Opposite GC skews at the 5' and 3' ends of genes in unicellular fungi
McLean Malcolm A
2011-12-01
Full Text Available Abstract Background GC-skews have previously been linked to transcription in some eukaryotes. They have been associated with transcription start sites, with the coding strand G-biased in mammals and C-biased in fungi and invertebrates. Results We show a consistent and highly significant pattern of GC-skew within genes of almost all unicellular fungi. The pattern of GC-skew is asymmetrical: the coding strand of genes is typically C-biased at the 5' ends but G-biased at the 3' ends, with intermediate skews at the middle of genes. Thus, the initiation, elongation, and termination phases of transcription are associated with different skews. This pattern influences the encoded proteins by generating differential usage of amino acids at the 5' and 3' ends of genes. These biases also affect fourfold-degenerate positions and extend into promoters and 3' UTRs, indicating that skews cannot be accounted by selection for protein function or translation. Conclusions We propose two explanations, the mutational pressure hypothesis, and the adaptive hypothesis. The mutational pressure hypothesis is that different co-factors bind to RNA pol II at different phases of transcription, producing different mutational regimes. The adaptive hypothesis is that cytidine triphosphate deficiency may lead to C-avoidance at the 3' ends of transcripts to control the flow of RNA pol II molecules and reduce their frequency of collisions.
Audenaert, Koenraad M. R., E-mail: koenraad.audenaert@rhul.ac.uk [Department of Mathematics, Royal Holloway University of London, Egham TW20 0EX, United Kingdom and Department of Physics and Astronomy, University of Ghent, S9, Krijgslaan 281, B-9000 Ghent (Belgium)
2014-11-15
In this paper, we study the quantum generalisation of the skew divergence, which is a dissimilarity measure between distributions introduced by Lee in the context of natural language processing. We provide an in-depth study of the quantum skew divergence, including its relation to other state distinguishability measures. Finally, we present a number of important applications: new continuity inequalities for the quantum Jensen-Shannon divergence and the Holevo information, and a new and short proof of Bravyi's Small Incremental Mixing conjecture.
Karl Friston
2010-01-01
Full Text Available We describe a Bayesian filtering scheme for nonlinear state-space models in continuous time. This scheme is called Generalised Filtering and furnishes posterior (conditional densities on hidden states and unknown parameters generating observed data. Crucially, the scheme operates online, assimilating data to optimize the conditional density on time-varying states and time-invariant parameters. In contrast to Kalman and Particle smoothing, Generalised Filtering does not require a backwards pass. In contrast to variational schemes, it does not assume conditional independence between the states and parameters. Generalised Filtering optimises the conditional density with respect to a free-energy bound on the model's log-evidence. This optimisation uses the generalised motion of hidden states and parameters, under the prior assumption that the motion of the parameters is small. We describe the scheme, present comparative evaluations with a fixed-form variational version, and conclude with an illustrative application to a nonlinear state-space model of brain imaging time-series.
Metric adjusted skew information
Hansen, Frank
2008-01-01
establish a connection between the geometrical formulation of quantum statistics as proposed by Chentsov and Morozova and measures of quantum information as introduced by Wigner and Yanase and extended in this article. We show that the set of normalized Morozova-Chentsov functions describing the possible...... quantum statistics is a Bauer simplex and determine its extreme points. We determine a particularly simple skew information, the "¿-skew information," parametrized by a ¿ ¿ (0, 1], and show that the convex cone this family generates coincides with the set of all metric adjusted skew informations.......We extend the concept of Wigner-Yanase-Dyson skew information to something we call "metric adjusted skew information" (of a state with respect to a conserved observable). This "skew information" is intended to be a non-negative quantity bounded by the variance (of an observable in a state...
Skewness preference across countries
Adam Zaremba
2015-07-01
Full Text Available Prospect theory implies that assets with positively skewed returns should be traded at premium to assets with negative skewness. We hypothesize that in the integrated financial markets this concept should also hold for the entire country equity portfolios. This article examines the linkages between the country-level expected returns and past skewness. We evidence a robust negative relationship between skewness and future returns. The phenomenon is most significant within large, liquid, developed, and open stock markets. Additional sorts on skewness can improve performance of both cross-country value and momentum strategies. The study is based on the sorting and cross-sectional tests conducted within a sample of 78 country equity markets for years 1999-2014.
Generalised Geometry and Flux Vacua
Larfors, Magdalena
2015-01-01
This note discusses the connection between generalised geometry and flux compactifications of string theory. Firstly, we explain in a pedestrian manner how the supersymmetry constraints of type II ${\\mathcal{N}}=1$ flux compactifications can be restated as integrability constraints on certain generalised complex structures. This reformulation uses generalised complex geometry, a mathematical framework that geometrizes the B-field. Secondly, we discuss how exceptional generalised geometry may provide a similar geometrization of the RR fields. Thirdly, we examine the connection between generalised geometry and non-geometry, and finally we present recent developments where generalised geometry is used to construct explicit examples of flux compactifications to flat space.
Carbone, Marco; Lindley, Sam; Montesi, Fabrizio
2016-01-01
Wadler introduced Classical Processes (CP), a calculus based on a propositions-as-types correspondence between propositions of classical linear logic and session types. Carbone et al. introduced Multiparty Classical Processes, a calculus that generalises CP to multiparty session types, by replaci...
Quantum Fisher and skew information for Unruh accelerated Dirac qubit
Banerjee, Subhashish; Alok, Ashutosh Kumar [Indian Institute of Technology Jodhpur, Jodhpur (India); Omkar, S. [Indian Institute of Science Education and Research, Thiruvananthapuram (India)
2016-08-15
We develop a Bloch vector representation of the Unruh channel for a Dirac field mode. This is used to provide a unified, analytical treatment of quantum Fisher and skew information for a qubit subjected to the Unruh channel, both in its pure form as well as in the presence of experimentally relevant external noise channels. The time evolution of Fisher and skew information is studied along with the impact of external environment parameters such as temperature and squeezing. The external noises are modelled by both purely dephasing phase damping and the squeezed generalised amplitude damping channels. An interesting interplay between the external reservoir temperature and squeezing on the Fisher and skew information is observed, in particular, for the action of the squeezed generalised amplitude damping channel. It is seen that for some regimes, squeezing can enhance the quantum information against the deteriorating influence of the ambient environment. Similar features are also observed for the analogous study of skew information, highlighting a similar origin of the Fisher and skew information. (orig.)
Generalised Rabin(1) synthesis
Ehlers, Ruediger
2010-01-01
We present a novel method for the synthesis of finite state systems that is a generalisation of the generalised reactivity(1) synthesis approach by Piterman, Pnueli and Sa'ar. In particular, we describe an efficient method to synthesize systems from linear-time temporal logic specifications for which all assumptions and guarantees have a Rabin index of one. We show how to build a parity game with at most five colours that captures all solutions to the synthesis problem from such a specification. This parity game has a structure that is amenable to symbolic implementations. We furthermore show that the results obtained are in some sense tight, i.e., that there does not exist a similar synthesis method for assumptions and specifications of higher Rabin index, unless P=NP.
Generalised twisted partition functions
Petkova, V B
2001-01-01
We consider the set of partition functions that result from the insertion of twist operators compatible with conformal invariance in a given 2D Conformal Field Theory (CFT). A consistency equation, which gives a classification of twists, is written and solved in particular cases. This generalises old results on twisted torus boundary conditions, gives a physical interpretation of Ocneanu's algebraic construction, and might offer a new route to the study of properties of CFT.
Mukhi Sanjay
2002-01-01
Full Text Available A 44 - year -old man presented with generalised progressive lax skin of 14 years duration associated with dysphagia, joint pains and hoarseness of voice. Examination revealed "blood hound" like facies, lox skin with loss of elasticity, dilated tortuous superficial vessels over extremities and back. Systemic involvement noted were oesophageal and pharyngeal diverticuli, inguinal hernia and dermatochalasis. Skin biopsy using Verhoeff Van Gieson′s stain was suggestive of cutis laxa.
Street, Ross
2012-01-01
Spurred by the new examples found by Kornel Szlach\\'anyi of a form of lax monoidal category, the author felt the time ripe to publish a reworking of Eilenberg-Kelly's original paper on closed categories appropriate to the laxer context. The new examples are connected with bialgebroids. With Stephen Lack, we have also used the concept to give an alternative definition of quantum category and quantum groupoid. Szlach\\'anyi has called the lax notion {\\em skew monoidal}. This paper defines {\\em skew closed category}, proves Yoneda lemmas for categories enriched over such, and looks at closed cocompletion.
Mixtures of skewed Kalman filters
Kim, Hyoungmoon
2014-01-01
Normal state-space models are prevalent, but to increase the applicability of the Kalman filter, we propose mixtures of skewed, and extended skewed, Kalman filters. To do so, the closed skew-normal distribution is extended to a scale mixture class of closed skew-normal distributions. Some basic properties are derived and a class of closed skew. t distributions is obtained. Our suggested family of distributions is skewed and has heavy tails too, so it is appropriate for robust analysis. Our proposed special sequential Monte Carlo methods use a random mixture of the closed skew-normal distributions to approximate a target distribution. Hence it is possible to handle skewed and heavy tailed data simultaneously. These methods are illustrated with numerical experiments. © 2013 Elsevier Inc.
Generalised geometry for string corrections
Coimbra, André; Triendl, Hagen; Waldram, Daniel
2014-01-01
We present a general formalism for incorporating the string corrections in generalised geometry, which necessitates the extension of the generalised tangent bundle. Not only are such extensions obstructed, string symmetries and the existence of a well-defined effective action require a precise choice of the (generalised) connection. The action takes a universal form given by a generalised Lichnerowitz--Bismut theorem. As examples of this construction we discuss the corrections linear in $\\alpha'$ in heterotic strings and the absence of such corrections for type II theories.
Brodal, Gerth Stølting; Moruz, Gabriel
2006-01-01
It is well-known that to minimize the number of comparisons a binary search tree should be perfectly balanced. Previous work has shown that a dominating factor over the running time for a search is the number of cache faults performed, and that an appropriate memory layout of a binary search tree...... can reduce the number of cache faults by several hundred percent. Motivated by the fact that during a search branching to the left or right at a node does not necessarily have the same cost, e.g. because of branch prediction schemes, we in this paper study the class of skewed binary search trees....... For all nodes in a skewed binary search tree the ratio between the size of the left subtree and the size of the tree is a fixed constant (a ratio of 1/2 gives perfect balanced trees). In this paper we present an experimental study of various memory layouts of static skewed binary search trees, where each...
Generalising the staircase models
Dorey, P; Dorey, Patrick; Ravanini, Francesco
1993-01-01
Systems of integral equations are proposed which generalise those previously encountered in connection with the so-called staircase models. Under the assumption that these equations describe the finite-size effects of relativistic field theories via the Thermodynamic Bethe Ansatz, analytical and numerical evidence is given for the existence of a variety of new roaming renormalisation group trajectories. For each positive integer $k$ and $s=0,\\dots, k-1$, there is a one-parameter family of trajectories, passing close by the coset conformal field theories $G^{(k)}\\times G^{(nk+s)}/G^{((n+1)k+s)}$ before finally flowing to a massive theory for $s=0$, or to another coset model for $s \
Inequalities for quantum skew information
Audenaert, Koenraad; Cai, Liang; Hansen, Frank
2008-01-01
We study quantum information inequalities and show that the basic inequality between the quantum variance and the metric adjusted skew information generates all the multi-operator matrix inequalities or Robertson type determinant inequalities studied by a number of authors. We introduce an order...... relation on the set of functions representing quantum Fisher information that renders the set into a lattice with an involution. This order structure generates new inequalities for the metric adjusted skew informations. In particular, the Wigner-Yanase skew information is the maximal skew information...... with respect to this order structure in the set of Wigner-Yanase-Dyson skew informations....
Metric-adjusted skew information
Liang, Cai; Hansen, Frank
2010-01-01
We give a truly elementary proof of the convexity of metric-adjusted skew information following an idea of Effros. We extend earlier results of weak forms of superadditivity to general metric-adjusted skew information. Recently, Luo and Zhang introduced the notion of semi-quantum states on a bipa......We give a truly elementary proof of the convexity of metric-adjusted skew information following an idea of Effros. We extend earlier results of weak forms of superadditivity to general metric-adjusted skew information. Recently, Luo and Zhang introduced the notion of semi-quantum states...
Application of Generalised sequential crossover of languages to generalised splicing
Jeganathan, L; Sengupta, Ritabrata
2009-01-01
This paper outlines an application of iterated version of generalised sequential crossover of two languages (which in some sense, an abstraction of the crossover of chromosomes in living organisms) in studying some classes of the newly proposed generalised splicing ($GS$) over two languages. It is proved that, for $X,Y \\in \\{FIN, REG, LIN, CF, CS, RE \\}, \\sg \\in FIN$, the subclass of generalized splicing languages namely $GS(X,Y,\\sg)$, (which is a subclass of the class $GS(X,Y,FIN)$) is always regular.
On Skew Triangular Matrix Rings
Wang Wei-liang; Wang Yao; Ren Yan-li
2016-01-01
Letαbe a nonzero endomorphism of a ring R, n be a positive integer and Tn(R,α) be the skew triangular matrix ring. We show that some properties related to nilpotent elements of R are inherited by Tn(R,α). Meanwhile, we determine the strongly prime radical, generalized prime radical and Behrens radical of the ring R[x;α]/(xn), where R[x;α] is the skew polynomial ring.
Dyads, a generalisation of monads
Fokkinga, Maarten
1994-01-01
The concept of dyad is defined as the least common generalisation of monads and co-monads. So, taking some of the ingredients to be the identity, the concept specialises to the concept of monad, and taking other ingredients to be the identity it specialises to co-monads. Except for one axiom, all
Explanation Based Generalisation = Partial Evaluation
Harmelen, van F.A.H.; Bundy, A.
1988-01-01
We argue that explanation-based generalisation as recently proposed in the machine learning literature is essentially equivalent to partial evaluation, a well known technique in the functional and logic programming literature. We show this equivalence by analysing the definitions and underlying algo
Generalisability of a composite student selection programme
O'Neill, Lotte Dyhrberg; Korsholm, Lars; Wallstedt, Birgitta
2009-01-01
examined the overall test generalisability of composites of non-cognitive admission variables in medical education. We examined the generalisability of a composite process for selection to medicine, consisting of four variables: qualifications (application form information); written motivation (in essay...
Generalised Exponential Families and Associated Entropy Functions
Jan Naudts
2008-07-01
Full Text Available A generalised notion of exponential families is introduced. It is based on the variational principle, borrowed from statistical physics. It is shown that inequivalent generalised entropy functions lead to distinct generalised exponential families. The well-known result that the inequality of CramÃ‚Â´er and Rao becomes an equality in the case of an exponential family can be generalised. However, this requires the introduction of escort probabilities.
Generalised Interval-Valued Fuzzy Soft Set
Shawkat Alkhazaleh; Abdul Razak Salleh
2012-01-01
We introduce the concept of generalised interval-valued fuzzy soft set and its operations and study some of their properties. We give applications of this theory in solving a decision making problem. We also introduce a similarity measure of two generalised interval-valued fuzzy soft sets and discuss its application in a medical diagnosis problem: fuzzy set; soft set; fuzzy soft set; generalised fuzzy soft set; generalised interval-valued fuzzy soft set; interval-valued fuzz...
Dimension and measure of baker-like skew-products of $\\beta$-transformations
Färm, David
2010-01-01
We consider a generalisation of the baker's transformation, consisting of a skew-product of contractions and a $\\beta$-transformation. The Hausdorff dimension and Lebesgue measure of the attractor is calculated for a set of parameters with positive measure. The proofs use a new transverality lemma similar to Solomyak's [Solomyak, 1995]. This transversality, which is applicable to the considered class of maps holds for a larger set of parameters than Solomyak's transversality.
Zhaolin Jiang
2014-01-01
Full Text Available We first give the block style spectral decomposition of arbitrary block skew circulant matrix with skew circulant blocks. Secondly, we obtain the singular value of block skew circulant matrix with skew circulant blocks as well. Finally, based on the block style spectral decomposition, we deal with the optimal backward perturbation analysis for the block skew circulant linear system with skew circulant blocks.
Skew quantum Murnaghan-Nakayama rule
Konvalinka, Matjaz
2011-01-01
In this paper, we extend recent results of Assaf and McNamara on skew Pieri rule and skew Murnaghan-Nakayama rule to a more general identity, which gives an elegant expansion of the product of a skew Schur function with a quantum power sum function in terms of skew Schur functions. We give two proofs, one completely bijective in the spirit of Assaf-McNamara's original proof, and one via Lam-Lauve-Sotille's skew Littlewood-Richardson rule. We end with some conjectures for skew rules for Hall-Littlewood polynomials.
The Generalised Phase Contrast Method
Glückstad, Jesper
. Optimal conditions for visibility, peak irradiance and accuracy are derived and shown to be perfectly in line with empirical results from the literature. New graphic methods for advanced analysis purposes are demonstrated supporting these conclusions as well as providing new tools for innovative filter...... designs and parameter settings. Finally, a number of original applications facilitated by the parallel light-beam encoding of the Generalised Phase Contrast method are briefly outlined. These include among others, wavefront sensing and generation, advanced usercontrolled optical micro......-manipulation, optical phase-only encryption/decryption and fully integrated micro-optical implementations....
Skew Pairs of Idempotents in Transformation Semigroups
T. S. BLYTH; M. H. ALMEIDA SANTOS
2006-01-01
An ordered pair (e, f) of idempotents of a regular semigroup is called a skew pair if ef is not idempotent whereas fe is idempotent. We have shown previously that there are four distinct types of skew pairs of idempotents. Here we investigate the ubiquity of such skew pairs in full transformation semigroups.
Assaf, Sami; Lam, Thomas
2009-01-01
The Pieri rule expresses the product of a Schur function and a single row Schur function in terms of Schur functions. We extend the classical Pieri rule by expressing the product of a skew Schur function and a single row Schur function in terms of skew Schur functions. Like the classical rule, our rule involves simple additions of boxes to the original skew shape.
The skewness of computer science
Franceschet, Massimo
2009-01-01
Computer science is a relatively young discipline combining science, engineering, and mathematics. The main flavors of computer science research involve the theoretical development of conceptual models for the different aspects of computing and the more applicative building of software artifacts and assessment of their properties. In the computer science publication culture, conferences are an important vehicle to quickly move ideas, and journals often publish deeper versions of papers already presented at conferences. These peculiarities of the discipline make computer science an original research field within the sciences, and, therefore, the assessment of classical bibliometric laws is particularly important for this field. In this paper, we study the skewness of the distribution of citations to journals and conference papers published in computer science venues. We find that the skewness in the distribution of mean citedness of different journals combines with the asymmetry in citedness of articles in eac...
Optimal Weak Lensing Skewness Measurements
Zhang, T J; Zhang, P; Dubinski, J; Zhang, Tong-Jie; Pen, Ue-Li; Zhang, Pengjie; Dubinski, John
2003-01-01
Weak lensing measurements are entering a precision era to statistically map the distribution of matter in the universe. The most common measurement has been of the variance of the projected surface density of matter, which corresponds to the induced correlation in alignments of background galaxies. This measurement of the fluctuations is insensitive to the total mass content, like using waves on the ocean to measure its depths. But when the depth is shallow as happens near a beach, waves become skewed. Similarly, a measurement of skewness in the projected matter distribution directly measures the total matter content of the universe. While skewness has already been convincingly detected, its constraint on cosmology is still weak. We address optimal analyses for the CFHT Legacy Survey in the presence of noise. We show that a compensated Gaussian filter with a width of 2.5 arc minutes optimizes the cosmological constraint, yielding $\\Delta \\Omega_m/\\Omega_m\\sim 10%$. This is significantly better than other filt...
The relation between the generalised Eshelby integral and the generalised BCS and DB models
Fan Tian-You; Fan Lei
2011-01-01
The generalised BCS dislocation group model and the generalised DB atomic cohesive force zone model have obtained the same results on nonlinear fracture study of some one-, two-and three-dimensional quasicrystals. This work reveals some inherent connection between the two models, and finds that their common basis is the generalised Eshelby integral based on the generalised Eshelby energy-momentum tensor for quasicrystals. Further applications of the theory in solving nonlinear fracture problems of the materials are also discussed.
Miller, Jodie
2014-01-01
This paper explores how young Indigenous students' (Year 2 and 3) generalise growing patterns. Piagetian clinical interviews were conducted to determine how students articulated growing pattern generalisations. Two case studies are presented displaying how students used gesture to support and articulate their generalisations of growing patterns.…
Generalised maximum entropy and heterogeneous technologies
Oude Lansink, A.G.J.M.
1999-01-01
Generalised maximum entropy methods are used to estimate a dual model of production on panel data of Dutch cash crop farms over the period 1970-1992. The generalised maximum entropy approach allows a coherent system of input demand and output supply equations to be estimated for each farm in the sam
Generalised Computability and Applications to Hybrid Systems
Korovina, Margarita V.; Kudinov, Oleg V.
2001-01-01
We investigate the concept of generalised computability of operators and functionals defined on the set of continuous functions, firstly introduced in [9]. By working in the reals, with equality and without equality, we study properties of generalised computable operators and functionals. Also we...
Supersymmetric backgrounds and generalised special holonomy
Coimbra, André; Strickland-Constable, Charles; Waldram, Daniel
2016-06-01
We define intrinsic torsion in generalised geometry and use it to introduce a new notion of generalised special holonomy. We then consider generic warped supersymmetric flux compactifications of M theory and Type II of the form {{{R}}}D-{1,1}× M. Using the language of {E}d(d)× {{{R}}}+ generalised geometry, we show that, for D≥slant 4, preserving minimal supersymmetry is equivalent to the manifold M having generalised special holonomy and list the relevant holonomy groups. We conjecture that this result extends to backgrounds preserving any number of supersymmetries. As a prime example, we consider { N }=1 in D = 4. The corresponding generalised special holonomy group is {SU}(7), giving the natural M theory extension to the notion of a G 2 manifold, and, for Type II backgrounds, reformulating the pure spinor {SU}(3)× {SU}(3) conditions as an integrable structure.
Supersymmetric Backgrounds and Generalised Special Holonomy
Coimbra, André; Waldram, Daniel
2014-01-01
We define intrinsic torsion in generalised geometry and use it to introduce a new notion of generalised special holonomy. We then consider generic warped supersymmetric flux compactifications of M theory and Type II of the form $\\mathbb{R}^{D-1,1}\\times M$. Using the language of $E_{d(d)}\\times\\mathbb{R}^+$ generalised geometry, we show that, for $D\\geq 4$, preserving minimal supersymmetry is equivalent to the manifold $M$ having generalised special holonomy and list the relevant holonomy groups. We conjecture that this result extends to backgrounds preserving any number of supersymmetries. As a prime example, we consider $\\mathcal{N}=1$ in $D=4$. The corresponding generalised special holonomy group is $SU(7)$, giving the natural M theory extension to the notion of a $G_2$ manifold, and, for Type II backgrounds, reformulating the pure spinor $SU(3)\\times SU(3)$ conditions as an integrable structure.
Wagner’s theory of generalised heaps
Hollings, Christopher D
2017-01-01
The theories of V. V. Wagner (1908-1981) on abstractions of systems of binary relations are presented here within their historical and mathematical contexts. This book contains the first translation from Russian into English of a selection of Wagner’s papers, the ideas of which are connected to present-day mathematical research. Along with a translation of Wagner’s main work in this area, his 1953 paper ‘Theory of generalised heaps and generalised groups,’ the book also includes translations of three short precursor articles that provide additional context for his major work. Researchers and students interested in both algebra (in particular, heaps, semiheaps, generalised heaps, semigroups, and groups) and differential geometry will benefit from the techniques offered by these translations, owing to the natural connections between generalised heaps and generalised groups, and the role played by these concepts in differential geometry. This book gives examples from present-day mathematics where ideas r...
The standard error of the Pearson skew
Bradley Harding
2015-02-01
Full Text Available The Pearson skew is a measure of asymmetry of a distribution, based on the difference between the mean and the median of a distribution. Here we show how to calculate the Pearson skew, estimate its standard error and the confidence interval. The derivation is based on a population following a normal distribution. Simulations explored the validity of this expression when the normality assumption is met in comparison to when the normality assumption is not met. The standard error of the Pearson skew revealed very robust in case of non-normal populations, compared to the Fisher Skew as presented in Harding, Tremblay and Cousineau (2014.
Agrawal, Prateek; Fortes, Elaine C F S; Kilic, Can
2015-01-01
We explore a novel flavor structure in the interactions of dark matter with the Standard Model. We consider theories in which both the dark matter candidate, and the particles that mediate its interactions with the Standard Model fields, carry flavor quantum numbers. The interactions are skewed in flavor space, so that a dark matter particle does not directly couple to the Standard Model matter fields of the same flavor, but only to the other two flavors. This framework respects Minimal Flavor Violation, and is therefore naturally consistent with flavor constraints. We study the phenomenology of a benchmark model in which dark matter couples to right-handed charged leptons. In large regions of parameter space the dark matter can emerge as a thermal relic, while remaining consistent with the constraints from direct and indirect detection. The collider signatures of this scenario include events with multiple leptons and missing energy. These events exhibit a characteristic flavor pattern that may allow this cla...
Generalised Eisenhart lift of the Toda chain
Cariglia, Marco, E-mail: marco@iceb.ufop.br [DEFIS, Universidade Federal de Ouro Preto, Campus Morro do Cruzeiro, 35400-000 Ouro Preto, MG (Brazil); Gibbons, Gary, E-mail: g.w.gibbons@damtp.cam.ac.uk [DAMTP, University of Cambridge, Wilberforce Road, Cambridge CB3 0WA (United Kingdom)
2014-02-15
The Toda chain of nearest neighbour interacting particles on a line can be described both in terms of geodesic motion on a manifold with one extra dimension, the Eisenhart lift, or in terms of geodesic motion in a symmetric space with several extra dimensions. We examine the relationship between these two realisations and discover that the symmetric space is a generalised, multi-particle Eisenhart lift of the original problem that reduces to the standard Eisenhart lift. Such generalised Eisenhart lift acts as an inverse Kaluza-Klein reduction, promoting coupling constants to momenta in higher dimension. In particular, isometries of the generalised lift metric correspond to energy preserving transformations that mix coordinates and coupling constants. A by-product of the analysis is that the lift of the Toda Lax pair can be used to construct higher rank Killing tensors for both the standard and generalised lift metrics.
Generalised Eisenhart lift of the Toda chain
Cariglia, Marco
2013-01-01
The Toda chain of nearest neighbour interacting particles on a line can be described both in terms of geodesic motion on a manifold with one extra dimension, the Eisenhart lift, or in terms of geodesic motion in a symmetric space with several extra dimensions. We examine the relationship between these two realisations and discover that the symmetric space is a generalised, multi-particle Eisenhart lift of the original problem, that reduces to the standard Eisenhart lift. Such generalised Eisenhart lift acts as an inverse Kaluza-Klein reduction, promoting coupling constants to momenta in higher dimension. In particular, isometries of the generalised lift metric correspond to energy preserving transformations that mix coordinates and coupling constants. A by-product of the analysis is that the lift of the Toda Lax pair can be used to construct higher rank Killing tensors for both the standard and generalised lift metrics.
Generalisation of Submarine Features on Nautical Charts
Guilbert, E.; Zhang, X.
2012-07-01
On most large scale and middle scale maps, relief is represented by contours and spot heights. In order to adapt the representation to the scale, the terrain is generalised either by smoothing or filtering the terrain model or by simplifying the contours. However this approach is not applicable to nautical chart construction where terrain features are selected according to their importance for navigation. This paper presents an approach for the consideration of feature attributes in the generalisation of a set of contours with respect to nautical chart constraints. Features are defined by sets of contours and a set of generalisation operators applied to features is presented. The definitions are introduced in a multi-agent system in order to perform automatic generalisation of a contour set. Results are discussed on a case study and directions for future work are presented.
Every flock generalised quadrangle has a hemisystem
Bamberg, John; Royle, Gordon
2009-01-01
We prove that every flock generalised quadrangle contains a hemisystem, and we provide a construction method which unifies our results with the examples of Cossidente and Penttila in the classical case.
Good Codes From Generalised Algebraic Geometry Codes
Jibril, Mubarak; Ahmed, Mohammed Zaki; Tjhai, Cen
2010-01-01
Algebraic geometry codes or Goppa codes are defined with places of degree one. In constructing generalised algebraic geometry codes places of higher degree are used. In this paper we present 41 new codes over GF(16) which improve on the best known codes of the same length and rate. The construction method uses places of small degree with a technique originally published over 10 years ago for the construction of generalised algebraic geometry codes.
Chen Carton W
2007-08-01
Full Text Available Abstract Background Most bacterial chromosomes exhibit asymmetry of base composition with respect to leading vs. lagging strands (GC and AT skews. These skews reflect mainly those in protein coding sequences, which are driven by asymmetric mutation pressures during replication and transcription (notably asymmetric cytosine deamination plus subsequent selection for preferred structures, signals, amino acid or codons. The transcription-associated effects but not the replication-associated effects contribute to the overall skews through the uneven distribution of the coding sequences on the leading and lagging strands. Results Analysis of 185 representative bacterial chromosomes showed diverse and characteristic patterns of skews among different clades. The base composition skews in the coding sequences were used to derive quantitatively the effect of replication-driven mutation plus subsequent selection ('replication-associated pressure', RAP, and the effect of transcription-driven mutation plus subsequent selection at translation level ('transcription-associate pressure', TAP. While different clades exhibit distinct patterns of RAP and TAP, RAP is absent or nearly absent in some bacteria, but TAP is present in all. The selection pressure at the translation level is evident in all bacteria based on the analysis of the skews at the three codon positions. Contribution of asymmetric cytosine deamination was found to be weak to TAP in most phyla, and strong to RAP in all the Proteobacteria but weak in most of the Firmicutes. This possibly reflects the differences in their chromosomal replication machineries. A strong negative correlation between TAP and G+C content and between TAP and chromosomal size were also revealed. Conclusion The study reveals the diverse mutation and selection forces associated with replication and transcription in various groups of bacteria that shape the distinct patterns of base composition skews in the chromosomes during
Automated Generalisation Within NMAs in 2016
Stoter, Jantien; van Altena, Vincent; Post, Marc; Burghardt, Dirk; Duchêne, Cecile
2016-06-01
Producing maps and geo-data at different scales is traditionally one of the main tasks of National (and regional) Mapping Agencies (NMAs). The derivation of low-scale maps (i.e. with less detail) from large-scale maps (with more detail), i.e. generalisation, used to be a manual task of cartographers. With the need for more up-to-date data as well as the development of automated generalisation solutions in both research and industry, NMAs are implementing automated generalisation production lines. To exchange experiences and identify remaining issues, a workshop was organised end 2015 by the Commission on Generalisation and Multirepresentation of the International Cartographic Association and the Commission on Modelling and Processing of the European Spatial Data Research. This paper reports about the workshop outcomes. It shows that, most NMAs have implemented a certain form of automation in their workflows, varying from generalisation of certain features while still maintaining a manual workflow; semiautomated editing and generalisation to a fully automated procedure.
Portfolio optimization with skewness and kurtosis
Lam, Weng Hoe; Jaaman, Saiful Hafizah Hj.; Isa, Zaidi
2013-04-01
Mean and variance of return distributions are two important parameters of the mean-variance model in portfolio optimization. However, the mean-variance model will become inadequate if the returns of assets are not normally distributed. Therefore, higher moments such as skewness and kurtosis cannot be ignored. Risk averse investors prefer portfolios with high skewness and low kurtosis so that the probability of getting negative rates of return will be reduced. The objective of this study is to compare the portfolio compositions as well as performances between the mean-variance model and mean-variance-skewness-kurtosis model by using the polynomial goal programming approach. The results show that the incorporation of skewness and kurtosis will change the optimal portfolio compositions. The mean-variance-skewness-kurtosis model outperforms the mean-variance model because the mean-variance-skewness-kurtosis model takes skewness and kurtosis into consideration. Therefore, the mean-variance-skewness-kurtosis model is more appropriate for the investors of Malaysia in portfolio optimization.
Skewed factor models using selection mechanisms
Kim, Hyoung-Moon
2015-12-21
Traditional factor models explicitly or implicitly assume that the factors follow a multivariate normal distribution; that is, only moments up to order two are involved. However, it may happen in real data problems that the first two moments cannot explain the factors. Based on this motivation, here we devise three new skewed factor models, the skew-normal, the skew-tt, and the generalized skew-normal factor models depending on a selection mechanism on the factors. The ECME algorithms are adopted to estimate related parameters for statistical inference. Monte Carlo simulations validate our new models and we demonstrate the need for skewed factor models using the classic open/closed book exam scores dataset.
Skill Generalisation in Teaching Spelling to Children with Learning Difficulties
Kohnen, Saskia; Nickels, Lyndsey; Coltheart, Max
2010-01-01
A central focus in remedial teaching is the generalisation of responses to contexts in which a student has never been explicitly instructed. Remarkably little is known about how and when generalisation occurs. In this article we examine generalisation effects in the context of spelling. Three areas are discussed: generalisation between spelling…
Gravitational collapse of generalised Vaidya spacetime
Mkenyeleye, Maombi D; Maharaj, Sunil D
2014-01-01
We study the gravitational collapse of a generalised Vaidya spacetime in the context of the Cosmic Censorship hypothesis. We develop a general mathematical framework to study the conditions on the mass function so that future directed non-spacelike geodesics can terminate at the singularity in the past. Thus our result generalises earlier works on gravitational collapse of the combinations of Type-I and Type-II matter fields. Our analysis shows transparently that there exist classes of generalised Vaidya mass functions for which the collapse terminates with a locally naked central singularity. We calculate the strength of the these singularities to show that they are strong curvature singularities and there can be no extension of spacetime through them.
Generalised phase contrast: microscopy, manipulation and more
Palima, Darwin; Glückstad, Jesper
2010-01-01
Generalised phase contrast (GPC) not only leads to more accurate phase imaging beyond thin biological samples, but serves as an enabling framework in developing tools over a wide spectrum of contemporary applications in optics and photonics, including optical trapping and micromanipulation, optic...... phase cryptography, light-efficient image projection and parallel laser beam shaping for optical landscapes. In this review, we discuss the fundamental ideas behind generalised phase contrast and present a survey of its exciting applications.......Generalised phase contrast (GPC) not only leads to more accurate phase imaging beyond thin biological samples, but serves as an enabling framework in developing tools over a wide spectrum of contemporary applications in optics and photonics, including optical trapping and micromanipulation, optical...
Ionads: a generalised notion of topological space
Garner, Richard
2009-01-01
The notion of Grothendieck topos may be considered as a generalisation of that of topological space, one in which the points of the space may have non-trivial automorphisms. However, the analogy is not precise, since in a topological space, it is the points which have conceptual priority over the open sets, whereas in a topos it is the other way around. Hence a topos is more correctly regarded as a generalised locale, than as a generalised space. In this note, we introduce a new notion--that of ionad--which stands in the same relationship to a topological space as a (Grothendieck) topos does to a locale. Some basic aspects of the theory are developed and applications to topology, logic and geometry are discussed.
Recognition of Unipolar and Generalised Split Graphs
Colin McDiarmid
2015-02-01
Full Text Available A graph is unipolar if it can be partitioned into a clique and a disjoint union of cliques, and a graph is a generalised split graph if it or its complement is unipolar. A unipolar partition of a graph can be used to find efficiently the clique number, the stability number, the chromatic number, and to solve other problems that are hard for general graphs. We present an O(n2-time algorithm for recognition of n-vertex generalised split graphs, improving on previous O(n3-time algorithms.
Generalised hyperbolicity in conical space-times
Vickers, J A
2000-01-01
Solutions of the wave equation in a space-time containing a thin cosmic string are examined in the context of non-linear generalised functions. Existence and uniqueness of solutions to the wave equation in the Colombeau algebra G is established for a conical space-time and this solution is shown to be associated to a distributional solution. A concept of generalised hyperbolicity, based on test fields, can be defined for such singular space-times and it is shown that a conical space-time is G-hyperbolic.
Topological String Partition Function on Generalised Conifolds
Gasparim, Elizabeth; Suzuki, Bruno; Torres-Gomez, Alexander
2016-01-01
We show that the partition function on a generalised conifold $C_{m,n}$ with ${m+n \\choose m}$ crepant resolutions can be equivalently computed on the compound du Val singularity $A_{m+n-1}\\times \\mathbb C$ with a unique crepant resolution.
Generalised CP and $\\Delta (96)$ Family Symmetry
Ding, Gui-Jun
2014-01-01
We perform a comprehensive study of the $\\Delta (96)$ family symmetry combined with the generalised CP symmetry $H_{\\rm{CP}}$. We investigate the lepton mixing parameters which can be obtained from the original symmetry $\\Delta (96)\\rtimes H_{\\rm{CP}}$ breaking to different remnant symmetries in the neutrino and charged lepton sectors, namely $G_{\
Generalised Unitarity for Dimensionally Regulated Amplitudes
Bobadilla, W J Torres; Mastrolia, P; Mirabella, E
2015-01-01
We present a novel set of Feynman rules and generalised unitarity cut-conditions for computing one-loop amplitudes via d-dimensional integrand reduction algorithm. Our algorithm is suited for analytic as well as numerical result, because all ingredients turn out to have a four-dimensional representation. We will apply this formalism to NLO QCD corrections.
Hyperscaling Violating Solutions in Generalised EMD Theory
Li, Li
2016-01-01
This short note is devoted to deriving scaling but hyperscaling violating solutions in a generalised Einstein-Maxwell-Dilaton theory with an arbitrary number of scalars and vectors. We obtain analytic solutions in some special case and discuss the physical constraints on the allowed parameter range in order to have a well-defined holographic ground-state solution.
Law of refraction for generalised confocal lenslet arrays
Oxburgh, Stephen
2013-01-01
We derive the law of generalised refraction for generalised confocal lenslet arrays, which are arrays of misaligned telescopes. We have implemented this law of refraction in TIM, a custom open-source ray tracer.
Support Vector Machines and Generalisation in HEP
Bethani, A.; Bevan, A. J.; Hays, J.; Stevenson, T. J.
2016-10-01
We review the concept of support vector machines (SVMs) and discuss examples of their use. One of the benefits of SVM algorithms, compared with neural networks and decision trees is that they can be less susceptible to over fitting than those other algorithms are to over training. This issue is related to the generalisation of a multivariate algorithm (MVA); a problem that has often been overlooked in particle physics. We discuss cross validation and how this can be used to improve the generalisation of a MVA in the context of High Energy Physics analyses. The examples presented use the Toolkit for Multivariate Analysis (TMVA) based on ROOT and describe our improvements to the SVM functionality and new tools introduced for cross validation within this framework.
Support Vector Machines and Generalisation in HEP
Bethani, A; Hays, J; Stevenson, T J
2016-01-01
We review the concept of support vector machines (SVMs) and discuss examples of their use. One of the benefits of SVM algorithms, compared with neural networks and decision trees is that they can be less susceptible to over fitting than those other algorithms are to over training. This issue is related to the generalisation of a multivariate algorithm (MVA); a problem that has often been overlooked in particle physics. We discuss cross validation and how this can be used to improve the generalisation of a MVA in the context of High Energy Physics analyses. The examples presented use the Toolkit for Multivariate Analysis (TMVA) based on ROOT and describe our improvements to the SVM functionality and new tools introduced for cross validation within this framework.
Modification of QUICK scheme by skew points
Mirzaei, M.; Mohammadi, R.; Malekzadeh, M. [K.N. Toosi Univ. of Technology, Aerospace Engineering Dept., Tehran (Iran, Islamic Republic of)]. E-mail: Mirzaei@kntu.ac.ir
2005-07-01
This paper presents a new method for convective flux approximation based on inclusions of skew points. The scheme uses the truncated terms of QUICK scheme and with the aid of an equation extracted from momentum equations, the skew points will appear in the convective flux formula. The results show that the presented scheme has better accuracy than the other schemes. Diffusion fluxes are approximated using power law scheme and for evaluation of the performance of the presented method several test cases were carried out and the results are compared with the results of other numerical works and experimental data. (author)
A Statistical Model of Skewed Associativity
Michaud, Pierre
2002-01-01
This paper presents a statistical model of set-associativity, victim caching and skewed-associativity, with an emphasis on skewed-associativity. We show that set-associativity is not efficient when the working-set size is close to the cache size. We refer to this as the unit working-set problem. We show that victim-caching is not a practical solution to the unit working-se- t problem either, although victim caching emulates full associativity for working-sets much larger than the victim buffe...
Skew chicane based betatron eigenmode exchange module
Douglas, David
2010-12-28
A skewed chicane eigenmode exchange module (SCEEM) that combines in a single beamline segment the separate functionalities of a skew quad eigenmode exchange module and a magnetic chicane. This module allows the exchange of independent betatron eigenmodes, alters electron beam orbit geometry, and provides longitudinal parameter control with dispersion management in a single beamline segment with stable betatron behavior. It thus reduces the spatial requirements for multiple beam dynamic functions, reduces required component counts and thus reduces costs, and allows the use of more compact accelerator configurations than prior art design methods.
Andersen, Per Kragh; Klein, John P.; Rosthøj, Susanne
2003-01-01
Generalised estimating equation; Generalised linear model; Jackknife pseudo-value; Logistic regression; Markov Model; Multi-state model......Generalised estimating equation; Generalised linear model; Jackknife pseudo-value; Logistic regression; Markov Model; Multi-state model...
Sequential experimental design based generalised ANOVA
Chakraborty, Souvik, E-mail: csouvik41@gmail.com; Chowdhury, Rajib, E-mail: rajibfce@iitr.ac.in
2016-07-15
Over the last decade, surrogate modelling technique has gained wide popularity in the field of uncertainty quantification, optimization, model exploration and sensitivity analysis. This approach relies on experimental design to generate training points and regression/interpolation for generating the surrogate. In this work, it is argued that conventional experimental design may render a surrogate model inefficient. In order to address this issue, this paper presents a novel distribution adaptive sequential experimental design (DA-SED). The proposed DA-SED has been coupled with a variant of generalised analysis of variance (G-ANOVA), developed by representing the component function using the generalised polynomial chaos expansion. Moreover, generalised analytical expressions for calculating the first two statistical moments of the response, which are utilized in predicting the probability of failure, have also been developed. The proposed approach has been utilized in predicting probability of failure of three structural mechanics problems. It is observed that the proposed approach yields accurate and computationally efficient estimate of the failure probability.
Sequential experimental design based generalised ANOVA
Chakraborty, Souvik; Chowdhury, Rajib
2016-07-01
Over the last decade, surrogate modelling technique has gained wide popularity in the field of uncertainty quantification, optimization, model exploration and sensitivity analysis. This approach relies on experimental design to generate training points and regression/interpolation for generating the surrogate. In this work, it is argued that conventional experimental design may render a surrogate model inefficient. In order to address this issue, this paper presents a novel distribution adaptive sequential experimental design (DA-SED). The proposed DA-SED has been coupled with a variant of generalised analysis of variance (G-ANOVA), developed by representing the component function using the generalised polynomial chaos expansion. Moreover, generalised analytical expressions for calculating the first two statistical moments of the response, which are utilized in predicting the probability of failure, have also been developed. The proposed approach has been utilized in predicting probability of failure of three structural mechanics problems. It is observed that the proposed approach yields accurate and computationally efficient estimate of the failure probability.
Investors’ Risk Preference Characteristics and Conditional Skewness
Fenghua Wen
2014-01-01
Full Text Available Perspective on behavioral finance, we take a new look at the characteristics of investors’ risk preference, building the D-GARCH-M model, DR-GARCH-M model, and GARCHC-M model to investigate their changes with states of gain and loss and values of return together with other time-varying characteristics of investors’ risk preference. Based on a full description of risk preference characteristic, we develop a GARCHCS-M model to study its effect on the return skewness. The top ten market value stock composite indexes from Global Stock Exchange in 2012 are adopted to make the empirical analysis. The results show that investors are risk aversion when they gain and risk seeking when they lose, which effectively explains the inconsistent risk-return relationship. Moreover, the degree of risk aversion rises with the increasing gain and that of risk seeking improves with the increasing losses. Meanwhile, we find that investors’ inherent risk preference in most countries displays risk seeking, and their current risk preference is influenced by last period’s risk preference and disturbances. At last, investors’ risk preferences affect the conditional skewness; specifically, their risk aversion makes return skewness reduce, while risk seeking makes the skewness increase.
Objective Bayesian Analysis of Skew- t Distributions
BRANCO, MARCIA D'ELIA
2012-02-27
We study the Jeffreys prior and its properties for the shape parameter of univariate skew-t distributions with linear and nonlinear Student\\'s t skewing functions. In both cases, we show that the resulting priors for the shape parameter are symmetric around zero and proper. Moreover, we propose a Student\\'s t approximation of the Jeffreys prior that makes an objective Bayesian analysis easy to perform. We carry out a Monte Carlo simulation study that demonstrates an overall better behaviour of the maximum a posteriori estimator compared with the maximum likelihood estimator. We also compare the frequentist coverage of the credible intervals based on the Jeffreys prior and its approximation and show that they are similar. We further discuss location-scale models under scale mixtures of skew-normal distributions and show some conditions for the existence of the posterior distribution and its moments. Finally, we present three numerical examples to illustrate the implications of our results on inference for skew-t distributions. © 2012 Board of the Foundation of the Scandinavian Journal of Statistics.
Generalised model for anisotropic compact stars
Maurya, S.K. [University of Nizwa, Department of Mathematical and Physical Sciences College of Arts and Science, Nizwa (Oman); Gupta, Y.K. [Raj Kumar Goel Institute of Technology, Department of Mathematics, Ghaziabad, Uttar Pradesh (India); Ray, Saibal [Government College of Engineering and Ceramic Technology, Department of Physics, Kolkata, West Bengal (India); Deb, Debabrata [Indian Institute of Engineering Science and Technology, Shibpur, Department of Physics, Howrah, West Bengal (India)
2016-12-15
In the present investigation an exact generalised model for anisotropic compact stars of embedding class 1 is sought with a general relativistic background. The generic solutions are verified by exploring different physical aspects, viz. energy conditions, mass-radius relation, stability of the models, in connection to their validity. It is observed that the model presented here for compact stars is compatible with all these physical tests and thus physically acceptable as far as the compact star candidates RXJ 1856-37, SAX J 1808.4-3658 (SS1) and SAX J 1808.4-3658 (SS2) are concerned. (orig.)
Generalised sequential crossover of words and languages
Jeganathan, L; Sengupta, Ritabrata
2009-01-01
In this paper, we propose a new operation, Generalised Sequential Crossover (GSCO) of words, which in some sense an abstract model of crossing over of the chromosomes in the living organisms. We extend GSCO over language $L$ iteratively ($GSCO^*(L)$ as well as iterated GSCO over two languages $GSCO^*(L_1,L_2)$). Our study reveals that $GSCO^*(L)$ is subclass of regular languages for any $L$. We compare the different classes of GSCO languages with the prominent sub-regular classes.
Generalised hyperbolicity in spacetimes with singular submanifolds
Sanchez, Yafet Sanchez
2015-01-01
The idea of defining a gravitational singularity as an obstruction to the dynamical evolution of a test field (described by a PDE) rather than the dynamical evolution of a particle (described by a geodesics) is explored. In this paper we obtain general conditions under which the wave equation is well-posed in spacetimes with weak singularities in which the singularity is concentrated in a submanifold. In particular, the results can be applied to spacetimes with shell-crossing singularities, surface layers and generalised cosmic strings.
Generalised matter couplings in massive bigravity
Melville, Scott [Harvard University,Cambridge, Massachusetts 02138 (United States); The Queen’s College,High Street, Oxford, OX1 4AW (United Kingdom); Noller, Johannes [The Queen’s College,High Street, Oxford, OX1 4AW (United Kingdom); Astrophysics, University of Oxford,DWB, Keble Road, Oxford, OX1 3RH (United Kingdom)
2016-01-18
We investigate matter couplings in massive bigravity. We find a new family of such consistent couplings, including and extending known consistent matter couplings, and we investigate their decoupling limits, ADM decompositions, Higuchi bounds and further aspects. We show that differences to previous known consistent couplings only arise beyond the Λ{sub 3} decoupling limit and discuss the uniqueness of consistent matter couplings and how this is related to the so-called symmetric vielbein condition. Since we work in a vielbein formulation, these results easily generalise to multi-gravity.
Skew Pieri Rules for Hall-Littlewood Functions
Konvalinka, Matjaz
2012-01-01
We produce skew Pieri Rules for Hall--Littlewood functions in the spirit of Assaf and McNamara. The first two were conjectured by the first author. The key ingredients in the proofs are a q-binomial identity for skew partitions and a Hopf algebraic identity that expands products of skew elements in terms of the coproduct and the antipode.
Categorification of skew-symmetrizable cluster algebras
Demonet, Laurent
2009-01-01
We propose a new framework for categorifying skew-symmetrizable cluster algebras. Starting from an exact stably 2-Calabi-Yau category C endowed with the action of a finite group G, we construct a G-equivariant mutation on the set of maximal rigid G-invariant objects of C. Using an appropriate cluster character, we can then attach to these data an explicit skew-symmetrizable cluster algebra. As an application we prove the linear independence of the cluster monomials in this setting. Finally, we illustrate our construction with examples associated with partial flag varieties and unipotent subgroups of Kac-Moody groups, generalizing to the non simply-laced case several results of Gei\\ss-Leclerc-Schr\\"oer.
Topological Conjugacy Between Skew Tent Maps
Shi, Yong-Guo; Wang, Zhihua
This paper investigates the conjugacy of any two skew tent maps. An explicit formula is given for the conjugacy. It is proved that the conjugacy is singular, Hölder continuous and not differentiable as well as its inverse. We calculate the arc-length of the conjugacy curve and the area under the conjugacy curve. We construct a sequence of functions to approximate the conjugacy, and give an estimation for the error of the approximation.
Dimensions of attractors in pinched skew products
Gröger, M.; Jäger, T.
2011-01-01
We study dimensions of strange non-chaotic attractors and their associated physical measures in so-called pinched skew products, introduced by Grebogi and his coworkers in 1984. Our main results are that the Hausdorff dimension, the pointwise dimension and the information dimension are all equal to one, although the box-counting dimension is known to be two. The assertion concerning the pointwise dimension is deduced from the stronger result that the physical measure is rectifiable. Our findi...
Linear algebra for skew-polynomial matrices
Abramov, Sergei; Bronstein, Manuel
2002-01-01
We describe an algorithm for transforming skew-polynomial matrices over an Ore domain in row-reduced form, and show that this algorithm can be used to perform the standard calculations of linear algebra on such matrices (ranks, kernels, linear dependences, inhomogeneous solving). The main application of our algorithm is to desingularize recurrences and to compute the rational solutions of a large class of linear functional systems. It also turns out to be efficient when applied to ordinary co...
Maximal Subgroups of Skew Linear Groups
M. Mahdavi-Hezavehi
2002-01-01
Let D be an infinite division algebra of finite dimension over its centre Z(D) = F, and n a positive integer. The structure of maximal subgroups of skew linear groups are investigated. In particular, assume N is a normal subgroup of GLn(D) and M is a maximal subgroup of N containing Z(N). It is shown that if M/Z(N) is finite, then N is central.
Generalised structures for N=1 AdS backgrounds
Coimbra, André [Institut für Theoretische Physik & Center for Quantum Engineering and Spacetime Research,Leibniz Universität Hannover,Appelstraße 2, 30167 Hannover (Germany); Strickland-Constable, Charles [Institut de physique théorique, Université Paris Saclay, CEA, CNRS, Orme des Merisiers, F-91191 Gif-sur-Yvette (France)
2016-11-16
We expand upon a claim made in a recent paper [http://arxiv.org/abs/1411.5721] that generic minimally supersymmetric AdS backgrounds of warped flux compactifications of Type II and M theory can be understood as satisfying a straightforward weak integrability condition in the language of E{sub d(d)}×ℝ{sup +} generalised geometry. Namely, they are spaces admitting a generalised G-structure set by the Killing spinor and with constant singlet generalised intrinsic torsion.
3D skewing and de-skewing scheme for conflict-free access to rays in volume rendering
Cohen-or, D.; Kaufman, A. [Tel-Aviv Univ., Ramat Aviv (Israel)
1995-05-01
We extend a 2D linear skewed memory organization to 3D and introduce the associated de-skewing scheme designed to provide conflict-free access to projection rays of voxels for use in a volume rendering architecture. This is an application of a 3D linear skewing scheme which supports real-time axonometric projection from 26 primary orientations. 17 refs.
Asymptotic Behaviour of Total Generalised Variation
Papafitsoros, Konstantinos
2015-01-01
© Springer International Publishing Switzerland 2015. The recently introduced second order total generalised variation functional TGV2 β,α has been a successful regulariser for image processing purposes. Its definition involves two positive parameters α and β whose values determine the amount and the quality of the regularisation. In this paper we report on the behaviour of TGV2 β,α in the cases where the parameters α, β as well as their ratio β/α becomes very large or very small. Among others, we prove that for sufficiently symmetric two dimensional data and large ratio β/α, TGV2 β,α regularisation coincides with total variation (TV) regularization
Quantum mechanics of a generalised rigid body
Gripaios, Ben
2015-01-01
We consider the quantum version of Arnold's generalisation of a rigid body in classical mechanics. Thus, we quantise the motion on an arbitrary Lie group manifold of a particle whose classical trajectories correspond to the geodesics of any one-sided-invariant metric. We show how the derivation of the spectrum of energy eigenstates can be simplified by making use of automorphisms of the Lie algebra and (for groups of Type I) by methods of harmonic analysis. As examples, we consider all connected and simply-connected Lie groups up to dimension 3. This includes the universal cover of the archetypical rigid body, along with a number of new exactly-solvable models. We also discuss a possible application to the topical problem of quantising a perfect fluid.
Clinical profile of severe generalised tetanus patients
Shastri M
2017-04-01
Full Text Available Background Tetanus, a rare disease in today’s world, when occurs, takes a devastating course. However, with proper treatment and ventilatory support, patients with tetanus can survive and lead a healthy event-free life. Aims To describe the clinical features, course, complications, treatment and outcomes in patients admitted to the medical intensive care unit (MICU with severe generalised tetanus requiring mechanical ventilation. Methods A prospective study was conducted between September 2014 to February 2016, on 40 patients who had severe generalised tetanus. Adult patients (above 12 years age who required mechanical ventilatory support were included. A detailed history, laboratory parameters, medications, supportive medical care, duration of mechanical ventilation and outcome were studied. Outcomes were defined as complete recovery or death. Results This study showed male to female ratio of 3:1, with 67.5 per cent patients under the age of 40 years. Most of the patients (95 per cent were from rural population and all patients were unimmunized. Mortality was 82.6 per cent, when period of onset was less than two days. Autonomic dysfunction was the attributed cause of death in first seven days of hospital stay, while from second week onwards death was due to secondary complications (sepsis, ventilator associated pneumonia, etc.. Overall mortality rate was 52.5 per cent. Conclusion Shorter the period of onset, more severe the disease, and high the mortality. Early mortality was attributed to autonomic dysfunction, while late mortality is attributed to secondary complications. These results matched with the existing literature and historical studies.
Dimensions of Attractors in Pinched Skew Products
Gröger, M.; Jäger, T.
2013-05-01
We study dimensions of strange non-chaotic attractors and their associated physical measures in so-called pinched skew products, introduced by Grebogi and his coworkers in 1984. Our main results are that the Hausdorff dimension, the pointwise dimension and the information dimension are all equal to one, although the box-counting dimension is known to be two. The assertion concerning the pointwise dimension is deduced from the stronger result that the physical measure is rectifiable. Our findings confirm a conjecture by Ding, Grebogi and Ott from 1989.
Dimensions of attractors in pinched skew products
Gröger, M
2011-01-01
We study dimensions of strange non-chaotic attractors and their associated physical measures in so-called pinched skew products, introduced by Grebogi and his coworkers in 1984. Our main results are that the Hausdorff dimension, the pointwise dimension and the information dimension are all equal to one, although the box-counting dimension is known to be two. The assertion concerning the pointwise dimension is deduced from the stronger result that the physical measure is rectifiable. Our findings confirm a conjecture by Ding, Grebogi and Ott from 1989.
Coherence for Skew-Monoidal Categories
Tarmo Uustalu
2014-06-01
Full Text Available I motivate a variation (due to K. Szlachányi of monoidal categories called skew-monoidal categories where the unital and associativity laws are not required to be isomorphisms, only natural transformations. Coherence has to be formulated differently than in the well-known monoidal case. In my (to my knowledge new version, it becomes a statement of uniqueness of normalizing rewrites. I present a proof of this coherence theorem and also formalize it fully in the dependently typed programming language Agda.
Skew-symmetric distributions and Fisher information : The double sin of the skew-normal
Hallin, M.; Ley, C.
2014-01-01
Hallin and Ley [Bernoulli 18 (2012) 747–763] investigate and fully characterize the Fisher singularity phenomenon in univariate and multivariate families of skew-symmetric distributions. This paper proposes a refined analysis of the (univariate) problem, showing that singularity can be more or less
SKEWNESS OF RETURN DISTRIBUTION AND COEFFICIENT OF RISK PREMIUM
Fenghua WEN; Xiaoguang YANG
2009-01-01
The skewness of the return distribution is one of the important features of the security price. In this paper, the authors try to explore the relationship between the skewness and the coefficient of risk premium. The coefficient of the risk premium is estimated by a GARCH-M model, and the robust measurement of skewness is calculated by Groeneveld-Meeden method. The empirical evidences for the composite indexes from 33 securities markets in the world indicate that the risk compensation requirement in the market where the return distribution is positively skewed is virtually zero, and the risk compensation requirement is positive in a significant level in the market where the return distribution is negative skewed. Moreover, the skewness is negatively correlated with the coefficient of the risk premium.
Bayesian modeling growth curves for quail assuming skewness in errors
Robson Marcelo Rossi
2014-06-01
Full Text Available Bayesian modeling growth curves for quail assuming skewness in errors - To assume normal distributions in the data analysis is common in different areas of the knowledge. However we can make use of the other distributions that are capable to model the skewness parameter in the situations that is needed to model data with tails heavier than the normal. This article intend to present alternatives to the assumption of the normality in the errors, adding asymmetric distributions. A Bayesian approach is proposed to fit nonlinear models when the errors are not normal, thus, the distributions t, skew-normal and skew-t are adopted. The methodology is intended to apply to different growth curves to the quail body weights. It was found that the Gompertz model assuming skew-normal errors and skew-t errors, respectively for male and female, were the best fitted to the data.
Skewed norms under peer pressure: Formation and collapse
Michaeli, Moti; Spiro, Daniel
2014-01-01
This paper shows that peer pressure may lead to dynamic convergence to a norm that is skewed with respect to preferences in society, yet is endogenously upheld by the population. Moreover, a skewed norm will often be more sustainable than a representative norm. This may explain the skewness of various social and religious norms. By furthermore interpreting a norm as a political regime, we show that biased regimes can be sustained even without the existence of a powerful group with coherent in...
Coefficient of variation calculated from the range for skewed distributions.
Rhiel, G Steven
2006-02-01
In this research a coefficient of variation (CVS(high.low)) is developed that is calculated from the highest and lowest values in a set of data for samples from skewed distributions. A correction factor is determined such that CVS(high-low) is a dose estimate of the population coefficient of variation when sampling from three skewed chi-squared distributions and three skewed empirical distributions. The empirical distributions are from "real-world" data sets in psychology and education.
Threshold corrections, generalised prepotentials and Eichler integrals
Carlo Angelantonj
2015-08-01
Full Text Available We continue our study of one-loop integrals associated to BPS-saturated amplitudes in N=2 heterotic vacua. We compute their large-volume behaviour, and express them as Fourier series in the complexified volume, with Fourier coefficients given in terms of Niebur–Poincaré series in the complex structure modulus. The closure of Niebur–Poincaré series under modular derivatives implies that such integrals derive from holomorphic prepotentials fn, generalising the familiar prepotential of N=2 supergravity. These holomorphic prepotentials transform anomalously under T-duality, in a way characteristic of Eichler integrals. We use this observation to compute their quantum monodromies under the duality group. We extend the analysis to modular integrals with respect to Hecke congruence subgroups, which naturally arise in compactifications on non-factorisable tori and freely-acting orbifolds. In this case, we derive new explicit results including closed-form expressions for integrals involving the Γ0(N Hauptmodul, a full characterisation of holomorphic prepotentials including their quantum monodromies, as well as concrete formulæ for holomorphic Yukawa couplings.
Do horses generalise between objects during habituation?
Christensen, Janne Winther; Zharkikh, Tatjana; Ladevig, Jan
2008-01-01
Habituation to frightening stimuli plays an important role in horse training. To investigate the extent to which horses generalise between different visual objects, 2-year-old stallions were habituated to feeding from a container placed inside a test arena and assigned as TEST (n = 12) or REFERENCE...... horses (n = 12). In Experiment 1, TEST horses were habituated to six objects (ball, barrel, board, box, cone, cylinder) presented in sequence in a balanced order. The objects were of similar size but different colour. Each object was placed 0.5 m in front of the feed container, forcing the horses to pass...... the object to get to the food. TEST horses received as many 2 min exposures to each object as required to meet a habituation criterion. We recorded behavioural reactions to the object, latency to feed, total eating time, and heart rate (HR) during all exposures. There was no significant decrease in initial...
Skew Detection for Binary Document Images Using Mathematical Morphyology
无
2002-01-01
The input document images with skew can be a serious problem in the optical character recognition system. A method is proposed for skew detection in binary document images using mathematic morphology. The basic process of our approach consists of three steps: Firstly, a dilation operation is applied to the binary image; Secondly, the dilated image is thinned; Finally, the skew angle is detected using the Hough transform. The proposed approach with high precision can detect skew with large angle (-90°-90°). The experimental result shows this method is applicable and efficient.
Robust skew estimation using straight lines in document images
Koo, Hyung Il; Cho, Nam Ik
2016-05-01
A skew-estimation method using straight lines in document images is presented. Unlike conventional approaches exploiting the properties of text, we formulate the skew-estimation problem as an estimation task using straight lines in images and focus on robust and accurate line detection. To be precise, we adopt a block-based edge detector followed by a progressive line detector to take clues from a variety of sources such as text lines, boundaries of figures/tables, vertical/horizontal separators, and boundaries of textblocks. Extensive experiments on the datasets of skewed images and competition results reveal that the proposed method works robustly and yields accurate skew-estimation results.
ON SKEW-NORMAL MODEL FOR ECONOMICALLY ACTIVE POPULATION
OLOSUNDE AKINLOLU A
2011-04-01
Full Text Available The literature related to skew-symmetric distribution have grown rapidly in recent years but at the moment no publication on its applications concerning the description of economically active data with this type of probability models. In this paper, we provided an extension to this skew-normal distribution, which is also part of the family of skewed class of normal but with additional shape parameters δ. Some properties of this distribution are presented and finally, we considered fitting it to economically active population data. The model exhibited a better behaviour when compared to normal and skew normal distributions.
Gait analysis of adults with generalised joint hypermobility
Simonsen, Erik B; Tegner, Heidi; Alkjær, Tine;
2012-01-01
BACKGROUND: The majority of adults with Generalised Joint Hypermobility experience symptoms such as pain and joint instability, which is likely to influence their gait pattern. Accordingly, the purpose of the present project was to perform a biomechanical gait analysis on a group of patients...... with Generalised Joint Hypermobility and compare them to a group of healthy subjects. METHODS: Seventeen adults clinically classified with Generalised Joint Hypermobility (6 males and 11 females) and seventeen healthy subjects (9 males and 8 females) were included in the project. The subjects walked across three...
Skew t distribution and its moments
Saralees NADARAJAH; Arjun K.GUPTA
2006-01-01
A random variable X is said to have the skew- t distribution if its pdf is f (x) = 2g (x) G (λx), where g (·) and G(·), respectively, denote the pdf and the cdf of the Student's t distribution with degrees of freedom ν. The moments of this distribution appear not to have been studied in detail. In this paper, we derive general expressions for the nth moment of X by considering the cases ν odd and ν even separately. These expressions turn out to involve sums of the Gauss hypergeometric function. We also provide closed form expressions for the moments of X for the particular cases ν = 2, …, 10.
Acute generalised exanthematous pustulosis secondary to cotrimoxazole or tenofovir
J Black
2012-11-01
Full Text Available Cutaneous adverse drug reactions are a common complication of antiretroviral therapy and of drugs used to treat opportunistic infections. We present a rare case of acute generalised exanthematous pustulosis secondary to cotrimoxazole or tenofovir.
Exceptional generalised geometry for massive IIA and consistent reductions
Cassani, Davide; Petrini, Michela; Strickland-Constable, Charles; Waldram, Daniel
2016-01-01
We develop an exceptional generalised geometry formalism for massive type IIA supergravity. In particular, we construct a deformation of the generalised Lie derivative, which generates the type IIA gauge transformations as modified by the Romans mass. We apply this new framework to consistent Kaluza-Klein reductions preserving maximal supersymmetry. We find a generalised parallelisation of the exceptional tangent bundle on S^6, and from this reproduce the consistent truncation ansatz and embedding tensor leading to dyonically gauged ISO(7) supergravity in four dimensions. We also discuss closely related hyperboloid reductions, yielding a dyonic ISO(p,7-p) gauging. Finally, while for vanishing Romans mass we find a generalised parallelisation on S^d, d=4,3,2, leading to a maximally supersymmetric reduction with gauge group SO(d+1) (or larger), we provide evidence that an analogous reduction does not exist in the massive theory.
Supersymmetric backgrounds, the Killing superalgebra, and generalised special holonomy
Coimbra, André [Institut des Hautes Études Scientifiques, Le Bois-Marie,35 route de Chartres, F-91440 Bures-sur-Yvette (France); Strickland-Constable, Charles [Institut des Hautes Études Scientifiques, Le Bois-Marie,35 route de Chartres, F-91440 Bures-sur-Yvette (France); Institut de physique théorique, Université Paris Saclay, CEA, CNRS,Orme des Merisiers, F-91191 Gif-sur-Yvette (France)
2016-11-10
We prove that, for M theory or type II, generic Minkowski flux backgrounds preserving N supersymmetries in dimensions D≥4 correspond precisely to integrable generalised G{sub N} structures, where G{sub N} is the generalised structure group defined by the Killing spinors. In other words, they are the analogues of special holonomy manifolds in E{sub d(d)}×ℝ{sup +} generalised geometry. In establishing this result, we introduce the Kosmann-Dorfman bracket, a generalisation of Kosmann’s Lie derivative of spinors. This allows us to write down the internal sector of the Killing superalgebra, which takes a rather simple form and whose closure is the key step in proving the main result. In addition, we find that the eleven-dimensional Killing superalgebra of these backgrounds is necessarily the supertranslational part of the N-extended super-Poincaré algebra.
Exceptional generalised geometry for massive IIA and consistent reductions
Cassani, Davide; de Felice, Oscar; Petrini, Michela; Strickland-Constable, Charles; Waldram, Daniel
2016-08-01
We develop an exceptional generalised geometry formalism for massive type IIA supergravity. In particular, we construct a deformation of the generalised Lie derivative, which generates the type IIA gauge transformations as modified by the Romans mass. We apply this new framework to consistent Kaluza-Klein reductions preserving maximal supersymmetry. We find a generalised parallelisation of the exceptional tangent bundle on S 6, and from this reproduce the consistent truncation ansatz and embedding tensor leading to dyonically gauged ISO(7) supergravity in four dimensions. We also discuss closely related hyperboloid reductions, yielding a dyonic ISO( p, 7 - p) gauging. Finally, while for vanishing Romans mass we find a generalised parallelisation on S d , d = 4 , 3 , 2, leading to a maximally supersymmetric reduction with gauge group SO( d + 1) (or larger), we provide evidence that an analogous reduction does not exist in the massive theory.
Noncommutative differential geometry, and the matrix representations of generalised algebras
Gratus, J.
1998-05-01
The underly ing algebra I or a noncummutative geometry is taken to be a matrix algebra, and the set of derivatives the ad joint of a subset of traceless matrices. This is sufficient to calculate the dual 1-forms, and show that the space of 1-firms is at free module over the algebra of matrices. The concept of a generalised algebra is delined and it is shown that this is required in order for the space of 2-forms to exist, The exterior derivative is generalised for higher-order forms and these are also shown to he free modules over the matrix algebra. Examples of mappings that preserve the differential Structure are peen, Also giken are four examples of matrix generalised algebras, and the corresponding noncommutntive geometries, including the cases where the generalised algebra corresponds to a representation of a Lie algebra or a q-deformed algebra.
Supersymmetric Backgrounds, the Killing Superalgebra, and Generalised Special Holonomy
Coimbra, André
2016-01-01
We prove that, for M theory or type II, generic Minkowski flux backgrounds preserving $\\mathcal{N}$ supersymmetries in dimensions $D\\geq4$ correspond precisely to integrable generalised $G_{\\mathcal{N}}$ structures, where $G_{\\mathcal{N}}$ is the generalised structure group defined by the Killing spinors. In other words, they are the analogues of special holonomy manifolds in $E_{d(d)} \\times\\mathbb{R}^+$ generalised geometry. In establishing this result, we introduce the Kosmann-Dorfman bracket, a generalisation of Kosmann's Lie derivative of spinors. This allows us to write down the internal sector of the Killing superalgebra, which takes a rather simple form and whose closure is the key step in proving the main result. In addition, we find that the eleven-dimensional Killing superalgebra of these backgrounds is necessarily the supertranslational part of the $\\mathcal{N}$-extended super-Poincar\\'e algebra.
Supersymmetric backgrounds, the Killing superalgebra, and generalised special holonomy
Coimbra, André; Strickland-Constable, Charles
2016-11-01
We prove that, for M theory or type II, generic Minkowski flux backgrounds preserving N supersymmetries in dimensions D ≥ 4 correspond precisely to integrable generalised {G}_{N} structures, where {G}_{N} is the generalised structure group defined by the Killing spinors. In other words, they are the analogues of special holonomy manifolds in {E}_{d(d)}× {R}+ generalised geometry. In establishing this result, we introduce the Kosmann-Dorfman bracket, a generalisation of Kosmann's Lie derivative of spinors. This allows us to write down the internal sector of the Killing superalgebra, which takes a rather simple form and whose closure is the key step in proving the main result. In addition, we find that the eleven-dimensional Killing superalgebra of these backgrounds is necessarily the supertranslational part of the N -extended super-Poincaré algebra.
Rational first integrals of geodesic equations and generalised hidden symmetries
Aoki, Arata; Tomoda, Kentaro
2016-01-01
We discuss novel generalisations of Killing tensors, which are introduced by considering rational first integrals of geodesic equations. We introduce the notion of inconstructible generalised Killing tensors, which cannot be constructed from ordinary Killing tensors. Moreover, we introduce inconstructible rational first integrals, which are constructed from inconstructible generalised Killing tensors, and provide a method for checking the inconstructibility of a rational first integral. Using the method, we show that the rational first integral of the Collinson-O'Donnell solution is not inconstructible. We also provide several examples of metrics admitting an inconstructible rational first integral in two and four dimensions, by using the Maciejewski-Przybylska system. Furthermore, we attempt to generalise other hidden symmetries such as Killing-Yano tensors.
Form Invariant Sommerfeld Electrical Conductivity in Generalised d Dimensions
Muktish Acharyya
2011-01-01
The Sommerfeld electrical conductivity is calculated in d dimensions following Boltzmann kinetic approach. At T =0, the mathematical form of the electrical conductivity is found to remain invariant in any generalised spatial （d） dimensions.
Generalisation of fear and avoidance along a semantic continuum.
Boyle, Sean; Roche, Bryan; Dymond, Simon; Hermans, Dirk
2016-01-01
Directly conditioned fear and avoidance readily generalises to dissimilar but conceptually related stimuli. Here, for the first time, we examined the conceptual/semantic generalisation of both fear and avoidance using real words (synonyms). Participants were first exposed to a differential fear conditioning procedure in which one word (e.g., "broth"; CS+) was followed with brief electric shock [unconditioned stimulus (US)] and another was not (e.g., "assist"; CS-). Next, an instrumental conditioning phase taught avoidance in the presence the CS+ but not the CS-. During generalisation testing, synonyms of the CS+ (e.g., "soup"; GCS+) and CS- (e.g., "help"; GCS-) were presented in the absence of shock. Conditioned fear and avoidance, measured via skin conductance responses, behavioural avoidance and US expectancy ratings, generalised to the semantically related, but not to the semantically unrelated, synonyms. Findings have implications for how natural language categories and concepts mediate the expansion of fear and avoidance repertoires in clinical contexts.
Generalised Impedance Converters with only Transconductance Elements and Grounded Capacitors
Iqbal A. Khan
2002-01-01
capacitors in the realisation of continuous time filters lend to electronic tunability and compatibility to integration in contemporary IC technologies. The generalised impedance converters are also verified using PSPICE-based simulation.
Brain Mechanisms of Altered Consciousness in Generalised Seizures
Stefano Seri
2011-01-01
Full Text Available In spite of the inherent difficulties in achieving a biologically meaningful definition of consciousness, recent neurophysiological studies are starting to provide some insight in fundamental mechanisms associated with impaired consciousness in neurological disorders. Generalised seizures are associated with disruption of the default state network, a functional network of discrete brain areas, which include the fronto-parietal cortices. Subcortical contribution through activation of thalamocortical structures, as well as striate nuclei are also crucial to produce impaired consciousness in generalised seizures.
XLISP-Stat Tools for Building Generalised Estimating Equation Models
Thomas Lumley
1996-12-01
Full Text Available This paper describes a set of Lisp-Stat tools for building Generalised Estimating Equation models to analyse longitudinal or clustered measurements. The user interface is based on the built-in regression and generalised linear model prototypes, with the addition of object-based error functions, correlation structures and model formula tools. Residual and deletion diagnostic plots are available on the cluster and observation level and use the dynamic graphics capabilities of Lisp-Stat.
Mutation classes of skew-symmetrizable 3x3 matrices
Seven, Ahmet
2010-01-01
In this paper, we determine representatives for the mutation classes of skew-symmetrizable 3x3 matrices and associated graphs using a natural minimality condition, generalizing and strengthening results of Beineke-Brustle-Hille and Felikson-Shapiro-Tumarkin. Furthermore, we obtain a new numerical invariant for the mutation operation on skew-symmetrizable matrices of arbitrary size.
Skew Littlewood-Richardson rules from Hopf algebras
Lam, Thomas; Sottile, Frank
2009-01-01
We use Hopf algebras to prove a version of the Littlewood-Richardson formula for skew Schur functions, which implies a conjecture of Assaf and McNamara. We also establish a similar skew Littlewood-Richardson formula for Schur P- and Q-functions.
Gc protein (vitamin D-binding protein): Gc genotyping and GcMAF precursor activity.
Nagasawa, Hideko; Uto, Yoshihiro; Sasaki, Hideyuki; Okamura, Natsuko; Murakami, Aya; Kubo, Shinichi; Kirk, Kenneth L; Hori, Hitoshi
2005-01-01
The Gc protein (human group-specific component (Gc), a vitamin D-binding protein or Gc globulin), has important physiological functions that include involvement in vitamin D transport and storage, scavenging of extracellular G-actin, enhancement of the chemotactic activity of C5a for neutrophils in inflammation and macrophage activation (mediated by a GalNAc-modified Gc protein (GcMAF)). In this review, the structure and function of the Gc protein is focused on especially with regard to Gc genotyping and GcMAF precursor activity. A discussion of the research strategy "GcMAF as a target for drug discovery" is included, based on our own research.
On the Construction of Skew Quasi-Cyclic Codes
Abualrub, Taher; Aydin, Nuh; Siap, Irfan
2008-01-01
In this paper we study a special type of quasi-cyclic (QC) codes called skew QC codes. This set of codes is constructed using a non-commutative ring called the skew polynomial rings $F[x;\\theta ]$. After a brief description of the skew polynomial ring $F[x;\\theta ]$ it is shown that skew QC codes are left submodules of the ring $R_{s}^{l}=(F[x;\\theta ]/(x^{s}-1))^{l}.$ The notions of generator and parity-check polynomials are given. We also introduce the notion of similar polynomials in the ring $F[x;\\theta ]$ and show that parity-check polynomials for skew QC codes are unique up to similarity. Our search results lead to the construction of several new codes with Hamming distances exceeding the Hamming distances of the previously best known linear codes with comparable parameters.
How Small Is Big: Sample Size and Skewness.
Piovesana, Adina; Senior, Graeme
2016-09-21
Sample sizes of 50 have been cited as sufficient to obtain stable means and standard deviations in normative test data. The influence of skewness on this minimum number, however, has not been evaluated. Normative test data with varying levels of skewness were compiled for 12 measures from 7 tests collected as part of ongoing normative studies in Brisbane, Australia. Means and standard deviations were computed from sample sizes of 10 to 100 drawn with replacement from larger samples of 272 to 973 cases. The minimum sample size was determined by the number at which both mean and standard deviation estimates remained within the 90% confidence intervals surrounding the population estimates. Sample sizes of greater than 85 were found to generate stable means and standard deviations regardless of the level of skewness, with smaller samples required in skewed distributions. A formula was derived to compute recommended sample size at differing levels of skewness.
Characteristic functions of scale mixtures of multivariate skew-normal distributions
Kim, Hyoung-Moon
2011-08-01
We obtain the characteristic function of scale mixtures of skew-normal distributions both in the univariate and multivariate cases. The derivation uses the simple stochastic relationship between skew-normal distributions and scale mixtures of skew-normal distributions. In particular, we describe the characteristic function of skew-normal, skew-t, and other related distributions. © 2011 Elsevier Inc.
Real quartic surfaces containing 16 skew lines
Isidro Nieto
2004-01-01
Full Text Available It is well known that there is an open three-dimensional subvariety Ms of the Grassmannian of lines in ℙ3 which parametrizes smooth irreducible complex surfaces of degree 4 which are Heisenberg invariant, and each quartic contains 32 lines but only 16 skew lines, being determined by its configuration of lines, are called a double 16. We consider here the problem of visualizing in a computer the real Heisenberg invariant quartic surface and the real double 16. We construct a family of points l∈Ms parametrized by a two-dimensional semialgebraic variety such that under a change of coordinates of l into its Plüecker, coordinates transform into the real coordinates for a line L in ℙ3, which is then used to construct a program in Maple 7. The program allows us to draw the quartic surface and the set of transversal lines to L. Additionally, we include a table of a group of examples. For each test example we specify a parameter, the viewing angle of the image, compilation time, and other visual properties of the real surface and its real double 16. We include at the end of the paper an example showing the surface containing the double 16.
Nilradicals of skew Hurwitz series of rings
Morteza Ahmadi
2015-05-01
Full Text Available For a ring endomorphism α of a ring R, Krempa called α a rigid endomorphism if aα(a=0 implies a = 0 for a in R. A ring R is called rigid if there exists a rigid endomorphism of R. In this paper, we extend the α-rigid property of a ring R to the upper nilradical N_r(R of R. For an endomorphism α and the upper nilradical N_r(R of a ring R, we introduce the condition (*: N_r(R is a α-ideal of R and aα(a in N_r(R implies a in N_r(R for a in R. We study characterizations of a ring R with an endomorphism α satisfying the condition (*, and we investigate their related properties. The connections between the upper nilradical of R and the upper nilradical of the skew Hurwitz series ring (HR,α of R are also investigated.
Seismic response of skewed RC box-girder bridges
Ahmed Abdel-Mohti; Gokhan Pekcan
2008-01-01
It is critical to ensure the functionality of highway bridges after earthquakes to provide access to important facilities.Since the 1971 San Fernando earthquake,there has been a better understanding of the seismic performance of bridges.Nonetheless,there are no detailed guidelines addressing the performance of skewed highway bridges.Several parameters affect the response of skewed highway bridges under both service and seismic loads which makes their behavior complex.Therefore,there is a need for more research to study the effect of skew angle and other related factors on the performance of highway bridges.This paper examines the seismic performance of a three-span continuous concrete box girder bridge with skew angles from 0 to 60 degrees,analytically.Finite element (FE) and simplified beam-stick (BS) models of the bridge were developed using SAP2000.Different types of analysis were considered on both models such as:nonlinear static pushover,and linear and nonlinear time history analyses.A comparison was conducted between FE and BS,different skew angles,abutment support conditions,and time history and pushover analysis.It is shown that the BS model has the capability to capture the coupling due to skew and the significant modes for moderate skew angles.Boundary conditions and pushover load profile are determined to have a major effect on pushover analysis.Pushover analysis may be used to predict the maximum deformation and hinge formation adequately.
Utility functions predict variance and skewness risk preferences in monkeys.
Genest, Wilfried; Stauffer, William R; Schultz, Wolfram
2016-07-26
Utility is the fundamental variable thought to underlie economic choices. In particular, utility functions are believed to reflect preferences toward risk, a key decision variable in many real-life situations. To assess the validity of utility representations, it is therefore important to examine risk preferences. In turn, this approach requires formal definitions of risk. A standard approach is to focus on the variance of reward distributions (variance-risk). In this study, we also examined a form of risk related to the skewness of reward distributions (skewness-risk). Thus, we tested the extent to which empirically derived utility functions predicted preferences for variance-risk and skewness-risk in macaques. The expected utilities calculated for various symmetrical and skewed gambles served to define formally the direction of stochastic dominance between gambles. In direct choices, the animals' preferences followed both second-order (variance) and third-order (skewness) stochastic dominance. Specifically, for gambles with different variance but identical expected values (EVs), the monkeys preferred high-variance gambles at low EVs and low-variance gambles at high EVs; in gambles with different skewness but identical EVs and variances, the animals preferred positively over symmetrical and negatively skewed gambles in a strongly transitive fashion. Thus, the utility functions predicted the animals' preferences for variance-risk and skewness-risk. Using these well-defined forms of risk, this study shows that monkeys' choices conform to the internal reward valuations suggested by their utility functions. This result implies a representation of utility in monkeys that accounts for both variance-risk and skewness-risk preferences.
Will Edwards
Full Text Available Among co-occurring species, values for functionally important plant traits span orders of magnitude, are uni-modal, and generally positively skewed. Such data are usually log-transformed "for normality" but no convincing mechanistic explanation for a log-normal expectation exists. Here we propose a hypothesis for the distribution of seed masses based on generalised extreme value distributions (GEVs, a class of probability distributions used in climatology to characterise the impact of event magnitudes and frequencies; events that impose strong directional selection on biological traits. In tests involving datasets from 34 locations across the globe, GEVs described log10 seed mass distributions as well or better than conventional normalising statistics in 79% of cases, and revealed a systematic tendency for an overabundance of small seed sizes associated with low latitudes. GEVs characterise disturbance events experienced in a location to which individual species' life histories could respond, providing a natural, biological explanation for trait expression that is lacking from all previous hypotheses attempting to describe trait distributions in multispecies assemblages. We suggest that GEVs could provide a mechanistic explanation for plant trait distributions and potentially link biology and climatology under a single paradigm.
On the bilinear structure associated to the skew Bezoutian
Jouve, Florent
2010-01-01
Let (p,q) be a couple of reciprocal (resp. q is reciprocal and p is skew-reciprocal) coprime polynomials of degree d over a field with characteristic not 2.To such a couple we can associate a non-singular antisymmetric (resp. symmetric) matrix of size d, which we call the skew Bezoutian. In this paper we study some properties of the corresponding symplectic (resp. quadratic) space. Using the skew Bezoutian we construct explicit isometries of bilinear spaces with given invariants (such as the characteristic polynomial or Jordan form and, in the quadratic case, the spinor norm).
Differences of Skew Schur Functions of Staircases with Transposed Foundations
Morin, Matthew
2010-01-01
We consider the skew diagram $\\Delta_n$, which is the $180^\\circ$ rotation of the staircase diagram $\\delta_n = (n,n-1,n-2,...,2,1)$. We create a staircase with bad foundation by augmenting $\\Delta_n$ with another skew diagram, which we call the \\textit{foundation}. We consider pairs of staircases with bad foundation whose foundations are transposes of one another. Among these pairs, we show that the difference of the corresponding skew Schur functions is Schur-positive in the case when one of the foundations consists of either a one or two row diagram, or a hook diagram.
Marcio Pozzobon Pedroso
2009-01-01
Full Text Available This paper presents the fundamental principles, instrumentation and selected applications of comprehensive two-dimensional gas chromatography (GC × GC. In this technique, introduced in 1991, two capillary columns are coupled and proper modulating interfaces continuously collect the eluate from the first column, transferring it to the second column. The result is a geometric increment in the chromatographic resolution, ensuring separation of extremely complex mixtures in time periods shorter or comparable to those of analysis using conventional gas chromatography and with better detectabilities and sensitivities.
Generalised Cesaro Convergence, Root Identities and the Riemann Hypothesis
Stone, Richard
2011-01-01
We extend the notion of generalised Cesaro summation/convergence developed previously to the more natural setting of what we call "remainder" Cesaro summation/convergence and, after illustrating the utility of this approach in deriving certain classical results, use it to develop a notion of generalised root identities. These extend elementary root identities for polynomials both to more general functions and to a family of identities parametrised by a complex parameter \\mu. In so doing they equate one expression (the derivative side) which is defined via Fourier theory, with another (the root side) which is defined via remainder Cesaro summation. For \\mu a non-positive integer these identities are naturally adapted to investigating the asymptotic behaviour of the given function and the geometric distribution of its roots. For the Gamma function we show that it satisfies the generalised root identities and use them to constructively deduce Stirling's theorem. For the Riemann zeta function the implications of ...
Object recognition and generalisation during habituation in horses
Christensen, Janne Winther; Zharkikh, Tjatjana; Chovaux, Elodie
2011-01-01
.e. testing for object recognition) and ii) a novel object (new shape and colour, i.e. testing for object generalisation), compared to CONTROLS. In the second experiment we investigated whether TEST horses reacted to a change in object order and object location. Behavioural reactions to the object, latency...... to eat, total eating time and heart rate were recorded. Compared to CONTROLS, TEST horses reacted significantly less towards objects, which were previously part of the complex object (e.g. mean heart rate; P = 0.006), indicating object recognition. In contrast to our expectations, TEST horses also...... for object generalisation (Christensen et al., 2008). In a series of experiments, we aimed to further explore the ability of horses (n = 30, 1 and 2-year-old mares) to recognise and generalise between objects during habituation. TEST horses (n = 15) were habituated to a complex object, composed of five...
Generalised Brown Clustering and Roll-up Feature Generation
Derczynski, Leon; Chester, Sean
2016-01-01
Brown clustering is an established technique, used in hundreds of computational linguistics papers each year, to group word types that have similar distributional information. It is unsupervised and can be used to create powerful word representations for machine learning. Despite its improbable...... success relative to more complex methods, few have investigated whether Brown clustering has really been applied optimally. In this paper, we present a subtle but profound generalisation of Brown clustering to improve the overall quality by decoupling the number of output classes from the computational...... active set size. Moreover, the generalisation permits a novel approach to feature selection from Brown clusters: We show that the standard approach of shearing the Brown clustering output tree at arbitrary bitlengths is lossy and that features should be chosen instead by rolling up Generalised Brown...
The Generalised Discrete Algebraic Riccati Equation in LQ optimal control
Ferrante, Augusto
2012-01-01
This paper investigates the properties of the solutions of the generalised discrete algebraic Riccati equation arising from the solution of the classic infinite-horizon linear quadratic control problem. In particular, a geometric analysis is used to study the relationship existing between the solutions of the generalised Riccati equation and the output-nulling subspaces of the underlying system and the corresponding reachability subspaces. This analysis reveals the presence of a subspace that plays an important role in the solution of the related optimal control problem, which is reflected in the generalised eigenstructure of the corresponding extended symplectic pencil. In establishing themain results of this paper, several ancillay problems on the discrete Lyapunov equation and spectral factorisation are also addressed and solved.
Lepton Mixing Predictions from (Generalised) CP and Discrete Flavour Symmetry
Neder, Thomas
2015-01-01
An important class of flavour groups, that are subgroups of $U(3)$ and that predict experimentally viable lepton mixing parameters including Majorana phases, is the $\\Delta(6n^2)$ series. The most well-known member is $\\Delta(24)=S_4$. I present results of several extensive studies of lepton mixing predictions obtained in models with a $\\Delta(6n^2)$ flavour group that preserve either the full residual $Z_2\\times Z_2$ or a $Z_2$ subgroup for neutrinos and can include a generalised CP symmetry. Predictions include mixing angles and Dirac CP phase generally; and if invariance under a generalised CP symmetry is included, also Majorana phases. For this, the interplay of flavour group and generalised CP symmetry has to be studied carefully.
Patterns of paternity skew among polyandrous social insects
Jaffé, Rodolfo; Garcia-Gonzalez, Francisco; den Boer, Susanne;
2012-01-01
Monogamy results in high genetic relatedness among offspring and thus it is generally assumed to be favored by kin selection. Female multiple mating (polyandry) has nevertheless evolved several times in the social Hymenoptera (ants, bees, and wasps), and a substantial amount of work has been...... conducted to understand its costs and benefits. Relatedness and inclusive fitness benefits are, however, not only influenced by queen mating frequency but also by paternity skew, which is a quantitative measure of paternity biases among the offspring of polyandrous females. We performed a large......-scale phylogenetic analysis of paternity skew across polyandrous social Hymenoptera. We found a general and significant negative association between paternity frequency and paternity skew. High paternity skew, which increases relatedness among colony members and thus maximizes inclusive fitness gains, characterized...
Systems of Differential Equations with Skew-Symmetric, Orthogonal Matrices
Glaister, P.
2008-01-01
The solution of a system of linear, inhomogeneous differential equations is discussed. The particular class considered is where the coefficient matrix is skew-symmetric and orthogonal, and where the forcing terms are sinusoidal. More general matrices are also considered.
Although Relatively Few, "Doctor Shoppers" Skew Opioid Prescribing
... Opioid Prescribing Although Relatively Few, “Doctor Shoppers” Skew Opioid Prescribing Email Facebook Twitter May 27, 2014 One ... patterns and alert both physicians and pharmacies. Extreme Opioid Purchasers Figure 1. Prescriber Utilization Distinguishes Likely “Doctor ...
Systems of Differential Equations with Skew-Symmetric, Orthogonal Matrices
Glaister, P.
2008-01-01
The solution of a system of linear, inhomogeneous differential equations is discussed. The particular class considered is where the coefficient matrix is skew-symmetric and orthogonal, and where the forcing terms are sinusoidal. More general matrices are also considered.
Sickle Cell Trait in Blacks Can Skew Diabetes Test Results
... page: https://medlineplus.gov/news/fullstory_163463.html Sickle Cell Trait in Blacks Can Skew Diabetes Test Results ... less accurate in black people who have the sickle cell anemia trait, a new study says. The test ...
PRINCIPLE OF SKEW QUADRUPOLE MODULATION TO MEASURE BETATRON COUPLING.
LUO.Y.PILAT,F.ROSER,T.ET AL.
2004-07-05
The measurement of the residual betatron coupling via skew quadrupole modulation is a new diagnostics technique that has been developed and tested at the Relativistic Heavy Ion Collider (RHIC) as a very promising method for the linear decoupling on the ramp. By modulating the strengths of different skew quadrupole families the two eigentunes are precisely measured with the phase lock loop system. The projections of the residual coupling coefficient onto the skew quadrupole coupling modulation directions are determined. The residual linear coupling could be corrected according to the measurement. An analytical solution for skew quadrupole modulation based on Hamiltonian perturbation approximation is given, and simulation code using smooth accelerator model is also developed. Some issues concerning the practical applications of this technique are discussed.
Maximal supports and Schur-positivity among connected skew shapes
McNamara, Peter R W
2011-01-01
The Schur-positivity order on skew shapes is defined by B \\leq A if the difference s_A - s_B is Schur-positive. It is an open problem to determine those connected skew shapes that are maximal with respect to this ordering. A strong sufficient condition for the Schur-positivity of s_A - s_B is that the support of B is contained in that of A, where the support of B is defined to be the set of partitions lambda for which s_lambda appears in the Schur expansion of s_B. We show that to determine the maximal connected skew shapes in the Schur-positivity order and this support containment order, it suffices to consider a special class of ribbon shapes. We explicitly determine the support for these ribbon shapes, thereby determining the maximal connected skew shapes in the support containment order.
Generalisation of new sequence knowledge depends on response modality.
Clive R Rosenthal
Full Text Available New visuomotor skills can guide behaviour in novel situations. Prior studies indicate that learning a visuospatial sequence via responses based on manual key presses leads to effector- and response-independent knowledge. Little is known, however, about the extent to which new sequence knowledge can generalise, and, thereby guide behaviour, outside of the manual response modality. Here, we examined whether learning a visuospatial sequence either via manual (key presses, without eye movements, oculomotor (obligatory eye movements, or perceptual (covert reorienting of visuospatial attention responses supported generalisation to direct and indirect tests administered either in the same (baseline conditions or a novel response modality (transfer conditions with respect to initial study. Direct tests measured the use of conscious knowledge about the studied sequence, whereas the indirect tests did not ostensibly draw on the study phase and measured response priming. Oculomotor learning supported the use of conscious knowledge on the manual direct tests, whereas manual learning supported generalisation to the oculomotor direct tests but did not support the conscious use of knowledge. Sequence knowledge acquired via perceptual responses did not generalise onto any of the manual tests. Manual, oculomotor, and perceptual sequence learning all supported generalisation in the baseline conditions. Notably, the manual baseline condition and the manual to oculomotor transfer condition differed in the magnitude of general skill acquired during the study phase; however, general skill did not predict performance on the post-study tests. The results demonstrated that generalisation was only affected by the responses used to initially code the visuospatial sequence when new knowledge was applied to a novel response modality. We interpret these results in terms of response-effect distinctiveness, the availability of integrated effector- and motor-plan based
Adaptive optimisation of a generalised phase contrast beam shaping system
Kenny, F.; Choi, F. S.; Glückstad, J.; Booth, M. J.
2015-05-01
The generalised phase contrast (GPC) method provides versatile and efficient light shaping for a range of applications. We have implemented a generalised phase contrast system that used two passes on a single spatial light modulator (SLM). Both the pupil phase distribution and the phase contrast filter were generated by the SLM. This provided extra flexibility and control over the parameters of the system including the phase step magnitude, shape, radius and position of the filter. A feedback method for the on-line optimisation of these properties was also developed. Using feedback from images of the generated light field, it was possible to dynamically adjust the phase filter parameters to provide optimum contrast.
Thoracic involvement in generalised lymphatic anomaly (or lymphangiomatosis
Francesca Luisi
2016-06-01
Full Text Available Generalised lymphatic anomaly (GLA, also known as lymphangiomatosis, is a rare disease caused by congenital abnormalities of lymphatic development. It usually presents in childhood but can also be diagnosed in adults. GLA encompasses a wide spectrum of clinical manifestations ranging from single-organ involvement to generalised disease. Given the rarity of the disease, most of the information regarding it comes from case reports. To date, no clinical trials concerning treatment are available. This review focuses on thoracic GLA and summarises possible diagnostic and therapeutic approaches.
The affective impact of financial skewness on neural activity and choice.
Wu, Charlene C; Bossaerts, Peter; Knutson, Brian
2011-02-15
Few finance theories consider the influence of "skewness" (or large and asymmetric but unlikely outcomes) on financial choice. We investigated the impact of skewed gambles on subjects' neural activity, self-reported affective responses, and subsequent preferences using functional magnetic resonance imaging (FMRI). Neurally, skewed gambles elicited more anterior insula activation than symmetric gambles equated for expected value and variance, and positively skewed gambles also specifically elicited more nucleus accumbens (NAcc) activation than negatively skewed gambles. Affectively, positively skewed gambles elicited more positive arousal and negatively skewed gambles elicited more negative arousal than symmetric gambles equated for expected value and variance. Subjects also preferred positively skewed gambles more, but negatively skewed gambles less than symmetric gambles of equal expected value. Individual differences in both NAcc activity and positive arousal predicted preferences for positively skewed gambles. These findings support an anticipatory affect account in which statistical properties of gambles--including skewness--can influence neural activity, affective responses, and ultimately, choice.
Extension of EMA to address regional skew and low outliers
Griffis, V.W.; Stedinger, J.R.; Cohn, T.A.; Bizier, P.; DeBarry, P.
2003-01-01
The recently developed expected moments algorithm [EMA] (Cohn et al. 1997) does as well as MLEs at estimating LP3 flood quantiles using systematic and historical information. Needed extensions include use of a regional skewness estimator and its precision to be consistent with Bulletin 17B and to make use of such hydrologic information. Another issue addressed by Bulletin 17B is the treatment of low outliers. A Monte Carlo study illustrates the performance of an extended EMA estimator compared to estimators that employ the complete data set with and without use of regional skew, conditional probability adjustment from Bulletin 17B, and an estimator that uses probability plot regression to compute substitute values for low outliers. Estimators that use a regional skew all do better than estimators that fail to use an informative regional skewness estimator. For LP3 data, the low outlier rejection procedure results in no loss of overall accuracy, and the differences between the MSEs of the estimators that used an informative regional skew were generally negligible in the skew range of real interest.
Multivariate extended skew-t distributions and related families
Arellano-Valle, Reinaldo B.
2010-12-01
A class of multivariate extended skew-t (EST) distributions is introduced and studied in detail, along with closely related families such as the subclass of extended skew-normal distributions. Besides mathematical tractability and modeling flexibility in terms of both skewness and heavier tails than the normal distribution, the most relevant properties of the EST distribution include closure under conditioning and ability to model lighter tails as well. The first part of the present paper examines probabilistic properties of the EST distribution, such as various stochastic representations, marginal and conditional distributions, linear transformations, moments and in particular Mardia’s measures of multivariate skewness and kurtosis. The second part of the paper studies statistical properties of the EST distribution, such as likelihood inference, behavior of the profile log-likelihood, the score vector and the Fisher information matrix. Especially, unlike the extended skew-normal distribution, the Fisher information matrix of the univariate EST distribution is shown to be non-singular when the skewness is set to zero. Finally, a numerical application of the conditional EST distribution is presented in the context of confidential data perturbation.
Skewed X inactivation in Lesch-Nyhan disease carrier females.
Torres, Rosa J; Puig, Juan G
2017-09-14
X chromosome inactivation (XCI) ratios of normal females can range from a highly skewed ratio of 0:100 to a 50:50 ratio. In several X-linked disorders, female carriers present skewed X inactivation. Hypoxanthine-guanine phosphoribosyltransferase (HPRT) deficiency is an X-linked disorder. Males are affected and present with the complete Lesch-Nyhan disease (LND) or with a partial phenotype (Lesch-Nyhan variant, LNV). Female carriers are usually asymptomatic. The aim of the present study was to analyze the XCI pattern of HPRT-deficiency carrier females. As a group, 75% of HPRT-deficiency carrier females presented skewed XCI. Moreover, skewed XCI is significantly more frequent in LND carriers (83%) than in LNV (0-50%, depending on the phenotype severity). The ratios of the preferentially inactivated allele of carrier females were significantly higher than the ratios of the preferentially inactivated allele of noncarrier females (89.4±15, n=52 vs 65.2±12, n=52; P<0.0001). For carrier diagnosis, the presence of skewed XCI presents a sensitivity of 75% with a specificity of 85%. In LND families, the presence of skewed XCI is more sensitive for carrier diagnosis than in LNV families; however, we believe that this test is not accurate for carrier diagnostic purposes.Journal of Human Genetics advance online publication, 14 September 2017; doi:10.1038/jhg.2017.88.
Adapting Metacognitive Therapy to Children with Generalised Anxiety Disorder
Esbjørn, Barbara Hoff; Normann, Nicoline; Reinholdt-Dunne, Marie Louise
2015-01-01
-c) with generalised anxiety disorder (GAD) and create suggestions for an adapted manual. The adaptation was based on the structure and techniques used in MCT for adults with GAD. However, the developmental limitations of children were taken into account. For instance, therapy was aided with worksheets, practical...
Generalised functions and distributional curvature of cosmic strings
Clarke, C J S; Wilson, J P
1996-01-01
A new method is presented for assigning distributional curvature, in an invariant manner, to a space-time of low differentiability, using the techniques of Colombeau's `new generalised functions'. The method is applied to show that curvature of a cone is equivalent to a delta function. The same is true under small enough perturbations.
Generalised time functions and finiteness of the Lorentzian distance
Rennie, Adam
2014-01-01
We show that finiteness of the Lorentzian distance is equivalent to the existence of generalised time functions with gradient uniformly bounded away from light cones. To derive this result we introduce new techniques to construct and manipulate achronal sets. As a consequence of these techniques we obtain a functional description of the Lorentzian distance extending the work of Franco and Moretti.
Metacognitive, Cognitive and Developmental Predictors of Generalised Anxiety Disorder Symptoms
Tan, Shary; Moulding, Richard; Nedeljkovic, Maja; Kyrios, Michael
2010-01-01
Generalised anxiety disorder (GAD) is the most significant and common of the anxiety disorders. Intolerance of uncertainty (IU) and negative metacognitive beliefs are two prominent cognitive factors in models of GAD, however only one study to date has examined the relative contribution of these factors. Therefore, this study aimed to investigate…
Certain Generalisations of Bartholomew's Problem in Life Testing
T. N. Srivastava
1971-10-01
Full Text Available Certain generalisations of the Bartholomew's problem in Life testing have been discussed namely when a number of items are placed on test at different times, when the life of times follows normal distribution and when items with two components are placed on test.
Autobiographical memory in children with Idiopathic Generalised Epilepsy.
Gascoigne, Michael B; Barton, Belinda; Webster, Richard; Gill, Deepak; Lah, Suncica
2015-01-01
Autobiographical memory involves the recall of both personal facts (semantic memory) and the re-experiencing of past personal events (episodic memory). The recall of autobiographical episodic details has been associated with a specific network, which involves the prefrontal and medial temporal lobes, in addition to posterior regions of the brain. Seizure activity has been previously shown to disrupt the consolidation of newly-learned information into long-term memory, but it is not yet known whether primary generalised seizures alone are also associated with deficits in the recall of autobiographical memories. Here we examined this recall in children who experience generalised rather than localisation-related seizures: children with Idiopathic Generalised Epilepsy (IGE). In this study, 18 children with IGE and 42 healthy controls of comparable age (6-16 years), sex and socio-economic status were administered the Children's Autobiographical Interview (CAI). Compared with controls, children with IGE recalled significantly fewer episodic details, even when retrieval prompts were provided. In contrast, no group difference was found for the recall of semantic autobiographic details. Within the IGE group, hierarchical regression analyses showed that patient age and earlier age of diagnosis were significantly related to the recall of episodic autobiographical details over different conditions of the CAI, explaining up to 37% of variance. To our knowledge, this study provides the first evidence of autobiographical episodic memory deficits in patients with primary generalised seizures. As no evidence of localisation-related epilepsy is apparent in patients with IGE, our findings suggest that generalised seizures alone, especially when developed at an early age, could compromise memories for personally-experienced events.
Asymptotic Distribution of Coefficients of Skewness and Kurtosis
Narges Abbasi
2009-01-01
Full Text Available Problem statement: In literature, a classic method which has been used to recognize the distribution so far is the measurement of its skewedness and kurtosis. However, there remains a question: how would these measurements work for skewed normal distribution when the size of the sample is large? Approach: This research aimed to determine the asymptotic distribution of skewedness and kurtosis measures in skewed normal distribution. In conducting this research, two groups of inferential findings will help. First, skewed normal distribution which has already been studied by a lot of researchers and we apply its characteristics. Second, there is the U-statistics theory which guides us to the determining of asymptotic distribution measures for skewedness and kurtosis. The combination of these two will solve the problem of this study. Results: Asymptotic distribution of measures for skewdness and kurtosis falls in the normal families. With the size of large samples, the values of expectation of these measures are also determined. By letting zero for skewedness parameter, asymptotic distribution for normal distribution can also be obtained. Conclusion: The findings of this study show new characteristics for skew normal distribution and this results in a new way for skew normal distribution recognition.
On river-floodplain interaction and hydrograph skewness
Fleischmann, Ayan S.; Paiva, Rodrigo C. D.; Collischonn, Walter; Sorribas, Mino V.; Pontes, Paulo R. M.
2016-10-01
Understanding hydrological processes occurring within a basin by looking at its outlet hydrograph can improve and foster comprehension of ungauged regions. In this context, we present an extensive examination of the roles that floodplains play on driving hydrograph shapes. Observations of many river hydrographs with large floodplain influence are carried out and indicate that a negative skewness of the hydrographs is present among many of them. Through a series of numerical experiments and analytical reasoning, we show how the relationship between flood wave celerity and discharge in such systems is responsible for determining the hydrograph shapes. The more water inundates the floodplains upstream of the observed point, the more negatively skewed is the observed hydrograph. A case study is performed in the Amazon River Basin, where major rivers with large floodplain attenuation (e.g., Purus, Madeira, and Juruá) are identified with higher negative skewness in the respective hydrographs. Finally, different wetland types could be distinguished by using this feature, e.g., wetlands maintained by endogenous processes, from wetlands governed by overbank flow (along river floodplains). A metric of hydrograph skewness was developed to quantify this effect, based on the time derivative of discharge. Together with the skewness concept, it may be used in other studies concerning the relevance of floodplain attenuation in large, ungauged rivers, where remote sensing data (e.g., satellite altimetry) can be very useful.
Isomorphic Operators and Functional Equations for the Skew-Circulant Algebra
Zhaolin Jiang
2014-01-01
Full Text Available The skew-circulant matrix has been used in solving ordinary differential equations. We prove that the set of skew-circulants with complex entries has an idempotent basis. On that basis, a skew-cyclic group of automorphisms and functional equations on the skew-circulant algebra is introduced. And different operators on linear vector space that are isomorphic to the algebra of n×n complex skew-circulant matrices are displayed in this paper.
Skew Schur Functions of Sums of Fat Staircases
Morin, Matthew
2010-01-01
We define a fat staircase to be a Ferrers diagram corresponding to a partition of the form $(n^{\\alpha_n}, {n-1}^{\\alpha_{n-1}},..., 1^{\\alpha_1})$, where $\\alpha = (\\alpha_1,...,\\alpha_n)$ is a composition, or the $180^\\circ$ rotation of such a diagram. If a diagram's skew Schur function is a linear combination of Schur functions of fat staircases, we call the diagram a sum of fat staircases. We prove a Schur-positivity result that is obtained each time we augment a sum of fat staircases with a skew diagram. We also determine conditions on which diagrams can be sums of fat staircases, including necessary and sufficient conditions in the special case when the diagram is a fat staircase skew a single row or column.
Adjunctions between Boolean spaces and skew Boolean algebras
Kudryavtseva, Ganna
2011-01-01
We apply the representation theory of left-handed skew Boolean algebras by sections of their dual \\'{e}tale spaces, given in \\cite{K}, to construct a series of dual adjunctions between the categories of locally compact Boolean spaces and left-handed skew Boolean algebras by means of extensions of certain enriched $\\Hom$-set functors induced by objects sitting in two categories. The constructed adjunctions are "deformations" of Stone duality obtained by the replacement in the latter of the category of Boolean algebras by the category of left-handed skew Boolean algebras. The constructions provide natural settings for the $\\omega$-functor constructed in \\cite{LS} and its left adjoint functor.
Speckles generated by skewed, short-coherence light beams
Brogioli, D; Croccolo, F; Ziano, R; Mantegazza, F
2011-01-01
When a coherent laser beam impinges on a random sample (e.g. a colloidal suspension), the scattered light exhibits characteristic speckles. If the temporal coherence of the light source is too short, then the speckles disappear, along with the possibility of performing homodyne or heterodyne scattering detection or photon correlation spectroscopy. Here we investigate the scattering of a so-called "skewed coherence beam", i.e., a short-coherence beam modified such that the field is coherent within slabs that are skewed with respect to the wave fronts. We show that such a beam generates speckles and can be used for heterodyne scattering detection, despite its short temporal coherence. When applied to quite turbid samples, the technique has the remarkable advantage of suppressing the multiple scattering contribution of the scattering signal. The phenomenon presented here represents a very effective method for measuring the coherence skewness of either a continuous wave or a pulsed beam. Another field of applicat...
Performance Analyses of IDEAL Algorithm on Highly Skewed Grid System
Dongliang Sun
2014-03-01
Full Text Available IDEAL is an efficient segregated algorithm for the fluid flow and heat transfer problems. This algorithm has now been extended to the 3D nonorthogonal curvilinear coordinates. Highly skewed grids in the nonorthogonal curvilinear coordinates can decrease the convergence rate and deteriorate the calculating stability. In this study, the feasibility of the IDEAL algorithm on highly skewed grid system is analyzed by investigating the lid-driven flow in the inclined cavity. It can be concluded that the IDEAL algorithm is more robust and more efficient than the traditional SIMPLER algorithm, especially for the highly skewed and fine grid system. For example, at θ = 5° and grid number = 70 × 70 × 70, the convergence rate of the IDEAL algorithm is 6.3 times faster than that of the SIMPLER algorithm, and the IDEAL algorithm can converge almost at any time step multiple.
Uniqueness: skews bit occurrence frequencies in randomly generated fingerprint libraries.
Chen, Nelson G
2016-08-01
Requiring that randomly generated chemical fingerprint libraries have unique fingerprints such that no two fingerprints are identical causes a systematic skew in bit occurrence frequencies, the proportion at which specified bits are set. Observed frequencies (O) at which each bit is set within the resulting libraries systematically differ from frequencies at which bits are set at fingerprint generation (E). Observed frequencies systematically skew toward 0.5, with the effect being more pronounced as library size approaches the compound space, which is the total number of unique possible fingerprints given the number of bit positions each fingerprint contains. The effect is quantified for varying library sizes as a fraction of the overall compound space, and for changes in the specified frequency E. The cause and implications for this systematic skew are subsequently discussed. When generating random libraries of chemical fingerprints, the imposition of a uniqueness requirement should either be avoided or taken into account.
Determining collective barrier operation skew in a parallel computer
Faraj, Daniel A.
2015-11-24
Determining collective barrier operation skew in a parallel computer that includes a number of compute nodes organized into an operational group includes: for each of the nodes until each node has been selected as a delayed node: selecting one of the nodes as a delayed node; entering, by each node other than the delayed node, a collective barrier operation; entering, after a delay by the delayed node, the collective barrier operation; receiving an exit signal from a root of the collective barrier operation; and measuring, for the delayed node, a barrier completion time. The barrier operation skew is calculated by: identifying, from the compute nodes' barrier completion times, a maximum barrier completion time and a minimum barrier completion time and calculating the barrier operation skew as the difference of the maximum and the minimum barrier completion time.
Market skewness risk and the cross section of stock returns
Chang, B.Y.; Christoffersen, Peter; Jacobs, K.
2013-01-01
The cross section of stock returns has substantial exposure to risk captured by higher moments of market returns. We estimate these moments from daily Standard & Poor's 500 index option data. The resulting time series of factors are genuinely conditional and forward-looking. Stocks with high...... exposure to innovations in implied market skewness exhibit low returns on average. The results are robust to various permutations of the empirical setup. The market skewness risk premium is statistically and economically significant and cannot be explained by other common risk factors such as the market...... excess return or the size, book-to-market, momentum, and market volatility factors, or by firm characteristics....
Strong skew commutativity preserving maps on von Neumann algebras
Qi, Xiaofei
2012-01-01
Let ${\\mathcal M}$ be a von Neumann algebra without central summands of type $I_1$. Assume that $\\Phi:{\\mathcal M}\\rightarrow {\\mathcal M}$ is a surjective map. It is shown that $\\Phi$ is strong skew commutativity preserving (that is, satisfies $\\Phi(A)\\Phi(B)-\\Phi(B)\\Phi(A)^*=AB-BA^*$ for all $A,B\\in{\\mathcal M}$) if and only if there exists some self-adjoint element $Z$ in the center of ${\\mathcal M}$ with $Z^2=I$ such that $\\Phi(A)=ZA$ for all $A\\in{\\mathcal M}$. The strong skew commutativity preserving maps on prime involution rings and prime involution algebras are also characterized.
Mixtures of Common Skew-t Factor Analyzers
Murray, Paula M.; McNicholas, Paul D.; Browne, Ryan P.
2013-01-01
A mixture of common skew-t factor analyzers model is introduced for model-based clustering of high-dimensional data. By assuming common component factor loadings, this model allows clustering to be performed in the presence of a large number of mixture components or when the number of dimensions is too large to be well-modelled by the mixtures of factor analyzers model or a variant thereof. Furthermore, assuming that the component densities follow a skew-t distribution allows robust clusterin...
Parameterizing unconditional skewness in models for financial time series
He, Changli; Silvennoinen, Annastiina; Teräsvirta, Timo
In this paper we consider the third-moment structure of a class of time series models. It is often argued that the marginal distribution of financial time series such as returns is skewed. Therefore it is of importance to know what properties a model should possess if it is to accommodate...... unconditional skewness. We consider modelling the unconditional mean and variance using models that respond nonlinearly or asymmetrically to shocks. We investigate the implications of these models on the third-moment structure of the marginal distribution as well as conditions under which the unconditional...
Skew-orthogonal polynomials, differential systems and random matrix theory
Ghosh, Saugata [Abdus Salam ICTP, Strada Costiera 11, 34100, Trieste (Italy)
2007-01-26
We study skew-orthogonal polynomials with respect to the weight function exp [ - 2V(x)], with V(x) = {sigma}{sup 2d}{sub K=1}(u{sub K}/K)x{sup K}, u{sub 2d} > 0, d > 0. A finite subsequence of such skew-orthogonal polynomials arising in the study of orthogonal and symplectic ensembles of random matrices satisfies a system of differential-difference-deformation equation. The vectors formed by such subsequence have the rank equal to the degree of the potential in the quaternion sense. These solutions satisfy certain compatibility condition and hence admit a simultaneous fundamental system of solutions.
Lucie Colineau
Full Text Available Follicular helper T (Tfh cells within secondary lymphoid organs control multiple steps of B cell maturation and antibody (Ab production. HIV-1 infection is associated with an altered B cell differentiation and Tfh isolated from lymph nodes of HIV-infected (HIV+ individuals provide inadequate B cell help in vitro. However, the mechanisms underlying this impairment of Tfh function are not fully defined. Using a unique collection of splenocytes, we compared the frequency, phenotype and transcriptome of Tfh subsets in spleens from HIV negative (HIV- and HIV+ subjects. We observed an increase of CXCR5+PD-1highCD57-Tfh and germinal center (GC CD57+ Tfh in HIV+ spleens. Both subsets showed a reduced mRNA expression of the transcription factor STAT-3, co-stimulatory, regulatory and signal transduction molecules as compared to HIV- spleens. Similarly, Foxp3 expressing follicular regulatory T (Tfr cells were increased, suggesting sustained GC reactions in chronically HIV+ spleens. As a consequence, GC B cell populations were expanded, however, complete maturation into memory B cells was reduced in HIV+ spleens where we evidenced a compromised production of B cell-activating cytokines such as IL-4 and IL-10. Collectively our data indicate that, although Tfh proliferation and GC reactions seem to be ongoing in HIV-infected spleens, Tfh "differentiation" and expression of costimulatory molecules is skewed with a profound effect on B cell maturation.
Generalising the logistic map through the q-product
Pessoa, R. W. S.; Borges, E. P.
2011-03-01
We investigate a generalisation of the logistic map as xn+1 = 1 - axn otimesqmap xn (-1 Borges, E.P. Physica A 340, 95 (2004)]. The usual product, and consequently the usual logistic map, is recovered in the limit q → 1, The tent map is also a particular case for qmap → ∞. The generalisation of this (and others) algebraic operator has been widely used within nonextensive statistical mechanics context (see C. Tsallis, Introduction to Nonextensive Statistical Mechanics, Springer, NY, 2009). We focus the analysis for qmap > 1 at the edge of chaos, particularly at the first critical point ac, that depends on the value of qmap. Bifurcation diagrams, sensitivity to initial conditions, fractal dimension and rate of entropy growth are evaluated at ac(qmap), and connections with nonextensive statistical mechanics are explored.
A plethora of generalised solitary gravity-capillary water waves
Clamond, Didier; Duran, Angel
2014-01-01
The present study describes, first, an efficient algorithm for computing gravity-capillary solitary waves solutions of the irrotational Euler equations and, second, provides numerical evidences of the existence of (likely) an infinite number of generalised solitary waves (i.e. solitary waves with undamped oscillatory wings). Using conformal mapping, the unknown fluid domain (which is to be determined) is mapped into a uniform strip of the complex plane. A Babenko-like equation is then derived from a Lagrangian expressed in the transformed domain. The Babenko equation is then solved numerically using a Levenberg-Marquardt algorithm. Various interesting solutions are computed, some of them being known, some seem to be new. The emergence of generalised solitary waves is shown when the Bond number is increased.
Generalised k-Steiner Tree Problems in Normed Planes
Brazil, Marcus; Swanepoel, Konrad J; Thomas, Doreen A
2011-01-01
The 1-Steiner tree problem, the problem of constructing a Steiner minimum tree containing at most one Steiner point, has been solved in the Euclidean plane by Georgakopoulos and Papadimitriou using plane subdivisions called oriented Dirichlet cell partitions. Their algorithm produces an optimal solution within $\\mathcal{O}(n^2)$ time. In this paper we generalise their approach in order to solve the $k$-Steiner tree problem, in which the Steiner minimum tree may contain up to $k$ Steiner points for a given constant $k$. We also extend their approach further to encompass arbitrary normed planes, and to solve a much wider class of problems, including the $k$-bottleneck Steiner tree problem and other generalised $k$-Steiner tree problems. We show that, for any fixed $k$, such problems can be solved in $\\mathcal{O}(n^{2k})$ time.
Generalised conservation laws in non-local field theories
Kegeles, Alexander
2015-01-01
We propose a geometrical treatment of symmetries in non-local field theories, where the non-locality is due to a lack of identification of field arguments in the action. We show that the existence of a symmetry of the action leads to a generalised conservation law, in which the usual conserved current acquires an additional non-local correction term, obtaining a generalisation of the standard Noether theorem. We illustrate the general formalism by discussing the specific physical example of complex scalar field theory of the type describing the hydrodynamic approximation of Bose-Einstein condensates. We expect our analysis and results to be of particular interest for the group field theory formulation of quantum gravity.
Generalised quasi-linear approximation of the HMRI
Child, Adam; Marston, Brad; Tobias, Steven
2016-01-01
Motivated by recent advances in Direct Statistical Simulation (DSS) of astrophysical phenomena such as out of equilibrium jets, we perform a Direct Numerical Simulation (DNS) of the helical magnetorotational instability (HMRI) under the generalised quasilinear approximation (GQL). This approximation generalises the quasilinear approximation (QL) to include the self-consistent interaction of large-scale modes, interpolating between fully nonlinear DNS and QL DNS whilst still remaining formally linear in the small scales. In this paper we address whether GQL can more accurately describe low-order statistics of axisymmetric HMRI when compared with QL by performing DNS under various degrees of GQL approximation. We utilise various diagnostics, such as energy spectra in addition to first and second cumulants, for calculations performed for a range of Reynolds and Hartmann numbers (describing rotation and imposed magnetic field strength respectively). We find that GQL performs significantly better than QL in descri...
A study of idiopathic generalised epilepsy in an Irish population.
Mullins, G M
2012-02-03
Idiopathic generalised epilepsy (IGE) is subdivided into syndromes based on clinical and EEG features. PURPOSE: The aim of this study was to characterise all cases of IGE with supportive EEG abnormalities in terms of gender differences, seizure types reported, IGE syndromes, family history of epilepsy and EEG findings. We also calculated the limited duration prevalence of IGE in our cohort. METHODS: Data on abnormal EEGs were collected retrospectively from two EEG databases at two tertiary referral centres for neurology. Clinical information was obtained from EEG request forms, standardised EEG questionnaires and medical notes of patients. RESULTS: two hundred twenty-three patients met our inclusion criteria, 89 (39.9%) male and 134 (60.1%) females. Tonic clonic seizures were the most common seizure type reported, 162 (72.65%) having a generalised tonic clonic seizure (GTCS) at some time. IGE with GTCS only (EGTCSA) was the most common syndrome in our cohort being present in 94 patients (34 male, 60 female), with 42 (15 male, 27 female) patients diagnosed with Juvenile myoclonic epilepsy (JME), 23 (9 male, 14 female) with Juvenile absence epilepsy (JAE) and 20 (9 male, 11 female) with childhood absence epilepsy (CAE). EEG studies in all patients showed generalised epileptiform activity. CONCLUSIONS: More women than men were diagnosed with generalised epilepsy. Tonic clonic seizures were the most common seizure type reported. EGTCSA was the most frequent syndrome seen. Gender differences were evident for JAE and JME as previously reported and for EGTCSA, which was not reported to date, and reached statistical significance for EGTCA and JME.
Generalisation of geographic information cartographic modelling and applications
Mackaness, William A; Sarjakoski, L Tiina
2011-01-01
Theoretical and Applied Solutions in Multi Scale MappingUsers have come to expect instant access to up-to-date geographical information, with global coverage--presented at widely varying levels of detail, as digital and paper products; customisable data that can readily combined with other geographic information. These requirements present an immense challenge to those supporting the delivery of such services (National Mapping Agencies (NMA), Government Departments, and private business. Generalisation of Geographic Information: Cartographic Modelling and Applications provides detailed review
The relationships between perfectionism, pathological worry and generalised anxiety disorder
Handley, Alicia K; Egan, Sarah J.; Kane, Robert T.; Rees, Clare S
2014-01-01
Background The relationships between perfectionism, pathological worry and generalised anxiety disorder (GAD) were investigated in a clinical sample presenting for treatment of perfectionism. Method This study explored the utility of perfectionism in predicting pathological worry in a sample of individuals with elevated perfectionism and GAD (n = 36). Following this, the study examined whether perfectionism could predict a principal GAD diagnosis in the full sample (n = 42). Results Scores on...
Generalised Modal Analysis with the Pad\\'e-Laplace transform
Tannous, C
2003-01-01
We present the G-MAPLE (Generalised Modal Analysis from the Poles of the Laplace Expansion) software that allows decomposing data depending on a single parameter (such as time series data) into a set of exponential functions having complex amplitudes and arguments. The novelty is that G-MAPLE determines the unknown number of exponentials in the data along with the corresponding complex amplitudes and arguments.
Generalised pole-placement control of steam turbine speed
Fernandez-del-Busto, R. [ITESM, Cuernavaca (Mexico). Div. de Ingenieria y Ciencias; Munoz, J. [ITESM, Xochimilco (Mexico). Div. de Ingenieria y Ciencias
1996-12-31
An application of a pole-placement self-tuning predictive control algorithm is developed to regulate speed of a power plant steam turbine model. Two types of system representation (CARMA and CARIMA) are used to test the control algorithm. Simulation results show that when using a CARMA model better results are produced. Two further comparisons are made when using a PI controller and a generalised predictive controller. (author)
The stability of vacuum solutions in generalised gravity
Madsen, M.S. (Sussex Univ., Brighton (UK). Astronomy Centre); Low, R.J. (Coventry (Lanchester) Polytechnic (UK). Dept. of Mathematics)
1990-05-10
The stability of the Ricci-flat solutions of a large class of generalised gravity theories is examined. It is shown by use of complementary methods that all such solutions are stable in a given theory if that theory admits a truncation to a quadratic theory in which the solution is stable. In particular, this means that the exterior Schwarzschild solution is stable in any gravity theory constructed purely from the Ricci scalar, provided that it exists in that theory. (orig.).
Generalised Chou-Yang model and recent results
Fazal-e-Aleem [International Centre for Theoretical Physics, Trieste (Italy); Rashid, H. [Punjab Univ., Lahore (Pakistan). Centre for High Energy Physics
1996-12-31
It is shown that most recent results of E710 and UA4/2 collaboration for the total cross section and {rho} together with earlier measurements give good agreement with measurements for the differential cross section at 546 and 1800 GeV within the framework of Generalised Chou-Yang model. These results are also compared with the predictions of other models. (author) 16 refs.
Generalised k-Steiner Tree Problems in Normed Planes
2011-01-01
The 1-Steiner tree problem, the problem of constructing a Steiner minimum tree containing at most one Steiner point, has been solved in the Euclidean plane by Georgakopoulos and Papadimitriou using plane subdivisions called oriented Dirichlet cell partitions. Their algorithm produces an optimal solution within $O(n^2)$ time. In this paper we generalise their approach in order to solve the $k$-Steiner tree problem, in which the Steiner minimum tree may contain up to $k$ Steiner points for a gi...
Generalised Planar Black Holes and the Holography of Hydrodynamic Shear
McInnes, Brett
2013-01-01
AdS black holes with planar event horizon topology play a central role in AdS/CFT holography, and particularly in its applications. Generalisations of the known planar black holes can be found by considering the Plebanski--Demianski metrics, a very general family of exactly specified solutions of the Einstein equations. These generalised planar black holes may be useful in applications. We give a concrete example of this in the context of the holographic description of the Quark-Gluon Plasma (QGP). We argue that our generalised planar black holes allow us to construct a model of the internal shearing motion generated when the QGP is produced in peripheral heavy-ion collisions. When embedded in string theory, the bulk physics is in fact unstable. We find however that this instability may develop too slowly to affect the evolution of the plasma, except possibly for high values of the quark chemical potential, such as will be studied in experimental scans of the quark matter phase diagram.
Generalised pollination systems for three invasive milkweeds in Australia.
Ward, M; Johnson, S D
2013-05-01
Because most plants require pollinator visits for seed production, the ability of an introduced plant species to establish pollinator relationships in a new ecosystem may have a central role in determining its success or failure as an invader. We investigated the pollination ecology of three milkweed species - Asclepias curassavica, Gomphocarpus fruticosus and G. physocarpus - in their invaded range in southeast Queensland, Australia. The complex floral morphology of milkweeds has often been interpreted as a general trend towards specialised pollination requirements. Based on this interpretation, invasion by milkweeds contradicts the expectation than plant species with specialised pollination systems are less likely to become invasive that those with more generalised pollination requirements. However, observations of flower visitors in natural populations of the three study species revealed that their pollination systems are essentially specialised at the taxonomic level of the order, but generalised at the species level. Specifically, pollinators of the two Gomphocarpus species included various species of Hymenoptera (particularly vespid wasps), while pollinators of A. curassavica were primarily Lepidoptera (particularly nymphalid butterflies). Pollinators of all three species are rewarded with copious amounts of highly concentrated nectar. It is likely that successful invasion by these three milkweed species is attributable, at least in part, to their generalised pollinator requirements. The results of this study are discussed in terms of how data from the native range may be useful in predicting pollination success of species in a new environment.
Heterogeneous locational optimisation using a generalised Voronoi partition
Guruprasad, K. R.; Ghose, Debasish
2013-06-01
In this paper a generalisation of the Voronoi partition is used for locational optimisation of facilities having different service capabilities and limited range or reach. The facilities can be stationary, such as base stations in a cellular network, hospitals, schools, etc., or mobile units, such as multiple unmanned aerial vehicles, automated guided vehicles, etc., carrying sensors, or mobile units carrying relief personnel and materials. An objective function for optimal deployment of the facilities is formulated, and its critical points are determined. The locally optimal deployment is shown to be a generalised centroidal Voronoi configuration in which the facilities are located at the centroids of the corresponding generalised Voronoi cells. The problem is formulated for more general mobile facilities, and formal results on the stability, convergence and spatial distribution of the proposed control laws responsible for the motion of the agents carrying facilities, under some constraints on the agents' speed and limit on the sensor range, are provided. The theoretical results are supported with illustrative simulation results.
Skew category algebras associated with partially defined dynamical systems
Lundström, Patrik; Öinert, Per Johan
2012-01-01
We introduce partially defined dynamical systems defined on a topological space. To each such system we associate a functor s from a category G to Topop and show that it defines what we call a skew category algebra A ⋊σ G. We study the connection between topological freeness of s and, on the one...
An Identity with Skew Derivations on Lie Ideals
Wang Zheng-ping; Rehman Ur Nadeem; Huang Shu-liang
2016-01-01
Let R be a 2-torsion free prime ring and L a noncommutative Lie ideal of R. Suppose that (d,σ) is a skew derivation of R such that xsd(x)xt = 0 for all x∈L, where s, t are fixed non-negative integers. Then d=0.
Modelling psychiatric measures using Skew-Normal distributions
Counsell, N.; Cortina-Borja, M.; Lehtonen, A.; Stein, A.
2011-01-01
Data from psychiatric research frequently exhibit departures from Normality. Methods which utilise the data optimally to model the distribution directly are available. We highlight the issue of modelling skewness, resulting from screening instruments where the majority of respondents are healthy individuals and few participants have a value reflecting particular disorders. PMID:21036551
Conglomerate investment, skewness, and the CEO long shot bias
Schneider, C.A.R.; Spalt, Oliver
2016-01-01
Do behavioral biases of executives matter for corporate investment decisions? Using segment-level capital allocation in multi-segment firms ("conglomerates") as a laboratory, we show that capital expenditure is increasing in the expected skewness of segment returns. Conglomerates invest more in high
Asymmetric skew Bessel processes and their applications to finance
Decamps, M.; Goovaerts, M.J.; Schoutens, W.
2006-01-01
In this paper, we extend the Harrison and Shepp's construction of the skew Brownian motion (1981) and we obtain a diffusion similar to the two-dimensional Bessel process with speed and scale densities discontinuous at one point. Natural generalizations to multi-dimensional and fractional order
Conglomerate investment, skewness, and the CEO long shot bias
Schneider, C.A.R.; Spalt, Oliver
2016-01-01
Do behavioral biases of executives matter for corporate investment decisions? Using segment-level capital allocation in multi-segment firms ("conglomerates") as a laboratory, we show that capital expenditure is increasing in the expected skewness of segment returns. Conglomerates invest more in
Large deflection analysis of skew plates under uniformly distributed ...
user
load-deflection plane to show the effect of skew angle, aspect ratio and boundary condition. ... by edge 1, 2, 3 and 4 on the plate boundaries in Figures 1(a)-1(d). ... one-dimensional coordinate functions along normalized coordinate are shown ...
Uncertainty relations based on skew information with quantum memory
Ma, ZhiHao; Chen, ZhiHua; Fei, Shao-Ming
2017-01-01
We present a new uncertainty relation by defining a measure of uncertainty based on skew information. For bipartite systems, we establish uncertainty relations with the existence of a quantum memory. A general relation between quantum correlations and tight bounds of uncertainty has been presented.
Parameterizing unconditional skewness in models for financial time series
He, Changli; Silvennoinen, Annastiina; Teräsvirta, Timo
In this paper we consider the third-moment structure of a class of time series models. It is often argued that the marginal distribution of financial time series such as returns is skewed. Therefore it is of importance to know what properties a model should possess if it is to accommodate...
Generating monthly rainfall amount using multivariate skew-t copula
Radi, Noor Fadhilah Ahmad; Zakaria, Roslinazairimah; Zanariah Satari, Siti
2017-09-01
This study aims to generate rainfall data in cases where the data is not available or not enough for a certain area of study. In general, the rainfall data is rightly skewed, so the multivariate skew-t copula is used as it able to model rainfall amount and capture the spatial dependence in the data. To illustrate the methodology, three rainfall stations in Kelantan are used. Firstly, the observed data is transformed to uniform unit. The Spearman’s correlation coefficient is calculated between the three stations. It is found that the correlations between the stations are significance at α = 0.05. The next step involved generating the synthetic rainfall data using the multivariate skew-t copula. The data is then transformed to uniform unit and the correlation coefficient is calculated for the generated data. Finally, the correlation coefficient of the observed and the generated data are compared. The Kolmogorov-Smirnov goodness of fit test is used to assess the fit between theoretical and empirical copula and supported by graphical representation. The results show that there is no significant difference between empirical and theoretical copula at 5% significance level. Thus, the multivariate skew-t copula is suitable to generate synthetic rainfall data that can mimic the observed rainfall data. It can also be used to present different rainfall scenarios by changing the value of the parameters in the model.
Jiang, Zhaolin; Shen, Nuo; Zhou, Jianwei
2013-01-01
We first give the style spectral decomposition of a special skew circulant matrix C and then get the style decomposition of arbitrary skew circulant matrix by making use of the Kronecker products between the elements of first row in skew circulant and the special skew circulant C. Besides that, we obtain the singular value of skew circulant matrix as well. Finally, we deal with the optimal backward perturbation analysis for the linear system with skew circulant coefficient matrix on the base of its style spectral decomposition. PMID:24369488
Root waving and skewing - unexpectedly in micro-g
Roux Stanley J
2012-12-01
Full Text Available Abstract Gravity has major effects on both the form and overall length of root growth. Numerous papers have documented these effects (over 300 publications in the last 5 years, the most well-studied being gravitropism, which is a growth re-orientation directed by gravity toward the earth’s center. Less studied effects of gravity are undulations due to the regular periodic change in the direction root tips grow, called waving, and the slanted angle of growth roots exhibit when they are growing along a nearly-vertical surface, called skewing. Although diverse studies have led to the conclusion that a gravity stimulus is needed for plant roots to show waving and skewing, the novel results just published by Paul et al. (2012 reveal that this conclusion is not correct. In studies carried out in microgravity on the International Space Station, the authors used a new imaging system to collect digital photographs of plants every six hours during 15 days of spaceflight. The imaging system allowed them to observe how roots grew when their orientation was directed not by gravity but by overhead LED lights, which roots grew away from because they are negatively phototropic. Surprisingly, the authors observed both skewing and waving in spaceflight plants, thus demonstrating that both growth phenomena were gravity independent. Touch responses and differential auxin transport would be common features of root waving and skewing at 1-g and micro-g, and the novel results of Paul et al. will focus the attention of cell and molecular biologists more on these features as they try to decipher the signaling pathways that regulate root skewing and waving.
Present-day zonal wind influences projected Indian Ocean Dipole skewness
Ng, Benjamin; Cai, Wenju
2016-11-01
A prominent feature of the Indian Ocean Dipole (IOD) is its positive skewness, where positive phases tend to be stronger in amplitude than the negative phase. Positive IOD events are associated with devastating floods over parts of East Africa and India, while Australia and Indonesia experience dry conditions. Under greenhouse warming, climate models project a weakening of the positive IOD skewness, but their simulation of present-day skewness is too weak. Here we show that this bias and the projected skewness change are related to the simulation of the climatological zonal wind in the central equatorial Indian Ocean. In particular, models with overly weak present-day westerlies, which is a common model bias, generate overly weak present-day skewness and a smaller projected reduction in skewness. Improving the ability of models in simulating stronger westerly winds may lead to stronger present-day simulated skewness and a larger skewness reduction in a warmer climate.
Joint IQ Skew and Chromatic Dispersion Estimation for Coherent Optical Communication Receivers
Medeiros Diniz, Júlio César; Porto da Silva, Edson; Piels, Molly
2016-01-01
A low-complexity scanning method for joint estimation of receiver IQ skew and chromatic dispersion is proposed. This method shows less than 1 ps skew error for a 1200-km 32-GBd DP-16QAM optical transmission experiment.......A low-complexity scanning method for joint estimation of receiver IQ skew and chromatic dispersion is proposed. This method shows less than 1 ps skew error for a 1200-km 32-GBd DP-16QAM optical transmission experiment....
Non-abelian T-duality, generalised geometry and holography
Macpherson, Niall T
2013-01-01
Recent progress which relates non-abelian T-duality of $\\mathcal{N}=1$ SuGra solutions to the powerful techniques of Generalised geometry is reviewed. It is shown that SU(3) structure solutions are mapped to SU(2) structures and the transformation rule of the corresponding pure spinors is presented. This constitutes an important step on the road towards the utility of the duality within holography, showing for example, how smeared sources must transform and so how to add flavour to the T-duals.
A generalised Rayleigh-Taylor condition for the Muskat problem
Escher, Joachim; Matioc, Bogdan-Vasile
2010-01-01
In this paper we consider the evolution of two fluid phases in a porous medium. The fluids are separated from each other and also the wetting phase from air by interfaces which evolve in time. We reduce the problem to an abstract evolution equation. A generalised Rayleigh-Taylor condition characterizes the parabolicity regime of the problem and allows us to establish a general well-posedness result and to study stability properties of flat steady-states. When considering surface tension effects at the interface between the fluids and if the more dense fluid lies above, we find bifurcating finger-shaped equilibria which are all unstable.
Hamiltonians with Riesz Bases of Generalised Eigenvectors and Riccati Equations
Wyss, Christian
2010-01-01
An algebraic Riccati equation for linear operators is studied, which arises in systems theory. For the case that all involved operators are unbounded, the existence of infinitely many selfadjoint solutions is shown. To this end, invariant graph subspaces of the associated Hamiltonian operator matrix are constructed by means of a Riesz basis with parentheses of generalised eigenvectors and two indefinite inner products. Under additional assumptions, the existence and a representation of all bounded solutions is obtained. The theory is applied to Riccati equations of differential operators.
Categories vs. groupoids via generalised Mal'tsev properties
2014-01-01
We study the difference between internal categories and internal groupoids in terms of generalised Mal'tsev properties---the weak Mal'tsev property on the one hand, and $n$-permutability on the other. In the first part of the article we give conditions on internal categorical structures which detect whether the surrounding category is naturally Mal'tsev, Mal'tsev or weakly Mal'tsev. We show that these do not depend on the existence of binary products. In the second part we focus on varieties ...
Generalised Hermite-Gaussian beams and mode transformations
Wang, Yi; Zhang, Yanfeng; Chen, Hui; Yu, Siyuan
2016-01-01
Generalised Hermite-Gaussian modes (gHG modes), an extended notion of Hermite-Gaussian modes (HG modes), are formed by the summation of normal HG modes with a characteristic function $\\alpha$, which can be used to unite conventional HG modes and Laguerre-Gaussian modes (LG modes). An infinite number of normalised orthogonal modes can thus be obtained by modulation of the function $\\alpha$. The gHG mode notion provides a useful tool in analysis of the deformation and transformation phenomena occurring in propagation of HG and LG modes with astigmatic perturbation.
Generalised Boundary for Higher Derivative Theories of Gravity
Teimouri, Ali; Edholm, James; Mazumdar, Anupam
2016-01-01
In this paper we wish to find the corresponding Gibbons-Hawking-York term for the most general quadratic in curvature gravity by using Coframe slicing within the Arnowitt-Deser-Misner (ADM) decomposition of spacetime in four dimensions. In order to make sure that the higher derivative gravity is ghost and tachyon free at a perturbative level, one requires infinite covariant derivatives, which yields a generalised covariant infinite derivative theory of gravity. We will be exploring the boundary term for such a covariant infinite derivative theory of gravity.
Electric monopoles in generalised B\\wedge F theories
Temple-Raston, M
1996-01-01
A tensor product generalisation of B\\wedge F theories is proposed to give a Bogomol'nyi structure. Non-singular, stable, finite-energy particle-like solutions to the Bogomol'nyi equations are studied. Unlike Yang-Mills(-Higgs) theory, the Bogomol'nyi structure does not appear as a perfect square in the Lagrangian. Consequently, the Bogomol'nyi energy can be obtained in more than one way. The added flexibility permits electric monopole solutions to the field equations.
Generalised boundary terms for higher derivative theories of gravity
Teimouri, Ali; Talaganis, Spyridon; Edholm, James; Mazumdar, Anupam
2016-08-01
In this paper we wish to find the corresponding Gibbons-Hawking-York term for the most general quadratic in curvature gravity by using Coframe slicing within the Arnowitt-Deser-Misner (ADM) decomposition of spacetime in four dimensions. In order to make sure that the higher derivative gravity is ghost and tachyon free at a perturbative level, one requires infinite covariant derivatives, which yields a generalised covariant infinite derivative theory of gravity. We will be exploring the boundary term for such a covariant infinite derivative theory of gravity.
The use of Generalised Functions and Distributions in General Relativity
Steinbauer, R; Steinbauer, Roland; Vickers, James A.
2006-01-01
In this paper we review the extent to which one can use classical distribution theory in describing solutions of Einstein's equations. We show that there are a number of physically interesting cases which cannot be treated using distribution theory but require a more general concept. We describe a mathematical theory of nonlinear generalised functions based on Colombeau algebras and show how this may be applied in general relativity. We end by discussing the concept of singularity in general relativity and show that certain solutions with weak singularities may be regarded as distributional solutions of Einstein's equations.
Generalised boundary terms for higher derivative theories of gravity
Teimouri, Ali; Talaganis, Spyridon; Edholm, James [Consortium for Fundamental Physics, Lancaster University,North West Drive, Lancaster, LA1 4YB (United Kingdom); Mazumdar, Anupam [Consortium for Fundamental Physics, Lancaster University,North West Drive, Lancaster, LA1 4YB (United Kingdom); Kapteyn Astronomical Institute, University of Groningen,9700 AV Groningen (Netherlands)
2016-08-24
In this paper we wish to find the corresponding Gibbons-Hawking-York term for the most general quadratic in curvature gravity by using Coframe slicing within the Arnowitt-Deser-Misner (ADM) decomposition of spacetime in four dimensions. In order to make sure that the higher derivative gravity is ghost and tachyon free at a perturbative level, one requires infinite covariant derivatives, which yields a generalised covariant infinite derivative theory of gravity. We will be exploring the boundary term for such a covariant infinite derivative theory of gravity.
Baker-Akhiezer functions and generalised Macdonald-Mehta integrals
Feigin, M. V.; Hallnäs, M. A.; Veselov, A. P.
2013-05-01
For the rational Baker-Akhiezer functions associated with special arrangements of hyperplanes with multiplicities we establish an integral identity, which may be viewed as a generalisation of the self-duality property of the usual Gaussian function with respect to the Fourier transformation. We show that the value of properly normalised Baker-Akhiezer function at the origin can be given by an integral of Macdonald-Mehta type and explicitly compute these integrals for all known Baker-Akhiezer arrangements. We use the Dotsenko-Fateev integrals to extend this calculation to all deformed root systems, related to the non-exceptional basic classical Lie superalgebras.
Spacetimes with vector distortion: Inflation from generalised Weyl geometry
Beltrán Jiménez, Jose, E-mail: jose.beltran@cpt.univ-mrs.fr [CPT, Aix Marseille Université, UMR 7332, 13288 Marseille (France); Koivisto, Tomi S., E-mail: tomi.koivisto@nordita.org [Nordita, KTH Royal Institute of Technology and Stockholm University, Roslagstullsbacken 23, 10691 Stockholm (Sweden)
2016-05-10
Spacetime with general linear vector distortion is introduced. Thus, the torsion and the nonmetricity of the affine connection are assumed to be proportional to a vector field (and not its derivatives). The resulting two-parameter family of non-Riemannian geometries generalises the conformal Weyl geometry and some other interesting special cases. Taking into account the leading nonlinear correction to the Einstein–Hilbert action results uniquely in the one-parameter extension of the Starobinsky inflation known as the alpha-attractor. The most general quadratic curvature action introduces, in addition to the canonical vector kinetic term, novel ghost-free vector-tensor interactions.
Spacetimes with vector distortion: Inflation from generalised Weyl geometry
Jose Beltrán Jiménez
2016-05-01
Full Text Available Spacetime with general linear vector distortion is introduced. Thus, the torsion and the nonmetricity of the affine connection are assumed to be proportional to a vector field (and not its derivatives. The resulting two-parameter family of non-Riemannian geometries generalises the conformal Weyl geometry and some other interesting special cases. Taking into account the leading nonlinear correction to the Einstein–Hilbert action results uniquely in the one-parameter extension of the Starobinsky inflation known as the alpha-attractor. The most general quadratic curvature action introduces, in addition to the canonical vector kinetic term, novel ghost-free vector-tensor interactions.
Technological Inefficiency and the Skewness of the Error Component in Stochastic Frontier Analysis
M.A. Carree (Martin)
2002-01-01
textabstractThis paper concentrates on negatively skewed one-sided distributions as an explanation of the occurence of positive (negative) skewness in the case of stochastic production (cost) frontier analysis. It takes as example the binomial distribution that can have negative or positive skew and
Dimension theoretical study on skew product maps with coupled-expanding property
Jinhyon Kim
2014-03-01
Full Text Available We discuss on some families of skew product maps on a square. For a kind of skew product maps with coupled-expanding property, we estimate Hausdorff dimension of its attractor. And we prove that there exists an ergodic measure with full Hausdorff dimension for this kind of skew product maps.
Regularized multivariate regression models with skew-t error distributions
Chen, Lianfu
2014-06-01
We consider regularization of the parameters in multivariate linear regression models with the errors having a multivariate skew-t distribution. An iterative penalized likelihood procedure is proposed for constructing sparse estimators of both the regression coefficient and inverse scale matrices simultaneously. The sparsity is introduced through penalizing the negative log-likelihood by adding L1-penalties on the entries of the two matrices. Taking advantage of the hierarchical representation of skew-t distributions, and using the expectation conditional maximization (ECM) algorithm, we reduce the problem to penalized normal likelihood and develop a procedure to minimize the ensuing objective function. Using a simulation study the performance of the method is assessed, and the methodology is illustrated using a real data set with a 24-dimensional response vector. © 2014 Elsevier B.V.
Quantifying Correlations via the Wigner-Yanase-Dyson Skew Information
Fan, Yajing; Cao, Huaixin
2016-09-01
In this paper, based on a discussion about the Wigner-Yanase-Dyson (WYD) skew information, the measure F a, α ( ρ a b ) for correlations in terms of the WYD skew information is introduced and discussed. The following conclusions are obtained. For a classical-quantum state ρ a b , F a, α ( ρ a b )=0 if and only if ρ a b is a product state; F a, α ( ρ a b ) is locally unitary invariant and convex on the set of states with the fixed marginal ρ a ; F a, α ( ρ a b ) decreases under local random unitary operation on H b ; For a quantum-classical state ρ a b , F a, α ( ρ a b ) decreases under local operation on H b ; Lastly, F a, α ( ρ a b ) is computed for the pure states and the Bell-diagonal states, respectively.
Right Skewed Distribution of Activity Times in PERT
N.Ravi Shankar,
2011-04-01
Full Text Available A usual supposition in project management is that the distribution for most activities in a project network is right skewed. The prime objective of this paper is to find new path float in Program Evaluation and Review Technique (PERT for right skewed distribution of activity times in a project network. The new path float concept will bring useful planning information to the decision managers and the planners in the project construction. Our new path float in PERT are compared with normal, lognormal approximations with two parameters and also with beta approximations with three parameters. The comparison reveals that beta approximations with three parameters performs better than normal and lognormal approximations suggested.
Universal relation between skewness and kurtosis in complex dynamics.
Cristelli, Matthieu; Zaccaria, Andrea; Pietronero, Luciano
2012-06-01
We identify an important correlation between skewness and kurtosis for a broad class of complex dynamic systems and present a specific analysis of earthquake and financial time series. Two regimes of non-Gaussianity can be identified: a parabolic one, which is common in various fields of physics, and a power law one, with exponent 4/3, which at the moment appears to be specific of earthquakes and financial markets. For this property we propose a model and an interpretation in terms of very rare events dominating the statistics independently on the nature of the events considered. The predicted scaling relation between skewness and kurtosis matches very well the experimental pattern of the second regime. Regarding price fluctuations, this situation characterizes a universal stylized fact.
Neural Network Approach to Railway Stand Lateral SKEW Control
Peter Mark Benes
2014-02-01
Full Text Available The paper presents a study of an adaptive approach to lateral skew co ntrol for an experimental railway stand. The preliminary experiments with the real ex perimental railway stand and simulations with its 3-D mechanical model, indicates difficulties of model-based control of the device. Thus, use of neural networks for identification and c ontrol of lateral skew shall be investigated. This paper focuses on real-data based modelling of the railway stand by various neural network models, i.e; linear neural unit and quadratic neur al unit architectures. Furthermore, training methods of these neural architecture s as such, real-time-recurrent- learning and a variation of back-propagation-through-time are exam ined, accompanied by a discussion of the produced experimental results
Estimating incremental costs with skew: a cautionary note.
Polgreen, Linnea A; Brooks, John M
2012-09-01
Cost data in healthcare are often skewed across patients. Thus, researchers have used either a log transformation of the dependent variable or generalized linear models with log links. However, frequently these non-linear approaches produce non-linear incremental effects: the incremental effects differ at different levels of the covariates, and this can cause dramatic effects on predicted cost. The aim of this study was to demonstrate that when modelling skewed data, log link functions or log transformations are not necessary and have unintended effects. We simulated cost data using a linear model with a 'treatment', a covariate and a specified number of observations with excessive cost (skewed data). We also used actual data from a pain-relief intervention among hip-replacement patients. We then estimated cost models using various functional approaches suggested to handle skew and calculated the incremental cost of treatment at various levels of the covariate(s). All of these methods provide unbiased estimates of the incremental effect of treatment on costs at the mean level of the covariate. However, in some log-based models the implied incremental treatment cost doubled between extreme low and high values of the covariate in a manner inconsistent with the underlying linear model. Although specification checks are always needed, the potential for misleading incremental estimates resulting from log-based specifications is often ignored. In this era of cost containment and comparisons of treatment effectiveness it is vital that researchers and policymakers understand the limitation of the inferences that can be made using log-based models for patients whose characteristics differ from the sample mean.
MEASURING LOCAL GRADIENT AND SKEW QUADRUPOLE ERRORS IN RHIC IRS.
CARDONA,J.; PEGGS,S.; PILAT,R.; PTITSYN,V.
2004-07-05
The measurement of local linear errors at RHIC interaction regions using an ''action and phase'' analysis of difference orbits has already been presented. This paper evaluates the accuracy of this technique using difference orbits that were taken when known gradient errors and skew quadrupole errors were intentionally introduced. It also presents action and phase analysis of simulated orbits when controlled errors are intentionally placed in a RHIC simulation model.
Incorporating Skew into RMS Surface Roughness Probability Distribution
Stahl, Mark T.; Stahl, H. Philip.
2013-01-01
The standard treatment of RMS surface roughness data is the application of a Gaussian probability distribution. This handling of surface roughness ignores the skew present in the surface and overestimates the most probable RMS of the surface, the mode. Using experimental data we confirm the Gaussian distribution overestimates the mode and application of an asymmetric distribution provides a better fit. Implementing the proposed asymmetric distribution into the optical manufacturing process would reduce the polishing time required to meet surface roughness specifications.
Conformal string operators and evolution of skewed parton distributions
Kivel, N A
1999-01-01
We have investigated skewed parton distributions in coordinate space. We found that their evolution can be described in a simple manner in terms of non-local, conformal operators introduced by Balitsky and Braun. The resulting formula is given by a Neumann series expansion. Its structure resembles, for all values of the asymmetry parameter, the well-known solution of the ERBL equation in the momentum space. Performing Fourier transformation we have reproduced known results for evolution of momentum-space distributions.
The skew product Markov chain%Markov－双链
张王月; 张金洪; 邹健
2001-01-01
就随机环境下的 Markov－链，介绍了 Markov－双链的构造，并证明了以已给 P(θ )为转移概率的 Markov－双链的存在性 .当环境空间和状态空间均可数时，希望通过对 Markov－双链的研究，进而实现对随机环境下的 Markov－链的研究 .%The process of the construction of the skew product Markov Chain on the basic of the Markov Chain in random environments is introduced and the existence of the skew product Markov Chain is proven, taking the given P(θ ) as the transition probability. The Markov Chain in random environments by studying the skew product Markov chain , can be studied when the environment space and the state space are countable.
Tide and skew surge independence: New insights for flood risk
Williams, Joanne; Horsburgh, Kevin J.; Williams, Jane A.; Proctor, Robert N. F.
2016-06-01
Storm surges are a significant hazard to coastal communities around the world, putting lives at risk and costing billions of dollars in damage. Understanding how storm surges and high tides interact is crucial for estimating extreme water levels so that we can protect coastal communities. We demonstrate that in a tidal regime the best measure of a storm surge is the skew surge, the difference between the observed and predicted high water within a tidal cycle. Based on tide gauge records spanning decades from the UK, U.S., Netherlands, and Ireland we show that the magnitude of high water exerts no influence on the size of the most extreme skew surges. This is the first systematic proof that any storm surge can occur on any tide, which is essential for understanding worst-case scenarios. The lack of surge generation dependency on water depth emphasizes the dominant natural variability of weather systems in an observation-based analysis. Weak seasonal relationships between skew surges and high waters were identified at a minority of locations where long-period changes to the tidal cycle interact with the storm season. Our results allow advances to be made in methods for estimating the joint probabilities of storm surges and tides.
Central limit theorem behavior in the skew tent map
Mackey, Michael C. [Departments of Physiology, Physics and Mathematics and Centre for Nonlinear Dynamics, McGill University, 3655 Promenade Sir William Osler, Montreal, Que., Canada H3G 1Y6 (Canada)], E-mail: michael.mackey@mcgill.ca; Tyran-Kaminska, Marta [Institute of Mathematics, University of Silesia, ul. Bankowa 14, 40-007 Katowice (Poland)], E-mail: mtyran@us.edu.pl
2008-11-15
In this paper we study and establish central limit theorem behavior in the skew (generalized) tent map transformation T: Y {yields}Y originally considered by Billings and Bollt [Billings L, Bollt EM. Probability density functions of some skew tent maps. Chaos, Solitons and Fractals 2001; 12: 365-376] and Ito et al. [Ito S, Tanaka S, Nakada H. On unimodal linear transformations and chaos. II. Tokyo J Math 1979; 2: 241-59]. When the measure {nu} is invariant under T, the transfer operator P{sub T}:L{sup 1}({nu}){yields}L{sup 1}({nu}) governing the evolution of densities f under the action of the skew tent map, as well as the unique stationary density, are given explicitly for specific transformation parameters. Then, using this development, we solve the Poisson equation f=P{sub T}f+{phi} for two specific integrable observables {phi} and explicitly calculate the variance {sigma}({phi}){sup 2}={integral}{sub Y}{phi}{sup 2}(y){nu}(dy)
Kurtosis, skewness, and non-Gaussian cosmological density perturbations
Luo, Xiaochun; Schramm, David N.
1993-01-01
Cosmological topological defects as well as some nonstandard inflation models can give rise to non-Gaussian density perturbations. Skewness and kurtosis are the third and fourth moments that measure the deviation of a distribution from a Gaussian. Measurement of these moments for the cosmological density field and for the microwave background temperature anisotropy can provide a test of the Gaussian nature of the primordial fluctuation spectrum. In the case of the density field, the importance of measuring the kurtosis is stressed since it will be preserved through the weakly nonlinear gravitational evolution epoch. Current constraints on skewness and kurtosis of primeval perturbations are obtained from the observed density contrast on small scales and from recent COBE observations of temperature anisotropies on large scales. It is also shown how, in principle, future microwave anisotropy experiments might be able to reveal the initial skewness and kurtosis. It is shown that present data argue that if the initial spectrum is adiabatic, then it is probably Gaussian, but non-Gaussian isocurvature fluctuations are still allowed, and these are what topological defects provide.
Rule Generalisation in Intrusion Detection Systems using Snort
Aickelin, Uwe; Hesketh-Roberts, Thomas
2008-01-01
Intrusion Detection Systems (ids)provide an important layer of security for computer systems and networks, and are becoming more and more necessary as reliance on Internet services increases and systems with sensitive data are more commonly open to Internet access. An ids responsibility is to detect suspicious or unacceptable system and network activity and to alert a systems administrator to this activity. The majority of ids use a set of signatures that define what suspicious traffic is, and Snort is one popular and actively developing open-source ids that uses such a set of signatures known as Snort rules. Our aim is to identify a way in which Snort could be developed further by generalising rules to identify novel attacks. In particular, we attempted to relax and vary the conditions and parameters of current Snort rules, using a similar approach to classic rule learning operators such as generalisation and specialisation. We demonstrate the effectiveness of our approach through experiments with standard d...
An extensive investigation of the Generalised Dark Matter model
Kopp, Michael; Thomas, Dan B
2016-01-01
The Cold Dark Matter (CDM) model, wherein the dark matter is treated as a pressureless perfect fluid, provides a good fit to galactic and cosmological data. With the advent of precision cosmology, it should be asked whether this simplest model needs to be extended, and whether doing so could improve our understanding of the properties of dark matter. One established parameterisation for generalising the CDM fluid is the Generalised Dark Matter (GDM) model, in which dark matter is an imperfect fluid with pressure and shear viscosity that fulfill certain closure equations. We investigate these closure equations and the three new parametric functions they contain: the background equation of state w, the speed of sound c_s^2 and the viscosity c_{vis}^2. Taking these functions to be constant parameters, we analyse an exact solution of the perturbed Einstein equations in a GDM-dominated universe and discuss the main effects of the three parameters on the Cosmic Microwave Background (CMB). Our analysis suggests that...
Generalising Ward’s Method for Use with Manhattan Distances
Strauss, Trudie; von Maltitz, Michael Johan
2017-01-01
The claim that Ward’s linkage algorithm in hierarchical clustering is limited to use with Euclidean distances is investigated. In this paper, Ward’s clustering algorithm is generalised to use with l1 norm or Manhattan distances. We argue that the generalisation of Ward’s linkage method to incorporate Manhattan distances is theoretically sound and provide an example of where this method outperforms the method using Euclidean distances. As an application, we perform statistical analyses on languages using methods normally applied to biology and genetic classification. We aim to quantify differences in character traits between languages and use a statistical language signature based on relative bi-gram (sequence of two letters) frequencies to calculate a distance matrix between 32 Indo-European languages. We then use Ward’s method of hierarchical clustering to classify the languages, using the Euclidean distance and the Manhattan distance. Results obtained from using the different distance metrics are compared to show that the Ward’s algorithm characteristic of minimising intra-cluster variation and maximising inter-cluster variation is not violated when using the Manhattan metric. PMID:28085891
The affective impact of financial skewness on neural activity and choice.
Charlene C Wu
Full Text Available Few finance theories consider the influence of "skewness" (or large and asymmetric but unlikely outcomes on financial choice. We investigated the impact of skewed gambles on subjects' neural activity, self-reported affective responses, and subsequent preferences using functional magnetic resonance imaging (FMRI. Neurally, skewed gambles elicited more anterior insula activation than symmetric gambles equated for expected value and variance, and positively skewed gambles also specifically elicited more nucleus accumbens (NAcc activation than negatively skewed gambles. Affectively, positively skewed gambles elicited more positive arousal and negatively skewed gambles elicited more negative arousal than symmetric gambles equated for expected value and variance. Subjects also preferred positively skewed gambles more, but negatively skewed gambles less than symmetric gambles of equal expected value. Individual differences in both NAcc activity and positive arousal predicted preferences for positively skewed gambles. These findings support an anticipatory affect account in which statistical properties of gambles--including skewness--can influence neural activity, affective responses, and ultimately, choice.
Generalising tractable VCSPs defined by symmetric tournament pair multimorphisms
Kolmogorov, Vladimir
2010-01-01
We study optimisation problems that can be formulated as valued constraint satisfaction problems (VCSP). A problem from VCSP is characterised by a \\emph{constraint language}, a fixed set of cost functions taking finite and infinite costs over a finite domain. An instance of the problem is specified by a sum of cost functions from the language and the goal is to minimise the sum. We are interested in \\emph{tractable} constraint languages; that is, languages that give rise to VCSP instances solvable in polynomial time. Cohen et al. (AIJ'06) have shown that constraint languages that admit the MJN multimorphism are tractable. Moreover, using a minimisation algorithm for submodular functions, Cohen et al. (TCS'08) have shown that constraint languages that admit an STP (symmetric tournament pair) multimorphism are tractable. We generalise these results by showing that languages admitting the MJN multimorphism on a subdomain and an STP multimorphisms on the complement of the subdomain are tractable. The algorithm is...
Generalised integrable $\\lambda$- and $\\eta$-deformations and their relation
Sfetsos, Konstantinos; Thompson, Daniel C
2015-01-01
We construct two-parameter families of integrable $\\lambda$-deformations of two-dimensional field theories. These interpolate between a CFT (a WZW/gauged WZW model) and the non-Abelian T-dual of a principal chiral model on a group/symmetric coset space. In examples based on the $SU(2)$ WZW model and the $SU(2)/U(1)$ exact coset CFT, we show that these deformations are related to bi-Yang-Baxter generalisations of $\\eta$-deformations via Poisson-Lie T-duality and analytic continuation. We illustrate the quantum behaviour of our models under RG flow. As a byproduct we demonstrate that the bi-Yang-Baxter $\\sigma$-model for a general group is one-loop renormalisable.
The constrained KP hierarchy and the generalised Miura transformation
Mas, J; Mas, Javier; Ramos, Eduardo
1995-01-01
Recently much attention has been paid to the restriction of KP to the submanifold of operators which can be represented as a ratio of two purely differential operators L=AB^{-1}. Whereas most of the aspects concerning this reduced hierarchy, like the Lax flows and the Hamiltonians, are by now well understood, there still lacks a clear and conclusive statement about the associated Poisson structure. We fill this gap by placing the problem in a more general framework and then showing how the required result follows from an interesting property of the second Gelfand-Dickey brackets under multiplication and inversion of Lax operators. As a byproduct we give an elegant and simple proof of the generalised Kupershmidt-Wilson theorem.
Generalised action-angle coordinates defined on island chains
Dewar, Robert L; Gibson, Ashley M
2012-01-01
Straight-field-line coordinates are very useful for representing magnetic fields in toroidally confined plasmas, but fundamental problems arise regarding their definition in 3-D geometries because of the formation of islands and chaotic field regions, ie non-integrability. In Hamiltonian dynamical systems terms these coordinates are a form of action-angle variables, which are normally defined only for integrable systems. In order to describe 3-D magnetic field systems, a generalisation of this concept was proposed recently by the present authors that unified the concepts of ghost surfaces and quadratic-flux-minimising (QFMin) surfaces. This was based on a simple canonical transformation generated by a change of variable $\\theta = \\theta(\\Theta,\\zeta)$, where $\\theta$ and $\\zeta$ are poloidal and toroidal angles, respectively, with $\\Theta$ a new poloidal angle chosen to give pseudo-orbits that are a) straight when plotted in the $\\zeta,\\Theta$ plane and b) QFMin pseudo-orbits in the transformed coordinate. Th...
From Bethe-Salpeter Wave functions to Generalised Parton Distributions
Mezrag, C.; Moutarde, H.; Rodríguez-Quintero, J.
2016-09-01
We review recent works on the modelling of generalised parton distributions within the Dyson-Schwinger formalism. We highlight how covariant computations, using the impulse approximation, allows one to fulfil most of the theoretical constraints of the GPDs. Specific attention is brought to chiral properties and especially the so-called soft pion theorem, and its link with the Axial-Vector Ward-Takahashi identity. The limitation of the impulse approximation are also explained. Beyond impulse approximation computations are reviewed in the forward case. Finally, we stress the advantages of the overlap of lightcone wave functions, and possible ways to construct covariant GPD models within this framework, in a two-body approximation.
From Bethe-Salpeter Wave Functions to Generalised Parton Distributions
Mezrag, C; Rodriguez-Quintero, J
2016-01-01
We review recent works on the modelling of Generalised Parton Distributions within the Dyson-Schwinger formalism. We highlight how covariant computations, using the impulse approximation, allows one to fulfil most of the theoretical constraints of the GPDs. Specific attention is brought to chiral properties and especially the so-called soft pion theorem, and its link with the Axial-Vector Ward-Takahashi identity. The limitation of the impulse approximation are also explained. Beyond impulse approximation computations are reviewed in the forward case. Finally, we stress the advantages of the overlap of lightcone wave functions, and possible ways to construct covariant GPD models within this framework, in a two-body approximation.
Viability of variable generalised Chaplygin gas: a thermodynamical approach
Panigrahi, D.; Chatterjee, S.
2017-03-01
The viability of the variable generalised Chaplygin gas (VGCG) model is analysed from the standpoint of its thermodynamical stability criteria with the help of an equation of state, P = - B/ρ ^{α }, where B = B0V^{-n/3}. Here B0 is assumed to be a positive universal constant, n is a constant parameter and V is the volume of the cosmic fluid. We get the interesting result that if the well-known stability conditions of a fluid is adhered to, the values of n are constrained to be negative definite to make ( partial P/partial V) S caloric equation of state parameter when T → 0. It may also be mentioned that like Santos et al. our model does not admit of any critical points. We also observe that although the earlier model of Lu explains many of the current observational findings of different probes it fails to explain the crucial tests of thermodynamical stability.
Generalised integrable λ- and η-deformations and their relation
Konstantinos Sfetsos
2015-10-01
Full Text Available We construct two-parameter families of integrable λ-deformations of two-dimensional field theories. These interpolate between a CFT (a WZW/gauged WZW model and the non-Abelian T-dual of a principal chiral model on a group/symmetric coset space. In examples based on the SU(2 WZW model and the SU(2/U(1 exact coset CFT, we show that these deformations are related to bi-Yang–Baxter generalisations of η-deformations via Poisson–Lie T-duality and analytic continuation. We illustrate the quantum behaviour of our models under RG flow. As a byproduct we demonstrate that the bi-Yang–Baxter σ-model for a general group is one-loop renormalisable.
Visceral obesity and psychosocial stress: a generalised control theory model
Wallace, Rodrick
2016-07-01
The linking of control theory and information theory via the Data Rate Theorem and its generalisations allows for construction of necessary conditions statistical models of body mass regulation in the context of interaction with a complex dynamic environment. By focusing on the stress-related induction of central obesity via failure of HPA axis regulation, we explore implications for strategies of prevention and treatment. It rapidly becomes evident that individual-centred biomedical reductionism is an inadequate paradigm. Without mitigation of HPA axis or related dysfunctions arising from social pathologies of power imbalance, economic insecurity, and so on, it is unlikely that permanent changes in visceral obesity for individuals can be maintained without constant therapeutic effort, an expensive - and likely unsustainable - public policy.
Generalised two target localisation using passive monopulse radar
Jardak, Seifallah
2017-04-07
The simultaneous lobing technique, also known as monopulse technique, has been widely used for fast target localisation and tracking purposes. Many works focused on accurately localising one or two targets lying within a narrow beam centred around the monopulse antenna boresight. In this study, a new approach is proposed, which uses the outputs of four antennas to rapidly localise two point targets present in the hemisphere. If both targets have the same elevation angle, the proposed scheme cannot detect them. To detect such targets, a second set of antennas is required. In this study, to detect two targets at generalised locations, the antenna array is divided into multiple overlapping sets each of four antennas. Two algorithms are proposed to combine the outputs from multiple sets and improve the detection performance. Simulation results show that the algorithm is able to localise both targets with <;2° mean square error in azimuth and elevation.
Optimising, generalising and integrating educational practice using neuroscience
Colvin, Robert
2016-07-01
Practical collaboration at the intersection of education and neuroscience research is difficult because the combined discipline encompasses both the activity of microscopic neurons and the complex social interactions of teachers and students in a classroom. Taking a pragmatic view, this paper discusses three education objectives to which neuroscience can be effectively applied: optimising, generalising and integrating instructional techniques. These objectives are characterised by: (1) being of practical importance; (2) building on existing education and cognitive research; and (3) being infeasible to address based on behavioural experiments alone. The focus of the neuroscientific aspect of collaborative research should be on the activity of the brain before, during and after learning a task, as opposed to performance of a task. The objectives are informed by literature that highlights possible pitfalls with educational neuroscience research, and are described with respect to the static and dynamic aspects of brain physiology that can be measured by current technology.
Generalised pruritus as a presentation of Grave’s disease
Tan CE
2013-05-01
Full Text Available Pruritus is a lesser known symptom of hyperthyroidism, particularly in autoimmune thyroid disorders. This is a case report of a 27-year-old woman who presented with generalised pruritus at a primary care clinic. Incidental findings of tachycardia and a goiter led to the investigations of her thyroid status. The thyroid function test revealed elevated serum free T4 and suppressed thyroid stimulating hormone levels. The anti-thyroid antibodies were positive. She was diagnosed with Graves’ disease and treated with carbimazole until her symptoms subsided. Graves’ disease should be considered as an underlying cause for patients presenting with pruritus. A thorough history and complete physical examination are crucial in making an accurate diagnosis. Underlying causes must be determined before treating the symptoms.
Generalised partition functions: inferences on phase space distributions
Treumann, Rudolf A.; Baumjohann, Wolfgang
2016-06-01
It is demonstrated that the statistical mechanical partition function can be used to construct various different forms of phase space distributions. This indicates that its structure is not restricted to the Gibbs-Boltzmann factor prescription which is based on counting statistics. With the widely used replacement of the Boltzmann factor by a generalised Lorentzian (also known as the q-deformed exponential function, where κ = 1/|q - 1|, with κ, q ∈ R) both the kappa-Bose and kappa-Fermi partition functions are obtained in quite a straightforward way, from which the conventional Bose and Fermi distributions follow for κ → ∞. For κ ≠ ∞ these are subject to the restrictions that they can be used only at temperatures far from zero. They thus, as shown earlier, have little value for quantum physics. This is reasonable, because physical κ systems imply strong correlations which are absent at zero temperature where apart from stochastics all dynamical interactions are frozen. In the classical large temperature limit one obtains physically reasonable κ distributions which depend on energy respectively momentum as well as on chemical potential. Looking for other functional dependencies, we examine Bessel functions whether they can be used for obtaining valid distributions. Again and for the same reason, no Fermi and Bose distributions exist in the low temperature limit. However, a classical Bessel-Boltzmann distribution can be constructed which is a Bessel-modified Lorentzian distribution. Whether it makes any physical sense remains an open question. This is not investigated here. The choice of Bessel functions is motivated solely by their convergence properties and not by reference to any physical demands. This result suggests that the Gibbs-Boltzmann partition function is fundamental not only to Gibbs-Boltzmann but also to a large class of generalised Lorentzian distributions as well as to the corresponding nonextensive statistical mechanics.
A Dixmier-Moeglin equivalence for skew Laurent polynomial rings
Parks, James William Alexander
2009-01-01
The work of Dixmier in 1977 and Moeglin in 1980 show us that for a prime ideal $P$ in the universal enveloping algebra of a complex finite-dimensional Lie algebra the properties of being primitive, rational and locally closed in the Zariski topology are all equivalent. This equivalence is referred to as the Dixmier-Moeglin equivalence. In this thesis we will study skew Laurent polynomial rings of the form ${mathbb{C}}[x_1,ldots,x_d][z,z^{-1};sigma]$ where $sigma$ is a ${mathbb{C}}$-algebra au...
Noetherianity of some degree two twisted skew-commutative algebras
Nagpal, Rohit; Sam, Steven V; Snowden, Andrew
2016-01-01
A major open problem in the theory of twisted commutative algebras (tca's) is proving noetherianity of finitely generated tca's. For bounded tca's this is easy, in the unbounded case, noetherianity is only known for Sym(Sym^2(C^\\infty)) and Sym(\\wedge^2(C^\\infty)). In this paper, we establish noetherianity for the skew-commutative versions of these two algebras, namely \\wedge(Sym^2(C^\\infty)) and \\wedge(\\wedge^2(C^\\infty)). The result depends on work of Serganova on the representation theory ...
Light transmission for polymer fibers using skew and meridional rays
Tekelioglu, Murat
This dissertation is concerned with the development of a light transmission model for polymer optical fibers having application in hybrid solar lighting (HSL) systems. Conceptually, the HSL system consists of a solar collector/receiver that focuses concentrated visible solar light onto a polymer optical fiber (up to 10-m-long) that transports the solar light to an interior space. For this study, the polymer optical fiber is a large-core (0.2-40 mm diameter) plastic optical fiber (POF) comprised of various lengths of straight and bent sections. Although there has been extensive research on the transmission of monochromatic light through optical fibers for the communications industry, there are relatively few publications for visible light transmission through POFs. These publications were critically reviewed in this research. It is shown that the light transmission can be described with either skew or meridional rays. For each ray type, the HSL system light transmission was determined as a function of fiber geometrical properties (core and cladding radii, bend radius, bend angle, and fiber length) and optical properties (core and clad refractive indices, absorption and scattering coefficients, core-clad rms roughness height, and core-clad interface defects loss coefficient). To do this, first, models were developed for separate straight and bent sections for multiple skew and meridional rays. Second, the straight and bent models were combined into a FORTRAN simulation program for an arbitrary fiber with a combination of arbitrary straight and bent sections. The input condition of the rays (arrangement of rays, incident angle, and intensity profile) is user-defined. Third, the simulation results were experimentally validated using two different POFs, twelve configurations of straight and bent fiber subsystems, and two ray types. These experimental comparisons show that the transmission model using meridional rays is slightly better than that with the skew rays. But
Wigner-Yanase skew information as tests for quantum entanglement
Chen, Z
2004-01-01
A Bell-type inequality is proposed in terms of Wigner-Yanase skew information, which is quadratic and involves only one local spin observable at each site. This inequality presents a hierarchic classification of all states of multipartite quantum systems from separable to fully entangled states, which is more powerful than the one presented by quadratic Bell inequalities from 2-entangled to fully entangled states. In particular, it is proved that the inequality provides an exact test to distinguish entangled from nonentangled pure states of two qubits. Our inequality sheds considerable new light on relationships between quantum entanglement and information theory.
Forecasting stock market volatility: Do realized skewness and kurtosis help?
Mei, Dexiang; Liu, Jing; Ma, Feng; Chen, Wang
2017-09-01
In this study, we investigate the predictability of the realized skewness (RSK) and realized kurtosis (RKU) to stock market volatility, that has not been addressed in the existing studies. Out-of-sample results show that RSK, which can significantly improve forecast accuracy in mid- and long-term, is more powerful than RKU in forecasting volatility. Whereas these variables are useless in short-term forecasting. Furthermore, we employ the realized kernel (RK) for the robustness analysis and the conclusions are consistent with the RV measures. Our results are of great importance for portfolio allocation and financial risk management.
Detecting a Multi-Homed Device Using Clock Skew
2016-09-01
private network and the other to the open Internet, this provides a possible access vector that bypasses the network’s firewall [4]. This threat...the threat of a multi-homed host serving as an access vector to a network is to be mitigated by the ability to detect the presence of such a host...cannot be exactly measured or known. The clock skew is a random variable α that is assumed to be Gaussian with a density function f( ). A confidence
Willemse, W.J.; Kaas, R.
2007-01-01
A generalisation of Gompertz' distribution is proposed, and it is shown that continuous heterogeneous mortality models with Gamma distributed frailty have lifetime random variables distributed as the difference of two such generalised Gompertz random variables. With this result, limitations of exist
W.J. Willemse; R. Kaas
2007-01-01
A generalisation of Gompertz' distribution is proposed, and it is shown that continuous heterogeneous mortality models with Gamma distributed frailty have lifetime random variables distributed as the difference of two such generalised Gompertz random variables. With this result, limitations of exist
Shape and distribution of Jones and Faddy's skew t random variable
Saipornchai, N.
2005-09-01
Full Text Available The purpose of this research is to find another way to generate Jones and Faddy's skew t random variable and to construct quantile table, coefficient of skewness, coefficient of kurtosis and coefficient of variation tables of Jones and Faddy's skew t distribution. Graphs of its probability density function and graphs of its distribution function are also presented. The results of this study show that Jones and Faddy's skew t random variable can be generated from a beta random variable on (-1,1. The coefficients of skewness and kurtosis of the distribution depend on parameters a and b. The coefficient of variation of Jones and Faddy's skew t distribution can be calculated.
Skew cyclic codes over F_q+uF_q+vF_q+uvF_q
Ting Yao
2015-09-01
Full Text Available In this paper, we study skew cyclic codes over the ring $R=F_q+uF_q+vF_q+uvF_q$, where $u^{2}=u,v^{2}=v,uv=vu$, $q=p^{m}$ and $p$ is an odd prime. We investigate the structural properties of skew cyclic codes over $R$ through a decomposition theorem. Furthermore, we give a formula for the number of skew cyclic codes of length $n$ over $R.$
Multivariate log-skew-elliptical distributions with applications to precipitation data
Marchenko, Yulia V.
2009-07-13
We introduce a family of multivariate log-skew-elliptical distributions, extending the list of multivariate distributions with positive support. We investigate their probabilistic properties such as stochastic representations, marginal and conditional distributions, and existence of moments, as well as inferential properties. We demonstrate, for example, that as for the log-t distribution, the positive moments of the log-skew-t distribution do not exist. Our emphasis is on two special cases, the log-skew-normal and log-skew-t distributions, which we use to analyze US national (univariate) and regional (multivariate) monthly precipitation data. © 2009 John Wiley & Sons, Ltd.
Liu, Yufang; Zhang, Weiguo; Fu, Junhui
2016-11-01
This paper presents the Binomial Markov-switching Multifractal (BMSM) model of asset returns with Skewed t innovations (BMSM-Skewed t for short), which considers the fat tails, skewness and multifractality in asset returns simultaneously. The parameters of BMSM-Skewed t model can be estimated by Maximum Likelihood (ML) methods, and volatility forecasting can be accomplished via Bayesian updating. In order to evaluate the performance of BMSM-Skewed t model, BMSM model with Normal innovations (BMSM-N), BMSM model with Student-t innovations (BMSM-t) and GARCH(1,1) models (GARCH-N, GARCH-t and GARCH-Skewed t) are chosen for comparison. Through empirical studies on Shanghai Stock Exchange Composite Index (SSEC), we find that for sample estimation, BMSM models outperform the GARCH(1,1) models through BIC and AIC rules, and BMSM-Skewed t performs the best among all the models due to its fat tails, skewness and multifractality. In addition, BMSM-Skewed t model dominates other models at most forecasting horizons for out-of-sample volatility forecasts in terms of MSE, MAE and SPA test.
Judd, Linda J.; Asquith, William H.; Slade, Raymond M.
1996-01-01
This report presents two techniques to estimate generalized skew coefficients used for log-Pearson Type III peak-streamflow frequency analysis of natural basins in Texas. A natural basin has less than 10 percent impervious cover, and less than 10 percent of its drainage area is controlled by reservoirs. The estimation of generalized skew coefficients is based on annual peak and historical peak streamflow for all U.S. Geological Survey streamflow-gaging stations having at least 20 years of annual peak-streamflow record from natural basins in Texas. Station skew coefficients calculated for each of 255 Texas stations were used to estimate generalized skew coefficients for Texas.
Quality Assessment in River Network Generalisation by Preserving the Drainage Pattern
Zhang, L.; Guilbert, E.
2013-05-01
The drainage pattern of a river network is the arrangement in which a stream erodes the channels of its network of tributaries. It can reflect the geographical characteristics of a river network to a certain extent, because it depends on the topography and geology of the land. Whether in cartography or GIS, hydrography is one of the most important feature classes to generalise in order to produce representations at various levels of detail. Cartographic generalisation is an intricate process whereby information is selected and represented on a map at a certain scale, not necessarily preserving all geographical or other cartographic details. There are many methods for river network generalisation, but the generalized results are always inspected by expert cartographers visually. This paper proposes a method that evaluates the quality of a river network generalisation by assessing if drainage patterns are preserved. This method provides a quantitative value that estimates the membership of a river network in different drainage patterns. A set of geometric indicators describing each pattern are presented and the membership of a network is defined based on fuzzy logic. For each pattern, the fuzzy set membership is given by a defined IF-THEN rule composed of several indicators and logical operators. Assessing the quality of a generalisation is done by comparing and analysing the value before and after the network generalisation. This assessment method is tested with several river network generalisation methods on different sets of networks and results are analysed and discussed.
Generalised block bootstrap and its use in meteorology
Varga, László; Zempléni, András
2017-06-01
In an earlier paper, Rakonczai et al.(2014) emphasised the importance of investigating the effective sample size in case of autocorrelated data. The simulations were based on the block bootstrap methodology. However, the discreteness of the usual block size did not allow for exact calculations. In this paper we propose a new generalisation of the block bootstrap methodology, which allows for any positive real number as expected block size. We relate it to the existing optimisation procedures and apply it to a temperature data set. Our other focus is on statistical tests, where quite often the actual sample size plays an important role, even in the case of relatively large samples. This is especially the case for copulas. These are used for investigating the dependencies among data sets. As in quite a few real applications the time dependence cannot be neglected, we investigated the effect of this phenomenon on the used test statistic. The critical value can be computed by the proposed new block bootstrap simulation, where the block size is determined by fitting a VAR model to the observations. The results are illustrated for models of the used temperature data.
Sketching the pion's valence-quark generalised parton distribution
C. Mezrag
2015-02-01
Full Text Available In order to learn effectively from measurements of generalised parton distributions (GPDs, it is desirable to compute them using a framework that can potentially connect empirical information with basic features of the Standard Model. We sketch an approach to such computations, based upon a rainbow-ladder (RL truncation of QCD's Dyson–Schwinger equations and exemplified via the pion's valence dressed-quark GPD, Hπv(x,ξ,t. Our analysis focuses primarily on ξ=0, although we also capitalise on the symmetry-preserving nature of the RL truncation by connecting Hπv(x,ξ=±1,t with the pion's valence-quark parton distribution amplitude. We explain that the impulse-approximation used hitherto to define the pion's valence dressed-quark GPD is generally invalid owing to omission of contributions from the gluons which bind dressed-quarks into the pion. A simple correction enables us to identify a practicable improvement to the approximation for Hπv(x,0,t, expressed as the Radon transform of a single amplitude. Therewith we obtain results for Hπv(x,0,t and the associated impact-parameter dependent distribution, qπv(x,|b→⊥|, which provide a qualitatively sound picture of the pion's dressed-quark structure at a hadronic scale. We evolve the distributions to a scale ζ=2 GeV, so as to facilitate comparisons in future with results from experiment or other nonperturbative methods.
Integrable Hopf twists, marginal deformations and generalised geometry
Dlamini, Hector
2016-01-01
We study the symmetries of an N=1 superconformal marginal deformation of the N=4 SYM theory which depends on a real parameter w. It is a special case of the two-complex-parameter Leigh-Strassler family of superconformal deformations of N=4 SYM, which is one-loop planar-integrable. On the gauge theory side of the AdS/CFT correspondence, we construct the Hopf twist leading to the deformed global symmetry of the theory and use it to define a star product between its three scalar superfields. Turning to the gravity side of the correspondence, we adapt the above star product to deform the pure spinors of six-dimensional flat space in its generalised geometry description. This leads us to a new N=2 NS-NS solution of IIB supergravity. Starting from this precursor solution, adding D3-branes and taking the near-horizon limit leads us to an exact AdS_5x(S^5)_w solution which we conjecture to be the gravity dual of the w-deformed gauge theory. Unlike the dual to the beta-deformed Leigh-Strassler theory, the internal par...
Viability of Variable Generalised Chaplygin gas - a thermodynamical approach
Panigrahi, D
2016-01-01
The viability of the variable generalised Chaplygin gas (VGCG) model is analysed from the standpoint of its thermodynamical stability criteria with the help of an equation of state, $P = - \\frac{B}{\\rho^{\\alpha}}$, where $B = B_{0}V^{-\\frac{n}{3}}$. Here $B_{0}$ is assumed to be a positive universal constant, $n$ is a constant parameter and $V$ is the volume of the cosmic fluid. We get the interesting result that if the well-known stability conditions of a fluid is adhered to, the values of $n$ are constrained to be negative definite to make $ \\left(\\frac{\\partial P}{\\partial V}\\right)_{S} <0$ \\& $ \\left(\\frac{\\partial P}{\\partial V}\\right)_{T} <0$ throughout the evolution. Moreover the positivity of thermal capacity at constant volume $c_{V}$ as also the validity of the third law of thermodynamics are ensured in this case. For the particular case $n = 0$ the effective equation of state reduces to $\\Lambda$CDM model in the late stage of the universe while for $n <0$ it mimics a phantom-like cosmo...
Superstatistical generalisations of Wishart-Laguerre ensembles of random matrices
Abul-Magd, A Y; Vivo, P
2008-01-01
Using Beck and Cohen's superstatistics, we introduce in a systematic way a family of generalised Wishart-Laguerre ensembles of random matrices with Dyson index $\\beta$ = 1,2, and 4. The entries of the data matrix are Gaussian random variables whose variances $\\eta$ fluctuate from one sample to another according to a certain probability density $f(\\eta)$ and a single deformation parameter $\\gamma$. Three superstatistical classes for $f(\\eta)$ are usually considered: $\\chi^2$-, inverse $\\chi^2$- and log-normal-distribution. While the first class, already considered by two of the authors, leads to a power-law decay, we here introduce and solve exactly a superposition of Wishart-Laguerre ensembles with inverse $\\chi^2$- distribution. The corresponding macroscopic spectral density is given by a $\\gamma$-deformation of the semi-circle and Marcenko-Pastur laws, on a non-compact support with exponential tails. Using a Wigner surmise, we also compute the microscopic level spacing distribution, which displays a stretch...
Generalised geometrical CP violation in a T′ lepton flavour model
Girardi, Ivan [SISSA/INFN,Via Bonomea 265, I-34136 Trieste (Italy); Meroni, Aurora [SISSA/INFN,Via Bonomea 265, I-34136 Trieste (Italy); Dipartimento di Matematica e Fisica, Università di Roma Tre,Via della Vasca Navale 84, I-00146, Rome (Italy); INFN, Laboratori Nazionali di Frascati,Via E. Fermi 40, I-00044 Frascati (Italy); Petcov, S.T. [SISSA/INFN,Via Bonomea 265, I-34136 Trieste (Italy); IPMU, University of Tokyo,5-1-5 Kashiwanoha, 277-8583 Kashiwa (Japan); Spinrath, Martin [SISSA/INFN,Via Bonomea 265, I-34136 Trieste (Italy); Institut für Theoretische Teilchenphysik, Karlsruhe Institute of Technology,Engesserstraße 7, D-76131 Karlsruhe (Germany)
2014-02-12
We analyse the interplay of generalised CP transformations and the non-Abelian discrete group T′ and use the semi-direct product G{sub f}=T′⋊H{sub CP}, as family symmetry acting in the lepton sector. The family symmetry is shown to be spontaneously broken in a geometrical manner. In the resulting flavour model, naturally small Majorana neutrino masses for the light active neutrinos are obtained through the type I see-saw mechanism. The known masses of the charged leptons, lepton mixing angles and the two neutrino mass squared differences are reproduced by the model with a good accuracy. The model allows for two neutrino mass spectra with normal ordering (NO) and one with inverted ordering (IO). For each of the three spectra the absolute scale of neutrino masses is predicted with relatively small uncertainty. The value of the Dirac CP violation (CPV) phase δ in the lepton mixing matrix is predicted to be δ≅π/2 or 3π/2. Thus, the CP violating effects in neutrino oscillations are predicted to be maximal (given the values of the neutrino mixing angles) and experimentally observable. We present also predictions for the sum of the neutrino masses, for the Majorana CPV phases and for the effective Majorana mass in neutrinoless double beta decay. The predictions of the model can be tested in a variety of ongoing and future planned neutrino experiments.
Effects of Community African Drumming on Generalised Anxiety in Teenagers
David Akombo
2013-07-01
Full Text Available The purpose of this study was to test the effects of community music projects (CMPs, such as after-school African drumming circles, on academic performance and generalised anxiety in adolescents. Adolescents from a Junior High (7th, 8th, and 9th graders, age range from 12-14 in the State of Utah (USA participated in the study. A one-sample t-test found a significant difference in reading scores (df(4 p=.004. A paired samples t-test found a significant relationship between the maths trait anxiety score pre-intervention and the total state anxiety score pre-test (df(4 p=.033. A paired samples t-test found a significant relationship between the reading trait anxiety score post-intervention and the total state anxiety score post-test (df(4 p=.030. This research demonstrates the effectiveness of community music such as drumming for reducing anxiety and also for improving academic performance in adolescents. CMPs are recommended as a non-invasive intervention modality for adolescents.
Interpretation of human pointing by African elephants: generalisation and rationality.
Smet, Anna F; Byrne, Richard W
2014-11-01
Factors influencing the abilities of different animals to use cooperative social cues from humans are still unclear, in spite of long-standing interest in the topic. One of the few species that have been found successful at using human pointing is the African elephant (Loxodonta africana); despite few opportunities for learning about pointing, elephants follow a pointing gesture in an object-choice task, even when the pointing signal and experimenter's body position are in conflict, and when the gesture itself is visually subtle. Here, we show that the success of captive African elephants at using human pointing is not restricted to situations where the pointing signal is sustained until the time of choice: elephants followed human pointing even when the pointing gesture was withdrawn before they had responded to it. Furthermore, elephants rapidly generalised their response to a type of social cue they were unlikely to have seen before: pointing with the foot. However, unlike young children, they showed no sign of evaluating the 'rationality' of this novel pointing gesture according to its visual context: that is, whether the experimenter's hands were occupied or not.
Some generalisations of linear-graph modelling for dynamic systems
de Silva, Clarence W.; Pourazadi, Shahram
2013-11-01
Proper modelling of a dynamic system can benefit analysis, simulation, design, evaluation and control of the system. The linear-graph (LG) approach is suitable for modelling lumped-parameter dynamic systems. By using the concepts of graph trees, it provides a graphical representation of the system, with a direct correspondence to the physical component topology. This paper systematically extends the application of LGs to multi-domain (mixed-domain or multi-physics) dynamic systems by presenting a unified way to represent different domains - mechanical, electrical, thermal and fluid. Preservation of the structural correspondence across domains is a particular advantage of LGs when modelling mixed-domain systems. The generalisation of Thevenin and Norton equivalent circuits to mixed-domain systems, using LGs, is presented. The structure of an LG model may follow a specific pattern. Vector LGs are introduced to take advantage of such patterns, giving a general LG representation for them. Through these vector LGs, the model representation becomes simpler and rather compact, both topologically and parametrically. A new single LG element is defined to facilitate the modelling of distributed-parameter (DP) systems. Examples are presented using multi-domain systems (a motion-control system and a flow-controlled pump), a multi-body mechanical system (robot manipulator) and DP systems (structural rods) to illustrate the application and advantages of the methodologies developed in the paper.
Sketching the pion's valence-quark generalised parton distribution
Mezrag, C; Moutarde, H; Roberts, C D; Rodriguez-Quintero, J; Sabatie, F; Schmidt, S M
2014-01-01
In order to learn effectively from measurements of generalised parton distributions (GPDs), it is desirable to compute them using a framework that can potentially connect empirical information with basic features of the Standard Model. We sketch an approach to such computations, based upon a rainbow-ladder (RL) truncation of QCD's Dyson-Schwinger equations and exemplified via the pion's valence dressed-quark GPD, $H_\\pi^{\\rm v}(x,\\xi,t)$. Our analysis focuses primarily on $\\xi=0$, although we also capitalise on the symmetry-preserving nature of the RL truncation by connecting $H_\\pi^{\\rm v}(x,\\xi=\\pm 1,t)$ with the pion's valence-quark parton distribution amplitude. We explain that the impulse-approximation used hitherto to define the pion's valence dressed-quark GPD is generally invalid owing to omission of contributions from the gluons which bind dressed-quarks into the pion. A simple correction enables us to identify a practicable improvement to the approximation for $H_\\pi^{\\rm v}(x,0,t)$, expressed as th...
Skewed birth sex ratio and premature mortality in elephants.
Saragusty, Joseph; Hermes, Robert; Göritz, Frank; Schmitt, Dennis L; Hildebrandt, Thomas B
2009-10-01
Sex allocation theories predict equal offspring number of both sexes unless differential investment is required or some competition exists. Left undisturbed, elephants reproduce well and in approximately even numbers in the wild. We report an excess of males are born and substantial juvenile mortality occurs, perinatally, in captivity. Studbook data on captive births (CB, n=487) and premature deaths (PD, 6 months with maternal insufficient milk production, natural hazards and accidents being the main causes. European Asian and Myanmar elephants PD was biased towards males (0.71, P=0.024 and 0.56, P<0.001, respectively). The skewed birth sex ratio and high juvenile mortality hinder efforts to help captive populations become self-sustaining. Efforts should be invested to identify the mechanism behind these trends and seek solutions for them.
On skew tau-functions in higher spin theory
Melnikov, D; Morozov, A
2016-01-01
Recent studies of higher spin theory in three dimensions concentrate on Wilson loops in Chern-Simons theory, which in the classical limit reduce to peculiar corner matrix elements between the highest and lowest weight states in a given representation of SL(N). Despite these "skew" tau-functions can seem very different from conventional ones, which are the matrix elements between the two highest weight states, they also satisfy the Toda recursion between different fundamental representations. Moreover, in the most popular examples they possess simple representations in terms of matrix models and Schur functions. We provide a brief introduction to this new interesting field, which, after quantization, can serve as an additional bridge between knot and integrability theories.
Patterns of paternity skew among polyandrous social insects
Jaffé, Rodolfo; Garcia-Gonzalez, Francisco; den Boer, Susanne
2012-01-01
Monogamy results in high genetic relatedness among offspring and thus it is generally assumed to be favored by kin selection. Female multiple mating (polyandry) has nevertheless evolved several times in the social Hymenoptera (ants, bees, and wasps), and a substantial amount of work has been...... conducted to understand its costs and benefits. Relatedness and inclusive fitness benefits are, however, not only influenced by queen mating frequency but also by paternity skew, which is a quantitative measure of paternity biases among the offspring of polyandrous females. We performed a large...... the potential for postcopulatory sexual selection to influence patterns of paternity in social insects, and suggest that sexual selection may have played a key, yet overlooked role in social evolution....
Skewed gas flow technology offers antidote to opacity derates
Boyd, M. [ATCO Power AB (Canada). Battle River Generating Station
2001-06-01
Deratings due to opacity problems at the Battle River Generating Station in Alberta, Canada led ATCO Power to evaluate and install skewed gas flow technology (SGFT) in one-half of the Unit 5 twin-casing electrostatic precipitator during the August 2000 outage. Preliminary operating results show that the modified casing produces opacity readings at the outlet 40% lower than those seen at the outlet of the unmodified casing. The dust loading tests indicate a 27.5% improvement in collector efficiency. This article includes a technical review and evaluation of Battle River's SGFT installation, as well as the rationale used to provide the initial economic justification. 3 figs., 1 tab., 1 photo.
Soft bounds on diffusion produce skewed distributions and Gompertz growth
Mandrà, Salvatore; Lagomarsino, Marco Cosentino; Gherardi, Marco
2014-09-01
Constraints can affect dramatically the behavior of diffusion processes. Recently, we analyzed a natural and a technological system and reported that they perform diffusion-like discrete steps displaying a peculiar constraint, whereby the increments of the diffusing variable are subject to configuration-dependent bounds. This work explores theoretically some of the revealing landmarks of such phenomenology, termed "soft bound." At long times, the system reaches a steady state irreversibly (i.e., violating detailed balance), characterized by a skewed "shoulder" in the density distribution, and by a net local probability flux, which has entropic origin. The largest point in the support of the distribution follows a saturating dynamics, expressed by the Gompertz law, in line with empirical observations. Finally, we propose a generic allometric scaling for the origin of soft bounds. These findings shed light on the impact on a system of such "scaling" constraint and on its possible generating mechanisms.
Julia Sets of Skew Products for Class MAp
王升
2004-01-01
Let fj ∈ M (j = 1, 2, …, m; m≥ 1) and （～f） be the skew product associated with the generator system {f1, f2, …, fm}. Then F （～f） is completely invariant under （～f）; J(（～f） is completely invariant under （～f）; J （～f） is perfect; J （～f） has interior points if and only if F （～f） = φ; if fj ∈ MAp (p ≥ 5), j =1, 2, …, m, then the set of the repelling fixed points of （～f） of all orders are dense in J （～f）.
Skew-orthogonal polynomials and random matrix theory
Ghosh, Saugata
2009-01-01
Orthogonal polynomials satisfy a three-term recursion relation irrespective of the weight function with respect to which they are defined. This gives a simple formula for the kernel function, known in the literature as the Christoffel-Darboux sum. The availability of asymptotic results of orthogonal polynomials and the simple structure of the Christoffel-Darboux sum make the study of unitary ensembles of random matrices relatively straightforward. In this book, the author develops the theory of skew-orthogonal polynomials and obtains recursion relations which, unlike orthogonal polynomials, depend on weight functions. After deriving reduced expressions, called the generalized Christoffel-Darboux formulas (GCD), he obtains universal correlation functions and non-universal level densities for a wide class of random matrix ensembles using the GCD. The author also shows that once questions about higher order effects are considered (questions that are relevant in different branches of physics and mathematics) the ...
Evolution of cooperation and skew under imperfect information.
Akçay, Erol; Meirowitz, Adam; Ramsay, Kristopher W; Levin, Simon A
2012-09-11
The evolution of cooperation in nature and human societies depends crucially on how the benefits from cooperation are divided and whether individuals have complete information about their payoffs. We tackle these questions by adopting a methodology from economics called mechanism design. Focusing on reproductive skew as a case study, we show that full cooperation may not be achievable due to private information over individuals' outside options, regardless of the details of the specific biological or social interaction. Further, we consider how the structure of the interaction can evolve to promote the maximum amount of cooperation in the face of the informational constraints. Our results point to a distinct avenue for investigating how cooperation can evolve when the division of benefits is flexible and individuals have private information.
Generalised Multi-sequence Shift-Register Synthesis using Module Minimisation
Nielsen, Johan Sebastian Rosenkilde
2013-01-01
We show how to solve a generalised version of the Multi-sequence Linear Feedback Shift-Register (MLFSR) problem using minimisation of free modules over F[x]. We show how two existing algorithms for minimising such modules run particularly fast on these instances. Furthermore, we show how one...... of them can be made even faster for our use. With our modelling of the problem, classical algebraic results tremendously simplify arguing about the algorithms. For the non-generalised MLFSR, these algorithms are as fast as what is currently known. We then use our generalised MLFSR to give a new fast...
Derivatization of carbohydrates for GC and GC-MS analyses.
Ruiz-Matute, A I; Hernández-Hernández, O; Rodríguez-Sánchez, S; Sanz, M L; Martínez-Castro, I
2011-05-15
GC and GC-MS are excellent techniques for the analysis of carbohydrates; nevertheless the preparation of adequate derivatives is necessary. The different functional groups that can be found and the diversity of samples require specific methods. This review aims to collect the most important methodologies currently used, either published as new procedures or as new applications, for the analysis of carbohydrates. A high diversity of compounds with diverse functionalities has been selected: neutral carbohydrates (saccharides and polyalcohols), sugar acids, amino and iminosugars, polysaccharides, glycosides, glycoconjugates, anhydrosugars, difructose anhydrides and products resulting of Maillard reaction (osuloses, Amadori compounds). Chiral analysis has also been considered, describing the use of diastereomers and derivatives to be eluted on chiral stationary phases.
The Generalised Ecosystem Modelling Approach in Radiological Assessment
Klos, Richard
2008-03-15
An independent modelling capability is required by SSI in order to evaluate dose assessments carried out in Sweden by, amongst others, SKB. The main focus is the evaluation of the long-term radiological safety of radioactive waste repositories for both spent fuel and low-level radioactive waste. To meet the requirement for an independent modelling tool for use in biosphere dose assessments, SSI through its modelling team CLIMB commissioned the development of a new model in 2004, a project to produce an integrated model of radionuclides in the landscape. The generalised ecosystem modelling approach (GEMA) is the result. GEMA is a modular system of compartments representing the surface environment. It can be configured, through water and solid material fluxes, to represent local details in the range of ecosystem types found in the past, present and future Swedish landscapes. The approach is generic but fine tuning can be carried out using local details of the surface drainage system. The modular nature of the modelling approach means that GEMA modules can be linked to represent large scale surface drainage features over an extended domain in the landscape. System change can also be managed in GEMA, allowing a flexible and comprehensive model of the evolving landscape to be constructed. Environmental concentrations of radionuclides can be calculated and the GEMA dose pathway model provides a means of evaluating the radiological impact of radionuclide release to the surface environment. This document sets out the philosophy and details of GEMA and illustrates the functioning of the model with a range of examples featuring the recent CLIMB review of SKB's SR-Can assessment
Work and entropy production in generalised Gibbs ensembles
Perarnau-Llobet, Martí; Riera, Arnau; Gallego, Rodrigo; Wilming, Henrik; Eisert, Jens
2016-12-01
Recent years have seen an enormously revived interest in the study of thermodynamic notions in the quantum regime. This applies both to the study of notions of work extraction in thermal machines in the quantum regime, as well as to questions of equilibration and thermalisation of interacting quantum many-body systems as such. In this work we bring together these two lines of research by studying work extraction in a closed system that undergoes a sequence of quenches and equilibration steps concomitant with free evolutions. In this way, we incorporate an important insight from the study of the dynamics of quantum many body systems: the evolution of closed systems is expected to be well described, for relevant observables and most times, by a suitable equilibrium state. We will consider three kinds of equilibration, namely to (i) the time averaged state, (ii) the Gibbs ensemble and (iii) the generalised Gibbs ensemble, reflecting further constants of motion in integrable models. For each effective description, we investigate notions of entropy production, the validity of the minimal work principle and properties of optimal work extraction protocols. While we keep the discussion general, much room is dedicated to the discussion of paradigmatic non-interacting fermionic quantum many-body systems, for which we identify significant differences with respect to the role of the minimal work principle. Our work not only has implications for experiments with cold atoms, but also can be viewed as suggesting a mindset for quantum thermodynamics where the role of the external heat baths is instead played by the system itself, with its internal degrees of freedom bringing coarse-grained observables to equilibrium.
Simple skew category algebras associated with minimal partially defined dynamical systems
Nystedt, Patrik; Öinert, Per Johan
2013-01-01
In this article, we continue our study of category dynamical systems, that is functors s from a category G to Topop, and their corresponding skew category algebras. Suppose that the spaces s(e), for e∈ob(G), are compact Hausdorff. We show that if (i) the skew category algebra is simple, then (ii) G...
Experimental study of the turbulent boundary layer in acceleration-skewed oscillatory flow
A, van der D.A.; O'Donoghue, T.; Davies, A.G.; Ribberink, J.S.
2011-01-01
Experiments have been conducted in a large oscillatory flow tunnel to investigate the effects of acceleration skewness on oscillatory boundary layer flow over fixed beds. As well as enabling experimental investigation of the effects of acceleration skewness, the new experiments add substantially to
The asymptotic distributions of the statistics of the skew elliptical variables
FANG Biqi
2005-01-01
In this paper, the asymptotic properties of the quadratic forms and the T statistic of the skew elliptical variables are studied. Consistent estimators of some parameters are obtained. The robustness of the significance level of the one-sided t test within the family of the skew normal family is investigated.
Likelihood Inference of Nonlinear Models Based on a Class of Flexible Skewed Distributions
Xuedong Chen
2014-01-01
Full Text Available This paper deals with the issue of the likelihood inference for nonlinear models with a flexible skew-t-normal (FSTN distribution, which is proposed within a general framework of flexible skew-symmetric (FSS distributions by combining with skew-t-normal (STN distribution. In comparison with the common skewed distributions such as skew normal (SN, and skew-t (ST as well as scale mixtures of skew normal (SMSN, the FSTN distribution can accommodate more flexibility and robustness in the presence of skewed, heavy-tailed, especially multimodal outcomes. However, for this distribution, a usual approach of maximum likelihood estimates based on EM algorithm becomes unavailable and an alternative way is to return to the original Newton-Raphson type method. In order to improve the estimation as well as the way for confidence estimation and hypothesis test for the parameters of interest, a modified Newton-Raphson iterative algorithm is presented in this paper, based on profile likelihood for nonlinear regression models with FSTN distribution, and, then, the confidence interval and hypothesis test are also developed. Furthermore, a real example and simulation are conducted to demonstrate the usefulness and the superiority of our approach.
Torque ripple minimization in a doubly salient permanent magnet motors by skewing the rotor teeth
Sheth, N. K.; Sekharbabu, A. R. C.; Rajagopal, K. R.
2006-09-01
This paper presents the effects of skewing the rotor teeth on the performance of an 8/6 doubly salient permanent magnet motor using a simple method, which utilizes the results obtained from the 2-D FE analysis. The optimum skewing angle is obtained as 12-15° for the least ripple torque without much reduction in the back-emf.
Assessment of seismic performance of skew reinforced concrete box girder bridges
Abdel-Mohti, Ahmed; Pekcan, Gokhan
2013-12-01
The seismic vulnerability of highway bridges remains an important problem and has received increased attention as a consequence of unprecedented damage observed during several major earthquakes. A significant number of research studies have examined the performance of skew bridges under service and seismic loads. The results of these studies are particularly sensitive to modeling assumptions in view of the interacting parameters. In the present study, three-dimensional improved beam-stick models of two-span highway bridges with skew angles varying from 0° to 60° are developed to investigate the seismic response characteristics of skew box girder bridges. The relative accuracy of beam-stick models is verified against counterpart finite element models. The effect of various parameters and conditions on the overall seismic response was examined such as skew angle, ground motion intensity, soil condition, abutment support conditions, bridge aspect ratio, and foundation-base conditions. The study shows that the improved beam-stick models can be used to conduct accurate nonlinear time history analysis of skew bridges. Skew angle and interacting parameters were found to have significant effect on the behavior of skewed highway bridges. Furthermore, the performance of shear keys may have a predominant effect on the overall seismic response of the skew bridges.
Does Realized Skewness Predict the Cross-Section of Equity Returns?
Amaya, Diego; Christoffersen, Peter; Jacobs, Kris
2015-01-01
We use intraday data to compute weekly realized moments for equity returns and study their time-series and cross-sectional properties. Buying stocks in the lowest realized skewness decile and selling stocks in the highest realized skewness decile generates an average return of 19 basis points the...
Smeets, T. J. L.; Jessurun, N.; Harmark, L.; Kardaun, S. H.
2016-01-01
Acute generalised exanthematous pustulosis (AGEP) is a rare but serious cutaneous adverse drug reaction, often related to antibiotics such as beta- lactams or macrolides. However, it is rarely associated with clindamycin which belongs to the lincosamide antibiotics. The Netherlands Pharmacovigilance
HITCHCOCK, ELAINE R.; BYUN, TARA McALLISTER
2014-01-01
Biofeedback intervention can help children achieve correct production of a treatment-resistant error sound, but generalisation is often limited. This case study suggests that generalisation can be enhanced when biofeedback intervention is structured in accordance with a “challenge point” framework for speech-motor learning. The participant was an 11-year-old with residual /r/ misarticulation who had previously attained correct /r/ production through a structured course of ultrasound biofeedback treatment but did not generalise these gains beyond the word level. Treatment difficulty was adjusted in an adaptive manner following predetermined criteria for advancing, maintaining, or moving back a level in a multidimensional hierarchy of functional task complexity. The participant achieved and maintained virtually 100% accuracy in producing /r/ at both word and sentence levels. These preliminary results support the efficacy of a semi-structured implementation of the challenge point framework as a means of achieving generalisation and maintenance of treatment gains. PMID:25216375
Hitchcock, Elaine R; Byun, Tara McAllister
2015-01-01
Biofeedback intervention can help children achieve correct production of a treatment-resistant error sound, but generalisation is often limited. This case study suggests that generalisation can be enhanced when biofeedback intervention is structured in accordance with a "challenge point" framework for speech-motor learning. The participant was an 11-year-old with residual /r/ misarticulation who had previously attained correct /r/ production through a structured course of ultrasound biofeedback treatment but did not generalise these gains beyond the word level. Treatment difficulty was adjusted in an adaptive manner following predetermined criteria for advancing, maintaining, or moving back a level in a multidimensional hierarchy of functional task complexity. The participant achieved and maintained virtually 100% accuracy in producing /r/ at both word and sentence levels. These preliminary results support the efficacy of a semi-structured implementation of the challenge point framework as a means of achieving generalisation and maintenance of treatment gains.
A generalisation of classical electrodynamics for the prediction of scalar field effects
van Vlaenderen, K J
2003-01-01
Within the framework of Classical Electrodynamics (CED) it is common practice to choose freely an arbitrary gauge condition with respect to a gauge transformation of the electromagnetic potentials. The Lorenz gauge condition allows for the derivation of the inhomogeneous potential wave equations (IPWE), but this also means that scalar derivatives of the electromagnetic potentials are considered to be \\emph{unphysical}. However, these scalar expressions might have the meaning of a new physical field, $\\mathsf S$. If this is the case, then a generalised CED is required such that scalar field effects are predicted and such that experiments can be performed in order to verify or falsify this generalised CED. The IPWE are viewed as a generalised Gauss law and a generalised Ampe\\`re law, that also contain derivatives of $\\mathsf S$, after reformulating the IPWE in terms of fields. Some recent experiment show positive results that are in qualitative agreement with the presented predictions of scalar field effects, b...
Lü, H; Stelle, Kellogg S
2006-01-01
The notion of {\\it generalised structure groups} and {\\it generalised holonomy groups} has been introduced in supergravity, in order to discuss the spinor rotations generated by commutators of supercovariant derivatives when non-vanishing form fields are included, with their associated gamma-matrix structures that go beyond the usual \\Gamma_{MN} of the Riemannian connection. In this paper we investigate the generalisations to the usual Riemannian structure and holonomy groups that result from the inclusion of higher-order string or M-theory corrections in the supercovariant derivative. Even in the absence of background form fields, these corrections introduce additional terms \\Gamma_{M_1... M_6} in the supercovariant connection, and hence they lead to enlarged structure and holonomy groups. In some cases, the corrected equations of motion force form fields to become non-zero too, which can further enlarge the groups. Our investigation focuses on the generalised structure and holonomy groups in the transverse ...
Generalised Measures of Useful Directed Divergence and Information Improvement with Applications
D.S. Hooda
2004-04-01
Full Text Available The present communication describes a new generalised measure of useful directed divergence based on m-l probability distributions, and a probability distribution closest to these probability distributions has been proposed. The technique has been applied in solving problems related to crops production, export, and industries. Further, a generalised measure of useful information improvement has been developed and its applications in the assessment of balanced military requirements for a country, in ranking and pattern recognition, have been discussed.
Neoclassical versus Frontier Production Models ? Testing for the Skewness of Regression Residuals
Kuosmanen, T; Fosgerau, Mogens
2009-01-01
The empirical literature on production and cost functions is divided into two strands. The neoclassical approach concentrates on model parameters, while the frontier approach decomposes the disturbance term to a symmetric noise term and a positively skewed inefficiency term. We propose a theoreti......The empirical literature on production and cost functions is divided into two strands. The neoclassical approach concentrates on model parameters, while the frontier approach decomposes the disturbance term to a symmetric noise term and a positively skewed inefficiency term. We propose...... a theoretical justification for the skewness of the inefficiency term, arguing that this skewness is the key testable hypothesis of the frontier approach. We propose to test the regression residuals for skewness in order to distinguish the two competing approaches. Our test builds directly upon the asymmetry...
Simultaneous Optimization of Skew and Control Step Assignments in RT-Datapath Synthesis
Obata, Takayuki; Kaneko, Mineo
As well as the schedule affects system performance, the control skew, i.e., the arrival time difference of control signals between registers, can be utilized for improving the system performance, enhancing robustness against delay variations, etc. The simultaneous optimization of the control step assignment and the control skew assignment is more powerful technique in improving performance. In this paper, firstly, we prove that, even if the execution sequence of operations which are assigned to the same resource is fixed, the simultaneous optimization problem under a fixed clock period is NP-hard. Secondly, we propose a heuristic algorithm for the simultaneous control step and skew optimization under given clock period, and we show how much the simultaneous optimization improves system performance. This paper is the first one that uses the intentional skew to shorten control steps under a specified clock period. The proposed algorithm has the potential to play a central role in various scenarios of skew-aware high level synthesis.
A proof for Rhiel's range estimator of the coefficient of variation for skewed distributions.
Rhiel, G Steven
2007-02-01
In this research study is proof that the coefficient of variation (CV(high-low)) calculated from the highest and lowest values in a set of data is applicable to specific skewed distributions with varying means and standard deviations. Earlier Rhiel provided values for d(n), the standardized mean range, and a(n), an adjustment for bias in the range estimator of micro. These values are used in estimating the coefficient of variation from the range for skewed distributions. The d(n) and an values were specified for specific skewed distributions with a fixed mean and standard deviation. In this proof it is shown that the d(n) and an values are applicable for the specific skewed distributions when the mean and standard deviation can take on differing values. This will give the researcher confidence in using this statistic for skewed distributions regardless of the mean and standard deviation.
Quantitative analysis of Boehm's GC
GUAN Xue-tao; ZHANG Yuan-rui; GOU Xiao-gang; CHENG Xu
2003-01-01
The term garbage collection describes the automated process of finding previously allocated memorythatis no longer in use in order to make the memory available to satisfy subsequent allocation requests. Wehave reviewed existing papers and implementations of GC, and especially analyzed Boehm' s C codes, which isa real-time mark-sweep GC running under Linux and ANSI C standard. In this paper, we will quantitatively an-alyze the performance of different configurations of Boehm' s collector subjected to different workloads. Reportedmeasurements demonstrate that a refined garbage collector is a viable alternative to traditional explicit memorymanagement techniques, even for low-level languages. It is more a trade-off for certain system than an all-or-nothing proposition.
An ontology for the generalisation of the bathymetry on nautical charts
Yan, J.; Guilbert, E.; Saux, E.
2014-11-01
On nautical charts, undersea features are portrayed by sets of soundings (depth points) and isobaths (depth contours) from which map readers can interpret landforms. Different techniques were developed for automatic soundings selection and isobath generalisation from a sounding set. These methods are mainly used to generate a new chart from the bathymetric database or from a large scale chart through selection and simplification however a part of the process consists in selecting and emphasising undersea features on the chart according to their relevance to navigation. Its automation requires classification of the features from the set of isobaths and soundings and their generalisation through the selection and application of a set of operators according not only to geometrical constraints but also to semantic constraints. The objective of this paper is to define an ontology formalising undersea feature representation and the generalisation process achieving this representation on a nautical chart. The ontology is built in two parts addressing on one hand the definition of the features and on the other hand their generalisation. The central concept is the undersea feature around which other concepts are organised. The generalisation process is driven by the features where the objective is to select or emphasise information according to their meaning for a specific purpose. The ontologies were developed in Protégé and a bathymetric database server integrating the ontology was implemented. A generalisation platform was also developed and examples of representations obtained by the platform are presented. Finally, current results and on-going research are discussed.
On flux vacua, SU(n)-structures and generalised complex geometry
Prins, Daniël
2016-01-01
Understanding supersymmetric flux vacua is essential in order to connect string theory to observable physics. In this thesis, flux vacua are studied by making use of two mathematical frameworks: SU(n)-structures and generalised complex geometry. Manifolds with SU(n)-structure are generalisations of Calabi-Yau manifolds. Generalised complex geometry is a geometrical framework that simultaneously generalises complex and symplectic geometry. Classes of flux vacua of type II supergravity and M-theory are given on manifolds with SU(4)-structure. The N= (1,1) type IIA vacua uplift to N=1 M-theory vacua, with four-flux that need not be (2,2) and primitive. Explicit vacua are given on Stenzel space, a non-compact Calabi-Yau. These are then generalised by constructing families of non-CY SU(4)-structures to find vacua on non-symplectic SU(4)-deformed Stenzel spaces. It is shown that the supersymmetry conditions for N = (2,0) type IIB can be rephrased in the language of generalised complex geometry, partially in terms o...
Ishido, Naoko; Inoue, Naoya; Watanabe, Mikio; Hidaka, Yoh
2015-01-01
Background: Autoimmune thyroid diseases (AITDs) predominantly develop in females. One of two X chromosomes is randomly inactivated by methylation in each female cell, but it has been reported that skewed X chromosome inactivation (XCI) may be associated with the development of autoimmune diseases. To clarify the significance of skewed XCI in the prognosis and development of AITD, we investigated the proportion of skewed XCI in female patients with AITD. Methods: We analyzed the degree of XCI skewing in 120 female patients with AITD (77 patients with Graves' disease [GD] and 43 patients with Hashimoto's disease [HD]) and 49 female controls in DNA from peripheral blood mononuclear cells (PBMC). We performed XCI analysis by digesting inactive DNA with a methylation-sensitive restriction enzyme (HpaII) followed by a polymerase chain reaction (PCR) assay for the polymorphic CAG repeat of the androgen receptor gene and electrophoresis of the PCR products. Results: The proportion of skewed XCI (≥65% skewing) was not significantly different between AITD patients and control subjects but was higher in patients with intractable GD (66.7%) than those with GD in remission (25.0%, p=0.0033) and control subjects (32.6%, p=0.0038). When the cutoff value for XCI skewing was relaxed, the proportion of skewed XCI (≥60% skewing) was higher in patients with severe HD (76.5%) than in those with mild HD (41.2%, p=0.0342). Conclusions: Skewed XCI is related to the prognosis of AITD, particularly the intractability of GD. PMID:25338305
Skewness of cloud droplet spectrum and an improved estimation for its relative dispersion
Liu, Yu; Lu, Chunsong; Li, Weiliang
2017-02-01
The relative dispersion of the cloud droplet spectrum is a very important parameter in describing and modeling cloud microphysical processes. Based on the definition of skewness as well as theoretical and data analyses, a linear fitting relationship ( α = 2.91 ɛ-0.59) between skewness ( α) and relative dispersion ( ɛ) is established and a new method is developed to estimate the relative dispersion of the cloud droplet spectrum. The new method does not depend on any assumption of a particular distribution for the cloud droplet spectrum and has broader applicability than the previous methods. Comparisons of the three methods for the relative dispersion with the observed data supported the following conclusions. (1) The skewness of the cloud droplet spectrum is asymmetrically distributed. An assumption of zero skewness in quantifying the relative dispersion inevitably results in relatively large deviations from the observations. Errors of the estimated relative dispersion due to the omission of the skewness term are not solely related to the skewness, but rather to the product of the skewness and relative dispersion. (2) The use of the assumption that the cloud droplet spectrum takes a gamma distribution is similar to the assumption that the skewness is twice the relative dispersion. This leads to a better accuracy in estimating the relative dispersion than that with zero skewness assumption. (3) Comparisons with observations show that the new method is more accurate than the one under gamma distribution assumption and is the best among all the three methods. (4) It is believed that finding a better correlation between the skewness and the relative dispersion would further reduce the deviations for the estimated relative dispersion.
Refractory generalised convulsive status epilepticus : a guide to treatment.
Kälviäinen, Reetta; Eriksson, Kai; Parviainen, Ilkka
2005-01-01
The patient with status epilepticus has continuous or rapidly repeating seizures. Generalised convulsive status epilepticus (GCSE) is the most common form of the disorder and is a life-threatening condition that requires prompt medical management. Status epilepticus that does not respond to first-line benzodiazepines (lorazepam or diazepam) or to second-line antiepileptic drugs (phenytoin/fosphenytoin, phenobarbital or valproate) is usually considered refractory and requires more aggressive treatment. The optimal treatment of refractory GCSE has not been defined, but patients should be treated in an intensive care unit, as artificial ventilation and haemodynamic support are required. Invasive haemodynamic monitoring is often necessary and EEG monitoring is essential. The drug treatment of refractory GCSE involves general anaesthesia with continuous intravenous anaesthetics given in doses that abolish all clinical and electrographic epileptic activity, often requiring sedation to the point of burst suppression on the EEG. Barbiturate anaesthetics, pentobarbital in the US and thiopental sodium in Europe and Australia, are the most frequently used agents and are highly effective for refractory GCSE both in children and adults. Indeed, they remain the only way to stop seizure activity with certainty in severely refractory cases. Other options are midazolam for adults and children and propofol for adults only.Regardless of the drug selected, intravenous fluids and vasopressors are usually required to treat hypotension. Once seizures have been controlled for 12-24 hours, continuous intravenous therapy should be gradually tapered off if the drug being administered is midazolam or propofol. Gradual tapering is probably not necessary with pentobarbital or thiopental sodium. Continuous EEG monitoring is required during high-dose treatment and while therapy is gradually withdrawn. During withdrawal of anaesthetic therapy, intravenous phenytoin/fosphenytoin or valproate should
Skew redundant MEMS IMU calibration using a Kalman filter
Jafari, M.; Sahebjameyan, M.; Moshiri, B.; Najafabadi, T. A.
2015-10-01
In this paper, a novel calibration procedure for skew redundant inertial measurement units (SRIMUs) based on micro-electro mechanical systems (MEMS) is proposed. A general model of the SRIMU measurements is derived which contains the effects of bias, scale factor error and misalignments. For more accuracy, the effect of lever arms of the accelerometers to the center of the table are modeled and compensated in the calibration procedure. Two separate Kalman filters (KFs) are proposed to perform the estimation of error parameters for gyroscopes and accelerometers. The predictive error minimization (PEM) stochastic modeling method is used to simultaneously model the effect of bias instability and random walk noise on the calibration Kalman filters to diminish the biased estimations. The proposed procedure is simulated numerically and has expected experimental results. The calibration maneuvers are applied using a two-axis angle turntable in a way that the persistency of excitation (PE) condition for parameter estimation is met. For this purpose, a trapezoidal calibration profile is utilized to excite different deterministic error parameters of the accelerometers and a pulse profile is used for the gyroscopes. Furthermore, to evaluate the performance of the proposed KF calibration method, a conventional least squares (LS) calibration procedure is derived for the SRIMUs and the simulation and experimental results compare the functionality of the two proposed methods with each other.
Statistics on cannabis users skew perceptions of cannabis use
Rachel Melissa Burns
2013-11-01
Full Text Available Collecting information about the prevalence of cannabis use is necessary but not sufficient for understanding the size, dynamics, and outcomes associated with cannabis markets. This paper uses two data sets describing cannabis consumption in the United States and Europe to highlight 1 differences in inferences about sub-populations based on the measure used to quantify cannabis-related activity; 2 how different measures of cannabis-related activity can be used to more accurately describe trends in cannabis usage over time; and 3 the correlation between frequency of use in the past month and average grams consumed per day. Key findings: Focusing on days of use instead of prevalence shows substantially greater increases in U.S. cannabis use in recent years; however, the recent increase is mostly among adults, not youth. Relatively more rapid growth in use days also occurred among the college-educated and Hispanic. Further, data from a survey conducted in several European countries show a strong positive correlation between frequency of use and quantity consumed per day of use, suggesting consumption is even more skewed toward the minority of heavy users than is suggested by days-of-use calculations.
On Splitting Rings for Azumaya Skew Polynomial Rings
George Szeto; Lianyong Xue
2001-01-01
Let B be a ring with 1, p an automorphism of B of order n for some integer n, and B[x; p] the skew polynomial ring in x over B such that 1, x,x2,... ,xn-1 are independent over B and xn ∈ U(Bp), where Bp is the set of elements in B fixed under p and U(Bρ) is the set of all units in Bρ. Let -ρ be the inner automorphism of B[x; p] induced by x. Assume n is a unit in B. It is shown that, for a -ρ-Galois extension B[x; p] over (B[x; ρ])-ρ (resp., a DeMeyer-Kanzaki Galois extention B over Bp), B[x; ρ] is Azumaya if and only if (B[x; ρ])-ρ (resp.,B) is Azumaya, and some splitting rings of B[x; ρ], (B[x; ρ])-ρ and B coincide.
On Approximating Frequency Moments of Data Streams with Skewed Projections
Li, Ping
2008-01-01
We propose skewed stable random projections for approximating the pth frequency moments of dynamic data streams (01) improves previous methods based on (symmetric) stable random projections. Our proposed method is applicable to data streams that are (a) insertion only (the cash-register model); or (b) always non-negative (the strict Turnstile model), or (c) eventually non-negative at check points. This is only a minor restriction for practical applications. Our method works particularly well when p = 1+/- \\Delta and \\Delta is small, which is a practically important scenario. For example, \\Delta may be the decay rate or interest rate, which are usually small. Of course, when \\Delta = 0, one can compute the 1th frequent moment (i.e., the sum) essentially error-free using a simple couter. Our method may be viewed as a ``genearlized counter'' in that it can count the total value in the future, taking in account of the effect of decaying or interest accruement. In a summary, our contributions are two-fold. (A) Thi...
Fieremans, Nathalie; Van Esch, Hilde; Holvoet, Maureen; Van Goethem, Gert; Devriendt, Koenraad; Rosello, Monica; Mayo, Sonia; Martinez, Francisco; Jhangiani, Shalini; Muzny, Donna M; Gibbs, Richard A; Lupski, James R; Vermeesch, Joris R; Marynen, Peter; Froyen, Guy
2016-08-01
Intellectual disability (ID) is a heterogeneous disorder with an unknown molecular etiology in many cases. Previously, X-linked ID (XLID) studies focused on males because of the hemizygous state of their X chromosome. Carrier females are generally unaffected because of the presence of a second normal allele, or inactivation of the mutant X chromosome in most of their cells (skewing). However, in female ID patients, we hypothesized that the presence of skewing of X-inactivation would be an indicator for an X chromosomal ID cause. We analyzed the X-inactivation patterns of 288 females with ID, and found that 22 (7.6%) had extreme skewing (>90%), which is significantly higher than observed in the general population (3.6%; P = 0.029). Whole-exome sequencing of 19 females with extreme skewing revealed causal variants in six females in the XLID genes DDX3X, NHS, WDR45, MECP2, and SMC1A. Interestingly, variants in genes escaping X-inactivation presumably cause both XLID and skewing of X-inactivation in three of these patients. Moreover, variants likely accounting for skewing only were detected in MED12, HDAC8, and TAF9B. All tested candidate causative variants were de novo events. Hence, extreme skewing is a good indicator for the presence of X-linked variants in female patients.
COMPUTATIONAL AND EXPERIMENTAL STUDY ON TIP LEAKAGE VORTEX OF CIRCUMFERENTIAL SKEWED BLADES
LI Yang; OUYANG Hua; DU Zhaohui
2007-01-01
In the steady operation condition, the experiments and the numerical simulations are used to investigate the tip leakage flow fields in three low pressure axial flow fans with three kinds of circumferential skewed rotors, including the radial rotor, the forward-skewed rotor and the backward-skewed rotor. The three-dimensional viscous flow fields of the fans are computed. In the experiments, the two-dimensional plane particle image velocimetry (PIV) system is used to measure the flow fields in the tip region of three different pitchwise positions of each fan. The results show that the computational results agree well with the experimental data in the flow field of the tip region of each fan. The tip leakage vortex core segments based on method of the eigenmode analysis can display clearly some characteristics of the tip leakage vortex, such as the origination position of tip leakage vortex, the development of vortex strength, and so on. Compared with the radial rotor, the other two skewed rotors can increase the stability of the tip leakage vortex and the increment in the forward-skewed rotor is more than that in the backward-skewed one. Among the tip leakage vortices of the three rotors, the velocity of the vortex in the forward-skewed rotor is the highest in the circumferential direction and the lowest in the axial direction.
Field, J; Solís, C R; Queller, D C; Strassmann, J E
1998-06-01
Recent models postulate that the members of a social group assess their ecological and social environments and agree a "social contract" of reproductive partitioning (skew). We tested social contracts theory by using DNA microsatellites to measure skew in 24 cofoundress associations of paper wasps, Polistes bellicosus. In contrast to theoretical predictions, there was little variation in cofoundress relatedness, and relatedness either did not predict skew or was negatively correlated with it; the dominant/subordinate size ratio, assumed to reflect relative fighting ability, did not predict skew; and high skew was associated with decreased aggression by the rank 2 subordinate toward the dominant. High skew was associated with increased group size. A difficulty with measuring skew in real systems is the frequent changes in group composition that commonly occur in social animals. In P. bellicosus, 61% of egg layers and an unknown number of non-egg layers were absent by the time nests were collected. The social contracts models provide an attractive general framework linking genetics, ecology, and behavior, but there have been few direct tests of their predictions. We question assumptions underlying the models and suggest directions for future research.
Verkuil, Yvonne I.; Juillet, Cedric; Lank, David B.; Widemo, Fredrik; Piersma, Theunis
2014-01-01
Sex differences in skews of vertebrate lifetime reproductive success are difficult to measure directly. Evolutionary histories of differential skew should be detectable in the genome. For example, male-biased skew should reduce variation in the biparentally inherited genome relative to the maternall
Purification of equine Gc-globulin
Houen, Gunnar; Pihl, Tina Holberg; Andersen, Pia Haubro
Objectives With the aim of producing antibodies for an equine Group specific component (Gc)-globulin assay, the protein was purified from normal equine plasma. Methods Equine Gc-globulin was purified from healthy horse plasma using ion exchange chromatography (Q-Sepharose, CM......-Sepharose) and preparative PAGE. Results Equine Gc-globulin has successfully been purified from healthy horse plasma and rabbits and mice are being immunized to produce specific antibodies. Conclusions Purification of equine Gc-globulin and the production of specific antibodies will make it possible to develop an assay...... to be a sensitive marker of acute tissue injury and fatal outcome in humans. Patients with a low plasma concentration of Gc-globulin due to severe tissue injury might potentially benefit from infusions with purified Gc-globulin [1]. With an equine Gc-globulin assay, future studies will investigate the concentration...
Inferences in Linear Mixed Models with Skew-normal Random Eff ects
Ren Dao YE; Tong Hui WANG
2015-01-01
For the linear mixed model with skew-normal random eff ects, this paper gives the density function, moment generating function and independence conditions. The noncentral skew chi-square distribution is defined and its density function is shown. The necessary and suﬃ cient conditions under which a quadratic form is distributed as noncentral skew chi-square distribution are obtained. Also, a version of Cochran’s theorem is given, which modifies the result of Wang et al. (2009) and is used to set up exact tests for fixed eff ects and variance components of the proposed model. For illustration, our main results are applied to a real data problem.
Shannon Entropy and Mutual Information for Multivariate Skew-Elliptical Distributions
Arellano-Valle, Reinaldo B.
2012-02-27
The entropy and mutual information index are important concepts developed by Shannon in the context of information theory. They have been widely studied in the case of the multivariate normal distribution. We first extend these tools to the full symmetric class of multivariate elliptical distributions and then to the more flexible families of multivariate skew-elliptical distributions. We study in detail the cases of the multivariate skew-normal and skew-t distributions. We implement our findings to the application of the optimal design of an ozone monitoring station network in Santiago de Chile. © 2012 Board of the Foundation of the Scandinavian Journal of Statistics.
Ding, Song; Tian, GuiYun; Dobmann, Gerd; Wang, Ping
2017-01-01
Skewness of Magnetic Barkhausen Noise (MBN) signal is used as a new feature for applied stress determination. After experimental studies, skewness presents its ability for measuring applied tensile stress compared with conventional feature, meanwhile, a non-linear behavior of this new feature and an independence of the excitation conditions under compressive stress are found and discussed. Effective damping during domain wall motion influencing the asymmetric shape of the MBN statistical distribution function is discussed under compressive and tensile stress variation. Domain wall (DW) energy and distance between pinning edges of the DW are considered altering the characteristic relaxation time, which is the reason for the non-linear phenomenon of skewness.
GPDs at non-zero skewness in ADS/QCD model
Rinaldi, Matteo
2017-08-01
We study Generalized Parton Distribution functions (GPDs) usually measured in hard exclusive processes and encoding information on the three dimensional partonic structure of hadrons and their spin decomposition, for non-zero skewness within the AdS/QCD formalism. To this aim the canonical scheme to calculate GPDs at zero skewness has been properly generalized. Furthermore, we show that the latter quantities, in this non-forward regime, are sensitive to non-trivial details of the hadronic light front wave function, such as a kind of parton correlations usually not accessible in studies of form factors and GPDs at zero skewness.
FEM-based Analysis of a Hybrid Synchronous Generator with Skewed Stator Slots
MUNTEANU, A.
2011-11-01
Full Text Available The paper presents a simulation study of a hybrid synchronous generator (dual excitation system - permanent magnets and electromagnets with skewed stator slots. The main goal is to establish if the skewing of the slots brings a significant improvement of the air-gap flux density and of the induced stator voltage. The skewness angle is the parameter in discussion. The study is based on finite element method analysis. Due to the particular geometry of the stator slots, a multilayer approach is employed.
Genetic architecture of skewed X inactivation in the laboratory mouse.
John D Calaway
Full Text Available X chromosome inactivation (XCI is the mammalian mechanism of dosage compensation that balances X-linked gene expression between the sexes. Early during female development, each cell of the embryo proper independently inactivates one of its two parental X-chromosomes. In mice, the choice of which X chromosome is inactivated is affected by the genotype of a cis-acting locus, the X-chromosome controlling element (Xce. Xce has been localized to a 1.9 Mb interval within the X-inactivation center (Xic, yet its molecular identity and mechanism of action remain unknown. We combined genotype and sequence data for mouse stocks with detailed phenotyping of ten inbred strains and with the development of a statistical model that incorporates phenotyping data from multiple sources to disentangle sources of XCI phenotypic variance in natural female populations on X inactivation. We have reduced the Xce candidate 10-fold to a 176 kb region located approximately 500 kb proximal to Xist. We propose that structural variation in this interval explains the presence of multiple functional Xce alleles in the genus Mus. We have identified a new allele, Xce(e present in Mus musculus and a possible sixth functional allele in Mus spicilegus. We have also confirmed a parent-of-origin effect on X inactivation choice and provide evidence that maternal inheritance magnifies the skewing associated with strong Xce alleles. Based on the phylogenetic analysis of 155 laboratory strains and wild mice we conclude that Xce(a is either a derived allele that arose concurrently with the domestication of fancy mice but prior the derivation of most classical inbred strains or a rare allele in the wild. Furthermore, we have found that despite the presence of multiple haplotypes in the wild Mus musculus domesticus has only one functional Xce allele, Xce(b. Lastly, we conclude that each mouse taxa examined has a different functional Xce allele.
Buch, A.; Pinnick, V. T.; Grand, N.; Szopa, C.; Danell, R.; Lustrement, B.; Freissinet, C.; van Amerom, F. H.; Raulin, F.; Glavin, D. P.; Stalport, F.; Coll, P. J.; Arevalo, R. D.; Brinckerhoff, W. B.; Goesmann, F.; Mahaffy, P. R.
2013-12-01
The joint ESA-Roscosmos Exo-Mars-2018 rover mission seeks the signs of past or present life on Mars. The Mars Organic Molecule Analyzer (MOMA) aboard the ExoMars rover will be a key analytical tool in providing chemical (molecular) information from the solid samples, with particular focus on the characterization of organic content. Central to MOMA instrumentation is a gas chromatograph-mass spectrometer (GC-MS) which provides the unique ability to characterize a broad range of compounds allowing chemical analyses of volatile and non-volatile species. The Gas chromatograph and the oven have been built at LATMOS/LISA (France) and at MPS (Germany) respectively whereas the mass spectrometer has been built at the NASA Goddard Space Flight Center (USA). Both instruments have been tested separately first and have been coupled in order to test the efficiency of the future MOMA GC-MS instrument. The main objective of the second step has been to test the quantitative response of both instruments while they are coupled and to characterize the combined instrument detection limit for several compounds. A final experiment has been done in order to test the feasibility of the separation and detection of a mixture contained in a soil sample introduced in the MOMA oven.
The generalised anxiety stigma scale (GASS: psychometric properties in a community sample
Griffiths Kathleen M
2011-11-01
Full Text Available Abstract Background Although there is substantial concern about negative attitudes to mental illness, little is known about the stigma associated with Generalised Anxiety Disorder (GAD or its measurement. The aim of this study was to develop a multi-item measure of Generalised Anxiety Disorder stigma (the GASS. Methods Stigma items were developed from a thematic analysis of web-based text about the stigma associated with GAD. Six hundred and seventeen members of the public completed a survey comprising the resulting 20 stigma items and measures designed to evaluate construct validity. Follow-up data were collected for a subset of the participants (n = 212. Results The factor structure comprised two components: Personal Stigma (views about Generalised Anxiety Disorder; and Perceived Stigma (views about the beliefs of most others in the community. There was evidence of good construct validity and reliability for each of the Generalised Anxiety Stigma Scale (GASS subscales. Conclusions The GASS is a promising brief measure of the stigma associated with Generalised Anxiety Disorder.
Liu Jin-Cun; Hou Guo-Lin
2010-01-01
In this paper, the generalised two-dimensional differential transform method (DTM) of solving the time-fractional coupled KdV equations is proposed. The fractional derivative is described in the Caputo sense. The presented method is a numerical method based on the generalised Taylor series expansion which constructs an analytical solution in the form of a polynomial. An illustrative example shows that the generalised two-dimensional DTM is effective for the coupled equations.
Generalized peak skew coefficients for Oklahoma, 1961-1990 base period.
U.S. Geological Survey, Department of the Interior — This digital-map data set consists of a grid of generalized skew coefficients of logarithms of annual maximum streamflow for Oklahoma streams less than or equal to...
The Carnot Cycle and Area-Specific Work Equivalence on a Skew T-logp Diagram
Alex DeCaria
2008-01-01
Attempts to calculate the area to specific work equivalence on a skew T-logp diagram for a Carnot cycle can lead to large errors if the pressures of the nodes of the cycle are estimated from the diagram...
The Process of price formation and the skewness of asset returns
Reimann, S
2006-01-01
Distributions of assets returns exhibit a slight skewness. In this note we show that our model of endogenous price formation \\cite{Reimann2006} creates an asymmetric return distribution if the price dynamics are a process in which consecutive trading periods are dependent from each other in the sense that opening prices equal closing prices of the former trading period. The corresponding parameter $\\alpha$ is estimated from daily prices from 01/01/1999 - 12/31/2004 for 9 large indices. For the S&P 500, the skewness distribution of all its constituting assets is also calculated. The skewness distribution due to our model is compared with the distribution of the empirical skewness values of the ingle assets.
On nomenclature for, and the relative merits of, two formulations of skew distributions
Azzalini, Adelchi
2015-12-21
We examine some skew distributions used extensively within the model-based clustering literature in recent years, paying special attention to claims that have been made about their relative efficacy. Theoretical arguments are provided as well as real data examples.
Asymptotic performance of the quadratic discriminant function to skewed training samples.
Adebanji, Atinuke; Asamoah-Boaheng, Michael; Osei-Tutu, Olivia
2016-01-01
This study investigates the asymptotic performance of the quadratic discriminant function (QDF) under skewed training samples. The main objective of this study is to evaluate the performance of the QDF under skewed distribution considering different sample size ratios, varying the group centroid separators and the number of variables. Three populations [Formula: see text] with increasing group centroid separator function were considered. A multivariate normal distributed data was simulated with MatLab R2009a. There was an increase in the average error rates of the sample size ratios 1:2:2 and 1:2:3 as the total sample size increased asymptotically in the skewed distribution when the centroid separator increased from 1 to 3. The QDF under the skewed distribution performed better for the sample size ratio 1:1:1 as compared to the other sampling ratios and under centroid separator [Formula: see text].
CONCEPTS OF DICHOTOMY FOR SKEW-EVOLUTION SEMIFLOWS IN BANACH SPACES
Mihail Megan
2011-01-01
Full Text Available In this paper we investigate some dichotomy concepts for skew-evolution semiflows in Banachspaces.Our main objective is to estab-lish relations between these concepts.We motivate our approach byillustrative examples.
LI Yang; LIU Jie; OUYANG Hua; DU Zhao-Hui
2008-01-01
This article presents the flow mechanism analysis and experimental study of a forward-skewed impeller and a radial impeller in low pressure axial fan. The forward-skewed blade was obtained by the optimization design of the radial blade and CFD technique. Measurement of the two blades was carried out in aerodynamic and aeroacoustic performance. Compared to the radial blade, the forward-skewed blade has demonstrated the improvements in efficiency, total pressure ratio, Stable Operating Range (SOR) and less aerodynamic noise. Detailed flow measurement and computation were performed for outlet flow field for investigating the responsible flow mechanisms. The results show the forward-skewed blade can cause a spanwise redistribution of flow toward the blade mid-span and reduce tip loading. This results in reduced significantly total pressure loss near hub and shroud endwall region, despite the slight increase of total pressure loss at mid-span.
Skew information in the XY model with staggered Dzyaloshinskii-Moriya interaction
Qiu, Liang, E-mail: lqiu@cumt.edu.cn [School of Physics, China University of Mining and Technology, Xuzhou, Jiangsu 221116 (China); Quan, Dongxiao [State Key Laboratory of Integrated Services Networks, Xidian University, Xi' an, Shaanxi 710071 (China); Pan, Fei; Liu, Zhi [School of Physics, China University of Mining and Technology, Xuzhou, Jiangsu 221116 (China)
2017-06-01
We study the performance of the lower bound of skew information in the vicinity of transition point for the anisotropic spin-1/2 XY chain with staggered Dzyaloshinskii-Moriya interaction by use of quantum renormalization-group method. For a fixed value of the Dzyaloshinskii-Moriya interaction, there are two saturated values for the lower bound of skew information corresponding to the spin-fluid and Néel phases, respectively. The scaling exponent of the lower bound of skew information closely relates to the correlation length of the model and the Dzyaloshinskii-Moriya interaction shifts the factorization point. Our results show that the lower bound of skew information can be a good candidate to detect the critical point of XY spin chain with staggered Dzyaloshinskii-Moriya interaction.
3D Rigid-Plastic Finite Element Analysis for Skew Rolling Process of the Stepped Part
Gang FANG; Pan ZENG
2003-01-01
Based on rigid-plastic finite element method, a skew rolling process of stepped part is simulated. Considering nodesaving and effective remeshing, the tetrahedron solid elements are used to discrete workpiece. The workpiece material adopts rigid-plastic m
Porto da Silva, Edson; Zibar, Darko
2016-01-01
Simple analytical widely linear complex-valued models for IQ-imbalance and IQ-skew effects in multicarrier transmitters are presented. To compensate for such effects, a 4×4 MIMO widely linear adaptive equalizer is proposed and experimentally validated.......Simple analytical widely linear complex-valued models for IQ-imbalance and IQ-skew effects in multicarrier transmitters are presented. To compensate for such effects, a 4×4 MIMO widely linear adaptive equalizer is proposed and experimentally validated....
Landfors, Mattias; Philip, Philge; Rydén, Patrik; Stenberg, Per
2011-01-01
Genome-wide analysis of gene expression or protein binding patterns using different array or sequencing based technologies is now routinely performed to compare different populations, such as treatment and reference groups. It is often necessary to normalize the data obtained to remove technical variation introduced in the course of conducting experimental work, but standard normalization techniques are not capable of eliminating technical bias in cases where the distribution of the truly altered variables is skewed, i.e. when a large fraction of the variables are either positively or negatively affected by the treatment. However, several experiments are likely to generate such skewed distributions, including ChIP-chip experiments for the study of chromatin, gene expression experiments for the study of apoptosis, and SNP-studies of copy number variation in normal and tumour tissues. A preliminary study using spike-in array data established that the capacity of an experiment to identify altered variables and generate unbiased estimates of the fold change decreases as the fraction of altered variables and the skewness increases. We propose the following work-flow for analyzing high-dimensional experiments with regions of altered variables: (1) Pre-process raw data using one of the standard normalization techniques. (2) Investigate if the distribution of the altered variables is skewed. (3) If the distribution is not believed to be skewed, no additional normalization is needed. Otherwise, re-normalize the data using a novel HMM-assisted normalization procedure. (4) Perform downstream analysis. Here, ChIP-chip data and simulated data were used to evaluate the performance of the work-flow. It was found that skewed distributions can be detected by using the novel DSE-test (Detection of Skewed Experiments). Furthermore, applying the HMM-assisted normalization to experiments where the distribution of the truly altered variables is skewed results in considerably higher
Mattias Landfors
Full Text Available Genome-wide analysis of gene expression or protein binding patterns using different array or sequencing based technologies is now routinely performed to compare different populations, such as treatment and reference groups. It is often necessary to normalize the data obtained to remove technical variation introduced in the course of conducting experimental work, but standard normalization techniques are not capable of eliminating technical bias in cases where the distribution of the truly altered variables is skewed, i.e. when a large fraction of the variables are either positively or negatively affected by the treatment. However, several experiments are likely to generate such skewed distributions, including ChIP-chip experiments for the study of chromatin, gene expression experiments for the study of apoptosis, and SNP-studies of copy number variation in normal and tumour tissues. A preliminary study using spike-in array data established that the capacity of an experiment to identify altered variables and generate unbiased estimates of the fold change decreases as the fraction of altered variables and the skewness increases. We propose the following work-flow for analyzing high-dimensional experiments with regions of altered variables: (1 Pre-process raw data using one of the standard normalization techniques. (2 Investigate if the distribution of the altered variables is skewed. (3 If the distribution is not believed to be skewed, no additional normalization is needed. Otherwise, re-normalize the data using a novel HMM-assisted normalization procedure. (4 Perform downstream analysis. Here, ChIP-chip data and simulated data were used to evaluate the performance of the work-flow. It was found that skewed distributions can be detected by using the novel DSE-test (Detection of Skewed Experiments. Furthermore, applying the HMM-assisted normalization to experiments where the distribution of the truly altered variables is skewed results in
Optimization Design and Experimental Study of Low-Pressure Axial Fan with Forward-Skewed Blades
2007-01-01
This paper presents an experimental study of the optimization of blade skew in low pressure axial fan. Using back propagation (BP) neural network and genetic algorithm (GA), the optimization was performed for a radial blade. An optimized blade is obtained through blade forward skew. Measurement of the two blades was carried out in aerodynamic and aeroacoustic performance. Compared to the radial blade, the optimized blade demonstrated improvements in efficiency, total pres...
Promotion of cooperation in social dilemma games via generalised indirect reciprocity
Chiong, Raymond; Kirley, Michael
2015-10-01
This paper presents a novel generalised indirect reciprocity approach for promoting cooperation in social dilemma games. Here, players decide upon an action to play in the game based on public information (or "external cues") rather than individual-specific information. The public information is constantly updated according to the underlying learning model. Comprehensive simulation experiments using the N-player Prisoner's Dilemma (PD) and Snowdrift (SD) games show that generalised indirect reciprocity promotes high levels of cooperation across a wide range of conditions. This is despite the fact that the make-up of player groups is continually changing. As expected, the extent of cooperative behaviour observed in the "constraint-relaxed" N-player SD game is significantly higher than the N-player PD game. Our proposed generalised indirect reciprocity model may shed light on the conundrum of cooperation between anonymous individuals.
Preston, Jonathan L; Maas, Edwin; Whittle, Jessica; Leece, Megan C; McCabe, Patricia
2016-01-01
Ultrasound visual feedback of the tongue is one treatment option for individuals with persisting speech sound errors. This study evaluated children's performance during acquisition and generalisation of American English rhotics using ultrasound feedback. Three children aged 10-13 with persisting speech sound errors associated with childhood apraxia of speech (CAS) were treated for 14 one-hour sessions. Two of the participants increased the accuracy of their rhotic production during practise trials within treatment sessions, but none demonstrated generalisation to untreated words. Lack of generalisation may be due to a failure to acquire the target with sufficient accuracy during treatment, or to co-existing linguistic weaknesses that are not addressed in a motor-based treatment. Results suggest a need to refine the intervention procedures for CAS and/or a need to identify appropriate candidates for intervention to optimise learning.
Mapping of quantitative trait loci using the skew-normal distribution
无
2007-01-01
In standard interval mapping (IM) of quantitative trait loci (QTL), the QTL effect is described by a normal mixture model. When this assumption of normality is violated, the most commonly adopted strategy is to use the previous model after data transformation. However, an appropriate transformation may not exist or may be difficult to find. Also this approach can raise interpretation issues. An interesting alternative is to consider a skew-normal mixture model in standard IM, and the resulting method is here denoted as skew-normal IM. This flexible model that includes the usual symmetric normal distribution as a special case is important, allowing continuous variation from normality to non-normality. In this paper we briefly introduce the main peculiarities of the skew-normal distribution. The maximum likelihood estimates of parameters of the skew-normal distribution are obtained by the expectation-maximization (EM) algorithm. The proposed model is illustrated with real data from an intercross experiment that shows a significant departure from the normality assumption. The performance of the skew-normal IM is assessed via stochastic simulation. The results indicate that the skew-normal IM has higher power for QTL detection and better precision of QTL location as compared to standard IM and nonparametric IM.
Suescun-Diaz, Daniel [Surcolombiana Univ., Neiva (Colombia). Groupo de Fisica Teorica; Narvaez-Paredes, Mauricio [Javeriana Univ., Cali (Colombia). Groupo de Matematica y Estadistica Aplicada Pontificia; Lozano-Parada, Jamie H. [Univ. del Valle, Cali (Colombia). Dept. de Ingenieria
2016-03-15
In this paper, the generalisation of the 4th-order Adams-Bashforth-Moulton predictor-corrector method is proposed to numerically solve the point kinetic equations of the nuclear reactivity calculations without using the nuclear power history. Due to the nature of the point kinetic equations, different predictor modifiers are used in order improve the precision of the approximations obtained. The results obtained with the prediction formulas and generalised corrections improve the precision when compared with previous methods and are valid for various forms of nuclear power and different time steps.
Zhen Zhen LI; Xiao Jiang GUO; Zhi Qing FU
2012-01-01
A left GC-lpp semigroup S is called split if the natural homomorphism γb of S onto S/γ induced by γ is split.It is proved that a left GC-lpp semigroup is split if and only if it has a left adequate transversal.In particular,a construction theorem for split left GC-lpp semigroups is established.
Purification of equine Gc-globulin
Houen, Gunnar; Pihl, Tina Holberg; Andersen, Pia Haubro;
Objectives With the aim of producing antibodies for an equine Group specific component (Gc)-globulin assay, the protein was purified from normal equine plasma. Methods Equine Gc-globulin was purified from healthy horse plasma using ion exchange chromatography (Q-Sepharose, CM-Sepharose) and prepa......Objectives With the aim of producing antibodies for an equine Group specific component (Gc)-globulin assay, the protein was purified from normal equine plasma. Methods Equine Gc-globulin was purified from healthy horse plasma using ion exchange chromatography (Q-Sepharose, CM......-Sepharose) and preparative PAGE. Results Equine Gc-globulin has successfully been purified from healthy horse plasma and rabbits and mice are being immunized to produce specific antibodies. Conclusions Purification of equine Gc-globulin and the production of specific antibodies will make it possible to develop an assay...... for measuring Gc-globulin in horses. Studies in rodents and humans have shown that Gc-globulin is a multifunctional acute phase plasma protein, which removes actin from the blood by binding it and facilitating its clearance from the circulation by the liver. As such, Gc-globulin prevents hyper coagulation...
Static performance investigation of a skewed-throat multiaxis thrust-vectoring nozzle concept
Wing, David J.
1994-01-01
The static performance of a jet exhaust nozzle which achieves multiaxis thrust vectoring by physically skewing the geometric throat has been characterized in the static test facility of the 16-Foot Transonic Tunnel at NASA Langley Research Center. The nozzle has an asymmetric internal geometry defined by four surfaces: a convergent-divergent upper surface with its ridge perpendicular to the nozzle centerline, a convergent-divergent lower surface with its ridge skewed relative to the nozzle centerline, an outwardly deflected sidewall, and a straight sidewall. The primary goal of the concept is to provide efficient yaw thrust vectoring by forcing the sonic plane (nozzle throat) to form at a yaw angle defined by the skewed ridge of the lower surface contour. A secondary goal is to provide multiaxis thrust vectoring by combining the skewed-throat yaw-vectoring concept with upper and lower pitch flap deflections. The geometric parameters varied in this investigation included lower surface ridge skew angle, nozzle expansion ratio (divergence angle), aspect ratio, pitch flap deflection angle, and sidewall deflection angle. Nozzle pressure ratio was varied from 2 to a high of 11.5 for some configurations. The results of the investigation indicate that efficient, substantial multiaxis thrust vectoring was achieved by the skewed-throat nozzle concept. However, certain control surface deflections destabilized the internal flow field, which resulted in substantial shifts in the position and orientation of the sonic plane and had an adverse effect on thrust-vectoring and weight flow characteristics. By increasing the expansion ratio, the location of the sonic plane was stabilized. The asymmetric design resulted in interdependent pitch and yaw thrust vectoring as well as nonzero thrust-vector angles with undeflected control surfaces. By skewing the ridges of both the upper and lower surface contours, the interdependency between pitch and yaw thrust vectoring may be eliminated
Lal, Dennis; Ruppert, Ann-Kathrin; Trucks, Holger; Schulz, Herbert; de Kovel, Carolien G.; Trenite, Dorothee Kasteleijn-Nolst; Sonsma, Anja C. M.; Koeleman, Bobby P.; Lindhout, Dick; Weber, Yvonne G.; Lerche, Holger; Kapser, Claudia; Schankin, Christoph J.; Kunz, Wolfram S.; Surges, Rainer; Elger, Christian E.; Gaus, Verena; Schmitz, Bettina; Helbig, Ingo; Muhle, Hiltrud; Stephani, Ulrich; Klein, Karl M.; Rosenow, Felix; Neubauer, Bernd A.; Reinthaler, Eva M.; Zimprich, Fritz; Feucht, Martha; Moller, Rikke S.; Hjalgrim, Helle; De Jonghe, Peter; Suls, Arvid; Lieb, Wolfgang; Franke, Andre; Strauch, Konstantin; Gieger, Christian; Schurmann, Claudia; Schminke, Ulf; Nuernberg, Peter; Sander, Thomas
2015-01-01
Genetic generalised epilepsy (GGE) is the most common form of genetic epilepsy, accounting for 20% of all epilepsies. Genomic copy number variations (CNVs) constitute important genetic risk factors of common GGE syndromes. In our present genome-wide burden analysis, large (>= 400 kb) and rare (= 200
State-of-the-art of automated generalisation in commercial software
Stoter, J.E.; Baella, B.; Blok, C.; Burghardt, D.; Duchêne, C.; Pla, M.; Regnauld, N.; Touya, G.
2010-01-01
This report presents the EuroSDR research project that studied the state-of-the-art of automated generalisation in commercial software in a collaboration between National Mapping Agencies (NMAs), research institutes and vendors. The aims of the study were to learn more about generic and specific map
Chris van Zyl
2016-03-01
Full Text Available Background: Emergency neuroimaging of human immunodeficiency virus (HIV-positive patients with generalised new onset seizures (NOS and a normal post-ictal neurological examination remains controversial, with the general impression being that emergency imaging is necessary because immunosuppression may blur clinical indicators of acute intracranial pathology. The objectives of our study were to establish whether cranial computed tomography (CT affects the emergency management of HIV-positive patients with generalised NOS and a normal post-ictal neurological examination.Method: We conducted a prospective descriptive observational study. Consecutive HIVpositive patients of 18 years and older, who presented to the Kimberley Hospital Complex’s Emergency Department within 24 hours of their first generalised seizures and who had undergone normal post-ictal neurological examinations, were included. Emergency CT results as well as CD4-count levels were evaluated.Results: A total of 25 HIV-positive patients were included in the study. The results of cranial CT brought about a change in emergency care management in 12% of patients, all of them with CD4 counts below 200 cells/mm3 .Conclusion: We suggest that emergency cranial CT be performed on all HIV-positive patients presenting with generalised NOS and a normal post-ictal neurological examination, particularly if the CD4 count is below 200 cells/mm3.Keywords: HIV; Seizures; CT Brain
Generalised Smarr Formula and the Viscosity Bound for Einstein-Maxwell-Dilaton Black Holes
Liu, Hai-Shan; Pope, C N
2015-01-01
We study the shear viscosity to entropy ratio $\\eta/S$ in the boundary field theories dual to black hole backgrounds in theories of gravity coupled to a scalar field, and generalisations including a Maxwell field and non-minimal scalar couplings. Motivated by the observation in simple examples that the saturation of the $\\eta/S\\ge 1/(4\\pi)$ bound is correlated with the existence of a generalised Smarr relation for the planar black-hole solutions, we investigate this in detail for the general black-hole solutions in these theories, focusing especially on the cases where the scalar field plays a non-trivial role and gives rise to an additional parameter in the space of solutions. We find that a generalised Smarr relation holds in all cases, and in fact it can be viewed as the bulk gravity dual of the statement of the saturation of the viscosity to entropy bound. We obtain the generalised Smarr relation, whose existence depends upon a scaling symmetry of the planar black-hole solutions, by two different but rela...
A retrospective study of carbamazepine therapy in the treatment of idiopathic generalised epilepsy
O'Connor, G
2011-05-01
Objective: The exacerbation of idiopathic generalised epilepsy (IGE) by some anti-epileptic drugs (AEDs) such as carbamazepine (CBZ) has been well documented. However, it is unclear whether IGE is always worsened by the use of CBZ, or whether some patients with IGE benefit from its use. \\r\
Multi-Trial Guruswami–Sudan Decoding for Generalised Reed–Solomon Codes
Nielsen, Johan Sebastian Rosenkilde; Zeh, Alexander
2013-01-01
An iterated refinement procedure for the Guruswami–Sudan list decoding algorithm for Generalised Reed–Solomon codes based on Alekhnovich’s module minimisation is proposed. The method is parametrisable and allows variants of the usual list decoding approach. In particular, finding the list...
Acute onset of generalised pruritus as presenting symptom of Klatskin tumour.
Tobbia, Patrick; Norris, Leslie A; Karimova, Nodira
2012-08-08
A 60-year-old Korean woman presented with generalised pruritus and abdominal pain. She was initially treated with oral antihistamine therapy, but upon progression of symptoms and jaundice involvement, she was found to have a Klatskin tumour. The patient was not a candidate for surgical resection and is currently undergoing palliative care.
A reduced-load equivalence for generalised processor sharing networks with heavy-tailed input flows
Uitert, M.J.G. van; Borst, S.C.
2000-01-01
We consider networks where traffic is served according to the Generalised Processor Sharing (GPS) principle. GPS-based scheduling algorithms are considered important for providing differentiated quality of service in integrated-services networks. We are interested in the workload of a particular flo
S.M. Bogels; N. Snieder; M. Kindt
2003-01-01
The present study investigated whether children with high symptom levels of either social phobia (SP), separation anxiety disorder (SAD), or generalised anxiety disorder (GAD) are characterised by a specific set of dysfunctional interpretations that are consistent with the cognitive model of their s
Pauli Spin Paramagnetism and Electronic Specific Heat in Generalised d-Dimensions
Muktish Acharyya
2011-01-01
The variations of pauli spin paramagnetic susceptibility and the electronic specific heat of solids, are calculated as functions of temperature following the free electron approximation, in generalised d-dimensions.The results are compared and become consistent with that obtained in three dimensions.Interestingly, the Pauli spin paramagnetic susceptibility becomes independent of temperature only in two dimensions.
Inkmann, J.
2005-01-01
The inverse probability weighted Generalised Empirical Likelihood (IPW-GEL) estimator is proposed for the estimation of the parameters of a vector of possibly non-linear unconditional moment functions in the presence of conditionally independent sample selection or attrition.The estimator is applied
Passivation controller design for turbo-generators based on generalised Hamiltonian system theory
Cao, M.; Shen, T.L.; Song, Y.H.
2002-01-01
A method of pre-feedback to formulate the generalised forced Hamiltonian system model for speed governor control systems is proposed. Furthermore, passivation controllers are designed based on the scheme of Hamiltonian structure for single machne infinite bus and multimachine power systems. In parti
Modelling Problem-Solving Situations into Number Theory Tasks: The Route towards Generalisation
Papadopoulos, Ioannis; Iatridou, Maria
2010-01-01
This paper examines the way two 10th graders cope with a non-standard generalisation problem that involves elementary concepts of number theory (more specifically linear Diophantine equations) in the geometrical context of a rectangle's area. Emphasis is given on how the students' past experience of problem solving (expressed through interplay…
Dlugosz, Stephan; Mammen, Enno; Wilke, Ralf
We consider the semiparametric generalised linear regression model which has mainstream empirical models such as the (partially) linear mean regression, logistic and multinomial regression as special cases. As an extension to related literature we allow a misclassified covariate to be interacted...
Kindt, M.; Bögels, S.M.; Morren, M.
2003-01-01
The present study examined processing bias in children suffering from anxiety disorders. Processing bias was assessed using of the emotional Stroop task in clinically referred children with separation anxiety disorder (SAD), social phobia (SP), and/or generalised anxiety disorder (GAD) and normal co
Repeating Patterns: Strategies to Assist Young Students to Generalise the Mathematical Structure
Warren, Elizabeth; Miller, Jodie; Cooper, Thomas
2012-01-01
This paper focuses on very young students' ability to engage in repeating pattern tasks and identifying strategies that assist them to ascertain the structure of the pattern. It describes results of a study which is part of the Early Years Generalising Project (EYGP) and involves Australian students in Years 1 to 4 (ages 5-10). This paper reports…
Determinism, noise, and spurious estimations in a generalised model of population growth
De Vladar, H.P.; Pen, I.R.
2007-01-01
We study a generalised model of population growth in which the state variable is population growth rate instead of population size. Stochastic parametric perturbations, modelling phenotypic variability, lead to a Langevin system with two sources of multiplicative noise. The stationary probability di
Hartley, Calum; Allen, Melissa L.
2014-01-01
We investigated whether low-functioning children with autism generalise labels from colour photographs based on sameness of shape, colour, or both. Children with autism and language-matched controls were taught novel words paired with photographs of unfamiliar objects, and then sorted pictures and objects into two buckets according to whether or…
Christiansen, Maja; Jørgensen, Charlotte S; Laursen, Inga;
2007-01-01
exchange chromatography. The separated isoforms and several commercial preparations of individual isoforms were characterized by mass spectrometry. This revealed that the major isoforms were non-glycosylated. Compared to the Gc-1f isoform the other dominating isoforms represented an Asp/Glu substitution......Gc globulin, also called vitamin D-binding protein, is a plasma protein involved in the extracellular actin-scavenger system, vitamin D transport and possibly also other biological activities. Low levels of Gc globulin have been found to correlate with multiple organ failure and non......-survival of patients with fulminant hepatic failure and trauma. Here, we characterize the dominant isoforms of plasma-derived Gc globulin from Cohn fraction IV paste with respect to amino acid sequence and posttranslational modifications. Gc globulin was purified in large scale and the isoforms separated by ion...
Purification of equine Gc-globulin
Houen, Gunnar; Pihl, Tina Holberg; Andersen, Pia Haubro;
Objectives With the aim of producing antibodies for an equine Group specific component (Gc)-globulin assay, the protein was purified from normal equine plasma. Methods Equine Gc-globulin was purified from healthy horse plasma using ion exchange chromatography (Q-Sepharose, CM...... for measuring Gc-globulin in horses. Studies in rodents and humans have shown that Gc-globulin is a multifunctional acute phase plasma protein, which removes actin from the blood by binding it and facilitating its clearance from the circulation by the liver. As such, Gc-globulin prevents hyper coagulation......-globulin infusions. Reference List 1. Vasconcellos CA and Lind SE. Coordinated inhibition of actin-induced platelet aggregation by plasma gelsolin and vitamin D-binding protein. Blood 1993;82:3648-3657....
The past, present and future of reproductive skew theory and experiments.
Nonacs, Peter; Hager, Reinmar
2011-05-01
A major evolutionary question is how reproductive sharing arises in cooperatively breeding species despite the inherent reproductive conflicts in social groups. Reproductive skew theory offers one potential solution: each group member gains or is allotted inclusive fitness equal to or exceeding their expectation from reproducing on their own. Unfortunately, a multitude of skew models with conflicting predictions has led to confusion in both testing and evaluating skew theory. The confusion arises partly because one set of models (the 'transactional' type) answer the ultimate evolutionary question of what ranges of reproductive skew can yield fitness-enhancing solutions for all group members. The second set of models ('compromise') give an evolutionarily proximate, game-theoretic evolutionarily stable state (ESS) solution that determines reproductive shares based on relative competitive abilities. However, several predictions arising from compromise models require a linear payoff to increased competition and do not hold with non-linear payoffs. Given that for most species it may be very difficult or impossible to determine the true relationship between effort devoted to competition and reproductive share gained, compromise models are much less predictive than previously appreciated. Almost all skew models make one quantitative prediction (e.g. realized skew must fall within ranges predicted by transactional models), and two qualitative predictions (e.g. variation in relatedness or competitive ability across groups affects skew). A thorough review of the data finds that these three predictions are relatively rarely supported. As a general rule, therefore, the evolution of cooperative breeding appears not to be dependent on the ability of group members to monitor relatedness or competitive ability in order to adjust their behaviour dynamically to gain reproductive share. Although reproductive skew theory fails to predict within-group dynamics consistently, it does
Denise Howel
Full Text Available BACKGROUND: Obesity is now more common in lower socioeconomic groups in developed nations, but the socio-economic patterning of obesity has changed over time. This study examines the time trends in the socioeconomic patterning of generalised and abdominal obesity and overweight in English adults. METHODS: Data were from core annual samples of the Health Survey for England 1993-2008, including 155 661 participants aged 18-75 years. The prevalence of generalised and abdominal obesity and overweight was reported as crude and age-adjusted estimates. Binomial regression was used to model measures of obesity and overweight with age, sex, survey years, and two indicators of socioeconomic position: Registrar General's Social Class (manual and non-manual occupational groups and relative length of full time education. Trends in socioeconomic patterning were assessed by formal tests for interactions between socioeconomic position measures and survey periods in these models. RESULTS: The prevalence of generalised and abdominal overweight and obesity increased consistently between 1993 and 2008. There were significant differences in the four outcomes between the two socioeconomic position (SEP groups in men and women, except for generalised and abdominal overweight with social class in men. The prevalence of obesity and overweight across the whole period was higher in subgroups with lower SEP (differences of 0.2% to 9.5%. There was no significant widening of the socioeconomic gradient of most indicators of greater body fat since the early 1990s, except for educational gradient in generalised obesity in men and women (P = 0.001. CONCLUSIONS: Substantial social class and education gradients in obesity and overweight are still present in both sexes. However, there is limited evidence that these socioeconomic inequalities have changed since 1993.
Characteristic function-based semiparametric inference for skew-symmetric models
Potgieter, Cornelis J.
2012-12-26
Skew-symmetric models offer a very flexible class of distributions for modelling data. These distributions can also be viewed as selection models for the symmetric component of the specified skew-symmetric distribution. The estimation of the location and scale parameters corresponding to the symmetric component is considered here, with the symmetric component known. Emphasis is placed on using the empirical characteristic function to estimate these parameters. This is made possible by an invariance property of the skew-symmetric family of distributions, namely that even transformations of random variables that are skew-symmetric have a distribution only depending on the symmetric density. A distance metric between the real components of the empirical and true characteristic functions is minimized to obtain the estimators. The method is semiparametric, in that the symmetric component is specified, but the skewing function is assumed unknown. Furthermore, the methodology is extended to hypothesis testing. Two tests for a hypothesis of specific parameter values are considered, as well as a test for the hypothesis that the symmetric component has a specific parametric form. A resampling algorithm is described for practical implementation of these tests. The outcomes of various numerical experiments are presented. © 2012 Board of the Foundation of the Scandinavian Journal of Statistics.
Handling Data Skew in MapReduce Cluster by Using Partition Tuning
Yufei Gao
2017-01-01
Full Text Available The healthcare industry has generated large amounts of data, and analyzing these has emerged as an important problem in recent years. The MapReduce programming model has been successfully used for big data analytics. However, data skew invariably occurs in big data analytics and seriously affects efficiency. To overcome the data skew problem in MapReduce, we have in the past proposed a data processing algorithm called Partition Tuning-based Skew Handling (PTSH. In comparison with the one-stage partitioning strategy used in the traditional MapReduce model, PTSH uses a two-stage strategy and the partition tuning method to disperse key-value pairs in virtual partitions and recombines each partition in case of data skew. The robustness and efficiency of the proposed algorithm were tested on a wide variety of simulated datasets and real healthcare datasets. The results showed that PTSH algorithm can handle data skew in MapReduce efficiently and improve the performance of MapReduce jobs in comparison with the native Hadoop, Closer, and locality-aware and fairness-aware key partitioning (LEEN. We also found that the time needed for rule extraction can be reduced significantly by adopting the PTSH algorithm, since it is more suitable for association rule mining (ARM on healthcare data.
Handling Data Skew in MapReduce Cluster by Using Partition Tuning
Zhou, Yanjie; Zhou, Bing; Shi, Lei
2017-01-01
The healthcare industry has generated large amounts of data, and analyzing these has emerged as an important problem in recent years. The MapReduce programming model has been successfully used for big data analytics. However, data skew invariably occurs in big data analytics and seriously affects efficiency. To overcome the data skew problem in MapReduce, we have in the past proposed a data processing algorithm called Partition Tuning-based Skew Handling (PTSH). In comparison with the one-stage partitioning strategy used in the traditional MapReduce model, PTSH uses a two-stage strategy and the partition tuning method to disperse key-value pairs in virtual partitions and recombines each partition in case of data skew. The robustness and efficiency of the proposed algorithm were tested on a wide variety of simulated datasets and real healthcare datasets. The results showed that PTSH algorithm can handle data skew in MapReduce efficiently and improve the performance of MapReduce jobs in comparison with the native Hadoop, Closer, and locality-aware and fairness-aware key partitioning (LEEN). We also found that the time needed for rule extraction can be reduced significantly by adopting the PTSH algorithm, since it is more suitable for association rule mining (ARM) on healthcare data.
Criticality, factorization and Wigner-Yanase skew information in quantum spin chains
Cheng, W. W.; Li, J. X.; Shan, C. J.; Gong, L. Y.; Zhao, S. M.
2015-07-01
We apply the Wigner-Yanase skew information approach to analyze criticality and factorization phenomenon in the one-dimensional anisotropy model with uniform coupling interaction and periodic-two one. Based on the exact solutions of the ground states, the Wigner-Yanase skew information between two nearest-neighbor lattices is obtained. For the uniform case, the first-order derivative of the Wigner-Yanase skew information is non-analytically around the critical point. The scaling behavior and the universality are verified numerically. In particular, such skew information can also detect the factorization transition in this model. For the periodic-two case, it is found that there exist more than one phase-transition point in some parameter region due to the competition between periodicity and anisotropy. Furthermore, two kinds of phase transitions, i.e., the Ising and anisotropy transitions, driven by external field and the anisotropy parameter , are investigated carefully by the skew information. Our results state that quantum phase transition driven by the anisotropy parameter can belong to the same universality class as the one driven by external field.
温阳俊; 朱道元
2009-01-01
一般而言,偏态的椭球等高分布是一类分布族,有相当一部分的分布都是积分形式,且此类积分不易求出,而偏态的正态、偏态的正态尺度混合、偏态的PⅦ型、偏态的PⅡ型的分布却有着很好的结构,偏态t分布属于偏态PⅦ型分布,因此,本文在偏态PⅦ型分布的基础上着重研究新的偏态t分布,给出它的背景、定义、两种随机表示及其等价性.%In general, there are a large number of skew elliptically contoured distributions with hard calculated integral forms, while skew normal, skew normal scale mixtures, skew Pearson type Ⅷ and skew Pearson type Ⅱ distributions possess good structures. Skew t distributions belong to skew Pearson type Ⅷ distributions, therefore, this paper proposes new multivariate skew t distributions based on multivariate skew Pearson type Ⅷ distributions. Backgrounds and definitions are given, two stochastic representations and their equivalence are derived.
Appuhamillage, Thilanka; Thomann, Enrique; Waymire, Edward; Wood, Brian
2010-01-01
Advective skew dispersion is a natural Markov process defined by a diffusion with drift across an interface of jump discontinuity in a piecewise constant diffusion coefficient. In the absence of drift, this process may be represented as a function of $\\alpha$-skew Brownian motion for a uniquely determined value of $\\alpha=\\alpha^*$; see Ramirez et al. (2006). In the present paper, the analysis is extended to the case of nonzero drift. A determination of the (joint) distributions of key functionals of standard skew Brownian motion together with some associated probabilistic semigroup and local time theory is given for these purposes. An application to the dispersion of a solute concentration across an interface is provided that explains certain symmetries and asymmetries in recently reported laboratory experiments conducted at Lawrence-Livermore Berkeley Labs by Berkowitz et al. (2009).
Fan, Ya-Jing; Cao, Huai-Xin; Meng, Hui-Xian; Chen, Liang
2016-12-01
The uncertainty principle in quantum mechanics is a fundamental relation with different forms, including Heisenberg's uncertainty relation and Schrödinger's uncertainty relation. In this paper, we prove a Schrödinger-type uncertainty relation in terms of generalized metric adjusted skew information and correlation measure by using operator monotone functions, which reads, U_ρ ^{(g,f)}(A)U_ρ ^{(g,f)}(B)≥ f(0)^2l/k| Corr_ρ ^{s(g,f)}(A,B)| ^2 for some operator monotone functions f and g, all n-dimensional observables A, B and a non-singular density matrix ρ . As applications, we derive some new uncertainty relations for Wigner-Yanase skew information and Wigner-Yanase-Dyson skew information.
PS-Modules over Ore Extensions and Skew Generalized Power Series Rings
Refaat M. Salem
2015-01-01
Full Text Available A right R-module MR is called a PS-module if its socle, SocMR, is projective. We investigate PS-modules over Ore extension and skew generalized power series extension. Let R be an associative ring with identity, MR a unitary right R-module, O=Rx;α,δ Ore extension, MxO a right O-module, S,≤ a strictly ordered additive monoid, ω:S→EndR a monoid homomorphism, A=RS,≤,ω the skew generalized power series ring, and BA=MS,≤RS,≤, ω the skew generalized power series module. Then, under some certain conditions, we prove the following: (1 If MR is a right PS-module, then MxO is a right PS-module. (2 If MR is a right PS-module, then BA is a right PS-module.
A Cable-Passive Damper System for Sway and Skew Motion Control of a Crane Spreader
La Duc Viet
2015-01-01
Full Text Available While the crane control problem is often approached by applying a certain active control command to some parts of the crane, this paper proposes a cable-passive damper system to reduce the vibration of a four-cable suspended crane spreader. The residual sway and skew motions of a crane spreader always produce the angle deflections between the crane cables and the crane spreader. The idea in this paper is to convert those deflections into energy dissipated by the viscous dampers, which connect the cables and the spreader. The proposed damper system is effective in reducing spreader sway and skew motions. Moreover, the optimal damping coefficient can be found analytically by minimizing the time integral of system energy. The numerical simulations show that the proposed passive system can assist the input shaping control of the trolley motion in reducing both sway and skew responses.
Skewed Normal Distribution Of Return Assets In Call European Option Pricing
Evy Sulistianingsih
2011-12-01
Full Text Available Option is one of security derivates. In financial market, option is a contract that gives a right (notthe obligation for its owner to buy or sell a particular asset for a certain price at a certain time.Option can give a guarantee for a risk that can be faced in a market.This paper studies about theuse of Skewed Normal Distribution (SN in call europeanoption pricing. The SN provides aflexible framework that captures the skewness of log return. We obtain aclosed form solution forthe european call option pricing when log return follow the SN. Then, we will compare optionprices that is obtained by the SN and the Black-Scholes model with the option prices of market.Â Keywords: skewed normaldistribution, log return, options.
Fan, Ya-Jing; Cao, Huai-Xin; Meng, Hui-Xian; Chen, Liang
2016-09-01
The uncertainty principle in quantum mechanics is a fundamental relation with different forms, including Heisenberg's uncertainty relation and Schrödinger's uncertainty relation. In this paper, we prove a Schrödinger-type uncertainty relation in terms of generalized metric adjusted skew information and correlation measure by using operator monotone functions, which reads, U_ρ ^{(g,f)}(A)U_ρ ^{(g,f)}(B)≥ f(0)^2l/k| {Corr}_ρ ^{s(g,f)}(A,B)| ^2 for some operator monotone functions f and g, all n-dimensional observables A, B and a non-singular density matrix ρ . As applications, we derive some new uncertainty relations for Wigner-Yanase skew information and Wigner-Yanase-Dyson skew information.
许正文; 吴健; 霍文平; 吴振森
2003-01-01
Electromagnetic pulsed waves can be distorted in the propagation through random media, and their energy dis tributions change along the leading and trailing edge of the waveform, which can be presented by the temporal skewness. The skewness presents asymmetry and is treated by the third-order temporal moment, in which an analytic solution for the two-frequency mutual coherence function is obtained recently. Then, transionospheric pulses are discussed in details. Both theoretical analysis and numerical computation indicate that the contri butions from scattering and dispersion of irregularities dominate over those of background, so the latter can be neglected in most cases. Also, the temporal skewness of a transionospheric pulse is negative and energy is shifted to the leading edge.
Evolution of Quantitative Traits under a Migration-Selection Balance: When Does Skew Matter?
Débarre, Florence; Yeaman, Sam; Guillaume, Frédéric
2015-10-01
Quantitative-genetic models of differentiation under migration-selection balance often rely on the assumption of normally distributed genotypic and phenotypic values. When a population is subdivided into demes with selection toward different local optima, migration between demes may result in asymmetric, or skewed, local distributions. Using a simplified two-habitat model, we derive formulas without a priori assuming a Gaussian distribution of genotypic values, and we find expressions that naturally incorporate higher moments, such as skew. These formulas yield predictions of the expected divergence under migration-selection balance that are more accurate than models assuming Gaussian distributions, which illustrates the importance of incorporating these higher moments to assess the response to selection in heterogeneous environments. We further show with simulations that traits with loci of large effect display the largest skew in their distribution at migration-selection balance.
Effect of skewing the rotor teeth on the performance of doubly salient permanent magnet motors
Sheth, N. K.; Sekharbabu, A. R. C.; Rajagopal, K. R.
2006-04-01
This paper presents the effects of skewing the rotor teeth on the performance characteristics such as flux linkage, back emf, phase inductance, and reluctance torque of an 8/6 doubly salient permanent magnet motor using a simple method, which utilizes the results obtained from the two-dimensional finite element analysis. The optimum skewing angle is obtained as 12°-15° for the least ripple torque without much reduction in the back emf. Skewing the rotor teeth of an 8/6 doubly salient permanent magnet motor by 12°-15° will reduce the total harmonic distortion of the back emf profile to 29.69% from the original value of 44.69%. The reduction in the amplitude of the back emf in this case will be 18.79% only.
Chen, George Y; Codemard, Christophe A; Lewis, Richard J; Jankowski, Lukasz; Chan, Jaclyn S; Gorman, Philip M; Zervas, Michalis N
2014-07-01
The responsivity of optical fibers to refractive index can be enhanced using high-order skew rays compared with using meridional rays. Skew rays can have a much higher number of reflections with increased interaction length along the core-cladding interface, which gives rise to stronger interactions with the external medium. Reflection/transmission-type refractometric sensors based on twin-coupled-core and multimode fibers showed one/two orders of magnitude increase in responsivity with skew ray excitation. The responsivity and sensitivity for the two types are ~2000%/RIU, ~1400%/RIU, and 4.9×10⁻⁵ RIU, 7.0×10⁻⁵ RIU, respectively.
The Curious Anomaly of Skewed Judgment Distributions and Systematic Error in the Wisdom of Crowds
Nash, Ulrik William
2014-01-01
Judgment distributions are often skewed and we know little about why. This paper explains the phenomenon of skewed judgment distributions by introducing the augmented quincunx (AQ) model of sequential and probabilistic cue categorization by neurons of judges. In the process of developing inferences...... be inferred from how skewed their judgment distributions are, and in what direction they tilt. This implies not just that judgment distributions are shaped by cues, but that judgment distributions are cues themselves for the wisdom of crowds. The AQ model also predicts that judgment variance correlates......, and implications are discussed with reference to three central ideas on collective intelligence, these being Galton's conjecture on the distribution of judgments, Muth's rational expectations hypothesis, and Page's diversity prediction theorem....
Effect of PCC Joint Skew on Reflective Cracking in HMA Overlays
Ghauch, By Ziad G
2011-01-01
Reflective cracking is a relatively premature distress that occurs in HMA materials overlaying cracked and jointed underlying pavements. The high concentration of stresses and strains in the vicinity of the discontinuity of the old pavement causes the cracks to reflect into the newly placed HMA overlay. While it is a common practice to use skewed transverse joints in rigid pavements to improve the latter's performance, the impact of such a practice on the cracking of a potential HMA overlay has not been examined so far. In this context, this study investigates the effect of using skewed transverse joints in rigid pavements on reflective cracking development in the HMA overlay. Advanced three-dimensional Finite Element models including viscoelastic material properties for the HMA overlay, 3D beam modeling of dowel bars, non-uniform tire-pavement contact stresses, friction interfaces, and infinite boundary elements were constructed for both normal and skewed transverse joints using ABAQUS v-6.11. The potential ...
Olga Julià
2010-01-01
Full Text Available We report a skew-Laplace statistical analysis of both flow cytometry scatters and cell size from microbial strains primarily grown in batch cultures, others in chemostat cultures and bacterial aquatic populations. Cytometry scatters best fit the skew-Laplace distribution while cell size as assessed by an electronic particle analyzer exhibited a moderate fitting. Unlike the cultures, the aquatic bacterial communities clearly do not fit to a skew-Laplace distribution. Due to its versatile nature, the skew-Laplace distribution approach offers an easy, efficient, and powerful tool for distribution of frequency analysis in tandem with the flow cytometric cell sorting.
Elevated mortality among birds in Chernobyl as judged from skewed age and sex ratios.
Møller, Anders Pape; Bonisoli-Alquati, Andrea; Rudolfsen, Geir; Mousseau, Timothy A
2012-01-01
Radiation has negative effects on survival of animals including humans, although the generality of this claim is poorly documented under low-dose field conditions. Because females may suffer disproportionately from the effects of radiation on survival due to differences in sex roles during reproduction, radiation-induced mortality may result in male-skewed adult sex ratios. We estimated the effects of low-dose radiation on adult survival rates in birds by determining age ratios of adults captured in mist nets during the breeding season in relation to background radiation levels around Chernobyl and in nearby uncontaminated control areas. Age ratios were skewed towards yearlings, especially in the most contaminated areas, implying that adult survival rates were reduced in contaminated areas, and that populations in such areas could only be maintained through immigration from nearby uncontaminated areas. Differential mortality in females resulted in a strongly male-skewed sex ratio in the most contaminated areas. In addition, males sang disproportionately commonly in the most contaminated areas where the sex ratio was male skewed presumably because males had difficulty finding and acquiring mates when females were rare. The results were not caused by permanent emigration by females from the most contaminated areas because none of the recaptured birds had changed breeding site, and the proportion of individuals with morphological abnormalities did not differ significantly between the sexes for areas with normal and higher levels of contamination. These findings are consistent with the hypothesis that the adult survival rate of female birds is particularly susceptible to the effects of low-dose radiation, resulting in male skewed sex ratios at high levels of radiation. Such skewed age ratios towards yearlings in contaminated areas are consistent with the hypothesis that an area exceeding 30,000 km(2) in Chernobyl's surroundings constitutes an ecological trap that
Elevated mortality among birds in Chernobyl as judged from skewed age and sex ratios.
Anders Pape Møller
Full Text Available BACKGROUND: Radiation has negative effects on survival of animals including humans, although the generality of this claim is poorly documented under low-dose field conditions. Because females may suffer disproportionately from the effects of radiation on survival due to differences in sex roles during reproduction, radiation-induced mortality may result in male-skewed adult sex ratios. METHODOLOGY/PRINCIPAL FINDING: We estimated the effects of low-dose radiation on adult survival rates in birds by determining age ratios of adults captured in mist nets during the breeding season in relation to background radiation levels around Chernobyl and in nearby uncontaminated control areas. Age ratios were skewed towards yearlings, especially in the most contaminated areas, implying that adult survival rates were reduced in contaminated areas, and that populations in such areas could only be maintained through immigration from nearby uncontaminated areas. Differential mortality in females resulted in a strongly male-skewed sex ratio in the most contaminated areas. In addition, males sang disproportionately commonly in the most contaminated areas where the sex ratio was male skewed presumably because males had difficulty finding and acquiring mates when females were rare. The results were not caused by permanent emigration by females from the most contaminated areas because none of the recaptured birds had changed breeding site, and the proportion of individuals with morphological abnormalities did not differ significantly between the sexes for areas with normal and higher levels of contamination. CONCLUSIONS/SIGNIFICANCE: These findings are consistent with the hypothesis that the adult survival rate of female birds is particularly susceptible to the effects of low-dose radiation, resulting in male skewed sex ratios at high levels of radiation. Such skewed age ratios towards yearlings in contaminated areas are consistent with the hypothesis that an area
Mean-Variance-Skewness-Entropy Measures: A Multi-Objective Approach for Portfolio Selection
Yeliz Mert Kantar
2011-01-01
Full Text Available In this study, we present a multi-objective approach based on a mean-variance-skewness-entropy portfolio selection model (MVSEM. In this approach, an entropy measure is added to the mean-variance-skewness model (MVSM to generate a well‑diversified portfolio. Through a variety of empirical data sets, we evaluate the performance of the MVSEM in terms of several portfolio performance measures. The obtained results show that the MVSEM performs well out-of sample relative to traditional portfolio selection models.
Fuzzy cross-entropy, mean, variance, skewness models for portfolio selection
Rupak Bhattacharyya
2014-01-01
Full Text Available In this paper, fuzzy stock portfolio selection models that maximize mean and skewness as well as minimize portfolio variance and cross-entropy are proposed. Because returns are typically asymmetric, in addition to typical mean and variance considerations, third order moment skewness is also considered in generating a larger payoff. Cross-entropy is used to quantify the level of discrimination in a return for a given satisfactory return value. As returns are uncertain, stock returns are considered triangular fuzzy numbers. Stock price data from the Bombay Stock Exchange are used to illustrate the effectiveness of the proposed model. The solutions are done by genetic algorithms.
Multivariate skew- t approach to the design of accumulation risk scenarios for the flooding hazard
Ghizzoni, Tatiana; Roth, Giorgio; Rudari, Roberto
2010-10-01
The multivariate version of the skew- t distribution provides a powerful analytical description of the joint behavior of multivariate processes. It enjoys valuable properties: from the aptitude to model skewed as well as leptokurtic datasets to the availability of moments and likelihood analytical expressions. Moreover, it offers a wide range of extremal dependence strength, allowing for upper and lower tail dependence. The idea underneath this work is to employ the multivariate skew- t distribution to provide an estimation of the joint probability of flood events in a multi-site multi-basin approach. This constitutes the basis for the design and evaluation of flood hazard scenarios for large areas in terms of their intensity, extension and frequency, i.e. those information required by civil protection agencies to put in action mitigation strategies and by insurance companies to price the flooding risk and to evaluate portfolios. Performances of the skew- t distribution and the corresponding t copula function, introduced to represent the state of the art for multivariate simulations, are discussed with reference to the Tanaro Basin, North-western Italy. To enhance the characteristics of the correlation structure, three nested and non-nested gauging stations are selected with contributing areas from 1500 to 8000 km 2. A dataset of 76 trivariate flood events is extracted from a mean daily discharges database available for the time period from January 1995 to December 2003. Applications include the generation of multivariate skew- t and t copula samples and models' comparison through the principle of minimum cross-entropy, here revised for the application to multivariate samples. Copula and skew- t based scenario return period estimations are provided for the November 1994 flood event, i.e. the worst on record in the 1801-2001 period. Results are encouraging: the skew- t distribution seems able to describe the joint behavior, being close to the observations. Marginal
Hiroshi Miki
2012-02-01
Full Text Available Discrete spectral transformations of skew orthogonal polynomials are presented. From these spectral transformations, it is shown that the corresponding discrete integrable systems are derived both in 1+1 dimension and in 2+1 dimension. Especially in the (2+1-dimensional case, the corresponding system can be extended to 2×2 matrix form. The factorization theorem of the Christoffel kernel for skew orthogonal polynomials in random matrix theory is presented as a by-product of these transformations.
The Use of the Skew T, Log P Diagram in Analysis and Forecasting. Revision
1990-03-01
65 O 006 6063 10 1i 0 i 6 110 I1 FA*RtNEPIT TEMPCRATUX( SCALE Figure 3. Isatherms an the Skew-T Chert. in parts of water vapor per 1000 parts of dry...2 no 1000200 .p 47, 46 46 so III U $3 04 UT so s7 U 0s s .o es so t5 10050 Figure 7. Ttcdmm Socoles an Owe Skew-T Churt. * 2-7 0* ~ ~ ~ ~~~V orj or
Rhiel, G Steven
2010-02-01
In 2007, Rhiel presented a technique to estimate the coefficient of variation from the range when sampling from skewed distributions. To provide an unbiased estimate, a correction factor (a(n)) for the mean was included. Numerical correction factors for a number of skewed distributions were provided. In a follow-up paper, he provided a proof he claimed showed the correction factor was independent of the mean and standard deviation, making the factors useful as these parameters vary; however, that proof did not establish independence. Herein is a proof which establishes the independence.
Immunotherapy for Prostate Cancer with Gc Protein-Derived Macrophage-Activating Factor, GcMAF.
Yamamoto, Nobuto; Suyama, Hirofumi; Yamamoto, Nobuyuki
2008-07-01
Serum Gc protein (known as vitamin D(3)-binding protein) is the precursor for the principal macrophage-activating factor (MAF). The MAF precursor activity of serum Gc protein of prostate cancer patients was lost or reduced because Gc protein was deglycosylated by serum alpha-N-acetylgalactosaminidase (Nagalase) secreted from cancerous cells. Therefore, macrophages of prostate cancer patients having deglycosylated Gc protein cannot be activated, leading to immunosuppression. Stepwise treatment of purified Gc protein with immobilized beta-galactosidase and sialidase generated the most potent MAF (termed GcMAF) ever discovered, which produces no adverse effect in humans. Macrophages activated by GcMAF develop a considerable variation of receptors that recognize the abnormality in malignant cell surface and are highly tumoricidal. Sixteen nonanemic prostate cancer patients received weekly administration of 100 ng of GcMAF. As the MAF precursor activity increased, their serum Nagalase activity decreased. Because serum Nagalase activity is proportional to tumor burden, the entire time course analysis for GcMAF therapy was monitored by measuring the serum Nagalase activity. After 14 to 25 weekly administrations of GcMAF (100 ng/week), all 16 patients had very low serum Nagalase levels equivalent to those of healthy control values, indicating that these patients are tumor-free. No recurrence occurred for 7 years.
Large-scale genomic 2D visualization reveals extensive CG-AT skew correlation in bird genomes
Deng Xuemei
2007-11-01
Full Text Available Abstract Background Bird genomes have very different compositional structure compared with other warm-blooded animals. The variation in the base skew rules in the vertebrate genomes remains puzzling, but it must relate somehow to large-scale genome evolution. Current research is inclined to relate base skew with mutations and their fixation. Here we wish to explore base skew correlations in bird genomes, to develop methods for displaying and quantifying such correlations at different scales, and to discuss possible explanations for the peculiarities of the bird genomes in skew correlation. Results We have developed a method called Base Skew Double Triangle (BSDT for exhibiting the genome-scale change of AT/CG skew as a two-dimensional square picture, showing base skews at many scales simultaneously in a single image. By this method we found that most chicken chromosomes have high AT/CG skew correlation (symmetry in 2D picture, except for some microchromosomes. No other organisms studied (18 species show such high skew correlations. This visualized high correlation was validated by three kinds of quantitative calculations with overlapping and non-overlapping windows, all indicating that chicken and birds in general have a special genome structure. Similar features were also found in some of the mammal genomes, but clearly much weaker than in chickens. We presume that the skew correlation feature evolved near the time that birds separated from other vertebrate lineages. When we eliminated the repeat sequences from the genomes, the AT and CG skews correlation increased for some mammal genomes, but were still clearly lower than in chickens. Conclusion Our results suggest that BSDT is an expressive visualization method for AT and CG skew and enabled the discovery of the very high skew correlation in bird genomes; this peculiarity is worth further study. Computational analysis indicated that this correlation might be a compositional characteristic
The GC-heterogeneity of teleost fishes
Gautier Christian
2008-12-01
Full Text Available Abstract Background One of the most striking features of mammalian and birds chromosomes is the variation in the guanine-cytosine (GC content that occurs over scales of hundreds of kilobases to megabases; this is known as the "isochore" structure. Among other vertebrates the presence of isochores depends upon the taxon; isochore are clearly present in Crocodiles and turtles but fish genome seems very homogeneous on GC content. This has suggested a unique isochore origin after the divergence between Sarcopterygii and Actinopterygii, but before that between Sauropsida and mammals. However during more than 30 years of analysis, isochore characteristics have been studied and many important biological properties have been associated with the isochore structure of human genomes. For instance, the genes are more compact and their density is highest in GC rich isochores. Results This paper shows in teleost fish genomes the existence of "GC segmentation" sharing some of the characteristics of isochores although teleost fish genomes presenting a particular homogeneity in CG content. The entire genomes of T nigroviridis and D rerio are now available, and this has made it possible to check whether a mosaic structure associated with isochore properties can be found in these fishes. In this study, hidden Markov models were trained on fish genes (T nigroviridis and D rerio which were classified by using the isochore class of their human orthologous. A clear segmentation of these genomes was detected. Conclusion The GC content is an excellent indicator of isochores in heterogeneous genomes as mammals. The segmentation we obtained were well correlated with GC content and other properties associated to GC content such as gene density, the number of exons per gene and the length of introns. Therefore, the GC content is the main property that allows the detection of isochore but more biological properties have to be taken into account. This method allows detecting
Generalised root identities for zeta functions of curves over finite fields
Stone, Richard
2012-01-01
We consider generalised root identities for zeta functions of curves over finite fields, \\zeta_{k}, and compare with the corresponding analysis for the Riemann zeta function. We verify numerically that, as for \\zeta, the \\zeta_{k} do satisfy the generalised root identities and we investigate these in detail for the special cases of \\mu=0,-1\\:\\&\\:-2. Unlike for \\zeta, however, we show that in the setting of zeta functions of curves over finite fields the \\mu=-2 root identity is consistent with the Riemann hypothesis (RH) proved by Weil. Comparison of this analysis with the corresponding calculations for \\zeta illuminates the fact that, even though both \\zeta and \\zeta_{k} have both Euler and Hadamard product representations, it is the detailed structure of the counting function, N(T), which drives the Cesaro computations on the root side of these identities and thereby determines the implications of the root identities for RH in each setting.
A Note on the Properties of Generalised Separable Spatial Autoregressive Process
Mahendran Shitan
2009-01-01
Full Text Available Spatial modelling has its applications in many fields like geology, agriculture, meteorology, geography, and so forth. In time series a class of models known as Generalised Autoregressive (GAR has been introduced by Peiris (2003 that includes an index parameter δ. It has been shown that the inclusion of this additional parameter aids in modelling and forecasting many real data sets. This paper studies the properties of a new class of spatial autoregressive process of order 1 with an index. We will call this a Generalised Separable Spatial Autoregressive (GENSSAR Model. The spectral density function (SDF, the autocovariance function (ACVF, and the autocorrelation function (ACF are derived. The theoretical ACF and SDF plots are presented as three-dimensional figures.
Mixing angle and phase correlations from A5 with generalised CP and their prospects for discovery
Ballett, Peter; Turner, Jessica
2015-01-01
The observed leptonic mixing pattern could be explained by the presence of a discrete flavour symmetry broken into residual subgroups at low energies. In this scenario, a residual generalised CP symmetry allows the parameters of the PMNS matrix, including Majorana phases, to be predicted in terms of a small set of input parameters. In this article, we study the mixing parameter correlations arising from the symmetry group A5 including generalised CP subsequently broken into all of its possible residual symmetries. Focusing on those patterns which satisfy present experimental bounds, we then provide a detailed analysis of the measurable signatures accessible to the planned reactor, superbeam and neutrinoless double beta decay experiments. We also discuss the role which could be played by high-precision measurements from longer term projects such as the Neutrino Factory. This work provides a concrete example of how the synergies of the upcoming experimental programme allow flavour symmetric models to be thoroug...
Does our research tool kit equip us to make generalisable claims about dental education?
Chambers, D W
2012-11-01
In this essay on the state of scholarship in dental education, I argue that we are best served by looking at the validity, generalisability and usefulness of claims rather than at the rigour of various research methods. All papers published in 2009 in the European Journal of Dental Education (a quarterly) and the Journal of Dental Education (published monthly), a quarterly journal of the Academy of Management, Learning & Education and the monthly American Journal of Orthodontics and Dentofacial Orthopedics were classified by the type of claim made, method by which evidence was collected and techniques of analysis. The dental education literature, compared with the two other journals, was largely focussed on surveys of opinion or particular practices and lacked scope in generalisability. The dental education literature was thin in use of randomisation, covariable analysis and theory-building.
Generalisation benefits of output gating in a model of prefrontal cortex
Kriete, Trent; Noelle, David C.
2011-06-01
The prefrontal cortex (PFC) plays a central role in flexible cognitive control, including the suppression of habitual responding in favour of situation-appropriate behaviours that can be quite novel. PFC provides a kind of working memory, maintaining the rules, goals, and/or actions that are to control behaviour in the current context. For flexible control, these PFC representations must be sufficiently componential to support systematic generalisation to novel situations. The anatomical structure of PFC can be seen as implementing a componential 'slot-filler' structure, with different components encoded over isolated pools of neurons. Previous PFC models have highlighted the importance of a dynamic gating mechanism to selectively update individual 'slot' contents. In this article, we present simulation results that suggest that systematic generalisation also requires an 'output gating' mechanism that limits the influence of PFC on more posterior brain areas to reflect a small number of representational components at any one time.
Damgård, Ivan Bjerre; Jurik, Mads Johan
2001-01-01
to t out of L candidates. The same basic building blocks can also be adapted to provide receipt-free elections, under appropriate physical assumptions. The scheme for 1 out of L elections can be optimised such that for a certain range of parameter values, a ballot has size only O(log L) bits.......We propose a generalisation of Paillier's probabilistic public key system, in which the expansion factor is reduced and which allows to adjust the block length of the scheme even after the public key has been fixed, without loosing the homomorphic property. We show that the generalisation...... blocks can be used for applying the scheme to efficient electronic voting. This reduces dramatically the work needed to compute the final result of an election, compared to the previously best known schemes. We show how the basic scheme for a yes/no vote can be easily adapted to casting a vote for up...
Generalised Thermo-Elasticity When the Material Coupling Parameter Equals Unity
D. Rama Murthy
1979-04-01
Full Text Available Analytical solutions of three problems using the theory of generalised thermo-elasticity are presented for the case when the material coupling parameter equals unity (lambda =1. The problems considered are (1 Constant velocity impact, (2 Daniloviskaya's problem, and (3 Step in strain. Solutions are presented for the case of thin bars (one dimensional stress and are obtained using Laplace transform. There is a great simplification in the equations of generalised thermo-elasticity when the material coupling parameter equals unity, which permits the straight forward inversion of the transformed solutions. The solutions obtained are more general which includes the effect of relaxation time also. The important feature of this paper is that the solutions of coupled theory can be readily obtained simply by putting the relaxation constant equals to zero (Beta=0.
Modulation techniques and applications in comprehensive two-dimensional gas chromatography (GC x GC)
Pursch, Matthias [Dow Deutschland GmbH and Co. OHG, Analytical Sciences, 77836 Rheinmuenster (Germany); Sun, Kefu; Winniford, Bill; Weber, Andy [Dow Chemical Company, Analytical Sciences, Freeport, TX 77541 (United States); Cortes, Hernan; McCabe, Terry [Dow Chemical Company, Analytical Sciences, Midland MI 48667 (United States); Luong, Jim [Dow Canada, Analytical Sciences, Fort Saskatchewan (Canada)
2002-07-01
More than a decade after Phillips' first published work this article reviews recent developments in comprehensive two-dimensional gas chromatography (GC x GC). Special attention is devoted to the further development and diversity of modulation devices. These include heated sweepers, cryofocused modulators, and a variety of diaphragm valve-switching strategies. It is demonstrated that all modulation approaches can be very well suited to GC x GC, depending on the particular application. Diaphragm-valve modulation is very powerful for volatile organic compounds. Slotted heater and cryofocused modulation are preferred for samples that contain non-volatile components. Applications ranging from petroleum to environmental and biological samples are illustrated. Extension of the technique to GC x GC-mass spectrometry (MS) is also discussed and trends for future research activity are pointed out. (orig.)
Melnikov, Yuri B.
2016-09-01
Quadratic form approach allows for new results in the analysis of a class of integral-difference operators in finite domains: non-negativity, spectral estimations, a new property of Legendre polynomials, and establishing links with weighted mean-square deviation functionals and with infinite Jacobi matrices with not-bounded coefficients. Generalisation of integral-difference operators to higher dimensions is provided and application to matter relaxation in a field is considered. A new class of special functions naturally appears.
Generalised Israel Junction Conditions for a Gauss-Bonnet Brane World
Davis, S C
2003-01-01
In spacetimes of dimension greater than four it is natural to consider higher order (in R) corrections to the Einstein equations. In this letter generalized Israel junction conditions for a membrane in such a theory are derived. This is achieved by generalising the Gibbons-Hawking boundary term. The junction conditions are applied to simple brane world models, and are compared to the many contradictory results in the literature.
2015-01-01
Aims: The aim of this study was to investigate the prevalence of musculoskeletal pain and generalised joint hypermobility (GJH) among professional jazz musicians in Swedish big bands and to investigate possible associations between GJH and pain.Methods: An existing health questionnaire developed for professional orchestra musicians, including the 5-part questionnaire for GJH [1], the standardised Nordic questionnaire for musculoskeletal pain disorders [2] and additional specific questions abo...
Aspects of string theory compactifications. D-brane statistics and generalised geometry
Gmeiner, F.
2006-05-26
In this thesis we investigate two different aspects of string theory compactifications. The first part deals with the issue of the huge amount of possible string vacua, known as the landscape. Concretely we investigate a specific well defined subset of type II orientifold compactifications. We develop the necessary tools to construct a very large set of consistent models and investigate their gauge sector on a statistical basis. In particular we analyse the frequency distributions of gauge groups and the possible amount of chiral matter for compactifications to six and four dimensions. In the phenomenologically relevant case of four-dimensional compactifications, special attention is paid to solutions with gauge groups that include those of the standard model, as well as Pati-Salam, SU(5) and flipped SU(5) models. Additionally we investigate the frequency distribution of coupling constants and correlations between the observables in the gauge sector. These results are compared with a recent study of Gepner models. Moreover, we elaborate on questions concerning the finiteness of the number of solutions and the computational complexity of the algorithm. In the second part of this thesis we consider a new mathematical framework, called generalised geometry, to describe the six-manifolds used in string theory compactifications. In particular, the formulation of T-duality and mirror symmetry for nonlinear topological sigma models is investigated. Therefore we provide a reformulation and extension of the known topological A- and B-models to the generalised framework. The action of mirror symmetry on topological D-branes in this setup is presented and the transformation of the boundary conditions is analysed. To extend the considerations to D-branes in type II string theory, we introduce the notion of generalised calibrations. We show that the known calibration conditions of supersymmetric branes in type IIA and IIB can be obtained as special cases. Finally we investigate
A reduced-load equivalence for generalised processor sharing networks with heavy-tailed input flows
2000-01-01
We consider networks where traffic is served according to the Generalised Processor Sharing (GPS) principle. GPS-based scheduling algorithms are considered important for providing differentiated quality of service in integrated-services networks. We are interested in the workload of a particular flow~$i$ at the bottleneck node on its path. Flow $i$ is assumed to have long-tailed traffic characteristics. We distinguish between two traffic scenarios, (i) flow~$i$ generates instantaneous traffic...
2005-01-01
The inverse probability weighted Generalised Empirical Likelihood (IPW-GEL) estimator is proposed for the estimation of the parameters of a vector of possibly non-linear unconditional moment functions in the presence of conditionally independent sample selection or attrition.The estimator is applied to the estimation of the firm size elasticity of product and process R&D expenditures using a panel of German manufacturing firms, which is affected by attrition and selection into R&D activities....
Adoption of generalised audit software (GAS) by external auditors in the UK
Ahmi, Aidi
2012-01-01
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University. This research is motivated by the interest in understanding the usage of the Generalised Audit Software (GAS) by external auditors within public accounting firms. GAS is a tool used by auditors to automate various audit tasks. It helps auditors to analyse accounting data electronically where it is quite impossible to do so manually. GAS is claimed to be the most influential Computer Assisted ...
A study of the one dimensional total generalised variation regularisation problem
Papafitsoros, Konstantinos
2015-03-01
© 2015 American Institute of Mathematical Sciences. In this paper we study the one dimensional second order total generalised variation regularisation (TGV) problem with L2 data fitting term. We examine the properties of this model and we calculate exact solutions using simple piecewise affine functions as data terms. We investigate how these solutions behave with respect to the TGV parameters and we verify our results using numerical experiments.
Quantifying cooperativity in water clusters: an attempt towards obtaining a generalised equation
Saha, Soumen; Narahari Sastry, G.
2015-10-01
The current study describes the development of a general equation of cooperativity energy (CE) for an n-mer system based on the difference between interaction energy of the system and the sum of interaction energy of its dimeric subunits. The counterpoise corrected generalised CE equation of n-mer system has also been developed. In order to validate these two generalised equations, we have considered four different kinds of water clusters, viz. W1D, W2D, W2D-H and W3D, ((H2O)n: n = 3-10), with the increasing cluster size as well as changing arrangements. The CE obtained from the two generalised equations follow the trend W3D > W2D-H > W2D > W1D. The deviation at n = 6 for W3D clusters in the plot of CE with cluster size has also been observed for O-H stretching frequencies, electron density and the Laplacian of the electron density plots. The contrastingly higher CE for cyclic pentamer compared to hexamer is in accordance with earlier observations as well as computed average hydrogen bond lengths. We have observed that the average charge value is more on oxygen atoms of pentamer than hexamer resulting in the shortening of hydrogen bond in pentamer and hence the CE values are more for pentamer than hexamer. We have shown that CE has the capability to quantify the cooperativity effect in water clusters.
Kim, Se Hee; Lee, Jeong Ho; Ryu, Hye Won; Lim, Byung Chan; Chae, Jong Hee; Choi, Ji Eun; Hwang, Yong Seoung; Kim, Ki Joong
2013-03-01
We evaluated the efficacy and tolerability of rufinamide adjunctive therapy in children with refractory generalised epilepsy. The study cohort consisted of 20 patients with Lennox-Gastaut syndrome, 5 with Dravet syndrome, and 28 with unclassified refractory generalised epilepsy. Patients with more than 50% seizure reduction at three and six months were defined as responders. The overall response rate was 37.7% at three months and 34.0% at six months. At three months, patients with Lennox-Gastaut syndrome (40.0%) and epilepsy with spasms/tonic seizures (38.5%) showed higher response rates than those with Dravet syndrome (20.0%) and epilepsy with myoclonic seizures (20.0%). High response rates in patients with Lennox-Gastaut syndrome (30.0%) and epilepsy with spasms/tonic seizures (38.5%) were sustained throughout the six-month study. The accuracy of, and differences between, responder rates should, however, be interpreted with caution due to the small number of patients. Overall, rufinamide appeared to be effective and reasonably well tolerated in this group of children with refractory generalised epilepsies, although a subgroup of patients with Dravet syndrome and epilepsy with myoclonic seizures were less responsive to rufinamide treatment.
Bojesen, A; Hertz, J M; Gravholt, C H
2011-01-01
The phenotypic variation of Klinefelter syndrome (KS) is wide and may by caused by various genetic and epigenetic effects. Skewed inactivation of the supra-numerical X chromosome and polymorphism in the androgen receptor (AR) have been suggested as plausible causes. We wanted to describe X...
The curious anomaly of skewed judgment distributions and systematic error in the wisdom of crowds.
Ulrik W Nash
Full Text Available Judgment distributions are often skewed and we know little about why. This paper explains the phenomenon of skewed judgment distributions by introducing the augmented quincunx (AQ model of sequential and probabilistic cue categorization by neurons of judges. In the process of developing inferences about true values, when neurons categorize cues better than chance, and when the particular true value is extreme compared to what is typical and anchored upon, then populations of judges form skewed judgment distributions with high probability. Moreover, the collective error made by these people can be inferred from how skewed their judgment distributions are, and in what direction they tilt. This implies not just that judgment distributions are shaped by cues, but that judgment distributions are cues themselves for the wisdom of crowds. The AQ model also predicts that judgment variance correlates positively with collective error, thereby challenging what is commonly believed about how diversity and collective intelligence relate. Data from 3053 judgment surveys about US macroeconomic variables obtained from the Federal Reserve Bank of Philadelphia and the Wall Street Journal provide strong support, and implications are discussed with reference to three central ideas on collective intelligence, these being Galton's conjecture on the distribution of judgments, Muth's rational expectations hypothesis, and Page's diversity prediction theorem.
Influence of Slope and Slenderness Ratio on the Non-Column Volume in Skew Rolling
Yongqiang KANG; Zhenghuan HU; Jinping LIU; Cuiping YANG; Huiping DU
2003-01-01
A definition of non-column volume ratio (NCVR) is brought forward by the authors. It is influenced greatly by the slendernessratio of the cylindrical billet and the slope of the wedge on the tool of skew rolling. Using the numerical simulation, the lawof
Finite Element Studies on Free Vibration of Laminated Composite Cylindrical Skew Panels
Srinivasa Chikkol Venkateshappa
2014-01-01
Full Text Available This paper presents the finite element studies made on free vibration of isotropic and laminated composite cylindrical skew panels. A finite element analysis is performed using CQUAD4 and CQUAD8 elements of MSC/NASTRAN software. The effects of the panel angle, skew angle, aspect ratio, and length-to-thickness-ratio on fundamental natural frequency of vibration of isotropic cylindrical skew panels are studied. The effects of additional parameters such as fiber orientation angle, numbers of layers (keeping total thickness constant, and laminate stacking sequence on the fundamental frequency of vibration of antisymmetric composite laminates have also been studied. During validation and convergence study, it is found that the CQUAD8 element yields more accurate results than the CQUAD4 element. Hence the CQUAD8 element has been employed for the remaining part of the investigation. The fundamental frequency is found to increase with the panel angle and skew angle. The variation of the fundamental frequency with the number of layers is not appreciable when the number of layers is greater than about 6. It is also seen that the boundary conditions have significant influence on the fundamental frequency.
Development of a Skewed Pipe Shear Connector for Precast Concrete Structures.
Kim, Sang-Hyo; Choi, Jae-Gu; Park, Sejun; Lee, Hyunmin; Heo, And Won-Ho
2017-05-13
Joint connection methods, such as shear key and loop bar, improve the structural performance of precast concrete structures; consequently, there is usually decreased workability or constructional efficiency. This paper proposes a high-efficiency skewed pipe shear connector. To resist shear and pull-out forces, the proposed connectors are placed diagonally between precast concrete segments and a cast-in-place concrete joint part on a girder. Design variables (such as the pipe diameter, length, and insertion angle) have been examined to investigate the connection performance of the proposed connector. The results of our testing indicate that the skewed pipe shear connectors have 50% higher ductility and a 15% higher ratio of maximum load to yield strength as compared to the corresponding parameters of the loop bar. Finite element analysis was used for validation. The resulting validation indicates that, compared to the loop bar, the skewed pipe shear connector has a higher ultimate shear and pull-out resistance. These results indicate that the skewed pipe shear connector demonstrates more idealized behavior than the loop bar in precast concrete structures.
Robust Runtime Optimization and Skew-Resistant Execution of Analytical SPARQL Queries on Pig
Kotoulas, S; Urbani, J.; Boncz, P.A.; Mika, P.
2012-01-01
We describe a system that incrementally translates SPARQL queries to Pig Latin and executes them on a Hadoop cluster. This system is designed to work eciently on complex queries with many self-joins over huge datasets, avoiding job failures even in the case of joins with unexpected high-value skew.
Consistent paternity skew through ontogeny in Peron's tree frog (Litoria peronii.
Craig D H Sherman
Full Text Available BACKGROUND: A large number of studies in postcopulatory sexual selection use paternity success as a proxy for fertilization success. However, selective mortality during embryonic development can lead to skews in paternity in situations of polyandry and sperm competition. Thus, when assessment of paternity fails to incorporate mortality skews during early ontogeny, this may interfere with correct interpretation of results and subsequent evolutionary inference. In a previous series of in vitro sperm competition experiments with amphibians (Litoria peronii, we showed skewed paternity patterns towards males more genetically similar to the female. METHODOLOGY/PRINCIPAL FINDINGS: Here we use in vitro fertilizations and sperm competition trials to test if this pattern of paternity of fully developed tadpoles reflects patterns of paternity at fertilization and if paternity skews changes during embryonic development. We show that there is no selective mortality through ontogeny and that patterns of paternity of hatched tadpoles reflects success of competing males in sperm competition at fertilization. CONCLUSIONS/SIGNIFICANCE: While this study shows that previous inferences of fertilization success from paternity data are valid for this species, rigorous testing of these assumptions is required to ensure that differential embryonic mortality does not confound estimations of true fertilization success.
Influence of pressure gradient on streamwise skewness factor in turbulent boundary layer
Dróżdż, Artur
2014-08-01
The paper shows an effect of favourable and adverse pressure gradients on turbulent boundary layer. The skewness factor of streamwise velocity component was chosen as a measure of the pressure gradient impact. It appears that skewness factor is an indicator of convection velocity of coherent structures, which is not always equal to the average flow velocity. The analysis has been performed based upon velocity profiles measured with hot-wire technique in turbulent boundary layer with pressure gradient corresponding to turbomachinery conditions. The results show that the skewness factor decreases in the flow region subjected to FPG and increases in the APG conditions. The changes of convection velocity and skewness factor are caused by influence of large-scale motion through the mechanism called amplitude modulation. The large-scale motion is less active in FPG and more active in APG, therefore in FPG the production of vortices is random (there are no high and low speed regions), while in the APG the large-scale motion drives the production of vortices. Namely, the vortices appear only in the high-speed regions, therefore have convection velocity higher than local mean velocity. The convection velocity affects directly the turbulent sweep and ejection events. The more flow is dominated by large-scale motion the higher values takes both the convection velocity of small-scale structures and sweep events induced by them.
Large-scale age-dependent skewed sex ratio in a sexually dimorphic avian scavenger.
Sergio A Lambertucci
Full Text Available Age-dependent skewed sex ratios have been observed in bird populations, with adult males generally outnumbering females. This trend is mainly driven by higher female mortality, sometimes associated with anthropogenic factors. Despite the large amount of work on bird sex ratios, research examining the spatial stability of adult sex ratios is extremely scarce. The Andean condor (Vultur gryphus is the only bird of prey with strong sexual dimorphism favouring males (males are 30% heavier than females. By examining data from most of its South-American range, we show that while the juvenile sex ratio is balanced, or even female-skewed, the sex ratio becomes increasing male-skewed with age, with adult males outnumbering females by >20%, and, in some cases by four times more. This result is consistent across regions and independent of the nature of field data. Reasons for this are unknown but it can be hypothesized that the progressive disappearance of females may be associated with mortality caused by anthropogenic factors. This idea is supported by the asymmetric habitat use by the two sexes, with females scavenging in more humanized areas. Whatever the cause, male-skewed adult sex ratios imply that populations of this endangered scavenger face higher risks of extinction than previously believed.
Large-scale age-dependent skewed sex ratio in a sexually dimorphic avian scavenger.
Lambertucci, Sergio A; Carrete, Martina; Donázar, José Antonio; Hiraldo, Fernando
2012-01-01
Age-dependent skewed sex ratios have been observed in bird populations, with adult males generally outnumbering females. This trend is mainly driven by higher female mortality, sometimes associated with anthropogenic factors. Despite the large amount of work on bird sex ratios, research examining the spatial stability of adult sex ratios is extremely scarce. The Andean condor (Vultur gryphus) is the only bird of prey with strong sexual dimorphism favouring males (males are 30% heavier than females). By examining data from most of its South-American range, we show that while the juvenile sex ratio is balanced, or even female-skewed, the sex ratio becomes increasing male-skewed with age, with adult males outnumbering females by >20%, and, in some cases by four times more. This result is consistent across regions and independent of the nature of field data. Reasons for this are unknown but it can be hypothesized that the progressive disappearance of females may be associated with mortality caused by anthropogenic factors. This idea is supported by the asymmetric habitat use by the two sexes, with females scavenging in more humanized areas. Whatever the cause, male-skewed adult sex ratios imply that populations of this endangered scavenger face higher risks of extinction than previously believed.
Skewness and Kurtosis as Applied to a Portfolio in the Korean Stock Market
Ahn, Tae-Sung
2009-04-01
A well diversified portfolio is critical to prudent investment in a stock market. To lessen risk in a volatile market, portfolios should minimize dispersion. This paper analyzes skewness and kurtosis of businesses listed on Korean stock markets, e.g., KOSPI and KOSDAQ. It looks at distribution using the Gauss function, and examines how mean and variance can be applied in building a portfolio.
Bourke, A F; Green, H A; Bruford, M W
1997-02-22
We investigated the fine genetic structure of colonies of the ant, Leptothorax acervorum, to examine how queens share parentage (skew) in a social insect with multiple queens (polygyny). Overall, 494 individuals from eight polygynous field colonies were typed at up to seven microsatellite loci each. The first main finding was that surprisingly many sexual progeny (60% of young queens and 49% of young males) were not the offspring of the extant queens within their colonies. This implies that a high turnover (brief reproductive lifespan) of queens within colonies could be an important feature of polygyny. The second main result was that in most colonies relatedness among sexual progeny fell significantly below that expected among full siblings, proving that these progeny were produced by more than one singly-mated queen, but that skew in two colonies where the data permitted its calculation was moderate to high. However, relative to a German population, the study population is characterized by low queen-queen relatedness and low skew in female production, which is in line with the predictions of skew theory.
Generalized Christoffel-Darboux formula for skew-orthogonal polynomials and random matrix theory
Ghosh, Saugata [Abdus Salam ICTP, Strada Costiera 11, 34100, Trieste (Italy)
2006-07-14
We obtain a generalized Christoffel-Darboux (GCD) formula for skew-orthogonal polynomials. Using this, we present an alternative derivation of the level density and two-point function for Gaussian orthogonal ensembles and Gaussian symplectic ensembles of random matrices.
Subordinate wasps are more aggressive in colonies with low reproductive skew
Fanelli, D.; Boomsma, Jacobus Jan; Turillazzi, S.
2008-01-01
The small societies of primitively eusocial wasps have provided interesting testing grounds for reproductive skew theory because all individuals have similar reproductive potential, which is unusual in social insects but common in vertebrate societies. Aggression is a key parameter in testing the...
Dirac structures and boundary control systems associated with skew-symmetric differential operators
Le Gorrec, Y.; Zwart, H.J.; Maschke, B.
2005-01-01
Associated with a skew-symmetric linear operator on the spatial domain $[a,b]$ we define a Dirac structure which includes the port variables on the boundary of this spatial domain. This Dirac structure is a subspace of a Hilbert space. Naturally, associated with this Dirac structure is an infinite-d
Dirac structures and boundary control systems associated with skew-symmetric differential operators
Le Gorrec, Y.; Zwart, H.J.; Maschke, B.
2004-01-01
Associated with a skew-symmetric linear operator on the spatial domain $[a,b]$ we define a Dirac structure which includes the port variables on the boundary of this spatial domain. This Dirac structure is a subspace of a Hilbert space. Naturally, associated to this Dirac structure is infinite dimen
无
2007-01-01
In this article, the low pressure axial flow fan with circumferential skewed rotor blade, including the radial blade, the forward-skewed blade and the backward-skewed blade, was studied with experimental methods. The aerodynamic performance of the rotors was measured. At the design condition at outlet of the rotors, detailed flow measurements were performed with a five-hole probe and a Hot-Wire Anemometer (HWA). The results show that compared to the radial rotor, the forward-skewed rotor demonstrates a wider Stable Operating Range (SOR), is able to reduce the total pressure loss in the hub region and make main loading of blade accumulating in the mid-span region. There is a wider wake in the upper mid-span region of the forward-skewed rotor. Compared to the radial rotor, in the backward-skewed rotor there is higher total pressure loss near the hub and shroud regions and lower loss in the mid-span region. In addition, the velocity deficit in the wake is lower at mid-span of the backward-skewed rotor than the forward-skewed rotor.
Smits, Iris A.M.; Timmerman, Marieke E.; Stegeman, Alwin
Maximum likelihood estimation of the linear factor model for continuous items assumes normally distributed item scores. We consider deviations from normality by means of a skew-normally distributed factor model or a quadratic factor model. We show that the item distributions under a skew-normal
P Shivakumara; G Hemantha Kumar; D S Guru; P Nagabhushan
2005-02-01
When a document is scanned either mechanically or manually for digitization, it often suffers from some degree of skew or tilt. Skew-angle detection plays an important role in the ﬁeld of document analysis systems and OCR in achieving the expected accuracy. In this paper, we consider skew estimation of Roman script. The method uses the boundary growing approach to extract the lowermost and uppermost coordinates of pixels of characters of text lines present in the document, which can be subjected to linear regression analysis (LRA) to determine the skew angle of a skewed document. Further, the proposed technique works ﬁne for scaled text binary documents also. The technique works based on the assumption that the space between the text lines is greater than the space between the words and characters. Finally, in order to evaluate the performance of the proposed methodology we compare the experimental results with those of well-known existing methods.
Djarmati, Ana; Schneider, Susanne A; Lohmann, Katja
2009-01-01
on to develop generalised dystonia. Thus, two of three patients with early-onset generalised dystonia with orobulbar involvement had mutations in THAP1. One of the identified patients with DYT6 dystonia had two family members with subtle motor signs who also carried the same mutation. A rare substitution...... increase the risk of dystonia. FUNDING: Deutsche Forschungsgemeinschaft; Volkswagen Foundation; Dystonia Medical Research Foundation; University of Lübeck....
F. Bartels
2000-01-01
textabstractFinal coalgebras of a functor F are suited for an abstract description of infinite datatypes and dynamical systems. Functions into such a domain are specified by coinductive definitions. The format these specifications take when their justification is directly based on finality is calle
Gc globulin as a diagnostic and prognostic marker in horses
Pihl, Tina Holberg
can prevent development of shock and thereby increase survival chances. The in vivo toxicity of Gc-globulin infusion is currently being investigated in horses and other species. Gc-globulin has been demonstrated in horse plasma and its structure closely resembles that of human Gc-globulin. Gc...
Volume overload cleanup: An approach for on-line SPE-GC, GPC-GC, and GPC-SPE-GC
Kerkdijk, H.; Mol, H.G.J.; Nagel, B. van der
2007-01-01
A new concept for cleanup, based on volume overloading of the cleanup column, has been developed for on-line coupling of gel permeation chromatography (GPC), solid-phase extraction (SPE), or both, to gas chromatography (GC). The principle is outlined and the applicability demonstrated by the determi
Koek, M.M.; Kloet, F.M. van der; Kleemann, R.; Kooistra, T.; Verheij, E.R.; Hankemeier, T.
2011-01-01
Due to the complexity of typical metabolomics samples and the many steps required to obtain quantitative data in GC × GC-MS consisting of deconvolution, peak picking, peak merging, and integration, the unbiased non-target quantification of GC × GC-MS data still poses a major challenge in metabolomic
Koehler, Jacob; Rawlings, Chris; Verrier, Paul; Mitchell, Rowan; Skusa, Andre; Ruegg, Alexander; Philippi, Stephan
2005-01-01
The structure of a closely integrated data warehouse is described that is designed to link different types and varying numbers of biological networks, sequence analysis methods and experimental results such as those coming from microarrays. The data schema is inspired by a combination of graph based methods and generalised data structures and makes use of ontologies and meta-data. The core idea is to consider and store biological networks as graphs, and to use generalised data structures (GDS) for the storage of further relevant information. This is possible because many biological networks can be stored as graphs: protein interactions, signal transduction networks, metabolic pathways, gene regulatory networks etc. Nodes in biological graphs represent entities such as promoters, proteins, genes and transcripts whereas the edges of such graphs specify how the nodes are related. The semantics of the nodes and edges are defined using ontologies of node and relation types. Besides generic attributes that most biological entities possess (name, attribute description), further information is stored using generalised data structures. By directly linking to underlying sequences (exons, introns, promoters, amino acid sequences) in a systematic way, close interoperability to sequence analysis methods can be achieved. This approach allows us to store, query and update a wide variety of biological information in a way that is semantically compact without requiring changes at the database schema level when new kinds of biological information is added. We describe how this datawarehouse is being implemented by extending the text-mining framework ONDEX to link, support and complement different bioinformatics applications and research activities such as microarray analysis, sequence analysis and modelling/simulation of biological systems. The system is developed under the GPL license and can be downloaded from http://sourceforge.net/projects/ondex/
Loes C J van Dam
2015-03-01
Full Text Available Humans can learn and store multiple visuomotor mappings (dual-adaptation when feedback for each is provided alternately. Moreover, learned context cues associated with each mapping can be used to switch between the stored mappings. However, little is known about the associative learning between cue and required visuomotor mapping, and how learning generalises to novel but similar conditions. To investigate these questions, participants performed a rapid target-pointing task while we manipulated the offset between visual feedback and movement end-points. The visual feedback was presented with horizontal offsets of different amounts, dependent on the targets shape. Participants thus needed to use different visuomotor mappings between target location and required motor response depending on the target shape in order to "hit" it. The target shapes were taken from a continuous set of shapes, morphed between spiky and circular shapes. After training we tested participants performance, without feedback, on different target shapes that had not been learned previously. We compared two hypotheses. First, we hypothesised that participants could (explicitly extract the linear relationship between target shape and visuomotor mapping and generalise accordingly. Second, using previous findings of visuomotor learning, we developed a (implicit Bayesian learning model that predicts generalisation that is more consistent with categorisation (i.e. use one mapping or the other. The experimental results show that, although learning the associations requires explicit awareness of the cues' role, participants apply the mapping corresponding to the trained shape that is most similar to the current one, consistent with the Bayesian learning model. Furthermore, the Bayesian learning model predicts that learning should slow down with increased numbers of training pairs, which was confirmed by the present results. In short, we found a good correspondence between the
Fuhrman, David R.; Fredsøe, Jørgen; Sumer, B. Mutlu
2009-01-01
contributions believed to play a prominent role in cross-shore boundary layer and sediment transport processes: (1) converging-diverging effects from bed slope, (2) wave skewness, (3) wave asymmetry, and (4) waves combined with superposed negative currents (intended to loosely represent, for example, return...... currents or undertow). The effects from each of the four components are isolated and quantified using a standard set of bed shear stress quantities, allowing their easy comparison. For conditions representing large shallow-water waves on steep slopes, the results suggest that converging-diverging effects...... from beach slope may make a significant onshore bed load contribution. Generally, however, the results suggest wave skewness (in addition to conventional steady streaming) as the most important onshore contribution outside the surf zone. Streaming induced within the wave boundary layer is also...
Muon Tracking Studies in a Skew Parametric Resonance Ionization Cooling Channel
Sy, Amy [Thomas Jefferson National Accelerator Facility, Newport News, VA (United States); Afanaciev, Andre [George Washington Univ., Washington, DC (United States); Derbenev, Yaroslav S. [Thomas Jefferson National Accelerator Facility, Newport News, VA (United States); Johnson, Rolland [Muons, Inc., Batavia, IL (United States); Morozov, Vasiliy [Thomas Jefferson National Accelerator Facility, Newport News, VA (United States)
2015-09-01
Skew Parametric-resonance Ionization Cooling (SPIC) is an extension of the Parametric-resonance Ionization Cooling (PIC) framework that has previously been explored as the final 6D cooling stage of a high-luminosity muon collider. The addition of skew quadrupoles to the PIC magnetic focusing channel induces coupled dynamic behavior of the beam that is radially periodic. The periodicity of the radial motion allows for the avoidance of unwanted resonances in the horizontal and vertical transverse planes, while still providing periodic locations at which ionization cooling components can be implemented. A first practical implementation of the magnetic field components required in the SPIC channel is modeled in MADX. Dynamic features of the coupled correlated optics with and without induced parametric resonance are presented and discussed.
Pindoriya, N.M.; Singh, S.N. [Department of Electrical Engineering, Indian Institute of Technology Kanpur, Kanpur 208016 (India); Singh, S.K. [Indian Institute of Management Lucknow, Lucknow 226013 (India)
2010-10-15
This paper proposes an approach for generation portfolio allocation based on mean-variance-skewness (MVS) model which is an extension of the classical mean-variance (MV) portfolio theory, to deal with assets whose return distribution is non-normal. The MVS model allocates portfolios optimally by considering the maximization of both the expected return and skewness of portfolio return while simultaneously minimizing the risk. Since, it is competing and conflicting non-smooth multi-objective optimization problem, this paper employed a multi-objective particle swarm optimization (MOPSO) based meta-heuristic technique to provide Pareto-optimal solution in a single simulation run. Using a case study of the PJM electricity market, the performance of the MVS portfolio theory based method and the classical MV method is compared. It has been found that the MVS portfolio theory based method can provide significantly better portfolios in the situation where non-normally distributed assets exist for trading. (author)
Research on the optimal structure configuration of dither RLG used in skewed redundant INS
Gao, Chunfeng; Wang, Qi; Wei, Guo; Long, Xingwu
2016-05-01
The actual combat effectiveness of weapon equipment is restricted by the performance of Inertial Navigation System (INS), especially in high reliability required situations such as fighter, satellite and submarine. Through the use of skewed sensor geometries, redundant technique has been applied to reduce the cost and improve the reliability of the INS. In this paper, the structure configuration and the inertial sensor characteristics of Skewed Redundant Strapdown Inertial Navigation System (SRSINS) using dithered Ring Laser Gyroscope (RLG) are analyzed. For the dither coupling effects of the dither gyro, the system measurement errors can be amplified either the individual gyro dither frequency is near one another or the structure of the SRSINS is unreasonable. Based on the characteristics of RLG, the research on coupled vibration of dithered RLG in SRSINS is carried out. On the principle of optimal navigation performance, optimal reliability and optimal cost-effectiveness, the comprehensive evaluation scheme of the inertial sensor configuration of SRINS is given.
Tang, An-Min; Tang, Nian-Sheng
2015-02-28
We propose a semiparametric multivariate skew-normal joint model for multivariate longitudinal and multivariate survival data. One main feature of the posited model is that we relax the commonly used normality assumption for random effects and within-subject error by using a centered Dirichlet process prior to specify the random effects distribution and using a multivariate skew-normal distribution to specify the within-subject error distribution and model trajectory functions of longitudinal responses semiparametrically. A Bayesian approach is proposed to simultaneously obtain Bayesian estimates of unknown parameters, random effects and nonparametric functions by combining the Gibbs sampler and the Metropolis-Hastings algorithm. Particularly, a Bayesian local influence approach is developed to assess the effect of minor perturbations to within-subject measurement error and random effects. Several simulation studies and an example are presented to illustrate the proposed methodologies.
Optimization Design and Experimental Study of Low-Pressure Axial Fan with Forward-Skewed Blades
Li Yang
2007-01-01
Full Text Available This paper presents an experimental study of the optimization of blade skew in low pressure axial fan. Using back propagation (BP neural network and genetic algorithm (GA, the optimization was performed for a radial blade. An optimized blade is obtained through blade forward skew. Measurement of the two blades was carried out in aerodynamic and aeroacoustic performance. Compared to the radial blade, the optimized blade demonstrated improvements in efficiency, total pressure ratio, stable operating range, and aerodynamic noise. Detailed flow measurement was performed in outlet flow field for investigating the responsible flow mechanisms. The optimized blade can cause a spanwise redistribution of flow toward the blade midspan and reduce tip loading. This results in reduced significantly total pressure loss near hub and shroud endwall region, despite the slight increase of total pressure loss at midspan. In addition, the measured spectrums show that the broadband noise of the impeller is dominant.
Skew ray tracing in a step-index optical fiber using Geometric Algebra
Ang, Angeleene; McNamara, Daniel J
2015-01-01
We used Geometric Algebra to compute the paths of skew rays in a cylindrical, step-index multimode optical fiber. To do this, we used the vector addition form for the law of propagation, the exponential of an imaginary vector form for the law of refraction, and the juxtaposed vector product form for the law of reflection. In particular, the exponential forms of the vector rotations enables us to take advantage of the addition or subtraction of exponential arguments of two rotated vectors in the derivation of the ray tracing invariants in cylindrical and spherical coordinates. We showed that the light rays inside the optical fiber trace a polygonal helical path characterized by three invariants that relate successive reflections inside the fiber: the ray path distance, the difference in axial distances, and the difference in the azimuthal angles. We also rederived the known generalized formula for the numerical aperture for skew rays, which simplifies to the standard form for meridional rays.
SKEWNESS IN STOCK RETURNS: EVIDENCE FROM THE BUCHAREST STOCK EXCHANGE DURING 2000 – 2011
IULIAN PANAIT
2012-05-01
Full Text Available Our paper investigates the symmetry in stock returns of the 30 most liquid companies traded on Bucharest Stock Exchange during 2000 – 2011 and also the most representative 5 market indices. Our daily data shows that skewness estimates are slightly negative for most indices and individual stocks, but only a few present values significantly different from the characteristics of a normal distribution. We compare our results with skewness estimates for 21 major and emerging stock market indices around the world and find that such results are similar to other low capitalization and trading volume markets. For all the Romanian and international assets studied, the Studentized-Range (St-R and Jarque-Bera (J-B tests reject the hypothesis of normal distribution of daily returns.
Remaining useful life prediction for an adaptive skew-Wiener process model
Huang, Zeyi; Xu, Zhengguo; Ke, Xiaojie; Wang, Wenhai; Sun, Youxian
2017-03-01
Predicting the remaining useful life for operational devices plays a critical role in prognostics and health management. As the models based on the stochastic processes are widely used for characterizing the degradation trajectory, an adaptive skew-Wiener model, which is much more flexible than traditional stochastic process models, is proposed to model the degradation drift of industrial devices. To make full use of the prior knowledge and the historical information, an on-line filtering algorithm is proposed for state estimation, a two-stage algorithm is adopted to estimate unknown parameters as well. For remaining useful life prediction, a novel result is presented with an explicit form based on the closed skew normal distribution. Finally, sufficient Monte Carlo simulations and an application for ball bearings in rotating electrical machines are used to validate our approach.
Dlugosz, Stephan; Mammen, Enno; Wilke, Ralf
We consider the semiparametric generalised linear regression model which has mainstream empirical models such as the (partially) linear mean regression, logistic and multinomial regression as special cases. As an extension to related literature we allow a misclassified covariate to be interacted...... with a nonparametric function of a continuous covariate. This model is tailormade to address known data quality issues of administrative labour market data. Using a sample of 20m observations from Germany we estimate the determinants of labour market transitions and illustrate the role of considerable...
Deformation due to mechanical and thermal sources in generalised orthorhombic thermoelastic material
Rajneesh Kumar; Leena Rani
2004-10-01
A dynamical two-dimensional problem of thermoelasticity has been considered to investigate the disturbance due to mechanical (horizontal or vertical) and thermal source in a homogeneous, thermally conducting orthorhombic material. Laplace–Fourier transforms are applied to basic equations to form a vector matrix differential equation, which is then solved by eigenvalue approach. The displacements, stresses and temperature distribution so obtained in the physical domain are computed numerically and illustrated graphically. The numerical results of these quantities for zinc crystal-like material are illustrated to compare the results for different theories of generalised thermoelasticity for an insulated boundary and a temperature gradient boundary.
On completeness of coherent states in noncommutative spaces with generalised uncertainty principle
Dey, Sanjib
2016-01-01
Coherent states are required to form a complete set of vectors in the Hilbert space by providing the resolution of identity. We study the completeness of coherent states for two different models in a noncommutative space associated with the generalised uncertainty relation by finding the resolution of unity with a positive definite weight function. The weight function, which is sometimes known as the Borel measure, is obtained through explicit analytic solutions of the Stieltjes and Hausdorff moment problem with the help of the standard techniques of inverse Mellin transform.
Knee function in 10-year-old children and adults with Generalised Joint Hypermobility
Juul-Kristensen, Birgit; Hansen, Henrik; Simonsen, Erik B;
2012-01-01
PURPOSE: Knee function is reduced in patients with Benign Joint Hypermobility Syndrome. The aim was to study knee function in children and adults with Generalised Joint Hypermobility (GJH) and Non-GJH (NGJH)). MATERIALS AND METHODS: In a matched comparative study, 39 children and 36 adults (mean...... age children 10.2years; adults 40.3years) were included, comprising 19 children and 18 adults with GJH (Beighton =5/9; Beighton =4/9), minimum one hypermobile knee, no knee pain (children), and 20 children and 18 adults with NGJH (Beighton...
Lam, P K; Wong, T W; Chan, Y C; Mak, Tony W L
2014-12-01
Mesobuthus martensii Karsch, commonly known as the Chinese scorpion or Manchurian scorpion, has been used in traditional Chinese medicine as Quanxie to treat chronic pain, tetanus, tremors, convulsion, and paralysis for more than a thousand years. We report a case of poisoning after ingestion of a teaspoon of Quanxie powder. The patient presented with chest pain, dizziness, diaphoresis, generalised involuntary limb twitching, and hypertonia around 15 minutes post-ingestion. The patient recovered uneventfully after supportive management. Intravenous diazepam appeared to be effective in alleviating limb twitching. Failure to accurately measure the dose and to boil before consumption may have contributed to his clinical toxicities.
Damgård, Ivan Bjerre; Jurik, Mads Johan
2001-01-01
to t out of L candidates. The same basic building blocks can also be adapted to provide receipt-free elections, under appropriate physical assumptions. The scheme for 1 out of L elections can be optimised such that for a certain range of parameter values, a ballot has size only O(log L) bits....... is as secure as Paillier's original system. We construct a threshold variant of the generalised scheme as well as zero-knowledge protocols to show that a given ciphertext encrypts one of a set of given plaintexts, and protocols to verify multiplicative relations on plaintexts. We then show how these building...
The $Q^{2}$-dependence of the Generalised Gerasimov-Drell-Hearn Integral for the Proton
Airapetian, A; Akushevich, I V; Amarian, M; Arrington, J; Aschenauer, E C; Avakian, H; Avakian, R; Avetisian, A; Avetissian, E; Bailey, P; Bains, B; Baumgarten, C; Beckmann, M; Belostotskii, S; Bernreuther, S; Bianchi, N; Böttcher, Helmut B; Borisov, A; Bouwhuis, M; Brack, J; Brauksiepe, S; Brauniu, B; Brückner, W; Brüll, A; Budz, P; Bulten, H J; Capitani, G P; Carter, P; Chumney, P; Cisbani, E; Court, G R; Dalpiaz, P F; De Leo, R; De Nardo, L; De Sanctis, E; De Schepper, D; Devitsin, E G; De Witt-Huberts, P K A; Di Nezza, P; Dzhordzhadze, V; Düren, M; Dvoredsky, A P; Elbakian, G M; Ely, J; Fantoni, A; Feshchenko, A; Ferro-Luzziwad, M; Fiedler, K; Filippone, B W; Fischer, H; Fox, B; Franzl, J; Frullani, S; Gärber, Y; Garibaldi, F; Garutti, E; Gavrilov, G E; Karibian, V; Golendukhin, A; Graw, G; Grebenyuk, O; Green, P W; Greeniaus, L G; Gute, A; Haeberli, W; Hartig, M; Hasch, D; Heesbeen, D; Heinsius, F H; Henoch, M; Hertenberger, R; Hesselink, W H A; Hoffmann-Rothe, P; Hofman, G J; Holler, Y; Holto, R J; Hommez, B; Iarygin, G; Iodice, M; Izotov, A A; Jackson, H E; Jgoun, A; Jung, P; Kaiser, R; Kanesakaac, J; Kinney, E R; Kiselev, A; Kitching, P; Kobayashi, H; Koch, N; Königsmann, K C; Kolster, H; Korotkov, V A; Kotik, E; Kozlov, V; Krivokhizhin, V G; Kyle, G S; Lagamba, L; Laziev, A; Lenisa, P; Lindemann, T; Lorenzon, W; Makins, N C R; Martin, J W; Marukyan, H O; Masoli, F; McAndrew, M; McIlhany, K; McKeown, R D; Menden, F; Metzu, A; Meyners, N; Miklukho, O; Miller, C A; Milner, R; Mitsyn, V; Muccifora, V; Mussa, R; Nagaitsev, A P; Nappi, E; Naryshkin, Yu; Nass, A; Negodaeva, K; Nowak, Wolf-Dieter; O'Neill, T G; Openshaw, R; Ouyang, J; Owen, B R; Pate, S F; Potashov, S Yu; Potterveld, D H; Rakness, G; Rappoport, V; Redwine, R P; Reggiani, D; Reolon, A R; Ristinen, R; Rith, K; Robinson, D; Ruh, M; Ryckbosch, D; Sakemi, Y; Savin, I A; Scarlett, C; Schäfer, A; Schill, C; Schmidt, F; Schnell, G; Schulerf, K P; Schwind, A; Seibert, J; Seitz, B; Shibata, T A; Shin, T; Shutov, V B; Simani, C; Simon, A; Sinram, K; Steffens, E; Steijger, J J M; Stewart, J; Stösslein, U; Suetsugu, K; Sutter, M F; Tallini, H A; Taroian, S P; Terkulov, A R; Tessarin, S; Thomas, E; Tipton, B; Tytgat, M; Urciuoli, G M; Van den Brand, J F J; van der Steenhoven, G; Van de Vyver, R; Van Hunen, J J; Vetterli, Martin C; Vikhrov, V V; Vincter, M G; Visser, J; Volk, E; Weiskopf, C; Wendland, J; Wilbert, J; Wiseq, T; Yen, S; Yoneyama, S; Zohrabyan, H G
2000-01-01
The dependence on Q^2 (the negative square of the 4-momentum of the exchanged virtual photon) of the generalised Gerasimov-Drell-Hearn integral for the proton has been measured in the range 1.2 GeV^2 3 GeV^2, while both contributions are important at low Q^2. The total integral shows no significant deviation from a 1/Q^2 behaviour in the measured Q^2 range, and thus no sign of large effects due to either nucleon-resonance excitations or non-leading twist.
Generalised universality of gauge thresholds in heterotic vacua with and without supersymmetry
Carlo Angelantonj
2015-11-01
Full Text Available We study one-loop quantum corrections to gauge couplings in heterotic vacua with spontaneous supersymmetry breaking. Although in non-supersymmetric constructions these corrections are not protected and are typically model dependent, we show how a universal behaviour of threshold differences, typical of supersymmetric vacua, may still persist. We formulate specific conditions on the way supersymmetry should be broken for this to occur. Our analysis implies a generalised notion of threshold universality even in the case of unbroken supersymmetry, whenever extra charged massless states appear at enhancement points in the bulk of moduli space. Several examples with universality, including non-supersymmetric chiral models in four dimensions, are presented.
Generalised 2D-correlation NMR analysis of a wine fermentation.
Kirwan, Gemma M; Clark, Shona; Barnett, Neil W; Niere, Julie O; Adams, Michael J
2008-11-23
A wine fermentation has been monitored on a daily basis by (1)H NMR spectroscopy. Following data pre-processing that includes synthesis of the spectra to ensure all peaks are of constant half-width, the series of spectra were examined using generalised two-dimensional correlation techniques. Synchronous and asynchronous data maps have been generated and employed to interpret the changes in the fermentation process as a function of time. The results illustrate the potential of high resolution NMR with multivariate data analysis as a tool for process monitoring and the manner in which two-dimensional correlation mapping can aid in data interpretation.
Generalised Cornu spirals: an experimental study using hard x-rays.
Werdiger, Freda; Kitchen, Marcus J; Paganin, David M
2016-05-16
The Cornu spiral is a graphical aid that has been used historically to evaluate Fresnel integrals. It is also the Argand-plane mapping of a monochromatic complex scalar plane wave diffracted by a hard edge. We have successfully reconstructed a Cornu spiral due to diffraction of hard x-rays from a piece of Kapton tape. Additionally, we have explored the generalisation of the Cornu spiral by observing the Argand-plane mapping of complex scalar electromagnetic fields diffracted by a cylinder and a sphere embedded within a cylinder.
Generalised universality of gauge thresholds in heterotic vacua with and without supersymmetry
Angelantonj, Carlo; Tsulaia, Mirian
2015-01-01
We study one-loop quantum corrections to gauge couplings in heterotic vacua with spontaneous supersymmetry breaking. Although in non-supersymmetric constructions these corrections are not protected and are typically model dependent, we show how a universal behaviour of threshold differences, typical of supersymmetric vacua, may still persist. We formulate specific conditions on the way supersymmetry should be broken for this to occur. Our analysis implies a generalised notion of threshold universality even in the case of unbroken supersymmetry, whenever extra charged massless states appear at enhancement points in the bulk of moduli space. Several examples with universality, including non-supersymmetric chiral models in four dimensions, are presented.
Measuring skewness of red blood cell deformability distribution by laser ektacytometry
Nikitin, S Yu; Priezzhev, A V; Lugovtsov, A E [International Laser Center, M. V. Lomonosov Moscow State University, Moscow (Russian Federation); Ustinov, V D [M. V. Lomonosov Moscow State University, Faculty of Computational Mathematics and Cybernetics, Moscow (Russian Federation)
2014-08-31
An algorithm is proposed for measuring the parameters of red blood cell deformability distribution based on laser diffractometry of red blood cells in shear flow (ektacytometry). The algorithm is tested on specially prepared samples of rat blood. In these experiments we succeeded in measuring the mean deformability, deformability variance and skewness of red blood cell deformability distribution with errors of 10%, 15% and 35%, respectively. (laser biophotonics)
On the skew-bounded minimum-buffer routing tree problem
Albrecht, C.; Kahng, A B; Liu, B.; Mandoiu, Ion I.; Zelikovsky, A Z
2003-01-01
Bounding the load capacitance at gate outputs is a standard element in today's electrical correctness methodologies for high-speed digital very large scale integration design. Bounds on load caps improve coupling-noise immunity, reduce degradation of signal transition edges, and reduce delay uncertainty due to coupling noise (Kahng et al. 1998). For clock and test distribution, an additional design requirement is bounding the buffer skew, i.e., the difference between the maximum and the minim...
Expanding the mission plan for large scale telescope systems via skew path optical conditioners
Savastinuk, John; Palmer, Troy A.; Alexay, Christopher
2017-05-01
We describe a case study in which a telescope system, originally designed for a large format, visible camera, needed MWIR imaging capabilities while maintaining its original setup. The dedicated telescope system was adapted to share its existing optics with a new imaging module via a skew path concept. The challenges of non-rotationally symmetric design are explored along with an explanation of the methodology used to analyze and address the unique configuration.
Enhanced Skewed Load and Broadside Power Reduction in Transition Fault Testing
Mrs. A.Jyothi
2014-10-01
Full Text Available This Paper Proposes the T-algorithm technique to optimize the testing Skewed Load and Broadside architecture. And the architecture used to the compare the test pattern results. In this architecture, T-algorithm used to optimize the testing architecture. This architecture compare the test pattern output for the required any type of combinational architecture. The optimization process mainly focused by gate optimization for secure architecture. The proposed system to use the T-algorithm, to optimize the testing clocking level for the required test patterns. This technique to replace the flip flop and the mux arrangement. To reduce the flip flops in Skewed Load architecture. And to develop the accuracy for testing architecture. The proposed system consists of the secure testing architecture and includes the XOR-gate architecture. So the modification process applied by the Broadside and over all Skewed Load architecture. The proposed technique to check the scanning results for the testing process. The testing architecture mainly used to the error attack for the scanning process and the scanning process work with any type of testing architecture. The scanning process to be secure using the T-algorithm for the Skewed Load architecture. And to develop the testing process for the fault identification process. The diagnosis technique to detect error for the scanning process in any type combinational architecture. The T-algorithm used to reduce the circuit complexity for the testing architecture and the testing architecture used to reduce the delay level. And the future process, this technique used to reduce the gate level for the sticky comparator architecture and to modify the clocking function for the testing process. This technique to develop the accuracy level for the testing process compare to the present methodology.
Effect of Phase Response Curve Skew on Synchronization with and without Conduction Delays
Carmen eCanavier
2013-12-01
Full Text Available A central problem in cortical processing including sensory binding and attentional gating is how neurons can synchronize their responses with zero or near-zero time lag. For a spontaneously firing neuron, an input from another neuron can delay or advance the next spike by different amounts depending upon the timing of the input relative to the previous spike. This information constitutes the phase response curve (PRC. We present a simple graphical method for determining the effect of PRC shape on synchronization tendencies and illustrate it using type 1 PRCs, which consist entirely of advances (delays in response to excitation (inhibition. We obtained the following generic solutions for type 1 PRCs, which include the pulse coupled leaky integrate and fire model. For pairs with mutual excitation, exact synchrony can be stable for strong coupling because of the stabilizing effect of the causal limit region of the PRC in which an input triggers a spike immediately upon arrival. However, synchrony is unstable for short delays, because delayed inputs arrive during a refractory period and cannot trigger an immediate spike. Right skew destabilizes antiphase and enables modes with time lags that grow as the conduction delay is increased. Therefore, right skew favors near-synchrony at short conduction delays and a gradual transition between synchrony and antiphase for pairs coupled by mutual excitation. For pairs with mutual inhibition, zero time lag synchrony is stable for conduction delays ranging from zero to a substantial fraction of the period for pairs. However, for right skew there is a preferred antiphase mode at short delays. In contrast to mutual excitation, left skew destabilizes antiphase for mutual inhibition so that synchrony dominates at short delays as well. These pairwise synchronization tendencies constrain the synchronization properties of neurons embedded in larger networks.
Longcope, D W
2010-01-01
In models of fast magnetic reconnection, flux transfer occurs within a small portion of a current sheet triggering stored magnetic energy to be thermalized by shocks. When the initial current sheet separates magnetic fields which are not perfectly anti-parallel, i.e. they are skewed, magnetic energy is first converted to bulk kinetic energy and then thermalized in slow magnetosonic shocks. We show that the latter resemble parallel shocks or hydrodynamic shocks for all skew angles except those very near the anti-parallel limit. As for parallel shocks, the structures of reconnection-driven slow shocks are best studied using two-fluid equations in which ions and electrons have independent temperature. Time-dependent solutions of these equations can be used to predict and understand the shocks from reconnection of skewed magnetic fields. The results differ from those found using a single-fluid model such as magnetohydrodynamics. In the two-fluid model electrons are heated indirectly and thus carry a heat flux alw...
A Bayesian estimate of the concordance correlation coefficient with skewed data.
Feng, Dai; Baumgartner, Richard; Svetnik, Vladimir
2015-01-01
Concordance correlation coefficient (CCC) is one of the most popular scaled indices used to evaluate agreement. Most commonly, it is used under the assumption that data is normally distributed. This assumption, however, does not apply to skewed data sets. While methods for the estimation of the CCC of skewed data sets have been introduced and studied, the Bayesian approach and its comparison with the previous methods has been lacking. In this study, we propose a Bayesian method for the estimation of the CCC of skewed data sets and compare it with the best method previously investigated. The proposed method has certain advantages. It tends to outperform the best method studied before when the variation of the data is mainly from the random subject effect instead of error. Furthermore, it allows for greater flexibility in application by enabling incorporation of missing data, confounding covariates, and replications, which was not considered previously. The superiority of this new approach is demonstrated using simulation as well as real-life biomarker data sets used in an electroencephalography clinical study. The implementation of the Bayesian method is accessible through the Comprehensive R Archive Network.
Free vibration of composite skewed cylindrical shell panel by finite element method
Haldar, Salil
2008-03-01
In this paper a composite triangular shallow shell element has been used for free vibration analysis of laminated composite skewed cylindrical shell panels. In the present element first-order shear deformation theory has been incorporated by taking transverse displacement and bending rotations as independent field variables. The interpolation function used to approximate transverse displacement is one order higher than for bending rotations. This has made the element free from locking in shear. Two types of mass lumping schemes have been recommended. In one of the mass lumping scheme the effect of rotary inertia has been incorporated in the element formulations. Free vibration of skewed composite cylindrical shell panels having different thickness to radius ratios ( h/R=0.01-0.2), length to radius ratios ( L/R), number of layers and fiber orientation angles have been analyzed following the shallow shell method. The results for few examples obtained in the present analysis have compared with the published results. Some new results of composite skewed cylindrical shell panels have been presented which are expected to be useful to future research in this direction.
Delivering Left-Skewed Portfolio Payoff Distributions in the Presence of Transaction Costs
Jacek B Krawczyk
2015-08-01
Full Text Available For pension-savers, a low payoff is a financial disaster. Such investors will most likely prefer left-skewed payoff distributions over right-skewed payoff distributions. We explore how such distributions can be delivered. Cautious-relaxed utility measures are cautious in ensuring that payoffs don’t fall much below a reference value, but relaxed about exceeding it. We find that the payoff distribution delivered by a cautious-relaxed utility measure has appealing features which payoff distributions delivered by traditional utility functions don’t. In particular, cautious-relaxed distributions can have the mass concentrated on the left, hence be left-skewed. However, cautious-relaxed strategies prescribe frequent portfolio adjustments which may be expensive if transaction costs are charged. In contrast, more traditional strategies can be time-invariant. Thus we investigate the impact of transaction costs on the appeal of cautious-relaxed strategies. We find that relatively high transaction fees are required for the cautious-relaxed strategy to lose its appeal. This paper contributes to the literature which compares utility measures by the payoff distributions they produce and finds that a cautious-relaxed utility measure will deliver payoffs that many investors will prefer.
Aberration compensation in a Skew parametric-resonance ionization cooling channel
Sy, Amy V. [Thomas Jefferson National Accelerator Facility (TJNAF), Newport News, VA (United States); Derbenev, Yaroslav S. [Thomas Jefferson National Accelerator Facility (TJNAF), Newport News, VA (United States); Morozov, Vasiliy [Thomas Jefferson National Accelerator Facility (TJNAF), Newport News, VA (United States); Afanasev, Andrei [George Washington Univ., Washington, DC (United States); Thomas Jefferson National Accelerator Facility (TJNAF), Newport News, VA (United States); Bao, Y. [Univ. of California, Riverside, CA (United States); Johnson, Rolland P. [Muons Inc., Batavia, IL (United States)
2017-05-01
Skew Parametric-resonance Ionization Cooling (Skew PIC) represents a novel method for focusing of highly divergent particle beams, as in the final 6D cooling stage of a high-luminosity muon collider. In the muon collider concept, the resultant equilibrium transverse emittances from cooling with Skew PIC are an order of magnitude smaller than in conventional ionization cooling. The concept makes use of coupling of the transverse dynamic behavior, and the linear dynamics are well-behaved with good agreement between analytic solutions and simulation results. Compared to the uncoupled system, coupling of the transverse dynamic behavior purports to reduce the number of multipoles required for aberration compensation while also avoiding unwanted resonances. Aberration compensation is more complicated in the coupled case, especially in the high-luminosity muon collider application where equilibrium angular spreads in the cooling channel are on the order of 200 mrad. We present recent progress on aberration compensation for control of highly divergent muon beams in the coupled correlated optics channel, and a simple cooling model to test the transverse acceptance of the channel.
Buffeting response of long-span cable-supported bridges under skew winds. Part 1: theory
Zhu, L. D.; Xu, Y. L.
2005-03-01
A finite-element-based framework for buffeting analysis of long-span cable-supported bridges under skew winds is developed in the frequency domain utilizing the linear quasi-steady theory and the strip theory of aerodynamics in conjunction with the pseudo excitation method. A set of universal expressions for six components of buffeting forces is first derived in association with oblique cross-sections of bridge components, in which the buffeting forces are formed with respect to the wind coordinate system and then converted to those with respect to the structural coordinate system. Skew mean wind and three orthogonal components of velocity fluctuations can thus be easily handled without any further decomposition. The coherence between velocity fluctuations of wind turbulence at any two arbitrary spatial points is considered in the global wind coordinate system rather than in the global structural coordinate system. Aeroelastic stiffness and damping matrices due to self-excited forces are then taken into consideration in terms of the 18 flutter derivatives with respect to the oblique cross-sections. The pseudo-excitation method is finally employed to solve efficiently the fully coupled 3D buffeting problem of long-span cable-supported bridges under skew winds with the effects of multi-modes and spatial modes, inter-mode coupling and aerodynamic coupling, and the interaction among major bridge components being naturally included.
Denner, Fabian; van Wachem, Berend G. M.
2015-10-01
Total variation diminishing (TVD) schemes are a widely applied group of monotonicity-preserving advection differencing schemes for partial differential equations in numerical heat transfer and computational fluid dynamics. These schemes are typically designed for one-dimensional problems or multidimensional problems on structured equidistant quadrilateral meshes. Practical applications, however, often involve complex geometries that cannot be represented by Cartesian meshes and, therefore, necessitate the application of unstructured meshes, which require a more sophisticated discretisation to account for their additional topological complexity. In principle, TVD schemes are applicable to unstructured meshes, however, not all the data required for TVD differencing is readily available on unstructured meshes, and the solution suffers from considerable numerical diffusion as a result of mesh skewness. In this article we analyse TVD differencing on unstructured three-dimensional meshes, focusing on the non-linearity of TVD differencing and the extrapolation of the virtual upwind node. Furthermore, we propose a novel monotonicity-preserving correction method for TVD schemes that significantly reduces numerical diffusion caused by mesh skewness. The presented numerical experiments demonstrate the importance of accounting for the non-linearity introduced by TVD differencing and of imposing carefully chosen limits on the extrapolated virtual upwind node, as well as the efficacy of the proposed method to correct mesh skewness.
Materna, K.; Herring, T.
2013-12-01
Error in modeling atmospheric delay is one of the limiting factors in the accuracy of GPS position determination. In regions with uneven topography, atmospheric delay phenomena can be especially complicated. Current delay models used in analyzing daily GPS data from the Plate Boundary Observatory (PBO) are successful in achieving millimeter-level accuracy at most locations; however, at a subset of stations, the time-series for position estimates contain an unusually large number of outliers. In many cases these outliers are oriented in the same direction. The stations which exhibit asymmetric outliers occur in various places across the PBO network, but they are especially numerous in California's Mammoth Lakes region, which served as a case study for this presentation. The phenomenon was analyzed by removing secular trends and variations with periods longer than 75 days from the signal using a median filter. We subsequently calculated the skewness of the station position residuals in north, east and up directions. In the cases examined, typical position outliers are 5-15 mm. In extreme cases, skewed position residuals, not related to snow on antennas, can be as large as 20 mm. We examine the causes of the skewness through site-by-site comparisons with topographic data and numerical weather models. Analysis suggests that the direction of the skewness is generally parallel to the local topographic gradient at a scale of several kilometers, and that outlier data points occur when certain atmospheric conditions are met. The results suggest that a coupling between the atmosphere and local topography is responsible for the phenomenon of skewed residuals. In this presentation, we examine the characteristics of the sites that we have analyzed in detail. From these analyses, we postulate possible parameterizations of the atmospheric and topographic effects that could be incorporated into geodetic analysis programs, thus allowing the inhomogeneous atmospheric delays to be
Coil Creep and Skew-Quadrupole Field Components in the Tevatron
Annala, G.; Harding, D.J.; Syphers, M.J.; /Fermilab
2011-07-11
During the start-up of Run II of the Tevatron Collider program, several issues surfaced which were not present, or not seen as detrimental, during Run I. These included the repeated deterioration of the closed orbit requiring orbit smoothing every two weeks or so, the inability to correct the closed orbit to desired positions due to various correctors running at maximum limits, regions of systematically strong vertical dipole corrections, and the identification of very strong coupling between the two transverse degrees-of-freedom. It became apparent that many of the problems being experienced operationally were connected to a deterioration of the main dipole magnet alignment, and remedial actions were undertaken. However, the alignment alone was not enough to explain the corrector strengths required to handle transverse coupling. With one exception, strong coupling had generally not been an issue in the Tevatron during Run I. Based on experience with the Main Ring, the Tevatron was designed with a very strong skew quadrupole circuit to compensate any quadrupole alignment and skew quadrupole field errors that might present themselves. The circuit was composed of 48 correctors placed evenly throughout the arcs, 8 per sector, evenly placed in every other cell. Other smaller circuits were installed but not initially needed or commissioned. These smaller circuits were composed of individual skew quadrupole correctors on either side of the long straight sections. These circuits were tuned by first bringing the horizontal and vertical tunes near each other. The skew quadrupoles were then adjusted to minimize tune split, usually to less than 0.003. Initially, the main skew quad circuit (designated T:SQ) could accomplish this global decoupling with only 4% of its possible current, and the smaller circuits were not required at all. The start-up of Run Ib was complicated by what was later discovered to be a rolled triplet quadrupole magnet in one of the Interaction Regions
Efficacy of oral afoxolaner for the treatment of canine generalised demodicosis
Beugnet Frédéric
2016-01-01
Full Text Available The efficacy of oral treatment with a chewable tablet containing afoxolaner 2.27% w/w (NexGard®, Merial administered orally was assessed in eight dogs diagnosed with generalised demodicosis and compared with efficacy in eight dogs under treatment with a topical combination of imidacloprid/moxidectin (Advocate®, Bayer. Afoxolaner was administered at the recommended dose (at least 2.5 mg/kg on Days 0, 14, 28 and 56. The topical combination of imidacloprid/moxidectin was given at the same intervals at the recommended concentration. Clinical examinations and deep skin scrapings were performed every month in order to evaluate the effect on mite numbers and the resolution of clinical signs. The percentage reductions of mite counts were 99.2%, 99.9% and 100% on Days 28, 56 and 84, respectively, in the afoxolaner-treated group, compared to 89.8%, 85.2% and 86.6% on Days 28, 56 and 84 in the imidacloprid/moxidectin-treated group. Skin condition of the dogs also improved significantly from Day 28 to Day 84 in the afoxolaner-treated group. Mite reductions were significantly higher on Days 28, 56 and 84 in the afoxolaner-treated group compared to the imidacloprid/moxidectin-treated group. The results of this study demonstrated that afoxolaner, given orally, was effective in treating dogs with generalised demodicosis within a two-month period.
Efficacy of oral afoxolaner for the treatment of canine generalised demodicosis.
Beugnet, Frédéric; Halos, Lénaïg; Larsen, Diane; de Vos, Christa
2016-01-01
The efficacy of oral treatment with a chewable tablet containing afoxolaner 2.27% w/w (NexGard(®), Merial) administered orally was assessed in eight dogs diagnosed with generalised demodicosis and compared with efficacy in eight dogs under treatment with a topical combination of imidacloprid/moxidectin (Advocate(®), Bayer). Afoxolaner was administered at the recommended dose (at least 2.5 mg/kg) on Days 0, 14, 28 and 56. The topical combination of imidacloprid/moxidectin was given at the same intervals at the recommended concentration. Clinical examinations and deep skin scrapings were performed every month in order to evaluate the effect on mite numbers and the resolution of clinical signs. The percentage reductions of mite counts were 99.2%, 99.9% and 100% on Days 28, 56 and 84, respectively, in the afoxolaner-treated group, compared to 89.8%, 85.2% and 86.6% on Days 28, 56 and 84 in the imidacloprid/moxidectin-treated group. Skin condition of the dogs also improved significantly from Day 28 to Day 84 in the afoxolaner-treated group. Mite reductions were significantly higher on Days 28, 56 and 84 in the afoxolaner-treated group compared to the imidacloprid/moxidectin-treated group. The results of this study demonstrated that afoxolaner, given orally, was effective in treating dogs with generalised demodicosis within a two-month period.
Navigation towards a goal position: from reactive to generalised learned control
Freire da Silva, Valdinei [Laboratorio de Tecnicas Inteligentes - LTI, Escola Politecnica da Universidade de Sao Paulo, Av. Prof. Luciano Gualberto, trav.3, n.158, Cidade Universitaria Sao Paulo (Brazil); Selvatici, Antonio Henrique [Universidade Nove de Julho, Rua Vergueiro, 235, Sao Paulo (Brazil); Reali Costa, Anna Helena, E-mail: valdinei.freire@gmail.com, E-mail: antoniohps@uninove.br, E-mail: anna.reali@poli.usp.br [Laboratorio de Tecnicas Inteligentes - LTI, Escola Politecnica da Universidade de Sao Paulo, Av. Prof. Luciano Gualberto, trav.3, n.158, Cidade Universitaria Sao Paulo (Brazil)
2011-03-01
The task of navigating to a target position in space is a fairly common task for a mobile robot. It is desirable that this task is performed even in previously unknown environments. One reactive architecture explored before addresses this challenge by denning a hand-coded coordination of primitive behaviours, encoded by the Potential Fields method. Our first approach to improve the performance of this architecture adds a learning step to autonomously find the best way to coordinate primitive behaviours with respect to an arbitrary performance criterion. Because of the limitations presented by the Potential Fields method, especially in relation to non-convex obstacles, we are investigating the use of Relational Reinforcement Learning as a method to not only learn to act in the current environment, but also to generalise prior knowledge to the current environment in order to achieve the goal more quickly in a non-convex structured environment. We show the results of our previous efforts in reaching goal positions along with our current research on generalised approaches.
Chun, Tae Yoon; Lee, Jae Young; Park, Jin Bae; Choi, Yoon Ho
2016-03-01
In this paper, we analyse the convergence and stability properties of generalised policy iteration (GPI) applied to discrete-time linear quadratic regulation problems. GPI is one kind of the generalised adaptive dynamic programming methods used for solving optimal control problems, and is composed of policy evaluation and policy improvement steps. To analyse the convergence and stability of GPI, the dynamic programming (DP) operator is defined. Then, GPI and its equivalent formulas are presented based on the notation of DP operator. The convergence of the approximate value function to the exact one in policy evaluation is proven based on the equivalent formulas. Furthermore, the positive semi-definiteness, stability, and the monotone convergence (PI-mode and VI-mode convergence) of GPI are presented under certain conditions on the initial value function. The online least square method is also presented for the implementation of GPI. Finally, some numerical simulations are carried out to verify the effectiveness of GPI as well as to further investigate the convergence and stability properties.
Lepton mixing predictions including Majorana phases from Δ(6n2 flavour symmetry and generalised CP
Stephen F. King
2014-09-01
Full Text Available Generalised CP transformations are the only known framework which allows to predict Majorana phases in a flavour model purely from symmetry. For the first time generalised CP transformations are investigated for an infinite series of finite groups, Δ(6n2=(Zn×Zn⋊S3. In direct models the mixing angles and Dirac CP phase are solely predicted from symmetry. The Δ(6n2 flavour symmetry provides many examples of viable predictions for mixing angles. For all groups the mixing matrix has a trimaximal middle column and the Dirac CP phase is 0 or π. The Majorana phases are predicted from residual flavour and CP symmetries where α21 can take several discrete values for each n and the Majorana phase α31 is a multiple of π. We discuss constraints on the groups and CP transformations from measurements of the neutrino mixing angles and from neutrinoless double-beta decay and find that predictions for mixing angles and all phases are accessible to experiments in the near future.
Sanger, T D
2003-11-01
Clinical experience suggests an important role of the indirect basal ganglia pathway in the genesis of childhood onset generalised dystonia, but it has been difficult to reconcile the increased muscle activity in dystonia with the current model of basal ganglia function in which the indirect pathway is considered primarily inhibitory. The aim of this study was to present a modification of the direct-indirect pathway model, in which the indirect pathway is inverting rather than purely inhibitory, so that while high signals are inhibited, low signals are amplified. As the basal ganglia may be a feedback loop that modifies cortical activity, instability from excessive gain in this feedback loop could explain features of dystonia. A detailed mathematical model is provided, together with simulations of cortical cell population spiking behaviour when connected through a basal ganglia loop. The simulations show that increased gain in the indirect pathway relative to the direct pathway can lead to unstable uncontrolled synchronous oscillations in cortex and basal ganglia. This behaviour could result in dystonia. The model provides a consistent explanation for the association of dystonia with parkinsonism and disorders characterised by dopamine depletion, the ability to treat some dystonias with dopamine, the ability of neuroleptic drug treatment to cause an acute dystonic reaction treatable with anticholinergic drugs, and the ability of pallidotomy or deep brain stimulation of the internal pallidum to alleviate symptoms of generalised dystonia.
A Possible Case of Systemic Lupus Erythematosus Presenting with Generalised Oedema
Kawther T. El-Shafie
2014-10-01
Full Text Available Systemic lupus erythematosus (SLE is an autoimmune disease of unknown aetiology affecting various systems within the body. We report the case of a patient with generalised subcutaneous oedema as the only presenting feature, which led to the possible diagnosis of SLE without a specific cause. The patient presented to the Sultan Qaboos University Hospital in Muscat, Oman, in April 2013. The oedema had been present for two years before admission. Other potential causes of oedema in patients with SLE were excluded, including SLE of renal origin and SLE due to protein-losing enteropathy or drugs. This was confirmed by the patient’s normal serum albumin level and negative proteinuria. Laboratory investigations showed high levels of positive antinuclear antibodies (>1:640, positive anti-double-stranded deoxyribonucleic acid results, high levels of anti-β2-glycoprotein 1 and immunoglobulin M and low levels of both complement components 3 and 4. The oedema improved immediately in response to steroids and immunosuppressive medications. Physicians should be aware that generalised subcutaneous oedema can be the only manifestation of SLE.
Chioza, B; Osei-Lah, A; Wilkie, H; Nashef, L; McCormick, D; Asherson, P; Makoff, A J
2002-12-01
Several potassium channel genes have been implicated in epilepsy. We have investigated three such genes, KCNJ3, KCNJ6 and KCNQ2, by association studies using a broad sample of idiopathic generalised epilepsy (IGE) unselected by syndrome. One of the two single nucleotide polymorphisms (SNPs) examined in one of the inward rectifying potassium channel genes, KCNJ3, was associated with IGE by genotype (P=0.0097), while its association by allele was of borderline significance (P=0.051). Analysis of the different clinical subgroups within the IGE sample showed more significant association with the presence of absence seizures (P=0.0041) and which is still significant after correction for multiple testing. Neither SNP in the other rectifying potassium channel gene, KCNJ6, was associated with IGE or any subgroup. None of the three SNPs in the voltage-gated potassium channel gene, KCNQ2, was associated with IGE. However, one SNP was associated with epilepsy with generalised tonic clonic seizures only (P=0.016), as was an SNP approximately 56 kb distant in the closely linked nicotinic acetylcholine gene CHRNA4 (P=0.014). These two SNPs were not in linkage disequilibrium with each other, suggesting that if they are not true associations they have independently occurred by chance. Neither association remains significant after correcting for multiple testing.
Efficacy of oral afoxolaner for the treatment of canine generalised demodicosis
Beugnet, Frédéric; Halos, Lénaïg; Larsen, Diane; de Vos, Christa
2016-01-01
The efficacy of oral treatment with a chewable tablet containing afoxolaner 2.27% w/w (NexGard®, Merial) administered orally was assessed in eight dogs diagnosed with generalised demodicosis and compared with efficacy in eight dogs under treatment with a topical combination of imidacloprid/moxidectin (Advocate®, Bayer). Afoxolaner was administered at the recommended dose (at least 2.5 mg/kg) on Days 0, 14, 28 and 56. The topical combination of imidacloprid/moxidectin was given at the same intervals at the recommended concentration. Clinical examinations and deep skin scrapings were performed every month in order to evaluate the effect on mite numbers and the resolution of clinical signs. The percentage reductions of mite counts were 99.2%, 99.9% and 100% on Days 28, 56 and 84, respectively, in the afoxolaner-treated group, compared to 89.8%, 85.2% and 86.6% on Days 28, 56 and 84 in the imidacloprid/moxidectin-treated group. Skin condition of the dogs also improved significantly from Day 28 to Day 84 in the afoxolaner-treated group. Mite reductions were significantly higher on Days 28, 56 and 84 in the afoxolaner-treated group compared to the imidacloprid/moxidectin-treated group. The results of this study demonstrated that afoxolaner, given orally, was effective in treating dogs with generalised demodicosis within a two-month period. PMID:27012161
Wray, Jo; Brown, Kate; Franklin, Rodney; Cassedy, Amy; Marino, Bradley S
2014-04-01
To demonstrate the generalisability of the Pediatric Cardiac Quality of Life Inventory in the United Kingdom. Children and adolescents with heart disease were recruited from three tertiary paediatric cardiac centres in the United Kingdom and completed the Pediatric Cardiac Quality of Life Inventory. Item response option variability, total and subscale scores, patterns of correlation, and internal consistency were compared between the three sites. A total of 1537 participants--768 children/adolescents and 769 parents--were evaluated from the three sites. Patterns of item response option variability were similar and acceptable for all samples--child, adolescent, parent of child, and parent of adolescent. Internal consistency was high (0.82-0.96) for all samples from each site, and item-subscale, subscale-subscale, subscale-total, and item-total correlations were moderate to excellent for each centre. Comparisons of patterns of subscale and total score correlations between the three sites revealed no significant differences. Scores on the Pediatric Cardiac Quality of Life Inventory are generalisable in the United Kingdom, supporting the use of this measure for multi-centre studies of health-related quality of life of children and adolescents with heart disease.
Do the generalised cognitive deficits observed in schizophrenia indicate a rapidly-ageing brain?
Milan Dragovic
Full Text Available Background and Objectives: The nature and pattern of cognitive deficits (CD in schizophrenia and whether the deficits are generalised or domain specific continues to be debated vigorously. We ascertained the pattern of CD in schizophrenia using a novel statistical approach by comparing the similarity of cognitive profiles of patients and healthy individuals. Methods: In a consecutive sample of 78 patients with schizophrenia, performance on six cognitive domains (verbal memory, working memory, motor speed, processing speed, verbal fluency and executive functions was measured using the Brief Assessment of Cognition in Schizophrenia (BACS. The similarity of cognitive profile between patients and two groups of healthy controls (age-matched and older adults who were in the age group of 70-79 was evaluated using a special purpose-built macro. Results: Cognitive performance profiles in various domains of patients with schizophrenia and age-matched controls were markedly similar in shape, but differed in the overall performance, with patients performing significantly below the healthy controls. However, when the cognitive profiles of patients with schizophrenia were compared to those of older adult controls, the profiles remained similar whilst the overall difference in performance vanished. Conclusions: Cognitive deficit in schizophrenia appears to be generalised. Resemblance of cognitive profiles between patients with schizophrenia and older adult controls provides some support for the accelerated ageing hypothesis of schizophrenia.
Chazelle, Emilie; Lemogne, Cédric; Morgan, Karen; Kelleher, Cecily C; Chastang, Jean-François; Niedhammer, Isabelle
2011-11-01
Social inequalities in mental disorders have been described, but studies that explain these inequalities are lacking, especially those using diagnostic interviews. This study investigates the contribution of various explanatory factors to the association between educational level and major depression and generalised anxiety disorder in Irish men and women. The study population comprised a national random sample of 5771 women and 4207 men aged 18 or more in Ireland (SLÁN 2007 survey). Major depression and generalised anxiety disorder were measured using a standardised diagnostic interview (CIDI-SF). Four groups of explanatory factors were explored: material, psychosocial, and behavioural factors, and chronic disease. For both genders, low educational level increased the risk of both mental disorders. Material factors, especially no private health insurance, but also no car, housing tenure, insufficient food budget, and unemployment (for men), made the highest contribution (stronger for men than for women) in explaining the association between education and both mental disorders. Psychosocial (especially formal social participation, social support and marital status) and behavioural factors (smoking and physical activity for both genders, and alcohol and drug use for men) and chronic disease made low independent contributions in explaining the association between education and both mental disorders. Given the cross-sectional study design, no causal conclusion could be drawn. Targeting various material, psychosocial, and behavioural factors, as well as chronic diseases may help to reduce educational differences in depression and anxiety in the general population. Copyright © 2011 Elsevier B.V. All rights reserved.
HoxPred: automated classification of Hox proteins using combinations of generalised profiles
Leyns Luc
2007-07-01
Full Text Available Abstract Background Correct identification of individual Hox proteins is an essential basis for their study in diverse research fields. Common methods to classify Hox proteins focus on the homeodomain that characterise homeobox transcription factors. Classification is hampered by the high conservation of this short domain. Phylogenetic tree reconstruction is a widely used but time-consuming classification method. Results We have developed an automated procedure, HoxPred, that classifies Hox proteins in their groups of homology. The method relies on a discriminant analysis that classifies Hox proteins according to their scores for a combination of protein generalised profiles. 54 generalised profiles dedicated to each Hox homology group were produced de novo from a curated dataset of vertebrate Hox proteins. Several classification methods were investigated to select the most accurate discriminant functions. These functions were then incorporated into the HoxPred program. Conclusion HoxPred shows a mean accuracy of 97%. Predictions on the recently-sequenced stickleback fish proteome identified 44 Hox proteins, including HoxC1a only found so far in zebrafish. Using the Uniprot databank, we demonstrate that HoxPred can efficiently contribute to large-scale automatic annotation of Hox proteins into their paralogous groups. As orthologous group predictions show a higher risk of misclassification, they should be corroborated by additional supporting evidence. HoxPred is accessible via SOAP and Web interface http://cege.vub.ac.be/hoxpred/. Complete datasets, results and source code are available at the same site.
King, Stephen F
2014-01-01
Generalised CP transformations are the only known framework which allows to predict Majorana phases in a flavour model purely from symmetry. For the first time generalised CP transformations are investigated for an infinite series of finite groups, $\\Delta(6n^2)=(Z_n\\times Z_n)\\rtimes S_3$. In direct models the mixing angles and Dirac CP phase are solely predicted from symmetry. $\\Delta(6n^2)$ flavour symmetry provides many examples of viable predictions for mixing angles. For all groups the mixing matrix has a trimaximal middle column and the Dirac CP phase is 0 or $\\pi$. The Majorana phases are predicted from residual flavour and CP symmetries where $\\alpha_{21}$ can take several discrete values for each $n$ and the Majorana phase $\\alpha_{31}$ is a multiple of $\\pi$. We discuss constraints on the groups and CP transformations from measurements of the neutrino mixing angles and from neutrinoless double-beta decay and find that predictions for mixing angles and all phases are accessible to experiments in the...
Vezzaro, Luca; Grum, Morten
2014-01-01
An innovative and generalised approach to the integrated Real Time Control of urban drainage systems is presented. The Dynamic Overflow Risk Assessment (DORA) strategy aims to minimise the expected Combined Sewer Overflow (CSO) risk by considering (i) the water volume presently stored in the drai......An innovative and generalised approach to the integrated Real Time Control of urban drainage systems is presented. The Dynamic Overflow Risk Assessment (DORA) strategy aims to minimise the expected Combined Sewer Overflow (CSO) risk by considering (i) the water volume presently stored...... in the drainage network, (ii) the expected runoff volume (calculated by radar-based nowcast models) and – most important – (iii) the estimated uncertainty of the runoff forecasts. The inclusion of uncertainty allows for a more confident use of Real Time Control (RTC). Overflow risk is calculated by a flexible...... periods, using a simple conceptual model, is presented. Compared to a traditional local control approach, DORA contributed to reduce CSO volumes from the most sensitive points while reducing total CSO volumes discharged from the catchment. Additionally, the results show that the inclusion of forecasts...
A Generalised Fault Protection Structure Proposed for Uni-grounded Low-Voltage AC Microgrids
Bui, Duong Minh; Chen, Shi-Lin; Lien, Keng-Yu; Jiang, Jheng-Lun
2016-04-01
This paper presents three main configurations of uni-grounded low-voltage AC microgrids. Transient situations of a uni-grounded low-voltage (LV) AC microgrid (MG) are simulated through various fault tests and operation transition tests between grid-connected and islanded modes. Based on transient simulation results, available fault protection methods are proposed for main and back-up protection of a uni-grounded AC microgrid. In addition, concept of a generalised fault protection structure of uni-grounded LVAC MGs is mentioned in the paper. As a result, main contributions of the paper are: (i) definition of different uni-grounded LVAC MG configurations; (ii) analysing transient responses of a uni-grounded LVAC microgrid through line-to-line faults, line-to-ground faults, three-phase faults and a microgrid operation transition test, (iii) proposing available fault protection methods for uni-grounded microgrids, such as: non-directional or directional overcurrent protection, under/over voltage protection, differential current protection, voltage-restrained overcurrent protection, and other fault protection principles not based on phase currents and voltages (e.g. total harmonic distortion detection of currents and voltages, using sequence components of current and voltage, 3I0 or 3V0 components), and (iv) developing a generalised fault protection structure with six individual protection zones to be suitable for different uni-grounded AC MG configurations.
Ng, Benjamin; Cai, Wenju; Walsh, Kevin
2014-08-12
A positive Indian Ocean Dipole (IOD) tends to have stronger cold sea surface temperature anomalies (SSTAs) over the eastern Indian Ocean with greater impacts than warm SSTAs that occur during its negative phase. Two feedbacks have been suggested as the cause of positive IOD skewness, a positive Bjerknes feedback and a negative SST-cloud-radiation (SCR) feedback, but their relative importance is debated. Using inter-model statistics, we show that the most important process for IOD skewness is an asymmetry in the thermocline feedback, whereby SSTAs respond to thermocline depth anomalies more strongly during the positive phase than negative phase. This asymmetric thermocline feedback drives IOD skewness despite positive IODs receiving greater damping from the SCR feedback. In response to global warming, although the thermocline feedback strengthens, its asymmetry between positive and negative IODs weakens. This behaviour change explains the reduction in IOD skewness that many models display under global warming.
Outdoor and indoor benzene evaluation by GC-FID and GC-MS/MS
José A. Sousa; Domingues, Valentina F.; Rosas, Mónica S.; Ribeiro, Susana; Alvim-Ferraz, Maria da Conceição M.
2011-01-01
The evaluation of benzene in different environments such as indoor (with and without tobacco smoke), a city area, countryside, gas stations and near exhaust pipes from cars running on different types of fuels was performed. The samples were analyzed using gas chromatography (GC) with flame ionization detection (FID) and tandem mass spectrometric detection (MS/MS) (to confirm the identification of benzene in the air samples). Operating conditions for the GC-MS analysis were optimized ...
Identification and determination of (+)-sesamin in Semen Cuscutae by capillary GC and GC-MS
无
2000-01-01
(+)-Sesamin was found in Semen Cuscutae for the first time. A rapid and simple approach for the analysis of (+)-sesamin in different sources of Semen Cuscutae is proposed, which used GC-FID for the determination of (+)-sesamin and GC-MS for its identification. The result suggested that this approach could be used to identify Semen Cuscutae from various sources based on the different content of (+)-sesamin in them.
Godler, David E; Inaba, Yoshimi; Schwartz, Charles E; Bui, Quang M; Shi, Elva Z; Li, Xin; Herlihy, Amy S; Skinner, Cindy; Hagerman, Randi J; Francis, David; Amor, David J; Metcalfe, Sylvia A; Hopper, John L; Slater, Howard R
2015-07-01
Methylation of the fragile X mental retardation 1 (FMR1) exon 1/intron 1 boundary positioned fragile X related epigenetic element 2 (FREE2), reveals skewed X-chromosome inactivation (XCI) in fragile X syndrome full mutation (FM: CGG > 200) females. XCI skewing has been also linked to abnormal X-linked gene expression with the broader clinical impact for sex chromosome aneuploidies (SCAs). In this study, 10 FREE2 CpG sites were targeted using methylation specific quantitative melt analysis (MS-QMA), including 3 sites that could not be analysed with previously used EpiTYPER system. The method was applied for detection of skewed XCI in FM females and in different types of SCA. We tested venous blood and saliva DNA collected from 107 controls (CGG chromosome test; (ii) locus-specific XCI skewing towards the hypomethylated state in FM females; and (iii) skewed XCI towards the hypermethylated state in SCA with 3 or more X chromosomes, and in 5% of the 47,XXY individuals. MS-QMA output also showed significant correlation with the EpiTYPER reference method in FM males and females (P < 0.0001) and SCAs (P < 0.05). In conclusion, we demonstrate use of MS-QMA to quantify skewed XCI in two applications with diagnostic utility.
Analysis of intra-genomic GC content homogeneity within prokaryotes
Bohlin, J; Snipen, L; Hardy, S.P.
2010-01-01
both aerobic and facultative microbes. Although an association has previously been found between mean genomic GC content and oxygen requirement, our analysis suggests that no such association exits when phylogenetic bias is accounted for. A significant association between GCVAR and mean GC content......Bacterial genomes possess varying GC content (total guanines (Gs) and cytosines (Cs) per total of the four bases within the genome) but within a given genome, GC content can vary locally along the chromosome, with some regions significantly more or less GC rich than on average. We have examined how...... the GC content varies within microbial genomes to assess whether this property can be associated with certain biological functions related to the organism's environment and phylogeny. We utilize a new quantity GCVAR, the intra-genomic GC content variability with respect to the average GC content...
Mendoza, Marco; Zavala-Río, Arturo; Santibáñez, Víctor; Reyes, Fernando
2015-10-01
In this paper, a globally stabilising PID-type control scheme with a generalised saturating structure for robot manipulators under input constraints is proposed. It gives rise to various families of bounded PID-type controllers whose implementation is released from the exact knowledge of the system parameters and model structure. Compared to previous approaches of the kind, the proposed scheme is not only characterised by its generalised structure but also by its very simple tuning criterion, the simplest hitherto obtained in the considered analytical framework. Experimental results on a 3-degree-of-freedom direct-drive manipulator corroborate the efficiency of the proposed approach.
Statistical Extremes of Turbulence and a Cascade Generalisation of Euler's Gyroscope Equation
Tchiguirinskaia, Ioulia; Scherzer, Daniel
2016-04-01
Turbulence refers to a rather well defined hydrodynamical phenomenon uncovered by Reynolds. Nowadays, the word turbulence is used to designate the loss of order in many different geophysical fields and the related fundamental extreme variability of environmental data over a wide range of scales. Classical statistical techniques for estimating the extremes, being largely limited to statistical distributions, do not take into account the mechanisms generating such extreme variability. An alternative approaches to nonlinear variability are based on a fundamental property of the non-linear equations: scale invariance, which means that these equations are formally invariant under given scale transforms. Its specific framework is that of multifractals. In this framework extreme variability builds up scale by scale leading to non-classical statistics. Although multifractals are increasingly understood as a basic framework for handling such variability, there is still a gap between their potential and their actual use. In this presentation we discuss how to dealt with highly theoretical problems of mathematical physics together with a wide range of geophysical applications. We use Euler's gyroscope equation as a basic element in constructing a complex deterministic system that preserves not only the scale symmetry of the Navier-Stokes equations, but some more of their symmetries. Euler's equation has been not only the object of many theoretical investigations of the gyroscope device, but also generalised enough to become the basic equation of fluid mechanics. Therefore, there is no surprise that a cascade generalisation of this equation can be used to characterise the intermittency of turbulence, to better understand the links between the multifractal exponents and the structure of a simplified, but not simplistic, version of the Navier-Stokes equations. In a given way, this approach is similar to that of Lorenz, who studied how the flap of a butterfly wing could generate
Modern methods of sample preparation for GC analysis
de Koning; Janssen, H.-G.; Brinkman, U.A.T.
2009-01-01
Today, a wide variety of techniques is available for the preparation of (semi-) solid, liquid and gaseous samples, prior to their instrumental analysis by means of capillary gas chromatography (GC) or, increasingly, comprehensive two-dimensional GC (GC × GC). In the past two decades, a large number of ‘modern’ sample-preparation techniques has been introduced, which have partly superseded their ‘classical’ counterparts. These novel techniques include off-line and on-line (sometimes semi- or f...
Self-alignment of full skewed RSINS:observability analysis and full-observable Kalman filter
Lailiang Song; Chunxi Zhang; Jiazhen Lu
2014-01-01
Traditional orthogonal strapdown inertial navigation sys-tem (SINS) cannot achieve satisfactory self-alignment accuracy in the stationary base: taking more than 5 minutes and al the iner-tial sensors biases cannot get ful observability except the up-axis accelerometer. However, the ful skewed redundant SINS (RSINS) can not only enhance the reliability of the system, but also improve the accuracy of the system, such as the initial alignment. Firstly, the observability of the system state includes attitude errors and al the inertial sensors biases are analyzed with the global perspective method: any three gyroscopes and three accelerometers can be assembled into an independent subordinate SINS (sub-SINS);the system state can be uniquely confirmed by the coupling connec-tions of al the sub-SINSs;the attitude errors and random constant biases of al the inertial sensors are observable. However, the ran-dom noises of the inertial sensors are not taken into account in the above analyzing process. Secondly, the ful-observable Kalman filter which can be applied to the actual RSINS containing random noises is established; the system state includes the position, ve-locity, attitude errors of al the sub-SINSs and the random constant biases of the redundant inertial sensors. At last, the initial self-alignment process of a typical four-redundancy ful skewed RSINS is simulated: the horizontal attitudes (pitch, rol ) errors and yaw error can be exactly evaluated within 80 s and 100 s respectively, while the random constant biases of gyroscopes and accelero-meters can be precisely evaluated within 120 s. For the ful skewed RSINS, the self-alignment accuracy is greatly improved, mean-while the self-alignment time is widely shortened.
Overcoming the effects of differential skewness of test items in scale construction
Johann M. Schepers
2004-10-01
Full Text Available The principal objective of the study was to develop a procedure for overcoming the effects of differential skewness of test items in scale construction. It was shown that the degree of skewness of test items places an upper limit on the correlations between the items, regardless of the contents of the items. If the items are ordered in terms of skewness the resulting inter correlation matrix forms a simplex or a pseudo simplex. Factoring such a matrix results in a multiplicity of factors, most of which are artifacts. A procedure for overcoming this problem was demonstrated with items from the Locus of Control Inventory (Schepers, 1995. The analysis was based on a sample of 1662 first year university students. Opsomming Die hoofdoel van die studie was om ’n prosedure te ontwikkel om die gevolge van differensiële skeefheid van toetsitems, in skaalkonstruksie, teen te werk. Daar is getoon dat die graad van skeefheid van toetsitems ’n boonste grens plaas op die korrelasies tussen die items ongeag die inhoud daarvan. Indien die items gerangskik word volgens graad van skeefheid, sal die interkorrelasiematriks van die items ’n simpleks of pseudosimpleks vorm. Indien so ’n matriks aan faktorontleding onderwerp word, lei dit tot ’n veelheid van faktore waarvan die meerderheid artefakte is. ’n Prosedure om hierdie probleem te bowe te kom, is gedemonstreer met behulp van die items van die Lokus van Beheer-vraelys (Schepers, 1995. Die ontledings is op ’n steekproef van 1662 eerstejaaruniversiteitstudente gebaseer.
Testing gravity on large scales. The skewness of the galaxy distribution at z~1
Marinoni, C; Cappi, A; Le Fèvre, O; Mazure, A; Meneux, B; Pollo, A; Iovino, A; McCracken, H J; Scaramella, R; De la Torre, S; Virey, J M; Bottini, D; Garilli, B; Le Brun, V; MacCagni, D; Picat, J P; Scodeggio, M; Tresse, L; Vettolani, G; Zanichelli, A; Adami, C; Arnouts, S; Bardelli, S; Bolzonella, M; Charlot, S; Ciliegi, P; Contini, T; Foucaud, S; Franzetti, P; Gavignaud, I; Ilbert, O; Lamareille, F; Marano, B; Mathez, G; Merighi, R; Paltani, S; Pellò, R; Pozzetti, L; Radovich, M; Vergani, D; Zamorani, G; Zucca, E; Abbas, U; Bondi, M; Bongiorno, A; Brinchmann, J; Buzzi, A; Cucciati, O; de Ravel, L; Gregorini, L; Mellier, Y; Merluzzi, P; Pérez-Montero, E; Taxil, P; Temporin, S; Walcher, C J
2008-01-01
We study the evolution of the low-order moments of the galaxy overdensity distribution over the redshift interval 0.7
Acampora, Antonio; Macdonald, J.H.G.; Georgakis, Christos T.;
2012-01-01
Despite much research in recent years, large amplitude vibrations of inclined bridge cables continue to be of concern. Various mechanisms for the excitation have been suggested, including rain-wind excitation, dry inclined cable galloping, high reduced-velocity vortex shedding and excitation from...... of this paper is to identify the aeroelastic forces for in-plane and out-of-plane vibrations of bridge cables in dry conditions as in [2], but now for skewed winds. To achieve this, an output-only system identification employing the Eigenvalue Realisation Algorithm (ERA) [3] has been applied to selected...
Rings of skew polynomials and Gel'fand-Kirillov conjecture for quantum groups
Iohara, Kenji; Malikov, Feodor
1993-01-01
We introduce and study action of quantum groups on skew polynomial rings and related rings of quotients. This leads to a ``q-deformation'' of the Gel'fand-Kirillov conjecture which we partially prove. We propose a construction of automorphisms of certain non-commutaive rings of quotients coming from complex powers of quantum group generators; this is applied to explicit calculation of singular vectors in Verma modules over $U_{q}(\\gtsl_{n+1})$. We finally give a definition of a $q-$connection...
Option-Based Estimation of the Price of Co-Skewness and Co-Kurtosis Risk
Christoffersen, Peter; Fournier, Mathieu; Fournier, Mathieu;
-neutral second moments, and the price of co-kurtosis risk corresponds to the spread between the physical and the risk-neutral third moments. The option-based estimates of the prices of risk lead to reasonable values of the associated risk premia. An out-of-sample analysis of factor models with co-skewness and co......-kurtosis risk indicates that the new estimates of the price of risk improve the models performance. Models with higher-order market moments also robustly outperform standard competitors such as the CAPM and the Fama-French model....
Option-Based Estimation of the Price of Co-Skewness and Co-Kurtosis Risk
Christoffersen, Peter; Fournier, Mathieu; Jacobs, Kris;
-neutral second moments, and the price of co-kurtosis risk corresponds to the spread between the physical and the risk-neutral third moments. The option-based estimates of the prices of risk lead to reasonable values of the associated risk premia. An out-of-sample analysis of factor models with co-skewness and co......-kurtosis risk indicates that the new estimates of the price of risk improve the models' performance. Models with higher-order market moments also robustly outperform standard competitors such as the CAPM and the Fama-French model....