder (LRF) to estimate the state and envi......In this paper a generic approach to the SLAM (Simultaneous Localization and Mapping) problem is proposed. The approach is based on a probabilistic SLAM algorithm and employs only two portable sensors, an inertial measurement unit (IMU) and a laser range finder (LRF) to estimate the state...... and environment of a robot. Scan-matching is applied to compensate for noisy IMU measurements. This approach does not require any robot-specific characteristics, e.g. wheel encoders or kinematic models. In principle, this minimal sensory setup can be mounted on different robot systems without major modifications...

  3. Development of a rabbit's urethral sphincter deficiency animal model for anatomical-functional evaluation

    Directory of Open Access Journals (Sweden)

    M. Skaff

    2012-02-01

    Full Text Available OBJECTIVE: The aim of the study was to develop a new durable animal model (using rabbits for anatomical-functional evaluation of urethral sphincter deficiency. MATERIALS AND METHODS: A total of 40 New Zealand male rabbits, weighting 2.500 kg to 3.100 kg, were evaluated to develop an incontinent animal model. Thirty-two animals underwent urethrolysis and 8 animals received sham operation. Before and at 2, 4, 8 and 12 weeks after urethrolysis or sham operation, it was performed cystometry and leak point pressure (LPP evaluation with different bladder distension volumes (10, 20, 30 mL. In each time point, 10 animals (8 from the study group and 2 from the sham group were sacrificed to harvest the bladder and urethra. The samples were evaluated by H&E and Masson's Trichrome to determine urethral morphology and collagen/smooth muscle density. RESULTS: Twelve weeks after urethrolysis, it was observed a significant decrease in LPP regardless the bladder volume (from 33.7 ± 6.6 to 12.8 ± 2.2 cmH2O. The histological analysis evidenced a decrease of 22% in smooth muscle density with a proportional increase in the collagen, vessels and elastin density (p < 0.01. CONCLUSIONS: Transabdominal urethrolysis develops urethral sphincter insufficiency in rabbits, with significant decrease in LPP associated with decrease of smooth muscle fibers and increase of collagen density. This animal model can be used to test autologous cell therapy for stress urinary incontinence treatment.

  4. The evolution of anatomical illustration and wax modelling in Italy from the 16th to early 19th centuries.

    Science.gov (United States)

    Riva, Alessandro; Conti, Gabriele; Solinas, Paola; Loy, Francesco

    2010-02-01

    Although the contribution to anatomical illustration by Vesalius and his followers has received much attention, less credit has been given to Veslingius and particularly Fabricius. By 1600, Fabricius had amassed more than 300 paintings that together made the Tabulae Pictae, a great atlas of anatomy that was highly admired by his contemporaries. Many of his new observations were incorporated into subsequent books, including those by Casserius, Spighelius, Harvey and Veslingius. Also of importance were the Tabulae by Eustachius (1552), which, although only published in 1714, greatly influenced anatomical wax modelling. In 1742, Pope Benedict XIV established a Museum of Anatomy in Bologna, entrusting to Ercole Lelli the creation of several anatomical preparations in wax. Felice Fontana realised that the production of a large number of models by the casting method would make cadaveric specimens superfluous for anatomical teaching and in 1771 he asked the Grand Duke to fund a wax-modelling workshop in Florence as part of the Natural History Museum, later known as La Specola. Fontana engaged Giuseppe Ferrini as his first modeller and then the 19-year-old Clemente Susini who, by his death in 1814, had superintended the production of, or personally made, more than 2000 models. In 1780, the Austrian Emperor Joseph II visited La Specola and ordered a great number of models for his Josephinum museum; these were made by Fontana with the help of Clemente Susini and supervised by the anatomist Paolo Mascagni. It is, however, in Cagliari that some of Susini's greatest waxes are to be found. These were made when he was free of Fontana's influence and were based on dissections made by Francesco Antonio Boi (University of Cagliari). Their distinctive anatomical features include the emphasis given to nerves and the absence of lymphatics in the brain, a mistake made on earlier waxes. The refined technical perfection of the anatomical details demonstrates the closeness of the

  5. Review and standardization of cell phone exposure calculations using the SAM phantom and anatomically correct head models

    Directory of Open Access Journals (Sweden)

    Kainz Wolfgang

    2004-10-01

    Full Text Available Abstract We reviewed articles using computational RF dosimetry to compare the Specific Anthropomorphic Mannequin (SAM to anatomically correct models of the human head. Published conclusions based on such comparisons have varied widely. We looked for reasons that might cause apparently similar comparisons to produce dissimilar results. We also looked at the information needed to adequately compare the results of computational RF dosimetry studies. We concluded studies were not comparable because of differences in definitions, models, and methodology. Therefore we propose a protocol, developed by an IEEE standards group, as an initial step in alleviating this problem. The protocol calls for a benchmark validation study comparing the SAM phantom to two anatomically correct models of the human head. It also establishes common definitions and reporting requirements that will increase the comparability of all computational RF dosimetry studies of the human head.

  6. Generic Procedure for Coupling the PHREEQC Geochemical Modeling Framework with Flow and Solute Transport Simulators

    Science.gov (United States)

    Wissmeier, L. C.; Barry, D. A.

    2009-12-01

    Computer simulations of water availability and quality play an important role in state-of-the-art water resources management. However, many of the most utilized software programs focus either on physical flow and transport phenomena (e.g., MODFLOW, MT3DMS, FEFLOW, HYDRUS) or on geochemical reactions (e.g., MINTEQ, PHREEQC, CHESS, ORCHESTRA). In recent years, several couplings between both genres of programs evolved in order to consider interactions between flow and biogeochemical reactivity (e.g., HP1, PHWAT). Software coupling procedures can be categorized as ‘close couplings’, where programs pass information via the memory stack at runtime, and ‘remote couplings’, where the information is exchanged at each time step via input/output files. The former generally involves modifications of software codes and therefore expert programming skills are required. We present a generic recipe for remotely coupling the PHREEQC geochemical modeling framework and flow and solute transport (FST) simulators. The iterative scheme relies on operator splitting with continuous re-initialization of PHREEQC and the FST of choice at each time step. Since PHREEQC calculates the geochemistry of aqueous solutions in contact with soil minerals, the procedure is primarily designed for couplings to FST’s for liquid phase flow in natural environments. It requires the accessibility of initial conditions and numerical parameters such as time and space discretization in the input text file for the FST and control of the FST via commands to the operating system (batch on Windows; bash/shell on Unix/Linux). The coupling procedure is based on PHREEQC’s capability to save the state of a simulation with all solid, liquid and gaseous species as a PHREEQC input file by making use of the dump file option in the TRANSPORT keyword. The output from one reaction calculation step is therefore reused as input for the following reaction step where changes in element amounts due to advection

  7. Scenario tree model for animal disease freedom framed in the OIE context using the example of a generic swine model for Aujeszky's disease in commercial swine in Canada.

    Science.gov (United States)

    Christensen, Jette; Vallières, André

    2016-01-01

    "Freedom from animal disease" is an ambiguous concept that may have a different meaning in trade and science. For trade alone, there are different levels of freedom from OIE listed diseases. A country can: be recognized by OIE to be "officially free"; self-declare freedom, with no official recognition by the OIE; or report animal disease as absent (no occurrence) in six-monthly reports. In science, we apply scenario tree models to calculate the probability of a population being free from disease at a given prevalence to provide evidence of freedom from animal disease. Here, we link science with application by describing how a scenario tree model may contribute to a country's claim of freedom from animal disease. We combine the idea of a standardized presentation of scenario tree models for disease freedom and having a similar model for two different animal diseases to suggest that a simple generic model may help veterinary authorities to build and evaluate scenario tree models for disease freedom. Here, we aim to develop a generic scenario tree model for disease freedom that is: animal species specific, population specific, and has a simple structure. The specific objectives were: to explore the levels of freedom described in the OIE Terrestrial Animal Health Code; to describe how scenario tree models may contribute to a country's claim of freedom from animal disease; and to present a generic swine scenario tree model for disease freedom in Canada's domestic (commercial) swine applied to Aujeszky's disease (AD). In particular, to explore how historical survey data, and data mining may affect the probability of freedom and to explore different sampling strategies. Finally, to frame the generic scenario tree model in the context of Canada's claim of freedom from AD. We found that scenario tree models are useful to support a country's claim of freedom either as "recognized officially free" or as part of a self-declaration but the models should not stand alone in a

  8. 3D Modeling of branching vessels from anatomical sketches: towards a new interactive teaching of anatomy: Interactive virtual blackboard.

    Science.gov (United States)

    Palombi, O; Pihuit, A; Cani, M-P

    2011-09-01

    Sketching is an intuitive way to explain spatial relationships between complex objects. The French community of Anatomists are used to teaching didactic lectures on a blackboard with their colored chalks. The increasing complexity of the sketches affords to the students an opportunity to work out a mental representation of anatomical structures in 3D. To help students perform this labored step, we present a new interactive blackboard which constructs plausible 3D models of branching vessels from a single sketch. We exploit the sketching conventions used in anatomical drawings to infer depth and curvature. We then model the set of branching vessels as a convolution surface generated by a graph of skeleton curves. Classic situations, focused on arteries, have been analyzed to manage vessels' curvatures, subdivisions and overlaps. Original sketches and 3D models are presented for each case. No specific training is required to use the interface. The anatomists have begun to embrace a new generation of 3D digital modeling applications as tools for anatomical teaching. We discuss the future use of this system as a step towards the interactive teaching of anatomy.

  9. Criteria for anatomical compatibility of the total artificial heart: computerized three-dimensional modeling of the cardiovascular anatomy.

    Science.gov (United States)

    Chatel, D; Martin-Bouyer, Y; Vicaut, E; Bouchoucha, H; Achard, F; Sablayrolles, J L; Carpentier, A

    1993-12-01

    A quantitative study of cardiovascular anatomy was performed by obtaining three-dimensional reconstructions from regular computed tomography scan images in 15 patients, all candidates for heart transplantation. Volumetric estimates of the cardiovascular structures were obtained from these three-dimensional reconstructions using data directly related to total artificial heart (TAH) implantations. By using computerized three-dimensional modeling of these structures, reproducible measurements of the parameters defining the shape and the anatomical connections of the intrathoracic space available for TAH implantation could be derived. The results are intended to be used for both technical and clinical applications such as computer-assisted drawing of the pericardial cavity and the anatomical connections (useful for improving the design of TAH) and combined statistical calculations (multiple regressions, cluster algorithm) of the measurement results, which will then enable the best selection to be made among two or three TAH models for each patient.

  10. A veterinary digital anatomical database.

    OpenAIRE

    Snell, J.R.; Green, R; Stott, G; Van Baerle, S.

    1991-01-01

    This paper describes the Veterinary Digital Anatomical Database Project. The purpose of the project is to investigate the construction and use of digitally stored anatomical models. We will be discussing the overall project goals and the results to date. Digital anatomical models are 3 dimensional, solid model representations of normal anatomy. The digital representations are electronically stored and can be manipulated and displayed on a computer graphics workstation. A digital database of a...

  11. Essential equivalence of the general equation for the nonequilibrium reversible-irreversible coupling (GENERIC) and steepest-entropy-ascent models of dissipation for nonequilibrium thermodynamics

    Science.gov (United States)

    Montefusco, Alberto; Consonni, Francesco; Beretta, Gian Paolo

    2015-04-01

    By reformulating the steepest-entropy-ascent (SEA) dynamical model for nonequilibrium thermodynamics in the mathematical language of differential geometry, we compare it with the primitive formulation of the general equation for the nonequilibrium reversible-irreversible coupling (GENERIC) model and discuss the main technical differences of the two approaches. In both dynamical models the description of dissipation is of the "entropy-gradient" type. SEA focuses only on the dissipative, i.e., entropy generating, component of the time evolution, chooses a sub-Riemannian metric tensor as dissipative structure, and uses the local entropy density field as potential. GENERIC emphasizes the coupling between the dissipative and nondissipative components of the time evolution, chooses two compatible degenerate structures (Poisson and degenerate co-Riemannian), and uses the global energy and entropy functionals as potentials. As an illustration, we rewrite the known GENERIC formulation of the Boltzmann equation in terms of the square root of the distribution function adopted by the SEA formulation. We then provide a formal proof that in more general frameworks, whenever all degeneracies in the GENERIC framework are related to conservation laws, the SEA and GENERIC models of the dissipative component of the dynamics are essentially interchangeable, provided of course they assume the same kinematics. As part of the discussion, we note that equipping the dissipative structure of GENERIC with the Leibniz identity makes it automatically SEA on metric leaves.

  12. Interpreting the effects of altered brain anatomical connectivity on fMRI functional connectivity: a role for computational neural modeling.

    Science.gov (United States)

    Horwitz, Barry; Hwang, Chuhern; Alstott, Jeff

    2013-01-01

    Recently, there have been a large number of studies using resting state fMRI to characterize abnormal brain connectivity in patients with a variety of neurological, psychiatric, and developmental disorders. However, interpreting what the differences in resting state fMRI functional connectivity (rsfMRI-FC) actually reflect in terms of the underlying neural pathology has proved to be elusive because of the complexity of brain anatomical connectivity. The same is the case for task-based fMRI studies. In the last few years, several groups have used large-scale neural modeling to help provide some insight into the relationship between brain anatomical connectivity and the corresponding patterns of fMRI-FC. In this paper we review several efforts at using large-scale neural modeling to investigate the relationship between structural connectivity and functional/effective connectivity to determine how alterations in structural connectivity are manifested in altered patterns of functional/effective connectivity. Because the alterations made in the anatomical connectivity between specific brain regions in the model are known in detail, one can use the results of these simulations to determine the corresponding alterations in rsfMRI-FC. Many of these simulation studies found that structural connectivity changes do not necessarily result in matching changes in functional/effective connectivity in the areas of structural modification. Often, it was observed that increases in functional/effective connectivity in the altered brain did not necessarily correspond to increases in the strength of the anatomical connection weights. Note that increases in rsfMRI-FC in patients have been interpreted in some cases as resulting from neural plasticity. These results suggest that this interpretation can be mistaken. The relevance of these simulation findings to the use of functional/effective fMRI connectivity as biomarkers for brain disorders is also discussed.

  13. Anatomical risk models for paravalvular leak and landing zone complications for balloon-expandable transcatheter aortic valve replacement.

    Science.gov (United States)

    Condado, Jose F; Corrigan, Frank E; Lerakis, Stamatios; Parastatidis, Ioannis; Stillman, Arthur E; Binongo, Jose N; Stewart, James; Mavromatis, Kreton; Devireddy, Chandan; Leshnower, Bradley; Guyton, Robert; Forcillo, Jessica; Patel, Ateet; Thourani, Vinod H; Block, Peter C; Babaliaros, Vasilis

    2017-05-04

    Though several anatomical characteristics have been reported separately as risk factors for paravalvular leak (PVL) and landing zone (LZ) complications after transcatheter aortic valve replacement (TAVR), multivariate risk models are needed. Patients that underwent balloon-expandable TAVR with multidetector cardiac computed tomography (MDCT) sizing were studied. MDCT images were analyzed and the association between anatomical factors and ≥mild PVL, ≥moderate PVL, and LZ complications (annular rupture, requirement of new permanent pacemaker, and coronary obstruction) was determined, and subsequently competing predictive models were developed and validated. A total of 316 consecutive TAVR patients were included. Median age was 82.0 years (74.0-87.0) and STS score was 8.3% (5.4-10.9). Factors associated with ≥mild PVL included TAVR with Sapien/Sapien XT vs. Sapien 3 (OR = 2.50, 95% CI = 1.24-5.07), LVOT nontubularity (OR = 1.02, 95% CI = 1.01-1.04), LZ calcification (OR = 1.01, 95% CI = 1.00-1.01), and low cover index (OR = 0.94, 95% CI = 0.91-0.96). Factors associated with LZ complications included LZ calcification (OR = 1.01, 95% CI 1.00-1.01), leaflet asymmetry (OR = 1.01, 95% CI 1.01-1.02), and cover index (OR = 1.09, 95% CI 1.03-1.14). Predictive models for ≥mild PVL (AUC = 0.71, 95% CI = 0.66-0.77), ≥moderate PVL (AUC = 0.75, 95% CI = 0.65-0.84), and LZ complications (AUC = 0.77, 95% CI = 0.67-0.87) were created using procedural details and anatomical data from the MDCT. Clinical variables were not included as they were poorly correlated with the occurrence of PVL and LZ complications. For each outcome, the area under the curve (AUC) of the multivariate model was superior to the model consisting only of individual factors. A model using procedural/anatomical characteristics derived from MDCT predicts ≥mild PVL, ≥moderate PVL, and LZ complications post-TAVR. Incorporation of

  14. Can key vegetation parameters be retrieved at the large-scale using LAI satellite products and a generic modelling approach ?

    Science.gov (United States)

    Dewaele, Helene; Calvet, Jean-Christophe; Carrer, Dominique; Laanaia, Nabil

    2016-04-01

    In the context of climate change, the need to assess and predict the impact of droughts on vegetation and water resources increases. The generic approaches permitting the modelling of continental surfaces at large-scale has progressed in recent decades towards land surface models able to couple cycles of water, energy and carbon. A major source of uncertainty in these generic models is the maximum available water content of the soil (MaxAWC) usable by plants which is constrained by the rooting depth parameter and unobservable at the large-scale. In this study, vegetation products derived from the SPOT/VEGETATION satellite data available since 1999 are used to optimize the model rooting depth over rainfed croplands and permanent grasslands at 1 km x 1 km resolution. The inter-annual variability of the Leaf Area Index (LAI) is simulated over France using the Interactions between Soil, Biosphere and Atmosphere, CO2-reactive (ISBA-A-gs) generic land surface model and a two-layer force-restore (FR-2L) soil profile scheme. The leaf nitrogen concentration directly impacts the modelled value of the maximum annual LAI. In a first step this parameter is estimated for the last 15 years by using an iterative procedure that matches the maximum values of LAI modelled by ISBA-A-gs to the highest satellite-derived LAI values. The Root Mean Square Error (RMSE) is used as a cost function to be minimized. In a second step, the model rooting depth is optimized in order to reproduce the inter-annual variability resulting from the drought impact on the vegetation. The evaluation of the retrieved soil rooting depth is achieved using the French agricultural statistics of Agreste. Retrieved leaf nitrogen concentrations are compared with values from previous studies. The preliminary results show a good potential of this approach to estimate these two vegetation parameters (leaf nitrogen concentration, MaxAWC) at the large-scale over grassland areas. Besides, a marked impact of the

  15. Three dimensional printing as an effective method of producing anatomically accurate models for studies in thermal ecology.

    Science.gov (United States)

    Watson, Charles M; Francis, Gamal R

    2015-07-01

    Hollow copper models painted to match the reflectance of the animal subject are standard in thermal ecology research. While the copper electroplating process results in accurate models, it is relatively time consuming, uses caustic chemicals, and the models are often anatomically imprecise. Although the decreasing cost of 3D printing can potentially allow the reproduction of highly accurate models, the thermal performance of 3D printed models has not been evaluated. We compared the cost, accuracy, and performance of both copper and 3D printed lizard models and found that the performance of the models were statistically identical in both open and closed habitats. We also find that 3D models are more standard, lighter, durable, and inexpensive, than the copper electroformed models.

  16. Generic folding and transition hierarchies for surface adsorption of hydrophobic-polar lattice model proteins

    Science.gov (United States)

    Li, Ying Wai; Wüst, Thomas; Landau, David P.

    2013-01-01

    The thermodynamic behavior and structural properties of hydrophobic-polar (HP) lattice proteins interacting with attractive surfaces are studied by means of Wang-Landau sampling. Three benchmark HP sequences (48mer, 67mer, and 103mer) are considered with different types of surfaces, each of which attract either all monomers, only hydrophobic (H) monomers, or only polar (P) monomers, respectively. The diversity of folding behavior in dependence of surface strength is discussed. Analyzing the combined patterns of various structural observables, such as, e.g., the derivatives of the numbers of surface contacts, together with the specific heat, we are able to identify generic categories of folding and transition hierarchies. We also infer a connection between these transition categories and the relative surface strengths, i.e., the ratio of the surface attractive strength to the interchain attraction among H monomers. The validity of our proposed classification scheme is reinforced by the analysis of additional benchmark sequences. We thus believe that the folding hierarchies and identification scheme are generic for HP proteins interacting with attractive surfaces, regardless of chain length, sequence, or surface attraction.

  17. A veterinary digital anatomical database.

    Science.gov (United States)

    Snell, J R; Green, R; Stott, G; Van Baerle, S

    1991-01-01

    This paper describes the Veterinary Digital Anatomical Database Project. The purpose of the project is to investigate the construction and use of digitally stored anatomical models. We will be discussing the overall project goals and the results to date. Digital anatomical models are 3 dimensional, solid model representations of normal anatomy. The digital representations are electronically stored and can be manipulated and displayed on a computer graphics workstation. A digital database of anatomical structures can be used in conjunction with gross dissection in teaching normal anatomy to first year students in the professional curriculum. The computer model gives students the opportunity to "discover" relationships between anatomical structures that may have been destroyed or may not be obvious in the gross dissection. By using a digital database, the student will have the ability to view and manipulate anatomical structures in ways that are not available through interactive video disk (IVD). IVD constrains the student to preselected views and sections stored on the disk.

  18. Compositional Design of a Generic Design Agent

    NARCIS (Netherlands)

    Brazier, F.M.T.; Jonker, C.M.; Treur, J.; Wijngaards, N.J.E.

    2001-01-01

    This paper presents a generic architecture for a design agent, to be used in an Internet environment. The design agent is based on an existing generic agent model, and includes a refinement of a generic model for design, in which strategic reasoning

  19. Prediction of air-fuel and oxy-fuel combustion through a generic gas radiation property model

    DEFF Research Database (Denmark)

    Yin, Chungen

    2017-01-01

    Thermal radiation plays an important role in heat transfer in combustion furnaces. The weighted-sum-of-gray-gases model (WSGGM), representing a good compromise between computational efficiency and accuracy, is commonly used in computational fluid dynamics (CFD) modeling of combustion processes...... for evaluating gaseous radiative properties. However, the WSGGMs still have some limitations in practical use, e.g., unable to naturally accommodate different combustion environments, difficult to accurately address the variations in species concentrations in a flame, and inconvenient to account for the impacts...... of participating species other than H2O and CO2. As a result, WSGGMs with different coefficients have been published for specific applications. In this paper, a reliable generic model for gaseous radiation property calculation, which is a computationally efficient exponential wide band model (E-EWBM) applicable...

  20. Implementing a generic method for bias correction in statistical models using random effects, with spatial and population dynamics examples

    DEFF Research Database (Denmark)

    Thorson, James T.; Kristensen, Kasper

    2016-01-01

    Statistical models play an important role in fisheries science when reconciling ecological theory with available data for wild populations or experimental studies. Ecological models increasingly include both fixed and random effects, and are often estimated using maximum likelihood techniques...... abundance relative to the conventional plug-in estimator, and also gives essentially identical estimates to a sample-based bias-correction estimator. The epsilon-method has been implemented by us as a generic option in the open-source Template Model Builder software, and could be adapted within other....... Quantities of biological or management interest ("derived quantities") are then often calculated as nonlinear functions of fixed and random effect estimates. However, the conventional "plug-in" estimator for a derived quantity in a maximum likelihood mixed-effects model will be biased whenever the estimator...

  1. Accurate alignment of functional EPI data to anatomical MRI using a physics-based distortion model.

    Science.gov (United States)

    Studholme, C; Constable, R T; Duncan, J S

    2000-11-01

    Mapping of functional magnetic resonance imaging (fMRI) to conventional anatomical MRI is a valuable step in the interpretation of fMRI activations. One of the main limits on the accuracy of this alignment arises from differences in the geometric distortion induced by magnetic field inhomogeneity. This paper describes an approach to the registration of echo planar image (EPI) data to conventional anatomical images which takes into account this difference in geometric distortion. We make use of an additional spin echo EPI image and use the known signal conservation in spin echo distortion to derive a specialized multimodality nonrigid registration algorithm. We also examine a plausible modification using log-intensity evaluation of the criterion to provide increased sensitivity in areas of low EPI signal. A phantom-based imaging experiment is used to evaluate the behavior of the different criteria, comparing nonrigid displacement estimates to those provided by a imagnetic field mapping acquisition. The algorithm is then applied to a range of nine brain imaging studies illustrating global and local improvement in the anatomical alignment and localization of fMRI activations.

  2. Incorporating a Generic Model of Subcutaneous Insulin Absorption into the AIDA v4 Diabetes Simulator 3. Early Plasma Insulin Determinations

    Science.gov (United States)

    Lehmann, Eldon D.; Tarín, Cristina; Bondia, Jorge; Teufel, Edgar; Deutsch, Tibor

    2009-01-01

    Introduction AIDA is an interactive educational diabetes simulator that has been available without charge via the Internet for over 12 years. Recent articles have described the incorporation of a novel generic model of insulin absorption into AIDA as a way of enhancing its capabilities. The basic model components to be integrated have been overviewed, with the aim being to provide simulations of regimens utilizing insulin analogues, as well as insulin doses greater than 40 IU (the current upper limit within the latest release of AIDA [v4.3a]). Some preliminary calculated insulin absorption results have also recently been described. Methods This article presents the first simulated plasma insulin profiles from the integration of the generic subcutaneous insulin absorption model, and the currently implemented model in AIDA for insulin disposition. Insulin absorption has been described by the physiologically based model of Tarín and colleagues. A single compartment modeling approach has been used to specify how absorbed insulin is distributed in, and eliminated from, the human body. To enable a numerical solution of the absorption model, a spherical subcutaneous depot for the injected insulin dose has been assumed and spatially discretized into shell compartments with homogeneous concentrations, having as its center the injection site. The number of these compartments will depend on the dose and type of insulin. Insulin inflow arises as the sum of contributions to the different shells. For this report the first bench testing of plasma insulin determinations has been done. Results Simulated plasma insulin profiles are provided for currently available insulin preparations, including a rapidly acting insulin analogue (e.g., lispro/Humalog or aspart/Novolog), a short-acting (regular) insulin preparation (e.g., Actrapid), intermediate-acting insulins (both Semilente and neutral protamine Hagedorn types), and a very long-acting insulin analogue (e.g., glargine/Lantus), as

  3. Developing a Generic Risk Assessment Simulation Modelling Software Tool for Assessing the Risk of Foot and Mouth Virus Introduction.

    Science.gov (United States)

    Tameru, B; Gebremadhin, B; Habtemariam, T; Nganwa, D; Ayanwale, O; Wilson, S; Robnett, V; Wilson, W

    2008-06-01

    Foot and Mouth disease (FMD) is a highly contagious viral disease that affects all cloven-hoofed animals. Because of its devastating effects on the agricultural industry, many countries take measures to stop the introduction of FMD virus into their countries. Decision makers at multiple levels of the United States Department of Agriculture (USDA) use Risk Assessments (RAs) (both quantitative and qualitative) to make better and more informed scientifically based decisions to prevent the accidental or intentional introduction of the disease. There is a need for a generic RA that can be applied to any country (whether FMD free or non-FMD free) and for any product (FMD infected animals and animal products). We developed a user-friendly generic RA tool (software) that can be used to conduct and examine different scenarios of quantitative/qualitative risk assessments for the different countries with their varying FMD statuses in relation to reintroduction of FMD virus into the USA. The program was written in Microsoft Visual Basic 6.0 (Microsoft Corporation, Redmond, Washington, USA). The @Risk 6.1 Developer Kit (RDK) and @Risk 6.1 Best Fit Kit library (Palisade Corporation, Newfield, NY.USA) was used to build Monte Carlo simulation models. Microsoft Access 2000 (Microsoft Corporation, Redmond, Washington, USA) was used and SQL to query the data. Different input probability distributions can be selected for the nodes in the scenario tree and different output for each end-state of the simulation is given in different graphical formats and statistical values are used in describing the likelihood of FMD virus introduction. Sensitivity Analysis in determining which input factor has more effect on the total risk outputs is also given. The developed generic RA tools can be eventually extended and modified to conduct RAs for other animal diseases and animal products.

  4. Vibratory response of a precision double-multi-layer monochromator positioning system using a generic modeling program with experimental verification.

    Energy Technology Data Exchange (ETDEWEB)

    Barraza, J.

    1998-07-29

    A generic vibratory response-modeling program has been developed as a tool for designing high-precision optical positioning systems. The systems are modeled as rigid-body structures connected by linear non-rigid elements such as complex actuators and bearings. The full dynamic properties of each non-rigid element are determined experimentally or theoretically, then integrated into the program as inertial and stiffness matrices. Thus, it is possible to have a suite of standardize structural elements for modeling many different positioning systems that use standardized components. This paper will present the application of this program to a double-multi-layer monochromator positioning system that utilizes standardized components. Calculated results are compared to experimental modal analysis results.

  5. Steady and Periodic Pressure Measurements on a Generic Helicopter Fuselage Model in the Presence of a Rotor

    Science.gov (United States)

    Mineck, Raymond E.; Gorton, Susan A.

    2000-01-01

    A wind tunnel test of a generic helicopter fuselage model with an independently mounted rotor has been conducted to obtain steady and periodic pressure data on the helicopter body. The model was tested at four advance ratios and three thrust coefficients. The periodic unsteady pressure coefficients are marked by four peaks associated with the passage of the four rotor blades. Blade passage effects are largest on the nose and tail boom of the model. The magnitude of the pulse increases with rotor thrust coefficient. Tabular listings of the unsteady pressure data are included to permit independent analysis. A CD-rom containing the steady and unsteady pressure data presented in the report is available from the authors.

  6. A generic model-based methodology for quantification of mass transfer limitations in microreactors

    DEFF Research Database (Denmark)

    Van Daele, Timothy; Fernandes del Pozo, David; Van Hauwermeiren, Daan

    2016-01-01

    Microreactors are becoming more popular in the biocatalytic field to speed up reactions and thus achieve process intensification. However, even these small-scale reactors can suffer from mass transfer limitations. Traditionally, dimensionless numbers such as the second Damköhler number are used...... to determine whether the reaction is either kinetically or mass transfer limited. However, these dimensionless numbers only give a qualitative measure of the extent of the mass transfer limitation, and are only applicable to simple reactor configurations. In practice, this makes it difficult to rapidly...... quantify the importance of such mass transfer limitations and compare different reactor configurations. This paper presents a novel generic methodology to quantify mass transfer limitations. It was applied to two microreactor configurations: a microreactor with immobilised enzyme at the wall and a Y...

  7. 76 FR 54507 - Proposed Generic Communication; Draft NRC Generic Letter 2011-XX: Seismic Risk Evaluations for...

    Science.gov (United States)

    2011-09-01

    ... COMMISSION Proposed Generic Communication; Draft NRC Generic Letter 2011-XX: Seismic Risk Evaluations for... the effects of natural phenomena, including earthquakes, without losing the capability to perform... Electric Power Research Institute models to estimate earthquake ground motion and updated models...

  8. Review on Generic Model for Wind Power Generation%风力发电统一模型评述

    Institute of Scientific and Technical Information of China (English)

    张磊; 朱凌志; 陈宁; 姜达军; 刘艳章; 赵大伟

    2016-01-01

    Due to some excellent characteristics,such as non-proprietary,modular,parametric,cross-platform portability and compatibility,high scalability,etc.,generic model for renewable energy generation has been attached more and more attention in renewable energy grid-connected analysis,and along with persistent optimization and improvement,its adaptability and generality will obtain ever-promotion.The generic model constitutes the research foundation for renewable energy generation models.The classification of wind power generators is provided firstly,and then the more applicable second generation generic models,are reviewed,which is grid-connected and includes power electronic devices,and the structures,parameters and validation of the model are emphasized,and its problems to be improved are pointed out.The theoretical analysis is provided to facilitate understanding the improvement,and the subsequent research points are envisioned for the model precision and application scope.%得益于公开、模块化、参数化、可跨平台移植、扩展性好等优点,新能源发电统一模型已在新能源接入分析和研究中得到广泛关注。随着逐步优化改进,其适应性和统一性也在不断提升。风力发电统一模型是新能源发电模型统一化研究的基础。文中首先给出风电机组的分类,在此基础上,分功能模块介绍具有更强适用性的直接并网和含电力电子设备并网形式的第二代风力发电统一模型,重点对模型结构、参数及验证情况进行评述,指出模型有待改进的地方,并针对部分模块的改进,给出理论分析。最后,在总结风力发电统一模型现状的基础上,对模型的后续研究进行展望。

  9. Generic Kalman Filter Software

    Science.gov (United States)

    Lisano, Michael E., II; Crues, Edwin Z.

    2005-01-01

    The Generic Kalman Filter (GKF) software provides a standard basis for the development of application-specific Kalman-filter programs. Historically, Kalman filters have been implemented by customized programs that must be written, coded, and debugged anew for each unique application, then tested and tuned with simulated or actual measurement data. Total development times for typical Kalman-filter application programs have ranged from months to weeks. The GKF software can simplify the development process and reduce the development time by eliminating the need to re-create the fundamental implementation of the Kalman filter for each new application. The GKF software is written in the ANSI C programming language. It contains a generic Kalman-filter-development directory that, in turn, contains a code for a generic Kalman filter function; more specifically, it contains a generically designed and generically coded implementation of linear, linearized, and extended Kalman filtering algorithms, including algorithms for state- and covariance-update and -propagation functions. The mathematical theory that underlies the algorithms is well known and has been reported extensively in the open technical literature. Also contained in the directory are a header file that defines generic Kalman-filter data structures and prototype functions and template versions of application-specific subfunction and calling navigation/estimation routine code and headers. Once the user has provided a calling routine and the required application-specific subfunctions, the application-specific Kalman-filter software can be compiled and executed immediately. During execution, the generic Kalman-filter function is called from a higher-level navigation or estimation routine that preprocesses measurement data and post-processes output data. The generic Kalman-filter function uses the aforementioned data structures and five implementation- specific subfunctions, which have been developed by the user on

  10. Towards models of gravitational waveforms from generic binaries: A simple approximate mapping between precessing and non-precessing inspiral signals

    CERN Document Server

    Schmidt, Patricia; Husa, Sascha

    2012-01-01

    One of the greatest theoretical challenges in the build-up to the era of second-generation gravitational-wave detectors is the modeling of generic binary waveforms. We introduce an approximation that has the potential to significantly simplify this problem. We show that generic precessing-binary inspiral waveforms (covering a seven-dimensional parameter space) can be mapped to only a two-dimensional space of non-precessing binaries, characterized by the mass ratio and a single effective total spin. The mapping consists of a time-dependent rotation of the waveforms into the quadrupole-aligned frame, and is extremely accurate (matches $> 0.99$ with parameter biases in the total spin of $\\Delta \\chi \\leq 0.04$), even in the case of transitional precession. In addition, we demonstrate a simple method to construct hybrid post-Newtonian--numerical-relativity precessing-binary waveforms in the quadrupole-aligned frame, and provide evidence that our approximate mapping can be used all the way to the merger. Finally, ...

  11. The missing cavities in the SEEDS polarized scattered light images of transitional protoplanetary disks: a generic disk model

    CERN Document Server

    Dong, R; Zhu, Z; Hartmann, L; Whitney, B; Brandt, T; Muto, T; Hashimoto, J; Grady, C; Follette, K; Kuzuhara, M; Tanii, R; Itoh, Y; Thalmann, C; Wisniewski, J; Mayama, S; Janson, M; Abe, L; Brandner, W; Carson, J; Egner, S; Feldt, M; Goto, M; Guyon, O; Hayano, Y; Hayashi, M; Hayashi, S; Henning, T; Hodapp, K W; Honda, M; Inutsuka, S; Ishii, M; Iye, M; Kandori, R; Knapp, G R; Kudo, T; Kusakabe, N; Matsuo, T; McElwain, M W; Miyama, S; Morino, J -I; Moro-Martin, A; Nishimura, T; Pyo, T -S; Suto, H; Suzuki, R; Takami, M; Takato, N; Terada, H; Tomono, D; Turner, E L; Watanabe, M; Yamada, T; Takami, H; Usuda, T; Tamura, M

    2012-01-01

    Transitional circumstellar disks around young stellar objects have a distinctive infrared deficit around 10 microns in their Spectral Energy Distributions (SED), recently measured by the Spitzer Infrared Spectrograph (IRS), suggesting dust depletion in the inner regions. These disks have been confirmed to have giant central cavities by imaging of the submillimeter (sub-mm) continuum emission using the Submillimeter Array (SMA). However, the polarized near-infrared scattered light images for most objects in a systematic IRS/SMA cross sample, obtained by HiCIAO on the Subaru telescope, show no evidence for the cavity, in clear contrast with SMA and Spitzer observations. Radiative transfer modeling indicates that many of these scattered light images are consistent with a smooth spatial distribution for micron-sized grains, with little discontinuity in the surface density of the micron-sized grains at the cavity edge. Here we present a generic disk model that can simultaneously account for the general features in...

  12. Some theoretical models and constructs generic to substance abuse prevention programs for adolescents: possible relevance and limitations for problem gambling.

    Science.gov (United States)

    Evans, Richard I

    2003-01-01

    For the past several years the author and his colleagues have explored the area of how social psychological constructs and theoretical models can be applied to the prevention of health threatening behaviors in adolescents. In examining the need for the development of gambling prevention programs for adolescents, it might be of value to consider the application of such constructs and theoretical models as a foundation to the development of prevention programs in this emerging problem behavior among adolescents. In order to provide perspective to the reader, the present paper reviews the history of various psychosocial models and constructs generic to programs directed at prevention of substance abuse in adolescents. A brief history of some of these models, possibly most applicable to gambling prevention programs, are presented. Social inoculation, reasoned action, planned behavior, and problem behavior theory, are among those discussed. Some deficits of these models, are also articulated. How such models may have relevance to developing programs for prevention of problem gambling in adolescents is also discussed. However, the inherent differences between gambling and more directly health threatening behaviors such as substance abuse must, of course, be seriously considered in utilizing such models. Most current gambling prevention programs have seldom been guided by theoretical models. Developers of gambling prevention programs should consider theoretical foundations, particularly since such foundations not only provide a guide for programs, but may become critical tools in evaluating their effectiveness.

  13. Quantitative modeling of the accuracy in registering preoperative patient-specific anatomic models into left atrial cardiac ablation procedures

    Energy Technology Data Exchange (ETDEWEB)

    Rettmann, Maryam E., E-mail: rettmann.maryam@mayo.edu; Holmes, David R.; Camp, Jon J.; Cameron, Bruce M.; Robb, Richard A. [Biomedical Imaging Resource, Mayo Clinic College of Medicine, Rochester, Minnesota 55905 (United States); Kwartowitz, David M. [Department of Bioengineering, Clemson University, Clemson, South Carolina 29634 (United States); Gunawan, Mia [Department of Biochemistry and Molecular and Cellular Biology, Georgetown University, Washington D.C. 20057 (United States); Johnson, Susan B.; Packer, Douglas L. [Division of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota 55905 (United States); Dalegrave, Charles [Clinical Cardiac Electrophysiology, Cardiology Division Hospital Sao Paulo, Federal University of Sao Paulo, 04024-002 Brazil (Brazil); Kolasa, Mark W. [David Grant Medical Center, Fairfield, California 94535 (United States)

    2014-02-15

    Purpose: In cardiac ablation therapy, accurate anatomic guidance is necessary to create effective tissue lesions for elimination of left atrial fibrillation. While fluoroscopy, ultrasound, and electroanatomic maps are important guidance tools, they lack information regarding detailed patient anatomy which can be obtained from high resolution imaging techniques. For this reason, there has been significant effort in incorporating detailed, patient-specific models generated from preoperative imaging datasets into the procedure. Both clinical and animal studies have investigated registration and targeting accuracy when using preoperative models; however, the effect of various error sources on registration accuracy has not been quantitatively evaluated. Methods: Data from phantom, canine, and patient studies are used to model and evaluate registration accuracy. In the phantom studies, data are collected using a magnetically tracked catheter on a static phantom model. Monte Carlo simulation studies were run to evaluate both baseline errors as well as the effect of different sources of error that would be present in a dynamicin vivo setting. Error is simulated by varying the variance parameters on the landmark fiducial, physical target, and surface point locations in the phantom simulation studies. In vivo validation studies were undertaken in six canines in which metal clips were placed in the left atrium to serve as ground truth points. A small clinical evaluation was completed in three patients. Landmark-based and combined landmark and surface-based registration algorithms were evaluated in all studies. In the phantom and canine studies, both target registration error and point-to-surface error are used to assess accuracy. In the patient studies, no ground truth is available and registration accuracy is quantified using point-to-surface error only. Results: The phantom simulation studies demonstrated that combined landmark and surface-based registration improved

  14. Anatomic and histological analysis in a goat model used for maxillary sinus floor augmentation with simultaneous implant placement.

    Science.gov (United States)

    Derong, Zou; Lian, Guo; Jiayu, Lu; Xiuli, Zhang; Zhiyuan, Zhang; Xinquan, Jiang

    2010-01-01

    The aim of the present study was to carry out an anatomic survey on the goat maxillary sinus in order to provide accurate and definite anatomic parameters for the design of sinus floor elevation and dental implantation studies in this valuable preclinic animal model. The anatomic topographic structure of the maxillary sinuses was studied bilaterally in 10 adult goats by a gross survey as well as a histological analysis with parasagittal or coronal sections. Then following parameters were defined and measured: (1) maxillary alveolar height (MAH): vertical height from the alveolar crest to the sinus floor; (2) sinus lateral floor width (SLFW): horizontal distance from the lateral border of the anteroposterior bone crest to the sinus lateral wall; (3) infraorbital canal diameter (ICD); and (4) maxillary sinus volume (MSV): the volume occupied by water injected into the sinus. The data were presented with mean + or - SD on both sides. The goat has a maxillary sinus similar to humans, with a slender pyramidal shape that pneumatizes the entire maxilla, and a sinus wall covered with a mucosal lining. From the maxillary sinus floor, there is an anteroposterior bone crest protruding with the infraorbital canal enveloped. It divides the maxillary sinus floor into two parts. The SLFW of the lateral part of the maxillary sinus floor becomes broader, about 5.905 + or - 1.475 mm in the third premolar site, and the MAH increases towards the posterior area, where the maxillary sinus floor is close to the related teeth roots. According to original metrical data, we also proposed a possible operation procedure for sinus floor augmentation. There is enough space in the lateral floor of the maxillary sinus for dental implantation, and the third premolar area might be a suitable position suggested for maxillary sinus augmentation with simultaneous implant placement in a goat model.

  15. Technical Note: A generic law-of-the-minimum flux limiter for simulating substrate limitation in biogeochemical models

    Directory of Open Access Journals (Sweden)

    J. Y. Tang

    2015-08-01

    Full Text Available We present a generic flux limiter to account for mass limitations from an arbitrary number of substrates in a biogeochemical reaction network. The flux limiter is based on the observation that substrate (e.g., nitrogen, phosphorus limitation in biogeochemical models can be represented as to ensure mass conservative and non-negative numerical solutions to the governing ordinary differential equations. Application of the flux limiter includes two steps: (1 formulate the biogeochemical processes with a matrix of stoichiometric coefficients and (2 apply Liebig's law of the minimum using the dynamic stoichiometric relationship of the reactants. This approach contrasts with the ad hoc down-regulation approaches that are implemented in many existing models (such as CLM4.5 and the ACME (Accelerated Climate Modeling for Energy Land Model (ALM of carbon and nutrient interactions, which are error prone when adding new processes, even for experienced modelers. Through an example implementation with a Century-like decomposition model that includes carbon, nitrogen, and phosphorus, we show that our approach (1 produced almost identical results to that from the ad hoc down-regulation approaches under non-limiting nutrient conditions; and (2 properly resolved the negative solutions under substrate-limited conditions where the simple clipping approach failed; and (3 successfully avoided the potential conceptual ambiguities that are implied by those ad hoc down-regulation approaches. We expect our approach will make future biogeochemical models easier to improve and more robust.

  16. A multi-segment foot model based on anatomically registered technical coordinate systems: method repeatability in pediatric feet.

    Science.gov (United States)

    Saraswat, Prabhav; MacWilliams, Bruce A; Davis, Roy B

    2012-04-01

    Several multi-segment foot models to measure the motion of intrinsic joints of the foot have been reported. Use of these models in clinical decision making is limited due to lack of rigorous validation including inter-clinician, and inter-lab variability measures. A model with thoroughly quantified variability may significantly improve the confidence in the results of such foot models. This study proposes a new clinical foot model with the underlying strategy of using separate anatomic and technical marker configurations and coordinate systems. Anatomical landmark and coordinate system identification is determined during a static subject calibration. Technical markers are located at optimal sites for dynamic motion tracking. The model is comprised of the tibia and three foot segments (hindfoot, forefoot and hallux) and inter-segmental joint angles are computed in three planes. Data collection was carried out on pediatric subjects at two sites (Site 1: n=10 subjects by two clinicians and Site 2: five subjects by one clinician). A plaster mold method was used to quantify static intra-clinician and inter-clinician marker placement variability by allowing direct comparisons of marker data between sessions for each subject. Intra-clinician and inter-clinician joint angle variability were less than 4°. For dynamic walking kinematics, intra-clinician, inter-clinician and inter-laboratory variability were less than 6° for the ankle and forefoot, but slightly higher for the hallux. Inter-trial variability accounted for 2-4° of the total dynamic variability. Results indicate the proposed foot model reduces the effects of marker placement variability on computed foot kinematics during walking compared to similar measures in previous models.

  17. Development and implementation of a generic analysis template for structural-thermal-optical-performance modeling

    Science.gov (United States)

    Scola, Salvatore; Stavely, Rebecca; Jackson, Trevor; Boyer, Charlie; Osmundsen, Jim; Turczynski, Craig; Stimson, Chad

    2016-09-01

    Performance-related effects of system level temperature changes can be a key consideration in the design of many types of optical instruments. This is especially true for space-based imagers, which may require complex thermal control systems to maintain alignment of the optical components. Structural-Thermal-Optical-Performance (STOP) analysis is a multi-disciplinary process that can be used to assess the performance of these optical systems when subjected to the expected design environment. This type of analysis can be very time consuming, which makes it difficult to use as a trade study tool early in the project life cycle. In many cases, only one or two iterations can be performed over the course of a project. This limits the design space to best practices since it may be too difficult, or take too long, to test new concepts analytically. In order to overcome this challenge, automation, and a standard procedure for performing these studies is essential. A methodology was developed within the framework of the Comet software tool that captures the basic inputs, outputs, and processes used in most STOP analyses. This resulted in a generic, reusable analysis template that can be used for design trades for a variety of optical systems. The template captures much of the upfront setup such as meshing, boundary conditions, data transfer, naming conventions, and post-processing, and therefore saves time for each subsequent project. A description of the methodology and the analysis template is presented, and results are described for a simple telescope optical system.

  18. Development and Implementation of a Generic Analysis Template for Structural-Thermal-Optical-Performance Modeling

    Science.gov (United States)

    Scola, Salvatore; Stavely, Rebecca; Jackson, Trevor; Boyer, Charlie; Osmundsen, Jim; Turczynski, Craig; Stimson, Chad

    2016-01-01

    Performance-related effects of system level temperature changes can be a key consideration in the design of many types of optical instruments. This is especially true for space-based imagers, which may require complex thermal control systems to maintain alignment of the optical components. Structural-Thermal-Optical-Performance (STOP) analysis is a multi-disciplinary process that can be used to assess the performance of these optical systems when subjected to the expected design environment. This type of analysis can be very time consuming, which makes it difficult to use as a trade study tool early in the project life cycle. In many cases, only one or two iterations can be performed over the course of a project. This limits the design space to best practices since it may be too difficult, or take too long, to test new concepts analytically. In order to overcome this challenge, automation, and a standard procedure for performing these studies is essential. A methodology was developed within the framework of the Comet software tool that captures the basic inputs, outputs, and processes used in most STOP analyses. This resulted in a generic, reusable analysis template that can be used for design trades for a variety of optical systems. The template captures much of the upfront setup such as meshing, boundary conditions, data transfer, naming conventions, and post-processing, and therefore saves time for each subsequent project. A description of the methodology and the analysis template is presented, and results are described for a simple telescope optical system.

  19. ERSEM 15.06: a generic model for marine biogeochemistry and the ecosystem dynamics of the lower trophic levels

    Science.gov (United States)

    Butenschön, Momme; Clark, James; Aldridge, John N.; Icarus Allen, Julian; Artioli, Yuri; Blackford, Jeremy; Bruggeman, Jorn; Cazenave, Pierre; Ciavatta, Stefano; Kay, Susan; Lessin, Gennadi; van Leeuwen, Sonja; van der Molen, Johan; de Mora, Lee; Polimene, Luca; Sailley, Sevrine; Stephens, Nicholas; Torres, Ricardo

    2016-04-01

    The European Regional Seas Ecosystem Model (ERSEM) is one of the most established ecosystem models for the lower trophic levels of the marine food web in the scientific literature. Since its original development in the early nineties it has evolved significantly from a coastal ecosystem model for the North Sea to a generic tool for ecosystem simulations from shelf seas to the global ocean. The current model release contains all essential elements for the pelagic and benthic parts of the marine ecosystem, including the microbial food web, the carbonate system, and calcification. Its distribution is accompanied by a testing framework enabling the analysis of individual parts of the model. Here we provide a detailed mathematical description of all ERSEM components along with case studies of mesocosm-type simulations, water column implementations, and a brief example of a full-scale application for the north-western European shelf. Validation against in situ data demonstrates the capability of the model to represent the marine ecosystem in contrasting environments.

  20. Analysis and Development of the Generic Maintenance Management Process Modeling for the Preservation of Heritage School Buildings

    Directory of Open Access Journals (Sweden)

    A Z. A. Akasah

    2009-12-01

    Full Text Available Preservation of heritage school buildings requires special maintenance management practices. A thorough understanding of the maintenance management process is essential in ensuring effective maintenance practices can be instituted. The aim of this paper was to develop a generic process model that will promote the understanding of an effective management of maintenance process for heritage school buildings. A process model for the Maintenance Management of Heritage School Buildings (MMHSB was developed using the Integration Definition for Function Modeling (IDEF0 system through an iterative process. The initial MMHSB process model was submitted to a team of management experts from the Malaysian Ministry of Arts and Heritage and the Ministry of Education Malaysia for verifications. Based on their feedbacks the initial model was refined and a proposed model was developed. From the second verification, the feed back received formed the basis for the final model. The final model elucidates the items for the input, mechanism, control and output elements that are critical in the maintenance management of heritage school buildings. The model also redefines the existing scope of responsibilities of the Headmasters’ and Senior Assistants’ in the management of maintenance. The perceived effectiveness of the model by potential users was surveyed using a selected number of administrators from potentially recognized heritage schools. The results indicated that the process model is perceived as being helpful in clarifying the maintenance management process of heritage school buildings and is useful in changing the current reactive management practices to that of a more proactive practice. In conclusion, it is believed that the MMHSB Process Model is helpful in promoting the understanding of the maintenance management process which would lead to improve preservation practices of heritage school buildings.

  1. The Hazard Analysis and Critical Control Points (HACCP) generic model for the production of Thai fermented pork sausage (Nham).

    Science.gov (United States)

    Paukatong, K V; Kunawasen, S

    2001-01-01

    Nham is a traditional Thai fermented pork sausage. The major ingredients of Nham are ground pork meat and shredded pork rind. Nham has been reported to be contaminated with Salmonella spp., Staphylococcus aureus, and Listeria monocytogenes. Therefore, it is a potential cause of foodborne diseases for consumers. A Hazard Analysis and Critical Control Points (HACCP) generic model has been developed for the Nham process. Nham processing plants were observed and a generic flow diagram of Nham processes was constructed. Hazard analysis was then conducted. Other than microbial hazards, the pathogens previously found in Nham, sodium nitrite and metal were identified as chemical and physical hazards in this product, respectively. Four steps in the Nham process have been identified as critical control points. These steps are the weighing of the nitrite compound, stuffing, fermentation, and labeling. The chemical hazard of nitrite must be controlled during the weighing step. The critical limit of nitrite levels in the Nham mixture has been set at 100-200 ppm. This level is high enough to control Clostridium botulinum but does not cause chemical hazards to the consumer. The physical hazard from metal clips could be prevented by visual inspection of every Nham product during stuffing. The microbiological hazard in Nham could be reduced in the fermentation process. The critical limit of the pH of Nham was set at lower than 4.6. Since this product is not cooked during processing, finally, educating the consumer, by providing information on the label such as "safe if cooked before consumption", could be an alternative way to prevent the microbiological hazards of this product.

  2. Researching the effect of the practical applications performed with cadaver dissection and anatomical models on anatomy education

    Directory of Open Access Journals (Sweden)

    Vedat Sabancıoğulları

    2016-12-01

    Full Text Available Objective: The most important element in providing good quality of healthcare is well training of healthcare staff, particularly doctors. The way of being a good and successful healthcare staff is to learn the human anatomy accurately and permanently. Practical applications as well as theoretical courses are also highly important in learning human anatomy. In classical anatomy education, using cadaver is accepted to be indispensable. However, along with the new medical faculties, there has been an increase in the shortage of cadaver, and anatomy practices have mainly begun to be carried out on models or mock-ups. Therefore, we aimed to study with anatomic models in practical applications and to research the effect of cadaver dissection on learning anatomy. Method: In this study including 120-second grade students that their achievement levels are close together and participating in the theoretical courses of anatomy in medical faculty during 2015 – 2016 academic year. To realize this, students were divided into four groups (1st group were include students only listening to theoretical course, 2nd group theoretical course and performing application with anatomic models, 3rd group theoretical course and performing application with cadaver dissection, and 4th group theoretical course and performing application with anatomic models and cadaver dissection of 30 people. Degree of students’ understanding the subject was detected with written and practical exams consists of 10 questions after the theoretical and practical courses on each committee. The resulting data are loaded to SPSS 22.0 software and statistical evaluation One-way ANOVA, Mann-Whitney, chi-square test was used. Results: The average of students who practice on both models and cadavers were statistically significant (p 0.05. Conclusions: The results obtained from our study indicate that anatomy practical training is carried out with the dissection of cadavers that made it easier to

  3. Evaluation by medical students of the educational value of multi-material and multi-colored three-dimensional printed models of the upper limb for anatomical education.

    Science.gov (United States)

    Mogali, Sreenivasulu Reddy; Yeong, Wai Yee; Tan, Heang Kuan Joel; Tan, Gerald Jit Shen; Abrahams, Peter H; Zary, Nabil; Low-Beer, Naomi; Ferenczi, Michael Alan

    2017-05-19

    For centuries, cadaveric material has been the cornerstone of anatomical education. For reasons of changes in curriculum emphasis, cost, availability, expertise, and ethical concerns, several medical schools have replaced wet cadaveric specimens with plastinated prosections, plastic models, imaging, and digital models. Discussions about the qualities and limitations of these alternative teaching resources are on-going. We hypothesize that three-dimensional printed (3DP) models can replace or indeed enhance existing resources for anatomical education. A novel multi-colored and multi-material 3DP model of the upper limb was developed based on a plastinated upper limb prosection, capturing muscles, nerves, arteries and bones with a spatial resolution of ∼1 mm. This study aims to examine the educational value of the 3DP model from the learner's point of view. Students (n = 15) compared the developed 3DP models with the plastinated prosections, and provided their views on their learning experience using 3DP models using a survey and focus group discussion. Anatomical features in 3DP models were rated as accurate by all students. Several positive aspects of 3DP models were highlighted, such as the color coding by tissue type, flexibility and that less care was needed in the handling and examination of the specimen than plastinated specimens which facilitated the appreciation of relations between the anatomical structures. However, students reported that anatomical features in 3DP models are less realistic compared to the plastinated specimens. Multi-colored, multi-material 3DP models are a valuable resource for anatomical education and an excellent adjunct to wet cadaveric or plastinated prosections. Anat Sci Educ. © 2017 American Association of Anatomists. © 2017 American Association of Anatomists.

  4. Generic method for automatic bladder segmentation on cone beam CT using a patient-specific bladder shape model

    Energy Technology Data Exchange (ETDEWEB)

    Schoot, A. J. A. J. van de, E-mail: a.j.schootvande@amc.uva.nl; Schooneveldt, G.; Wognum, S.; Stalpers, L. J. A.; Rasch, C. R. N.; Bel, A. [Department of Radiation Oncology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam (Netherlands); Hoogeman, M. S. [Department of Radiation Oncology, Daniel den Hoed Cancer Center, Erasmus Medical Center, Groene Hilledijk 301, 3075 EA Rotterdam (Netherlands); Chai, X. [Department of Radiation Oncology, Stanford University School of Medicine, 875 Blake Wilbur Drive, Palo Alto, California 94305 (United States)

    2014-03-15

    Purpose: The aim of this study is to develop and validate a generic method for automatic bladder segmentation on cone beam computed tomography (CBCT), independent of gender and treatment position (prone or supine), using only pretreatment imaging data. Methods: Data of 20 patients, treated for tumors in the pelvic region with the entire bladder visible on CT and CBCT, were divided into four equally sized groups based on gender and treatment position. The full and empty bladder contour, that can be acquired with pretreatment CT imaging, were used to generate a patient-specific bladder shape model. This model was used to guide the segmentation process on CBCT. To obtain the bladder segmentation, the reference bladder contour was deformed iteratively by maximizing the cross-correlation between directional grey value gradients over the reference and CBCT bladder edge. To overcome incorrect segmentations caused by CBCT image artifacts, automatic adaptations were implemented. Moreover, locally incorrect segmentations could be adapted manually. After each adapted segmentation, the bladder shape model was expanded and new shape patterns were calculated for following segmentations. All available CBCTs were used to validate the segmentation algorithm. The bladder segmentations were validated by comparison with the manual delineations and the segmentation performance was quantified using the Dice similarity coefficient (DSC), surface distance error (SDE) and SD of contour-to-contour distances. Also, bladder volumes obtained by manual delineations and segmentations were compared using a Bland-Altman error analysis. Results: The mean DSC, mean SDE, and mean SD of contour-to-contour distances between segmentations and manual delineations were 0.87, 0.27 cm and 0.22 cm (female, prone), 0.85, 0.28 cm and 0.22 cm (female, supine), 0.89, 0.21 cm and 0.17 cm (male, supine) and 0.88, 0.23 cm and 0.17 cm (male, prone), respectively. Manual local adaptations improved the segmentation

  5. Assessment of the interannual variability of agricultural yields in France using satellite data and a generic land surface model

    Science.gov (United States)

    Canal, Nicolas; Calvet, Jean-Christophe; Szczypta, Camille

    2013-04-01

    The generic ISBA-A-gs Land Surface Model (LSM) is used to simulate the interannual variability of the maximum above-ground biomass (Bagm) of cereals and grasslands in France. Agricultural statistics are used to optimize the maximal available soil water content (MaxAWC) of the model. For a number of administrative units, significant correlations between the simulated Bagm and the agricultural yield statistics are found over the 1994-2010 period. It is shown that the interannual variability of Bagm and of the simulated soil moisture correlate at given key periods. Significant correlations are found between ten-daily averaged simulated soil moisture and the simulated (observed) Bagm (yields). The corresponding plant growth stage is determined through the Leaf Area Index (LAI). Moreover, it is shown that the interannual variability of the modelled LAI and of the new satellite-derived GEOLAND2 LAI are consistent. The predictive value of both simulated and observed LAI on the agricultural yield (10 to 40 days before harvest) is investigated. The scores are used to benchmark different configurations of the model. In particular two contrasting representations of the soil moisture profile are considered: (1) one root-zone layer, (2) several soil layers with an explicit representation of diffusion processes and an exponential root density profile, with or without a deep soil layer below the root-zone.

  6. Effect of Anatomically Realistic Full-Head Model on Activation of Cortical Neurons in Subdural Cortical Stimulation—A Computational Study

    Science.gov (United States)

    Seo, Hyeon; Kim, Donghyeon; Jun, Sung Chan

    2016-06-01

    Electrical brain stimulation (EBS) is an emerging therapy for the treatment of neurological disorders, and computational modeling studies of EBS have been used to determine the optimal parameters for highly cost-effective electrotherapy. Recent notable growth in computing capability has enabled researchers to consider an anatomically realistic head model that represents the full head and complex geometry of the brain rather than the previous simplified partial head model (extruded slab) that represents only the precentral gyrus. In this work, subdural cortical stimulation (SuCS) was found to offer a better understanding of the differential activation of cortical neurons in the anatomically realistic full-head model than in the simplified partial-head models. We observed that layer 3 pyramidal neurons had comparable stimulation thresholds in both head models, while layer 5 pyramidal neurons showed a notable discrepancy between the models; in particular, layer 5 pyramidal neurons demonstrated asymmetry in the thresholds and action potential initiation sites in the anatomically realistic full-head model. Overall, the anatomically realistic full-head model may offer a better understanding of layer 5 pyramidal neuronal responses. Accordingly, the effects of using the realistic full-head model in SuCS are compelling in computational modeling studies, even though this modeling requires substantially more effort.

  7. A Mock Circulatory System Incorporating a Compliant 3D-Printed Anatomical Model to Investigate Pulmonary Hemodynamics.

    Science.gov (United States)

    Knoops, Paul G M; Biglino, Giovanni; Hughes, Alun D; Parker, Kim H; Xu, Linzhang; Schievano, Silvia; Torii, Ryo

    2017-07-01

    A realistic mock circulatory system (MCS) could be a valuable in vitro testbed to study human circulatory hemodynamics. The objective of this study was to design a MCS replicating the pulmonary arterial circulation, incorporating an anatomically representative arterial model suitable for testing clinically relevant scenarios. A second objective of the study was to ensure the system's compatibility with magnetic resonance imaging (MRI) for additional measurements. A latex pulmonary arterial model with two generations of bifurcations was manufactured starting from a 3D-printed mold reconstructed from patient data. The model was incorporated into a MCS for in vitro hydrodynamic measurements. The setup was tested under physiological pulsatile flow conditions and results were evaluated using wave intensity analysis (WIA) to investigate waves traveling in the arterial system. Increased pulmonary vascular resistance (IPVR) was simulated as an example of one pathological scenario. Flow split between right and left pulmonary artery was found to be realistic (54 and 46%, respectively). No substantial difference in pressure waveform was observed throughout the various generations of bifurcations. Based on WIA, three main waves were identified in the main pulmonary artery (MPA), that is, forward compression wave, backward compression wave, and forward expansion wave. For IPVR, a rise in mean pressure was recorded in the MPA, within the clinical range of pulmonary arterial hypertension. The feasibility of using the MCS in the MRI scanner was demonstrated with the MCS running 2 h consecutively while acquiring preliminary MRI data. This study shows the development and verification of a pulmonary MCS, including an anatomically correct, compliant latex phantom. The setup can be useful to explore a wide range of hemodynamic questions, including the development of patient- and pathology-specific models, considering the ease and low cost of producing rapid prototyping molds, and the

  8. Supersymmetry breaking and gauge mediation in models with a generic superpotential

    Energy Technology Data Exchange (ETDEWEB)

    Kitano, Ryuichiro [Theoretical Division T-2, Los Alamos National Laboratory, NM 87545 (United States); Ookouchi, Yutaka [Perimeter Institute for Theoretical Physics, ON N2L2Y5 (Canada)], E-mail: yokochi@perimeterinstitute.ca

    2009-05-04

    We present a general scheme for finding or creating a metastable vacuum in supersymmetric theories. By using the formalism, we show that there is a parameter region where a metastable vacuum exists in the Wess-Zumino model coupled to messenger fields. This model serves as a perturbative renormalizable model of direct gauge mediation.

  9. Validation of airway resistance models for predicting pressure loss through anatomically realistic conducting airway replicas of adults and children.

    Science.gov (United States)

    Borojeni, Azadeh A T; Noga, Michelle L; Martin, Andrew R; Finlay, Warren H

    2015-07-16

    This work describes in vitro measurement of the total pressure loss at varying flow rate through anatomically realistic conducting airway replicas of 10 children, 4 to 8 years old, and 5 adults. Experimental results were compared with analytical predictions made using published airway resistance models. For the adult replicas, the model proposed by van Ertbruggen et al. (2005. J. Appl. Physiol. 98, 970-980) most accurately predicted central conducting airway resistance for inspiratory flow rates ranging from 15 to 90 L/min. Models proposed by Pedley et al. (1970. J. Respir. Physiol. 9, 371-386) and by Katz et al. (2011. J. Biomech. 44, 1137-1143) also provided reasonable estimates, but with a tendency to over predict measured pressure loss for both models. For child replicas, the Pedley and Katz models both provided good estimation of measured pressure loss at flow rates representative of resting tidal breathing, but under predicted measured values at high inspiratory flow rate (60 L/min). The van Ertbruggen model, developed based on flow simulations performed in an adult airway model, tended to under predict measured pressure loss through the child replicas across the range of flow rates studied (2 to 60 L/min). These results are intended to provide guidance for selection of analytical pressure loss models for use in predicting airway resistance and ventilation distribution in adults and children. Copyright © 2015 Elsevier Ltd. All rights reserved.

  10. Evaluation of the anatomical and functional consequences of repetitive mild cervical contusion using a model of spinal concussion.

    Science.gov (United States)

    Jin, Ying; Bouyer, Julien; Haas, Christopher; Fischer, Itzhak

    2015-09-01

    Spinal cord concussion is characterized by a transient loss of motor and sensory function that generally resolves without permanent deficits. Spinal cord concussions usually occur during vehicular accidents, falls, and sport activity, but unlike brain concussions, have received much less attention despite the potential for repeated injury leading to permanent neurological sequelae. Consequently, there is no consensus regarding decisions related to return to play following an episode of spinal concussion, nor an understanding of the short- and long-term consequences of repeated injury. Importantly, there are no models of spinal concussion to study the anatomical and functional sequelae of single or repeated injury. We have developed a new model of spinal cord concussion focusing on the anatomical and behavioral outcomes of single and repeated injury. Rats received a very mild (50 kdyn, IH impactor) spinal contusion at C5 and were separated into two groups three weeks after the initial injury--C1, which received a second, sham surgery, and C2, which received a second contusion at the same site. To track motor function and recovery, animals received weekly behavioral tests--BBB, CatWalk™, cylinder, and Von Frey. Analysis of locomotor activity by BBB demonstrated that rats rapidly recovered, regaining near-normal function by one week after the first and second injury, which was confirmed using the more detailed CatWalk™ analysis. The cylinder test showed that a single contusion did not induce significant deficits of the affected limb, but that repeated injury resulted in significant alteration in paw preference, with animals favoring the unaffected limb. Intriguingly, Von Frey analysis demonstrated an increased sensitivity in the contralateral hindlimb in the C2 group vs. the C1 group. Anatomical analyses revealed that while the lesion volume of both groups was minimal, the area of spared white matter in the C2 group was significantly reduced 1 and 2mm rostral to

  11. The development of a generic ecosystem model for assessing the effects of elevated carbon dioxide on ecosystems. Progress report, September 1, 1986--May 18, 1987

    Energy Technology Data Exchange (ETDEWEB)

    Reynolds, J.F.; Skiles, J.W.; Dougherty, R.L.

    1987-05-19

    This report consists of three major sections which are: progress made on the development of a generic plant growth model, progress made on the holistic ecosystem model, and a summary outlining future directions of our modeling efforts. The major accomplishments of the plant growth modeling have been the identification and implementation of components for the photosynthesis module, development of a plant canopy module, and further refinement of the various modules that make up the basic structure for a generic plant growth mode. Research examined several implementations of a leaf-based, CO{sub 2} responsive, photosynthesis model that incorporates information at the enzyme-kinetics level. Also presented, are several models of forest canopies, transpiration, and photosynthesis.

  12. Comparison of approaches for parameter estimation on stochastic models: Generic least squares versus specialized approaches.

    Science.gov (United States)

    Zimmer, Christoph; Sahle, Sven

    2016-04-01

    Parameter estimation for models with intrinsic stochasticity poses specific challenges that do not exist for deterministic models. Therefore, specialized numerical methods for parameter estimation in stochastic models have been developed. Here, we study whether dedicated algorithms for stochastic models are indeed superior to the naive approach of applying the readily available least squares algorithm designed for deterministic models. We compare the performance of the recently developed multiple shooting for stochastic systems (MSS) method designed for parameter estimation in stochastic models, a stochastic differential equations based Bayesian approach and a chemical master equation based techniques with the least squares approach for parameter estimation in models of ordinary differential equations (ODE). As test data, 1000 realizations of the stochastic models are simulated. For each realization an estimation is performed with each method, resulting in 1000 estimates for each approach. These are compared with respect to their deviation to the true parameter and, for the genetic toggle switch, also their ability to reproduce the symmetry of the switching behavior. Results are shown for different set of parameter values of a genetic toggle switch leading to symmetric and asymmetric switching behavior as well as an immigration-death and a susceptible-infected-recovered model. This comparison shows that it is important to choose a parameter estimation technique that can treat intrinsic stochasticity and that the specific choice of this algorithm shows only minor performance differences.

  13. Using peer-assisted learning and role-playing to teach generic skills to dental students: the health care simulation model.

    Science.gov (United States)

    El Tantawi, Maha M A; Abdelaziz, Hytham; AbdelRaheem, Amira S; Mahrous, Ahmed A

    2014-01-01

    Increasing importance is attached to teaching generic skills to undergraduate students in various disciplines. This article describes an extracurricular, student-led activity for teaching generic skills using the Model United Nations over three months. The activity used the Health Care Simulation Model (HCSM) with peer learning and role-playing to accomplish its objectives. An interview was used to select from undergraduate and postgraduate dental students at Alexandria University, Alexandria, Egypt, to develop a group of staff to act as peer teachers after receiving training (n=77). These peer teachers provided training for 123 undergraduate dental students to serve as delegates who acted as trainees or peer learners. At the end of the training sessions, a conference was held in which the students played the roles of delegates representing officials responsible for health care systems in ten countries. The students reported improvement in generic skills, enjoyed several aspects of the experience, and disliked other aspects of the model to a lesser extent. In multivariate analysis, perceived usefulness of the HCSM was significantly greater for staff than delegates and increased as self-reported improvement in knowledge of health care systems increased. This study suggests that innovative, student-centered educational methods can be effective for teaching generic skills and factual information.

  14. DEBkiss or the quest for the simplest generic model of animal life history.

    Science.gov (United States)

    Jager, Tjalling; Martin, Benjamin T; Zimmer, Elke I

    2013-07-07

    Understanding the life cycle of individual animals, and how it responds to stress, requires a model that causally links life-history traits (feeding, growth, development and reproduction). Dynamic Energy Budget (DEB) theory offers a powerful and formalised framework for building process-based models for organism life cycles. However, it takes some serious investment to understand the resulting equations and to implement them into software, and a substantial amount of data to parameterise. For many practical applications, there is therefore a need for further simplification. Here, we present a simple and transparent model that fully specifies the life cycle of an (invertebrate) animal, applies a strict mass balance, and has direct access to the primary parameters that determine the metabolic processes. We derive our 'DEBkiss' in a formalised manner, starting from an explicit formulation of the simplifying assumptions. The presented model can serve as a teaching tool and a smooth introduction into the much richer world of DEB theory. Furthermore, the model may prove useful as a building block for individual-based population modelling (where simplicity of the blocks is essential), and for the analysis of toxicity data (where ease of model verification and parameterisation is crucial). The model is illustrated using a fit on growth and reproduction data for the pond snail (Lymnaea stagnalis) at three food levels, and subsequent predictions for embryonic growth and respiration (oxygen use), and weight loss on starvation, for the same species.

  15. A Generic Bio-Economic Farm Model for Environmental and Economic Assessment of Agricultural Systems

    NARCIS (Netherlands)

    Janssen, S.J.C.; Louhichi, K.; Kanellopoulos, A.; Zander, P.; Flichman, G.; Hengsdijk, H.; Meuter, E.C.; Andersen, E.; Belhouchette, H.; Blanco, M.; Borkowski, N.; Heckelei, T.; Hecker, M.; Li, Hongtao; Oude Lansink, A.G.J.M.; Stokstad, G.; Thorne, P.; Keulen, van H.; Ittersum, van M.K.

    2010-01-01

    Bio-economic farm models are tools to evaluate ex-post or to assess ex-ante the impact of policy and technology change on agriculture, economics and environment. Recently, various BEFMs have been developed, often for one purpose or location, but hardly any of these models are re-used later for other

  16. Application of the Generic Modeling Template Approach to Unsaturated Fatty Acid Oxidation and Crystallization Systems

    DEFF Research Database (Denmark)

    Fedorova, Marina; Papadakis, Emmanouil; Meisler, Kresten Troelstrup

    2014-01-01

    In this work, a couple of applications of the template-based approach for model development are presented. The computer-aided template concept has been developed based on a model decomposition technique and has been implemented as a software tool, which provides a user-friendly interface for foll...

  17. A generic concept for the development of model-guided clinical decision support systems

    Directory of Open Access Journals (Sweden)

    Denecke Kerstin

    2015-09-01

    Full Text Available Disease development and progression are very complex processes which make clinical decision making non-trivial. On the one hand, examination results that are stored in multiple formats and data types in clinical information systems need to be considered. Beyond, biological or molecular-biological processes can influence clinical decision making. So far, biological knowledge and patient data is separated from each other. This complicates inclusion of all relevant knowledge and information into the decision making. In this paper, we describe a concept of model-based decision support that links knowledge about biological processes, treatment decisions and clinical data. It consists of three models: 1 a biological model, 2 a decision model encompassing medical knowledge about the treatment workflow and decision parameters, and 3 a patient data model generated from clinical data. Requirements and future steps for realizing the concept will be presented and it will be shown how the concept can support the clinical decision making.

  18. A Generic Discrete-Event Simulation Model for Outpatient Clinics in a Large Public Hospital

    Directory of Open Access Journals (Sweden)

    Waressara Weerawat

    2013-01-01

    Full Text Available The orthopedic outpatient department (OPD ward in a large Thai public hospital is modeled using Discrete-Event Stochastic (DES simulation. Key Performance Indicators (KPIs are used to measure effects across various clinical operations during different shifts throughout the day. By considering various KPIs such as wait times to see doctors, percentage of patients who can see a doctor within a target time frame, and the time that the last patient completes their doctor consultation, bottlenecks are identified and resource-critical clinics can be prioritized. The simulation model quantifies the chronic, high patient congestion that is prevalent amongst Thai public hospitals with very high patient-to-doctor ratios. Our model can be applied across five different OPD wards by modifying the model parameters. Throughout this work, we show how DES models can be used as decision-support tools for hospital management.

  19. A generic discrete-event simulation model for outpatient clinics in a large public hospital.

    Science.gov (United States)

    Weerawat, Waressara; Pichitlamken, Juta; Subsombat, Peerapong

    2013-01-01

    The orthopedic outpatient department (OPD) ward in a large Thai public hospital is modeled using Discrete-Event Stochastic (DES) simulation. Key Performance Indicators (KPIs) are used to measure effects across various clinical operations during different shifts throughout the day. By considering various KPIs such as wait times to see doctors, percentage of patients who can see a doctor within a target time frame, and the time that the last patient completes their doctor consultation, bottlenecks are identified and resource-critical clinics can be prioritized. The simulation model quantifies the chronic, high patient congestion that is prevalent amongst Thai public hospitals with very high patient-to-doctor ratios. Our model can be applied across five different OPD wards by modifying the model parameters. Throughout this work, we show how DES models can be used as decision-support tools for hospital management.

  20. A generic conceptual and UML model for the multi-echelon distribution supply chain

    Directory of Open Access Journals (Sweden)

    Hamid Ech-Cheikh

    2012-10-01

    Full Text Available The Multi-Echelon Distribution Supply Chain (MEDSC is a multifaceted structure, focusing on the integration of all factors that involved in the overall distribution process of finished products to thecustomers. The growing interest in multi-echelon distribution systems has highlighted the need to adopt an appropriate approach to ensure the efficient management of their complexity. While there is asignificant amount of analytical research modeling the MEDSC, few studies have used simulation models for this system. The objective of the paper is to model the operational level of the MEDSC network and to obtain a real reflection of its behavior. The permanent interaction among the various components of the MEDSC and the increasing complexity of such system requires a simulation model, which is able to integrate a set of dynamic characteristics and stochastic aspects. Furthermore, this model will be adapted to several configurations of the multi-echelon network. Thus, this research has twofold: first to recall the issues regarding the flow management and inventory control in the MEDSC, then using the objectoriented approach through the Unified Modeling Language (UML to build a flexible supply chain model.

  1. A Generic 1D Forward Modeling and Inversion Algorithm for TEM Sounding with an Arbitrary Horizontal Loop

    Science.gov (United States)

    Li, Zhanhui; Huang, Qinghua; Xie, Xingbing; Tang, Xingong; Chang, Liao

    2016-08-01

    We present a generic 1D forward modeling and inversion algorithm for transient electromagnetic (TEM) data with an arbitrary horizontal transmitting loop and receivers at any depth in a layered earth. Both the Hankel and sine transforms required in the forward algorithm are calculated using the filter method. The adjoint-equation method is used to derive the formulation of data sensitivity at any depth in non-permeable media. The inversion algorithm based on this forward modeling algorithm and sensitivity formulation is developed using the Gauss-Newton iteration method combined with the Tikhonov regularization. We propose a new data-weighting method to minimize the initial model dependence that enhances the convergence stability. On a laptop with a CPU of i7-5700HQ@3.5 GHz, the inversion iteration of a 200 layered input model with a single receiver takes only 0.34 s, while it increases to only 0.53 s for the data from four receivers at a same depth. For the case of four receivers at different depths, the inversion iteration runtime increases to 1.3 s. Modeling the data with an irregular loop and an equal-area square loop indicates that the effect of the loop geometry is significant at early times and vanishes gradually along the diffusion of TEM field. For a stratified earth, inversion of data from more than one receiver is useful in noise reducing to get a more credible layered earth. However, for a resistive layer shielded below a conductive layer, increasing the number of receivers on the ground does not have significant improvement in recovering the resistive layer. Even with a down-hole TEM sounding, the shielded resistive layer cannot be recovered if all receivers are above the shielded resistive layer. However, our modeling demonstrates remarkable improvement in detecting the resistive layer with receivers in or under this layer.

  2. Heating properties of the needle type applicator made of shape memory alloy by 3-D anatomical human head model.

    Science.gov (United States)

    Mimoto, N; Kato, K; Kanazawa, Y; Shindo, Y; Tsuchiya, K; Kubo, M; Uzuka, T; Takahashi, H; Fujii, Y

    2009-01-01

    Since the human brain is protected by the skull, it is not easy to non-invasively heat deep brain tumors with electromagnetic energy for hyperthermia treatments. Generally, needle type applicators were used in clinical practice to heat brain tumors. To expand the heating area of needle type applicators, we have developed a new type of needle made of a shape memory alloy (SMA). In this paper, heating properties of the proposed SMA needle type applicator were discussed. Here, in order to apply the SMA needle type applicator clinically. First, we constructed an anatomical 3-D FEM model from MRI and X-ray CT images using 3D-CAD software. Second, we estimated electric and temperature distributions to confirm the SMA needle type applicator using the FEM soft were JMAG-Studio. From these results, it was confirmed that the proposed method can expand the heating area and control the heating of various sizes of brain tumors.

  3. A Generic Quality Assurance Model (GQAM) for successful e-health implementation in rural hospitals in South Africa.

    Science.gov (United States)

    Ruxwana, Nkqubela; Herselman, Marlien; Pottas, Dalenca

    2014-01-01

    Although e-health can potentially facilitate the management of scarce resources and improve the quality of healthcare services, implementation of e-health programs continues to fail or not fulfil expectations. A key contributor to the failure of e-health implementation in rural hospitals is poor quality management of projects. Based on a survey 35 participants from five rural hospitals in the Eastern Cape Province of South Africa, and using a qualitative case study research methodology, this article attempted to answer the question: does the adoption of quality assurance (QA) models add value and help to ensure success of information technology projects, especially in rural health settings? The study identified several weaknesses in the application of QA in these hospitals; however, findings also showed that the QA methods used, in spite of not being formally applied in a standardised manner, did nonetheless contribute to the success of some projects. The authors outline a generic quality assurance model (GQAM), developed to enhance the potential for successful acquisition of e-health solutions in rural hospitals, in order to improve the quality of care and service delivery in these hospitals.

  4. Generic process model structures: towards a standard notation for abstract representations

    CSIR Research Space (South Africa)

    Van Der Merwe, A

    2007-10-01

    Full Text Available The identification of process model structures is usually complex and costly. If these structures can be reused across boundaries, this could not only benefit the internal structure of one application domain, but could also benefit organizations...

  5. Generic Architecture for Cloud Infrastructure as a Service (IaaS) Provisioning Model

    NARCIS (Netherlands)

    Demchenko, Y.; Ham, J. van der; Strijkers, R.J.; Ghijsen, M.; Ngo, C.; Cristea, M.

    2011-01-01

    This document provides information about the proposed architectural framework for Cloud Infrastructure as a Service (IaaS) provisioning model that includes the following components: the Composable Services Architecture (CSA) that intends to provide a conceptual and methodological framework for

  6. Towards a generic, reliable CFD modelling methodology for waste-fired grate boilers

    DEFF Research Database (Denmark)

    Rajh, Boštjan; Yin, Chungen; Samec, Niko

    Computational Fluid Dynamics (CFD) is increasingly used in industry for detailed understanding of the combustion process and for appropriate design and optimization of Waste–to–Energy (WtE) plants. In this paper, CFD modelling of waste wood combustion in a 13 MW grate-fired boiler in a WtE plant...... the appropriate inlet boundary condition for the freeboard 3D CFD simulation. Additionally, a refined WSGGM (weighted sum of gray gases model) of greater accuracy, completeness and applicability is proposed and implemented into the CFD model via user defined functions (UDF) to better address the impacts...... is presented. To reduce the risk of slagging, optimize the temperature control and enhance turbulent mixing, part of the flue gas is recycled into the grate boiler. In the simulation, a 1D in–house bed model is developed to simulate the conversion of the waste wood in the fuel bed on the grate, which provides...

  7. A Generic Decomposition Formula for Pricing Vanilla Options under Stochastic Volatility Models

    Directory of Open Access Journals (Sweden)

    Raúl Merino

    2015-01-01

    Full Text Available We obtain a decomposition of the call option price for a very general stochastic volatility diffusion model, extending a previous decomposition formula for the Heston model. We realize that a new term arises when the stock price does not follow an exponential model. The techniques used for this purpose are nonanticipative. In particular, we also see that equivalent results can be obtained by using Functional Itô Calculus. Using the same generalizing ideas, we also extend to nonexponential models the alternative call option price decomposition formula written in terms of the Malliavin derivative of the volatility process. Finally, we give a general expression for the derivative of the implied volatility under both the anticipative and the nonanticipative cases.

  8. Evolutionary ecology in silico: Does mathematical modelling help in understanding `generic' trends?

    Indian Academy of Sciences (India)

    Debashish Chowdhury; Dietrich Stauffer

    2005-03-01

    Motivated by the results of recent laboratory experiments, as well as many earlier field observations, that evolutionary changes can take place in ecosystems over relatively short ecological time scales, several ‘unified’ mathematical models of evolutionary ecology have been developed over the last few years with the aim of describing the statistical properties of data related to the evolution of ecosystems. Moreover, because of the availability of sufficiently fast computers, it has become possible to carry out detailed computer simulations of these models. For the sake of completeness and to put these recent developments in perspective, we begin with a brief summary of some older models of ecological phenomena and evolutionary processes. However, the main aim of this article is to review critically these ‘unified’ models, particularly those published in the physics literature, in simple language that makes the new theories accessible to a wider audience.

  9. Generic Combined Heat and Power (CHP Model for the Concept Phase of Energy Planning Process

    Directory of Open Access Journals (Sweden)

    Satya Gopisetty

    2016-12-01

    Full Text Available Micro gas turbines (MGTs are regarded as combined heat and power (CHP units which offer high fuel utilization and low emissions. They are applied in decentralized energy generation. To facilitate the planning process of energy systems, namely in the context of the increasing application of optimization techniques, there is a need for easy-to-parametrize component models with sufficient accuracy which allow a fast computation. In this paper, a model is proposed where the non-linear part load characteristics of the MGT are linearized by means of physical insight of the working principles of turbomachinery. Further, it is shown that the model can be parametrized by the data usually available in spec sheets. With this model a uniform description of MGTs from several manufacturers covering an electrical power range from 30 k W to 333 k W can be obtained. The MGT model was implemented by means of Modelica/Dymola. The resulting MGT system model, comprising further heat exchangers and hydraulic components, was validated using the experimental data of a 65 k W MGT from a trigeneration energy system.

  10. Transformation models for effective friction angle and relative density calibrated based on generic database of coarse-grained soils

    National Research Council Canada - National Science Library

    Lin, Guan-Hong; Chen, Jie-Ru; Ching, Jianye; Phoon, Kok-Kwang

    2017-01-01

    This study compiles a generic database of seven parameters, including relative density and friction angle, for coarse-grained soils from 176 studies, covering a wide range of reconstituted and in situ...

  11. CLM4-BeTR, a generic biogeochemical transport and reaction module for CLM4: model development, evaluation, and application

    Directory of Open Access Journals (Sweden)

    J. Tang

    2012-09-01

    Full Text Available To improve regional and global biogeochemistry modeling and climate predictability, we have developed a generic reactive transport module for the land model CLM4 (called CLM4-BeTR (Biogeochemical Transport and Reactions. CLM4-BeTR represents the transport, interactions, and biotic and abiotic transformations of an arbitrary number of tracers (aka chemical species in an arbitrary number of phases (e.g. dissolved, gaseous, sorbed, aggregate. An operator splitting approach was employed and consistent boundary conditions were derived for each modeled sub-process. Tracer fluxes, associated with hydrological processes such as surface run-on and run-off, belowground drainage, and ice to liquid conversion were also computed consistently with the bulk water fluxes calculated by the soil physics module in CLM4. The transport code was evaluated and found be in good agreement with several analytical test cases. The model was then applied at the Harvard Forest site with a representation of depth-dependent belowground biogeochemistry. The results indicated that, at this site, (1 CLM4-BeTR was able to simulate soil-surface CO2 effluxes and soil CO2 profiles accurately; (2 the transient surface CO2 effluxes calculated based on the tracer transport mechanism were in general not equal to the belowground CO2 production rates and that their differences varied according to the seasonal cycle of soil physics and biogeochemistry; (3 losses of CO2 through processes other than surface gas efflux were less than 1% of the overall soil respiration; and (4 the contributions of root respiration and heterotrophic respiration have distinct temporal signals in surface CO2 effluxes and soil CO2 concentrations. The development of CLM4-BeTR will allow detailed comparisons between ecosystem observations and predictions and insights to the modeling of terrestrial biogeochemistry.

  12. Development of a Generic Performance Measurement Model in an Emergency Department

    DEFF Research Database (Denmark)

    Sørup, Christian Michel; Lundager Forberg, Jakob

    performance measures that provide an estimate for overall ED performance levels. Furthermore, a thorough analysis of the interdependencies between the included performance measures was conducted in order to gain deeper knowledge of the ED as a system. The model enables monitoring of how well the ED performs......Fewer and larger hospitals are expected in the forthcoming years due to the latest and on-going structural changes in the Danish healthcare sector. These large hospitals must be able to handle an increasing flow of patients, thus creating challenges for both logistics and resources. In connection......, and the use of triage. All of the mentioned initiatives are new and not well validated to date. It would be desirable to enable measurement of each of the initiative’s effects. The goal of this PhD project was to develop a performance measurement model for EDs. The new model comprises only the most important...

  13. A Scalable Model for the Performance Evaluation of ROADMs with Generic Switching Capabilities

    Directory of Open Access Journals (Sweden)

    Athanasios S Tsokanos

    2010-10-01

    Full Text Available In order to evaluate the performance of Reconfigurable Optical Add/Drop Multiplexers (ROADMs consisting of a single large switch, in circuit switched Wavelength-Division Multiplexing (WDM networks, a theoretical Queuing Network Model (QNM is developed, which consists of two M/M/c/c loss systems each of which is analyzed in isolation. An overall analytical blocking probability of a ROADM is obtained. This model can also be used for the performance optimization of ROADMs with a single switch capable of switching all or a partial number of the wavelengths being used. It is demonstrated how the proposed model can be used for the performance evaluation of a ROADM for different number of wavelengths inside the switch, in various traffic intensity conditions producing an exact blocking probability solution. The accuracy of the analytical results is validated by simulation.

  14. A Generic Minimal Discrete Model for Toroidal Moments and Its Experimental Realization

    CERN Document Server

    Xiang, Hong; Liu, Liang; Jiang, Tianshu; Zhang, Z Q; Chan, C T; Han, Dezhuan

    2016-01-01

    It is well known that a closed loop of magnetic dipoles can give rise to the rather elusive toroidal moment. However, artificial structures required to generate the necessary magnetic moments are typically optically large, complex to make and easily compromised by the kinetic inductance at high frequencies. Instead of using magnetic dipoles, we propose a minimal model based on just three aligned discrete electric dipoles in which the occurrence of resonant toroidal modes is guaranteed by symmetry. The advantage of this model is its simplicity and the same model supports toroidal moments from the microwave regime up to optical frequencies as exemplified by a three-antenna array and a system consisting of three nano-sized plasmonic particles. Both the microwave and high-frequency configurations exhibit non-radiating "anapoles". Experiments in the microwave regime confirm the theoretical predictions.

  15. Generic Model-Based Tailor-Made Design and Analysis of Biphasic Reaction Systems

    DEFF Research Database (Denmark)

    Anantpinijwatna, Amata

    contribution of this thesis is the development of a systematic modelling framework for the biphasic reaction system. The developed framework consists of three modules describing phase equilibria, reactions and mass transfer, and material balances of such processes. Correlative and predictive thermodynamic......-elementary reaction rate laws. Extents of reaction are used to calculate the species material balances. The resulting mathematical model contains temperature dependent reaction rate parameters,equilibrium constants, and partition coefficients; where only the reaction rates are to be regressed to a minimum of time...

  16. Phase I Experimental Testing of a Generic Submarine Model in the DSTO Low Speed Wind Tunnel

    Science.gov (United States)

    2012-07-01

    force (N) M Moment about the z-axis (Nm) MRP Moment Reference Point N Moment about the y-axis (Nm) q Dynamic pressure       2 2 1 U (Pa... MRP ) is defined as the mid-length position on the centre-line of the model, and the strain gauge balance reference centre is located 77.64 mm...axially forward, and 28.0 mm vertically above the model MRP . 1350 m m 675 m m Stra in Gauge Balance 28.0m m M om ent Reference Point (M RP) 77.64m m

  17. A generic biokinetic model for noble gases with application to radon

    Energy Technology Data Exchange (ETDEWEB)

    Leggett, Richard Wayne [ORNL; Marsh, James [Health Protection Agency of Great Britain; Gregoratto, Demetrio [Health Protection Agency of Great Britain; Blanchardon, Eric [IRSN

    2013-01-01

    The International Commission for Radiological Protection (ICRP) currently uses a dose conversion coefficient to calculate effective dose per unit exposure to radon and its progeny. The coefficient is derived by dividing the detriment associated with unit exposure to radon, as estimated from epidemiological studies, by the detriment per unit effective dose, as estimated mainly from atomic bomb survivor data and animal studies. In a recent statement the ICRP indicated that future guidance on exposure to radon and its progeny will be developed in the same way as guidance for any other radionuclide. That is, intake of radon and progeny will be limited on the basis of effective dose coefficients derived from biokinetic and dosimetric models. This paper proposes a biokinetic model for systemic (absorbed) radon for use in the calculation of dose coefficients for inhaled or ingested radon. The model is based largely on physical laws governing transfer of a non-reactive and soluble gas between materials. Model predictions are shown to be consistent with results of controlled studies of the fate of internally deposited radon in human subjects.

  18. Modelling and mapping spread in pest risk analysis: a generic approach

    NARCIS (Netherlands)

    Kehlenbeck, H.; Robinet, C.; Werf, van der W.; Kriticos, D.; Reynaud, P.; Baker, R.

    2012-01-01

    Assessing the likelihood and magnitude of spread is one of the cornerstones of pest risk analysis (PRA), and is usually based on qualitative expert judgment. This paper proposes a suite of simple ecological models to support risk assessors who also wish to estimate the rate and extent of spread, e.g

  19. The relevance of non-generic events in scale space models

    NARCIS (Netherlands)

    Kuijper, Arjan; Florack, L.

    2002-01-01

    In order to investigate the deep structure of Gaussian scale space images, one needs to understand the behaviour of spatial critical points under the influence of blurring. We show how the mathematical framework of catastrophe theory can be used to describe and model the behaviour of critical point

  20. Generic Architecture for Cloud Infrastructure as a Service (IaaS) Provisioning Model

    NARCIS (Netherlands)

    Demchenko, Y.; Ham, J. van der; Strijkers, R.J.; Ghijsen, M.; Ngo, C.; Cristea, M.

    2011-01-01

    This document provides information about the proposed architectural framework for Cloud Infrastructure as a Service (IaaS) provisioning model that includes the following components: the Composable Services Architecture (CSA) that intends to provide a conceptual and methodological framework for devel

  1. Lagrangian and Eulerian biventricular strains from anatomical NURBS models using tagged MRI

    Science.gov (United States)

    Tustison, Nicholas J.; Amini, Amir A.

    2005-04-01

    We present current research in which both left and right ventricular deformation is estimated from tagged cardiac magnetic resonance imaging using volumetric deformable models constructed from nonuniform rational B-splines (NURBS). The four model types considered include Cartesian-based NURBS models with both a cylindrical and prolate-spheroidal parameterization, prolate spheroidal-based NURBS models with a prolate-spheroidal parameterization, and cylindrical-based NURBS models with a cylindrical parameterization. For each frame subsequent to end-diastole, a NURBS model is constructed by fitting two surfaces with the same parameterization to the corresponding set of epicardial and endocardial contours from which a volumetric model is created. Using normal displacements of the three sets of orthogonal tag planes as well as displacements of contour/tag line intersection points and tag plane intersection points, one can solve for the optimal homogeneous coordinates, in a weighted least squares sense, of the control points of the deformed NURBS model at end-diastole using quadratic programming. This allows for subsequent forward displacement fitting from end-diastole to all later time frames. After fitting to all time points of data, lofting the NURBS model at each time point creates a comprehensive 4-D NURBS model. From this model, we can extract 3-D myocardial deformation fields and corresponding strain maps which are local measures of non-rigid deformation. The results show that, in the case of simulated data, the quadratic Cartesian-based NURBS model outperformed its counterparts in predicting normal strain. This model was used to then calculate normal Lagrangian and Eulerian strains in canine data.

  2. A dynamic and generic cloud computing model for glaciological image processing

    Science.gov (United States)

    Ranisavljević, Élisabeth; Devin, Florent; Laffly, Dominique; Le Nir, Yannick

    2014-04-01

    As satellite imaging is quite expensive, and because of poor weather conditions including common heavy cloud cover at polar latitudes, daily satellite imaging is not always accessible or suitable to observe fast temporal evolutions. We complement satellite imagery with a set of ground based autonomous automated digital cameras which take three pictures a day. With these pictures we build a mosaic with their projection and apply a classification to define the temporal evolution of the snow cover. As the pictures are subject to heavy disturbance, some processing is needed to build the mosaic. Once the processes are defined, we present our model. This model is built upon a cloud computing environment using Web services workflow. Then we present how the processes are dynamically organized using a scheduler. This scheduler chooses the order and the processes to apply to every picture to build the mosaic. Once we obtain a mosaic we can study the variation of the snow cover.

  3. A Generic Modeling Approach to Biomass Dynamics of Sagittaria latifolia and Spartina alterniflora

    Science.gov (United States)

    2011-01-01

    years. In general, variation in environmental factors such as water depth, temperature, clarity, current, wave action, and substrate characteristics... phenological cycle of the community. The ERDC TN-SWWRP-11-1 January 2011 4 dry weights (DW) of the plant organs are obtained by integration of their...ANSI Standard FORTRAN F77. Central Features. Central features of the model are the (1) link between the species-charac- teristic phenological cycle

  4. Efficient and Generic Construction of Certification-Based Encryption in the Standard Model Based on the NIZK Proof System

    Directory of Open Access Journals (Sweden)

    Yang Lu

    2012-02-01

    Full Text Available Certificate-based encryption (CBE is a new public key encryption paradigm which combines traditional PKI-based public-key encryption (PKE and identity-based encryption (IBE, and preserves some of their most attractive features. CBE provides an efficient implicit certificate mechanism and allows a periodical update of certificate status. It eliminates third-party queries for the certificate status and simplifies the certificate revocation problem in the traditional PKI, while it solves the key escrow problem and the key distribution problem inherent in IBE. In this paper, we propose a new generic construction of CBE schemes from PKE and IBE, and prove it to be CCA-secure in the standard model. In our construction, we use an efficient one-time simulation-sound adaptive NIZK proof system as the security enhancing building block to guarantee the CCA-security of the generated CBE schemes. When compared to the previous method, the security requirements of the primitive encryption schemes in our construction are much weaker and the performance of the generated CBE schemes from our construction is much more efficient.

  5. Generic models of deep formation water calculated with PHREEQC using the "gebo"-database

    Science.gov (United States)

    Bozau, E.; van Berk, W.

    2012-04-01

    To identify processes during the use of formation waters for geothermal energy production an extended hydrogeochemical thermodynamic database (named "gebo"-database) for the well known and commonly used software PHREEQC has been developed by collecting and inserting data from literature. The following solution master species: Fe(+2), Fe(+3), S(-2), C(-4), Si, Zn, Pb, and Al are added to the database "pitzer.dat" which is provided with the code PHREEQC. According to the solution master species the necessary solution species and phases (solid phases and gases) are implemented. Furthermore, temperature and pressure adaptations of the mass action law constants, Pitzer parameters for the calculation of activity coefficients in waters of high ionic strength and solubility equilibria among gaseous and aqueous species of CO2, methane, and hydrogen sulphide are implemented into the "gebo"-database. Combined with the "gebo"-database the code PHREEQC can be used to test the behaviour of highly concentrated solutions (e.g. formation waters, brines). Chemical changes caused by temperature and pressure gradients as well as the exposure of the water to the atmosphere and technical equipments can be modelled. To check the plausibility of additional and adapted data/parameters experimental solubility data from literature (e.g. sulfate and carbonate minerals) are compared to modelled mineral solubilities at elevated levels of Total Dissolved Solids (TDS), temperature, and pressure. First results show good matches between modelled and experimental mineral solubility for barite, celestite, anhydrite, and calcite in high TDS waters indicating the plausibility of additional and adapted data and parameters. Furthermore, chemical parameters of geothermal wells in the North German Basin are used to test the "gebo"-database. The analysed water composition (starting with the main cations and anions) is calculated by thermodynamic equilibrium reactions of pure water with the minerals found in

  6. Anatomically accurate high resolution modeling of human whole heart electromechanics: A strongly scalable algebraic multigrid solver method for nonlinear deformation

    Science.gov (United States)

    Augustin, Christoph M.; Neic, Aurel; Liebmann, Manfred; Prassl, Anton J.; Niederer, Steven A.; Haase, Gundolf; Plank, Gernot

    2016-01-01

    Electromechanical (EM) models of the heart have been used successfully to study fundamental mechanisms underlying a heart beat in health and disease. However, in all modeling studies reported so far numerous simplifications were made in terms of representing biophysical details of cellular function and its heterogeneity, gross anatomy and tissue microstructure, as well as the bidirectional coupling between electrophysiology (EP) and tissue distension. One limiting factor is the employed spatial discretization methods which are not sufficiently flexible to accommodate complex geometries or resolve heterogeneities, but, even more importantly, the limited efficiency of the prevailing solver techniques which is not sufficiently scalable to deal with the incurring increase in degrees of freedom (DOF) when modeling cardiac electromechanics at high spatio-temporal resolution. This study reports on the development of a novel methodology for solving the nonlinear equation of finite elasticity using human whole organ models of cardiac electromechanics, discretized at a high para-cellular resolution. Three patient-specific, anatomically accurate, whole heart EM models were reconstructed from magnetic resonance (MR) scans at resolutions of 220 μm, 440 μm and 880 μm, yielding meshes of approximately 184.6, 24.4 and 3.7 million tetrahedral elements and 95.9, 13.2 and 2.1 million displacement DOF, respectively. The same mesh was used for discretizing the governing equations of both electrophysiology (EP) and nonlinear elasticity. A novel algebraic multigrid (AMG) preconditioner for an iterative Krylov solver was developed to deal with the resulting computational load. The AMG preconditioner was designed under the primary objective of achieving favorable strong scaling characteristics for both setup and solution runtimes, as this is key for exploiting current high performance computing hardware. Benchmark results using the 220 μm, 440 μm and 880 μm meshes demonstrate

  7. The diffusion of generics after patent expiry in Germany.

    Science.gov (United States)

    Fischer, Katharina Elisabeth; Stargardt, Tom

    2016-11-01

    To identify the influences on the diffusion of generics after patent expiry, we analyzed 65 generic entries using prescription data of a large German sickness fund between 2007 and 2012 in a sales model. According to theory, several elements are responsible for technology diffusion: (1) time reflecting the rate of adaption within the social system, (2) communication channels, and (3) the degree of incremental innovation, e.g., the modifications of existing active ingredient's strength. We investigated diffusion in two ways: (1) generic market share (percentage of generic prescriptions of all prescriptions of a substance) and, (2) generic sales quantity (number of units sold) over time. We specified mixed regression models. Generic diffusion takes considerable time. An average generic market share of about 75 % was achieved not until 48 months. There was a positive effect of time since generic entry on generic market share (p innovation influenced generic market share (mostly p < 0.001), but not generic sales quantity. Market structure, e.g., the number of generic manufacturers (p < 0.001) and prices influenced both generic market share and sales. Imperfections in generic uptake through informational cascades seem to be largely present. Third-party payers could enhance means to promote generic diffusion to amplify savings through generic entry.

  8. A generic model for spoilage of acidic emulsified foods: combining physicochemical data, diversity and levels of specific spoilage organisms.

    Science.gov (United States)

    Manios, Stavros G; Lambert, Ronald J W; Skandamis, Panagiotis N

    2014-01-17

    The spoilage pattern of three emulsified, vegetable-based spreads of low pH (3.90-4.15) adjusted with acetic acid was characterized by correlating the growth of spoilage flora with the organoleptic and physicochemical changes, as well as the changes in the species composition of the dominant microflora during storage under isothermal conditions. In a further step, a generic (hereafter called 'unified') model was developed to describe the maximum specific growth rate of the specific spoilage organisms (SSOs) in all acetic acid acidified products, including literature data and additional in-house data from similar products, as a function of the storage temperature, pH (3.61-4.25) and initial concentration of the undissociated acetic acid in each product. The predictions of the unified model were compared with those of product-specific models, with temperature as the sole predictor variable. Two independent batches of commercially prepared pepper- (PS), fava beans- (FS) and eggplant-based (ES) spreads were stored at 4, 7, 10, 12, 15, 18, 20 and 25°C. The growth of lactic acid bacteria (SSOs; LAB) was correlated with changes in pH, titratable acidity and organic acids concentration, as well as sensory characteristics, in order to define the shelf-life of the products. Isolates from each spread and storage temperature were grouped with SDS-PAGE and were identified with 16S rRNA, determining the association between spoilage and species diversity. Product-specific models were developed using the square root model, while a polynomial and the Ratkowsky model were used for the development of the unified model. Products with lower pH and/or higher acetic acid content showed higher microbial stability. Lactobacillus plantarum or Lactobacillus brevis dominated the LAB association in all three spreads, although their relative percentage at the beginning of storage varied significantly. These facultative or obligate hetero-fermentative bacteria increased lactic acid and

  9. Evaluation of biofidelity of THUMS pedestrian model under a whole-body impact conditions with a generic sedan buck.

    Science.gov (United States)

    Wu, Taotao; Kim, Taewung; Bollapragada, Varun; Poulard, David; Chen, Huipeng; Panzer, Matthew B; Forman, Jason L; Crandall, Jeff R; Pipkorn, Bengt

    2017-05-29

    The goal of this study was to evaluate the biofidelity of the Total Human Model for Safety (THUMS; Ver. 4.01) pedestrian finite element models (PFEM) in a whole-body pedestrian impact condition using a well-characterized generic pedestrian buck model. The biofidelity of THUMS PFEM was evaluated with respect to data from 3 full-scale postmortem human subject (PMHS) pedestrian impact tests, in which a pedestrian buck laterally struck the subjects using a pedestrian buck at 40 km/h. The pedestrian model was scaled to match the anthropometry of the target subjects and then positioned to match the pre-impact postures of the target subjects based on the 3-dimensional motion tracking data obtained during the experiments. An objective rating method was employed to quantitatively evaluate the correlation between the responses of the models and the PMHS. Injuries in the models were predicted both probabilistically and deterministically using empirical injury risk functions and strain measures, respectively, and compared with those of the target PMHS. In general, the model exhibited biofidelic kinematic responses (in the Y-Z plane) regarding trajectories (International Organization for Standardization [ISO] ratings: Y = 0.90 ± 0.11, Z = 0.89 ± 0.09), linear resultant velocities (ISO ratings: 0.83 ± 0.07), accelerations (ISO ratings: Y = 0.58 ± 0.11, Z = 0.52 ± 0.12), and angular velocities (ISO ratings: X = 0.48 ± 0.13) but exhibited stiffer leg responses and delayed head responses compared to those of the PMHS. This indicates potential biofidelity issues with the PFEM for regions below the knee and in the neck. The model also demonstrated comparable reaction forces at the buck front-end regions to those from the PMHS tests. The PFEM generally predicted the injuries that the PMHS sustained but overestimated injuries in the ankle and leg regions. Based on the data considered, the THUMS PFEM was considered to be biofidelic for this pedestrian impact condition and vehicle

  10. A Generic Model for Relative Adjustment Between Optical Sensors Using Rigorous Orbit Mechanics

    Directory of Open Access Journals (Sweden)

    B. Islam

    2008-06-01

    Full Text Available The classical calibration or space resection is the fundamental task in photogrammetry. The lack of sufficient knowledge of interior and exterior orientation parameters lead to unreliable results in the photogrammetric process. One of the earliest in approaches using in photogrammetry was the plumb line calibration method. This method is suitable to recover the radial and decentering lens distortion coefficients, while the remaining interior(focal length and principal point coordinates and exterior orientation parameters have to be determined by a complimentary method. As the lens distortion remains very less it not considered as the interior orientation parameters, in the present rigorous sensor model. There are several other available methods based on the photogrammetric collinearity equations, which consider the determination of exterior orientation parameters, with no mention to the simultaneous determination of inner orientation parameters. Normal space resection methods solve the problem using control points, whose coordinates are known both in image and object reference systems. The non-linearity of the model and the problems, in point location in digital images and identifying the maximum GPS measured control points are the main drawbacks of the classical approaches. This paper addresses mathematical model based on the fundamental assumption of collineariy of three points of two Along-Track Stereo imagery sensors and independent object point. Assuming this condition it is possible to extract the exterior orientation (EO parameters for a long strip and single image together, without and with using the control points. Moreover, after extracting the EO parameters the accuracy for satellite data products are compared in with using single and with no control points.

  11. Global warming factors modelled for 40 generic municipal waste management scenarios

    DEFF Research Database (Denmark)

    Christensen, Thomas Højlund; Simion, F.; Tonini, Davide

    2009-01-01

    Global warming factors (kg CO2-eq.-tonne—1 of waste) have been modelled for 40 different municipal waste management scenarios involving a variety of recycling systems (paper, glass, plastic and organics) and residual waste management by landfilling, incineration or mechanical—biological waste...... treatment. For average European waste composition most waste management scenarios provided negative global warming factors and hence overall savings in greenhouse gas emissions: Scenarios with landfilling saved 0—400, scenarios with incineration saved 200—700, and scenarios with mechanical...

  12. Anatomical Knowledge Gain through a Clay-Modeling Exercise Compared to Live and Video Observations

    Science.gov (United States)

    Kooloos, Jan G. M.; Schepens-Franke, Annelieke N.; Bergman, Esther M.; Donders, Rogier A. R. T.; Vorstenbosch, Marc A. T. M.

    2014-01-01

    Clay modeling is increasingly used as a teaching method other than dissection. The haptic experience during clay modeling is supposed to correspond to the learning effect of manipulations during exercises in the dissection room involving tissues and organs. We questioned this assumption in two pretest-post-test experiments. In these experiments,…

  13. Anatomical knowledge gain through a clay-modeling exercise compared to live and video observations

    NARCIS (Netherlands)

    Kooloos, J.G.M.; Schepens-Franke, A.N.; Bergman, E.M.; Donders, R.; Vorstenbosch, M.A.

    2014-01-01

    Clay modeling is increasingly used as a teaching method other than dissection. The haptic experience during clay modeling is supposed to correspond to the learning effect of manipulations during exercises in the dissection room involving tissues and organs. We questioned this assumption in two prete

  14. Single-step stereolithography of complex anatomical models for optical flow measurements.

    Science.gov (United States)

    de Zélicourt, Diane; Pekkan, Kerem; Kitajima, Hiroumi; Frakes, David; Yoganathan, Ajit P

    2005-02-01

    Transparent stereolithographic rapid prototyping (RP) technology has already demonstrated in literature to be a practical model construction tool for optical flow measurements such as digital particle image velocimetry (DPIV), laser doppler velocimetry (LDV), and flow visualization. Here, we employ recently available transparent RP resins and eliminate time-consuming casting and chemical curing steps from the traditional approach. This note details our methodology with relevant material properties and highlights its advantages. Stereolithographic model printing with our procedure is now a direct single-step process, enabling faster geometric replication of complex computational fluid dynamics (CFD) models for exact experimental validation studies. This methodology is specifically applied to the in vitro flow modeling of patient-specific total cavopulmonary connection (TCPC) morphologies. The effect of RP machining grooves, surface quality, and hydrodynamic performance measurements as compared with the smooth glass models are also quantified.

  15. Development and Validation of a High Anatomical Fidelity FE Model for the Buttock and Thigh of a Seated Individual.

    Science.gov (United States)

    Al-Dirini, Rami M A; Reed, Matthew P; Hu, Jingwen; Thewlis, Dominic

    2016-09-01

    Current practices for designing new cushions for seats depend on superficial measurements, such as pressure mapping, which do not provide sufficient information about the condition of sub-dermal tissues. Finite element (FE) modelling offers a unique alternative to integrate assessment of sub-dermal tissue condition into seat/cushion design and development processes. However, the development and validation of such FE models for seated humans requires accurate representation of the anatomy and material properties, which remain challenges that are yet to be addressed. This paper presents the development and validation of a detailed 3D FE model with high anatomical fidelity of the buttock and thigh, for a specific seated subject. The developed model consisted of 28 muscles, the pelvis, sacrum, femur, and one layer of inter-muscular fat, subcutaneous fat and skin. Validation against in vivo measurements from MRI data confirmed that the FE model can simulate the deformation of soft tissues under sitting loads with an accuracy of (mean ± SD) 4.7 ± 4.4 mm. Simulation results showed that the maximum strains (compressive, shear and von-Mises) on muscles (41, 110, 79%) were higher than fat tissues (21, 62, 41%). The muscles that experienced the highest mechanical loads were the gluteus maximus, adductor magnus and muscles in the posterior aspect of the thighs (biceps femoris, semitendinosus and semimembranosus muscles). The developed FE model contributes to the progression towards bio-fidelity in modelling the human body in seated postures by providing insight into the distribution of stresses/strains in individual muscles and inter-muscular fat in the buttock and thigh of seated individuals. Industrial applications for the developed FE model include improving the design of office and household furniture, automotive and airplane seats and wheelchairs as well as customisation and assessment of sporting and medical equipment to meet individual requirements.

  16. Identification of candidate categories of the International Classification of Functioning Disability and Health (ICF for a Generic ICF Core Set based on regression modelling

    Directory of Open Access Journals (Sweden)

    Üstün Bedirhan T

    2006-07-01

    Full Text Available Abstract Background The International Classification of Functioning, Disability and Health (ICF is the framework developed by WHO to describe functioning and disability at both the individual and population levels. While condition-specific ICF Core Sets are useful, a Generic ICF Core Set is needed to describe and compare problems in functioning across health conditions. Methods The aims of the multi-centre, cross-sectional study presented here were: a to propose a method to select ICF categories when a large amount of ICF-based data have to be handled, and b to identify candidate ICF categories for a Generic ICF Core Set by examining their explanatory power in relation to item one of the SF-36. The data were collected from 1039 patients using the ICF checklist, the SF-36 and a Comorbidity Questionnaire. ICF categories to be entered in an initial regression model were selected following systematic steps in accordance with the ICF structure. Based on an initial regression model, additional models were designed by systematically substituting the ICF categories included in it with ICF categories with which they were highly correlated. Results Fourteen different regression models were performed. The variance the performed models account for ranged from 22.27% to 24.0%. The ICF category that explained the highest amount of variance in all the models was sensation of pain. In total, thirteen candidate ICF categories for a Generic ICF Core Set were proposed. Conclusion The selection strategy based on the ICF structure and the examination of the best possible alternative models does not provide a final answer about which ICF categories must be considered, but leads to a selection of suitable candidates which needs further consideration and comparison with the results of other selection strategies in developing a Generic ICF Core Set.

  17. Alternating lags of QPO harmonics: A generic model and its application to the 67 mHz QPO of GRS 1915+105

    Energy Technology Data Exchange (ETDEWEB)

    Misra, Ranjeev [Inter-University Center for Astronomy and Astrophysics, Post Bag 4, Ganeshkhind, Pune-411007 (India); Mandal, Soma, E-mail: rmisra@iucaa.ernet.in, E-mail: soma@iucaa.ernet.in [Department of Physics, Taki Government College, Taki, North 24 Parganas-743429, West Bengal (India)

    2013-12-10

    A generic model for alternating lags in quasi-periodic oscillation (QPO) harmonics is presented where variations in the photon spectrum are caused by oscillations in two parameters that characterize the spectrum. It is further assumed that variations in one of the parameters are linearly driven by variations in the other after a time delay t{sub d} . It is shown that alternating lags will be observed for a range of t{sub d} values. A phenomenological model based on this generic one is developed that can explain the amplitude and phase lag variation with energy of the fundamental and the next three harmonics of the 67 mHz QPO observed in GRS 1915+105. The phenomenological model also predicts the variation of the Bicoherence phase with energy, which can be checked by further analysis of the observational data.

  18. Influence of anatomical dominance and hypertension on coronary conduit arterial and microcirculatory flow patterns: a multiscale modeling study.

    Science.gov (United States)

    Mynard, Jonathan P; Smolich, Joseph J

    2016-07-01

    Coronary hemodynamics are known to be affected by intravascular and extravascular factors that vary regionally and transmurally between the perfusion territories of left and right coronary arteries. However, despite clinical evidence that left coronary arterial dominance portends greater cardiovascular risk, relatively little is known about the effects of left or right dominance on regional conduit arterial and microcirculatory blood flow patterns, particularly in the presence of systemic or pulmonary hypertension. We addressed this issue using a multiscale numerical model of the human coronary circulation situated in a closed-loop cardiovascular model. The coronary model represented left or right dominant anatomies and accounted for transmural and regional differences in vascular properties and extravascular compression. Regional coronary flow dynamics of the two anatomical variants were compared under normotensive conditions, raised systemic or pulmonary pressures with maintained flow demand, and after accounting for adaptations known to occur in acute and chronic hypertensive states. Key findings were that 1) right coronary arterial flow patterns were strongly influenced by dominance and systemic/pulmonary hypertension; 2) dominance had minor effects on left coronary arterial and all microvascular flow patterns (aside from mean circumflex flow); 3) although systemic hypertension favorably increased perfusion pressure, this benefit varied regionally and transmurally and was offset by increased left ventricular and septal flow demands; and 4) pulmonary hypertension had a substantial negative effect on right ventricular and septal flows, which was exacerbated by greater metabolic demands. These findings highlight the importance of interactions between coronary arterial dominance and hypertension in modulating coronary hemodynamics.

  19. A generic probability based model to derive regional patterns of crops in time and space

    Science.gov (United States)

    Wattenbach, Martin; Luedtke, Stefan; Redweik, Richard; van Oijen, Marcel; Balkovic, Juraj; Reinds, Gert Jan

    2015-04-01

    Croplands are not only the key to human food supply, they also change the biophysical and biogeochemical properties of the land surface leading to changes in the water cycle, energy portioning, they influence soil erosion and substantially contribute to the amount of greenhouse gases entering the atmosphere. The effects of croplands on the environment depend on the type of crop and the associated management which both are related to the site conditions, economic boundary settings as well as preferences of individual farmers. The method described here is designed to predict the most probable crop to appear at a given location and time. The method uses statistical crop area information on NUTS2 level from EUROSTAT and the Common Agricultural Policy Regionalized Impact Model (CAPRI) as observation. These crops are then spatially disaggregated to the 1 x 1 km grid scale within the region, using the assumption that the probability of a crop appearing at a given location and a given year depends on a) the suitability of the land for the cultivation of the crop derived from the MARS Crop Yield Forecast System (MCYFS) and b) expert knowledge of agricultural practices. The latter includes knowledge concerning the feasibility of one crop following another (e.g. a late-maturing crop might leave too little time for the establishment of a winter cereal crop) and the need to combat weed infestations or crop diseases. The model is implemented in R and PostGIS. The quality of the generated crop sequences per grid cell is evaluated on the basis of the given statistics reported by the joint EU/CAPRI database. The assessment is given on NUTS2 level using per cent bias as a measure with a threshold of 15% as minimum quality. The results clearly indicates that crops with a large relative share within the administrative unit are not as error prone as crops that allocate only minor parts of the unit. However, still roughly 40% show an absolute per cent bias above the 15% threshold. This

  20. Finding generically stable measures

    CERN Document Server

    Simon, Pierre

    2010-01-01

    We discuss two constructions for obtaining generically stable Keisler measures in an NIP theory. First, we show how to symmetrize an arbitrary invariant measure to obtain a generically stable one from it. Next, we show that suitable sigma-additive probability measures give rise to generically stable measures. Also included is a proof that generically stable measures over o-minimal theories and the p-adics are smooth.

  1. Natural ventilation of a generic cask under a transport hood - CFD and analytical modelling

    Energy Technology Data Exchange (ETDEWEB)

    Powell, D.; Davies, G.; Tso, C.F. [Arup, London (United Kingdom)

    2004-07-01

    In comparison with finite element simulation for structural and thermal behaviour, the use of computational fluid dynamics technique (hereafter CFD) to analyse, predict and design air and heat flow in package design is relatively novel. Arup has been using CFD techniques to investigate fluid and heat flow, and to use it as a tool to design fluid and heat flow across a broad spectrum of industries for over fifteen years. In order demonstrate the power of the technique and its benefits, the airflow and heat flow characteristics around a transport package during transit under a transport hood has been evaluated using the CFD technique. This paper presents the scenario, the model, the analysis technique and the results of this analysis. Comparison with test results is probably the best way to validate a CFD analysis. In the absence of test results, the analysis was verified by comparison with hand calculation solutions. The scenario as it stands is too complex and hand calculation solution cannot describe the scenario sufficiently. However, hand calculation solutions could be derived for simplified version of the scenario against which CFD analysis of the simplified scenario can be compared. The second half of this paper describes the verification out.

  2. Comparing generic models for interplanetary shocks and magnetic clouds axis configurations at 1 AU

    CERN Document Server

    Janvier, Miho; Demoulin, Pascal; Masias-Meza, Jimmy; Lugaz, Noe

    2015-01-01

    Interplanetary Coronal Mass Ejections are the manifestation of solar transient eruptions, which can significantly modify the plasma and magnetic conditions in the heliosphere. They are often preceded by a shock, and a magnetic flux rope is detected in situ in a third to half of them. The main aim of this study is to obtain the best quantitative shape for the flux rope axis and for the shock surface from in situ data obtained during spacecraft crossings of these structures. We first compare the orientation of the flux ropes axes and shock normals obtained from independent data analyses of the same events, observed in situ at 1AU from the Sun. Then, we carry out an original statistical analysis of axes/shock normals by deriving the statistical distributions of their orientations. We fit the observed distributions using the distributions derived from several synthetic models describing these shapes. We show that the distributions of axis/shock orientations are very sensitive to their respective shape. One classi...

  3. An Agent-Based Modeling Framework and Application for the Generic Nuclear Fuel Cycle

    Science.gov (United States)

    Gidden, Matthew J.

    Key components of a novel methodology and implementation of an agent-based, dynamic nuclear fuel cycle simulator, Cyclus , are presented. The nuclear fuel cycle is a complex, physics-dependent supply chain. To date, existing dynamic simulators have not treated constrained fuel supply, time-dependent, isotopic-quality based demand, or fuel fungibility particularly well. Utilizing an agent-based methodology that incorporates sophisticated graph theory and operations research techniques can overcome these deficiencies. This work describes a simulation kernel and agents that interact with it, highlighting the Dynamic Resource Exchange (DRE), the supply-demand framework at the heart of the kernel. The key agent-DRE interaction mechanisms are described, which enable complex entity interaction through the use of physics and socio-economic models. The translation of an exchange instance to a variant of the Multicommodity Transportation Problem, which can be solved feasibly or optimally, follows. An extensive investigation of solution performance and fidelity is then presented. Finally, recommendations for future users of Cyclus and the DRE are provided.

  4. The generic article

    NARCIS (Netherlands)

    Farkas, D.F.; Swart, Henriëtte de

    2005-01-01

    We take a fresh look at the connection between genericity and (in)definiteness by reconsidering a long-standing puzzle concerning the relation between definiteness and genericity. We contrast English on the one hand and Romance languages and Hungarian on the other, focusing on generic sentences invo

  5. Numerical Modeling of Thermal-Hydrology in the Near Field of a Generic High-Level Waste Repository

    Science.gov (United States)

    Matteo, E. N.; Hadgu, T.; Park, H.

    2016-12-01

    Disposal in a deep geologic repository is one of the preferred option for long term isolation of high-level nuclear waste. Coupled thermal-hydrologic processes induced by decay heat from the radioactive waste may impact fluid flow and the associated migration of radionuclides. This study looked at the effects of those processes in simulations of thermal-hydrology for the emplacement of U. S. Department of Energy managed high-level waste and spent nuclear fuel. Most of the high-level waste sources have lower thermal output which would reduce the impact of thermal propagation. In order to quantify the thermal limits this study concentrated on the higher thermal output sources and on spent nuclear fuel. The study assumed a generic nuclear waste repository at 500 m depth. For the modeling a representative domain was selected representing a portion of the repository layout in order to conduct a detailed thermal analysis. A highly refined unstructured mesh was utilized with refinements near heat sources and at intersections of different materials. Simulations looked at different values for properties of components of the engineered barrier system (i.e. buffer, disturbed rock zone and the host rock). The simulations also looked at the effects of different durations of surface aging of the waste to reduce thermal perturbations. The PFLOTRAN code (Hammond et al., 2014) was used for the simulations. Modeling results for the different options are reported and include temperature and fluid flow profiles in the near field at different simulation times. References:G. E. Hammond, P.C. Lichtner and R.T. Mills, "Evaluating the Performance of Parallel Subsurface Simulators: An Illustrative Example with PFLOTRAN", Water Resources Research, 50, doi:10.1002/2012WR013483 (2014). Sandia National Laboratories is a multiprogram laboratory operated by Sandia Corporation, a Lockheed Martin Company, for the United States Department of Energy's National Nuclear Security Administration under

  6. Data-driven sampling method for building 3D anatomical models from serial histology

    Science.gov (United States)

    Salunke, Snehal Ulhas; Ablove, Tova; Danforth, Theresa; Tomaszewski, John; Doyle, Scott

    2017-03-01

    In this work, we investigate the effect of slice sampling on 3D models of tissue architecture using serial histopathology. We present a method for using a single fully-sectioned tissue block as pilot data, whereby we build a fully-realized 3D model and then determine the optimal set of slices needed to reconstruct the salient features of the model objects under biological investigation. In our work, we are interested in the 3D reconstruction of microvessel architecture in the trigone region between the vagina and the bladder. This region serves as a potential avenue for drug delivery to treat bladder infection. We collect and co-register 23 serial sections of CD31-stained tissue images (6 μm thick sections), from which four microvessels are selected for analysis. To build each model, we perform semi-automatic segmentation of the microvessels. Subsampled meshes are then created by removing slices from the stack, interpolating the missing data, and re-constructing the mesh. We calculate the Hausdorff distance between the full and subsampled meshes to determine the optimal sampling rate for the modeled structures. In our application, we found that a sampling rate of 50% (corresponding to just 12 slices) was sufficient to recreate the structure of the microvessels without significant deviation from the fullyrendered mesh. This pipeline effectively minimizes the number of histopathology slides required for 3D model reconstruction, and can be utilized to either (1) reduce the overall costs of a project, or (2) enable additional analysis on the intermediate slides.

  7. Development of a new generation of high-resolution anatomical models for medical device evaluation: the Virtual Population 3.0

    Science.gov (United States)

    Gosselin, Marie-Christine; Neufeld, Esra; Moser, Heidi; Huber, Eveline; Farcito, Silvia; Gerber, Livia; Jedensjö, Maria; Hilber, Isabel; Di Gennaro, Fabienne; Lloyd, Bryn; Cherubini, Emilio; Szczerba, Dominik; Kainz, Wolfgang; Kuster, Niels

    2014-09-01

    The Virtual Family computational whole-body anatomical human models were originally developed for electromagnetic (EM) exposure evaluations, in particular to study how absorption of radiofrequency radiation from external sources depends on anatomy. However, the models immediately garnered much broader interest and are now applied by over 300 research groups, many from medical applications research fields. In a first step, the Virtual Family was expanded to the Virtual Population to provide considerably broader population coverage with the inclusion of models of both sexes ranging in age from 5 to 84 years old. Although these models have proven to be invaluable for EM dosimetry, it became evident that significantly enhanced models are needed for reliable effectiveness and safety evaluations of diagnostic and therapeutic applications, including medical implants safety. This paper describes the research and development performed to obtain anatomical models that meet the requirements necessary for medical implant safety assessment applications. These include implementation of quality control procedures, re-segmentation at higher resolution, more-consistent tissue assignments, enhanced surface processing and numerous anatomical refinements. Several tools were developed to enhance the functionality of the models, including discretization tools, posing tools to expand the posture space covered, and multiple morphing tools, e.g., to develop pathological models or variations of existing ones. A comprehensive tissue properties database was compiled to complement the library of models. The results are a set of anatomically independent, accurate, and detailed models with smooth, yet feature-rich and topologically conforming surfaces. The models are therefore suited for the creation of unstructured meshes, and the possible applications of the models are extended to a wider range of solvers and physics. The impact of these improvements is shown for the MRI exposure of an adult

  8. Application of an anatomically-detailed finite element thorax model to investigate pediatric cardiopulmonary resuscitation techniques on hard bed.

    Science.gov (United States)

    Jiang, Binhui; Mao, Haojie; Cao, Libo; Yang, King H

    2014-09-01

    Improved Cardiopulmonary Resuscitation (CPR) approaches will largely benefit the children in need. The constant peak displacement and constant peak force loading methods were analyzed on hard bed for pediatric CPR by an anatomically-detailed 10 year-old (YO) child thorax finite element (FE) model. The chest compression and rib injury risk were studied for children with various levels of thorax stiffness. We created three thorax models with different chest stiffness. Simulated CPR׳s in the above two conditions were performed. Three different compression rates were considered under the constant peak displacement condition. The model-calculated deflections and forces were analyzed. The rib maximum principle strains (MPS׳s) were used to predict the potential risk of rib injury. Under the constant peak force condition, the chest deflection ranged from 34.2 to 42.2mm. The highest rib MPS was 0.75%, predicted by the compliant thorax model. Under the normal constant peak displacement condition, the highest rib MPS was 0.52%, predicted by the compliant thorax model. The compression rate did not affect the highest rib MPS. Results revealed that the thoracic stiffness had great effects on the quality of CPR. To maintain CPR quality for various children, the constant peak displacement technique is recommended when the CPR is performed on the hard bed. Furthermore, the outcome of CPR in terms of rib strains and total work are not sensitive to the compression rate. The FE model-predicted high strains were in the ribs, which have been found to be vulnerable to CPR in the literature. Copyright © 2014 Elsevier Ltd. All rights reserved.

  9. GENERIC COMMODITY PROMOTION AND PRODUCT DIFFERENTIATION

    OpenAIRE

    1999-01-01

    This paper considers whether generic promotion lowers the differentiation among competing brands as claimed in the 1997 Supreme Court case (Wileman et al. v. Glickman). Commodity promotion is modeled as a multi-stage game where products are vertically differentiated. Analytical results show that if the benefits of generic advertising from increased demand are outweighed by the costs from lower product differentiation then high-quality producers will not benefit from generic promotion but prod...

  10. Lumbar spine segmentation using a statistical multi-vertebrae anatomical shape+pose model.

    Science.gov (United States)

    Rasoulian, Abtin; Rohling, Robert; Abolmaesumi, Purang

    2013-10-01

    Segmentation of the spinal column from computed tomography (CT) images is a preprocessing step for a range of image-guided interventions. One intervention that would benefit from accurate segmentation is spinal needle injection. Previous spinal segmentation techniques have primarily focused on identification and separate segmentation of each vertebra. Recently, statistical multi-object shape models have been introduced to extract common statistical characteristics between several anatomies. These models can be used for segmentation purposes because they are robust, accurate, and computationally tractable. In this paper, we develop a statistical multi-vertebrae shape+pose model and propose a novel registration-based technique to segment the CT images of spine. The multi-vertebrae statistical model captures the variations in shape and pose simultaneously, which reduces the number of registration parameters. We validate our technique in terms of accuracy and robustness of multi-vertebrae segmentation of CT images acquired from lumbar vertebrae of 32 subjects. The mean error of the proposed technique is below 2 mm, which is sufficient for many spinal needle injection procedures, such as facet joint injections.

  11. How Spatial Abilities and Dynamic Visualizations Interplay When Learning Functional Anatomy with 3D Anatomical Models

    Science.gov (United States)

    Berney, Sandra; Bétrancourt, Mireille; Molinari, Gaëlle; Hoyek, Nady

    2015-01-01

    The emergence of dynamic visualizations of three-dimensional (3D) models in anatomy curricula may be an adequate solution for spatial difficulties encountered with traditional static learning, as they provide direct visualization of change throughout the viewpoints. However, little research has explored the interplay between learning material…

  12. Morphing patient-specific musculoskeletal models

    DEFF Research Database (Denmark)

    Rasmussen, John; Galibarov, Pavel E.; Al-Munajjed, Amir;

    Anatomically realistic musculoskeletal models tend to be very complicated. The current full-body model of the AnyScript Model Repository comprises more than 1000 individually activated muscles and hundreds of bones and joints, and the development of these generic body parts represents an investment...... the generic model differs significantly from the patient in question. The scenario therefore entails two sets of data: (i) a generic musculoskeletal model representing a single (average) individual, and (ii) a set of 3-D medical imaging data, typically in the form of a DICOM file obtained from CT, MRI...... or surface scans. Furthermore, we assume that a set of corresponding anatomical landmarks can be identified in the medical imaging data and on the generic musculoskeletal model. A nonlinear transformation, i.e. a morphing, is created by means of radial basis functions that maps points set (i) to point set...

  13. Generic experiments at the sump model 'Zittauer Stroemungswanne' (ZSW) for the behaviour of mineral wool in the sump and the reactor core

    Energy Technology Data Exchange (ETDEWEB)

    Alt, Soeren; Hampel, R.; Kaestner, Wolfgang [Hochschule Zittau/Goerlitz (DE)] (and others)

    2011-03-15

    The investigation of insulation debris transport, sedimentation, penetration into the reactor core and head loss build up becomes important to reactor safety research for PWR and BWR, when considering the long-term behaviour of emergency core cooling systems during loss of coolant accidents. Research projects are being performed in cooperation between the University of Applied Sciences Zittau/Goerlitz and the Helmholtz-Zentrum Dresden-Rossendorf. The projects include experimental investigations of different processes and phenomena of insulation debris in coolant flow and the development of CFD models. Generic complex experiments serve for building up a data base for the validation of models for single effects and their coupling in CFD codes. This paper includes the description of the experimental facility for complex generic experiments (ZSW), an overview about experimental boundary conditions and results for upstream and down-stream phenomena as well as for the long-time behaviour due to corrosive processes. (orig.)

  14. Solving inaccuracies in anatomical models for electrocardiographic inverse problem resolution by maximizing reconstruction quality.

    Science.gov (United States)

    Rodrigo, Miguel; Climent, Andreu; Liberos, Alejandro; Hernandez-Romero, Ismael; Arenal, Angel; Bermejo, Javier; Fernandez-Aviles, Francisco; Atienza, Felipe; Guillem, Maria

    2017-05-23

    Electrocardiographic Imaging (ECGI) has become an increasingly used technique for non-invasive diagnosis of cardiac arrhythmias, although the need for medical imaging technology to determine the anatomy hinders its introduction in the clinical practice. This work explores the ability of a new metric based on the inverse reconstruction quality for the location and orientation of the atrial surface inside the torso. Body surface electrical signals from 31 realistic mathematical models and four AF patients were used to estimate the optimal position of the atria inside the torso. The curvature of the L-curve from the Tikhonov method, which was found to be related to the inverse reconstruction quality, was measured after application of deviations in atrial position and orientation. Independent deviations in the atrial position were solved by finding the maximal L-curve curvature with an error of 1.7±2.4 mm in mathematical models and 9.1±11.5 mm in patients. For the case of independent angular deviations, the error in location by using the L-curve was 5.8±7.1º in mathematical models and 12.4º±13.2º in patients. The ability of the L-curve curvature was tested also under superimposed uncertainties in the 3 axis of translation and in the 3 axis of rotation and the error in location was of 2.3±3.2 mm and 6.4º±7.1º in mathematical models, and 7.9±10.7 mm and 12.1º±15.5º in patients. The curvature of L-curve is a useful marker for the atrial position and would allow emending the inaccuracies in its location.

  15. A patient-specific respiratory model of anatomical motion for radiation treatment planning

    CERN Document Server

    Zhang, Qinghui; Hertanto, Agung; Hu, Yu-Chi; Rosenzweig, Kenneth E; Ling, C Clifton; Mageras, Gig S

    2007-01-01

    Modeling of respiratory motion is important for a more accurate understanding and accounting of its effect on dose to cancers in the thorax and abdomen by radiotherapy. We have developed a model of respiration-induced organ motion in the thorax, without the commonly adopted assumption of repeatable breath cycles. The model describes the motion of a volume of interest within the patient, based on a reference 3-dimensional image (at end-expiration), and the diaphragm positions at different time points. The input data are respiration-correlated CT images of patients treated for nonsmall cell lung cancer, consisting of 3D images, including the diaphragm positions, at 10 phases of the respiratory cycle. A deformable image registration algorithm calculates the deformation field that maps each 3D image to the reference 3D image. A principle component analysis is performed to parameterize the 3D deformation field in terms of the diaphragm motion. We show that the first two principal components are adequate to accurat...

  16. CLM4-BeTR, a generic biogeochemical transport and reaction module for CLM4: model development, evaluation, and application

    Directory of Open Access Journals (Sweden)

    J. Y. Tang

    2013-01-01

    Full Text Available To improve regional and global biogeochemistry modeling and climate predictability, we have developed a generic reactive transport module for the land model CLM4 (called CLM4-BeTR (Biogeochemical Transport and Reactions. CLM4-BeTR represents the transport, interactions, and biotic and abiotic transformations of an arbitrary number of tracers (aka chemical species in an arbitrary number of phases (e.g., dissolved, gaseous, sorbed, aggregate. An operator splitting approach was employed and consistent boundary conditions were derived for each modeled sub-process. Aqueous tracer fluxes, associated with hydrological processes such as surface run-on and run-off, belowground drainage, and ice to liquid conversion were also computed consistently with the bulk water fluxes calculated by the soil physics module in CLM4. The transport code was evaluated and found in good agreement with several analytical test cases using a time step of 30 min. The model was then applied at the Harvard Forest site with a representation of depth-dependent belowground biogeochemistry. The results indicated that, at this site, (1 CLM4-BeTR was able to simulate soil–surface CO2 effluxes and soil CO2 profiles accurately; (2 the transient surface CO2 effluxes calculated based on the tracer transport mechanism were in general not equal to the belowground CO2 production rates with the magnitude of the difference being a function of averaging timescale and site conditions: differences were large (−20 ~ 20% on hourly, smaller (−5 ~ 5% at daily timescales, and persisted to the monthly timescales with a smaller magnitude (<4%; (3 losses of CO2 through processes other than surface gas efflux were less than 1% of the overall soil respiration; and (4 the contributions of root respiration and heterotrophic respiration have distinct temporal signals in surface CO2 effluxes and soil CO2 concentrations. The

  17. Reference pricing with endogenous generic entry.

    OpenAIRE

    Kurt R. Brekke; Canta, Chiara; Straume, Odd Rune

    2015-01-01

    In this paper we study the effect of reference pricing on pharmaceutical prices and ex-penditures when generic entry is endogenously determined. We develop a Salop-type model where a brand-name producer competes with generic producers in terms of prices. In the market there are two types of consumers: (i) brand biased consumers who choose between brand-name and generic drugs, and (ii) brand neutral consumers who choose between the different generic drugs. We find that, for a given number of ...

  18. "Generic Entry and the Pricing of Pharmaceuticals"

    OpenAIRE

    Frank, Richard G.; David S. Salkever

    1995-01-01

    During the 1980s the share of prescriptions sold by retail pharmacies that was accounted for by generic products roughly doubled. The price response to generic entry of brand-name products has been a source of controversy. In this paper we estimate models of price responses to generic entry in the market for brand-name and generic drugs. We study a sample of 32 drugs that lost patent protection during the early to mid-1980s. Our results provide strong evidence that brand-name prices increase ...

  19. Automatic iterative segmentation of multiple sclerosis lesions using Student's t mixture models and probabilistic anatomical atlases in FLAIR images.

    Science.gov (United States)

    Freire, Paulo G L; Ferrari, Ricardo J

    2016-06-01

    Multiple sclerosis (MS) is a demyelinating autoimmune disease that attacks the central nervous system (CNS) and affects more than 2 million people worldwide. The segmentation of MS lesions in magnetic resonance imaging (MRI) is a very important task to assess how a patient is responding to treatment and how the disease is progressing. Computational approaches have been proposed over the years to segment MS lesions and reduce the amount of time spent on manual delineation and inter- and intra-rater variability and bias. However, fully-automatic segmentation of MS lesions still remains an open problem. In this work, we propose an iterative approach using Student's t mixture models and probabilistic anatomical atlases to automatically segment MS lesions in Fluid Attenuated Inversion Recovery (FLAIR) images. Our technique resembles a refinement approach by iteratively segmenting brain tissues into smaller classes until MS lesions are grouped as the most hyperintense one. To validate our technique we used 21 clinical images from the 2015 Longitudinal Multiple Sclerosis Lesion Segmentation Challenge dataset. Evaluation using Dice Similarity Coefficient (DSC), True Positive Ratio (TPR), False Positive Ratio (FPR), Volume Difference (VD) and Pearson's r coefficient shows that our technique has a good spatial and volumetric agreement with raters' manual delineations. Also, a comparison between our proposal and the state-of-the-art shows that our technique is comparable and, in some cases, better than some approaches, thus being a viable alternative for automatic MS lesion segmentation in MRI.

  20. Potential of pedestrian protection systems--a parameter study using finite element models of pedestrian dummy and generic passenger vehicles.

    Science.gov (United States)

    Fredriksson, Rikard; Shin, Jaeho; Untaroiu, Costin D

    2011-08-01

    To study the potential of active, passive, and integrated (combined active and passive) safety systems in reducing pedestrian upper body loading in typical impact configurations. Finite element simulations using models of generic sedan car fronts and the Polar II pedestrian dummy were performed for 3 impact configurations at 2 impact speeds. Chest contact force, head injury criterion (HIC(15)), head angular acceleration, and the cumulative strain damage measure (CSDM(0.25)) were employed as injury parameters. Further, 3 countermeasures were modeled: an active autonomous braking system, a passive deployable countermeasure, and an integrated system combining the active and passive systems. The auto-brake system was modeled by reducing impact speed by 10 km/h (equivalent to ideal full braking over 0.3 s) and introducing a pitch of 1 degree and in-crash deceleration of 1 g. The deployable system consisted of a deployable hood, lifting 100 mm in the rear, and a lower windshield air bag. All 3 countermeasures showed benefit in a majority of impact configurations in terms of injury prevention. The auto-brake system reduced chest force in a majority of the configurations and decreased HIC(15), head angular acceleration, and CSDM in all configurations. Averaging all impact configurations, the auto-brake system showed reductions of injury predictors from 20 percent (chest force) to 82 percent (HIC). The passive deployable countermeasure reduced chest force and HIC(15) in a majority of configurations and head angular acceleration and CSDM in all configurations, although the CSDM decrease in 2 configurations was minimal. On average a reduction from 20 percent (CSDM) to 58 percent (HIC) was recorded in the passive deployable countermeasures. Finally, the integrated system evaluated in this study reduced all injury assessment parameters in all configurations compared to the reference situations. The average reductions achieved by the integrated system ranged from 56 percent

  1. A micro-anatomical model of the distribution of myocardial endomysial collagen.

    Science.gov (United States)

    Macchiarelli, G; Ohtani, O; Nottola, S A; Stallone, T; Camboni, A; Prado, I M; Motta, P M

    2002-01-01

    Myocardial connective tissue probably provides passive support for regulating heart tensile strength and stiffness and ultimately for controlling heart mechanics through its endomysial part. However, endomysial collagen micro-arrangement is still a matter of debate. In order to define the fine distribution of left ventricle endomysial collagen, we applied the NaOH-scanning electron microscopy (SEM) maceration method (one of the techniques of choice for studying collagen micro-arrangement) to rabbit heart. Gomori-reticulum staining was used for correlated light microscopy (LM) observations. The SEM-NaOH method allowed isolation of collagen by removing other extracellular matrix components and cells and preserved collagen structure and position. Endomysial collagen appeared arranged in laminae that delimited the lacunae that were left empty by macerated myocytes and small vessels (mostly capillaries). These laminae were formed by reticular fibers, as confirmed by LM observations of Gomorireticulum-stained samples, and were organized in irregularly meshed networks made of thin (single) and thick (composed) filaments. In longitudinal views, collagen laminae extended the entire length of lacunae. In transversal views, the cut surface of the laminae appeared to be made of collagen bundles. These observations provide an updated microanatomical view of endomysial collagen distribution, which integrates previous studies. This model is based on the evidence that collagen laminae enveloped the surface of small vessels and myocytes. Thus, a type of myocyte-myocyte or capillary-myocyte "laminar connection" anchored to the entire cell length here is emphasized, rather than a type of "strut connection" anchored to defined loci, as usually described. This structure explains better how endomysium may provide the necessary support for heart compliance and protection against overstretch.

  2. A generic and systematic procedure to derive a simplified model from the Anaerobic Digestion Model No. 1 (ADM1)

    OpenAIRE

    Ficara, E.; Leva, A.; Harmand, Jérôme

    2015-01-01

    The Anaerobic Digestion Model No.1 (ADM1) developed by the IWA Task Group for mathematical modelling of anaerobic digestion processes (Batstone et al. (2001) [1]) is a structural model which describes the main biochemical and physicochemical processes. For such purposes, other models have been proposed to describe anaerobic processes with a reduced set of parameters, state variables and processes. Among them, the Anaerobic Model No. 2 (AM2) proposed by Bernard et al. (2001) [2] which describe...

  3. Force of habit: shrubs, trees and contingent evolution of wood anatomical diversity using Croton (Euphorbiaceae) as a model system.

    Science.gov (United States)

    Arévalo, Rafael; van Ee, Benjamin W; Riina, Ricarda; Berry, Paul E; Wiedenhoeft, Alex C

    2017-03-01

    Wood is a major innovation of land plants, and is usually a central component of the body plan for two major plant habits: shrubs and trees. Wood anatomical syndromes vary between shrubs and trees, but no prior work has explicitly evaluated the contingent evolution of wood anatomical diversity in the context of these plant habits. Phylogenetic comparative methods were used to test for contingent evolution of habit, habitat and wood anatomy in the mega-diverse genus Croton (Euphorbiaceae), across the largest and most complete molecular phylogeny of the genus to date. Plant habit and habitat are highly correlated, but most wood anatomical features correlate more strongly with habit. The ancestral Croton was reconstructed as a tree, the wood of which is inferred to have absent or indistinct growth rings, confluent-like axial parenchyma, procumbent ray cells and disjunctive ray parenchyma cell walls. The taxa sampled showed multiple independent origins of the shrub habit in Croton , and this habit shift is contingent on several wood anatomical features (e.g. similar vessel-ray pits, thick fibre walls, perforated ray cells). The only wood anatomical trait correlated with habitat and not habit was the presence of helical thickenings in the vessel elements of mesic Croton . Plant functional traits, individually or in suites, are responses to multiple and often confounding contexts in evolution. By establishing an explicit contingent evolutionary framework, the interplay between habit, habitat and wood anatomical diversity was dissected in the genus Croton . Both habit and habitat influence the evolution of wood anatomical characters, and conversely, the wood anatomy of lineages can affect shifts in plant habit and habitat. This study hypothesizes novel putatively functional trait associations in woody plant structure that could be further tested in a variety of other taxa.

  4. Typed generic traversals in $S_gamma^'$

    NARCIS (Netherlands)

    Lämmel, R.

    2001-01-01

    A typed model of strategic rewriting is developed. An innovation is that generic traversals are covered. To this end, we define a rewriting calculus $S'_{gamma$. The calculus offers a few strategy combinators for generic traversals. There is, for example, a combinator to apply a strategy to all imme

  5. Generic Hurricane Extreme Seas State

    DEFF Research Database (Denmark)

    Wehmeyer, Christof; Skourup, Jesper; Frigaard, Peter

    2012-01-01

    the US east coast and the Gulf of Mexico (1851 - 2009) and Japanese east coast (1951 -2009) form the basis for Weibull extreme value analyses to determine return period respective maximum wind speeds. Unidirectional generic sea state spectra are obtained by application of the empirical models...

  6. Determinants of generic drug substitution in Switzerland

    Directory of Open Access Journals (Sweden)

    Lufkin Thomas M

    2011-01-01

    Full Text Available Abstract Background Since generic drugs have the same therapeutic effect as the original formulation but at generally lower costs, their use should be more heavily promoted. However, a considerable number of barriers to their wider use have been observed in many countries. The present study examines the influence of patients, physicians and certain characteristics of the generics' market on generic substitution in Switzerland. Methods We used reimbursement claims' data submitted to a large health insurer by insured individuals living in one of Switzerland's three linguistic regions during 2003. All dispensed drugs studied here were substitutable. The outcome (use of a generic or not was modelled by logistic regression, adjusted for patients' characteristics (gender, age, treatment complexity, substitution groups and with several variables describing reimbursement incentives (deductible, co-payments and the generics' market (prices, packaging, co-branded original, number of available generics, etc.. Results The overall generics' substitution rate for 173,212 dispensed prescriptions was 31%, though this varied considerably across cantons. Poor health status (older patients, complex treatments was associated with lower generic use. Higher rates were associated with higher out-of-pocket costs, greater price differences between the original and the generic, and with the number of generics on the market, while reformulation and repackaging were associated with lower rates. The substitution rate was 13% lower among hospital physicians. The adoption of the prescribing practices of the canton with the highest substitution rate would increase substitution in other cantons to as much as 26%. Conclusions Patient health status explained a part of the reluctance to substitute an original formulation by a generic. Economic incentives were efficient, but with a moderate global effect. The huge interregional differences indicated that prescribing behaviours and

  7. Solvable model of a generic trapped mixture of interacting bosons: reduced density matrices and proof of Bose-Einstein condensation

    Science.gov (United States)

    Alon, Ofir E.

    2017-07-01

    A mixture of two kinds of identical bosons, species 1 with N 1 bosons of mass m 1 and species 2 with N 2 bosons of mass m 2, held in a harmonic potential of frequency ω and interacting by harmonic intra-species and inter-species particle-particle interactions of strengths λ1 , λ2 , and λ12 is discussed. This is an exactly-solvable model of a generic mixture of trapped interacting bosons which allows one to investigate and determine analytically properties of interest. To start, closed form expressions for the frequencies, ground-state energy, and wave-function of the mixture are obtained and briefly analyzed as a function of the masses, numbers of particles, and strengths and signs of interactions. To prove Bose-Einstein condensation of the mixture three steps are needed. First, we integrate the all-particle density matrix, employing a four-parameter matrix-recurrence relations, down to the lowest-order intra-species and inter-species reduced density matrices of the mixture. Second, the coupled Gross-Pitaevskii (mean-field) equations of the mixture are solved analytically. Third, we analyze the mixture’s reduced density matrices in the limit of an infinite number of particles of both species 1 and 2 (when the interaction parameters, i.e. the products of the number of particles times the intra-species and inter-species interaction strengths, are held fixed) and prove that: (i) both species 1 and 2 are 100% condensed; (ii) the inter-species reduced density matrix per particle is separable and given by the product of the intra-species reduced density matrices per particle; and (iii) the mixture’s energy per particle, and reduced density matrices and densities per particle all coincide with the Gross-Pitaevskii quantities. Finally, when the infinite-particle limit is taken with respect to, say, species 1 only (with interaction parameters held fixed) we prove that: (iv) only species 1 is 100% condensed and its reduced density matrix and density per particle, as

  8. micrOMEGAs 2.0: A program to calculate the relic density of dark matter in a generic model

    Science.gov (United States)

    Bélanger, G.; Boudjema, F.; Pukhov, A.; Semenov, A.

    2007-03-01

    micrOMEGAs 2.0 is a code which calculates the relic density of a stable massive particle in an arbitrary model. The underlying assumption is that there is a conservation law like R-parity in supersymmetry which guarantees the stability of the lightest odd particle. The new physics model must be incorporated in the notation of CalcHEP, a package for the automatic generation of squared matrix elements. Once this is done, all annihilation and coannihilation channels are included automatically in any model. Cross-sections at v=0, relevant for indirect detection of dark matter, are also computed automatically. The package includes three sample models: the minimal supersymmetric standard model (MSSM), the MSSM with complex phases and the NMSSM. Extension to other models, including non-supersymmetric models, is described. Program summaryTitle of program:micrOMEGAs2.0 Catalogue identifier:ADQR_v2_0 Program summary URL:http://cpc.cs.qub.ac.uk/summaries/ADQR_v2_0 Program obtainable from: CPC Program Library, Queen's University of Belfast, N. Ireland Computers for which the program is designed and others on which it has been tested:PC, Alpha, Mac, Sun Operating systems under which the program has been tested:UNIX (Linux, OSF1, SunOS, Darwin, Cygwin) Programming language used:C and Fortran Memory required to execute with typical data:17 MB depending on the number of processes required No. of processors used:1 Has the code been vectorized or parallelized:no No. of lines in distributed program, including test data, etc.:91 778 No. of bytes in distributed program, including test data, etc.:1 306 726 Distribution format:tar.gz External routines/libraries used:no Catalogue identifier of previous version:ADQR_v1_3 Journal reference of previous version:Comput. Phys. Comm. 174 (2006) 577 Does the new version supersede the previous version:yes Nature of physical problem:Calculation of the relic density of the lightest stable particle in a generic new model of particle physics. Method

  9. Utilisation of real-scale renewable energy test facility for validation of generic wind turbine and wind power plant controller models

    Energy Technology Data Exchange (ETDEWEB)

    Zeni, Lorenzo; Hesselbæk, Bo; Bech, John; Sørensen, Poul Ejnar; Gevorgian, Vahan; Wallen, Robb

    2016-09-01

    This article presents an example of application of a modern test facility conceived for experiments regarding the integration of renewable energy in the power system. The capabilities of the test facility are used to validate dynamic simulation models of wind power plants and their controllers. The models are based on standard and generic blocks. The successful validation of events related to the control of active power (control phenomena in <10 Hz range, including frequency control and power oscillation damping) is described, demonstrating the capabilities of the test facility and drawing the track for future work and improvements.

  10. Process-based modelling of fluvial system response to rapid climate change: 1. model formulation and generic applications

    NARCIS (Netherlands)

    Bogaart, P.W.; Balen, van R.T.; Kasse, C.; Vandenberghe, J.

    2003-01-01

    A comprehensive model strategy is presented which enables the prediction of catchment hydrology and the dynamics of sediment transport within the alluvial river systems draining these catchments. The model is driven by AGCM-based weather predictions, generalised by using a stochastic weather generat

  11. Process-based modelling of fluvial system response to rapid climate change: 1. model formulation and generic applications

    NARCIS (Netherlands)

    Bogaart, P.W.; Balen, van R.T.; Kasse, C.; Vandenberghe, J.

    2003-01-01

    A comprehensive model strategy is presented which enables the prediction of catchment hydrology and the dynamics of sediment transport within the alluvial river systems draining these catchments. The model is driven by AGCM-based weather predictions, generalised by using a stochastic weather generat

  12. Process-based modelling of fluvial system response to rapid climate change: 1. model formulation and generic applications

    NARCIS (Netherlands)

    Bogaart, P.W.; Balen, van R.T.; Kasse, C.; Vandenberghe, J.

    2003-01-01

    A comprehensive model strategy is presented which enables the prediction of catchment hydrology and the dynamics of sediment transport within the alluvial river systems draining these catchments. The model is driven by AGCM-based weather predictions, generalised by using a stochastic weather

  13. Dimensional regularization is generic

    CERN Document Server

    Fujikawa, Kazuo

    2016-01-01

    The absence of the quadratic divergence in the Higgs sector of the Standard Model in the dimensional regularization is usually regarded to be an exceptional property of a specific regularization. To understand what is going on in the dimensional regularization, we illustrate how to reproduce the results of the dimensional regularization for the $\\lambda\\phi^{4}$ theory in the more conventional regularization such as the higher derivative regularization; the basic postulate involved is that the quadratically divergent induced mass, which is independent of the scale change of the physical mass, is kinematical and unphysical. This is consistent with the derivation of the Callan-Symanzik equation, which is a comparison of two theories with slightly different masses, for the $\\lambda\\phi^{4}$ theory without encountering the quadratic divergence. We thus suggest that the dimensional regularization is generic in a bottom-up approach starting with a successful low-energy theory. We also define a modified version of t...

  14. The use of a new 3D splint and double CT scan procedure to obtain an accurate anatomic virtual augmented model of the skull.

    Science.gov (United States)

    Swennen, G R J; Barth, E-L; Eulzer, C; Schutyser, F

    2007-02-01

    Three-dimensional (3D) virtual planning of orthognathic surgery requires detailed visualization of the interocclusal relationship. The purpose of this study was to introduce the modification of the double computed tomography (CT) scan procedure using a newly designed 3D splint in order to obtain a detailed anatomic 3D virtual augmented model of the skull. A total of 10 dry adult human cadaver skulls were used to evaluate the accuracy of the automatic rigid registration method for fusion of both CT datasets (Maxilim, version 1.3.0). The overall mean registration error was 0.1355+/-0.0323 mm (range 0.0760-0.1782 mm). Analysis of variance showed a registration method error of 0.0564 mm (P 3D splint with the double CT scan procedure allowed accurate registration and the set-up of an accurate anatomic 3D virtual augmented model of the skull with detailed dental surface.

  15. THE DEVELOPMENT OF LABORATORY-BASED EARTH AND SPACE SCIENCE LEARNING MODEL TO IMPROVE SCIENCE GENERIC SKILLS OF PRE-SERVICE TEACHERS

    Directory of Open Access Journals (Sweden)

    R. Rosnita

    2016-10-01

    Full Text Available This study focuses on the improvement of prospective teachers’ science generic skills in learning for earth and space sciences subject using a laboratory-based model.  Research methods were Research and Development used mixed methods design, i.e. Embedded Experimental models. The results showed that the structure of the learning using laboratory-based model consists of four stages, namely engagement, exploration, explanation, and elaboration; with details on description of natural phenomena, the identification of questions, linking concepts with practical topic; modeling, training, exploration, interpretation of data, conclude, and communicate the procedures and results of the investigation. Moreover, the ability of science generic skills of teacher candidates was low at 52.50%. In addition, the profile of lecturer performance in learning reached 55%. Also, the condition of the learning environment is generally sufficient in supporting the development of laboratory activities, for example: a comfortable laboratory room for conducting the practicum. Next, 75% student agreed that for understand the material; it needs a practice in lab. As many as 70% of students agreed that practicum will increase students' understanding, although students also agreed that clarification is still required by lecturers (80%. Furthermore, 69% of the students found the materials of Earth and Space Sciences ismore attractive than other materials, although 78% said material of Earth and Space Sciences is fairly complicated and abstract. The interest of students to the material of Earth and Space Sciences is because these materials can foster curiosity (88% as well as providing benefits to their daily life (90%. Finally, three out of four students agreed that the science generic skills can develop the ability of scientific work and critical thinking.

  16. Numerical modelling of fault reactivation in carbonate rocks under fluid depletion conditions - 2D generic models with a small isolated fault

    Science.gov (United States)

    Zhang, Yanhua; Clennell, Michael B.; Delle Piane, Claudio; Ahmed, Shakil; Sarout, Joel

    2016-12-01

    This generic 2D elastic-plastic modelling investigated the reactivation of a small isolated and critically-stressed fault in carbonate rocks at a reservoir depth level for fluid depletion and normal-faulting stress conditions. The model properties and boundary conditions are based on field and laboratory experimental data from a carbonate reservoir. The results show that a pore pressure perturbation of -25 MPa by depletion can lead to the reactivation of the fault and parts of the surrounding damage zones, producing normal-faulting downthrows and strain localization. The mechanism triggering fault reactivation in a carbonate field is the increase of shear stresses with pore-pressure reduction, due to the decrease of the absolute horizontal stress, which leads to an expanded Mohr's circle and mechanical failure, consistent with the predictions of previous poroelastic models. Two scenarios for fault and damage-zone permeability development are explored: (1) large permeability enhancement of a sealing fault upon reactivation, and (2) fault and damage zone permeability development governed by effective mean stress. In the first scenario, the fault becomes highly permeable to across- and along-fault fluid transport, removing local pore pressure highs/lows arising from the presence of the initially sealing fault. In the second scenario, reactivation induces small permeability enhancement in the fault and parts of damage zones, followed by small post-reactivation permeability reduction. Such permeability changes do not appear to change the original flow capacity of the fault or modify the fluid flow velocity fields dramatically.

  17. Generic Fortran Containers (GFC)

    Energy Technology Data Exchange (ETDEWEB)

    2016-09-01

    The Fortran language does not provide a standard library that implements generic containers, like linked lists, trees, dictionaries, etc. The GFC software provides an implementation of generic Fortran containers natively written in Fortran 2003/2008 language. The following containers are either already implemented or planned: Stack (done), Linked list (done), Tree (done), Dictionary (done), Queue (planned), Priority queue (planned).

  18. Generic torus canards

    Science.gov (United States)

    Vo, Theodore

    2017-10-01

    Torus canards are special solutions of fast/slow systems that alternate between attracting and repelling manifolds of limit cycles of the fast subsystem. A relatively new dynamic phenomenon, torus canards have been found in neural applications to mediate the transition from tonic spiking to bursting via amplitude-modulated spiking. In R3, torus canards are degenerate: they require one-parameter families of 2-fast/1-slow systems in order to be observed and even then, they only occur on exponentially thin parameter intervals. The addition of a second slow variable unfolds the torus canard phenomenon, making it generic and robust. That is, torus canards in fast/slow systems with (at least) two slow variables occur on open parameter sets. So far, generic torus canards have only been studied numerically, and their behaviour has been inferred based on averaging and canard theory. This approach, however, has not been rigorously justified since the averaging method breaks down near a fold of periodics, which is exactly where torus canards originate. In this work, we combine techniques from Floquet theory, averaging theory, and geometric singular perturbation theory to show that the average of a torus canard is a folded singularity canard. In so doing, we devise an analytic scheme for the identification and topological classification of torus canards in fast/slow systems with two fast variables and k slow variables, for any positive integer k. We demonstrate the predictive power of our results in a model for intracellular calcium dynamics, where we explain the mechanisms underlying a novel class of elliptic bursting rhythms, called amplitude-modulated bursting, by constructing the torus canard analogues of mixed-mode oscillations. We also make explicit the connection between our results here with prior studies of torus canards and torus canard explosion in R3, and discuss how our methods can be extended to fast/slow systems of arbitrary (finite) dimension.

  19. A unified deformable (UD) segment model for quantifying total power of anatomical and prosthetic below-knee structures during stance in gait.

    Science.gov (United States)

    Takahashi, Kota Z; Kepple, Thomas M; Stanhope, Steven J

    2012-10-11

    Anatomically-relevant (AR) biomechanical models are traditionally used to quantify joint powers and segmental energies of lower extremity structures during gait. While AR models contain a series of rigid body segments linked together via mechanical joints, prosthetic below-knee structures are often deformable objects without a definable ankle joint. Consequently, the application of AR models for the study of prosthetic limbs has been problematic. The purpose of this study was to develop and validate a unified deformable (UD) segment model for quantifying the total power of below-knee structures. Estimates of total below-knee power derived via the UD segment model were compared to those derived via an AR model during stance in gait of eleven healthy subjects. The UD segment model achieved similar results to the AR model. Differences in peak power, total positive work, and total negative work were 1.91±0.31%, 3.97±0.49%, and 1.39±0.33%, relative to the AR model estimates. The main advantage of the UD segment model is that it does not require the definition of an ankle joint or foot structures. Therefore, this technique may be valuable for facilitating direct comparisons between anatomical and disparate prosthetic below-knee structures in future studies.

  20. Development and validation of a generic reduced chemical kinetic mechanism for CFD spray combustion modelling of biodiesel fuels

    DEFF Research Database (Denmark)

    Cheng, Xinwei; Ng, Hoon Kiat; Ho, Jee Hou

    2015-01-01

    In this reported work, a generic reduced biodiesel chemical kinetic mechanism, with components of methyl decanoate (C11H22O2, MD), methyl-9-decenoate (C11H20O2, MD9D) and n-heptane (C7H16) was built to represent the methyl esters of coconut, palm, rapeseed and soybean. The reduced biodiesel...... and detailed mechanism predictions, for each zero-dimensional (0D) auto-ignition and extinction process using CHEMKIN-PRO. Maximum percentage errors of less than 40.0% were recorded when the predicted ignition delay (ID) periods for coconut, palm, rapeseed and soybean methyl esters were compared to those...

  1. A generic high-dose rate (192)Ir brachytherapy source for evaluation of model-based dose calculations beyond the TG-43 formalism.

    Science.gov (United States)

    Ballester, Facundo; Carlsson Tedgren, Åsa; Granero, Domingo; Haworth, Annette; Mourtada, Firas; Fonseca, Gabriel Paiva; Zourari, Kyveli; Papagiannis, Panagiotis; Rivard, Mark J; Siebert, Frank-André; Sloboda, Ron S; Smith, Ryan L; Thomson, Rowan M; Verhaegen, Frank; Vijande, Javier; Ma, Yunzhi; Beaulieu, Luc

    2015-06-01

    In order to facilitate a smooth transition for brachytherapy dose calculations from the American Association of Physicists in Medicine (AAPM) Task Group No. 43 (TG-43) formalism to model-based dose calculation algorithms (MBDCAs), treatment planning systems (TPSs) using a MBDCA require a set of well-defined test case plans characterized by Monte Carlo (MC) methods. This also permits direct dose comparison to TG-43 reference data. Such test case plans should be made available for use in the software commissioning process performed by clinical end users. To this end, a hypothetical, generic high-dose rate (HDR) (192)Ir source and a virtual water phantom were designed, which can be imported into a TPS. A hypothetical, generic HDR (192)Ir source was designed based on commercially available sources as well as a virtual, cubic water phantom that can be imported into any TPS in DICOM format. The dose distribution of the generic (192)Ir source when placed at the center of the cubic phantom, and away from the center under altered scatter conditions, was evaluated using two commercial MBDCAs [Oncentra(®) Brachy with advanced collapsed-cone engine (ACE) and BrachyVision ACUROS™ ]. Dose comparisons were performed using state-of-the-art MC codes for radiation transport, including ALGEBRA, BrachyDose, GEANT4, MCNP5, MCNP6, and PENELOPE2008. The methodologies adhered to recommendations in the AAPM TG-229 report on high-energy brachytherapy source dosimetry. TG-43 dosimetry parameters, an along-away dose-rate table, and primary and scatter separated (PSS) data were obtained. The virtual water phantom of (201)(3) voxels (1 mm sides) was used to evaluate the calculated dose distributions. Two test case plans involving a single position of the generic HDR (192)Ir source in this phantom were prepared: (i) source centered in the phantom and (ii) source displaced 7 cm laterally from the center. Datasets were independently produced by different investigators. MC results were then

  2. A generic high-dose rate {sup 192}Ir brachytherapy source for evaluation of model-based dose calculations beyond the TG-43 formalism

    Energy Technology Data Exchange (ETDEWEB)

    Ballester, Facundo, E-mail: Facundo.Ballester@uv.es [Department of Atomic, Molecular and Nuclear Physics, University of Valencia, Burjassot 46100 (Spain); Carlsson Tedgren, Åsa [Department of Medical and Health Sciences (IMH), Radiation Physics, Faculty of Health Sciences, Linköping University, Linköping SE-581 85, Sweden and Department of Medical Physics, Karolinska University Hospital, Stockholm SE-171 76 (Sweden); Granero, Domingo [Department of Radiation Physics, ERESA, Hospital General Universitario, Valencia E-46014 (Spain); Haworth, Annette [Department of Physical Sciences, Peter MacCallum Cancer Centre and Royal Melbourne Institute of Technology, Melbourne, Victoria 3000 (Australia); Mourtada, Firas [Department of Radiation Oncology, Helen F. Graham Cancer Center, Christiana Care Health System, Newark, Delaware 19713 (United States); Fonseca, Gabriel Paiva [Instituto de Pesquisas Energéticas e Nucleares – IPEN-CNEN/SP, São Paulo 05508-000, Brazil and Department of Radiation Oncology (MAASTRO), GROW, School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht 6201 BN (Netherlands); Zourari, Kyveli; Papagiannis, Panagiotis [Medical Physics Laboratory, Medical School, University of Athens, 75 MikrasAsias, Athens 115 27 (Greece); Rivard, Mark J. [Department of Radiation Oncology, Tufts University School of Medicine, Boston, Massachusetts 02111 (United States); Siebert, Frank-André [Clinic of Radiotherapy, University Hospital of Schleswig-Holstein, Campus Kiel, Kiel 24105 (Germany); Sloboda, Ron S. [Department of Medical Physics, Cross Cancer Institute, Edmonton, Alberta T6G 1Z2, Canada and Department of Oncology, University of Alberta, Edmonton, Alberta T6G 2R3 (Canada); and others

    2015-06-15

    Purpose: In order to facilitate a smooth transition for brachytherapy dose calculations from the American Association of Physicists in Medicine (AAPM) Task Group No. 43 (TG-43) formalism to model-based dose calculation algorithms (MBDCAs), treatment planning systems (TPSs) using a MBDCA require a set of well-defined test case plans characterized by Monte Carlo (MC) methods. This also permits direct dose comparison to TG-43 reference data. Such test case plans should be made available for use in the software commissioning process performed by clinical end users. To this end, a hypothetical, generic high-dose rate (HDR) {sup 192}Ir source and a virtual water phantom were designed, which can be imported into a TPS. Methods: A hypothetical, generic HDR {sup 192}Ir source was designed based on commercially available sources as well as a virtual, cubic water phantom that can be imported into any TPS in DICOM format. The dose distribution of the generic {sup 192}Ir source when placed at the center of the cubic phantom, and away from the center under altered scatter conditions, was evaluated using two commercial MBDCAs [Oncentra{sup ®} Brachy with advanced collapsed-cone engine (ACE) and BrachyVision ACUROS{sup TM}]. Dose comparisons were performed using state-of-the-art MC codes for radiation transport, including ALGEBRA, BrachyDose, GEANT4, MCNP5, MCNP6, and PENELOPE2008. The methodologies adhered to recommendations in the AAPM TG-229 report on high-energy brachytherapy source dosimetry. TG-43 dosimetry parameters, an along-away dose-rate table, and primary and scatter separated (PSS) data were obtained. The virtual water phantom of (201){sup 3} voxels (1 mm sides) was used to evaluate the calculated dose distributions. Two test case plans involving a single position of the generic HDR {sup 192}Ir source in this phantom were prepared: (i) source centered in the phantom and (ii) source displaced 7 cm laterally from the center. Datasets were independently produced by

  3. Generic Software Architecture for Launchers

    Science.gov (United States)

    Carre, Emilien; Gast, Philippe; Hiron, Emmanuel; Leblanc, Alain; Lesens, David; Mescam, Emmanuelle; Moro, Pierre

    2015-09-01

    The definition and reuse of generic software architecture for launchers is not so usual for several reasons: the number of European launcher families is very small (Ariane 5 and Vega for these last decades); the real time constraints (reactivity and determinism needs) are very hard; low levels of versatility are required (implying often an ad hoc development of the launcher mission). In comparison, satellites are often built on a generic platform made up of reusable hardware building blocks (processors, star-trackers, gyroscopes, etc.) and reusable software building blocks (middleware, TM/TC, On Board Control Procedure, etc.). If some of these reasons are still valid (e.g. the limited number of development), the increase of the available CPU power makes today an approach based on a generic time triggered middleware (ensuring the full determinism of the system) and a centralised mission and vehicle management (offering more flexibility in the design and facilitating the long term maintenance) achievable. This paper presents an example of generic software architecture which could be envisaged for future launchers, based on the previously described principles and supported by model driven engineering and automatic code generation.

  4. The electric field distributions in anatomical head models during transcranial direct current stimulation for post-stroke rehabilitation.

    Science.gov (United States)

    Manoli, Zoi; Parazzini, Marta; Ravazzani, Paolo; Samaras, Theodoros

    2017-01-01

    The lack of knowledge of the electric field distribution inside the brain of stroke patients receiving transcranial direct current stimulation (tDCS) calls for estimating it computationally. Moreover, the impact on this distribution of a novel clinical management approach which involves secondary motor areas (SMA) in stroke rehabilitation needs to be evaluated. Finally, the differences in the electric field distributions due to gender and age need to be investigated. This work presents the development of two different anatomical models (young adult female and elderly male) with an ischemic stroke region of spherical volume 10 cm(3) or 50 cm(3) , using numerical models of the Virtual Population (ViP). The stroke phase was considered as acute or chronic, resulting in different electrical properties of the area. Two different electrode montages were used - One over the lesion area and the contralateral supra-orbital region and the other over the SMA and the contralateral supra-orbital region. A quasi-electrostatic solver was used to numerically solve the Laplace equation with the finite-difference technique. Both the 99th percentile of the electric field intensity distribution ("E peak value") and the percentage of the tissue volumes with electric field intensity over 50% and 70% of the E peak value were assessed inside the target areas of the primary motor cortex (M1) and the SMA, as well as in other brain tissues (hypothalamus and cerebellum). In the acute phase of an ischemic stroke, the normalized electric field intensity distributions do not differ noticeably compared to those in the brain of a healthy person (mean square difference electric field in the tissues in the SMA are almost equal for both electrode montages. The peak values of the electric field distribution ("E peak values") in cerebellum and hypothalamus for both electrode montages are rather small but different from those of healthy patients. The largest difference of 21% decrease with respect to a

  5. Explicit Compact Surface-Potential and Drain-Current Models for Generic Asymmetric Double-Gate Metal-Oxide-Semiconductor Field-Effect Transistors

    Science.gov (United States)

    Zhu, Zhaomin; Zhou, Xing; Chandrasekaran, Karthik; Rustagi, Subhash C.; See, Guan Huei

    2007-04-01

    In this paper, explicit surface potentials for undoped asymmetric-double-gate (a-DG) metal-oxide-semiconductor field-effect transistors (MOSFETs) suitable for compact model development are presented for the first time. The model is physically derived from Poisson’s equation in each region of operation and adopted in a unified regional approach. The proposed model is physically scalable with oxide/channel thicknesses and has been verified with generic implicit solutions for independent gate biases as well as for different gate/oxide materials. The model is extendable to silicon-on-insulator (SOI) and symmetric-DG (s-DG) MOSFETs. Finally, a continuous, explicit drain-current equation has been derived on the basis of the developed explicit surface-potential solutions.

  6. Development and validation of a generic finite element vehicle buck model for the analysis of driver rib fractures in real life nearside oblique frontal crashes.

    Science.gov (United States)

    Iraeus, Johan; Lindquist, Mats

    2016-10-01

    Frontal crashes still account for approximately half of all fatalities in passenger cars, despite several decades of crash-related research. For serious injuries in this crash mode, several authors have listed the thorax as the most important. Computer simulation provides an effective tool to study crashes and evaluate injury mechanisms, and using stochastic input data, whole populations of crashes can be studied. The aim of this study was to develop a generic buck model and to validate this model on a population of real-life frontal crashes in terms of the risk of rib fracture. The study was conducted in four phases. In the first phase, real-life validation data were derived by analyzing NASS/CDS data to find the relationship between injury risk and crash parameters. In addition, available statistical distributions for the parameters were collected. In the second phase, a generic parameterized finite element (FE) model of a vehicle interior was developed based on laser scans from the A2MAC1 database. In the third phase, model parameters that could not be found in the literature were estimated using reverse engineering based on NCAP tests. Finally, in the fourth phase, the stochastic FE model was used to simulate a population of real-life crashes, and the result was compared to the validation data from phase one. The stochastic FE simulation model overestimates the risk of rib fracture, more for young occupants and less for senior occupants. However, if the effect of underestimation of rib fractures in the NASS/CDS material is accounted for using statistical simulations, the risk of rib fracture based on the stochastic FE model matches the risk based on the NASS/CDS data for senior occupants. The current version of the stochastic model can be used to evaluate new safety measures using a population of frontal crashes for senior occupants. Copyright © 2016 Elsevier Ltd. All rights reserved.

  7. Generic process design and control strategies used to develop a dynamic model and training software for an IGCC plant with CO2 sequestration

    Energy Technology Data Exchange (ETDEWEB)

    Provost, G.; Stone, H.; McClintock, M.; Erbes, M.; Zitney, S.; Turton, R.; Phillips, J.; Quintrell, M.; Marasigan, J.

    2008-01-01

    To meet the growing demand for education and experience with the analysis, operation, and control of commercial-scale Integrated Gasification Combined Cycle (IGCC) plants, the Department of Energy’s (DOE) National Energy Technology Laboratory (NETL) is leading a collaborative R&D project with participants from government, academia, and industry. One of the goals of this project is to develop a generic, full-scope, real-time generic IGCC dynamic plant simulator for use in establishing a world-class research and training center, as well as to promote and demonstrate the technology to power industry personnel. The NETL IGCC dynamic plant simulator will combine for the first time a process/gasification simulator and a power/combined-cycle simulator together in a single dynamic simulation framework for use in training applications as well as engineering studies. As envisioned, the simulator will have the following features and capabilities: A high-fidelity, real-time, dynamic model of process-side (gasification and gas cleaning with CO2 capture) and power-block-side (combined cycle) for a generic IGCC plant fueled by coal and/or petroleum coke Full-scope training simulator capabilities including startup, shutdown, load following and shedding, response to fuel and ambient condition variations, control strategy analysis (turbine vs. gasifier lead, etc.), representative malfunctions/trips, alarms, scenarios, trending, snapshots, data historian, and trainee performance monitoring The ability to enhance and modify the plant model to facilitate studies of changes in plant configuration and equipment and to support future R&D efforts To support this effort, process descriptions and control strategies were developed for key sections of the plant as part of the detailed functional specification, which will form the basis of the simulator development. These plant sections include: Slurry Preparation Air Separation Unit Gasifiers Syngas Scrubbers Shift Reactors Gas Cooling

  8. The Fate of Anatomical Collections

    NARCIS (Netherlands)

    Knoeff, Rina; Zwijnenberg, Robert

    2015-01-01

    Almost every medical faculty possesses anatomical and/or pathological collections: human and animal preparations, wax- and other models, as well as drawings, photographs, documents and archives relating to them. In many institutions these collections are well-preserved, but in others they are poorly

  9. A Generic Dynamic Emulator

    CERN Document Server

    Albert, Carlo

    2011-01-01

    In applied sciences, we often deal with deterministic simulation models that are too slow for simulation-intensive tasks such as calibration or real-time control. In this paper, an emulator for a generic dynamic model, given by a system of ordinary non-linear differential equations, is developed. The non-linear differential equations are linearized and Gaussian white noise is added to account for the non-linearities. The resulting linear stochastic system is conditioned on a set of solutions of the non-linear equations that have been calculated prior to the emulation. A path-integral approach is used to derive the Gaussian distribution of the emulated solution. The solution reveals that most of the computational burden can be shifted to the conditioning phase of the emulator and the complexity of the actual emulation step only scales like $\\mathcal O(Nnm^2)$, where $N$ is the number of time-points at which the solution is to be emulated, $n$ the number of solutions the emulator is conditioned on and $m$ the n...

  10. Practicing the Generic (City)

    DEFF Research Database (Denmark)

    Hansen, Lone Koefoed

    2010-01-01

    Flanagan proposes that most locative media artworks neglect the particularities of spaces, their historical and political layers. Koolhaas, on the other hand, states that all urban areas are alike, that we are facing a global Generic City. The paper analyses digital media artist Esther Polak......’s NomadicMILK project in light of the generic and particular properties of space as laid out by Flanagan and Koolhaas in order to discuss the possible reconfiguring practices of locative media....

  11. Generic substitution, financial interests, and imperfect agency.

    Science.gov (United States)

    Rischatsch, Maurus; Trottmann, Maria; Zweifel, Peter

    2013-06-01

    Policy makers around the world seek to encourage generic substitution. In this paper, the importance of prescribing physicians' imperfect agency is tested using the fact that some Swiss jurisdictions allow physicians to dispense drugs on their own account (physician dispensing, PD) while others disallow it. We estimate a model of physician drug choice with the help of drug claim data, finding a significant positive association between PD and the use of generics. While this points to imperfect agency, generics are prescribed more often to patients with high copayments or low incomes.

  12. Assessment of the Orion-SLS Interface Management Process in Achieving the EIA 731.1 Systems Engineering Capability Model Generic Practices Level 3 Criteria

    Science.gov (United States)

    Jellicorse, John J.; Rahman, Shamin A.

    2016-01-01

    NASA is currently developing the next generation crewed spacecraft and launch vehicle for exploration beyond earth orbit including returning to the Moon and making the transit to Mars. Managing the design integration of major hardware elements of a space transportation system is critical for overcoming both the technical and programmatic challenges in taking a complex system from concept to space operations. An established method of accomplishing this is formal interface management. In this paper we set forth an argument that the interface management process implemented by NASA between the Orion Multi-Purpose Crew Vehicle (MPCV) and the Space Launch System (SLS) achieves the Level 3 tier of the EIA 731.1 System Engineering Capability Model (SECM) for Generic Practices. We describe the relevant NASA systems and associated organizations, and define the EIA SECM Level 3 Generic Practices. We then provide evidence for our compliance with those practices. This evidence includes discussions of: NASA Systems Engineering Interface (SE) Management standard process and best practices; the tailoring of that process for implementation on the Orion to SLS interface; changes made over time to improve the tailored process, and; the opportunities to take the resulting lessons learned and propose improvements to our institutional processes and best practices. We compare this evidence against the practices to form the rationale for the declared SECM maturity level.

  13. Monte Carlo model for a prototype CT-compatible, anatomically adaptive, shielded intracavitary brachytherapy applicator for the treatment of cervical cancer

    Energy Technology Data Exchange (ETDEWEB)

    Price, Michael J.; Gifford, Kent A.; Horton, John L. Jr.; Eifel, Patricia J.; Gillin, Michael T.; Lawyer, Ann A.; Mourtada, Firas [Department of Radiation Physics, University of Texas M. D. Anderson Cancer Center, 1220 Holcombe Boulevard, Houston, Texas 77030 and Graduate School of Biomedical Sciences, University of Texas-Houston, 6767 Bertner Avenue, Houston, Texas 77030 (United States); Department of Radiation Physics, University of Texas M. D. Anderson Cancer Center, 1220 Holcombe Boulevard, Houston, Texas 77030 (United States); Division of Radiation Oncology, University of Texas M. D. Anderson Cancer Center, 1220 Holcombe Boulevard, Houston, Texas 77030 and Graduate School of Biomedical Sciences, University of Texas-Houston, 6767 Bertner Avenue, Houston, Texas 77030 (United States); Department of Radiation Physics, University of Texas M. D. Anderson Cancer Center, 1220 Holcombe Boulevard, Houston, Texas 77030 and Graduate School of Biomedical Sciences, University of Texas-Houston, 6767 Bertner Avenue, Houston, Texas 77030 (United States); Department of Radiation Physics, University of Texas M. D. Anderson Cancer Center, 1220 Holcombe Boulevard, Houston, Texas 77030 (United States); Department of Radiation Physics, University of Texas M. D. Anderson Cancer Center, 1220 Holcombe Boulevard, Houston, Texas 77030 and Graduate School of Biomedical Sciences, University of Texas-Houston, 6767 Bertner Avenue, Houston, Texas 77030 (United States)

    2009-09-15

    Purpose: Current, clinically applicable intracavitary brachytherapy applicators that utilize shielded ovoids contain a pair of tungsten-alloy shields which serve to reduce dose delivered to the rectum and bladder during source afterloading. After applicator insertion, these fixed shields are not necessarily positioned to provide optimal shielding of these critical structures due to variations in patient anatomies. The authors present a dosimetric evaluation of a novel prototype intracavitary brachytherapy ovoid [anatomically adaptive applicator (A{sup 3})], featuring a single shield whose position can be adjusted with two degrees of freedom: Rotation about and translation along the long axis of the ovoid. Methods: The dosimetry of the device for a HDR {sup 192}Ir was characterized using radiochromic film measurements for various shield orientations. A MCNPX Monte Carlo model was developed of the prototype ovoid and integrated with a previously validated model of a v2 mHDR {sup 192}Ir source (Nucletron Co.). The model was validated for three distinct shield orientations using film measurements. Results: For the most complex case, 91% of the absolute simulated and measured dose points agreed within 2% or 2 mm and 96% agreed within 10% or 2 mm. Conclusions: Validation of the Monte Carlo model facilitates future investigations into any dosimetric advantages the use of the A{sup 3} may have over the current state of art with respect to optimization and customization of dose delivery as a function of patient anatomical geometries.

  14. Generic Dynamic Scaling in Kinetic Roughening

    OpenAIRE

    Ramasco, José J.; López, Juan M.; Rodríguez, Miguel A.

    2000-01-01

    We study the dynamic scaling hypothesis in invariant surface growth. We show that the existence of power-law scaling of the correlation functions (scale invariance) does not determine a unique dynamic scaling form of the correlation functions, which leads to the different anomalous forms of scaling recently observed in growth models. We derive all the existing forms of anomalous dynamic scaling from a new generic scaling ansatz. The different scaling forms are subclasses of this generic scali...

  15. On Phases of Generic Toric Singularities

    CERN Document Server

    Sarkar, Tapobrata

    2007-01-01

    We systematically study the phases of generic toric singularities, using methods initiated in hep-th/0612046. These correspond to Gauged Linear Sigma Models with arbitrary charges. We show that complete information about generic $U(1)^r$ GLSMs can be obtained by studying the GLSM Lagrangian, appropriately modified in the different phases of the theory. This can be used to study the different phases of $L^{a,b,c}$ spaces and their non-supersymmetric counterparts.

  16. Modeling of irradiated graphite (14)C transfer through engineered barriers of a generic geological repository in crystalline rocks.

    Science.gov (United States)

    Poskas, Povilas; Grigaliuniene, Dalia; Narkuniene, Asta; Kilda, Raimondas; Justinavicius, Darius

    2016-11-01

    There are two RBMK-1500 type graphite moderated reactors at the Ignalina nuclear power plant in Lithuania, and they are under decommissioning now. The graphite cannot be disposed of in a near surface repository, because of large amounts of (14)C. Therefore, disposal of the graphite in a geological repository is a reasonable solution. This study presents evaluation of the (14)C transfer by the groundwater pathway into the geosphere from the irradiated graphite in a generic geological repository in crystalline rocks and demonstration of the role of the different components of the engineered barrier system by performing local sensitivity analysis. The speciation of the released (14)C into organic and inorganic compounds as well as the most recent information on (14)C source term was taken into account. Two alternatives were considered in the analysis: disposal of graphite in containers with encapsulant and without it. It was evaluated that the maximal fractional flux of inorganic (14)C into the geosphere can vary from 10(-11)y(-1) (for non-encapsulated graphite) to 10(-12)y(-1) (for encapsulated graphite) while of organic (14)C it was about 10(-3)y(-1) of its inventory. Such difference demonstrates that investigations on the (14)C inventory and chemical form in which it is released are especially important. The parameter with the highest influence on the maximal flux into the geosphere for inorganic (14)C transfer was the sorption coefficient in the backfill and for organic (14)C transfer - the backfill hydraulic conductivity.

  17. FRAUD/SABOTAGE Killing Nuclear-Reactors Need Modeling!!!: ``Super'' alloys GENERIC ENDEMIC Wigner's-Disease/.../IN-stability: Ethics? SHMETHICS!!!

    Science.gov (United States)

    O'Grady, Joseph; Bument, Arlden; Siegel, Edward

    2011-03-01

    Carbides solid-state chemistry domination of old/new nuclear-reactors/spent-fuel-casks/refineries/jet/missile/rocket-engines is austenitic/FCC Ni/Fe-based (so miscalled)"super"alloys(182/82;Hastelloy-X,600,304/304L-SSs,...690!!!) GENERIC ENDEMIC EXTANT detrimental(synonyms): Wigner's-disease(WD) [J.Appl.Phys.17,857 (46)]/Ostwald-ripening/spinodal-decomposition/overageing-embrittlement/thermal-leading-to-mechanical(TLTM)-INstability: Mayo[Google: fLeaksCouldKill > ; - Siegel [ J . Mag . Mag . Mtls . 7 , 312 (78) = atflickr . comsearchonGiant - Magnotoresistance [Fert" [PRL(1988)]-"Gruenberg"[PRL(1989)] 2007-Nobel]necessitating NRC inspections on 40+25=65 Westin"KL"ouse PWRs(12/2006)]-Lai [Met.Trans.AIME, 9A,827(78)]-Sabol-Stickler[Phys.Stat.Sol.(70)]-Ashpahani[ Intl.Conf. Hydrogen in Metals, Paris(1977]-Russell [Prog.Mtls.Sci.(1983)]-Pollard [last UCS rept.(9/1995)]-Lofaro [BNL/DOE/NRC Repts.]-Pringle [ Nuclear-Power:From Physics to Politics(1979)]-Hoffman [animatedsoftware.com], what DOE/NRC MISlabels as "butt-welds" "stress-corrosion cracking" endpoint's ROOT-CAUSE ULTIMATE-ORIGIN is WD overageing-embrittlement caused brittle-fracture cracking from early/ongoing AEC/DOE-n"u"tional-la"v"atories sabotage!!!

  18. Application of Porter’s Five Forces Model and generic strategies for vascular surgery: should be stuck in the middle?

    Science.gov (United States)

    Sumpio, Bauer E

    2013-06-01

    There are many stakeholders in the vascular marketplace from clinicians to hospitals, third party payers, medical device manufacturers and the government. Economic stress, threats of policy reform and changing health-care delivery are adding to the challenges faced by vascular surgeons. Use of Porter's Five Forces analysis to identify the sources of competition, the strength and likelihood of that competition existing, and barriers to competition that affect vascular surgery will help our specialty understand both the strength of our current competition and the strength of a position that our specialty will need to move to. By understanding the nature of the Porter's Five Forces as it applies to vascular surgery, and by appreciating their relative importance, our society would be in a stronger position to defend itself against threats and perhaps influence the forces with a long-term strategy. Porter's generic strategies attempt to create effective links for business with customers and suppliers and create barriers to new entrants and substitute products. It brings an initial perspective that is convenient to adapt to vascular surgery in order to reveal opportunities.Vascular surgery is uniquely situated to pursue both a differentiation and high value leadership strategy.

  19. Slice-based supine to standing postured deformation for Chinese anatomical models and the dosimetric results by wide band frequency electromagnetic field exposure: morphing.

    Science.gov (United States)

    Wu, Tongning; Tan, Liwen; Shao, Qing; Li, Ying; Yang, Lei; Zhao, Chen; Xie, Yi; Zhang, Shaoxiang

    2013-04-01

    Digital human models are frequently obtained from supine-postured medical images or cadaver slices, but many applications require standing models. This paper presents the work of reconstructing standing Chinese adult anatomical models from supine postured slices. Apart from the previous studies, the deformation works on 2-D segmented slices. The surface profile of the standing posture is adjusted by population measurement data. A non-uniform texture amplification approach is applied on the 2-D slices to recover the skin contour and to redistribute the internal tissues. Internal organ shift due to postures is taken into account. The feet are modified by matrix rotation. Then, the supine and standing models are utilised for the evaluation of electromagnetic field exposure over wide band frequency and different incident directions.

  20. Anatomical education and surgical simulation based on the Chinese Visible Human: a three-dimensional virtual model of the larynx region.

    Science.gov (United States)

    Liu, Kaijun; Fang, Binji; Wu, Yi; Li, Ying; Jin, Jun; Tan, Liwen; Zhang, Shaoxiang

    2013-09-01

    Anatomical knowledge of the larynx region is critical for understanding laryngeal disease and performing required interventions. Virtual reality is a useful method for surgical education and simulation. Here, we assembled segmented cross-section slices of the larynx region from the Chinese Visible Human dataset. The laryngeal structures were precisely segmented manually as 2D images, then reconstructed and displayed as 3D images in the virtual reality Dextrobeam system. Using visualization and interaction with the virtual reality modeling language model, a digital laryngeal anatomy instruction was constructed using HTML and JavaScript languages. The volume larynx models can thus display an arbitrary section of the model and provide a virtual dissection function. This networked teaching system of the digital laryngeal anatomy can be read remotely, displayed locally, and manipulated interactively.

  1. A new top boundary condition for modeling surface diffusive exchange of a generic volatile tracer: theoretical analysis and application to soil evaporation

    Directory of Open Access Journals (Sweden)

    J. Y. Tang

    2013-02-01

    Full Text Available We describe a new top boundary condition (TBC for representing the air–soil diffusive exchange of a generic volatile tracer. This new TBC (1 accounts for the multi-phase flow of a generic tracer; (2 accounts for effects of soil temperature, pH, solubility, sorption, and desorption processes; (3 enables a smooth transition between wet and dry soil conditions; (4 is compatible with the conductance formulation for modeling air–water volatile tracer exchange; and (5 is applicable to site, regional, and global land models.

    Based on the new TBC, we developed new formulations for bare-soil resistance and corresponding soil evaporation efficiency. The new soil resistance is predicted as the reciprocal of the harmonic sum of two resistances: (1 gaseous and aqueous molecular diffusion and (2 liquid mass flow resulting from the hydraulic pressure gradient between the soil surface and center of the topsoil control volume. We compared the predicted soil evaporation efficiency with those from several field and laboratory soil evaporation measurements and found good agreement with the typically observed two-stage soil evaporation curves. Comparison with the soil evaporation efficiency equation of Lee and Pielke (1992; hereafter LP92 indicates that their equation can overestimate soil evaporation when the atmospheric resistance is low and underestimate soil evaporation when the soil is dry. Using a synthetic inversion experiment, we demonstrated that using inverted soil resistance data from field measurements to derive empirical soil resistance formulations resulted in large uncertainty because (1 the inverted soil resistance data are always severely impacted by measurement error and (2 the derived empirical equation is very sensitive to the number of data points and the assumed functional form of the resistance.

    We expect the application of our new TBC in land models will provide a consistent representation for the diffusive tracer

  2. Generic Airspace Survey

    Science.gov (United States)

    Mogford, Richard H.; Bridges, Wayne; Gujarl, Vimmy; Lee, Paul U.; Preston, William

    2013-01-01

    This paper reports on an extension of generic airspace research to explore the amount of memorization and specialized skills required to manage sectors with specific characteristics or factors. Fifty-five retired controllers were given an electronic survey where they rated the amount of memorization or specialized skills needed for sixteen generic airspace factors. The results suggested similarities in the pattern of ratings between different areas of the US (East, Central, and West). The average of the ratings for each area also showed some differences between regions, with ratings being generally higher in the East area. All sixteen factors were rated as moderately to highly important and may be useful for future research on generic airspace, air traffic controller workload, etc.

  3. Generic robot architecture

    Science.gov (United States)

    Bruemmer, David J [Idaho Falls, ID; Few, Douglas A [Idaho Falls, ID

    2010-09-21

    The present invention provides methods, computer readable media, and apparatuses for a generic robot architecture providing a framework that is easily portable to a variety of robot platforms and is configured to provide hardware abstractions, abstractions for generic robot attributes, environment abstractions, and robot behaviors. The generic robot architecture includes a hardware abstraction level and a robot abstraction level. The hardware abstraction level is configured for developing hardware abstractions that define, monitor, and control hardware modules available on a robot platform. The robot abstraction level is configured for defining robot attributes and provides a software framework for building robot behaviors from the robot attributes. Each of the robot attributes includes hardware information from at least one hardware abstraction. In addition, each robot attribute is configured to substantially isolate the robot behaviors from the at least one hardware abstraction.

  4. Generic reactive transport codes as flexible tools to integrate soil organic matter degradation models with water, transport and geochemistry in soils

    Science.gov (United States)

    Jacques, Diederik; Gérard, Fréderic; Mayer, Uli; Simunek, Jirka; Leterme, Bertrand

    2016-04-01

    A large number of organic matter degradation, CO2 transport and dissolved organic matter models have been developed during the last decades. However, organic matter degradation models are in many cases strictly hard-coded in terms of organic pools, degradation kinetics and dependency on environmental variables. The scientific input of the model user is typically limited to the adjustment of input parameters. In addition, the coupling with geochemical soil processes including aqueous speciation, pH-dependent sorption and colloid-facilitated transport are not incorporated in many of these models, strongly limiting the scope of their application. Furthermore, the most comprehensive organic matter degradation models are combined with simplified representations of flow and transport processes in the soil system. We illustrate the capability of generic reactive transport codes to overcome these shortcomings. The formulations of reactive transport codes include a physics-based continuum representation of flow and transport processes, while biogeochemical reactions can be described as equilibrium processes constrained by thermodynamic principles and/or kinetic reaction networks. The flexibility of these type of codes allows for straight-forward extension of reaction networks, permits the inclusion of new model components (e.g.: organic matter pools, rate equations, parameter dependency on environmental conditions) and in such a way facilitates an application-tailored implementation of organic matter degradation models and related processes. A numerical benchmark involving two reactive transport codes (HPx and MIN3P) demonstrates how the process-based simulation of transient variably saturated water flow (Richards equation), solute transport (advection-dispersion equation), heat transfer and diffusion in the gas phase can be combined with a flexible implementation of a soil organic matter degradation model. The benchmark includes the production of leachable organic matter

  5. A pilot study on objective quantification and anatomical modelling of in vivo head and neck positions commonly applied in training and competition of sport horses.

    Science.gov (United States)

    Elgersma, A E; Wijnberg, I D; Sleutjens, J; van der Kolk, J H; van Weeren, P R; Back, W

    2010-11-01

    Head and neck positions (HNP) in sport horses are under debate in the equine community, as they could interfere with equine welfare. HNPs have not been quantified objectively and no information is available on their head and neck loading. To quantify in vivo HNPs in sport horses and develop o a model to estimate loading on the cervical vertebrae in these positions. Videos were taken of 7 Warmbloods at walk on a straight line in 5 positions, representing all HNPs during Warmblood training and competition. Markers were glued at 5 anatomical landmarks. Two-dimensional angles and distances were determined from video frames for the 5 HNPs and statistically compared (P origin of C2 for all HNPs, except for the 'hyperextended' HNP5; the 'hyperflexed' HNP4 showed the largest loading values on the nuchal ligament origins at all locations. HNPs can be accurately quantified in the sagittal plane from angles and distances based on standard anatomical landmarks and home-video captured images. Nuchal ligament loading showed the largest estimated values at its origin on C2 in hyperflexion (HNP4). Modelling opens further perspectives to eventually estimate loading for individual horses and thus ergonomically optimise their HNP, which may improve the welfare of the sport horse during training and competition. © 2010 EVJ Ltd.

  6. Rethinking generic skills

    Directory of Open Access Journals (Sweden)

    Roy Canning

    2013-10-01

    Full Text Available The paper provides a critical analysis of the notion of generic or transversal skillscontained with European Union policy discourses. The author presents a conceptualframework that challenges the idea that generic skills are universal, transferable andautonomous. An alternative analysis is put forward that argues the case forcontextualising skills and knowledge within particular understandings and cultures thatare more collective than individualistic in nature. The arguments are framed withinwider cross-disciplinary debates in linguistics, geosemiotics and social-cultural theoryand build upon an earlier paper exploring core skills in the UK (Canning, 2007.

  7. Development of an integrated generic model for multi-scale assessment of the impacts of agro-ecosystems on major ecosystem services in West Africa.

    Science.gov (United States)

    Belem, Mahamadou; Saqalli, Mehdi

    2017-11-01

    This paper presents an integrated model assessing the impacts of climate change, agro-ecosystem and demographic transition patterns on major ecosystem services in West-Africa along a partial overview of economic aspects (poverty reduction, food self-sufficiency and income generation). The model is based on an agent-based model associated with a soil model and multi-scale spatial model. The resulting Model for West-Africa Agro-Ecosystem Integrated Assessment (MOWASIA) is ecologically generic, meaning it is designed for all sudano-sahelian environments but may then be used as an experimentation facility for testing different scenarios combining ecological and socioeconomic dimensions. A case study in Burkina Faso is examined to assess the environmental and economic performances of semi-continuous and continuous farming systems. Results show that the semi-continuous system using organic fertilizer and fallowing practices contribute better to environment preservation and food security than the more economically performant continuous system. In addition, this study showed that farmers heterogeneity could play an important role in agricultural policies planning and assessment. In addition, the results showed that MOWASIA is an effective tool for designing, analysing the impacts of agro-ecosystems. Copyright © 2017. Published by Elsevier Ltd.

  8. Modelling and simulation of low-density lipoprotein transport through multi-layered wall of an anatomically realistic carotid artery bifurcation

    Science.gov (United States)

    Kenjereš, Saša; de Loor, Alexander

    2014-01-01

    A high concentration of low-density lipoprotein (LDL) is recognized as one of the principal risk factors for development of atherosclerosis. This paper reports on modelling and simulations of the coupled mass (LDL concentration) and momentum transport through the arterial lumen and the multi-layered arterial wall of an anatomically realistic carotid bifurcation. The mathematical model includes equations for conservation of mass, momentum and concentration, which take into account a porous layer structure, the biological membranes and reactive source/sink terms in different layers of the arterial wall, as proposed in Yang & Vafai (2006). A four-layer wall model of an arterial wall with constant thickness is introduced and initially tested on a simple cylinder geometry where realistic layer properties are specified. Comparative assessment with previously published results demonstrated proper implementation of the mathematical model. Excellent agreement for the velocity and LDL concentration distributions in the arterial lumen and in the artery wall are obtained. Then, an anatomically realistic carotid artery bifurcation is studied. This is the main novelty of the presented research. We find a strong dependence between underlying blood flow pattern (and consequently the wall shear stress distributions) and the uptake of the LDL concentration in the artery wall. The radial dependency of interactions between the diffusion, convection and chemical reactions within the multi-layered artery wall is crucial for accurate predictions of the LDL concentration in the media. It is shown that a four-layer wall model produced qualitatively good agreement with the experimental results of Meyer et al. (1996) in predicting levels of LDL within the media of a rabbit aorta under identical transmural pressure conditions. Finally, it is demonstrated that the adopted model represents a good initial platform for future numerical investigations of the initial stage of atherosclerosis for

  9. Statistical prediction of seasonal discharge in Central Asia for water resources management: development of a generic (pre-)operational modeling tool

    Science.gov (United States)

    Apel, Heiko; Baimaganbetov, Azamat; Kalashnikova, Olga; Gavrilenko, Nadejda; Abdykerimova, Zharkinay; Agalhanova, Marina; Gerlitz, Lars; Unger-Shayesteh, Katy; Vorogushyn, Sergiy; Gafurov, Abror

    2017-04-01

    The semi-arid regions of Central Asia crucially depend on the water resources supplied by the mountainous areas of the Tien-Shan and Pamirs. During the summer months the snow and glacier melt dominated river discharge originating in the mountains provides the main water resource available for agricultural production, but also for storage in reservoirs for energy generation during the winter months. Thus a reliable seasonal forecast of the water resources is crucial for a sustainable management and planning of water resources. In fact, seasonal forecasts are mandatory tasks of all national hydro-meteorological services in the region. In order to support the operational seasonal forecast procedures of hydromet services, this study aims at the development of a generic tool for deriving statistical forecast models of seasonal river discharge. The generic model is kept as simple as possible in order to be driven by available hydrological and meteorological data, and be applicable for all catchments with their often limited data availability in the region. As snowmelt dominates summer runoff, the main meteorological predictors for the forecast models are monthly values of winter precipitation and temperature as recorded by climatological stations in the catchments. These data sets are accompanied by snow cover predictors derived from the operational ModSnow tool, which provides cloud free snow cover data for the selected catchments based on MODIS satellite images. In addition to the meteorological data antecedent streamflow is used as a predictor variable. This basic predictor set was further extended by multi-monthly means of the individual predictors, as well as composites of the predictors. Forecast models are derived based on these predictors as linear combinations of up to 3 or 4 predictors. A user selectable number of best models according to pre-defined performance criteria is extracted automatically by the developed model fitting algorithm, which includes a test

  10. Evaluating Generic Pantropical Allometric Models for the Estimation of Above-Ground Biomass in the Teak Plantations of Southern Western Ghats, India

    Directory of Open Access Journals (Sweden)

    S. Sandeep

    2015-09-01

    Full Text Available The use of suitable tree biomass allometric equations is crucial for making precise and non- destructive estimation of carbon storage and biomass energy values. The aim of this research was to evaluate the accuracy of the most commonly used pantropical allometric models and site-specific models to estimate the above-ground biomass (AGB in different aged teak plantations of Southern Western Ghats of India. For this purpose, the AGB data measured for 70 trees with diameter >10 cm from different aged teak plantations in Kerala part of Southern Western Ghats following destructive procedure was used. The results show that site specific models based on a single predictor variable diameter at breast height (dbh, though simple, may grossly increase the uncertainty across sites. Hence, a generic model encompassing dbh, height and wood specific gravity with sufficient calibration taking into account different forest types is advised for the tropical forest systems. The study also suggests that the commonly used pantropical models should be evaluated for different ecosystems prior to their application at national or regional scales.

  11. Exploring Generic Haskell

    NARCIS (Netherlands)

    Löh, A.

    2004-01-01

    This thesis is an exploration -- an exploration of a language extension of the functional programming language Haskell. The extension is called Generic Haskell, albeit the name has been used to refer to different objects over the last several years: Many papers have described different proposals, fe

  12. Generic Crystalline Disposal Reference Case

    Energy Technology Data Exchange (ETDEWEB)

    Painter, Scott Leroy [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Chu, Shaoping [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Harp, Dylan Robert [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Perry, Frank Vinton [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Wang, Yifeng [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2015-02-20

    A generic reference case for disposal of spent nuclear fuel and high-level radioactive waste in crystalline rock is outlined. The generic cases are intended to support development of disposal system modeling capability by establishing relevant baseline conditions and parameters. Establishment of a generic reference case requires that the emplacement concept, waste inventory, waste form, waste package, backfill/buffer properties, EBS failure scenarios, host rock properties, and biosphere be specified. The focus in this report is on those elements that are unique to crystalline disposal, especially the geosphere representation. Three emplacement concepts are suggested for further analyses: a waste packages containing 4 PWR assemblies emplaced in boreholes in the floors of tunnels (KBS-3 concept), a 12-assembly waste package emplaced in tunnels, and a 32-assembly dual purpose canister emplaced in tunnels. In addition, three failure scenarios were suggested for future use: a nominal scenario involving corrosion of the waste package in the tunnel emplacement concepts, a manufacturing defect scenario applicable to the KBS-3 concept, and a disruptive glaciation scenario applicable to both emplacement concepts. The computational approaches required to analyze EBS failure and transport processes in a crystalline rock repository are similar to those of argillite/shale, with the most significant difference being that the EBS in a crystalline rock repository will likely experience highly heterogeneous flow rates, which should be represented in the model. The computational approaches required to analyze radionuclide transport in the natural system are very different because of the highly channelized nature of fracture flow. Computational workflows tailored to crystalline rock based on discrete transport pathways extracted from discrete fracture network models are recommended.

  13. A generic TG-186 shielded applicator for commissioning model-based dose calculation algorithms for high-dose-rate (192) Ir brachytherapy.

    Science.gov (United States)

    Ma, Yunzhi; Vijande, Javier; Ballester, Facundo; Carlsson Tedgren, Åsa; Granero, Domingo; Haworth, Annette; Mourtada, Firas; Fonseca, Gabriel Paiva; Zourari, Kyveli; Papagiannis, Panagiotis; Rivard, Mark J; Siebert, Frank André; Sloboda, Ron S; Smith, Ryan; Chamberland, Marc J P; Thomson, Rowan M; Verhaegen, Frank; Beaulieu, Luc

    2017-07-19

    A joint working group was created by the American Association of Physicists in Medicine (AAPM), the European Society for Radiotherapy and Oncology (ESTRO), and the Australasian Brachytherapy Group (ABG) with the charge, among others, to develop a set of well-defined test case plans and perform model-based dose calculation algorithms (MBDCA) dose calculations and comparisons. Its main goal is to facilitate a smooth transition from the AAPM Task Group No. 43 (TG-43) dose calculation formalism, widely being used in clinical practice for brachytherapy, to the one proposed by Task Group No. 186 (TG-186) for MBDCAs. To do so, in this work a hypothetical, generic high-dose rate (HDR) (192) Ir shielded applicator has been designed and benchmarked. A generic HDR (192) Ir shielded applicator was designed based on three commercially available gynecological applicators as well as a virtual cubic water phantom that can be imported into any DICOM-RT compatible treatment planning system (TPS). The absorbed dose distribution around the applicator with the TG-186 (192) Ir source located at one dwell position at its center was computed using two commercial TPSs incorporating MBDCAs (Oncentra(®) Brachy with Advanced Collapsed-cone Engine, ACE(™) , and BrachyVision ACUROS(™) ) and state-of-the-art Monte Carlo (MC) codes, including ALGEBRA, BrachyDose, egs_brachy, Geant4, MCNP6, and Penelope2008. TPS-based volumetric dose distributions for the previously reported "source centered in water" and "source displaced" test cases, and the new "source centered in applicator" test case, were analyzed here using the MCNP6 dose distribution as a reference. Volumetric dose comparisons of TPS results against results for the other MC codes were also performed. Distributions of local and global dose difference ratios are reported. The local dose differences among MC codes are comparable to the statistical uncertainties of the reference datasets for the "source centered in water" and "source

  14. Generic behaviours in impact fragmentation

    Energy Technology Data Exchange (ETDEWEB)

    Sator, N.; Mechkov, S.; Sausset, F. [Paris-6 Univ. Pierre et Marie Curie, Lab. de Physique Theorique de la Matiere Condensee, UMR CNRS 7600, 75 - Paris (France); Mechkov, S. [Ecole Normale Superieure, Lab. de Physique Statistique, 75 - Paris (France)

    2008-02-15

    From atomic nuclei to supernovae, including plates and rocks, every cohesive system can be broken into fragments, provided that the deposited energy is sufficiently large compared to its cohesive energy. We present a simple numerical model for investigating the general properties of fragmentation. By use of molecular dynamics simulations, we study the impact fragmentation of a solid disk of interacting particles with a wall. Regardless of the particular form of the interaction potential, the fragment size distribution exhibits a power law behaviour with an exponent that increases logarithmically with the energy deposited in the system, in agreement with experiments. We expect this behaviour to be generic in fragmentation phenomena. (authors)

  15. Generic maximum likely scale selection

    DEFF Research Database (Denmark)

    Pedersen, Kim Steenstrup; Loog, Marco; Markussen, Bo

    2007-01-01

    The fundamental problem of local scale selection is addressed by means of a novel principle, which is based on maximum likelihood estimation. The principle is generally applicable to a broad variety of image models and descriptors, and provides a generic scale estimation methodology. The focus...... on second order moments of multiple measurements outputs at a fixed location. These measurements, which reflect local image structure, consist in the cases considered here of Gaussian derivatives taken at several scales and/or having different derivative orders....

  16. Assessing the forecasting performance of a generic Bio-Economic farm model calibrated with two different PMP variants

    NARCIS (Netherlands)

    Kanellopoulos, A.; Berentsen, Paul; Heckelei, T.; Ittersum, van M.K.; Oude Lansink, A.G.J.M.

    2010-01-01

    Using linear programming in bio-economic farm modelling often results in overspecialised model solutions. The positive mathematical programming (PMP) approach guarantees exact calibration to base year data but the forecasting capacity of the model is affected by necessary but arbitrary assumptions

  17. Assessing the forecasting performance of a generic Bio-Economic farm model calibrated with two different PMP variants

    NARCIS (Netherlands)

    Kanellopoulos, A.; Berentsen, Paul; Heckelei, T.; Ittersum, van M.K.; Oude Lansink, A.G.J.M.

    2010-01-01

    Using linear programming in bio-economic farm modelling often results in overspecialised model solutions. The positive mathematical programming (PMP) approach guarantees exact calibration to base year data but the forecasting capacity of the model is affected by necessary but arbitrary assumptions i

  18. Predicting the effects of ionising radiation on ecosystems by a generic model based on the Lotka-Volterra equations

    Energy Technology Data Exchange (ETDEWEB)

    Monte, Luigi [ENEA CR Casaccia, Via P. Anguillarese 301 00100 Rome (Italy)], E-mail: luigi.monte@enea.it

    2009-06-15

    The present work describes a model for predicting the population dynamics of the main components (resources and consumers) of terrestrial ecosystems exposed to ionising radiation. The ecosystem is modelled by the Lotka-Volterra equations with consumer competition. Linear dose-response relationships without threshold are assumed to relate the values of the model parameters to the dose rates. The model accounts for the migration of consumers from areas characterised by different levels of radionuclide contamination. The criteria to select the model parameter values are motivated by accounting for the results of the empirical studies of past decades. Examples of predictions for long-term chronic exposure are reported and discussed.

  19. Predicting the effects of ionising radiation on ecosystems by a generic model based on the Lotka-Volterra equations.

    Science.gov (United States)

    Monte, Luigi

    2009-06-01

    The present work describes a model for predicting the population dynamics of the main components (resources and consumers) of terrestrial ecosystems exposed to ionising radiation. The ecosystem is modelled by the Lotka-Volterra equations with consumer competition. Linear dose-response relationships without threshold are assumed to relate the values of the model parameters to the dose rates. The model accounts for the migration of consumers from areas characterised by different levels of radionuclide contamination. The criteria to select the model parameter values are motivated by accounting for the results of the empirical studies of past decades. Examples of predictions for long-term chronic exposure are reported and discussed.

  20. Using Rasch rating scale model to reassess the psychometric properties of the Persian version of the PedsQLTM 4.0 Generic Core Scales in school children

    Directory of Open Access Journals (Sweden)

    Jafari Peyman

    2012-03-01

    Full Text Available Abstract Background Item response theory (IRT is extensively used to develop adaptive instruments of health-related quality of life (HRQoL. However, each IRT model has its own function to estimate item and category parameters, and hence different results may be found using the same response categories with different IRT models. The present study used the Rasch rating scale model (RSM to examine and reassess the psychometric properties of the Persian version of the PedsQLTM 4.0 Generic Core Scales. Methods The PedsQLTM 4.0 Generic Core Scales was completed by 938 Iranian school children and their parents. Convergent, discriminant and construct validity of the instrument were assessed by classical test theory (CTT. The RSM was applied to investigate person and item reliability, item statistics and ordering of response categories. Results The CTT method showed that the scaling success rate for convergent and discriminant validity were 100% in all domains with the exception of physical health in the child self-report. Moreover, confirmatory factor analysis supported a four-factor model similar to its original version. The RSM showed that 22 out of 23 items had acceptable infit and outfit statistics (0.6, person reliabilities were low, item reliabilities were high, and item difficulty ranged from -1.01 to 0.71 and -0.68 to 0.43 for child self-report and parent proxy-report, respectively. Also the RSM showed that successive response categories for all items were not located in the expected order. Conclusions This study revealed that, in all domains, the five response categories did not perform adequately. It is not known whether this problem is a function of the meaning of the response choices in the Persian language or an artifact of a mostly healthy population that did not use the full range of the response categories. The response categories should be evaluated in further validation studies, especially in large samples of chronically ill patients.

  1. A simplified gross primary production and evapotranspiration model for boreal coniferous forests - is a generic calibration sufficient?

    Science.gov (United States)

    Minunno, F.; Peltoniemi, M.; Launiainen, S.; Aurela, M.; Lindroth, A.; Lohila, A.; Mammarella, I.; Minkkinen, K.; Mäkelä, A.

    2015-07-01

    The problem of model complexity has been lively debated in environmental sciences as well as in the forest modelling community. Simple models are less input demanding and their calibration involves a lower number of parameters, but they might be suitable only at local scale. In this work we calibrated a simplified ecosystem process model (PRELES) to data from multiple sites and we tested if PRELES can be used at regional scale to estimate the carbon and water fluxes of Boreal conifer forests. We compared a multi-site (M-S) with site-specific (S-S) calibrations. Model calibrations and evaluations were carried out by the means of the Bayesian method; Bayesian calibration (BC) and Bayesian model comparison (BMC) were used to quantify the uncertainty in model parameters and model structure. To evaluate model performances BMC results were combined with more classical analysis of model-data mismatch (M-DM). Evapotranspiration (ET) and gross primary production (GPP) measurements collected in 10 sites of Finland and Sweden were used in the study. Calibration results showed that similar estimates were obtained for the parameters at which model outputs are most sensitive. No significant differences were encountered in the predictions of the multi-site and site-specific versions of PRELES with exception of a site with agricultural history (Alkkia). Although PRELES predicted GPP better than evapotranspiration, we concluded that the model can be reliably used at regional scale to simulate carbon and water fluxes of Boreal forests. Our analyses underlined also the importance of using long and carefully collected flux datasets in model calibration. In fact, even a single site can provide model calibrations that can be applied at a wider spatial scale, since it covers a wide range of variability in climatic conditions.

  2. Generic and biosimilar medicines: quid?

    Directory of Open Access Journals (Sweden)

    Steven Simoens

    2012-12-01

    Full Text Available Once intellectual property protection, data and marketing exclusivity of reference medicines have expired, generic medicines and biosimilar medicines can enter the off-patent market. This market entry is conditional on the approval of marketing authorization, pricing and reimbursement. Given that there tends to be confusion surrounding generic and biosimilar medicines, this Editorial introduces basic concepts related to generic and biosimilar medicines and presents the different studies and articles included in this supplement dedicated to generic and biosimilar medicines.

  3. A Generic Individual-Based Spatially Explicit Model as a Novel Tool for Investigating Insect-Plant Interactions: A Case Study of the Behavioural Ecology of Frugivorous Tephritidae.

    Directory of Open Access Journals (Sweden)

    Ming Wang

    Full Text Available Computational modelling of mechanisms underlying processes in the real world can be of great value in understanding complex biological behaviours. Uptake in general biology and ecology has been rapid. However, it often requires specific data sets that are overly costly in time and resources to collect. The aim of the current study was to test whether a generic behavioural ecology model constructed using published data could give realistic outputs for individual species. An individual-based model was developed using the Pattern-Oriented Modelling (POM strategy and protocol, based on behavioural rules associated with insect movement choices. Frugivorous Tephritidae (fruit flies were chosen because of economic significance in global agriculture and the multiple published data sets available for a range of species. The Queensland fruit fly (Qfly, Bactrocera tryoni, was identified as a suitable individual species for testing. Plant canopies with modified architecture were used to run predictive simulations. A field study was then conducted to validate our model predictions on how plant architecture affects fruit flies' behaviours. Characteristics of plant architecture such as different shapes, e.g., closed-canopy and vase-shaped, affected fly movement patterns and time spent on host fruit. The number of visits to host fruit also differed between the edge and centre in closed-canopy plants. Compared to plant architecture, host fruit has less contribution to effects on flies' movement patterns. The results from this model, combined with our field study and published empirical data suggest that placing fly traps in the upper canopy at the edge should work best. Such a modelling approach allows rapid testing of ideas about organismal interactions with environmental substrates in silico rather than in vivo, to generate new perspectives. Using published data provides a saving in time and resources. Adjustments for specific questions can be achieved by

  4. Long-Term Modeling of Coupled Processes in a Generic Salt Repository for Heat-Generating Nuclear Waste: Analysis of the Impacts of Halite Solubility Constraints

    Science.gov (United States)

    Blanco Martin, L.; Rutqvist, J.; Battistelli, A.; Birkholzer, J. T.

    2015-12-01

    Rock salt is a potential medium for the underground disposal of nuclear waste because it has several assets, such as its ability to creep and heal fractures and its water and gas tightness in the undisturbed state. In this research, we focus on disposal of heat-generating nuclear waste and we consider a generic salt repository with in-drift emplacement of waste packages and crushed salt backfill. As the natural salt creeps, the crushed salt backfill gets progressively compacted and an engineered barrier system is subsequently created [1]. The safety requirements for such a repository impose that long time scales be considered, during which the integrity of the natural and engineered barriers have to be demonstrated. In order to evaluate this long-term integrity, we perform numerical modeling based on state-of-the-art knowledge. Here, we analyze the impacts of halite dissolution and precipitation within the backfill and the host rock. For this purpose, we use an enhanced equation-of-state module of TOUGH2 that properly includes temperature-dependent solubility constraints [2]. We perform coupled thermal-hydraulic-mechanical modeling and we investigate the influence of the mentioned impacts. The TOUGH-FLAC simulator, adapted for large strains and creep, is used [3]. In order to quantify the importance of salt dissolution and precipitation on the effective porosity, permeability, pore pressure, temperature and stress field, we compare numerical results that include or disregard fluids of variable salinity. The sensitivity of the results to some parameters, such as the initial saturation within the backfill, is also addressed. References: [1] Bechthold, W. et al. Backfilling and Sealing of Underground Repositories for Radioactive Waste in Salt (BAMBUS II Project). Report EUR20621 EN: European Atomic Energy Community, 2004. [2] Battistelli A. Improving the treatment of saline brines in EWASG for the simulation of hydrothermal systems. Proceedings, TOUGH Symposium 2012

  5. Analysis and prediction of agricultural pest dynamics with Tiko'n, a generic tool to develop agroecological food web models

    Science.gov (United States)

    Malard, J. J.; Rojas, M.; Adamowski, J. F.; Anandaraja, N.; Tuy, H.; Melgar-Quiñonez, H.

    2016-12-01

    While several well-validated crop growth models are currently widely used, very few crop pest models of the same caliber have been developed or applied, and pest models that take trophic interactions into account are even rarer. This may be due to several factors, including 1) the difficulty of representing complex agroecological food webs in a quantifiable model, and 2) the general belief that pesticides effectively remove insect pests from immediate concern. However, pests currently claim a substantial amount of harvests every year (and account for additional control costs), and the impact of insects and of their trophic interactions on agricultural crops cannot be ignored, especially in the context of changing climates and increasing pressures on crops across the globe. Unfortunately, most integrated pest management frameworks rely on very simple models (if at all), and most examples of successful agroecological management remain more anecdotal than scientifically replicable. In light of this, there is a need for validated and robust agroecological food web models that allow users to predict the response of these webs to changes in management, crops or climate, both in order to predict future pest problems under a changing climate as well as to develop effective integrated management plans. Here we present Tiko'n, a Python-based software whose API allows users to rapidly build and validate trophic web agroecological models that predict pest dynamics in the field. The programme uses a Bayesian inference approach to calibrate the models according to field data, allowing for the reuse of literature data from various sources and reducing the need for extensive field data collection. We apply the model to the cononut black-headed caterpillar (Opisina arenosella) and associated parasitoid data from Sri Lanka, showing how the modeling framework can be used to rapidly develop, calibrate and validate models that elucidate how the internal structures of food webs

  6. Correction of dental artifacts within the anatomical surface in PET/MRI using Active Shape Models and k-Nearest-Neighbors

    DEFF Research Database (Denmark)

    Ladefoged, Claes N.; Andersen, Flemming L.; Keller, Sune H.;

    2014-01-01

    n combined PET/MR, attenuation correction (AC) is performed indirectly based on the available MR image information. Metal implant-induced susceptibility artifacts and subsequent signal voids challenge MR-based AC. Several papers acknowledge the problem in PET attenuation correction when dental...... artifacts are ignored, but none of them attempts to solve the problem. We propose a clinically feasible correction method which combines Active Shape Models (ASM) and k- Nearest-Neighbors (kNN) into a simple approach which finds and corrects the dental artifacts within the surface boundaries of the patient...... vector, and fill the artifact voxels with a value representing soft tissue. We tested the method using fourteen patients without artifacts, and eighteen patients with dental artifacts of varying sizes within the anatomical surface of the head/neck region. Though the method wrongly filled a small volume...

  7. Generic wormhole throats

    CERN Document Server

    Visser, M; Visser, Matt; Hochberg, David

    1997-01-01

    Wormholes and black holes have traditionally been treated a quite separate objects with relatively little overlap. The possibility of a connection arises in that wormholes, if they exist, might have profound influence on black holes, their event horizons, and their internal structure. After discussing some connections, we embark on an overview of what can generally be said about traversable wormhole throats. We discuss the violations of the energy conditions that typically occur at and near the throat of any traversable wormhole and emphasize the generic nature of this result. We discuss the original Morris-Thorne wormhole and its generalization to a spherically symmetric time-dependent wormhole, and also discuss spherically symmetric Brans-Dicke wormholes. We also discuss the relationship with the topological censorship theorem. Finally we turn to a rather general class of wormholes that permit explicit analysis: generic static traversable wormholes (without any symmetry). We define the wormhole throat in te...

  8. Generic Network Location Service

    Directory of Open Access Journals (Sweden)

    Laban Mwansa

    2010-11-01

    Full Text Available This work presents the Generic Network Location Service based on the Chord implementation utilizing data structures called distributed hash tables (DHT or structured overlay networks, which are used to build scalable self-managing distributed systems. The provided algorithms guarantee resilience in the presence of dynamism: they guarantee consistent lookup results in the presence of nodes failing and leaving. Generic Network Location Service provides a Location Service system based on DHT technology, which is storing device location records in nodes within a Chord DHT. Location records are consisting of network device identification keys as attributes, which are used to create replicas of additional location records through established Chord hashing mechanisms. Storing device location records, in places address-able (using the DHT lookup by individual location record keys provides a simple way of implementing transla¬tion functions similar to well¬ known network services (e.g. ARP, DNS, ENUM. The generic network location ser¬vice presented in the paper is not supposed to be a substitu¬tion of the existing translation techniques (e.g. ARP, DNS, ENUM, but it is considered as an overlay service that uses data available in existing systems and provides some translations currently unavailable.

  9. Structural and micro-anatomical changes in vertebrae associated with idiopathic-type spinal curvature in the curveback guppy model

    Directory of Open Access Journals (Sweden)

    Wallis Rob

    2010-06-01

    Full Text Available Abstract Background The curveback lineage of guppy is characterized by heritable idiopathic-type spinal curvature that develops during growth. Prior work has revealed several important developmental similarities to the human idiopathic scoliosis (IS syndrome. In this study we investigate structural and histological aspects of the vertebrae that are associated with spinal curvature in the curveback guppy and test for sexual dimorphism that might explain a female bias for severe curve magnitudes in the population. Methods Vertebrae were studied from whole-mount skeletal specimens of curved and non-curved adult males and females. A series of ratios were used to characterize structural aspects of each vertebra. A three-way analysis of variance tested for effects of sex, curvature, vertebral position along the spine, and all 2-way interactions (i.e., sex and curvature, sex and vertebra position, and vertebra position and curvature. Histological analyses were used to characterize micro-architectural changes in affected vertebrae and the intervertebral region. Results In curveback, vertebrae that are associated with curvature demonstrate asymmetric shape distortion, migration of the intervertebral ligament, and vertebral thickening on the concave side of curvature. There is sexual dimorphism among curved individuals such that for several vertebrae, females have more slender vertebrae than do males. Also, in the region of the spine where lordosis typically occurs, curved and non-curved females have a reduced width at the middle of their vertebrae, relative to males. Conclusions Based on similarities to human spinal curvatures and to animals with induced curves, the concave-convex biases described in the guppy suggest that there is a mechanical component to curve pathogenesis in curveback. Because idiopathic-type curvature in curveback is primarily a sagittal deformity, it is structurally more similar to Scheuermann kyphosis than IS. Anatomical

  10. Item analysis using Rasch models confirms that the Danish versions of the DISABKIDS (R) chronic-generic and diabetes-specific modules are valid and reliable

    DEFF Research Database (Denmark)

    Nielsen, Julie Bøjstrup; Kyvsgaard, Julie Nyholm; Sildorf, Stine Møller

    2017-01-01

    Background: Type 1 Diabetes (T1D) has a negative impact on psychological and overall well-being. Screening for Health-related Quality of Life (HrQoL) and addressing HrQoL issues in the clinic leads to improved well-being and metabolic outcomes. The aim of this study was to translate the generic...... with T1D and were aged between 8 and 18 years old. The Rasch and the graphical log linear Rasch model (GLLRM) were used to determine validity. Monte Carlo methods and Cronbach’s α were used to confirm reliability. Results: The data did not fit a pure Rasch model but did fit a GLLRM when item six...... in the independence scale is excluded. The six subscales measure different aspects of HrQoL indicating that all the subscales are necessary. The questionnaire shows local dependency between items and differential item functioning (DIF). Therefore age, gender, and glycated hemoglobin (HbA1c) levels must be taken...

  11. CLEAR (Calculates Logical Evacuation And Response): A Generic Transportation Network Model for the Calculation of Evacuation Time Estimates

    Energy Technology Data Exchange (ETDEWEB)

    Moeller, M. P.; Urbanik, II, T.; Desrosiers, A. E.

    1982-03-01

    This paper describes the methodology and application of the computer model CLEAR (Calculates Logical Evacuation And Response) which estimates the time required for a specific population density and distribution to evacuate an area using a specific transportation network. The CLEAR model simulates vehicle departure and movement on a transportation network according to the conditions and consequences of traffic flow. These include handling vehicles at intersecting road segments, calculating the velocity of travel on a road segment as a function of its vehicle density, and accounting for the delay of vehicles in traffic queues. The program also models the distribution of times required by individuals to prepare for an evacuation. In order to test its accuracy, the CLEAR model was used to estimate evacuatlon tlmes for the emergency planning zone surrounding the Beaver Valley Nuclear Power Plant. The Beaver Valley site was selected because evacuation time estimates had previously been prepared by the licensee, Duquesne Light, as well as by the Federal Emergency Management Agency and the Pennsylvania Emergency Management Agency. A lack of documentation prevented a detailed comparison of the estimates based on the CLEAR model and those obtained by Duquesne Light. However, the CLEAR model results compared favorably with the estimates prepared by the other two agencies.

  12. Simple generic model for dynamic experiments with Saccharomyces cerevisiae in continuous culture. Decoupling between anabolism and catabolism

    DEFF Research Database (Denmark)

    Duboc, Philippe Jean; von Stockar, U.; Villadsen, John

    1998-01-01

    The dynamic behavior of a continuous culture of Saccharomyces cerevisiae subjected to a sudden increase in the dilution rate has been successfully modelled for anaerobic growth on glucose, and for aerobic growth on acetate, on ethanol, and on glucose. The catabolism responded by an immediate jump...... whereas biosynthesis did not. Thus catabolism was in excess to anabolism. The model considers the decoupling between biosynthesis and catabolism, both types of reactions being modelled by first-order kinetic expressions evolving towards maximal values. Yield parameters and maximal reaction rates were...... identified in steady state continuous cultures or during batch experiments. Only the time constant of biosynthesis regeneration, tau(x), and the time constant of catabolic capacity regeneration, tau(cat), had to be identified during transient experiments. In most experiments 7, was around 3 h, and tau...

  13. Soft Tissue Structure Modelling for Use in Orthopaedic Applications and Musculoskeletal Biomechanics

    Directory of Open Access Journals (Sweden)

    E. A. Audenaert

    2010-01-01

    Full Text Available We present our methodology for the three-dimensional anatomical and geometrical description of soft tissues, relevant for orthopaedic surgical applications and musculoskeletal biomechanics. The technique involves the segmentation and geometrical description of muscles and neurovascular structures from high-resolution computer tomography scanning for the reconstruction of generic anatomical models. These models can be used for quantitative interpretation of anatomical and biomechanical aspects of different soft tissue structures. This approach should allow the use of these data in other application fields, such as musculoskeletal modelling, simulations for radiation therapy, and databases for use in minimally invasive, navigated and robotic surgery.

  14. A generic method for evaluating crowding in the emergency department

    DEFF Research Database (Denmark)

    Eiset, Andreas Halgreen; Erlandsen, Mogens; Møllekær, Anders Brøns;

    2016-01-01

    Background Crowding in the emergency department (ED) has been studied intensively using complicated non-generic methods that may prove difficult to implement in a clinical setting. This study sought to develop a generic method to describe and analyse crowding from measurements readily available......, a ‘carry over’ effect was shown between shifts and days. Conclusions The presented method offers an easy and generic way to get detailed insight into the dynamics of crowding in an ED. Keywords Crowding, Emergency department, ED, Generic, Method, Model, Queue, Patient flow...

  15. Frequency domain reduced order model of aligned-spin effective-one-body waveforms with generic mass ratios and spins

    Science.gov (United States)

    Pürrer, Michael

    2016-03-01

    I provide a frequency domain reduced order model (ROM) for the aligned-spin effective-one-body model "SEOBNRv2" for data analysis with second- and third-generation ground-based gravitational wave (GW) detectors. SEOBNRv2 models the dominant mode of the GWs emitted by the coalescence of black hole binaries. The large physical parameter space (dimensionless spins -1 ≤χi≤0.99 and symmetric mass ratios 0.01 ≤η ≤0.25 ) requires sophisticated reduced order modeling techniques, including patching in the parameter space and in frequency. I find that the time window over which the inspiral-plunge and the merger-ringdown waveform in SEOBNRv2 are connected has a discontinuous dependence on the parameters when the spin parameter χ =0.8 or the symmetric mass ratio η ˜0.083 . This discontinuity increases resolution requirements for the ROM. The ROM can be used for compact binary systems with total masses of 2 M⊙ or higher for the Advanced LIGO design sensitivity and a 10 Hz lower cutoff frequency. The ROM has a worst mismatch against SEOBNRv2 of ˜1 %, but in general mismatches are better than ˜0.1 %. The ROM is crucial for key data analysis applications for compact binaries, such as GW searches and parameter estimation carried out within the LIGO Scientific Collaboration.

  16. Correction of dental artifacts within the anatomical surface in PET/MRI using active shape models and k-nearest-neighbors

    Science.gov (United States)

    Ladefoged, Claes N.; Andersen, Flemming L.; Keller, Sune H.; Beyer, Thomas; Højgaard, Liselotte; Lauze, François

    2014-03-01

    In combined PET/MR, attenuation correction (AC) is performed indirectly based on the available MR image information. Metal implant-induced susceptibility artifacts and subsequent signal voids challenge MR-based AC. Several papers acknowledge the problem in PET attenuation correction when dental artifacts are ignored, but none of them attempts to solve the problem. We propose a clinically feasible correction method which combines Active Shape Models (ASM) and k- Nearest-Neighbors (kNN) into a simple approach which finds and corrects the dental artifacts within the surface boundaries of the patient anatomy. ASM is used to locate a number of landmarks in the T1-weighted MR-image of a new patient. We calculate a vector of offsets from each voxel within a signal void to each of the landmarks. We then use kNN to classify each voxel as belonging to an artifact or an actual signal void using this offset vector, and fill the artifact voxels with a value representing soft tissue. We tested the method using fourteen patients without artifacts, and eighteen patients with dental artifacts of varying sizes within the anatomical surface of the head/neck region. Though the method wrongly filled a small volume in the bottom part of a maxillary sinus in two patients without any artifacts, due to their abnormal location, it succeeded in filling all dental artifact regions in all patients. In conclusion, we propose a method, which combines ASM and kNN into a simple approach which, as the results show, succeeds to find and correct the dental artifacts within the anatomical surface.

  17. The generic MESSy submodel TENDENCY (v1.0) for process-based analyses in Earth system models

    Science.gov (United States)

    Eichinger, R.; Jöckel, P.

    2014-07-01

    The tendencies of prognostic variables in Earth system models are usually only accessible, e.g. for output, as a sum over all physical, dynamical and chemical processes at the end of one time integration step. Information about the contribution of individual processes to the total tendency is lost, if no special precautions are implemented. The knowledge on individual contributions, however, can be of importance to track down specific mechanisms in the model system. We present the new MESSy (Modular Earth Submodel System) infrastructure submodel TENDENCY and use it exemplarily within the EMAC (ECHAM/MESSy Atmospheric Chemistry) model to trace process-based tendencies of prognostic variables. The main idea is the outsourcing of the tendency accounting for the state variables from the process operators (submodels) to the TENDENCY submodel itself. In this way, a record of the tendencies of all process-prognostic variable pairs can be stored. The selection of these pairs can be specified by the user, tailor-made for the desired application, in order to minimise memory requirements. Moreover, a standard interface allows the access to the individual process tendencies by other submodels, e.g. for on-line diagnostics or for additional parameterisations, which depend on individual process tendencies. An optional closure test assures the correct treatment of tendency accounting in all submodels and thus serves to reduce the model's susceptibility. TENDENCY is independent of the time integration scheme and therefore the concept is applicable to other model systems as well. Test simulations with TENDENCY show an increase of computing time for the EMAC model (in a setup without atmospheric chemistry) of 1.8 ± 1% due to the additional subroutine calls when using TENDENCY. Exemplary results reveal the dissolving mechanisms of the stratospheric tape recorder signal in height over time. The separation of the tendency of the specific humidity into the respective processes (large

  18. The generic MESSy submodel TENDENCY (v1.0 for process-based analyses in Earth system models

    Directory of Open Access Journals (Sweden)

    R. Eichinger

    2014-07-01

    Full Text Available The tendencies of prognostic variables in Earth system models are usually only accessible, e.g. for output, as a sum over all physical, dynamical and chemical processes at the end of one time integration step. Information about the contribution of individual processes to the total tendency is lost, if no special precautions are implemented. The knowledge on individual contributions, however, can be of importance to track down specific mechanisms in the model system. We present the new MESSy (Modular Earth Submodel System infrastructure submodel TENDENCY and use it exemplarily within the EMAC (ECHAM/MESSy Atmospheric Chemistry model to trace process-based tendencies of prognostic variables. The main idea is the outsourcing of the tendency accounting for the state variables from the process operators (submodels to the TENDENCY submodel itself. In this way, a record of the tendencies of all process–prognostic variable pairs can be stored. The selection of these pairs can be specified by the user, tailor-made for the desired application, in order to minimise memory requirements. Moreover, a standard interface allows the access to the individual process tendencies by other submodels, e.g. for on-line diagnostics or for additional parameterisations, which depend on individual process tendencies. An optional closure test assures the correct treatment of tendency accounting in all submodels and thus serves to reduce the model's susceptibility. TENDENCY is independent of the time integration scheme and therefore the concept is applicable to other model systems as well. Test simulations with TENDENCY show an increase of computing time for the EMAC model (in a setup without atmospheric chemistry of 1.8 ± 1% due to the additional subroutine calls when using TENDENCY. Exemplary results reveal the dissolving mechanisms of the stratospheric tape recorder signal in height over time. The separation of the tendency of the specific humidity into the respective

  19. Smart grid initialization reduces the computational complexity of multi-objective image registration based on a dual-dynamic transformation model to account for large anatomical differences

    Science.gov (United States)

    Bosman, Peter A. N.; Alderliesten, Tanja

    2016-03-01

    We recently demonstrated the strong potential of using dual-dynamic transformation models when tackling deformable image registration problems involving large anatomical differences. Dual-dynamic transformation models employ two moving grids instead of the common single moving grid for the target image (and single fixed grid for the source image). We previously employed powerful optimization algorithms to make use of the additional flexibility offered by a dual-dynamic transformation model with good results, directly obtaining insight into the trade-off between important registration objectives as a result of taking a multi-objective approach to optimization. However, optimization has so far been initialized using two regular grids, which still leaves a great potential of dual-dynamic transformation models untapped: a-priori grid alignment with image structures/areas that are expected to deform more. This allows (far) less grid points to be used, compared to using a sufficiently refined regular grid, leading to (far) more efficient optimization, or, equivalently, more accurate results using the same number of grid points. We study the implications of exploiting this potential by experimenting with two new smart grid initialization procedures: one manual expert-based and one automated image-feature-based. We consider a CT test case with large differences in bladder volume with and without a multi-resolution scheme and find a substantial benefit of using smart grid initialization.

  20. The optimal performance estimation for an unknown PEMFC based on the Taguchi method and a generic numerical PEMFC model

    Energy Technology Data Exchange (ETDEWEB)

    Chang, Koan-Yuh [Department of Electronic Engineering, Chienkuo Technology University, No. 1, Chiehshou N. Rd., Changhua City 500 (China); Lin, Huan-Jung [Department of Aeronautical Engineering, National Formosa University, No. 64, Wen-Hwa Rd., Huwei Jen, Yunlin 632 (China); Chen, Pang-Chia [Department of Electrical Engineering, Kao Yuan University, No. 1821, Jhong-Shan Rd., Lu-Jhu Township, Kaohsiung 821 (China)

    2009-02-15

    In this paper, a new approach to estimate the optimal performance of an unknown proton exchange membrane fuel cell (PEMFC) has been proposed. This proposed approach combines the Taguchi method and the numerical PEMFC model. Simulation results obtained using the Taguchi method help to determine the value of control factors that represent the tested unknown PEMFC. The objective of reducing both fuel consumption and operation cost can be achieved by determining the parameters for the unknown PEMFC. In addition, the optimal operation power for the tested unknown PEMFC can also be predicted. Experimental results on the test equipment show that the proposed approach is effective in optimal performance estimation for the tested unknown PEMFC, thus demonstrating the success achieved by combining the Taguchi method and the numerical PEMFC model. (author)

  1. In-Phase Resonances with Generic Transmission Zeros and Eigenvectors of Hamiltonian in Models of Single Channel Transport

    Institute of Scientific and Technical Information of China (English)

    CHEN -Tao; LIU Wen-Sheng; XIONG Shi-Jie

    2001-01-01

    We investigate the phase coherent transport in a single channel system. The theory that the transmission zeros lead to abrupt phase change and in-phase resonances is confirmed numerically in two tight-binding models. After calculating the eigenvalues and eigenvectors of the Harniltonians we also confirmed that the same symmetry of the eigenvectors also leads to the abrupt phase change and in-phase resonances that equal the transmission zero.``

  2. CFD RANS Simulations on a Generic Conventional Scale Model Submarine: Comparison between Fluent and OpenFOAM

    Science.gov (United States)

    2015-09-01

    functions have such a small effect on the simulated value for the drag coefficient as the switch to the laminar behaviour at y+ ~ 11 would be...to explain the source of these differences. The modification to the wall functions in OpenFOAM described in Section 6 partially explains the...model currently implemented in Fluent incorporates modifications for low Reynolds number effects, compressibility and shear flow spreading [11]. The

  3. On the flow of groundwater in closed tunnels. Generic hydrogeological modelling of nuclear waste repository, SFL 3-5

    Energy Technology Data Exchange (ETDEWEB)

    Holmen, J.G. [Uppsala Univ. (Sweden). Inst. of Earth Sciences]|[Golder Associates AB (Sweden)

    1997-06-01

    The purpose is to study the flow of groundwater in closed tunnels by use of mathematical models. The calculations were based on three dimensional models, presuming steady state conditions. The stochastic continuum approach was used for representation of a heterogeneous rock mass. The size of the calculated flow is given as a multiple of an unknown regional groundwater flow. The size of the flow in a tunnel has been studied, as regards: Direction of the regional groundwater flow, Tunnel length, width and conductivity; Heterogeneity of the surrounding rock mass; Flow barriers and encapsulation inside a tunnel. The study includes a model of the planned repository for nuclear waste (SFL 3-5). The flow through the tunnels is estimated for different scenarios. The stochastic continuum approach has been investigated, as regards the representation of a scale dependent heterogeneous conductivity. An analytical method is proposed for the scaling of measured conductivity values, the method is consistent with the stochastic continuum approach. Some general conclusions from the work are: The larger the amount of heterogeneity, the larger the expected flow; The effects of the heterogeneity will decrease with increased tunnel length; If the conductivity of the tunnel is smaller than a threshold value, the tunnel conductivity is the most important parameter; If the tunnel conductivity is large and the tunnel is long, the most important parameter is the direction of the regional flow; Given a heterogeneous rock mass, if the tunnel length is shorter than about 500 m, the heterogeneity will be an important parameter, for lengths shorter than about 250 m, probably the most important; The flow through an encapsulation surrounded by a flow barrier is mainly dependent on the conductivity of the barrier. 70 refs, 110 figs, 10 tabs.

  4. Toward a Computer-Aided Synthesis and Design of Biorefinery Networks: Data Collection and Management Using a Generic Modeling Approach

    DEFF Research Database (Denmark)

    Cheali, Peam; Gernaey, Krist; Sin, Gürkan

    2014-01-01

    Recent research into biorefineries resulted in many competing concepts and technologies for conversion of renewable biobased feedstock into an array of promising products including fuels, chemicals, materials, etc. The topic of this study is collection and management of the complex biorefinery data...... parameters includes reaction yield, utility consumption, and separation efficiency among others, which are identified on the basis of input−output data (generated from rigorous models) collected from detailed biorefinery case studies reported in the open literature. The outcome is a verified database...

  5. Generic medications in ophthalmology.

    Science.gov (United States)

    Zore, Matt; Harris, Alon; Tobe, Leslie Abrams; Siesky, Brent; Januleviciene, Ingrida; Behzadi, Jennifer; Amireskandari, Annahita; Egan, Patrick; Garff, Kevin; Wirostko, Barbara

    2013-03-01

    The purpose of this review is to discuss the process of genericisation of medications in the US and Europe with a focus on ophthalmic drugs. Regulatory guidelines of the US Food and Drug Administration and the European Medicines Agency will be discussed, and the advantages and concerns of genericisation will be explored. We will look at various studies concerning the safety and efficacy of generic drugs compared to their branded counterparts. In particular, the challenges of assuring bioequivalence and therapeutic equivalence in topical ophthalmic drugs will be examined.

  6. Generic patch inference

    DEFF Research Database (Denmark)

    Andersen, Jesper; Lawall, Julia

    2010-01-01

    A key issue in maintaining Linux device drivers is the need to keep them up to date with respect to evolutions in Linux internal libraries. Currently, there is little tool support for performing and documenting such changes. In this paper we present a tool, spdiff, that identifies common changes...... developers can use it to extract an abstract representation of the set of changes that others have made. Our experiments on recent changes in Linux show that the inferred generic patches are more concise than the corresponding patches found in commits to the Linux source tree while being safe with respect...

  7. Development of a Rat Model to Investigate Contributions of Anatomic and Physiologic Determinants of in Vivo Skin Permeation

    Science.gov (United States)

    1991-08-30

    vapor pressure of water (17.5 mm Hg) at room temperature. 54 A. Procedure for assaying Isoflurane in blood Blood samples were analyzed by a...the outward flux of isoflurane through the skin. Isoflurane flux measurements, coupled with blood isoflurane concentrations, were used to calculate...model 34 D. Skin blood flow 35 5. Isoflurane as a model compound for studying skin permeation 39 A. Physicochemical features of isoflurane ... 39 B

  8. Green's Conjecture for the generic canonical curve

    OpenAIRE

    Teixidor-I-Bigas, Montserrat

    1998-01-01

    Green's Conjecture states the following : syzygies of the canonical model of a curve are simple up to the p^th stage if and only if the Clifford index of C is greater than p. We prove that the generic curve of genus g satisfies Green's conjecture.

  9. The AquaDEB project: Physiological flexibility of aquatic animals analysed with a generic dynamic energy budget model (phase II)

    Science.gov (United States)

    Alunno-Bruscia, Marianne; van der Veer, Henk W.; Kooijman, Sebastiaan A. L. M.

    2011-11-01

    This second special issue of the Journal of Sea Research on development and applications of Dynamic Energy Budget (DEB) theory concludes the European Research Project AquaDEB (2007-2011). In this introductory paper we summarise the progress made during the running time of this 5 years' project, present context for the papers in this volume and discuss future directions. The main scientific objectives in AquaDEB were (i) to study and compare the sensitivity of aquatic species (mainly molluscs and fish) to environmental variability within the context of DEB theory for metabolic organisation, and (ii) to evaluate the inter-relationships between different biological levels (individual, population, ecosystem) and temporal scales (life cycle, population dynamics, evolution). AquaDEB phase I focussed on quantifying bio-energetic processes of various aquatic species ( e.g. molluscs, fish, crustaceans, algae) and phase II on: (i) comparing of energetic and physiological strategies among species through the DEB parameter values and identifying the factors responsible for any differences in bioenergetics and physiology; (ii) considering different scenarios of environmental disruption (excess of nutrients, diffuse or massive pollution, exploitation by man, climate change) to forecast effects on growth, reproduction and survival of key species; (iii) scaling up the models for a few species from the individual level up to the level of evolutionary processes. Apart from the three special issues in the Journal of Sea Research — including the DEBIB collaboration (see vol. 65 issue 2), a theme issue on DEB theory appeared in the Philosophical Transactions of the Royal Society B (vol 365, 2010); a large number of publications were produced; the third edition of the DEB book appeared (2010); open-source software was substantially expanded (over 1000 functions); a large open-source systematic collection of ecophysiological data and DEB parameters has been set up; and a series of DEB

  10. Early fetal anatomical sonography.

    LENUS (Irish Health Repository)

    Donnelly, Jennifer C

    2012-10-01

    Over the past decade, prenatal screening and diagnosis has moved from the second into the first trimester, with aneuploidy screening becoming both feasible and effective. With vast improvements in ultrasound technology, sonologists can now image the fetus in greater detail at all gestational ages. In the hands of experienced sonographers, anatomic surveys between 11 and 14 weeks can be carried out with good visualisation rates of many structures. It is important to be familiar with the normal development of the embryo and fetus, and to be aware of the major anatomical landmarks whose absence or presence may be deemed normal or abnormal depending on the gestational age. Some structural abnormalities will nearly always be detected, some will never be and some are potentially detectable depending on a number of factors.

  11. Internal rib structure can be predicted using mathematical models: An anatomic study comparing the chest to a shell dome with application to understanding fractures.

    Science.gov (United States)

    Casha, Aaron R; Camilleri, Liberato; Manché, Alexander; Gatt, Ruben; Attard, Daphne; Gauci, Marilyn; Camilleri-Podesta, Marie-Therese; Mcdonald, Stuart; Grima, Joseph N

    2015-11-01

    The human rib cage resembles a masonry dome in shape. Masonry domes have a particular construction that mimics stress distribution. Rib cortical thickness and bone density were analyzed to determine whether the morphology of the rib cage is sufficiently similar to a shell dome for internal rib structure to be predicted mathematically. A finite element analysis (FEA) simulation was used to measure stresses on the internal and external surfaces of a chest-shaped dome. Inner and outer rib cortical thickness and bone density were measured in the mid-axillary lines of seven cadaveric rib cages using computerized tomography scanning. Paired t tests and Pearson correlation were used to relate cortical thickness and bone density to stress. FEA modeling showed that the stress was 82% higher on the internal than the external surface, with a gradual decrease in internal and external wall stresses from the base to the apex. The inner cortex was more radio-dense, P rib level. The internal anatomical features of ribs, including the inner and outer cortical thicknesses and bone densities, are similar to the stress distribution in dome-shaped structures modeled using FEA computer simulations of a thick-walled dome pressure vessel. Fixation of rib fractures should include the stronger internal cortex. © 2015 Wiley Periodicals, Inc.

  12. NET 40 Generics Beginner's Guide

    CERN Document Server

    Mukherjee, Sudipta

    2012-01-01

    This is a concise, practical guide that will help you learn Generics in .NET, with lots of real world and fun-to-build examples and clear explanations. It is packed with screenshots to aid your understanding of the process. This book is aimed at beginners in Generics. It assumes some working knowledge of C# , but it isn't mandatory. The following would get the most use out of the book: Newbie C# developers struggling with Generics. Experienced C++ and Java Programmers who are migrating to C# and looking for an alternative to other generic frameworks like STL and JCF would find this book handy.

  13. Numerical simulation of pharyngeal airflow applied to obstructive sleep apnea: effect of the nasal cavity in anatomically accurate airway models.

    Science.gov (United States)

    Cisonni, Julien; Lucey, Anthony D; King, Andrew J C; Islam, Syed Mohammed Shamsul; Lewis, Richard; Goonewardene, Mithran S

    2015-11-01

    Repetitive brief episodes of soft-tissue collapse within the upper airway during sleep characterize obstructive sleep apnea (OSA), an extremely common and disabling disorder. Failure to maintain the patency of the upper airway is caused by the combination of sleep-related loss of compensatory dilator muscle activity and aerodynamic forces promoting closure. The prediction of soft-tissue movement in patient-specific airway 3D mechanical models is emerging as a useful contribution to clinical understanding and decision making. Such modeling requires reliable estimations of the pharyngeal wall pressure forces. While nasal obstruction has been recognized as a risk factor for OSA, the need to include the nasal cavity in upper-airway models for OSA studies requires consideration, as it is most often omitted because of its complex shape. A quantitative analysis of the flow conditions generated by the nasal cavity and the sinuses during inspiration upstream of the pharynx is presented. Results show that adequate velocity boundary conditions and simple artificial extensions of the flow domain can reproduce the essential effects of the nasal cavity on the pharyngeal flow field. Therefore, the overall complexity and computational cost of accurate flow predictions can be reduced.

  14. The Impact of Information on Doctors’ Attitudes Toward Generic Drugs

    Directory of Open Access Journals (Sweden)

    Aggeliki V. Tsaprantzi MD

    2016-03-01

    Full Text Available The objective of this study is to assess the impact of information on doctors’ attitudes and perceptions toward generics. A cross-sectional survey based on a specially designed 21-item questionnaire was conducted. The survey involved doctors of different specialties working in a public hospital in Greece. The analysis includes descriptive and inferential statistics, reliability and validity tests, as well as structural equation modeling to evaluate the causal model. Statistical analysis was accomplished by using SPSS 20 and Amos 20. A total of 134 questionnaires out of 162 were received, providing a response rate of 82.71%. A number of significant associations were found between information and perceptions about generic medicines with demographic characteristics. It seems that the provision of quality information on generic drugs influences doctors’ attitudes and prescription practices toward generic drugs. This is not a static process but a rather dynamic issue involving information provision policies for strengthening the proper doctors’ attitudes toward generic drugs.

  15. The Impact of Information on Doctors' Attitudes Toward Generic Drugs.

    Science.gov (United States)

    Tsaprantzi, Aggeliki V; Kostagiolas, Petros; Platis, Charalampos; Aggelidis, Vassilios P; Niakas, Dimitris

    2016-01-01

    The objective of this study is to assess the impact of information on doctors' attitudes and perceptions toward generics. A cross-sectional survey based on a specially designed 21-item questionnaire was conducted. The survey involved doctors of different specialties working in a public hospital in Greece. The analysis includes descriptive and inferential statistics, reliability and validity tests, as well as structural equation modeling to evaluate the causal model. Statistical analysis was accomplished by using SPSS 20 and Amos 20. A total of 134 questionnaires out of 162 were received, providing a response rate of 82.71%. A number of significant associations were found between information and perceptions about generic medicines with demographic characteristics. It seems that the provision of quality information on generic drugs influences doctors' attitudes and prescription practices toward generic drugs. This is not a static process but a rather dynamic issue involving information provision policies for strengthening the proper doctors' attitudes toward generic drugs.

  16. Development of a rate model to investigate contributions of anatomic and physiologic determinants of in vivo skin permeation

    Energy Technology Data Exchange (ETDEWEB)

    Fleischer, N.M.

    1991-01-01

    The skin is a heterogeneous, bi-directional impediment to chemical flux, in which the stratum corneum is a major, though not the sole, rate-limiting barrier layer to permeation. Systemic toxicity following dermal exposure to environmental chemicals and use of skin as a portal for systemic administration of drugs have led to extensive investigations of the inward flux of xenobiotics applied to the outer surface of skin. Those investigations mainly utilized in vitro experimental systems that were limited by the absence of normal physiologic functions. The objective of the present research was to investigate an in vivo skin permeation model system that was sensitive to perturbations of skin capillary physiology and stratum corneum. A [open quotes]fuzzy[close quotes] rat model system was devised that employed outward cutaneous migration of a systemically administered permeation probe, isoflurane. Specially devised, transdermal vapor collection devices were used to capture the outward flux of isoflurane through the skin. Isoflurane flux measurements, coupled with blood isoflurane concentrations, were used to calculate cutaneous permeability coefficients (K[sub p]) of isolflurane, as an index of permeation, under various conditions of normal or perturbed cutaneous physiologic states. Physiologic perturbations were performed to test the sensitivity of the model system to detect effects of minoxidil-mediated vasodilation, phenylephrine-mediated vasoconstriction, and leukotriene D[sub 4]-mediated increased capillary permeability on the outward flux of isoflurane. Tape stripping and topical ether-ethanol application produced either physical removal or chemical disruption of the stratum corneum, respectively. Minoxidil, leukotriene D[sub 4], tape stripping of stratum corneum, and topical ether-ethanol experiments produced statistically significant increases (52 to 193%) in the K[sub p's], while phenylephrine had no significant effect on isoflurane permeation.

  17. Generic Quantum Fourier Transforms

    CERN Document Server

    Moore, Cristopher; Russell, A; Moore, Cristopher; Rockmore, Daniel; Russell, Alexander

    2003-01-01

    The quantum Fourier transform (QFT) is the principal algorithmic tool underlying most efficient quantum algorithms. We present a generic framework for the construction of efficient quantum circuits for the QFT by ``quantizing'' the separation of variables technique that has been so successful in the study of classical Fourier transform computations. Specifically, this framework applies the existence of computable Bratteli diagrams, adapted factorizations, and Gel'fand-Tsetlin bases to offer efficient quantum circuits for the QFT over a wide variety a finite Abelian and non-Abelian groups, including all group families for which efficient QFTs are currently known and many new group families. Moreover, the method gives rise to the first subexponential-size quantum circuits for the QFT over the linear groups GL_k(q), SL_k(q), and the finite groups of Lie type, for any fixed prime power q.

  18. Scroll-wave dynamics in the presence of ionic and conduction inhomogeneities in an anatomically realistic mathematical model for the pig heart

    Science.gov (United States)

    Majumder, R.; Pandit, R.; Panfilov, A. V.

    2016-12-01

    Nonlinear waves of the reaction-diffusion (RD) type occur in many biophysical systems, including the heart, where they initiate cardiac contraction. Such waves can form vortices called scroll waves, which result in the onset of life-threatening cardiac arrhythmias. The dynamics of scroll waves is affected by the presence of inhomogeneities, which, in a very general way, can be of ionic type, i.e., they affect the reaction part, or conduction type, i.e., they affect the diffusion part of an RD-equation. We demostrate, for the first time, by using a state-of-the-art, anatomically realistic model of the pig heart, how differences in the geometrical and biophysical nature of such inhomogeneities can influence scroll-wave dynamics in different ways. Our study reveals that conduction-type inhomogeneities become increasingly important at small length scales, i.e., in the case of multiple, randomly distributed, obstacles in space at the cellular scale (0.2-0.4mm). Such configurations can lead to scroll-wave break up. In contrast, ionic inhomogeneities, affect scroll-wave dynamics significantly at large length scales, when these inhomogeneities are localized in space at the tissue level (5-10mm). In such configurations, these inhomogeneities can attract scroll waves, by pinning them to the heterogeneity, or lead to scroll-wave breakup.

  19. Scroll-wave dynamics in the presence of ionic and conduction inhomogeneities in an anatomically realistic mathematical model for the pig heart

    CERN Document Server

    Majumder, R; Panfilov, A V

    2016-01-01

    Nonlinear waves of the reaction-diffusion (RD) type occur in many biophysical systems, including the heart, where they initiate cardiac contraction. Such waves can form vortices called scroll waves, which result in the onset of life-threatening cardiac arrhythmias. The dynamics of scroll waves is affected by the presence of inhomogeneities, which, in a very general way, can be of \\textit{(i)} ionic type, i.e., they affect the reaction part, or \\textit{(ii)} conduction type, i.e., they affect the diffusion part of an RD equation. We demostrate, for the first time, by using a state-of-the-art, anatomically realistic model of the pig heart, how differences in the geometrical and biophysical nature of such inhomogeneities can influence scroll-wave dynamics in different ways. Our study reveals that conduction-type inhomogeneities become increasingly important at small length scales, i.e., in the case of multiple, randomly distributed, obstacles in space at the cellular scale ($0.2-0.4{\\rm mm}$). Such configuration...

  20. Typed combinators for generic traversal

    NARCIS (Netherlands)

    Lämmel, R.; Vonk, J.

    2001-01-01

    Lacking support for generic traversal, functional programming languages suffer from a scalability problem when applied to large-scale program transformation problems. As a solution, we introduce emph{functional strategies: typeful generic functions that not only can be applied to terms of any type,