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Sample records for generates greatly improved

  1. Affinity maturation generates greatly improved xyloglucan-specific carbohydrate binding modules

    Directory of Open Access Journals (Sweden)

    Cicortas Gunnarsson Lavinia

    2009-10-01

    Full Text Available Abstract Background Molecular evolution of carbohydrate binding modules (CBM is a new approach for the generation of glycan-specific molecular probes. To date, the possibility of performing affinity maturation on CBM has not been investigated. In this study we show that binding characteristics such as affinity can be improved for CBM generated from the CBM4-2 scaffold by using random mutagenesis in combination with phage display technology. Results Two modified proteins with greatly improved affinity for xyloglucan, a key polysaccharide abundant in the plant kingdom crucial for providing plant support, were generated. Both improved modules differ from other existing xyloglucan probes by binding to galactose-decorated subunits of xyloglucan. The usefulness of the evolved binders was verified by staining of plant sections, where they performed better than the xyloglucan-binding module from which they had been derived. They discriminated non-fucosylated from fucosylated xyloglucan as shown by their ability to stain only the endosperm, rich in non-fucosylated xyloglucan, but not the integument rich in fucosylated xyloglucan, on tamarind seed sections. Conclusion We conclude that affinity maturation of CBM selected from molecular libraries based on the CBM4-2 scaffold is possible and has the potential to generate new analytical tools for detection of plant carbohydrates.

  2. Improving Precision of Generated ASTs

    DEFF Research Database (Denmark)

    Winther, Johnni

    The parser-generator is an essential tool in grammarware and its output, the parse tree in form of the concrete or abstract syntax tree, often forms the basis for the whole structure of the grammarware application. Several tools for Java encode the parse tree in a class hierarchy generated to mod...... the parsed documents closely within the Java type system. We present two algorithms used in the generation of such classes which improve the precision with which the parsed input is modeled and show that these improvements greatly ease the use of the generated classes....

  3. Towards Improved Thermoelectric Generator Materials

    Science.gov (United States)

    Julian Goldsmid, H.

    2017-05-01

    Over recent years, new thermoelectric materials have been developed with values for the dimensionless figure of merit, zT, substantially greater than unity. This has opened up the possibility of many new applications, particularly those involving the utilisation of waste heat. However, further improvements are necessary if thermoelectric generation is to have a significant impact on the world's energy problems. It is well known that zT for a single energy band can be related to the Fermi energy and a parameter ( μ/λ L) ( m*/m)3/2, where μ is the carrier mobility, m*/m is the ratio of the carrier effective mass to the mass of a free electron and λ L is the lattice thermal conductivity. However, even when this parameter tends towards infinity, zT does not become much greater than 1 unless the Fermi level lies within the energy gap, far from the appropriate band edge. Thus, the magnitude of the energy gap is becoming of increasing importance. The two-fold requirements of a high value of ( μ/λ L) ( m*/m)3/2 and a sufficiently large energy gap are discussed. It is also shown that the likelihood of the required conditions being met at elevated temperatures can be predicted from low-temperature observations. It is, of course, much more difficult to make accurate determinations of the thermoelectric properties at higher temperatures.

  4. Improving germination and establishment of Great Basin legumes

    Science.gov (United States)

    As part of the Great Basin Native Plant Selection and Increase Project, we have collected and evaluated several native western legumes. Germplasm releases were made, but much work remains to be done concerning how to establish these legumes for seed production and on rangelands. We report herein h...

  5. High Bonding Temperatures Greatly Improve Soy Adhesive Wet Strength

    Directory of Open Access Journals (Sweden)

    Charles R. Frihart

    2016-11-01

    Full Text Available Soy wood adhesive bond strengths reported in different literature studies are difficult to compare because a variety of temperatures and other conditions have been used for the bonding and testing step. Some reports have indicated bond strengths are sensitive to bonding temperature, but the reason(s for this has not been intensively investigated. Although these prior studies differ in other ways (such as type of soy, wood species, and test method, the effect of bonding temperature has not been clearly examined, which is important for focusing commercial applications. A tensile shear test using two-parallel-ply veneer specimens with smooth maple was used to measure both the dry and wet cohesive strength of soy adhesives. Although the soy adhesives gave very good strengths and dry wood failure, they often have low wood failure and shear strengths under wet conditions when bonded at 120 °C. However, wet strength greatly increased as the bonding temperature increased (120, 150 and 180 °C for these two-ply tests with. This study examined the use of different types of soys (flours, concentrates and isolates and different bonding temperatures and bonding conditions to evacuate several possible mechanisms for this temperature sensitivity, with coalescence being the most likely.

  6. Mandated data archiving greatly improves access to research data

    CERN Document Server

    Vines, Timothy H; Bock, Dan G; Franklin, Michelle T; Gilbert, Kimberly J; Kane, Nolan C; Moore, Jean-Sébastien; Moyers, Brook T; Renaut, Sébastien; Rennison, Diana J; Veen, Thor; Yeaman, Sam

    2013-01-01

    The data underlying scientific papers should be accessible to researchers both now and in the future, but how best can we ensure that these data are available? Here we examine the effectiveness of four approaches to data archiving: no stated archiving policy, recommending (but not requiring) archiving, and two versions of mandating data deposition at acceptance. We control for differences between data types by trying to obtain data from papers that use a single, widespread population genetic analysis, STRUCTURE. At one extreme, we found that mandated data archiving policies that require the inclusion of a data availability statement in the manuscript improve the odds of finding the data online almost a thousand-fold compared to having no policy. However, archiving rates at journals with less stringent policies were only very slightly higher than those with no policy at all. At one extreme, we found that mandated data archiving policies that require the inclusion of a data availability statement in the manuscr...

  7. Mandated data archiving greatly improves access to research data.

    Science.gov (United States)

    Vines, Timothy H; Andrew, Rose L; Bock, Dan G; Franklin, Michelle T; Gilbert, Kimberly J; Kane, Nolan C; Moore, Jean-Sébastien; Moyers, Brook T; Renaut, Sébastien; Rennison, Diana J; Veen, Thor; Yeaman, Sam

    2013-04-01

    The data underlying scientific papers should be accessible to researchers both now and in the future, but how best can we ensure that these data are available? Here we examine the effectiveness of four approaches to data archiving: no stated archiving policy, recommending (but not requiring) archiving, and two versions of mandating data deposition at acceptance. We control for differences between data types by trying to obtain data from papers that use a single, widespread population genetic analysis, structure. At one extreme, we found that mandated data archiving policies that require the inclusion of a data availability statement in the manuscript improve the odds of finding the data online almost 1000-fold compared to having no policy. However, archiving rates at journals with less stringent policies were only very slightly higher than those with no policy at all. We also assessed the effectiveness of asking for data directly from authors and obtained over half of the requested datasets, albeit with ∼8 d delay and some disagreement with authors. Given the long-term benefits of data accessibility to the academic community, we believe that journal-based mandatory data archiving policies and mandatory data availability statements should be more widely adopted.

  8. Improved method generates more chlorine dioxide

    Energy Technology Data Exchange (ETDEWEB)

    Jordan, R.W.; Kosinski, A.J.; Baker, R.J.

    1980-10-01

    The addition of acid can greatly improve the chlorine-chlorite process and enhance the use of chlorine dioxide as an alternative to chlorine for disinfection. The process is economical for use in taste and odor control, and for manganese, oxidation. The maximum yield is obtained using no excess chlorine, and the amount of unreacted sodium chlorite and chlorine in the product stream is reduced. (1 diagram, 4 graphs, 9 references)

  9. Beyond the Parental Generation: The Influence of Grandfathers and Great-grandfathers on Status Attainment.

    Science.gov (United States)

    Knigge, Antonie

    2016-08-01

    Studies on intergenerational social mobility usually examine the extent to which social positions of one generation determine the social positions of the next. This study investigates whether the persistence of inequality can be expected to stretch over more than two generations. Using a multigenerational version of GENLIAS, a large-scale database containing information from digitized Dutch marriage certificates during 1812-1922, this study describes and explains the influence of grandfathers and great-grandfathers on the occupational status attainment of 119,662 men in the Netherlands during industrialization. Multilevel regression models show that both grandfather's and great-grandfather's status influence the status attainment of men, after fathers and uncles are taken into account. Whereas the influence of the father and uncles decreases over time, that of the grandfather and great-grandfather remains stable. The results further suggest that grandfathers influence their grandsons through contact but also without being in contact with them. Although the gain in terms of explained variance from using a multigenerational model is moderate, leaving out the influence of the extended family considerably misrepresents the influence of the family on status attainment.

  10. Characterisation of the transcriptome of a wild great tit Parus major population by next generation sequencing

    Directory of Open Access Journals (Sweden)

    Sheldon Ben C

    2011-06-01

    Full Text Available Abstract Background The recent development of next generation sequencing technologies has made it possible to generate very large amounts of sequence data in species with little or no genome information. Combined with the large phenotypic databases available for wild and non-model species, these data will provide an unprecedented opportunity to "genomicise" ecological model organisms and establish the genetic basis of quantitative traits in natural populations. Results This paper describes the sequencing, de novo assembly and analysis from the transcriptome of eight tissues of ten wild great tits. Approximately 4.6 million sequences and 1.4 billion bases of DNA were generated and assembled into 95,979 contigs, one third of which aligned with known Taeniopygia guttata (zebra finch and Gallus gallus (chicken transcripts. The majority (78% of the remaining contigs aligned within or very close to regions of the zebra finch genome containing known genes, suggesting that they represented precursor mRNA rather than untranscribed genomic DNA. More than 35,000 single nucleotide polymorphisms and 10,000 microsatellite repeats were identified. Eleven percent of contigs were expressed in every tissue, while twenty one percent of contigs were expressed in only one tissue. The function of those contigs with strong evidence for tissue specific expression and contigs expressed in every tissue was inferred from the gene ontology (GO terms associated with these contigs; heart and pancreas had the highest number of highly tissue specific GO terms (21.4% and 28.5% respectively. Conclusions In summary, the transcriptomic data generated in this study will contribute towards efforts to assemble and annotate the great tit genome, as well as providing the markers required to perform gene mapping studies in wild populations.

  11. Improved methodology for generating controlled test atmospheres.

    Science.gov (United States)

    Miller, R R; Letts, R L; Potts, W J; McKenna, M J

    1980-11-01

    Improved methodology has been developed for generating controlled test atmospheres. Vaporization of volatile liquids is accomplished in a 28 mm (O.D.) glass J-tube in conjunction with a compressed air flameless heat torch, a pressure-sensitive switch, and a positive displacement piston pump. The vaporization system has been very reliable with a variety of test materials in studies ranging from a few days to several months. The J-tube vaporization assembly minimizes the possibility of thermal decomposition of the test material and affords a better margin of safety when vaporizing potentially explosive materials.

  12. 100 ways to make good photos great tips & techniques for improving your digital photography

    CERN Document Server

    Cope, Peter

    2013-01-01

    A practical, accessible guide to turning your good photographs into great ones whether you are shooting on the latest digital SLR or a camera phone! Discover 100 simple and fun ways to improve your photographs both in-camera and through post-processing image manipulation. Every key photographic genre is covered, from perfect portraits and the great outdoors, to travel photos and shooting at night. Filled with inspirational examples of great photographs compared against the more average images, with easy to follow techniques for how you can achieve the same results.

  13. Assessing community values for reducing agricultural emissions to improve water quality and protect coral health in the Great Barrier Reef

    Science.gov (United States)

    Rolfe, John; Windle, Jill

    2011-12-01

    Policymakers wanting to increase protection of the Great Barrier Reef from pollutants generated by agriculture need to identify when measures to improve water quality generate benefits to society that outweigh the costs involved. The research reported in this paper makes a contribution in several ways. First, it uses the improved science understanding about the links between management changes and reef health to bring together the analysis of costs and benefits of marginal changes, helping to demonstrate the appropriate way of addressing policy questions relating to reef protection. Second, it uses the scientific relationships to frame a choice experiment to value the benefits of improved reef health, with the results of mixed logit (random parameter) models linking improvements explicitly to changes in "water quality units." Third, the research demonstrates how protection values are consistent across a broader population, with some limited evidence of distance effects. Fourth, the information on marginal costs and benefits that are reported provide policymakers with information to help improve management decisions. The results indicate that while there is potential for water quality improvements to generate net benefits, high cost water quality improvements are generally uneconomic. A major policy implication is that cost thresholds for key pollutants should be set to avoid more expensive water quality proposals being selected.

  14. Improved LabVIEW Code Generation

    National Research Council Canada - National Science Library

    Evita Vavilina; Gatis Gaigals

    2016-01-01

    .... LabVIEW provides highly convenient environment for simulation development and also tools for generation of simulation environment that can include simulation itself and collection of simulation data...

  15. Improved discriminative training for generative model

    Institute of Scientific and Technical Information of China (English)

    WU Ya-hui; GUO Jun; LIU Gang

    2009-01-01

    This article proposes a model combination method to enhance the discriminability of the generative model. Generative and discriminative models have different optimization objectives and have their own advantages and drawbacks. The method proposed in this article intends to strike a balance between the two models mentioned above. It extracts the discriminative parameter from the generative model and generates a new model based on a multi-model combination. The weight for combining is determined by the ratio of the inter-variance to the intra-variance of the classes. The higher the ratio is, the greater the weight is, and the more discriminative the model will be. Experiments on speech recognition demonstrate that the performance of the new model outperforms the model trained with the traditional generative method.

  16. Improved catalytic activity of laser generated bimetallic and trimetallic nanoparticles.

    Science.gov (United States)

    Singh, Rina; Soni, R K

    2014-09-01

    We report synthesis of silver nanoparticles, bimetallic (Al2O3@Ag) nanoparticles and trimetallic (Al2O3@AgAu) nanoparticles by nanosecond pulse laser ablation (PLA) in deionized water. Two-step laser ablation methodologies were adopted for the synthesis of bi- and tri-metallic nanoparticles. In this method a silver or gold target was ablated in colloidal solution of γ-alumina nanoparticles prepared by PLA. The TEM image analysis of bimetallic and trimetallic particles reveals deposition of fine silver particles and Ag-Au alloy particles, respectively, on large alumina particles. The laser generated nanoparticles were tested for catalytic reduction of 4-nitrophenol to 4-aminophenol and showed excellent catalytic behaviour. The catalytic rate was greatly improved by incorporation of additional metal in silver nanoparticles. The catalytic efficiency of trimetallic Al2O3@AgAu for reduction of 4-nitrophenol to 4-aminophenol was remarkably enhanced and the catalytic reaction was completed in just 5 sec. Even at very low concentration, both Al2O3@Ag nanoparticles and Al2O3@AgAu nanoparticles showed improved rate of catalytic reduction than monometallic silver nanoparticles. Our results demonstrate that alumina particles in the solution not only provide the active sites for particle dispersion but also improve the catalytic activity.

  17. Factors affecting adoption of improved management practices in the pastoral industry in Great Barrier Reef catchments.

    Science.gov (United States)

    Rolfe, John; Gregg, Daniel

    2015-07-01

    Substantial efforts are being made by industry and government in Australia to reduce adverse impacts of pastoral operations on water quality draining to the Great Barrier Reef. A key target is to achieve rapid adoption of better management practices by landholders, but current theoretical frameworks provide limited guidance about priorities for improving adoption. In this study information from direct surveys with landholders in the two largest catchments draining into the Great Barrier Reef has been collected and analysed. Study outcomes have important implications for policy settings, because they confirm that substantial variations in adoption drivers exist across landholders, enterprises and practices. The results confirm that the three broad barriers to adoption of information gaps, financial incentives and risk perceptions are relevant. This implies that different policy mechanisms, including extension and incentive programs, remain important, although financial incentives were only identified as important to meet capital and transformational costs rather than recurrent costs.

  18. What factors were important for dietary improvement in emergency shelters after the Great East Japan Earthquake?

    Science.gov (United States)

    Tsuboyama-Kasaoka, Nobuyo; Hoshi, Yuko; Onodera, Kazue; Mizuno, Shoichi; Sako, Kazuko

    2014-01-01

    The Great East Japan Earthquake of 2011 left many evacuees with insufficient food and emergency shelter. However, there is no evidence concerning the factors affecting dietary circumstances in emergency shelters after disasters. To clarify the factors that influenced the provision of meals, we reanalyzed a data set from a dietary survey conducted in emergency shelters one month after the Great East Japan Earthquake (2011). Among the 69 shelters in "city A," 53 (79.1%) had food shortages. The possibility of cooking in the emergency shelter improved the provision of meals to evacuees. When comparing emergency shelters with and without cooking equipment, the shelters with cooking equipment provided more meals, as well as more dishes containing grains and vegetables. When there was a gas supply, the twice per day provision of "balanced" meals (containing grains, vegetables, and meat/fish) was more frequent than when there was no gas supply. Interestingly, neither the water supply nor the electricity supply affected the provision of balanced meals. Further, emergency shelters with larger numbers of evacuees had a lower possibility of cooking and lower availability of gas supply. Our results demonstrate that early improvements to post-disaster meal provision may maintain the health of evacuees. Such improvements could be achieved by 1) the speedy restoration of the gas supply to enable cooking, and 2) limiting the number of evacuees per emergency shelter.

  19. Colony color assay coupled with 5FOA negative selection greatly improves yeast threehybrid library screening efficiency

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    The recently developed yeast three-hybrid system is a powerful tool for analyzing RNA-protein interactions in vivo. However, large numbers of false positives are frequently met due to bait RNA-independent activation of the reporter gene in the library screening using this system. In this report, we coupled the colony color assay with the 5FOA (5-fluoroorotic acid) negative selection in the library screening, and found that this coupled method effectively eliminated bait RNA-independent false positives and hence greatly improved library screening efficiency. We used this method successfully in isolation of cDNA of an RNA-binding protein that might play important roles in certain cellular process. This improvement will facilitate the use of the yeast three-hybrid system in analyzing RNA-protein interaction.

  20. Optimizing hyaluronidase dose and plasmid DNA delivery greatly improves gene electrotransfer efficiency in rat skeletal muscle

    DEFF Research Database (Denmark)

    Åkerström, Thorbjörn; Vedel, Kenneth; Needham Andersen, Josefine;

    2015-01-01

    delivery across the muscle by increasing the number of plasmid DNA injections further enhanced transfection efficiency whereas increasing plasmid dose from 0.2 to 1.6. μg/g b.w. or vehicle volume had no effect. The optimized protocol resulted in ~80% (CI95%: 79-84%) transfected muscle fibers......Transfection of rat skeletal muscle in vivo is a widely used research model. However, gene electrotransfer protocols have been developed for mice and yield variable results in rats. We investigated whether changes in hyaluronidase pre-treatment and plasmid DNA delivery can improve transfection...... with a homogenous distribution. We also show that transfection was stable over five weeks of regular exercise or inactivity. Our findings show that species-specific plasmid DNA delivery and hyaluronidase pre-treatment greatly improves transfection efficiency in rat skeletal muscle....

  1. KSR-Based Medium Improves the Generation of High-Quality Mouse iPS Cells

    OpenAIRE

    2014-01-01

    Induced pluripotent stem (iPS) cells from somatic cells have great potential for regenerative medicine. The efficiency in generation of iPS cells has been significantly improved in recent years. However, the generation of high-quality iPS cells remains of high interest. Consistently, we demonstrate that knockout serum replacement (KSR)-based medium accelerates iPS cell induction and improves the quality of iPS cells, as confirmed by generation of chimeras and all iPS cell-derived offspring wi...

  2. Improvement of power quality using distributed generation

    Energy Technology Data Exchange (ETDEWEB)

    Moreno-Munoz, A.; Lopez-Rodriguez, M.A.; Flores-Arias, J.M.; Bellido-Outerino, F.J. [Universidad de Cordoba, Departamento A.C., Electronica y T.E., Escuela Politecnica Superior, Campus de Rabanales, E-14071 Cordoba (Spain); de-la-Rosa, J.J.G. [Universidad de Cadiz, Area de Electronica, Dpto. ISA, TE y Electronica, Escuela Politecnica Superior Avda, Ramon Puyol, S/N, E-11202-Algeciras-Cadiz (Spain); Ruiz-de-Adana, M. [Universidad de Cordoba, Departamento de Quimica Fisica y Termodinamica Aplicada, Campus de Rabanales, E-14071 Cordoba (Spain)

    2010-12-15

    This paper addresses how Distributed Generation (DG), particularly when configured in Combined Heat and Power (CHP) mode, can become a powerful reliability solution in highlight automated factories, especially when integrated with complimentary Power Quality (PQ) measures. The paper presents results from the PQ audit conducted at a highly automated plant over last year. It was found that the main problems for the equipment installed were voltage sags. Among all categories of electrical disturbances, the voltage sag (dip) and momentary interruption are the nemeses of the automated industrial process. The paper analyzes the capabilities of modern electronic power supplies and the convenience of embedded solution. Finally it is addressed the role of the DG/CHP on the reliability of digital factories. (author)

  3. The great divide: social media's role in bridging healthcare's generational shift.

    Science.gov (United States)

    Sarringhaus, Meredith M

    2011-01-01

    Social media, a resource largely untapped in the healthcare field, presents opportunities and advantages and, if used properly, can innovate healthcare and create a competitive advantage for adopters. Many organizations have considered social media but dismissed its advantages as fleeting products of the new generation entering the workforce: the millennials. However, the millennial generation has assumed a greater presence in clinical and administrative positions as the baby boomer generation prepares for retirement. This article advocates the adoption of social media in healthcare organizations as a strategic advantage in connecting with their patient population and recruiting and retaining millennial staff amid the generational shift of the healthcare workforce.

  4. Drawing a Crowd: Graphic Novel Events Are Great Ways to Generate Excitement

    Science.gov (United States)

    MacDonald, Heidi

    2004-01-01

    As graphic novels grow in popularity, with teen readers, libraries are finding the world of comics, manga, and anime a fertile field for inspiring events, as well as a great way to promote libraries to teens in general. These events can range from simple--a reading/signing--to elaborate--workshops, or even a mini convention. All provide a unique…

  5. CMB anisotropies generated by cosmic voids and great attractors. [Cosmic microwave background

    Energy Technology Data Exchange (ETDEWEB)

    Martinez-Gonzalez, E.; Sanz, J.L. (Cantabria Univ., Santander (Spain). Dept. Fisica Moderna)

    1990-12-01

    A recent result, based on the potential approximation, concerning the effect of a non-static gravitational potential on the propagation of light, is used to study the influence of compensated and uncompensated non-linear structures on the cosmic microwave background radiation. We obtain the temperature profile as well as the deflection of the microwave photons produced by the cosmic voids and great attractors whose existence has recently been claimed in the literature. (author).

  6. Greatly Suppressed Shuttle Effect for Improved Lithium Sulfur Battery Performance through Short Chain Intermediates.

    Science.gov (United States)

    Xu, Na; Qian, Tao; Liu, Xuejun; Liu, Jie; Chen, Yu; Yan, Chenglin

    2017-01-11

    The high solubility of long-chain lithium polysulfides and their infamous shuttle effect in lithium sulfur battery lead to rapid capacity fading along with low Coulombic efficiency. To address above issues, we propose a new strategy to suppress the shuttle effect for greatly enhanced lithium sulfur battery performance mainly through the formation of short-chain intermediates during discharging, which allows significant improvements including high capacity retention of 1022 mAh/g with 87% retention for 450 cycles. Without LiNO3-containing electrolytes, the excellent Coulombic efficiency of ∼99.5% for more than 500 cycles is obtained, suggesting the greatly suppressed shuttle effect. In situ UV/vis analysis of electrolyte during cycling reveals that the short-chain Li2S2 and Li2S3 polysulfides are detected as main intermediates, which are theoretically verified by density functional theory (DFT) calculations. Our strategy may open up a new avenue for practical application of lithium sulfur battery.

  7. Guiding principles for the improved governance of port and shipping impacts in the Great Barrier Reef.

    Science.gov (United States)

    Grech, A; Bos, M; Brodie, J; Coles, R; Dale, A; Gilbert, R; Hamann, M; Marsh, H; Neil, K; Pressey, R L; Rasheed, M A; Sheaves, M; Smith, A

    2013-10-15

    The Great Barrier Reef (GBR) region of Queensland, Australia, encompasses a complex and diverse array of tropical marine ecosystems of global significance. The region is also a World Heritage Area and largely within one of the world's best managed marine protected areas. However, a recent World Heritage Committee report drew attention to serious governance problems associated with the management of ports and shipping. We review the impacts of ports and shipping on biodiversity in the GBR, and propose a series of guiding principles to improve the current governance arrangements. Implementing these principles will increase the capacity of decision makers to minimize the impacts of ports and shipping on biodiversity, and will provide certainty and clarity to port operators and developers. A 'business as usual' approach could lead to the GBR's inclusion on the List of World Heritage in Danger in 2014.

  8. Requirements and benefits of flow forecasting for improving hydropower generation

    NARCIS (Netherlands)

    Dong, Xiaohua; Vrijling, J.K.; Dohmen-Janssen, Catarine M.; Ruigh, E.; Booij, Martijn J.; Stalenberg, B.; Hulscher, Suzanne J.M.H.; van Gelder, P.H.A.J.M.; Verlaan, M.; Zijderveld, A.; Waarts, P.

    2005-01-01

    This paper presents a methodology to identify the required lead time and accuracy of flow forecasting for improving hydropower generation of a reservoir, by simulating the benefits (in terms of electricity generated) obtained from the forecasting with varying lead times and accuracies. The

  9. Requirements and benefits of flow forecasting for improving hydropower generation

    NARCIS (Netherlands)

    Dong, X.; Dohmen-Janssen, C.M.; Booij, M.J.; Hulscher, S.J.M.H.

    2005-01-01

    This paper presents a methodology to identify the required lead time and accuracy of flow forecasting for improving hydropower generation of a reservoir, by simulating the benefits (in terms of electricity generated) obtained from the forecasting with varying lead times and accuracies. The benefit-l

  10. Carbon supersaturation due to paraequilibrium carburization: Stainless steels with greatly improved mechanical properties

    Energy Technology Data Exchange (ETDEWEB)

    Michal, G.M. [Department of Materials Science and Engineering, Case Western Reserve University, 10900 Euclid Ave., Cleveland, OH 44106 7204 (United States)]. E-mail: gmm3@case.edu; Ernst, F. [Department of Materials Science and Engineering, Case Western Reserve University, 10900 Euclid Ave., Cleveland, OH 44106 7204 (United States)]. E-mail: frank.ernst@case.edu; Kahn, H. [Department of Materials Science and Engineering, Case Western Reserve University, 10900 Euclid Ave., Cleveland, OH 44106 7204 (United States)]. E-mail: harold.kahn@case.edu; Cao, Y. [Department of Materials Science and Engineering, Case Western Reserve University, 10900 Euclid Ave., Cleveland, OH 44106 7204 (United States); Oba, F. [Department of Materials Science and Engineering, Case Western Reserve University, 10900 Euclid Ave., Cleveland, OH 44106 7204 (United States); Agarwal, N. [Department of Materials Science and Engineering, Case Western Reserve University, 10900 Euclid Ave., Cleveland, OH 44106 7204 (United States); Heuer, A.H. [Department of Materials Science and Engineering, Case Western Reserve University, 10900 Euclid Ave., Cleveland, OH 44106 7204 (United States)]. E-mail: heuer@case.edu

    2006-04-15

    Low-temperature gas-phase carburization has been used to generate very high surface interstitial carbon contents, up to {approx}12 at.%, in a 316L austenitic stainless steel. The high interstitial content leads to substantial surface hardening (Vickers hardness of {approx}12 GPa, equivalent to Rockwell C of {approx}71.5) with essentially no loss of ductility and with no carbide formation. Residual compressive stresses accompanying the low-temperature carburization enhance the high-cycle fatigue resistance, while the hardening enhances the wear resistance. These remarkable improvements in mechanical properties arise because the carburization is carried out at temperatures where 'paraequilibrium', rather than conventional thermodynamic equilibrium, determines the phase composition; paraequilibrium can be realized under conditions where substitutional solutes such as Cr and Ni are immobile whereas interstitial solutes such as carbon are not.

  11. Evidence for a tsunami generated by the 1762 Great Arakan earthquake, Southeastern Bangladesh

    Science.gov (United States)

    Gurung, D.; McHugh, C. M.; Mondal, D. R.; Seeber, L.; Steckler, M. S.; Bastas-Hernandez, A.; Akhter, S. H.; Mustaque, S.; Goodbred, S. L., Jr.

    2014-12-01

    The devastating 2004 Sumatra earthquake and tsunami brought to the world's attention the possibility of large megathrust ruptures occurring along the heavily populated coast of Bangladesh. The Sunda-Andaman subduction arc continues into Bangladesh where oblique convergence of the Indian plate with the Burma segment of the arc was measured at GPS rates of 14 mm/yr. A long section of the megathurst ruptured during the 1762 Great Arakan earthquake along the Myanmar coast. A 1762 tsunami was reported from historic accounts and predicted from modelling, but geologic evidence for it was not previously reported. St Martin's Island and the Teknaf peninsula in SE Bangladesh are expressions of anticlines in the outer part of the accretionary prism of the Arakan subduction boundary. Our lithology, biostratigraphy and C-14 ages in this region provide evidence for a possible tsunami associated with the 1762 earthquake and validate the continuity of the rupture zone for as much as 700 km, from the Myanmar coast, Bay of Bengal shelf to the Sitakund anticline inland. In St. Martin's, ≈70 km north of the shelf break, U-Th ages from ~2 m uplifted dead corals provide evidence for the 1762 rupture. The associated tsunami was dated from benthic foraminifers and marine molluscs obtained from a shell bed in a trench, and from the top of marine terraces possibly uplifted during 1762 or prior earthquakes. In Teknaf a chaotic bed containing benthic foraminifers, marine shells and cobble size rocks, extends for 100's of meters on top of the 2 m uplifted terrace. The marine molluscs were dated at 1695-1791 AD. The large ≈2m uplift found in the region is likely to be deformation associated with the 1762 rupture and could also be partly related to anelastic growth of the accretion wedge and anticlines. It is likely now slowly subsiding due to continuing elastic loading of the megathrust. To produce that large coastal, presumably coseismic, uplift, the megathrust rupture must have reached at

  12. Methodologies for Improved Tag Cloud Generation with Clustering

    DEFF Research Database (Denmark)

    Leginus, Martin; Dolog, Peter; Lage, Ricardo Gomes

    2012-01-01

    coverage and overlap. We study several clustering algorithms to generate tag clouds. We show that by extending cloud generation based on tag popularity with clustering we slightly improve coverage. We also show that if the cloud is generated by clustering independently of the tag popularity baseline we......Tag clouds are useful means for navigation in the social web systems. Usually the systems implement the tag cloud generation based on tag popularity which is not always the best method. In this paper we propose methodologies on how to combine clustering into the tag cloud generation to improve...... better on bibsonomy due to its specific focus. The best performing is the hierarchical clustering....

  13. Using SMAP data to improve drought early warning over the US Great Plains

    Science.gov (United States)

    Fu, R.; Fernando, N.; Tang, W.

    2015-12-01

    A drought prone region such as the Great Plains of the United States (US GP) requires credible and actionable drought early warning. Such information cannot simply be extracted from available climate forecasts because of their large uncertainties at regional scales, and unclear connections to the needs of the decision makers. In particular, current dynamic seasonal predictions and climate projections, such as those produced by the NOAA North American Multi-Model Ensemble experiment (NMME) are much more reliable for winter and spring than for the summer season for the US GP. To mitigate the weaknesses of dynamic prediction/projections, we have identified three key processes behind the spring-to-summer dry memory through observational studies, as the scientific basis for a statistical drought early warning system. This system uses percentile soil moisture anomalies in spring as a key input to provide a probabilistic summer drought early warning. The latter outperforms the dynamic prediction over the US Southern Plains and has been used by the Texas state water agency to support state drought preparedness. A main source of uncertainty for this drought early warning system is the soil moisture input obtained from the NOAA Climate Forecasting System (CFS). We are testing use of the beta version of NASA Soil Moisture Active Passive (SMAP) soil moisture data, along with the Soil Moisture and Ocean Salinity (SMOS), and the long-term Essential Climate Variable Soil Moisture (ECV-SM) soil moisture data, to reduce this uncertainty. Preliminary results based on ECV-SM suggests satellite based soil moisture data could improve early warning of rainfall anomalies over the western US GP with less dense vegetation. The skill degrades over the eastern US GP where denser vegetation is found. We evaluate our SMAP-based drought early warning for 2015 summer against observations.

  14. Economic Dispatch Thermal Generator Using Modified Improved Particle Swarm Optimization

    Directory of Open Access Journals (Sweden)

    M. Natsir Rahman

    2012-07-01

    Full Text Available Fuel cost of a thermal generator is its own load functions. In this research, Modified Improved Particle Swarm Optimization (MIPSO is applied to calculate economic dispatch. Constriction Factor Approach (CFA is used to modify IPSO algorithm because of the advantage to improve the ability of global searching and avoid local minimum so that the time needed to converge become faster. Simulation results achieved by using  MIPSO method at the time of peak load of of 9602 MW, obtained generation cost is Rp 7,366,912,798,34 per hour, while generation cost of real system is Rp. 7,724,012,070.30 per hour. From the simulation result can be concluded that MIPSO can reduce the generation cost of  500 kV Jawa Bali transmission system of Rp 357,099,271.96 per hour or equal to 4,64%.

  15. Economic Dispatch Thermal Generator Using Modified Improved Particle Swarm Optimization

    Directory of Open Access Journals (Sweden)

    M. Natsir Rahman

    2012-09-01

    Full Text Available Fuel cost of a thermal generator is its own load functions. In this research, Modified Improved Particle Swarm Optimization (MIPSO is applied to calculate economic dispatch. Constriction Factor Approach (CFA is used to modify IPSO algorithm because of the advantage to improve the ability of global searching and avoid local minimum so that the time needed to converge become faster. Simulation results achieved by using  MIPSO method at the time of peak load of of 9602 MW, obtained generation cost is Rp 7,366,912,798,34 per hour, while generation cost of real system is Rp. 7,724,012,070.30 per hour. From the simulation result can be concluded that MIPSO can reduce the generation cost of  500 kV Jawa Bali transmission system of Rp 357,099,271.96 per hour or equal to 4,64%.

  16. Requirements and benefits of flow forecasting for improving hydropower generation

    OpenAIRE

    Dong, Xiaohua; Vrijling, J. K.; Dohmen-Janssen, Catarine M.; Ruigh, E.; Booij, Martijn J.; Stalenberg, B.; Hulscher, Suzanne J.M.H.; Van Gelder, P.H.A.J.M.; Verlaan, M.; Zijderveld, A; Waarts, P.

    2005-01-01

    This paper presents a methodology to identify the required lead time and accuracy of flow forecasting for improving hydropower generation of a reservoir, by simulating the benefits (in terms of electricity generated) obtained from the forecasting with varying lead times and accuracies. The benefit-lead time relationship was investigated only for perfect inflow forecasts, with a few selected forecasting lead times: 4, 10 days and 1 year. The water level and the release from the reservoir were ...

  17. Work system innovation: Designing improvement methods for generative capability

    DEFF Research Database (Denmark)

    Hansen, David; Møller, Niels

    2013-01-01

    This paper explores how a work system’s capability for improvement is influenced by its improvement methods. Based on explorative case study at a Lean manufacturing facility, the methods problem solving and Appreciative Inquiry were compared through in-depth qualitative studies over a 12-month...... period. The findings show how problem solving leads to solutions inside the existing improvement trajectory, whereas Appreciative Inquiry due to increased generative capability enables solutions outside the existing trajectory. The paper suggests how improvement methods can be designed for appropriate...

  18. Leveraging Big Data to Improve Health Awareness Campaigns: A Novel Evaluation of the Great American Smokeout

    Science.gov (United States)

    Westmaas, J Lee; Leas, Eric C; Benton, Adrian; Chen, Yunqi; Dredze, Mark; Althouse, Benjamin M

    2016-01-01

    Background Awareness campaigns are ubiquitous, but little is known about their potential effectiveness because traditional evaluations are often unfeasible. For 40 years, the “Great American Smokeout” (GASO) has encouraged media coverage and popular engagement with smoking cessation on the third Thursday of November as the nation’s longest running awareness campaign. Objective We proposed a novel evaluation framework for assessing awareness campaigns using the GASO as a case study by observing cessation-related news reports and Twitter postings, and cessation-related help seeking via Google, Wikipedia, and government-sponsored quitlines. Methods Time trends (2009-2014) were analyzed using a quasi-experimental design to isolate spikes during the GASO by comparing observed outcomes on the GASO day with the simulated counterfactual had the GASO not occurred. Results Cessation-related news typically increased by 61% (95% CI 35-87) and tweets by 13% (95% CI −21 to 48) during the GASO compared with what was expected had the GASO not occurred. Cessation-related Google searches increased by 25% (95% CI 10-40), Wikipedia page visits by 22% (95% CI −26 to 67), and quitline calls by 42% (95% CI 19-64). Cessation-related news media positively coincided with cessation tweets, Internet searches, and Wikipedia visits; for example, a 50% increase in news for any year predicted a 28% (95% CI −2 to 59) increase in tweets for the same year. Increases on the day of the GASO rivaled about two-thirds of a typical New Year’s Day—the day that is assumed to see the greatest increases in cessation-related activity. In practical terms, there were about 61,000 more instances of help seeking on Google, Wikipedia, or quitlines on GASO each year than would normally be expected. Conclusions These findings provide actionable intelligence to improve the GASO and model how to rapidly, cost-effectively, and efficiently evaluate hundreds of awareness campaigns, nearly all for the first

  19. Species-Specific Chromosome Engineering Greatly Improves Fully Human Polyclonal Antibody Production Profile in Cattle.

    Directory of Open Access Journals (Sweden)

    Hiroaki Matsushita

    Full Text Available Large-scale production of fully human IgG (hIgG or human polyclonal antibodies (hpAbs by transgenic animals could be useful for human therapy. However, production level of hpAbs in transgenic animals is generally very low, probably due to the fact that evolutionarily unique interspecies-incompatible genomic sequences between human and non-human host species may impede high production of fully hIgG in the non-human environment. To address this issue, we performed species-specific human artificial chromosome (HAC engineering and tested these engineered HAC in cattle. Our previous study has demonstrated that site-specific genomic chimerization of pre-B cell receptor/B cell receptor (pre-BCR/BCR components on HAC vectors significantly improves human IgG expression in cattle where the endogenous bovine immunoglobulin genes were knocked out. In this report, hIgG1 class switch regulatory elements were subjected to site-specific genomic chimerization on HAC vectors to further enhance hIgG expression and improve hIgG subclass distribution in cattle. These species-specific modifications in a chromosome scale resulted in much higher production levels of fully hIgG of up to 15 g/L in sera or plasma, the highest ever reported for a transgenic animal system. Transchromosomic (Tc cattle containing engineered HAC vectors generated hpAbs with high titers against human-origin antigens following immunization. This study clearly demonstrates that species-specific sequence differences in pre-BCR/BCR components and IgG1 class switch regulatory elements between human and bovine are indeed functionally distinct across the two species, and therefore, are responsible for low production of fully hIgG in our early versions of Tc cattle. The high production levels of fully hIgG with hIgG1 subclass dominancy in a large farm animal species achieved here is an important milestone towards broad therapeutic applications of hpAbs.

  20. Molecular Breeding for Improved Second Generation Bioenergy Crops.

    Science.gov (United States)

    Allwright, Mike R; Taylor, Gail

    2016-01-01

    There is increasing urgency to develop and deploy sustainable sources of energy to reduce our global dependency on finite, high-carbon fossil fuels. Lignocellulosic feedstocks, used in power and liquid fuel generation, are valuable sources of non-food plant biomass. They are cultivated with minimal inputs on marginal or degraded lands to prevent competition with arable agriculture and offer significant potential for sustainable intensification (the improvement of yield without the necessity for additional inputs) through advanced molecular breeding. This article explores progress made in next generation sequencing, advanced genotyping, association genetics, and genetic modification in second generation bioenergy production. Using poplar as an exemplar where most progress has been made, a suite of target traits is also identified giving insight into possible routes for crop improvement and deployment in the immediate future.

  1. Power Quality Improvement of a Distributed Generation Power System

    Directory of Open Access Journals (Sweden)

    Panga Harish

    2016-06-01

    Full Text Available The aim of this work is to improve the power quality for Distributed Generation (DG with power storage system. Power quality is the combination of voltage quality and current quality. Power quality is the set of limits of electrical properties that allows electrical systems to function in their intended manner without significant loss of performance or life. The electrical power quality is more concerned issue. The main problems are stationery and transient distortions in the line voltage such as harmonics, flicker, swells, sags and voltage asymmetries. Distributed Generation (DG also called as site generation, dispersed generation, embedded generation, decentralized generation, decentralized energy or distributed energy, generates electricity from the many small energy sources. In recent years, micro electric power systems such as photovoltaic generation systems, wind generators and micro gas turbines, etc., have increased with the deregulation and liberalization of the power market. Under such circumstances the environment surrounding the electric power industry has become ever more complicated and provides high-quality power in a stable manner which becomes an important topic. Here DG is assumed to include Wind power Generation (WG and Fuel Cells (FC, etc. Advantages of this system are constant power supply, constant voltage magnitude, absence of harmonics insupply voltage, un-interrupted power supply. In this project the electric power qualities in two cases will be compared. Case I: With the storage battery when it is introduced. Case II: Without the storage battery. The storage battery executes the control that maintains the voltage in the power system. It will be found that the Electric power quality will be improved, when storage battery is introduced. The model system used in this Project work is composed of a Wind Turbine, an Induction Generator, Fuel Cells, An Inverter and a Storage Battery. A miniature Wind Power Generator is

  2. Self-generated retrievals while multitasking improve memory for names.

    Science.gov (United States)

    Helder, Elizabeth; Shaughnessy, John J

    2011-11-01

    We used a translational research paradigm to investigate whether distributed retrievals could benefit name learning in social situations. Undergraduates (N=64) were trained to generate distributed retrievals while they were multitasking. Students learned to generate distributed retrievals according to either an expanding or a uniform schedule. Their self-generated distributed retrievals while they were multitasking were effective in improving name recall for both retrieval schedules. The increase with self-generated retrievals while multitasking was greater (η² =.76) than the increase that Helder and Shaughnessy ( 2008 ) found with experimenter-controlled retrievals while multitasking (η² =.42). These findings provide evidence that the beneficial effect of distributed retrievals can extend to learning names in a social situation.

  3. Improved Method to Generate Path-Wise Test Data

    Institute of Scientific and Technical Information of China (English)

    SHAN JinHui(单锦辉); WANG Ji(王戟); QI ZhiChng(齐治昌); WU JianPing(吴建平)

    2003-01-01

    Gupta et al., proposed a method, which is referred to as the Iterative RelaxationMethod, to generate test data for a given path in a program by linearizing the predicate functions.In this paper, a model language is presented and the properties of static and dynamic data depen-dencies are investigated. The notions in the Iterative Relaxation Method are defined formally. Thepredicate slice proposed by Gupta et al. is extended to path-wise static slice. The correctness ofthe constructional algorithm is proved afterward. The improvement shows that the constructionsof predicate slice and input dependency set can be omitted. The equivalence of systems of con-straints generated by both methods is proved. The prototype of path-wise test data generator ispresented in this paper. The experiments show that our method is practical, and fits the path-wiseautomatic generation of test data for both white-box testing and black-box testing.

  4. Improved Ant Algorithms for Software Testing Cases Generation

    Directory of Open Access Journals (Sweden)

    Shunkun Yang

    2014-01-01

    Full Text Available Existing ant colony optimization (ACO for software testing cases generation is a very popular domain in software testing engineering. However, the traditional ACO has flaws, as early search pheromone is relatively scarce, search efficiency is low, search model is too simple, positive feedback mechanism is easy to porduce the phenomenon of stagnation and precocity. This paper introduces improved ACO for software testing cases generation: improved local pheromone update strategy for ant colony optimization, improved pheromone volatilization coefficient for ant colony optimization (IPVACO, and improved the global path pheromone update strategy for ant colony optimization (IGPACO. At last, we put forward a comprehensive improved ant colony optimization (ACIACO, which is based on all the above three methods. The proposed technique will be compared with random algorithm (RND and genetic algorithm (GA in terms of both efficiency and coverage. The results indicate that the improved method can effectively improve the search efficiency, restrain precocity, promote case coverage, and reduce the number of iterations.

  5. Improved side information generation for distributed video coding

    DEFF Research Database (Denmark)

    Huang, Xin; Forchhammer, Søren

    2008-01-01

    information generation method, fewer bits will be requested from the encoder and more reliable decoded frames will be obtained. In this paper, a side information generation method is introduced to further improve the rate-distortion (RD) performance of transform domain distributed video coding. This algorithm......As a new coding paradigm, distributed video coding (DVC) deals with lossy source coding using side information to exploit the statistics at the decoder to reduce computational demands at the encoder. The performance of DVC highly depends on the quality of side information. With a better side...

  6. Efficient Generation and Selection of Combined Features for Improved Classification

    KAUST Repository

    Shono, Ahmad N.

    2014-05-01

    This study contributes a methodology and associated toolkit developed to allow users to experiment with the use of combined features in classification problems. Methods are provided for efficiently generating combined features from an original feature set, for efficiently selecting the most discriminating of these generated combined features, and for efficiently performing a preliminary comparison of the classification results when using the original features exclusively against the results when using the selected combined features. The potential benefit of considering combined features in classification problems is demonstrated by applying the developed methodology and toolkit to three sample data sets where the discovery of combined features containing new discriminating information led to improved classification results.

  7. Improved lossless intra coding for next generation video coding

    Science.gov (United States)

    Vanam, Rahul; He, Yuwen; Ye, Yan

    2016-09-01

    Recently, there have been efforts by the ITU-T VCEG and ISO/IEC MPEG to further improve the compression performance of the High Efficiency Video Coding (HEVC) standard for developing a potential next generation video coding standard. The exploratory codec software of this potential standard includes new coding tools for inter and intra coding. In this paper, we present a new intra prediction mode for lossless intra coding. Our new intra mode derives a prediction filter for each input pixel using its neighboring reconstructed pixels, and applies this filter to the nearest neighboring reconstructed pixels to generate a prediction pixel. The proposed intra mode is demonstrated to improve the performance of the exploratory software for lossless intra coding, yielding a maximum and average bitrate savings of 4.4% and 2.11%, respectively.

  8. PROPOSAL FOR IMPROVEMENT OF BUINESS CONTINUITY PLAN (BCP) BASED ON THE LESSONS OF THE GREAT EAST JAPAN EARTHQUAKE

    Science.gov (United States)

    Maruya, Hiroaki

    For most Japanese companies and organizations, the enormous damage of the Great East Japan Earthquake was more than expected. In addition to great tsunami and earthquake motion, the lack of electricity and fuel disturbed to business activities seriously, and they should be considered important constraint factors in future earthquakes. Furthermore, disruption of supply chains also led considerable decline of production in many industries across Japan and foreign countries. Therefore it becomes urgent need for Japanese government and industries to utilize the lessons of the Great Earthquake and execute effective countermeasures, considering great earthquakes such as Tonankai & Nankai earthquakes and Tokyo Inland Earthquakes. Obviously most basic step is improving earthquake-resistant ability of buildings and facilities. In addition the spread of BCP and BCM to enterprises and organizations is indispensable. Based on the lessons, the BCM should include the point of view of the supply chain management more clearly, and emphasize "substitute strategy" more explicitly because a company should survive even if it completely loses its present production base. The central and local governments are requested, in addition to develop their own BCP, to improve related systematic conditions for BCM of the private sectors.

  9. Automatic Grasp Generation and Improvement for Industrial Bin-Picking

    DEFF Research Database (Denmark)

    Kraft, Dirk; Ellekilde, Lars-Peter; Rytz, Jimmy Alison

    2014-01-01

    This paper presents work on automatic grasp generation and grasp learning for reducing the manual setup time and increase grasp success rates within bin-picking applications. We propose an approach that is able to generate good grasps automatically using a dynamic grasp simulator, a newly developed...... and achieve comparable results and that our learning approach can improve system performance significantly. Automatic bin-picking is an important industrial process that can lead to significant savings and potentially keep production in countries with high labour cost rather than outsourcing it. The presented...... work allows to minimize cycle time as well as setup cost, which are essential factors in automatic bin-picking. It therefore leads to a wider applicability of bin-picking in industry....

  10. Greatly improved small inductance measurement using quartz crystal parasitic capacitance compensation.

    Science.gov (United States)

    Matko, Vojko; Jezernik, Karel

    2010-01-01

    Generally, quartz crystal inductance frequency pulling in oscillators is very low and therefore is not often used in practice. The new method of improving frequency pullability uses inductance to compensate for quartz stray capacitances. To this end, a special AT fundamental quartz crystal working near the antiresonance frequency is selected. By modifying its equivalent circuit with load inductance and series tuning capacitance, the magnetic sensing of the circuit can be highly improved. The experimental results show that the new approach using the quartz crystal stray capacitance compensation method increases the frequency pulling range (from ≅2 kHz/μH to ≅600 kHz/μH) by ×300 depending on the type of oscillator, making possible the measurement of nano-magnetic changes.

  11. Small Molecules Greatly Improve Conversion of Human-Induced Pluripotent Stem Cells to the Neuronal Lineage

    Directory of Open Access Journals (Sweden)

    Sally K. Mak

    2012-01-01

    Key success factors for neuronal differentiation are the yield of desired neuronal marker expression, reproducibility, length, and cost. Three main neuronal differentiation approaches are stromal-induced neuronal differentiation, embryoid body (EB differentiation, and direct neuronal differentiation. Here, we describe our neurodifferentiation protocol using small molecules that very efficiently promote neural induction in a 5-stage EB protocol from six induced pluripotent stem cells (iPSC lines from patients with Parkinson’s disease and controls. This protocol generates neural precursors using Dorsomorphin and SB431542 and further maturation into dopaminergic neurons by replacing sonic hedgehog with purmorphamine or smoothened agonist. The advantage of this approach is that all patient-specific iPSC lines tested in this study were successfully and consistently coaxed into the neural lineage.

  12. Generating Decision Trees Method Based on Improved ID3 Algorithm

    Institute of Scientific and Technical Information of China (English)

    Yang Ming; Guo Shuxu1; Wang Jun3

    2011-01-01

    The ID3 algorithm is a classical learning algorithm of decision tree in data mining.The algorithm trends to choosing the attribute with more values,affect the efficiency of classification and prediction for building a decision tree.This article proposes a new approach based on an improved ID3 algorithm.The new algorithm introduces the importance factor λ when calculating the information entropy.It can strengthen the label of important attributes of a tree and reduce the label of non-important attributes.The algorithm overcomes the flaw of the traditional ID3 algorithm which tends to choose the attributes with more values,and also improves the efficiency and flexibility in the process of generating decision trees.

  13. Cellulose nanowhiskers and fiber alignment greatly improve mechanical properties of electrospun prolamin protein fibers.

    Science.gov (United States)

    Wang, Yixiang; Chen, Lingyun

    2014-02-12

    Electrospun fibers from natural polymers must possess appropriate mechanical properties if they are to be functional in numerous applications. In this research, two convenient physical approaches were applied to reinforce the assembled hordein/zein electrospun nanofabrics: incorporation of surface-modified cellulose nanowhiskers (SCN) and fiber alignment. The mechanical properties and stability of the modified fibers were tested in relation to fiber morphology and structure as characterized by scanning electron microscopy, transmission electron microscopy, Fourier-transform infrared spectroscopy, and Raman spectroscopy. SCN modified by quaternary ammonium salt were well-dispersed in hordein/zein networks, leading to fibers with significantly improved mechanical properties and water resistance. With the addition of 3 wt % SCN, the tensile strength and Young's modulus of hordein/zein fibers increased from 4.36 ± 0.29 to 7.79 ± 0.36 MPa and from 195.80 ± 13.02 to 396.64 ± 18.33 MPa, respectively, and the elongation at break was retained because of the formation of a percolating network of SCN. The alignment of electrospun fibers strengthened the hordein/zein nanofabrics in both tangential and normal directions to 17.26 ± 1.41 and 14.02 ± 0.74 MPa, respectively, by not only altering the piling up pattern, but also by promoting phase separation and improved interactions. When applying both of the reinforcing methods, the tensile strength of hordein/zein fibers was further enhanced to 21.99 ± 1.19 MPa, stronger than that of cancellous bones (5-10 MPa). All the reinforced fibers exhibited a reduced burst effect in phosphate-buffered saline (PBS) while releasing the incorporated bioactive molecule in a controlled manner. These physically reinforced prolamin protein fibers possessed significantly improved mechanical properties and may have potential to be used as tissue engineering scaffold materials or natural delivery systems for biomedical applications.

  14. Greatly improved neuroprotective efficiency of citicoline by stereotactic delivery in treatment of ischemic injury.

    Science.gov (United States)

    Xu, Fangjingwei; Hongbin Han; Yan, Junhao; Chen, He; He, Qingyuan; Xu, Weiguo; Zhu, Ning; Zhang, Hong; Zhou, Fugen; Lee, Kejia

    2011-01-01

    Limited penetration of neuroprotective drug citicoline into the central nervous system (CNS) by systemic administration led to poor efficiency. A novel method of stereotactic drug delivery was explored to make citicoline bypass the blood brain barrier (BBB) and take effect by direct contact with ischemic neurons. A permanent middle cerebral artery occlusion (pMCAO) model of rats was prepared. To get the optimal conditions for citicoline administration by the novel stereotactic delivery pathway, magnetic resonance imaging (MRI) tracer method was used, and a dose-dependent effect was given. Examinations of MRI, behavior evaluation, infarct volume assessment and histological staining were performed to evaluate the outcome. This MRI-guided stereotactic delivery of citicoline resulted in a notable reduction (>80%) in infarct size and a delayed ischemic injury in cortex 12 hours after onset of acute ischemia when compared with the systematic delivery. The improved neuroprotective efficiency was realized by a full distribution of citicoline in most of middle cerebral artery (MCA) territory and an adequate drug reaction in the involved areas of the brain. Brain lesions of treated rats by stereotactic delivery of citicoline were well predicted in the lateral ventricle and thalamus due to a limited drug deposition by MRI tracer method. Our study realized an improved neuroprotective efficiency of citicoline by stereotactic delivery, and an optimal therapeutic effect of this administration pathway can be achieved under MRI guidance.

  15. A Synthesis of Characteristics of Submarine Landslides Generated by the 1964 Great Alaska Earthquake in Six Fjords

    Science.gov (United States)

    Haeussler, P. J.; Parsons, T.; Lee, H. J.; Ryan, H. F.; Brothers, D. S.; Liberty, L. M.; Hart, P. E.; Geist, E. L.; Roland, E. C.; Witter, R. C.; Kayen, R. E.

    2015-12-01

    Submarine landslide-generated tsunamis were the single largest cause of fatalities in the Mw9.2 1964 Great Alaska earthquake. In the last decade, we studied the submarine slope failures in six fjords: Resurrection Bay, Port Valdez, Passage Canal, southern Dangerous Passage, Aialik Bay, and Harris Bay. The six fjords lie 20 to 30 km above the Alaska-Aleutian megathrust, which provides an ideal landslide trigger mechanism. To characterize the landslides, we used multibeam bathymetry data, pre- and post-event bathymetry differencing, sparker and chirp seismic data, wave runup directions and heights, shear wave velocity profiles, the onland sedimentary record of the tsunamis, observations during the earthquake, and tsunami models. All slides originated at the margins of the fjords, mostly in unconsolidated sediment of the fjord-head deltas(?), and transported sediment to the deepest part of the fjords. The slides transported material up to ~15 km, resulting in slide deposits up to 20 m thick, and a subsequent megaturbidite deposit up to 15 m thick. These slides resurfaced the entire fjord bottom and the resultant flow of sediment and water brought numerous deep dwelling fish to the surface, killed by the sudden pressure changes. Typical fjord sedimentation resulted in conditions primed for slope failures. Fjord-head deltas deposited unconsolidated sediment at the upper margins of the fjords, which composed the majority of sediment that failed during the earthquake. We find that the highest tsunami runups were correlated with blocky landslides that required unique depositional conditions. The Little Ice Age (LIA) occurred between the penultimate megathrust earthquake ~900 yr ago and 1964, with the most recent maximum extent around 1875AD. The LIA glacial expansion led to significant sedimentation at the margins of the fjords. Near Shoup Bay in Port Valdez, in Passage Canal, and probably in southern Dangerous Passage, ice overrode till and sediment deposited in front of

  16. Modulation improvements in the 201 MHZ RF generators at LAMPF

    Energy Technology Data Exchange (ETDEWEB)

    Parsons, W M; Lyles, J T.M.; Harris, H W

    1992-01-01

    Radio-frequency generators, operating at 201 MHz, power the first four stages of the Los Alamos Meson Physics Facility (LAMPF) accelerator. Each generator consists of four stages of seriesconnected, vacuum-tube amplifiers. The modulation scheme for each stage is different. The fist amplifier is a grid-modulated tetrode that produces 500 W peak-power. The second amplifier is a drive-modulated tetrode that produces 5 kill peak-power. The third stage is a grid- and plate-modulated tetrode that produces 130 kill peak-power. The last stage is a plate-modulated triode that produces 2.5 MW peak power. A modernization program has been initiated to improve the reliability of each of these stages. The first two stages of each generator are being replaced with a single, drive-modulated, solid-state amplifier. Specifications for the amplifier design, and requirements for integration into the system are presented. The third stage will be converted to a drive-modulated system using the current tetrode. This modification involves the development of a 17-kV, 15-A switching supply to replace the present plate-modulator. Design requirements for this switching supply are presented. The final stage will remain plate-modulated but will contain a new driver unit for the modulator tube.

  17. Optimizing hyaluronidase dose and plasmid DNA delivery greatly improves gene electrotransfer efficiency in rat skeletal muscle

    DEFF Research Database (Denmark)

    Åkerström, Thorbjörn; Vedel, Kenneth; Needham Andersen, Josefine

    2015-01-01

    Transfection of rat skeletal muscle in vivo is a widely used research model. However, gene electrotransfer protocols have been developed for mice and yield variable results in rats. We investigated whether changes in hyaluronidase pre-treatment and plasmid DNA delivery can improve transfection...... efficiency in rat skeletal muscle. We found that pre-treating the muscle with a hyaluronidase dose suitable for rats (0.56. U/g b.w.) prior to plasmid DNA injection increased transfection efficiency by >200% whereas timing of the pre-treatment did not affect efficiency. Uniformly distributing plasmid DNA...... delivery across the muscle by increasing the number of plasmid DNA injections further enhanced transfection efficiency whereas increasing plasmid dose from 0.2 to 1.6. μg/g b.w. or vehicle volume had no effect. The optimized protocol resulted in ~80% (CI95%: 79-84%) transfected muscle fibers...

  18. Second-generation aerosol shock tube: an improved design

    Science.gov (United States)

    Haylett, D. R.; Davidson, D. F.; Hanson, R. K.

    2012-11-01

    An improved, second-generation aerosol shock tube (AST II) has been developed for the study of the chemical kinetics of low-vapor-pressure fuels. These improvements enable a wider range of fuel concentrations and enhanced spatial uniformity relative to our initial aerosol shock tube (AST I). In addition, the design of AST II limits the aerosol loading zone in the shock tube to a fixed region (1.2 m in length adjacent to the shock tube endwall). AST II achieves these improvements using a separate holding tank to prepare the aerosol mixture and a slightly under-pressure dump tank to carefully pull the aerosol mixture into the tube in a plug-flow. This filling method is capable of producing room temperature test gas mixtures of n-dodecane with equivalence ratios of up to 3.0 in 21 % O2, three times the loading achievable in the earlier AST I that used a flow-through strategy. Improvements in aerosol uniformity were quantified by measuring the liquid volume concentration at multiple locations in the shock tube. The measurements made over a length of 1.1 m of shock tube indicate that the AST II method of filling produces non-uniformities in liquid volume concentration of less than 2 %, whereas in the AST I method of filling the non-uniformities reached 16 %. The improved uniformity can also be seen in measurement of gas-phase fuel concentration behind the incident shock wave after the liquid droplets have evaporated. Significant reduction in the scatter of ignition delay times measured using AST II have also been achieved, confirming the importance of uniform loading of the aerosol in making high-quality combustion measurements.

  19. Good to great: using 360-degree feedback to improve physician emotional intelligence.

    Science.gov (United States)

    Hammerly, Milton E; Harmon, Larry; Schwaitzberg, Steven D

    2014-01-01

    The past decade has seen intense interest and dramatic change in how hospitals and physician organizations review physician behaviors. The characteristics of successful physicians extend past their technical and cognitive skills. Two of the six core clinical competencies (professionalism and interpersonal/communication skills) endorsed by the Accreditation Council for Graduate Medical Education, the American Board of Medical Specialties, and The Joint Commission require physicians to succeed in measures associated with emotional intelligence (EI). Using 360-degree anonymous feedback surveys to screen for improvement opportunities in these two core competencies enables organizations to selectively offer education to further develop physician EI. Incorporating routine use of these tools and interventions into ongoing professional practice evaluation and focused professional practice evaluation processes may be a cost-effective strategy for preventing disruptive behaviors and increasing the likelihood of success when transitioning to an employed practice model. On the basis of a literature review, we determined that physician EI plays a key role in leadership; teamwork; and clinical, financial, and organizational outcomes. This finding has significant implications for healthcare executives seeking to enhance physician alignment and transition to a team-based delivery model.

  20. Complete exon sequencing of all known Usher syndrome genes greatly improves molecular diagnosis

    Directory of Open Access Journals (Sweden)

    Lacombe Didier

    2011-05-01

    Full Text Available Abstract Background Usher syndrome (USH combines sensorineural deafness with blindness. It is inherited in an autosomal recessive mode. Early diagnosis is critical for adapted educational and patient management choices, and for genetic counseling. To date, nine causative genes have been identified for the three clinical subtypes (USH1, USH2 and USH3. Current diagnostic strategies make use of a genotyping microarray that is based on the previously reported mutations. The purpose of this study was to design a more accurate molecular diagnosis tool. Methods We sequenced the 366 coding exons and flanking regions of the nine known USH genes, in 54 USH patients (27 USH1, 21 USH2 and 6 USH3. Results Biallelic mutations were detected in 39 patients (72% and monoallelic mutations in an additional 10 patients (18.5%. In addition to biallelic mutations in one of the USH genes, presumably pathogenic mutations in another USH gene were detected in seven patients (13%, and another patient carried monoallelic mutations in three different USH genes. Notably, none of the USH3 patients carried detectable mutations in the only known USH3 gene, whereas they all carried mutations in USH2 genes. Most importantly, the currently used microarray would have detected only 30 of the 81 different mutations that we found, of which 39 (48% were novel. Conclusions Based on these results, complete exon sequencing of the currently known USH genes stands as a definite improvement for molecular diagnosis of this disease, which is of utmost importance in the perspective of gene therapy.

  1. Incorporating polyoxometalates into a porous MOF greatly improves its selective adsorption of cationic dyes.

    Science.gov (United States)

    Yan, Ai-Xue; Yao, Shuang; Li, Yang-Guang; Zhang, Zhi-Ming; Lu, Ying; Chen, Wei-Lin; Wang, En-Bo

    2014-06-02

    Various polyoxometalates (POMs) were successfully immobilized to the mesoporous coordination polymer MIL-101 resulting in a series of POM-MOF composite materials POM@MIL-101 (POM = K4PW11VO40, H3PW12O40, K4SiW12O40). These materials were synthesized by a simple one-pot reaction of Keggin POMs, tetramethylammonium hydroxide (TMAH), terephthalic acid (H2bdc), and Cr(3+) ions. XRD, FTIR, thermogravimetric analyses (TG), inductively coupled plasma (ICP) spectrometry, and energy-dispersive X-ray spectroscopy (EDX) collectively confirmed the successful combination of POMs and the porous framework. Further, these composites POM@MIL-101 with different loading of POMs were achieved by variation of the POM dosage. Notably, the uptake capacity of MIL-101 towards organic pollutants in aqueous solution was significantly improved by immobilization of hydrophilic POMs into cages of MIL-101. An uptake capacity of 371 mg g(-1), comparable to that of the graphene oxide sponges, and much higher than that of the commercial activated carbon, was achieved at room temperature in 5 min when dipping 20 mg PW11V@MIL-101 in the methylene blue (MB) solution (100 mL of 100 mg L(-1) MB solution). Further study revealed that the POM@MIL-101 composite materials not only exhibited a fast adsorption rate towards dye molecules, but also possessed of selective adsorption ability of the cationic dyes in wastewater. For example, the adsorption efficiency of PW11V@MIL-101 (10 mg) towards MB (100 mL of 10 mg L(-1)) could reach 98 % in the initial 5 min, and it could capture MB dye molecules from the binary mixture of the MB and MO with similar size. Also, the POM@MIL-101 materials could be readily recycled and reused, and no POM leached in the dye adsorption process. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  2. Big Ship Data: Using vessel measurements to improve estimates of temperature and wind speed on the Great Lakes

    Science.gov (United States)

    Fries, Kevin; Kerkez, Branko

    2017-05-01

    The sheer size of many water systems challenges the ability of in situ sensor networks to resolve spatiotemporal variability of hydrologic processes. New sources of vastly distributed and mobile measurements are, however, emerging to potentially fill these observational gaps. This paper poses the question: How can nontraditional measurements, such as those made by volunteer ship captains, be used to improve hydrometeorological estimates across large surface water systems? We answer this question through the analysis of one of the largest such data sets: an unprecedented collection of one million unique measurements made by ships on the North American Great Lakes from 2006 to 2014. We introduce a flexible probabilistic framework, which can be used to integrate ship measurements, or other sets of irregular point measurements, into contiguous data sets. The performance of this framework is validated through the development of a new ship-based spatial data product of water temperature, air temperature, and wind speed across the Great Lakes. An analysis of the final data product suggests that the availability of measurements across the Great Lakes will continue to play a large role in the confidence with which these large surface water systems can be studied and modeled. We discuss how this general and flexible approach can be applied to similar data sets, and how it will be of use to those seeking to merge large collections of measurements with other sources of data, such as physical models or remotely sensed products.

  3. Clean Diesel Engine Component Improvement Program Diesel Truck Thermoelectric Generator

    Energy Technology Data Exchange (ETDEWEB)

    Elsner, N. B. [Hi-Z Technology, Inc., San Diego, CA (United States); Bass, J. C. [Hi-Z Technology, Inc., San Diego, CA (United States); Ghamaty, S. [Hi-Z Technology, Inc., San Diego, CA (United States); Krommenhoek, D. [Hi-Z Technology, Inc., San Diego, CA (United States); Kushch, A. [Hi-Z Technology, Inc., San Diego, CA (United States); Snowden, D. [Hi-Z Technology, Inc., San Diego, CA (United States); Marchetti, S. [Hi-Z Technology, Inc., San Diego, CA (United States)

    2005-03-16

    Hi-Z Technology, Inc. (Hi-Z) is currently developing four different auxiliary generator designs that are used to convert a portion (5 to 20%) of the waste heat from vehicle engines exhaust directly to electricity. The four designs range from 200 Watts to 10 kW. The furthest along is the 1 kW Diesel Truck Thermoelectric Generator (DTTEG) for heavy duty Class 8 Diesel trucks, which, under this program, has been subjected to 543,000 equivalent miles of bouncing and jarring on PACCAR's test track. Test experience on an earlier version of the DTTEG on the same track showed the need for design modifications incorporated in DTTEG Mod 2, such as a heavy duty shock mounting system and reinforcement of the electrical leads mounting system, the thermocouple mounting system and the thermoelectric module restraints. The conclusion of the 543,000 mile test also pointed the way for an upgrading to heavy duty hose or flex connections for the internal coolant connections for the TEG, and consideration of a separate lower temperature cooling loop with its own radiator. Fuel savings of up to $750 per year and a three to five year payback are believed to be possible with the 5 % efficiency modules. The economics are expected to improve considerably to approach a two year payback when the 5 kW to 10 kW generators make it to the market in a few years with a higher efficiency (20%) thermoelectric module system called Quantum Wells, which are currently under development by Hi-Z. Ultimately, as automation takes over to reduce material and labor costs in the high volume production of QW modules, a one year payback for the 5 kW to10 kW generator appears possible. This was one of the stated goals at the beginning of the project. At some future point in time, with the DTTEG becoming standard equipment on all trucks and automobiles, fuel savings from the 25% conversion of exhaust heat to useable electricity nationwide equates to a 10% reduction in the 12 to 15 million barrels per day of

  4. Improved inertial control for permanent magnet synchronous generator wind turbine generators

    Energy Technology Data Exchange (ETDEWEB)

    Wu, Ziping; Gao, Wenzhong; Wang, Xiao; Kang, Moses; Hwang, Min; Kang, Yong Cheol; Gevogian, Vahan; Muljadi, Eduard

    2016-05-31

    With increasing integrations of large-scale systems based on permanent magnet synchronous generator wind turbine generators (PMSG-WTGs), the overall inertial response of a power system will tend to deteriorate as a result of the decoupling of rotor speed and grid frequency through the power converter as well as the scheduled retirement of conventional synchronous generators. Thus, PMSG-WTGs can provide value to an electric grid by contributing to the system's inertial response through the inherent kinetic energy stored in their rotating masses and fast power converter control. In this study, an improved inertial control method based on the maximum power point tracking operation curve is introduced to enhance the overall frequency support capability of PMSG-WTGs in the case of large supply-demand imbalances. Moreover, this method is implemented in the CART2-PMSG integrated model in MATLAB/Simulink to investigate its impact on the wind turbine's structural loads during the inertial response process. Simulation results indicate that the proposed method can effectively reduce the frequency nadir, arrest the rate of change of frequency, and alleviate the secondary frequency dip while imposing no negative impact on the major mechanical components of the wind turbine.

  5. Great Lakes Integrated Sciences + Assessments: Connecting Users and Generators of Scientific Information to Inform Climate Change Adaptation

    Science.gov (United States)

    Baule, W. J.; Briley, L.; Brown, D.; Gibbons, E.

    2014-12-01

    The Great Lakes Integrated Sciences + Assessments (GLISA) is one of eleven NOAA Regional Integrated Sciences and Assessments (RISAs) and is a co-hosted by the University of Michigan and Michigan State University. The Great Lakes region falls between areas that are typically defined as the Midwest and Northeast in the United States and also includes portions of Ontario in Canada. This unique and complex region holds approximately 21% of global surface fresh water and is home to 23 million people on the United States side of the basin alone. GLISA functions as a bridge between climate science researchers and boundary organizations in the Great Lakes region, with the goals of contributing to the long-term sustainability of the region in face of a changing climate and to facilitate smart decision-making backed by sound scientific knowledge. Faculty and staff associated with GLISA implement physical and social science practices in daily operations, which includes but is not limited to: activating the boundary chain model to facilitate the transfer of knowledge through the community, integrating local and historical climate data into decision-making processes, addressing uncertainty and the downscaling of climate information, and implementing network analyses to find key access points to information networks across the Great Lakes region. GLISA also provides funding for projects related to climate and climate change adaptation in the Great Lakes region, as well as expertise to partner organizations through collaborations. Information from boundary organizations, stakeholders, and collaborators also flows back to GLISA to aid in the determination of the physical and social science needs of the region. Recent findings point to GLISA playing a crucial role in the scaling information across scales of government and ensuring that federal agencies and local stakeholders are able to learn from one another and share experiences and knowledge to continue building climate ready

  6. Frequent Questions about the Hazardous Waste Generator Improvements Final Rule

    Science.gov (United States)

    FAQs including What are the benefits of these revisions to the generator regulations? What changed in the final regulations since proposal? How and why will the hazardous waste generator regulations be reorganized? When will this rule become effective?

  7. Technical Advance: a new cell preparation strategy that greatly improves the yield of vital and functional Tregs and NKT cells.

    Science.gov (United States)

    Rissiek, Björn; Danquah, Welbeck; Haag, Friedrich; Koch-Nolte, Friedrich

    2014-03-01

    Release of NAD(+) during preparation of murine lymphocytes causes enzymatic ADP-ribosylation of cell-surface proteins on T cells, catalyzed by toxin-related ecto-ADP-ribosyltransferase, ARTC2. ADP-riboslyation activates the cytolytic P2X7 ion channel and affects, in particular, the vitality and function of Tregs and NKT cells. Here, we describe a simple method-injection of an ARTC2-blocking nanobody-to greatly improve Treg and NKT cell vitality and to preserve their function during in vitro assays and in adoptive-transfer experiments. Moreover, we present a method for the sorting of functional, primary NKT cells, based on coexpression of ARTC2 and NK1.1. Our results pave the way for the efficient ex vivo proliferation of Tregs and NKT cells and for new experimental and therapeutic uses of these important regulatory cells.

  8. Improved Methods For Generating Quasi-Gray Codes

    CERN Document Server

    Jansens, Dana; Carmi, Paz; Maheshwari, Anil; Morin, Pat; Smid, Michiel

    2010-01-01

    Consider a sequence of bit strings of length d, such that each string differs from the next in a constant number of bits. We call this sequence a quasi-Gray code. We examine the problem of efficiently generating such codes, by considering the number of bits read and written at each generating step, the average number of bits read while generating the entire code, and the number of strings generated in the code. Our results give a trade-off between these constraints, and present algorithms that do less work on average than previous results, and that increase the number of bit strings generated.

  9. Next Generation Surfactants for Improved Chemical Flooding Technology

    Energy Technology Data Exchange (ETDEWEB)

    Laura Wesson; Prapas Lohateeraparp; Jeffrey Harwell; Bor-Jier Shiau

    2012-05-31

    The principle objective of this project was to characterize and test current and next generation high performance surfactants for improved chemical flooding technology, focused on reservoirs in the Pennsylvanian-aged (Penn) sands. In order to meet this objective the characteristic curvatures (Cc) of twenty-eight anionic surfactants selected for evaluation for use in chemical flooding formulations were determined. The Cc values ranged from -6.90 to 2.55 with the majority having negative values. Crude oil samples from nine Penn sand reservoirs were analyzed for several properties pertinent to surfactant formulation for EOR application. These properties included equivalent alkane carbon numbers, total acid numbers, and viscosity. The brine samples from these same reservoirs were analyzed for several cations and for total dissolved solids. Surfactant formulations were successfully developed for eight reservoirs by the end of the project period. These formulations were comprised of a tertiary mixture of anionic surfactants. The identities of these surfactants are considered proprietary, but suffice to say the surfactants in each mixture were comprised of varying chemical structures. In addition to the successful development of surfactant formulations for EOR, there were also two successful single-well field tests conducted. There are many aspects that must be considered in the development and implementation of effective surfactant formulations. Taking into account these other aspects, there were four additional studies conducted during this project. These studies focused on the effect of the stability of surfactant formulations in the presence of polymers with an associated examination of polymer rheology, the effect of the presence of iron complexes in the brine on surfactant stability, the potential use of sacrificial agents in order to minimize the loss of surfactant to adsorption, and the effect of electrolytes on surfactant adsorption. In these last four studies

  10. Fact Sheet About the Hazardous Waste Generator Improvements Final Rule

    Science.gov (United States)

    October 28, 2016, EPA finalized a rule that revises the hazardous waste generator regulations by making them easier to understand and providing greater flexibility in how hazardous waste is managed to better fit today's business operations.

  11. Close look at eight great energy myths with particular attention to the generation and use of electricity

    Energy Technology Data Exchange (ETDEWEB)

    None

    1982-05-01

    This paper is to assess implications for the generation and use of electricity. Projections are compared with others prepared by the Energy Information Administration, DOE's Office of Policy, Planning and Analysis, and Energy and Environmental Analysis, Inc. Major differences in method, inputs, and results are identified, and to the extent possible, explained. Section II is a general summary of the review, and presents principal assumptions, methods, results, and major conclusions. Sections III, IV and V provide more detail to trace the analysis more closely. Section III, for example discusses some fundamental criticisms of the conceptual approach. Section IV, in contrast, accepts the basic framework but raises certain criticisms of the analysis within that framework. Section V discusses the treatment of electric generation in this paper, and probes the implications of the results.

  12. KSR-based medium improves the generation of high-quality mouse iPS cells.

    Science.gov (United States)

    Liu, Kai; Wang, Fang; Ye, Xiaoying; Wang, Lingling; Yang, Jiao; Zhang, Jingzhuo; Liu, Lin

    2014-01-01

    Induced pluripotent stem (iPS) cells from somatic cells have great potential for regenerative medicine. The efficiency in generation of iPS cells has been significantly improved in recent years. However, the generation of high-quality iPS cells remains of high interest. Consistently, we demonstrate that knockout serum replacement (KSR)-based medium accelerates iPS cell induction and improves the quality of iPS cells, as confirmed by generation of chimeras and all iPS cell-derived offspring with germline transmission competency. Both alkaline phosphatase (AP) activity assay and expression of Nanog have been used to evaluate the efficiency of iPS cell induction and formation of ES/iPS cell colonies; however, appropriate expression of Nanog frequently indicates the quality of ES/iPS cells. Interestingly, whereas foetal bovine serum (FBS)-based media increase iPS cell colony formation, as revealed by AP activity, KSR-based media increase the frequency of iPS cell colony formation with Nanog expression. Furthermore, inhibition of MAPK/ERK by a specific inhibitor, PD0325901, in KSR- but not in FBS-based media significantly increases Nanog-GFP+ iPS cells. In contrast, addition of bFGF in KSR-based media decreases proportion of Nanog-GFP+ iPS cells. Remarkably, PD can rescue Nanog-GFP+ deficiency caused by bFGF. These data suggest that MAPK/ERK pathway influences high quality mouse iPS cells and that KSR- and PD-based media could enrich homogeneous authentic pluripotent stem cells.

  13. Eocene extension in Idaho generated massive sediment floods into Franciscan trench and into Tyee, Great Valley, and Green River basins

    Science.gov (United States)

    Dumitru, Trevor A.; Ernst, W.G.; Wright, James E.; Wooden, Joseph L.; Wells, Ray E.; Farmer, Lucia P.; Kent, Adam J.R.; Graham, Stephan A.

    2013-01-01

    The Franciscan Complex accretionary prism was assembled during an ∼165-m.y.-long period of subduction of Pacific Ocean plates beneath the western margin of the North American plate. In such fossil subduction complexes, it is generally difficult to reconstruct details of the accretion of continent-derived sediments and to evaluate the factors that controlled accretion. New detrital zircon U-Pb ages indicate that much of the major Coastal belt subunit of the Franciscan Complex represents a massive, relatively brief, surge of near-trench deposition and accretion during Eocene time (ca. 53–49 Ma). Sediments were sourced mainly from the distant Idaho Batholith region rather than the nearby Sierra Nevada. Idaho detritus also fed the Great Valley forearc basin of California (ca. 53–37 Ma), the Tyee forearc basin of coastal Oregon (49 to ca. 36 Ma), and the greater Green River lake basin of Wyoming (50–47 Ma). Plutonism in the Idaho Batholith spanned 98–53 Ma in a contractional setting; it was abruptly superseded by major extension in the Bitterroot, Anaconda, Clearwater, and Priest River metamorphic core complexes (53–40 Ma) and by major volcanism in the Challis volcanic field (51–43 Ma). This extensional tectonism apparently deformed and uplifted a broad region, shedding voluminous sediments toward depocenters to the west and southeast. In the Franciscan Coastal belt, the major increase in sediment input apparently triggered a pulse of massive accretion, a pulse ultimately controlled by continental tectonism far within the interior of the North American plate, rather than by some tectonic event along the plate boundary itself.

  14. A Maximum Power Tracker for Improved Thermophotovoltaic Power Generation Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Radioisotope Power Systems (RPS) are critical for future flagship exploration missions in space and on planetary surfaces. Small improvements in the RPS performance,...

  15. Automating methods to improve precision in Monte-Carlo event generation for particle colliders

    Energy Technology Data Exchange (ETDEWEB)

    Gleisberg, Tanju

    2008-07-01

    The subject of this thesis was the development of tools for the automated calculation of exact matrix elements, which are a key for the systematic improvement of precision and confidence for theoretical predictions. Part I of this thesis concentrates on the calculations of cross sections at tree level. A number of extensions have been implemented in the matrix element generator AMEGIC++, namely new interaction models such as effective loop-induced couplings of the Higgs boson with massless gauge bosons, required for a number of channels for the Higgs boson search at LHC and anomalous gauge couplings, parameterizing a number of models beyond th SM. Further a special treatment to deal with complicated decay chains of heavy particles has been constructed. A significant effort went into the implementation of methods to push the limits on particle multiplicities. Two recursive methods have been implemented, the Cachazo-Svrcek-Witten recursion and the colour dressed Berends-Giele recursion. For the latter the new module COMIX has been added to the SHERPA framework. The Monte-Carlo phase space integration techniques have been completely revised, which led to significantly reduced statistical error estimates when calculating cross sections and a greatly improved unweighting efficiency for the event generation. Special integration methods have been developed to cope with the newly accessible final states. The event generation framework SHERPA directly benefits from those new developments, improving the precision and the efficiency. Part II was addressed to the automation of QCD calculations at next-to-leading order. A code has been developed, that, for the first time fully automates the real correction part of a NLO calculation. To calculate the correction for a m-parton process obeying the Catani-Seymour dipole subtraction method the following components are provided: 1. the corresponding m+1-parton tree level matrix elements, 2. a number dipole subtraction terms to remove

  16. Arbitrary waveform generator to improve laser diode driver performance

    Science.gov (United States)

    Fulkerson, Jr, Edward Steven

    2015-11-03

    An arbitrary waveform generator modifies the input signal to a laser diode driver circuit in order to reduce the overshoot/undershoot and provide a "flat-top" signal to the laser diode driver circuit. The input signal is modified based on the original received signal and the feedback from the laser diode by measuring the actual current flowing in the laser diode after the original signal is applied to the laser diode.

  17. Hypothesis Generation in Quality Improvement Projects: Approaches for Exploratory Studies

    NARCIS (Netherlands)

    de Mast, J.; Bergman, M.

    2006-01-01

    In quality improvement projects - such as Six Sigma projects - an exploratory phase can be discerned, during which possible causes, influence factors or variation sources are identified. In a subsequent confirmatory phase the effects of these possible causes are experimentally verified. Whereas the

  18. Explanation Generation, Not Explanation Expectancy, Improves Metacomprehension Accuracy

    Science.gov (United States)

    Fukaya, Tatsushi

    2013-01-01

    The ability to monitor the status of one's own understanding is important to accomplish academic tasks proficiently. Previous studies have shown that comprehension monitoring (metacomprehension accuracy) is generally poor, but improves when readers engage in activities that access valid cues reflecting their situation model (activities such as…

  19. Investment Strategies for Improving Fifth-Generation Fighter Training

    Science.gov (United States)

    2011-01-01

    rOCA -DEAD rOCA ...Escort rOCA -SAT rOCA -Sweep rGS rRA / ratio Mission to red air ratio / 1v0 2v1 1v1 1v2 1v3 1v4 / envir Environments / SAsim DMO local LFE / live(envir...Generation Fighter Training sortXmisn(“rINS”,“mINS”,ratio,envir) = 1; sortXmisn(“ rOCA -DEAD”,“mOCA-DEAD”,ratio,envir) = 1; sortXmisn(“ rOCA

  20. Improving Semi-Supervised Learning with Auxiliary Deep Generative Models

    DEFF Research Database (Denmark)

    Maaløe, Lars; Sønderby, Casper Kaae; Sønderby, Søren Kaae

    Deep generative models based upon continuous variational distributions parameterized by deep networks give state-of-the-art performance. In this paper we propose a framework for extending the latent representation with extra auxiliary variables in order to make the variational distribution more...... expressive for semi-supervised learning. By utilizing the stochasticity of the auxiliary variable we demonstrate how to train discriminative classifiers resulting in state-of-the-art performance within semi-supervised learning exemplified by an 0.96% error on MNIST using 100 labeled data points. Furthermore...

  1. Improvements on the third generation of electron momentum spectrometer

    Institute of Scientific and Technical Information of China (English)

    Ning Chuan-Cang; Zhang Shu-Feng; Deng Jing-Kang; Liu Kun; Huang Yan-Ru; Luo Zhi-Hong

    2008-01-01

    The significant modifications to our recently constructed electron momentum spectrometer have been implemented.Compared with our previous report,the energy and the angle resolutions are significantly improved and reach △E=0.45 eV,△θ=±0.53°and △φ=±0.84°,respectively.Moreover,the details of data reduction and the relation between azimuthal angle range and the sensitivity are discussed.

  2. Accuracy Feedback Improves Word Learning from Context: Evidence from a Meaning-Generation Task

    Science.gov (United States)

    Frishkoff, Gwen A.; Collins-Thompson, Kevyn; Hodges, Leslie; Crossley, Scott

    2016-01-01

    The present study asked whether accuracy feedback on a meaning generation task would lead to improved contextual word learning (CWL). Active generation can facilitate learning by increasing task engagement and memory retrieval, which strengthens new word representations. However, forced generation results in increased errors, which can be…

  3. Forecasting Wind and Solar Generation: Improving System Operations, Greening the Grid (Spanish Version)

    Energy Technology Data Exchange (ETDEWEB)

    Tian, Tian; Chernyakhovskiy, Ilya; Brancucci Martinez-Anido, Carlo

    2016-04-01

    This document is the Spanish version of 'Greening the Grid- Forecasting Wind and Solar Generation Improving System Operations'. It discusses improving system operations with forecasting with and solar generation. By integrating variable renewable energy (VRE) forecasts into system operations, power system operators can anticipate up- and down-ramps in VRE generation in order to cost-effectively balance load and generation in intra-day and day-ahead scheduling. This leads to reduced fuel costs, improved system reliability, and maximum use of renewable resources.

  4. Forecasting Wind and Solar Generation: Improving System Operations, Greening the Grid

    Energy Technology Data Exchange (ETDEWEB)

    Tian; Tian; Chernyakhovskiy, Ilya

    2016-01-01

    This document discusses improving system operations with forecasting and solar generation. By integrating variable renewable energy (VRE) forecasts into system operations, power system operators can anticipate up- and down-ramps in VRE generation in order to cost-effectively balance load and generation in intra-day and day-ahead scheduling. This leads to reduced fuel costs, improved system reliability, and maximum use of renewable resources.

  5. An improved superoxide-generating nanodevice for oxidative stress studies in cultured cells

    Directory of Open Access Journals (Sweden)

    Minoru Tamura

    2015-06-01

    Full Text Available The effects of reactive oxygen species on cells have attracted great attention from both physiological and pathological aspects. Superoxide (O2− is the primary reactive oxygen species formed in animals. We previously developed an O2−-generating nanodevice consisting of NADPH oxidase 2 (Nox2 and modulated activating factors. However, the device was subsequently found to be unstable in a standard culture medium. Here we improved the device in stability by cross-linking. This new nanodevice, Device II, had a half-life of 3 h at 37 °C in the medium. Device II induced cell death in 80% of HEK293 cells after 24 h of incubation. Superoxide dismutase alone did not diminish the effect of the device, but eliminated the effect when used together with catalase, confirming that the cell death was caused by H2O2 derived from O2−. Flow cytometric analyses revealed that Device II induced caspase-3 activation in HEK293 cells, suggesting that the cell death proceeded largely through apoptosis.

  6. Using MapReduce to Improve the Power Generation of the International Space Station

    Science.gov (United States)

    Marchetto, William R., II

    The International Space Station (ISS) spends approximately 98% of its time in orbits that experience Earth eclipse. Since the station's solar arrays produce no power when in Earth's shadow, the total power generated decreases substantially, lowering the power budget available to experimental payloads. Therefore, increasing the power output during these eclipsed orbits would be of great benefit to the space station's scientific endeavors. The ISS's current solar array configuration tracks the Sun throughout each orbit, keeping each of its 16 solar panels perpendicular to the Sun at all times. While this is the optimal orientation for solar panels with unobstructed views of the Sun, the space station's solar arrays experience shadowing from the spacecraft's structure as well as from the other solar panels. Deviating from the Sun-tracking scheme at strategic points in certain orbits can provide an increase in power output. The goal of this research was to provide a programmatic solution that increases the power generation capabilities of the ISS in orbits experiencing Earth-eclipse without requiring any physical modifications to the space station's structure. To achieve this goal, a simulator was developed to model the ISS-Earth-Sun environment and calculate the power output of the station's solar arrays based on each panel's orientation and shadowing. Many combinations of array configurations were analyzed, taking into account the physical constraints of the gimbals responsible for rotating the solar panels. The power output of the ISS was improved for the subset of Earth-eclipsed orbits that experience a high degree of shadowing from the station's structure, resulting in an average energy increase of 1.08 kWh per orbit. The power gains were achieved by quickly rotating the solar arrays through the points in each orbit that experienced the highest degree of shadowing.

  7. Stress-inducible expression of AtDREB1A transcription factor greatly improves drought stress tolerance in transgenic indica rice.

    Science.gov (United States)

    Ravikumar, G; Manimaran, P; Voleti, S R; Subrahmanyam, D; Sundaram, R M; Bansal, K C; Viraktamath, B C; Balachandran, S M

    2014-06-01

    The cultivation of rice (Oryza sativa L.), a major food crop, requires ample water (30 % of the fresh water available worldwide), and its productivity is greatly affected by drought, the most significant environmental factor. Much research has focussed on identifying quantitative trait loci, stress-regulated genes and transcription factors that will contribute towards the development of climate-resilient/tolerant crop plants in general and rice in particular. The transcription factor DREB1A, identified from the model plant Arabidopsis thaliana, has been reported to enhance stress tolerance against drought stress. We developed transgenic rice plants with AtDREB1A in the background of indica rice cultivar Samba Mahsuri through Agrobacterium-mediated transformation. The AtDREB1A gene was stably inherited and expressed in T1 and T2 plants and in subsequent generations, as indicated by the results of PCR, Southern blot and RT-PCR analyses. Expression of AtDREB1A was induced by drought stress in transgenic rice lines, which were highly tolerant to severe water deficit stress in both the vegetative and reproductive stages without affecting their morphological or agronomic traits. The physiological studies revealed that the expression of AtDREB1A was associated with an increased accumulation of the osmotic substance proline, maintenance of chlorophyll, increased relative water content and decreased ion leakage under drought stress. Most of the homozygous lines were highly tolerant to drought stress and showed significantly a higher grain yield and spikelet fertility relative to the nontransgenic control plants under both stressed and unstressed conditions. The improvement in drought stress tolerance in combination with agronomic traits is very essential in high premium indica rice cultivars, such as Samba Mahsuri, so that farmers can benefit in times of seasonal droughts and water scarcity.

  8. Voltage Stability Improvement of Grid Connected Wind Driven Induction Generator Using Svc

    Directory of Open Access Journals (Sweden)

    Ruchi Aggarwal

    2014-05-01

    Full Text Available Voltage stability is one of the major problem associated with wind power generating system which may be due to fluctuating nature of wind, heavy load, fault occurrence or insufficient reactive power supply. The wind power generating system most commonly employed with squirrel cage induction generator(SCIG that needs the support of an external device such as capacitor bank, FACTS devices etc. to support reactive power in order to remain connected with the grid during voltage dips. The voltage stability of a wind driven induction generator can be improved by using FACTS devices such as SVC, STATCOM.In this paper svc is used for voltage stability improvement.

  9. Advanced Direct-Drive Generator for Improved Availability of Oscillating Wave Surge Converter Power Generation Systems Final Technical Report

    Energy Technology Data Exchange (ETDEWEB)

    Englebretson, Steven [ABB Inc., Cary, NC (United States); Ouyang, Wen [ABB Inc., Cary, NC (United States); Tschida, Colin [ABB Inc., Cary, NC (United States); Carr, Joseph [ABB Inc., Cary, NC (United States); Ramanan, V.R. [ABB Inc., Cary, NC (United States); Johnson, Matthew [Texas A& M Univ., College Station, TX (United States); Gardner, Matthew [Texas A& M Univ., College Station, TX (United States); Toliyat, Hamid [Texas A& M Univ., College Station, TX (United States); Staby, Bill [Resolute Marine Energy, Inc., Boston, MA (United States); Chertok, Allan [Resolute Marine Energy, Inc., Boston, MA (United States); Hazra, Samir [ABB Inc., Cary, NC (United States); Bhattacharya, Subhashish [ABB Inc., Cary, NC (United States)

    2017-05-13

    This report summarizes the activities conducted under the DOE-EERE funded project DE-EE0006400, where ABB Inc. (ABB), in collaboration with Texas A&M’s Advanced Electric Machines & Power Electronics (EMPE) Lab and Resolute Marine Energy (RME) designed, derisked, developed, and demonstrated a novel magnetically geared electrical generator for direct-drive, low-speed, high torque MHK applications The project objective was to investigate a novel and compact direct-drive electric generator and its system aspects that would enable elimination of hydraulic components in the Power Take-Off (PTO) of a Marine and Hydrokinetic (MHK) system with an oscillating wave surge converter (OWSC), thereby improving the availability of the MHK system. The scope of this project was limited to the development and dry lab demonstration of a low speed generator to enable future direct drive MHK systems.

  10. Improved method of generating bit reversed numbers for calculating fast fourier transform

    Digital Repository Service at National Institute of Oceanography (India)

    Suresh, T.

    Fast Fourier Transform (FFT) is an important tool required for signal processing in defence applications. This paper reports an improved method for generating bit reversed numbers needed in calculating FFT using radix-2. The refined algorithm takes...

  11. Pseudorandom Number Generators for Mobile Devices: An Examination and Attempt to Improve Randomness

    Science.gov (United States)

    2013-09-01

    the positions but how the m- sequences (shaded) are equal. Also note how in the Fibonacci LSFR the sequences at the different positions are the...improve the random properties of the output m- sequence of linear feedback shift registers. A couple of possible attacks on pseudorandom number generators...generator normally used to improve the random properties of the output m- sequence of linear feedback shift registers. A couple of possible attacks on

  12. 一代国乐大师刘天华%Liu Tian-hua:A Great Master of Traditional Chinese Music in the Generation

    Institute of Scientific and Technical Information of China (English)

    秦太明

    2012-01-01

    Liu Tian-hua was a great master of traditional Chinese music with his outstanding contributions to modern Chinese music instrument playing, he devoted all his life to innovating traditional Chinese music, opened up a brand-new arena to erhu(a kind of traditional Chinese music instruments) performance, and also made it full of music representability. He had accomplished important achievements in erhu and pipa composition, music teaching and performance, as well as music instrument improving, by which he made a great number of contributions to national instrumental music. Liu' s ideology and pertained practice of improving Chinese traditional music has imparted a far-reaching multi-influences upon modern time and thereafter Chinese instrumental music.%刘天华是近代中国器乐建树卓著的国乐大师,他的一生为改革国乐而奋斗不息,开拓了二胡演奏音乐之新天地,并使之成为极富表现力的音乐。还在二胡、琵琶音乐创作、教学、演奏以及乐器改革、传统音乐记录等方面,建立了重要的业绩,对民族器乐有着多方面的贡献。刘天华关于国乐改进的思想与实践,对近代及其后的中国器乐,有着多方面的深远的影响。

  13. Optimizing information in Next-Generation-Sequencing (NGS) reads for improving de novo genome assembly.

    Science.gov (United States)

    Liu, Tsunglin; Tsai, Cheng-Hung; Lee, Wen-Bin; Chiang, Jung-Hsien

    2013-01-01

    Next-Generation-Sequencing is advantageous because of its much higher data throughput and much lower cost compared with the traditional Sanger method. However, NGS reads are shorter than Sanger reads, making de novo genome assembly very challenging. Because genome assembly is essential for all downstream biological studies, great efforts have been made to enhance the completeness of genome assembly, which requires the presence of long reads or long distance information. To improve de novo genome assembly, we develop a computational program, ARF-PE, to increase the length of Illumina reads. ARF-PE takes as input Illumina paired-end (PE) reads and recovers the original DNA fragments from which two ends the paired reads are obtained. On the PE data of four bacteria, ARF-PE recovered >87% of the DNA fragments and achieved >98% of perfect DNA fragment recovery. Using Velvet, SOAPdenovo, Newbler, and CABOG, we evaluated the benefits of recovered DNA fragments to genome assembly. For all four bacteria, the recovered DNA fragments increased the assembly contiguity. For example, the N50 lengths of the P. brasiliensis contigs assembled by SOAPdenovo and Newbler increased from 80,524 bp to 166,573 bp and from 80,655 bp to 193,388 bp, respectively. ARF-PE also increased assembly accuracy in many cases. On the PE data of two fungi and a human chromosome, ARF-PE doubled and tripled the N50 length. However, the assembly accuracies dropped, but still remained >91%. In general, ARF-PE can increase both assembly contiguity and accuracy for bacterial genomes. For complex eukaryotic genomes, ARF-PE is promising because it raises assembly contiguity. But future error correction is needed for ARF-PE to also increase the assembly accuracy. ARF-PE is freely available at http://140.116.235.124/~tliu/arf-pe/.

  14. Improving Random Number Generators in the Monte Carlo simulations via twisting and combining

    Science.gov (United States)

    Deng, Lih-Yuan; Guo, Rui; Lin, Dennis K. J.; Bai, Fengshan

    2008-03-01

    Problems for various random number generators accompanying the Wolff algorithm [U. Wolff, Phys. Rev. Lett. 62 (1989) 361; U. Wolff, Phys. Lett. B 228 (1989) 379] are discussed, including the hidden errors first reported in [A.M. Ferrenberg, D.P. Landau, Y.J. Wong, Phys. Rev. Lett. 69 (1992) 3382]. A general (though simple) method of twisting and combining for improving the performance of these generators is proposed. Some recent generators motivated by such a twisting and combining method with extremely long period are discussed. The proposed method provides a novel and simple way to improve RNGs in its performance.

  15. Generating Keywords Improves Metacomprehension and Self-Regulation in Elementary and Middle School Children

    Science.gov (United States)

    de Bruin, Anique B. H.; Thiede, Keith W.; Camp, Gino; Redford, Joshua

    2011-01-01

    The ability to monitor understanding of texts, usually referred to as metacomprehension accuracy, is typically quite poor in adult learners; however, recently interventions have been developed to improve accuracy. In two experiments, we evaluated whether generating delayed keywords prior to judging comprehension improved metacomprehension accuracy…

  16. The Efficiency Improvement by Combining HHO Gas, Coal and Oil in Boiler for Electricity Generation

    Directory of Open Access Journals (Sweden)

    Chia-Nan Wang

    2017-02-01

    Full Text Available Electricity is an essential energy that can benefit our daily lives. There are many sources available for electricity generation, such as coal, natural gas and nuclear. Among these sources, coal has been widely used in thermal power plants that account for about 41% of the worldwide electricity supply. However, these thermal power plants are also found to be a big pollution source to our environment. There is a need to explore alternative electricity sources and improve the efficiency of electricity generation. This research focuses on improving the efficiency of electricity generation through the use of hydrogen and oxygen mixture (HHO gas. In this research, experiments have been conducted to investigate the combined effects of HHO gas with other fuels, including coal and oil. The results show that the combinations of HHO with coal and oil can improve the efficiency of electricity generation while reducing the pollution to our environment.

  17. Social support improves mental health among the victims relocated to temporary housing following the Great East Japan Earthquake and Tsunami.

    Science.gov (United States)

    Koyama, Shihoko; Aida, Jun; Kawachi, Ichiro; Kondo, Naoki; Subramanian, S V; Ito, Kanade; Kobashi, Gen; Masuno, Kanako; Kondo, Katsunori; Osaka, Ken

    2014-01-01

    The victims of the Great East Japan Earthquake and Tsunami have been forced to live in temporary housing, mainly by two different methods of resettlement: group allocation that preserved pre-existing local social ties and lottery allocation. We examined the effects of various factors, including the resettlement methods and social support, on mental health. From February to March 2012, we completed a cross-sectional survey of 281 refugees aged 40 years or older, who had lost their homes in the tsunami and were living in temporary housing in Iwanuma city. Psychological distress of the victims was assessed using the Kessler Psychological Distress Scale (K6) that consists of six self-reported items. Participants were also asked whether they had provided or received social support during this time. Participants were categorized as "providing social support" if they listened to someone else's concerns and complaints, or "receiving social support" if they have someone who listened to their concerns and complaints. After adjusting for age and sex, multiple log-binomial regression analysis showed that participants without social support had a higher risk of psychological distress. Group allocation victims were more likely to receive social support than those who underwent lottery allocation. However, the resettlement approach did not significantly correlate with distress. Other factors associated with a higher risk of psychological distress were a younger age (55 or younger), living with either 3 people or 6 or more people, and having a lower income. The present results suggest that social support promotes the mental health of disaster victims.

  18. Significant improvements in InGaN/GaN nano-photoelectrodes for hydrogen generation by structure and polarization optimization.

    Science.gov (United States)

    Tao, Tao; Zhi, Ting; Liu, Bin; Li, Mingxue; Zhuang, Zhe; Dai, Jiangping; Li, Yi; Jiang, Fulong; Luo, Wenjun; Xie, Zili; Chen, Dunjun; Chen, Peng; Li, Zhaosheng; Zou, Zhigang; Zhang, Rong; Zheng, Youdou

    2016-02-08

    The photoelectrodes based on III-nitride semiconductors with high energy conversion efficiency especially for those self-driven ones are greatly desirable for hydrogen generation. In this study, highly ordered InGaN/GaN multiple-quantum-well nanorod-based photoelectrodes have been fabricated by a soft UV-curing nano-imprint lithography and a top-down etching technique, which improve the incident photon conversion efficiency (IPCE) from 16% (planar structure) to 42% (@ wavelength = 400 nm). More significantly, the turn-on voltage is reduced low to -0.6 V, which indicates the possibility of achieving self-driven. Furthermore, SiO2/Si3N4 dielectric distributed Bragg reflectors are employed to further improve the IPCE up to 60%. And the photocurrent (@ 1.1 V) is enhanced from 0.37 mA/cm(2) (original planar structure) to 1.5 mA/cm(2). These improvements may accelerate the possible applications for hydrogen generation with high energy-efficiency.

  19. The use of process models to inform and improve statistical models of nitrate occurrence, Great Miami River Basin, southwestern Ohio

    Science.gov (United States)

    Walter, Donald A.; Starn, J. Jeffrey

    2013-01-01

    Statistical models of nitrate occurrence in the glacial aquifer system of the northern United States, developed by the U.S. Geological Survey, use observed relations between nitrate concentrations and sets of explanatory variables—representing well-construction, environmental, and source characteristics— to predict the probability that nitrate, as nitrogen, will exceed a threshold concentration. However, the models do not explicitly account for the processes that control the transport of nitrogen from surface sources to a pumped well and use area-weighted mean spatial variables computed from within a circular buffer around the well as a simplified source-area conceptualization. The use of models that explicitly represent physical-transport processes can inform and, potentially, improve these statistical models. Specifically, groundwater-flow models simulate advective transport—predominant in many surficial aquifers— and can contribute to the refinement of the statistical models by (1) providing for improved, physically based representations of a source area to a well, and (2) allowing for more detailed estimates of environmental variables. A source area to a well, known as a contributing recharge area, represents the area at the water table that contributes recharge to a pumped well; a well pumped at a volumetric rate equal to the amount of recharge through a circular buffer will result in a contributing recharge area that is the same size as the buffer but has a shape that is a function of the hydrologic setting. These volume-equivalent contributing recharge areas will approximate circular buffers in areas of relatively flat hydraulic gradients, such as near groundwater divides, but in areas with steep hydraulic gradients will be elongated in the upgradient direction and agree less with the corresponding circular buffers. The degree to which process-model-estimated contributing recharge areas, which simulate advective transport and therefore account for

  20. Great Lakes Energy Institute

    Energy Technology Data Exchange (ETDEWEB)

    Alexander, J. Iwan [Case Western Reserve Univ., Cleveland, OH (United States)

    2012-11-18

    The vision of the Great Lakes Energy Institute is to enable the transition to advanced, sustainable energy generation, storage, distribution and utilization through coordinated research, development, and education. The Institute will place emphasis on translating leading edge research into next generation energy technology. The Institute’s research thrusts focus on coordinated research in decentralized power generation devices (e.g. fuel cells, wind turbines, solar photovoltaic devices), management of electrical power transmission and distribution, energy storage, and energy efficiency.

  1. Great Expectations

    NARCIS (Netherlands)

    Dickens, Charles

    2005-01-01

    One of Dickens's most renowned and enjoyable novels, Great Expectations tells the story of Pip, an orphan boy who wishes to transcend his humble origins and finds himself unexpectedly given the opportunity to live a life of wealth and respectability. Over the course of the tale, in which Pip

  2. Great Concern

    Institute of Scientific and Technical Information of China (English)

    1996-01-01

    Women of China magazine was first published in 1956. When the "cultural revolution" started in 1966 the magazine was obliged to stop publication. In 1979, when the magazine resumed publication, Mme. Soong Ching Ling, late vice chairperson of the National People’s Congress, wrote her congratulations—"Congratulations and Great Expectation."

  3. Great Expectations

    NARCIS (Netherlands)

    Dickens, Charles

    2005-01-01

    One of Dickens's most renowned and enjoyable novels, Great Expectations tells the story of Pip, an orphan boy who wishes to transcend his humble origins and finds himself unexpectedly given the opportunity to live a life of wealth and respectability. Over the course of the tale, in which Pip encount

  4. Great Comets

    Science.gov (United States)

    Burnham, Robert

    2000-05-01

    Spectacular and mysterious objects that come and go in the night sky, comets have dwelt in our popular culture for untold ages. As remnants from the formation of the Solar system, they are objects of key scientific research and space missions. As one of nature's most potent and dramatic dangers, they pose a threat to our safety--and yet they were the origin of our oceans and perhaps even life itself. This beautifully illustrated book tells the story of the biggest and most awe-inspiring of all comets: those that have earned the title "Great." Robert Burnham focuses on the Great comets Hyakutake in 1996 and Hale-Bopp in 1997, which gripped attention worldwide because, for many, they were the first comets ever seen. He places these two recent comets in the context of their predecessors from past ages, among them the famous Comet Halley. Great Comets explains the exciting new discoveries that have come from these magnificent objects and profiles the spaceprobes to comets due for launch in the next few years. The book even takes a peek behind Hollywood's science-fiction fantasies to assess the real risks humanity faces from potential impacts of both comets and asteroids. For everyone interested in astronomy, this exciting book reveals the secrets of the Great Comets and provides essential tools for keeping up to date with comet discoveries in the future. Robert Burnham has been an amateur astronomer since the mid-1950s. He has been a senior editor of Astronomy magazine (1986-88) and is the author of many books and CD-ROMS, including Comet Hale-Bopp: Find and Enjoy the Great Comet and Comet Explorer.

  5. A novel BN–MAS system composite ceramics with greatly improved mechanical properties prepared by low temperature hot-pressing

    Energy Technology Data Exchange (ETDEWEB)

    Cai, Delong; Yang, Zhihua, E-mail: zhyang@hit.edu.cn; Duan, Xiaoming; Liang, Bin; Li, Qian; Jia, Dechang, E-mail: dcjia@hit.edu.cn; Zhou, Yu

    2015-05-01

    A novel composite ceramics with excellent mechanical properties was fabricated by means of low temperature hot-pressing using hexagonal boron nitride (h-BN) and magnesium aluminum silicate (MAS) as raw materials. The influences of starting MAS content on the microstructural evolution and mechanical properties of the composites were investigated. The results indicate that the effective enhancement of relative density of composites has been achieved, which shows that MAS is an effective liquid-phase sintering aid during the hot-pressing. MAS also can improve the structural ordering of h-BN flakes. On the other hand, h-BN exhibits significant inhibiting effect on the crystallization of α-Cordierite. Furthermore, h-BN flakes with layered structure can play a role in strengthening the MAS matrix. So h-BN and MAS are considered to be co-enhanced by each other, resulting in better sintering ability and the mechanical properties of composite ceramics are better than that of both h-BN and MAS. Composite ceramics incorporated with 50 wt% MAS exhibits the highest bending strength and fracture toughness of 213±25 MPa and 2.49±0.35 MPa m{sup 1/2}, respectively.

  6. Organic geochemical characteristics of the Lower Cretaceous Abu Gabra Formation in the Great Moga oilfield, Muglad Basin, Sudan: Implications for depositional environment and oil-generation potential

    Science.gov (United States)

    Makeen, Yousif M.; Abdullah, Wan Hasiah; Hakimi, Mohammed Hail; Elhassan, Osman M. A.

    2015-03-01

    Organic-rich sediments within the Abu Gabra Formation from three wells in the Great Moga oilfield were analyzed using organic geochemistry and organic petrology. The analyzed samples generally contain more than 2.0 wt.% TOC and have a very good to excellent hydrocarbon generative potential. This is supported by high bitumen extract and hydrocarbon (HCs) yields with values exceeding 4000 and 2000 ppm, respectively. The Abu Gabra also have moderate to high hydrogen index (HI) values of 287-865 mg HC/g TOC and large amounts of amorphous organic matter and alginite, consistent with oil-prone Types I and Type II kerogen. Vitrinite reflectance (0.59-0.72) %Ro and pyrolysis Tmax (430-438 °C) indicate an early oil window stage. This is supported by bitumen/TOC ratios (0.04-0.09) and biomarker thermal maturity parameters with equilibrium C32 homohopane 22S/(22S + 22R) ratios (0.50-58), moretane/hopane (0.11-018) and C29ββ/(ββ + αα) (0.53-0.73) and 20S/(20S + 20R) ratios (0.26-0.48). The biomarkers are characterized by a dominance of low to medium molecular weight n-alkane compounds with significant waxy alkanes (n-C25-n-C34), moderately high Pr/Ph ratios (1.17-2.51), high abundance of C27 regular steranes, high C27/C29 regular sterane ratios, the presence of tricyclic terpanes and relatively low sterane/hopane ratios. These data indicate that the organic-rich sediments of the Abu Gabra Formation contain a mixture of aquatic (algal and bacterial) and terrigenous organic matter, deposited in a lacustrine environment and preserved under suboxic conditions.

  7. IMPROVING INITIAL GENERATIONS IN PSO ALGORITHM FOR TRANSPORTATION NETWORK DESIGN PROBLEM

    Directory of Open Access Journals (Sweden)

    Navid Afkar

    2015-02-01

    Full Text Available Transportation Network Design Problem (TNDP aims to select the best project sets among a number of new projects. Recently, metaheuristic methods are applied to solve TNDP in the sense of finding better solutions sooner. PSO as a metaheuristic method is based on stochastic optimization and is a parallel revolutionary computation technique. The PSO system initializes with a number of random solutions and seeks for optimal solution by improving generations. This paper studies the behavior of PSO on account of improving initial generation and fitness value domain to find better solutions in comparison with previous attempts.

  8. Optimization of Heat Exchangers with Dimpled Surfaces to Improve the Performance in Thermoelectric Generators Using a Kriging Model

    Science.gov (United States)

    Li, Shuai; Wang, Yiping; Wang, Tao; Yang, Xue; Deng, Yadong; Su, Chuqi

    2016-11-01

    Thermoelectric generators (TEGs) have become a topic of interest for vehicle exhaust energy recovery. Electrical power generation is deeply influenced by temperature differences, temperature uniformity and topological structures of TEGs. When the dimpled surfaces are adopted in heat exchangers, the heat transfer rates can be augmented with a minimal pressure drop. However, the temperature distribution shows a large gradient along the flow direction which has adverse effects on the power generation. In the current study, the heat exchanger performance was studied in a computational fluid dynamics (CFD) model. The dimple depth, dimple print diameter, and channel height were chosen as design variables. The objective function was defined as a combination of average temperature, temperature uniformity and pressure loss. The optimal Latin hypercube method was used to determine the experiment points as a method of design of the experiment in order to analyze the sensitivity of the design variables. A Kriging surrogate model was built and verified according to the database resulting from the CFD simulation. A multi-island genetic algorithm was used to optimize the structure in the heat exchanger based on the surrogate model. The results showed that the average temperature of the heat exchanger was most sensitive to the dimple depth. The pressure loss and temperature uniformity were most sensitive to the parameter of channel rear height, h 2. With an optimal design of channel structure, the temperature uniformity can be greatly improved compared with the initial exchanger, and the additional pressure loss also increased.

  9. Great Expectations for "Great Expectations."

    Science.gov (United States)

    Ridley, Cheryl

    Designed to make the study of Dickens'"Great Expectations" an appealing and worthwhile experience, this paper presents a unit of study intended to help students gain (1) an appreciation of Dickens' skill at creating realistic human characters; (2) an insight into the problems of a young man confused by false values and unreal ambitions and ways to…

  10. Using the self-filtering property of a femtosecond filament to improve second harmonic generation.

    Science.gov (United States)

    Shwa, David; Eisenmann, Shmuel; Marcus, Gilad; Zigler, Arie

    2009-04-13

    In this paper we demonstrate the use of NIR femtosecond filament for improving the generation of second harmonic using a type I BBO crystal. Using this method the beam propagation factor (M(2)) of the second harmonic was improved significantly; which led to enhancement of the attainable SH intensity by up to two orders of magnitude. This method can be beneficial for applications demanding high intensities, small spot size or long interaction lengths.

  11. The economic valuation on atmospheric improvement benefit by nuclear power generation

    Energy Technology Data Exchange (ETDEWEB)

    Kwak, S. J.; Yoo, S. H.; Han, S. Y.; Do, G. W.; Lee, J. S. [Korea Univ., Seoul (Korea)

    2000-12-01

    The major contents are as follows : To begin with, major air pollutants' emissions and emission reduction facilities in industrial sectors including a power generation were investigated and the future prospect was suggested. Environmental effects by attributes of air pollutions were summarized through a extensive literature survey. And the concept of benefit-cost based upon social costs and economic values of generation was established to estimate atmospheric improvement benefits by using a nuclear power. As a result of investigating many valuation methodologies that can estimate economic values of environmental improvement, we adopted MAUA(multi-attribute utility assessment) as a research method and estimated environmental costs by air pollutant and by power generating source. Also, we presented foreign case studies related to social costs in power generating sector and horizontally compared study's results home and abroad. Then, we set up four scenarios based on total generation that the 5th long-term power resources planning forecasted and calculated economic values of atmospheric improvement benefits among scenarios. Further, we suggested the results incorporating uncertainty of estimation parameters. Finally, we suggested a rational ground to move toward environment-friendly energy consumption and proposed a plan for the national energy policy against the green age in the 21th century. 147 refs., 45 figs., 103 tabs. (Author)

  12. An improved method for rapid generation and screening of Bacillus thuringiensis phage-resistant mutants.

    Science.gov (United States)

    Gillis, Annika; Mahillon, Jacques

    2014-11-01

    A simple method to isolate, screen and select phage-resistant mutants of Bacillus thuringiensis was developed. The traditional double-layer agar method was improved by a combination of the spotting assay using a lytic phage, to generate the bacterial-resistant mutants, with an inverted spotting assay (ISA), to rapidly screen the candidate-resistant mutants.

  13. Improving Low Voltage Ride Through Capability of Wind Generators Using Dynamic Voltage Restorer

    Science.gov (United States)

    Sivasankar, Gangatharan; Suresh Kumar, Velu

    2014-08-01

    The increasing wind power integration with power grid has forced the situation to improve the reliability of wind generators for stable operation. One important problem with induction generator based wind farm is its low ride through capability to the grid voltage disturbance. Any disturbance such as voltage dip may cause wind farm outages. Since wind power contribution is in predominant percentage, such outages may lead to stability problem. The proposed strategy is to use dynamic voltage controller (DVR) to compensate the voltage disturbance. The DVR provides the wind generator the ability to remain connected in grid and improve the reliability. The voltage dips due to symmetrical and unsymmetrical faults are considered for analysis. The vector control scheme is employed for fault compensation which uses software phase locked loop scheme and park dq0 transformation technique. Extensive simulation results are included to illustrate the control and operation of DVR.

  14. Great Lakes

    Science.gov (United States)

    Edsall, Thomas A.; Mac, Michael J.; Opler, Paul A.; Puckett Haecker, Catherine E.; Doran, Peter D.

    1998-01-01

    The Great Lakes region, as defined here, includes the Great Lakes and their drainage basins in Minnesota, Wisconsin, Illinois, Indiana, Ohio, Pennsylvania, and New York. The region also includes the portions of Minnesota, Wisconsin, and the 21 northernmost counties of Illinois that lie in the Mississippi River drainage basin, outside the floodplain of the river. The region spans about 9º of latitude and 20º of longitude and lies roughly halfway between the equator and the North Pole in a lowland corridor that extends from the Gulf of Mexico to the Arctic Ocean.The Great Lakes are the most prominent natural feature of the region (Fig. 1). They have a combined surface area of about 245,000 square kilometers and are among the largest, deepest lakes in the world. They are the largest single aggregation of fresh water on the planet (excluding the polar ice caps) and are the only glacial feature on Earth visible from the surface of the moon (The Nature Conservancy 1994a).The Great Lakes moderate the region’s climate, which presently ranges from subarctic in the north to humid continental warm in the south (Fig. 2), reflecting the movement of major weather masses from the north and south (U.S. Department of the Interior 1970; Eichenlaub 1979). The lakes act as heat sinks in summer and heat sources in winter and are major reservoirs that help humidify much of the region. They also create local precipitation belts in areas where air masses are pushed across the lakes by prevailing winds, pick up moisture from the lake surface, and then drop that moisture over land on the other side of the lake. The mean annual frost-free period—a general measure of the growing-season length for plants and some cold-blooded animals—varies from 60 days at higher elevations in the north to 160 days in lakeshore areas in the south. The climate influences the general distribution of wild plants and animals in the region and also influences the activities and distribution of the human

  15. Improvement of Axial Reflector Cross Section Generation Model for PWR Core Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Shim, Cheon Bo; Lee, Kyung Hoon; Cho, Jin Young [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2016-10-15

    This paper covers the study for improvement of axial reflector XS generation model. In the next section, the improved 1D core model is represented in detail. Reflector XS generated by the improved model is compared to that of the conventional model in the third section. Nuclear design parameters generated by these two XS sets are also covered in that section. Significant of this study is discussed in the last section. Two-step procedure has been regarded as the most practical approach for reactor core designs because it offers core design parameters quite rapidly within acceptable range. Thus this approach is adopted for SMART (System-integrated Modular Advanced Reac- Tor) core design in KAERI with the DeCART2D1.1/ MASTER4.0 (hereafter noted as DeCART2D/ MASTER) code system. Within the framework of the two-step procedure based SMART core design, various researches have been studied to improve the core design reliability and efficiency. One of them is improvement of reflector cross section (XS) generation models. While the conventional FA/reflector two-node model used for most core designs to generate reflector XS cannot consider the actual configuration of fuel rods that intersect at right angles to axial reflectors, the revised model reflects the axial fuel configuration by introducing the radially simplified core model. The significance of the model revision is evaluated by observing HGC generated by DeCART2D, reflector XS, and core design parameters generated by adopting the two models. And it is verified that about 30 ppm CBC error can be reduced and maximum Fq error decreases from about 6 % to 2.5 % by applying the revised model. Error of AO and axial power shapes are also reduced significantly. Therefore it can be concluded that the simplified 1D core model improves the accuracy of the axial reflector XS and leads to the two-step procedure reliability enhancement. Since it is hard for core designs to be free from the two-step approach, it is necessary to find

  16. Improved Optimization Study of Integration Strategies in Solar Aided Coal-Fired Power Generation System

    Directory of Open Access Journals (Sweden)

    Rongrong Zhai

    2015-01-01

    Full Text Available Solar aided coal-fired power generation system (SACFPGS combines solar energy and traditional coal-fired units in a particular way. This study mainly improves the solar thermal storage system. Genetic algorithm is used to optimize the SACFPGS. The best integration approach of the system, the collector area, and the corresponding thermal storage capacity to replace each high-pressure extraction are obtained when the amount of coal saving in unit solar investment per hour is at its largest. System performance before and after the improvement is compared. Results show that the improvement of the thermal storage system effectively increases the economic benefit of the integrated system.

  17. Power quality improvement of unbalanced power system with distributed generation units

    DEFF Research Database (Denmark)

    Hu, Y.; Chen, Zhe; Excell, P.

    2011-01-01

    This paper presents a power electronic system for improving the power quality of the unbalanced distributed generation units in three-phase four-wire system. In the system, small renewable power generation units, such as small PV generator, small wind turbines may be configured as single phase...... generation units. The random nature of renewable power sources may result in significant unbalance in the power network and affect the power quality. An electronic converter system is proposed to correct the system unbalance and harmonics so as to deal with the power quality problems. The operation...... and control of the converter are described. Simulation results have demonstrated that the system can effectively correct the unbalance and enhance the system power quality....

  18. Direct-Drive Synchronous Generators with Excitation from Strontium-Ferrite Magnets: Efficiency Improvement

    Science.gov (United States)

    Serebryakov, A.; Levin, N.; Sokolov, A.

    2012-01-01

    The authors consider the possibility to raise the specific power of synchronous generators with excitation from inexpensive permanent magnets. For this purpose, it is proposed to use tooth-wise windings and permanent magnets based on inexpensive magneto-hard material, e.g. strontium-ferrite. The magnets are to be placed between the rotor teeth, the alternate polarity of which is facing the air-gap. This provides a simpler and cheaper technology of making such a generator and improves its reliability. The proposed rational bevelling of the stator teeth not only raises the specific power of the generator but also reduces the level of noise and vibrations, extends the longevity of the magnets and bearings as well as facilitates the starting torque of the electric machine, e.g. if it is employed as wind generator.

  19. Improved Side Information Generation for Distributed Video Coding by Exploiting Spatial and Temporal Correlations

    Directory of Open Access Journals (Sweden)

    Ye Shuiming

    2009-01-01

    Full Text Available Distributed video coding (DVC is a video coding paradigm allowing low complexity encoding for emerging applications such as wireless video surveillance. Side information (SI generation is a key function in the DVC decoder, and plays a key-role in determining the performance of the codec. This paper proposes an improved SI generation for DVC, which exploits both spatial and temporal correlations in the sequences. Partially decoded Wyner-Ziv (WZ frames, based on initial SI by motion compensated temporal interpolation, are exploited to improve the performance of the whole SI generation. More specifically, an enhanced temporal frame interpolation is proposed, including motion vector refinement and smoothing, optimal compensation mode selection, and a new matching criterion for motion estimation. The improved SI technique is also applied to a new hybrid spatial and temporal error concealment scheme to conceal errors in WZ frames. Simulation results show that the proposed scheme can achieve up to 1.0 dB improvement in rate distortion performance in WZ frames for video with high motion, when compared to state-of-the-art DVC. In addition, both the objective and perceptual qualities of the corrupted sequences are significantly improved by the proposed hybrid error concealment scheme, outperforming both spatial and temporal concealments alone.

  20. Improvement of the efficiency of a space oxygen-hydrogen electrochemical generator

    Science.gov (United States)

    Glukhikh, I. N.; Shcherbakov, A. N.; Chelyaev, V. F.

    2014-12-01

    This paper describes the method used for cooling of an on-board oxygen-hydrogen electrochemical generator (ECG). Apart from electric power, such a unit produces water of reaction and heat; the latter is an additional load on the thermal control system of a space vehicle. This load is undesirable in long-duration space flights, when specific energy characteristics of on-board systems are the determining factors. It is suggested to partially compensate the energy consumption by the thermal control system of a space vehicle required for cooling of the electrochemical generator through evaporation of water of reaction from the generator into a vacuum (or through ice sublimation if the pressure in the ambient space is lower than that in the triple point of water.) Such method of cooling of an electrochemical generator improves specific energy parameters of an on-board electric power supply system, and, due to the presence of the negative feedback, it makes the operation of this system more stable. Estimates suggest that it is possible to compensate approximately one half of heat released from the generator through evaporation of its water of reaction at the electrical efficiency of the electrochemical generator equal to 60%. In this case, even minor increase in the efficiency of the generator would result in a considerable increase in the efficiency of the evaporative system intended for its cooling.

  1. Improved PCR-Based Detection of Soil Transmitted Helminth Infections Using a Next-Generation Sequencing Approach to Assay Design

    Science.gov (United States)

    Pilotte, Nils; Papaiakovou, Marina; Grant, Jessica R.; Bierwert, Lou Ann; Llewellyn, Stacey; McCarthy, James S.; Williams, Steven A.

    2016-01-01

    Background The soil transmitted helminths are a group of parasitic worms responsible for extensive morbidity in many of the world’s most economically depressed locations. With growing emphasis on disease mapping and eradication, the availability of accurate and cost-effective diagnostic measures is of paramount importance to global control and elimination efforts. While real-time PCR-based molecular detection assays have shown great promise, to date, these assays have utilized sub-optimal targets. By performing next-generation sequencing-based repeat analyses, we have identified high copy-number, non-coding DNA sequences from a series of soil transmitted pathogens. We have used these repetitive DNA elements as targets in the development of novel, multi-parallel, PCR-based diagnostic assays. Methodology/Principal Findings Utilizing next-generation sequencing and the Galaxy-based RepeatExplorer web server, we performed repeat DNA analysis on five species of soil transmitted helminths (Necator americanus, Ancylostoma duodenale, Trichuris trichiura, Ascaris lumbricoides, and Strongyloides stercoralis). Employing high copy-number, non-coding repeat DNA sequences as targets, novel real-time PCR assays were designed, and assays were tested against established molecular detection methods. Each assay provided consistent detection of genomic DNA at quantities of 2 fg or less, demonstrated species-specificity, and showed an improved limit of detection over the existing, proven PCR-based assay. Conclusions/Significance The utilization of next-generation sequencing-based repeat DNA analysis methodologies for the identification of molecular diagnostic targets has the ability to improve assay species-specificity and limits of detection. By exploiting such high copy-number repeat sequences, the assays described here will facilitate soil transmitted helminth diagnostic efforts. We recommend similar analyses when designing PCR-based diagnostic tests for the detection of other

  2. Research on the control strategy of distributed energy resources inverter based on improved virtual synchronous generator.

    Science.gov (United States)

    Gao, Changwei; Liu, Xiaoming; Chen, Hai

    2017-08-22

    This paper focus on the power fluctuations of the virtual synchronous generator(VSG) during the transition process. An improved virtual synchronous generator(IVSG) control strategy based on feed-forward compensation is proposed. Adjustable parameter of the compensation section can be modified to achieve the goal of reducing the order of the system. It can effectively suppress the power fluctuations of the VSG in transient process. To verify the effectiveness of the proposed control strategy for distributed energy resources inverter, the simulation model is set up in MATLAB/SIMULINK platform and physical experiment platform is established. Simulation and experiment results demonstrate the effectiveness of the proposed IVSG control strategy.

  3. 30-day mortality after coronary artery bypass grafting and valve surgery has greatly improved over the last decade, but the 1-year mortality remains constant

    DEFF Research Database (Denmark)

    Hansen, Laura Sommer; Hjortdal, Vibeke Elisabeth; Andreasen, Jan Jesper;

    2015-01-01

    the continued fall in short-term mortality reflects an actual improvement in late mortality, and subsequently, to investigate EuroSCORE as predictor of 1-year mortality. METHODS: A population-based cohort study of 25,602 patients from a 12-year period from three public university hospitals undergoing coronary...... (6.50% in 1999-2000 vs. 6.25% in 2011-2012 [P = 0.8086; Chi-square test]). DISCUSSION: The study demonstrates that both co-morbidity and age has a great impact on 30-day mortality. However, with time the impact of co-morbidity seems less. Thus, age is more important than co-morbidity in late...

  4. Possible Improvements to MCNP6 and its CEM/LAQGSM Event-Generators

    Energy Technology Data Exchange (ETDEWEB)

    Mashnik, Stepan Georgievich [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2015-08-04

    This report is intended to the MCNP6 developers and sponsors of MCNP6. It presents a set of suggested possible future improvements to MCNP6 and to its CEM03.03 and LAQGSM03.03 event-generators. A few suggested modifications of MCNP6 are quite simple, aimed at avoiding possible problems with running MCNP6 on various computers, i.e., these changes are not expected to change or improve any results, but should make the use of MCNP6 easier; such changes are expected to require limited man-power resources. On the other hand, several other suggested improvements require a serious further development of nuclear reaction models, are expected to improve significantly the predictive power of MCNP6 for a number of nuclear reactions; but, such developments require several years of work by real experts on nuclear reactions.

  5. Improving efficiency of supercontinuum generation in photonic crystal|fibers by direct degenerate four-wave-mixing

    DEFF Research Database (Denmark)

    Nikolov, Nikola Ivanov; Bang, Ole; Bjarklev, Anders Overgaard

    2002-01-01

    The efficiency of supercontinuum generation in photonic crystal fibers is significantly improved by designing the dispersion to allow widely separated spectral lines generated by degenerate four-wave-mixing directly from the pump to broaden and merge.......The efficiency of supercontinuum generation in photonic crystal fibers is significantly improved by designing the dispersion to allow widely separated spectral lines generated by degenerate four-wave-mixing directly from the pump to broaden and merge....

  6. Multipass configuration for improved squeezed vacuum generation in hot Rb vapor

    Science.gov (United States)

    Zhang, Mi; Guidry, Melissa A.; Lanning, R. Nicholas; Xiao, Zhihao; Dowling, Jonathan P.; Novikova, Irina; Mikhailov, Eugeniy E.

    2017-07-01

    We study a squeezed vacuum field generated in hot Rb vapor via the polarization self-rotation effect. Our previous experiments showed that the amount of observed squeezing may be limited by the contamination of the squeezed vacuum output with higher-order spatial modes, also generated inside the cell. Here, we demonstrate that the squeezing can be improved by making the light interact several times with a less dense atomic ensemble. With optimization of some parameters we can achieve up to -2.6 dB of squeezing in the multipass case, which is a 0.6 dB improvement compared to the single-pass experimental configuration. Our results show that, other than the optical depth of the medium, the spatial mode structure and the cell configuration also affect the squeezing level.

  7. An improved fuzzy synthetic condition assessment of a wind turbine generator system

    DEFF Research Database (Denmark)

    Li, H.; Hu, Y. G.; Yang, Chao;

    2013-01-01

    This paper presents an improved fuzzy synthetic model that is based on a real-time condition assessment method of a grid-connected wind turbine generator system (WTGS) to improve the operational reliability and optimize the maintenance strategy. First, a condition assessment framework is proposed...... by analyzing the monitored physical quantities of an actual WTGS with an electrically excited synchronous generator (EESG) and a full-scale converter. To examine the variable speed operational performances, the dynamic limits and the deterioration degree functions of the characteristic variables are determined...... 850 kW WTGS, real-time condition assessments are performed that utilize the proposed fuzzy synthetic method; the model’s effectiveness is also compared to a traditional fuzzy assessment method in which constant limited values and constant weights are adopted. The results show that the condition...

  8. Distributed generation system with PEM fuel cell for electrical power quality improvement

    Energy Technology Data Exchange (ETDEWEB)

    Ramirez, D.; Beites, L.F.; Blazquez, F. [Department of Electrical Engineering, ETSII, Escuela de Ingenieros Industriales, Universidad Politecnica de Madrid, C/ Jose Gutierrez Abascal 2, 28006 Madrid (Spain); Ballesteros, J.C. [Endesa Generacion, S.A. c/ Ribera de Loira 60, 28042 Madrid (Spain)

    2008-08-15

    In this paper, a physical model for a distributed generation (DG) system with power quality improvement capability is presented. The generating system consists of a 5 kW PEM fuel cell, a natural gas reformer, hydrogen storage bottles and a bank of ultra-capacitors. Additional power quality functions are implemented with a vector-controlled electronic converter for regulating the injected power. The capabilities of the system were experimentally tested on a scaled electrical network. It is composed of different lines, built with linear inductances and resistances, and taking into account both linear and non-linear loads. The ability to improve power quality was tested by means of different voltage and frequency perturbations produced on the physical model electrical network. (author)

  9. Geothermal electricity generation and desalination: an integrated process design to conserve latent heat with operational improvements

    KAUST Repository

    Missimer, Thomas M.

    2016-02-05

    A new process combination is proposed to link geothermal electricity generation with desalination. The concept involves maximizing the utilization of harvested latent heat by passing the turbine exhaust steam into a multiple effect distillation system and then into an adsorption desalination system. Processes are fully integrated to produce electricity, desalted water for consumer consumption, and make-up water for the geothermal extraction system. Further improvements in operational efficiency are achieved by adding a seawater reverse osmosis system to the site to utilize some of the generated electricity and using on-site aquifer storage and recovery to maximize water production with tailoring of seasonal capacity requirements and to meet facility maintenance requirements. The concept proposed conserves geothermally harvested latent heat and maximizes the economics of geothermal energy development. Development of a fully renewable energy electric generation-desalination-aquifer storage campus is introduced within the framework of geothermal energy development. © 2016 The Author(s). Published by Taylor & Francis

  10. Thermoelectric Figure of Merit of Low-temperature Generator Materials and Possibilities to Improve It

    Directory of Open Access Journals (Sweden)

    A.V. Simkin

    2014-01-01

    Full Text Available The thermoelectric properties of semiconductor material based on the bismuth telluride solid solution manufactured by the extrusion method, which has high mechanical properties, are studied in the work. Using the obtained values of thermoelectric semiconductor parameters, the coefficients of efficiency of generator thermopile of a flat design in the working temperature range are calculated. The ways to improve the efficiency of thermoelectric conversion through the use of bulk nanostructured thermoelectric materials based on bismuth telluride are considered.

  11. [Medical practice and clinical research: keys to generate knowledge and improve care].

    Science.gov (United States)

    Martínez Castuera-Gómez, Carla; Talavera, Juan O

    2013-01-01

    The increased quality in medical care may be immediately accomplished if clinical research is integrated into daily clinical practice. In the generation of medical knowledge are four steps: an unanswered question awakened from clinical practice, the critical analysis of specialized literature, the development of a research protocol, and, finally, the publication of outcomes. Decision making and continuous training are becoming part of an effective strategy of medical attention improvement.

  12. IMPROVING INITIAL GENERATIONS IN PSO ALGORITHM FOR TRANSPORTATION NETWORK DESIGN PROBLEM

    OpenAIRE

    2015-01-01

    Transportation Network Design Problem (TNDP) aims to select the best project sets among a number of new projects. Recently, metaheuristic methods are applied to solve TNDP in the sense of finding better solutions sooner. PSO as a metaheuristic method is based on stochastic optimization and is a parallel revolutionary computation technique. The PSO system initializes with a number of random solutions and seeks for optimal solution by improving generations. This paper studies the be...

  13. Thermoelectric generator placed on the human body: system modeling and energy conversion improvements

    Science.gov (United States)

    Lossec, M.; Multon, B.; Ben Ahmed, H.; Goupil, C.

    2010-10-01

    This paper focuses on the production of electricity using a thermoelectric generator placed on the human body connected to a dc-dc converter. The small difference in temperature between the hot heat source (e.g. the human body, Tb = 37 °C) and the cold heat source (e.g. ambient air, Ta = 22 °C), associated with a poor quality thermal coupling (mainly with the cold source), leads to a very low temperature gradient at the thermoelectric generator terminals and hence low productivity. Under these use conditions, the present article proposes an analysis of various ways to improve productivity given a surface capture system. Furthermore, we demonstrated, in this particular context, that maximizing the recovered electric power proves to be a different problem from that of maximizing efficiency, e.g. the figure of merit Z. We therefore define a new factor ZE, depending on the physical characteristics of thermoelectric materials, that maximizes electric power in the particular case where the thermal coupling is poor. Finally, this study highlights the benefit of sub-optimization of the power extracted from the thermoelectric generator to further improve efficiency of the overall system. We show that, given the conversion efficiency of the dc-dc converter, the maximum power point of the overall system is no more reached when the output voltage of the thermoelectric generator is equal to half of its electromotive force.

  14. Fuzzy Logic Controller Based Distributed Generation Integration Strategy for Stochastic Performance Improvement

    Directory of Open Access Journals (Sweden)

    Jagdish Prasad Sharma

    2016-01-01

    Full Text Available In the restructured environment, distributed generation (DG is considered as a very promising option due to a high initial capital cost of conventional plants, environmental concerns, and power shortage. Apart from the above, distributed generation (DG has also abilities to improve performance of feeder. Most of the distribution feeders have radial structure, which compel to observe the impact of distributed generations on feeder performance, having different characteristics and composition of time varying static ZIP load models. Two fuzzy-based expert system is proposed for selecting and ranking the most appropriated periods to an integration of distributed generations with a feeder. Madami type fuzzy logic controller was developed for sizing of distributed generation, whereas Sugeno type fuzzy logic controller was developed for the DG location. Input parameters for Madami fuzzy logic controller are substation reserve capacity, feeder power loss to load ratio, voltage unbalance, and apparent power imbalances. DG output, survivability index, and node distance from substation are chosen as input to Sugeno type fuzzy logic controller. The stochastic performance of proposed fuzzy expert systems was evaluated on a modified IEEE 37 node test feeder with 15 minutes characteristics time interval varying static ZIP load models.

  15. Performance of improved magnetostrictive vibrational power generator, simple and high power output for practical applications

    Energy Technology Data Exchange (ETDEWEB)

    Ueno, Toshiyuki, E-mail: ueno@ec.t.kanazawa-u.ac.jp [Kanazawa University, Kakuma-machi, Kanazawa-city, Ishikawa 920-1192 (Japan)

    2015-05-07

    Vibration based power generation technology is utilized effectively in various fields. Author has invented novel vibrational power generation device using magnetostrictive material. The device is based on parallel beam structure consisting of a rod of iron-gallium alloy wound with coil and yoke accompanied with permanent magnet. When bending force is applied on the tip of the device, the magnetization inside the rod varies with induced stress due to the inverse magnetostrictive effect. In vibration, the time variation of the magnetization generates voltage on the wound coil. The magnetostrictive type is advantageous over conventional such using piezoelectric or moving magnet types in high efficiency and high robustness, and low electrical impedance. Here, author has established device configuration, simple, rigid, and high power output endurable for practical applications. In addition, the improved device is lower cost using less volume of Fe-Ga and permanent magnet compared to our conventional, and its assembly by soldering is easy and fast suitable for mass production. Average power of 3 mW/cm{sup 3} under resonant vibration of 212 Hz and 1.2 G was obtained in miniature prototype using Fe-Ga rod of 2 × 0.5× 7 mm{sup 3}. Furthermore, the damping effect was observed, which demonstrates high energy conversion of the generator.

  16. Potential for Improving Potency and Specificity of Reovirus Oncolysis with Next-Generation Reovirus Variants

    Directory of Open Access Journals (Sweden)

    Adil Mohamed

    2015-12-01

    Full Text Available Viruses that specifically replicate in tumor over normal cells offer promising cancer therapies. Oncolytic viruses (OV not only kill the tumor cells directly; they also promote anti-tumor immunotherapeutic responses. Other major advantages of OVs are that they dose-escalate in tumors and can be genetically engineered to enhance potency and specificity. Unmodified wild type reovirus is a propitious OV currently in phase I–III clinical trials. This review summarizes modifications to reovirus that may improve potency and/or specificity during oncolysis. Classical genetics approaches have revealed reovirus variants with improved adaptation towards tumors or with enhanced ability to establish specific steps of virus replication and cell killing among transformed cells. The recent emergence of a reverse genetics system for reovirus has provided novel strategies to fine-tune reovirus proteins or introduce exogenous genes that could promote oncolytic activity. Over the next decade, these findings are likely to generate better-optimized second-generation reovirus vectors and improve the efficacy of oncolytic reotherapy.

  17. Second Generation Antipsychotics Improve Sexual Dysfunction in Schizophrenia: A Randomised Controlled Trial

    Directory of Open Access Journals (Sweden)

    Ahmed Mahmoud

    2011-01-01

    Full Text Available The impact of antipsychotic drug treatment on sexual function was investigated during a randomised trial comparing first generation antipsychotics (FGAs to (nonclozapine second generation antipsychotics (SGAs. Sexual function and quality of life were (rater-blind assessed in 42 patients with DSM-IV schizophrenia (aged 18–65 using the self-report version of the Derogatis Interview for Sexual Function (DISF-SR and the Heinrichs Quality of Life Scale (QLS, prior to, and 12 weeks following, a change in medication from an FGA drug to either an FGA or SGA drug. SGAs significantly improved sexual function compared to FGAs. Change in sexual function was associated with change in quality of life. Where impaired sexual functioning is a distressing adverse effect of treatment with an FGA agent, consideration should be given to switching to an SGA.

  18. Generation Expansion Planning in pool market: A hybrid modified game theory and improved genetic algorithm

    Energy Technology Data Exchange (ETDEWEB)

    Shayanfar, H.A.; Lahiji, A. Saliminia; Aghaei, J.; Rabiee, A. [Center of Excellence for Power System Automation and Operation, Electrical Engineering Department, Iran University of Science and Technology (IUST), Tehran (Iran)

    2009-05-15

    Unlike the traditional policy, Generation Expansion Planning (GEP) problem in competitive framework is complicated. In the new policy, each Generation Company (GENCO) decides to invest in such a way that obtains as much profit as possible. This paper presents a new hybrid algorithm to determine GEP in a Pool market. The proposed algorithm is divided in two programming levels: master and slave. In the master level a Modified Game Theory (MGT) is proposed to evaluate the contrast of GENCOs by the Independent System Operator (ISO). In the slave level, an Improved Genetic Algorithm (IGA) method is used to find the best solution of each GENCO for decision-making of investment. The validity of the proposed method is examined in the case study including three GENCOs with multi-type of power plants. The results show that the presented method is both satisfactory and consistent with expectation. (author)

  19. Improved pretreatment of lignocellulosic biomass using enzymatically-generated peracetic acid.

    Science.gov (United States)

    Yin, DeLu Tyler; Jing, Qing; AlDajani, Waleed Wafa; Duncan, Shona; Tschirner, Ulrike; Schilling, Jonathan; Kazlauskas, Romas J

    2011-04-01

    Release of sugars from lignocellulosic biomass is inefficient because lignin, an aromatic polymer, blocks access of enzymes to the sugar polymers. Pretreatments remove lignin and disrupt its structure, thereby enhancing sugar release. In previous work, enzymatically generated peracetic acid was used to pretreat aspen wood. This pretreatment removed 45% of the lignin and the subsequent saccharification released 97% of the sugars remaining after pretreatment. In this paper, the amount of enzyme needed is reduced tenfold using first, an improved enzyme variant that makes twice as much peracetic acid and second, a two-phase reaction to generate the peracetic acid, which allows enzyme reuse. In addition, the eight pretreatment cycles are reduced to only one by increasing the volume of peracetic acid solution and increasing the temperature to 60 °C and the reaction time to 6h. For the pretreatment step, the weight ratio of peracetic acid to wood determines the amount of lignin removed.

  20. Improved Metathesis Lifetime: Chelating Pyridinyl-Alcoholato Ligands in the Second Generation Grubbs Precatalyst

    Directory of Open Access Journals (Sweden)

    Jean I. du Toit

    2014-04-01

    Full Text Available Hemilabile ligands can release a free coordination site “on demand” of an incoming nucleophilic substrate while occupying it otherwise. This is believed to increase the thermal stability and activity of catalytic systems and therefore prevent decomposition via free coordination sites. In this investigation chelating pyridinyl-alcoholato ligands were identified as possible hemilabile ligands for incorporation into the second generation Grubbs precatalyst. The O,N-alcoholato ligands with different steric bulk could be successfully incorporated into the precatalysts. The incorporation of the sterically hindered, hemilabile O,N-ligands improved the thermal stability, activity, selectivity and lifetime of these complexes towards the metathesis of 1-octene. A decrease in the activity of the second generation Grubbs precatalyst was additionally observed after incorporating a hemilabile O,N-ligand with two phenyl groups into the system, while increasing their lifetime.

  1. An improved model for fragment-based lead generation at AstraZeneca.

    Science.gov (United States)

    Fuller, Nathan; Spadola, Loredana; Cowen, Scott; Patel, Joe; Schönherr, Heike; Cao, Qing; McKenzie, Andrew; Edfeldt, Fredrik; Rabow, Al; Goodnow, Robert

    2016-08-01

    Modest success rates in fragment-based lead generation (FBLG) projects at AstraZeneca (AZ) prompted operational changes to improve performance. In this review, we summarize these changes, emphasizing the construction and composition of the AZ fragment library, screening practices and working model. We describe the profiles of the screening method for specific fragment subsets and statistically assess our ability to follow up on fragment hits through near-neighbor selection. Performance analysis of our second-generation fragment library (FL2) in screening campaigns illustrates the complementary nature of flat and 3D fragments in exploring protein-binding pockets and highlights our ability to deliver fragment hits using multiple screening techniques for various target classes. The new model has had profound impact on the successful delivery of lead series to drug discovery projects.

  2. Improved photomask accuracy with a high-productivity DUV laser pattern generator

    Science.gov (United States)

    Öström, Thomas; Måhlén, Jonas; Karawajczyk, Andrzej; Rosling, Mats; Carlqvist, Per; Askebjer, Per; Karlin, Tord; Sallander, Jesper; Österberg, Anders

    2006-10-01

    A strategy for sub-100 nm technology nodes is to maximize the use of high-speed deep-UV laser pattern generators, reserving e-beam tools for the most critical photomask layers. With a 248 nm excimer laser and 0.82 NA projection optics, the Sigma7500 increases the application space of laser pattern generators. A programmable spatial light modulator (SLM) is imaged with partially coherent optics to compose the photomask pattern. Image profiles are enhanced with phase shifting in the pattern generator, and features below 200 nm are reliably printed. The Sigma7500 extends the SLM-based architecture with improvements to CD uniformity and placement accuracy, resulting from an error budget-based methodology. Among these improvements is a stiffer focus stage design with digital servos, resulting in improved focus stability. Tighter climate controls and improved dose control reduce drift during mask patterning. As a result, global composite CD uniformity below 5 nm (3σ) has been demonstrated, with placement accuracy below 10 nm (3σ) across the mask. Self-calibration methods are used to optimize and monitor system performance, reducing the need to print test plates. The SLM calibration camera views programmed test patterns, making it possible to evaluate image metrics such as CD uniformity and line edge roughness. The camera is also used to characterize image placement over the optical field. A feature called ProcessEqualizer TM has been developed to correct long-range CD errors arising from process effects on production photomasks. Mask data is sized in real time to compensate for pattern-dependent errors related to local pattern density, as well as for systematic pattern-independent errors such as radial CD signatures. Corrections are made in the pixel domain in the advanced adjustments processor, which also performs global biasing, stamp distortion compensation, and corner enhancement. In the Sigma7500, the mask pattern is imaged with full edge addressability in each

  3. Generations.

    Science.gov (United States)

    Chambers, David W

    2005-01-01

    Groups naturally promote their strengths and prefer values and rules that give them an identity and an advantage. This shows up as generational tensions across cohorts who share common experiences, including common elders. Dramatic cultural events in America since 1925 can help create an understanding of the differing value structures of the Silents, the Boomers, Gen Xers, and the Millennials. Differences in how these generations see motivation and values, fundamental reality, relations with others, and work are presented, as are some applications of these differences to the dental profession.

  4. Photovoltaic Plants Generation Improvement Using Li-Ion Batteries as Energy Buffer

    DEFF Research Database (Denmark)

    Beltran, H.; Swierczynski, Maciej Jozef; Luna, A.

    2011-01-01

    This paper analyzes the PV power plants operability improvement obtained when introducing energy storage (ES) systems which allow decoupling the power received from the sun on the photovoltaic (PV) panels from the power injected by the power plant into the grid. Two energy management strategies a...... are presented and analyzed, using Li-ion batteries as the energy storage buffer. The generated power redistribution and its variability reduction are All the results obtained in this paper are based on one year long simulations which used real irradiance data sampled every two minutes....

  5. Improved safety fast reactor with “reservoir” for delayed neutrons generating

    Science.gov (United States)

    Kulikov, G. G.; Apse, V. A.; Shmelev, A. N.; Kulikov, E. G.

    2017-01-01

    The paper considers the possibility to improve safety of fast reactors by using weak neutron absorber with large atomic weight as a material for external neutron reflector and for internal cavity in the reactor core (the neutron “reservoir”) where generation of some additional “delayed” neutron takes place. The effects produced by the external neutron reflector and the internal neutron “reservoir” on kinetic behavior of fast reactors are inter-compared. It is demonstrated that neutron kinetics of fast reactors with such external and internal zones becomes the quieter as compared with neutron kinetics of thermal reactors.

  6. Improved Multiobjective Harmony Search Algorithm with Application to Placement and Sizing of Distributed Generation

    Directory of Open Access Journals (Sweden)

    Wanxing Sheng

    2014-01-01

    Full Text Available To solve the comprehensive multiobjective optimization problem, this study proposes an improved metaheuristic searching algorithm with combination of harmony search and the fast nondominated sorting approach. This is a kind of the novel intelligent optimization algorithm for multiobjective harmony search (MOHS. The detailed description and the algorithm formulating are discussed. Taking the optimal placement and sizing issue of distributed generation (DG in distributed power system as one example, the solving procedure of the proposed method is given. Simulation result on modified IEEE 33-bus test system and comparison with NSGA-II algorithm has proved that the proposed MOHS can get promising results for engineering application.

  7. Z-Source-Inverter-Based Flexible Distributed Generation System Solution for Grid Power Quality Improvement

    DEFF Research Database (Denmark)

    Blaabjerg, Frede; Vilathgamuwa, D. M.; Loh, Poh Chiang

    2009-01-01

    Distributed generation (DG) systems are usually connected to the grid using power electronic converters. Power delivered from such DG sources depends on factors like energy availability and load demand. The converters used in power conversion do not operate with their full capacity all the time......-stage buck-boost inverter, recently proposed Z-source inverter (ZSI) is a good candidate for future DG systems. This paper presents a controller design for a ZSI-based DG system to improve power quality of distribution systems. The proposed control method is tested with simulation results obtained using...

  8. Great Taste, Less Waste: A cluster-randomized trial using a communications campaign to improve the quality of foods brought from home to school by elementary school children

    Science.gov (United States)

    Goldberg, Jeanne P.; Folta, Sara C.; Eliasziw, Misha; Koch-Weser, Susan; Economos, Christina D.; Hubbard, Kristie L.; Peterson, Lindsay A.; Wright, Catherine M.; Must, Aviva

    2015-01-01

    Objective Great Taste, Less Waste (GTLW), a communications campaign, capitalized on the synergy between healthy eating and eco-friendly behaviors to motivate children to bring more fruits and vegetables and fewer sugar-sweetened beverages (SSBs) to school. Methods A cluster-randomized trial in Eastern Massachusetts elementary schools in 2011–2012 tested the hypothesis that GTLW would improve the quality of foods from home more than a nutrition-only campaign – Foods 2 Choose (F2C) – or control. Lunch and snack items from home were measured at baseline and 7 months later using digital photography. Mixed linear models compared change in mean servings of fruits, vegetables, and SSBs among groups, and change in mean prevalence of packaging type. Change in prevalence of food items of interest was compared among groups using generalized linear models. Results 582 third and fourth graders from 82 classrooms in 12 schools participated. At follow-up, no significant differences were observed between groups in change in mean servings or change in prevalence of items of interest. No packaging differences were observed. Conclusion GTLW was well-received but no significant changes were observed in the quality of food brought to school. Whether classrooms are an effective environment for change remains to be explored. PMID:25735605

  9. Studies on an improved indigenous pressure wave generator and its testing with a pulse tube cooler

    Science.gov (United States)

    Jacob, S.; Karunanithi, R.; Narsimham, G. S. V. L.; Kranthi, J. Kumar; Damu, C.; Praveen, T.; Samir, M.; Mallappa, A.

    2014-01-01

    Earlier version of an indigenously developed Pressure Wave Generator (PWG) could not develop the necessary pressure ratio to satisfactorily operate a pulse tube cooler, largely due to high blow by losses in the piston cylinder seal gap and due to a few design deficiencies. Effect of different parameters like seal gap, piston diameter, piston stroke, moving mass and the piston back volume on the performance is studied analytically. Modifications were done to the PWG based on analysis and the performance is experimentally measured. A significant improvement in PWG performance is seen as a result of the modifications. The improved PWG is tested with the same pulse tube cooler but with different inertance tube configurations. A no load temperature of 130 K is achieved with an inertance tube configuration designed using Sage software. The delivered PV power is estimated to be 28.4 W which can produce a refrigeration of about 1 W at 80 K.

  10. The impact of increased interconnection on electricity systems with large penetrations of wind generation: A case study of Ireland and Great Britain

    DEFF Research Database (Denmark)

    Denny, E.; Tuohy, A.; Meibom, Peter

    2010-01-01

    Increased interconnection has been highlighted as potentially facilitating the integration of wind generation in power systems by increasing the flexibility to balance the variable wind output. This paper utilizes a stochastic unit commitment model to simulate the impacts of increased interconnec...

  11. Improved column-based radiochemical processing of the generator produced {sup 68}Ga

    Energy Technology Data Exchange (ETDEWEB)

    Loktionova, N.S. [Institute of Nuclear Chemistry, University of Mainz, 55128 Mainz (Germany); Belozub, A.N.; Filosofov, D.V. [Joint Institute of Nuclear Research, DLNP, 141980 Dubna (Russian Federation); Zhernosekov, K.P. [Chair of Radiochemistry, Technical University of Munich, 85748 Garching (Germany); Center for Radiopharmaceutical Science, Paul Scherrer Institute, 5232 Villigen, PSI (Switzerland); Laboratory of Radiochemistry and Environmental Chemistry, Paul Scherrer Institute, 5232 Villigen, PSI (Switzerland); Wagner, T. [Chair of Radiochemistry, Technical University of Munich, 85748 Garching (Germany); Tuerler, A. [Chair of Radiochemistry, Technical University of Munich, 85748 Garching (Germany); Laboratory of Radiochemistry and Environmental Chemistry, Paul Scherrer Institute, 5232 Villigen, PSI (Switzerland); Labor fuer Radio- und Umweltchemie Departement Chemie und Biochemie Universitaet Bern, 3012 Bern (Switzerland); Roesch, F., E-mail: frank.roesch@uni-mainz.d [Institute of Nuclear Chemistry, University of Mainz, 55128 Mainz (Germany)

    2011-07-15

    An improved chemical strategy for processing of the generator produced {sup 68}Ga was developed based on processing of the original {sup 68}Ge/{sup 68}Ga generator eluate on a micro-column. Direct pre-concentration and purification of the eluted {sup 68}Ga is performed on a cation-exchange resin in hydrochloric acid/acetone media. A supplementary step based on a second micro-column filled with a second resin allows direct re-adsorption of {sup 68}Ga eluted from the cation exchanger. {sup 68}Ga is finally striped from the second resin with a small volume of pure water. For this purpose a strong anion exchanger and a novel extraction chromatographic resin based on tetraalkyldiglycolamides are characterized. The strategy allows online pre-concentration and purification of {sup 68}Ga from the original generator eluate. The supplementary column allows transferring {sup 68}Ga with high radionuclide and chemical quality in the aqueous solution with small volume and low acidity useful for direct radiolabeling reactions.

  12. Accuracy Improvement of ASTER Stereo Satellite Generated DEM Using Texture Filter

    Institute of Scientific and Technical Information of China (English)

    Mandla V. Ravibabu; Kamal Jain; Surendra Pal Singh; Naga Jyothi Meeniga

    2010-01-01

    The grid DEM (digital elevation model) generation can be from any of a number of sources: for instance, analogue to digital conversion of contour maps followed by application of the TIN model, or direct elevation point modelling via digital photogrammetry applied to airborne images or satellite images. Currently, apart from the deployment of point-clouds from LiDAR data acquisition, the generally favoured approach refers to applications of digital photogrammetry. One of the most important steps in such deployment is the stereo matching process for conjugation point (pixel) establishment: very difficult in modelling any homogenous areas like water cover or forest canopied areas due to the lack of distinct spatial features. As a result, application of automated procedures is sure to generate erroneous elevation values. In this paper, we present and apply a method for improving the quality of stereo DEMs generated via utilization of an entropy texture filter. The filter was applied for extraction of homogenous areas before stereo matching so that a statistical texture filter could then be applied for removing anomalous evaluation values prior to interpolation and accuracy assessment via deployment of a spatial correlation technique. For exemplification, we used a stereo pair of ASTER 1B images.

  13. Community level workers: awareness generation for improving children’s health

    Directory of Open Access Journals (Sweden)

    Reetu Sharma

    2015-03-01

    Full Text Available Background: Routine immunisation and Vitamin A supplementation are two of many services offered by Government of India to reduce child mortality and morbidity. The three groups of community level workers (CLWs i.e. Auxiliary Nurse Midwives from health department, Anganwadi Workers from women and child development department and Accredited Social Health Activists (ASHAs are responsible for raising awareness and demand for these services. Objectives: The paper assesses the knowledge and participation of CLWs in generating awareness about the two services namely immunisation and Vitamin A supplementation among eligible mothers; and mother’s knowledge on these two services.  Methods: The study was conducted in 16 villages of two administrative blocks of Udaipur district in Rajasthan. Multistage purposive sampling was used for study area selection. Data collection was done using mixed methods-1 observations of 16 Maternal and Child Health and Nutrition days; 2 questionnaire based survey of 46 CLWs; and 3 questionnaire based survey of 321 programme beneficiaries i.e. infant’s mothers. Results: Limited knowledge of CLWs and their participation in awareness generation activities for the two services was noticed, which was also reflected in the poor knowledge among mothers on the two services. Conclusion: The study results may partially explain the poor child immunization in Rajasthan. Initiatives to increase CLWs’ knowledge of child immunization and Vitamin A supplementation; and increasing their participation in awareness generation activities need serious consideration by the healthcare system to improve immunization coverage.

  14. An improved Harmony Search algorithm for optimal scheduling of the diesel generators in oil rig platforms

    Energy Technology Data Exchange (ETDEWEB)

    Yadav, Parikshit; Kumar, Rajesh; Panda, S.K.; Chang, C.S. [Department of Electrical and Computer Engineering, National University of Singapore, Singapore 117576 (Singapore)

    2011-02-15

    Harmony Search (HS) algorithm is music based meta-heuristic optimization method which is analogous with the music improvisation process where musician continue to polish the pitches in order to obtain better harmony. The paper focuses on the optimal scheduling of the generators to reduce the fuel consumption in the oil rig platform. The accurate modeling of the specific fuel consumption is significant in this optimization. The specific fuel consumption has been modeled using cubic spline interpolation. The SFC curve is non-linear and discrete in nature, hence conventional methods fail to give optimal solution. HS algorithm has been used for optimal scheduling of the generators of both equal and unequal rating. Furthermore an Improved Harmony Search (IHS) method for generating new solution vectors that enhances accuracy and convergence rate of HS has been employed. The paper also focuses on the impacts of constant parameters on Harmony Search algorithm. Numerical results show that the IHS method has good convergence property. Moreover, the fuel consumption for IHS algorithm is lower when compared to HS and other heuristic or deterministic methods and is a powerful search algorithm for various engineering optimization problems. (author)

  15. Improvement of force factor of magnetostrictive vibration power generator for high efficiency

    Energy Technology Data Exchange (ETDEWEB)

    Kita, Shota, E-mail: happiest3.7@gmail.com; Ueno, Toshiyuki; Yamada, Sotoshi [Kanazawa University, Kakuma-machi, Kanazawa-city, Ishikawa 920-1164 (Japan)

    2015-05-07

    We develop high power magnetostrictive vibration power generator for battery-free wireless electronics. The generator is based on a cantilever of parallel beam structure consisting of coil-wound Galfenol and stainless plates with permanent magnet for bias. Oscillating force exerted on the tip bends the cantilever in vibration yields stress variation of Galfenol plate, which causes flux variation and generates voltage on coil due to the law of induction. This generator has advantages over conventional, such as piezoelectric or moving magnet types, in the point of high efficiency, highly robust, and low electrical impedance. Our concern is the improvement of energy conversion efficiency dependent on the dimension. Especially, force factor, the conversion ratio of the electromotive force (voltage) on the tip velocity in vibration, has an important role in energy conversion process. First, the theoretical value of the force factor is formulated and then the validity was verified by experiments, where we compare four types of prototype with parameters of the dimension using 7.0 × 1.5 × 50 mm beams of Galfenol with 1606-turn wound coil. In addition, the energy conversion efficiency of the prototypes depending on load resistance was measured. The most efficient prototype exhibits the maximum instantaneous power of 0.73 W and energy of 4.7 mJ at a free vibration of frequency of 202 Hz in the case of applied force is 25 N. Further, it was found that energy conversion efficiency depends not only on the force factor but also on the damping (mechanical loss) of the vibration.

  16. Encoding of High Frequencies Improves with Maturation of Action Potential Generation in Cultured Neocortical Neurons

    Science.gov (United States)

    Nikitin, Evgeny S.; Bal, Natalia V.; Malyshev, Aleksey; Ierusalimsky, Victor N.; Spivak, Yulia; Balaban, Pavel M.; Volgushev, Maxim

    2017-01-01

    The ability of neocortical neurons to detect and encode rapid changes at their inputs is crucial for basic neuronal computations, such as coincidence detection, precise synchronization of activity and spike-timing dependent plasticity. Indeed, populations of cortical neurons can respond to subtle changes of the input very fast, on a millisecond time scale. Theoretical studies and model simulations linked the encoding abilities of neuronal populations to the fast onset dynamics of action potentials (APs). Experimental results support this idea, however mechanisms of fast onset of APs in cortical neurons remain elusive. Studies in neuronal cultures, that are allowing for accurate control over conditions of growth and microenvironment during the development of neurons and provide better access to the spike initiation zone, may help to shed light on mechanisms of AP generation and encoding. Here we characterize properties of AP encoding in neocortical neurons grown for 11–25 days in culture. We show that encoding of high frequencies improves upon culture maturation, which is accompanied by the development of passive electrophysiological properties and AP generation. The onset of APs becomes faster with culture maturation. Statistical analysis using correlations and linear model approaches identified the onset dynamics of APs as a major predictor of age-dependent changes of encoding. Encoding of high frequencies strongly correlated also with the input resistance of neurons. Finally, we show that maturation of encoding properties of neurons in cultures is similar to the maturation of encoding in neurons studied in slices. These results show that maturation of AP generators and encoding is, to a large extent, determined genetically and takes place even without normal micro-environment and activity of the whole brain in vivo. This establishes neuronal cultures as a valid experimental model for studying mechanisms of AP generation and encoding, and their maturation. PMID

  17. Resolution Improvement and Pattern Generator Development for theMaskless Micro-Ion-Beam Reduction Lithography System

    Energy Technology Data Exchange (ETDEWEB)

    Jiang, Ximan [Univ. of California, Berkeley, CA (United States)

    2006-05-18

    The shrinking of IC devices has followed the Moore's Law for over three decades, which states that the density of transistors on integrated circuits will double about every two years. This great achievement is obtained via continuous advance in lithography technology. With the adoption of complicated resolution enhancement technologies, such as the phase shifting mask (PSM), the optical proximity correction (OPC), optical lithography with wavelength of 193 nm has enabled 45 nm printing by immersion method. However, this achievement comes together with the skyrocketing cost of masks, which makes the production of low volume application-specific IC (ASIC) impractical. In order to provide an economical lithography approach for low to medium volume advanced IC fabrication, a maskless ion beam lithography method, called Maskless Micro-ion-beam Reduction Lithography (MMRL), has been developed in the Lawrence Berkeley National Laboratory. The development of the prototype MMRL system has been described by Dr. Vinh Van Ngo in his Ph.D. thesis. But the resolution realized on the prototype MMRL system was far from the design expectation. In order to improve the resolution of the MMRL system, the ion optical system has been investigated. By integrating a field-free limiting aperture into the optical column, reducing the electromagnetic interference and cleaning the RF plasma, the resolution has been improved to around 50 nm. Computational analysis indicates that the MMRL system can be operated with an exposure field size of 0.25 mm and a beam half angle of 1.0 mrad on the wafer plane. Ion-ion interactions have been studied with a two-particle physics model. The results are in excellent agreement with those published by the other research groups. The charge-interaction analysis of MMRL shows that the ion-ion interactions must be reduced in order to obtain a throughput higher than 10 wafers per hour on 300-mm wafers. In addition, two different maskless lithography

  18. Improved Quantum Artificial Fish Algorithm Application to Distributed Network Considering Distributed Generation.

    Science.gov (United States)

    Du, Tingsong; Hu, Yang; Ke, Xianting

    2015-01-01

    An improved quantum artificial fish swarm algorithm (IQAFSA) for solving distributed network programming considering distributed generation is proposed in this work. The IQAFSA based on quantum computing which has exponential acceleration for heuristic algorithm uses quantum bits to code artificial fish and quantum revolving gate, preying behavior, and following behavior and variation of quantum artificial fish to update the artificial fish for searching for optimal value. Then, we apply the proposed new algorithm, the quantum artificial fish swarm algorithm (QAFSA), the basic artificial fish swarm algorithm (BAFSA), and the global edition artificial fish swarm algorithm (GAFSA) to the simulation experiments for some typical test functions, respectively. The simulation results demonstrate that the proposed algorithm can escape from the local extremum effectively and has higher convergence speed and better accuracy. Finally, applying IQAFSA to distributed network problems and the simulation results for 33-bus radial distribution network system show that IQAFSA can get the minimum power loss after comparing with BAFSA, GAFSA, and QAFSA.

  19. Towards a New Generation of Agricultural System Data, Models and Knowledge Products: Design and Improvement

    Science.gov (United States)

    Antle, John M.; Basso, Bruno; Conant, Richard T.; Godfray, H. Charles J.; Jones, James W.; Herrero, Mario; Howitt, Richard E.; Keating, Brian A.; Munoz-Carpena, Rafael; Rosenzweig, Cynthia

    2016-01-01

    This paper presents ideas for a new generation of agricultural system models that could meet the needs of a growing community of end-users exemplified by a set of Use Cases. We envision new data, models and knowledge products that could accelerate the innovation process that is needed to achieve the goal of achieving sustainable local, regional and global food security. We identify desirable features for models, and describe some of the potential advances that we envisage for model components and their integration. We propose an implementation strategy that would link a "pre-competitive" space for model development to a "competitive space" for knowledge product development and through private-public partnerships for new data infrastructure. Specific model improvements would be based on further testing and evaluation of existing models, the development and testing of modular model components and integration, and linkages of model integration platforms to new data management and visualization tools.

  20. Flux gain for a next-generation neutron reflectometer resulting from improved supermirror performance

    CERN Document Server

    Rehm, C

    2002-01-01

    Next-generation spallation neutron source facilities will offer instruments with unprecedented capabilities through simultaneous enhancement of source power and usage of advanced optical components. The Spallation Neutron Source (SNS), already under construction at Oak Ridge National Laboratory and scheduled to be completed by 2006, will provide greater than an order of magnitude more effective source flux than current state-of-the-art facilities, including the most advanced research reactors. An additional order of magnitude gain is expected through the use of new optical devices and instrumentation concepts. Many instrument designs require supermirror neutron guides with very high critical angles for total reflection. In this contribution, we will discuss how the performance of a modern neutron-scattering instrument depends on the efficiency of these supermirrors. We summarize current limitations of supermirror coatings and outline ideas for enhancing their performance, particularly for improving the reflec...

  1. Self-stacked submersible microbial fuel cell (SSMFC) for improved remote power generation from lake sediments

    DEFF Research Database (Denmark)

    Zhang, Yifeng; Angelidaki, Irini

    2012-01-01

    Electric energy can be harvested from aquatic sediments by utilizing microbialfuelcells (MFCs). A main challenge of this application is the limited voltage output. In this study, an innovative self-stackedsubmersible MFC (SSMFC) was developed to improve the voltage generation from lakesediments. ...... and at the same time store power. These results provide new insight into the development of effective MFC system, capable of extracting energy and promoting bioremediation of organic pollutants from sediments........ The SSMFC successfully produced a maximum power density of 294 mW/m2 and had an open circuit voltage (OCV) of 1.12 V. However, voltage reversal was observed in one cell at high current density. Investigation on the cause for voltage reversal revealed that voltage reversal was occurring only when low...

  2. Analysis of Entropy Generation for the Performance Improvement of a Tubular Solid Oxide Fuel Cell Stack

    Directory of Open Access Journals (Sweden)

    Vittorio Verda

    2009-03-01

    Full Text Available The aim of the paper is to investigate possible improvements in the design and operation of a tubular solid oxide fuel cell. To achieve this purpose, a CFD model of the cell is introduced. The model includes thermo-fluid dynamics, chemical reactions and electrochemistry. The fluid composition and mass flow rates at the inlet sections are obtained through a finite difference model of the whole stack. This model also provides boundary conditions for the radiation heat transfer. All of these conditions account for the position of each cell within the stack. The analysis of the cell performances is conducted on the basis of the entropy generation. The use of this technique makes it possible to identify the phenomena provoking the main irreversibilities, understand their causes and propose changes in the system design and operation.

  3. Dynamic response improvement of doubly fed induction generator-based wind farm using fuzzy logic controller

    Science.gov (United States)

    Hasanien, Hany M.; Al-Ammar, Essam A.

    2012-11-01

    Doubly fed induction generator (DFIG) based wind farm is today the most widely used concept. This paper presents dynamic response enhancement of DFIG based wind farm under remote fault conditions using the fuzzy logic controller. The goal of the work is to improve the dynamic response of DFIG based wind farm during and after the clearance of fault using the proposed controller. The stability of wind farm during and after the clearance of fault is investigated. The effectiveness of the fuzzy logic controller is then compared with that of a PI controller. The validity of the controllers in restoring the wind farms normal operation after the clearance of fault is illustrated by the simulation results which are carried out using MATLAB/SIMULINK. Simulation results are analyzed under different fault conditions.

  4. Improvements in the simulation of a main steam line break with steam generator tube rupture

    Science.gov (United States)

    Gallardo, Sergio; Querol, Andrea; Verdú, Gumersindo

    2014-06-01

    The result of simultaneous Main Steam Line Break (MSLB) and a Steam Generator Tube Rupture (SGTR) in a Pressurized Water Reactor (PWR) is a depressurization in the secondary and primary system because both systems are connected through the SGTR. The OECD/NEA ROSA-2 Test 5 performed in the Large Scale Test Facility (LSTF) reproduces these simultaneous breaks in a Pressurized Water Reactor (PWR). A simulation of this Test 5 was made with the thermal-hydraulic code TRACE5. Some discrepancies found, such as an underestimation of SG-A secondary pressure during the depressurization and overestimation of the primary pressure drop after the first Power Operated Relief Valve (PORV) opening can be improved increasing the nodalization of the Upper Head in the pressure vessel and meeting the actual fluid conditions of Upper Head during the transient.

  5. Towards a New Generation of Agricultural System Data, Models and Knowledge Products: Design and Improvement

    Science.gov (United States)

    Antle, John M.; Basso, Bruno; Conant, Richard T.; Godfray, H. Charles J.; Jones, James W.; Herrero, Mario; Howitt, Richard E.; Keating, Brian A.; Munoz-Carpena, Rafael; Rosenzweig, Cynthia

    2016-01-01

    This paper presents ideas for a new generation of agricultural system models that could meet the needs of a growing community of end-users exemplified by a set of Use Cases. We envision new data, models and knowledge products that could accelerate the innovation process that is needed to achieve the goal of achieving sustainable local, regional and global food security. We identify desirable features for models, and describe some of the potential advances that we envisage for model components and their integration. We propose an implementation strategy that would link a "pre-competitive" space for model development to a "competitive space" for knowledge product development and through private-public partnerships for new data infrastructure. Specific model improvements would be based on further testing and evaluation of existing models, the development and testing of modular model components and integration, and linkages of model integration platforms to new data management and visualization tools.

  6. Coordinated Control of PV Generation and EVs Charging Based on Improved DECell Algorithm

    Directory of Open Access Journals (Sweden)

    Guo Zhao

    2015-01-01

    Full Text Available Recently, the coordination of EVs’ charging and renewable energy has become a hot research all around the globe. Considering the requirements of EV owner and the influence of the PV output fluctuation on the power grid, a three-objective optimization model was established by controlling the EVs charging power during charging process. By integrating the meshing method into differential evolution cellular (DECell genetic algorithm, an improved differential evolution cellular (IDECell genetic algorithm was presented to solve the multiobjective optimization model. Compared to the NSGA-II and DECell, the IDECell algorithm showed better performance in the convergence and uniform distribution. Furthermore, the IDECell algorithm was applied to obtain the Pareto front of nondominated solutions. Followed by the normalized sorting of the nondominated solutions, the optimal solution was chosen to arrive at the optimized coordinated control strategy of PV generation and EVs charging. Compared to typical charging pattern, the optimized charging pattern could reduce the fluctuations of PV generation output power, satisfy the demand of EVs charging quantity, and save the total charging cost.

  7. Increasing National Energy Mix through Carbon Sequestration of Coal for Improved Power Generation

    Directory of Open Access Journals (Sweden)

    H. U. Ugwu

    2012-12-01

    Full Text Available In this paper, a novel technology of increasing national energy mix through carbon sequestration of coal has been advocated as a panacea for improving the nation’s power generation for electricity utilization and consumption. Consequently, electricity and petroleum products which have become the energy forms relied upon in most economic sectors of the world significantly exist with some changes in time vis-à-vis the energy consumption due to changes in the structure of the economy, energy prices, level of production of goods and services, technology and population, etc. Also, the exclusive dependence on income from oil for infrastructural development thus became the order of the day. These, are considered unsustainable especially with the total neglect of the agrarian nature of the country and the unproductive capabilities of other goods and services derivable from electricity generated. Hence, these seriously portend that urgent and drastic engineering strategies must be introduced in the energy sector to revamp the dwindling power generation. Thus, carbon sequestration of coal is the suggested option as a clean coal energy technology for power plant optimization. In this study, some air-dried Nigerian coals collected from different coal deposits across the country were utilized for the analyses to investigate their characteristics and rheology. The result obtained shows that chemically re-characterized Enugu sub-bituminous air dried coal has the highest carbon content ranging from 3.8% to 46.27% while its calorific value was found to be also high among others at the range of 22.3 to 28.4MJ/Kg, respectively. The result also shows that increase in carbon contents for all the coal samples resulted to increase in calorific value which would reduce the accumulation of greenhouse gases in the atmosphere if released by the burning of these fossil fuels. The technology of a good sequestered carbon if adopted will help in revamping the dwindling

  8. Methods to improve harvested energy and conversion efficiency of viscoelastic dielectric elastomer generators

    Science.gov (United States)

    Zhou, Jianyou; Jiang, Liying; Khayat, Roger E.

    2017-05-01

    As a new transduction technology, dielectric elastomer generators (DEGs) are capable of converting mechanical energy from diverse sources into electrical energy. However, their energy harvesting performance is strongly affected by the material viscoelasticity. Based on the finite-deformation viscoelasticity theory and the nonlinear coupled field theory for dielectric elastomers, this work presents a theoretical framework to model the performance of DEGs. Motivated by the recent experiments of DEGs with a triangular harvesting scheme, we propose a method to optimize the harvesting cycle, which could significantly improve the conversion efficiency of viscoelastic DEGs. From our simulation results, choosing a higher voltage power source appears to be an effective way to improve the performance of DEGs. In addition, optimizing the period of the discharging process of DEG can markedly increase its efficiency. Also, we have uncovered that the triangular harvesting scheme for DEGs, which is expected to harvest energy close to the maximum achievable energy, could be actually realized by choosing dielectric elastomers with a higher fraction of time-independent polymer networks. The theoretical framework and simulation results presented in this work are expected to benefit the optimal design of DEGs for different applications.

  9. Competing populations on fragmented landscapes with spatially structured heterogeneities: improved landscape generation and mixed dispersal strategies.

    Science.gov (United States)

    Hiebeler, David E

    2007-03-01

    Interactions between two species competing for space were studied using stochastic spatially explicit lattice-based simulations as well as pair approximations. The two species differed only in their dispersal strategies, which were characterized by the proportion of reproductive effort allocated to long-distance (far) dispersal versus short-distance (near) dispersal to adjacent sites. All population dynamics took place on landscapes with spatially clustered distributions of suitable habitat, described by two parameters specifying the amount and the local spatial autocorrelation of suitable habitat. Whereas previous results indicated that coexistence between pure near and far dispersers was very rare, taking place over only a very small region of the landscape parameter space, when mixed strategies are allowed, multiple strategies can coexist over a much wider variety of landscapes. On such spatially structured landscapes, the populations can partition the habitat according to local conditions, with one species using pure near dispersal to exploit large contiguous patches of suitable habitat, and another species using mixed dispersal to colonize isolated smaller patches (via far dispersal) and then rapidly exploit those patches (via near dispersal). An improved mean-field approximation which incorporates the spatially clustered habitat distribution is developed for modeling a single species on these landscapes, along with an improved Monte Carlo algorithm for generating spatially clustered habitat distributions.

  10. Operational availability improvement through online monitoring and advice for emergency diesel generator

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Jong Beom; Kim, Han Gon; Kim, Byong Sup [Korea Electric Power Research Institute, Taejon (Korea, Republic of); Golay, M.; Kang, C. W.; Sui, Y. [Massachusetts Institute of Technology, Massachusetts (United States)

    1998-12-31

    This research broadens the prime concern of nuclear power plant operations from safe performance to both economic and safe performance. First, emergency diesel generator is identified as one of main contributors for the lost plant availability through the review of plant forced outage records. The framework of an integrated architecture of performing modern on-line condition for operational availability improvement is configured in this work. For the development of the comprehensive sensor networks for complex target systems, and integrated methodology incorporating a structural hierarchy, a functional hierarchy, and a fault-symptom matrix is formulated. The second part of our research is development of intelligent diagnosis and maintenance advisory system, which employs Bayesian Belief Networks (BBNs) as a high level reasoning tool for incorporating inherent uncertainty for use in probabilistic inference. Our prototype diagnosis algorithms are represented explicitly through topological symbols and links between them in a causal direction. As new evidence from sensor network developed is entered into the model especially, our advisory system provides operational advice concerning both availability and safety, so that the operator is able to determine the likely failure modes, diagnose the system state, locate root causes, and take the most advantageous action. Thereby, this advice improves operational availability. 6 refs., 7 figs., 1 tab. (Author)

  11. Dielectric Elastomer Generator with Improved Energy Density and Conversion Efficiency Based on Polyurethane Composites.

    Science.gov (United States)

    Yin, Guoling; Yang, Yu; Song, Feilong; Renard, Christophe; Dang, Zhi-Min; Shi, Chang-Yong; Wang, Dongrui

    2017-02-15

    Dielectric elastomer generators (DEGs), which follow the physics of variable capacitors and harvest electric energy from mechanical work, have attracted intensive attention over the past decade. The lack of ideal dielectric elastomers, after nearly two decades of research, has become the bottleneck for DEGs' practical applications. Here, we fabricated a series of polyurethane-based ternary composites and estimated their potential as DEGs to harvest electric energy for the first time. Thermoplastic polyurethane (PU) with high relative permittivity (∼8) was chosen as the elastic matrix. Barium titanate (BT) nanoparticles and dibutyl phthalate (DBP) plasticizers, which were selected to improve the permittivity and mechanical properties, respectively, were blended into the PU matrix. As compared to pristine PU, the resultant ternary composite films fabricated through a solution casting approach showed enhanced permittivity, remarkably reduced elastic modulus, and relatively good electrical breakdown strength, dielectric loss, and strain at break. Most importantly, the harvested energy density of PU was significantly enhanced when blended with BT and DBP. A composite film containing 25 phr of BT and 60 phr of DBP with the harvested energy density of 1.71 mJ/cm(3) was achieved, which is about 4 times greater than that of pure PU and 8 times greater than that of VHB adhesives. Remarkably improved conversion efficiency of mechano-electric energy was also obtained via cofilling BT and DBP into PU. The results shown in this work strongly suggest compositing is a very promising way to provide better dielectric elastomer candidates for forthcoming practical DEGs.

  12. Coval: Improving Alignment Quality and Variant Calling Accuracy for Next-Generation Sequencing Data

    Science.gov (United States)

    Kosugi, Shunichi; Natsume, Satoshi; Yoshida, Kentaro; MacLean, Daniel; Cano, Liliana; Kamoun, Sophien; Terauchi, Ryohei

    2013-01-01

    Accurate identification of DNA polymorphisms using next-generation sequencing technology is challenging because of a high rate of sequencing error and incorrect mapping of reads to reference genomes. Currently available short read aligners and DNA variant callers suffer from these problems. We developed the Coval software to improve the quality of short read alignments. Coval is designed to minimize the incidence of spurious alignment of short reads, by filtering mismatched reads that remained in alignments after local realignment and error correction of mismatched reads. The error correction is executed based on the base quality and allele frequency at the non-reference positions for an individual or pooled sample. We demonstrated the utility of Coval by applying it to simulated genomes and experimentally obtained short-read data of rice, nematode, and mouse. Moreover, we found an unexpectedly large number of incorrectly mapped reads in ‘targeted’ alignments, where the whole genome sequencing reads had been aligned to a local genomic segment, and showed that Coval effectively eliminated such spurious alignments. We conclude that Coval significantly improves the quality of short-read sequence alignments, thereby increasing the calling accuracy of currently available tools for SNP and indel identification. Coval is available at http://sourceforge.net/projects/coval105/. PMID:24116042

  13. Coval: improving alignment quality and variant calling accuracy for next-generation sequencing data.

    Directory of Open Access Journals (Sweden)

    Shunichi Kosugi

    Full Text Available Accurate identification of DNA polymorphisms using next-generation sequencing technology is challenging because of a high rate of sequencing error and incorrect mapping of reads to reference genomes. Currently available short read aligners and DNA variant callers suffer from these problems. We developed the Coval software to improve the quality of short read alignments. Coval is designed to minimize the incidence of spurious alignment of short reads, by filtering mismatched reads that remained in alignments after local realignment and error correction of mismatched reads. The error correction is executed based on the base quality and allele frequency at the non-reference positions for an individual or pooled sample. We demonstrated the utility of Coval by applying it to simulated genomes and experimentally obtained short-read data of rice, nematode, and mouse. Moreover, we found an unexpectedly large number of incorrectly mapped reads in 'targeted' alignments, where the whole genome sequencing reads had been aligned to a local genomic segment, and showed that Coval effectively eliminated such spurious alignments. We conclude that Coval significantly improves the quality of short-read sequence alignments, thereby increasing the calling accuracy of currently available tools for SNP and indel identification. Coval is available at http://sourceforge.net/projects/coval105/.

  14. 30-day mortality after coronary artery bypass grafting and valve surgery has greatly improved over the last decade, but the 1-year mortality remains constant

    Directory of Open Access Journals (Sweden)

    Laura Sommer Hansen

    2015-01-01

    Full Text Available Introduction: European system for cardiac operative risk evaluation (EuroSCORE is a valuable tool in control of the quality of cardiac surgery. However, the validity of the risk score for the individual patient may be questioned. The present study was carried out to investigate whether the continued fall in short-term mortality reflects an actual improvement in late mortality, and subsequently, to investigate EuroSCORE as predictor of 1-year mortality. Methods: A population-based cohort study of 25,602 patients from a 12-year period from three public university hospitals undergoing coronary artery bypass grafting (CABG or valve surgery. Analysis was carried out based on EuroSCORE, age and co-morbidity factors (residual EuroSCORE. Results: During the period the average age increased from 65.1 ± 10.0 years to 68.9 ± 10.7 years (P < 0.001, one-way ANOVA, and the number of females increased from 26.0% to 28.2% (P = 0.0012, Chi-square test. The total EuroSCORE increased from 4.67 to 5.68 while the residual EuroSCORE decreased from 2.64 to 1.83. Thirty-day mortality decreased from 4.07% in 1999-2000 to 2.44% in 2011-2012 (P = 0.0056; Chi-square test, while 1-year mortality was unchanged (6.50% in 1999-2000 vs. 6.25% in 2011-2012 [P = 0.8086; Chi-square test]. Discussion: The study demonstrates that both co-morbidity and age has a great impact on 30-day mortality. However, with time the impact of co-morbidity seems less. Thus, age is more important than co-morbidity in late mortality. The various developments in short and long-term mortality are not readily explained. Conclusion: Although 30-day mortality of CABG and valve surgery patients has decreased during the 12-year period, the 1-year mortality remains the same.

  15. Origin of the improved photocatalytic activity of Cu incorporated TiO{sub 2} for hydrogen generation from water

    Energy Technology Data Exchange (ETDEWEB)

    Hu, Qianqian [Key Laboratory of Optoelectronic Materials Chemistry and Physics, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian 350002 (China); University of the Chinese Academy of Sciences, Beijing 100039 (China); Huang, Jiquan, E-mail: hjq@fjirsm.ac.cn [Key Laboratory of Optoelectronic Materials Chemistry and Physics, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian 350002 (China); Li, Guojing [Key Laboratory of Optoelectronic Materials Chemistry and Physics, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian 350002 (China); University of the Chinese Academy of Sciences, Beijing 100039 (China); Jiang, Yabin; Lan, Hai; Guo, Wang [Key Laboratory of Optoelectronic Materials Chemistry and Physics, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian 350002 (China); Cao, Yongge [Beijing Key Laboratory of Opto-electronic Functional Materials & Micro-nano Devices, Renmin University of China, Beijing 100872 (China)

    2016-09-30

    Highlights: • Cu incorporated TiO{sub 2} films were prepared under different atmosphere. • The optimal H{sub 2} generation rate is 2.80 μmol cm{sup −2} h{sup −1}, which is 56 times of pure TiO{sub 2}. • CuO is unstable and is reduced to Cu{sub 2}O or even to metallic Cu under irradiation. • Both Cu{sub 2}O and Cu are crucial factors for improving the photocatalytic activity. • Surface chemisorbed oxygen is another factor that influences the photoactivity. - Abstract: Cu incorporated TiO{sub 2} has been regarded as a low-cost photocatalyst with excellent photocatalytic performance for water splitting. Here we try to exploit the origin of its high reactivity by fabricating a series of Cu incorporated TiO{sub 2} films with the same Cu content under different atmosphere. Based on the comprehensive structure and surface characterizations, it is found that CuO is unstable and will be reduced to Cu{sub 2}O or even to metallic Cu under light irradiation during the photocatalytic reaction, and Cu{sub 2}O is an efficient co-catalyst that promotes the separation of photogenerated carriers while metallic Cu can further boost the photocatalytic activity. Besides, it is also noticed that the chemisorbed oxygen on the particle surface blocks the water splitting. By depositing TiO{sub 2} films under oxygen rich condition, oxygen vacancy is decreased greatly, which facilitates the removal of chemisorbed oxygen and the formation of metallic Cu during photocatalytic reaction, resulting in an ultra-high H{sub 2} evolution rate of 2.80 μmol cm{sup −2} h{sup −1}, which is about 55 times higher than that of pure TiO{sub 2}.

  16. Improvements of the Computerized Data Acquisition System for 25MWt Experimental Facility of Coal-fired MHD Generator

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    This paper introduces the design and development of a new computerized data acquisition system for the coal-fired magnetohydrodynamical (MHD) electrical power generation experiments. Compared to the previous system, it has a higher sampling rate and an improved simultaneity performance. It also improves the data collection method and sensor design for the measurement of Faraday voltages and Faraday currents. The system has been successfully used in many regular MHD generator tests. It provides an excellent base for the future research and development of the Coal-fired MHD electrical power generation.

  17. Improving fast generation of halo catalogues with higher order Lagrangian perturbation theory

    Science.gov (United States)

    Munari, Emiliano; Monaco, Pierluigi; Sefusatti, Emiliano; Castorina, Emanuele; Mohammad, Faizan G.; Anselmi, Stefano; Borgani, Stefano

    2017-03-01

    We present the latest version of PINOCCHIO, a code that generates catalogues of dark matter haloes in an approximate but fast way with respect to an N-body simulation. This code version implements a new on-the-fly production of halo catalogue on the past light cone with continuous time sampling, and the computation of particle and halo displacements are extended up to third-order Lagrangian perturbation theory (LPT), in contrast with previous versions that used Zel'dovich approximation. We run PINOCCHIO on the same initial configuration of a reference N-body simulation, so that the comparison extends to the object-by-object level. We consider haloes at redshifts 0 and 1, using different LPT orders either for halo construction or to compute halo final positions. We compare the clustering properties of PINOCCHIO haloes with those from the simulation by computing the power spectrum and two-point correlation function in real and redshift space (monopole and quadrupole), the bispectrum and the phase difference of halo distributions. We find that 2LPT and 3LPT give noticeable improvement. 3LPT provides the best agreement with N-body when it is used to displace haloes, while 2LPT gives better results for constructing haloes. At the highest orders, linear bias is typically recovered at a few per cent level. In Fourier space and using 3LPT for halo displacements, the halo power spectrum is recovered to within 10 per cent up to kmax ∼ 0.5 h Mpc-1. The results presented in this paper have interesting implications for the generation of large ensemble of mock surveys for the scientific exploitation of data from big surveys.

  18. The Great Recession was not so Great

    NARCIS (Netherlands)

    van Ours, J.C.

    2015-01-01

    The Great Recession is characterized by a GDP-decline that was unprecedented in the past decades. This paper discusses the implications of the Great Recession analyzing labor market data from 20 OECD countries. Comparing the Great Recession with the 1980s recession it is concluded that there is a hi

  19. Improved Quantum Artificial Fish Algorithm Application to Distributed Network Considering Distributed Generation

    Directory of Open Access Journals (Sweden)

    Tingsong Du

    2015-01-01

    Full Text Available An improved quantum artificial fish swarm algorithm (IQAFSA for solving distributed network programming considering distributed generation is proposed in this work. The IQAFSA based on quantum computing which has exponential acceleration for heuristic algorithm uses quantum bits to code artificial fish and quantum revolving gate, preying behavior, and following behavior and variation of quantum artificial fish to update the artificial fish for searching for optimal value. Then, we apply the proposed new algorithm, the quantum artificial fish swarm algorithm (QAFSA, the basic artificial fish swarm algorithm (BAFSA, and the global edition artificial fish swarm algorithm (GAFSA to the simulation experiments for some typical test functions, respectively. The simulation results demonstrate that the proposed algorithm can escape from the local extremum effectively and has higher convergence speed and better accuracy. Finally, applying IQAFSA to distributed network problems and the simulation results for 33-bus radial distribution network system show that IQAFSA can get the minimum power loss after comparing with BAFSA, GAFSA, and QAFSA.

  20. Extension of the CAPRAM mechanism with the improved mechanism generator GECKO-A

    Science.gov (United States)

    Herrmann, H.; Bräuer, P.; Mouchel-Vallon, C.; Tilgner, A.; Wolke, R.; Aumont, B.

    2013-12-01

    The ubiquitous abundance of organic compounds in natural and anthropogenically influenced eco-systems has put these compounds into the focus of environmental research. To investigate the chemistry of organic compounds in the tropospheric multiphase system, modelling can provide a useful tool. While in the gas phase several comprehensive near-explicit mechanisms exist, in the aqueous phase those mechanisms are very limited. The present study aims to advance the currently most comprehensive aqueous phase mechanism CAPRAM 3.0n (Tilgner and Herrmann, 2010; Bräuer et al., 2013) by means of automated mechanism self-construction. Therefore, the mechanism generator GECKO-A (Generator for Explicit Chemistry and Kinetics of Organics in the Atmosphere; see Aumont et al., 2005) has been advanced to the aqueous phase. A protocol has been designed for automated mechanism construction based on reviewed experimental data and evaluated prediction methods. The generator is able to describe the oxidation of aliphatic organic compounds by OH and NO3. For the mechanism construction, mainly structure-activity relationships are used. They are completed by Evans-Polanyi-type correlations, which have been further improved for the purpose of automated mechanism self-construction. GECKO-A has been used to create new CAPRAM versions, where branching ratios are introduced and new chemical subsystems with species with up to 4 carbon atoms are added. The currently most comprehensive version, CAPRAM 3.5alpha, includes about 2000 aqueous phase species and more than 3300 reactions in the aqueous phase. Process studies with the box model SPACCIM (SPectral Aerosol Cloud Chemistry Interaction Model; Wolke et al., 2005) have been performed using a meteorological scenario with non-permanent clouds. Besides the investigation of the concentration-time profiles, detailed time-resolved flux analyses have been performed. Several aqueous phase subsystems have been investigated, such as the formation of

  1. Source credibility and idea improvement have independent effects on unconscious plagiarism errors in recall and generate-new tasks.

    Science.gov (United States)

    Perfect, Timothy J; Field, Ian; Jones, Robert

    2009-01-01

    Unconscious plagiarism occurs when people try to generate new ideas or when they try to recall their own ideas from among a set generated by a group. In this study, the factors that independently influence these two forms of plagiarism error were examined. Participants initially generated solutions to real-world problems in 2 domains of knowledge in collaboration with a confederate presented as an expert in 1 domain. Subsequently, the participant generated improvements to half of the ideas from each person. Participants returned 1 day later to recall either their own ideas or their partner's ideas and to complete a generate-new task. A double dissociation was observed. Generate-new plagiarism was driven by partner expertise but not by idea improvement, whereas recall plagiarism was driven by improvement but not expertise. This improvement effect on recall plagiarism was seen for the recall-own but not the recall-partner task, suggesting that the increase in recall-own plagiarism is due to mistaken idea ownership, not source confusion.

  2. Great software debates

    CERN Document Server

    Davis, A

    2004-01-01

    The industry’s most outspoken and insightful critic explains how the software industry REALLY works. In Great Software Debates, Al Davis, shares what he has learned about the difference between the theory and the realities of business and encourages you to question and think about software engineering in ways that will help you succeed where others fail. In short, provocative essays, Davis fearlessly reveals the truth about process improvement, productivity, software quality, metrics, agile development, requirements documentation, modeling, software marketing and sales, empiricism, start-up financing, software research, requirements triage, software estimation, and entrepreneurship.

  3. GREAT Process Modeller user manual

    OpenAIRE

    Rueda, Urko; España, Sergio; Ruiz, Marcela

    2015-01-01

    This report contains instructions to install, uninstall and use GREAT Process Modeller, a tool that supports Communication Analysis, a communication-oriented business process modelling method. GREAT allows creating communicative event diagrams (i.e. business process models), specifying message structures (which describe the messages associated to each communicative event), and automatically generating a class diagram (representing the data model of an information system that would support suc...

  4. A solar PV augmented hybrid scheme for enhanced wind power generation through improved control strategy for grid connected doubly fed induction generator

    Directory of Open Access Journals (Sweden)

    Adikanda Parida

    2016-12-01

    Full Text Available In this paper, a wind power generation scheme using a grid connected doubly fed induction generator (DFIG augmented with solar PV has been proposed. A reactive power-based rotor speed and position estimation technique with reduced machine parameter sensitivity is also proposed to improve the performance of the DFIG controller. The estimation algorithm is based on model reference adaptive system (MRAS, which uses the air gap reactive power as the adjustable variable. The overall generation reliability of the wind energy conversion system can be considerably improved as both solar and wind energy can supplement each other during lean periods of either of the sources. The rotor-side DC-link voltage and active power generation at the stator terminals of the DFIG are maintained constant with minimum storage battery capacity using single converter arrangement without grid-side converter (GSC. The proposed scheme has been simulated and experimentally validated with a practical 2.5 kW DFIG using dSPACE CP1104 module which produced satisfactory results.

  5. A Design Alternative to Improve the Interconnection Capability of New Distributed-Generation Installations into Existing Griddle

    OpenAIRE

    2016-01-01

    Most distributed-generation facilities are performed on pre-built distribution grids. The design conditions of these existing grids may limit the ability of new users to get a connection due to technical and/or cost constraints. This work proposes a simple solution, adjusted to the relevant regulations and embodied in a radial distribution grid of Spanish low voltage, to improve the interconnection of distributed generation, usually grid connected photovoltaic systems. The proposed solution, ...

  6. Improved Detection by Next-Generation Sequencing of Pyrazinamide Resistance in Mycobacterium tuberculosis Isolates.

    Science.gov (United States)

    Maningi, Nontuthuko E; Daum, Luke T; Rodriguez, John D; Mphahlele, Matsie; Peters, Remco P H; Fischer, Gerald W; Chambers, James P; Fourie, P Bernard

    2015-12-01

    The technical limitations of common tests used for detecting pyrazinamide (PZA) resistance in Mycobacterium tuberculosis isolates pose challenges for comprehensive and accurate descriptions of drug resistance in patients with multidrug-resistant tuberculosis (MDR-TB). In this study, a 606-bp fragment (comprising the pncA coding region plus the promoter) was sequenced using Ion Torrent next-generation sequencing (NGS) to detect associated PZA resistance mutations in 88 recultured MDR-TB isolates from an archived series collected in 2001. These 88 isolates were previously Sanger sequenced, with 55 (61%) designated as carrying the wild-type pncA gene and 33 (37%) showing mutations. PZA susceptibility of the isolates was also determined using the Bactec 460 TB system and the Wayne test. In this study, isolates were recultured and susceptibility testing was performed in Bactec 960 MGIT. Concordance between NGS and MGIT results was 93% (n = 88), and concordance values between the Bactec 460, the Wayne test, or pncA gene Sanger sequencing and NGS results were 82% (n = 88), 83% (n = 88), and 89% (n = 88), respectively. NGS confirmed the majority of pncA mutations detected by Sanger sequencing but revealed several new and mixed-strain mutations that resolved discordancy in other phenotypic results. Importantly, in 53% (18/34) of these isolates, pncA mutations were located in the 151 to 360 region and warrant further exploration. In these isolates, with their known resistance to rifampin, NGS of pncA improved PZA resistance detection sensitivity to 97% and specificity to 94% using NGS as the gold standard and helped to resolve discordant results from conventional methodologies.

  7. GREAT: a web portal for Genome Regulatory Architecture Tools.

    Science.gov (United States)

    Bouyioukos, Costas; Bucchini, François; Elati, Mohamed; Képès, François

    2016-07-08

    GREAT (Genome REgulatory Architecture Tools) is a novel web portal for tools designed to generate user-friendly and biologically useful analysis of genome architecture and regulation. The online tools of GREAT are freely accessible and compatible with essentially any operating system which runs a modern browser. GREAT is based on the analysis of genome layout -defined as the respective positioning of co-functional genes- and its relation with chromosome architecture and gene expression. GREAT tools allow users to systematically detect regular patterns along co-functional genomic features in an automatic way consisting of three individual steps and respective interactive visualizations. In addition to the complete analysis of regularities, GREAT tools enable the use of periodicity and position information for improving the prediction of transcription factor binding sites using a multi-view machine learning approach. The outcome of this integrative approach features a multivariate analysis of the interplay between the location of a gene and its regulatory sequence. GREAT results are plotted in web interactive graphs and are available for download either as individual plots, self-contained interactive pages or as machine readable tables for downstream analysis. The GREAT portal can be reached at the following URL https://absynth.issb.genopole.fr/GREAT and each individual GREAT tool is available for downloading.

  8. Great Lakes Science Center

    Data.gov (United States)

    Federal Laboratory Consortium — Since 1927, Great Lakes Science Center (GLSC) research has provided critical information for the sound management of Great Lakes fish populations and other important...

  9. Improved cost of energy comparison of permanent magnet generators for large offshore wind turbines

    NARCIS (Netherlands)

    Hart, K.; McDonald, A.; Polinder, H.; Corr, E.; Carroll, J.

    2014-01-01

    This paper investigates geared and direct-drive permanent magnet generators for a typical offshore wind turbine, providing a detailed comparison of various wind turbine drivetrain configurations in order to minimise the Cost of Energy. The permanent magnet generator topologies considered include a d

  10. Improved cost of energy comparison of permanent magnet generators for large offshore wind turbines

    NARCIS (Netherlands)

    Hart, K.; McDonald, A.; Polinder, H.; Corr, E.; Carroll, J.

    2014-01-01

    This paper investigates geared and direct-drive permanent magnet generators for a typical offshore wind turbine, providing a detailed comparison of various wind turbine drivetrain configurations in order to minimise the Cost of Energy. The permanent magnet generator topologies considered include a

  11. User evaluation of a communication system that automatically generates captions to improve telephone communication

    NARCIS (Netherlands)

    Zekveld, A.A.; Kramer, S.E.; Kessens, J.M.; Vlaming, M.S.M.G.; Houtgast, T.

    2009-01-01

    This study examined the subjective benefit obtained from automatically generated captions during telephone-speech comprehension in the presence of babble noise. Short stories were presented by telephone either with or without captions that were generated offline by an automatic speech recognition

  12. Improvements on cool gas generators and their application in space propulsion systems

    NARCIS (Netherlands)

    Sanders, H.M.; Schuurbiers, C.A.H.; Vandeberg, R.J.

    2014-01-01

    Cool Gas Generators are an innovative means to store gas which can be used in propulsion and pressurization systems but also for inflatable structures and terrestrial applications. In Cool Gas Generators, the gas is stored chemically, without pressure or leakage and with a long life time without mai

  13. Physiological improvement in the copepod Eurytemora affinis through thermal and multi-generational selection

    DEFF Research Database (Denmark)

    Souissi, Anissa; Souissi, Sami; Hansen, Benni Winding

    2016-01-01

    . First two different copepod lines were obtained after long-term culture at constant cold (7°C) and warm (20°C) temperatures. Then both populations were transferred to a higher temperature of 24°C appropriate for aquaculture use and followed during five generations. During the first two generations (F1–F...

  14. Generation of subject-specific, dynamic, multisegment ankle and foot models to improve orthotic design: a feasibility study

    Directory of Open Access Journals (Sweden)

    Oosterwaal Michiel

    2011-11-01

    Full Text Available Abstract Background Currently, custom foot and ankle orthosis prescription and design tend to be based on traditional techniques, which can result in devices which vary greatly between clinicians and repeat prescription. The use of computational models of the foot may give further insight in the biomechanical effects of these devices and allow a more standardised approach to be taken to their design, however due to the complexity of the foot the models must be highly detailed and dynamic. Methods/Design Functional and anatomical datasets will be collected in a multicentre study from 10 healthy participants and 15 patients requiring orthotic devices. The patient group will include individuals with metarsalgia, flexible flat foot and drop foot. Each participant will undergo a clinical foot function assessment, 3D surface scans of the foot under different loading conditions, and detailed gait analysis including kinematic, kinetic, muscle activity and plantar pressure measurements in both barefoot and shod conditions. Following this each participant will undergo computed tomography (CT imaging of their foot and ankle under a range of loads and positions while plantar pressures are recorded. A further subgroup of participants will undergo magnetic resonance imaging (MRI of the foot and ankle. Imaging data will be segmented to derive the geometry of the bones and the orientation of the joint axes. Insertion points of muscles and ligaments will be determined from the MRI and CT-scans and soft tissue material properties computed from the loaded CT data in combination with the plantar pressure measurements. Gait analysis data will be used to drive the models and in combination with the 3D surface scans for scaling purposes. Predicted plantar pressures and muscle activation patterns predicted from the models will be compared to determine the validity of the models. Discussion This protocol will lead to the generation of unique datasets which will be used

  15. Optimal Placement and Sizing of Distributed Generation And Capacitor Bank For Loss Reduction And Reliability Improvement In Distribution Systems

    OpenAIRE

    Reza Baghipourr; Seyyed Mehdi Hosseini

    2014-01-01

    In this paper optimum size and location of the capacitors and distributed generators (DGs) are determined for reliability improvement and power loss reduction using genetic algorithm (GA). The main innovation of this paper is using both DG and Capacitor for the reliability improvement and power loss reduction. For this purpose an objective function consisting of reliability cost, power loss cost and also DG's and capacitor's investment cost are considered. The effectiveness of the proposed me...

  16. The determination of waste generation and composition as an essential tool to improve the waste management plan of a university.

    Science.gov (United States)

    Gallardo, A; Edo-Alcón, N; Carlos, M; Renau, M

    2016-07-01

    When many people work in organized institutions or enterprises, those institutions or enterprises become big meeting places that also have energy, water and resources necessities. One of these necessities is the correct management of the waste that is daily produced by these communities. Universities are a good example of institution where every day a great amount of people go to work or to study. But independently of their task, they use the different services at the University such as cafeterias, canteens, and photocopy and as a result of their activity a cleaning service is also needed. All these activities generate an environmental impact. Nowadays, many Universities have accepted the challenge to minimize this impact applying several measures. One of the impacts to be reduced is the waste generation. The first step to implement measures to implement a waste management plan at a University is to know the composition, the amount and the distribution of the waste generated in its facilities. As the waste composition and generation depend among other things on the climate, these variables should be analysed over one year. This research work estimates the waste generation and composition of a Spanish University, the Universitat Jaume I, during a school year. To achieve this challenge, all the waste streams generated at the University have been identified and quantified emphasizing on those which are not controlled. Furthermore, several statistical analyses have been carried out to know if the season of the year or the day of the week affect waste generation and composition. All this information will allow the University authorities to propose a set of minimization measures to enhance the current management.

  17. An improved PSO algorithm for generating protective SNP barcodes in breast cancer.

    Directory of Open Access Journals (Sweden)

    Li-Yeh Chuang

    Full Text Available BACKGROUND: Possible single nucleotide polymorphism (SNP interactions in breast cancer are usually not investigated in genome-wide association studies. Previously, we proposed a particle swarm optimization (PSO method to compute these kinds of SNP interactions. However, this PSO does not guarantee to find the best result in every implement, especially when high-dimensional data is investigated for SNP-SNP interactions. METHODOLOGY/PRINCIPAL FINDINGS: In this study, we propose IPSO algorithm to improve the reliability of PSO for the identification of the best protective SNP barcodes (SNP combinations and genotypes with maximum difference between cases and controls associated with breast cancer. SNP barcodes containing different numbers of SNPs were computed. The top five SNP barcode results are retained for computing the next SNP barcode with a one-SNP-increase for each processing step. Based on the simulated data for 23 SNPs of six steroid hormone metabolisms and signalling-related genes, the performance of our proposed IPSO algorithm is evaluated. Among 23 SNPs, 13 SNPs displayed significant odds ratio (OR values (1.268 to 0.848; p<0.05 for breast cancer. Based on IPSO algorithm, the jointed effect in terms of SNP barcodes with two to seven SNPs show significantly decreasing OR values (0.84 to 0.57; p<0.05 to 0.001. Using PSO algorithm, two to four SNPs show significantly decreasing OR values (0.84 to 0.77; p<0.05 to 0.001. Based on the results of 20 simulations, medians of the maximum differences for each SNP barcode generated by IPSO are higher than by PSO. The interquartile ranges of the boxplot, as well as the upper and lower hinges for each n-SNP barcode (n = 3∼10 are more narrow in IPSO than in PSO, suggesting that IPSO is highly reliable for SNP barcode identification. CONCLUSIONS/SIGNIFICANCE: Overall, the proposed IPSO algorithm is robust to provide exact identification of the best protective SNP barcodes for breast cancer.

  18. Power density improvement of the power conditioning circuit for combined piezoelectric and electrodynamic generators

    Science.gov (United States)

    Zessin, H.; Spies, P.; Mateu, L.

    2016-11-01

    In this study, we report a power management circuit for a combined piezoelectric- electrodynamic generator. A piezoelectric element is bonded to a spring steel cantilever beam and a magnet, used as tip mass, oscillates through a coil. This principle creates the combined generator. A test setup has been created to automate the characterization of the piezoelectric generator and its power management circuit. Three different power management circuits for the piezoelectric part of the combined generator have been analysed: a bridge rectifier, an SSHI circuit with an external inductance and an SSHI circuit which utilizes the coil of the electrodynamic generator as circuit element. The three circuits are compared in terms of their output power, efficiency and power density. The SSHI circuit with an external inductance has the highest output power and efficiency, followed by the SSHI circuit with the electrodynamic generator coil. The power density of the bridge rectifier is the highest but for higher efficiency the power density of the SSHI circuit with the coil of the electromagnetic generator reaches the best results.

  19. Real Time Monitoring and Test Vector Generation for Improved Flight Safety Project

    Data.gov (United States)

    National Aeronautics and Space Administration — As the complexity of flight controllers grows so does the cost associated with verification and validation (V&V). Current-generation controllers are reaching a...

  20. Improved weather generator algorithm for multisite simulation of precipitation and temperature

    CERN Document Server

    King, Leanna M; Simonovic, Slobodan P

    2016-01-01

    The KnnCAD Version 4 weather generator algorithm for nonparametric, multisite simulations of temperature and precipitation data is presented. The K-nearest neighbour weather generator essentially reshuffles the historical data, with replacement. In KnnCAD Version 4, a block resampling scheme is introduced to preserve the temporal correlation structure in temperature data. Perturbation of the reshuffled variable data is also added to enhance the generation of extreme values. A case study of the Upper Thames River Basin in Ontario, Canada is performed and the model is shown to simulate effectively the historical characteristics at the site. The KnnCAD Version 4 approach offers a major advantage over parametric and semi-parametric weather generators as it can be applied to multiple sites for simulation of temperatures and precipitation amounts without making assumptions regarding the spatial correlations and the probability distributions for each variable.

  1. Real Time Monitoring and Test Vector Generation for Improved Flight Safety Project

    Data.gov (United States)

    National Aeronautics and Space Administration — As the complexity of flight controllers grows so does the cost associated with verification and validation (V&V). Current-generation controllers are reaching...

  2. Use of thermoelectric generators for improve power dependability over grid power

    Energy Technology Data Exchange (ETDEWEB)

    Archer, Jack [Global Thermoelectric, Calgary (Canada)

    2005-07-01

    A natural gas transportation company was experiencing extensive pipeline corrosion on some sections of their pipeline protected by impressed current using grid power and rectifiers. After determining that grid power was being interrupted on the affected sections, the gas transporter began looking for a more dependable power supply and chose thermoelectric generators. Since installing thermoelectric generators in 2002, the pipeline potentials have stabilized and transporter was able to experience 100% operational time on affected sections. (author)

  3. Improvement of Voltage Quality of Micro Turbine Generator With Matrix Converter & Venturini Technique’s

    Directory of Open Access Journals (Sweden)

    C.Himabindu

    2014-07-01

    Full Text Available In recent years, application of Distributed Generation (DG sources has increased significantly. Micro turbine-Generator (MTG is well suitable for different distributed generation applications, because it can be connected in parallel to serve larger loads, can provide reliable power and has low-emission. The main characteristics of MTG can be summarized in low maintenance, capacity of operation with liquid and gas fuels (including natural gas and small area required for installation [1]. MTGs have the rated power from 30 to 250 kW, generating electricity in ac, and they can be installed in isolated conditions or synchronized with the electrical utility.MTGs are available as single-shaft or split-shaft units. Single-shaft unit is a high-speed synchronous machine with the compressor and turbine mounted on the same shaft. While, the split-shaft design uses a power turbine rotating at 3000 rpm and a conventional generator connected via a synchronous generator-PMSG, frequency converters (interface converters, and protection and control systems (Fig. 1[1] . The interface converter is used to convert PMSG output voltage frequency (high frequency to power system (50/60 Hz frequency.

  4. Critical Realism in Great Expectations

    Institute of Scientific and Technical Information of China (English)

    姚雪莲

    2014-01-01

    Great Expectations is an important work by English novelist Dickens.His novels not only reflect the life experience of a whole generation genuinely,but also disclose the social reality vividly in England in the middle 19th century.Its depth and width go beyond most of the works of his contemporaries.Great Expectations is the excellent novel of critical realism in the later period of Dickens.It describes the de-velopment of Pip’s grown-up and the disillusion of his“great expectations”.Educated by the reality,he came to realize what he pursued in the Vanity Fair was not valuable at all.So as to see clearer the great power of critical realism in Dickens’works and thus can understand the no-vel,this thesis analyzes the hero’s character development and the influential factors upon the formation of his character.

  5. Magnetocumulative generator

    Science.gov (United States)

    Pettibone, J.S.; Wheeler, P.C.

    1981-06-08

    An improved magnetocumulative generator is described that is useful for producing magnetic fields of very high energy content over large spatial volumes. The polar directed pleated magnetocumulative generator has a housing providing a housing chamber with an electrically conducting surface. The chamber forms a coaxial system having a small radius portion and a large radius portion. When a magnetic field is injected into the chamber, from an external source, most of the magnetic flux associated therewith positions itself in the small radius portion. The propagation of an explosive detonation through high-explosive layers disposed adjacent to the housing causes a phased closure of the chamber which sweeps most of the magnetic flux into the large radius portion of the coaxial system. The energy content of the magnetic field is greatly increased by flux stretching as well as by flux compression. The energy enhanced magnetic field is utilized within the housing chamber itself.

  6. Directed evolution methods for improving polypeptide folding and solubility and superfolder fluorescent proteins generated thereby

    Science.gov (United States)

    Waldo, Geoffrey S.

    2007-09-18

    The current invention provides methods of improving folding of polypeptides using a poorly folding domain as a component of a fusion protein comprising the poorly folding domain and a polypeptide of interest to be improved. The invention also provides novel green fluorescent proteins (GFPs) and red fluorescent proteins that have enhanced folding properties.

  7. HULK - Simple and fast generation of structured hexahedral meshes for improved subsurface simulations

    Science.gov (United States)

    Jansen, Gunnar; Sohrabi, Reza; Miller, Stephen A.

    2017-02-01

    Short for Hexahedra from Unique Location in (K)convex Polyhedra - HULK is a simple and efficient algorithm to generate hexahedral meshes from generic STL files describing a geological model to be used in simulation tools based on the finite element, finite volume or finite difference methods. Using binary space partitioning of the input geometry and octree refinement on the grid, a successive increase in accuracy of the mesh is achieved. We present the theoretical basis as well as the implementation procedure with three geological models with varying complexity, providing the basis on which the algorithm is evaluated. HULK generates high accuracy discretizations with cell counts suitable for state-of-the-art subsurface simulators and provides a new method for hexahedral mesh generation in geological settings.

  8. An improved optical tweezers assay for measuring the force generation of single kinesin molecules.

    Science.gov (United States)

    Nicholas, Matthew P; Rao, Lu; Gennerich, Arne

    2014-01-01

    Numerous microtubule-associated molecular motors, including several kinesins and cytoplasmic dynein, produce opposing forces that regulate spindle and chromosome positioning during mitosis. The motility and force generation of these motors are therefore critical to normal cell division, and dysfunction of these processes may contribute to human disease. Optical tweezers provide a powerful method for studying the nanometer motility and piconewton force generation of single motor proteins in vitro. Using kinesin-1 as a prototype, we present a set of step-by-step, optimized protocols for expressing a kinesin construct (K560-GFP) in Escherichia coli, purifying it, and studying its force generation in an optical tweezers microscope. We also provide detailed instructions on proper alignment and calibration of an optical trapping microscope. These methods provide a foundation for a variety of similar experiments.

  9. Improvements in ion reflux: An electrodialytic eluent generation and suppression device for ion chromatography.

    Science.gov (United States)

    Elkin, Kyle; Riviello, John; Small, Hamish

    2015-07-17

    This work describes a membrane based electrodialytic ion reflux device (IRD), which uses water as the pumped phase and integrates isocratic and gradient eluent generation and suppression. The current design incorporates several ion exchange membranes to create discrete chambers for suppression and eluent generation, while isolating the electrodes from the analytical stream. A small volume of recycled water can be used as the pumped phase while continuously refluxing the eluent ions. This current design permits electronically controlled eluent generation of at least 16.4μeq KOHmin(-1), while maintaining low suppressed background conductivity (<0.5μS/cm). The device was operated in gradient or isocratic mode continuously for up to 6 weeks. During this period, over 500 gradient and isocratic injections were performed, showing peak retention time precision below 1.5% RSD.

  10. Possibilities of improving the efficiency of power generation with regard to electrolytic water splitting

    Science.gov (United States)

    Knoche, K. F.; Hasberg, W.; Roth, M.

    The efficiency of power generation has a considerable influence on the upper limit of the total efficiency of electrolytic water splitting. This paper deals with the energetic potential of power generation processes and therefore with the water electrolysis processes. In the investigations reported here, it was assumed that the heat source is always the same (high-temperature nuclear reactor). For comparing thermochemical or hybrid water splitting cycles and water electrolysis, the upper limit of process temperatures must be comparable, too. Therefore, high-temperature processes for power generation have been investigated. A detailed energy and exergy balance is presented for the following cycles: (1) steam turbine cycles; (2) helium gas turbine cycles; (3) combined gas/steam turbine cycles. For these different processes an exergy analysis was performed in order to localize the process units, which make a considerable contribution to the decrease in total efficiency.

  11. A Rapid and Improved Method to Generate Recombinant Dengue Virus Vaccine Candidates.

    Science.gov (United States)

    Govindarajan, Dhanasekaran; Guan, Liming; Meschino, Steven; Fridman, Arthur; Bagchi, Ansu; Pak, Irene; ter Meulen, Jan; Casimiro, Danilo R; Bett, Andrew J

    2016-01-01

    Dengue is one of the most important mosquito-borne infections accounting for severe morbidity and mortality worldwide. Recently, the tetravalent chimeric live attenuated Dengue vaccine Dengvaxia® was approved for use in several dengue endemic countries. In general, live attenuated vaccines (LAV) are very efficacious and offer long-lasting immunity against virus-induced disease. Rationally designed LAVs can be generated through reverse genetics technology, a method of generating infectious recombinant viruses from full length cDNA contained in bacterial plasmids. In vitro transcribed (IVT) viral RNA from these infectious clones is transfected into susceptible cells to generate recombinant virus. However, the generation of full-length dengue virus cDNA clones can be difficult due to the genetic instability of viral sequences in bacterial plasmids. To circumvent the need for a single plasmid containing a full length cDNA, in vitro ligation of two or three cDNA fragments contained in separate plasmids can be used to generate a full-length dengue viral cDNA template. However, in vitro ligation of multiple fragments often yields low quality template for IVT reactions, resulting in inconsistent low yield RNA. These technical difficulties make recombinant virus recovery less efficient. In this study, we describe a simple, rapid and efficient method of using LONG-PCR to recover recombinant chimeric Yellow fever dengue (CYD) viruses as potential dengue vaccine candidates. Using this method, we were able to efficiently generate several viable recombinant viruses without introducing any artificial mutations into the viral genomes. We believe that the techniques reported here will enable rapid and efficient recovery of recombinant flaviviruses for evaluation as vaccine candidates and, be applicable to the recovery of other RNA viruses.

  12. Selecting the optimum method of heat transfer intensification to improve efficiency of thermoelectric generator

    Science.gov (United States)

    Leontyev, A. I.; Onishchenko, D. O.; Arutyunyan, G. A.

    2016-09-01

    The relevance of applying the methods of energy recovery from exhaust gases is substantiated. The principle of operation of a thermoelectric generator is described, the variant of its design is proposed, and the efficiency of various design methods of heat exchange intensification is compared. Designs are compared with a baseline configuration without heat transfer intensifiers in terms of coefficients of gas dynamic resistance ξ/ξ0 and the ratio of dimensionless criteria Nu/Nu0. The results of comparative analysis have proved the applicability of the methods of heat exchange intensification in the design of thermoelectric generators of various vehicles.

  13. Gain-switched CW fiber laser for improved supercontinuum generation in a PCF

    DEFF Research Database (Denmark)

    Larsen, Casper; Noordegraaf, Danny; Skovgaard, P.M.W.

    2011-01-01

    We demonstrate supercontinuum generation in a PCF pumped by a gain-switched high-power continuous wave (CW) fiber laser. The pulses generated by gain-switching have a peak power of more than 700 W, a duration around 200 ns, and a repetition rate of 200 kHz giving a high average power of almost 30 W......W/nm). This is considerably broader than when operating the same system under CW conditions. The presented approach is attractive due to the high power, power scalability, and reduced system complexity compared to picosecond-pumped supercontinuum sources. © 2011 Optical Society of America....

  14. A Design Alternative to Improve the Interconnection Capability of New Distributed-Generation Installations into Existing Griddle

    Directory of Open Access Journals (Sweden)

    José Agüero-Rubio

    2016-05-01

    Full Text Available Most distributed-generation facilities are performed on pre-built distribution grids. The design conditions of these existing grids may limit the ability of new users to get a connection due to technical and/or cost constraints. This work proposes a simple solution, adjusted to the relevant regulations and embodied in a radial distribution grid of Spanish low voltage, to improve the interconnection of distributed generation, usually grid connected photovoltaic systems. The proposed solution, based on increasing the section of the neutral line, achieves a capacity of increasing the length of the supply grid by more than 20%.

  15. Improvement of polypyrrole nanowire devices by plasmonic space charge generation: high photocurrent and wide spectral response by Ag nanoparticle decoration

    Science.gov (United States)

    Lee, Seung-Hoon; Lee, Seung Woo; Jang, Jaw-Won

    In this study, improvement of the opto-electronic properties of non-single crystallized nanowire devices with space charges generated by localized surface plasmon resonance (LSPR) is demonstrated. The photocurrent and spectral response of single polypyrrole (PPy) nanowire (NW) devices are increased by electrostatically attached Ag nanoparticles (Ag NPs). The photocurrent density is remarkably improved, up to 25.3 times, by the Ag NP decoration onto the PPy NW (PPyAgNPs NW) under blue light illumination. In addition, the PPyAgNPs NW shows a photocurrent decay time twice that of PPy NW, as well as an improved spectral response of the photocurrent. The improved photocurrent efficiency, decay time, and spectral response resulted from the space charges generated by the LSPR of Ag NPs. Furthermore, the increasing exponent (m) of the photocurrent (JPC ~Vm) and finite-differential time domain (FDTD) simulation straightforwardly indicate relatively large plasmonic space charge generation. Supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (no. 2013K1A3A1A32035429 and 2015R1A1A1A05027681).

  16. Data-Driven Hint Generation in Vast Solution Spaces: A Self-Improving Python Programming Tutor

    Science.gov (United States)

    Rivers, Kelly; Koedinger, Kenneth R.

    2017-01-01

    To provide personalized help to students who are working on code-writing problems, we introduce a data-driven tutoring system, ITAP (Intelligent Teaching Assistant for Programming). ITAP uses state abstraction, path construction, and state reification to automatically generate personalized hints for students, even when given states that have not…

  17. Principal-Generated YouTube Video as a Method of Improving Parental Involvement

    Science.gov (United States)

    Richards, Joey

    2013-01-01

    The purpose of this study was to evaluate the involvement level of parents and reveal whether principal-generated YouTube videos for regular communication would enhance levels of parental involvement at one North Texas Christian Middle School (pseudonym). The following questions guided this study: 1. What is the beginning level of parental…

  18. Improvement in thermal barriers to intense terahertz generation from photoconductive antennas

    Energy Technology Data Exchange (ETDEWEB)

    Ropagnol, X., E-mail: ropagnolx@gmail.com [INRS-EMT, Advanced Laser Light Source, Université du Québec, Varennes, Québec J3X 1S2 (Canada); Department of Physics, McGill University, Montreal Quebec, H3A OG4 (Canada); Bouvier, Marcel [Axis Photonique Inc., Varennes, Québec J3X 1S2 (Canada); Reid, M. [Department of Physics, University of Northern British Columbia, Prince George, British Colombia V2N 4Z9 (Canada); Ozaki, T. [INRS-EMT, Advanced Laser Light Source, Université du Québec, Varennes, Québec J3X 1S2 (Canada)

    2014-07-28

    We study the generation of free-space terahertz (THz) pulses at low THz frequencies using 6H-SiC and 4H-SiC photoconductive antennas. We investigate the dependence of the THz electric field radiated from the biased SiC emitters on the applied bias field and on the incident optical fluence. In this work, bias fields as high as 32 kV/cm, and optical fluences up to 2.5 mJ/cm{sup 2} (for the 400 nm laser), and 7.5 mJ/cm{sup 2} (for the 800 nm laser) were used. THz generation with back- and front-side illumination of the antennas is also examined. It is found that the SiC antenna, when illuminated from the backside, generates higher THz electric fields. The performance of 6H-SiC and ZnSe photoconductive antennas are compared. We show that, taking advantage of the superior thermal properties of SiC compare with ZnSe, the THz output power generated with the 6H-SiC photoconductive antenna under optimum conditions is 2.3 times larger that with a ZnSe photoconductive antenna.

  19. Data-Driven Hint Generation in Vast Solution Spaces: A Self-Improving Python Programming Tutor

    Science.gov (United States)

    Rivers, Kelly; Koedinger, Kenneth R.

    2017-01-01

    To provide personalized help to students who are working on code-writing problems, we introduce a data-driven tutoring system, ITAP (Intelligent Teaching Assistant for Programming). ITAP uses state abstraction, path construction, and state reification to automatically generate personalized hints for students, even when given states that have not…

  20. Europa's Great Lakes

    Science.gov (United States)

    Schmidt, B. E.; Blankenship, D. D.; Patterson, G. W.; Schenk, P. M.

    2012-04-01

    Unique to the surface of Europa, chaos terrain is diagnostic of the properties and dynamics of its icy shell. While models have suggested that partial melt within a thick shell or melt-through of a thin shell may form chaos, neither model has been able to definitively explain all observations of chaos terrain. However, we present a new model that suggests large melt lenses form within the shell and that water-ice interactions above and within these lenses drive the production of chaos. Our analysis of the geomorphology of Conamara Chaos and Thera Macula, was used to infer and test a four-stage lens-collapse chaos formation model: 1) Thermal plumes of warm, pure ice ascend through the shell melting the impure brittle ice above, producing a lake of briny water and surface down draw due to volume reduction. 2) Surface deflection and driving force from the plume below hydraulically seals the water in place. 3) Extension of the brittle ice lid generates fractures from below, allowing brines to enter and fluidize the ice matrix. 4) As the lens and now brash matrix refreeze, thermal expansion creates domes and raises the chaos feature above the background terrain. This new "lense-collapse" model indicates that chaos features form in the presence of a great deal of liquid water, and that large liquid water bodies exist within 3km of Europa's surface comparable in volume to the North American Great Lakes. The detection of shallow subsurface "lakes" implies that the ice shell is recycling rapidly and that Europa may be currently active. In this presentation, we will explore environments on Europa and their analogs on Earth, from collapsing Antarctic ice shelves to to subglacial volcanos in Iceland. I will present these new analyses, and describe how this new perspective informs the debate about Europa's habitability and future exploration.

  1. How sex- and age-disaggregated data and gender and generational analyses can improve humanitarian response.

    Science.gov (United States)

    Mazurana, Dyan; Benelli, Prisca; Walker, Peter

    2013-07-01

    Humanitarian aid remains largely driven by anecdote rather than by evidence. The contemporary humanitarian system has significant weaknesses with regard to data collection, analysis, and action at all stages of response to crises involving armed conflict or natural disaster. This paper argues that humanitarian actors can best determine and respond to vulnerabilities and needs if they use sex- and age-disaggregated data (SADD) and gender and generational analyses to help shape their assessments of crises-affected populations. Through case studies, the paper shows how gaps in information on sex and age limit the effectiveness of humanitarian response in all phases of a crisis. The case studies serve to show how proper collection, use, and analysis of SADD enable operational agencies to deliver assistance more effectively and efficiently. The evidence suggests that the employment of SADD and gender and generational analyses assists in saving lives and livelihoods in a crisis.

  2. Improvement of Dielectric Barrier Discharge Plasma Reactor for Ozone Generation by Electrode Shape

    Science.gov (United States)

    Shimizu, Masaki; Sato, Tohru; Kato, Shoji; Mukaigawa, Seiji; Takaki, Koichi; Fujiwara, Tamiya

    An effect of electrode shape on ozone generation in dielectric barrier discharge reactor is described in this article. Three different shape electrodes were employed as ground electrodes. A plane electrode is 6 cm in width, and 20 cm in length. A trench electrode has large number of knife-edge rails. A multipoint electrode has large number of four-sided pyramid projections on the plane. A high voltage plane electrode is covered with 0.5 mm thickness alumina layer worked as dielectric barrier. The experimental results show that the breakdown for the multipoint electrode occurs at 7.0 kVpp. This value is lower than 8.4 kVpp that is the breakdown voltage of the plane electrode. The ozone yield increases from 80 g/kWh to 130 g/kWh by changing the electrode shape from the plane to the multipoint. The ozone generation efficiency decreased with increase of the ozone concentration.

  3. Improving customer generation by increasing website performance and integrating IT systems

    OpenAIRE

    Ramlall, Shalini; Sanders, David; Powell, Henry; Ndzi, David

    2008-01-01

    This paper describes the research into the design of commercial websites. The research will lead to the identification of design elements that may have significant impact on user behaviour. The research will also investigate how these elements could be altered to provide a better browsing experience to users and ultimately increase online conversion and profit. The research focuses on the design of commercial websites. Their goal is to generate sales by selling products and services online or...

  4. Improved Detection by Next-Generation Sequencing of Pyrazinamide Resistance in Mycobacterium tuberculosis Isolates

    OpenAIRE

    Maningi, Nontuthuko E.; Daum, Luke T.; Rodriguez, John D.; Mphahlele, Matsie; Peters, Remco P. H.; Fischer, Gerald W.; Chambers, James P.; Fourie, P. Bernard

    2015-01-01

    The technical limitations of common tests used for detecting pyrazinamide (PZA) resistance in Mycobacterium tuberculosis isolates pose challenges for comprehensive and accurate descriptions of drug resistance in patients with multidrug-resistant tuberculosis (MDR-TB). In this study, a 606-bp fragment (comprising the pncA coding region plus the promoter) was sequenced using Ion Torrent next-generation sequencing (NGS) to detect associated PZA resistance mutations in 88 recultured MDR-TB isolat...

  5. Improvements on non-equilibrium and transport Green function techniques: The next-generation TRANSIESTA

    DEFF Research Database (Denmark)

    Papior, Nick Rübner; Lorente, Nicolás; Frederiksen, Thomas

    2017-01-01

    We present novel methods implemented within the non-equilibrium Green function code (NEGF) TRANSIESTA based on density functional theory (DFT). Our flexible, next-generation DFT–NEGF code handles devices with one or multiple electrodes (Ne≥1) with individual chemical potentials and electronic tem...... of a projected Hamiltonian, and fast inversion algorithms for large-scale simulations easily exceeding 106 atoms on workstation computers. The new features of both codes are demonstrated and bench-marked for relevant test systems....

  6. Hazardous Waste: EPA’s Generation and Management Data Need Further Improvement

    Science.gov (United States)

    1990-02-01

    System: Standards Applicable to Generators of Hazardous Waste and Standards Applicable to Owners and Operators of Hazardous Waste Treament , Storage...could be treated as liquids if they become more fluid when heated . More accurate quantitative meas- ures or continuous variables, such as the total...uses of incineration. For example, cement kilns and industrial boilers use hazardous waste as a fuel. The primary pur- pose is to produce heat for an

  7. Generation of Novel AAV Variants by Directed Evolution for Improved CFTR Delivery to Human Ciliated Airway Epithelium

    OpenAIRE

    Li, Wuping; Zhang, Liqun; Johnson, Jarrod S; Zhijian, Wu; Grieger, Joshua C; Ping-Jie, Xiao; Drouin, Lauren M; Agbandje-McKenna, Mavis; Pickles, Raymond J.; Samulski, R. Jude

    2009-01-01

    Recombinant adeno-associated virus (AAV) vectors expressing the cystic fibrosis transmembrane conductance regulator (CFTR) gene have been used to deliver CFTR to the airway epithelium of cystic fibrosis (CF) patients. However, no significant CFTR function has been demonstrated likely due to low transduction efficiencies of the AAV vectors. To improve AAV transduction efficiency for human airway epithelium (HAE), we generated a chimeric AAV library and performed directed evolution of AAV on an...

  8. AN IMPROVED BIT LOADING TECHNIQUE FOR ENHANCED ENERGY EFFICIENCY IN NEXT GENERATION VOICE/VIDEO APPLICATIONS

    Directory of Open Access Journals (Sweden)

    VINOTH BABU K.

    2016-04-01

    Full Text Available Multi input multi output (MIMO and orthogonal frequency division multiplexing (OFDM are the key techniques for the future wireless communication systems. Previous research in the above areas mainly concentrated on spectral efficiency improvement and very limited work has been done in terms of energy efficient transmission. In addition to spectral efficiency improvement, energy efficiency improvement has become an important research because of the slow progressing nature of the battery technology. Since most of the user equipments (UE rely on battery, the energy required to transmit the target bits should be minimized to avoid quick battery drain. The frequency selective fading nature of the wireless channel reduces the spectral and energy efficiency of OFDM based systems. Dynamic bit loading (DBL is one of the suitable solution to improve the spectral and energy efficiency of OFDM system in frequency selective fading environment. Simple dynamic bit loading (SDBL algorithm is identified to offer better energy efficiency with less system complexity. It is well suited for fixed data rate voice/video applications. When the number of target bits are very much larger than the available subcarriers, the conventional single input single output (SISO-SDBL scheme offers high bit error rate (BER and needs large transmit energy. To improve bit error performance we combine space frequency block codes (SFBC with SDBL, where the adaptations are done in both frequency and spatial domain. To improve the quality of service (QoS further, optimal transmit antenna selection (OTAS scheme is also combined with SFBC-SDBL scheme. The simulation results prove that the proposed schemes offer better QoS when compared to the conventional SISOSDBL scheme.

  9. Treatment of carbon fiber brush anodes for improving power generation in air–cathode microbial fuel cells

    KAUST Repository

    Feng, Yujie

    2010-04-02

    Carbon brush electrodes have been used to provide high surface areas for bacterial growth and high power densities in microbial fuel cells (MFCs). A high-temperature ammonia gas treatment has been used to enhance power generation, but less energy-intensive methods are needed for treating these electrodes in practice. Three different treatment methods are examined here for enhancing power generation of carbon fiber brushes: acid soaking (CF-A), heating (CF-H), and a combination of both processes (CF-AH). The combined heat and acid treatment improve power production to 1370 mW m-2, which is 34% larger than the untreated control (CF-C, 1020 mW m-2). This power density is 25% higher than using only acid treatment (1100 mW m-2) and 7% higher than that using only heat treatment (1280 mW m-2). XPS analysis of the treated and untreated anode materials indicates that power increases are related to higher N1s/C1s ratios and a lower C-O composition. These findings demonstrate efficient and simple methods for improving power generation using graphite fiber brushes, and provide insight into reasons for improving performance that may help to further increase power through other graphite fiber modifications. © 2009 Elsevier B.V. All rights reserved.

  10. Failure, the Next Generation: Why Rigorous Standards Are Not Sufficient to Improve Science Learning

    Science.gov (United States)

    Bair, Mary Antony; Bair, David Edward

    2014-01-01

    Although many states in the United States are adopting policies that require all students to complete college-preparatory science classes to graduate from high school, such policies have not always led to improved student outcomes. There is much speculation about the cause of the dismal results, but there is scant research on the processes by…

  11. A practical improvement, enhancing the large-scale synthesis of (+)-discodermolide: a third-generation approach.

    Science.gov (United States)

    Smith, Amos B; Freeze, B Scott; Brouard, Ignacio; Hirose, Tomoyasu

    2003-11-13

    [reaction: see text] A significant improvement to the Penn one-gram synthesis of (+)-discodermolide (1) has been achieved. Specifically, reduction of the steric bulk of the C(11) hydroxyl protecting group permits formation of the requisite AB Wittig salt at the expense of the undesired intramolecular cyclization upon treatment with PPh(3) at ambient pressure.

  12. Using Instructor-Generated Video Lectures in Online Mathematics Courses Improves Student Learning

    Science.gov (United States)

    Hegeman, Jennifer S.

    2015-01-01

    Low retention rates in online freshman-level mathematics courses are a concern, especially at postsecondary institutions that serve academically unprepared students. The purpose of this study was to determine if student performance in an online College Algebra course that relies heavily on text-based multimedia tools can be improved by replacing…

  13. Improving Learning through Interventions of Student-Generated Questions and Concept Maps

    Science.gov (United States)

    Berry, Jack W.; Chew, Stephen L.

    2008-01-01

    Using the principles of the scholarship of teaching and learning, we evaluated 2 learning strategies to determine if they could improve student exam performance in general psychology. After the second of 3 exams, we gave students the option of participating in a specific learning activity and assessed its impact using the third exam. In Study 1,…

  14. Improved quantification of collagen anisotropy with polarization-resolved second harmonic generation microscopy.

    Science.gov (United States)

    Hristu, Radu; Stanciu, Stefan G; Tranca, Denis E; Stanciu, George A

    2017-09-01

    Imaging tissue samples by polarization-resolved second harmonic generation microscopy provides both qualitative and quantitative insights into collagen organization in a label-free manner. Polarization-resolved second harmonic generation microscopy goes beyond simple intensity-based imaging by adding the laser beam polarization component and applying different quantitative metrics such as the anisotropy factor. It thus provides valuable information on collagen arrangement not available with intensity measurements alone. Current established approaches are limited to calculating the anisotropy factor for only a particular laser beam polarization and no general guidelines on how to select the best laser beam polarization have yet been defined. Here, we introduce a novel methodology for selecting the optimal laser beam polarization for characterizing tissues using the anisotropy in the purpose of identifying cancer signatures. We show that the anisotropy factor exhibits a similar laser beam polarization dependence to the second harmonic intensity and we combine it with the collagen orientation index computed by Fast Fourier Transform analysis of the recorded images to establish a framework for choosing the laser beam polarization that is optimal for an accurate interpretation of polarization-resolved second harmonic generation microscopy images and anisotropy maps, and hence a better differentiation between healthy and dysplastic areas. SHG image of skin tissue (a) and a selected area of interest for which we compute the SHG intensity (b) and anisotropy factor (c) dependence on the laser beam polarization and also the FFT spectrum (d) to evaluate the collagen orientation index. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  15. Interim Report: Air-Cooled Condensers for Next Generation Geothermal Power Plants Improved Binary Cycle Performance

    Energy Technology Data Exchange (ETDEWEB)

    Daniel S. Wendt; Greg L. Mines

    2010-09-01

    As geothermal resources that are more expensive to develop are utilized for power generation, there will be increased incentive to use more efficient power plants. This is expected to be the case with Enhanced Geothermal System (EGS) resources. These resources will likely require wells drilled to depths greater than encountered with hydrothermal resources, and will have the added costs for stimulation to create the subsurface reservoir. It is postulated that plants generating power from these resources will likely utilize the binary cycle technology where heat is rejected sensibly to the ambient. The consumptive use of a portion of the produced geothermal fluid for evaporative heat rejection in the conventional flash-steam conversion cycle is likely to preclude its use with EGS resources. This will be especially true in those areas where there is a high demand for finite supplies of water. Though they have no consumptive use of water, using air-cooling systems for heat rejection has disadvantages. These systems have higher capital costs, reduced power output (heat is rejected at the higher dry-bulb temperature), increased parasitics (fan power), and greater variability in power generation on both a diurnal and annual basis (larger variation in the dry-bulb temperature). This is an interim report for the task ‘Air-Cooled Condensers in Next- Generation Conversion Systems’. The work performed was specifically aimed at a plant that uses commercially available binary cycle technologies with an EGS resource. Concepts were evaluated that have the potential to increase performance, lower cost, or mitigate the adverse effects of off-design operation. The impact on both cost and performance were determined for the concepts considered, and the scenarios identified where a particular concept is best suited. Most, but not all, of the concepts evaluated are associated with the rejection of heat. This report specifically addresses three of the concepts evaluated: the use of

  16. Engineering Evaluation and Analysis for the Improvement of Military Standard Generators. Volume 2

    Science.gov (United States)

    1987-05-29

    THE ELECTRONIC CONTROL SYSTEM OF THE MEP-114A 30-kW DIESEL ENGINE DRIVEN GENERATOR SET SAugust 1985 Prepared by: Steven R. Landa Mission Research...Corporation 5434 Ruffin Road San Diego , CA 92123 Under: Army Contract No. DAAK70-84-C-0066 0 TABLE OF CONTENTS _Section Page 1 INTRODUCTION TO ANALYSIS 3...below its abso- lute maximum ratings. * a S 41 V REFERENCES 1. L.D. Cotter, S.R. Landa , and V.A... van Lint, "EMP Analysis of TCU and GCU in the

  17. Atlas of Great Comets

    Science.gov (United States)

    Stoyan, Ronald; Dunlop, Storm

    2015-01-01

    Foreword; Using this book; Part I. Introduction: Cometary beliefs and fears; Comets in art; Comets in literature and poetry; Comets in science; Cometary science today; Great comets in antiquity; Great comets of the Middle Ages; Part II. The 30 Greatest Comets of Modern Times: The Great Comet of 1471; Comet Halley 1531; The Great Comet of 1556; The Great Comet of 1577; Comet Halley, 1607; The Great Comet of 1618; The Great Comet of 1664; Comet Kirch, 1680; Comet Halley, 1682; The Great Comet of 1744; Comet Halley, 1759; Comet Messier, 1769; Comet Flaugergues, 1811; Comet Halley, 1835; The Great March Comet of 1843; Comet Donati, 1858; Comet Tebbutt, 1861; The Great September Comet of 1882; The Great January Comet of 1910; Comet Halley, 1910; Comet Arend-Roland, 1956; Comet Ikeya-Seki, 1965; Comet Bennett, 1970; Comet Kohoutek, 1973-4; Comet West, 1976; Comet Halley, 1986; Comet Shoemaker-Levy 9, 1994; Comet Hyakutake, 1996; Comet Hale-Bopp, 1997; Comet McNaught, 2007; Part III. Appendices; Table of comet data; Glossary; References; Photo credits; Index.

  18. Improving mapping and SNP-calling performance in multiplexed targeted next-generation sequencing

    Directory of Open Access Journals (Sweden)

    ElSharawy Abdou

    2012-08-01

    Full Text Available Abstract Background Compared to classical genotyping, targeted next-generation sequencing (tNGS can be custom-designed to interrogate entire genomic regions of interest, in order to detect novel as well as known variants. To bring down the per-sample cost, one approach is to pool barcoded NGS libraries before sample enrichment. Still, we lack a complete understanding of how this multiplexed tNGS approach and the varying performance of the ever-evolving analytical tools can affect the quality of variant discovery. Therefore, we evaluated the impact of different software tools and analytical approaches on the discovery of single nucleotide polymorphisms (SNPs in multiplexed tNGS data. To generate our own test model, we combined a sequence capture method with NGS in three experimental stages of increasing complexity (E. coli genes, multiplexed E. coli, and multiplexed HapMap BRCA1/2 regions. Results We successfully enriched barcoded NGS libraries instead of genomic DNA, achieving reproducible coverage profiles (Pearson correlation coefficients of up to 0.99 across multiplexed samples, with Conclusions We recommend applying our general ‘two-step’ mapping approach for more efficient SNP discovery in tNGS. Our study has also shown the benefit of computing inter-sample SNP-concordances and inspecting read alignments in order to attain more confident results.

  19. Improvement of the design and generation of highly specific plant knockdown lines using primary synthetic microRNAs (pri-smiRNAs

    Directory of Open Access Journals (Sweden)

    Alves Leonardo

    2010-03-01

    Full Text Available Abstract Background microRNAs (miRNAs are endogenous small non-coding RNAs that post-transcriptionally regulate gene expression. In plants, they typically show high complementarity to a single sequence motif within their target mRNAs and act by catalyzing specific mRNA cleavage and degradation. miRNAs are processed from much longer primary transcripts via precursor miRNAs containing fold-back structures. Leaving these secondary structures intact, miRNAs can be re-designed experimentally to target mRNAs of choice. Results We designed primary synthetic miRNAs (pri-smiRNAs on the basis of the primary transcript of the Arabidopsis MIR159A gene by replacing the original miR159a and the corresponding miR159a* with novel sequences, keeping the overall secondary structure as predicted by the program RNAfold. We used the program RNAhybrid to optimize smiRNA design and to screen the complete Arabidopsis transcriptome for potential off-targets. To improve the molecular cloning of the pri-smiRNA we inserted restriction sites in the original MIR159A primary transcript to easily accommodate the smiRNA/smiRNA* DNA fragment. As a proof-of-concept, we targeted the single gene encoding chalcone synthase (CHS in Arabidopsis. We demonstrate smiRNA(CHS expression and CHS mRNA cleavage in different transgenic lines. Phenotypic changes in these lines were observed for seed color and flavonol derivatives, and quantified with respect to anthocyanin content. We also tested the effect of mismatches and excess G:U base pairs on knockdown efficiency. Conclusions RNAhybrid-assisted design of smiRNAs and generation of pri-smiRNAs using a novel vector containing restriction sites greatly improves specificity and speed of the generation of stable knockdown lines for functional analyses in plants.

  20. Improving biomass resource recycling capacity of Rubrivivax gelatinosus cultivated in wastewater through regulating the generation and use of energy.

    Science.gov (United States)

    Wu, Pan; Wang, Yan-ling; Zhang, Guang-ming; Liu, Xian-shu; Du, Cong; Tong, Qing-yue; Li, Ning

    2014-01-01

    This paper investigated Mg2+ enhancement of biomass production through regulating the generation and use of energy in Rubrivivax gelatinosus wastewater treatment. Results showed that proper Mg2+ dosage range was 1.5-15 mg/L. With optimal Mg2+ dosage (10 mg/L), biomass production (5010 mg/L) was improved by 60%. Both protein and chemical oxygen demand (COD) removals reached above 90%. Biomass yield improved by 38%. Hydraulic retention time was shortened by 25%. Mechanism analysis indicated that as activator, Mg2+ promoted specifically isocitrate dehydrogenase (IDH) and Ca2+ / Mg2+ -ATPase activities in energy metabolism, and then improved the generation of adenosine triphosphate (ATP) and the use of ATP. This enhanced the secretion and activity of protease, protein and COD removals, and then led to more biomass production. With 10 mg/L Mg2+, IDH and Ca2+ / Mg2+ -ATPase activities, ATP production, protease activity were improved by 43.8%, 40.6%, 39.4% and 46.5%, respectively.

  1. An Improved Algorithm to Generate a Wi-Fi Fingerprint Database for Indoor Positioning

    Directory of Open Access Journals (Sweden)

    Zhengqi Zheng

    2013-08-01

    Full Text Available The major problem of Wi-Fi fingerprint-based positioning technology is the signal strength fingerprint database creation and maintenance. The significant temporal variation of received signal strength (RSS is the main factor responsible for the positioning error. A probabilistic approach can be used, but the RSS distribution is required. The Gaussian distribution or an empirically-derived distribution (histogram is typically used. However, these distributions are either not always correct or require a large amount of data for each reference point. Double peaks of the RSS distribution have been observed in experiments at some reference points. In this paper a new algorithm based on an improved double-peak Gaussian distribution is proposed. Kurtosis testing is used to decide if this new distribution, or the normal Gaussian distribution, should be applied. Test results show that the proposed algorithm can significantly improve the positioning accuracy, as well as reduce the workload of the off-line data training phase.

  2. AN IMPROVEMENT ON GEOMETRY-BASED METHODS FOR GENERATION OF NETWORK PATHS FROM POINTS

    Directory of Open Access Journals (Sweden)

    Z. Akbari

    2014-10-01

    Full Text Available Determining network path is important for different purposes such as determination of road traffic, the average speed of vehicles, and other network analysis. One of the required input data is information about network path. Nevertheless, the data collected by the positioning systems often lead to the discrete points. Conversion of these points to the network path have become one of the challenges which different researchers, presents many ways for solving it. This study aims at investigating geometry-based methods to estimate the network paths from the obtained points and improve an existing point to curve method. To this end, some geometry-based methods have been studied and an improved method has been proposed by applying conditions on the best method after describing and illustrating weaknesses of them.

  3. An Improved Algorithm for Generating Database Transactions from Relational Algebra Specifications

    Directory of Open Access Journals (Sweden)

    Daniel J. Dougherty

    2010-03-01

    Full Text Available Alloy is a lightweight modeling formalism based on relational algebra. In prior work with Fisler, Giannakopoulos, Krishnamurthi, and Yoo, we have presented a tool, Alchemy, that compiles Alloy specifications into implementations that execute against persistent databases. The foundation of Alchemy is an algorithm for rewriting relational algebra formulas into code for database transactions. In this paper we report on recent progress in improving the robustness and efficiency of this transformation.

  4. Successful universities towards the improvement of regional competitiveness: 'Fourth Generation' universities

    OpenAIRE

    Lukovics, Miklós; Zuti, Bence

    2013-01-01

    Nowadays several successful examples prove that universities have a quite intense role in the improvement of competitiveness of certain territories and in many cases they have an active role in endeavors regarding economic development. Modern economic development demands that due to the increased social and economic commitments the traditional (education and research) activities of the universities should broaden. To be able to exploit their optimal potential regarding economic de...

  5. Improving Aerosol and Visibility Forecasting Capabilities Using Current and Future Generations of Satellite Observations

    Science.gov (United States)

    2015-08-27

    indicate that the assimilation of satellite observations significantly improves NAAPS aerosol forecasting capability and reliability. To fully utilize...method derives a semi-quantitative indicator of nighttime x using artificial light sources. Nighttime x retrievals from the newly-developed method are...Kemper, T. Craig, I. Ginis , Evaluation of Maine aerosol production simulated using the WaveWatchlll prognostic Wave Model coupled to the Community

  6. Standardization of Buckypaper composite actuator fabrication process and improvement of force generation

    Science.gov (United States)

    DeGraff, Joshua

    The Buckypaper/Nafion composite actuator (BCA) is promising for lightweight and micro-robotic system applications. Lightweight BCA provides an energy-efficient and flexible design to achieve muscle-like actuation for micro-actuator applications. The BCA encompasses of a solid Nafion electrolyte stacked between two conductive carbon nanotube thin thins or Buckypaper (BP) sheets. As an ionic electro-active polymer (iEAP), Nafion's response to an electrical signal is similar to the electrochemical response of biological muscles. The adhesion between the electrolyte film and the electrode materials is critical to the actuator performance. BCA manufacturing avoids the complexities of repetitive metallic plating, as BP supplies a high surface area film of conductive carbon nanotubes. Since the actuator's charging occurs where the constituent materials come in contact, a standard manufacturing process needs to be developed to ensure repeatability. This research includes two focuses. The first focus pertains to optimizing the ion-exchange processes that improve Nafion's ionic transport properties. The second focus is to strengthening the interaction between Nafion and Buckypaper, which will ensure effective charge accumulation at the interface and improve the BCA's mechanical properties relevant to force exertion. The research presents a novel BCA manufacturing approach to achieve excellent repeatability and significantly improves the BCA's mechanical properties.

  7. Improving the realism of gravity waves generated by convection in numerical models

    Science.gov (United States)

    Stephan, Claudia Christine

    Small-scale gravity waves (GWs) with horizontal wavelengths of tens up to several hundred kilometers have demonstrated importance for driving the general circulation of the atmosphere, which affects many climate processes. GWs that propagate vertically from the troposphere into the middle atmosphere eventually dissipate and deposit momentum to the mean flow. Through this process they influence the timing of the transition in springtime from winter westerlies to summer easterlies in the stratosphere. They also play an important role in driving the mean-meridional transport circulation, the Brewer-Dobson circulation, and in the tropics help drive the Quasi-Biennial Oscillation and the Semi-Annual Oscillation. GWs with scales on the order of the size of a model grid box or smaller remain unresolved in Global Circulation Models (GCMs) and therefore need to be parameterized. GWs are generated by a variety of sources including orography, convection, and geostrophic adjustment in regions of baroclinic instability. We focus here in particular on convectively-generated GWs, which are prevalent in the tropics and summer mid-latitudes. Their parameterizations in climate models range in complexity from simple assumptions of uniform sources to more complex methods that relate the spectrum of GWs to properties of convection in the climate model. The parameter settings that must be chosen to apply these GW parameterizations are poorly constrained by observations, so they are instead based largely on cloud-resolving model results. Cloud-resolving model studies themselves use parameterized physics for the microphysics of precipitation particle formation. We first explore the sensitivity of the waves generated in cloud-resolving models to these physics parameterizations and show that knowledge of large-scale storm conditions is sufficient to predict the large-area and time-average spectrum of GW momentum flux above storms, irrespective of the convective details that coarse

  8. Automatic Optimizer Generation Method Based on Location and Context Information to Improve Mobile Services

    Directory of Open Access Journals (Sweden)

    Yunsik Son

    2017-01-01

    Full Text Available Several location-based services (LBSs have been recently developed for smartphones. Among these are proactive LBSs, which provide services to smartphone users by periodically collecting background logs. However, because they consume considerable battery power, they are not widely used for various LBS-based services. Battery consumption, in particular, is a significant issue on account of the characteristics of mobile systems. This problem involves a greater service restriction when performing complex operations. Therefore, to successfully enable various services based on location, this problem must be solved. In this paper, we introduce a technique to automatically generate a customized service optimizer for each application, service type, and platform using location and situation information. By using the proposed technique, energy and computing resources can be more efficiently employed for each service. Thus, users should receive more effective LBSs on mobile devices, such as smartphones.

  9. Performance of an improved first generation optical CT scanner for 3D dosimetry.

    Science.gov (United States)

    Qian, Xin; Adamovics, John; Wuu, Cheng-Shie

    2013-12-21

    Performance analysis of a modified 3D dosimetry optical scanner based on the first generation optical CT scanner OCTOPUS is presented. The system consists of PRESAGE dosimeters, the modified 3D scanner, and a new developed in-house user control panel written in Labview program which provides more flexibility to optimize mechanical control and data acquisition technique. The total scanning time has been significantly reduced from initial 8 h to ∼2 h by using the modified scanner. The functional performance of the modified scanner has been evaluated in terms of the mechanical integrity uncertainty of the data acquisition process. Optical density distribution comparison between the modified scanner, OCTOPUS and the treatment plan system has been studied. It has been demonstrated that the agreement between the modified scanner and treatment plans is comparable with that between the OCTOPUS and treatment plans.

  10. NWTC Aerodynamics Studies Improve Energy Capture and Lower Costs of Wind-Generated Electricity

    Energy Technology Data Exchange (ETDEWEB)

    2015-08-01

    Researchers at the National Wind Technology Center (NWTC) at the National Renewable Energy Laboratory (NREL) have expanded wind turbine aerodynamic research from blade and rotor aerodynamics to wind plant and atmospheric inflow effects. The energy capture from wind plants is dependent on all of these aerodynamic interactions. Research at the NWTC is crucial to understanding how wind turbines function in large, multiple-row wind plants. These conditions impact the cumulative fatigue damage of turbine structural components that ultimately effect the useful lifetime of wind turbines. This work also is essential for understanding and maximizing turbine and wind plant energy production. Both turbine lifetime and wind plant energy production are key determinants of the cost of wind-generated electricity.

  11. Simulated Annealing Based Hybrid Forecast for Improving Daily Municipal Solid Waste Generation Prediction

    Directory of Open Access Journals (Sweden)

    Jingwei Song

    2014-01-01

    Full Text Available A simulated annealing (SA based variable weighted forecast model is proposed to combine and weigh local chaotic model, artificial neural network (ANN, and partial least square support vector machine (PLS-SVM to build a more accurate forecast model. The hybrid model was built and multistep ahead prediction ability was tested based on daily MSW generation data from Seattle, Washington, the United States. The hybrid forecast model was proved to produce more accurate and reliable results and to degrade less in longer predictions than three individual models. The average one-week step ahead prediction has been raised from 11.21% (chaotic model, 12.93% (ANN, and 12.94% (PLS-SVM to 9.38%. Five-week average has been raised from 13.02% (chaotic model, 15.69% (ANN, and 15.92% (PLS-SVM to 11.27%.

  12. Genetic manipulation of ligninolytic streptomyces and generation of improved lignin-to-chemical bioconversion strains

    Energy Technology Data Exchange (ETDEWEB)

    Crawford, D.L.; Pettey, T.M.; Thede, B.M.; Deobald, L.A.

    1984-01-01

    Streptomyces viridosporus T7A, when used in solid-state fermentation, degrades lignin at high yields to a water-soluble modified polymer, acid precipitable polymeric lignin (APPL) that is useful as an antioxidant, surfactant, and potentially as a component of adhesives and resins. Enhanced strains generated from ultraviolet irradiation mutagenesis and protoplast fusion produced up to 90% more APPL from corn stover lignocellulose than did the wildtype, and they were stable and produced APPL at a faster rate and to a higher final yield than did parental strain T7A. APPLs produced by the wildtype and selected mutants were chemicaly similar polyphenols, but some catabolic enzymes of the genetically manipulated strains were produced in greater amounts.

  13. Carnation-like MnO2 modified activated carbon air cathode improve power generation in microbial fuel cells

    Science.gov (United States)

    Zhang, Peng; Li, Kexun; Liu, Xianhua

    2014-10-01

    Highly active and low-cost electrocatalysts are of great importance for large-scale commercial applications of microbial fuel cells (MFCs). In this work, we prepared an activated carbon (AC) air cathode containing electrodeposited γ-MnO2 using a potentiostatic method. The results indicated that carnation-like MnO2 crystals were bound to the surface of the AC air cathode after a deposition time of 10 min, which greatly improved the performance of the cathode. BET analysis results demonstrated that the electrodeposition of MnO2 decreased the micropore surface area of the cathode but increased the mesopore surface area. When compared with a bare AC air cathode, the electrodeposited MnO2 cathode exhibited higher catalytic activity for oxygen reduction reaction. The maximum power density of the MFC equipped with the electrodeposited MnO2 AC air cathode was 1554 mW m-2, which is 1.5 times higher than the control cathode.

  14. OH radicals generated by DC corona discharge for improving the pulsed discharge desulfuration efficiency

    Institute of Scientific and Technical Information of China (English)

    LI Jie; LI Guo-feng; WU Yan; WANG Ning-hui; HUANG Qiu-nan

    2004-01-01

    Positive DC corona discharge is formed with needle-plate electrode configuration, in which the water vapor is ejected though the needle points. The purpose is to increase the numbers of the water-based radicals, ionize the water molecule and improve the desulfuration efficiency of pulsed corona reactor. The water ions were determined by four stages molecular beam mass spectrometer and diagnose the water-based radicals by emission spectrograph. A conclusion on formation of ions and radicals with DC corona discharges can be drawn.

  15. Failure, The Next Generation: Why Rigorous Standards are not Sufficient to Improve Science Learning

    Directory of Open Access Journals (Sweden)

    Mary Antony Bair

    2014-11-01

    Full Text Available Although many states in the United States are adopting policies that require all students to complete college-preparatory science classes to graduate from high school, such policies have not always led to improved student outcomes. There is much speculation about the cause of the dismal results, but there is scant research on the processes by which the policies are being implemented at the school level, especially in schools that enroll large numbers of historically non-college-bound students. To address this gap in the literature, we conducted a four-year ethnographic case study of policy implementation at one racially and socioeconomically diverse high school in Michigan. Guided by the structuration theory of Anthony Giddens (1984, we gathered and analyzed information from interviews with administrators and science teachers, observations of science classes, and relevant curriculum and policy documents. Our findings reveal the processes and rationales by which a state policy mandating three years of college-preparatory science for all students was implemented at the school. Four years after the policy was implemented, there was little improvement in science outcomes. The main reason for this, we found, was the lack of correspondence between the state policy and local policies developed in response to that state policy.

  16. An improvement in perception of self-generated tactile stimuli following theta-burst stimulation of primary motor cortex

    Science.gov (United States)

    Voss, Martin; Bays, Paul M.; Rothwell, John C.; Wolpert, Daniel M.

    2007-01-01

    Recent studies have shown that self-generated tactile sensations are perceived as weaker than the same sensations externally generated. This has been linked to a central comparator mechanism that uses efference copy to attenuate the predictable component of sensory inputs arising from one's own actions in order to enhance the salience of external stimuli. To provide a quantitative measure of this attenuation, a force-matching task was developed in which subjects experience a force applied to their finger and are then required to match the perceived force by actively pushing on the finger using their other hand. The attenuation of predictable sensory input results in subjects producing a larger active force than was experienced passively. Here, we have examined the effects of a novel rTMS protocol, theta-burst stimulation (TBS), over primary motor cortex on this attenuation. TBS can alter the excitability of motor cortex to incoming activity. We show that application of a 20 s continuous train of TBS, that depresses motor cortex, significantly improves performance in a force-matching task. This suggests that the TBS intervention disturbed the predictive process that uses efference copy signals to attenuate predictable sensory input. A possible explanation for the effect is that TBS has a differential effect on the populations of neurones that generate motor output in M1 than on those neural structures that are involved in generating an efference copy of the motor command. PMID:17560617

  17. A combined supplementation of vitamin B12 and omega-3 fatty acids across two generations improves cardiometabolic variables in rats.

    Science.gov (United States)

    Khaire, Amrita; Rathod, Richa; Randhir, Karuna; Kale, Anvita; Joshi, Sadhana

    2016-09-14

    Our earlier studies indicate that micronutrients (vitamin B12, folic acid) and omega-3 fatty acids especially docosahexaenoic acid (DHA) are interlinked in one carbon cycle. The present study examines the effects of a sustained vitamin B12 deficiency/supplementation in the presence of omega-3 fatty acids across two generations on the pregnancy outcome and cardiometabolic profile [blood pressure, plasma lipid profile (cholesterol and triglycerides), plasma/liver fatty acid profile and hepatic lipid metabolism] in the second generation adult Wistar rat offspring. Two generations of animals were fed the following diets: control; vitamin B12 deficient; vitamin B12 supplemented; vitamin B12 deficient diet supplemented with omega-3 fatty acids; vitamin B12 and omega-3 fatty acid supplemented diets. Male offspring were sacrificed at 3 months of age. Vitamin B12 deficiency lowered the weight gain (p B12 supplementation showed weight gain, blood pressure and the fatty acid profile similar to the control. However, it increased (p B12 deficient group lowered the weight gain although the levels of cardiometabolic variables were comparable to the control. Omega-3 fatty acid supplementation in the presence of vitamin B12 improved the pregnancy outcome and all cardio-metabolic variables. Our study highlights the adverse effects of sustained vitamin B12 deficiency across two generations on the pregnancy outcome, fatty acid profile and blood pressure while a combined supplementation of vitamin B12 and omega-3 fatty acids is beneficial.

  18. Identification of Reserved Energy Resource Potentials for Nigeria Power Generation Improvement

    Directory of Open Access Journals (Sweden)

    I. O. Akwukwaegbu

    2016-09-01

    Full Text Available Electrical power is the most widely used form of power in the industrialized countries. In Nigeria the epileptic pattern of electricity supply has affected every aspect of our economy and therefore required a strong political will and commitment on the part of Government to tackle. The solution to this problem lies in identifying and harnessing the abundant reserve energy resources available in various locations all over the country. This paper thus dwelt on identifying various sources of reserve energy potentials that abound in Nigeria which when harnessed and deployed appropriately will be sufficient to provide for both immediate and future electric power need of the country. The approach deployed in the study include the review of available statistical data of Nigeria reserve energy resources; identify the scale of its availability, location and the realizable amount of electric power from such reserve. The results show that the proven and estimated reserved energy resources of coal, natural gas and new hydro potentials could contribute a total of 96,079.40MW to the grid system, and when added to the existing installed electric power generation capacity of 12,066MW will give a total of 108,145.40MW

  19. Improvement of Point Lepreau Generating Station ROP detector characteristics by adjusting gains in compensation amplifiers

    Energy Technology Data Exchange (ETDEWEB)

    Anghel, V., E-mail: vinicius.anghel@cnl.ca [Canadian Nuclear Laboratories, Chalk River, Ontario (Canada); Basque, M.-J. [Atlantic Nuclear Services Inc., Fredericton, New Brunswick (Canada); Comeau, D. [Point Lepreau Generating Station, Lepreau, New Brunswick (Canada); Sur, B. [Canadian Nuclear Laboratories, Chalk River, Ontario (Canada); Taylor, D. [Point Lepreau Generating Station, Lepreau, New Brunswick (Canada)

    2015-06-15

    Canadian Pressurized Heavy Water Reactors are protected against reactor overpower by 2 independent shutdown systems: Shut Down System 1 and 2. At Point Lepreau Generating Station, these shutdown systems can be actuated by signals from Platinum-clad Inconel In-Core Flux Detectors measuring the neutron flux. These detectors have a complex dynamic behaviour, characterized by 'prompt' and 'delayed' components with respect to immediate changes in the in-core neutron flux. In aging detectors, it was found that the prompt response decreases. A detector response that actuates the shutdown system effectively has to have a large prompt response and a small delayed response. These required responses may be obtained by adjusting the dynamic compensation amplifiers (compensator) settings. This paper presents the measured results of a compensation adjustment procedure for the in-core platinum-clad Inconel detectors. The compensation is computed from the detector parameters estimated by VS, a fully automated and qualified computer program that analyzes the response of the detectors. (author)

  20. Use of speech generating devices can improve perception of qualifications for skilled, verbal, and interactive jobs.

    Science.gov (United States)

    Stern, Steven E; Chobany, Chelsea M; Beam, Alexander A; Hoover, Brittany N; Hull, Thomas T; Linsenbigler, Melissa; Makdad-Light, Courtney; Rubright, Courtney N

    2017-01-01

    We have previously demonstrated that when speech generating devices (SGD) are used as assistive technologies, they are preferred over the users' natural voices. We sought to examine whether using SGDs would affect listener's perceptions of hirability of people with complex communication needs. In a series of three experiments, participants rated videotaped actors, one using SGD and the other using their natural, mildly dysarthric voice, on (a) a measurement of perceptions of speaker credibility, strength, and informedness and (b) measurements of hirability for jobs coded in terms of skill, verbal ability, and interactivity. Experiment 1 examined hirability for jobs varying in terms of skill and verbal ability. Experiment 2 was a replication that examined hirability for jobs varying in terms of interactivity. Experiment 3 examined jobs in terms of skill and specific mode of interaction (face-to-face, telephone, computer-mediated). Actors were rated more favorably when using SGD than their own voices. Actors using SGD were also rated more favorably for highly skilled and highly verbal jobs. This preference for SGDs over mildly dysarthric voice was also found for jobs entailing computer-mediated-communication, particularly skillful jobs.

  1. Improvements on non-equilibrium and transport Green function techniques: The next-generation TRANSIESTA

    Science.gov (United States)

    Papior, Nick; Lorente, Nicolás; Frederiksen, Thomas; García, Alberto; Brandbyge, Mads

    2017-03-01

    We present novel methods implemented within the non-equilibrium Green function code (NEGF) TRANSIESTA based on density functional theory (DFT). Our flexible, next-generation DFT-NEGF code handles devices with one or multiple electrodes (Ne ≥ 1) with individual chemical potentials and electronic temperatures. We describe its novel methods for electrostatic gating, contour optimizations, and assertion of charge conservation, as well as the newly implemented algorithms for optimized and scalable matrix inversion, performance-critical pivoting, and hybrid parallelization. Additionally, a generic NEGF ;post-processing; code (TBTRANS/PHTRANS) for electron and phonon transport is presented with several novelties such as Hamiltonian interpolations, Ne ≥ 1 electrode capability, bond-currents, generalized interface for user-defined tight-binding transport, transmission projection using eigenstates of a projected Hamiltonian, and fast inversion algorithms for large-scale simulations easily exceeding 106 atoms on workstation computers. The new features of both codes are demonstrated and bench-marked for relevant test systems.

  2. Transient Performance Improvement of Wind Turbines with Doubly Fed Induction Generators Using Active Damping Control Strategy

    Directory of Open Access Journals (Sweden)

    Saeed Soleymani

    2016-01-01

    Full Text Available This paper Analytically investigates the effects of system and controller parameters and operating conditions on the dynamic and transient behavior of wind turbines (WTs with doubly-fed induction generators (DFIGs under voltage dips and wind speed fluctuations. Also, it deals with the design considerations regarding rotor and speed controllers. The poorly damped electrical and mechanical modes of the system are identified, and the effects of system parameters, and speed/rotor controllers on these modes are investigated by modal and sensitivity analyses. The results of theoretical studies are verified by time domain simulations. It is found that the dynamic behavior of the DFIG-based WT under voltage dips is strongly affected by the stator dynamics. Further, it is shown that the closed loop bandwidth of the rotor current control, rotor current damping, DFIG power factor and the rotor back-emf voltages have high impact on the stator modes and consequently on the DFIG dynamic behavior. Moreover, it is shown that the dynamic behavior of DFIG-based WT under wind speed fluctuation is significantly dependent on the bandwidth and damping of speed control loop.

  3. Evaluation of breast cancer susceptibility using improved genetic algorithms to generate genotype SNP barcodes.

    Science.gov (United States)

    Yang, Cheng-Hong; Lin, Yu-Da; Chuang, Li-Yeh; Chang, Hsueh-Wei

    2013-01-01

    Genetic association is a challenging task for the identification and characterization of genes that increase the susceptibility to common complex multifactorial diseases. To fully execute genetic studies of complex diseases, modern geneticists face the challenge of detecting interactions between loci. A genetic algorithm (GA) is developed to detect the association of genotype frequencies of cancer cases and noncancer cases based on statistical analysis. An improved genetic algorithm (IGA) is proposed to improve the reliability of the GA method for high-dimensional SNP-SNP interactions. The strategy offers the top five results to the random population process, in which they guide the GA toward a significant search course. The IGA increases the likelihood of quickly detecting the maximum ratio difference between cancer cases and noncancer cases. The study systematically evaluates the joint effect of 23 SNP combinations of six steroid hormone metabolisms, and signaling-related genes involved in breast carcinogenesis pathways were systematically evaluated, with IGA successfully detecting significant ratio differences between breast cancer cases and noncancer cases. The possible breast cancer risks were subsequently analyzed by odds-ratio (OR) and risk-ratio analysis. The estimated OR of the best SNP barcode is significantly higher than 1 (between 1.15 and 7.01) for specific combinations of two to 13 SNPs. Analysis results support that the IGA provides higher ratio difference values than the GA between breast cancer cases and noncancer cases over 3-SNP to 13-SNP interactions. A more specific SNP-SNP interaction profile for the risk of breast cancer is also provided.

  4. A New Reference Signal Generation and DC-link Control for Fault Mitigation and Power Quality Improvement of DFIG

    Directory of Open Access Journals (Sweden)

    P.T. Rajan

    2015-07-01

    Full Text Available This study delivers a new approach for reference signal generation to improve the power quality problem of Doubly Fed Induction Generator (DFIG. DFIG consists of RSC (Rotor Side Converter and GSC (Grid Side Converter and common DC-Link. RSC converter used to mitigate the sag and swell compensation by enhanced phase lock loop and variable speed Limit. The aim of GSC is to mitigate the current harmonics and load balancing control by non-linear adaptive filter approach. The 60% of DC-Link voltage control obtained by GSC and remaining 40% of sag is controlled by the external chopper through the DC-Link voltage balancing. Additional chopper is presented to reduce the size, stress of DC-Link capacitor and also it avoids additional control loop in GSC. The system power qualities are verified through simulation studies.

  5. Options to Improve the Quality of Wind Generation Output Forecasting with the Use of Available Information as Explanatory Variables

    Directory of Open Access Journals (Sweden)

    Rafał Magulski

    2015-06-01

    Full Text Available Development of wind generation, besides its positive aspects related to the use of renewable energy, is a challenge from the point of view of power systems’ operational security and economy. The uncertain and variable nature of wind generation sources entails the need for the for the TSO to provide adequate reserves of power, necessary to maintain the grid’s stable operation, and the actors involved in the trading of energy from these sources incur additional of balancing unplanned output deviations. The paper presents the results of analyses concerning the options to forecast a selected wind farm’s output exercised by means of different methods of prediction, using a different range of measurement and forecasting data available on the farm and its surroundings. The analyses focused on the evaluation of forecast errors, and selection of input data for forecasting models and assessment of their impact on prediction quality improvement.

  6. Using HYSPLIT Generated Ensembles to Improve the Simulation of Plume Dispersion and Assess Model Uncertainty.

    Science.gov (United States)

    Chai, T.; Stein, A. F.; Ngan, F.

    2016-12-01

    Over the last few years, the use of dispersion model ensembles has become an increasingly attractive approach to study atmospheric transport in the lower troposphere. The HYSPLIT modeling system has a built-in capability to produce three different simulation ensembles. These ensembles have been constructed based on applied case studies using different sets of initial conditions and internal model physical parameters. They are not meant to be comprehensive and only account for some of the components of the concentration uncertainty. The first one, called "Meteorological Grid" ensemble, is created by slightly offsetting the meteorological data to test the sensitivity of the advection calculation to the gradients in the meteorological data fields. The rationale for the shifting is to assess the effect that a limited spatial and temporal resolution meteorological data field has on the output concentration. The second, called the "Turbulence" ensemble, represents the uncertainty in the concentration calculation arising from the model's discrete characterization of the turbulent random motions of its lagrangian particles. In this ensemble approach, the number of particles released is reduced and multiple simulations are run, each with a different random number seed. The third, the "Physics" ensemble, is constructed by varying key physical model parameters and model options such as the Lagrangian representation of the particles/puffs, Lagrangian timescales, and vertical and horizontal dispersion parameterizations. One of the biggest challenges in creating dispersion ensembles is developing the appropriate member selection process to get the most accurate results, quantify ensemble uncertainty, and use computing resources more efficiently by avoiding the use of redundant model information. In this work, we use the HYSPLIT modeling system to generate ensembles and evaluate them against the Cross-Appalachian Tracer Experiment (CAPTEX). Furthermore, we apply a reduction

  7. Transient Response Improvement of Microgrids Exploiting the Inertia of a Doubly-Fed Induction Generator (DFIG

    Directory of Open Access Journals (Sweden)

    Christina N. Papadimitriou

    2010-06-01

    Full Text Available Storage devices are introduced in microgrids in order to secure their power quality, power regularity and offer ancillary services in a transient period. In the transition period of a low voltage microgrid, from the connected mode of operation to the islanded mode of operation, the power unbalance can be partly covered by the inertia energy of the existing power sources. This paper proposes fuzzy local controllers exploiting the inertia of a Wind Turbine (WT with a Doubly Fed Induction Generator (DFIG, if such a machine exists in the microgrid, in order to decrease the necessary storage devices and the drawbacks that arise. The proposed controllers are based in fuzzy logic due to the non linear and stochastic behavior of the system. Two cases are studied and compared during the transient period where the microgrid architecture and the DFIG controller differ. In the first case, the understudy microgrid includes a hybrid fuel cell system (FCS-battery system and a WT with a DFIGURE. The DFIG local controller in this case is also based in fuzzy logic and follows the classical optimum power absorption scenario for the WT. The transition of the microgrid from the connected mode of operation to the islanded mode is evaluated and, especially, the battery contribution is estimated. In the second case, the battery is eliminated. The fuzzy controller of the DFIG during the transition provides primary frequency control and local bus voltage support exploiting the WT inertia. The response of the system is estimated in both cases using MATLAB/Simulink software package.

  8. Aquatic Trash Prevention National Great Practices Compendium

    Science.gov (United States)

    The National Great Practice Compendium highlights outstanding activities, technologies, and programs that prevent trash from entering the aquatic environment and/or that reduce the overall volume of trash that is generated.

  9. Great attractor really a great wall

    Energy Technology Data Exchange (ETDEWEB)

    Stebbins, A.; Turner, M.S.

    1988-11-01

    Some of the cosmological consequences are discussed of a late time phase transition which produces light domain walls. The observed peculiar velocity field of the Universe and the observed isotropy of the microwave background radiation severely constrain the wall surface density in such a scenario. The most interesting consequence of such a phase transition is the possibility that the local, coherent streaming motion reported by the Seven Samurai could be explained by the repulsive effect of a relic domain wall with the Hubble volume (the Great Wall).

  10. Colloidal gold nanorings for improved photodynamic therapy through field-enhanced generation of reactive oxygen species

    Science.gov (United States)

    Hu, Yue; Yang, Yamin; Wang, Hongjun; Du, Henry

    2013-02-01

    Au nanostructures that exhibit strong localized surface plasmon resonance (SPR) have excellent potential for photo-medicine, among a host of other applications. Here, we report the synthesis and use of colloidal gold nanorings (GNRs) with potential for enhanced photodynamic therapy of cancer. The GNRs were fabricated via galvanic replacement reaction of sacrificial Co nanoparticles in gold salt solution with low molecular weight (Mw = 2,500) poly(vinylpyrrolidone) (PVP) as a stabilizing agent. The size and the opening of the GNRs were controlled by the size of the starting Co particles and the concentration of the gold salt. UV-Vis absorption measurements indicated the tunability of the SPR of the GNRs from 560 nm to 780 nm. MTT assay showed that GNRs were non-toxic and biocompatible when incubated with breast cancer cells as well as the healthy counterpart cells. GNRs conjugated with 5-aminolevulinic acid (5-ALA) photosensitizer precursor led to elevated formation of reactive oxygen species and improved efficacy of photodynamic therapy of breast cancer cells under light irradiation compared to 5-ALA alone. These results can be attributed to significantly enhance localized electromagnetic field of the GNRs.

  11. Thermal Test of an Improved Platform for Silicon Nanowire-Based Thermoelectric Micro-generators

    Science.gov (United States)

    Calaza, C.; Fonseca, L.; Salleras, M.; Donmez, I.; Tarancón, A.; Morata, A.; Santos, J. D.; Gadea, G.

    2016-03-01

    This work reports on an improved design intended to enhance the thermal isolation between the hot and cold parts of a silicon-based thermoelectric microgenerator. Micromachining techniques and silicon on insulator substrates are used to obtain a suspended silicon platform surrounded by a bulk silicon rim, in which arrays of bottom-up silicon nanowires are integrated later on to join both parts with a thermoelectric active material. In previous designs the platform was linked to the rim by means of bulk silicon bridges, used as mechanical support and holder for the electrical connections. Such supports severely reduce platform thermal isolation and penalise the functional area due to the need of longer supports. A new technological route is planned to obtain low thermal conductance supports, making use of a particular geometrical design and a wet bulk micromachining process to selectively remove silicon shaping a thin dielectric membrane. Thermal conductance measurements have been performed to analyse the influence of the different design parameters of the suspended platform (support type, bridge/membrane length, separation between platform and silicon rim,) on overall thermal isolation. A thermal conductance reduction from 1.82 mW/K to 1.03 mW/K, has been obtained on tested devices by changing the support type, even though its length has been halved.

  12. Improved Performance of an Indigenous Stirling Type Pulse Tube Cooler and Pressure Wave Generator

    Science.gov (United States)

    Kumar, J. Kranthi; Jacob, S.; Karunanithi, R.; Narasimham, G. S. V. L.; Damu, C.; Praveen, T.; Samir, M.

    Sustained efforts have been made in our laboratory to improve the performance of an indigenously developed pressure wave gen- erator by reducing the mechanical losses and the required input power. An acoustically matching pulse tube cooler, with a design target of 0.5 W at 80 K, was designed using Sage and experience gained from previous studies. The pulse tube cooler was fabri- cated and tested. The effect of regenerator stacking pattern on the cooler performance was studied by filling the regenerator with mesh of the same size #400 and with multi meshes #250, 325, 400. In present experiments, regenerator with #400 mesh at 30 bar filling pressure performed better with more energy efficiency. A no load temperature of 74 K was achieved with input power of 59 W corresponding to a cooling power of 0.22 W at 80 K. Parasitic heat load to the cooler was measured be 0.68 W. This heat load is primarily by heat conduction through the regenerator and pulse tube wall. By reducing the wall thickness from 0.30 mm to 0.15 mm, the parasitic loads can be reduced by 50%.

  13. IMPROVEMENTS FOR THE THIRD GENERATION PLASMA WAKEFIELD EXPERIMENT E-164 AT SLAC

    Energy Technology Data Exchange (ETDEWEB)

    Barnes, C

    2004-09-15

    The E-164 experiment at the Stanford Linear Accelerator Center is the third in a series investigating Plasma Wakefield Acceleration where the wake is driven by electron bunches. A collaboration between SLAC, UCLA and USC, E-164 has up to 2 x 10{sup 10} electrons at 28.5 GeV in 100 micron long bunches. These bunches enter a 30cm long Lithium plasma with density of 6 x 10{sup 15} electrons/cm{sup 3}, where the transfer of energy from the head of the bunch to the tail takes place. In addition to acceleration, strong focusing, refraction of the electron beam and ''betatron X-ray'' production are all investigated. E-164 builds on related prior experiments, and its apparatus has evolved considerably. A third Optical Transition Radiator has been added for real time Twiss Parameter measurements which include the effects of scattering. The plasma cell is moved to the focus of the Final Focus Test Beam facility in order to increase bunch electron density. Spectrometry is extended with an upstream chicane in a dispersive region to produce synchrotron X-rays. Performance of these improvements and status of the experiment are discussed.

  14. Improvement of dem Generation from Aster Images Using Satellite Jitter Estimation and Open Source Implementation

    Science.gov (United States)

    Girod, L.; Nuth, C.; Kääb, A.

    2015-12-01

    The Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) system embarked on the Terra (EOS AM-1) satellite has been a source of stereoscopic images covering the whole globe at a 15m resolution at a consistent quality for over 15 years. The potential of this data in terms of geomorphological analysis and change detection in three dimensions is unrivaled and needs to be exploited. However, the quality of the DEMs and ortho-images currently delivered by NASA (ASTER DMO products) is often of insufficient quality for a number of applications such as mountain glacier mass balance. For this study, the use of Ground Control Points (GCPs) or of other ground truth was rejected due to the global "big data" type of processing that we hope to perform on the ASTER archive. We have therefore developed a tool to compute Rational Polynomial Coefficient (RPC) models from the ASTER metadata and a method improving the quality of the matching by identifying and correcting jitter induced cross-track parallax errors. Our method outputs more accurate DEMs with less unmatched areas and reduced overall noise. The algorithms were implemented in the open source photogrammetric library and software suite MicMac.

  15. Recent SuperB Design Choices Improve Next-Generation e e___ B-Factory Collider

    Energy Technology Data Exchange (ETDEWEB)

    Wittmer, W.; Bertsche, K.; Chao, A.; Novokhatski, A.; Nosochkov, Y.; Seeman, J.; Sullivan, M.K.; Wienands, U.; /SLAC; Bogomyagkov, A.V.; Levichev, E.; Nikitin, S.; Piminov, P.; Shatilov, D.; Sinyatkin, S.; Vobly, P.; Okunev, I.N.; /Novosibirsk, IYF; Bolzon, B.; Brunetti, L.; Jeremie, A.; /Annecy, LAPP; Biagini, M.E.; Boni, R.; /Frascati /INFN, Pisa /Pisa U. /INFN, Genoa /Genoa U. /CERN /Orsay, LAL /Saclay

    2011-08-19

    The SuperB international team continues to optimize the design of an electron-positron collider, which will allow the enhanced study of the origins of flavor physics. The project combines the best features of a linear collider (high single-collision luminosity) and a storage-ring collider (high repetition rate), bringing together all accelerator physics aspects to make a very high luminosity of 10{sup 36} cm{sup -2} sec{sup -1}. This asymmetric-energy collider with a polarized electron beam will produce hundreds of millions of B-mesons at the {Upsilon}(4S) resonance. The present design is based on extremely low emittance beams colliding at a large Piwinski angle to allow very low {beta}*{sub y} without the need for ultra short bunches. Use of crab-waist sextupoles will enhance the luminosity, suppressing dangerous resonances and allowing for a higher beam-beam parameter. The project has flexible beam parameters, improved dynamic aperture, and spin-rotators in the Low Energy Ring for longitudinal polarization of the electron beam at the Interaction Point. Optimized for best colliding-beam performance, the facility may also provide high-brightness photon beams for synchrotron radiation applications.

  16. Next Generation Network Real-Time Kinematic Interpolation Segment to Improve the User Accuracy

    Directory of Open Access Journals (Sweden)

    Mohammed Ouassou

    2015-01-01

    Full Text Available This paper demonstrates that automatic selection of the right interpolation/smoothing method in a GNSS-based network real-time kinematic (NRTK interpolation segment can improve the accuracy of the rover position estimates and also the processing time in the NRTK processing center. The methods discussed and investigated are inverse distance weighting (IDW; bilinear and bicubic spline interpolation; kriging interpolation; thin-plate splines; and numerical approximation methods for spatial processes. The methods are implemented and tested using GNSS data from reference stations in the Norwegian network RTK service called CPOS. Data sets with an average baseline between reference stations of 60–70 km were selected. 12 prediction locations were used to analyze the performance of the interpolation methods by computing and comparing different measures of the goodness of fit such as the root mean square error (RMSE, mean square error, and mean absolute error, and also the computation time was compared. Results of the tests show that ordinary kriging with the Matérn covariance function clearly provides the best results. The thin-plate spline provides the second best results of the methods selected and with the test data used.

  17. Great Lakes Teacher's Guide.

    Science.gov (United States)

    Reid, Ron

    The Great Lakes are one of the world's greatest reservoirs of fresh water, the foundation of Ontario's economic development, a primary force in ecological systems, and a base for pleasure and recreation. They are also a magnificent resource for the teachers of Ontario. Study of the Great Lakes can bring to life the factors that shape the ecology…

  18. Great Principles of Computing

    OpenAIRE

    Denning, Peter J.

    2008-01-01

    The Great Principles of Computing is a framework for understanding computing as a field of science. The website ...April 2008 (Rev. 8/31/08) The Great Principles of Computing is a framework for understanding computing as a field of science.

  19. Improving the Nation's Climate Literacy through the Next Generation Science Standards

    Science.gov (United States)

    Grogan, M.; Niepold, F.; Ledley, T. S.; Gold, A. U.; Breslyn, W. G.; Carley, S.

    2013-12-01

    Climate Literacy: The Essential Principles of Climate Science (2009) presented the information that is deemed important for individuals and communities to know and understand about Earth's climate, impacts of climate change, and approaches to adaptation or mitigation by a group of federal agencies, science and educational partners. These principles guided the development of the NRC Framework for K-12 Science Education: Practices, Crosscutting Concepts, and Core Ideas (2012) and the Next Generation Science Standards (NGSS, 2013). National Science Foundation recently funded two partnership projects which support the implementation of the climate component of the NGSS using the Climate Literacy framework. The first project, the Climate Literacy and Energy Awareness Network (CLEAN), was launched in 2010 as a National Science Digital Library (NSDL) Pathways project. CLEAN's primary effort is to steward a collection of educational resources around energy and climate topics and foster a community that supports learning about climate and energy topics. CLEAN's focus has been to integrate the effective use of the educational resources across all grade levels - with a particular focus on the middle-school through undergraduate levels (grades 6-16) and align the resources with educational standards. The second project, the Maryland and Delaware Climate Change Education, Assessment and Research (MADE-CLEAR) program is supported by a Phase II Climate Change Education Partnership (CCEP) grant awarded to the University System of Maryland (USM) by the National Science Foundation. The MADE-CLEAR project's related goals are to support innovations in interdisciplinary P-20 (preschool through graduate school) climate change education, and develop new pathways for teacher education and professional development leading to expertise in climate change content and pedagogy. Work in Maryland, Delaware (MADE-CLEAR) and other states on the implementation of the NGSS, that will utilize the

  20. Polymer-based protein engineering grown ferrocene-containing redox polymers improve current generation in an enzymatic biofuel cell.

    Science.gov (United States)

    Campbell, Alan S; Murata, Hironobu; Carmali, Sheiliza; Matyjaszewski, Krzysztof; Islam, Mohammad F; Russell, Alan J

    2016-12-15

    Enzymatic biofuel cells (EBFCs) are capable of generating electricity from physiologically present fuels making them promising power sources for the future of implantable devices. The potential application of such systems is limited, however, by inefficient current generation. Polymer-based protein engineering (PBPE) offers a unique method to tailor enzyme function through tunable modification of the enzyme surface with functional polymers. In this study, we report on the modification of glucose oxidase (GOX) with ferrocene-containing redox polymers to increase current generation efficiency in an enzyme-modified anode. Poly(N-(3-dimethyl(ferrocenyl)methylammonium bromide)propyl acrylamide) (pFcAc) was grown from covalently attached, water-soluble initiator molecules on the surface of GOX in a "grafting-from" approach using atom transfer radical polymerization (ATRP). The covalently-coupled ferrocene-containing polymers on the enzyme surface promoted the effective "wiring" of the GOX active site to an external electrode. The resulting GOX-pFcAc conjugates generated over an order of magnitude increase in current generation efficiency and a 4-fold increase in maximum EBFC power density (≈1.7µWcm(-2)) with similar open circuit voltage (0.27V) compared to native GOX when physically adsorbed onto paddle-shaped electrodes made up of electrospun polyacrylonitrile fibers coated with gold nanoparticles and multi-wall carbon nanotubes. The formation of electroactive enzyme-redox polymer conjugates using PBPE represents a powerful new tool for the improvement of mediated enzyme-based bioelectronics without the need for free redox mediators or anode/cathode compartmentalization. Copyright © 2016 The Authors. Published by Elsevier B.V. All rights reserved.

  1. Utilization of fly ash to improve the quality of the acid mine drainage generated by oxidation of a sulphide-rich mining waste: Column experiments

    Energy Technology Data Exchange (ETDEWEB)

    Perez-Lopez, R.; Nieto, J.M.; de Almodovar, G.R. [University of Huelva, Huelva (Spain). Dept. of Geology

    2007-04-15

    The production of Acid Mine Drainage (AMD) as a result of the oxidative dissolution of sulphides is one of the main pollution problems affecting natural watercourses in mining environments with sulphide-rich residues. In this work, the generation of AMD was prevented by means of the addition of fly ash to sulphide-rich residues in non-saturated column experiments. A column experiment filled with a pyrite-rich sludge with artificial irrigation leached acid drainages (pH approx. 2) containing high concentrations of sulphate, iron and other metals. However, non-saturated column experiments filled with pyritic-rich sludge and fly ash drained leachates characterized by alkaline pH (pH up to 10), low sulphate concentration, and lack of iron and other metals in solution. The pyrite oxidative dissolution at high pH, as a consequence of the leaching of fly ash, favours the metal precipitation inside the column (mainly iron), the coating of pyrite grains, and the attenuation of the oxidation process, resulting in a great improvement in the quality of the leachates.

  2. Fuel and Greenhouse Gas Emission Reduction Potentials by Appropriate Fuel Switching and Technology Improvement in the Canadian Electricity Generation Sector

    Directory of Open Access Journals (Sweden)

    Farshid Zabihian

    2010-01-01

    Full Text Available Problem statement: In recent years, Greenhouse Gas (GHG emissions and their potential effects on global climate change have been a worldwide concern. According to International Energy Agency (IEA, power generation contributes more than half of the global GHG emissions. Approach: Purpose of this study is to examine GHG emission reduction potentials in the Canadian electricity generation sector through fuel switching and adoption of advanced power generation systems. To achieve this objective, eight different scenarios were introduced. In the first scenario, existing power stations’ fuel was switched to natural gas. Existing power plants were replaced by Natural Gas Combined Cycle (NGCC, Integrated Gasification Combined Cycle (IGCC, Solid Oxide Fuel Cell (SOFC, hybrid SOFC and SOFC-IGCC hybrid power stations in scenario numbers 2 to 6, respectively. In last two scenarios, CO2 capture systems were installed in the existing power plants and in the second scenario, respectively. Results: The results showed that Canada’s GHG emissions can be reduced by 33, 59, 20, 64, 69, 29, 86 and 94% based on the first to eighth scenarios, respectively. On the other hand, the second scenario is the most practical and its technology has already matured and is available. In this scenario by replacing existing power plants by NGCC power plants, Canada can fulfill more than 25% of its 238,000 kt year-1 commitment of GHG emission reduction to the Kyoto Protocol. In addition, the GHG emission reduction potentials for each province and Canada as a whole were presented and compared. Based on the results, Alberta, Ontario and Saskatchewan are the biggest producers of GHG in Canada by emitting 49, 21 and 14% of Canada’s GHG emissions, respectively. Therefore, they have higher potential to reduce GHG emissions. The comparison of the results for different provinces revealed that based on efficiency of electricity generation and consumed fuel distribution; specific scenario

  3. Optimal Placement and Sizing of Distributed Generation And Capacitor Bank For Loss Reduction And Reliability Improvement In Distribution Systems

    Directory of Open Access Journals (Sweden)

    Reza Baghipourr

    2014-12-01

    Full Text Available In this paper optimum size and location of the capacitors and distributed generators (DGs are determined for reliability improvement and power loss reduction using genetic algorithm (GA. The main innovation of this paper is using both DG and Capacitor for the reliability improvement and power loss reduction. For this purpose an objective function consisting of reliability cost, power loss cost and also DG's and capacitor's investment cost are considered. The effectiveness of the proposed method is examined in the 10 and 33 bus test systems and comparative studies are conducted before and after DG and Capacitor installation in the test systems. The results obtained show the effectiveness of the proposed method.

  4. Fault-tolerant control for current sensors of doubly fed induction generators based on an improved fault detection method

    DEFF Research Database (Denmark)

    Li, Hui; Yang, Chao; Hu, Yaogang

    2014-01-01

    Fault-tolerant control of current sensors is studied in this paper to improve the reliability of a doubly fed induction generator (DFIG). A fault-tolerant control system of current sensors is presented for the DFIG, which consists of a new current observer and an improved current sensor fault...... detection algorithm, and fault-tolerant control system are investigated by simulation. The results indicate that the outputs of the observer and the sensor are highly coherent. The fault detection algorithm can efficiently detect both soft and hard faults in current sensors, and the fault-tolerant control...... system can effectively tolerate both types of faults. © 2013 Published by Elsevier Ltd. All rights reserved....

  5. Performance calculation and improved model research of direct——drive permanent magnet generator based on FEM

    Institute of Scientific and Technical Information of China (English)

    ZHANG Jian; LI HeMing; LUO YingLi; DOU Na; CUI XueShen

    2012-01-01

    In some control strategies of the direct-rive permanent magnet generator (DDPMG),the mathematics model is excessively simplified and some complex nonlinear characteristics,such as core saturation and cross-saturation,are generally neglected.To solve this problem,this paper utilizes the frozen element permeability method to compute the armature self-and mutual-inductance,permanent magnet d-and q-axis flux varying with d-axis and q-axis current,then an improved model is presented in which the core saturation and cross-saturation between d-axis and q-axis are considered effectively.Based on this model,the method for computing the performance of the generators is also proposed.Taking a 1.5-MW DDPMG as an example,the time-stepping finite element method (T-S FEM) is adopted to analyze the performance with no-load and loaded conditions,the results show a good agreement with the ones obtained by the improved model.Compared with the simplified model,it is demonstrated that the presented model has the high efficiency and reliability and can provide a good reference for optimization design of DDPMG and other PM motors.

  6. Label-free fluorescence lifetime and second harmonic generation imaging microscopy improves quantification of experimental renal fibrosis.

    Science.gov (United States)

    Ranjit, Suman; Dobrinskikh, Evgenia; Montford, John; Dvornikov, Alexander; Lehman, Allison; Orlicky, David J; Nemenoff, Raphael; Gratton, Enrico; Levi, Moshe; Furgeson, Seth

    2016-11-01

    All forms of progressive renal diseases develop a final pathway of tubulointerstitial fibrosis and glomerulosclerosis. Renal fibrosis is usually quantified using histological staining, a process that is time-consuming and pathologist dependent. Here we develop a fast and operator-independent method to measure fibrosis utilizing the murine unilateral ureteral obstruction model which manifests a time-dependent fibrotic increase in obstructed kidneys while the contralateral kidneys are used as controls. After ureteral obstruction, kidneys were analyzed at 7, 14, and 21 days. Fibrosis was quantified using fluorescence lifetime imaging (FLIM) and second harmonic generation (SHG) in a Deep Imaging via Enhanced photon Recovery deep tissue imaging microscope. This microscope was developed for deep tissue along with second and third harmonic generation imaging and has extraordinary sensitivity toward harmonic generation. SHG data suggest the presence of more fibrillar collagen in the obstructed kidneys. The combination of short-wavelength FLIM and SHG analysis results in a robust assessment procedure independent of observer interpretation and let us create criteria to quantify the extent of fibrosis directly from the image. Thus, the FLIM-SHG technique shows remarkable improvement in quantification of renal fibrosis compared to standard histological techniques. Copyright © 2016 International Society of Nephrology. Published by Elsevier Inc. All rights reserved.

  7. Anode modification with formic acid: A simple and effective method to improve the power generation of microbial fuel cells

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Weifeng; Cheng, Shaoan, E-mail: shaoancheng@zju.edu.cn; Guo, Jian

    2014-11-30

    Highlights: • Carbon cloth anode is modified with formic acid by a simple and reliable approach. • The modification significantly enhances the power output of microbial fuel cells. • The modified anode surface favors the bacterial attachment and growth on anode. • The electron transfer rate of anode is promoted. - Abstract: The physicochemical properties of anode material directly affect the anodic biofilm formation and electron transfer, thus are critical for the power generation of microbial fuel cells (MFCs). In this work, carbon cloth anode was modified with formic acid to enhance the power production of MFCs. Formic acid modification of anode increased the maximum power density of a single-chamber air-cathode MFC by 38.1% (from 611.5 ± 6 mW/m{sup 2} to 877.9 ± 5 mW/m{sup 2}). The modification generated a cleaner electrode surface and a reduced content of oxygen and nitrogen groups on the anode. The surface changes facilitated bacterial growth on the anode and resulted in an optimized microbial community. Thus, the electron transfer rate on the modified anodes was enhanced remarkably, contributing to a higher power output of MFCs. Anode modification with formic acid could be an effective and simple method for improving the power generation of MFCs. The modification method holds a huge potential for large scale applications and is valuable for the scale-up and commercialization of microbial fuel cells.

  8. A new process to improve short-chain fatty acids and bio-methane generation from waste activated sludge.

    Science.gov (United States)

    Dong, Bin; Gao, Peng; Zhang, Dong; Chen, Yinguang; Dai, Lingling; Dai, Xiaohu

    2016-05-01

    As an important intermediate product, short-chain fatty acids (SCFAs) can be generated after hydrolysis and acidification from waste activated sludge, and then can be transformed to methane during anaerobic digestion process. In order to obtain more SCFA and methane, most studies in literatures were centered on enhancing the hydrolysis of sludge anaerobic digestion which was proved as un-efficient. Though the alkaline pretreatment in our previous study increased both the hydrolysis and acidification processes, it had a vast chemical cost which was considered uneconomical. In this paper, a low energy consumption pretreatment method, i.e. enhanced the whole three stages of the anaerobic fermentation processes at the same time, was reported, by which hydrolysis and acidification were both enhanced, and the SCFA and methane generation can be significantly improved with a small quantity of chemical input. Firstly, the effect of different pretreated temperatures and pretreatment time on sludge hydrolyzation was compared. It was found that sludge pretreated at 100°C for 60min can achieve the maximal hydrolyzation. Further, effects of different initial pHs on acidification of the thermal pretreated sludge were investigated and the highest SCFA was observed at initial pH9.0 with fermentation time of 6d, the production of which was 348.63mg COD/gVSS (6.8 times higher than the blank test) and the acetic acid was dominant acid. Then, the mechanisms for this new pretreatment significantly improving SCFA production were discussed. Finally, the effect of this low energy consumption pretreatment on methane generation was investigated.

  9. Improving the analytical performance of hydride generation non-dispersive atomic fluorescence spectrometry. Combined effect of additives and optical filters

    Science.gov (United States)

    D'Ulivo, Alessandro; Bramanti, Emilia; Lampugnani, Leonardo; Zamboni, Roberto

    2001-10-01

    The effects of tetrahydroborate and acid concentration and the presence of L-cysteine and thiourea were investigated in the determination of As, Bi and Sn using continuous flow hydride generation atomic fluorescence spectrometry (HG AFS). The aim was to find conditions allowing the control of those effects exerting negative influence on the analytical performance of the HG AFS apparatus. The effects taken into account were: (i) the radiation scattering generated by carryover of solution from the gas-liquid separator to the atomizer; (ii) the introduction of molecular species generated by tetrahydroborate decomposition into the atomizer; and (iii) interference effects arising from other elements in the sample matrix and from different acids. The effects (i) and (ii) could be controlled using mild reaction conditions in the HG stage. The effect of HG conditions on carryover was studied by radiation scattering experiments without hydride atomization. Compromised HG conditions were found by studying the effects of tetrahydroborate (0.1-20 g l -1) and acid (0.01-7 mol l -1) concentration, and the addition of L-cysteine (10 g l -1) and thiourea (0.1 mol l -1) on the HG AFS signals. The effect of optical filters was investigated with the aim of improving the signal-to-noise ratio. Optical filters with peak wavelengths of 190 and 220 nm provided an improvement of detection limits by factors of approximately 4 and 2 for As and Te, respectively. Under optimized conditions the detection limits were 6, 5, 3, 2, 2 and 9 ng l -1 for As, Sb, Bi, Sn, Se and Te, respectively. Good tolerance to various acid compositions and sample matrices was obtained by using L-cysteine or thiourea as masking agents. Determination of arsenic in sediment and copper certified reference materials, and of bismuth in steel, sediment, soil and ore certified reference material is reported.

  10. Optimization of Fin Distribution to Improve the Temperature Uniformity of a Heat Exchanger in a Thermoelectric Generator

    Science.gov (United States)

    Wang, Yiping; Wu, Cheng; Tang, Zebo; Yang, Xue; Deng, Yadong; Su, Chuqi

    2015-06-01

    Thermoelectric generators (TEGs) are currently a topic of interest for energy recovery in vehicles. By applying TEGs to the outside surface of the exhaust tailpipe, a small amount of electrical power can be generated because of the temperature difference between the hot exhaust gases and the automobile coolant. The amount of power is anticipated to be a few hundred watts based on the expected temperature difference and the properties of the thermoelectric materials used in TEGs. It is well know that, for thermoelectric exhaust energy recovery, the temperature uniformity of the heat exchangers has a strong influence on the electric power generation. In the current research, the temperature uniformity of a heat exchanger was improved by optimizing the fin distribution to maximize the electric power generated for a given vehicle TEG. A computational fluid dynamics (CFD) model of the heat exchanger was constructed to assess the influence of different fin distributions on the temperature uniformity and the pressure drop in the exhaust system. For the fin distributions, four factors were considered: the length of, spacing between, angle of, and thickness of the fins. Based on these four factors, a design of experiments study using the orthogonal experimental method was conducted to analyze the sensitivity to the design variables and build a database to set up a surrogate model using the Kriging response surface method. A multi-island genetic algorithm was used to optimize the fin distribution based on this surrogate model. To validate the accuracy of the CFD model, a generic heat exchanger module was manufactured and a related testbed constructed, then the temperature distribution on the surface of the exchanger was measured to compare with the results obtained by CFD.

  11. Sigma7500: an improved DUV laser pattern generator addressing sub-100-nm photomask accuracy and productivity requirements

    Science.gov (United States)

    Sjöberg, Henrik; Karlin, Tord; Rosling, Mats; Öström, Thomas; Måhlén, Jonas; Newman, Tom

    2006-05-01

    As photomask pattern complexity continues to increase, it becomes more challenging to control write times of shaped e-beam tools. This raises the related concerns of increased mask costs and extended mask cycle times. A strategy for sub-100 nm technology nodes is to use high-speed DUV laser pattern generators for as many layers as possible, reserving e-beam tools for only the most critical layers. With 248 nm optics and high-NA partially coherent imaging, the Sigma7500 increases the application space available to laser pattern generators. Image profiles are steepened with phase shifting methods, and pattern fidelity is improved with on-line corner enhancement. In the Sigma architecture, mask patterns are imaged with full fidelity and addressability in each writing pass. Because of this, the Sigma7500 provides additional means to improve write time by reducing the number of exposure passes. Platform improvements have resulted in a 2-pass writing accuracy that meets the 4-pass specification of the previous system. Write time is typically under two hours in 2-pass mode, compared to approximately three hours for 4-pass. The Sigma7500 can generally be used for all binary mask layers at the 90 nm technology node, and for about half the layers at 45 nm. The ProcessEqualizer TM function addresses long range CD errors arising from mask process effects. Mask data is sized in real time to compensate for process errors related to local pattern density, and also to correct for static process CD signatures. With a through-the-lens alignment system and both grid matching and pattern matching capabilities, the tool is also suited to 2 nd layer patterning for advanced phase shifting mask (PSM) applications down to 45 nm, with extendibility to 32 nm. Process integration is facilitated by the use of standard FEP-171 chemically amplified resist (CAR).

  12. Great Lakes Bathymetry

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Bathymetry of Lakes Michigan, Erie, Saint Clair, Ontario and Huron has been compiled as a component of a NOAA project to rescue Great Lakes lake floor geological and...

  13. Great Indoors Awards 2007

    Index Scriptorium Estoniae

    2007-01-01

    Hollandis Maastrichtis jagati 17. XI esimest korda rahvusvahelist auhinda The Great Indoors Award. Aasta sisekujundusfirmaks valiti Masamichi Katayama asutatud Wonderwall. Auhinna said veel Zaha Hadid, Heatherwick Studio, Ryui Nakamura Architects ja Item Idem

  14. Recurrence Statistics of Great Earthquakes

    CERN Document Server

    Ben-Naim, E; Johnson, P A

    2013-01-01

    We investigate the sequence of great earthquakes over the past century. To examine whether the earthquake record includes temporal clustering, we identify aftershocks and remove those from the record. We focus on the recurrence time, defined as the time between two consecutive earthquakes. We study the variance in the recurrence time and the maximal recurrence time. Using these quantities, we compare the earthquake record with sequences of random events, generated by numerical simulations, while systematically varying the minimal earthquake magnitude Mmin. Our analysis shows that the earthquake record is consistent with a random process for magnitude thresholds 7.0<=Mmin<=8.3, where the number of events is larger. Interestingly, the earthquake record deviates from a random process at magnitude threshold 8.4<=Mmin<= 8.5, where the number of events is smaller; however, this deviation is not strong enough to conclude that great earthquakes are clustered. Overall, the findings are robust both qualitat...

  15. An Improved Path-Generating Regulator for Two-Wheeled Robots to Track the Circle/Arc Passage

    Directory of Open Access Journals (Sweden)

    Jun Dai

    2014-01-01

    Full Text Available The improved path-generating regulator (PGR is proposed to path track the circle/arc passage for two-wheeled robots. The PGR, which is a control method for robots so as to orient its heading toward the tangential direction of one of the curves belonging to the family of path functions, is applied to navigation problem originally. Driving environments for robots are usually roads, streets, paths, passages, and ridges. These tracks can be seen as they consist of straight lines and arcs. In the case of small interval, arc can be regarded as straight line approximately; therefore we extended the PGR to drive the robot move along circle/arc passage based on the theory that PGR to track the straight passage. In addition, the adjustable look-ahead method is proposed to improve the robot trajectory convergence property to the target circle/arc. The effectiveness is proved through MATLAB simulations on both the comparisons with the PGR and the improved PGR with adjustable look-ahead method. The results of numerical simulations show that the adjustable look-ahead method has better convergence property and stronger capacity of resisting disturbance.

  16. Next-generation sequencing approaches for improvement of lactic acid bacteria-fermented plant-based beverages

    Directory of Open Access Journals (Sweden)

    Jordyn Bergsveinson

    2017-01-01

    Full Text Available Plant-based beverages and milk alternatives produced from cereals and legumes have grown in popularity in recent years due to a range of consumer concerns over dairy products. These plant-based products can often have undesirable physiochemical properties related to flavour, texture, and nutrient availability and/or deficiencies. Lactic acid bacteria (LAB fermentation offers potential remediation for many of these issues, and allows consumers to retain their perception of the resultant products as natural and additive-free. Using next-generation sequencing (NGS or omics approaches to characterize LAB isolates to find those that will improve properties of plant-based beverages is the most direct way to product improvement. Although NGS/omics approaches have been extensively used for selection of LAB for use in the dairy industry, a comparable effort has not occurred for selecting LAB for fermenting plant raw substrates, save those used in producing wine and certain types of beer. Here we review the few and recent applications of NGS/omics to profile and improve LAB fermentation of various plant-based substrates for beverage production. We also identify specific issues in the production of various LAB fermented plant-based beverages that such NGS/omics applications have the power to resolve.

  17. Great ape foresight is looking great.

    Science.gov (United States)

    Osvath, Mathias

    2010-09-01

    Suddendorf, Corballis and Collier-Baker (Anim Cogn 12: 751-754, 2009) comment on a study on great ape foresight (Osvath and Osvath, Anim Cogn 11: 661-674, 2008). That study consisted of four experiments investigating foresight in chimpanzees and orangutans, examining in particular whether the planning they exhibit is best explained by assuming an episodic cognitive system. This system has widely been regarded as exclusive to humans. Indeed, the Bischof-Köhler hypothesis explicitly states that planning for a future need is outside the abilities of non-humans. In our paper, we argued that the results implied the presence of episodic abilities and challenged the Bischof-Köhler hypothesis. Suddendorf et al. are not ready to accept this claim. They critique each experiment in detail and maintain their view that episodic cognition is unique to humans. Here, I point out the misapprehensions and weaknesses in their critique notably a lack of appreciation for how the experiments in the study are interrelated and serve as controls for each other and for the baseline experiment. I reinforce my earlier conclusions with a number of recently published findings.

  18. Improving Photometric Redshifts using GALEX Observations for the SDSS Stripe 82 and the Next Generation of SZ Cluster Surveys

    CERN Document Server

    Niemack, Michael D; Verde, Licia; Menanteau, Felipe; Panter, Ben; Spergel, David

    2008-01-01

    Four large-area Sunyaev-Zeldovich (SZ) experiments -- APEX-SZ, SPT, ACT, and Planck -- promise to detect clusters of galaxies through the distortion of Cosmic Microwave Background photons by hot (> 10^6 K) cluster gas (the SZ effect) over thousands of square degrees. A large observational follow-up effort to obtain redshifts for these SZ-detected clusters is under way. Given the large area covered by these surveys, most of the redshifts will be obtained via the photometric redshift (photo-z) technique. Here we demonstrate, in an application using ~3000 SDSS stripe 82 galaxies with r<20, how the addition of GALEX photometry (FUV, NUV) greatly improves the photometric redshifts of galaxies obtained with optical griz or ugriz photometry. In the case where large spectroscopic training sets are available, empirical neural-network-based techniques (e.g., ANNz) can yield a photo-z scatter of $\\sigma_z = 0.018 (1+z)$. If large spectroscopic training sets are not available, the addition of GALEX data makes possible...

  19. Identification and Characterization of BMS-955176, a Second-Generation HIV-1 Maturation Inhibitor with Improved Potency, Antiviral Spectrum, and Gag Polymorphic Coverage.

    Science.gov (United States)

    Nowicka-Sans, Beata; Protack, Tricia; Lin, Zeyu; Li, Zhufang; Zhang, Sharon; Sun, Yongnian; Samanta, Himadri; Terry, Brian; Liu, Zheng; Chen, Yan; Sin, Ny; Sit, Sing-Yuen; Swidorski, Jacob J; Chen, Jie; Venables, Brian L; Healy, Matthew; Meanwell, Nicholas A; Cockett, Mark; Hanumegowda, Umesh; Regueiro-Ren, Alicia; Krystal, Mark; Dicker, Ira B

    2016-07-01

    activity and a greatly improved preclinical profile compared to that of bevirimat. Copyright © 2016 Nowicka-Sans et al.

  20. Improved generation of rat gene knockouts by target-selected mutagenesis in mismatch repair-deficient animals

    Directory of Open Access Journals (Sweden)

    van Roekel Henk S

    2008-10-01

    Full Text Available Abstract Background The laboratory rat (Rattus norvegicus is one of the preferred model organisms in physiological and pharmacological research, although the availability of specific genetic models, especially gene knockouts, is limited. N-ethyl-N-nitrosourea (ENU-driven target-selected mutagenesis is currently the most successful method in rats, although it is still very laborious and expensive. Results As ENU-induced DNA damage is normally recognized by the mismatch repair (MMR system, we hypothesized that the effectiveness of the target-selected mutagenesis approach could be improved by using a MMR-deficient genetic background. Indeed, Msh6 knockout rats were found to be more sensitive to ENU treatment and the germ line mutation rate was boosted more than two-fold to 1 mutation per 585 kb. In addition, the molecular mutation spectrum was found to be changed in favor of generating knockout-type alleles by ~20%, resulting in an overall increase in efficiency of ~2.5 fold. The improved effectiveness was demonstrated by high throughput mutation discovery in 70 Mb of sequence in a set of only 310 mutant F1 rats. This resulted in the identification of 89 mutations of which four introduced a premature stopcodon and 64 resulted in amino acid changes. Conclusion Taken together, we show that the use of a MMR-deficient background considerably improves ENU-driven target-selected mutagenesis in the rat, thereby reducing animal use as well as screening costs. The use of a mismatch repair-deficient genetic background for improving mutagenesis and target-selected knockout efficiency is in principle applicable to any organism of interest.

  1. Improved generation of rat gene knockouts by target-selected mutagenesis in mismatch repair-deficient animals

    Science.gov (United States)

    van Boxtel, Ruben; Toonen, Pim W; Verheul, Mark; van Roekel, Henk S; Nijman, Isaac J; Guryev, Victor; Cuppen, Edwin

    2008-01-01

    Background The laboratory rat (Rattus norvegicus) is one of the preferred model organisms in physiological and pharmacological research, although the availability of specific genetic models, especially gene knockouts, is limited. N-ethyl-N-nitrosourea (ENU)-driven target-selected mutagenesis is currently the most successful method in rats, although it is still very laborious and expensive. Results As ENU-induced DNA damage is normally recognized by the mismatch repair (MMR) system, we hypothesized that the effectiveness of the target-selected mutagenesis approach could be improved by using a MMR-deficient genetic background. Indeed, Msh6 knockout rats were found to be more sensitive to ENU treatment and the germ line mutation rate was boosted more than two-fold to 1 mutation per 585 kb. In addition, the molecular mutation spectrum was found to be changed in favor of generating knockout-type alleles by ~20%, resulting in an overall increase in efficiency of ~2.5 fold. The improved effectiveness was demonstrated by high throughput mutation discovery in 70 Mb of sequence in a set of only 310 mutant F1 rats. This resulted in the identification of 89 mutations of which four introduced a premature stopcodon and 64 resulted in amino acid changes. Conclusion Taken together, we show that the use of a MMR-deficient background considerably improves ENU-driven target-selected mutagenesis in the rat, thereby reducing animal use as well as screening costs. The use of a mismatch repair-deficient genetic background for improving mutagenesis and target-selected knockout efficiency is in principle applicable to any organism of interest. PMID:18840264

  2. Internal friction between fluid particles of MHD tangent hyperbolic fluid with heat generation: Using coefficients improved by Cash and Karp

    Science.gov (United States)

    Salahuddin, T.; Khan, Imad; Malik, M. Y.; Khan, Mair; Hussain, Arif; Awais, Muhammad

    2017-05-01

    The present work examines the internal resistance between fluid particles of tangent hyperbolic fluid flow due to a non-linear stretching sheet with heat generation. Using similarity transformations, the governing system of partial differential equations is transformed into a coupled non-linear ordinary differential system with variable coefficients. Unlike the current analytical works on the flow problems in the literature, the main concern here is to numerically work out and find the solution by using Runge-Kutta-Fehlberg coefficients improved by Cash and Karp (Naseer et al., Alexandria Eng. J. 53, 747 (2014)). To determine the relevant physical features of numerous mechanisms acting on the deliberated problem, it is sufficient to have the velocity profile and temperature field and also the drag force and heat transfer rate all as given in the current paper.

  3. An Improved Control Strategy of Limiting the DC-Link Voltage Fluctuation for a Doubly Fed Induction Wind Generator

    DEFF Research Database (Denmark)

    Yao, J.; Li, H.; Liao, Y.;

    2008-01-01

    The paper presents to develop a new control strategy of limiting the dc-link voltage fluctuation for a back-to-back pulsewidth modulation converter in a doubly fed induction generator (DFIG) for wind turbine systems. The reasons of dc-link voltage fluctuation are analyzed. An improved control...... strategy with the instantaneous rotor power feedback is proposed to limit the fluctuation range of the dc-link voltage. An experimental rig is set up to valid the proposed strategy, and the dynamic performances of the DFIG are compared with the traditional control method under a constant grid voltage....... Furthermore, the capabilities of keeping the dc-link voltage stable are also compared in the ride-through control of DFIG during a three-phase grid fault, by using a developed 2 MW DFIG wind power system model. Both the experimental and simulation results have shown that the proposed control strategy is more...

  4. Efficient generation of marker-free transgenic rice plants using an improved transposon-mediated transgene reintegration strategy.

    Science.gov (United States)

    Gao, Xiaoqing; Zhou, Jie; Li, Jun; Zou, Xiaowei; Zhao, Jianhua; Li, Qingliang; Xia, Ran; Yang, Ruifang; Wang, Dekai; Zuo, Zhaoxue; Tu, Jumin; Tao, Yuezhi; Chen, Xiaoyun; Xie, Qi; Zhu, Zengrong; Qu, Shaohong

    2015-01-01

    Marker-free transgenic plants can be developed through transposon-mediated transgene reintegration, which allows intact transgene insertion with defined boundaries and requires only a few primary transformants. In this study, we improved the selection strategy and validated that the maize (Zea mays) Activator/Dissociation (Ds) transposable element can be routinely used to generate marker-free transgenic plants. A Ds-based gene of interest was linked to green fluorescent protein in transfer DNA (T-DNA), and a green fluorescent protein-aided counterselection against T-DNA was used together with polymerase chain reaction (PCR)-based positive selection for the gene of interest to screen marker-free progeny. To test the efficacy of this strategy, we cloned the Bacillus thuringiensis (Bt) δ-endotoxin gene into the Ds elements and transformed transposon vectors into rice (Oryza sativa) cultivars via Agrobacterium tumefaciens. PCR assays of the transposon empty donor site exhibited transposition in somatic cells in 60.5% to 100% of the rice transformants. Marker-free (T-DNA-free) transgenic rice plants derived from unlinked germinal transposition were obtained from the T1 generation of 26.1% of the primary transformants. Individual marker-free transgenic rice lines were subjected to thermal asymmetric interlaced-PCR to determine Ds(Bt) reintegration positions, reverse transcription-PCR and enzyme-linked immunosorbent assay to detect Bt expression levels, and bioassays to confirm resistance against the striped stem borer Chilo suppressalis. Overall, we efficiently generated marker-free transgenic plants with optimized transgene insertion and expression. The transposon-mediated marker-free platform established in this study can be used in rice and possibly in other important crops.

  5. Improved optical limiting performance of laser-ablation-generated metal nanoparticles due to silica-microsphere-induced local field enhancement.

    Science.gov (United States)

    Du, Zheren; Chen, Lianwei; Kao, Tsung-Sheng; Wu, Mengxue; Hong, Minghui

    2015-01-01

    For practical application, optical limiting materials must exhibit a fast response and a low threshold in order to be used for the protection of the human eye and electro-optical sensors against intense light. Many nanomaterials have been found to exhibit optical limiting properties. Laser ablation offers the possibility of fabricating nanoparticles from a wide range of target materials. For practical use of these materials, their optical limiting performance, including optical limiting threshold and the ability to efficiently attenuate high intensity light, needs to be improved. In this paper, we fabricate nanoparticles of different metals by laser ablation in liquid. We study the optical nonlinear properties of the laser-generated nanoparticle dispersion. Silica microspheres are used to enhance the optical limiting performance of the nanoparticle dispersion. The change in the optical nonlinear properties of the laser-generated nanoparticle dispersion caused by silica microspheres is studied. It is found that the incident laser beam is locally focused by the microspheres, leading to an increased optical nonlinearity of the nanoparticle dispersion.

  6. Improved optical limiting performance of laser-ablation-generated metal nanoparticles due to silica-microsphere-induced local field enhancement

    Directory of Open Access Journals (Sweden)

    Zheren Du

    2015-05-01

    Full Text Available For practical application, optical limiting materials must exhibit a fast response and a low threshold in order to be used for the protection of the human eye and electro-optical sensors against intense light. Many nanomaterials have been found to exhibit optical limiting properties. Laser ablation offers the possibility of fabricating nanoparticles from a wide range of target materials. For practical use of these materials, their optical limiting performance, including optical limiting threshold and the ability to efficiently attenuate high intensity light, needs to be improved. In this paper, we fabricate nanoparticles of different metals by laser ablation in liquid. We study the optical nonlinear properties of the laser-generated nanoparticle dispersion. Silica microspheres are used to enhance the optical limiting performance of the nanoparticle dispersion. The change in the optical nonlinear properties of the laser-generated nanoparticle dispersion caused by silica microspheres is studied. It is found that the incident laser beam is locally focused by the microspheres, leading to an increased optical nonlinearity of the nanoparticle dispersion.

  7. Automated Gel Size Selection to Improve the Quality of Next-generation Sequencing Libraries Prepared from Environmental Water Samples.

    Science.gov (United States)

    Uyaguari-Diaz, Miguel I; Slobodan, Jared R; Nesbitt, Matthew J; Croxen, Matthew A; Isaac-Renton, Judith; Prystajecky, Natalie A; Tang, Patrick

    2015-04-17

    Next-generation sequencing of environmental samples can be challenging because of the variable DNA quantity and quality in these samples. High quality DNA libraries are needed for optimal results from next-generation sequencing. Environmental samples such as water may have low quality and quantities of DNA as well as contaminants that co-precipitate with DNA. The mechanical and enzymatic processes involved in extraction and library preparation may further damage the DNA. Gel size selection enables purification and recovery of DNA fragments of a defined size for sequencing applications. Nevertheless, this task is one of the most time-consuming steps in the DNA library preparation workflow. The protocol described here enables complete automation of agarose gel loading, electrophoretic analysis, and recovery of targeted DNA fragments. In this study, we describe a high-throughput approach to prepare high quality DNA libraries from freshwater samples that can be applied also to other environmental samples. We used an indirect approach to concentrate bacterial cells from environmental freshwater samples; DNA was extracted using a commercially available DNA extraction kit, and DNA libraries were prepared using a commercial transposon-based protocol. DNA fragments of 500 to 800 bp were gel size selected using Ranger Technology, an automated electrophoresis workstation. Sequencing of the size-selected DNA libraries demonstrated significant improvements to read length and quality of the sequencing reads.

  8. Cave Dwellers’ Lives Improved

    Institute of Scientific and Technical Information of China (English)

    1994-01-01

    IN the Loess Plateau of northern Shaanxi. there are many gullies but little rain, which has deeply affected the growth of crops there. People have been living under hard conditions for generations until very recently. The State government has encouraged rural economic policies which has enabled the people of this area to develop a diversified economy that has greatly improved life.

  9. Great Zimbabwe's water

    DEFF Research Database (Denmark)

    Pikirayi, Innocent; Sulas, Federica; Musindo, Tendai Treddah

    2016-01-01

    in the region's well-watered granite hills and valleys, and culminating in a vast urban and trading society. Later, c.1550 AD, it is argued, drying climate, land overexploitation, and changing regional trading patterns would lead to the decline of Great Zimbabwe. A review of this model is necessary since Great...... Zimbabwe and communities living around it survive in a region constantly threatened by water crises. However, we still know very little on the forms and uses of water and how these have influenced its development and demise. This article offers a multilayered review of available information on water......, including new records on environmental sequences, modern water sources, and provisioning models from in and around Great Zimbabwe. The integration of both old and new datasets allows us to follow the history of people-water interaction from early times to the present. We argue that understanding...

  10. Generation of novel AAV variants by directed evolution for improved CFTR delivery to human ciliated airway epithelium.

    Science.gov (United States)

    Li, Wuping; Zhang, Liqun; Johnson, Jarrod S; Zhijian, Wu; Grieger, Joshua C; Ping-Jie, Xiao; Drouin, Lauren M; Agbandje-McKenna, Mavis; Pickles, Raymond J; Samulski, R Jude

    2009-12-01

    Recombinant adeno-associated virus (AAV) vectors expressing the cystic fibrosis transmembrane conductance regulator (CFTR) gene have been used to deliver CFTR to the airway epithelium of cystic fibrosis (CF) patients. However, no significant CFTR function has been demonstrated likely due to low transduction efficiencies of the AAV vectors. To improve AAV transduction efficiency for human airway epithelium (HAE), we generated a chimeric AAV library and performed directed evolution of AAV on an in vitro model of human ciliated airway epithelium. Two independent and novel AAV variants were identified that contained capsid components from AAV-1, AAV-6, and/or AAV-9. The transduction efficiencies of the two novel AAV variants for human ciliated airway epithelium were three times higher than that for AAV-6. The novel variants were then used to deliver CFTR to ciliated airway epithelium from CF patients. Here we show that our novel AAV variants, but not the parental, AAV provide sufficient CFTR delivery to correct the chloride ion transport defect to ~25% levels measured in non-CF cells. These results suggest that directed evolution of AAV on relevant in vitro models will enable further improvements in CFTR gene transfer efficiency and the development of an efficacious and safe gene transfer vector for CF lung disease.

  11. Generation of Novel AAV Variants by Directed Evolution for Improved CFTR Delivery to Human Ciliated Airway Epithelium

    Science.gov (United States)

    Li, Wuping; Zhang, Liqun; Johnson, Jarrod S; Zhijian, Wu; Grieger, Joshua C; Ping-Jie, Xiao; Drouin, Lauren M; Agbandje-McKenna, Mavis; Pickles, Raymond J; Samulski, R Jude

    2009-01-01

    Recombinant adeno-associated virus (AAV) vectors expressing the cystic fibrosis transmembrane conductance regulator (CFTR) gene have been used to deliver CFTR to the airway epithelium of cystic fibrosis (CF) patients. However, no significant CFTR function has been demonstrated likely due to low transduction efficiencies of the AAV vectors. To improve AAV transduction efficiency for human airway epithelium (HAE), we generated a chimeric AAV library and performed directed evolution of AAV on an in vitro model of human ciliated airway epithelium. Two independent and novel AAV variants were identified that contained capsid components from AAV-1, AAV-6, and/or AAV-9. The transduction efficiencies of the two novel AAV variants for human ciliated airway epithelium were three times higher than that for AAV-6. The novel variants were then used to deliver CFTR to ciliated airway epithelium from CF patients. Here we show that our novel AAV variants, but not the parental, AAV provide sufficient CFTR delivery to correct the chloride ion transport defect to ~25% levels measured in non-CF cells. These results suggest that directed evolution of AAV on relevant in vitro models will enable further improvements in CFTR gene transfer efficiency and the development of an efficacious and safe gene transfer vector for CF lung disease. PMID:19603002

  12. Great Expectations. [Lesson Plan].

    Science.gov (United States)

    Devine, Kelley

    Based on Charles Dickens' novel "Great Expectations," this lesson plan presents activities designed to help students understand the differences between totalitarianism and democracy; and a that a writer of a story considers theme, plot, characters, setting, and point of view. The main activity of the lesson involves students working in groups to…

  13. The Great Dismal Swamp

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This introduction to the natural history of the Great Dismal Swamp is presented at a time when 50,000 acres of the Swamp are being converted from private holdings to...

  14. The Great Lakes.

    Science.gov (United States)

    Seasons, 1987

    1987-01-01

    The Great Lakes are one of the world's greatest reserviors of fresh water, the foundation of Ontario's economic development, a primary force in ecological systems, and a base for pleasure and recreation. These lakes and their relationship with people of Canada and the United States can be useful as a subject for teaching the impact of human…

  15. Great cities look small

    CERN Document Server

    Sim, Aaron; Barahona, Mauricio; Stumpf, Michael P H

    2015-01-01

    Great cities connect people; failed cities isolate people. Despite the fundamental importance of physical, face-to-face social-ties in the functioning of cities, these connectivity networks are not explicitly observed in their entirety. Attempts at estimating them often rely on unrealistic over-simplifications such as the assumption of spatial homogeneity. Here we propose a mathematical model of human interactions in terms of a local strategy of maximising the number of beneficial connections attainable under the constraint of limited individual travelling-time budgets. By incorporating census and openly-available online multi-modal transport data, we are able to characterise the connectivity of geometrically and topologically complex cities. Beyond providing a candidate measure of greatness, this model allows one to quantify and assess the impact of transport developments, population growth, and other infrastructure and demographic changes on a city. Supported by validations of GDP and HIV infection rates ac...

  16. Great Zimbabwe's water

    DEFF Research Database (Denmark)

    Pikirayi, Innocent; Sulas, Federica; Musindo, Tendai Treddah;

    2016-01-01

    , including new records on environmental sequences, modern water sources, and provisioning models from in and around Great Zimbabwe. The integration of both old and new datasets allows us to follow the history of people-water interaction from early times to the present. We argue that understanding......Once a thriving center with commercial links to the Indian Ocean, what remains of Great Zimbabwe is its monumental architecture. Its rise and decline have long been linked to environmental changes in southern Zimbabwe, beginning in the second half of the 13th century with agropastoralists thriving...... of the local environment was vital in managing both water excesses and shortages in the past, and show that some of this knowledge survives among indigenous communities linked to the site and living in the surrounding landscape. While nearby Masvingo town has persistently lived under water-emergency conditions...

  17. Not so Great Lakes?

    Science.gov (United States)

    Showstack, Randy

    In 1965, Frank Sinatra won the Grammy Award for his album, "September of My Years;" "Early Bird," the first commercial communications satellite, was launched; and Dr. Martin Luther King, Jr. was arrested in Selma, Alabama, during demonstrations against voter-registration rules.The year 1965 was also the last time water levels in the U.S. Great Lakes were as low as they are now.

  18. 新一代的过程改进模型:CMMI%A Process Improvement Mode of Next Generation--CMMI

    Institute of Scientific and Technical Information of China (English)

    谢超; 马士龙; 林梦香

    2001-01-01

    CMMI is a new process improvement model that is being developed by SEI. It is the evolution of process improvement and it may be representative of next generation of process improvement model.This paper provides a brief overview of the history of CMM family,the need for integration of those models ,the status of the CMMI effort,and the different descriptions of CMMI.

  19. Computational investigation of the flow field contribution to improve electricity generation in granular activated carbon-assisted microbial fuel cells

    Science.gov (United States)

    Zhao, Lei; Li, Jian; Battaglia, Francine; He, Zhen

    2016-11-01

    Microbial fuel cells (MFCs) offer an alternative approach to treat wastewater with less energy input and direct electricity generation. To optimize MFC anodic performance, adding granular activated carbon (GAC) has been proved to be an effective way, most likely due to the enlarged electrode surface for biomass attachment and improved mixing of the flow field. The impact of a flow field on the current enhancement within a porous anode medium (e.g., GAC) has not been well understood before, and thus is investigated in this study by using mathematical modeling of the multi-order Butler-Volmer equation with computational fluid dynamics (CFD) techniques. By comparing three different CFD cases (without GAC, with GAC as a nonreactive porous medium, and with GAC as a reactive porous medium), it is demonstrated that adding GAC contributes to a uniform flow field and a total current enhancement of 17%, a factor that cannot be neglected in MFC design. However, in an actual MFC operation, this percentage could be even higher because of the microbial competition and energy loss issues within a porous medium. The results of the present study are expected to help with formulating strategies to optimize MFC with a better flow pattern design.

  20. High-intensity Interval Training Improves Mitochondrial Function and Suppresses Thrombin Generation in Platelets undergoing Hypoxic Stress.

    Science.gov (United States)

    Wu, Li-Hua; Chang, Shao-Chiang; Fu, Tieh-Cheng; Huang, Ching-Hui; Wang, Jong-Shyan

    2017-06-23

    This study elucidates how high-intensity interval training (HIT) and moderate-intensity continuous training (MCT) affect mitochondrial functionality and thrombin generation (TG) in platelets following hypoxic exercise (HE, 100 W under 12% O2 for 30 min). Forty-five healthy sedentary males were randomized to engage either HIT (3-minute intervals at 40% and 80%VO2max, n = 15) or MCT (sustained 60%VO2max, n = 15) for 30 minutes/day, 5 days/week for 6 weeks, or to a control group (CTL, n = 15) that did not received exercise intervention. Before the intervention, HE (i) reduced the ATP-linked O2 consumption rate (OCR), the reserve capacity of OCR, and the activities of citrate synthase (CS) and succinate dehydrogenase (SDH), (ii) lowered mitochondrial membrane potential (MP) and elevated matrix oxidant burden (MOB) in platelets, and (iii) enhanced dynamic TG in platelet-rich plasma (PRP), which responses were attenuated by pretreating PRP with oligomycin or rotenone/antimycin A. However, 6-week HIT (i) increased mitochondrial OCR capacity with enhancing the CS and SDH activities and (ii) heightened mitochondrial MP with depressing MOB in platelets following HE, compared to those of MCT and CTL. Moreover, the HIT suppressed the HE-promoted dynamic TG in PRP. Hence, we conclude that the HIT simultaneously improves mitochondrial bioenergetics and suppresses dynamic TG in platelets undergoing hypoxia.

  1. Pip6-PMO, A New Generation of Peptide-oligonucleotide Conjugates With Improved Cardiac Exon Skipping Activity for DMD Treatment.

    Science.gov (United States)

    Betts, Corinne; Saleh, Amer F; Arzumanov, Andrey A; Hammond, Suzan M; Godfrey, Caroline; Coursindel, Thibault; Gait, Michael J; Wood, Matthew Ja

    2012-08-14

    Antisense oligonucleotides (AOs) are currently the most promising therapeutic intervention for Duchenne muscular dystrophy (DMD). AOs modulate dystrophin pre-mRNA splicing, thereby specifically restoring the dystrophin reading frame and generating a truncated but semifunctional dystrophin protein. Challenges in the development of this approach are the relatively poor systemic AO delivery and inefficient dystrophin correction in affected non-skeletal muscle tissues, including the heart. We have previously reported impressive heart activity including high-splicing efficiency and dystrophin restoration following a single administration of an arginine-rich cell-penetrating peptide (CPPs) conjugated to a phosphorodiamidate morpholino oligonucleotide (PMO): Pip5e-PMO. However, the mechanisms underlying this activity are poorly understood. Here, we report studies involving single dose administration (12.5 mg/kg) of derivatives of Pip5e-PMO, consecutively assigned as Pip6-PMOs. These peptide-PMOs comprise alterations to the central hydrophobic core of the Pip5e peptide and illustrate that certain changes to the peptide sequence improves its activity; however, partial deletions within the hydrophobic core abolish its efficiency. Our data indicate that the hydrophobic core of the Pip sequences is critical for PMO delivery to the heart and that specific modifications to this region can enhance activity further. The results have implications for therapeutic PMO development for DMD.

  2. Pip6-PMO, A New Generation of Peptide-oligonucleotide Conjugates With Improved Cardiac Exon Skipping Activity for DMD Treatment

    Directory of Open Access Journals (Sweden)

    Corinne Betts

    2012-01-01

    Full Text Available Antisense oligonucleotides (AOs are currently the most promising therapeutic intervention for Duchenne muscular dystrophy (DMD. AOs modulate dystrophin pre-mRNA splicing, thereby specifically restoring the dystrophin reading frame and generating a truncated but semifunctional dystrophin protein. Challenges in the development of this approach are the relatively poor systemic AO delivery and inefficient dystrophin correction in affected non-skeletal muscle tissues, including the heart. We have previously reported impressive heart activity including high-splicing efficiency and dystrophin restoration following a single administration of an arginine-rich cell-penetrating peptide (CPPs conjugated to a phosphorodiamidate morpholino oligonucleotide (PMO: Pip5e-PMO. However, the mechanisms underlying this activity are poorly understood. Here, we report studies involving single dose administration (12.5 mg/kg of derivatives of Pip5e-PMO, consecutively assigned as Pip6-PMOs. These peptide-PMOs comprise alterations to the central hydrophobic core of the Pip5e peptide and illustrate that certain changes to the peptide sequence improves its activity; however, partial deletions within the hydrophobic core abolish its efficiency. Our data indicate that the hydrophobic core of the Pip sequences is critical for PMO delivery to the heart and that specific modifications to this region can enhance activity further. The results have implications for therapeutic PMO development for DMD.

  3. Integration of a Wind Turbine Based Doubly Fed Induction Generator Using STATCOM and CROWBAR for Transient Stability Improvement

    Directory of Open Access Journals (Sweden)

    Bhupendra kumar

    2015-07-01

    Full Text Available Wind power stations mostly placed in remote areas; so they are characterized by weak grids and are often submitted to power system disturbance like faults, voltage sag etc. In this paper the crowbar protection method is used to ride through voltage sags and STATCOM is used to quickly sense the voltage sag and overcome it. The behavior of these machines during grid failure is an important issue. DFIG consists of a common induction generator with slip ring and a partial scale power electronic converter. Indirect field oriented controller is applied to rotor side converter for active power control and voltage regulation of wind turbine. On grid side PQ control scheme is applied. Wind turbine and its control units are described in details and also for STATCOM control. All power system components are simulated in MATLAB/ SIMULINK software. For studying the performance of controller, different abnormal conditions are applied even the worst case. Simulation results prove that the performance of STATCOM and DFIG control schemes as improving power quality and stability of wind turbine.

  4. A Fuzzy Logic Control Strategy for Doubly Fed Induction Generator for Improved Performance under Faulty Operating Conditions

    Directory of Open Access Journals (Sweden)

    G. Venu Madhav

    2014-12-01

    Full Text Available In this paper, decouple PI control for output active and reactive powers which is the common control technique for power converter of Doubly Fed Induction Generator (DFIG is presented. But there are some disadvantages with this control method like uncertainty about the exact model, behavior of some parameters or unpredictable wind speed and tuning of PI parameters. To overcome the mentioned disadvantages a fuzzy logic control of DFIG wind turbine is presented and is compared with PI controller. To validate the proposed scheme, simulation results are presented, these results showed that the performance of fuzzy control of DFIG is excellent and it improves power quality and stability of wind turbine compared to PI controller. The Fuzzy logic controller is applied to rotor side converter for active power control and voltage regulation of wind turbine. The entire work is carried out in MATLab/Simulink. Different faulty operating conditions are considered to prove the effective implementation of the proposed control scheme.

  5. Plate-based diversity subset screening generation 2: an improved paradigm for high-throughput screening of large compound files.

    Science.gov (United States)

    Bell, Andrew S; Bradley, Joseph; Everett, Jeremy R; Loesel, Jens; McLoughlin, David; Mills, James; Peakman, Marie-Claire; Sharp, Robert E; Williams, Christine; Zhu, Hongyao

    2016-11-01

    High-throughput screening (HTS) is an effective method for lead and probe discovery that is widely used in industry and academia to identify novel chemical matter and to initiate the drug discovery process. However, HTS can be time consuming and costly and the use of subsets as an efficient alternative to screening entire compound collections has been investigated. Subsets may be selected on the basis of chemical diversity, molecular properties, biological activity diversity or biological target focus. Previously, we described a novel form of subset screening: plate-based diversity subset (PBDS) screening, in which the screening subset is constructed by plate selection (rather than individual compound cherry-picking), using algorithms that select for compound quality and chemical diversity on a plate basis. In this paper, we describe a second-generation approach to the construction of an updated subset: PBDS2, using both plate and individual compound selection, that has an improved coverage of the chemical space of the screening file, whilst only selecting the same number of plates for screening. We describe the validation of PBDS2 and its successful use in hit and lead discovery. PBDS2 screening became the default mode of singleton (one compound per well) HTS for lead discovery in Pfizer.

  6. The Use of Redundancy to Improve Reliability of Deep Space Missions Using Stirling Radioisotope Generator Power Sources

    Science.gov (United States)

    Bolotin, Gary; Everline, Chet; Schmitz, Paul; Distefano, Sal

    2014-01-01

    This study will look at the 140 We class generator as originally envisioned for the ASRG and a larger generator that is scaled up to use four times the fuel. The results discussed below quantify the effect of the use of smaller generators and indicates that a scheme that makes use of several smaller generators enhances the system reliability and allows for more graceful degradation.

  7. The Use of Redundancy to Improve Reliability of Deep Space Missions Using Stirling Radioisotope Generator Power Sources

    Science.gov (United States)

    Bolotin, Gary; Everline, Chet; Schmitz, Paul; Distefano, Sal

    2014-01-01

    This study will look at the 140 We class generator as originally envisioned for the ASRG and a larger generator that is scaled up to use four times the fuel. The results discussed below quantify the effect of the use of smaller generators and indicates that a scheme that makes use of several smaller generators enhances the system reliability and allows for more graceful degradation.

  8. Source Credibility and Idea Improvement Have Independent Effects on Unconscious Plagiarism Errors in Recall and Generate-New Tasks

    Science.gov (United States)

    Perfect, Timothy J.; Field, Ian; Jones, Robert

    2009-01-01

    Unconscious plagiarism occurs when people try to generate new ideas or when they try to recall their own ideas from among a set generated by a group. In this study, the factors that independently influence these two forms of plagiarism error were examined. Participants initially generated solutions to real-world problems in 2 domains of knowledge…

  9. Idiopathic great saphenous phlebosclerosis.

    Directory of Open Access Journals (Sweden)

    Ahmadreza Jodati

    2013-06-01

    Full Text Available Arterial sclerosis has been extensively described but reports on venous sclerosis are very sparse. Phlebosclerosis refers to the thickening and hardening of the venous wall. Despite its morphological similarities with arteriosclerosis and potential morbid consequences, phlebosclerosis has gained only little attention. We report a 72 year old male with paralysis and atrophy of the right leg due to childhood poliomyelitis who was referred for coronary artery bypass surgery. The great saphenous vein, harvested from the left leg, showed a hardened cord-like obliterated vein. Surprisingly, harvested veins from the atrophic limb were normal and successfully used for grafting.

  10. Synergetic merging of Cartosat-1 and RAMP to generate improved digital elevation model of Schirmacher oasis, east Antarctica

    Science.gov (United States)

    Jawak, S. D.; Luis, A. J.

    2014-11-01

    Available digital elevation models (DEMs) of Antarctic region generated by using radar altimetry and the Antarctic digital database (ADD) indicate elevation variations of up to hundreds of meters, which necessitates the generation of local DEM and its validation by using ground reference. An enhanced digital elevation model (eDEM) of the Schirmacher oasis region, east Antarctica, is generated synergistically by using Cartosat-1 stereo pair-derived photogrammetric DEM (CartoDEM)-based point elevation dataset and multitemporal radarsat Antarctic mapping project version 2 (RAMPv2) DEM-based point elevation dataset. In this study, we analyzed suite of interpolation techniques for constructing a DEM from RAMPv2 and CartoDEM-based point elevation datasets, in order to determine the level of confidence with which the interpolation techniques can generate a better interpolated continuous surface, and eventually improves the elevation accuracy of DEM from synergistically fused RAMPv2 and CartoDEM point elevation datasets. RAMPv2 points and CartoDEM points were used as primary data for various interpolation techniques such as ordinary kriging (OK), simple kriging (SK), universal kriging (UK), disjunctive kriging (DK) techniques, inverse distance weighted (IDW), global polynomial (GP) with power 1 and 2, local polynomial (LP) and radial basis functions (RBF). Cokriging of 2 variables with second dataset was used for ordinary cokriging (OCoK), simple cokriging (SCoK), universal cokriging (UCoK) and disjunctive cokriging (DCoK). The IDW, GP, LP, RBF, and kriging methods were applied to one variable, while Cokriging experiments were employed on two variables. The experiment of dataset and its combination produced two types of point elevation map categorized as (1) one variable (RAMPv2 Point maps and CartoDEM Point maps) and (2) two variables (RAMPv2 Point maps + CartoDEM Point maps). Interpolated surfaces were evaluated with the help of differential global positioning system

  11. Towards an Improved Understanding of the Signal Generated by an Underground Explosion:Case Study - Wookey Hole Caves, Somerset, UK

    Science.gov (United States)

    Taylor, J.; Butcher, A.; Kennett, K.; Horleston, A. C.

    2015-12-01

    In order to continue to improve our understanding of the dynamics of underground explosions, we analyse blast data from the recent expansion of the Wookey Hole cave system in Somerset, UK (July 2015). Such data has clear relevance and implication to the work of the Comprehensive Nuclear Test Ban Treaty Organization (CTBTO) and for verification of suspicious seismic events. We first analyse the pre- and post-blast seismic noise in order to characterize the resonant modes of the cave systems and identify any sources of persistent noise in the data. An unexpectedly high persistent noise source at 119.47Hz is thought to relate to electrical noise from machinery near to the recording site. With only a single three-component seismometer, ascertaining variations in the radiation patterns from the explosions was impossible. However by rotating the seismograms into their radial and transverse components, we were able to determine that both P- and S-waves were generated during the blasting. The source of these S-waves is under ongoing investigation, but scattering close to the source caused by the impedance contrast between the cavity and the surrounding bedrock, or fracturing of the bedrock during blasting, are both possibilities[1]. Frequency analysis on a sample of the data collected shows that for each blast, the dominant recorded frequency on the East component was around 35-40Hz for both the P- and S-arrivals. Dominant frequencies on the N and Z components was much more variable, up to 120Hz. For each blast, spectrograms show significant energy up to high frequencies across the duration of the recording, up to 125Hz, showing that little attenuation has occurred. [1] - Imhof, M. G., and M. N. Toksöz. "Scattering from tunnels near sources and their effect on seismic signatures of explosions." Bulletin of the Seismological Society of America 90.1 (2000): 229-242.

  12. Great Britain at CERN

    CERN Multimedia

    2006-01-01

    From 14 to 16 November 2006 Administration Building, Bldg. 60/61 - ground and 1st floor 09.30 - 17.30 Fifteen companies will present their latest technologies at the 'Great Britain at CERN' exhibition. British industry will exhibit products and technologies related to the field of particle physics. The main fields represented will be computing technologies, electrical engineering, electronics, mechanical engineering, vacuum & low temperature technologies and particle detectors. The exhibition is organised by BEAMA Exhibitions (the British Electrotechnical and Allied Manufacturers Association). Below you will find: a list of the exhibitors. A detailed programme will be available in due course: from your Departmental secretariat, from the Reception information desk, Building 33, at the exhibition itself. A detailed list of the companies is available at the following FI link: http://fi-dep.web.cern.ch/fi-dep/structure/memberstates/exhibitions_visits.htm LIST OF EXHIBITORS 3D Metrics Alma...

  13. Great Britain at CERN

    CERN Multimedia

    2006-01-01

    From 14 to 16 November 2006 Administration Building, Bldg. 60/61 - ground and 1st floor 09.30 - 17.30 Fifteen companies will present their latest technologies at the 'Great Britain at CERN' exhibition. British industry will exhibit products and technologies related to the field of particle physics. The main fields represented will be computing technologies, electrical engineering, electronics, mechanical engineering, vacuum & low temperature technologies and particle detectors. The exhibition is organised by BEAMA Exhibitions (the British Electrotechnical and Allied Manufacturers Association). Below you will find: a list of the exhibitors. A detailed programme will be available in due course: from your Departmental secretariat, from the Reception information desk, Building 33, at the exhibition itself. A detailed list of the companies is available at the following FI link: http://fi-dep.web.cern.ch/fi-dep/structure/memberstates/exhibitions_visits.htm LIST OF EXHIBITORS 3D Metrics Almat...

  14. The Great Scientists

    Science.gov (United States)

    Meadows, Jack

    1989-11-01

    This lively history of the development of science and its relationship to society combines vivid biographies of twelve pivotal scientists, commentary on the social and historical events of their time, and over four hundred illustrations, including many in color. The biographies span from classical times to the Atomic Age, covering Aristotle, Galileo, Harvey, Newton, Lavoisier, Humboldt, Faraday, Darwin, Pasteur, Curie, Freud, and Einstein. Through the biographies and a wealth of other material, the volume reveals how social forces have influenced the course of science. Along with the highly informative color illustrations, it contains much archival material never before published, ranging from medieval woodcuts, etchings from Renaissance anatomy texts, and pages from Harvey's journal, to modern false-color x-rays and infrared photographs of solar flares. A beautifully-designed, fact-filled, stimulating work, The Great Scientists will fascinate anyone with an interest in science and how history can influence scientific discovery.

  15. Improve the capability for waste heat power generation of cement kiln%如何提高水泥窑余热发电能力

    Institute of Scientific and Technical Information of China (English)

    蒋向辉

    2011-01-01

    通过分析研究余热电站的主要问题,采取技改措施提高机组的主参数,锅炉的旁通挡板改进,提高锅炉换热效率,加强发电系统与窑系统操作配合等提高水泥窑纯低温余热发电的能力。%Through the main problems in my company to take measures to improve the power output transformation of generating capacity of cement kiln 。1、Improve the main parameters of the generator;2、Improved boiler bypass valve;3、Improve the efficiency of the boiler

  16. The Last Great American Picture Show

    NARCIS (Netherlands)

    Elsaesser, Thomas; King, Noel; Horwath, Alexander

    2004-01-01

    The Last Great American Picture Show brings together essays by scholars and writers who chart the changing evaluations of the American cinema of the 1970s, sometimes referred to as the decade of the lost generation, but now more and more recognized as the first New Hollywood, without which the cinem

  17. Improvement of low speed induction generator performances and reducing the power of excitation and voltage control system

    Energy Technology Data Exchange (ETDEWEB)

    Budisan, N. [Politechnica Univ. of Timisoara (Romania); Hentea, T.; Mahil, S. [Purdue Univ. Calumet, Hammond, IN (United States); Madescu, G. [Romanian Academy, Timisoara (Romania)

    1996-12-31

    In this paper we present the results of our investigations concerning the utilization of induction generators at very low speed. It is shown that, by proper design, it is possible to obtain high efficiency and high power factor values. The optimized induction generators require lower reactive power resulting in lower size and price of the excitation control system. 4 refs., 2 figs.

  18. Speeding up the Development of China's Great TPI Industry%Speeding up the Development of China's Great TPI Industry

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    I. Expectation of Several Generations to Realize China's Great TPI Industry It is known from age to age that gutta percha tree is a particular traditional tree species of China with leaves, flowers, bark and fruits being used as medicine. The Chinese people have planted and applied gutta percha tree as medical care crude medicine for centuries due to its marvelous and well known function of improving the health.

  19. Remedial actions to improve the availability in steam generators; Acciones correctivas para mejorar la disponibilidad en generadores de vapor

    Energy Technology Data Exchange (ETDEWEB)

    Torres Toledano, J. Gerardo; Porras Loaiza, G. Lizbeth; Sanchez Hernandez, Laura E.; Salinas B, Victor M.; Nebart G, Jesus [Instituto de Investigaciones Electricas, Temixco, Morelos (Mexico)

    2001-07-01

    In this article the results of the analysis of recurrent faults of four Generating Units of Thermoelectric Power Plants (UGT) of the Commission Federal de Electricidad (CFE) are presented. In three of the four cases, the studies focused to identify and to correct the root causes of recurrent faults in steam generator tubes, the analyzed units are: U-2 of the Thermoelectric Complex Pdte. Adolfo Lopez Mateos (CTPALM) of Tuxpan, Veracruz; U-3 of the Salamanca Thermoelectric Power Plant (TPP), and U-1 and 2 of the Thermoelectric Power Plant (TPP) Felipe Carrillo Puerto of Valladolid, Yucatan. In the other case the combinations air insufficiency was analyzed as one of the causes of decrement of power of the Unit 1 of the TPP Gral. Manuel Alvarez Moreno of Manzanillo, Colima. The steam generators of Unit 2 of the CTPALM and Unit 3 of the TPP of Salamanca presented faults in the reheater (RH) bank. In this case the recommendations focused to the improvement in the operative conditions to attenuate the faults by corrosion at high temperature. Unlike the CTPALM, in the case of U-3 of Salamanca it was concluded that the redesign of the RH was necessary; for this purpose it was proposed to permute trajectories of hot tubes with the cold ones to make the steam temperature uniform at the RH outlet. In order to evaluate the problems that have appeared in the steam generator of Units 1 and 2 of the TPP Felipe Carrillo Puerto of Valladolid, Yucatan the faults of the tubes of water wall were analyzed and it was found that the main mechanism of overheat is due to the impact of the combustion flame. In the study of the Unit 1 of the TPP Gral. Manuel Alvarez Moreno of Manzanillo, Colima, a methodology was developed to quantify the contribution that the main equipment has in the decrement of the power of the unit; this methodology consists of applying a process of computational simulation based in the design conditions and of real operation. In agreement with the obtained results, it

  20. Remedial actions to improve the availability in steam generators; Acciones correctivas para mejorar la disponibilidad en generadores de vapor

    Energy Technology Data Exchange (ETDEWEB)

    Torres Toledano, J. Gerardo; Porras Loaiza, G. Lizbeth; Sanchez Hernandez, Laura E.; Salinas B, Victor M.; Nebart G, Jesus [Instituto de Investigaciones Electricas, Temixco, Morelos (Mexico)

    2001-07-01

    In this article the results of the analysis of recurrent faults of four Generating Units of Thermoelectric Power Plants (UGT) of the Commission Federal de Electricidad (CFE) are presented. In three of the four cases, the studies focused to identify and to correct the root causes of recurrent faults in steam generator tubes, the analyzed units are: U-2 of the Thermoelectric Complex Pdte. Adolfo Lopez Mateos (CTPALM) of Tuxpan, Veracruz; U-3 of the Salamanca Thermoelectric Power Plant (TPP), and U-1 and 2 of the Thermoelectric Power Plant (TPP) Felipe Carrillo Puerto of Valladolid, Yucatan. In the other case the combinations air insufficiency was analyzed as one of the causes of decrement of power of the Unit 1 of the TPP Gral. Manuel Alvarez Moreno of Manzanillo, Colima. The steam generators of Unit 2 of the CTPALM and Unit 3 of the TPP of Salamanca presented faults in the reheater (RH) bank. In this case the recommendations focused to the improvement in the operative conditions to attenuate the faults by corrosion at high temperature. Unlike the CTPALM, in the case of U-3 of Salamanca it was concluded that the redesign of the RH was necessary; for this purpose it was proposed to permute trajectories of hot tubes with the cold ones to make the steam temperature uniform at the RH outlet. In order to evaluate the problems that have appeared in the steam generator of Units 1 and 2 of the TPP Felipe Carrillo Puerto of Valladolid, Yucatan the faults of the tubes of water wall were analyzed and it was found that the main mechanism of overheat is due to the impact of the combustion flame. In the study of the Unit 1 of the TPP Gral. Manuel Alvarez Moreno of Manzanillo, Colima, a methodology was developed to quantify the contribution that the main equipment has in the decrement of the power of the unit; this methodology consists of applying a process of computational simulation based in the design conditions and of real operation. In agreement with the obtained results, it

  1. Improving Vortex Generators to Enhance the Performance of Air-Cooled Condensers in a Geothermal Power Plant

    Energy Technology Data Exchange (ETDEWEB)

    Manohar S. Sohal

    2005-09-01

    Colburn j-factor) associated with deployment of the winglets with circular as well as oval tubes. In general, toe-in (common flow up) type winglets appear to have better performance than the toe-out (common flow down) type winglets. Comparisons of heat transfer and pressure drop results for the elliptical tube versus a circular tube with and without winglets are provided. During the course of their independent research, all of the researchers have established that about 10 to 30% enhancement in Colburn j-factor is expected. However, actual increase in heat transfer rate from a heat exchanger employing finned tubes with winglets may be smaller, perhaps on the order of 2 to 5%. It is also concluded that for any specific application, more full-size experimentation is needed to optimize the winglet design for a specific heat exchanger application. If in place of a circular tube, an oval tube can be economically used in a bundle, it is expected that the pressure drop across the tube bundle with the application of vortex generators (winglets) will be similar to that in a conventional circular tube bundle. It is hoped that the results of this research will demonstrate the benefits of applying vortex generators (winglets) on the fins to improve the heat transfer from the air-side of the tube bundle.

  2. Grooming Great Urban Teachers

    Science.gov (United States)

    Foster, Michele; Lewis, Jeffrey; Onafowora, Laura

    2005-01-01

    Master teachers working in real urban classrooms have shared their exemplary teaching practices in an After-School Pedagogical Laboratory (L-TAPL), a program for elementary students that aims to improve the achievement of urban students and the competence of their teachers. The L-TAPL enrichment program curriculum includes language arts, math,…

  3. Improving Mathematics Learning by Integrating Curricular Activities with Innovative and Developmentally Appropriate Digital Apps: Findings from the Next Generation Preschool Math Evaluation

    Science.gov (United States)

    Presser, Ashley Lewis; Vahey, Philip; Dominguez, Ximena

    2015-01-01

    This paper describes findings from a blocked randomized design (BRD) field study conducted to examine the "Next Generation Preschool Math" (NGPM) program's implementation in preschool classrooms and promise in improving young children's mathematic learning. NGPM integrates traditional preschool activities with developmentally appropriate…

  4. Great Ellipse Route Planning Based on Space Vector

    Directory of Open Access Journals (Sweden)

    LIU Wenchao

    2015-07-01

    Full Text Available Aiming at the problem of navigation error caused by unified earth model in great circle route planning using sphere model and modern navigation equipment using ellipsoid mode, a method of great ellipse route planning based on space vector is studied. By using space vector algebra method, the vertex of great ellipse is solved directly, and description of great ellipse based on major-axis vector and minor-axis vector is presented. Then calculation formulas of great ellipse azimuth and distance are deduced using two basic vectors. Finally, algorithms of great ellipse route planning are studied, especially equal distance route planning algorithm based on Newton-Raphson(N-R method. Comparative examples show that the difference of route planning between great circle and great ellipse is significant, using algorithms of great ellipse route planning can eliminate the navigation error caused by the great circle route planning, and effectively improve the accuracy of navigation calculation.

  5. Performance Improvement of a Portable Electric Generator Using an Optimized Bio-Fuel Ratio in a Single Cylinder Two-Stroke Engine

    Directory of Open Access Journals (Sweden)

    Yamada Hiroaki

    2011-11-01

    Full Text Available The performance of an electrical generator using bio-fuel and gasoline blends of different composition as fuel in a single cylinder engine is presented. The effect of an optimized blend ratio of bio-fuel with gasoline on engine performance improvement and thereby on the electrical generator output is studied. Bio-fuels such as ethanol, butanol and methanol are blended with gasoline in different proportions and evaluated for performance. The effects of different bio-fuel/gasoline blending ratios are compared experimentally with that of the gasoline alone using the output power developed by the electric generator as the evaluation parameter. With a composition of 10% ethanol–gasoline, the engine performance is increased up to 6% and with a blending ratio of 20% butanol–gasoline the performance is increased up to 8% compared to the use of 100% gasoline. The investigations are performed on a portable generator used in palm tree harvesting applications.

  6. Electrical machines, in particular generators: superconductor technology in competition with improved conventional technology; Elektrische Maschinen, insbesondere Generatoren: Supraleiter-Technologie im Wettbewerb mit verbesserter konventioneller Technologie

    Energy Technology Data Exchange (ETDEWEB)

    Joho, R.; Ginet, C.; Schleussinger, A.

    2006-07-01

    This final report for the Swiss Federal Office of Energy (SFOE) summarises work done within the framework of a second project on the use of superconductor technology and conventional technology in electrical machines. The two variants, a generator using second-generation high-temperature superconductors (HTSC) and one using improved conventional technology are described and compared. The use of various coolants for the windings of generators of various types and usage is described and the optimisation of winding-geometry is discussed. The refrigeration equipment used to provide low-temperature coolant is looked at and the energy balance for the combination of generator and cooling system is discussed. The conclusions drawn by the project are presented and the advantages offered by both variants are discussed.

  7. 改进量子遗传算法应用于测试数据自动生成的研究%Research on the Improved Quantum Genetic Algorithm Applied to Test Data Automatically Generated

    Institute of Scientific and Technical Information of China (English)

    季海婧; 孙军梅

    2013-01-01

    为了提高测试数据的自动生成效率,提出一种改进的量子遗传算法(IQGA),用以自动生成测试数据.该算法以角度编码染色体,减少染色体存储空间;采用一种新的动态旋转角策略,使种群在测试数据生成的过程中优秀测试数据能得以较好的遗传,促进种群收敛;并通过Hadamard门变异策略提高种群多样性,扩大种群探索路径.利用典型的三角形分类问题进行了验证,实验结果表明,改进的量子遗传算法具有用时短,生成测试数据少,覆盖率高等优点,测试数据自动生成效率高于传统量子遗传算法和遗传算法.%In order to improve the efficiency of the automatic test case generation, this paper proposes an improved quantum genetic algorithm (IQGA), for the automatic test data generation. In the algorithm, chromosome is encoded by the angle, which decreases the storage space greatly; And the new dynamic rotation angle of strategy makes that the good test data can be good heritable in the process of test data generation, and promotes population convergence; Hadamard door mutation strategy improves population diversity to enlarge the search path. The typical triangle category problem is used as verification procedure in this paper, and the experiment results show that the improved quantum genetic algorithm has the advantages of short time, less test data and high coverage, and automatic test case generation are more efficient than traditional quantum genetic algorithm and genetic algorithm.

  8. Modifed Great Basin Extent (Buffered)

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — Two different great basin perimeter files were intersected and dissolved using ArcGIS 10.2.2 to create the outer perimeter of the great basin for use modeling...

  9. Great Lakes Environmental Database (GLENDA)

    Data.gov (United States)

    U.S. Environmental Protection Agency — The Great Lakes Environmental Database (GLENDA) houses environmental data on a wide variety of constituents in water, biota, sediment, and air in the Great Lakes area.

  10. Ecosystem services in the Great Lakes

    Science.gov (United States)

    Steinman, Alan D.; Cardinale, Bradley J; Munns Jr, Wayne R; Ogdahl, Mary E.; Allan, David J; Angadi, Ted; Bartlett, Sarah; Brauman, Kate; Byappanahalli, Muruleedhara; Doss, Matt; Dupont, Diane; Johns, Annie; Kashian, Donna; Lupi, Frank; McIntyre, Peter B.; Miller, Todd; Moore, Michael P.; Muenich, Rebecca Logsdon; Poudel, Rajendra; Price, James; Provencher, Bill; Rea, Anne; Read, Jennifer; Renzetti, Steven; Sohngen, Brent; Washburn, Erica

    2017-01-01

    A comprehensive inventory of ecosystem services across the entire Great Lakes basin is currently lacking and is needed to make informed management decisions. A greater appreciation and understanding of ecosystem services, including both use and non-use services, may have avoided misguided resource management decisions in the past that resulted in negative legacies inherited by future generations. Given the interest in ecosystem services and lack of a coherent approach to addressing this topic in the Great Lakes, a summit was convened involving 28 experts working on various aspects of ecosystem services in the Great Lakes. The invited attendees spanned a variety of social and natural sciences. Given the unique status of the Great Lakes as the world's largest collective repository of surface freshwater, and the numerous stressors threatening this valuable resource, timing was propitious to examine ecosystem services. Several themes and recommendations emerged from the summit. There was general consensus that: 1) a comprehensive inventory of ecosystem services throughout the Great Lakes is a desirable goal but would require considerable resources; 2) more spatially and temporally intensive data are needed to overcome our data gaps, but the arrangement of data networks and observatories must be well-coordinated; 3) trade-offs must be considered as part of ecosystem services analyses; and 4) formation of a Great Lakes Institute for Ecosystem Services, to provide a hub for research, meetings, and training is desirable. Several challenges also emerged during the summit, which are discussed.

  11. Energetic improvement with micro turbines of biogas generated in Rubis WWTP; Aprovechamiento energetico con microturbinas del biogas generado en la EDAR de Rubi

    Energy Technology Data Exchange (ETDEWEB)

    Moragas, L.; Robuste, J.; Vicente, M.; Pozo, A.; Blasco, M.

    2009-07-01

    The WWTP of Rubi (Barcelona, Spain) treats 22.950 m{sup 3}/day by activated sludge system, with mesophilic anaerobic digestion of primary and secondary sludges with a capacity of 3.500 m{sup 3}. Generated biogas is applied by means of indirect heating to digesters at 37 degree centigrade. To improve the energetic performance 2 micro turbines of 65 kW each were installed, with a 29% of unitary electric performance. After 5 months a third turbine was installed to generate more energy in peak hours. this solutions has shown to be very flexible, with reasonable technology and costs. (Author)

  12. Improvement of performance of non-equilibrium MHD disk generator by means of segmented loads; Hiheiko disk gata MHD hatsudenki ni okeru bunkatsu fuka ni yoru seino kaizen

    Energy Technology Data Exchange (ETDEWEB)

    Kobayashi, H.; Okuno, Y.; Kabashima, S. [Tokyo Institute of Technology, Tokyo (Japan)

    1995-08-20

    The performance of non-equilibrium MHD disk generator with segmented loads is examined with {gamma}-{theta} two dimensional numerical simulations. The use of segmented loads is found to improve the generator performance when a low electron temperature plasma is introduced to the channel. The simulation results reveal the desired values of load resistances connected in upstream and downstream regions, respectively. The concept of the segmented loads is considered to be superior to rearranging seed fractions and load resistances. 10 refs., 6 figs., 2 tabs.

  13. Dutch Patient-Generated Subjective Global Assessment (PG-SGA): training improves scores for comprehensibility and difficulty

    NARCIS (Netherlands)

    Sealy, Martine J.; Ottery, Faith; Roodenburg, Jan; Braak, Anne van der; Haven, Danique; Schans, Cees van der; Jager-Wittenaar, Harriët

    2015-01-01

    Rationale: The Patient-Generated Subjective Global Assessment (PG-SGA) is a validated instrument to assess and monitor malnutrition, which consists of both patient-reported and professional-reported items. A professional should be able to correctly interpret all items. Untrained professionals may ex

  14. Possibilities and consequences of the total cumulative exergy loss method in improving the sustainability of power generation

    NARCIS (Netherlands)

    Stougie, L.; Van der Kooi, H.J.

    2014-01-01

    It is difficult to decide which power generation system is the most sustainable when environmental, economic and social sustainability aspects are taken into account. Problems with conventional environmental sustainability assessment methods are that no consensus exists about the applied models and

  15. Improvement of output characteristics of a wind turbine generator by output current control. Shutsuryoku denryu seigyoho ni yoru furyoku hatsuden system no shutsuryoku tokusei kaizen

    Energy Technology Data Exchange (ETDEWEB)

    Kawahito, T. (Takamatsu National College of Technology, Kagawa (Japan)); Suzuki, T. (Tokushima University, Tokushima (Japan). Faculty of Engineering)

    1993-06-01

    Conformity was studied between the wind turbine and generator's output characteristics to effectively collect the wind energy which fluctuates with time. According to the theoretical analysis, it is necessary for the generator-driving torque to be proportional to the revolving speed (n) squared of wind turbine in order that the wind turbine may generate the highest output always regardless of wind velocity. In the output current control method by current controller, the generator's output current (i[sub a]) is controlled so as to satisfy i[sub a]=cn[sup 2], where c is the output current control coefficient, the optimized value of which is 2[alpha][sup 2]Kw/Kt if the generator loss is nil. Therefore, that value is fixed independently of the wind velocity. [alpha] and Kw are the characteristic constants of wind turbine while Kt is the torque coefficient of generator. In order to confirm the effect of the present control method, the output characteristics were studied through simulation with already known systems. In both cases of constant and variable wind velocity, the change in output is similar against the change in c. Different from the resistance load control method, the present control method improves the output characteristics in a wide range of wind velocity even if the c remains fixed. 7 refs., 13 figs., 1 tab.

  16. ADielectric Multilayer Filter for Combining Photovoltaics with a Stirling Engine for Improvement of the Efficiency of Solar Electricity Generation

    Institute of Scientific and Technical Information of China (English)

    寿春晖; 骆仲泱; 王涛; 沈伟东; ROSENGARTEN Gary; 王诚; 倪明江; 岑可法

    2011-01-01

    In this Letter we outline a dielectric multilayer spectrally selective filter designed for solar energy applications. The optical performance of this 78-layer interference filter constructed by TiOx and SiO2 is presented. A hybrid system combining photovoltaic cells with a solar-powered Stirling engine using the designed filter is analyzed. The calculated results show the advantages of this spectrally selective method for solar power generation.%In this Letter we outline a dielectric multilayer spectrally selective filter designed for solar energy applications.The optical performance of this 78-layer interference filter constructed by TiOx and SiO2 is presented.A hybrid system combining photovoltaic cells with a solar-powered Stirling engine using the designed filter is analyzed.The calculated results show the advantages of this spectrally selective method for solar power generation.

  17. Generator cooling hydrogen purity improvement system using hydrogen absorbing alloy; Suiso kyuzo gokin riyo hatsudenkinai suiso jundo kojo system

    Energy Technology Data Exchange (ETDEWEB)

    Takeda, H.; Kabutomori, T.; Wakisaka, Y. [Japan Steel Works, Ltd., Tokyo (Japan); Nishimura, Y.; Kogi, T.; Sato, J.; Haruki, N. [Kansai Electric Power Co. Inc., Osaka (Japan); Fujita, T. [Mitsubishi Electric Corp., Tokyo (Japan)

    1998-09-15

    Described herein is a system which uses a hydrogen-absorbing alloy to purify a hydrogen gas stream used as a coolant for power generator. Hydrogen in the stream containing impurities such as nitrogen can be selectively absorbed by sufficiently cooled hydrogen-absorbing alloy. Impurity gases concentrated in the alloy pores are released, and then the alloy is heated to release hydrogen. This purifies hydrogen to at least 99.99%. This system essentially consists of an hydrogen-absorbing unit, hot water production/supply system which circulates hot water of 80 to 90degC to release hydrogen out of the alloy, pretreatment unit, and temperature and pressure sensors. It is confirmed, by the test in which the system is connected to a commercial power generator of 600MW, that the system can be continuously operated to purify hydrogen to at least 99.9% for an extended period. 4 refs., 18 figs., 1 tab.

  18. The great transition.

    Science.gov (United States)

    Lieberthal, Kenneth; Lieberthal, Geoffrey

    2003-10-01

    As China's economy grows and opens further, the opportunity it presents to multinationals is changing. Foreign companies are moving to country development and new strategic choices. Now, foreign firms can actually go after the Chinese domestic market, and it's worth going after. Improvements in China's infrastructure, workforce, and regulatory environment are making it possible for companies to lower their costs to reap new competitive advantages. Multifaceted and often-shifting risks accompany this shifting opportunity. The reforms required for admission into the WTO will be politically difficult for China to implement, and its progress will be slowed by the scarcity of resources for the country's shaky banking system, the inadequacy of the social safety net, environmental problems, and local governments' cash shortage. China's breathtaking 9% average annual GDP growth rests on an unsteady foundation of overcapitalized state-owned enterprises, which have oversupplied many markets, and fiercely protectionist regional government officials pursuing growth-at-almost-all-costs policies. Frequent changes in regulations, bureaucracies, and reporting relationships will continue to make planning difficult, and, as the SARS epidemic demonstrated, there is always the potential for serious disruptions. But for at least the next ten years, multinationals should be the biggest winners in China. To reap the benefits, a multinational must properly nest its effort into its overall organization, show "one face to China" at the national level but also tailor local strategies, be wary of joint ventures, and mitigate risk, in particular the theft of intellectual property. China is a major opportunity for companies that forthrightly face its complexities. It will remain largely inscrutable--and unprofitable--for the rest.

  19. Use of Reference Ear Plug to improve accuracy of lateral cephalograms generated from cone-beam computed tomography scans

    OpenAIRE

    Hwang, Hyeon-Shik; Lee, Kyung-Min; Uhm, Gi-Soo; Cho, Jin-Hyoung; McNamara, James A.

    2013-01-01

    Objective The purpose of this study was to evaluate the effectiveness of the use of Reference Ear Plug (REP) during cone-beam computed tomography (CBCT) scan for the generation of lateral cephalograms from CBCT scan data. Methods Two CBCT scans were obtained from 33 adults. One CBCT scan was acquired using conventional methods, and the other scan was acquired with the use of REP. Virtual lateral cephalograms created from each CBCT image were traced and compared with tracings of the real cepha...

  20. A Dielectric Multilayer Filter for Combining Photovoltaics with a Stirling Engine for Improvement of the Efficiency of Solar Electricity Generation

    Science.gov (United States)

    Shou, Chun-Hui; Luo, Zhong-Yang; Wang, Tao; Shen, Wei-Dong; Rosengarten, Gary; Wang, Cheng; Ni, Ming-Jiang; Cen, Ke-Fa

    2011-12-01

    In this Letter we outline a dielectric multilayer spectrally selective filter designed for solar energy applications. The optical performance of this 78-layer interference filter constructed by TiOx and SiO2 is presented. A hybrid system combining photovoltaic cells with a solar-powered Stirling engine using the designed filter is analyzed. The calculated results show the advantages of this spectrally selective method for solar power generation.

  1. LEARNING STRATEGY IMPLEMENTATION OF GENERATIVE LEARNING ASSISTED SCIENTIST’S CARD TO IMPROVE SELF EFFICACY OF JUNIOR HIGH SCHOOL STUDENT IN CLASS VIII

    Directory of Open Access Journals (Sweden)

    R. Yuliarti

    2016-01-01

    Full Text Available In general, self-efficacy of the students is still low. This study aims to determine the learning strategies implementation of generative learning assisted scientist's card in improving self-efficacy and cognitive learning outcomes of the students. The study designed form One Group Pretest-Posttest Design. The improvement of self-efficacy can be determined from the change in the questionnaire score before and after the learning and observations during the learning process. Cognitive learning outcomes are known from pretest and posttest scores. To determine the improvement, the data were analyzed by using the gain test. The results showed that N-gain of self-efficacy is 0.13 (low and N-gain of cognitive learning is 0.60 (medium. Based on the observation, students’ self-efficacy has increased each meeting. Cognitive learning results also achieved mastery learning as big as 72.88%. It could be concluded that the learning strategy of generative learning assisted scientist's card can improve self efficacy and cognitive learning outcomes of the students.Pada umumnya, self efficacy yang dimiliki siswa masih rendah. Penelitian ini bertujuan untuk mengetahui penerapan strategi pembelajaran generative learning berbantuan scientist’s card dalam meningkatkan self efficacy dan  hasil belajar  kognitif siswa.  Desain penelitian berbentuk One Group Pretest-Posttest Design. Peningkatan self efficacy dapat diketahui dari perubahan  skor angket sebelum dan sesudah pembelajaran dan hasil observasi selama pembelajaran. Hasil  belajar kognitif diketahui dari skor pretest dan posttest. Untuk mengetahui peningkatannya, data yang diperoleh dianalisis menggunakan uji gain. Hasil penelitian menunjukkan bahwa peningkatan self efficacy berkatagori rendah dan peningkatan hasil belajar kognitif berkatagori sedang. Berdasarkan hasil observasi, self efficacy siswa setiap pertemuan meningkat. Hasil belajar ranah kognitif juga mencapai ketuntasan belajar .Jadi dapat

  2. Improved process for generating ClF/sub 3/ from ClF and F/sub 2/

    Science.gov (United States)

    Reiner, R.H.; Pashley, J.H.; Barber, E.J.

    The invention is an improvement in the process for producing gaseous ClF/sub 3/ by reacting ClF and F/sub 2/ at elevated temperature. The improved process comprises conducting the reaction in the presence of NiF/sub 2/, which preferably is in the form of particles or in the form of a film or layer on a particulate substrate. The nickel fluoride acts as a reaction catalyst, significantly increasing the reaction rate and thus permitting valuable reductions in process temperature, pressure, and/or reactor volume.

  3. Improved layer-based method for rapid hologram generation and real-time interactive holographic display applications.

    Science.gov (United States)

    Chen, J-S; Chu, D P

    2015-07-13

    Layer-based method has been proposed as an efficient approach to calculate holograms for holographic image display. This paper further improves its calculation speed and depth cues quality by introducing three different techniques, an improved coding scheme, a multilayer depth- fused 3D method and a fraction method. As a result the total computation time is reduced more than 4 times, and holographic images with accommodation cue are calculated in real time to interactions with the displayed image in a proof-of-concept setting of head-mounted holographic displays.

  4. The Aryl Hydrocarbon Receptor Antagonist StemRegenin1 Improves In Vitro Generation of Highly Functional Natural Killer Cells from CD34(+) Hematopoietic Stem and Progenitor Cells.

    Science.gov (United States)

    Roeven, Mieke W H; Thordardottir, Soley; Kohela, Arwa; Maas, Frans; Preijers, Frank; Jansen, Joop H; Blijlevens, Nicole M; Cany, Jeannette; Schaap, Nicolaas; Dolstra, Harry

    2015-12-15

    Early natural killer (NK)-cell repopulation after allogeneic stem cell transplantation (allo-SCT) has been associated with reduced relapse rates without an increased risk of graft-versus-host disease, indicating that donor NK cells have specific antileukemic activity. Therefore, adoptive transfer of donor NK cells is an attractive strategy to reduce relapse rates after allo-SCT. Since NK cells of donor origin will not be rejected, multiple NK-cell infusions could be administered in this setting. However, isolation of high numbers of functional NK cells from transplant donors is challenging. Hence, we developed a cytokine-based ex vivo culture protocol to generate high numbers of functional NK cells from granulocyte colony-stimulating factor (G-CSF)-mobilized CD34(+) hematopoietic stem and progenitor cells (HSPCs). In this study, we demonstrate that addition of aryl hydrocarbon receptor antagonist StemRegenin1 (SR1) to our culture protocol potently enhances expansion of CD34(+) HSPCs and induces expression of NK-cell-associated transcription factors promoting NK-cell differentiation. As a result, high numbers of NK cells with an active phenotype can be generated using this culture protocol. These SR1-generated NK cells exert efficient cytolytic activity and interferon-γ production toward acute myeloid leukemia and multiple myeloma cells. Importantly, we observed that NK-cell proliferation and function are not inhibited by cyclosporin A, an immunosuppressive drug often used after allo-SCT. These findings demonstrate that SR1 can be exploited to generate high numbers of functional NK cells from G-CSF-mobilized CD34(+) HSPCs, providing great promise for effective NK-cell-based immunotherapy after allo-SCT.

  5. Thermochemistry and Kinetics for Designer Molecules Additives to Energetic Materials for Improved Performance: Thermal Generation of Hydrazine

    Science.gov (United States)

    2007-09-28

    Functional, Moller Plesset ab initio, and the CBS- QB3 (Complete Basis Set) computational chemistry methods. In each case the elimination of... QB3 calculation energies and by improving the the entropy S o (T) and heat capacity Cp(T) contributions from values further analysis of the internal

  6. Improving the SMAC atmospheric correction code by analysis of Meteosat Second Generation NDVI and surface reflectance data

    DEFF Research Database (Denmark)

    Proud, Simon Richard; Rasmussen, M.O.; Fensholt, R.;

    2010-01-01

    ) radiative transfer model and the Simplified Method for Atmospheric Correction (SMAC) codes have been used for this atmospheric correction, but previous studies have shown that in a number of situations the quality of correction provided by the SMAC is low. This paper describes a method designed to improve...

  7. Improved Sensitization of Zinc Oxide Nanorods by Cadmium Telluride Quantum Dots through Charge Induced Hydrophilic Surface Generation

    Directory of Open Access Journals (Sweden)

    Karthik Laxman

    2014-01-01

    Full Text Available This paper reports on UV-mediated enhancement in the sensitization of semiconductor quantum dots (QDs on zinc oxide (ZnO nanorods, improving the charge transfer efficiency across the QD-ZnO interface. The improvement was primarily due to the reduction in the interfacial resistance achieved via the incorporation of UV light induced surface defects on zinc oxide nanorods. The photoinduced defects were characterized by XPS, FTIR, and water contact angle measurements, which demonstrated an increase in the surface defects (oxygen vacancies in the ZnO crystal, leading to an increase in the active sites available for the QD attachment. As a proof of concept, a model cadmium telluride (CdTe QD solar cell was fabricated using the defect engineered ZnO photoelectrodes, which showed ∼10% increase in photovoltage and ∼66% improvement in the photocurrent compared to the defect-free photoelectrodes. The improvement in the photocurrent was mainly attributed to the enhancement in the charge transfer efficiency across the defect rich QD-ZnO interface, which was indicated by the higher quenching of the CdTe QD photoluminescence upon sensitization.

  8. A Comprehensive Design Approach of Power Electronic-Based Distributed Generation Units Focused on Power Quality Improvement

    DEFF Research Database (Denmark)

    Esparza, Miguel; Segundo-Ramirez, Juan; Nunez, Ciro

    2017-01-01

    The undesirable harmonic distortion produced by distributed generation units (DGUs) based on power electronic inverters presents operating and power quality challenges in electric systems. ‡e level of distortion depends on the internal elements of the DGUs as well as on the characteristics...... of the grid, loads, controls, among others. ‡is paper presents a comprehensive method, focused on power quality indexes and e�ciency for the design of micro-grids with multiple DGUs interconnected to the AC grid through three phase multi-Megawatt medium-voltage PWM voltage source inverters (PWM-VSI). ‡e...

  9. Use of air jet vortex generators leading to improved energy capture and power regulation of a wind turbine

    Energy Technology Data Exchange (ETDEWEB)

    Oliver, A.; Wootton, L.R. [City Univ., London (United Kingdom); Prats, J. [Ecotecnia SCC Ltd. (United Kingdom)

    1997-06-01

    City University and Ecotecnia have recently completed a project funded by the European Union Joule II programme on the optimisation and control of wind turbines. The blade set of a 150 kW stall regulated wind turbine was modified with air jet vortex generators and tested at full scale. This was done primarily to increase its energy yield by reducing energy loss in the region of the power curve `knee`, but also to allow a degree of power regulation in high wind speeds. Of these, the former has so far been demonstrated successfully. (author)

  10. Origin of the improved photocatalytic activity of Cu incorporated TiO2 for hydrogen generation from water

    Science.gov (United States)

    Hu, Qianqian; Huang, Jiquan; Li, Guojing; Jiang, Yabin; Lan, Hai; Guo, Wang; Cao, Yongge

    2016-09-01

    Cu incorporated TiO2 has been regarded as a low-cost photocatalyst with excellent photocatalytic performance for water splitting. Here we try to exploit the origin of its high reactivity by fabricating a series of Cu incorporated TiO2 films with the same Cu content under different atmosphere. Based on the comprehensive structure and surface characterizations, it is found that CuO is unstable and will be reduced to Cu2O or even to metallic Cu under light irradiation during the photocatalytic reaction, and Cu2O is an efficient co-catalyst that promotes the separation of photogenerated carriers while metallic Cu can further boost the photocatalytic activity. Besides, it is also noticed that the chemisorbed oxygen on the particle surface blocks the water splitting. By depositing TiO2 films under oxygen rich condition, oxygen vacancy is decreased greatly, which facilitates the removal of chemisorbed oxygen and the formation of metallic Cu during photocatalytic reaction, resulting in an ultra-high H2 evolution rate of 2.80 μmol cm-2 h-1, which is about 55 times higher than that of pure TiO2.

  11. Next generation breeding.

    Science.gov (United States)

    Barabaschi, Delfina; Tondelli, Alessandro; Desiderio, Francesca; Volante, Andrea; Vaccino, Patrizia; Valè, Giampiero; Cattivelli, Luigi

    2016-01-01

    The genomic revolution of the past decade has greatly improved our understanding of the genetic make-up of living organisms. The sequencing of crop genomes has completely changed our vision and interpretation of genome organization and evolution. Re-sequencing allows the identification of an unlimited number of markers as well as the analysis of germplasm allelic diversity based on allele mining approaches. High throughput marker technologies coupled with advanced phenotyping platforms provide new opportunities for discovering marker-trait associations which can sustain genomic-assisted breeding. The availability of genome sequencing information is enabling genome editing (site-specific mutagenesis), to obtain gene sequences desired by breeders. This review illustrates how next generation sequencing-derived information can be used to tailor genomic tools for different breeders' needs to revolutionize crop improvement. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  12. Improving heat generation of magnetic nanoparticles by pre-orientation of particles in a static three tesla magnetic field

    Science.gov (United States)

    Beck, Mathias M.; Lammel, Christian; Gleich, Bernhard

    2017-04-01

    Inductive heating of electrically insulating materials like fiberglass reinforced thermoplastics (FRTP) without susceptors is not possible. However, due to their low thermal conductivity a volumetric heat generation method is advisable to reach short heating times to melt this material for reshaping. This can be done with magnetic nanoparticles as susceptors within the thermoplastic of the FRTP using Néel relaxation. During the heating process the particle's magnetic moment rotates with the field while the particle itself is fixed within the thermoplastic. Therefore the heat dissipation of each particle depends on its orientation within the field. To achieve the maximum heat generation of the particles we pre-oriented the particles within a plastic at the best angle to the applied AC field for induction. To do this, five mass percent nanoparticles were dispersed in an epoxy resin, which was then hardened at room temperature in a static three Tesla magnetic field. After its solidification the heating behavior of the sample was compared to a reference sample, which was hardened without a field. The oriented particles showed an increased heating rate when oriented parallel to the applied AC field. The absorption rate was 3.3 times as high as the undirected reference sample. When the alternating electromagnetic field was perpendicular to the oriented particles, the specific absorption rate was similar to that of the reference sample. We compare this result with theory and with calculations from literature, and conduct a numerical simulation.

  13. Persistent organic pollutants in the great lakes

    Energy Technology Data Exchange (ETDEWEB)

    Hites, R.A. (ed.) [Indiana Univ., Bloomington, IN (United States). School of Public and Environmental Affairs

    2006-07-01

    The environment around the Laurentian Great Lakes region has been adversely affected by agricultural runoff, urban waste, industrial discharge, landfill leachate, and atmospheric deposition. Although there have been some improvements over the last 20 years, persistent toxic organic pollutants are now a serious problem. This book brings together what is known about the major classes of these pollutants in the Great Lakes. Each chapter reviews our knowledge of the extent of contamination of the various parts of the Great Lakes ecosystem (air, water, sediment, fishes, birds, etc.), what is known about the trends over time of this contamination, and knowledge about the mechanisms by which these pollutants are mobilized in the lakes. Detailed information is presented on polychlorinated biphenyls, polychlorinated dibenzo-p-dioxins and dibenzofurans, pesticides, toxaphene, polychlorinated naphthalenes, polycyclic aromatic hydrocarbons, brominated flame retardants, and perfluoroalkyl acids. These reviews make this volume an invaluable resource for all those involved in environmental research, measurements, and decision making. (orig.)

  14. In vitro generation of monocyte-derived macrophages under serum-free conditions improves their tumor promoting functions.

    Directory of Open Access Journals (Sweden)

    Flora Rey-Giraud

    Full Text Available The tumor promoting role of M2 macrophages has been described in in vivo models and the presence of macrophages in certain tumor types has been linked to a poor clinical outcome. In light of burgeoning activities to clinically develop new therapies targeting tumor-associated macrophages (TAMs, reliable in vitro models faithfully mimicking the tumor promoting functions of TAMs are required. Generation and activation of human monocyte-derived macrophages (MDM in vitro, described as M1 or M2 macrophages attributed with tumoricidal or tumor-promoting functions, respectively, has been widely reported using mainly serum containing culture methods. In this study, we compared the properties of macrophages originating from monocytes cultured either in media containing serum together with M-CSF for M2 and GM-CSF for M1 macrophages or in serum-free media supplemented with M-CSF or GM-CSF and cytokines such as IL-4, IL-10 to induce activated M2 or LPS together with IFN-γ to generate activated M1 phenotype. We observed differences in cell morphology as well as increased surface receptor expression levels in serum-containing culture whereas similar or higher cytokine production levels were detected under serum-free culture conditions. More importantly, MDM differentiated under serum-free conditions displayed enhanced tumoricidal activity for M1 and tumor promoting property for M2 macrophages in contrast to MDM differentiated in the presence of serum. Moreover, evaluation of MDM phagocytic activity in serum free condition resulted in greater phagocytic properties of M2 compared to M1. Our data therefore confirm the tumor promoting properties of M2 macrophages in vitro and encourage the targeting of TAMs for cancer therapy.

  15. Great Meadows National Wildlife Refuge (Sudbury Division) [Land Status Map

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This map was produced by the Division of Realty to depict landownership at Great Meadows National Wildlife Refuge. It was generated from rectified aerial...

  16. The Time Scale of Recombination Rate Evolution in Great Apes

    NARCIS (Netherlands)

    Stevison, Laurie S; Woerner, August E; Kidd, Jeffrey M; Kelley, Joanna L; Veeramah, Krishna R; McManus, Kimberly F; Bustamante, Carlos D; Hammer, Michael F; Wall, Jeffrey D

    2016-01-01

    We present three linkage-disequilibrium (LD)-based recombination maps generated using whole-genome sequence data from 10 Nigerian chimpanzees, 13 bonobos, and 15 western gorillas, collected as part of the Great Ape Genome Project (Prado-Martinez J, et al. 2013. Great ape genetic diversity and popula

  17. The Time Scale of Recombination Rate Evolution in Great Apes

    NARCIS (Netherlands)

    Stevison, Laurie S; Woerner, August E; Kidd, Jeffrey M; Kelley, Joanna L; Veeramah, Krishna R; McManus, Kimberly F; Bustamante, Carlos D; Hammer, Michael F; Wall, Jeffrey D

    We present three linkage-disequilibrium (LD)-based recombination maps generated using whole-genome sequence data from 10 Nigerian chimpanzees, 13 bonobos, and 15 western gorillas, collected as part of the Great Ape Genome Project (Prado-Martinez J, et al. 2013. Great ape genetic diversity and

  18. The Time Scale of Recombination Rate Evolution in Great Apes

    NARCIS (Netherlands)

    Stevison, Laurie S; Woerner, August E; Kidd, Jeffrey M; Kelley, Joanna L; Veeramah, Krishna R; McManus, Kimberly F; Bustamante, Carlos D; Hammer, Michael F; Wall, Jeffrey D

    2016-01-01

    We present three linkage-disequilibrium (LD)-based recombination maps generated using whole-genome sequence data from 10 Nigerian chimpanzees, 13 bonobos, and 15 western gorillas, collected as part of the Great Ape Genome Project (Prado-Martinez J, et al. 2013. Great ape genetic diversity and popula

  19. How users experience great products

    NARCIS (Netherlands)

    Ortiz Nicolas, J.C.; Aurisicchio, M.; Desmet, P.M.A.

    2013-01-01

    This study reports qualitative research about how users experience great products. Eighteen interviews were conducted in which participants were asked to bring along a ‘great’ product that they own. During the interviews participants explained why they consider a product great and how they experienc

  20. Great Explorers to the East.

    Science.gov (United States)

    Baker, Rosalie F., Ed.; Baker, Charles F. III, Ed.

    1990-01-01

    This issue of "Calliope," a world history magazine for young people is devoted to "Great Explorers of the East" and features articles on famous explorers of the eastern hemisphere. The following articles are included: "Ancient Egyptian Mariners"; "Alexander: The Great Reconciler"; "Marco Polo:…

  1. What Caused the Great Depression?

    Science.gov (United States)

    Caldwell, Jean; O'Driscoll, Timothy G.

    2007-01-01

    Economists and historians have struggled for almost 80 years to account for the American Great Depression, which began in 1929 and lasted until the early years of World War II. In this article, the authors discuss three major schools of thought on the causes of the Great Depression and the long failure of the American economy to return to full…

  2. Great Explorers to the East.

    Science.gov (United States)

    Baker, Rosalie F., Ed.; Baker, Charles F. III, Ed.

    1990-01-01

    This issue of "Calliope," a world history magazine for young people is devoted to "Great Explorers of the East" and features articles on famous explorers of the eastern hemisphere. The following articles are included: "Ancient Egyptian Mariners"; "Alexander: The Great Reconciler"; "Marco Polo: Describing the World"; "By Water to India";…

  3. Rethinking China's new great wall

    National Research Council Canada - National Science Library

    Ma, Zhijun; Melville, David S; Liu, Jianguo; Chen, Ying; Yang, Hongyan; Ren, Wenwei; Zhang, Zhengwang; Piersma, Theunis; Li, Bo

    2014-01-01

    ... enclosed by thousands of kilometers of seawalls, whose length exceeds that of China’s famous ancient “Great Wall” (see photos and map). This new “Great Wall,” covering 60% of the total length of coast-line along mainland China...

  4. Rijndael密钥生成算法存在的问题与改进%Problem and Improvement of Rijndael Key Generation Algorithm

    Institute of Scientific and Technical Information of China (English)

    胡亮; 刘博超; 袁巍; 贾旭; 林海群; 贺瑞莲

    2009-01-01

    基于Serpent密钥生成算法, 提出一种改进的Rijndael密钥生成算法. 在改进过程中, 采用由连续两轮密钥生成下一轮密钥的方法, 使得Rijndael密钥生成算法在密钥生成过程中同样具有不可推导的特点, 从而提高了原有算法在密钥生成方面的安全性.%For improving the security of Rijndael algorithm in the process of key generation, a character called non-deduction was summarized. With this character, the Rijndael key schedule was improved. We made use of continuous two round keys to generate the next round keys, which made the Rijndael key schedule also possess the character non-deduction. Therefore the security of the original key generation algorithm was enhanced.

  5. Closing the social-class achievement gap: a difference-education intervention improves first-generation students' academic performance and all students' college transition.

    Science.gov (United States)

    Stephens, Nicole M; Hamedani, MarYam G; Destin, Mesmin

    2014-04-01

    College students who do not have parents with 4-year degrees (first-generation students) earn lower grades and encounter more obstacles to success than do students who have at least one parent with a 4-year degree (continuing-generation students). In the study reported here, we tested a novel intervention designed to reduce this social-class achievement gap with a randomized controlled trial (N = 168). Using senior college students' real-life stories, we conducted a difference-education intervention with incoming students about how their diverse backgrounds can shape what they experience in college. Compared with a standard intervention that provided similar stories of college adjustment without highlighting students' different backgrounds, the difference-education intervention eliminated the social-class achievement gap by increasing first-generation students' tendency to seek out college resources (e.g., meeting with professors) and, in turn, improving their end-of-year grade point averages. The difference-education intervention also improved the college transition for all students on numerous psychosocial outcomes (e.g., mental health and engagement).

  6. Is the Wii Fit a new-generation tool for improving balance, health and well-being? A pilot study.

    Science.gov (United States)

    Nitz, J C; Kuys, S; Isles, R; Fu, S

    2010-10-01

    The Nintendo Wii Fit is a new product that is purported to improve balance, strength, flexibility, fitness and general well-being. Currently, there are no controlled trials published to support such claims. The aim of this research was to determine the feasibility of Wii Fit in improving balance, strength, flexibility and fitness for healthy women aged between 30 and 60 years. Ten women aged 30-58 years were recruited to the study. Intervention involved a 30-min session, twice weekly for 10 weeks. The manufacturer's pre-programmed Wii Fit regime determined for age and physical ability was followed. All women were assessed before and after the 10 weeks' intervention. Demographic information collected included age, weight, and self-reported information related to habitual physical activity, regular medication, hormone replacement therapy and well-being. Balance measures included the modified Clinical Test for Sensory Integration of Balance, reaction time and unilateral stance with velocity of sway recorded. Clinical measures of balance and mobility included the Step Test, the timed Up & Go test (TUG) and the TUG(cognitive). Somatosensory testing included touch, vibration and knee-joint re-positioning ability; ankle flexibility and the muscle strengths of quadriceps, hip abductors and adductors were also measured. Cardiovascular fitness was measured using a 6-min walk test. Balance (unilateral stance, eyes open (p balance and strength that needs confirmation by statistically powered studies.

  7. A Hybrid Method Combining Improved K-means Algorithm with BADA Model for Generating Nominal Flight Profiles

    Institute of Scientific and Technical Information of China (English)

    TangXinmin; GuJunwei; ShenZhiyuan; ChenPing; LiBo

    2016-01-01

    A high-precision nominal flight profile,involving controllers′intentions is critical for 4D traj ectory esti-mation in modern automatic air traffic control systems.We proposed a novel method to effectively improve the ac-curacy of the nominal flight profile,including the nominal altitude profile and the speed profile.First,considering the characteristics of traj ectory data,we developed an improved K-means algorithm.The approach was to measure the similarity between different altitude profiles by integrating the space warp edit distance algorithm,thereby to acquire several fitted nominal flight altitude profiles.This approach breaks the constraints of traditional K-means algorithms.Second,to eliminate the influence of meteorological factors,we introduced historical gridded binary data to determine the en-route wind speed and temperature via inverse distance weighted interpolation.Finally,we facilitated the true airspeed determined by speed triangle relationships and the calibrated airspeed determined by aircraft data model to extract a more accurate nominal speed profile from each cluster,therefore we could describe the airspeed profiles above and below the airspeed transition altitude,respectively.Our experimental results showed that the proposed method could obtain a highly accurate nominal flight profile,which reflects the actual aircraft flight status.

  8. An Improved Nuclear Recoil Calibration in the LUX Detector Using a Pulsed D-D Neutron Generator

    Science.gov (United States)

    Huang, Dongqing

    2017-01-01

    The LUX dark matter search experiment is a 370 kg (250 kg active mass) two-_phase liquid/gas xenon time projection chamber located at the 4850 ft level of the Sanford Underground Research Facility in Lead, SD. The first absolute charge (Qy) and light (Ly) measurement performed in situ in the LUX detector with a D-D calibration technique for nuclear recoil spanning 0.7 to 74 keV and 1.1 to 74 keV respectively have been reported in. The D-D calibration has subsequently been further improved by incorporating pulsing technique, i.e. the D-D neutron production is concentrated within narrow pulses (20 us / 250 Hz) with the timing information recorded. This technique allows the suppression of accidental backgrounds in D-D neutron data and also provides increased sensitivity for the lower energy NR calibrations. I will report the improved NR absolute Qy and Ly measurements using the pulsed D-D calibration technique performed in situ in the LUX detector. Brown University, Large Underground Xenon(LUX) Collaboration.

  9. Kinematic strategies underlying improvement in the acquisition of a sequential finger task with self-generated vs. Cued repetition training.

    Directory of Open Access Journals (Sweden)

    Jason Friedman

    Full Text Available Many motor skills, such as typing, consist of articulating simple movements into novel sequences that are executed faster and smoother with practice. Dynamics of re-organization of these movement sequences with multi-session training and its dependence on the amount of self-regulation of pace during training is not yet fully understood. In this study, participants practiced a sequence of key presses. Training sessions consisted of either externally (Cued or self-initiated (Uncued training. Long-term improvements in performance speed were mainly due to reducing gaps between finger movements in both groups, but Uncued training induced higher gains. The underlying kinematic strategies producing these changes and the representation of the trained sequence differed significantly across subjects, although net gains in speed were similar. The differences in long-term memory due to the type of training and the variation in strategies between subjects, suggest that the different neural mechanisms may subserve the improvements observed in overall performance.

  10. Next-generation long-term transplant clinics: improving resource utilization and the quality of care through health information technology.

    Science.gov (United States)

    Rioth, M J; Warner, J; Savani, B N; Jagasia, M

    2016-01-01

    By the year 2020, potentially one-half a million hematopoietic cell transplant (HCT) recipients will need long-term follow-up care to address not only chronic GvHD but also multiple other late consequences of transplant. Despite this increase in patients, there will not be a concomitant increase in the HCT workforce. Thus, the future of long-term patient management will require a new 'next-generation' clinical model that utilizes technological solutions to make the care of the HCT patient efficient, safe and cost-effective. Guideline-based decision support will be embedded in clinical workflows. Documentation requirements will be reduced as automated data collection from electronic medical records (EMRs) will populate registries and provide feedback for a rapid learning health system. Interoperable EMRs will disseminate treatment protocols to multiple care providers in a distributed long-term clinic model, such that providers outside of the transplant center can provide services closer to the patient. Patients will increase their participatory role through patient portals and mobile devices. At Vanderbilt, we have responded to some of these future challenges by embedding guideline-based decision support, structuring clinical documentation and being early adopters of communication technology. This manuscript describes the current state of some of these innovations, and a vision for the future of the long-term transplant clinic.

  11. Next-generation sequencing improves thalassemia carrier screening among premarital adults in a high prevalence population: the Dai nationality, China.

    Science.gov (United States)

    He, Jing; Song, Wenhui; Yang, Jinlong; Lu, Sen; Yuan, Yuan; Guo, Junfu; Zhang, Jie; Ye, Kai; Yang, Fan; Long, Fangfang; Peng, Zhiyu; Yu, Haijing; Cheng, Le; Zhu, Baosheng

    2017-09-01

    Thalassemia is one of the most common monogenic diseases in southwestern China, especially among the Dai ethnic group. Here, we explore the feasibility of a next-generation sequencing (NGS) screening method specifically for the Dai people. Blood samples were obtained from Dai people for premarital screening. Double-blind, parallel hemoglobinopathy screening was conducted using both traditional hematological methods (red cell indexes and hemoglobin electrophoresis, then DNA sequencing) and an NGS approach. Among 951 tested individuals, we found a thalassemia carrier rate of 49.5% (471/951) using the NGS screen, in contrast to 22.0% (209/951) found using traditional methods. Almost 74.8% (217/290) of α-thalassemia carriers and 30.5% (25/82) of composite α- and β-thalassemia carriers were missed by traditional screens. The proportion of such α- and β-thalassemia carriers among the Dai people is 8.6% (82/951). For β-thalassemia carriers, the high ratio (66/99) of CD26 mutations may suggest a correlation between CD26 and the environmental adaption of the Dai people. Methodological comparisons demonstrate the superiority of NGS for both sensitivity and specificity, provide a comprehensive assessment of thalassemia screening strategies, and indicate that NGS is a competitive screening method, especially among populations with a high prevalence of disease.Genet Med advance online publication 26 January 2017.

  12. Improving molecular diagnosis of Chinese patients with Charcot-Marie-Tooth by targeted next-generation sequencing and functional analysis

    Science.gov (United States)

    Liu, Zhi-Jun; Ni, Wang; Li, Hong-Fu; Xiao, Bao-Guo; Wu, Zhi-Ying

    2016-01-01

    Charcot-Marie-Tooth (CMT) disease is the most common hereditary peripheral neuropathy. More than 50 causative genes have been identified. The lack of genotype-phenotype correlations in many CMT patients make it difficult to decide which genes are affected. Recently, targeted next-generation sequencing (NGS) has been introduced as an alternative approach for diagnosis of genetic disorders. Here, we applied targeted NGS in combination with PMP22 duplication/deletion analysis to screen causative genes in 22 Chinese CMT families. The novel variants detected by targeted NGS were then further studied in cultured cells. Of the 22 unrelated patients, 8 had PMP22 duplication. The targeted NGS revealed 10 possible pathogenic variants in 11 patients, including 7 previously reported variants and 3 novel heterozygous variants (GJB1: p.Y157H; MFN2: p.G127S; YARS: p.V293M). Further classification of the novel variants according to American College of Medical Genetics and Genomics (ACMG) standards and guidelines and functional analysis in cultured cells indicated that p.Y157H in GJB1 was pathogenic, p.G127S in MFN2 was likely pathogenic, while p.V293M in YARS was likely benign. Our results suggest the potential for targeted NGS to make a more rapid and precise diagnosis in CMT patients. Moreover, the functional analysis is required when the novel variants are indistinct. PMID:27027447

  13. Improving molecular diagnosis of Chinese patients with Charcot-Marie-Tooth by targeted next-generation sequencing and functional analysis.

    Science.gov (United States)

    Li, Li-Xi; Zhao, Shao-Yun; Liu, Zhi-Jun; Ni, Wang; Li, Hong-Fu; Xiao, Bao-Guo; Wu, Zhi-Ying

    2016-05-10

    Charcot-Marie-Tooth (CMT) disease is the most common hereditary peripheral neuropathy. More than 50 causative genes have been identified. The lack of genotype-phenotype correlations in many CMT patients make it difficult to decide which genes are affected. Recently, targeted next-generation sequencing (NGS) has been introduced as an alternative approach for diagnosis of genetic disorders. Here, we applied targeted NGS in combination with PMP22 duplication/deletion analysis to screen causative genes in 22 Chinese CMT families. The novel variants detected by targeted NGS were then further studied in cultured cells. Of the 22 unrelated patients, 8 had PMP22 duplication. The targeted NGS revealed 10 possible pathogenic variants in 11 patients, including 7 previously reported variants and 3 novel heterozygous variants (GJB1: p.Y157H; MFN2: p.G127S; YARS: p.V293M). Further classification of the novel variants according to American College of Medical Genetics and Genomics (ACMG) standards and guidelines and functional analysis in cultured cells indicated that p.Y157H in GJB1 was pathogenic, p.G127S in MFN2 was likely pathogenic, while p.V293M in YARS was likely benign. Our results suggest the potential for targeted NGS to make a more rapid and precise diagnosis in CMT patients. Moreover, the functional analysis is required when the novel variants are indistinct.

  14. Expanding the generation and use of economic and financial data to improve HIV program planning and efficiency: a global perspective.

    Science.gov (United States)

    Holmes, Charles B; Atun, Rifat; Avila, Carlos; Blandford, John M

    2011-08-01

    Cost information is needed at multiple levels of health care systems to inform the public health response to HIV. To date, most attention has been paid to identifying the cost drivers of providing antiretroviral treatment, and these data have driven interventions that have been successful in reducing drug and human resource costs. The need for further cost information, especially for less well-studied areas such as HIV prevention, is particularly acute given global budget constraints and ongoing efforts to extract the greatest possible value from money spent on the response. Cost information can be collected from multiple perspectives and levels of the health care system (site, program, and national levels), and it is critical to choose the appropriate methodology in order to generate the appropriate information for decision-making. Organizations such as United States President's Emergency Plan for AIDS Relief, the Global Fund to Fight AIDS, Tuberculosis, and Malaria, and other organizations are working together to bridge the divide between the fields of economics and HIV program implementation by accelerating the collection of cost data and building further local demand and capacity for their use.

  15. Improved depth perception with three-dimensional auxiliary display and computer generated three-dimensional panoramic overviews in robot-assisted laparoscopy.

    Science.gov (United States)

    Wieringa, Fokko P; Bouma, Henri; Eendebak, Pieter T; van Basten, Jean-Paul A; Beerlage, Harrie P; Smits, Geert A H J; Bos, Jelte E

    2014-04-01

    In comparison to open surgery, endoscopic surgery offers impaired depth perception and narrower field-of-view. To improve depth perception, the Da Vinci robot offers three-dimensional (3-D) video on the console for the surgeon but not for assistants, although both must collaborate. We improved the shared perception of the whole surgical team by connecting live 3-D monitors to all three available Da Vinci generations, probed user experience after two years by questionnaire, and compared time measurements of a predefined complex interaction task performed with a 3-D monitor versus two-dimensional. Additionally, we investigated whether the complex mental task of reconstructing a 3-D overview from an endoscopic video can be performed by a computer and shared among users. During the study, 925 robot-assisted laparoscopic procedures were performed in three hospitals, including prostatectomies, cystectomies, and nephrectomies. Thirty-one users participated in our questionnaire. Eighty-four percent preferred 3-D monitors and 100% reported spatial-perception improvement. All participating urologists indicated quicker performance of tasks requiring delicate collaboration (e.g., clip placement) when assistants used 3-D monitors. Eighteen users participated in a timing experiment during a delicate cooperation task in vitro. Teamwork was significantly (40%) faster with the 3-D monitor. Computer-generated 3-D reconstructions from recordings offered very wide interactive panoramas with educational value, although the present embodiment is vulnerable to movement artifacts.

  16. Development of generator-cooling hydrogen purity improvement system using hydrogen absorbing alloy; Suiso kyuzo gokin ni yoru hatsudenkinai suiso jundo kojo system no kaihatsu

    Energy Technology Data Exchange (ETDEWEB)

    Nishimura, Y.; Sato, J.; Haruki, N.; Kogi, T.; Okuno, Y. [The Kansai Electric Power Co. Inc., Osaka (Japan); Takeda, H.; Wakisaka, Y. [The Japan Steel Works, Ltd., Tokyo (Japan); Fujita, T. [Mitsubishi Electric Corp., Tokyo (Japan)

    1997-01-31

    A generator-cooling hydrogen purity improvement system was developed by utilizing hydrogen absorbing and discharging functions of hydrogen storage alloy. For demonstration test with an actual machine, four elements, Ca, Ni, Mm and Al, were used as hydrogen storage alloys. To treat hydrogen gas with a wide range of purity and reduce hydrogen gas feed, flow operation for hydrogen purity improvement, batch operation, and recycle operation for maintaining the hydrogen purity were performed. As a result of the generator-cooling hydrogen purity improvement demonstration test, it was found that the hydrogen purity can be enhanced from 97.69% before operation to 99.9% after operation for 104 hours and to 99.95% after operation for 140 hours. The hydrogen recovery rates during flow test and batch test were between 92 and 95%. For the hydrogen purity maintaining test, it was confirmed that the high hydrogen purity of 99.9% has been continuously maintained for 140 days, and that the hydrogen recovery rate was over 99%. 2 refs., 15 figs., 3 tabs.

  17. Improved cider fermentation performance and quality with newly generated Saccharomyces cerevisiae × Saccharomyces eubayanus hybrids.

    Science.gov (United States)

    Magalhães, Frederico; Krogerus, Kristoffer; Vidgren, Virve; Sandell, Mari; Gibson, Brian

    2017-08-01

    Yeast cryotolerance may be advantageous for cider making, where low temperatures are usually employed. Here, we crossed the cryotolerant S. eubayanus with a S. cerevisiae wine strain and assessed the suitability of the hybrids for low-temperature cider fermentation. All strains fermented the juice to 5% ABV, but at different rates; hybrid strains outperformed S. cerevisiae, which was sensitive to low temperatures. The best hybrid fermented similarly to S. eubayanus. S. eubayanus produced sulphurous off flavours which masked a high concentration of fruity ester notes. This phenotype was absent in the hybrid strains, resulting in distinctly fruitier ciders. Aroma was assessed by an independent consumer panel, which rated the hybrid ciders as identical to the wine strain cider. Both were significantly more pleasant than the S. eubayanus cider. Interspecific hybridization can apparently be used effectively to improve low-temperature fermentation performance without compromising product quality.

  18. Improving the physics impact of next-generation 76Ge neutrinoless double-beta decay experiments

    Energy Technology Data Exchange (ETDEWEB)

    Hossbach, Todd W. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2009-01-01

    It was shown that segmentation and pulse-shape discrimination can improve the discovery sensitivity of a next-gen 0vBB-decay experiment by 90%. - However, when practical aspects are considered (such as instrumenting each segment with front-end electronics), the discovery sensitivity is decreased by 19%. - This has extremely important consequences to proposed next-gen experiments since the two active collaborations have strongly advocated the use of segmented detectors for all or part of the experiment. - New germanium detector technology, currently under development, has demonstrated excellent multi-site background rejection capabilities without the complexity of segmentation or complicated PSD algorithms. - The physically-segmented p-type germanium detector technology has proven to be a useful and practical tool in modern nuclear physics. The PSEG technology deserves further development as it has the potential for use in a variety of applications.

  19. Methanol induces low temperature resilient methanogens and improves methane generation from domestic wastewater at low to moderate temperatures.

    Science.gov (United States)

    Saha, Shaswati; Badhe, Neha; De Vrieze, Jo; Biswas, Rima; Nandy, Tapas

    2015-01-01

    Low temperature (methanol is a preferred substrate by methanogens in cold habitats. The study hypothesizes that methanol can induce the growth of low-temperature resilient, methanol utilizing, hydrogenotrophs in UASB reactor. The hypothesis was tested in field conditions to evaluate the impact of seasonal temperature variations on methane yield in the presence and absence of methanol. Results show that 0.04% (v/v) methanol increased methane up to 15 times and its effect was more pronounced at lower temperatures. The qPCR analysis showed the presence of Methanobacteriales along with Methanosetaceae in large numbers. This indicates methanol induced the growth of both the hydrogenotrophic and acetoclastic groups through direct and indirect routes, respectively. This study thus demonstrated that methanol can impart resistance in methanogenic biomass to low temperature and can improve performance of UASB reactor.

  20. Improved Control Strategies for a DFIG-Based Wind-Power Generation System with SGSC under Unbalanced and Distorted Grid Voltage Conditions

    DEFF Research Database (Denmark)

    Yao, Jun; Yu, Mengting; Hu, Weihao

    2016-01-01

    This paper investigates an improved control strategy for a doubly-fed induction generator (DFIG) based wind-power generation system with series grid-side converter (SGSC) under network unbalance and harmonic grid voltage distortion conditions. The integrated mathematical modeling of the DFIG system...... with SGSC is established by taking both the negative-sequence and harmonic components of the grid voltages into consideration with multiple synchronous rotating reference frames. Under network unbalance and harmonic distortion situations, stator voltage can be kept symmetrical and sinusoidal by the control...... references are calculated. In addition, the allocation principles for the PGSC’s current references are proposed by taking into account the PGSC's current rating limit. The impact of PGSC’s current limit on the proposed control strategies have been investigated in detail. Furthermore, a PI regulator...

  1. Cholera: a great global concern.

    Science.gov (United States)

    Mandal, Shyamapada; Mandal, Manisha Deb; Pal, Nishith Kumar

    2011-07-01

    Cholera, caused by the infection of toxigenic Vibrio cholerae (V. cholerae) to humans, is a life threatening diarrheal disease with epidemic and pandemic potential. The V. cholerae, both O1 and O139 serogroups, produce a potent enterotoxin (cholera toxin) responsible for the lethal symptoms of the disease. The O1 serogroup has two biotypes (phenotypes), classical and El Tor; each of which has two major serotypes (based on antigenic responses), Ogawa and Inaba and the extremely rare Hikojima. V. cholerae O1 strains interconvert and switch between the Ogawa and Inaba serotypes. Fluid and electrolyte replacement is the mainstay of treatment of cholera patients; the severe cases require antibiotic treatment to reduce the duration of illness and replacement of fluid intake. The antibiotic therapy currently has faced difficulties due to the rapid emergence and spread of multidrug resistant V. cholerae causing several outbreaks in the globe. Currently, cholera has been becoming endemic in an increasing number of geographical areas, reflecting a failure in implementation of control measures. However, the current safe oral vaccines lower the number of resistant infections and could thus represent an effective intervention measure to control antibiotic resistance in cholera. Overall, the priorities for cholera control remain public health interventions through improved drinking water, sanitation, surveillance and access to health care facilities, and further development of safe, effective and appropriate vaccines. Thus, this review describes the facts and phenomena related to the disease cholera, which is still a great threat mainly to the developing countries, and hence a grave global concern too. Copyright © 2011 Hainan Medical College. Published by Elsevier B.V. All rights reserved.

  2. Application of graphene-based nanomaterials as novel cathode catalysts for improving power generation in single chamber microbial fuel cells

    Science.gov (United States)

    Valipour, Alireza; Ayyaru, Sivasankaran; Ahn, Youngho

    2016-09-01

    The low catalytic activity, limited resources, complexity and costs, and non-environmentally friendly nature are key factors limiting the application of non-precious metals and their composites at the cathode in microbial fuel cells (MFCs). This study evaluated the feasibility of graphene-based nanomaterials (RGOHI-AcOH vs. RGO/Ni nanoparticle composite) as novel cathode catalysts in single chamber air-cathode MFCs. A series of MFCs with different catalyst loadings were produced. The electrochemical behavior of the MFCs were evaluated by cyclic voltammetry (CV) and impedance spectroscopy (EIS). As a result, the MFCs with the RGOHI-AcOH cathodes showed greater maximum power densities (>37%) than those with the RGO/Ni nanoparticle cathodes. In the MFCs, the highest maximum power density of 1683 ± 23 mW/m2 (CE = 72 ± 3%), which covers 77% of that estimated for Pt/C (2201 ± 45 mW/m2, CE = 81 ± 4%), was obtained from the double loading RGOHI-AcOH cathodes. Among the MFCs with the RGO/Ni nanoparticle composite cathodes, those loaded with a double catalyst (1015 ± 28 mW/m2, CE = 70 ± 2%) showed better power performance than the others. Both CV and EIS showed good agreement with the MFC results. This study suggests that the RGOHI-AcOH cathode, particularly with a double catalyst loading, is promising for sustainable low-cost green materials, stable power generation and the long-term operation of MFCs.

  3. Transposition of the great arteries

    Directory of Open Access Journals (Sweden)

    Castela Eduardo

    2008-10-01

    Full Text Available Abstract Transposition of the great arteries (TGA, also referred to as complete transposition, is a congenital cardiac malformation characterised by atrioventricular concordance and ventriculoarterial (VA discordance. The incidence is estimated at 1 in 3,500–5,000 live births, with a male-to-female ratio 1.5 to 3.2:1. In 50% of cases, the VA discordance is an isolated finding. In 10% of cases, TGA is associated with noncardiac malformations. The association with other cardiac malformations such as ventricular septal defect (VSD and left ventricular outflow tract obstruction is frequent and dictates timing and clinical presentation, which consists of cyanosis with or without congestive heart failure. The onset and severity depend on anatomical and functional variants that influence the degree of mixing between the two circulations. If no obstructive lesions are present and there is a large VSD, cyanosis may go undetected and only be perceived during episodes of crying or agitation. In these cases, signs of congestive heart failure prevail. The exact aetiology remains unknown. Some associated risk factors (gestational diabetes mellitus, maternal exposure to rodenticides and herbicides, maternal use of antiepileptic drugs have been postulated. Mutations in growth differentiation factor-1 gene, the thyroid hormone receptor-associated protein-2 gene and the gene encoding the cryptic protein have been shown implicated in discordant VA connections, but they explain only a small minority of TGA cases. The diagnosis is confirmed by echocardiography, which also provides the morphological details required for future surgical management. Prenatal diagnosis by foetal echocardiography is possible and desirable, as it may improve the early neonatal management and reduce morbidity and mortality. Differential diagnosis includes other causes of central neonatal cyanosis. Palliative treatment with prostaglandin E1 and balloon atrial septostomy are usually

  4. Visualization of seismic tomography on Google Earth: Improvement of KML generator and its web application to accept the data file in European standard format

    Science.gov (United States)

    Yamagishi, Y.; Yanaka, H.; Tsuboi, S.

    2009-12-01

    We have developed a conversion tool for the data of seismic tomography into KML, called KML generator, and made it available on the web site (http://www.jamstec.go.jp/pacific21/google_earth). The KML generator enables us to display vertical and horizontal cross sections of the model on Google Earth in three-dimensional manner, which would be useful to understand the Earth's interior. The previous generator accepts text files of grid-point data having longitude, latitude, and seismic velocity anomaly. Each data file contains the data for each depth. Metadata, such as bibliographic reference, grid-point interval, depth, are described in other information file. We did not allow users to upload their own tomographic model to the web application, because there is not standard format to represent tomographic model. Recently European seismology research project, NEIRES (Network of Research Infrastructures for European Seismology), advocates that the data of seismic tomography should be standardized. They propose a new format based on JSON (JavaScript Object Notation), which is one of the data-interchange formats, as a standard one for the tomography. This format consists of two parts, which are metadata and grid-point data values. The JSON format seems to be powerful to handle and to analyze the tomographic model, because the structure of the format is fully defined by JavaScript objects, thus the elements are directly accessible by a script. In addition, there exist JSON libraries for several programming languages. The International Federation of Digital Seismograph Network (FDSN) adapted this format as a FDSN standard format for seismic tomographic model. There might be a possibility that this format would not only be accepted by European seismologists but also be accepted as the world standard. Therefore we improve our KML generator for seismic tomography to accept the data file having also JSON format. We also improve the web application of the generator so that the

  5. Improvement of methane generation capacity by aerobic pre-treatment of organic waste with a cellulolytic Trichoderma viride culture.

    Science.gov (United States)

    Wagner, Andreas Otto; Schwarzenauer, Thomas; Illmer, Paul

    2013-11-15

    Trichoderma viride is known as a potent cellulose decomposer and was successfully used to improve and accelerate the decomposition process of aerobic composting. In contrast, the role of fungi as pre-treatment organisms for anaerobic digestion is not clear, since the fast aerobic decomposition is thought to be responsible for a rapid depletion of easily available nutrients, leading to a lack of these for the anaerobic community. In the present study carried out in lab-scale, the application of T. viride for the aerobic pre-incubation of organic matter derived from the inlet port of a 750,000 L anaerobic digester led to an increase in total gas and methane production in a subsequent anaerobic digestion step. A high cellulase activity caused by the addition of T. viride seemed to be responsible for a better nutrient availability for anaerobic microorganisms. Therefore, aerobic pre-incubation of organic residues with T. viride for subsequent anaerobic digestion is a promising approach in order to increase methane yields.

  6. Effect of electric impulse for improved energy generation in mediatorless dual chamber microbial fuel cell through electroevolution of Escherichia coli.

    Science.gov (United States)

    Nandy, Arpita; Kumar, Vikash; Kundu, Patit P

    2016-05-15

    The main emphasis of this study is to understand the electroactive behavior of a microbe in microbial fuel cell (MFC) under specific selection pressure. This study explores potential of a non-electrogenic microbe for power production in a mediatorless MFC under the influence of a specific stress. Electric pulse of specific magnitude has been applied to Escherichia coli cells in a MFC and compared the results with unpulsed (control) MFC. Maximum power density of 187.77 mW/m(2) and 284.44 mW/m(2) for the control and experimental MFC has been observed at corresponding current density of 1444.44 mA/m(2) and 1777.77 mA/m(2). The results show improved performance for the pulsed (experimental) system, despite of initial downfall with respect to the control system. This suggests bacterial adaptation against electrical pulses which leads to evolution of an efficient electrogen. This observation is further confirmed by analyzing the results of Cyclic Voltammetry (CV), Scanning Electron Microscopy (SEM) Electrochemical Impedence Spectroscopy (EIS), enlightening different attributes like electrochemical property, bacterial morphology and impedance. The study is focused on development of a microbial fuel cell catalysed by E. coli, through triggering electroactive property in the microbe by exposing it to external stress. This study is unique in nature as it is mediatorless, economical and describes about a new method of natural bacterial evolution.

  7. The Great Cacti: Ethnobotany & Biogeography

    Directory of Open Access Journals (Sweden)

    David A. Hooper

    2010-08-01

    Full Text Available Review of The Great Cacti: Ethnobotany & Biogeography. David Yetman. 2007. The University of Arizona, Tucson. Pp. 320, 366 color photographs, 17 maps. $59.95 (cloth. ISBN 9780816524310.

  8. Juyongguan on the Great Wall

    Institute of Scientific and Technical Information of China (English)

    1999-01-01

    Juyongguan Pass on the Great Wall,one ofthe most important strategic passes of the oldcapital Beijing,is now repaired and a goodplace for tourists to see ancient Chinesemilitary and cultural facilities,as well asbeautiful local scenery.

  9. "I Climbed the Great Wall"

    Institute of Scientific and Technical Information of China (English)

    1996-01-01

    I finally climbed the Great Wall, A dream of my childhood; my heart is filled with pleasure at the indescribable beauty of the Wall. China’s ancient civilization is best documented by the grandeur of the Wall.

  10. Great Lakes Environmental Research Laboratory

    Data.gov (United States)

    Federal Laboratory Consortium — NOAA-GLERL and its partners conduct innovative research on the dynamic environments and ecosystems of the Great Lakes and coastal regions to provide information for...

  11. Great Lakes Initiative (GLI) Clearinghouse

    Data.gov (United States)

    U.S. Environmental Protection Agency — The Great Lakes Initiative Toxicity Data Clearinghouse is a central location for information on criteria, toxicity data, exposure parameters and other supporting...

  12. Improved Performance of a Wind Energy Conversion Chain Driven by an Asynchronous Generator Doubly-Fed and Using a « R-L » Filter

    Directory of Open Access Journals (Sweden)

    Aïcha Wahabi

    2015-03-01

    Full Text Available The objective of this work is the study of wind energy conversion in its entirety in order to optimize the power output, improve the quality of the energy supplied and thus make the operating point on high MPTT. For this, we are interested in modeling and simulation of a wind turbine associated with a speed multiplier, an asynchronous generator doubly-fed (DFIG and power converters interconnected via a DC bus. Then we have introduced a filter to improve the performance of the chain. We conducted the simulation and modeling of the indirect control of the DFIG. The technique adopted the algorithm is developed in Matlab/Simulink/SimPowerSystems. Simulation results are presented and analyzed at the end of this work.

  13. Dietary nitrate improves age-related hypertension and metabolic abnormalities in rats via modulation of angiotensin II receptor signaling and inhibition of superoxide generation

    DEFF Research Database (Denmark)

    Hezel, M.; Peleli, Maria; Liu, M.

    2016-01-01

    insulin responses, reduced plasma creatinine as well as improved endothelial relaxation to acetylcholine and attenuated contractility to ANG II in resistance arteries. Mechanistically, nitrate reduced NADPH oxidase-mediated oxidative stress in the cardiovascular system and increased cGMP signaling......Advanced age is associated with increased risk for cardiovascular disease and type 2 diabetes. A proposed central event is diminished amounts of nitric oxide (NO) due to reduced generation by endothelial NO synthase (eNOS) and increased oxidative stress. In addition, it is widely accepted...... glucose tolerance in aged rats, via attenuation of NADPH oxidase activity and ANG II receptor signaling. Dietary nitrate supplementation for two weeks reduced blood pressure (10–15 mmHg) and improved glucose clearance in old, but not in young rats. These favorable effects were associated with increased...

  14. The Second Generation High Speed Rotor Head Mounted Instrumentation System

    Science.gov (United States)

    Lewis, John; Reynolds, R. S. (Technical Monitor)

    1997-01-01

    NASA Ames Research Center has been investigating the air pressure flow of a rotor blade on a UH-60 Black Hawk helicopter in-flight. This paper will address the changes and improvements due to additional restrictions and requirements for the instrumentation system. The second generation instrumentation system was substantially larger and this allowed greatly improved accessibility to the components for ease of maintenance as well as improved gain and offset adjustment capabilities and better filtering.

  15. Historic Developments, Current Technologies and Potential of Nanotechnology to Develop Next Generation Solar Cells with Improved Efficiency

    Directory of Open Access Journals (Sweden)

    Nisith Raval

    2015-07-01

    Full Text Available Sun is the continuous source of renewable energy, from where we can get abundant of solar energy. Concept of conversionof solar energy into heat was used back in 200 B.C. since then, the solar cells have been developed which can convert solar energy into theelectrical energy and these systems have been produced commercially. The technologies to enhance the power conversion efficiency (PCEhave been continuously improved. Different technologies used for developing solar cells can be categorized either on the basis of materialused or techniques of technology development which is further termed as ‘first generation’ (e.g. crystalline silicon, ‘second generation’(thin films of Amorphous silicon, Copper indium gallium selenide, Cadmium telluride, ‘Third generation’ (Concentrated, Organic and Dyesensitize solar cell. These technologies give PCE up to 25% depending on the technology and the materials used. Nanotechnology enablesthe use of nanomaterial whose size is below 100 nm with extraordinary properties which has the capability to enhance the PCE to greaterextent. Various nanomaterials like Quantum Dots, Quantum well, carbon nanotubes, Nanowire and graphene have been used to makeefficient and economical solar cells, which not only provide high conversion efficiency economically but also are easy to produce. Today,by using nanotechnology, conversion efficiency up to 44.7 % has been achieved by Fraunhofer Institute at Germany. In this review article,we have reviewed the literature including various patents and publications, summarized the history of solar cell development, developmentof different technologies and rationale of their development highlighting the advantages and challenges involved in their development forcommercial purpose. We have also included the recent developments in solar cell research where different nanomaterials have beendesigned and used successfully to prove their superiority over conventional systems.

  16. Improving pharmacokinetic-pharmacodynamic modeling to investigate anti-infective chemotherapy with application to the current generation of antimalarial drugs.

    Directory of Open Access Journals (Sweden)

    Katherine Kay

    poorly reported in the malaria literature, severely reducing its value for subsequent re-application, and we make specific recommendations to improve this situation.

  17. [Improvement of sensitivity in the second generation HCV core antigen assay by a novel concentration method using polyethylene glycol (PEG)].

    Science.gov (United States)

    Higashimoto, Makiko; Takahashi, Masahiko; Jokyu, Ritsuko; Syundou, Hiromi; Saito, Hidetsugu

    2007-11-01

    A HCV core antigen (Ag) detection assay system, Lumipulse Ortho HCV Ag has been developed and is commercially available in Japan with a lower detection level limit of 50 fmol/l, which is equivalent to 20 KIU/ml in PCR quantitative assay. HCV core Ag assay has an advantage of broader dynamic range compared with PCR assay, however the sensitivity is lower than PCR. We developed a novel HCV core Ag concentration method using polyethylene glycol (PEG), which can improve the sensitivity five times better than the original assay. The reproducibility was examined by consecutive five-time measurement of HCV patients serum, in which the results of HCV core Ag original and concentrated method were 56.8 +/- 8.1 fmol/l (mean +/- SD), CV 14.2% and 322.9 +/- 45.5 fmol/l CV 14.0%, respectively. The assay results of HCV negative samples in original HCV core Ag were all 0.1 fmol/l and the results were same even in the concentration method. The results of concentration method were 5.7 times higher than original assay, which was almost equal to theoretical rate as expected. The assay results of serially diluted samples were also as same as expected data in both original and concentration assay. We confirmed that the sensitivity of HCV core Ag concentration method had almost as same sensitivity as PCR high range assay in the competitive assay study using the serially monitored samples of five HCV patients during interferon therapy. A novel concentration method using PEG in HCV core Ag assay system seems to be useful for assessing and monitoring interferon treatment for HCV.

  18. The Sixth Great Mass Extinction

    Science.gov (United States)

    Wagler, Ron

    2012-01-01

    Five past great mass extinctions have occurred during Earth's history. Humanity is currently in the midst of a sixth, human-induced great mass extinction of plant and animal life (e.g., Alroy 2008; Jackson 2008; Lewis 2006; McDaniel and Borton 2002; Rockstrom et al. 2009; Rohr et al. 2008; Steffen, Crutzen, and McNeill 2007; Thomas et al. 2004;…

  19. Improvements in tongue strength and pressure-generation precision following a tongue-pressure training protocol in older individuals with dysphagia: Three case reports

    Directory of Open Access Journals (Sweden)

    Erin M Yeates

    2008-12-01

    Full Text Available Erin M Yeates1, Sonja M Molfenter1, Catriona M Steele1,2,3,41Toronto Rehabilitation Institute, Toronto, Canada; 2Department of Speech-Language Pathology, University of Toronto, Toronto, Canada; 3Canadian Institutes of Health Research New Investigator in Aging; 4Bloorview Kids Rehab, Toronto, CanadaAbstract: Dysphagia, or difficulty swallowing, often occurs secondary to conditions such as stroke, head injury or progressive disease, many of which increase in frequency with advancing age. Sarcopenia, the gradual loss of muscle bulk and strength, can place older individuals at greater risk for dysphagia. Data are reported for three older participants in a pilot trial of a tongue-pressure training therapy. During the experimental therapy protocol, participants performed isometric strength exercises for the tongue as well as tongue pressure accuracy tasks. Biofeedback was provided using the Iowa Oral Performance Instrument (IOPI, an instrument that measures tongue pressure. Treatment outcome measures show increased isometric tongue strength, improved tongue pressure generation accuracy, improved bolus control on videofluoroscopy, and improved functional dietary intake by mouth. These preliminary results indicate that, for these three adults with dysphagia, tongue-pressure training was beneficial for improving both instrumental and functional aspects of swallowing. The experimental treatment protocol holds promise as a rehabilitative tool for various dysphagia populations.Keywords: speech-language pathology, dysphagia, rehabilitation, aging, strength, accuracy

  20. A de novo NADPH generation pathway for improving lysine production of Corynebacterium glutamicum by rational design of the coenzyme specificity of glyceraldehyde 3-phosphate dehydrogenase.

    Science.gov (United States)

    Bommareddy, Rajesh Reddy; Chen, Zhen; Rappert, Sugima; Zeng, An-Ping

    2014-09-01

    Engineering the cofactor availability is a common strategy of metabolic engineering to improve the production of many industrially important compounds. In this work, a de novo NADPH generation pathway is proposed by altering the coenzyme specificity of a native NAD-dependent glyceraldehyde 3-phosphate dehydrogenase (GAPDH) to NADP, which consequently has the potential to produce additional NADPH in the glycolytic pathway. Specifically, the coenzyme specificity of GAPDH of Corynebacterium glutamicum is systematically manipulated by rational protein design and the effect of the manipulation for cellular metabolism and lysine production is evaluated. By a combinatorial modification of four key residues within the coenzyme binding sites, different GAPDH mutants with varied coenzyme specificity were constructed. While increasing the catalytic efficiency of GAPDH towards NADP enhanced lysine production in all of the tested mutants, the most significant improvement of lysine production (~60%) was achieved with the mutant showing similar preference towards both NAD and NADP. Metabolic flux analysis with (13)C isotope studies confirmed that there was no significant change of flux towards the pentose phosphate pathway and the increased lysine yield was mainly attributed to the NADPH generated by the mutated GAPDH. The present study highlights the importance of protein engineering as a key strategy in de novo pathway design and overproduction of desired products.

  1. Improvement on counter example generation in static barrier analysis.%静态栅栏分析中反例生成的改进

    Institute of Scientific and Technical Information of China (English)

    王昭飞

    2011-01-01

    Barrier analyzers generate counter examples to help MPI programmers diagnose synchronization errors.However,existing counter example generation approaches do not support rapid error diagnosis for some real programs.This paper presents an improved counter example generation approach which records the history of MVE(Multi-Valued Expression) propagation and can infer the program inputs triggering errors. Experimental evaluation shows the proposed approach supports synchronization error diagnosis better than existing ones.%栅栏分析器生成反例以帮助MPI程序员诊断同步错误.然而,对于某些真实程序现有的反例生成方法不支持快速的错误诊断.提出了一种改进的反例生成方法.该方法记录了多值表达式的传播历史并且能够推导出触发同步错误的程序输入.实验评估表明提出的方法比现有的技术更好地支持同步错误诊断.

  2. Improvement of adaptive fuzzy control for a photovoltaic/wind/diesel generating system; Taiyoko/furyoku/diesel hatsuden system no saitekigata fuzzy seigyo no kairyo

    Energy Technology Data Exchange (ETDEWEB)

    Nagaike, H.; Kenmoku, Y.; Sakakibara, T. [Toyohashi University of Technology, Aichi (Japan); Nakagawa, S. [Maizuru National College of Technology, Kyoto (Japan); Kawamoto, T. [Shizuoka University, Shizuoka (Japan).Faculty of Engineering

    1996-10-27

    The photovoltaic/wind/diesel generating system that uses a storage battery as auxiliary power has been proposed to supply power from the system to the independent area. In this system, it is important to generate no insufficient power from the viewpoint of effective energy utilization and minimize the fuel consumption of a diesel generator. Authors have proposed the adaptive fuzzy control that changes the shape of the membership function of input variables according to the parameter indicating the system state. However, a parameter was rapidly changed in the conventional method. This badly influences the control. Therefore, the way to determine the parameter that indicates the state of this system was improved. Assume that an input value is set to the average value between a certain point of time and the {Delta}t time as the method for determining a parameter. If the {Delta}t value is lower, the change in a membership function is more effective. As a result, a greater fuel reduction effect was obtained. 4 refs., 8 figs., 1 tab.

  3. Next-generation phenotyping: requirements and strategies for enhancing our understanding of genotype-phenotype relationships and its relevance to crop improvement.

    Science.gov (United States)

    Cobb, Joshua N; Declerck, Genevieve; Greenberg, Anthony; Clark, Randy; McCouch, Susan

    2013-04-01

    More accurate and precise phenotyping strategies are necessary to empower high-resolution linkage mapping and genome-wide association studies and for training genomic selection models in plant improvement. Within this framework, the objective of modern phenotyping is to increase the accuracy, precision and throughput of phenotypic estimation at all levels of biological organization while reducing costs and minimizing labor through automation, remote sensing, improved data integration and experimental design. Much like the efforts to optimize genotyping during the 1980s and 1990s, designing effective phenotyping initiatives today requires multi-faceted collaborations between biologists, computer scientists, statisticians and engineers. Robust phenotyping systems are needed to characterize the full suite of genetic factors that contribute to quantitative phenotypic variation across cells, organs and tissues, developmental stages, years, environments, species and research programs. Next-generation phenotyping generates significantly more data than previously and requires novel data management, access and storage systems, increased use of ontologies to facilitate data integration, and new statistical tools for enhancing experimental design and extracting biologically meaningful signal from environmental and experimental noise. To ensure relevance, the implementation of efficient and informative phenotyping experiments also requires familiarity with diverse germplasm resources, population structures, and target populations of environments. Today, phenotyping is quickly emerging as the major operational bottleneck limiting the power of genetic analysis and genomic prediction. The challenge for the next generation of quantitative geneticists and plant breeders is not only to understand the genetic basis of complex trait variation, but also to use that knowledge to efficiently synthesize twenty-first century crop varieties.

  4. An Improved D-TEN Generate Algorithm and its Application in Mine Modeling%一种改进的D-TEN生成算法及其应用

    Institute of Scientific and Technical Information of China (English)

    邱佳; 李雯静; 林志勇

    2012-01-01

    First of all, the incremental insertion algorithm for Delaunay TEN generate was introduced in detailed. Then the position of the point for insertion which is the key step that affect the generate efficiency was improved by leveraging octree index and direction searching technology. And at last,the points were inserted into the tetrahedron network from both internal and external of the convex hull to handle the point insertion process. The experiment showed that the point position method not only can accelerate the Delaunay TEN generate process,but also independent of the size of the point cluster; and the approach that insertion from external of the convex hull made the insertion process more flexibility. Finally, combined with the spatial interpolation techniques, the Delaunay TEN generate method is used to the real 3D modeling of mine.%详细介绍了Delaunay TEN的生成算法——逐点插入法.利用空间八叉树索引及方向查找技术优化影响算法时间效率的关键步骤——插入点定位;结合壳内插入及壳外插入方法改进初始网格生成及加点过程.实验分析表明,点定位算法不仅能够快速对点进行定位,并且其效率与离散点规模无关;壳外插入法将插入点的位置扩展到网格外部,使初始网格的生成更加灵活.最后,结合空间插值技术,将D - TEN应用于矿床真3D建模技术中.

  5. Dietary nitrate improves age-related hypertension and metabolic abnormalities in rats via modulation of angiotensin II receptor signaling and inhibition of superoxide generation.

    Science.gov (United States)

    Hezel, Michael; Peleli, Maria; Liu, Ming; Zollbrecht, Christa; Jensen, Boye L; Checa, Antonio; Giulietti, Alessia; Wheelock, Craig E; Lundberg, Jon O; Weitzberg, Eddie; Carlström, Mattias

    2016-10-01

    Advanced age is associated with increased risk for cardiovascular disease and type 2 diabetes. A proposed central event is diminished amounts of nitric oxide (NO) due to reduced generation by endothelial NO synthase (eNOS) and increased oxidative stress. In addition, it is widely accepted that increased angiotensin II (ANG II) signaling is also implicated in the pathogenesis of endothelial dysfunction and hypertension by accelerating formation of reactive oxygen species. This study was designed to test the hypothesis that dietary nitrate supplementation could reduce blood pressure and improve glucose tolerance in aged rats, via attenuation of NADPH oxidase activity and ANG II receptor signaling. Dietary nitrate supplementation for two weeks reduced blood pressure (10-15mmHg) and improved glucose clearance in old, but not in young rats. These favorable effects were associated with increased insulin responses, reduced plasma creatinine as well as improved endothelial relaxation to acetylcholine and attenuated contractility to ANG II in resistance arteries. Mechanistically, nitrate reduced NADPH oxidase-mediated oxidative stress in the cardiovascular system and increased cGMP signaling. Finally, nitrate treatment in aged rats normalized the gene expression profile of ANG II receptors (AT1A, AT2, AT1A/AT2 ratio) in the renal and cardiovascular systems without altering plasma levels of renin or ANG II. Our results show that boosting the nitrate-nitrite-NO pathway can partly compensate for age-related disturbances in endogenous NO generation via inhibition of NADPH oxidase and modulation of ANG II receptor expression. These novel findings may have implications for nutrition-based preventive and therapeutic strategies against cardiovascular and metabolic diseases.

  6. Rural School District Reorganization on the Great Plains.

    Science.gov (United States)

    Bryant, Miles

    2002-01-01

    Rural school district reorganization and school consolidation are put into perspective by reviewing the large population increases that fueled small-school growth in the Great Plains, 1870-1930. Since the Dust Bowl and Great Depression, population losses, improvements in transportation, and arguments advocating economies of scale and increased…

  7. Trauma to the Thoracic Aorta and the Great Vessels

    Energy Technology Data Exchange (ETDEWEB)

    Hong, Min Ji; Kim, Young Tong; Jou, Sung Shick; Kim, Sang Won; Shin, Hyeong Cheol; Kim, Il Young [Soonchunhyang University Cheonan Hospital, Cheonan (Korea, Republic of)

    2009-04-15

    Trauma to the thoracic aorta and the great vessels carries a high mortality rate. The survival rate can be improved if these patients are given prompt and appropriate treatment. Various types of vascular injury are caused by blunt, penetrating, iatrogenic trauma. This article reviews the multimodality imaging of traumatic injuries to the aortic and great vessels

  8. Beach science in the Great Lakes

    Science.gov (United States)

    Nevers, Meredith B.; Byappanahalli, Murulee N.; Edge, Thomas A.; Whitman, Richard L.

    2014-01-01

    Monitoring beach waters for human health has led to an increase and evolution of science in the Great Lakes, which includes microbiology, limnology, hydrology, meteorology, epidemiology, and metagenomics, among others. In recent years, concerns over the accuracy of water quality standards at protecting human health have led to a significant interest in understanding the risk associated with water contact in both freshwater and marine environments. Historically, surface waters have been monitored for fecal indicator bacteria (fecal coliforms, Escherichia coli, enterococci), but shortcomings of the analytical test (lengthy assay) have resulted in a re-focusing of scientific efforts to improve public health protection. Research has led to the discovery of widespread populations of fecal indicator bacteria present in natural habitats such as soils, beach sand, and stranded algae. Microbial source tracking has been used to identify the source of these bacteria and subsequently assess their impact on human health. As a result of many findings, attempts have been made to improve monitoring efficiency and efficacy with the use of empirical predictive models and molecular rapid tests. All along, beach managers have actively incorporated new findings into their monitoring programs. With the abundance of research conducted and information gained over the last 25 years, “Beach Science” has emerged, and the Great Lakes have been a focal point for much of the ground-breaking work. Here, we review the accumulated research on microbiological water quality of Great Lakes beaches and provide a historic context to the collaborative efforts that have advanced this emerging science.

  9. Great improvement of photoelectric property from co-sensitization of TiO{sub 2} electrodes with CdS quantum dots and dye N719 in dye-sensitized solar cells

    Energy Technology Data Exchange (ETDEWEB)

    Li, Jing [Ministry-of-Education, Key Laboratory for the Green Preparation and Application of Functional Materials, Faculty of Materials Science and Engineering, Hubei University, Wuhan 430062 (China); Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials, Wuhan 430062 (China); Zhao, Li, E-mail: zhaoli7376@163.com [Ministry-of-Education, Key Laboratory for the Green Preparation and Application of Functional Materials, Faculty of Materials Science and Engineering, Hubei University, Wuhan 430062 (China); Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials, Wuhan 430062 (China); Wang, Shimin, E-mail: shiminwang@126.com [Ministry-of-Education, Key Laboratory for the Green Preparation and Application of Functional Materials, Faculty of Materials Science and Engineering, Hubei University, Wuhan 430062 (China); Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials, Wuhan 430062 (China); Hu, Jinghua [School of Science, Wuhan University of Technology, Wuhan 430070 (China); Dong, Binghai; Lu, Hongbing; Wan, Li [Ministry-of-Education, Key Laboratory for the Green Preparation and Application of Functional Materials, Faculty of Materials Science and Engineering, Hubei University, Wuhan 430062 (China); Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials, Wuhan 430062 (China); Wang, Ping [School of Science, Wuhan University of Technology, Wuhan 430070 (China)

    2013-07-15

    Graphical abstract: - Highlights: • TiO{sub 2} film electrodes have been successfully sensitized with CdS QDs. • DSSC based on CdS QDs-sensitized TiO{sub 2} film with 4 min has the highest efficiency. • CdS QDs can improve the electron transport and reduce the electron recombination. • Our work open up a new avenue for the development of DSSCs. - Abstract: The TiO{sub 2} film electrodes sensitized with CdS quantum dots (QDs) via chemical bath deposition method were successfully prepared as the photoanode of dye-sensitized solar cells (DSSCs). Microstructural characterizations by XRD, SEM, TEM and EDX show that the CdS nanocrystals with the cubic structure have intimate contact to the TiO{sub 2} films. The amount of CdS QDs can be controlled by varying the dipping time. The experiment results demonstrate that the CdS QDs-sensitized solar cells show a wider absorption in the solar spectrum and an enhanced surface photovoltage response. The maximal photoelectric conversion efficiency of 5.57% was achieved by the DSSC based on CdS QDs-sensitized TiO{sub 2} film with 4 min. The performance improvement is ascribed to the enhancement of electron transport, the reduction of electron recombination and the long electron lifetime.

  10. Fitzgerald and The Great Gatsby

    Institute of Scientific and Technical Information of China (English)

    王利娟

    2014-01-01

    F. Scott Fitzgerald, the famous American novelist in the 1920s, is famous as the spokesman and laureate of the“The Lost Generation”. Considered one of Fitzgerald’s representative works and the finest achievement of his literary career, The Great Gatsby is widely recognized as a classic of American literature. Since its publication in 1925, it has been a continual hot sub⁃ject of critical attention,and studies on it have never stopped. This paper provides a detailed account of“the Fitzgerald revival”as well as the previous criticism on The Great Gatsby.

  11. Famous puzzles of great mathematicians

    CERN Document Server

    Petković, Miodrag S

    2009-01-01

    This entertaining book presents a collection of 180 famous mathematical puzzles and intriguing elementary problems that great mathematicians have posed, discussed, and/or solved. The selected problems do not require advanced mathematics, making this book accessible to a variety of readers. Mathematical recreations offer a rich playground for both amateur and professional mathematicians. Believing that creative stimuli and aesthetic considerations are closely related, great mathematicians from ancient times to the present have always taken an interest in puzzles and diversions. The goal of this

  12. Healthy Family 2009: 8 Great "Whys" Seniors Should Exercise

    Science.gov (United States)

    ... Current Issue Past Issues Healthy Family 2009 8 Great "Whys" Seniors Should Exercise Past Issues / Winter 2009 ... strength—carry groceries, climb stairs Improve balance—prevent falls Restore flexibility—speed recovery from injury Build endurance— ...

  13. Building unique surface structure on aramid fibers through a green layer-by-layer self-assembly technique to develop new high performance fibers with greatly improved surface activity, thermal resistance, mechanical properties and UV resistance

    Science.gov (United States)

    Zhou, Lifang; Yuan, Li; Guan, Qingbao; Gu, Aijuan; Liang, Guozheng

    2017-07-01

    Combining green preparation and high performance is becoming the direction of sustainable development of materials. How to simultaneously overcome the two bottlenecks (poor surface activity and UV resistance) of aramid fibers (AFs) while improving thermal and mechanical properties through a green process is still an interesting issue with big challenge. Herein, new AFs (BL-AFs) were prepared by alternately self-assembling SiO2 and MgAlFe layered double hydroxide (LDH) on surfaces of AFs, successively, through a green layer-by-layer (LBL) self-assembly technique without using high temperature and organic solvent. The structures and properties of BL-AFs were systematically studied, which are controllable by adjusting the number of self-assembly cycle. The new fibers with three or more self-assembly cycles have remarkably improved surface activity, thermal resistance, mechanical properties and UV resistance compared with AFs. Typically, with three self-assembly cycles, the initial degradation temperature and char yield of the new fiber (3BL-AF) are as high as 552.9 °C and 81.2%, about 92 °C and 25.2% higher than those of AF, respectively; after 168 h-UV irradiation, the retention of tensile performances of 3BL-AF fiber is as high as 91-95%, about 29-14% higher than that of AF, showing the best overall performances among all modified AFs prepared using a green technique reported so far. The origin behind the attractive performances of BL-AFs is revealed through correlating with structures of original and modified fibers. The excellent comprehensive properties of BL-AFs demonstrate that the green method provided in this study is facile and effective to completely solve the bottlenecks of aramid fibers, and developing higher performance organic fibers.

  14. Meteotsunamis in the Laurentian Great Lakes

    Science.gov (United States)

    Bechle, Adam J.; Wu, Chin H.; Kristovich, David A. R.; Anderson, Eric J.; Schwab, David J.; Rabinovich, Alexander B.

    2016-11-01

    The generation mechanism of meteotsunamis, which are meteorologically induced water waves with spatial/temporal characteristics and behavior similar to seismic tsunamis, is poorly understood. We quantify meteotsunamis in terms of seasonality, causes, and occurrence frequency through the analysis of long-term water level records in the Laurentian Great Lakes. The majority of the observed meteotsunamis happen from late-spring to mid-summer and are associated primarily with convective storms. Meteotsunami events of potentially dangerous magnitude (height > 0.3 m) occur an average of 106 times per year throughout the region. These results reveal that meteotsunamis are much more frequent than follow from historic anecdotal reports. Future climate scenarios over the United States show a likely increase in the number of days favorable to severe convective storm formation over the Great Lakes, particularly in the spring season. This would suggest that the convectively associated meteotsunamis in these regions may experience an increase in occurrence frequency or a temporal shift in occurrence to earlier in the warm season. To date, meteotsunamis in the area of the Great Lakes have been an overlooked hazard.

  15. Improved method for methane generation

    DEFF Research Database (Denmark)

    2010-01-01

    A method for treatment of a material comprising lignocellulosic fibres is disclosed. More particularly, the treatment increases the accessibility of the lignocellulosic fibres for following microbial or biological processes....

  16. Renegotiation of the 1987 Great Lakes Water Quality Agreement: From Confusion to Promise

    Directory of Open Access Journals (Sweden)

    Gail Krantzberg

    2012-06-01

    Full Text Available For nearly four decades, the Great Lakes regime has invoked the Great Lakes Water Quality Agreement as the mechanism for binational cooperation on programs and policies. Many advances in water quality have led to unquestionable improvements in ecosystem quality, habitat and biodiversity, and water infrastructure. Still, Great Lakes scientists have issued compelling evidence that the ecological health of the basin ecosystem is at significant risk. In 2012, the Agreement will be revised for the first time in 25 years. The degree of engagement in a future Agreement, including scope, issues of significant importance, governance and collaboration will hinge on a thorough analytical process, so far seemingly absent, coupled with real consultation, so far marginally evident. Renegotiating the Agreement to generate a revitalized and sustainable future mandates that science inform contemporary public policy, and that inclusive discourse and public engagement be integral through the process. Many of these steps are still absent, and the analysis presented here strongly suggests that the constituents of the Great Lakes regime voice their views critically, emphatically, and often. If the negotiators listen, we can collectively make the Lakes Great.

  17. The Great Principles of Computing

    OpenAIRE

    2010-01-01

    The article of record as published may be found at http://dx.doi.org/The article of record as published may be found at http://dx.doi.org/10.1145/948383.948400 American Scientist,. Computing may be the fourth great domain of science, along with the physical, life, and social sciences.

  18. The Great Gatsby. [Lesson Plan].

    Science.gov (United States)

    Zelasko, Ken

    Based on F. Scott Fitzgerald's novel "The Great Gatsby," this lesson plan presents activities designed to help students understand that adapting part of a novel into a dramatic reading makes students more intimate with the author's intentions and craft; and that a part of a novel may lend itself to various oral interpretations. The main activity…

  19. Myths of the Great War

    OpenAIRE

    Harrison, Mark

    2014-01-01

    We review some "myths" of the Great War of 1914 to 1918: that the war broke out inadvertently, that the western front saw needless slaughter, that the Allies used the food weapon to strangle Germany, and that the peace treaty that ended the war caused the rise of Hitler and the still greater war that followed.\\ud

  20. Great Lakes' regional climate regimes

    Science.gov (United States)

    Kravtsov, Sergey; Sugiyama, Noriyuki; Roebber, Paul

    2016-04-01

    We simulate the seasonal cycle of the Great Lakes' water temperature and lake ice using an idealized coupled lake-atmosphere-ice model. Under identical seasonally varying boundary conditions, this model exhibits more than one seasonally varying equilibrium solutions, which we associate with distinct regional climate regimes. Colder/warmer regimes are characterized by abundant/scarce amounts of wintertime ice and cooler/warmer summer temperatures, respectively. These regimes are also evident in the observations of the Great Lakes' climate variability over recent few decades, and are found to be most pronounced for Lake Superior, the deepest of the Great Lakes, consistent with model predictions. Multiple climate regimes of the Great Lakes also play a crucial role in the accelerated warming of the lakes relative to the surrounding land regions in response to larger-scale global warming. We discuss the physical origin and characteristics of multiple climate regimes over the lakes, as well as their implications for a longer-term regional climate variability.

  1. The Great Bug Hunt 2011

    Science.gov (United States)

    Dixon-Watmough, Rebecca

    2011-01-01

    The Association For Science Education's "schoolscience.co.uk Great Bug Hunt 2011," in association with Martin Rapley and Gatekeeper Educational, has been a resounding success--not only because it fits into the science curriculum so neatly, but also because of the passion it evoked in the children who took part. This year's entries were…

  2. The Great Goddesses of Egypt

    Institute of Scientific and Technical Information of China (English)

    SheldonGosline; KatjaReinhardt; NortheastNormalUniversity

    2000-01-01

    Norman,Oklahoma:UniversityofOklahomaPress:Norman,1999.ISBN0-8061-3202-7.Pp.319.US$19.95.TheGreatGoddessesofEgyptstelltsiebenGoettinnenindenMittelpunktderagyptischenReligionsgeschichte:Nut,Neith,Nechbet,Wadjet,Hathor,MutundIsis.JederGottinisteineigenesKapitelgewidmet,zusatzlichsindeineEinfuhrung,diesichkurzmitderFnihdynastischenZeitbeschaftigt,undeinKapitelzuTempelundKultbeigefugt.EinGlossar,dasGottinnen(keineGotter)undeinigeimTexterwahnteKoniginnenauffuhrt,undeineausfuhrlicheBibliographieschlierendasBuchab....

  3. Symbols in the Great Gatsby

    Institute of Scientific and Technical Information of China (English)

    徐琰

    2016-01-01

    This paper analyzes the symbols in the book"The Great Gatsby" which include some particular places, objects, characters, settings and actions. These symbols are considered to have values different from what they are symbolized and most of them are connected to the theme of the novel-the corruption of the American dream.

  4. The Great War. [Teaching Materials].

    Science.gov (United States)

    Public Broadcasting Service, Washington, DC.

    This package of teaching materials is intended to accompany an eight-part film series entitled "The Great War" (i.e., World War I), produced for public television. The package consists of a "teacher's guide,""video segment index,""student resource" materials, and approximately 40 large photographs. The video series is not a war story of battles,…

  5. Great Expectations and New Beginnings

    Science.gov (United States)

    Davis, Frances A.

    2009-01-01

    Great Expectation and New Beginnings is a prenatal family support program run by the Family, Infant, and Preschool Program (FIPP) in North Carolina. FIPP has developed an evidence-based integrated framework of early childhood intervention and family support that includes three primary components: providing intervention in everyday family…

  6. Some features of generation of spoke-shaped neodyminum lasers

    Energy Technology Data Exchange (ETDEWEB)

    Dzhibladze, M.I.; Lazarev, L.E.

    1982-08-01

    Experimental results are presented on the generation properties of spoke-shaped neodymium lasers in the periodic giant pulse regime. In lasers with polished end-faces, two types of pulses were observed, corresponding to longitudinal and circular types of oscillation. It is shown that the energetic characteristics of generation in spoke-shaped neodymium lasers improve greatly when circular types of oscillation are suppressed.

  7. Studies of the generation mechanisms of steady vortex formations in the channels of nuclear-power installations for purposes of improving the reliability and safety of their work

    Science.gov (United States)

    Mitrofanova, O.

    2017-01-01

    The analysis of the results of experimental researches on revealing the mechanisms of vortex formation in channels of complex geometry in the neutral and conductive media is carried out. The directions of researches related to the study of mechanisms of vortex generation and accumulation of energy by large-scale vortex structures are considered for the possibility of predictions of the man-made accidents and catastrophic natural phenomena. The main goal of ongoing investigations is the solution of the task aimed at improving the safety of nuclear power installations and, in particular, of the fast neutron reactors with liquid-metal coolants, and the prevention of emergency modes arising from acoustic, magnetic and hydrodynamic resonance effects.

  8. Comparison of Harmony Search Algorithm and Particle Swarm Optimization for Distributed Generation Allocation to Improve Steady State Voltage Stability of Distribution Networks

    Directory of Open Access Journals (Sweden)

    Hamed Piarehzadeh

    2012-08-01

    Full Text Available In this study is tried to optimal distributed generation allocation for stability improvement in radial distribution systems. Voltage instability implies an uncontrolled decrease in voltage triggered by a disturbance, leading to voltage collapse and is primarily caused by dynamics connected with the load. The instability is divided into steady state and transient voltage instability Based on the time spectrum of the incident of the phenomena. The analysis is accomplished using a steady state voltage stability index which can be evaluated at each node of the distribution system. Several optimal capacities and locations are used to check these results. The location of DG has the main effect voltage stability on the system. Effects of location and capacity on incrementing steady state voltage stability in radial distribution systems are examined through Harmony Search Algorithm (HSA and finally the results are compared to Particle Swarm Optimization (PSO on the terms of speed, convergence and accuracy.

  9. Improved methods for the generation of 24.5 keV neutron beams with possible application to boron neutron capture therapy

    Science.gov (United States)

    Constantine, G.; Baker, L. J.; Taylor, N. P.

    1986-09-01

    The production of epithermal neutron beams, filtered to provide a spectrum in which a small energy range predominates, is of importance for radiobiological research and in the development and calibration of instruments for monitoring intermediate energy neutrons. The penetration characteristics of intermediate energy neutrons in tissue lead to the possibility of application in the field of neutron capture therapy if beams of sufficient intensity and adequate spectral properties can be generated. In this paper methods of utilising the 24.5 keV antiresonance in the iron neutron cross section are described, and the DENIS (depth enhanced neutron intense source) principle by which beam intensities may be optimised is explained. Calculations and experimental measurements in an in-core facility in the DIDO reactor at Harwell have indicated that a DENIS scatterer can achieve a 6-fold improvement in 24.5 keV beam intensity compared with a conventional titanium disc scatterer.

  10. Simulation Research of Photovoltaic Power Generation System Based on Improved MPPT%基于改进MPPT的光伏发电系统仿真研究

    Institute of Scientific and Technical Information of China (English)

    刘立立; 林永君; 刘卫亮

    2016-01-01

    光伏发电系统中,对电源的输出功率进行最大功率点跟踪( MPPT)是极其重要的。为了提高光伏电池的发电效率,提出了一种改进的扰动观察法进行最大功率跟踪,不仅能很快很准地跟踪最大功率,而且能使系统的稳定性得到保持。通过对逆变器的控制策略进行研究,提出了一种双闭环控制方式,能够保持输出电压稳定,满足微网孤岛运行要求。通过仿真结果,可以看出该方法的有效性与可行性。%In photovoltaic power generation system, the maximum power point tracking ( MPPT) is very important for power supply. In order to improve the power generation efficiency of the photovoltaic cells, an improved disturb-ance observer method is proposed for maximum power tracking, This method can not only quickly tracking the max-imum power with good accuracy, but aslo maintain the stability of the system. Based on the control strategy of in-verter, a double closed loop control method is proposed, which can keep the output voltage stable and meet the re-quirements of micro grid operation. The validity and feasibility of the method is verified by the simulation results.

  11. Next-generation repeat-free FISH probes for DNA amplification in glioblastoma in vivo: Improving patient selection to MDM2-targeted inhibitors.

    Science.gov (United States)

    Brunelli, Matteo; Eccher, Albino; Cima, Luca; Trippini, Tobia; Pedron, Serena; Chilosi, Marco; Barbareschi, Mattia; Scarpa, Aldo; Pinna, Giampietro; Cabrini, Giulio; Pilotto, Sara; Carbognin, Luisa; Bria, Emilio; Tortora, Giampaolo; Fioravanzo, Adele; Schiavo, Nicola; Meglio, Mario; Sava, Teodoro; Belli, Laura; Martignoni, Guido; Ghimenton, Claudio

    2017-01-01

    A next-generation FISH probe mapping to the MDM2 locus-specific region has recently been designed. The level of MDM2 gene amplification (high versus low) may allow selection of patients for cancer treatment with MDM2 inhibitors and may predict their responsiveness. We investigated the spectrum of MDM2 gene alterations using the new probes in vivo after visualizing single neoplastic cells in situ from a series of glioblastomas. Signals from next-generation repeat-free FISH interphase probes were identified in tissue microarrays that included 3 spots for each of the 48 cases. The murine double minutes (MDM2)-specific DNA probe and the satellite enumeration probe for chromosome 12 were used. Three cases (6%) showed more than 25 signals (high gene amplification), and 7 (15%) showed 3-10 signals (gains); among these, 4 cases (8%) had an equal number of MDM2 and centromeric signals on chromosome 12 (polyploidy). Genomic heterogeneity was observed only in 3 cases with low gene amplification. In our series, 6% of glioblastomas exhibited high MDM2 amplification (in vivo) with a pattern related to the known double minutes/chromothripsis phenomenon (in situ), and only cases with low amplification showed genomic heterogeneity. We concluded that the rate of MDM2 gene amplification can be a useful predictive biomarker to improve patient selection.

  12. Improved Methods to Generate Spheroid Cultures from Tumor Cells, Tumor Cells & Fibroblasts or Tumor-Fragments: Microenvironment, Microvesicles and MiRNA.

    Directory of Open Access Journals (Sweden)

    Zheng Lao

    Full Text Available Diagnostic and prognostic indicators are key components to achieve the goal of personalized cancer therapy. Two distinct approaches to this goal include predicting response by genetic analysis and direct testing of possible therapies using cultures derived from biopsy specimens. Optimally, the latter method requires a rapid assessment, but growing xenograft tumors or developing patient-derived cell lines can involve a great deal of time and expense. Furthermore, tumor cells have much different responses when grown in 2D versus 3D tissue environments. Using a modification of existing methods, we show that it is possible to make tumor-fragment (TF spheroids in only 2-3 days. TF spheroids appear to closely model characteristics of the original tumor and may be used to assess critical therapy-modulating features of the microenvironment such as hypoxia. A similar method allows the reproducible development of spheroids from mixed tumor cells and fibroblasts (mixed-cell spheroids. Prior literature reports have shown highly variable development and properties of mixed-cell spheroids and this has hampered the detailed study of how individual tumor-cell components interact. In this study, we illustrate this approach and describe similarities and differences using two tumor models (U87 glioma and SQ20B squamous-cell carcinoma with supporting data from additional cell lines. We show that U87 and SQ20B spheroids predict a key microenvironmental factor in tumors (hypoxia and that SQ20B cells and spheroids generate similar numbers of microvesicles. We also present pilot data for miRNA expression under conditions of cells, tumors, and TF spheroids.

  13. Why greatness cannot be planned the myth of the objective

    CERN Document Server

    Stanley, Kenneth O

    2015-01-01

    Why does modern life revolve around objectives? From how science is funded, to improving how children are educated -- and nearly everything in-between -- our society has become obsessed with a seductive illusion: that greatness results from doggedly measuring improvement in the relentless pursuit of an ambitious goal. In Why Greatness Cannot Be Planned, Stanley and Lehman begin with a surprising scientific discovery in artificial intelligence that leads ultimately to the conclusion that the objective obsession has gone too far. They make the case that great achievement can't be bottled up int

  14. The Great Adventure of an American Human Geneticist.

    Science.gov (United States)

    Motulsky, Arno G; King, Mary-Claire

    2016-08-31

    It is my great pleasure to have been asked by the Editorial Committee of the Annual Review of Genomics and Human Genetics to write a short autobiography of my life in genetics over the past 70 years. It has been a great adventure. I came both to America and to human genetics by a circuitous and ultimately very fortunate route. I hope the next generation of geneticists will enjoy reading about it.

  15. 基于改进遗传算法的智能组卷研究%An Intelligent Generating Examination Paper Method Based on Improved Genetic Algorithm

    Institute of Scientific and Technical Information of China (English)

    许永达

    2013-01-01

    因为传统组卷方法的时间和空间开销大、成功率较低,简单遗传算法的收敛速度慢、稳定性差,所以提出了基于改进遗传算法的智能组卷方法,通过根据个体适应度值自适应地选择个体,调整交叉概率和变异概率等措施,加快了算法向最优解的逼近速度,提高了组卷的效率和成功率.论文介绍了该组卷方法的组卷策略,数学模型,各模块的详细设计.%The traditional Generating Examination Paper method has disadvantages of large time and space consumption, and low success rate. The simple generic algorithm has disadvantages of slow convergence speed and poor stability. So an intelligent test construction method based on improved generic algorithm is proposed. The intelligent method adaptivety selects individuals and adjusts the crossover and mutation probabilities based on individual fitness, which accelerates approximation speed to the optimal solution and improves the efficiency and success rate. This paper will introduce the test construction strategies, mathematical model, and the detailed design of each module.

  16. Photocatalytic hydrogen generation enhanced by band gap narrowing and improved charge carrier mobility in AgTaO3 by compensated co-doping.

    Science.gov (United States)

    Li, Min; Zhang, Junying; Dang, Wenqiang; Cushing, Scott K; Guo, Dong; Wu, Nianqiang; Yin, Penggang

    2013-10-14

    The correlation of the electronic band structure with the photocatalytic activity of AgTaO3 has been studied by simulation and experiments. Doping wide band gap oxide semiconductors usually introduces discrete mid-gap states, which extends the light absorption but has limited benefit for photocatalytic activity. Density functional theory (DFT) calculations show that compensated co-doping in AgTaO3 can overcome this problem by increasing the light absorption and simultaneously improving the charge carrier mobility. N/H and N/F co-doping can delocalize the discrete mid-gap states created by sole N doping in AgTaO3, which increases the band curvature and the electron-to-hole effective mass ratio. In particular, N/F co-doping creates a continuum of states that extend the valence band of AgTaO3. N/F co-doping thus improves the light absorption without creating the mid-gap states, maintaining the necessary redox potentials for water splitting and preventing from charge carrier trapping. The experimental results have confirmed that the N/F-codoped AgTaO3 exhibits a red-shift of the absorption edge in comparison with the undoped AgTaO3, leading to remarkable enhancement of photocatalytic activity toward hydrogen generation from water.

  17. Transplantation of human spleen into immunodeficient NOD/SCID IL2Rγ(null) mice generates humanized mice that improve functional B cell development.

    Science.gov (United States)

    Chung, Yun Shin; Son, Jin Kyung; Choi, Bongkum; Park, Jae Berm; Chang, Jun; Kim, Sung Joo

    2015-12-01

    We previously generated humanized TB34N mice that received human fetal thymus (T), bone tissue (B) and fetal liver-derived (FL)-CD34(+) cells (34) in immunodeficient, NOD/SCID IL2Rγ(null) (N) mice. Although humanized TB34N mice had excellent hematopoiesis, here, we sought to further improve this model by additional transplantation of human spleen tissue (S) as a secondary hematopoietic tissue (TBS34N). The human spleen grafts were enlarged and differentiated into a similar morphology of adult humans, including follicular lymphoid structures with T- and B-cells. The TBS34N mice mimicked mature human immune system (HIS): mature T- and B-cells and follicular dendritic cells; activated germinal center B-cells expressing CD71, BR3(+) cells, memory B-cells and activation-induced cytidine deaminase(+) B-cells; CD138(+) plasma cells were enriched in the mouse spleen. HBsAg-specific hIgG antibodies were secreted into the sera of all TBS34N mice upon immunization with HBsAg. Taken together, the humanized TBS34N mice improved mature HIS and achieved adaptive antibody responses.

  18. Novel gaseous transient species: generation and characterization

    Institute of Scientific and Technical Information of China (English)

    ZENG XiaoQing; WANG DianXun

    2007-01-01

    Due to special properties of transient species, such as short-lived, unstable, reactive, and even explosive, the generation and subsequent characterization is a great challenge for experimental chemists. In our laboratory, systematic researches have been carried out to investigate novel transient species:reactive halogen species (RHS), short-lived free radicals, and metastable pseudohalogen compounds,based on the successive technical improvements on the Hel Photoelectron spectroscopy (PES). In this review, the topic mainly focuses on innovative methods of generating novel transient species, and subsequent geometric and electronic structure characterizations of these species combined with quantum chemical calculations.

  19. Improvement of thermal conductivity of ceramic matrix composites for 4. generation nuclear reactors; Amelioration de la conductivite thermique des composites a matrice ceramique pour les reacteurs de 4. generation

    Energy Technology Data Exchange (ETDEWEB)

    Cabrero, J.

    2009-11-15

    This study deals with thermal conductivity improvement of SiCf/SiC ceramic matrix composites materials to be used as cladding material in 4. generation nuclear reactor. The purpose of the study is to develop a composite for which both the temperature and irradiation effect is less pronounced on thermal conductivity of material than for SiC. This material will be used as matrix in CMC with SiC fibers. Some TiC-SiC composites with different SiC volume contents were prepared by spark plasma sintering (SPS). The sintering process enables to fabricate specimens very fast, with a very fine microstructure and without any sintering aids. Neutron irradiation has been simulated using heavy ions, at room temperature and at 500 C. Evolution of the thermal properties of irradiated materials is measured using modulated photothermal IR radiometry experiment and was related to structural evolution as function of dose and temperature. It appears that such approach is reliable to evaluate TiC potentiality as matrix in CMC. Finally, CMC with TiC matrix and SiC fibers were fabricated and both mechanical and thermal properties were measured and compare to SiCf/SiC CMC. (author)

  20. Improving Adequacy of Small Biopsy and Fine-Needle Aspiration Specimens for Molecular Testing by Next-Generation Sequencing in Patients With Lung Cancer: A Quality Improvement Study at Dartmouth-Hitchcock Medical Center.

    Science.gov (United States)

    Padmanabhan, Vijayalakshmi; Steinmetz, Heather B; Rizzo, Elizabeth J; Erskine, Amber J; Fairbank, Tamara L; de Abreu, Francine B; Tsongalis, Gregory J; Tafe, Laura J

    2017-03-01

    - At our medical center, cytopathologists perform rapid on-site evaluation for specimen adequacy of fine-needle aspiration and touch imprint of needle core biopsy lung cancer samples. Two years ago the molecular diagnostics laboratory at our institution changed to next-generation sequencing using the Ion Torrent PGM and the 50-gene AmpliSeq Cancer Hotspot Panel v2 for analyzing mutations in a 50-gene cancer hot spot panel. This was associated with a dramatic fall in adequacy rate (68%). - To improve the adequacy rate to at least 90% for molecular testing using next-generation sequencing for all specimens collected by rapid on-site evaluation by the cytology laboratory. - After baseline data on adequacy rate of cytology specimens with rapid on-site evaluation for molecular testing had been collected, 2 changes were implemented. Change 1 concentrated all the material in one block but did not produce desired results; change 2, in addition, faced the block only once with unstained slides cut up front for molecular testing. Data were collected in an Excel spreadsheet and adequacy rate was assessed. - Following process changes 1 and 2 we reached our goal of at least 90% adequacy rate for molecular testing by next-generation sequencing on samples collected by rapid on-site evaluation including computed tomography-guided needle core biopsies (94%; 17 of 18) and fine-needle aspiration samples (94%; 30 of 32). - This study focused on factors that are controllable in a pathology department and on maximizing use of scant tissue. Optimizing the adequacy of the specimen available for molecular tests avoids the need for a second procedure to obtain additional tissue.

  1. Ohlin on the Great Depression

    OpenAIRE

    Carlson, Benny; Jonung, Lars

    2013-01-01

    Bertil Ohlin was a most active commentator on current economic events in the interwar period, combining his academic work with a journalistic output of an impressive scale. He published more than a thousand newspaper articles in the 1920s and 1930s, more than any other professor in economics in Sweden. Here we have collected ten articles by Ohlin, translated from Swedish and originally published in Stockholms-Tidningen, to trace the evolution of his thinking during the Great Depression of the...

  2. Southern Great Plains Safety Orientation

    Energy Technology Data Exchange (ETDEWEB)

    Schatz, John

    2014-05-01

    Welcome to the Atmospheric Radiation Measurement (ARM) Climate Research Facility (ARM) Southern Great Plains (SGP) site. This U.S. Department of Energy (DOE) site is managed by Argonne National Laboratory (ANL). It is very important that all visitors comply with all DOE and ANL safety requirements, as well as those of the Occupational Safety and Health Administration (OSHA), the National Fire Protection Association, and the U.S. Environmental Protection Agency, and with other requirements as applicable.

  3. Improvement of Sodium Neutronic Nuclear Data for the Computation of Generation IV Reactors; Contribution a l'amelioration des donnees nucleaires neutroniques du sodium pour le calcul des reacteurs de generation IV

    Energy Technology Data Exchange (ETDEWEB)

    Archier, P.

    2011-09-14

    The safety criteria to be met for Generation IV sodium fast reactors (SFR) require reduced and mastered uncertainties on neutronic quantities of interest. Part of these uncertainties come from nuclear data and, in the particular case of SFR, from sodium nuclear data, which show significant differences between available international libraries (JEFF-3.1.1, ENDF/B-VII.0, JENDL-4.0). The objective of this work is to improve the knowledge on sodium nuclear data for a better calculation of SFR neutronic parameters and reliable associated uncertainties. After an overview of existing {sup 23}Na data, the impact of the differences is quantified, particularly on sodium void reactivity effects, with both deterministic and stochastic neutronic codes. Results show that it is necessary to completely re-evaluate sodium nuclear data. Several developments have been made in the evaluation code Conrad, to integrate new nuclear reactions models and their associated parameters and to perform adjustments with integral measurements. Following these developments, the analysis of differential data and the experimental uncertainties propagation have been performed with Conrad. The resolved resonances range has been extended up to 2 MeV and the continuum range begins directly beyond this energy. A new {sup 23}Na evaluation and the associated multigroup covariances matrices were generated for future uncertainties calculations. The last part of this work focuses on the sodium void integral data feedback, using methods of integral data assimilation to reduce the uncertainties on sodium cross sections. This work ends with uncertainty calculations for industrial-like SFR, which show an improved prediction of their neutronic parameters with the new evaluation. (author) [French] Les criteres de surete exiges pour les reacteurs rapides au sodium de Generation IV (RNR-Na) se traduisent par la necessite d'incertitudes reduites et maitrisees sur les grandeurs neutroniques d'interet. Une part

  4. Great Basin geoscience data base

    Science.gov (United States)

    Raines, Gary L.; Sawatzky, Don L.; Connors, Katherine A.

    1996-01-01

    This CD-ROM serves as the archive for 73 digital GIS data set for the Great Basin. The data sets cover Nevada, eastern California, southeastern Oregon, southern Idaho, and western Utah. Some of the data sets are incomplete for the total area. On the CD-ROM, the data are provided in three formats, a prototype Federal Data Exchange standard format, the ESRI PC ARCVIEW1 format for viewing the data, and the ESRI ARC/INFO export format. Extensive documentation is provided to describe the data, the sources, and data enhancements. The following data are provided. One group of coverages comes primarily from 1:2,000,000-scale National Atlas data and can be assembled for use as base maps. These various forms of topographic information. In addition, public land system data sets are provided from the 1:2,500,000-scale Geologic Map of the United States and 1:500,000-scale geologic maps of Nevada, Oregon, and Utah. Geochemical data from the National Uranium Resource Evaluation (NURE) program are provided for most of the Great Basin. Geophysical data are provided for most of the Great Basin, typically gridded data with a spacing of 1 km. The geophysical data sets include aeromagnetics, gravity, radiometric data, and several derivative products. The thematic data sets include geochronology, calderas, pluvial lakes, tectonic extension domains, distribution of pre-Cenozoic terranes, limonite anomalies, Landsat linear features, mineral sites, and Bureau of Land Management exploration and mining permits.

  5. A five-year performance review of field-scale, slow-release permanganate candles with recommendations for second-generation improvements.

    Science.gov (United States)

    Christenson, Mark; Kambhu, Ann; Reece, James; Comfort, Steve; Brunner, Laurie

    2016-05-01

    In 2009, we identified a TCE plume at an abandoned landfill that was located in a low permeable silty-clay aquifer. To treat the TCE, we manufactured slow-release potassium permanganate cylinders (oxidant candles) that had diameters of either 5.1 or 7.6 cm and were 91.4 cm long. In 2010, we compared two methods of candle installation by inserting equal masses of the oxidant candles (7.6-cm vs 5.1-cm dia). The 5.1-cm dia candles were inserted with direct-push rods while the 7.6-cm candles were housed in screens and lowered into 10 permanent wells. Since installation, the 7.6-cm oxidant candles have been refurbished approximately once per year by gently scraping off surface oxides. In 2012, we reported initial results; in this paper, we provide a 5-yr performance review since installation. Temporal sampling shows oxidant candles placed in wells have steadily reduced migrating TCE concentrations. Moreover, these candles still maintain an inner core of oxidant that has yet to contribute to the dissolution front and should provide several more years of service. Oxidant candles inserted by direct-push have stopped reducing TCE concentrations because a MnO2 scale developed on the outside of the candles. To counteract oxide scaling, we fabricated a second generation of oxidant candles that contain sodium hexametaphosphate. Laboratory experiments (batch and flow-through) show that these second-generation permanganate candles have better release characteristics and are less prone to oxide scaling. This improvement should reduce the need to perform maintenance on candles placed in wells and provide greater longevity for candles inserted by direct-push.

  6. The Heart and Great Vessels.

    Science.gov (United States)

    Onwuka, Ekene; King, Nakesha; Heuer, Eric; Breuer, Christopher

    2017-03-13

    Cardiovascular disease is the leading cause of mortality worldwide. We have made large strides over the past few decades in management, but definitive therapeutic options to address this health-care burden are still limited. Given the ever-increasing need, much effort has been spent creating engineered tissue to replaced diseased tissue. This article gives a general overview of this work as it pertains to the development of great vessels, myocardium, and heart valves. In each area, we focus on currently studied methods, limitations, and areas for future study. Copyright © 2017 Cold Spring Harbor Laboratory Press; all rights reserved.

  7. An optimized procedure greatly improves EST vector contamination removal

    Directory of Open Access Journals (Sweden)

    Wu Huan-Bin

    2007-11-01

    Full Text Available Abstract Background The enormous amount of sequence data available in the public domain database has been a gold mine for researchers exploring various themes in life sciences, and hence the quality of such data is of serious concern to researchers. Removal of vector contamination is one of the most significant operations to obtain accurate sequence data containing only a cDNA insert from the basecalls output by an automatic DNA sequencer. Popular bioinformatics programs to accomplish vector trimming include LUCY, cross_match and SeqClean. Results In a recent study, where the program SeqClean was used to remove vector contamination from our test set of EST data compiled through various library construction systems, however, a significant number of errors remained after preliminary trimming. These errors were later almost completely corrected by simply using a re-linearized form of the cloning vector to compare against the target ESTs. The modified trimming procedure for SeqClean was also compared with the trimming efficiency of the other two popular programs, LUCY2, and cross_match. Using SeqClean with a re-linearized form of the cloning vector significantly surpassed the other two programs in all tested conditions, while the performance of the other two programs was not influenced by the modified procedure. Vector contamination in dbEST was also investigated in this study: 2203 out of the 48212 ESTs sampled from dbEST (2007-04-18 freeze were found to match sequences in UNIVEC. Conclusion Vector contamination remains a serious concern to the data quality in the public sequence database nowadays. Based on the results presented here, we feel that our modified procedure with SeqClean should be recommended to all researchers for the task of vector removal from EST or genomic sequences.

  8. Early morning fledging improves recruitment in great tits Parus major

    NARCIS (Netherlands)

    Radersma, Reinder; Komdeur, Jan; Tinbergen, Joost M.

    2015-01-01

    A potential key event linking the nestling phase to first-year survival is fledging (nest leaving) because this process is characterized by a major change of environments and therefore a sudden shift in selective forces. Here we assessed whether different facets of fledging predicted subsequent surv

  9. Improving Transient Stability in a Grid-Connected Squirrel-Cage Induction Generator Wind Turbine System Using a Fuzzy Logic Controller

    Directory of Open Access Journals (Sweden)

    Minh Quan Duong

    2015-06-01

    Full Text Available A common problem in wind power plants involves fixed-speed wind turbines. In fact, being equipped with a squirrel-cage induction generator (SCIG, they tend to drain a relevant amount of reactive power from the grid, potentially causing voltage drops and possible voltage instability. To improve SCIG power quality and transient stability, this paper investigates a new control strategy for pitch angle control based on proportional-integral (PI controller and a fuzzy logic controller (FLC, considering both normal and fault ride-through (FRT schemes. In the literature, often, the mechanical torque output is assumed constant for a specific wind speed. This might not be accurate, because the mechanical torque-speed typical of a wind turbine depends also on the power coefficient or pitch angle. In this paper, an analytic model of transient stability is proposed using the equivalent circuit of the SCIG and using the concepts of stable and unstable electrical-mechanical equilibrium. The method has been evaluated by comparing the results obtained by the analytic method with the dynamic simulation. The results show that the proposed hybrid controller is effective at smoothing the output power and complying with FRT requirements for SCIG in the power system.

  10. Antimony speciation in soils: improving the detection limits using post-column pre-reduction hydride generation atomic fluorescence spectroscopy (HPLC/pre-reduction/HG-AFS).

    Science.gov (United States)

    Quiroz, Waldo; Olivares, David; Bravo, Manuel; Feldmann, Jorg; Raab, Andrea

    2011-04-15

    HG-AFS is highly sensitive and low cost detection system and its use for antimony chemical speciation coupled to HPLC is gaining popularity. However speciation analysis in soils is strongly hampered because the most efficient extractant reported in the literature (oxalic acid) strongly inhibits the generation of SbH(3) by Sb(V), the major species in this kind of matrix, severely affecting its detection limits. The purpose of this research is to reduce the detection limit of Sb(V), by using a post column on-line reduction system with l-cysteine reagent (HPLC/pre-reduction/HG-AFS). The system was optimized by experimental design, optimum conditions found were 2% (w/v) and 10°C temperature coil. Detection limits of Sb(V) and Sb(III) in oxalic acid (0.25 mol L(-1)) were improved from 0.3 and 0.1 μg L(-1) to 0.07 and 0.07 μg L(-1), respectively. The methodology developed was applied to Chilean soils, where Sb(V) was the predominant species. Copyright © 2011 Elsevier B.V. All rights reserved.

  11. Powerplant Productivity Improvement Study: historic performance of Illinois investor-owned electrical-generating units. Final report, Project 2, Task 1

    Energy Technology Data Exchange (ETDEWEB)

    None

    1979-05-04

    In this task the historical performance of powerplants in Illinois was examined and the opportunities for improved powerplant productivity in Illinois was determined. The four utilities considered were the major investor-owned electric generating utilities in Illinois, i.e., Central Illinois Light Co., (CILCO), Central Illinois Public Service (CIPS), Commonwealth Edison (CECO), and Illinois Power (IP). The major findings are: (1) for evaluation purposes, the equivalent availability was judged to be the most-appropriate measure; (2) in terms of powerplant productivity, IP is among the best in the nation and, in terms of productivity from large coal units, it ranks in the top five nationally; (3) in general, the performance of coal-fired units of CILCO and CECO have been below national averages and in some cases, significantly below; (4) a review of the trends in production of all Illinois units reveals that Illinois units as a group have been generally below national averages for the respective unit classes; (5) as noted in this and other studies, productivities of the nuclear plants in Illinois have been below the national average for all comparable nuclear plants; and (6) this analysis should be updated when national 1977 and 1978 Edison Electric Institute data become publicly available.

  12. An Improved STARFM with Help of an Unmixing-Based Method to Generate High Spatial and Temporal Resolution Remote Sensing Data in Complex Heterogeneous Regions.

    Science.gov (United States)

    Xie, Dengfeng; Zhang, Jinshui; Zhu, Xiufang; Pan, Yaozhong; Liu, Hongli; Yuan, Zhoumiqi; Yun, Ya

    2016-01-01

    Remote sensing technology plays an important role in monitoring rapid changes of the Earth's surface. However, sensors that can simultaneously provide satellite images with both high temporal and spatial resolution haven't been designed yet. This paper proposes an improved spatial and temporal adaptive reflectance fusion model (STARFM) with the help of an Unmixing-based method (USTARFM) to generate the high spatial and temporal data needed for the study of heterogeneous areas. The results showed that the USTARFM had higher accuracy than STARFM methods in two aspects of analysis: individual bands and of heterogeneity analysis. Taking the predicted NIR band as an example, the correlation coefficients (r) for the USTARFM, STARFM and unmixing methods were 0.96, 0.95, 0.90, respectively (p-value < 0.001); Root Mean Square Error (RMSE) values were 0.0245, 0.0300, 0.0401, respectively; and ERGAS values were 0.5416, 0.6507, 0.8737, respectively. The USTARM showed consistently higher performance than STARM when the degree of heterogeneity ranged from 2 to 10, highlighting that the use of this method provides the capacity to solve the data fusion problems faced when using STARFM. Additionally, the USTARFM method could help researchers achieve better performance than STARFM at a smaller window size from its heterogeneous land surface quantitative representation.

  13. Reclamation of heavy metals from contaminated soil using organic acid liquid generated from food waste: removal of Cd, Cu, and Zn, and soil fertility improvement.

    Science.gov (United States)

    Dai, Shijin; Li, Yang; Zhou, Tao; Zhao, Youcai

    2017-06-01

    Food waste fermentation generates complicated organic and acidic liquids with low pH. In this work, it was found that an organic acid liquid with pH 3.28 and volatile low-molecular-weight organic acid (VLMWOA) content of 5.2 g/L could be produced from food wastes after 9-day fermentation. When the liquid-to-solid ratio was 50:1, temperature was 40 °C, and contact time was 0.5-1 day, 92.9, 78.8, and 52.2% of the Cd, Cu, and Zn in the contaminated soil could be washed out using the fermented food waste liquid, respectively. The water-soluble, acid-soluble, and partly reducible heavy metal fractions can be removed after 0.5-day contact time, which was more effective than that using commercially available VLMWOAs (29-72% removal), as the former contained microorganisms and adequate amounts of nutrients (nitrogen, phosphorous, and exchangeable Na, K, and Ca) which favored the washing process of heavy metals. It is thus suggested that the organic acid fractions from food waste has a considerable potential for reclaiming contaminated soil while improving soil fertility.

  14. Thinking Cap Plus Thinking Zap: tDCS of Frontopolar Cortex Improves Creative Analogical Reasoning and Facilitates Conscious Augmentation of State Creativity in Verb Generation.

    Science.gov (United States)

    Green, Adam E; Spiegel, Katherine A; Giangrande, Evan J; Weinberger, Adam B; Gallagher, Natalie M; Turkeltaub, Peter E

    2017-04-01

    Recent neuroimaging evidence indicates neural mechanisms that support transient improvements in creative performance (augmented state creativity) in response to cognitive interventions (creativity cueing). Separately, neural interventions via tDCS show encouraging potential for modulating neuronal function during creative performance. If cognitive and neural interventions are separately effective, can they be combined? Does state creativity augmentation represent "real" creativity, or do interventions simply yield divergence by diminishing meaningfulness/appropriateness? Can augmenting state creativity bolster creative reasoning that supports innovation, particularly analogical reasoning? To address these questions, we combined tDCS with creativity cueing. Testing a regionally specific hypothesis from neuroimaging, high-definition tDCS-targeted frontopolar cortex activity recently shown to predict state creativity augmentation. In a novel analogy finding task, participants under tDCS formulated substantially more creative analogical connections in a large matrix search space (creativity indexed via latent semantic analysis). Critically, increased analogical creativity was not due to diminished accuracy in discerning valid analogies, indicating "real" creativity rather than inappropriate divergence. A simpler relational creativity paradigm (modified verb generation) revealed a tDCS-by-cue interaction; tDCS further enhanced creativity cue-related increases in semantic distance. Findings point to the potential of noninvasive neuromodulation to enhance creative relational cognition, including augmentation of the deliberate effort to formulate connections between distant concepts. © The Author 2016. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

  15. Improved Commutation for Low-Voltage High-Current Vehicle Generators%低压大电流车载发电机改善换向研究

    Institute of Scientific and Technical Information of China (English)

    安跃军; 周利民; 李文瑞; 安辉; 孙丹

    2012-01-01

    为了解决低压大电流车载发电机换向困难和火花等级高的问题,采用非均布和非对称磁极结构、加装非均匀换向极、嵌下具有均压作用的单波绕组和倾斜电刷等措施,以降低换向区磁场和换向电势.应用电磁场有限元方法对车载发电机进行空载和负载内部磁场分析与计算,研究电机内磁力线的分布和气隙磁场波形,结果表明:尽管主磁极极靴和主磁极在空间是不等距分布的,但是主磁极所建立的气隙磁场仍然是对称和均布的,可确保提供适合机电能量转换的媒介空间;通过对比有换向极作用和没有换向极作用时电机内磁场分布和气隙磁场波形,换向极起到了降低换向区磁感应强度的作用,特别是对换向区磁场的细化分析和展示,发现有换向极作用时,换向电势平均降低了42.3%,即有明显改善换向的效果,火花实验也说明换向得到了改善.设计方案可以改善发电机换向条件,降低火花等级,抑制电磁干扰,有利于提高车载电气系统运行稳定性、可靠性和安全性;研究结果为低压大电流车载发电机研制提供技术支持.%To find a way to improve commutation and decrease the level of spark for low-voltage high-current vehicle generators, non-uniformly distributed and asymmetrically constructed magnetic poles, non-uniform commutating magnetic poles, single wave windings with voltage averaged and oblique brush, are adopted. The distribution of the flux line, the wave of the air gap magnetic field, and analysis inner magnetic field under loaded and unloaded conditions are analyzed respectively with finite element method. The results reveal that the magnetic field induced by the main poles is still symmetric and uniform in spite of the asymmetric structure! so it ensures the provision of suitable medium space for mechanical and electrical energy conversion. The commutating poles are able to decrease the magnetic flux

  16. 发电侧如何促进需求侧管理%How to Improve Demand Side Management in Generation Side

    Institute of Scientific and Technical Information of China (English)

    劳德容

    2002-01-01

    Combining with the practice of DSM in China, the paper analyzes the role of engaging demand side management in generation side. Also it deeply studies how to promote demand side management in generation side, which rarelyinvolves in the published literature all over the world. Besides, it discovers the interactions of interdependence and competition between demand side managenent and generation side operation. Lastly it studies the example of demand side management in generation side in Shenzhen.

  17. Great-Britain at CERN

    CERN Multimedia

    2004-01-01

    From 23 to 25 November 2004 Administration Building Bldg 60/61 - ground and 1st floor 09.30 - 17.30 Twenty five companies will present their latest technology at the "Great-Britain at CERN" exhibition. British industry will exhibit products and technologies which are related to the field of particle physics. The main subjects are: electrical engineering, electronics, mechanical engineering, vacuum & low temperatures technologies, particles detectors and telecommunications. The exhibition is organised by BEAMA Exhibitions, The British Electrotechnical and Allied Manufacturer's Association There follows : the list of exhibitors. A detailed programme will be available in due course at : your Departemental secretariat, the reception information desk, Building 33, the exhibition. A detailed list of firms is available under the following FI link: http://fi-dep.web.cern.ch/fi-dep/structure/memberstates/exhibitions_visits.htm 1 Accles & Pollock 2 A S Scientific Products Ltd 3 C...

  18. Great-Britain at CERN

    CERN Multimedia

    C. Laignel

    2004-01-01

    From 23 to 25 November 2004 Administration Building Bldg 60/61 - ground and 1st floor 09.30 - 17.30 Twenty five companies will present their latest technology at the "Great-Britain at CERN" exhibition. British industry will exhibit products and technologies which are related to the field of particle physics. The main subjects are: electrical engineering, electronics, mechanical engineering, vacuum & low temperatures technologies, particles detectors and telecommunications. The exhibition is organised by BEAMA Exhibitions, The British Electrotechnical and Allied Manufacturer's Association There follows : the list of exhibitors. A detailed programme will be available in due course at : your Departemental secretariat, the reception information desk, Building 33, the exhibition. A detailed list of firms is available under the following FI link: http://fi-dep.web.cern.ch/fi-dep/structure/memberstates/exhibitions_visits.htm 1 Accles & Pollock 2 A S Scientific Products Ltd 3 C...

  19. Einstein: The Standard of Greatness

    Energy Technology Data Exchange (ETDEWEB)

    Rigdon, John (Washington University)

    2005-03-16

    Einstein's seven-month performance in 1905 has no equal in the history of physics. Beginning with his revolutionary paper, completed on March 17, and continuing to September 26, Einstein wrote a total of five papers that changed the infrastructure of physics and today, a century later, these papers remain part of the tectonic bedrock of the discipline. How Einstein approached his physics and what he accomplished certainly provided the basis for his world fame. But while the What? and the How? were, and remain, of primary importance, can they explain Einstein's celebrity standing after 1922 and his iconic status today, fifty years after his death? The question remains: Why is Einstein the standard of greatness?

  20. Gypsum karst in Great Britain

    Directory of Open Access Journals (Sweden)

    Cooper A.H.

    1996-01-01

    Full Text Available In Great Britain the most spectacular gypsum karst development is in the Zechstein gypsum (late Permian mainly in north-eastern England. The Midlands of England also has some karst developed in the Triassic gypsum in the vicinity of Nottingham. Along the north-east coast, south of Sunderland, well-developed palaeokarst, with magnificent breccia pipes, was produced by dissolution of Permian gypsum. In north-west England a small gypsum cave system of phreatic origin has been surveyed and recorded. A large actively evolving phreatic gypsum cave system has been postulated beneath the Ripon area on the basis of studies of subsidence and boreholes. The rate of gypsum dissolution here, and the associated collapse lead to difficult civil engineering and construction conditions, which can also be aggravated by water abstraction.

  1. Improvement of Communication Condition from Lunar Rover to Deep Space Tracking Station in Antarctic Great-Wall Station%南极长城站建立深空跟踪站对月球车地-月通信条件的改善

    Institute of Scientific and Technical Information of China (English)

    郝卫峰; 李斐; 叶茂; 张杰

    2012-01-01

    假定在地球南极中国长城科学考察站建立跟踪站,模拟计算月球南极月球车和该跟踪站之间通信的可达性,并和国内跟踪站与南极月球车之间的通信条件进行比较。计算结果表明:①在长城站所建立的跟踪站与月球南极的月球车通信受地形的影响比与我国境内的跟踪站的影响要小;②中国南极长城站和我国境内的跟踪站经度相差180°,综合长城站和我国境内的跟踪站,可以减少由于地球自转而造成的测站背离月球的影响,使观测时段更长。南极长城站建立深空探测跟踪站的通信可达性模拟计算可为我国深空探测网建站的规划及可行性研究提供参考。%If a deep space tracking station is founded in Earth's Antarctic area,communication conditions will be greatly improved attributing to its broader vision.This paper assumes the deep space station is established in Chinese Antarctica Great-Wall station,and simulates the communication accessibility between the lunar rover and the Great-Wall tracking station.Through the comparison with the domestic tracking station's communication condition,the results show that:① The influence of communication condition by topography between the lunar rover in lunar south pole and Great-Wall tracking station is less than that between the lunar rover in lunar south pole and the domestic tracking stations.② The longitude is about 180° from the Chinese Antarctic Great-Wall station to the domestic tracking station.Integrated with all of the tracking stations,including Chinese Antarctic Great-Wall station and domestic tracking stations,the impact of the stations away from the Moon due to the Earth's rotation can be reduced and the tracking time can be lengthened.The simulation and analysis of communication accessibility for choosing Antarctic Great-Wall station as deep space tracking station,can provide a suggestion for the feasibility of construction of the next deep space

  2. Improvement of the decay heat removal characteristics of the generation IV gas-cooled fast reactor; Amelioration des caracteristiques de la dissipation de la chaleur de decroissance pour les reacteurs a neutrons rapides de quatrieme generation refroidi au gaz

    Energy Technology Data Exchange (ETDEWEB)

    Epiney, A.S.

    2010-09-07

    The main drawback of the GFR is the difficulty to evacuate decay heat following a loss-of-coolant accident (LOCA) due to the low thermal inertia of the core, as well as to the low coolant density. The present doctoral research focuses on the improvement of decay heat removal (DHR) for the Generation-IV GFR. The reference GFR system design considered in the thesis is the 2006 CEA concept, with a power of 2400 MWth. The CEA 2006 DHR strategy foresees, in all accidental cases (independent of the system pressure), that the reactor is shut down. For high pressure events, dedicated DHR loops with blowers and heat exchangers are designed to operate when the power conversion system cannot be used to provide acceptable core temperatures under natural convection conditions. For de-pressurized events, the strategy relies on a dedicated small containment (called the guard containment) providing an intermediate back-up pressure. The DHR blowers, designed to work under these pressure conditions, need to be powered either by the power grid or by batteries for at least 24 hours. The specific contributions of the present research - aimed at achieving enhanced passivity of the DHR system for the GFR - are design and analysis related to (1) the injection of heavy gas into the primary circuit after a LOCA, to enable natural convection cooling at an intermediate-pressure level, and (2) an autonomous Brayton loop to evacuate decay heat at low primary pressure in case of a loss of the guard containment pressure. Both these developments reduce the dependence on blower power availability considerably. First, the thermal-hydraulic codes used in the study - TRACE and CATHARE - are validated for gas cooling. The validation includes benchmark comparisons between the codes, serving to identify the sensitivity of the results to the different modeling assumptions. The parameters found to be the most sensitive in this analysis, such as heat transfer and friction models, are then validated via a

  3. Mirror Neurons: Evidence for the Great Simulator and Vrobelism

    Science.gov (United States)

    Rössler, Otto E.

    The deductive biology of brain function is reviewed and brought in contact with recent neurobiological findings. Natural brains predictably possess two components: the force field generator (brain equation) and the Great Simulator (virtual-reality machine). The force field generator contains a preferred time direction, while the Great Simulator can in principle work in both directions of time. The "mirror neurons" discovered empirically by Rizzolatti are interpreted as a predictable manifestation of the Great Simulator. Artificial intelligences that share with us many aspects of the experience of time are possible. The notion of a "temporal fovea" is introduced. It implies a self-similar structure of time over a certain range. This finding confirms a proposal made by Susie Vrobel.

  4. Improved microwave-assisted wet digestion procedures for accurate Se determination in fish and shellfish by flow injection-hydride generation-atomic absorption spectrometry

    Energy Technology Data Exchange (ETDEWEB)

    Lavilla, I. [Departamento de Quimica Analitica y Alimentaria, Area de Quimica Analitica, Universidad de Vigo, Facultad de Ciencias (Quimica), As Lagoas - Marcosende s/n, 36310 Vigo (Spain); Gonzalez-Costas, J.M. [Departamento de Quimica Analitica y Alimentaria, Area de Quimica Analitica, Universidad de Vigo, Facultad de Ciencias (Quimica), As Lagoas - Marcosende s/n, 36310 Vigo (Spain); Bendicho, C. [Departamento de Quimica Analitica y Alimentaria, Area de Quimica Analitica, Universidad de Vigo, Facultad de Ciencias (Quimica), As Lagoas - Marcosende s/n, 36310 Vigo (Spain)]. E-mail: bendicho@uvigo.es

    2007-05-22

    Accurate determination of Se in biological samples, especially fish and shellfish, by hydride generation techniques has generally proven troublesome owing to the presence of organoselenium that cannot readily converted into inorganic selenium under usual oxidising conditions. Further improvements in the oxidation procedures are needed so as to obtain accurate concentration values when this type of samples is analyzed. Microwave-assisted wet digestion (MAWD) procedures of seafood based on HNO{sub 3} or the mixture HNO{sub 3}/H{sub 2}O{sub 2} and further thermal reduction of the Se(VI) formed to Se(IV) were evaluated. These procedures were as follows: (I) without H{sub 2}O{sub 2} and without heating to dryness; (II) without H{sub 2}O{sub 2} and with heating to dryness; (III) with H{sub 2}O{sub 2} and without heating to dryness; (IV) with H{sub 2}O{sub 2} and with heating to dryness. In general, low recoveries of selenium are obtained for several marine species (e.g., crustaceans and cephalopods), which may be ascribed to the presence of Se forms mainly associated with nonpolar proteins and lipids. Post-digestion UV irradiation proved very efficient since not only complete organoselenium decomposition was achieved but also the final step required for prereduction of Se(VI) into Se(IV) (i.e. heating at 90 deg. C for 30 min in 6 M HCl) could be avoided. With the MAWD/UV procedure, the use of strong oxidising agents (persuphate, etc.) or acids (e.g. perchloric acid) which are typically applied prior to Se determination by hydride generation techniques is overcome, and as a result, sample pre-treatment is significantly simplified. The method was successfully validated against CRM DOLT-2 (dogfish liver), CRM DORM-2 (dogfish muscle) and CRM TORT-2 (lobster hepatopancreas). Automated ultrasonic slurry sampling with electrothermal atomic absorption spectrometry was also applied for comparison. Total Se contents in ten seafood samples were established. Se levels ranged from 0

  5. An improved layer-by-layer self-assembly technique to generate biointerfaces for platelet adhesion studies: Dynamic LbL

    Science.gov (United States)

    Lopez, Juan Manuel

    Layer-by-layer self-assembly (LbL) is a technique that generates engineered nano-scale films, coatings, and particles. These nanoscale films have recently been used in multiple biomedical applications. Concurrently, microfabrication methods and advances in microfluidics are being developed and combined to create "Lab-on-a-Chip" technologies. The potential to perform complex biological assays in vitro as a first-line screening technique before moving on to animal models has made the concept of lab on a chip a valuable research tool. Prior studies in the Biofluids Laboratory at Louisiana Tech have used layer-by-layer and in vitro biological assays to study thrombogenesis in a controlled, repeatable, engineered environment. The reliability of these previously established techniques was unsatisfactory for more complex cases such as chemical and shear stress interactions. The work presented in this dissertation was performed to test the principal assumptions behind the established laboratory methodologies, suggest improvements where needed, and test the impact of these improvements on accuracy and repeatability. The assumptions to be tested were: (1) The fluorescence microscopy (FM) images of acridine orange-tagged platelets accurately provide a measure of percent area of surface covered by platelets; (2) fibrinogen coatings can be accurately controlled, interact with platelets, and do not interfere with the ability to quantify platelet adhesion; and (3) the dependence of platelet adhesion on chemical agents, as measured with the modified methods, generally agrees with results obtained from our previous methods and with known responses of platelets that have been documented in the literature. The distribution of fibrinogen on the final LbL surface generated with the standard, static process (s-LbL) was imaged by tagging the fibrinogen with an anti-fibrinogen antibody bound to fluorescein isothiocyanate (FITC). FITC FM images and acridine orange FM images were taken

  6. Development of a System to Generate Near Real Time Tropospheric Delay and Precipitable Water Vapor in situ at Geodetic GPS Stations, to Improve Forecasting of Severe Weather Events

    Science.gov (United States)

    Moore, A. W.; Bock, Y.; Geng, J.; Gutman, S. I.; Laber, J. L.; Morris, T.; Offield, D. G.; Small, I.; Squibb, M. B.

    2012-12-01

    We describe a system under development for generating ultra-low latency tropospheric delay and precipitable water vapor (PWV) estimates in situ at a prototype network of geodetic GPS sites in southern California, and demonstrating their utility in forecasting severe storms commonly associated with flooding and debris flow events along the west coast of North America through infusion of this meteorological data at NOAA National Weather Service (NWS) Forecast Offices and the NOAA Earth System Research Laboratory (ESRL). The first continuous geodetic GPS network was established in southern California in the early 1990s and much of it was converted to real-time (latency tropospheric zenith delays, which can be converted into mm-accuracy PWV using collocated pressure and temperature measurements, the basis for GPS meteorology (Bevis et al. 1992, 1994; Duan et al. 1996) as implemented by NOAA with a nationwide distribution of about 300 GPS-Met stations providing PW estimates at subhourly resolution currently used in operational weather forecasting in the U.S. We improve upon the current paradigm of transmitting large quantities of raw data back to a central facility for processing into higher-order products. By operating semi-autonomously, each station will provide low-latency, high-fidelity and compact data products within the constraints of the narrow communications bandwidth that often occurs in the aftermath of natural disasters. The onsite ambiguity-resolved precise point positioning solutions are enabled by a power-efficient, low-cost, plug-in Geodetic Module for fusion of data from in situ sensors including GPS and a low-cost MEMS meteorological sensor package. The decreased latency (~5 minutes) PW estimates will provide the detailed knowledge of the distribution and magnitude of PW that NWS forecasters require to monitor and predict severe winter storms, landfalling atmospheric rivers, and summer thunderstorms associated with the North American monsoon. On the

  7. Next-generation sequencing in veterinary medicine: how can the massive amount of information arising from high-throughput technologies improve diagnosis, control, and management of infectious diseases?

    Science.gov (United States)

    Van Borm, Steven; Belák, Sándor; Freimanis, Graham; Fusaro, Alice; Granberg, Fredrik; Höper, Dirk; King, Donald P; Monne, Isabella; Orton, Richard; Rosseel, Toon

    2015-01-01

    The development of high-throughput molecular technologies and associated bioinformatics has dramatically changed the capacities of scientists to produce, handle, and analyze large amounts of genomic, transcriptomic, and proteomic data. A clear example of this step-change is represented by the amount of DNA sequence data that can be now produced using next-generation sequencing (NGS) platforms. Similarly, recent improvements in protein and peptide separation efficiencies and highly accurate mass spectrometry have promoted the identification and quantification of proteins in a given sample. These advancements in biotechnology have increasingly been applied to the study of animal infectious diseases and are beginning to revolutionize the way that biological and evolutionary processes can be studied at the molecular level. Studies have demonstrated the value of NGS technologies for molecular characterization, ranging from metagenomic characterization of unknown pathogens or microbial communities to molecular epidemiology and evolution of viral quasispecies. Moreover, high-throughput technologies now allow detailed studies of host-pathogen interactions at the level of their genomes (genomics), transcriptomes (transcriptomics), or proteomes (proteomics). Ultimately, the interaction between pathogen and host biological networks can be questioned by analytically integrating these levels (integrative OMICS and systems biology). The application of high-throughput biotechnology platforms in these fields and their typical low-cost per information content has revolutionized the resolution with which these processes can now be studied. The aim of this chapter is to provide a current and prospective view on the opportunities and challenges associated with the application of massive parallel sequencing technologies to veterinary medicine, with particular focus on applications that have a potential impact on disease control and management.

  8. Macrodystrophia lipomatosa of foot involving great toe.

    Science.gov (United States)

    Gaur, A K; Mhambre, A S; Popalwar, H; Sharma, R

    2014-06-01

    Macrodystrophia lipomatosa is a rare form of congenital disorder in which there is localized gigantism characterized by progressive overgrowth of all mesenchymal elements with a disproportionate increase in the fibroadipose tissues. The adipose tissue infiltration involves subcutaneous tissue, periosteum, nerves and bone marrow. Most of the cases reported have hand or foot involvement. Patient seeks medical help for improving cosmesis or to get the size of the involved part reduced in order to reduce mechanical problems. We report a case of macrodystrophia lipomatosa involving medial side of foot with significant enlargement of great toe causing concern for cosmesis and inconvenience due to mechanical problems. The X-rays showed increased soft tissue with more of adipose tissue and increased size of involved digits with widening of ends. Since the patient's mother did not want any surgical intervention he was educated about foot care and proper footwear design was suggested.

  9. Interfaces - Weak Links, Yet Great Opportunities

    Science.gov (United States)

    Hendricks, Robert C.; Dimofte, Florin; Chupp, Raymond E.; Steinetz, Bruce M.

    2011-01-01

    Inadequate turbomachine interface design can rapidly degrade system performance, yet provide great opportunity for improvements. Engineered coatings of seals and bearing interfaces are major issues in the operational life of power systems. Coatings, films, and combined use of both metals and ceramics play a major role in maintaining component life. Interface coatings, like lubricants, are sacrificial for the benefit of the component. Bearing and sealing surfaces are routinely protected by tribologically paired coatings such as silicon diamond like coatings (SiDLC) in combination with an oil lubricated wave bearing that prolongs bearing operational life. Likewise, of several methods used or researched for detecting interface failures, dopants within coatings show failures in functionally graded ceramic coatings. The Bozzolo-Ferrante-Smith (BFS) materials models and quantum mechanical tools, employed in interface design, are discussed.

  10. Eight Great Community Relations Ideas.

    Science.gov (United States)

    Bete, Tim

    1998-01-01

    Presents eight winners of School Planning & Management's Community Relations Contest that produced ideas that other school districts can use to strengthen community/school coexistence. Papers cover such topics as improving communication between stakeholders, connecting with parents, and keeping the community informed during construction projects.…

  11. Great Principals at Scale: Toolkit

    Science.gov (United States)

    Ikemoto, Gina; Taliaferro, Lori; Fenton, Benjamin; Davis, Jacquelyn

    2014-01-01

    School leaders are critical in the lives of students and to the development of their teachers. Unfortunately, in too many instances, principals are effective in spite of--rather than because of--district conditions. To truly improve student achievement for all students across the country, well-prepared principals need the tools, support, and…

  12. The great carve up continues

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-09-24

    Enel's success in Spain looks suspiciously like the second phase in an Italo-Spanish asset swap. But swaps are notoriously hard to broker, especially when they involve physical assets of varying age and quality in diverse markets. At first sight, Enel would appear to have clinched a rather good deal in 'new Viesgo', while Endesa certainly paid top dollar for Elettrogen. The article discusses these recent events with experts in the field. A table shows Viesgo's generation assets and another gives facts on European plant sales, by fuel type. 2 tabs.

  13. Recognition of two great contemporaries

    Directory of Open Access Journals (Sweden)

    Milin Melita

    2015-01-01

    Full Text Available The common denominator in the careers of two contemporaries and great men, citizens of Austria-Hungary - Leoš Janáček and Sigmund Freud - was that, in spite of their status as outsiders, they managed to achieve well-deserved recognition. Both non-Germans, they had to surmount a number of obstacles in order to attain their professional goals. The Slavophile Janáček dreamed for a long time of success in Prague, which came at last in 1916, two years before a triumph in Vienna. Freud had serious difficulties in his academic career because of the strengthening of racial prejudices and national hatred which were especially marked at the end of the 19th century. After the dissolution of the Empire things changed for the better for the composer, whose works got an excellent reception in Austria and Germany, whereas the psychiatrist had to leave Vienna after the Anschluss. [Projekat Ministarstva nauke Republike Srbije, br. ON 177004: Serbian Musical Identities within Local and Global Frameworks: Traditions, Changes, Challenges

  14. Le Great Limpopo Transfrontier Park

    Directory of Open Access Journals (Sweden)

    Nadia Belaidi

    2008-10-01

    Full Text Available Cet article a pour objet de présenter quelques problématiques d'une recherche sur la construction d’un mécanisme de valorisation sociale de la protection de l’environnement : l’ordre public écologique. Cette étude s’appuie sur une expérience récente et originale en Afrique australe : la création de Parcs pour la Paix dont relève le Great Limpopo Transfrontier Park. Ces parcs sont officiellement consacrés à la protection et à la conservation de la diversité biologique, des ressources naturelles et culturelles qui y sont associées, ainsi qu’à la promotion de la coopération et de la Paix qu’elle soit civile, sociale, économique ou culturelle. La logique de construction de ces parcs repose sur l’idée que l’articulation des zones de conservation facilite la résolution de conflits territoriaux – de toutes sortes – en transformant les préoccupations environnementales en objet de coopération entre des juridictions politiques diverses. C’est précisément le schéma du concept juridique objet de nos travaux : l’ordre public écologique. Aussi peut-on se demander si le GLTP, en particulier, (peut constitue(r une illustration concrète de ce mécanisme et permettre d’atteindre la Paix recherchée, favorisant ainsi les processus de développement ?This article aims to present some problems of researches on the construction of a mechanism of social valorisation of the environmental protection: ecological public order. This study leans on a recent and original experience in southern Africa: the creation of Peace Park like the Great Limpopo Transfrontier Park (GLTP. These parks are officially dedicated to the protection and to the preservation of biological diversity, natural and cultural resources which are associated with it, as well as in the promotion of the cooperation and the peace. The peace looked for in these parks is not only the opposite of the war but it is also social, economic and cultural peace

  15. Great East Japan Earthquake Tsunami

    Science.gov (United States)

    Iijima, Y.; Minoura, K.; Hirano, S.; Yamada, T.

    2011-12-01

    The 11 March 2011, Mw 9.0 Great East Japan Earthquake, already among the most destructive earthquakes in modern history, emanated from a fault rupture that extended an estimated 500 km along the Pacific coast of Honshu. This earthquake is the fourth among five of the strongest temblors since AD 1900 and the largest in Japan since modern instrumental recordings began 130 years ago. The earthquake triggered a huge tsunami, which invaded the seaside areas of the Pacific coast of East Japan, causing devastating damages on the coast. Artificial structures were destroyed and planted forests were thoroughly eroded. Inrush of turbulent flows washed backshore areas and dunes. Coastal materials including beach sand were transported onto inland areas by going-up currents. Just after the occurrence of the tsunami, we started field investigation of measuring thickness and distribution of sediment layers by the tsunami and the inundation depth of water in Sendai plain. Ripple marks showing direction of sediment transport were the important object of observation. We used a soil auger for collecting sediments in the field, and sediment samples were submitted for analyzing grain size and interstitial water chemistry. Satellite images and aerial photographs are very useful for estimating the hydrogeological effects of tsunami inundation. We checked the correspondence of micro-topography, vegetation and sediment covering between before and after the tsunami. The most conspicuous phenomenon is the damage of pine forests planted in the purpose of preventing sand shifting. About ninety-five percent of vegetation coverage was lost during the period of rapid currents changed from first wave. The landward slopes of seawalls were mostly damaged and destroyed. Some aerial photographs leave detailed records of wave destruction just behind seawalls, which shows the occurrence of supercritical flows. The large-scale erosion of backshore behind seawalls is interpreted to have been caused by

  16. An Algorithm on Generating Lattice Based on Layered Concept Lattice

    Directory of Open Access Journals (Sweden)

    Zhang Chang-sheng

    2013-08-01

    Full Text Available Concept lattice is an effective tool for data analysis and rule extraction, a bottleneck factor on impacting the applications of concept lattice is how to generate lattice efficiently. In this paper, an algorithm LCLG on generating lattice in batch processing based on layered concept lattice is developed, this algorithm is based on layered concept lattice, the lattice is generated downward layer by layer through concept nodes and provisional nodes in current layer; the concept nodes are found parent-child relationships upward layer by layer, then the Hasse diagram of inter-layer connection is generated; in the generated process of the lattice nodes in each layer, we do the pruning operations dynamically according to relevant properties, and delete some unnecessary nodes, such that the generating speed is improved greatly; the experimental results demonstrate that the proposed algorithm has good performance.

  17. Great Plains Wind Energy Transmission Development Project

    Energy Technology Data Exchange (ETDEWEB)

    Brad G. Stevens, P.E.; Troy K. Simonsen; Kerryanne M. Leroux

    2012-06-09

    In fiscal year 2005, the Energy & Environmental Research Center (EERC) received funding from the U.S. Department of Energy (DOE) to undertake a broad array of tasks to either directly or indirectly address the barriers that faced much of the Great Plains states and their efforts to produce and transmit wind energy at the time. This program, entitled Great Plains Wind Energy Transmission Development Project, was focused on the central goal of stimulating wind energy development through expansion of new transmission capacity or development of new wind energy capacity through alternative market development. The original task structure was as follows: Task 1 - Regional Renewable Credit Tracking System (later rescoped to Small Wind Turbine Training Center); Task 2 - Multistate Transmission Collaborative; Task 3 - Wind Energy Forecasting System; and Task 4 - Analysis of the Long-Term Role of Hydrogen in the Region. As carried out, Task 1 involved the creation of the Small Wind Turbine Training Center (SWTTC). The SWTTC, located Grand Forks, North Dakota, consists of a single wind turbine, the Endurance S-250, on a 105-foot tilt-up guyed tower. The S-250 is connected to the electrical grid on the 'load side' of the electric meter, and the power produced by the wind turbine is consumed locally on the property. Establishment of the SWTTC will allow EERC personnel to provide educational opportunities to a wide range of participants, including grade school through college-level students and the general public. In addition, the facility will allow the EERC to provide technical training workshops related to the installation, operation, and maintenance of small wind turbines. In addition, under Task 1, the EERC hosted two small wind turbine workshops on May 18, 2010, and March 8, 2011, at the EERC in Grand Forks, North Dakota. Task 2 involved the EERC cosponsoring and aiding in the planning of three transmission workshops in the midwest and western regions. Under Task

  18. TOXAPHENE STUDY OF GREAT LAKES TRIBUTARY SEDIMENTS

    Science.gov (United States)

    The Product is the paper "Pulp and Paper Mills as Sources of Toxaphene to Lake Superior and Northern Lake Michigan" published in the Journal of Great Lakes Research, 25(2):383-394 International Association of Great Lakes 1999.

  19. Preventing Falls: Great Help for Older Americans

    Science.gov (United States)

    ... of this page please turn JavaScript on. Feature: Falls and Older Adults Great Help for Older Americans ... on National Pepper Center website. Read More "Preventing Falls" Articles Preventing Falls / Great Help for Older Adults / ...

  20. Novel chlorambucil-conjugated anionic linear-globular PEG-based second-generation dendrimer: in vitro/in vivo improved anticancer activity

    Directory of Open Access Journals (Sweden)

    Assadi A

    2016-09-01

    Full Text Available Artin Assadi,1 Vahideh Sharifi Najafabadi,1 Seyed Ataollah Sadat Shandiz,2 Azadah Shayeq Boroujeni,1 Sepehr Ashrafi,1 Ali Zaman Vaziri,1 Seyedeh Masoumeh Ghoreishi,1 Mohammad Reza Aghasadeghi,3 Seyed Esmaeil Sadat Ebrahimi,4 Morteza Pirali-Hamedani,4 Mehdi Shafiee Ardestani1 1Department of Radiopharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, 2Young Researchers and Elite Club, East Tehran Branch, Islamic Azad University, 3Department of Hepatitis and AIDS, Pasteur Institute of Iran, 4Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran Abstract: Evaluating the efficacy of anticancer drugs is an evolving and research-oriented issue. The objective of this study was to reduce the insolubility of chlorambucil (CBL in water and improve the anticancer activity of CBL in vitro and in vivo through the conjugation of CBL with anionic linear-globular dendrimer (second generation, G2. In the current study, the anticancer activity among three groups that include CBL, CBL–G2 dendrimer, and control was measured in vitro and in vivo. In vitro studies showed that G2 anionic linear-globular polyethylene-glycol-based dendrimer, which conjugated to the CBL exterior through an ester linkage, was able to significantly improve the treatment efficacy over clinical CBL alone with respect to proliferation assay, 2,3-bis-(2-methoxy-4-nitro-5-sulfophenyl-2H-tetrazolium-5-carboxanilide; half maximal inhibitory concentration (IC50 was calculated to be 141 µg/mL for CBL alone and 27.7 µg/mL for CBL–G2 dendrimer; P<0.05. In addition, CBL–G2 dendrimer conjugate forestalled the growth of MCF-7 cancerous cells in addition to enhancing the number of apoptotic and necrotic cells as demonstrated by an annexin V-fluorescein isothiocyanate assay. CBL–G2 dendrimer conjugate was able to checkmate antiapoptotic Bcl-2 expression and Bcl-2/Bax ratio in a large scale compared with the control group and