WorldWideScience

Sample records for general label requirements

  1. 21 CFR 606.120 - Labeling, general requirements.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 7 2010-04-01 2010-04-01 false Labeling, general requirements. 606.120 Section 606.120 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) BIOLOGICS CURRENT GOOD MANUFACTURING PRACTICE FOR BLOOD AND BLOOD COMPONENTS Finished Product Control § 606.120 Labeling, general requirements....

  2. Map labeling and its generalizations

    Energy Technology Data Exchange (ETDEWEB)

    Doddi, S. [New Mexico Univ., Albuquerque, NM (United States). Dept. of Computer Science]|[Los Alamos National Lab., NM (United States); Marathe, M.V. [Los Alamos National Lab., NM (United States); Mirzaian, A. [York Univ., Toronto, ON (Canada). Dept. of Computer Science; Moret, B.M.E. [New Mexico Univ., Albuquerque, NM (United States). Dept. of Computer Science; Zhu, B. [City Univ. of Hong Kong (Hong Kong). Dept. of Computer Science]|[Los Alamos National Lab., NM (United States)

    1997-01-01

    Map labeling is of fundamental importance in cartography and geographical information systems and is one of the areas targeted for research by the ACM Computational Geometry Impact Task Force. Previous work on map labeling has focused on the problem of placing maximal uniform, axis-aligned, disjoint rectangles on the plane so that each point feature to be labeled lies at the corner of one rectangle. Here, we consider a number of variants of the map labeling problem. We obtain three general types of results. First, we devise constant-factor polynomial-time-approximation algorithms for labeling point features by rectangular labels, where the feature may lie anywhere on the boundary of its label region and where labeling rectangles may be placed in any orientation. These results generalize to the case of elliptical labels. Secondly, we consider the problem of labeling a map consisting of disjoint rectilinear fine segments. We obtain constant-factor polynomial-time approximation algorithms for the general problem and an optimal algorithm for the special case where all segments are horizontal. Finally, we formulate a bicriteria version of the map-labeling problem and provide bicriteria polynomial- time approximation schemes for a number of such problems.

  3. GEO label: The General Framework for Labeling and Certification

    Science.gov (United States)

    Bye, B. L.; McCallum, I.; Maso, J.

    2012-04-01

    The Group on Earth Observations (GEO) is coordinating efforts to build a Global Earth Observation System of Systems, or GEOSS. As part of a strategy to increase the involvement of the science and technology community in GEOSS, both as users and developers of GEOSS itself, GEO decided to develop a GEO label concept related to the scientific relevance, quality, acceptance and societal needs for services and data sets of GEOSS. The development of a GEO label is included in the GEO work plan and several projects address the challenges of developing a GEO label concept. Within the different projects developing the GEO label, various perspectives and approaches are being applied. In order to arrive at a generally accepted GEO label concept, a common understanding and basic knowledge of labeling is necessary. Assessment of quality of internationally standardized Earth observation data products implies possible certification. A general understanding of the framework for international standards and certification will also contribute to a more coherent discussion and more efficient development of a GEO label. We will describe the general labeling and certification framework emphasizing the relation to the three elements of the GEO label: quality, user acceptance and relevance. Based on a survey of international labels done by the EGIDA project, we have analyzed the legal framework and organization of labels and certification. We will discuss the frameworks for certification, user ratings, registration and analysis of user requirements. Quality assessment is a particular focus of the analysis and is based on the work done by the GeoViQua project. A GEO label will function both as a data distribution strategy and as a general management system for data. Through a label users can compare different data sets and get access to more information about the relevant data, including quality. A label will provide traceability of data both in the interest of users as well as data

  4. 16 CFR 1209.9 - Labeling requirement.

    Science.gov (United States)

    2010-01-01

    ... SAFETY STANDARD FOR CELLULOSE INSULATION The Standard § 1209.9 Labeling requirement. (a) Manufacturers, importers, and private labelers of cellulose insulation shall place on all containers of cellulose... corrosiveness of cellulose insulation. To meet this requirement manufacturers, importers, and private labelers...

  5. ANTIMAGIC LABELING OF GENERALIZED SAUSAGE GRAPHS

    Directory of Open Access Journals (Sweden)

    Oudone Phanalasy

    2014-10-01

    Full Text Available An antimagic labeling of a graph with q edges is a bijection from the set of edges to the set of positive integers {1,2,...,q} such that all vertex weights are pairwise distinct, where the vertex weight of a vertex is the sum of the labels of all the edges incident with that vertex. A graph is antimagic if it has an antimagic labeling. In this paper we construct antimagic labeling for the family of generalized sausage graphs.

  6. 16 CFR 300.14 - Substitute label requirement.

    Science.gov (United States)

    2010-01-01

    ... AND REGULATIONS UNDER THE WOOL PRODUCTS LABELING ACT OF 1939 Labeling § 300.14 Substitute label... 16 Commercial Practices 1 2010-01-01 2010-01-01 false Substitute label requirement. 300.14 Section... product appearing on the stamp, tag, label, or other mark of identification affixed to such product shall...

  7. General Compact Labeling Schemes for Dynamic Trees

    OpenAIRE

    2006-01-01

    Let $F$ be a function on pairs of vertices. An {\\em $F$- labeling scheme} is composed of a {\\em marker} algorithm for labeling the vertices of a graph with short labels, coupled with a {\\em decoder} algorithm allowing one to compute $F(u,v)$ of any two vertices $u$ and $v$ directly from their labels. As applications for labeling schemes concern mainly large and dynamically changing networks, it is of interest to study {\\em distributed dynamic} labeling schemes. This paper investigates labelin...

  8. 30 CFR 47.41 - Requirement for container labels.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Requirement for container labels. 47.41 Section... TRAINING HAZARD COMMUNICATION (HazCom) Container Labels and Other Forms of Warning § 47.41 Requirement for container labels. (a) The operator must ensure that each container of a hazardous chemical has a label. If...

  9. China Cotton label to be generalized

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    "China Cotton"authorization press conference was held in Beijing on October 11. China Cotton Association granted authorization to the first four enterprises, allowing them to use the label of China Cotton on their qualified products. Shandong Lanyan Group, Beijing Miantian Textile Co., Ltd are among the fi rst companies authorized to use China Cotton label.

  10. The Role of Linguistic Labels in Inductive Generalization

    Science.gov (United States)

    Deng, W.; Sloutsky, Vladimir M.

    2013-01-01

    What is the role of linguistic labels in inductive generalization? According to one approach labels denote categories and differ from object features, whereas according to another approach labels start out as features and may become category markers in the course of development. This issue was addressed in four experiments with 4- and 5-year-olds…

  11. 21 CFR 70.25 - Labeling requirements for color additives (other than hair dyes).

    Science.gov (United States)

    2010-04-01

    ... color additives (other than hair dyes). (a) General labeling requirements. All color additives shall be... 21 Food and Drugs 1 2010-04-01 2010-04-01 false Labeling requirements for color additives (other than hair dyes). 70.25 Section 70.25 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH...

  12. 77 FR 75400 - Labeling Requirements for Commercial and Industrial Equipment

    Science.gov (United States)

    2012-12-20

    ...; ] DEPARTMENT OF ENERGY 10 CFR Part 431 RIN 1904-AC84 Labeling Requirements for Commercial and Industrial... conservation standards for certain commercial and industrial equipment, and requires the Department of Energy... potential for establishing labeling requirements for covered commercial and industrial equipment,...

  13. 16 CFR 1500.125 - Labeling requirements for accompanying literature.

    Science.gov (United States)

    2010-01-01

    ... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Labeling requirements for accompanying literature. 1500.125 Section 1500.125 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION FEDERAL... REGULATIONS § 1500.125 Labeling requirements for accompanying literature. When any accompanying...

  14. 9 CFR 317.2 - Labels: definition; required features.

    Science.gov (United States)

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Labels: definition; required features. 317.2 Section 317.2 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF... labeling shall appear thereon in the English language: Provided, however, That in the case of products...

  15. General lighting requirements for photosynthesis

    Science.gov (United States)

    Geiger, Donald R.

    1994-01-01

    This paper presents data that suggests some criteria for evaluating growth chamber and greenhouse lighting. A review of the general lighting requirements for photosynthesis reveals that four aspects of light are important: irradiance, quality, timing, and duration. Effective lighting should produce plants that perform according to the goals of the project. For example, for physiological studies the plants probably should exhibit morphology and physiology similar to that found in field-grown plants. For other projects the criteria will obviously be set according to the reason for raising the plants.

  16. 40 CFR 156.10 - Labeling requirements.

    Science.gov (United States)

    2010-07-01

    ... pest. (vi) The method of application, including instructions for dilution, if required, and type(s) of... phrase as “when used as directed”; and (x) Non-numerical and/or comparative statements on the safety of... formulators on the composition, toxicity, methods of use, applicable restrictions or limitations,...

  17. Odd-graceful labeling algorithm and its implementation of generalized ring core network

    Science.gov (United States)

    Xie, Jianmin; Hong, Wenmei; Zhao, Tinggang; Yao, Bing

    2017-08-01

    The computer implementation of some labeling algorithms of special networks has practical guiding significance to computer communication network system design of functional, reliability, low communication cost. Generalized ring core network is a very important hybrid network topology structure and it is the basis of generalized ring network. In this paper, based on the requirements of research of generalized ring network addressing, the author has designed the odd-graceful labeling algorithm of generalized ring core network when n1, n2,…nm ≡ 0(mod 4), proved odd-graceful of the structure, worked out the corresponding software, and shown the practical effectiveness of this algorithm with our experimental data.

  18. 76 FR 9231 - New Customs Declarations Label Requirements

    Science.gov (United States)

    2011-02-17

    ... 111 New Customs Declarations Label Requirements AGENCY: Postal Service\\TM\\. ACTION: Final rule..., Domestic Mail Manual (DMM ) 608.2.4 to require all mailpieces containing goods that enter the Customs Territory of the United States (CTUS), from outside the CTUS, to bear a customs declaration...

  19. 21 CFR 610.68 - Exceptions or alternatives to labeling requirements for biological products held by the Strategic...

    Science.gov (United States)

    2010-04-01

    ... requirements for biological products held by the Strategic National Stockpile. 610.68 Section 610.68 Food and... GENERAL BIOLOGICAL PRODUCTS STANDARDS Labeling Standards § 610.68 Exceptions or alternatives to labeling requirements for biological products held by the Strategic National Stockpile. (a) The appropriate FDA...

  20. 46 CFR 182.410 - General requirements.

    Science.gov (United States)

    2010-10-01

    ...) MACHINERY INSTALLATION Specific Machinery Requirements § 182.410 General requirements. (a) Starting motors.... Electrical equipment in spaces, compartments, or enclosures that contain machinery powered by, or fuel...

  1. 40 CFR 59.103 - Container labeling requirements.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 5 2010-07-01 2010-07-01 false Container labeling requirements. 59.103... National Volatile Organic Compound Emission Standards for Automobile Refinish Coatings § 59.103 Container... automobile refinish coating or coating component container or package, the day, month, and year on which...

  2. 40 CFR 59.405 - Container labeling requirements.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 5 2010-07-01 2010-07-01 false Container labeling requirements. 59.405... National Volatile Organic Compound Emission Standards for Architectural Coatings § 59.405 Container... section on the coating container in which the coating is sold or distributed. (1) The date the coating...

  3. A generalized GPU-based connected component labeling algorithm

    CERN Document Server

    Komura, Yukihiro

    2016-01-01

    We propose a generalized GPU-based connected component labeling (CCL) algorithm that can be applied to both various lattices and to non-lattice environments in a uniform fashion. We extend our recent GPU-based CCL algorithm without the use of conventional iteration to the generalized method. As an application of this algorithm, we deal with the bond percolation problem. We investigate bond percolation on the honeycomb and triangle lattices to confirm the correctness of this algorithm. Moreover, we deal with bond percolation on the Bethe lattice as a substitute for a network structure, and demonstrate the performance of this algorithm on those lattices.

  4. 7 CFR 1942.117 - General requirements.

    Science.gov (United States)

    2010-01-01

    ... § 1942.117 General requirements. (a) Reserve requirements. Loans under this subpart are subject to the... 7 Agriculture 13 2010-01-01 2009-01-01 true General requirements. 1942.117 Section 1942.117 Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE, RURAL BUSINESS...

  5. 42 CFR 422.100 - General requirements.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false General requirements. 422.100 Section 422.100... General requirements. (a) Basic rule. Subject to the conditions and limitations set forth in this subpart... services. (g) Benefits affecting screening mammography, influenza vaccine, and pneumoccal vaccine....

  6. 40 CFR 87.3 - General requirements.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 20 2010-07-01 2010-07-01 false General requirements. 87.3 Section 87.3 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CONTROL OF AIR POLLUTION FROM AIRCRAFT AND AIRCRAFT ENGINES General Provisions § 87.3 General...

  7. 49 CFR 383.110 - General requirement.

    Science.gov (United States)

    2010-10-01

    ... STANDARDS; REQUIREMENTS AND PENALTIES Required Knowledge and Skills § 383.110 General requirement. All drivers of commercial motor vehicles shall have knowledge and skills necessary to operate a commercial... may wish to include in the knowledge and skills tests that it administers to CDL applicants...

  8. 21 CFR 111.410 - What requirements apply to packaging and labels?

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 2 2010-04-01 2010-04-01 false What requirements apply to packaging and labels..., PACKAGING, LABELING, OR HOLDING OPERATIONS FOR DIETARY SUPPLEMENTS Production and Process Control System: Requirements for Packaging and Labeling Operations § 111.410 What requirements apply to packaging and...

  9. 76 FR 49772 - Guidance for Industry: Bar Code Label Requirements-Questions and Answers; Availability

    Science.gov (United States)

    2011-08-11

    ... HUMAN SERVICES Food and Drug Administration Guidance for Industry: Bar Code Label Requirements... Industry: Bar Code Label Requirements--Questions and Answers'' dated August 2011. The guidance announced in... finalizes the draft guidance entitled ``Guidance for Industry: Bar Code Label Requirements--Questions and...

  10. 21 CFR 640.93 - General requirements.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 7 2010-04-01 2010-04-01 false General requirements. 640.93 Section 640.93 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) BIOLOGICS... requirements. (a) Preservative. The final product shall not contain a preservative. (b) Storage of...

  11. 40 CFR 141.80 - General requirements.

    Science.gov (United States)

    2010-07-01

    ... exceeding the lead or copper action level shall implement all applicable source water treatment requirements...) NATIONAL PRIMARY DRINKING WATER REGULATIONS Control of Lead and Copper § 141.80 General requirements. (a... drinking water regulations for lead and copper. Unless otherwise indicated, each of the provisions of...

  12. 40 CFR 85.1510 - Maintenance instructions, warranties, emission labeling and fuel economy requirements.

    Science.gov (United States)

    2010-07-01

    ..., emission labeling and fuel economy requirements. 85.1510 Section 85.1510 Protection of Environment..., warranties, emission labeling and fuel economy requirements. The provisions of this section are applicable to... for final admission. (d) Fuel economy labeling. (1) The certificate holder shall affix a fuel...

  13. 27 CFR 4.38 - General requirements.

    Science.gov (United States)

    2010-04-01

    ... shall not be set off with a border or otherwise accentuated. (c) English language. All mandatory label information shall be stated on labels in the English language, except that the brand name, the place of... label need not be in the English language if the words “product of” immediately precede the name of...

  14. 21 CFR 201.56 - Requirements on content and format of labeling for human prescription drug and biological products.

    Science.gov (United States)

    2010-04-01

    ... human prescription drug and biological products. 201.56 Section 201.56 Food and Drugs FOOD AND DRUG... human prescription drug and biological products. (a) General requirements. Prescription drug labeling... requirements in §§ 201.56(d) and 201.57. (1) The following categories of prescription drug products are...

  15. 16 CFR 1209.3 - General requirements.

    Science.gov (United States)

    2010-01-01

    ... SAFETY STANDARD FOR CELLULOSE INSULATION The Standard § 1209.3 General requirements. (a) All cellulose... observed over a 40-W appliance light bulb. (b) All cellulose insulation to which this interim standard...) All cellulose insulation to which this interim standard applies, as described in § 1209.1, shall have...

  16. 21 CFR 640.83 - General requirements.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 7 2010-04-01 2010-04-01 false General requirements. 640.83 Section 640.83 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) BIOLOGICS...) Preservative. The final product shall not contain a preservative. (b) Storage of bulk solution. After...

  17. 21 CFR 640.101 - General requirements.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 7 2010-04-01 2010-04-01 false General requirements. 640.101 Section 640.101 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) BIOLOGICS... not show any visible sign of gelation after heating in a 12 x 75 mm. stoppered glass tube at 57 °C for...

  18. 49 CFR 387.403 - General requirements.

    Science.gov (United States)

    2010-10-01

    ... RESPONSIBILITY FOR MOTOR CARRIERS Surety Bonds and Policies of Insurance for Freight Forwarders § 387.403 General requirements. Link to an amendment published at 75 FR 35328, June 22, 2010. (a) Cargo. A freight forwarder... case of freight vehicles described at 49 CFR 387.303(b)(2), for environmental restoration, resulting...

  19. 16 CFR 1101.31 - General requirements.

    Science.gov (United States)

    2010-01-01

    ... 16 Commercial Practices 2 2010-01-01 2010-01-01 false General requirements. 1101.31 Section 1101.31 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION CONSUMER PRODUCT SAFETY ACT REGULATIONS INFORMATION DISCLOSURE UNDER SECTION 6(b) OF THE CONSUMER PRODUCT SAFETY ACT Reasonable Steps Commission Will Take To Assure Information It Discloses...

  20. 7 CFR 322.22 - General requirements.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 5 2010-01-01 2010-01-01 false General requirements. 322.22 Section 322.22 Agriculture Regulations of the Department of Agriculture (Continued) ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE BEES, BEEKEEPING BYPRODUCTS, AND BEEKEEPING EQUIPMENT Transit...

  1. 7 CFR 322.5 - General requirements.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 5 2010-01-01 2010-01-01 false General requirements. 322.5 Section 322.5 Agriculture Regulations of the Department of Agriculture (Continued) ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE BEES, BEEKEEPING BYPRODUCTS, AND BEEKEEPING EQUIPMENT Importation of...

  2. 29 CFR 1910.132 - General requirements.

    Science.gov (United States)

    2010-07-01

    ... protective footwear (including steel-toe shoes or steel-toe boots) and non-specialty prescription safety... Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR OCCUPATIONAL SAFETY AND HEALTH STANDARDS Personal Protective Equipment § 1910.132 General requirements....

  3. 19 CFR 146.21 - General requirements.

    Science.gov (United States)

    2010-04-01

    ... TREASURY (CONTINUED) FOREIGN TRADE ZONES Inventory Control and Recordkeeping System § 146.21 General requirements. (a) Systems capability. The operator shall maintain either manual or automated inventory control and recordkeeping systems or combination manual and automated systems capable of: (1) Accounting...

  4. 29 CFR 1926.300 - General requirements.

    Science.gov (United States)

    2010-07-01

    ... Institute, B15.1-1953 (R1958), Safety Code for Mechanical Power-Transmission Apparatus. (3) Types of... (CONTINUED) SAFETY AND HEALTH REGULATIONS FOR CONSTRUCTION Tools-Hand and Power § 1926.300 General requirements. (a) Condition of tools. All hand and power tools and similar equipment, whether furnished by...

  5. 36 CFR 72.30 - General requirements.

    Science.gov (United States)

    2010-07-01

    ... Section 72.30 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR URBAN... and Innovation § 72.30 General requirements. Applicants must have an approved Recovery Action Program on file with the appropriate NPS Regional Office prior to applying for Rehabilitation or Innovation...

  6. 7 CFR 81.5 - General requirements.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false General requirements. 81.5 Section 81.5 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) EXPORT AND DOMESTIC...

  7. 21 CFR 701.2 - Form of stating labeling requirements.

    Science.gov (United States)

    2010-04-01

    ... labeling shall appear thereon in the English language: Provided, however, That in the case of articles distributed solely in the Commonwealth of Puerto Rico or in a Territory where the predominant language is one other than English, the predominant language may be substituted for English. (2) If the label...

  8. A general approach to visualize protein binding and DNA conformation without protein labelling.

    Science.gov (United States)

    Song, Dan; Graham, Thomas G W; Loparo, Joseph J

    2016-01-01

    Single-molecule manipulation methods, such as magnetic tweezers and flow stretching, generally use the measurement of changes in DNA extension as a proxy for examining interactions between a DNA-binding protein and its substrate. These approaches are unable to directly measure protein-DNA association without fluorescently labelling the protein, which can be challenging. Here we address this limitation by developing a new approach that visualizes unlabelled protein binding on DNA with changes in DNA conformation in a relatively high-throughput manner. Protein binding to DNA molecules sparsely labelled with Cy3 results in an increase in fluorescence intensity due to protein-induced fluorescence enhancement (PIFE), whereas DNA length is monitored under flow of buffer through a microfluidic flow cell. Given that our assay uses unlabelled protein, it is not limited to the low protein concentrations normally required for single-molecule fluorescence imaging and should be broadly applicable to studying protein-DNA interactions.

  9. 40 CFR 600.307-86 - Fuel economy label format requirements.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 29 2010-07-01 2010-07-01 false Fuel economy label format requirements...) ENERGY POLICY FUEL ECONOMY AND CARBON-RELATED EXHAUST EMISSIONS OF MOTOR VEHICLES Fuel Economy Regulations for 1977 and Later Model Year Automobiles-Labeling § 600.307-86 Fuel economy label format...

  10. 10 CFR 835.606 - Exceptions to labeling requirements.

    Science.gov (United States)

    2010-01-01

    ... equipment, such as reactor components, piping, and tanks; or (6) The radioactive material consists solely of nuclear weapons or their components. (b) Radioactive material labels applied to sealed radioactive...

  11. Classification & Labelling Inventory: role of ECHA and notification requirements

    Directory of Open Access Journals (Sweden)

    Gabriele Schöning

    2011-01-01

    Full Text Available The CLP Regulation introduces the criteria of the UN Globally Harmonised System of Classification and Labelling (UN GHS in the EU. The European Chemicals Agency (ECHA manages the CLP related tasks - such as harmonised classification and labelling, handling requests for alternative names and maintaining the Classification & Labelling Inventory (C&L - to ensure consistent implementation in the EU. The obligations for industry depend on their role in the supply chain. Manufacturers and importers have to notify to ECHA the identity and classification and labelling of substances within one month of placing them on the market either on their own or in a mixture, and regardless of the quantitity. As of 3 January 2011 ECHA has received some 3.1 million notifications of over 107 000 substances. This information is stored in the C&L Inventory and accessible to Member State Competent Authorities. The non-confidential information will be made publicly available on ECHA's website in 2011.

  12. REQUIREMENTS FOR A GENERAL INTERPRETATION THEORY

    Directory of Open Access Journals (Sweden)

    Anda Laura Lungu Petruescu

    2013-06-01

    Full Text Available Time has proved that Economic Analysis is not enough as to ensure all the needs of the economic field. The present study wishes to propose a new approach method of the economic phenomena and processes based on the researches made outside the economic space- a new general interpretation theory- which is centered on the human being as the basic actor of economy. A general interpretation theory must assure the interpretation of the causalities among the economic phenomena and processes- causal interpretation; the interpretation of the correlations and dependencies among indicators- normative interpretation; the interpretation of social and communicational processes in economic organizations- social and communicational interpretation; the interpretation of the community status of companies- transsocial interpretation; the interpretation of the purposes of human activities and their coherency – teleological interpretation; the interpretation of equilibrium/ disequilibrium from inside the economic systems- optimality interpretation. In order to respond to such demands, rigor, pragmatism, praxiology and contextual connectors are required. In order to progress, the economic science must improve its language, both its syntax and its semantics. The clarity of exposure requires a language clarity and the scientific theory progress asks for the need of hypotheses in the building of the theories. The switch from the common language to the symbolic one means the switch from ambiguity to rigor and rationality, that is order in thinking. But order implies structure, which implies formalization. Our paper should be a plea for these requirements, requirements which should be fulfilled by a modern interpretation theory.

  13. Overview of Medical food with specific emphasis of its labeling requirements in US and Australia

    Directory of Open Access Journals (Sweden)

    Mansi kavi

    2015-01-01

    Full Text Available Purpose: A food that are specially formulated and intended for the dietary management of a disease that has distinctive nutritional needs that cannot be met by normal diet alone is known as medical food. Medical food is newly developed products for mostly genetic disease and have advantage over allopathic medicines as they have lesser side effects and easily acceptable by patients. Now a days Medical food is growing industry and have a wide opportunity in pharmaceutical industry because of low cost compare to allopathic medicines as it do not require premarket approval. It is also known as alternative medicines. Method: In different countries medical food is regulated under different name like in US it is regulated under Medical food while in Australia it is regulated under name of food for special dietary use. Medical food must meet distinctive nutritional requirement for particular disease state and administered under the supervision of physician and contain ingredient that are generally consider as a safe as per GRAS (generally recognized as safe. Medical food regulation is required to because it is newly developed therapy. Result and conclusion: This article includes general information of medical food, how it differ from drug and dietary supplements, its concept, general regulatory requirements, current marketing scenario and labeling requirements in US and Australia. In US medical food is regulated by FDA (food and drug administration and in Australia it is regulated by FSANZ (food standard Australia and New Zealand.

  14. 9 CFR 590.410 - Shell eggs and egg products required to be labeled.

    Science.gov (United States)

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Shell eggs and egg products required... INSPECTION ACT) Identifying and Marking Product § 590.410 Shell eggs and egg products required to be labeled. (a) All shell eggs packed into containers destined for the ultimate consumer shall be labeled...

  15. 16 CFR 1500.20 - Labeling requirement for advertising toys and games.

    Science.gov (United States)

    2010-01-01

    ... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Labeling requirement for advertising toys... REGULATIONS § 1500.20 Labeling requirement for advertising toys and games. (a) Scope. This section applies to catalogue and other printed material advertisements which provide a direct means of purchase or order...

  16. The effects of echolalia on acquisition and generalization of receptive labeling in autistic children.

    OpenAIRE

    Charlop, M H

    1983-01-01

    This investigation, consisting of two experiments, was designed to assess the effects of autistic immediate echolalia on acquisition and generalization of receptive labeling tasks. Experiment 1 addressed whether autistic children could use their echolalia to facilitate acquisition. The results indicated that incorporating echolalia (echo of the requested object's label) into the task before manual response (handing the requested object to the experimenter) facilitated receptive labeling. Expe...

  17. Frequency of ill-founded off-label prescribing in Dutch general practice.

    NARCIS (Netherlands)

    Gijsen, R.; Jochemsen, H.; Dijk, L. van; Caspers, P.

    2009-01-01

    Purpose: The aim of this study is to quantify the extent of ill-founded off-label drug prescriptions in Dutch general practice. The study is based upon information on both the prescription itself and the patient’s medical history. Methods: In total, 48 combinations of drugs and off-label indications

  18. 21 CFR 862.2050 - General purpose laboratory equipment labeled or promoted for a specific medical use.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false General purpose laboratory equipment labeled or... TOXICOLOGY DEVICES Clinical Laboratory Instruments § 862.2050 General purpose laboratory equipment labeled or promoted for a specific medical use. (a) Identification. General purpose laboratory equipment labeled...

  19. Revisions to labeling requirements for blood and blood components, including source plasma. Final rule.

    Science.gov (United States)

    2012-01-03

    The Food and Drug Administration (FDA) is revising the labeling requirements for blood and blood components intended for use in transfusion or for further manufacture by combining, simplifying, and updating specific regulations applicable to labeling and circulars of information. These requirements will facilitate the use of a labeling system using machine-readable information that would be acceptable as a replacement for the ``ABC Codabar'' system for the labeling of blood and blood components. FDA is taking this action as a part of its efforts to comprehensively review and, as necessary, revise its regulations, policies, guidances, and procedures related to the regulation of blood and blood components. This final rule is intended to help ensure the continued safety of the blood supply and facilitate consistency in labeling.

  20. Outstanding Questions In First Amendment Law Related To Food Labeling Disclosure Requirements For Health.

    Science.gov (United States)

    Pomeranz, Jennifer L

    2015-11-01

    The federal and state governments are increasingly focusing on food labeling as a method to support good health. Many such laws are opposed by the food industry and may be challenged in court, raising the question of what is legally feasible. This article analyzes outstanding questions in First Amendment law related to commercial disclosure requirements and conducts legal analysis and policy evaluation for three current policies. These include the Food and Drug Administration's draft regulation requiring an added sugar disclosure on the Nutrition Facts panel, California's proposed sugar-sweetened beverage safety warning label bill, and Vermont's law requiring labels of genetically engineered food to disclose this information. I recommend several methods for policy makers to enact food labeling laws within First Amendment parameters, including imposing factual commercial disclosure requirements, disclosing the government entity issuing a warning, collecting evidence, and identifying legitimate governmental interests. Project HOPE—The People-to-People Health Foundation, Inc.

  1. 46 CFR 111.25-1 - General requirements.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false General requirements. 111.25-1 Section 111.25-1 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) ELECTRICAL ENGINEERING ELECTRIC SYSTEMS-GENERAL REQUIREMENTS Motors § 111.25-1 General requirements. The requirements for generators contained in § 111.12-5...

  2. 50 CFR 222.301 - General requirements.

    Science.gov (United States)

    2010-10-01

    ... ADMINISTRATION, DEPARTMENT OF COMMERCE MARINE MAMMALS GENERAL ENDANGERED AND THREATENED MARINE SPECIES General... Commerce that has been determined to be endangered under the Act, or that has been determined to be... effective administration of those parts and will not be unlawful. Other sections within parts 222, 223,...

  3. 75 FR 54347 - Draft Guidance for Industry: Bar Code Label Requirements-Questions and Answers (Question 12...

    Science.gov (United States)

    2010-09-07

    ... HUMAN SERVICES Food and Drug Administration Draft Guidance for Industry: Bar Code Label Requirements... document entitled ``Guidance for Industry: Bar Code Label Requirements--Questions and Answers (Question 12... Industry: Bar Code Label Requirements--Questions and Answers (Question 12 Update)'' dated August 2010. FDA...

  4. The Effects of Echolalia on Acquisition and Generalization of Receptive Labeling in Autistic Children.

    Science.gov (United States)

    Charlop, Marjorie H.

    1983-01-01

    Two experiments, with about five autistic children (two to 14 years old) in each experiment, assessed the effects of autistic immediate echolalia on acquisition and generalization of receptive labeling tasks. These results indicated that echolalia faciliated generalization for echolalic autistic children but not for functionally mute autistic…

  5. Store Image and Private Label Brands in Zimbabwe: Relationship with General Perception, Perceived Risk and Quality

    Directory of Open Access Journals (Sweden)

    Sarah Nyengerai

    2013-06-01

    Full Text Available Private label brand market penetration is estimated at less than 8% in Southern Africa. Retailers need to develop strategies that will drive growth of the industry. A survey was conducted to quantify the effect of two store image dimensions on general private label brand perception as well as the effect of the store image dimensions on perceived risk and quality of private label brands. Data collected was analysed using simple linear regression. Results illustrated that perceived store general image as well as store layout and services had a significant (p < 0.05 and positive effect on general private label brand perception. A higher perception of store image dimensions reduced the perceived risk of purchasing private label brands and the effect was significant (p < 0.05. Store image dimensions did not have a significant effect on perceived quality of private label brands. The authors concluded that there is scope to improve PLB perception among consumers in Zimbabwe through improvements in store image dimensions. They recommended that retailers hone on store image through measures such as selling a wide selection of good quality products; the creation of a good store atmosphere and investment in the training of staff in customers care.

  6. 40 CFR 141.130 - General requirements.

    Science.gov (United States)

    2010-07-01

    ... treatment technique requirements for disinfection byproduct precursors in § 141.135. (2) The regulations in... established MCLs for TTHM and HAA5 and treatment technique requirements for disinfection byproduct precursors..., distribution line breaks, storm run-off events, source water contamination events, or cross-connection events....

  7. 40 CFR 141.70 - General requirements.

    Science.gov (United States)

    2010-07-01

    ... technique requirements in lieu of maximum contaminant levels for the following contaminants: Giardia lamblia... achieve: (1) At least 99.9 percent (3-log) removal and/or inactivation of Giardia lamblia cysts between...

  8. 49 CFR 172.402 - Additional labeling requirements.

    Science.gov (United States)

    2010-10-01

    ... for Class 1 or Class 2 materials see paragraph (e) or paragraphs (f) and (g), respectively, of this... (packing group) Subsidiary Hazard (Class or Division) 3 4.1 4.2 4.3 5.1 6.1 8 I X *** *** X X X X II X X X X X X X III * X X X X X X X—Required for all......

  9. 24 CFR 35.905 - Definitions and other general requirements.

    Science.gov (United States)

    2010-04-01

    ... Rehabilitation § 35.905 Definitions and other general requirements. Definitions and other general requirements... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Definitions and other general requirements. 35.905 Section 35.905 Housing and Urban Development Office of the Secretary, Department...

  10. 29 CFR 1926.403 - General requirements.

    Science.gov (United States)

    2010-07-01

    ... are exposed for inspection or servicing, the working space, if in a passageway or general open space... sufficient durability to withstand the environment involved. (h) Identification of disconnecting means and... sufficient durability to withstand the environment involved. (i) 600 Volts, nominal, or less. This...

  11. 36 CFR 220.4 - General requirements.

    Science.gov (United States)

    2010-07-01

    ... as the sole scoping mechanism for a proposed action. (f) Cumulative effects considerations of past... accordance with “The Council on Environmental Quality Guidance Memorandum on Consideration of Past Actions in... alternatives. CEQ regulations do not require the consideration of the individual effects of all past actions...

  12. 12 CFR 614.4200 - General requirements.

    Science.gov (United States)

    2010-01-01

    ... Banks and Banking FARM CREDIT ADMINISTRATION FARM CREDIT SYSTEM LOAN POLICIES AND OPERATIONS Loan Terms... of each loan made by a Farm Credit bank or association shall be set forth in a written document or... the requirements of 12 CFR 202.9. (b) Security. (1) Long-term real estate mortgage loans must...

  13. 29 CFR 780.604 - General requirements.

    Science.gov (United States)

    2010-07-01

    ... follows: (a) Employment of the employee “primarily” in agriculture in the particular workweek. (b) This primary employment by a farmer. (c) Engagement by the farmer in raising livestock. (d) Engagement by the... employee. These requirements will be separately discussed in the following sections of this subpart. ...

  14. 49 CFR 178.601 - General requirements.

    Science.gov (United States)

    2010-10-01

    ... sufficient quantity of absorbent material to absorb the entire liquid contents of the inner packagings; (vi... absorbent material required in paragraph (g)(2)(v) of this section must be placed inside the means of... packaging; (iv) The same type or design of absorbent materials, cushioning materials and any...

  15. 49 CFR 174.55 - General requirements.

    Science.gov (United States)

    2010-10-01

    ... cannot fall or slide and must be safeguarded in such a manner that other freight cannot fall onto or slide into it under conditions normally incident to transportation. When this protection cannot be... material unless the doors meet the design strength requirements of Specification M-930 (for...

  16. 14 CFR 1204.403 - General requirements.

    Science.gov (United States)

    2010-01-01

    ... requests for proposals to determine suitability for small participation or set-asides, unless the... office of the Small Business Administration (assigned PCR) shall be informed of proposed procurements...) In accordance with Public Law 95-507, NASA will require contractors having contracts in excess of...

  17. 40 CFR 96.170 - General requirements.

    Science.gov (United States)

    2010-07-01

    ... systems required to monitor NOX emission rate, NOX concentration, stack gas moisture content, stack gas...) For the owner or operator of a CAIR NOX unit for which construction of a new stack or flue or... first, after the date on which emissions first exit to the atmosphere through the new stack or flue...

  18. 40 CFR 96.270 - General requirements.

    Science.gov (United States)

    2010-07-01

    ... systems required to monitor SO2 concentration, stack gas moisture content, stack gas flow rate, CO2 or O2... SO2 unit for which construction of a new stack or flue or installation of add-on SO2 emission controls... emissions first exit to the atmosphere through the new stack or flue or add-on SO2 emissions controls....

  19. 28 CFR 80.6 - General requirements.

    Science.gov (United States)

    2010-07-01

    ... chief executive officer to sign the opinion request. In appropriate cases, the Department of Justice may require the chief executive officer of each requesting issuer or corporate domestic concern to sign the... Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) FOREIGN CORRUPT PRACTICES ACT OPINION...

  20. Diagnostic labelling as determinant of antibiotic prescribing for acute respiratory tract episodes in general practice

    Science.gov (United States)

    van Duijn, Huug J; Kuyvenhoven, Marijke M; Tiebosch, Hanneke M; Schellevis, François G; Verheij, Theo JM

    2007-01-01

    Background Next to other GP characteristics, diagnostic labelling (the proportion of acute respiratory tract (RT) episodes to be labelled as infections) probably contributes to a higher volume of antibiotic prescriptions for acute RT episodes. However, it is unknown whether there is an independent association between diagnostic labelling and the volume of prescribed antibiotics, or whether diagnostic labelling is associated with the number of presented acute RT episodes and consequently with the number of antibiotics prescribed per patient per year. Methods Data were used from the Second Dutch National Survey of General Practice (DNSGP-2) with 163 GPs from 85 Dutch practices, serving a population of 359,625 patients. Data over a 12 month period were analysed by means of multiple linear regression analysis. Main outcome measure was the volume of antibiotic prescriptions for acute RT episodes per 1,000 patients. Results The incidence was 236.9 acute RT episodes/1,000 patients. GPs labelled about 70% of acute RT episodes as infections, and antibiotics were prescribed in 41% of all acute RT episodes. A higher incidence of acute RT episodes (beta 0.67), a stronger inclination to label episodes as infections (beta 0.24), a stronger endorsement of the need of antibiotics in case of white spots in the throat (beta 0.11) and being male (beta 0.11) were independent determinants of the prescribed volume of antibiotics for acute RT episodes, whereas diagnostic labelling was not correlated with the incidence of acute RT episodes. Conclusion Diagnostic labelling is a relevant factor in GPs' antibiotic prescribing independent from the incidence of acute RT episodes. Therefore, quality assurance programs and postgraduate courses should emphasise to use evidence based prognostic criteria (e.g. chronic respiratory co-morbidity and old age) as an indication to prescribe antibiotics in stead of single inflammation signs or diagnostic labels. PMID:17883832

  1. Diagnostic labelling as determinant of antibiotic prescribing for acute respiratory tract episodes in general practice

    Directory of Open Access Journals (Sweden)

    Schellevis François G

    2007-09-01

    Full Text Available Abstract Background Next to other GP characteristics, diagnostic labelling (the proportion of acute respiratory tract (RT episodes to be labelled as infections probably contributes to a higher volume of antibiotic prescriptions for acute RT episodes. However, it is unknown whether there is an independent association between diagnostic labelling and the volume of prescribed antibiotics, or whether diagnostic labelling is associated with the number of presented acute RT episodes and consequently with the number of antibiotics prescribed per patient per year. Methods Data were used from the Second Dutch National Survey of General Practice (DNSGP-2 with 163 GPs from 85 Dutch practices, serving a population of 359,625 patients. Data over a 12 month period were analysed by means of multiple linear regression analysis. Main outcome measure was the volume of antibiotic prescriptions for acute RT episodes per 1,000 patients. Results The incidence was 236.9 acute RT episodes/1,000 patients. GPs labelled about 70% of acute RT episodes as infections, and antibiotics were prescribed in 41% of all acute RT episodes. A higher incidence of acute RT episodes (beta 0.67, a stronger inclination to label episodes as infections (beta 0.24, a stronger endorsement of the need of antibiotics in case of white spots in the throat (beta 0.11 and being male (beta 0.11 were independent determinants of the prescribed volume of antibiotics for acute RT episodes, whereas diagnostic labelling was not correlated with the incidence of acute RT episodes. Conclusion Diagnostic labelling is a relevant factor in GPs' antibiotic prescribing independent from the incidence of acute RT episodes. Therefore, quality assurance programs and postgraduate courses should emphasise to use evidence based prognostic criteria (e.g. chronic respiratory co-morbidity and old age as an indication to prescribe antibiotics in stead of single inflammation signs or diagnostic labels.

  2. 77 FR 7 - Revisions to Labeling Requirements for Blood and Blood Components, Including Source Plasma

    Science.gov (United States)

    2012-01-03

    ...) Revisions to Labeling Requirements for Blood and Blood Components, Including Source Plasma AGENCY: Food and... requirements for blood and blood components, including Source Plasma, into one section of the Code of Federal..., and Source Plasma,'' which amended Sec. 606.121(d)(2) by adding ``or in solid black,''...

  3. The Influence of Label Co-occurrence and Semantic Similarity on Children’s Inductive Generalization

    Directory of Open Access Journals (Sweden)

    Bryan J Matlen

    2015-08-01

    Full Text Available Semantically-similar labels that co-occur in child-directed speech (e.g., bunny-rabbit are more likely to promote inductive generalization in preschoolers than non-co-occurring labels (e.g., lamb-sheep. However, it remains unclear whether this effect stems from co-occurrence or other factors, and how co-occurrence contributes to generalization. To address these issues, preschoolers were exposed to a stream of semantically-similar labels that don’t co-occur in natural language, but were arranged to co-occur in the experimental setting. In Experiment 1, children exposed to the co-occurring stream were more likely to make category-consistent inferences than children in two control conditions. Experiment 2 replicated this effect and provided evidence that co-occurrence training influenced generalization only when the trained labels were categorically-similar. These findings suggest that both co-occurrence information and semantic representations contribute to preschool-age children’s inductive generalization. The findings are discussed in relation to the developmental accounts of inductive generalization.

  4. Development of a general methodology for labelling peptide-morpholino oligonucleotide conjugates using alkyne-azide click chemistry.

    Science.gov (United States)

    Shabanpoor, Fazel; Gait, Michael J

    2013-11-11

    We describe a general methodology for fluorescent labelling of peptide conjugates of phosphorodiamidate morpholino oligonucleotides (PMOs) by alkyne functionalization of peptides, subsequent conjugation to PMOs and labelling with a fluorescent compound (Cy5-azide). Two peptide-PMO (PPMO) examples are shown. No detrimental effect of such labelled PMOs was seen in a biological assay.

  5. 33 CFR 136.105 - General requirements for a claim.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false General requirements for a claim. 136.105 Section 136.105 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY... PROCEDURES; DESIGNATION OF SOURCE; AND ADVERTISEMENT General Procedure § 136.105 General requirements for...

  6. 47 CFR 95.1115 - General technical requirements.

    Science.gov (United States)

    2010-10-01

    ... SERVICES PERSONAL RADIO SERVICES Wireless Medical Telemetry Service (WMTS) General Provisions § 95.1115 General technical requirements. (a) Field strength limits. (1) In the 608-614 MHz band, the maximum... 47 Telecommunication 5 2010-10-01 2010-10-01 false General technical requirements. 95.1115...

  7. 7 CFR 764.104 - General real estate security requirements.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 7 2010-01-01 2010-01-01 false General real estate security requirements. 764.104....104 General real estate security requirements. (a) Agency lien position requirements. If real estate... Agency; and (4) Equity in the collateral exists. (b) Real estate held under a purchase contract. If the...

  8. 28 CFR 33.50 - General financial requirements.

    Science.gov (United States)

    2010-07-01

    ... 28 Judicial Administration 1 2010-07-01 2010-07-01 false General financial requirements. 33.50 Section 33.50 Judicial Administration DEPARTMENT OF JUSTICE BUREAU OF JUSTICE ASSISTANCE GRANT PROGRAMS Criminal Justice Block Grants Additional Requirements § 33.50 General financial requirements. Grants...

  9. 14 CFR 147.21 - General curriculum requirements.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false General curriculum requirements. 147.21... Requirements § 147.21 General curriculum requirements. (a) An applicant for an aviation maintenance technician school certificate and rating, or for an additional rating, must have an approved curriculum that is...

  10. 14 CFR 121.113 - Area and route requirements: General.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Area and route requirements: General. 121... OPERATING REQUIREMENTS: DOMESTIC, FLAG, AND SUPPLEMENTAL OPERATIONS Approval of Areas and Routes for Supplemental Operations § 121.113 Area and route requirements: General. (a) Each certificate holder...

  11. A general method for tritium labelling of benzimidazole carbamates by catalytic exchange in dioxane solutions

    Energy Technology Data Exchange (ETDEWEB)

    Lacey, E. (Commonwealth Scientific and Industrial Research Organization, Glebe, NSW (Australia). Div. of Animal Health, McMaster Lab.); Dawson, M. (Sydney Univ. (Australia). Dept. of Pharmacy); Long, M.A.; Than, C. (New South Wales Univ., Kensington (Australia). School of Chemistry)

    1989-12-01

    Benzimidazole carbamates (BZCs) act as inhibitors of the tubulin-microtubule equilibria in eukaryotic organisms. Recently drug resistance to this class of compounds in helminth parasites has been shown to be due to a reduced ability of resistant tubulin to bind BZCs. In order to quantitate the nature of the tubulin-BZC interaction a general method for the specific tritium labelling of BZCs has been developed. The BZCs: mebendazole, oxfendazole, parbendazole, oxibendazole, albendazole and fenbendazole were labelled by catalytic exchange using palladium on calcium carbonate in pure dioxane at 60{sup 0}C under tritium gas. The position of label incorporation for tritiated albendazole was determined by tritium-NMR as the 4-position of benzimadazole nucleus. The yields for individual BZCs varied from 8 to 68% for a range of specific activity of 0.44 to 13.4 Ci/mmole. (author).

  12. 16 CFR Appendix A to Part 306 - Summary of Labeling Requirements for Biodiesel Fuels

    Science.gov (United States)

    2010-01-01

    ... Biodiesel Fuels A Appendix A to Part 306 Commercial Practices FEDERAL TRADE COMMISSION REGULATIONS UNDER... Part 306—Summary of Labeling Requirements for Biodiesel Fuels (Part 1 of 2) Fuel type Blends of 5 percent or less Blends of more than 5 but not more than 20 percent Header Text Color Biodiesel No...

  13. 21 CFR 111.415 - What requirements apply to filling, assembling, packaging, labeling, and related operations?

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 2 2010-04-01 2010-04-01 false What requirements apply to filling, assembling, packaging, labeling, and related operations? 111.415 Section 111.415 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION CURRENT GOOD...

  14. 40 CFR 600.307-08 - Fuel economy label format requirements.

    Science.gov (United States)

    2010-07-01

    ... following elements: (i) A bar that represents the total range of combined fuel economy for the applicable... 40 Protection of Environment 29 2010-07-01 2010-07-01 false Fuel economy label format requirements...) ENERGY POLICY FUEL ECONOMY AND CARBON-RELATED EXHAUST EMISSIONS OF MOTOR VEHICLES Fuel...

  15. 9 CFR 317.1 - Labels required; supervision by Program employee.

    Science.gov (United States)

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Labels required; supervision by Program employee. 317.1 Section 317.1 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE... information except company brand names, trade marks, or code numbers which do not include any...

  16. A General Approach to L(h, k)-Label Interconnection Networks

    Institute of Scientific and Technical Information of China (English)

    Tiziana Calamoneri; Saverio Caminiti; Rossella Petreschi

    2008-01-01

    Given two non-negative integers h and k, an L(h, k)-labelin9 of a graph G = (V, E) is a function from the set V to a set of colors, such that adjacent nodes take colors at distance at least h, and nodes at distance 2 take colors at distanceat least k. The aim of the L(h, k)-labeling problem is to minimize the greatest used color. Since the decisional version of this problem is NP-complete, it is important to investigate particular classes of graphs for which the problem can be efficiently solved. It is well known that the most common interconnection topologies, such as Butterfly-like, Benes, CCC, Trivalent Cayley networks, are all characterized by a similar structure: they have nodes organized as a matrix and connections are divided into layers. So we naturally introduce a new class of graphs, called (l×n)-multistage graphs, containing the most common interconnection topologies, on which we study the L(h, k)-labeling. A general algorithm for L(h, k)-labeling these graphs is presented, and from this method an efficient L(2, 1)-labeling for Butterfly and CCC networks is derived. Finally we describe a possible generalization of our approach.

  17. 40 CFR 1033.110 - Emission diagnostics-general requirements.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 32 2010-07-01 2010-07-01 false Emission diagnostics-general... Requirements § 1033.110 Emission diagnostics—general requirements. The provisions of this section apply if you... diagnostics. See § 1033.420 for information about how to select and maintain diagnostic-equipped...

  18. 49 CFR 376.11 - General leasing requirements.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 5 2010-10-01 2010-10-01 false General leasing requirements. 376.11 Section 376.11 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL MOTOR CARRIER... INTERCHANGE OF VEHICLES Leasing Regulations § 376.11 General leasing requirements. Other than through...

  19. 30 CFR 816.61 - Use of explosives: General requirements.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 3 2010-07-01 2010-07-01 false Use of explosives: General requirements. 816.61... ACTIVITIES § 816.61 Use of explosives: General requirements. (a) Each operator shall comply with all applicable State and Federal laws and regulations in the use of explosives. (b) Blasts that use more than 5...

  20. 49 CFR 229.137 - Sanitation, general requirements.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Sanitation, general requirements. 229.137 Section... Cab Equipment § 229.137 Sanitation, general requirements. (a) Sanitation compartment. Except as provided in paragraph (b) of this section, all lead locomotives in use shall be equipped with a...

  1. 49 CFR 173.60 - General packaging requirements for explosives.

    Science.gov (United States)

    2010-10-01

    ...) through either design of the packaging or of the article, or both. (11) Plastic packagings may not be able... 49 Transportation 2 2010-10-01 2010-10-01 false General packaging requirements for explosives. 173...-GENERAL REQUIREMENTS FOR SHIPMENTS AND PACKAGINGS Definitions, Classification and Packaging for Class 1...

  2. 7 CFR 322.28 - General requirements; restricted articles.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 5 2010-01-01 2010-01-01 false General requirements; restricted articles. 322.28... EQUIPMENT Importation and Transit of Restricted Articles § 322.28 General requirements; restricted articles. (a) The following articles from any region are restricted articles: (1) Dead bees of any genus;...

  3. [Off-label use in dermatological practice. The conflict between professional duty and legal requirements].

    Science.gov (United States)

    Brunne, V; Mertins, G; Reimann, G; Brockmeyer, N H

    2004-08-01

    When making therapeutic decisions, doctors often find themselves faced with a dilemma regarding ethical, professional, legal liability, social and service aspects of their duties. These conflicts may be enhanced when medications have to be prescribed for non-approved usages, known as off-label prescribing, because existing therapy options have been exhausted. This option become considerably more difficult since the German Federal Social Court decision of March 2002 which limited off-label use to a number of very strictly defined circumstances. In order to clarify the basis for taking decisions in a given situation, an oncology expert commission has been formed under the coordination of the Department of Health and Social Security. However, this is no solution for the great variety of uncommon dermatological diseases which often require off-label medication usage.

  4. 10 CFR Appendix A to Part 600 - Generally Applicable Requirements

    Science.gov (United States)

    2010-01-01

    ..., 1979, 3 CFR 1979 Comp., p. 474). Administrative and Fiscal Policy Requirements The Hatch Act (5 U.S.C... Appendix A to Part 600—Generally Applicable Requirements Socioeconomic Policy Requirements...). Architectural Barriers Act of 1968, as amended (42 U.S.C. 4151 et seq.). National Environmental Policy Act of...

  5. 40 CFR 80.572 - What labeling requirements apply to retailers and wholesale purchaser-consumers of NR and NRLM...

    Science.gov (United States)

    2010-07-01

    ... PROGRAMS (CONTINUED) REGULATION OF FUELS AND FUEL ADDITIVES Motor Vehicle Diesel Fuel; Nonroad, Locomotive, and Marine Diesel Fuel; and ECA Marine Fuel Labeling Requirements § 80.572 What labeling requirements... retailers and wholesale purchaser-consumers of NR and NRLM diesel fuel and heating oil beginning June...

  6. 40 CFR 80.573 - What labeling requirements apply to retailers and wholesale purchaser-consumers of NRLM diesel...

    Science.gov (United States)

    2010-07-01

    ... (CONTINUED) REGULATION OF FUELS AND FUEL ADDITIVES Motor Vehicle Diesel Fuel; Nonroad, Locomotive, and Marine Diesel Fuel; and ECA Marine Fuel Labeling Requirements § 80.573 What labeling requirements apply to... retailers and wholesale purchaser-consumers of NRLM diesel fuel and heating oil beginning June 1, 2012?...

  7. 16 CFR 316.4 - Requirement to place warning labels on commercial electronic mail that contains sexually oriented...

    Science.gov (United States)

    2010-01-01

    ... 16 Commercial Practices 1 2010-01-01 2010-01-01 false Requirement to place warning labels on commercial electronic mail that contains sexually oriented material. 316.4 Section 316.4 Commercial Practices FEDERAL TRADE COMMISSION REGULATIONS UNDER SPECIFIC ACTS OF CONGRESS CAN-SPAM RULE § 316.4 Requirement to place warning labels on commercial...

  8. 7 CFR 205.400 - General requirements for certification.

    Science.gov (United States)

    2010-01-01

    ... MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) ORGANIC FOODS PRODUCTION ACT PROVISIONS NATIONAL ORGANIC PROGRAM Certification § 205.400 General requirements for certification. A person seeking to receive or maintain organic certification under...

  9. 22 CFR 62.8 - General program requirements.

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false General program requirements. 62.8 Section 62.8 Foreign Relations DEPARTMENT OF STATE PUBLIC DIPLOMACY AND EXCHANGES EXCHANGE VISITOR PROGRAM General... sponsors to give their exchange visitors the broadest exposure to American society, culture...

  10. 48 CFR 801.602-70 - General review requirements.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false General review requirements. 801.602-70 Section 801.602-70 Federal Acquisition Regulations System DEPARTMENT OF VETERANS AFFAIRS GENERAL DEPARTMENT OF VETERANS AFFAIRS ACQUISITION REGULATION SYSTEM Career Development, Contracting Authority, and Responsibilities 801.602-70...

  11. 48 CFR 9903.202-1 - General requirements.

    Science.gov (United States)

    2010-10-01

    ... immediately preceding cost accounting period was less than $25 million. (ii) Any business unit that is....202-1 Section 9903.202-1 Federal Acquisition Regulations System COST ACCOUNTING STANDARDS BOARD... ACCOUNTING STANDARDS CONTRACT COVERAGE CAS Program Requirements 9903.202-1 General requirements. (a)...

  12. 14 CFR 61.153 - Eligibility requirements: General.

    Science.gov (United States)

    2010-01-01

    ... (CONTINUED) AIRMEN CERTIFICATION: PILOTS, FLIGHT INSTRUCTORS, AND GROUND INSTRUCTORS Airline Transport Pilots § 61.153 Eligibility requirements: General. To be eligible for an airline transport pilot certificate... rating issued under this part; (2) Meet the military experience requirements under § 61.73 of this...

  13. 14 CFR 49.43 - Eligibility for recording: general requirements.

    Science.gov (United States)

    2010-01-01

    ... TRANSPORTATION AIRCRAFT RECORDING OF AIRCRAFT TITLES AND SECURITY DOCUMENTS Encumbrances Against Specifically Identified Aircraft Engines and Propellers § 49.43 Eligibility for recording: general requirements. A..., 49.13, and 49.17, the following requirements are met: (a) It affects and describes an aircraft...

  14. 14 CFR 49.53 - Eligibility for recording: general requirements.

    Science.gov (United States)

    2010-01-01

    ... TRANSPORTATION AIRCRAFT RECORDING OF AIRCRAFT TITLES AND SECURITY DOCUMENTS Encumbrances Against Air Carrier Aircraft Engines, Propellers, Appliances, and Spare Parts § 49.53 Eligibility for recording: general... requirements of §§ 49.11, 49.13, and 49.17, the following requirements are met: (1) It affects any...

  15. Comparison of the hedonic general Labeled Magnitude Scale with the hedonic 9-point scale.

    Science.gov (United States)

    Kalva, Jaclyn J; Sims, Charles A; Puentes, Lorenzo A; Snyder, Derek J; Bartoshuk, Linda M

    2014-02-01

    The hedonic 9-point scale was designed to compare palatability among different food items; however, it has also been used occasionally to compare individuals and groups. Such comparisons can be invalid because scale labels (for example, "like extremely") can denote systematically different hedonic intensities across some groups. Addressing this problem, the hedonic general Labeled Magnitude Scale (gLMS) frames affective experience in terms of the strongest imaginable liking/disliking of any kind, which can yield valid group comparisons of food palatability provided extreme hedonic experiences are unrelated to food. For each scale, 200 panelists rated affect for remembered food products (including favorite and least favorite foods) and sampled foods; they also sampled taste stimuli (quinine, sucrose, NaCl, citric acid) and rated their intensity. Finally, subjects identified experiences representing the endpoints of the hedonic gLMS. Both scales were similar in their ability to detect within-subject hedonic differences across a range of food experiences, but group comparisons favored the hedonic gLMS. With the 9-point scale, extreme labels were strongly associated with extremes in food affect. In contrast, gLMS data showed that scale extremes referenced nonfood experiences. Perceived taste intensity significantly influenced differences in food liking/disliking (for example, those experiencing the most intense tastes, called supertasters, showed more extreme liking and disliking for their favorite and least favorite foods). Scales like the hedonic gLMS are suitable for across-group comparisons of food palatability.

  16. A general procedure for isotopic (deuterium) labelling of non-steroidal antiinflammatory 2-arylpropionic acids

    Energy Technology Data Exchange (ETDEWEB)

    Castell, J.V. (Valencia Univ. Hospital (Spain). Centro de Investigacion); Martinez, L.A. (Valencia Univ. Hospital (Spain). Centro de Investigacion Universidad Politecnica de Valencia (Spain). Dept. de Quimica); Miranda, M.A.; Tarrega, Pilar (Universidad Politecnica de Valencia (Spain). Dept. de Quimica)

    1994-01-01

    Alkaline treatment of nonsteroidal antiinflammatory 2-arylpropionic acids in deuterium oxide led in all cases to isotopic exchange of the proton located at the [alpha]-position of the side chain. Monodeuteration was observed in the case of carprofen, ibuprofen, ketoprofen, fenoprofen, flurbiprofen and naproxen. Additional exchange of one or two protons of the heterocyclic ring occurred in indoprofen, suprofen and tiaprofenic acid. The isotopic labelling survived under the conditions required to perform in vitro photoallergic studies (photolysis in non-deuterated aqueous media). (Author).

  17. Family-Joining: A Fast Distance-Based Method for Constructing Generally Labeled Trees.

    Science.gov (United States)

    Kalaghatgi, Prabhav; Pfeifer, Nico; Lengauer, Thomas

    2016-10-01

    The widely used model for evolutionary relationships is a bifurcating tree with all taxa/observations placed at the leaves. This is not appropriate if the taxa have been densely sampled across evolutionary time and may be in a direct ancestral relationship, or if there is not enough information to fully resolve all the branching points in the evolutionary tree. In this article, we present a fast distance-based agglomeration method called family-joining (FJ) for constructing so-called generally labeled trees in which taxa may be placed at internal vertices and the tree may contain polytomies. FJ constructs such trees on the basis of pairwise distances and a distance threshold. We tested three methods for threshold selection, FJ-AIC, FJ-BIC, and FJ-CV, which minimize Akaike information criterion, Bayesian information criterion, and cross-validation error, respectively. When compared with related methods on simulated data, FJ-BIC was among the best at reconstructing the correct tree across a wide range of simulation scenarios. FJ-BIC was applied to HIV sequences sampled from individuals involved in a known transmission chain. The FJ-BIC tree was found to be compatible with almost all transmission events. On average, internal branches in the FJ-BIC tree have higher bootstrap support than branches in the leaf-labeled bifurcating tree constructed using RAxML. 36% and 25% of the internal branches in the FJ-BIC tree and RAxML tree, respectively, have bootstrap support greater than 70%. To the best of our knowledge the method presented here is the first attempt at modeling evolutionary relationships using generally labeled trees.

  18. 40 CFR 88.305-94 - Clean-fuel fleet vehicle labeling requirements for heavy-duty vehicles.

    Science.gov (United States)

    2010-07-01

    ... clean-fuel fleet vehicles not regulated under 40 CFR part 86 shall have a permanent legible label...-duty engines and vehicles used as LEVs, ULEVs, and ZEVs that are also regulated under 40 CFR part 86 shall comply with the labeling requirements of 40 CFR 86.095-35 (or later applicable sections),...

  19. A general method for site specific fluorescent labeling of recombinant chemokines.

    Directory of Open Access Journals (Sweden)

    Tetsuya Kawamura

    Full Text Available Chemokines control cell migration in many contexts including development, homeostasis, immune surveillance and inflammation. They are also involved in a wide range of pathological conditions ranging from inflammatory diseases and cancer, to HIV. Chemokines function by interacting with two types of receptors: G protein-coupled receptors on the responding cells, which transduce signaling pathways associated with cell migration and activation, and glycosaminoglycans on cell surfaces and the extracellular matrix which organize and present some chemokines on immobilized surface gradients. To probe these interactions, imaging methods and fluorescence-based assays are becoming increasingly desired. Herein, a method for site-specific fluorescence labeling of recombinant chemokines is described. It capitalizes on previously reported 11-12 amino acid tags and phosphopantetheinyl transferase enzymes to install a fluorophore of choice onto a specific serine within the tag through a coenzyme A-fluorophore conjugate. The generality of the method is suggested by our success in labeling several chemokines (CXCL12, CCL2, CCL21 and mutants thereof and visualizing them bound to chemokine receptors and glycosaminoglycans. CXCL12 and CCL2 showed the expected co-localization on the surface of cells with their respective receptors CXCR4 and CCR2 at 4 °C, and co-internalization with their receptors at 37 °C. By contrast, CCL21 showed the presence of large discrete puncta that were dependent on the presence of both CCR7 and glycosaminoglycans as co-receptors. These data demonstrate the utility of this labeling approach for the detection of chemokine interactions with GAGs and receptors, which can vary in a chemokine-specific manner as shown here. For some applications, the small size of the fluorescent adduct may prove advantageous compared to other methods (e.g. antibody labeling, GFP fusion by minimally perturbing native interactions. Other advantages of the method

  20. 17 CFR 210.7-02 - General requirement.

    Science.gov (United States)

    2010-04-01

    ... statements filed for mutual life insurance companies and wholly owned stock insurance company subsidiaries of... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false General requirement. 210.7-02 Section 210.7-02 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION FORM AND CONTENT...

  1. 30 CFR 816.111 - Revegetation: General requirements.

    Science.gov (United States)

    2010-07-01

    ... ACTIVITIES § 816.111 Revegetation: General requirements. (a) The permittee shall establish on regraded areas and on all other disturbed areas except water areas and surface areas of roads that are approved as... vegetation of the area; and (4) Capable of stabilizing the soil surface from erosion. (b) The...

  2. 30 CFR 817.111 - Revegetation: General requirements.

    Science.gov (United States)

    2010-07-01

    ... ACTIVITIES § 817.111 Revegetation: General requirements. (a) The permittee shall establish on regraded areas and on all other disturbed areas except water areas and surface areas of roads that are approved as... vegetation of the area; and (4) Capable of stabilizing the soil surface from erosion. (b) The...

  3. 31 CFR 128.1 - General reporting requirements.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false General reporting requirements. 128.1 Section 128.1 Money and Finance: Treasury Regulations Relating to Money and Finance REPORTING OF... credit that are, in whole or part, denominated in a foreign currency; and (iii) The creation or...

  4. 40 CFR 86.230-11 - Test sequence: general requirements.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 18 2010-07-01 2010-07-01 false Test sequence: general requirements. 86.230-11 Section 86.230-11 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR... New Medium-Duty Passenger Vehicles; Cold Temperature Test Procedures § 86.230-11 Test...

  5. 40 CFR 205.55-1 - General requirements.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false General requirements. 205.55-1 Section 205.55-1 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) NOISE ABATEMENT PROGRAMS TRANSPORTATION EQUIPMENT NOISE EMISSION CONTROLS Medium and Heavy Trucks § 205.55-1...

  6. 40 CFR 86.230-94 - Test sequence: general requirements.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 18 2010-07-01 2010-07-01 false Test sequence: general requirements. 86.230-94 Section 86.230-94 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR... New Medium-Duty Passenger Vehicles; Cold Temperature Test Procedures § 86.230-94 Test...

  7. 24 CFR 904.204 - General requirements and information.

    Science.gov (United States)

    2010-04-01

    ... successful participation in the homeownership development. (i) An overload of information should be avoided... information. 904.204 Section 904.204 Housing and Urban Development Regulations Relating to Housing and Urban... § 904.204 General requirements and information. (a) The counseling and training program shall be...

  8. 21 CFR 101.14 - Health claims: general requirements.

    Science.gov (United States)

    2010-04-01

    ... claim, to FDA's satisfaction, to be safe and lawful under the applicable food safety provisions of the... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Health claims: general requirements. 101.14 Section 101.14 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN...

  9. Video-Games: Do They Require General Intelligence?

    Science.gov (United States)

    Quiroga, M. A.; Herranz, M.; Gomez-Abad, M.; Kebir, M.; Ruiz, J.; Colom, Roberto

    2009-01-01

    Here we test if playing video-games require intelligence. Twenty-seven university undergraduate students were trained on three games from Big Brain Academy (Wii): Calculus, Backward Memory and Train. Participants did not have any previous experience with these games. General intelligence was measured by five ability tests before the training…

  10. 7 CFR 322.13 - General requirements; restricted organisms.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 5 2010-01-01 2010-01-01 false General requirements; restricted organisms. 322.13 Section 322.13 Agriculture Regulations of the Department of Agriculture (Continued) ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE BEES, BEEKEEPING BYPRODUCTS, AND...

  11. 15 CFR 27.116 - General requirements for informed consent.

    Science.gov (United States)

    2010-01-01

    ... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false General requirements for informed consent. 27.116 Section 27.116 Commerce and Foreign Trade Office of the Secretary of Commerce PROTECTION... description of any reasonably foreseeable risks or discomforts to the subject; (3) A description of...

  12. 30 CFR 816.102 - Backfilling and grading: General requirements.

    Science.gov (United States)

    2010-07-01

    ..., acid- and toxic-forming materials, and combustible materials exposed, used, or produced during mining.... 816.102 Section 816.102 Mineral Resources OFFICE OF SURFACE MINING RECLAMATION AND ENFORCEMENT...-SURFACE MINING ACTIVITIES § 816.102 Backfilling and grading: General requirements. (a) Disturbed...

  13. 30 CFR 817.102 - Backfilling and grading: General requirements.

    Science.gov (United States)

    2010-07-01

    .... 817.102 Section 817.102 Mineral Resources OFFICE OF SURFACE MINING RECLAMATION AND ENFORCEMENT...-UNDERGROUND MINING ACTIVITIES § 817.102 Backfilling and grading: General requirements. (a) Disturbed areas... leaching of toxic materials. (d) Spoil may be placed on the area outside the mined-out surface area...

  14. 30 CFR 28.40 - Construction and performance requirements; general.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Construction and performance requirements; general. 28.40 Section 28.40 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR TESTING, EVALUATION, AND APPROVAL OF MINING PRODUCTS FUSES FOR USE WITH DIRECT CURRENT IN PROVIDING...

  15. 10 CFR 4.126 - General requirement concerning accessibility.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false General requirement concerning accessibility. 4.126 Section 4.126 Energy NUCLEAR REGULATORY COMMISSION NONDISCRIMINATION IN FEDERALLY ASSISTED PROGRAMS OR... inaccessible to or unusable by handicapped persons, be denied the benefits of, be excluded from...

  16. 40 CFR 63.2250 - What are the general requirements?

    Science.gov (United States)

    2010-07-01

    ... Standards for Hazardous Air Pollutants: Plywood and Composite Wood Products General Compliance Requirements... stoppages of direct-fired softwood veneer dryers or over-temperature events shall be deemed shutdowns and not malfunctions. Lighting or re-lighting any one or all gas burners in direct-fired softwood...

  17. 14 CFR 65.71 - Eligibility requirements: General.

    Science.gov (United States)

    2010-01-01

    ... (CONTINUED) AIRMEN CERTIFICATION: AIRMEN OTHER THAN FLIGHT CREWMEMBERS Mechanics § 65.71 Eligibility requirements: General. (a) To be eligible for a mechanic certificate and associated ratings, a person must— (1... sections of this subpart that apply to the rating he seeks. (b) A certificated mechanic who applies for...

  18. Recovery schemes for different distributed connection management in generalized multi-protocol label switching networks

    Institute of Scientific and Technical Information of China (English)

    Can Wang; Yuefeng Ji

    2007-01-01

    As the wavelength division multiplexing (WDM) technology matures and the demands for bandwidth increase, survivability becomes more and more important in generalized multi-protocol label switching (GMPLS) controlled intelligent optical networks (IONs). There are great interests to study the performance of restorability under one certain connection management strategy. And studies in the problem of providing recovery from link failures under two different resource reservation schemes, forward reservation protocols (FRPs) and backward reservation protocols (BRPs), are presented. They are examined from the point of view of connection blocking probability, restorability and average recovery time. The two different connection management schemes and the survey of different recovery schemes are first presented. The performance of these recovery strategies is analyzed and compared both through theoretical analysis and simulation results. The main stressed idea is that using BRPs gives the best performance in terms of restorability and blocking probability in restorable GMPLS networks.

  19. The roles of human values and generalized trust on stated preferences when food is labeled with environmental footprints

    DEFF Research Database (Denmark)

    Grebitus, Carola; Steiner, Bodo; Veeman, Michele

    2015-01-01

    This study explores stated preferences for food labeled with environmental footprints, concentrating on human values (Rokeach 1973) and trust attitudes (Uslaner 2002). An online survey, conducted in Germany during 2011 (n = 1579), collected data on human values using the Rokeach Value Survey (Rok...... that accounting for consumers’ value system and generalized trust attitudes – as well as traditional socio-demographics – adds value when trying to understand choices and identify new target markets for footprint-labeled food products....

  20. Connected Components Labeling on the GPU with Generalization to Voronoi Diagrams and Signed Distance Fields

    DEFF Research Database (Denmark)

    Rasmusson, Allan; Sørensen, Thomas Sangild; Ziegler, Gernot

    2013-01-01

    Many image processing problems benefit from a complete solution to connected components labeling. This paper introduces a new data parallel labeling method based on calculation of label propagation sizes from the connectivity between pixels extracted in a pre-processing step and re-usal of establ...

  1. Connected Components Labeling on the GPU with Generalization to Voronoi Diagrams and Signed Distance Fields

    DEFF Research Database (Denmark)

    Rasmusson, Allan; Sørensen, Thomas Sangild; Ziegler, Gernot

    2013-01-01

    Many image processing problems benefit from a complete solution to connected components labeling. This paper introduces a new data parallel labeling method based on calculation of label propagation sizes from the connectivity between pixels extracted in a pre-processing step and re...

  2. 16 CFR 1500.121 - Labeling requirements; prominence, placement, and conspicuousness.

    Science.gov (United States)

    2010-01-01

    ... label of such a substance and shall appear in conspicuous and legible type in contrast by typography... typography, layout, or color with other printed matter on the label. The signal word and statement of... typography, layout, or color with the other printed matter on the label, such statements shall conform to...

  3. Evaluation of the general university requirements: what did students say?

    Science.gov (United States)

    Shek, Daniel T L; Yu, Lu; Chai, Wen Yu

    2017-02-01

    The General University Requirements (GUR) is the core general education component of the new 4-year undergraduate curriculum at The Hong Kong Polytechnic University (PolyU) commencing from the 2012/2013 academic year. The major objective of the GUR is to widen students' horizons and promote their holistic development in their undergraduate years. To evaluate the perceived effectiveness of the GUR in its second year implementation, 18 focus group interviews (n=74 students) were conducted in the 2013/2014 academic year. Findings showed that subjects under the GUR framework were overall welcomed by students for the well-designed subject contents, dedicated teaching staff, and collaborative and experiential learning methods. Students perceived that the GUR was beneficial to their development in effective communication, critical thinking, problem solving, lifelong learning, and ethical leadership. Some challenges encountered by students were noted to further revamp the GUR curriculum in the future.

  4. Context generalization in Drosophila visual learning requires the mushroom bodies

    Science.gov (United States)

    Liu, Li; Wolf, Reinhard; Ernst, Roman; Heisenberg, Martin

    1999-08-01

    The world is permanently changing. Laboratory experiments on learning and memory normally minimize this feature of reality, keeping all conditions except the conditioned and unconditioned stimuli as constant as possible. In the real world, however, animals need to extract from the universe of sensory signals the actual predictors of salient events by separating them from non-predictive stimuli (context). In principle, this can be achieved ifonly those sensory inputs that resemble the reinforcer in theirtemporal structure are taken as predictors. Here we study visual learning in the fly Drosophila melanogaster, using a flight simulator,, and show that memory retrieval is, indeed, partially context-independent. Moreover, we show that the mushroom bodies, which are required for olfactory but not visual or tactile learning, effectively support context generalization. In visual learning in Drosophila, it appears that a facilitating effect of context cues for memory retrieval is the default state, whereas making recall context-independent requires additional processing.

  5. GENERAL CONSIDERATIONS ON REGULATIONS AND SAFETY REQUIREMENTS FOR QUADRICYCLES

    Directory of Open Access Journals (Sweden)

    Ana Pavlovic

    2015-12-01

    Full Text Available In recent years, a new class of compact vehicles has been emerging and wide-spreading all around Europe: the quadricycle. These four-wheeled motor vehicles, originally derived from motorcycles, are a small and fuel-efficient mean of transportation used in rural or urban areas as an alternative to motorbikes or city cars. In some countries, they are also endorsed by local authorities and institutions which support small and environmentally-friendly vehicles. In this paper, several general considerations on quadricycles will be provided including the vehicle classification, evolution of regulations (as homologation, driver licence, emissions, etc, technical characteristics, safety requirements, most relevant investigations, and other additional useful information (e.g. references, links. It represents an important and actual topic of investigation for designers and manufacturers considering that the new EU regulation on the approval and market surveillance of quadricycles will soon enter in force providing conclusive requirements for functional safety environmental protection of these promising vehicles.

  6. 21 CFR 201.15 - Drugs; prominence of required label statements.

    Science.gov (United States)

    2010-04-01

    ... appear thereon in the English language: Provided, however, That in the case of articles distributed... than English, the predominant language may be substituted for English. (2) If the label contains any... use of label space for any representation in a foreign language. (c)(1) All words, statements,...

  7. Dietary supplement labeling and advertising claims: are clinical studies on the full product required?

    Science.gov (United States)

    Villafranco, John E; Bond, Katie

    2009-01-01

    Whether labeling and advertising claims for multi-ingredient dietary supplements may be based on the testing of individual, key ingredients--rather than the actual product--has caused a good deal of confusion. This confusion stems from the dearth of case law and the open-endedness of Federal Trade Commission (FTC) and Food and Drug Administration (FDA) guidance on this issue. Nevertheless, the relevant regulatory guidance, case law and self-regulatory case law--when assessed together--indicate that the law allows and even protects "key ingredient claims" (i.e., claims based on efficacy testing of key ingredients in the absence of full product testing). This article provides an overview of the relevant substantiation requirements for dietary supplement claims and then reviews FTC's and FDA's guidance on key ingredient claims; relevant case law; use of key ingredient claims in the advertising of other consumer products; and the National Advertising Division of the Better Business Bureau, Inc.'s (NAD's) approach to evaluating key ingredient claims for dietary supplements. This article concludes that key ingredient claims--provided they are presented in a truthful and non-deceptive manner--are permissible, and should be upheld in litigation and cases subject to industry self-regulation. This article further concludes that the NAD's approach to key ingredient claims provides practical guidance for crafting and substantiating dietary supplement key ingredient claims.

  8. Modeling of Testability Requirement Based on Generalized Stochastic Petri Nets

    Institute of Scientific and Technical Information of China (English)

    SU Yong-ding; QIU Jing; LIU Guan-jun; QIAN Yan-ling

    2009-01-01

    Testability design is an effective way to realize the fault detection and isolation. Its important step is to determine testability figures of merits (TFOM). Firstly, some influence factors for TFOMs are analyzed, such as the processes of system operation, maintenance and support, fault detection and isolation and so on. Secondly, a testability requirement analysis model is built based on generalized stochastic Petri net (GSPN). Then, the system's reachable states are analyzed based on the model, a Markov chain isomorphic with Petri net is constructed, a state transition matrix is created and the system's steady state probability is obtained. The relationship between the steady state availability and testability parameters can be revealed and reasoned. Finally, an example shows that the proposed method can determine TFOM, such as fault detection rate and fault isolation rate, effectively and reasonably.

  9. 49 CFR 176.600 - General stowage requirements.

    Science.gov (United States)

    2010-10-01

    ..., and be stowed away from all sources of heat and ignition. .... (c) Each package bearing a POISON label displaying the text “PG III” or bearing a “PG III” mark... (poisonous gas) material or Division 6.1 (poison) material which also bears a FLAMMABLE LIQUID or...

  10. The roles of human values and generalized trust on stated preferences when food is labeled with environmental footprints

    DEFF Research Database (Denmark)

    Grebitus, Carola; Steiner, Bodo; Veeman, Michele

    2015-01-01

    This study explores stated preferences for food labeled with environmental footprints, concentrating on human values (Rokeach 1973) and trust attitudes (Uslaner 2002). An online survey, conducted in Germany during 2011 (n = 1579), collected data on human values using the Rokeach Value Survey (Rok...... that accounting for consumers’ value system and generalized trust attitudes – as well as traditional socio-demographics – adds value when trying to understand choices and identify new target markets for footprint-labeled food products.......This study explores stated preferences for food labeled with environmental footprints, concentrating on human values (Rokeach 1973) and trust attitudes (Uslaner 2002). An online survey, conducted in Germany during 2011 (n = 1579), collected data on human values using the Rokeach Value Survey...

  11. A GENERALIZATION OF TRADITIONAL KANO MODEL FOR CUSTOMER REQUIREMENTS ANALYSIS

    Directory of Open Access Journals (Sweden)

    Renáta Turisová

    2015-07-01

    Full Text Available Purpose: The theory of attractiveness determines the relationship between the technically achieved and customer perceived quality of product attributes. The most frequently used approach in the theory of attractiveness is the implementation of Kano‘s model. There exist a lot of generalizations of that model which take into consideration various aspects and approaches focused on understanding the customer preferences and identification of his priorities for a selling  product. The aim of this article is to outline another possible generalization of Kano‘s model.Methodology/Approach: The traditional Kano’s model captures the nonlinear relationship between reached attributes of quality and customer requirements. The individual attributes of quality are divided into three main categories: must-be, one-dimensional, attractive quality and into two side categories: indifferent and reverse quality. The well selling product has to contain the must-be attribute. It should contain as many one-dimensional attributes as possible. If there are also supplementary attractive attributes, it means that attractiveness of the entire product, from the viewpoint of the customer, nonlinearly sharply rises what has a direct positive impact on a decision of potential customer when purchasing the product. In this article, we show that inclusion of individual quality attributes of a product to the mentioned categories depends, among other things, also on costs on life cycle of the product, respectively on a price of the product on the market.Findings: In practice, we are often encountering the inclusion of products into different price categories: lower, middle and upper class. For a certain type of products the category is either directly declared by a producer (especially in automotive industry, or is determined by a customer by means of assessment of available market prices. To each of those groups of a products different customer expectations can be assigned

  12. 16 CFR 1404.4 - Requirements to provide performance and technical data by labeling-Notice to purchasers.

    Science.gov (United States)

    2010-01-01

    ... SAFETY COMMISSION CONSUMER PRODUCT SAFETY ACT REGULATIONS CELLULOSE INSULATION § 1404.4 Requirements to... purposes other than resale in the following manner. Manufacturers of cellulose insulation shall label all containers of cellulose insulation with the following statement, using capital letters as indicated: Caution...

  13. 21 CFR 111.165 - What requirements apply to a product received for packaging or labeling as a dietary supplement...

    Science.gov (United States)

    2010-04-01

    ... product that you receive for packaging or labeling as a dietary supplement (and for distribution rather... shipment of the received product to ensure that the received product is consistent with your purchase order... 21 Food and Drugs 2 2010-04-01 2010-04-01 false What requirements apply to a product received...

  14. 76 FR 17607 - Receipt of Request To Require Pesticide Products To Be Labeled in English and Spanish

    Science.gov (United States)

    2011-03-30

    ... and Spanish AGENCY: Environmental Protection Agency (EPA). ACTION: Notice of receipt of petition and... both English and Spanish. The Agency is taking public comment on the request before responding to the... advocacy organizations requesting that EPA require labeling in Spanish, in addition to the...

  15. The Case for Requiring Graphic Warning Labels on Smokeless Tobacco Product Packages.

    Science.gov (United States)

    Pakhale, Smita; Samet, Jonathan; Folan, Patricia; Leone, Frank; White, Alexander

    2016-03-01

    On November 10, 2015, the U.S. Food and Drug Administration approved, for the first time, the sale of smokeless tobacco products authorized under the new premarket tobacco application pathway. This Food and Drug Administration regulatory decision draws attention to the growing worldwide use of smokeless tobacco products in general. Use of these tobacco products is particularly popular in low- and middle-income countries of Asia. Due to aggressive and strategic marketing to children, young adults, and current smokers, rates of smokeless tobacco use in men of all ages are on the rise in United States and elsewhere. The tobacco industry also continues to market these products to current cigarette smokers for use in the growing number of "smoke-free environments." Smokeless tobacco products are associated with cancers of the upper aerodigestive tract, particularly the oral cavity, esophagus, and pancreas; cardiovascular diseases; small-for-gestational-age infants; premature births; increased risk of apnea; and stillbirth. There is no convincing evidence regarding the efficacy of smokeless tobacco, including snus, to promote smoking cessation. Rather, studies from Europe and the United States demonstrate that smokeless tobacco use may facilitate regular cigarette smoking by acting as a gateway drug, especially for children. Caution is warranted before proposing smokeless tobacco as a harm-reduction strategy, in part because of the potential for further promoting smokeless tobacco in low- and middle-income countries where use is already widespread. Continued vigilance through comprehensive surveillance is warranted. We strongly recommend the use of graphic warning labels as a "no regrets" strategy for all smokeless tobacco products marketed globally.

  16. Off-label and unlicensed prescribing of psychotropics in children in Dutch general practice .

    NARCIS (Netherlands)

    Volkers, A.; Dijk, L. van

    2006-01-01

    Background: Unsafe drug use is a point of concern in children with psychotropics. Methylfenidate is licensed to prescribe above the age of 6 years, but most of the antidepressants and benzodiazepines are not approved in children. We studied the off-label and unlicensed prescribing of psychotropics i

  17. Final Report - Dynamic Path Scheduling through Extensions to Generalized Multiprotocol Label Switching (GMPLS)

    Energy Technology Data Exchange (ETDEWEB)

    Principal Investigator: Dr. Abdella Battou

    2009-05-22

    The major accomplishments of the project are the successful software implementation of the Phase I scheduling algorithms for GMPLS Label Switched Paths (LSPs) and the extension of the IETF Path Computation Element (PCE) Protocol to support scheduling extensions. In performing this work, we have demonstrated the theoretical work of Phase I, analyzed key issues, and made relevant extensions. Regarding the software implementation, we developed a proof of concept prototype as part of our Algorithm Evaluation System (AES). This implementation uses the Linux operating system to provide software portability and will be the foundation for our commercial software. To demonstrate proof of concept, we have implemented LSP scheduling algorithms to support two of the key GMPLS switching technologies (Lambda and Packet) and support both Fixed Path (FP) and Switched Path (SP) routing. We chose Lambda and Packet because we felt it was essential to include both circuit and packet switching technologies as well as to address all-optical switching in the study. As conceptualized in Phase I, the FP algorithms use a traditional approach where the LSP uses the same physical path for the entire service duration while the innovative SP algorithms allow the physical path to vary during the service duration. As part of this study, we have used the AES to conduct a performance analysis using metro size networks (up to 32 nodes) that showed that these algorithms are suitable for commercial implementation. Our results showed that the CPU time required to compute an LSP schedule was small compared to expected inter-arrival time between LSP requests. Also, when the network size increased from 7 to 15 to 32 nodes with 10, 26, and 56 TE links, the CPU processing time showed excellent scaling properties. When Fixed Path and Switched Path routing were compared, SP provided only modestly better performance with respect to LSP completion rate, service duration, path length, and start time deviation

  18. Discrepancy between the composition of some commercial cat foods and their package labelling and suitability for meeting nutritional requirements.

    Science.gov (United States)

    Gosper, E C; Raubenheimer, D; Machovsky-Capuska, G E; Chaves, A V

    2016-01-01

    To investigate if the label information and nutrient composition of commercial cat foods are accurate and compliant with the Australian Standard (AS 5812-2011) and if they meet the nutritional requirements of an adult cat. A chemical analysis of 10 wet and 10 dry commercial cat foods labelled as 'nutritionally complete' for the adult cat was performed. The results were compared with the package composition values, the Australian Standard and the unique dietary requirements of the cat. In addition, the results of the chemical analysis were compared with the nutrient requirements published by the Association of the American Feed Control Officials and the National Research Council. When compared with the Australian Standard, 9 of the 20 cat foods did not adhere to their 'guaranteed analysis' and 8 did not adhere to the standards for nutrient composition. Also, various deficiencies and excesses of crude protein, crude fat, fatty acid and amino acid were observed in the majority of the cat foods. The results of this study highlight a need for an improved method of ensuring that label information and nutrient composition are accurate and comply with the Australian Standard (AS 5812-2011) to ensure the adult cat's unique dietary requirements are being met by commercial adult cat food. © 2016 Australian Veterinary Association.

  19. 21 CFR 801.15 - Medical devices; prominence of required label statements.

    Science.gov (United States)

    2010-04-01

    ... English language: Provided, however, That in the case of articles distributed solely in the Commonwealth of Puerto Rico or in a Territory where the predominant language is one other than English, the predominant language may be substituted for English. (2) If the label contains any representation in a...

  20. Photonic Crystal Surfaces as a General Purpose Platform for Label-Free and Fluorescent Assays

    OpenAIRE

    Cunningham, Brian T.

    2010-01-01

    Photonic crystal surfaces can be designed to provide a wide range of functions that are used to perform biochemical and cell-based assays. Detection of the optical resonant reflections from photonic crystal surfaces enables high sensitivity label-free biosensing, while the enhanced electromagnetic fields that occur at resonant wavelengths can be used to enhance the detection sensitivity of any surface-based fluorescence assay. Fabrication of photonic crystals from inexpensive plastic material...

  1. 13 CFR 107.1120 - General eligibility requirements for Leverage.

    Science.gov (United States)

    2010-01-01

    ... geographic areas. (g) Certify in writing that you are in compliance with the requirement to finance Smaller Enterprises in § 107.710(b). (h) Show, to the satisfaction of SBA, that your management is qualified and has... regulations in this part. (j) If required by SBA, have your Control Person(s) assume, in writing,...

  2. 10 CFR 712.11 - General requirements for HRP certification.

    Science.gov (United States)

    2010-01-01

    ... or recertification; (7) A psychological evaluation consisting of a generally accepted psychological..., “Drug-Free Federal Workplace Testing Implementation Program,” for DOE employees; (9) An initial...

  3. 49 CFR 543.5 - Petition: General requirements.

    Science.gov (United States)

    2010-10-01

    ... an exemption of one car line from the requirements of part 541 of this chapter. However, for car... lines to be exempted, and identify that model year; (5) Identify the passenger motor vehicle line...

  4. 46 CFR 11.1105 - General requirements for officer's endorsements.

    Science.gov (United States)

    2010-10-01

    ..., you must— (a) Meet the appropriate requirements of the STCW Regulation V/3 and of section A-V/3 of the STCW Code (incorporated by reference, see § 11.102); and (b) Hold documentary evidence to show that...

  5. GENERAL REQUIREMENTS FOR SIMULATION MODELS IN WASTE MANAGEMENT

    Energy Technology Data Exchange (ETDEWEB)

    Miller, Ian; Kossik, Rick; Voss, Charlie

    2003-02-27

    Most waste management activities are decided upon and carried out in a public or semi-public arena, typically involving the waste management organization, one or more regulators, and often other stakeholders and members of the public. In these environments, simulation modeling can be a powerful tool in reaching a consensus on the best path forward, but only if the models that are developed are understood and accepted by all of the parties involved. These requirements for understanding and acceptance of the models constrain the appropriate software and model development procedures that are employed. This paper discusses requirements for both simulation software and for the models that are developed using the software. Requirements for the software include transparency, accessibility, flexibility, extensibility, quality assurance, ability to do discrete and/or continuous simulation, and efficiency. Requirements for the models that are developed include traceability, transparency, credibility/validity, and quality control. The paper discusses these requirements with specific reference to the requirements for performance assessment models that are used for predicting the long-term safety of waste disposal facilities, such as the proposed Yucca Mountain repository.

  6. [Precision medicine : a required approach for the general internist].

    Science.gov (United States)

    Waeber, Gérard; Cornuz, Jacques; Gaspoz, Jean-Michel; Guessous, Idris; Mooser, Vincent; Perrier, Arnaud; Simonet, Martine Louis

    2017-01-18

    The general internist cannot be a passive bystander of the anticipated medical revolution induced by precision medicine. This latter aims to improve the predictive and/or clinical course of an individual by integrating all biological, genetic, environmental, phenotypic and psychosocial knowledge of a person. In this article, national and international initiatives in the field of precision medicine are discussed as well as the potential financial, ethical and limitations of personalized medicine. The question is not to know if precision medicine will be part of everyday life but rather to integrate early the general internist in multidisciplinary teams to ensure optimal information and shared-decision process with patients and individuals.

  7. 40 CFR 63.2150 - What are my general requirements for complying with this subpart?

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 12 2010-07-01 2010-07-01 true What are my general requirements for... SOURCE CATEGORIES National Emission Standards for Hazardous Air Pollutants: Manufacturing of Nutritional Yeast General Compliance Requirements § 63.2150 What are my general requirements for complying with this...

  8. 17 CFR 4.34 - General disclosures required.

    Science.gov (United States)

    2010-04-01

    ... IS OFTEN OBTAINABLE IN COMMODITY TRADING CAN WORK AGAINST YOU AS WELL AS FOR YOU. THE USE OF LEVERAGE.... 4.34 Section 4.34 Commodity and Securities Exchanges COMMODITY FUTURES TRADING COMMISSION COMMODITY POOL OPERATORS AND COMMODITY TRADING ADVISORS Commodity Trading Advisors § 4.34 General...

  9. 16 CFR 1028.116 - General requirements for informed consent.

    Science.gov (United States)

    2010-01-01

    .... 1028.116 Section 1028.116 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION GENERAL PROTECTION OF... subject's legal rights, or releases or appears to release the investigator, the sponsor, the institution... subjects' rights, and whom to contact in the event of a research-related injury to the subject; and (8) A...

  10. 18 CFR 157.6 - Applications; general requirements.

    Science.gov (United States)

    2010-04-01

    ... that a docket number is assigned to the application, in a daily or weekly newspaper of general... property: (i) Is directly affected (i.e., crossed or used) by the proposed activity, including all facility... right-of-way or facility site owned in fee by any utility company, or abuts the edge of a...

  11. 46 CFR 183.370 - General grounding requirements.

    Science.gov (United States)

    2010-10-01

    ... requirements. (a) A vessel's hull must not carry current as a conductor except for the following systems: (1... more, must have a grounding pole and a grounding conductor in the portable cord. (c) Each nonmetallic mast and top mast must have a lightning ground conductor....

  12. 14 CFR 65.101 - Eligibility requirements: General.

    Science.gov (United States)

    2010-01-01

    ... applicant who does not meet this requirement and who is employed outside the United States by a certificated... paragraph (a)(3) of this section, have this certificate endorsed “Valid only outside the United States.” (b...) under § 65.104 or to a repairman certificate (light-sport aircraft) under § 65.107....

  13. 46 CFR 12.25-10 - General requirements.

    Science.gov (United States)

    2010-10-01

    ..., ordinary seaman, wiper, and steward's department (F.H.) endorsements do not require an exam. Holders of.... MMCs or MMDs endorsed as steward's department (F.H.) will authorize the holder's service in any capacity in the steward's department. (See § 12.02-11(b) of this part for unqualified ratings in the...

  14. 47 CFR 90.403 - General operating requirements.

    Science.gov (United States)

    2010-10-01

    ... facilities are employed: (1) Only for permissible purposes; (2) Only in a permissible manner; and (3) Only by... or notification of a deviation from the technical requirements of the station authorization and until such deviation is corrected. For transmissions concerning the imminent safety-of-life or property,...

  15. 7 CFR 1427.5 - General eligibility requirements.

    Science.gov (United States)

    2010-01-01

    ... premiums and discounts for ELS cotton; and (3) Have an extraneous matter specified in the schedules of premiums and discounts for extraneous matter for ELS cotton. (d) In addition to the requirements of... micronaire premiums and discounts for upland cotton; (5) Have an extraneous matter within the...

  16. 42 CFR 84.1156 - Pesticide respirators; performance requirements; general.

    Science.gov (United States)

    2010-10-01

    ... resistance will be measured in the facepiece, mouthpiece, hood, or helmet of a pesticide respirator mounted... allowable resistance requirements for pesticide respirators are as follows: Maximum Resistance Type of... 42 Public Health 1 2010-10-01 2010-10-01 false Pesticide respirators; performance...

  17. 40 CFR 86.1773-99 - Test sequence; general requirements.

    Science.gov (United States)

    2010-07-01

    ... required for fuel-flexible and dual-fuel vehicles when operating on gasoline. Natural gas, hybrid electric and diesel-fueled vehicles shall also be exempt from 50 °F testing. (3) The following schedule... vehicle shall be approximately level during all phases of the test sequence to prevent abnormal fuel...

  18. 12 CFR 226.5 - General disclosure requirements.

    Science.gov (United States)

    2010-01-01

    ... disclosures and use of estimates. Disclosures shall reflect the terms of the legal obligation between the... forth in those sections. (2) Terminology. (i) Terminology used in providing the disclosures required by... use of estimates. Disclosures shall reflect the terms of the legal obligation between the parties. If...

  19. 40 CFR 79.51 - General requirements and provisions.

    Science.gov (United States)

    2010-07-01

    ... same total combination of atypical elements as that occurring in the fuel product in question. If the... elements not represented in the test formulation, then the fuel manufacturer is also responsible for... PROGRAMS (CONTINUED) REGISTRATION OF FUELS AND FUEL ADDITIVES Testing Requirements for Registration §...

  20. 30 CFR 28.41 - Testing requirements; general.

    Science.gov (United States)

    2010-07-01

    ....41 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR TESTING, EVALUATION, AND APPROVAL OF MINING PRODUCTS FUSES FOR USE WITH DIRECT CURRENT IN PROVIDING SHORT-CIRCUIT PROTECTION FOR TRAILING CABLES IN COAL MINES Construction, Performance, and Testing Requirements §...

  1. Photonic Crystal Surfaces as a General Purpose Platform for Label-Free and Fluorescent Assays.

    Science.gov (United States)

    Cunningham, Brian T

    2010-04-01

    Photonic crystal surfaces can be designed to provide a wide range of functions that are used to perform biochemical and cell-based assays. Detection of the optical resonant reflections from photonic crystal surfaces enables high sensitivity label-free biosensing, while the enhanced electromagnetic fields that occur at resonant wavelengths can be used to enhance the detection sensitivity of any surface-based fluorescence assay. Fabrication of photonic crystals from inexpensive plastic materials over large surface areas enables them to be incorporated into standard formats that include microplates, microarrays, and microfluidic channels. This report reviews the design of photonic crystal biosensors, their associated detection instrumentation, and biological applications. Applications including small molecule high throughput screening, cell membrane integrin activation, gene expression analysis, and protein biomarker detection are highlighted. Recent results in which photonic crystal surfaces are used for enhancing the detection of Surface-Enhanced Raman Spectroscopy, and the development of high resolution photonic crystal-based laser biosensors are also described.

  2. Military Specification: Mobility, Towed Aerospace Ground Equipment General Requirements for.

    Science.gov (United States)

    1974-02-01

    Seven Conductor Electrical Connector for Truck Trailer Jumper Cable J585 Tail Lamps (Rear Position Light) J586 Stop Lamps J588 Turn Signal Lamps J592...Wiring: NOTE: Normally not required for Groups A, B, and C items; equipment specification. Lighting Complete Complete Turn signals Yes Yes Voltage 12V...J585 Turn signals SAE J588, class A. 3.11.2 Vehicles less than 80 inches wide. Items less than 80 inches wide shall contain the lighting devices, and

  3. A Generalized Cauchy Distribution Framework for Problems Requiring Robust Behavior

    Science.gov (United States)

    Carrillo, Rafael E.; Aysal, Tuncer C.; Barner, Kenneth E.

    2010-12-01

    Statistical modeling is at the heart of many engineering problems. The importance of statistical modeling emanates not only from the desire to accurately characterize stochastic events, but also from the fact that distributions are the central models utilized to derive sample processing theories and methods. The generalized Cauchy distribution (GCD) family has a closed-form pdf expression across the whole family as well as algebraic tails, which makes it suitable for modeling many real-life impulsive processes. This paper develops a GCD theory-based approach that allows challenging problems to be formulated in a robust fashion. Notably, the proposed framework subsumes generalized Gaussian distribution (GGD) family-based developments, thereby guaranteeing performance improvements over traditional GCD-based problem formulation techniques. This robust framework can be adapted to a variety of applications in signal processing. As examples, we formulate four practical applications under this framework: (1) filtering for power line communications, (2) estimation in sensor networks with noisy channels, (3) reconstruction methods for compressed sensing, and (4) fuzzy clustering.

  4. A Generalized Cauchy Distribution Framework for Problems Requiring Robust Behavior

    Directory of Open Access Journals (Sweden)

    Carrillo RafaelE

    2010-01-01

    Full Text Available Statistical modeling is at the heart of many engineering problems. The importance of statistical modeling emanates not only from the desire to accurately characterize stochastic events, but also from the fact that distributions are the central models utilized to derive sample processing theories and methods. The generalized Cauchy distribution (GCD family has a closed-form pdf expression across the whole family as well as algebraic tails, which makes it suitable for modeling many real-life impulsive processes. This paper develops a GCD theory-based approach that allows challenging problems to be formulated in a robust fashion. Notably, the proposed framework subsumes generalized Gaussian distribution (GGD family-based developments, thereby guaranteeing performance improvements over traditional GCD-based problem formulation techniques. This robust framework can be adapted to a variety of applications in signal processing. As examples, we formulate four practical applications under this framework: (1 filtering for power line communications, (2 estimation in sensor networks with noisy channels, (3 reconstruction methods for compressed sensing, and (4 fuzzy clustering.

  5. On ASGS framework: general requirements and an example of implementation

    Institute of Scientific and Technical Information of China (English)

    KULESZA Kamil; KOTULSKI Zbigniew

    2007-01-01

    In the paper we propose a general, abstract framework for Automatic Secret Generation and Sharing (ASGS) that should be independent of underlying Secret Sharing Scheme (SSS). ASGS allows to prevent the Dealer from knowing the secret.The Basic Property Conjecture (BPC) forms the base of the framework. Due to the level of abstraction, results are portable into the realm of quantum computing.Two situations are discussed. First concerns simultaneous generation and sharing of the random, prior nonexistent secret.Such a secret remains unknown until it is reconstructed. Next, we propose the framework for automatic sharing of a known secret.In this case the Dealer does not know the secret and the secret Owner does not know the shares. We present opportunities for joining ASGS with other extended capabilities, with special emphasis on PVSS and pre-positioned secret sharing. Finally, we illustrate framework with practical implementation.

  6. 77 FR 6463 - Revisions to Labeling Requirements for Blood and Blood Components, Including Source Plasma...

    Science.gov (United States)

    2012-02-08

    ... Requirements for Blood and Blood Components, Including Source Plasma; Correction AGENCY: Food and Drug... Blood Components, Including Source Plasma,'' which provided incorrect publication information...

  7. 29 CFR 1910.124 - General requirements for dipping and coating operations.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 5 2010-07-01 2010-07-01 false General requirements for dipping and coating operations... Dipping and Coating Operations § 1910.124 General requirements for dipping and coating operations. (a...) Chemical reaction. (c) What requirements must I follow to recirculate exhaust air into the workplace?...

  8. 75 FR 54025 - Revision of LNG and LHG Waterfront Facility General Requirements

    Science.gov (United States)

    2010-09-03

    ...-27022] RIN 1625-AB13 Revision of LNG and LHG Waterfront Facility General Requirements AGENCY: Coast...) requirements for liquefied natural gas (LNG) and liquefied hazardous gas (LHG) facilities. The amendment... entitled ``Revision of LNG and LHG Waterfront Facility General Requirements'' (75 FR 29420) amending...

  9. 38 CFR 52.61 - General requirements for adult day health care program.

    Science.gov (United States)

    2010-07-01

    ....61 General requirements for adult day health care program. Adult day health care must be a... knowledge and skills necessary to manage care requirements in the home. Adult day health care is principally... 38 Pensions, Bonuses, and Veterans' Relief 2 2010-07-01 2010-07-01 false General requirements for...

  10. Pregabalin augmentation of antidepressants in older patients with comorbid depression and generalized anxiety disorder-an open-label study.

    Science.gov (United States)

    Karaiskos, Dimitrios; Pappa, Dimitra; Tzavellas, Elias; Siarkos, Kostas; Katirtzoglou, Everina; Papadimitriou, George N; Politis, Antonios

    2013-01-01

    The objective of this 12-week open-label study was to evaluate the efficacy, safety, and tolerability of pregabalin as an adjunctive treatment to antidepressants in older patients suffering from depression and comorbid generalized anxiety disorder (GAD). The initial sample of this open-label study consisted of 94 older patients fulfilling criteria for depression with comorbid GAD who were treated with antidepressants. Twenty of them who had received antidepressant monotherapy for an adequate time and shown partial response to the antidepressant prescribed, in terms of either anxiety or depressive symptomatology, followed the next phase. During the 12-week study period, pregabalin was gradually added to the previously prescribed antidepressant, reaching 225 mg/day over 4 weeks. Depression and anxiety scores as well as side effects were monitored. Within groups, differences of depression and anxiety scores at baseline and during the following 12 weeks of treatment were estimated with repeated-measure analysis of variance. A statistical significant reduction in depression scores was observed after the 4th week of treatment (p anxiety scores, a statistically significant improvement was noted between the 2nd and 4th weeks (p anxiety and depressive symptomatology significantly improved, and minimal side effects were observed. Copyright © 2012 John Wiley & Sons, Ltd.

  11. 77 FR 36423 - Labeling Requirements for Alternative Fuels and Alternative Fueled Vehicles

    Science.gov (United States)

    2012-06-19

    ..., coal-derived liquid fuels, fuels derived from biological materials (e.g., 100% biodiesel), and... requirements appear unnecessary.\\18\\ \\17\\ 42 U.S.C. 13211(3)(B). According to the legislative history,...

  12. General method of preparation of uniformly {sup 13}C, {sup 15}N-labeled DNA fragments for NMR analysis of DNA structures

    Energy Technology Data Exchange (ETDEWEB)

    Rene, Brigitte; Masliah, Gregoire; Zargarian, Loussine; Mauffret, Olivier; Fermandjian, Serge [UMR 8113 CNRS - LBPA Ecole Normale Superieure de Cachan, Institut Gustave Roussy, Departement de Biologie et Pharmacologie Structurales (France)], E-mail: sfermand@igr.fr

    2006-11-15

    Summary{sup 13}C, {sup 15}N labeling of biomolecules allows easier assignments of NMR resonances and provides a larger number of NMR parameters, which greatly improves the quality of DNA structures. However, there is no general DNA-labeling procedure, like those employed for proteins and RNAs. Here, we describe a general and widely applicable approach designed for preparation of isotopically labeled DNA fragments that can be used for NMR studies. The procedure is based on the PCR amplification of oligonucleotides in the presence of labeled deoxynucleotides triphosphates. It allows great flexibility thanks to insertion of a short DNA sequence (linker) between two repeats of DNA sequence to study. Size and sequence of the linker are designed as to create restriction sites at the junctions with DNA of interest. DNA duplex with desired sequence and size is released upon enzymatic digestion of the PCR product. The suitability of the procedure is validated through the preparation of two biological relevant DNA fragments.

  13. 78 FR 23832 - Labeling Requirements for Alternative Fuels and Alternative Fueled Vehicles

    Science.gov (United States)

    2013-04-23

    ... that run on liquid and non-liquid fuels, such as ethanol and other alcohols, including E85 ethanol... vehicle's estimated driving range (i.e., the travel distance on a single charge or tank of fuel), general... liquid fuels, or fuels (other than alcohol) derived from biological materials. See 76 FR 39478 (July...

  14. 76 FR 31513 - Labeling Requirements for Alternative Fuels and Alternative Fueled Vehicles

    Science.gov (United States)

    2011-06-01

    ... AFVs that run on liquid and non-liquid fuels, such as ethanol and other alcohols including E85 ethanol... vehicle's estimated cruising range (i.e., the travel distance on a single charge or tank of fuel), general... by liquefied petroleum gas, hydrogen, coal-derived liquid fuels, or fuels (other than...

  15. Commercial speech and off-label drug uses: what role for wide acceptance, general recognition and research incentives?

    Science.gov (United States)

    Gilhooley, Margaret

    2011-01-01

    This article provides an overview of how the constitutional protections for commercial speech affect the Food and Drug Administration's (FDA) regulation of drugs, and the emerging issues about the scope of these protections. A federal district court has already found that commercial speech allows manufacturers to distribute reprints of medical articles about a new off-label use of a drug as long as it contains disclosures to prevent deception and to inform readers about the lack of FDA review. This paper summarizes the current agency guidance that accepts the manufacturer's distribution of reprints with disclosures. Allergan, the maker of Botox, recently maintained in a lawsuit that the First Amendment permits drug companies to provide "truthful information" to doctors about "widely accepted" off-label uses of a drug. While the case was settled as part of a fraud and abuse case on other grounds, extending constitutional protections generally to "widely accepted" uses is not warranted, especially if it covers the use of a drug for a new purpose that needs more proof of efficacy, and that can involve substantial risks. A health law academic pointed out in an article examining a fraud and abuse case that off-label use of drugs is common, and that practitioners may lack adequate dosage information about the off-label uses. Drug companies may obtain approval of a drug for a narrow use, such as for a specific type of pain, but practitioners use the drug for similar uses based on their experience. The writer maintained that a controlled study may not be necessary to establish efficacy for an expanded use of a drug for pain. Even if this is the case, as discussed below in this paper, added safety risks may exist if the expansion covers a longer period of time and use by a wider number of patients. The protections for commercial speech should not be extended to allow manufacturers to distribute information about practitioner use with a disclosure about the lack of FDA

  16. General, Label-Free Method for Determining K(d) and Ligand Concentration Simultaneously.

    Science.gov (United States)

    Jalali-Yazdi, Farzad; Takahashi, Terry T; Roberts, Richard W

    2015-12-01

    Some of the most commonly used affinity reagents (e.g., antibodies) are often developed and used in conditions where their input concentrations ([L]0) and affinities (K(d)) are not known. Here, we have developed a general approach to determine both [L]0 and K(d) values simultaneously for affinity reagents (small molecules, proteins, and antibodies). To do this, we perform quantitative equilibrium exclusion immunoassays with two different concentrations of target and fit the data simultaneously to determine K(d) and [L]0. The results give accurate and reproducible measures of both values compared to established methods. By performing detailed error analysis, we demonstrate that our fitting gives unique solutions and indicates where K(d) and [L]0 measures are reliable. Furthermore, we found that a divalent model of antibody binding gives accurate K(d) and [L]0 values in both the forward (antibody immobilized) and the reverse (target immobilized) assays-addressing the long-term problem of obtaining quantitative data from reverse assays.

  17. 49 CFR 192.711 - Transmission lines: General requirements for repair procedures.

    Science.gov (United States)

    2010-10-01

    ... Maintenance § 192.711 Transmission lines: General requirements for repair procedures. (a) Temporary repairs... 49 Transportation 3 2010-10-01 2010-10-01 false Transmission lines: General requirements for..., imperfection, or damage that impairs its serviceability is found in a segment of steel transmission...

  18. 32 CFR 22.305 - General policy and requirement for competition.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 1 2010-07-01 2010-07-01 false General policy and requirement for competition... GRANT AND AGREEMENT REGULATIONS DoD GRANTS AND AGREEMENTS-AWARD AND ADMINISTRATION Competition § 22.305 General policy and requirement for competition. (a) It is DoD policy to maximize use of competition in...

  19. 21 CFR 1240.80 - General requirements for water for drinking and culinary purposes.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false General requirements for water for drinking and... DRUG ADMINISTRATION CONTROL OF COMMUNICABLE DISEASES Source and Use of Potable Water § 1240.80 General requirements for water for drinking and culinary purposes. Only potable water shall be provided for...

  20. 40 CFR 264.97 - General ground-water monitoring requirements.

    Science.gov (United States)

    2010-07-01

    ... FACILITIES Releases From Solid Waste Management Units § 264.97 General ground-water monitoring requirements. The owner or operator must comply with the following requirements for any ground-water monitoring... 40 Protection of Environment 25 2010-07-01 2010-07-01 false General ground-water...

  1. 30 CFR 250.1010 - General requirements for pipeline right-of-way holders.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false General requirements for pipeline right-of-way holders. 250.1010 Section 250.1010 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE... Rights-of-Way § 250.1010 General requirements for pipeline right-of-way holders. An applicant,...

  2. 33 CFR 149.505 - What are the general requirements for aids to navigation?

    Science.gov (United States)

    2010-07-01

    ... for aids to navigation? 149.505 Section 149.505 Navigation and Navigable Waters COAST GUARD... EQUIPMENT Aids to Navigation General § 149.505 What are the general requirements for aids to navigation? The following requirements apply to navigation aids under this subpart: (a) Section 66.01-5 of this chapter, on...

  3. Including 10-Gigabit-capable Passive Optical Network under End-to-End Generalized Multi-Protocol Label Switching Provisioned Quality of Service

    DEFF Research Database (Denmark)

    Brewka, Lukasz Jerzy; Gavler, Anders; Wessing, Henrik

    2012-01-01

    End-to-end quality of service provisioning is still a challenging task despite many years of research and development in this area. Considering a generalized multi-protocol label switching based core/metro network and resource reservation protocol capable home gateways, it is the access part...... of the network where quality of service signaling is bridged. This article proposes strategies for generalized multi-protocol label switching control over next emerging passive optical network standard, i.e., the 10-gigabit-capable passive optical network. Node management and resource allocation approaches...... are discussed, and possible issues are raised. The analysis shows that consideration of a 10-gigabit-capable passive optical network as a generalized multi-protocol label switching controlled domain is valid and may advance end-to-end quality of service provisioning for passive optical network based customers....

  4. 77 FR 18 - General Working Conditions in Shipyard Employment; Approval of Information Collection Requirements

    Science.gov (United States)

    2012-01-03

    ... Occupational Safety and Health Administration 29 CFR Part 1915 RIN 1218-AB50 General Working Conditions in... information requirements contained in the General Working Conditions Standard under the Paperwork Reduction...- 2222. SUPPLEMENTARY INFORMATION: OSHA published a final rule for General Working Conditions in...

  5. Reserve Component General and Flag Officers: A Review of Requirements and Authorized Strength

    Science.gov (United States)

    2016-01-01

    Reserve Component General and Flag Offi cers A Review of Requirements and Authorized Strength Lisa M. Harrington, Igor Mikolic-Torreira, Geoffrey...however, some RC G/FO requirements that the reserve components cannot fill because of these limits. In addition, we have identified a small number of...49 vi Reserve Component General and Flag Officers: A Review of Requirements CHAPTER FIVE Considering Development in Setting

  6. Evaluation of safety and efficacy of zonisamide in adult patients with partial, generalized, and combined seizures: an open labeled, noncomparative, observational Indian study

    Directory of Open Access Journals (Sweden)

    Dash A

    2016-02-01

    Full Text Available Amitabh Dash,1 Sangeeta Ravat,2 Avathvadi Venkatesan Srinivasan,3 Ashutosh Shetty,4 Vivek Kumar,5 Renu Achtani,6 Vivek Narain Mathur,7 Boby Varkey Maramattom,8 Veeresh Bajpai,9 Nanjappa C Manjunath,10 Randhi Venkata Narayana,11 Suyog Mehta12 1Eisai Co. Ltd., 2Department of Neurology, Seth GS Medical College & KEM Hospital, Mumbai, 3Department of Neurology, Trinity Acute Care Hospital, Chennai, 4Department of Neurology, Criticare Multispeciality Hospital & Research Centre, Mumbai, 5Department of Neurology, Metro Multispeciality Hospital, Noida, 6Department of Neurology, Mata Chanan Devi Hospital, New Delhi, 7Department of Neurology, Vivekananda Hospital, Hyderabad, 8Department of Neurology, Lourdes Hospital, Kochi, 9Department of Neurology, Sai Neurology Clinic, Lucknow, 10Department of Neurology, Brain and Nerve Care, Bangalore, 11Department of Neurology, Seven Hills Hospital, Visakhapatnam, 12Department of Pharmacology & Therapeutics,Government Medical College, Solapur, India Abstract: A prospective, multicentric, noncomparative open-label observational study was conducted to evaluate the safety and efficacy zonisamide in Indian adult patients for the treatment of partial, generalized, or combined seizures. A total of 655 adult patients with partial, generalized, or combined seizures from 30 centers across India were recruited after initial screening. Patients received 100 mg zonisamide as initiating dose as monotherapy/adjunctive therapy for 24 weeks, with titration of 100 mg every 2 weeks if required. Adverse events, responder rates, and seizure freedom were observed every 4 weeks. Efficacy and safety were also assessed using Clinicians Global Assessment of Response to Therapy and Patients Global Assessment of Tolerability to Therapy, respectively. Follow-up was conducted for a period of 24 weeks after treatment initiation. A total of 655 patients were enrolled and received the treatment and 563 completed the evaluation phase. A total of 20

  7. 47 CFR 73.1800 - General requirements related to the station log.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 4 2010-10-01 2010-10-01 false General requirements related to the station log... requirements related to the station log. (a) The licensee of each station must maintain a station log as required by § 73.1820. This log shall be kept by station employees competent to do so, having...

  8. 9 CFR 113.64 - General requirements for live bacterial vaccines.

    Science.gov (United States)

    2010-01-01

    ... bacterial vaccines. 113.64 Section 113.64 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION... STANDARD REQUIREMENTS Live Bacterial Vaccines § 113.64 General requirements for live bacterial vaccines... bacterial vaccine shall meet the requirements in this section. (a) Purity test. Final container samples of...

  9. 9 CFR 113.200 - General requirements for killed virus vaccines.

    Science.gov (United States)

    2010-01-01

    ... vaccines. 113.200 Section 113.200 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE... REQUIREMENTS Killed Virus Vaccines § 113.200 General requirements for killed virus vaccines. When prescribed in an applicable Standard Requirement or in the filed Outline of Production, a killed virus vaccine...

  10. 9 CFR 113.300 - General requirements for live virus vaccines.

    Science.gov (United States)

    2010-01-01

    ... vaccines. 113.300 Section 113.300 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE... REQUIREMENTS Live Virus Vaccines § 113.300 General requirements for live virus vaccines. When prescribed in an applicable Standard Requirement or in the filed Outline of Production, a live virus vaccine shall meet the...

  11. Short-term open-label chamomile (Matricaria chamomilla L.) therapy of moderate to severe generalized anxiety disorder.

    Science.gov (United States)

    Keefe, John R; Mao, Jun J; Soeller, Irene; Li, Qing S; Amsterdam, Jay D

    2016-12-15

    Conventional drug treatments for Generalized Anxiety Disorder (GAD) are often accompanied by substantial side effects, dependence, and/or withdrawal syndrome. A prior controlled study of oral chamomile (Matricaria chamomilla L.) extract showed significant efficacy versus placebo, and suggested that chamomile may have anxiolytic activity for individuals with GAD. We hypothesized that treatment with chamomile extract would result in a significant reduction in GAD severity ratings, and would be associated with a favorable adverse event and tolerability profile. We report on the open-label phase of a two-phase randomized controlled trial of chamomile versus placebo for relapse-prevention of recurrent GAD. Subjects with moderate to severe GAD received open-label treatment with pharmaceutical-grade chamomile extract 1500mg/day for up to 8 weeks. Primary outcomes were the frequency of clinical response and change in GAD-7 symptom scores by week 8. Secondary outcomes included the change over time on the Hamilton Rating Scale for Anxiety, the Beck Anxiety Inventory, and the Psychological General Well Being Index. Frequency of treatment-emergent adverse events and premature treatment discontinuation were also examined. Of 179 subjects, 58.1% (95% CI: 50.9% to 65.5%) met criteria for response, while 15.6% prematurely discontinued treatment. Significant improvement over time was also observed on the GAD-7 rating (β=-8.4 [95% CI=-9.1 to -7.7]). A similar proportion of subjects demonstrated statistically significant and clinically meaningful reductions in secondary outcome ratings of anxiety and well-being. Adverse events occurred in 11.7% of subjects, although no serious adverse events occurred. Chamomile extract produced a clinically meaningful reduction in GAD symptoms over 8 weeks, with a response rate comparable to those observed during conventional anxiolytic drug therapy and a favorable adverse event profile. Future comparative effectiveness trials between chamomile and

  12. A general Monte Carlo/simulated annealing algorithm for resonance assignment in NMR of uniformly labeled biopolymers

    Science.gov (United States)

    Hu, Kan-Nian; Qiang, Wei; Tycko, Robert

    2011-01-01

    We describe a general computational approach to site-specific resonance assignments in multidimensional NMR studies of uniformly 15N,13C-labeled biopolymers, based on a simple Monte Carlo/simulated annealing (MCSA) algorithm contained in the program MCASSIGN2. Input to MCASSIGN2 includes lists of multidimensional signals in the NMR spectra with their possible residue-type assignments (which need not be unique), the biopolymer sequence, and a table that describes the connections that relate one signal list to another. As output, MCASSIGN2 produces a high-scoring sequential assignment of the multidimensional signals, using a score function that rewards good connections (i.e., agreement between relevant sets of chemical shifts in different signal lists) and penalizes bad connections, unassigned signals, and assignment gaps. Examination of a set of high-scoring assignments from a large number of independent runs allows one to determine whether a unique assignment exists for the entire sequence or parts thereof. We demonstrate the MCSA algorithm using two-dimensional (2D) and three-dimensional (3D) solid state NMR spectra of several model protein samples (α-spectrin SH3 domain and protein G/B1 microcrystals, HET-s218–289 fibrils), obtained with magic-angle spinning and standard polarization transfer techniques. The MCSA algorithm and MCASSIGN2 program can accommodate arbitrary combinations of NMR spectra with arbitrary dimensionality, and can therefore be applied in many areas of solid state and solution NMR. PMID:21710190

  13. A general strategy for studying multi-site protein phosphorylation using label-free selected reaction monitoring mass spectrometry1

    OpenAIRE

    2011-01-01

    The majority of eukaryotic proteins are phosphorylated in vivo and phosphorylation may be the most common regulatory post-translational modification. Many proteins are phosphorylated at numerous sites, often by multiple kinases, which may have different functional consequences. Understanding biological functions of phosphorylation events requires methods to detect and quantify individual sites within a substrate. Here we outline a general strategy that addresses this need and relies on the hi...

  14. Hybridization of General Cargo Ships to meet the Required Energy Efficiency Design Index

    OpenAIRE

    Øverleir, Magnus Anders

    2015-01-01

    In this thesis a hybrid propulsion system is proposed for a general cargo ship with the aim to meet the required Energy Efficiency Design Index (EEDI). The study has investigated how a hybrid propulsion system will influence the ship s EEDI value and fuel economy. The central problem is the coming challenge for the general cargo segment meeting the required efficiency value. Especially small vessels (3 000-15 000 DWT) with high speed will have troubles complying with the stricter regulations....

  15. 14 CFR 294.3 - General requirements for Canadian charter air taxi operators.

    Science.gov (United States)

    2010-01-01

    ... air taxi operators. 294.3 Section 294.3 Aeronautics and Space OFFICE OF THE SECRETARY, DEPARTMENT OF TRANSPORTATION (AVIATION PROCEEDINGS) ECONOMIC REGULATIONS CANADIAN CHARTER AIR TAXI OPERATORS General § 294.3 General requirements for Canadian charter air taxi operators. A Canadian charter air taxi operator shall...

  16. 49 CFR 173.301b - Additional general requirements for shipment of UN pressure receptacles.

    Science.gov (United States)

    2010-10-01

    ... Group I performance level. (d) Non-refillable UN pressure receptacles. Non-refillable UN pressure... pressure receptacles. 173.301b Section 173.301b Transportation Other Regulations Relating to Transportation....301b Additional general requirements for shipment of UN pressure receptacles. (a) General....

  17. General University Requirements at Hong Kong Polytechnic University: Evaluation Findings Based on Student Focus Groups

    Science.gov (United States)

    Shek, Daniel Tan Lei; Yu, Lu; Wu, Florence Ka Yu; Chai, Wen Yu

    2015-01-01

    Under the new four-year undergraduate programme, a general education framework titled "General University Requirements" (GUR) has been developed and implemented since 2012/2013 at Hong Kong Polytechnic University (PolyU). To evaluate the implementation and effectiveness of the GUR in its first year, focus group interviews with students…

  18. 20 CFR 604.3 - Able and available requirement-general principles.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Able and available requirement-general principles. 604.3 Section 604.3 Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION, DEPARTMENT OF...—general principles. (a) A State may pay UC only to an individual who is able to work and available...

  19. 7 CFR 322.2 - General requirements for interstate movement and importation.

    Science.gov (United States)

    2010-01-01

    ... AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE BEES, BEEKEEPING BYPRODUCTS, AND BEEKEEPING EQUIPMENT General Provisions § 322.2 General requirements for interstate movement and importation..., honeybee germ plasm, and beekeeping byproducts into the United States only in accordance with this part....

  20. 30 CFR 817.71 - Disposal of excess spoil: General requirements.

    Science.gov (United States)

    2010-07-01

    .... 817.71 Section 817.71 Mineral Resources OFFICE OF SURFACE MINING RECLAMATION AND ENFORCEMENT...-UNDERGROUND MINING ACTIVITIES § 817.71 Disposal of excess spoil: General requirements. (a) General. You, the... stability of the fill. (5) Excess spoil that is acid- or toxic-forming or combustible shall be...

  1. 40 CFR 267.198 - What are the general operating requirements for my tank systems?

    Science.gov (United States)

    2010-07-01

    ... FACILITIES OPERATING UNDER A STANDARDIZED PERMIT Tank Systems § 267.198 What are the general operating... 40 Protection of Environment 26 2010-07-01 2010-07-01 false What are the general operating requirements for my tank systems? 267.198 Section 267.198 Protection of Environment ENVIRONMENTAL...

  2. 75 FR 29420 - Revision of LNG and LHG Waterfront Facility General Requirements

    Science.gov (United States)

    2010-05-26

    ... No. USCG-2007-27022] RIN 1625-AB13 Revision of LNG and LHG Waterfront Facility General Requirements... requirements for waterfront facilities handling liquefied natural gas (LNG) and liquefied hazardous gas (LHG... harmonize the Coast Guard's regulations for LNG with those established by the Federal Energy...

  3. 5 CFR 2634.201 - General requirements, filing dates, and extensions.

    Science.gov (United States)

    2010-01-01

    ... EXECUTIVE BRANCH FINANCIAL DISCLOSURE, QUALIFIED TRUSTS, AND CERTIFICATES OF DIVESTITURE Persons Required To File Public Financial Disclosure Reports § 2634.201 General requirements, filing dates, and extensions... days shall file a public financial disclosure report containing the information prescribed in subpart...

  4. 49 CFR 178.320 - General requirements applicable to all DOT specification cargo tank motor vehicles.

    Science.gov (United States)

    2010-10-01

    ...) Each cargo tank or cargo tank motor vehicle design type, including its required accident damage... specification cargo tank motor vehicles. 178.320 Section 178.320 Transportation Other Regulations Relating to... Transportation § 178.320 General requirements applicable to all DOT specification cargo tank motor vehicles....

  5. 40 CFR 80.59 - General test fleet requirements for vehicle testing.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 16 2010-07-01 2010-07-01 false General test fleet requirements for... test fleet requirements for vehicle testing. (a) The test fleet must consist of only 1989-91 MY... test fleet shall have no fewer than 4,000 miles of accumulated mileage prior to being included in...

  6. 42 CFR 483.354 - General requirements for psychiatric residential treatment facilities.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 5 2010-10-01 2010-10-01 false General requirements for psychiatric residential treatment facilities. 483.354 Section 483.354 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION REQUIREMENTS FOR STATES AND LONG TERM CARE FACILITIES Condition...

  7. Vecuronium and fentanyl requirement in abdominal surgery under combined epidural-general anaesthesia and general anaesthesia alone.

    Science.gov (United States)

    Hossain, M; Hoq, M F; Rahman, M S; Yeasmeen, S; Ahmed, A; Huda, M R; Rahman, M M

    2012-01-01

    Individual effect of epidural block and general anaesthesia is well established in the field of anaesthesiology. But adequate literature is yet not available to give decisive answer regarding the requirement of muscle relaxants and opioid analgesic when the two methods are combined together. In the present study, sixty patients, aged 18-50 years of both sexes with ASA (American Society of Anesthesiologists) grading I and II scheduled to undergo for major abdominal surgery were assigned randomly into two groups (30 in each group), where Group A received general anesthesia and Group B received combined epidural-general anesthesia. The patients with combined technique, epidural catheter tip were placed between T9-10. Ten ml of 0.125% bupivacaine was administered through the epidural catheter. Peripheral nerve stimulator was used to monitor neuromuscular transmission and subsequently to administer incremental dose of neuromuscular blocking drugs. All the patients were pre-medicated with fentanyl (2μg/kg) to reduce intubation reflex. Then the patients of both groups were pre-oxygenated for 3 minute and anaesthesia was induced with thiopental sodium 3-5 mg/kg body weight. Endotrachial intubation was facilitated by vecuronium 0.1mg/kg body weight. Anaesthesia was maintained with 60% N2O in O2 and halothane (0.4 to 0.8%). Fentanyl was given in incremental dose of 0.5 μg/kg to maintain an adequate analgesia. The vecuronium was given at the dose of 0.02 mg/kg, when TOF return to 25% of the base line. The mean±SD requirement of vecuronium in general anaesthesia group was 0.0016±0.00013 mg/kg/min and whereas in combined epidural-general anaesthesia, it was 0.0011±0.00014 mg/kg/min. The requirement of fentanyl was 0.71μg/kg/hr in general anaesthetic group whereas in combined group it was 0.31μg/kg/hr. These findings prompt us to place optimal dosing guidelines so as to avoid overdosing and thus delay recovery and help to get the excellent outcome of the surgery.

  8. General method for labeling siRNA by click chemistry with fluorine-18 for the purpose of PET imaging.

    Science.gov (United States)

    Mercier, Frédéric; Paris, Jérôme; Kaisin, Geoffroy; Thonon, David; Flagothier, Jessica; Teller, Nathalie; Lemaire, Christian; Luxen, André

    2011-01-19

    The alkyne-azide Cu(I)-catalyzed Huisgen cycloaddition, a click-type reaction, was used to label a double-stranded oligonucleotide (siRNA) with fluorine-18. An alkyne solid support CPG for the preparation of monostranded oligonucleotides functionalized with alkyne has been developed. Two complementary azide labeling agents (1-(azidomethyl)-4-[(18)F]fluorobenzene) and 1-azido-4-(3-[(18)F]fluoropropoxy)benzene have been produced with 41% and 35% radiochemical yields (decay-corrected), respectively. After annealing with the complementary strand, the siRNA was directly labeled by click chemistry with [(18)F]fluoroazide to produce the [(18)F]-radiolabeled siRNA with excellent radiochemical yield and purity.

  9. A Map of General and Specialized Chromatin Readers in Mouse Tissues Generated by Label-free Interaction Proteomics

    DEFF Research Database (Denmark)

    Eberl, H.C.; Mann, M.; Spruijt, C.G.;

    2013-01-01

    . Here we describe a sensitive, label-free histone peptide pull-down technology with extracts of different mouse tissues. Applying this workflow to the classical activating and repressive epigenetic marks on histone H3, H3K4me3, and H3K9me3, we identified known and putative readers in extracts from brain...

  10. Teaching Generalized Reading of Product Warning Labels to Young Adults with Autism Using the Constant Time Delay Procedure

    Science.gov (United States)

    Dogoe, Maud S.; Banda, Devender R.; Lock, Robin H.; Feinstein, Rita

    2011-01-01

    This study examined the effectiveness of the constant timed delay procedure for teaching two young adults with autism to read, define, and state the contextual meaning of keywords on product warning labels of common household products. Training sessions were conducted in the dyad format using flash cards. Results indicated that both participants…

  11. 42 CFR 84.1140 - Dust, fume, and mist respirators; performance requirements; general.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Dust, fume, and mist respirators; performance... Respirators and Combination Gas Masks § 84.1140 Dust, fume, and mist respirators; performance requirements; general. Dust, fume, and mist respirators and the individual components of each such device shall,...

  12. 42 CFR 84.206 - Particulate tests; respirators with filters; minimum requirements; general.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Particulate tests; respirators with filters... RESPIRATORY PROTECTIVE DEVICES Chemical Cartridge Respirators § 84.206 Particulate tests; respirators with filters; minimum requirements; general. (a) Three respirators with cartridges containing, or...

  13. 42 CFR 84.1158 - Dust, fume, and mist tests; respirators with filters; minimum requirements; general.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Dust, fume, and mist tests; respirators with...-Purifying High Efficiency Respirators and Combination Gas Masks § 84.1158 Dust, fume, and mist tests; respirators with filters; minimum requirements; general. (a) Three respirators with cartridges containing,...

  14. 5 CFR 2634.903 - General requirements, filing dates, and extensions.

    Science.gov (United States)

    2010-01-01

    ... EXECUTIVE BRANCH FINANCIAL DISCLOSURE, QUALIFIED TRUSTS, AND CERTIFICATES OF DIVESTITURE Confidential Financial Disclosure Reports § 2634.903 General requirements, filing dates, and extensions. (a) Incumbents... days in the twelve-month period, then a confidential financial disclosure report must be filed...

  15. 40 CFR 60.18 - General control device and work practice requirements.

    Science.gov (United States)

    2010-07-01

    ... § 60.18 General control device and work practice requirements. (a) Introduction. (1) This section... MJ/scm (300 Btu/scf) or greater if the flare is steam-assisted or air-assisted; or with the net heating value of the gas being combusted being 7.45 MJ/scm (200 Btu/scf) or greater if the flare...

  16. 40 CFR 1033.201 - General requirements for obtaining a certificate of conformity.

    Science.gov (United States)

    2010-07-01

    ... certificate of conformity. 1033.201 Section 1033.201 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY....201 General requirements for obtaining a certificate of conformity. Certification is the process by... certificate of conformity for freshly manufactured locomotives. Anyone meeting the definition...

  17. 40 CFR 35.929-2 - General requirements for all user charge systems.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false General requirements for all user charge systems. 35.929-2 Section 35.929-2 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... hookups or discharges to the users; (iv) Property valuation of the users, if the grantee has a user...

  18. 29 CFR 4.172 - Meeting requirements for particular fringe benefits-in general.

    Science.gov (United States)

    2010-07-01

    ... particular fringe benefits—in general. Where a fringe benefit determination specifies the amount of the... amount stated in the determination and the actual cost of the benefits which he provides. Unless... covered contract must be furnished the fringe benefits required by that determination for all hours...

  19. 49 CFR 232.103 - General requirements for all train brake systems.

    Science.gov (United States)

    2010-10-01

    ... pneumatic technology, the integrity of the train line shall be monitored by the brake control system. (c) A... straight air brake 30-50 (7) Self-lapping portion for electro-pneumatic brake (minimum full application... 49 Transportation 4 2010-10-01 2010-10-01 false General requirements for all train brake...

  20. 7 CFR 319.56-3 - General requirements for all imported fruits and vegetables.

    Science.gov (United States)

    2010-01-01

    ..., or finds that the fruit or vegetable may have been associated with other articles infested with plant... and Vegetables § 319.56-3 General requirements for all imported fruits and vegetables. All fruits and... parts. All fruits and vegetables imported under this subpart, whether in commercial or noncommercial...

  1. 50 CFR 25.23 - What are the general regulations and information collection requirements?

    Science.gov (United States)

    2010-10-01

    ... collect information to assist us in administering our programs in accordance with statutory authorities... information collection requirements? 25.23 Section 25.23 Wildlife and Fisheries UNITED STATES FISH AND... PROVISIONS Administrative Provisions § 25.23 What are the general regulations and information...

  2. 42 CFR 84.99 - Man tests; testing conditions; general requirements.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Man tests; testing conditions; general requirements. 84.99 Section 84.99 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE DEVICES Self-Contained Breathing Apparatus § 84.99...

  3. 40 CFR 63.996 - General monitoring requirements for control and recovery devices.

    Science.gov (United States)

    2010-07-01

    ... SOURCE CATEGORIES (CONTINUED) National Emission Standards for Closed Vent Systems, Control Devices, Recovery Devices and Routing to a Fuel Gas System or a Process § 63.996 General monitoring requirements for... cycle and the temperature of the carbon bed determined within 15 minutes of the completion of...

  4. 30 CFR 206.179 - What general requirements regarding processing allowances apply to me?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What general requirements regarding processing allowances apply to me? 206.179 Section 206.179 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR MINERALS REVENUE MANAGEMENT PRODUCT VALUATION Indian Gas Processing Allowances §...

  5. 49 CFR 173.40 - General packaging requirements for toxic materials packaged in cylinders.

    Science.gov (United States)

    2010-10-01

    ... concrete or steel, impacting at an orientation most likely to cause damage. “Deformation”means a cylinder... packaged in cylinders. 173.40 Section 173.40 Transportation Other Regulations Relating to Transportation... Transportation § 173.40 General packaging requirements for toxic materials packaged in cylinders. When this...

  6. 30 CFR 75.1103-3 - Automatic fire sensor and warning device systems; minimum requirements; general.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Automatic fire sensor and warning device...-UNDERGROUND COAL MINES Fire Protection § 75.1103-3 Automatic fire sensor and warning device systems; minimum requirements; general. Automatic fire sensor and warning device systems installed in belt haulageways of...

  7. 30 CFR 817.13 - Casing and sealing of exposed underground openings: General requirements.

    Science.gov (United States)

    2010-07-01

    ... openings: General requirements. 817.13 Section 817.13 Mineral Resources OFFICE OF SURFACE MINING... PROGRAM PERFORMANCE STANDARDS-UNDERGROUND MINING ACTIVITIES § 817.13 Casing and sealing of exposed... regulatory authority to prevent acid or other toxic drainage from entering ground and surface waters,...

  8. In vitro preparation of radionuclides labeled blood cells: Status and requirements; Preparation in vitro des cellules du sang marquees par des radionucleides: statut et recommandations

    Energy Technology Data Exchange (ETDEWEB)

    Couret, I. [Service de medecine nucleaire et radiopharmacie, hopital Lapeyronie, CHU de Montpellier, 34 - Montpellier (France); Desruet, M.D. [Service de medecine nucleaire et radiopharmacie, CHU de Grenoble, 38 - Grenoble (France); Bolot, C. [Service de pharmacie, hospices civils de Lyon, groupement hospitalier Est, 69 - Bron (France); Chassel, M.L. [Service de pharmacie et radiopharmacie, centre hospitalier de Chambery, 73 - Chambery (France); Pellegrin, M. [Inserm U896, CRLC Val-d' Aurelle-Paul-Lamarque, IRCM, universite Montpellier 1, 34 - Montpellier (France)

    2010-11-15

    Labelled blood cells permit nuclear medicine imaging using their physiological behaviours. The radiolabeling must be performed in vitro because of the lack of specific markers and requires several highly technical stages of preparation. Labelled blood cells have not the medication drug status, so that the nuclear physician conducting the nuclear test is fully liable. In most cases, the physician delegates the technical responsibility to radio-pharmacists. Although the status of radiolabelled autologous cells is not legally defined and in the absence of a specific repository, it is essential that their preparation is subject to the requirements of the rules of French Good Manufacturing Practice published by Agence francaise de securite sanitaire des produits de sante (Afssaps). It would be desirable to harmonize the practices of radiolabeling cellular blood components by editing a repository. (authors)

  9. 40 CFR 80.574 - What labeling requirements apply to retailers and wholesale purchaser-consumers of ECA marine...

    Science.gov (United States)

    2010-07-01

    ... FUELS AND FUEL ADDITIVES Motor Vehicle Diesel Fuel; Nonroad, Locomotive, and Marine Diesel Fuel; and ECA.... EPA, Attn: Diesel Sulfur Alternative Label Request, 6406J, 1200 Pennsylvania Avenue, NW., Washington, DC 20460. (2) For overnight or courier services: U.S. EPA, Attn: Diesel Sulfur Alternative...

  10. Generalized Information Architecture for Managing Requirements in IBM?s Rational DOORS(r) Application.

    Energy Technology Data Exchange (ETDEWEB)

    Aragon, Kathryn M.; Eaton, Shelley M.; McCornack, Marjorie Turner; Shannon, Sharon A.

    2014-12-01

    When a requirements engineering effort fails to meet expectations, often times the requirements management tool is blamed. Working with numerous project teams at Sandia National Laboratories over the last fifteen years has shown us that the tool is rarely the culprit; usually it is the lack of a viable information architecture with well- designed processes to support requirements engineering. This document illustrates design concepts with rationale, as well as a proven information architecture to structure and manage information in support of requirements engineering activities for any size or type of project. This generalized information architecture is specific to IBM's Rational DOORS (Dynamic Object Oriented Requirements System) software application, which is the requirements management tool in Sandia's CEE (Common Engineering Environment). This generalized information architecture can be used as presented or as a foundation for designing a tailored information architecture for project-specific needs. It may also be tailored for another software tool. Version 1.0 4 November 201

  11. Purple Computational Environment With Mappings to ACE Requirements for the General Availability User Environment Capabilities

    Energy Technology Data Exchange (ETDEWEB)

    Barney, B; Shuler, J

    2006-08-21

    Purple is an Advanced Simulation and Computing (ASC) funded massively parallel supercomputer located at Lawrence Livermore National Laboratory (LLNL). The Purple Computational Environment documents the capabilities and the environment provided for the FY06 LLNL Level 1 General Availability Milestone. This document describes specific capabilities, tools, and procedures to support both local and remote users. The model is focused on the needs of the ASC user working in the secure computing environments at Los Alamos National Laboratory, Lawrence Livermore National Laboratory, and Sandia National Laboratories, but also documents needs of the LLNL and Alliance users working in the unclassified environment. Additionally, the Purple Computational Environment maps the provided capabilities to the Trilab ASC Computing Environment (ACE) Version 8.0 requirements. The ACE requirements reflect the high performance computing requirements for the General Availability user environment capabilities of the ASC community. Appendix A lists these requirements and includes a description of ACE requirements met and those requirements that are not met for each section of this document. The Purple Computing Environment, along with the ACE mappings, has been issued and reviewed throughout the Tri-lab community.

  12. 21 CFR 201.310 - Phenindione; labeling of drug preparations intended for use by man.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Phenindione; labeling of drug preparations intended for use by man. 201.310 Section 201.310 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) DRUGS: GENERAL LABELING Specific Labeling Requirements for Specific Drug Products § 201.310...

  13. The effects of general anesthetics on ESR spectra of spin labels in phosphatidylcholine vesicles containing purified Na,K-ATPase or microsomal protein

    Energy Technology Data Exchange (ETDEWEB)

    Shibuya, Makiko, E-mail: shibu@den.hokudai.ac.jp [Department of Dental Anesthesiology, Graduate School of Dental Medicine, Hokkaido University (Japan); Hiraoki, Toshifumi [Division of Applied Physics, Graduate School of Engineering, Hokkaido University (Japan); Kimura, Kunie; Fukushima, Kazuaki [Department of Dental Anesthesiology, Graduate School of Dental Medicine, Hokkaido University (Japan); Suzuki, Kuniaki [Department of Molecular Cell Pharmacology, Graduate School of Dental Medicine, Hokkaido University (Japan)

    2012-12-01

    Highlights: Black-Right-Pointing-Pointer We studied the effects of general anesthetics on liposome using ESR spectra. Black-Right-Pointing-Pointer Two spin labels, 5-DSA and 16-DSA, were located in different position in liposome. Black-Right-Pointing-Pointer Anesthetics did not change the environment around the spin labels in the liposome. Black-Right-Pointing-Pointer Anesthetics remained on the surface of the lipid bilayer of liposome. Black-Right-Pointing-Pointer Proteins in the liposome did not change the effects of anesthetics on liposome. - Abstract: We investigated the effects of general anesthetics on liposome containing spin labels, 5-doxyl stearic acid (5-DSA) and 16-doxyl stearic acid (16-DSA), and purified Na,K-ATPase or membrane protein of microsome using an electron spin resonance (ESR) spectroscopy. The spectra of 16-DSA in liposomes with both proteins showed three sharp signals compared with 5-DSA. The difference in the order parameter S value of 5-DSA and 16-DSA suggested that the nitroxide radical location of 5-DSA and 16-DSA were different in the membrane bilayer. The results were almost the same as those obtained in liposomes without proteins. The addition of sevoflurane, isoflurane, halothane, ether, ethanol and propofol increased the intensity of the signals, but the clinical concentrations of anesthetics did not significantly alter the S and {tau} values, which are indices of the fluidity of the membrane. These results suggest that anesthetics remain on the surface of the lipid bilayer and do not act on both the inside hydrophobic area and the relatively hydrophilic area near the surface. These results and others also suggest that the existence of Na,K-ATPase and microsomal proteins did not affect the environment around the spin labels in the liposome and the effects of anesthetics on liposome as a model membrane.

  14. Generalized requirements and decompositions for the design of test parts for micro additive manufacturing research

    DEFF Research Database (Denmark)

    Thompson, Mary Kathryn; Clemmensen, Line Katrine Harder

    2015-01-01

    level decompositions for the design of test parts and the design of experiments to characterize micro additive manufacturing processes. While the test parts and the experiments described are still work in progress, the generic requirements derived from them can serve as a starting point for the design......The design of experimental test parts to characterize micro additive manufacturing (AM) processes is challenging due to the influence of the manufacturing and metrology processes. This work builds on the lessons learned from a case study in the literature to derive generalized requirements and high...... of other micro additive manufacturing related studies and their decompositions can help structure future work....

  15. SPINAL ANESTHESIA A BETTER AND EFFECTIVE ALTERNATIVE TO GENERAL ANEASTHESIA IN SPINE SURGERIES: A PROSPECTIVE OPEN LABEL SINGLE ARM STUDY

    Directory of Open Access Journals (Sweden)

    Kumar Babu

    2014-11-01

    Full Text Available : INTRODUCTION: In all practical purposes various thoraco lumbar and lumbar surgeries like discectomy, laminectomy and spinal fusion procedures are usually performed under general anesthesia (GA. Our aim of this study is to assess whether spinal anesthesia is a better and effective alternative to general anesthesia in terms of economic advantage and functional recovery with both intra and post-operative heamodynamic stability. METHODS: In our study hundred patients with age group 25-45 yrs within the ASA criteria of class I-III were enrolled. All patients were randomly selected based on age, sex, ASS criteria, duration of surgery, heart rate (HR, mean arterial pressure (MAP, blood loss, previous history of risk factors and co morbidities. The severity of postoperative pain based on visual analogue scale (VAS and use of analgesics post operatively, were recorded. RESULTS: There were 41 males and 59 females. The mean age of the patient was 39.28±9.27 yrs. Six patients had hypertension, 11 with diabetes. Patients with ASA Grade I and II and III were 60, 34 and 6 respectively. There were no episodes of air way compromises, 2 patients had spinal aneasthesia failures, no incidence of post dural puncture headache, 3 patients had mean blood pressure fluctuations among them, one patient had post-operative paraperesis due to hematoma treated by immediate decompression, and 13 patients had usage of propofol sedation in terms of comfort. The duration of surgery (range was 77.25±22.44 min (40-120 Severity of postoperative pain after four hours of surgery on VAS was 3.24±0.46. Twenty two patients (22% required analgesics. Two patients had post-operative vomiting. CONCLUSIONS: In our study we have considered that spinal anesthesia for advantages such as less blood loss, intra operative blood pressure and heart rate changes, postoperative pain, quick functional recovery and lower incidence of pulmonary complications. Additionally, during spinal anesthesia

  16. Generic functional requirements for a NASA general-purpose data base management system

    Science.gov (United States)

    Lohman, G. M.

    1981-01-01

    Generic functional requirements for a general-purpose, multi-mission data base management system (DBMS) for application to remotely sensed scientific data bases are detailed. The motivation for utilizing DBMS technology in this environment is explained. The major requirements include: (1) a DBMS for scientific observational data; (2) a multi-mission capability; (3) user-friendly; (4) extensive and integrated information about data; (5) robust languages for defining data structures and formats; (6) scientific data types and structures; (7) flexible physical access mechanisms; (8) ways of representing spatial relationships; (9) a high level nonprocedural interactive query and data manipulation language; (10) data base maintenance utilities; (11) high rate input/output and large data volume storage; and adaptability to a distributed data base and/or data base machine configuration. Detailed functions are specified in a top-down hierarchic fashion. Implementation, performance, and support requirements are also given.

  17. Perindopril for control of blood pressure in patients with hypertension and other cardiovascular risk factors: an open-label, observational, multicentre, general practice-based study.

    Science.gov (United States)

    Ogilvie, Richard Ian; Anand, Sanjiv; Roy, Pierre; De Souza, Selwyn

    2008-01-01

    Hypertension, one of the major treatable cardiovascular (CV) risk factors, usually occurs in association with other major risk factors. As well as providing rapid blood pressure (BP) goal attainment, antihypertensive therapy should also provide reductions in CV events and mortality in a wide range of patients. For this, higher dosages and combinations of antihypertensive agents are often required. ACE inhibitors are recommended as first-line agents for control of hypertension in patients with additional CV risk factors. The PEACH (Perindopril's Effect At Controlling Hypertension) study was a community-based study performed to evaluate the effectiveness and safety of high-dose perindopril in patients with mild-to-moderate hypertension and additional risk factors for CV disease. This was an open-label, multicentre observational study conducted in Canadian general practice clinics. The study assessed the efficacy and tolerability of perindopril given once daily for 10 weeks uptitrated to the maximal recommended dose of perindopril as required for BP control in newly diagnosed or previously treated patients with uncontrolled mild to moderate hypertension and >or=1 additional risk factor. Patients not achieving target BP after 2 weeks of therapy were uptitrated from perindopril 4 mg to perindopril 8 mg once daily. Efficacy endpoints included reduction in systolic (SBP) and diastolic (DBP) BP and BP control. Tolerability assessments included adverse effects and physicians' assessment of tolerability. The number of missed doses was also recorded. Overall, 2220 patients with hypertension and >or=1 other risk factor were prescribed perindopril at 291 centres; 51.9% were male, 78.3% Caucasian, 12.8% Asian, 36.2%>or=65 years of age and 34.5% had uncontrolled BP despite previous antihypertensive treatment. Compared with previously treated patients, treatment-naive patients had fewer risk factors, and a higher proportion were Asian (prisk factors. Perindopril produced

  18. The Association between Warning Label Requirements and Cigarette Smoking Prevalence by Education-Findings from the Global Adult Tobacco Survey (GATS).

    Science.gov (United States)

    Shang, Ce; Huang, Jidong; Cheng, Kai-Wen; He, Yanyun; Chaloupka, Frank J

    2017-01-21

    The Guidelines for the implementation of Article 11 of the World Health Organization (WHO) Framework Convention on Tobacco Control (FCTC) require that cigarette health warning labels should include pictures and take up 50% or more of the principal display area. This study examined how the association between large pictorial warnings, those covering ≥50% of the front and back of the package, and the prevalence of cigarette smoking varies by educational attainment. We pooled individual-level tobacco use data from the Global Adult Tobacco Survey (GATS) in 18 countries between 2008 and 2013 and linked them with warning label requirements during the same period from the MPOWER database and reports regarding warnings. The respondents' self-reported exposure to warnings was examined according to education. Logistic regressions were further employed to analyze education-specific associations between large pictorial warnings and smoking prevalence, and whether such association differed by education was examined using an interaction test. At the time of the survey, eight out of 18 countries had imposed graphic warning labels that covered ≥50% of the package. These warnings were associated with a 10.0% (OR = 0.89; 95% CI: 0.81, 0.97; p ≤ 0.01) lower cigarette smoking prevalence among adults with less than a secondary education or no formal education, but not among respondents with at least a secondary education. Less educated respondents were also less likely to be exposed to warnings in all 18 countries. The association between strong warnings and lower smoking prevalence among less educated respondents could be greater if their exposure to warnings increases. Prominent pictorial warning labels can potentially reduce health disparities resulting from smoking across different education levels.

  19. General Tritium Labelling of Gentamicin C by catalytic hydrogen exchange Reaction with Tritiated Water; Marcado general con tritio de la Gentamicina C por intercambio catalitico con agua triatiada

    Energy Technology Data Exchange (ETDEWEB)

    Suarez, C.; Diaz, D.; Paz, D.

    1991-07-01

    Gentamicin C was labelled with tritium by means of a PtO2 catalyzed hydrogen exchange reaction. Under the conditions of the exchange (100 mg of gentamicin, basic form, 0,3 ml H2O-3H, and 50 mg of prereduced PtO2) the radiochemical yield was 0,24, 0,38 and 0,48 % at 120 degree celsius, for 8, 16 and 24 hours respectively. Chemical yield for purified gentamicin was about 60 %. Purification was accomplished with a cellulose column eluted with the lower phase of chloroform-methanol 17 % ammonium hydroxide (2:1:1, v/v) . Chemical purity, determined by HPLC, was 96,5 % and radiochemical one was 95. Main exchange degradation products show biological activity. (Author) 12 refs.

  20. Overexpression of biotin synthase and biotin ligase is required for efficient generation of sulfur-35 labeled biotin in E. coli

    Directory of Open Access Journals (Sweden)

    Prigge Sean T

    2010-10-01

    Full Text Available Abstract Background Biotin is an essential enzyme cofactor that acts as a CO2 carrier in carboxylation and decarboxylation reactions. The E. coli genome encodes a biosynthetic pathway that produces biotin from pimeloyl-CoA in four enzymatic steps. The final step, insertion of sulfur into desthiobiotin to form biotin, is catalyzed by the biotin synthase, BioB. A dedicated biotin ligase (BirA catalyzes the covalent attachment of biotin to biotin-dependent enzymes. Isotopic labeling has been a valuable tool for probing the details of the biosynthetic process and assaying the activity of biotin-dependent enzymes, however there is currently no established method for 35S labeling of biotin. Results In this study, we produced [35S]-biotin from Na35SO4 and desthiobiotin with a specific activity of 30.7 Ci/mmol, two orders of magnitude higher than previously published methods. The biotinylation domain (PfBCCP-79 from the Plasmodium falciparum acetyl-CoA carboxylase (ACC was expressed in E. coli as a biotinylation substrate. We found that overexpression of the E. coli biotin synthase, BioB, and biotin ligase, BirA, increased PfBCCP-79 biotinylation 160-fold over basal levels. Biotinylated PfBCCP-79 was purified by affinity chromatography, and free biotin was liberated using acid hydrolysis. We verified that we had produced radiolabeled biologically active [D]-biotin that specifically labels biotinylated proteins through reuptake in E. coli. Conclusions The strategy described in our report provides a simple and effective method for the production of [35S]-biotin in E. coli based on affinity chromatography.

  1. Food labels

    DEFF Research Database (Denmark)

    Selsøe Sørensen, Henrik; Clement, Jesper; Gabrielsen, Gorm

    2012-01-01

    The food industry develops tasty and healthy food but fails to deliver the message to all consumers. The consumers’ background knowledge is essential for how they find and decode relevant elements in the cocktail of signs which fight for attention on food labels. In this exploratory study, we find...... evidence for dividing consumers into two profiles: one relying on general food knowledge and another using knowledge related to signpost labels. In a combined eyetracking and questionnaire survey we analyse the influence of background knowledge and identify different patterns of visual attention...... for the two consumer profiles. This underlines the complexity in choosing and designing the ‘right’ elements for a food package that consumers actually look at and are able to make rational use of. In spite of any regulation of food information provided by authorities, consumers will still be confronted...

  2. Sublinear distance labeling for sparse graphs

    DEFF Research Database (Denmark)

    Alstrup, Stephen; Dahlgaard, Søren; Knudsen, Mathias Bæk Tejs;

    2015-01-01

    between pairs of nodes that are at distance at least $D$ from each other. In this paper we consider distance labeling schemes for the classical case of unweighted and undirected graphs. We present the first distance labeling scheme of size $o(n)$ for sparse graphs (and hence bounded degree graphs......). This addresses an open problem by Gavoille et. al. [J. Algo. 2004], hereby separating the complexity from general graphs which require $\\Omega(n)$ size Moon [Proc. of Glasgow Math. Association 1965]. As an intermediate result we give a $O(\\frac{n}{D}\\log^2 D)$ $D$-preserving distance labeling scheme, improving...

  3. Labeling Schemes with Queries

    OpenAIRE

    2006-01-01

    We study the question of ``how robust are the known lower bounds of labeling schemes when one increases the number of consulted labels''. Let $f$ be a function on pairs of vertices. An $f$-labeling scheme for a family of graphs $\\cF$ labels the vertices of all graphs in $\\cF$ such that for every graph $G\\in\\cF$ and every two vertices $u,v\\in G$, the value $f(u,v)$ can be inferred by merely inspecting the labels of $u$ and $v$. This paper introduces a natural generalization: the notion of $f$-...

  4. A 64-week, multicenter, open-label study of aripiprazole effectiveness in the management of patients with schizophrenia or schizoaffective disorder in a general psychiatric outpatient setting

    Directory of Open Access Journals (Sweden)

    Chiu Nan-Ying

    2010-09-01

    Full Text Available Abstract Objective To evaluate the overall long-term effectiveness of aripiprazole in patients with schizophrenia in a general psychiatric practice setting in Taiwan. Methods This was a prospective, open-label, multicenter, post-market surveillance study in Taiwanese patients with a Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV diagnosis of schizophrenia or schizoaffective disorder requiring a switch in antipsychotic medication because current medication was not well tolerated and/or clinical symptoms were not well controlled. Eligible patients were titrated to aripiprazole (5-30 mg/day over a 12-week switching phase, during which their previous medication was discontinued. Patients could then enter a 52-week, long-term treatment phase. Aripiprazole was flexibly dosed (5-30 mg/day at the discretion of the treating physicians. Efficacy was assessed using the Clinical Global Impression scale Improvement (CGI-I score, the Clinical Global Impression scale Severity (CGI-S score, The Brief Psychiatry Rating Scale (BPRS, and the Quality of Life (QOL scale, as well as Preference of Medicine (POM ratings by patients and caregivers. Safety and tolerability were also assessed. Results A total of 245 patients were enrolled and switched from their prior antipsychotic medications, and 153 patients entered the 52-week extension phase. In all, 79 patients (32.2% completed the study. At week 64, the mean CGI-I score was 3.10 and 64.6% of patients who showed response. Compared to baseline, scores of CGI-S, QOL, and BPRS after 64 weeks of treatment also showed significant improvements. At week 12, 65.4% of subjects and 58.9% of caregivers rated aripiprazole as better than the prestudy medication on the POM. The most frequently reported adverse events (AEs were headache, auditory hallucinations and insomnia. A total of 13 patients (5.3% discontinued treatment due to AEs. No statistically significant changes were noted with respect to

  5. 9 CFR 317.8 - False or misleading labeling or practices generally; specific prohibitions and requirements for...

    Science.gov (United States)

    2010-01-01

    ... percent of the length (longest dimension) of the representative slice, and this window shall be at least... top or bottom edge of a 1-pound or smaller package and not more than three-fourths inch from either... transparent window shall be designed to reveal at least 70 percent of the length (longest dimension) of...

  6. Food Labels

    Science.gov (United States)

    ... Surgery? Choosing the Right Sport for You Shyness Food Labels KidsHealth > For Teens > Food Labels Print A ... have at least 95% organic ingredients. continue Making Food Labels Work for You The first step in ...

  7. General practitioners knowledge, practice and training requirements in relation to doping in sport.

    Science.gov (United States)

    Woods, C B; Moynihan, A

    2009-01-01

    This study examined General Practitioner's (GP) knowledge, practice and training requirements in relation to doping in sport in Ireland. All 2083 GPs on the Irish College of General Practitioners (ICGP) register received a postal questionnaire, yielding a 37% response rate (N=771, 63% male, average age 46.2 +/- 9SD, range 28-74 years). Results revealed that 14% (112) deemed their knowledge of doping agents to be good or very good, 12% (94) had completed specific training modules in doping or sport, and 24% (183) were connected with a specific sport as a team doctor/advisor. Over one in four (28%: 217) had been consulted for advice on doping in Sport, 33% (256) possessed the current list of prohibited substances, and 25% (190) knew of the Irish Sports Council's drug-testing procedures. The current initiatives to discourage doping in sport were felt to be ineffective, and although 92% (716) indicated that GPs had a role to play in the prevention of doping in sport, only 9% (66) felt adequately trained for such a role. There was overwhelming support for further training among GPs, although the most appropriate method of providing training is complex and requires strategic planning.

  8. 40 CFR 91.113 - Requirement of certification-emission control information label and engine identification number.

    Science.gov (United States)

    2010-07-01

    ... MARINE SPARK-IGNITION ENGINES Emission Standards and Certification Provisions § 91.113 Requirement of... during engine life; (4) Be written in English; and (5) Be located so as to be readily visible to the average person after the engine is installed in the marine vessel. (b) If the marine vessel obscures...

  9. 21 CFR 201.26 - Exceptions or alternatives to labeling requirements for human drug products held by the Strategic...

    Science.gov (United States)

    2010-04-01

    ... requirements for human drug products held by the Strategic National Stockpile. 201.26 Section 201.26 Food and... drug products held by the Strategic National Stockpile. (a) The appropriate FDA Center Director may... lots, batches, or other units of a human drug product that are or will be held in the...

  10. 21 CFR 610.60 - Container label.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 7 2010-04-01 2010-04-01 false Container label. 610.60 Section 610.60 Food and... GENERAL BIOLOGICAL PRODUCTS STANDARDS Labeling Standards § 610.60 Container label. (a) Full label. The following items shall appear on the label affixed to each container of a product capable of bearing a...

  11. General Approach for Introduction of Various Chemical Labels in Specific RNA Locations Based on Insertion of Amino Linkers

    Directory of Open Access Journals (Sweden)

    Dmitri Graifer

    2013-11-01

    Full Text Available Introduction of reporter groups at designed RNA sites is a widely accepted approach to gain information about the molecular environment of RNAs in their complexes with other biopolymers formed during various cellular processes. A general approach to obtain RNAs bearing diverse reporter groups at designed locations is based on site-specific insertion of groups containing primary aliphatic amine functions (amino linkers with their subsequent selective derivatization by appropriate chemicals. This article is a brief review on methods for site-specific introduction of amino linkers in different RNAs. These methods comprise: (i incorporation of a nucleoside carrying an amino-linker or a function that can be substituted with it into oligoribonucleotides in the course of their chemical synthesis; (ii assembly of amino linker-containing RNAs from short synthetic fragments via their ligation; (iii synthesis of amino linker-modified RNAs using T7 RNA polymerase; (iv insertion of amino linkers into unmodified RNAs at functional groups of a certain type such as the 5'-phosphates and N7 of guanosine residues and (v introduction of an amino linker into long highly structured RNAs exploiting an approach based on sequence-specific modification of nucleic acids. Particular reporter groups used for derivatization of amino linker-containing RNAs together with types of RNA derivatives obtained and fields of their application are presented.

  12. 21 CFR 201.71 - Magnesium labeling.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Magnesium labeling. 201.71 Section 201.71 Food and... LABELING Labeling Requirements for Over-the-Counter Drugs § 201.71 Magnesium labeling. (a) The labeling of over-the-counter (OTC) drug products intended for oral ingestion shall contain the magnesium...

  13. General university requirements and holistic development in university students in Hong Kong.

    Science.gov (United States)

    Shek, Daniel T L; Yu, Lu

    2017-02-01

    The General University Requirements (GUR) at The Hong Kong Polytechnic University (PolyU) is an integral part of the new 4-year undergraduate curriculum which attempts to promote holistic student development. To evaluate the effectiveness of the GUR, a study adopting a static group comparison design was conducted, with a sample of Year 3 PolyU students studied in the 4-year undergraduate degree program (n=566) compared with a control Year 3 sample recruited from a comparable university in Hong Kong (n=285). The students in both samples responded to measures on empathy, positive youth development, and engagement in university study. Results showed that although both groups basically did not differ in the major background demographic variables, PolyU students performed better than did the students of the control group on measures of holistic development. Bearing in mind the intrinsic problems of the static comparison group design, the present findings provide support for the effectiveness of the GUR at PolyU.

  14. Exigências de lisina digestível para aves de corte da linhagem ISA Label criadas em semiconfinamento Digestible lysine requirements for ISA Label broilers reared in free-range system

    Directory of Open Access Journals (Sweden)

    D.C. Nagib Nascimento

    2009-10-01

    Full Text Available Foram realizados três experimentos para determinar as exigências de lisina digestível para aves da linhagem ISA Label, de ambos os sexos, criadas em semiconfinamento durante as fases: inicial (1 a 28 dias, de crescimento (28 a 56 dias e final (56 a 84 dias. Em cada experimento, foram utilizadas 480 aves, alojadas em 24 piquetes, cada um contendo abrigo coberto de 3,13m² e área de pastejo de 72,87m². O delineamento experimental utilizado foi o inteiramente ao acaso, em esquema fatorial 4x2 (níveis de lisina e sexo com três repetições de 20 aves cada. Os níveis de lisina digestível avaliados foram: 0,850; 0,970; 1,090 e 1,210% na fase inicial; 0,750; 0,870; 0,990 e 1,110% na fase de crescimento e 0,640; 0,760; 0,880 e 1,000% na fase final. Foram mensuradas as variáveis de desempenho, característica de carcaça, deposição de proteína e gordura corporal, peso e teor de proteína das penas. Com base nos resultados de desempenho, recomendam-se 1, 041; 1,006 e 0,760% de lisina digestível em rações para aves ISA Label nas fases inicial, de crescimento e final, respectivamente.Three assays were carried out to determine digestible lysine requirement for ISA Label, both genders, in free-range system on starter (1 to 28 days, growing (28 to 56 days e finishing phases (56 to 84 days. A total of 480 birds were distributed into 24 pens, each one composed by shelter (3.13m² and pasture (72.87m². The experimental design was a completely randomized in factorial arrangement (four levels of lysine and two genders with three replicates of 20 birds. The digestible lysine levels were 0.85, 0.97, 1.09, and 1.21% for starter; 0.75, 0.87, 0.99, and 1.11% for growing; and 0.64, 0.76, 0.88, and 1.00% for finishing phases. The analyzed parameters were performance, carcass yield, protein and fat deposition, weight, and protein in the feathers. Based on bird performance the estimated digestible lysine level, was 1.041, 1.006, and 0.760% for the starter

  15. 17 CFR 147.3 - General requirement of open meetings; grounds upon which meetings may be closed.

    Science.gov (United States)

    2010-04-01

    ... COMMODITY FUTURES TRADING COMMISSION OPEN COMMISSION MEETINGS § 147.3 General requirement of open meetings... including, but not limited to: (A) Reports of stocks of grain, such as Forms 38, 38C, 38M and 38T, required... memoranda and work-product concerning examinations and other inquiries or investigations and...

  16. 29 CFR 785.5 - General requirements of sections 6 and 7 of the Fair Labor Standards Act.

    Science.gov (United States)

    2010-07-01

    ... the Fair Labor Standards Act. Section 6 requires the payment of a minimum wage by an employer to his... 29 Labor 3 2010-07-01 2010-07-01 false General requirements of sections 6 and 7 of the Fair Labor Standards Act. 785.5 Section 785.5 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR DIVISION...

  17. ECOLOGICAL CERTIFICATION AND LABELLING OF TOURIST SERVICES

    Directory of Open Access Journals (Sweden)

    Mirela Stefanica

    2013-12-01

    Full Text Available This work presents an analysis of ecological certification and labelling in the field of tourism. In a tourist company, the certification schemes evaluate the general approach of environmental problems, and impose to the tourist services the observance of pre-established principles and guiding lines concerning the environment. They become for the tourist companies a behavioural standard in the development of their activity. The requirements within such schemes are often flexible and open to interpretation, and generally less controversial than the eco-labelling schemes. As compared to the certification schemes, the eco-labels attributed to the tourist services emphasise the impact over the environment of the services of tourist companies, on the basis of certain European criteria. These criteria refer to the whole life cycle of these tourist services.

  18. 42 CFR 84.1157 - Chemical cartridge respirators with particulate filters; performance requirements; general.

    Science.gov (United States)

    2010-10-01

    ... APPROVAL OF RESPIRATORY PROTECTIVE DEVICES Dust, Fume, and Mist; Pesticide; Paint Spray; Powered Air... following minimum requirements for performance and protection: (a) Breathing resistance test. (1) Resistance...) The maximum allowable resistance requirements for chemical cartridge respirators are as...

  19. Legalization: Phase Two Requirements and Guidelines for Courses of Study Recognized by the Attorney General.

    Science.gov (United States)

    Immigration and Naturalization Service, Washington, DC. Office of Outreach.

    Information concerning the federal regulations governing the basic citizenship skills requirement for immigrant legalization, as amended, is presented. Materials include: (1) a sample memorandum to educational service providers relaying information concerning the requirement; (2) revised requirements and guidelines for courses of study recognized…

  20. Multi-iPPseEvo: A Multi-label Classifier for Identifying Human Phosphorylated Proteins by Incorporating Evolutionary Information into Chou's General PseAAC via Grey System Theory.

    Science.gov (United States)

    Qiu, Wang-Ren; Zheng, Quan-Shu; Sun, Bi-Qian; Xiao, Xuan

    2017-03-01

    Predicting phosphorylation protein is a challenging problem, particularly when query proteins have multi-label features meaning that they may be phosphorylated at two or more different type amino acids. In fact, human protein usually be phosphorylated at serine, threonine and tyrosine. By introducing the "multi-label learning" approach, a novel predictor has been developed that can be used to deal with the systems containing both single- and multi-label phosphorylation protein. Here we proposed a predictor called Multi-iPPseEvo by (1) incorporating the protein sequence evolutionary information into the general pseudo amino acid composition (PseAAC) via the grey system theory, (2) balancing out the skewed training datasets by the asymmetric bootstrap approach, and (3) constructing an ensemble predictor by fusing an array of individual random forest classifiers thru a voting system. Rigorous cross-validations via a set of multi-label metrics indicate that the multi-label phosphorylation predictor is very promising and encouraging. The current approach represents a new strategy to deal with the multi-label biological problems, and the software is freely available for academic use at http://www.jci-bioinfo.cn/Multi-iPPseEvo.

  1. 99mTc: Labeling Chemistry and Labeled Compounds

    Science.gov (United States)

    Alberto, R.; Abram, U.

    This chapter reviews the radiopharmaceutical chemistry of technetium related to the synthesis of perfusion agents and to the labeling of receptor-binding biomolecules. To understand the limitations of technetium chemistry imposed by future application of the complexes in nuclear medicine, an introductory section analyzes the compulsory requirements to be considered when facing the incentive of introducing a novel radiopharmaceutical into the market. Requirements from chemistry, routine application, and market are discussed. In a subsequent section, commercially available 99mTc-based radiopharmaceuticals are treated. It covers the complexes in use for imaging the most important target organs such as heart, brain, or kidney. The commercially available radiopharmaceuticals fulfill the requirements outlined earlier and are discussed with this background. In a following section, the properties and perspectives of the different generations of radiopharmaceuticals are described in a general way, covering characteristics for perfusion agents and for receptor-specific molecules. Technetium chemistry for the synthesis of perfusion agents and the different labeling approaches for target-specific biomolecules are summarized. The review comprises a general introduction to the common approaches currently in use, employing the N x S4-x , [3+1] and 2-hydrazino-nicotinicacid (HYNIC) method as well as more recent strategies such as the carbonyl and the TcN approach. Direct labeling without the need of a bifunctional chelator is briefly reviewed as well. More particularly, recent developments in the labeling of concrete targeting molecules, the second generation of radiopharmaceuticals, is then discussed and prominent examples with antibodies/peptides, neuroreceptor targeting small molecules, myocardial imaging agents, vitamins, thymidine, and complexes relevant to multidrug resistance are given. In addition, a new approach toward peptide drug development is described. The section

  2. 40 CFR 53.3 - General requirements for an equivalent method determination.

    Science.gov (United States)

    2010-07-01

    ..., performance, and comparability requirements specified for Class III FEMs for PM10−2.5 in subpart C of this part. (6) ISO 9001. All designated FEMs for PM2.5 or PM10−2.5 must be manufactured in an ISO 9001... automated FEMs must have been shown in accordance with this part to satisfy the applicable requirements...

  3. 40 CFR 158.1050 - Post-application exposure-general requirements.

    Science.gov (United States)

    2010-07-01

    ...) PESTICIDE PROGRAMS DATA REQUIREMENTS FOR PESTICIDES Human Exposure § 158.1050 Post-application exposure... requirements if the data meet the basic quality assurance, quality control, good laboratory practice, and other scientific needs of EPA. In order to be acceptable, among other things, the Agency must find that the...

  4. Nutrition Labeling

    DEFF Research Database (Denmark)

    Grunert, Klaus G

    2013-01-01

    because consumers will avoid products that the label shows to be nutritionally deficient, but also because food producers will try to avoid marketing products that appear, according to the label, as nutritionally problematic, for example, because of a high content of saturated fat or salt. Nutrition......Nutrition labeling refers to the provision of information on a food product’s nutritional content on the package label. It can serve both public health and commercial purposes. From a public health perspective, the aim of nutrition labeling is to provide information that can enable consumers...... to make healthier choices when choosing food products. Nutrition labeling is thus closely linked to the notion of the informed consumer, that chooses products according to their aims, on the basis of the information at their disposal. Because many consumers are assumed to be interested in making healthy...

  5. Nutrition Labeling

    DEFF Research Database (Denmark)

    Grunert, Klaus G

    2013-01-01

    because consumers will avoid products that the label shows to be nutritionally deficient, but also because food producers will try to avoid marketing products that appear, according to the label, as nutritionally problematic, for example, because of a high content of saturated fat or salt. Nutrition......Nutrition labeling refers to the provision of information on a food product’s nutritional content on the package label. It can serve both public health and commercial purposes. From a public health perspective, the aim of nutrition labeling is to provide information that can enable consumers...... to make healthier choices when choosing food products. Nutrition labeling is thus closely linked to the notion of the informed consumer, that chooses products according to their aims, on the basis of the information at their disposal. Because many consumers are assumed to be interested in making healthy...

  6. Physical environment. [environmental impact statement required for general aviation airport construction

    Science.gov (United States)

    1975-01-01

    Environmental legislation affecting airports and the more common environmental effects resulting from airport construction are discussed with special emphasis on general aviation airports. The discussion is focused on the regulation of noise, pollution, and water quality.

  7. 40 CFR 112.7 - General requirements for Spill Prevention, Control, and Countermeasure Plans.

    Science.gov (United States)

    2010-07-01

    ... discharges; discharge procedure protocols; applicable pollution control laws, rules, and regulations; general... described in § 112.1(b) that are the result of natural disasters, acts of war or terrorism); and...

  8. Adjunctive levetiracetam in children, adolescents, and adults with primary generalized seizures: Open-label, noncomparative, multicenter, long-term follow-up study.

    LENUS (Irish Health Repository)

    Delanty, Norman

    2012-02-01

    Purpose: To evaluate the long-term efficacy and tolerability of adjunctive levetiracetam (LEV) in patients with uncontrolled idiopathic generalized epilepsy (IGE). Methods: This phase III, open-label, long-term, follow-up study (N167; NCT00150748) enrolled patients (4 to <65 years) with primary generalized seizures (tonic-clonic, myoclonic, absence). Patients received adjunctive LEV at individualized doses (1,000-4,000 mg\\/day; 20-80 mg\\/kg\\/day for children\\/adolescents weighing <50 kg). Efficacy results are reported for all seizure types [intention-to-treat (ITT) population, N = 217] and subpopulations with tonic-clonic (n = 152), myoclonic (n = 121), and\\/or absence (n = 70) seizures at baseline. Key Findings: One hundred twenty-five (57.6%) of 217 patients were still receiving treatment at the end of the study. Mean (standard deviation, SD) LEV dose was 2,917.5 (562.9) mg\\/day. Median (Q1-Q3) exposure to LEV was 2.1 (1.5-2.8) years, and the maximum duration was 4.6 years. Most patients were taking one (124\\/217, 57.1%) or >\\/=2 (92\\/217, 42.4%) concomitant antiepileptic drugs (AEDs). Seizure freedom of >\\/=6 months (all seizure types; primary efficacy end point) was achieved by 122 (56.2%) of 217 patients, and 49 (22.6%) of 217 patients had complete seizure freedom. Seizure freedom of >\\/=6 months from tonic-clonic, myoclonic, and absence seizures was achieved by 95 (62.5%) of 152, 75 (62.0%) of 121, and 44 (62.9%) of 70 patients, respectively. Mean (SD) maximum seizure freedom duration was 371.7 (352.4) days. At least one treatment-emergent adverse event (TEAE) was reported by 165 (76%) of 217 patients; most TEAEs were mild\\/moderate in severity, with no indication of an increased incidence over time. Seventeen (7.8%) of 217 patients discontinued medication because of TEAEs. The most common psychiatric TEAEs were depression (16\\/217, 7.4%), insomnia (9\\/217, 4.1%), nervousness (8\\/217, 3.7%), and anxiety (7\\/217, 3.2%). Significance: Adjunctive

  9. Intimate terrorism and situational couple violence in general surveys: ex-spouses required.

    Science.gov (United States)

    Johnson, Michael P; Leone, Janel M; Xu, Yili

    2014-02-01

    In this article, we argue that past efforts to distinguish among types of intimate partner violence in general survey data have committed a critical error--using data on current spouses to develop operationalizations of intimate terrorism and situational couple violence. We use ex-spouse data from the National Violence Against Women Survey (NVAWS) to develop new operationalizations. We then demonstrate that NVAWS current spouse data contain little intimate terrorism; we argue that this is likely to be the case for all general surveys. In addition, the ex-spouse data confirm past findings regarding a variety of differences between intimate terrorism and situational couple violence, including those predicted by feminist theories.

  10. Stereoselective synthesis of stable-isotope-labeled amino acids

    Energy Technology Data Exchange (ETDEWEB)

    Unkefer, C.J.; Martinez, R.A.; Silks, L.A. III [Los Alamos National Laboratory, NM (United States); Lodwig, S.N. [Centralia College, WA (United States)

    1994-12-01

    For magnetic resonance and vibrational spectroscopies to reach their full potential, they must be used in combination with sophisticated site-specific stable isotope labeling of biological macromolecules. Labeled amino acids are required for the study of the structure and function of enzymes and proteins. Because there are 20 common amino acids, each with its own distinguishing chemistry, they remain a synthetic challenge. The Oppolzer chiral auxiliary provides a general tool with which to approach the synthesis of labeled amino acids. By using the Oppolzer auxiliary, amino acids can be constructed from several small molecules, which is ideal for stable isotope labeling. In addition to directing the stereochemistry at the {alpha}-carbon, the camphorsultam can be used for stereo-specific isotope labeling at prochiral centers in amino acids. By using the camphorsultam auxiliary we have the potential to synthesize virtually any isotopomer of all of the common amino acids.

  11. 42 CFR 84.159 - Man tests for gases and vapors; supplied-air respirators; general performance requirements.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Man tests for gases and vapors; supplied-air respirators; general performance requirements. 84.159 Section 84.159 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE...

  12. 21 CFR 312.40 - General requirements for use of an investigational new drug in a clinical investigation.

    Science.gov (United States)

    2010-04-01

    ... new drug in a clinical investigation. 312.40 Section 312.40 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) DRUGS FOR HUMAN USE INVESTIGATIONAL NEW DRUG APPLICATION Administrative Actions § 312.40 General requirements for use of an investigational new drug in...

  13. 78 FR 64237 - Information Collection: General and Oil and Gas Production Requirements in the Outer Continental...

    Science.gov (United States)

    2013-10-28

    ... balance the protection and development of OCS resources. Specifically, we use the information collected to...) (electronic/digital form submittals). Subtotal 3,514 responses 3,514 $162,750 non-hour cost burden Compliance... Bureau of Ocean Energy Management Information Collection: General and Oil and Gas Production...

  14. 78 FR 77557 - Releasing Information; General Provisions; Accounting and Reporting Requirements; Reports of...

    Science.gov (United States)

    2013-12-24

    ..., 618, and 621 RIN 3052-AC76 Releasing Information; General Provisions; Accounting and Reporting.... We will publish a notice of effective date in the Federal Register. Compliance Date: All provisions... the Act's provisions.\\2\\ Our regulations, including this final rule, are intended to ensure the...

  15. How competent do graduates feel to undertake the skills required by the General Medical Council?

    Science.gov (United States)

    Watmough, Simon; Kennedy, Tom

    2014-08-01

    The General Medical Council outlines the skills medical students are meant to learn as undergraduates. This article summarizes how competent some foundation year one doctors from one deanery felt to undertake these skills, what had prepared them and what they would like more training on.

  16. Sustainability Labeling

    NARCIS (Netherlands)

    Dam, van Y.K.

    2017-01-01

    Sustainability labeling originated from a need to protect the identity of alternative systems of food production and to increase market transparency. From the 1980s onwards sustainability labeling has changed into a policy instrument replacing direct government regulation of the food market, and a

  17. 76 FR 36890 - Clarification of Prior Interpretations of the Seat Belt and Seating Requirements for General...

    Science.gov (United States)

    2011-06-23

    ... Federal Aviation Administration 14 CFR Part 91 Clarification of Prior Interpretations of the Seat Belt and... clarify prior interpretations of the seat belt and seating requirements of 14 CFR 91.107(a)(3). These... clarification states that the use of a seat belt and/or seat by more than one occupant is appropriate only...

  18. 77 FR 30885 - Clarification of Prior Interpretations of the Seat Belt and Seating Requirements for General...

    Science.gov (United States)

    2012-05-24

    ... Administration 14 CFR Part 91 [Docket No. FAA-2011-0628] Clarification of Prior Interpretations of the Seat Belt... interpretations of FAA's seat belt and seating requirements. These prior interpretations state that the shared use of a single restraint may be permissible. This clarification states that the use of a seat belt...

  19. 40 CFR 63.11173 - What are my general requirements for complying with this subpart?

    Science.gov (United States)

    2010-07-01

    ... operation with annual usage of more than one ton of MeCl must maintain a copy of their current MeCl... conveyors and parts to pass through the booth during the coating process. (iv) Mobile ventilated enclosures... section. (1) A list of all current personnel by name and job description who are required to be trained...

  20. 49 CFR 192.367 - Service lines: General requirements for connections to main piping.

    Science.gov (United States)

    2010-10-01

    ... connections to main piping. 192.367 Section 192.367 Transportation Other Regulations Relating to... (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF NATURAL AND OTHER GAS BY PIPELINE: MINIMUM FEDERAL SAFETY... requirements for connections to main piping. (a) Location. Each service line connection to a main must...

  1. 40 CFR 270.14 - Contents of part B: General requirements.

    Science.gov (United States)

    2010-07-01

    ... water supplies; (iv) Mitigate effects of equipment failure and power outages; (v) Prevent undue exposure... required by § 264.14, or a justification demonstrating the reasons for requesting a waiver of this... for this reason must instead submit sufficient information to establish a compliance...

  2. 36 CFR 1222.26 - What are the general recordkeeping requirements for agency programs?

    Science.gov (United States)

    2010-07-01

    ... NATIONAL ARCHIVES AND RECORDS ADMINISTRATION RECORDS MANAGEMENT CREATION AND MAINTENANCE OF FEDERAL RECORDS... series; and (e) Policies, procedures, and strategies for ensuring that records are retained long enough... recordkeeping requirements that identify: (a) The record series and systems that must be created and...

  3. 47 CFR 2.1203 - General requirement for entry into the U.S.A.

    Science.gov (United States)

    2010-10-01

    ... may be imported into the Customs territory of the United States unless the importer or ultimate consignee, or their designated customs broker, declares that the device meets one of the conditions for... for consumption, required redelivery to the Customs port, and other administrative, civil and...

  4. 13 CFR 108.600 - General requirement for NMVC Company to maintain and preserve records.

    Science.gov (United States)

    2010-01-01

    ..., asset valuations, liabilities, equity, income, and expenses. (ii) Your Articles, bylaws, minute books... supporting documentation (such as vouchers, bank statements, or canceled checks) for the records listed in... requirements set forth in Circular A-110 of the Office of Management and Budget. (OMB circulars are...

  5. 49 CFR 172.302 - General marking requirements for bulk packagings.

    Science.gov (United States)

    2010-10-01

    ... permanently installed on a tube trailer motor vehicle, on each side and each end of the motor vehicle. (b... rail cars; (2) Have a width of at least 4.0 mm (0.16 inch) and a height of at least 25 mm (one inch...) Additional requirements for marking portable tanks, cargo tanks, tank cars, multi-unit tank car tanks,...

  6. Development and Assessment of the Effectiveness of an Undergraduate General Education Foreign Language Requirement

    Science.gov (United States)

    Thompson, Robert J., Jr.; Walther, Ingeborg; Tufts, Clare; Lee, Kunshan Carolyn; Paredes, Liliana; Fellin, Luciana; Andrews, Edna; Serra, Matt; Hill, Jennifer L.; Tate, Eleanor B.; Schlosberg, Laura

    2014-01-01

    This article describes a faculty-led, multiyear process of formulating learning objectives and assessing the effectiveness of a foreign language requirement for all College of Arts and Sciences undergraduates at a research university. Three interrelated research questions were addressed: (1) What were the levels and patterns of language courses…

  7. General laws of competition duel and universal requirements to technical-tactic fitness of elite wrestlers

    Directory of Open Access Journals (Sweden)

    Korobeynikov G.V.

    2016-02-01

    Full Text Available Purpose: to determine and formulate general technical-tactic laws (rules of competition duel in modern free style wrestling. Material: competition functioning of free style wrestlers at Olympic Games has been analyzed. Results of authors’ own pedagogic observations and advanced experience of free style wrestling specialists have been generalized. Results: it was found that victory in duel can be resulted only from attacking tactic of duel. It was determined that wrestlers’ activity (quantity of actual attacks in unit of time varies from 1 to 2.2 attacks per minute. Reliability of attack (ratio of quantity of assessed attacks to quantity of actually fulfilled attacks is within 0.33-0.63. Reliability of defense (ratio of quantity of successfully repelled opponent’s attacks to general quantity of his actual attacks is from 0.55-0.78. Efficiency of fighting in stance is within 0.6-1.3 points per minute. Efficiency of ground fighting is 1.3-2.3 points per minute. Conclusions: coach shall bring the formulated laws in compliance with specificity of his functioning and consider them, when planning training process of junior wrestlers.

  8. 21 CFR 606.121 - Container label.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 7 2010-04-01 2010-04-01 false Container label. 606.121 Section 606.121 Food and... Container label. (a) The container label requirements are designed to facilitate the use of a uniform container label for blood and blood components (except Source Plasma) by all blood establishments. (b)...

  9. Requirements for tolerances in a CAM-I generalized, solid geometric modeling system

    Energy Technology Data Exchange (ETDEWEB)

    Easterday, R.J.

    1980-01-01

    For a geometric modeling system to support computer-assisted manufacturing, it is necessary that dimensioning and tolerancing information be available in computer-readable form. The requirements of a tolerancing scheme within a geometric modeling system are discussed; they include structure sufficient to characterize the tolerance specifications currently in use by industry, means to associate tolerance structures to the boundary representation, means to create and edit information in the tolerance structures, means to extract information from the data base, and functions to check for completeness and validity of the tolerances. 1 figure, 8 tables. (RWR)

  10. Revocation of General Safety Test Regulations That Are Duplicative of Requirements in Biologics License Applications. Final rule.

    Science.gov (United States)

    2015-07-02

    The Food and Drug Administration (FDA) is amending the biologics regulations by removing the general safety test (GST) requirements for biological products. FDA is finalizing this action because the existing codified GST regulations are duplicative of requirements that are also specified in biologics license applications (BLAs), or are no longer necessary or appropriate to help ensure the safety, purity, and potency of licensed biological products. FDA is taking this action as part of its retrospective review of its regulations to promote improvement and innovation, in response to the Executive order.

  11. Generalized peritonitis requiring re-operation after leakage of omental patch repair of perforated peptic ulcer

    Directory of Open Access Journals (Sweden)

    Hemmat Maghsoudi

    2011-01-01

    Full Text Available Background/Aim: Peptic ulcer perforations are a common emergency, but available literature is silent on the exact definition, incidence, management, and complications of peritonitis due to omental patch leakage. Patients and Methods: Retrospective data were collected on 422 patients who underwent omental patch repair of perforated peptic ulcer between March 20, 1999 and March 20, 2006. The definitive diagnosis of perforated peptic ulcer and omental patch leakage was obtained at surgery. Results: Seventeen (4% patients experienced generalized peritonitis due to omental patch leakage. Mean age was 60.6 years. Mortality rate was 29.4%, and the mean hospital stay was 23.6 days. Delay in surgical approach, shock on admission, and age were all significantly associated with increased mortality. Conclusions: Peritonitis due to omental patch leakage can result in significant morbidity and mortality. The most common causes of omental patch leakage and operative procedures were unknown and reinsertion of omentum, respectively. Factors such as shock on admission or delayed surgery, have significantly contributed to fatal outcomes and need careful attention.

  12. How to Read a Nutrition Facts Label

    Medline Plus

    Full Text Available ... General Health Growth & Development Infections Diseases & Conditions Pregnancy & ... leer las etiquetas de datos nutricionales (video) Most packaged foods come with a Nutrition Facts label. These labels ...

  13. Sustainability labels on food products

    DEFF Research Database (Denmark)

    Grunert, Klaus G; Hieke, Sophie; Wills, Josephine

    2014-01-01

    This study investigates the relationship between consumer motivation, understanding and use of sustainability labels on food products (both environmental and ethical labels), which are increasingly appearing on food products. Data was collected by means of an online survey implemented in the UK......, human values as measured by the Schwartz value domains, and country differences. The results imply that sustainability labels currently do not play a major role in consumers’ food choices, and future use of these labels will depend on the extent to which consumers’ general concern about sustainability...

  14. Semantic Role Labeling

    CERN Document Server

    Palmer, Martha; Xue, Nianwen

    2011-01-01

    This book is aimed at providing an overview of several aspects of semantic role labeling. Chapter 1 begins with linguistic background on the definition of semantic roles and the controversies surrounding them. Chapter 2 describes how the theories have led to structured lexicons such as FrameNet, VerbNet and the PropBank Frame Files that in turn provide the basis for large scale semantic annotation of corpora. This data has facilitated the development of automatic semantic role labeling systems based on supervised machine learning techniques. Chapter 3 presents the general principles of applyin

  15. Qualitative evaluation of general university requirements in a new 4-year university curriculum: findings based on experiences of students.

    Science.gov (United States)

    Shek, Daniel T L; Yu, Lu; Wu, Florence K Y; Ng, Catalina S M; Chai, Wen Yu

    2017-02-01

    Following the North American model, the length of undergraduate program in Hong Kong has been extended from 3 to 4 years since 2012. To maximize the impact of the additional year, The Hong Kong Polytechnic University (PolyU) has implemented a new general education framework entitled "General University Requirements (GUR)" aiming to cultivate students in a holistic manner. This study explored students' impressions of the GUR subjects using a survey collecting primarily qualitative data. Results from 163 students of eight faculties showed that students perceived the GUR subjects favorably. Having opportunities to make new friends from other departments and the teaching and learning methods, particularly experiential learning stimulated students' interest and enriched their learning experiences which were reportedly are unforgettable. Some of the obstacles encountered by students in several subjects were identified. The beneficial effects of the GUR subjects in different domains were voiced by the students.

  16. 21 CFR 1230.13 - Labeling of “poison”.

    Science.gov (United States)

    2010-04-01

    ... FEDERAL CAUSTIC POISON ACT Labeling § 1230.13 Labeling of “poison”. The following are styles of...-point size are required on a label in stating the word “poison” they must not be smaller than...

  17. Compliance towards dispensed medication labelling standards: a cross-sectional study in the state of Penang, Malaysia.

    Science.gov (United States)

    Neoh, Chin Fen; Hassali, Mohamed Azmi; Shafie, Asrul Akmal; Awaisu, Ahmed; Tambyappa, Jayabalan

    2009-09-01

    Good medicine labelling practice is vital to ensure safe use of medicines. Non-compliance to labelling standards is a potential source of medication errors. This study was intended to evaluate and compare compliance towards labelling standard for dispensed medications between community pharmacists and general practitioners in Penang, Malaysia. A total of 128 community pharmacies and 26 general practitioners' clinics were visited. Using 'Simulated Client Method' (SCM), data were collected on the medications dispensed upon presentation of hypothetical common cold symptoms. The medications dispensed were evaluated for labelling adequacy. Result revealed that majority of the dispensed medications obtained were not labelled according to regulatory requirements. However, general practitioners complied better than community pharmacists in terms of labelling for: name of patient (p<0.001), details of supplier (p<0.001), dosage of medication (p=0.023), frequency to take medication (p=0.023), patient's reference number (p<0.001), date of supply (p<0.001), special instructions for medication (p=0.008), storage requirements (p=0.002), and indication for medication (p<0.001). Conversely, community pharmacists labelled dispensed medications with the words "Controlled Medicine" more often than did general practitioners (p<0.001). Although laws for labelling dispensed medicines are in place, most community pharmacists and general practitioners did not comply accordingly, thereby putting patients' safety at risks of medication errors.

  18. 14 CFR 1263.107 - Procedure to be followed when response to a demand is required before the General Counsel or...

    Science.gov (United States)

    2010-01-01

    ... demand is required before the General Counsel or designate has reached a final decision. If a response to... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Procedure to be followed when response to a demand is required before the General Counsel or designate has reached a final decision. 1263.107...

  19. Synthesis of [1-{sup 11}C]octanoic acid, [{sup 11}C]raclopride and [{sup 11}C]nicergoline with a general-purpose automated synthesis apparatus of {sup 11}C-labeled radiopharmaceuticals

    Energy Technology Data Exchange (ETDEWEB)

    Yajima, Kazuyosi; Kawashima, Hidefumi; Cui, Ying-she; Hashimoto, Naoto; Miyake, Yoshihiro [National Cardiovascular Center, Suita, Osaka (Japan)

    1997-06-01

    We have developed a general-purpose automated synthesis apparatus of {sup 11}C-labeled radiopharmaceuticals for PET, which can be adopted to both one-pot and two-or-more-pot reactions. The features of the apparatus were shown in the successful preparation of [(1-{sup 11})C]octanoic acid in a one-pot reaction and [{sup 11}C]raclopride and [{sup 11}C]nicergoline in two-pot reactions, the latter being a novel radiopharmaceutical. (author).

  20. Should Excessive Worry Be Required for a Diagnosis of Generalized Anxiety Disorder? Results from the US National Comorbidity Survey Replication

    Science.gov (United States)

    Ruscio, Ayelet Meron; Lane, Michael; Roy-Byrne, Peter; Stang, Paul E.; Stein, Dan J.; Wittchen, Hans-Ulrich; Kessler, Ronald C.

    2007-01-01

    Background Excessive worry is required by DSM-IV, but not ICD-10, for a diagnosis of generalized anxiety disorder (GAD). No large-scale epidemiological study has ever examined the implications of this requirement for estimates of prevalence, severity, or correlates of GAD. Methods Data were analyzed from the US National Comorbidity Survey Replication, a nationally representative, face-to-face survey of adults in the US household population that was fielded in 2001–2003. DSM-IV GAD was assessed with Version 3.0 of the WHO Composite International Diagnostic Interview. Non-excessive worriers meeting all other DSM-IV criteria for GAD were compared with respondents who met full GAD criteria as well as with other survey respondents to consider the implications of removing the excessiveness requirement. Results The estimated lifetime prevalence of GAD increases by approximately 40% when the excessiveness requirement is removed. Excessive GAD begins earlier in life, has a more chronic course, and is associated with greater symptom severity and psychiatric comorbidity than non-excessive GAD. However, non-excessive cases nonetheless evidence substantial persistence and impairment of GAD as well as significantly elevated comorbidity compared to respondents without GAD. Non-excessive cases also have socio-demographic characteristics and familial aggregation of GAD comparable to excessive cases. Conclusions Although individuals who meet all criteria for GAD other than excessiveness have a somewhat milder presentation than those with excessive worry, their syndromes are sufficiently similar to those with excessive worry to warrant a GAD diagnosis. PMID:16300690

  1. The impact of nutritional labels and socioeconomic status on energy intake. An experimental field study.

    Science.gov (United States)

    Crockett, Rachel A; Jebb, Susan A; Hankins, Matthew; Marteau, Theresa M

    2014-10-01

    There is some evidence for paradoxical effects of nutritional labelling on energy intake particularly amongst restrained eaters and those with a higher body mass index (BMI) resulting in greater consumption of energy from foods with a positive health message (e.g. "low-fat") compared with the same foods, unlabelled. This study aimed to investigate, in a UK general population sample, the likelihood of paradoxical effects of nutritional labelling on energy intake. Participants (n = 287) attended a London cinema and were offered a large tub of salted or toffee popcorn. Participants were randomised to receive their selected flavour with one of three labels: a green low-fat label, a red high-fat label or no label. Participants watched two film clips while completing measures of demographic characteristics, emotional state and taste of the popcorn. Following the experiment, popcorn consumption was measured. There were no main effects of nutritional labelling on consumption. Contrary to predictions neither BMI nor weight concern moderated the effect of label on consumption. There was a three-way interaction between low-fat label, weight concern and socioeconomic status (SES) such that weight-concerned participants of higher SES who saw a low-fat label consumed more than weight unconcerned participants of similar SES (t = -2.7, P = .04). By contrast, weight-concerned participants of lower SES seeing either type of label, consumed less than those seeing no label (t = -2.04, P = .04). Nutritional labelling may have different effects in different socioeconomic groups. Further studies are required to understand fully the possible contribution of food labelling to health inequalities.

  2. Nutrition labelling: a review of research on consumer and industry response in the global South

    Directory of Open Access Journals (Sweden)

    Jessie Mandle

    2015-01-01

    Full Text Available Background: To identify peer-reviewed research on consumers’ usage and attitudes towards the nutrition label and the food industry's response to labelling regulations outside Europe, North America, and Australia and to determine knowledge gaps for future research. Design: Narrative review. Results: This review identified nutrition labelling research from 20 countries in Asia, Africa, the Middle East, and Latin America. Consumers prefer that pre-packaged food include nutrition information, although there is a disparity between rates of use and comprehension. Consumer preference is for front-of-pack labelling and for information that shows per serving or portion as a reference unit, and label formats with graphics or symbols. Research on the food and beverage industry's response is more limited but shows that industry plays an active role in influencing legislation and regulation. Conclusions: Consumers around the world share preferences with consumers in higher income countries with respect to labelling. However, this may reflect the research study populations, who are often better educated than the general population. Investigation is required into how nutrition labels are received in emerging economies especially among the urban and rural poor, in order to assess the effectiveness of labelling policies. Further research into the outlook of the food and beverage industry, and also on expanded labelling regulations is a priority. Sharing context-specific research regarding labelling between countries in the global South could be mutually beneficial in evaluating obesity prevention policies and strategies.

  3. 99mTechnetium-labelled red blood cell scintigraphy as an alternative to angiography in the investigation of gastrointestinal bleeding: clinical experience in a district general hospital.

    Science.gov (United States)

    Bearn, P.; Persad, R.; Wilson, N.; Flanagan, J.; Williams, T.

    1992-01-01

    99mTechnetium-labelled red blood cell scintigraphy (99mTc RBC scintigraphy) was used as the second-line investigation to localise bleeding in 23 patients (11 male, 12 female; mean age 67 years) presenting with active bleeding per rectum. Scintigraphy was available on a 24 h basis. A total of 18 patients had positive scans (78%). Surgery was performed urgently in 11 patients and the site of bleeding, as predicted by scintigraphy, was confirmed in 9 (82%). 99mTc RBC scintigraphy was less useful in patients who were not bleeding actively or who were being investigated for chronic anaemia. This study suggests that 99mTc RBC scintigraphy can play a useful role in the preoperative localisation of unexplained gastrointestinal bleeding in hospitals with nuclear medicine facilities, but confirms it has little place in the management of patients unless they are bleeding actively. PMID:1319696

  4. Introduction to Pesticide Labels

    Science.gov (United States)

    Pesticide product labels provide critical information about how to safely and legally handle and use pesticide products. Unlike most other types of product labels, pesticide labels are legally enforceable. Learn about pesticide product labels.

  5. Food Label and You

    Medline Plus

    Full Text Available ... Products Food Home Food Ingredients, Packaging & Labeling Labeling & Nutrition The Food Label and You — Video Share Tweet ... FDA has issued final changes to update the Nutrition Facts label for packaged foods. For more information, ...

  6. A COMPARATIVE EVALUATION OF GABAPENTIN AND CLONIDINE PREMEDICATION ON POST OPERATIVE ANALGESIA REQUIREMENT FOLLOWING ABDOMINAL SURGERIES UNDER GENERAL ANAESTHESIA

    Directory of Open Access Journals (Sweden)

    Ashish

    2014-08-01

    Full Text Available AIM: Aim of our study was to compare the relative effectiveness of gabapentin and clonidine premedication on patients undergoing elective abdominal surgeries under G.A. OBJECTIVE: gabapentine and clonidine have anti-nociceptive properties .This study assess their efficacy in prolonging the analgesic effect intra-operative and postoperative analgesic requirement. MATERIAL AND METHOD: 225 patients of either sex of age between 20-60 years, ASA grade I & II, patient admitted to Hamidia hospital for elective abdominal surgeries under general anaesthesia were included in the study. The patients were randomly allocated into three groups 75 each group I : Control group (patients received placebo tablet at 90 min before the surgery,group II Gabapentin 300 mg tablet orally 90 min before surgery ,groupIII:clonidine150µg tablet orally given 90 min before surgery. Duration of postoperative analgesia, Degree of postoperative pain (VAS scoreand added rescue analgesia required in 24 hrs were recorded postoperatively. RESULT: Analysis reveled that there was no difference in the HR, SBP among the three group during the study. Duration of postoperative analgesia, observed from time of reversal to first demand of analgesia in the recovery room was more in group II compared to group I and group III (p-value <0.001, highly significant. Pain perception was highly blunted in groups II compared to group I & group III. Total rescue analgesic requirement during the postoperative 24hrs period was much lower in group II inj Diclofenac compared to group I and group III . ( p-value < 0.001, highly significant.CONCLUSION: Given 90 min before induction of GA oral gabapentin(300 mg or clonidine(150 µg preoperatively was effective in lowering postoperative VAS pain score and consumption of analgesics, it was also shows that gabapentin significantly decreases postoperative pain intensity and analgesic consumption after abdominal surgeries.

  7. Food quality labels from the producers’ perspective

    Directory of Open Access Journals (Sweden)

    Šárka Velčovská

    2016-09-01

    Full Text Available The paper deals with analysing the food producer attitudes towards quality labels. The Klasa label, as the most known and the most frequently used food quality label in the Czech Republic, have become the subject of investigation. The aim of the research was to identify the benefits and problems arising from the certification process and the label use. Primary data were collected in online survey based on standardized questionnaire. In census, 86 respondents from the total 218 producers with the Klasa label in the Czech Republic completed the questionnaire. The most of producers (72% have a longer experience with the label, they are using the label for more than four years. The producers’ expectations from the label were fulfilled only partially. A poor state marketing support and missing marketing strategy were identified as general problems of the label. Specific perceived problems are formalities connected with the certification process and certification of poor-quality products. Correlation analysis, t-test and Pearson chi-square test were calculated to discover relations between variables. The results of the study can be beneficial to both, food producers as well as administrator of the label. Identified problems could help them to improve marketing strategy of the label in order to manage the label in effective way and use all benefits arising from the certification. Administrator of the label should make the certification process more effective and transparent, promotion should be focused on the explanation to consumers what the Klasa label guarantees.

  8. On Online Labeling with Polynomially Many Labels

    DEFF Research Database (Denmark)

    Babka, Martin; Bulánek, Jan; Cunat, Vladimír

    2012-01-01

    In the online labeling problem with parameters n and m we are presented with a sequence of nkeys from a totally ordered universe U and must assign each arriving key a label from the label set {1,2,…,m} so that the order of labels (strictly) respects the ordering on U. As new keys arrive it may be...

  9. “You don't immediately stick a label on them”: a qualitative study of influences on general practitioners' recording of anxiety disorders

    Science.gov (United States)

    Ford, Elizabeth; Campion, Alice; Chamles, Darleen Aixora; Habash-Bailey, Haniah; Cooper, Maxwell

    2016-01-01

    Objectives Anxiety is a common condition usually managed in general practice (GP) in the UK. GP patient records can be used for epidemiological studies of anxiety as well as clinical audit and service planning. However, it is not clear how general practitioners (GPs) conceptualise, diagnose and document anxiety in these records. We sought to understand these factors through an interview study with GPs. Setting UK National Health Service (NHS) General Practice (England and Wales). Participants 17 UK GPs. Primary and secondary outcome measures Semistructured interviews used vignettes to explore the process of diagnosing anxiety in primary care and investigate influences on recording. Interviews were transcribed verbatim and analysed using thematic analysis. Results GPs chose 12 different codes for recording anxiety in the 2 vignettes, and reported that history, symptoms and management would be recorded in free text. GPs reported on 4 themes representing influences on recording of anxiety: ‘anxiety or a normal response’, ‘granularity of diagnosis’, ‘giving patients a label’ and ‘time as a tool’; and 3 themes about recording in general: ‘justifying the choice of code’, ‘usefulness of coding’ and ‘practice-specific pressures’. GPs reported using only a regular selection of codes in patient records to help standardise records within the practice and as a time-saving measure. Conclusions We have identified a coding culture where GPs feel confident recognising anxiety symptoms; however, due to clinical uncertainty, a long-term perspective and a focus on management, they are reluctant to code firm diagnoses in the initial stages. Researchers using GP patient records should be aware that GPs may prefer free text, symptom codes and other general codes rather than firm diagnostic codes for anxiety. PMID:27338879

  10. New labels for radiation therapy

    Energy Technology Data Exchange (ETDEWEB)

    Kubota, Susumu; Mukai, Minoru; Kato, Hirotoshi (National Inst. of Radiological Sciences, Chiba (Japan))

    1992-12-01

    In simulating radiotherapy, the bone and trachea identified by plain X-P and the other organs, such as the esophagus and bladder, outlined by contrast medium have so far been used as labels. However, irradiation with a high therapeutic ratio is required for an intracorporeal insertion of artificial labels that are identified by X-ray fluoroscopy. For this purpose, metal clips and seed dummies are available, although they cause artifacts in CT scans. Therefore, the authors are using an acupuncture needle and lipiodol for tracing as new artificial labels, since both are identified by X-ray fluoroscopy and CT scan and create few artifacts. (J.P.N.).

  11. PR NF EN 12975-1 Thermal solar systems and components - collectors - Part. 1: general requirements; Installations solaires thermiques et leurs composants. Capteurs solaires. Partie 1: exigences generales

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2004-08-01

    The document specifies requirements on durability (including mechanical strength), reliability and safety for liquid heating solar collectors. It also includes provisions for evaluation of conformity to these requirements. It is not applicable to those collectors in which the thermal storage unit is an integral part of the collector to such an extent, that the collection process cannot be separated from the storage process for the purpose of making measurements of those two processes. It is not applicable to tracking concentrating solar collectors. (author)

  12. 21 CFR 226.80 - Packaging and labeling.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Packaging and labeling. 226.80 Section 226.80 Food...: GENERAL CURRENT GOOD MANUFACTURING PRACTICE FOR TYPE A MEDICATED ARTICLES Packaging and Labeling § 226.80 Packaging and labeling. (a) Packaging and labeling operations shall be adequately controlled: (1) To...

  13. A Study on Standards System of Chinese Environmental Labeling Program

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    @@ Implementing Outlines for the Chinese Environmental Labeling Program By awarding certificates and labels to related manufacturers in accordance with certain environmental labeling standards, environmental labeling,also called "Green Label"or "Eco-label", certifies via governmental departments or public and private organizations that the whole process of producing,using, recalling and disposing of manufacturers'products is in compliance with certain environmental requirements. Many countries are establishing and promoting environmental labeling plans. Environmental labeling, as an important promotion means for prevention and control of pollution in a market-oriented manner, is being extended and developed constantly across the world.

  14. The topology of metabolic isotope labeling networks

    Directory of Open Access Journals (Sweden)

    Wiechert Wolfgang

    2007-08-01

    Full Text Available Abstract Background Metabolic Flux Analysis (MFA based on isotope labeling experiments (ILEs is a widely established tool for determining fluxes in metabolic pathways. Isotope labeling networks (ILNs contain all essential information required to describe the flow of labeled material in an ILE. Whereas recent experimental progress paves the way for high-throughput MFA, large network investigations and exact statistical methods, these developments are still limited by the poor performance of computational routines used for the evaluation and design of ILEs. In this context, the global analysis of ILN topology turns out to be a clue for realizing large speedup factors in all required computational procedures. Results With a strong focus on the speedup of algorithms the topology of ILNs is investigated using graph theoretic concepts and algorithms. A rigorous determination of all cyclic and isomorphic subnetworks, accompanied by the global analysis of ILN connectivity is performed. Particularly, it is proven that ILNs always brake up into a large number of small strongly connected components (SCCs and, moreover, there are natural isomorphisms between many of these SCCs. All presented techniques are universal, i.e. they do not require special assumptions on the network structure, bidirectionality of fluxes, measurement configuration, or label input. The general results are exemplified with a practically relevant metabolic network which describes the central metabolism of E. coli comprising 10390 isotopomer pools. Conclusion Exploiting the topological features of ILNs leads to a significant speedup of all universal algorithms for ILE evaluation. It is proven in theory and exemplified with the E. coli example that a speedup factor of about 1000 compared to standard algorithms is achieved. This widely opens the door for new high performance algorithms suitable for high throughput applications and large ILNs. Moreover, for the first time the global

  15. The general transcriptional repressor Tup1 is required for dimorphism and virulence in a fungal plant pathogen.

    Directory of Open Access Journals (Sweden)

    Alberto Elías-Villalobos

    2011-09-01

    Full Text Available A critical step in the life cycle of many fungal pathogens is the transition between yeast-like growth and the formation of filamentous structures, a process known as dimorphism. This morphological shift, typically triggered by multiple environmental signals, is tightly controlled by complex genetic pathways to ensure successful pathogenic development. In animal pathogenic fungi, one of the best known regulators of dimorphism is the general transcriptional repressor, Tup1. However, the role of Tup1 in fungal dimorphism is completely unknown in plant pathogens. Here we show that Tup1 plays a key role in orchestrating the yeast to hypha transition in the maize pathogen Ustilago maydis. Deletion of the tup1 gene causes a drastic reduction in the mating and filamentation capacity of the fungus, in turn leading to a reduced virulence phenotype. In U. maydis, these processes are controlled by the a and b mating-type loci, whose expression depends on the Prf1 transcription factor. Interestingly, Δtup1 strains show a critical reduction in the expression of prf1 and that of Prf1 target genes at both loci. Moreover, we observed that Tup1 appears to regulate Prf1 activity by controlling the expression of the prf1 transcriptional activators, rop1 and hap2. Additionally, we describe a putative novel prf1 repressor, named Pac2, which seems to be an important target of Tup1 in the control of dimorphism and virulence. Furthermore, we show that Tup1 is required for full pathogenic development since tup1 deletion mutants are unable to complete the sexual cycle. Our findings establish Tup1 as a key factor coordinating dimorphism in the phytopathogen U. maydis and support a conserved role for Tup1 in the control of hypha-specific genes among animal and plant fungal pathogens.

  16. The extended-release formulation of quetiapine fumarate (quetiapine XR) adjunctive treatment in partially responsive generalized anxiety disorder (GAD): An open label naturalistic study.

    Science.gov (United States)

    Gabriel, A

    2011-01-01

    To assess the effect of adjunctive treatment with extended-release formulation of quetiapine fumarate (quetiapine XR) to other antidepressants in the treatment of partially responsive, poorly functioning patients with generalized anxiety disorder was assessed. Twenty four consenting adult outpatients with confirmed DSM-IV diagnosis of generalized disorder were identified. All patients failed at least one 8-week treatment trial with SSRI or SNRI antidepressant. All were treated with quetiapine XR as an add on treatment to citalopram or vanlafaxine antidepressant for at least 12 weeks. The primary efficacy measure was the Clinical Global Impression Scale (CGI-S). Other scales included; the Hamilton Anxiety Scale (HAM-A) scale, Sheehan Disability Scale, and the Abnormal Involuntary Movement Scale (AIMS). Baseline measures prior to adding quetiapine XR were compared to those at 4, 8 and 12 weeks with the adjunctive treatment. Twenty three patients completed the trial. There was significant rapid resolution of the anxiety symptoms in all effectiveness measures, including the symptoms of anxiety as shown by changes from baseline in HAM-A, and CGI at four weeks. Improvement was maintained to week twelve. Impairments in work, social, and home responsibilities were also reduced significantly, and there were no significant changes in weight at 12 weeks. Patients tolerated the adjunctive treatment well. Quetiapine XR may have anxiolytic properties and could be used effectively as adjunctive treatment with SSRIs in GAD patients with partial response to SSRs or SNRISs. However double blind randomized trials are needed to support these results.

  17. 49 CFR 172.429 - POISON INHALATION HAZARD label.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false POISON INHALATION HAZARD label. 172.429 Section... REQUIREMENTS, AND SECURITY PLANS Labeling § 172.429 POISON INHALATION HAZARD label. (a) Except for size and color, the POISON INHALATION HAZARD label must be as follows: ER22JY97.023 (b) In addition to...

  18. Food Label and You

    Medline Plus

    Full Text Available ... Vaccines, Blood & Biologics Animal & Veterinary Cosmetics Tobacco Products Food Home Food Ingredients, Packaging & Labeling Labeling & Nutrition The Food Label and You — Video Share Tweet Linkedin Pin ...

  19. New Ideas on Labeling Schemes

    DEFF Research Database (Denmark)

    Rotbart, Noy Galil

    evaluation of fully dynamic labeling schemes. Due to a connection between adjacency labeling schemes and the graph theoretical study of induced universal graphs, we study these in depth and show novel results for bounded degree graphs and power-law graphs. We also survey and make progress on the related......With ever increasing size of graphs, many distributed graph systems emerged to store, preprocess and analyze them. While such systems ease up congestion on servers, they incur certain penalties compared to centralized data structure. First, the total storage required to store a graph...... in a distributed fashion increases. Second, attempting to answer queries on vertices of a graph stored in a distributed fashion can be significantly more complicated. In order to lay theoretical foundations to the first penalty mentioned a large body of work concentrated on labeling schemes. A labeling scheme...

  20. 78 FR 12676 - Timing Requirements for the Submission of a Site Assessment Plan (SAP) or General Activities Plan...

    Science.gov (United States)

    2013-02-25

    ... Submission of a Site Assessment Plan (SAP) or General Activities Plan (GAP) for a Renewable Energy Project on... Assessment Plan (SAP) or General Activities Plan (GAP) pursuant to the regulations governing renewable energy... lessee or grantee must submit a SAP or a GAP. BOEM is taking this action because the current regulations...

  1. Deep Label Distribution Learning With Label Ambiguity

    Science.gov (United States)

    Gao, Bin-Bin; Xing, Chao; Xie, Chen-Wei; Wu, Jianxin; Geng, Xin

    2017-06-01

    Convolutional Neural Networks (ConvNets) have achieved excellent recognition performance in various visual recognition tasks. A large labeled training set is one of the most important factors for its success. However, it is difficult to collect sufficient training images with precise labels in some domains such as apparent age estimation, head pose estimation, multi-label classification and semantic segmentation. Fortunately, there is ambiguous information among labels, which makes these tasks different from traditional classification. Based on this observation, we convert the label of each image into a discrete label distribution, and learn the label distribution by minimizing a Kullback-Leibler divergence between the predicted and ground-truth label distributions using deep ConvNets. The proposed DLDL (Deep Label Distribution Learning) method effectively utilizes the label ambiguity in both feature learning and classifier learning, which help prevent the network from over-fitting even when the training set is small. Experimental results show that the proposed approach produces significantly better results than state-of-the-art methods for age estimation and head pose estimation. At the same time, it also improves recognition performance for multi-label classification and semantic segmentation tasks.

  2. Extending Modal Transition Systems with Structured Labels

    DEFF Research Database (Denmark)

    Bauer, Sebastian S.; Juhl, Line; Larsen, Kim Guldstrand

    2012-01-01

    We introduce a novel formalism of label-structured modal transition systems that combines the classical may/must modalities on transitions with structured labels that represent quantitative aspects of the model. On the one hand, the specification formalism is general enough to include models like...... study modal and thorough refinement, determinization, parallel composition, conjunction, quotient, and logical characterization of label-structured modal transition systems....

  3. Child Care: State Efforts To Enforce Safety and Health Requirements. United States General Accounting Office Report to Congressional Requesters.

    Science.gov (United States)

    Fagnoni, Cynthia M.

    Although states must certify that they have requirements to protect the health and safety of children in child care in order to receive Child Care and Development Block Grant funds, neither the scope nor stringency of these requirements has been stipulated. At the request of Congressional members, this report identifies the most critical…

  4. Pharmaceutical preparation of oxygen-15 labelled molecular oxygen and carbon monoxide gasses in a hospital setting.

    NARCIS (Netherlands)

    Luurtsema, Geert; Boellaard, Ronald; Greuter, Henri; Rijbroek, Abraham; Takkenkamp, Kevin; de Geest, Frank; Buijs, Fred; Hendrikse, NH; Franssen, Eric; van Lingen, Arthur; Lammertsma, Adriaan A.

    2010-01-01

    BACKGROUND: Clinical positron emission tomography (PET) requires safe and effective PET radiopharmaceuticals. Tracers used for measuring oxygen consumption and blood volume are [(15)O]O(2) and [(15)O]CO, respectively. In general, these oxygen-15 labelled tracers are produced using a cyclotron that a

  5. Optimal methyl labeling for studies of supra-molecular systems

    Energy Technology Data Exchange (ETDEWEB)

    Religa, Tomasz L.; Kay, Lewis E., E-mail: kay@pound.med.utoronto.c [The University of Toronto, Departments of Molecular Genetics, Biochemistry and Chemistry (Canada)

    2010-07-15

    Selective methyl labeling combined with HMQC spectroscopy that exploits a TROSY effect in {sup 13}CH{sub 3} spin systems has significantly extended the utility of solution NMR spectroscopy in studies of high molecular weight particles. Herein we compare the utility of {sup 13}CH{sub 3}- versus {sup 13}CHD{sub 2}-labeling of Ile, Leu, Val probes in supra-molecular systems through quantification of relative signal-to-noise ratios in optimized spectra of highly deuterated, {sup 13}CH{sub 3}- and {sup 13}CHD{sub 2}-labeled samples of the half proteasome ({alpha}{sub 7}{alpha}{sub 7}, 360 kDa). It is shown that the sensitivity of spectra recorded on Ile, Leu, Val {sup 13}CH{sub 3}-labeled samples is between 1.5 and 2 fold higher than the corresponding data sets obtained on {alpha}{sub 7}{alpha}{sub 7} with {sup 13}CHD{sub 2} probes. Thus, labeling of supra-molecules with {sup 13}CH{sub 3} isotopomers remains the method of choice, but in applications where {sup 13}CHD{sub 2} moieties are required, sensitivity will in general not be limiting.

  6. Efficacy and safety of ixekizumab treatment for Japanese patients with moderate to severe plaque psoriasis, erythrodermic psoriasis and generalized pustular psoriasis: Results from a 52-week, open-label, phase 3 study (UNCOVER-J).

    Science.gov (United States)

    Saeki, Hidehisa; Nakagawa, Hidemi; Nakajo, Ko; Ishii, Taeko; Morisaki, Yoji; Aoki, Takehiro; Cameron, Gregory S; Osuntokun, Olawale O

    2017-04-01

    Psoriasis, a chronic, immune-mediated skin disease characterized by red, scaly plaques, affects approximately 0.3% of the population in Japan. The aim of this open-label study was to evaluate the long-term efficacy and safety of ixekizumab, a humanized, anti-interleukin-17A monoclonal antibody, in Japanese patients with plaque psoriasis (n = 78, including 11 psoriatic arthritis), erythrodermic psoriasis (n = 8) and generalized pustular psoriasis (n = 5). Ixekizumab was administrated s.c. at baseline (week 0, 160 mg), from weeks 2 to 12 (80 mg every 2 weeks), and from weeks 16 to 52 (80 mg every 4 weeks). At week 52, 92.3% of patients with plaque psoriasis achieved Psoriasis Area and Severity Index (PASI) 75, 80.8% achieved PASI 90, 48.7% achieved PASI 100, and 52.6% had remission of plaques (by static Physician Global Assessment, sPGA [0]). Difficult to treat areas of psoriasis (nail or scalp) also responded to ixekizumab. All patients with psoriatic arthritis who were assessed (5/5) achieved an American College of Rheumatology 20 response. Most patients with erythrodermic psoriasis or generalized pustular psoriasis responded to ixekizumab and the clinical outcome was maintained over 52 weeks (75% and 60% of patients achieved sPGA [0, 1] at week 52, respectively). Mostly mild or moderate treatment-emergent adverse events were reported by 79 of 91 patients; the most common were nasopharyngitis, eczema, seborrheic dermatitis, urticaria and injection site reactions. In conclusion, 52-week ixekizumab treatment was efficacious and well tolerated in Japanese patients with plaque psoriasis. Efficacy was also observed in patients with erythrodermic psoriasis, generalized pustular psoriasis and psoriatic arthritis. © 2016 Eli Lilly Japan K.K. The Journal of Dermatology published by John Wiley & Sons Australia, Ltd on behalf of Japanese Dermatological Association.

  7. The anatomy of a laser label

    Science.gov (United States)

    Laser labeling of fruits and vegetables is an efficient alternative to adhesive tags. The advantages of this system are numerous. In general the label consists of alphanumerical characters formed by laser generated pinhole depressions that penetrate the produce’s surface creating visible markings. H...

  8. 7 CFR 65.400 - Labeling.

    Science.gov (United States)

    2010-01-01

    ... AGRICULTURAL MARKETING ACT OF 1946 AND THE EGG PRODUCTS INSPECTION ACT (CONTINUED) COUNTRY OF ORIGIN LABELING..., PEANUTS, AND GINSENG General Provisions Country of Origin Notification § 65.400 Labeling. (a) Country of... country of origin of a product may be in the form of a statement such as “Product of USA,” “Produce of the...

  9. Monitoring and control requirement definition study for dispersed storage and generation (DSG). Volume II. Final report, Appendix A: selected DSG technologies and their general control requirements

    Energy Technology Data Exchange (ETDEWEB)

    1980-10-01

    A major aim of the US National Energy Policy, as well as that of the New York State Energy Research and Development Authority, is to conserve energy and to shift from oil to more abundant domestic fuels and renewable energy sources. Dispersed Storage and Generation (DSG) is the term that characterizes the present and future dispersed, relatively small (<30 MW) energy systems, such as solar thermal electric, photovoltaic, wind, fuel cell, storage battery, hydro, and cogeneration, which can help achieve these national energy goals and can be dispersed throughout the distribution portion of an electric utility system. The purpose of this survey and identification of DSG technologies is to present an understanding of the special characteristics of each of these technologies in sufficient detail so that the physical principles of their operation and the internal control of each technology are evident. In this way, a better appreciation can be obtained of the monitoring and control requirements for these DSGs from a remote distribution dispatch center. A consistent approach is being sought for both hardware and software which will handle the monitoring and control necessary to integrate a number of different DSG technologies into a common distribution dispatch network. From this study it appears that the control of each of the DSG technologies is compatible with a supervisory control method of operation that lends itself to remote control from a distribution dispatch center.

  10. Policy and the Impact on Placement, Involvement, and Progress in General Education: Critical Issues That Require Rectification

    Science.gov (United States)

    Ryndak, Diane Lea; Taub, Debbie; Jorgensen, Cheryl M.; Gonsier-Gerdin, Jean; Arndt, Katrina; Sauer, Janet; Ruppar, Andrea L.; Morningstar, Mary E.; Allcock, Heather

    2014-01-01

    Students with significant disabilities continue to be among the most segregated in schools. In this article, we argue that the principles of least restrictive environment and involvement and progress in the general curriculum have been interpreted in ways that perpetuate segregation, rather than increasing students' access to meaningful…

  11. Qualitative assessment of general movements in high-risk preterm infants with chronic lung disease requiring dexamethasone therapy

    NARCIS (Netherlands)

    Bos, AF; Martijn, A; van Asperen, RM; Hadders-Algra, M; Okken, A; Prechtl, HFR

    1998-01-01

    Objective: The objective of this study was to determine in preterm infants al risk for severe chronic lung disease (1) the quality of general movements (GMs) and (2) the effect of dexamethasone treatment on spontaneous motor activity. Study design: In 15 very low birth weight infants the quality of

  12. To Explore the Quality System for Medical Equipment Labels and Packaging Requirements%质量体系对医疗器械标签、说明书和包装的要求探究

    Institute of Scientific and Technical Information of China (English)

    吕宏光

    2014-01-01

    Briefly introduce the Quality system control requirement to label and packaging of Medical Device quality system regulation from SFDA, U.S.FDA, and ISO13485:2003 international standard, And simply compare and analyse the sameness and differentia among these quality system regulation and standard. To facilitate medical device Manufacturer comprehensively consider these requirement when planning and implementation of Medical device quality system.%本文概括性地介绍了中国、美国医疗器械质量体系法规和ISO13485:2003标准对医疗器械标签、说明书和包装的控制要求,从质量体系的角度分析了对医疗器械标签、标识和包装的控制,从形式和内容方面比较了这些要求的异同,便于医疗器械制造商在实施质量体系时进行全面的考量。

  13. Psychological effectiveness of carbon labelling

    Science.gov (United States)

    Beattie, Geoffrey

    2012-04-01

    Despite the decision by supermarket-giant Tesco to delay its plan to add carbon-footprint information onto all of its 70,000 products, carbon labelling, if carefully designed, could yet change consumer behaviour. However, it requires a new type of thinking about consumers and much additional work.

  14. 78 FR 2200 - Energy Labeling Rule

    Science.gov (United States)

    2013-01-10

    ... ensure consumers can view the labels when they are shopping online. In particular, it will provide retail... From the Federal Register Online via the Government Publishing Office FEDERAL TRADE COMMISSION 16..., clarifying testing requirements and enforcement provisions, improving online energy label disclosures, and...

  15. Alternatives to radioimmunoassay: labels and methods

    Energy Technology Data Exchange (ETDEWEB)

    Schall, R.F. Jr.; Tenoso, H.J.

    1981-07-01

    The following labels used as substitutes for radioisotopes in immunoassay systems are reviewed bacteriophages, chemiluminescence precursors, fluorochromes, fluorogens, fluorescence quenchers, enzymes, coenzymes, inhibitors, substrates, various particulates, metal atoms, and stable free radicals. New methods for performing immunoassays with these labels are described where appropriate. Methods that require no separation steps and offer special promise for easy automation are noted. 69 references cited.

  16. Understanding the role of mirror neurons in action understanding will require more than a domain-general account.

    Science.gov (United States)

    Martin, Alia; Santos, Laurie R

    2014-04-01

    Cook et al. propose that mirror neurons emerge developmentally through a domain-general associative mechanism. We argue that experience-sensitivity does not rule out an adaptive or genetic argument for mirror neuron function, and that current evidence suggests that mirror neurons are more specialized than the authors' account would predict. We propose that future work integrate behavioral and neurophysiological techniques used with primates to examine the proposed functions of mirror neurons in action understanding.

  17. How to Read a Nutrition Facts Label

    Medline Plus

    Full Text Available ... KidsHealth from Nemours for Parents for Kids for Teens Search Parents Home General Health Growth & Development Infections ... labels so you can make healthy choices. For Teens For Kids For Parents MORE ON THIS TOPIC ...

  18. Matching isotopic distributions from metabolically labeled samples.

    Science.gov (United States)

    McIlwain, Sean; Page, David; Huttlin, Edward L; Sussman, Michael R

    2008-07-01

    In recent years stable isotopic labeling has become a standard approach for quantitative proteomic analyses. Among the many available isotopic labeling strategies, metabolic labeling is attractive for the excellent internal control it provides. However, analysis of data from metabolic labeling experiments can be complicated because the spacing between labeled and unlabeled forms of each peptide depends on its sequence, and is thus variable from analyte to analyte. As a result, one generally needs to know the sequence of a peptide to identify its matching isotopic distributions in an automated fashion. In some experimental situations it would be necessary or desirable to match pairs of labeled and unlabeled peaks from peptides of unknown sequence. This article addresses this largely overlooked problem in the analysis of quantitative mass spectrometry data by presenting an algorithm that not only identifies isotopic distributions within a mass spectrum, but also annotates matches between natural abundance light isotopic distributions and their metabolically labeled counterparts. This algorithm is designed in two stages: first we annotate the isotopic peaks using a modified version of the IDM algorithm described last year; then we use a probabilistic classifier that is supplemented by dynamic programming to find the metabolically labeled matched isotopic pairs. Such a method is needed for high-throughput quantitative proteomic metabolomic experiments measured via mass spectrometry. The primary result of this article is that the dynamic programming approach performs well given perfect isotopic distribution annotations. Our algorithm achieves a true positive rate of 99% and a false positive rate of 1% using perfect isotopic distribution annotations. When the isotopic distributions are annotated given 'expert' selected peaks, the same algorithm gets a true positive rate of 77% and a false positive rate of 1%. Finally, when annotating using machine selected peaks, which

  19. Production of isotopically labeled heterologous proteins in non-E. coli prokaryotic and eukaryotic cells.

    Science.gov (United States)

    Takahashi, Hideo; Shimada, Ichio

    2010-01-01

    The preparation of stable isotope-labeled proteins is necessary for the application of a wide variety of NMR methods, to study the structures and dynamics of proteins and protein complexes. The E. coli expression system is generally used for the production of isotope-labeled proteins, because of the advantages of ease of handling, rapid growth, high-level protein production, and low cost for isotope-labeling. However, many eukaryotic proteins are not functionally expressed in E. coli, due to problems related to disulfide bond formation, post-translational modifications, and folding. In such cases, other expression systems are required for producing proteins for biomolecular NMR analyses. In this paper, we review the recent advances in expression systems for isotopically labeled heterologous proteins, utilizing non-E. coli prokaryotic and eukaryotic cells.

  20. Active and Reserve Unit Costs: DOD Report to Congress Generally Addressed the Statutory Requirements but Lacks Detail

    Science.gov (United States)

    2014-07-31

    National Defense Authorization Act for Fiscal Year 2012, Section 1080A, issued in January 2012, states that such reductions must be balanced with...preparation for future challenges and protection of the broad range of U.S. national security interests. One key to achieving this balance is determining the...addressed the statutory requirements, we used a scorecard methodology in which two analysts independently assessed the extent to which the report’s

  1. Substrate Recognition by the Cdh1 Destruction Box Receptor Is a General Requirement for APC/CCdh1-mediated Proteolysis.

    Science.gov (United States)

    Qin, Liang; Guimarães, Dimitrius Santiago P S F; Melesse, Michael; Hall, Mark C

    2016-07-22

    The anaphase-promoting complex, or cyclosome (APC/C), is a ubiquitin ligase that selectively targets proteins for degradation in mitosis and the G1 phase and is an important component of the eukaryotic cell cycle control system. How the APC/C specifically recognizes its substrates is not fully understood. Although well characterized degron motifs such as the destruction box (D-box) and KEN-box are commonly found in APC/C substrates, many substrates apparently lack these motifs. A variety of alternative APC/C degrons have been reported, suggesting either that multiple modes of substrate recognition are possible or that our definitions of degron structure are incomplete. We used an in vivo yeast assay to compare the G1 degradation rate of 15 known substrates of the APC/C co-activator Cdh1 under normal conditions and conditions that impair binding of D-box, KEN-box, and the recently identified ABBA motif degrons to Cdh1. The D-box receptor was required for efficient proteolysis of all Cdh1 substrates, despite the absence of canonical D-boxes in many. In contrast, the KEN-box receptor was only required for normal proteolysis of a subset of substrates and the ABBA motif receptor for a single substrate in our system. Our results suggest that binding to the D-box receptor may be a shared requirement for recognition and processing of all Cdh1 substrates.

  2. 9 CFR 355.32 - Labeling required.

    Science.gov (United States)

    2010-01-01

    ... ORGANIZATION AND TERMINOLOGY; MANDATORY MEAT AND POULTRY PRODUCTS INSPECTION AND VOLUNTARY INSPECTION AND... quantity of product in the container. (c) The name and place of business of the manufacturer, packer,...

  3. 40 CFR 205.158 - Labeling requirements.

    Science.gov (United States)

    2010-07-01

    ..., and four spaces for the advertised engine displacement respectively. (7) All motorcycle manufacturers... HOD Honda HON Husqvarna HUS JAWA/CZ JAW Kawasaki KAW KTM KTM Laverda LAV Moto Benilli BEN Moto Guzzi...

  4. 47 CFR 15.19 - Labelling requirements.

    Science.gov (United States)

    2010-10-01

    ... manual or pamphlet supplied to the user. However, the unique identification (trade name and model number... operated and must not be readily detachable. (c) (d) Consumer electronics TV receiving devices,...

  5. Optimizing the performance of in silico ADMET general models according to local requirements: MARS approach. solubility estimations as case study.

    Science.gov (United States)

    Oyarzabal, Julen; Pastor, Joaquin; Howe, Trevor J

    2009-12-01

    The quality of in vitro data used to build in silico absorption, distribution, metabolism, and toxicity (ADMET) models is, in many cases, inconsistent. The paucity of data from single laboratory sources has led to the mixing of data sets with varying experimental conditions and to the coverage of restricted chemical space in models which are purported to be of general applicability. In order to overcome these shortcomings, a method, Metropolis/Monte Carlo adaptive ranking simulation (MARS) has been developed. This aims to estimate "optimal flexible threshold points" in order to achieve better correlation between any in silico ADMET model and any discrete qualitative experimental data. The MARS method covers three key factors: the predictive model, the experimental procedure for the assay, and the chemical series or scaffold. When large and general solubility data sets (>650 compounds) are analyzed against commercially available in silico models, using MARS, an improvement in kappa statistics up to 16.2% is obtained. When particular chemical series are addressed, improvements up to 46.0% are seen on kappa statistics. This coefficient then allows an investigation into the effectiveness of a classifier by assessing the improvement over chance. These improvements in ranking estimations allow more predictive decision-making for virtual libraries.

  6. 40 CFR 63.1192 - What recordkeeping requirements must I meet?

    Science.gov (United States)

    2010-07-01

    ... recordkeeping requirements: (a) Maintain files of all information required by § 63.10(b) of the general... microfilm, on a computer, on computer disks, on magnetic tape disks, or on microfiche. (e) Report the required information on paper or on a labeled computer disk using commonly available and...

  7. N-terminal chemical protein labeling using the naturally split GOS-TerL intein.

    Science.gov (United States)

    Bachmann, Anne-Lena; Mootz, Henning D

    2017-07-01

    Chemoselective and regioselective chemical protein labeling is of great importance, yet no current technique is sufficiently general and simple to perform. Protein trans-splicing by split inteins can be used to ligate short tags with chemical labels to either the N or the C terminus of a protein. The CysTag approach exploits split intein fragments without a cysteine fused with such a short tag containing a single cysteine that is easily amenable to selective modification using classical cysteine bioconjugation. Labeling of the protein of interest is achieved through transfer of the pre-labeled tag by protein trans-splicing. This protocol keeps other cysteines unmodified. While split inteins for C-terminal CysTag labeling were previously reported, no high-yielding and naturally split intein for N-terminal labeling has been available. In this work, the recently discovered GOS-TerL intein was explored as the only known naturally split intein that both lacks a cysteine in its N-terminal fragment and is active under ambient conditions. Thioredoxin as a model protein and a camelid nanobody were labeled with a synthetic fluorophore by transferring the pre-labeling CysTag in the protein trans-splicing reaction with yields of about 50 to 90%. The short N-terminal intein fragment was also chemically synthesized with a tag to enable protein labeling by semi-synthetic protein trans-splicing. Our results expand the scope of the CysTag labeling strategy, which achieves selective chemical modification without the requirement for sophisticated biorthogonal functional groups and rather builds on the plethora of commercially available reagents directed at the thiol side chain of cysteine. Copyright © 2017 European Peptide Society and John Wiley & Sons, Ltd. Copyright © 2017 European Peptide Society and John Wiley & Sons, Ltd.

  8. Pesticide Product Label System

    Data.gov (United States)

    U.S. Environmental Protection Agency — The Pesticide Product Label System (PPLS) provides a collection of pesticide product labels (Adobe PDF format) that have been approved by EPA under Section 3 of the...

  9. Food Label and You

    Medline Plus

    Full Text Available ... has issued final changes to update the Nutrition Facts label for packaged foods. For more information, see Changes to the Nutrition Facts Label . FDA presents an entertaining and educational tool ...

  10. Semiotic labelled deductive systems

    Energy Technology Data Exchange (ETDEWEB)

    Nossum, R.T. [Imperial College of Science, Technology and Medicine, London (United Kingdom)

    1996-12-31

    We review the class of Semiotic Models put forward by Pospelov, as well as the Labelled Deductive Systems developed by Gabbay, and construct an embedding of Semiotic Models into Labelled Deductive Systems.

  11. Electronic Submission of Labels

    Science.gov (United States)

    Pesticide registrants can provide draft and final labels to EPA electronically for our review as part of the pesticide registration process. The electronic submission of labels by registrants is voluntary but strongly encouraged.

  12. Mental Labels and Tattoos

    Science.gov (United States)

    Hyatt, I. Ralph

    1977-01-01

    Discusses the ease with which mental labels become imprinted in our system, six basic axioms for maintaining negative mental tattoos, and psychological processes for eliminating mental tattoos and labels. (RK)

  13. Consumer trust in the Australian food system - The everyday erosive impact of food labelling.

    Science.gov (United States)

    Tonkin, Emma; Webb, Trevor; Coveney, John; Meyer, Samantha B; Wilson, Annabelle M

    2016-08-01

    Consumer trust in food system actors is foundational for ensuring consumer confidence in food safety. As food labelling is a direct communication between consumers and food system actors, it may influence consumer perceptions of actor trustworthiness. This study explores the judgements formed about the trustworthiness of the food system and its actors through labelling, and the expectations these judgements are based on. In-depth, semi-structured interviews with 24 Australian consumers were conducted. Theoretical sampling focussed on shopping location, dietary requirements, rurality, gender, age and educational background. The methodological approach used (adaptive theory) enabled emerging data to be examined through the lens of a set of guiding theoretical concepts, and theory reconsidered in light of emerging data. Food labelling acted as a surrogate for personal interaction with industry and government for participants. Judgements about the trustworthiness of these actors and the broader food system were formed through interaction with food labelling and were based on expectations of both competence and goodwill. Interaction with labelling primarily reduced trust in actors within the food system, undermining trust in the system as a whole. Labelling has a role as an access point to the food system. Access points are points of vulnerability for systems, where trust can be developed, reinforced or broken down. For the participants in this study, in general labelling demonstrates food system actors lack goodwill and violate their fiduciary responsibility. This paper provides crucial insights for industry and policy actors to use this access point to build, rather than undermine, trust in food systems.

  14. 21 CFR 101.10 - Nutrition labeling of restaurant foods.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Nutrition labeling of restaurant foods. 101.10 Section 101.10 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION FOOD LABELING General Provisions § 101.10 Nutrition labeling...

  15. 21 CFR 211.130 - Packaging and labeling operations.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Packaging and labeling operations. 211.130 Section... (CONTINUED) DRUGS: GENERAL CURRENT GOOD MANUFACTURING PRACTICE FOR FINISHED PHARMACEUTICALS Packaging and Labeling Control § 211.130 Packaging and labeling operations. There shall be written procedures designed...

  16. A Label to Regulate

    DEFF Research Database (Denmark)

    Tricoire, Aurélie; Boxenbaum, Eva; Laurent, Brice

    This paper examines the role labelling plays in the government of the contemporary economy.1Drawing on a detailed study of BBC-Effinergy, a French label for sustainable construction, we showhow the adoption and evolution of voluntary labels can be seen as emblematic of a governmentthrough experim...... experiment engaging 4 operations: stimulating market anticipations, focussing politicalconsultations, producing collective expertise and containing the regulatory transcription of the label....

  17. A General, Simple Catalyst for Enantiospecific Cross Couplings of Benzylic Ammonium Triflates and Boronic Acids: No Phosphine Ligand Required

    Science.gov (United States)

    Basch, Corey H.; Song, Ye-Geun; Watson, Mary P.

    2014-01-01

    Highly improved conditions for the enantiospecific cross coupling of benzylic ammonium triflates with boronic acids are reported. This method relies on the use of Ni(cod)2 without ancillary phosphine or N-heterocyclic carbene ligands as catalyst. These conditions enable the coupling of new classes of boronic acids and benzylic ammonium triflates. In particular, both heteroaromatic and vinyl boronic acids are well tolerated as coupling partners. In addition, these conditions enable the use of ammonium triflates with a variety of substituents at the benzylic stereocenter. Further, naphthyl-substitution is not required on the benzylic ammonium triflate; ammonium triflates with simple aromatic substituents also undergo this coupling. Good to high yields and levels of stereochemical fidelity are observed. This new catalyst system greatly expands the utility of enantiospecific cross couplings of these amine-derived substrates for the preparation of highly enantioenriched products. PMID:25364060

  18. Two New Standards Further Enhanced the Authenticity of Food Labels

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    @@ Recently, the General Administration of Quality Supervision, Inspection and Quarantine and the Standardization Administration of China approved and promulgated two compulsory national standards: the General Principles for the Labeling of Prepackaged Foods and the General Principles for the Labeling of Prepackaged Foods for Special Dietary Uses. These two standards will come into force from October 1, 2005.

  19. Frequency of genetic diseases and health coverage of children requiring admission in a general pediatric clinic of northern Greece

    Directory of Open Access Journals (Sweden)

    Lialiaris Theodoros

    2010-01-01

    Full Text Available Abstract Background In order to estimate the causes of pediatric morbidity in our area, with particular emphasis on diseases with a genetic background, we retrospectively categorized the admissions of all children hospitalized in the Department of Pediatrics of the University General Hospital of Alexandroupolis, in the area of Evros, Thrace, Greece over the three year period 2005-2007. Finally, in order to guide health care administrators to improve the delivery of pediatric health care services, we estimated the percentage of hospitalized children who were uninsured and the type of health insurance of those who had medical coverage. Patients and Methods The causes of admission, as recorded in the medical records were categorized in terms of the major organ and/or system involved and/or the underlying pathology, with emphasis on diseases with a genetic background. Duplicate admissions, i.e., admissions of the same child for the same underlying disease were excluded. Additional information recorded was age, sex, and type of health insurance of all admitted children. Distribution of the causes of admission by study year was compared by chi-square. A p value Results Over the study period, there were 4,947 admissions in 2,818 boys and 2,129 girls. Respiratory diseases were the most common accounting for 30%, while infectious diseases followed with 26.4%. The frequency of chromosomal abnormalities among the hospitalized children was only 0.06%. However, if we consider diseases with an underlying genetic background, this percentage rises to 5%. Approximately 10.3% of the admitted children had no health insurance. Conclusions The percentage of children hospitalized in our area due to a disease with an underlying genetic background was 5%. This percentage pertains to a Department of Pediatrics that has no inpatient subspecialty units and which is located within a General hospital, because hospitalizations for genetic diseases are more frequent in

  20. Improving standards and labels with IPMVP and Six Sigma strategies

    Energy Technology Data Exchange (ETDEWEB)

    Mowris, Robert; Jones, Ean [Robert Mowris and Associates (United States); Carlson, Kathleen [Verified, Inc. (United States)

    2007-07-01

    Efforts to improve energy efficiency and mitigate global warming through equipment and appliance standards and labels have been somewhat hampered by differences in energy consumption between actual and labeled energy use. In some cases actual energy use is 50 to 200 % greater than labeled energy use. The International Performance Measurement and Verification Protocol (IPMVP) can be used to evaluate standards and labels to improve performance. The California Public Utilities Commission, NYSERDA, the World Bank, and many state and federal agencies require adherence to IPMVP. The World Resources Inst. is recommending evaluation standards such as IPMVP for the Kyoto Protocol. Greenhouse gas trading policy encourages rigorous EM and V by applying savings discount factors tied to IPMVP Options. Efforts to increase customer satisfaction, resource efficiency, and improve profitability have motivated businesses worldwide to adopt Six Sigma strategies. Motorola, General Electric, Sony, Honda, Toyota, and many other companies have adopted Six Sigma to decrease costs and increase profitability and market share. Companies implementing Six Sigma find that 70 to 80 percent of the total cost of a product or service is determined in the design stage. The higher the quality of energy efficiency designed into a product, the lower its lifecycle costs. IPMVP and Six Sigma share similar objectives with respect to reducing lifecycle costs and improving performance through measurement and verification of quality and efficiency improvements. IPMVP provides a framework to measure and verify energy efficiency performance. Six Sigma strategies provide a framework to measure and verify energy savings and performance metrics at critical steps in the market chain (i.e., design, manufacturing, installation, and service). Incorporating IPMVP and Six Sigma into appliance standards and labels will improve reliability and ensure that labeled energy use is closer to actual energy use.

  1. Reduction-mediated technetium-99m labeling of monoclonal antibodies

    Energy Technology Data Exchange (ETDEWEB)

    Mather, S.J.; Ellison, D. (St. Bartholomews Hospital, London (England))

    1990-05-01

    A simple and generally applicable method for labeling antibodies with technetium-99m ({sup 99m}Tc) is described. Following reduction of intrinsic disulphide bonds, the antibody is labeled with {sup 99m}Tc in the presence of a weak competing ligand methylene diphosphonate. High labeling efficiencies (greater than 97%), in a final labeling step taking only a few minutes, can be routinely obtained with high in-vitro stability over 24 hr. No effect upon antibody reactivity is seen.

  2. Link Label Prediction in Signed Citation Network

    KAUST Repository

    Akujuobi, Uchenna

    2016-04-12

    Link label prediction is the problem of predicting the missing labels or signs of all the unlabeled edges in a network. For signed networks, these labels can either be positive or negative. In recent years, different algorithms have been proposed such as using regression, trust propagation and matrix factorization. These approaches have tried to solve the problem of link label prediction by using ideas from social theories, where most of them predict a single missing label given that labels of other edges are known. However, in most real-world social graphs, the number of labeled edges is usually less than that of unlabeled edges. Therefore, predicting a single edge label at a time would require multiple runs and is more computationally demanding. In this thesis, we look at link label prediction problem on a signed citation network with missing edge labels. Our citation network consists of papers from three major machine learning and data mining conferences together with their references, and edges showing the relationship between them. An edge in our network is labeled either positive (dataset relevant) if the reference is based on the dataset used in the paper or negative otherwise. We present three approaches to predict the missing labels. The first approach converts the label prediction problem into a standard classification problem. We then, generate a set of features for each edge and then adopt Support Vector Machines in solving the classification problem. For the second approach, we formalize the graph such that the edges are represented as nodes with links showing similarities between them. We then adopt a label propagation method to propagate the labels on known nodes to those with unknown labels. In the third approach, we adopt a PageRank approach where we rank the nodes according to the number of incoming positive and negative edges, after which we set a threshold. Based on the ranks, we can infer an edge would be positive if it goes a node above the

  3. 33 CFR 183.514 - Fuel tanks: Labels.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Fuel tanks: Labels. 183.514...) BOATING SAFETY BOATS AND ASSOCIATED EQUIPMENT Fuel Systems Equipment Standards § 183.514 Fuel tanks: Labels. (a) Each fuel tank must have a label that meets the requirements of paragraphs (b) through (d)...

  4. 78 FR 34565 - Modification of Mandatory Label Information for Wine

    Science.gov (United States)

    2013-06-10

    ... Information for Wine AGENCY: Alcohol and Tobacco Tax and Trade Bureau, Treasury. ACTION: Final rule; Treasury... the mandatory labeling requirements for wine. The regulatory change permits alcohol content to appear... regulatory change provides greater flexibility in wine labeling, and will conform the TTB wine labeling...

  5. 46 CFR 195.11-20 - Marking and label plate.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Marking and label plate. 195.11-20 Section 195.11-20... plate. (a) All vans shall be provided with a label plate stating light weight, gross weight, and power requirements where applicable. (b) For vans subject to inspection label plates shall provide space for the date...

  6. 19 CFR 122.115 - Labeling of cargo.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Labeling of cargo. 122.115 Section 122.115 Customs... AIR COMMERCE REGULATIONS Transit Air Cargo Manifest (TACM) Procedures § 122.115 Labeling of cargo. A warning label, as required by § 18.4(e) of this chapter, shall be attached to all transit air cargo...

  7. Connected Component Labeling Using Components Neighbors-Scan Labeling Approach

    Directory of Open Access Journals (Sweden)

    Akmal Rakhmadi

    2010-01-01

    Full Text Available Problem statement: Many approaches have been proposed in previous such as the classic sequential connected components labeling algorithm which is relies on two subsequent raster-scans of a binary image. This method produced good performance in terms of accuracy, but because of the implementation of the image processing systems now requires faster process of the computer, the speed of this technique’s process has become an important issue. Approach: A computational approach, called components neighbors-scan labeling algorithm for connected component labeling was presented in this study. This algorithm required scanning through an image only once to label connected components. The algorithm started by scanning from the head of the component’s group, before tracing all the components neighbors by using the main component’s information. This algorithm had desirable characteristics, it is simple while promoted accuracy and low time consuming. By using a table of components, this approach also gave other advantages as the information for the next higher process. Results: The approach had been tested with a collection of binary images. In practically all cases, the technique had successfully given the desired result. Averagely, from the results the algorithm increased the speed around 67.4% from the two times scanning method. Conclusion: Conclusion from the comparison with the previous method, the approach of components neighbors-scan for connected component labeling promoted speed, accuracy and simplicity. The results showed that the approach has a good performance in terms of accuracy, the time consumed and the simplicity of the algorithm.

  8. 78 FR 47154 - Food Labeling; Gluten-Free Labeling of Foods

    Science.gov (United States)

    2013-08-05

    ... beers subject to FDA's labeling requirements not brewed from gluten-containing grains may contain gluten... ``gluten-free'' labeling for FDA- regulated beers that currently make a ``gluten-free'' claim and that are... beer has been subject to processing that the manufacturer has determined will remove gluten below a 20...

  9. Succesful labelling schemes

    DEFF Research Database (Denmark)

    Juhl, Hans Jørn; Stacey, Julia

    2001-01-01

    It is usual practice to evaluate the success of a labelling scheme by looking at the awareness percentage, but in many cases this is not sufficient. The awareness percentage gives no indication of which of the consumer segments that are aware of and use labelling schemes and which do not. In the ......It is usual practice to evaluate the success of a labelling scheme by looking at the awareness percentage, but in many cases this is not sufficient. The awareness percentage gives no indication of which of the consumer segments that are aware of and use labelling schemes and which do not....... In the spring of 2001 MAPP carried out an extensive consumer study with special emphasis on the Nordic environmentally friendly label 'the swan'. The purpose was to find out how much consumers actually know and use various labelling schemes. 869 households were contacted and asked to fill in a questionnaire...... it into consideration when I go shopping. The respondent was asked to pick the most suitable answer, which described her use of each label. 29% - also called 'the labelling blind' - responded that they basically only knew the recycling label and the Government controlled organic label 'Ø-mærket'. Another segment of 6...

  10. Chain store management through private labels strategy

    Directory of Open Access Journals (Sweden)

    Martina Sopta

    2007-07-01

    Full Text Available The purpose of this paper is to examine the market shares of private labels in the European Union and on the global market, and to compare the results of the analysis with the level of presence of private labels on the Croatian market. Moreover, through the application of macro and microeconomic tools, the author tried to estimate the future trends of private labels in Croatia.For the purpose of the paper secondary and primary data was used in the research. Relevant scientific and professional literature of local and foreign authors was analyzed. In addition, a few recent research studies were analyzed and their results compared. Field research has been conducted by the survey method, with 225 respondents included in the intentional sample.The main hypothesis of the paper based on research is that, in total sales, private labels are gaining a growing share in all markets, regardless of the development level of those markets. Alongside the main hypothesis of the work, three supporting hypotheses were tested to see which private labels are a good alternative to other brands on the world market. Private labels are generally developed on generic products. The third supporting hypothesis starts from the assumption that the investments in the promotion of private labels are negligible, resulting in lower prices of thoseproducts. The results of research and analyses in the work indicate that the position of private labels will strengthen internationally, as part of the process of liberalization and globalization of trade flows. In the process of purchase of private labels the positioning of the point of sale and price have an increasing contribution. With the concentration of commerce in chain stores, the share of private labels grows, approaching a half of the total sales in some countries. Considering the Croatian market, according to the international product life cycle theory, the share of private labels in the total sales will grow in the future

  11. Efficient Thread Labeling for Monitoring Programs with Nested Parallelism

    Science.gov (United States)

    Ha, Ok-Kyoon; Kim, Sun-Sook; Jun, Yong-Kee

    It is difficult and cumbersome to detect data races occurred in an execution of parallel programs. Any on-the-fly race detection techniques using Lamport's happened-before relation needs a thread labeling scheme for generating unique identifiers which maintain logical concurrency information for the parallel threads. NR labeling is an efficient thread labeling scheme for the fork-join program model with nested parallelism, because its efficiency depends only on the nesting depth for every fork and join operation. This paper presents an improved NR labeling, called e-NR labeling, in which every thread generates its label by inheriting the pointer to its ancestor list from the parent threads or by updating the pointer in a constant amount of time and space. This labeling is more efficient than the NR labeling, because its efficiency does not depend on the nesting depth for every fork and join operation. Some experiments were performed with OpenMP programs having nesting depths of three or four and maximum parallelisms varying from 10,000 to 1,000,000. The results show that e-NR is 5 times faster than NR labeling and 4.3 times faster than OS labeling in the average time for creating and maintaining the thread labels. In average space required for labeling, it is 3.5 times smaller than NR labeling and 3 times smaller than OS labeling.

  12. Valuing labelling attributes with hedonic price analysis:

    DEFF Research Database (Denmark)

    Steiner, Bodo

    2004-01-01

    The market share of New World wines sold in many European countries has increased dramatically over the past decade. More aggressive marketing, together with a more distinct and recognizable labeling scheme, are often regarded as the keys to the marketing success of these new wines. This article...... that consumers consider regions jointly with grape varieties as proxies for brands. This contrasts with the general observation that grape varietal labeling is the distinctive feature of New World wines. Marketing implications are examined by considering the revenue impact of changes in labeling at the retail...

  13. Off-label prescriptions in Internal Medicine: difficulties involved

    Directory of Open Access Journals (Sweden)

    S. Gambetti

    2013-05-01

    Full Text Available INTRODUCTION Concern about off-label prescriptions, that is to say prescriptions of a drug for therapeutic indications and utilisations not approved in the medicine data sheet, is growing up more and more among hospital clinicians. AIM OF THE STUDY The aim of this work is to increase the consciousness that falling back upon off-label prescriptions has to be applied just in case of a validated therapeutic option missing, and provided that there are clinical evidences supporting the benefits reached by the patient through the assumption of that drug. Furthermore, it requires the patient involvement, in fact he has to be correctly informed and has to declare his acceptance to be treated with that kind of drug. The off-label prescription responsibility belongs to the prescribing clinician. The costs of these prescriptions can not be ascribed to the SSN (Servizio Sanitario Nazionale, unless the subjects treated are in-patients in the hospital or in a day-hospital service. METHODS a Understanding where the therapeutic indications arise and how to use medicines, on the basis of what is reported in the Summary of Product Characteristics (SPC following the correspondent declaration for marketing authorization. b Showing some examples of off-label utilisation. c Evaluating the current legislation that regulates and supports the possibility or impossibility to prescribe off-label. CONCLUSIONS It is always better to use offlabel drugs that are authorized: by Agenzia Italiana del Farmaco (AIFA, through the dynamic list of medicines included in the 648/96, by the Local Therapeutic Commission or by the Ethical Committee. The act of prescribing off-label drugs for out-patients has to be shared even with the patient’s general practitioner, who is responsible for the same patient territorially, knows his medical history very well and the potential chronic therapy assumed. This is important for a proper evaluation of possible interactions and incompatibilities

  14. Detection threshold of single SPIO-labeled cells with FIESTA.

    Science.gov (United States)

    Heyn, Chris; Bowen, Chris V; Rutt, Brian K; Foster, Paula J

    2005-02-01

    MRI of superparamagnetic iron oxide (SPIO)-labeled cells has become a valuable tool for studying the in vivo trafficking of transplanted cells. Cellular detection with MRI is generally considered to be orders of magnitude less sensitive than other techniques, such as positron emission tomography (PET), single photon emission-computed tomography (SPECT), or optical fluorescence microscopy. However, an analytic description of the detection threshold for single SPIO-labeled cells and the parameters that govern detection has not been adequately provided. In the present work, the detection threshold for single SPIO-labeled cells and the effect of resolution and SNR were studied for a balanced steady-state free precession (SSFP) sequence (3D-FIESTA). Based on the results from both theoretical and experimental analyses, an expression that predicts the minimum detectable mass of SPIO (m(c)) required to detect a single cell against a uniform signal background was derived: m(c) = 5v/(K(fsl) x SNR), where v is the voxel volume, SNR is the image signal-to-noise ratio, and K(fsl) is an empirical constant measured to be 6.2 +/- 0.5 x 10(-5) microl/pgFe. Using this expression, it was shown that the sensitivity of MRI is not very different from that of PET, requiring femtomole quantities of SPIO iron for detection under typical micro-imaging conditions (100 microm isotropic resolution, SNR = 60). The results of this work will aid in the design of cellular imaging experiments by defining the lower limit of SPIO labeling required for single cell detection at any given resolution and SNR.

  15. COMPARISON OF THE STUDY ABOUT HUMAN PROTEIN REQUIREMENT THROUGH TWO STABLE ISOTOPE LABELLED AMINO ACIDS%两种稳定同位素标记氨基酸测量人体蛋白质需要量的比较

    Institute of Scientific and Technical Information of China (English)

    田颖; 朴建华; 张宇辉; 刘健敏; 田园; 杨晓光

    2011-01-01

    Objective To compare the study of human protein requirement using oral route with two stable isotope labelled amino acids 1-13C-leucine and α -15N-lysine at the same time. Method Twenty healthy Chinese young women participated in the experiment. There were six dietary protein levels and three consecutive periods. In each period, subjects consumed the experimental diets on D1 to D6, and were given 13C-leucine and 15N-lysine oral dose on D7 for 4h to trace the metabolism of the amino acids in body. Blood, breath and urine samples were collected and enrichments of 13C and 15N in samples were detected. Oxidation rates of 13C and 15N were calculated and breakpoint analysis using a two-phase linear crossover model was used to calculate protein requirement. Results The protein requirement was 0.92 g/kg/d from the oxidation of 13C-leucine, but could not be obtained from the oxidation rate of 15N-lysine. Conclusion As an indicator amino acid, the protein requirement was 0.92 g/kg/d from 13C-Leu study, but lysine couldn't respond to the changes of protein intake levels. [ACTA NUTRIMENTA SINICA, 2011, 33(1): 5-9]%目的 探讨同时口服给予两种示踪剂1-13C-亮氨酸和α-15N-赖氨酸测量人体蛋白质需要量,结果是否一致.方法 选取20名健康青年女性作为研究对象,预设6个膳食蛋白质水平,3个连续的实验周期,在每个实验周期给予日常膳食6d,在D7持续口服13C-亮氨酸和15N-赖氨酸4h,收集给予同位素过程中的静脉血、呼出气和尿液样本.测定血浆、呼出气和尿液中的13C、15N的丰度,计算13C-亮氨酸和15N-赖氨酸的氧化率,建立二项回归曲线计算蛋白质的需要量.结果通过13C-亮氨酸计算的蛋白质需要量是0.92 g/kg/d,无法通过15N-赖氨酸的氧化率建立二项回归曲线求得蛋白质需要量.结论 口服途径以15N-赖氨酸作为示踪剂,不能较好的反映蛋白质摄入量的变化情况.

  16. [Modeling the requirements on routine data of general practitioners from the health-care researcher's point of view with the help of unified modeling langauge (UML)].

    Science.gov (United States)

    Kersting, M; Hauswaldt, J; Lingner, H

    2012-08-01

    Health-care research is, besides primary acquired study data, based on data from widely differing secondary sources. In order to link, compare and analyze data sources uniform models and methods are needed. This could be facilitated by a more structured description of requirements, models and methods of health-care research than those currently used. Suitable methods of presentation were sought in an approach to this target and the unified modeling language (UML) identified as a possible alternative. Using different tools 3 UML diagrams were created to represent some individual aspects of a scientific use file (SUF): A use case diagram as well as an activity and a class diagram. In the use case diagram we attempted to represent the general use cases of an SUF based on general practitioners routine data. Secondly a class diagram was constructed to visualize the contents and structure of a SUF. Thirdly an activity diagram was developed to graphically represent the concept of a general practitioner's episode of care. The creation of the UML diagrams was possible without any technical difficulties. Regarding the content the 3 diagrams must still be considered as prototypes. The use case diagram shows possible uses and users of an SUF, e. g. a research worker, industry but also the general practitioner who supplies the data. The class diagram reveals a general data structure that can serve information processes in practice and research. Besides aggregation, possibilities for specialization and generalization are essential elements of the class diagram that can be used meaningfully. The activity diagram for the schematic representation of a general practitioner's episode of care reveals the existence of multiple endpoints of an episode and the possibility to form relationships by means of episodes (diagnosis>therapy). The constructed diagrams are preliminary results and should be refined in future steps. Use case diagrams enable a rapid overview of the meaning and

  17. The effect of dexmedetomidine continuous infusion as an adjuvant to general anesthesia on sevoflurane requirements: A study based on entropy analysis

    Directory of Open Access Journals (Sweden)

    Chirag Ramanlal Patel

    2013-01-01

    Full Text Available Background: Dexmedetomidine, a α2 agonist as an adjuvant in general anesthesia, has anesthetic and analgesic-sparing property. Aims: To evaluate the effect of continuous infusion of dexmedetomidine alone, without use of opioids, on requirement of sevoflurane during general anesthesia with continuous monitoring of depth of anesthesia by entropy analysis. Materials and Methods: Sixty patients were randomly divided into 2 groups of 30 each. In group A, fentanyl 2 mcg/kg was given while in group B, dexmedetomidine was given intravenously as loading dose of 1 mcg/kg over 10 min prior to induction. After induction with thiopentone in group B, dexmedetomidine was given as infusion at a dose of 0.2-0.8 mcg/kg. Sevoflurane was used as inhalation agent in both groups. Hemodynamic variables, sevoflurane inspired fraction (FI sevo , sevoflurane expired fraction (ET sevo , and entropy (Response entropy and state entropy were continuously recorded. Statistical analysis was done by unpaired student′s t-test and Chi-square test for continuous and categorical variables, respectively. A P-value < 0.05 was considered significant. Results: The use of dexmedetomidine with sevoflurane was associated with a statistical significant decrease in ET sevo at 5 minutes post-intubation (1.49 ± 0.11 and 60 minutes post-intubation (1.11 ±0.28 as compared to the group A [1.73 ±0.30 (5 minutes; 1.68 ±0.50 (60 minutes]. There was an average 21.5% decrease in ET sevo in group B as compared to group A. Conclusions: Dexmedetomidine, as an adjuvant in general anesthesia, decreases requirement of sevoflurane for maintaining adequate depth of anesthesia.

  18. Consistency in the safety labeling of bioequivalent medications.

    Science.gov (United States)

    Duke, Jon; Friedlin, Jeff; Li, Xiaochun

    2013-03-01

    Bioequivalent medications are required by the Food and Drug Administration to have identical warnings on their labels. This requirement has both clinical and legal importance, yet has never been validated. We sought to determine the real-world consistency of electronic labeling for bioequivalent drugs from different manufacturers. Using natural language processing, we indexed the adverse drug reactions (ADRs) found in the Adverse Reactions and Post-Marketing sections of 9105 structured product labels. We calculated the standard deviation in ADR labeling for each bioequivalent drug and the percent deviation of each generic label from its corresponding brand. We also analyzed the performance of individual generic manufacturers. For the 25 drugs with the greatest discrepancy in labeled ADRs, we performed manual review to identify causes of inconsistency. 68% of multi-manufacturer drugs had discrepancies in ADR labeling. For a given drug, the mean deviation in number of labeled ADRs was 4.4, and the median was 0.8 (IQR 0 to 3.2). The mean range in number of labeled ADRs was 12 +/- 0.9, and the median was 2 (IQR 0 to 9). Overall, 77.9% of generic manufacturers produced labels differing from brand. Causes of inconsistency included missing tables, outdated post-marketing reports, and formatting issues. Despite FDA mandate, bioequivalent drugs often differ in their safety labeling. Physicians should be aware of such differences and regulators should consider new strategies for harmonizing bioequivalent labels. Copyright © 2012 John Wiley & Sons, Ltd.

  19. Internal labelling problem: an algorithmic procedure

    Energy Technology Data Exchange (ETDEWEB)

    Campoamor-Stursberg, Rutwig, E-mail: rutwig@mat.ucm.es [Departamento GeometrIa y TopologIa, Fac. CC. Matematicas, Universidad Complutense de Madrid, Plaza de Ciencias 3, E-28040 Madrid (Spain)

    2011-01-14

    Combining the decomposition of Casimir operators induced by the embedding of a subalgebra into a semisimple Lie algebra with the properties of commutators of subgroup scalars, an analytical algorithm for the computation of missing label operators with the commutativity requirement is proposed. Two new criteria for subgroups scalars to commute are given. The algorithm is completed with a recursive method to construct orthonormal bases of states. As examples to illustrate the procedure, four labelling problems are explicitly studied.

  20. Synthesis Of Labeled Metabolites

    Science.gov (United States)

    Martinez, Rodolfo A.; Silks, III, Louis A.; Unkefer, Clifford J.; Atcher, Robert

    2004-03-23

    The present invention is directed to labeled compounds, for example, isotopically enriched mustard gas metabolites including: [1,1',2,2'-.sup.13 C.sub.4 ]ethane, 1,1'-sulfonylbis[2-(methylthio); [1,1',2,2'-.sup.13 C.sub.4 ]ethane, 1-[[2-(methylsulfinyl)ethyl]sulfonyl]-2-(methylthio); [1,1',2,2'-.sup.13 C.sub.4 ]ethane, 1,1'-sulfonylbis[2-(methylsulfinyl)]; and, 2,2'-sulfinylbis([1,2-.sup.13 C.sub.2 ]ethanol of the general formula ##STR1## where Q.sup.1 is selected from the group consisting of sulfide (--S--), sulfone (--S(O)--), sulfoxide (--S(O.sub.2)--) and oxide (--O--), at least one C* is .sup.13 C, X is selected from the group consisting of hydrogen and deuterium, and Z is selected from the group consisting of hydroxide (--OH), and --Q.sup.2 --R where Q.sup.2 is selected from the group consisting of sulfide (--S--), sulfone(--S(O)--), sulfoxide (--S(O.sub.2)--) and oxide (--O--), and R is selected from the group consisting of hydrogen, a C.sub.1 to C.sub.4 lower alkyl, and amino acid moieties, with the proviso that when Z is a hydroxide and Q.sup.1 is a sulfide, then at least one X is deuterium.

  1. Food Label and You

    Medline Plus

    Full Text Available ... En Español Search FDA Submit search Popular Content Home Food Drugs Medical Devices Radiation-Emitting Products Vaccines, Blood & Biologics Animal & Veterinary Cosmetics Tobacco Products Food Home Food Ingredients, Packaging & Labeling Labeling & Nutrition The Food ...

  2. Association Between Flexible Duty Hour Policies and General Surgery Resident Examination Performance: A Flexibility in Duty Hour Requirements for Surgical Trainees (FIRST) Trial Analysis.

    Science.gov (United States)

    Blay, Eddie; Hewitt, D Brock; Chung, Jeanette W; Biester, Thomas; Fiore, James F; Dahlke, Allison R; Quinn, Christopher M; Lewis, Frank R; Bilimoria, Karl Y

    2017-02-01

    Concerns persist about the effect of current duty hour reforms on resident educational outcomes. We investigated whether a flexible, less-restrictive duty hour policy (Flexible Policy) was associated with differential general surgery examination performance compared with current ACGME duty hour policy (Standard Policy). We obtained examination scores on the American Board of Surgery In-Training Examination, Qualifying Examination (written boards), and Certifying Examination (oral boards) for residents in 117 general surgery residency programs that participated in the Flexibility in Duty Hour Requirements for Surgical Trainees (FIRST) Trial. Using bivariate analyses and regression models, we compared resident examination performance across study arms (Flexible Policy vs Standard Policy) for 2015 and 2016, and 1 year of the Qualifying Examination and Certifying Examination. Adjusted analyses accounted for program-level factors, including the stratification variable for randomization. In 2016, FIRST trial participants were 4,363 general surgery residents. Mean American Board of Surgery In-Training Examination scores for residents were not significantly different between study groups (Flexible Policy vs Standard Policy) overall (Flexible Policy: mean [SD] 502.6 [100.9] vs Standard Policy: 502.7 [98.6]; p = 0.98) or for any individual postgraduate year level. There was no difference in pass rates between study arms for either the Qualifying Examination (Flexible Policy: 90.4% vs Standard Policy: 90.5%; p = 0.99) or Certifying Examination (Flexible Policy: 86.3% vs Standard Policy: 88.6%; p = 0.24). Results from adjusted analyses were consistent with these findings. Flexible, less-restrictive duty hour policies were not associated with differences in general surgery resident performance on examinations during the FIRST Trial. However, more years under flexible duty hour policies might be needed to observe an effect. Copyright © 2016 American College of Surgeons

  3. Tissue Specific Labeling in Proteomics

    Directory of Open Access Journals (Sweden)

    Evelyn Ramberger

    2017-07-01

    Full Text Available Mass spectrometry-based proteomics is a powerful tool for identifying and quantifying proteins in biological samples. While it is routinely used for the characterization of simple cell line systems, the analysis of the cell specific proteome in multicellular organisms and tissues poses a significant challenge. Isolating a subset of cells from tissues requires mechanical and biochemical separation or sorting, a process which can alter cellular signaling, and thus, the composition of the proteome. Recently, several approaches for cell selective labeling of proteins, that include bioorthogonal amino acids, biotinylating enzymes, and genetic tools, have been developed. These tools facilitate the selective labeling of proteins, their interactome, or of specific cell types within a tissue or an organism, while avoiding the difficult and contamination-prone biochemical separation of cells from the tissue. In this review, we give an overview of existing techniques and their application in cell culture models and whole animals.

  4. 76 FR 13550 - Fur Products Labeling Act

    Science.gov (United States)

    2011-03-14

    ... misbranding and false advertising of fur products, and requires labeling of most fur products. 15 U.S.C. 69 et... advertising fur products. 16 CFR 301.38. Finally, to assist the Commission in enforcing these requirements... advertising of fur products, if any, are not covered by the Rules? (a) What evidence demonstrates the...

  5. Quantitative metabolism using AMS: Choosing a labeled precursor

    Energy Technology Data Exchange (ETDEWEB)

    Links, Jennifer [Center for Accelerator Mass Spectrometry L-397, Lawrence Livermore National Laboratory, 7000 East Avenue, Livermore, CA 94551 (United States); Palmblad, Magnus [Department of Parasitology, Leiden University, Leiden (Netherlands); Ognibene, Ted; Turteltaub, Ken [Center for Accelerator Mass Spectrometry L-397, Lawrence Livermore National Laboratory, 7000 East Avenue, Livermore, CA 94551 (United States); Bench, Graham, E-mail: bench1@llnl.go [Center for Accelerator Mass Spectrometry L-397, Lawrence Livermore National Laboratory, 7000 East Avenue, Livermore, CA 94551 (United States)

    2010-04-15

    Biological radioisotope studies suffer from a lack of sensitive measurement techniques and therefore traditionally require large amounts of labeled material to produce a measurable signal. Such quantities of materials are often significantly higher than naturally-occurring levels preventing these studies from replicating physiological conditions. AMS affords the sensitivity necessary to perform biological radioisotope studies with low levels of labeled material that preserve physiological conditions. The choice of labeled material can substantially affect the ease of interpretation and comprehensiveness of these studies. Here, the benefits and limitations of whole-cell labeling with {sup 14}C-glucose and targeted pathway labeling with {sup 14}C-nicotinic acid are discussed and compared.

  6. The dexmedetomidine concentration required after remifentanil anesthesia is three-fold higher than that after fentanyl anesthesia or that for general sedation in the ICU

    Directory of Open Access Journals (Sweden)

    Kunisawa T

    2014-10-01

    Full Text Available Takayuki Kunisawa,1 Kazuhiro Fujimoto,2 Atsushi Kurosawa,2 Michio Nagashima,2 Koji Matsui,2 Dai Hayashi,2 Kunihiko Yamamoto,2 Yuya Goto,2 Hiroaki Akutsu,3 Hiroshi Iwasaki21Surgical Operation Department, Asahikawa Medical University Hospital, 2Department of Anesthesiology and Critical Care Medicine, 3Central Laboratory for Research and Education, Asahikawa Medical University, Asahikawa, Hokkaido, JapanPurpose: The general dexmedetomidine (DEX concentration required for sedation of intensive care unit patients is considered to be approximately 0.7 ng/mL. However, higher DEX concentrations are considered to be required for sedation and/or pain management after major surgery using remifentanil. We determined the DEX concentration required after major surgery by using a target-controlled infusion (TCI system for DEX.Methods: Fourteen patients undergoing surgery for abdominal aortic aneurysms (AAA were randomly, double-blindly assigned to two groups and underwent fentanyl- or remifentanil-based anesthetic management. DEX TCI was started at the time of closing the peritoneum and continued for 12 hours after stopping propofol administration (M0; DEX TCI was adjusted according to the sedation score and complaints of pain. The doses and concentrations of all anesthetics and postoperative conditions were investigated.Results: Throughout the observation period, the predicted plasma concentration of DEX in the fentanyl group was stable at approximately 0.7 ng/mL. In contrast, the predicted plasma concentration of DEX in the remifentanil group rapidly increased and stabilized at approximately 2 ng/mL. The actual DEX concentration at 540 minutes after M0 showed a similar trend (0.54±0.14 [fentanyl] versus 1.57±0.39 ng/mL [remifentanil]. In the remifentanil group, the dopamine dose required and the duration of intubation decreased, and urine output increased; however, no other outcomes improved.Conclusion: The DEX concentration required after AAA surgery with

  7. Dgp71WD is required for the assembly of the acentrosomal Meiosis I spindle, and is not a general targeting factor for the γ-TuRC

    Directory of Open Access Journals (Sweden)

    Richard F. Reschen

    2012-03-01

    Dgp71WD/Nedd1 proteins are essential for mitotic spindle formation. In human cells, Nedd1 targets γ-tubulin to both centrosomes and spindles, but in other organisms the function of Dgp71WD/Nedd1 is less clear. In Drosophila cells, Dgp71WD plays a major part in targeting γ-tubulin to spindles, but not centrosomes, while in Xenopus egg extracts, Nedd1 acts as a more general microtubule (MT organiser that can function independently of γ-tubulin. The interpretation of these studies, however, is complicated by the fact that some residual Dgp71WD/Nedd1 is likely present in the cells/extracts analysed. Here we generate a Dgp71WD null mutant lacking all but the last 12 nucleotides of coding sequence. The complete loss of Dgp71WD has no quantifiable effect on γ-tubulin or Centrosomin recruitment to the centrosome in larval brain cells. The recruitment of γ-tubulin to spindle MTs, however, is severely impaired, and spindle MT density is reduced in a manner that is indistinguishable from cells lacking Augmin or γ-TuRC function. In contrast, the absence of Dgp71WD leads to defects in the assembly of the acentrosomal female Meiosis I spindle that are more severe than those seen in Augmin or γ-TuRC mutants, indicating that Dgp71WD has additional functions that are independent of these complexes in oocytes. Moreover, the localisation of bicoid RNA during oogenesis, which requires γ-TuRC function, is unperturbed in Dgp71WD120 mutants. Thus, Dgp71WD is not simply a general cofactor required for γ-TuRC and/or Augmin targeting, and it appears to have a crucial role independent of these complexes in the acentrosomal Meiosis I spindle.

  8. From Label to Practice

    DEFF Research Database (Denmark)

    Byrkjeflot, Haldor; Strandgaard, Jesper; Svejenova, Silviya

    2013-01-01

    This article examines the process of creation of new Nordic cuisine (NNC) as a culinary innovation, focusing on the main stages, actors, and mechanisms that shaped the new label and its practices and facilitated its diffusion in the region and internationally. Fast-paced diffusion was possible...... because NNC was conceived as an identity movement, triggered by active involvement of entrepreneurial leaders from the culinary profession, high-profile political supporters, legitimating scientists, disseminating media, and interpreting audiences. It was facilitated by three mechanisms: First, the use...... actors and institutions to develop practices associated with the NNC label. Third, organized dissemination allowed the excitement and engagement with the new label to spread quickly....

  9. Capacitive label reader

    Science.gov (United States)

    Arlowe, H. Duane

    1985-01-01

    A capacitive label reader includes an outer ring transmitting portion, an inner ring transmitting portion, and a plurality of insulated receiving portions. A label is the mirror-image of the reader except that identifying portions corresponding to the receiving portions are insulated from only one of two coupling elements. Positive and negative pulses applied, respectively, to the two transmitting rings biased a CMOS shift register positively to either a 1 or 0 condition. The output of the CMOS may be read as an indication of the label.

  10. Dynamic Visualization of Graphs with Extended Labels

    Energy Technology Data Exchange (ETDEWEB)

    Wong, Pak C.; Mackey, Patrick S.; Perrine, Kenneth A.; Eagan, James R.; Foote, Harlan P.; Thomas, Jim

    2005-10-23

    The paper describes a novel technique to visualize graphs with extended node and link labels. The lengths of these labels range from a short phrase to a full sentence to an entire paragraph and beyond. Our solution is different from all the existing approaches that almost always rely on intensive computational effort to optimize the label placement problem. Instead, we share the visualization resources with the graph and present the label information in static, interactive, and dynamic modes without the requirement for tackling the intractability issues. This allows us to reallocate the computational resources for dynamic presentation of real-time information. The paper includes a user study to evaluate the effectiveness and efficiency of the visualization technique.

  11. Infant sensitivity to speaker and language in learning a second label.

    Science.gov (United States)

    Bhagwat, Jui; Casasola, Marianella

    2014-02-01

    Two experiments examined when monolingual, English-learning 19-month-old infants learn a second object label. Two experimenters sat together. One labeled a novel object with one novel label, whereas the other labeled the same object with a different label in either the same or a different language. Infants were tested on their comprehension of each label immediately following its presentation. Infants mapped the first label at above chance levels, but they did so with the second label only when requested by the speaker who provided it (Experiment 1) or when the second experimenter labeled the object in a different language (Experiment 2). These results show that 19-month-olds learn second object labels but do not readily generalize them across speakers of the same language. The results highlight how speaker and language spoken guide infants' acceptance of second labels, supporting sociopragmatic views of word learning.

  12. Food Label and You

    Medline Plus

    Full Text Available ... Sports show highlighting the importance of using the nutrition facts label to control portions, fat, calories and percent daily value. Two studio "sports announcers" describe the "game day" food action of ...

  13. FDA Online Label Repository

    Data.gov (United States)

    U.S. Department of Health & Human Services — The drug labels and other drug-specific information on this Web site represent the most recent drug listing information companies have submitted to the Food and Drug...

  14. Figuring Out Food Labels

    Science.gov (United States)

    ... usually appears on the back or side of packaging under the title "Nutrition Facts." It's also displayed in grocery stores near fresh foods, like fruits, vegetables, and fish. The nutrition facts label includes: a column of ...

  15. Food Label and You

    Medline Plus

    Full Text Available ... use the Nutrition Facts Label to make informed food choices. You can view the new video in its ... two sites, comparing serving sizes, ingredients and overall food choices in this "Battle of the Dueling Dinner Parties". ...

  16. Behind the Label "Alcoholic."

    Science.gov (United States)

    Wright, Deborah M.

    1989-01-01

    Relates individual's personal story of her childhood influenced by her parent's alcoholism, her own alcoholism as a young adult, and her experiences with counseling. Asks others not to reject her because of the label "alcoholic." (ABL)

  17. Food Label and You

    Medline Plus

    Full Text Available ... main page content Skip to search Skip to topics menu Skip to common links HHS U.S. Department ... a contestant in food label knowledge. Questions cover topics such as Calories, Serving Size, Servings per Container, ...

  18. Factors associated with nutrition label use among female college students applying the theory of planned behavior

    Science.gov (United States)

    Lim, Hyun Jeong; Kim, Min Ju

    2015-01-01

    BACKGROUND/OBJECTIVES Use of nutrition labels in food selection is recommended for consumers. The aim of this study is to examine factors, mainly beliefs explaining nutrition label use in female college students based on the Theory of Planned Behavior (TPB). SUBJECTS/METHODS The subjects were female college students from a university in Seoul, Korea. The survey questionnaire was composed of items examining general characteristics, nutrition label use, behavioral beliefs, normative beliefs, corresponding motivation to comply, and control beliefs. The subjects (n = 300) responded to the questionnaire by self-report, and data from 275 students were analyzed using t-test or χ2-test. RESULTS The results showed that 37.8% of subjects were nutrition label users. Three out of 15 behavioral beliefs differed significantly by nutrition label use. Nutrition label users agreed more strongly on the benefits of using nutrition labels including 'comparing and selecting better foods' (P nutrition label use. Twelve out of 15 control beliefs differed significantly by nutrition label use. These included beliefs regarding constraints of using nutrition labels (e.g., time, spending money for healthy foods) and lack of nutrition knowledge (P nutrition labels in food selection was also significantly related to nutrition label use (P nutrition label use. To promote nutrition label use, nutrition education might focus on increasing perceived control over constraints of using nutrition labels, acquiring skills for checking nutrition labels, as well as the benefits of using nutrition labels and receiving support from significant others for nutrition label use. PMID:25671070

  19. GEO Label: User and Producer Perspectives on a Label for Geospatial Data

    Science.gov (United States)

    Lush, V.; Lumsden, J.; Masó, J.; Díaz, P.; McCallum, I.

    2012-04-01

    One of the aims of the Science and Technology Committee (STC) of the Group on Earth Observations (GEO) was to establish a GEO Label- a label to certify geospatial datasets and their quality. As proposed, the GEO Label will be used as a value indicator for geospatial data and datasets accessible through the Global Earth Observation System of Systems (GEOSS). It is suggested that the development of such a label will significantly improve user recognition of the quality of geospatial datasets and that its use will help promote trust in datasets that carry the established GEO Label. Furthermore, the GEO Label is seen as an incentive to data providers. At the moment GEOSS contains a large amount of data and is constantly growing. Taking this into account, a GEO Label could assist in searching by providing users with visual cues of dataset quality and possibly relevance; a GEO Label could effectively stand as a decision support mechanism for dataset selection. Currently our project - GeoViQua, - together with EGIDA and ID-03 is undertaking research to define and evaluate the concept of a GEO Label. The development and evaluation process will be carried out in three phases. In phase I we have conducted an online survey (GEO Label Questionnaire) to identify the initial user and producer views on a GEO Label or its potential role. In phase II we will conduct a further study presenting some GEO Label examples that will be based on Phase I. We will elicit feedback on these examples under controlled conditions. In phase III we will create physical prototypes which will be used in a human subject study. The most successful prototypes will then be put forward as potential GEO Label options. At the moment we are in phase I, where we developed an online questionnaire to collect the initial GEO Label requirements and to identify the role that a GEO Label should serve from the user and producer standpoint. The GEO Label Questionnaire consists of generic questions to identify whether

  20. Quality assurance, information tracking, and consumer labeling.

    Science.gov (United States)

    Caswell, Julie A

    2006-01-01

    Reducing marine-based public health risk requires strict control of several attributes of seafood products, often including location and conditions of catch or aquaculture, processing, and handling throughout the supply chain. Buyers likely will also be interested in other attributes of these products such as eco-friendliness or taste. Development of markets for improved safety, as well as for other quality attributes, requires an effective certification and tracking of these attributes as well as their communication to buyers. Several challenges must be met if labeling, particularly consumer labeling, is to support the development of markets for improved seafood safety.

  1. General Conformity

    Science.gov (United States)

    The General Conformity requirements ensure that the actions taken by federal agencies in nonattainment and maintenance areas do not interfere with a state’s plans to meet national standards for air quality.

  2. Labelling and Self-Esteem: The Impact of Using Specific vs. Generic Labels

    Science.gov (United States)

    Taylor, Laura Marie; Hume, Ian Robert; Welsh, Nikki

    2010-01-01

    The aim of this study is to investigate the relationship between being labelled either as having dyslexia or as having general special educational needs (SEN) and a child's self-esteem. Seventy-five children aged between 8 and 15 years categorised as having dyslexia (N = 26), as having general SEN (N = 26) or as having no learning difficulties (N…

  3. 群众路线教育实践活动总要求的内涵解读%Interpretation of the Connotation About the General Require-ments of Mass Line Campaign

    Institute of Scientific and Technical Information of China (English)

    孙柳

    2013-01-01

    党的群众路线教育实践活动明确提出“照镜子、正衣冠、洗洗澡、治治病”的总要求,概括起来就是要自我净化、自我完善、自我革新、自我提高。坚持把“照镜子、正衣冠、洗洗澡、治治病”总要求,贯穿落实到党的群众路线教育实践活动的全过程,就是要使广大党员干部尤其是领导干部,在宗旨意识、工作作风、廉洁自律上找出差距、修身正我;按照为民、务实、清廉的要求,自觉把党性修养正一正、把党员义务理一理、把党纪国法紧一紧,保持共产党人的良好形象;以整风精神开展批评与自我批评,清洗思想和行为上的灰尘,保持共产党人政治本色;坚持惩前毖后、治病救人方针,区别情况、对症下药,切实体现从严治党要求,确保教育实践活动沿着正确轨道健康深入推进。%The CPC’s mass line campaign clearly puts forward the general requirements, which include“taking a long look in the mirror, grooming oneself, taking a bath and seeking remedies”. In summary, it comes up with the demands of self purifica-tion, self-improvement, self-innovation and self-improvement. To implement the general requirements throughout the whole process of the campaign, we should urge party members and cadres, especially leading cadres, to find out the gap and cultivate their own morality in terms of the consciousness of principles, style of work, honesty and self-discipline. According to the re-quirements of“being people-oriented, practical and incorruptible”, we should consciously adjust the cultivation of party spirit, manage to fulfill the obligations of party members, and tighten the discipline of the Party and the law of our country so as to maintain a good image of the communists. Meanwhile, we should use the spirit of renovating the atmosphere to carry out the practice of criticism and self-criticism, clean the dust of our thoughts and

  4. Progressive multi-atlas label fusion by dictionary evolution.

    Science.gov (United States)

    Song, Yantao; Wu, Guorong; Bahrami, Khosro; Sun, Quansen; Shen, Dinggang

    2017-02-01

    Accurate segmentation of anatomical structures in medical images is important in recent imaging based studies. In the past years, multi-atlas patch-based label fusion methods have achieved a great success in medical image segmentation. In these methods, the appearance of each input image patch is first represented by an atlas patch dictionary (in the image domain), and then the latent label of the input image patch is predicted by applying the estimated representation coefficients to the corresponding anatomical labels of the atlas patches in the atlas label dictionary (in the label domain). However, due to the generally large gap between the patch appearance in the image domain and the patch structure in the label domain, the estimated (patch) representation coefficients from the image domain may not be optimal for the final label fusion, thus reducing the labeling accuracy. To address this issue, we propose a novel label fusion framework to seek for the suitable label fusion weights by progressively constructing a dynamic dictionary in a layer-by-layer manner, where the intermediate dictionaries act as a sequence of guidance to steer the transition of (patch) representation coefficients from the image domain to the label domain. Our proposed multi-layer label fusion framework is flexible enough to be applied to the existing labeling methods for improving their label fusion performance, i.e., by extending their single-layer static dictionary to the multi-layer dynamic dictionary. The experimental results show that our proposed progressive label fusion method achieves more accurate hippocampal segmentation results for the ADNI dataset, compared to the counterpart methods using only the single-layer static dictionary.

  5. Interaction with general transcription factor IIF (TFIIF) is required for the suppression of activated transcription by RPB5-mediating protein(RMP)

    Institute of Scientific and Technical Information of China (English)

    2003-01-01

    RMP was reported to regulate transcription via competing with HBx to bind the general transcription factor IIB (TFIIB) and interacting with RPB5 subunit of RNA polymerase Ⅱ as a corepressor of transcription regulator. However, our present research uncovered that RMP also regulates the transcription through interaction with the general transcription factors IIF (TFIIF), which assemble in the preinitiation complex and function in both transcription initiation and elongation. With in vitro pull-down assay and Far-Western analysis, we demonstrated that RMP could bind with bacterially expressed recombinant RAP30 and RAP74of TFIIF subunits. In the immunoprecipitation assay in COS 1 cells cotransfected with FLAG-tagged RMP or its mutants, GST-fused RAP30 and RAP74 were co-immunoprecipitated with RMP in approximately equal molar ratio, which suggests that RAP30 and RAP74 interact with RMP as a TFIIF complex. Interestingly both RAP30 and RAP74 interact with the same domain (D5) of the C-terminal RMP of 118-amino-acid residuals which overlaps with its TFIIB-binding domain. Internal deletion of D5 region of RMP abolished its binding ability with both subunits of TFIIF, while D5 domain alone was sufficient to interact with TFIIF subunits. The result of luciferase assay showed that overexpression of RMP, but not the mutant RMP lacking D5 region, suppressed the transcription activated by Gal-VP16, suggesting that interaction with TFIIF is required for RMP to suppress the activated transcription. The interaction between RMP and TFIIF may be an additional passway for RMP to regulate the transcription, or alternatively TFIIF may cooperate with RPB5 and TFIIB for the corepressor function of RMP.

  6. Gold Nanoparticle Labels Amplify Ellipsometric Signals

    Science.gov (United States)

    Venkatasubbarao, Srivatsa

    2008-01-01

    The ellipsometric method reported in the immediately preceding article was developed in conjunction with a method of using gold nanoparticles as labels on biomolecules that one seeks to detect. The purpose of the labeling is to exploit the optical properties of the gold nanoparticles in order to amplify the measurable ellipsometric effects and thereby to enable ultrasensitive detection of the labeled biomolecules without need to develop more-complex ellipsometric instrumentation. The colorimetric, polarization, light-scattering, and other optical properties of nanoparticles depend on their sizes and shapes. In the present method, these size-and-shape-dependent properties are used to magnify the polarization of scattered light and the diattenuation and retardance of signals derived from ellipsometry. The size-and-shape-dependent optical properties of the nanoparticles make it possible to interrogate the nanoparticles by use of light of various wavelengths, as appropriate, to optimally detect particles of a specific type at high sensitivity. Hence, by incorporating gold nanoparticles bound to biomolecules as primary or secondary labels, the performance of ellipsometry as a means of detecting the biomolecules can be improved. The use of gold nanoparticles as labels in ellipsometry has been found to afford sensitivity that equals or exceeds the sensitivity achieved by use of fluorescence-based methods. Potential applications for ellipsometric detection of gold nanoparticle-labeled biomolecules include monitoring molecules of interest in biological samples, in-vitro diagnostics, process monitoring, general environmental monitoring, and detection of biohazards.

  7. Atomoxetine Open-Label Trial in ADHD

    Directory of Open Access Journals (Sweden)

    J Gordon Millichap

    2002-07-01

    Full Text Available Atomoxetine (originally named tomoxetine, a new therapy for attention deficit hyperactivity disorder (ADHD marketed by Eli Lilly, was compared to methylphenidate in a prospective, randomized, open-label study for 10 weeks duration, at the University of Nebraska Medical Center, Massachusetts General Hospital, Mount Sinai Medical Center, Carolinas Medical Center, and Lilly Research Laboratories.

  8. European consumers and nutrition labelling

    DEFF Research Database (Denmark)

    Wills, Josephine M.; Grunert, Klaus G.; Celemín, Laura Fernández

    2009-01-01

    Nutrition labelling of food in Europe is not compulsory, unless a nutrition or health claim is made for the product. The European Commission is proposing mandatory nutrition labelling, even front of pack labelling with nutrition information. Yet, how widespread is nutrition labelling in the EU...

  9. Distance labeling schemes for trees

    DEFF Research Database (Denmark)

    Alstrup, Stephen; Gørtz, Inge Li; Bistrup Halvorsen, Esben;

    2016-01-01

    We consider distance labeling schemes for trees: given a tree with n nodes, label the nodes with binary strings such that, given the labels of any two nodes, one can determine, by looking only at the labels, the distance in the tree between the two nodes. A lower bound by Gavoille et al. [Gavoill...

  10. European consumers and nutrition labelling

    DEFF Research Database (Denmark)

    Wills, Josephine M.; Grunert, Klaus G.; Celemín, Laura Fernández

    2009-01-01

    Nutrition labelling of food in Europe is not compulsory, unless a nutrition or health claim is made for the product. The European Commission is proposing mandatory nutrition labelling, even front of pack labelling with nutrition information. Yet, how widespread is nutrition labelling in the EU...

  11. Thaw-and-use target cells pre-labeled with calcein AM for antibody-dependent cell-mediated cytotoxicity assays.

    Science.gov (United States)

    Chung, Shan; Nguyen, Van; Lin, Yuwen Linda; Kamen, Lynn; Song, An

    2017-08-01

    In vitro antibody-dependent cell-mediated cytotoxicity (ADCC) assays are routinely performed to support the research and development of therapeutic antibodies. In ADCC assays, target cells bound by the antibodies are lysed by activated effector cells following interactions between the Fc region of the bound antibody and Fcγ receptors on effector cells. Target cell lysis is typically measured by quantification of released endogenous enzymes, e.g., lactate dehydrogenase, or measurement of released exogenous labels, e.g., (51)Cr, europium or calcein. ADCC assays based on the detection of exogenous labels released from lysed target cells generally show higher sensitivity and require shorter incubation times. However, target cells are usually labeled immediately prior to assay, which inadvertently introduces additional assay variations due to differences in target cell conditions and labeling/handling processes. In this report, we describe the use of thaw-and-use pre-labeled target cells for ADCC assays. Thaw-and-use target cells in our experiments were pre-labeled with the fluorescent dye calcein AM, cryopreserved in single-use aliquots and used directly in assays after thawing. Upon thaw, the pre-labeled cells displayed viability and label retention comparable to freshly labeled cells, responded to ADCC mediated by both peripheral blood mononuclear cells and engineered natural killer cells, performed stably for at least 3 years and provided favorable precision and accuracy to ADCC assays. Implementation of thaw-and-use pre-labeled target cells in ADCC assays can help to alleviate both cell culture and dye labeling derived variability, increase the flexibility of assay scheduling and improve assay consistency and robustness. Copyright © 2017 Elsevier B.V. All rights reserved.

  12. Effect of a single dose of lidocaine and ketamine on intraoperative opioids requirements in patients undergoing elective gynecological laparotomies under general anesthesia. A randomized, placebo controlled pilot study

    Directory of Open Access Journals (Sweden)

    Jusset Teresa García-Navia

    2016-01-01

    Full Text Available Background and goal of study: there is evidence that perioperative intravenous ketamine and lidocaine reduce postoperative pain, postoperative opioids consumption, shortens hospital stay and accelerates intestinal function recovery. However, it has not been studied the beneficial effects in the intraoperative period. The aim of this study was to evaluate the effect of a single dose of lidocaine and ketamine on intraoperative opioids requirements in patients undergoing elective gynecological laparotomies under general anesthesia. Materials and methods: we performed a single-centre, prospective, randomized, double-blinded, placebo-controlled study. We included 33 patients (11 in the ketamine group, 11 in the lidocaine group and 11 in the placebo group. Postoperative analgesia was accomplished by patient-controlled morphine. Patients were randomly assigned to receive either a 1.5 mg/kg of 2% lidocaine, 0.5 mg/kg of 5% ketamine or 0.9% saline bolus. The primary outcome was the opioids consumption during surgery. The secondary outcomes included: emergence time, pain scores, opioids consumption within 24 h after surgery and side effects. Results: decreased intraoperative opioids requirements were noted in the experimental groups (ketamine: 402.3 } 106.3 and lidocaine: 397.7 } 107.5, compared with saline: 561.4 } 97.1; p = 0.001. We found a positive correlation between intraoperative opioids consumption and emergence time (r = 0.864, p < 0.001. There was no significant difference between the groups in VAS pain scores at rest within the first 24 postoperative hours. Total morphine consumption within 24 h after surgery did not differ significantly among the groups (placebo: 27.54 } 11.75; ketamine: 30.95 } 7.88; lidocaine 34.77 } 10.25; p = 0.26. Postoperative nausea and vomiting were more common in placebo group (it was observed in 3 subjects in ketamine group, in 5 subjects in lidocaine group and in 9 subjects in placebo group; p = 0

  13. Probabilistic atlas based labeling of the cerebral vessel tree

    Science.gov (United States)

    Van de Giessen, Martijn; Janssen, Jasper P.; Brouwer, Patrick A.; Reiber, Johan H. C.; Lelieveldt, Boudewijn P. F.; Dijkstra, Jouke

    2015-03-01

    Preoperative imaging of the cerebral vessel tree is essential for planning therapy on intracranial stenoses and aneurysms. Usually, a magnetic resonance angiography (MRA) or computed tomography angiography (CTA) is acquired from which the cerebral vessel tree is segmented. Accurate analysis is helped by the labeling of the cerebral vessels, but labeling is non-trivial due to anatomical topological variability and missing branches due to acquisition issues. In recent literature, labeling the cerebral vasculature around the Circle of Willis has mainly been approached as a graph-based problem. The most successful method, however, requires the definition of all possible permutations of missing vessels, which limits application to subsets of the tree and ignores spatial information about the vessel locations. This research aims to perform labeling using probabilistic atlases that model spatial vessel and label likelihoods. A cerebral vessel tree is aligned to a probabilistic atlas and subsequently each vessel is labeled by computing the maximum label likelihood per segment from label-specific atlases. The proposed method was validated on 25 segmented cerebral vessel trees. Labeling accuracies were close to 100% for large vessels, but dropped to 50-60% for small vessels that were only present in less than 50% of the set. With this work we showed that using solely spatial information of the vessel labels, vessel segments from stable vessels (>50% presence) were reliably classified. This spatial information will form the basis for a future labeling strategy with a very loose topological model.

  14. Distance labeling schemes for trees

    DEFF Research Database (Denmark)

    Alstrup, Stephen; Gørtz, Inge Li; Bistrup Halvorsen, Esben

    2016-01-01

    We consider distance labeling schemes for trees: given a tree with n nodes, label the nodes with binary strings such that, given the labels of any two nodes, one can determine, by looking only at the labels, the distance in the tree between the two nodes. A lower bound by Gavoille et al. [Gavoille...... variants such as, for example, small distances in trees [Alstrup et al., SODA, 2003]. We improve the known upper and lower bounds of exact distance labeling by showing that 1/4 log2(n) bits are needed and that 1/2 log2(n) bits are sufficient. We also give (1 + ε)-stretch labeling schemes using Theta......(log(n)) bits for constant ε> 0. (1 + ε)-stretch labeling schemes with polylogarithmic label size have previously been established for doubling dimension graphs by Talwar [Talwar, STOC, 2004]. In addition, we present matching upper and lower bounds for distance labeling for caterpillars, showing that labels...

  15. On the Power of Labels in Transition Systems

    DEFF Research Database (Denmark)

    Srba, Jirí

    2001-01-01

    In this paper we discuss the role of labels in transition systems with regard to bisimilarity and model checking problems. We suggest a general reduction from labelled transition systems to unlabelled ones, preserving bisimilarity and satisfiability of μ-calculus formulas. We apply the reduction ...

  16. A simple and optimal ancestry labeling scheme for trees

    DEFF Research Database (Denmark)

    Dahlgaard, Søren; Knudsen, Mathias Bæk Tejs; Rotbart, Noy Galil

    2015-01-01

    of papers. The last, due to Fraigniaud and Korman [STOC 10’], presented an asymptotically optimal lg n+4 lg lg n+ O(1) labeling scheme using non-trivial tree-decomposition techniques. By providing a framework generalizing interval based labeling schemes, we obtain a simple, yet asymptotically optimal...

  17. White matter lesion segmentation using machine learning and weakly labeled MR images

    Science.gov (United States)

    Xie, Yuchen; Tao, Xiaodong

    2011-03-01

    We propose a fast, learning-based algorithm for segmenting white matter (WM) lesions for magnetic resonance (MR) brain images. The inputs to the algorithm are T1, T2, and FLAIR images. Unlike most of the previously reported learning-based algorithms, which treat expert labeled lesion map as ground truth in the training step, the proposed algorithm only requires the user to provide a few regions of interest (ROI's) containing lesions. An unsupervised clustering algorithm is applied to segment these ROI's into areas. Based on the assumption that lesion voxels have higher intensity on FLAIR image, areas corresponding to lesions are identified and their probability distributions in T1, T2, and FLAIR images are computed. The lesion segmentation in 3D is done by using the probability distributions to generate a confidence map of lesion and applying a graph based segmentation algorithm to label lesion voxels. The initial lesion label is used to further refine the probability distribution estimation for the final lesion segmentation. The advantages of the proposed algorithm are: 1. By using the weak labels, we reduced the dependency of the segmentation performance on the expert discrimination of lesion voxels in the training samples; 2. The training can be done using labels generated by users with only general knowledge of brain anatomy and image characteristics of WM lesion, instead of these carefully labeled by experienced radiologists; 3. The algorithm is fast enough to make interactive segmentation possible. We test the algorithm on nine ACCORD-MIND MRI datasets. Experimental results show that our algorithm agrees well with expert labels and outperforms a support vector machine based WM lesion segmentation algorithm.

  18. The Effectiveness of Intravenous Dexmedetomidine on Perioperative Hemodynamics, Analgesic Requirement, and Side Effects Profile in Patients Undergoing Laparoscopic Surgery Under General Anesthesia

    Science.gov (United States)

    Panchgar, Vinayak; Shetti, Akshaya N.; Sunitha, H. B.; Dhulkhed, Vithal K.; Nadkarni, A. V.

    2017-01-01

    Background: There is an upward surge in the use of laparoscopic surgeries due to various advantages when compared to open surgeries. Major advantages are, due to small incisions which are cosmetically acceptable and most of them are now daycare procedures. Problem of economic burden and hospital bed occupancy has been overcome with laparoscopic surgeries. All these advantages are not free from disadvantages, as hemodynamic changes such as hypertension; tachycardia and other surgical-related complications are commonly observed intraoperatively. Dexmedetomidine is one of the α2 agonist drugs which acts at both supraspinal and spinal level and modulate the transmission of nociceptive signals in the central nervous system. The basic effect of dexmedetomidine on the cardiovascular system is to decrease the heart rate and systemic vascular resistance with additional feature of opioid sparing effect. This drug has become an ideal adjuvant during general anesthesia, especially when stress is expected. Hence, the drug was studied in laparoscopic surgeries. Aims and Objectives: (a) To study the effect of dexmedetomidine on hemodynamic parameters during perioperative period in patients undergoing laparoscopic surgery. (b) To study the postoperative sedation score and analgesic requirement. (c) To study the side effect profile of dexmedetomidine. Settings and Design: Randomized double blind controlled trial. Subjects and Methods: After obtaining the Institutional Ethical Clearance, the study was conducted. Forty patients of American Society of Anesthesiologists Class I and II were enrolled in this randomized study. The patients were randomly divided into two groups; group normal saline (NS) and group dexmedetomidine. Patient received either NS or dexmedetomidine in group NS and group dexmedetomidine, respectively, depending upon the allocation. The infusion rate was adjusted according to; loading dose (1 μg/kg) over 10 min and maintenance dose (0.5 μg/kg/h) and

  19. Techniques for labeling of optical signals in bust switched networks

    DEFF Research Database (Denmark)

    Tafur Monroy, Idelfonso; Koonen, A. M. J.; Zhang, Jianfeng

    2003-01-01

    multiplexed (WDM) networks due to its single forwarding algorithm, thus yielding low latency, and it enables scaling to terabit rates. Moreover, LOBS is compatible with the general multiprotocol label switching (GMPLS) framework for a unified control plane. We present a review on techniques for labeling......We present a review of significant issues related to labeled optical burst switched (LOBS) networks and technologies enabling future optical internet networks. Labeled optical burst switching provides a quick and efficient forwarding mechanism of IP packets/bursts over wavelength division...

  20. Labeling of Patient Specimens

    Science.gov (United States)

    2011-01-26

    noted during the event that the actu.al number of near miss incidmts reported monthly was low due to laboratory personnel performing rounds each...specimens never leaves label and if moved it is labeled), All orders in system and all near misses and errors reported to patient safety Purchase/Install...Meeting 14 Aug 09, 1400 in lab break room thru out Develop TICK sheet to track near misses .JDI Ms. Clark Clinics will provide toPS 1st working day of

  1. Synthesis of carbon-14 labeled doxylamine succinate

    Energy Technology Data Exchange (ETDEWEB)

    Rao, P.N.; Damodaran, K.M.

    1986-05-01

    Doxylamine succinate, N,N-dimethyl-2-(1-phenyl-1-(2-pyridinyl)-ethoxy)ethanamine succinate is an antihistamine used primarily as a sedative. Carbon-14 labeled doxylamine succinate, required for toxicological studies, was synthesized in two steps starting from 2-benzoyl pyridine.

  2. 46 CFR 160.072-7 - Manufacturer certification and labeling.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 6 2010-10-01 2010-10-01 false Manufacturer certification and labeling. 160.072-7..., Orange Flag § 160.072-7 Manufacturer certification and labeling. (a) Each distress flag intended as a Day Visual Distress Signal required by 33 CFR Part 175 must be certified by the manufacturer as...

  3. 46 CFR 161.013-13 - Manufacturer certification and labeling.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 6 2010-10-01 2010-10-01 false Manufacturer certification and labeling. 161.013-13... § 161.013-13 Manufacturer certification and labeling. (a) Each electric light intended as a Night Visual Distress Signal required by 33 CFR part 175 must be certified by the manufacturer as complying with...

  4. Learning to Recognize Human Activities from Soft Labeled Data

    NARCIS (Netherlands)

    Hu, N.; Lou, Z.; Englebienne, G.; Kröse, B.; Fox, D.; Kavraki, L.E.; Kurniawati, H.

    2014-01-01

    An activity recognition system is a very important component for assistant robots, but training such a system usually requires a large and correctly labeled dataset. Most of the previous works only allow training data to have a single activity label per segment, which is overly restrictive because

  5. 40 CFR 86.1807-01 - Vehicle labeling.

    Science.gov (United States)

    2010-07-01

    ..., and Complete Otto-Cycle Heavy-Duty Vehicles § 86.1807-01 Vehicle labeling. (a) The manufacturer of any motor vehicle subject to the applicable emission standards of this subpart, shall, at the time of... under 40 CFR 85.1505 must comply with the labeling requirements contained in 40 CFR 85.1510; (ix)...

  6. 10 CFR 34.35 - Labeling, storage, and transportation.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Labeling, storage, and transportation. 34.35 Section 34.35 Energy NUCLEAR REGULATORY COMMISSION LICENSES FOR INDUSTRIAL RADIOGRAPHY AND RADIATION SAFETY REQUIREMENTS FOR INDUSTRIAL RADIOGRAPHIC OPERATIONS Equipment § 34.35 Labeling, storage, and transportation....

  7. Commutativity of missing label operators in terms of Berezin brackets

    Energy Technology Data Exchange (ETDEWEB)

    Boya, Luis J [Dpto. Fisica Teorica, Facultad de Ciencias, Universidad de Zaragoza, E-50009 Zaragoza (Spain); Campoamor-Stursberg, Rutwig [Dpto. GeometrIa y TopologIa, Fac. CC. Matematicas, Universidad Complutense de Madrid, Plaza de Ciencias, 3 E-28040 Madrid (Spain)], E-mail: luisjo@unizar.es, E-mail: rutwig@mat.ucm.es

    2009-06-12

    We obtain a criterion on the commutativity of polynomials in the enveloping algebra of a Lie algebra in terms of an involution condition with respect to the Berezin bracket. As an application, it is shown that the commutativity requirement of missing label operators for reduction chains in the missing label problem can be solved analytically.

  8. Guide to good practices for equipment and piping labeling

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-12-01

    This Guide to Good Practices is written to enhance understanding of, and provide direction for, Equipment and Piping Labeling, Chapter XVIII of Department of Energy (DOE) Order 5480.19, Conduct of Operations Requirements for DOE Facilities. The practices in this guide should be considered when planning or reviewing labeling programs. Contractors are advised to adopt procedures that meet the intent of DOE Order 5480.19. Equipment and Piping Labeling is an element of an effective Conduct of Operations program. The complexity and array of activities performed in DOE facilities dictate the necessity for a coordinated labeling program to promote safe and efficient operations.

  9. Labelled Execution Systems

    Science.gov (United States)

    2012-05-07

    This is most starkly evident in the classical example used to demonstrate that, in the case of infinitely branching systems, a transfinite number of... transfinite number of iterations to converge, what can be shown to fail by appropriately embedding the labelled transition systems of [46, prop. 10.5

  10. Waisda?: video labeling game

    NARCIS (Netherlands)

    Hildebrand, M.; Brinkerink, M.; Gligorov, R.; Steenbergen, M. van; Huijkman, J.; Oomen, J.

    2013-01-01

    The Waisda? video labeling game is a crowsourcing tool to collect user-generated metadata for video clips. It follows the paradigm of games-with-a-purpose, where two or more users play against each other by entering tags that describe the content of the video. Players score points by entering the sa

  11. Multi-label

    Directory of Open Access Journals (Sweden)

    Neda Abdelhamid

    2015-01-01

    Full Text Available Generating multi-label rules in associative classification (AC from single label data sets is considered a challenging task making the number of existing algorithms for this task rare. Current AC algorithms produce only the largest frequency class connected with a rule in the training data set and discard all other classes even though these classes have data representation with the rule’s body. In this paper, we deal with the above problem by proposing an AC algorithm called Enhanced Multi-label Classifiers based Associative Classification (eMCAC. This algorithm discovers rules associated with a set of classes from single label data that other current AC algorithms are unable to induce. Furthermore, eMCAC minimises the number of extracted rules using a classifier building method. The proposed algorithm has been tested on a real world application data set related to website phishing and the results reveal that eMCAC’s accuracy is highly competitive if contrasted with other known AC and classic classification algorithms in data mining. Lastly, the experimental results show that our algorithm is able to derive new rules from the phishing data sets that end-users can exploit in decision making.

  12. Food Label and You

    Medline Plus

    Full Text Available ... Label and You — Video Share Tweet Linkedin Pin it More sharing options Linkedin Pin it Email Print NOTE: FDA has issued final changes ... choices. You can view the new video in its entirety or select on any of the individual ...

  13. Electrochemical Label-Free Nucleotide Sensors.

    Science.gov (United States)

    Aoki, Hiroshi

    2015-12-01

    Numerous researchers have devoted a great deal of effort over the last few decades to the development of electrochemical oligonucleotide detection techniques, owing to their advantages of simple design, inherently small dimensions, and low power requirements. Their simplicity and rapidity of detection makes label-free oligonucleotide sensors of great potential use as first-aid screening tools in the analytical field of environmental measurements and healthcare management. This review article covers label-free oligonucleotide sensors, focusing specifically on topical electrochemical techniques, including intrinsic redox reaction of bases, conductive polymers, the use of electrochemical indicators, and highly ordered probe structures.

  14. Performance limitations of label-free sensors in molecular diagnosis using complex samples

    Science.gov (United States)

    Varma, Manoj

    2016-03-01

    Label-free biosensors promised a paradigm involving direct detection of biomarkers from complex samples such as serum without requiring multistep sample processing typical of labelled methods such as ELISA or immunofluorescence assays. Label-free sensors have witnessed decades of development with a veritable zoo of techniques available today exploiting a multitude of physical effects. It is appropriate now to critically assess whether label-free technologies have succeeded in delivering their promise with respect to diagnostic applications, particularly, ambitious goals such as early cancer detection using serum biomarkers, which require low limits of detection (LoD). Comparison of nearly 120 limits of detection (LoD) values reported by labelled and label-free sensing approaches over a wide range of detection techniques and target molecules in serum revealed that labeled techniques achieve 2-3 orders of magnitude better LoDs. Data from experiments where labelled and label-free assays were performed simultaneously using the same assay parameters also confirm that the LoD achieved by labelled techniques is 2 to 3 orders of magnitude better than that by label-free techniques. Furthermore, label-free techniques required significant signal amplification, for e.g. using nanoparticle conjugated secondary antibodies, to achieve LoDs comparable to labelled methods substantially deviating from the original "direct detection" paradigm. This finding has important implications on the practical limits of applying label-free detection methods for molecular diagnosis.

  15. MULTI-LABEL CLASSIFICATION OF PRODUCT REVIEWS USING STRUCTURED SVM

    Directory of Open Access Journals (Sweden)

    Jincy B. Chrystal

    2015-05-01

    Full Text Available Most of the text classification problems are associated with multiple class labels and hence automatic text classification is one of the most challenging and prominent research area. Text classification is the problem of categorizing text documents into different classes. In the multi-label classification scenario, each document is associated may have more than one label. The real challenge in the multi-label classification is the labelling of large number of text documents with a subset of class categories. The feature extraction and classification of such text documents require an efficient machine learning algorithm which performs automatic text classification. This paper describes the multi-label classification of product review documents using Structured Support Vector Machine.

  16. Health Labeling, and Consumption- Understanding Determinants To Health Label Use.

    OpenAIRE

    Hoyer, David; Dossing, Jens; Zhuravleva, Anna

    2013-01-01

    Consumer behavior was explored through the understanding, and use of health labeling. Government and business forces were discovered to influence the ability of consumers to use health labels for improved health and life expectancy, and reduce the negative health care costs of food related diseases. Our survey results were compared to other papers and experiments in the field of consumption and labeling. We discovered high usage of labels, especially nutrition information, and a desire for fr...

  17. Rapid biosynthesis of stable isotope-labeled peptides from a reconstituted in vitro translation system for targeted proteomics.

    Science.gov (United States)

    Xian, Feng; Li, Shuwei; Liu, Siqi

    2015-01-01

    Stable isotope-labeled peptides are routinely used as internal standards (a.k.a. reference peptides) for absolute quantitation of proteins in targeted proteomics. These peptides can either be synthesized chemically on solid supports or expressed biologically by concatenating multiple peptides together to a large protein. Neither method, however, has required versatility, convenience, and economy for making a large number of reference peptides. Here, we describe the biosynthesis of stable isotope-labeled peptides from a reconstituted Escherichia coli in vitro translation system. We provide a detailed protocol on how to express these peptides with high purity and how to determine their concentrations with easiness. Our strategy offers a general, fast, and scalable approach for the easy preparation of labeled reference peptides, which will have broad application in both basic research and translational medicine.

  18. Decode the Sodium Label Lingo

    Science.gov (United States)

    ... For Preschooler For Gradeschooler For Teen Decode the Sodium Label Lingo Published January 24, 2013 Print Email Reading food labels can help you slash sodium. Here's how to decipher them. "Sodium free" or " ...

  19. European energy labelling scheme for windows

    Energy Technology Data Exchange (ETDEWEB)

    Belling Skou, Mette (VELUX A/S (Denmark)); Kragh, Jesper (DTU Byg, Denmarks Tekniske Univ., Lyngby (Denmark))

    2009-07-01

    In their proposals for revision of the energy labelling directive the European Commission has suggested to include windows. The paper introduces a proposal for an European energy labelling scheme of windows for replacement of windows in the existing building stock taking into consideration the energy performance of windows in both the heating and cooling seasons. The labelling scheme evaluates a methodology where the energy performance in the heating period is established with focus on heat loss and utilization of passive solar energy, whereas the energy performance in the summer (cooling) season will focus on reduction of solar radiation into the building. The methodology is developed with focus on CEN and ISO standardization. With inspiration from the American Energy Star programme for windows, Europe is divided into climate zones where the methodology for each zone is developed on basis of a reference building and climate data. A proposal for labelling will be presented for both heating and cooling seasons in order to enable the user to choose the right product for a specific performance. Based on data from the building stock in the individual climate zones, an energy saving potential for replacement of old windows with new low energy windows will be presented. The possibility for using energy labelling of windows as reference and requirement in the building legislation as an alternative to U-values, will be presented with among others examples from legislation in UK and Denmark.

  20. 75 FR 28335 - Testing and Labeling Pertaining to Product Certification

    Science.gov (United States)

    2010-05-20

    ... Safety Commission 16 CFR Part 1107 Testing and Labeling Pertaining to Product Certification; Proposed... Product Certification AGENCY: Consumer Product Safety Commission. ACTION: Proposed rule. SUMMARY: The... product complies with certification requirements under a reasonable testing program for...

  1. Labelling GM-free Products

    DEFF Research Database (Denmark)

    Punt, Maarten; Venus, Thomas; Wesseler, Justus

    2016-01-01

    Food suppliers in the EU must comply with labelling regulations for genetically modified organisms (GMOs). However, excluded from mandatory labelling are food products derived from animals fed with GM feed (mainly GM soybean in the EU). Because of this labelling exemption, consumers are unable to...

  2. Food Labels Tell the Story!

    Science.gov (United States)

    ... My World From the Label to the Table! Food Labels Tell the Story! What is in food? Food provides your body with all of the ... your food choices. Nutrition Facts—the Labels on Food Products Beginning in 1994, the US government began ...

  3. Modeling the effects of labeling

    DEFF Research Database (Denmark)

    Juhl, Hans Jørn; Fjord, Thomas Ahle; Poulsen, Carsten Stig

    A new approach to evaluate the consequences of labeling is presented and applied to test the potential effect of a label on fresh fish. Labeling effects on quality perceptions and overall quality are studied. The empirical study is based on an experimental design and nearly 500 respondents...

  4. Scaffolding Visitors' Learning through Labels

    Science.gov (United States)

    Wang, Joyce; Yoon, Susan

    2013-01-01

    In museum literature, labels have been found to increase visitor learning and contribute to greater cognitive gains. In this study, we seek to understand how various labels support the visitors' learning experience, and specifically in regards to conceptual and cognitive learning. We investigated the increasing use of three types of labels (visual…

  5. Groupware requirements evolution patterns

    NARCIS (Netherlands)

    Pumareja, Dulce Trinidad

    2013-01-01

    Requirements evolution is a generally known problem in software development. Requirements are known to change all throughout a system's lifecycle. Nevertheless, requirements evolution is a poorly understood phenomenon. Most studies on requirements evolution focus on changes to written specifications

  6. Clinically relevant safety issues associated with St. John's wort product labels

    Directory of Open Access Journals (Sweden)

    Rutledge Jennifer C

    2008-07-01

    Full Text Available Abstract Background St. John's wort (SJW, used to treat depression, is popular in the USA, Canada, and parts of Europe. However, there are documented interactions between SJW and prescription medications including warfarin, cyclosporine, indinavir, and oral contraceptives. One source of information about these safety considerations is the product label. The aim of this study was to evaluate the clinically relevant safety information included on labeling in a nationally representative sample of SJW products from the USA. Methods Eight clinically relevant safety issues were identified: drug interactions (SJW-HIV medications, SJW-immunosupressants, SJW-oral contraceptives, and SJW-warfarin, contraindications (bipolar disorder, therapeutic duplication (antidepressants, and general considerations (phototoxicity and advice to consult a healthcare professional (HCP. A list of SJW products was identified to assess their labels. Percentages and totals were used to present findings. Results Of the seventy-four products evaluated, no product label provided information for all 8 evaluation criteria. Three products (4.1% provided information on 7 of the 8 criteria. Four products provided no safety information whatsoever. Percentage of products with label information was: SJW-HIV (8.1%, SJW-immunosupressants (5.4%, SJW-OCPs (8.1%, SJW-warfarin (5.4%, bipolar (1.4%, antidepressants (23.0%, phototoxicity (51.4%, and consult HCP (87.8%. Other safety-related information on labels included warnings about pregnancy (74.3%, lactation (64.9%, discontinue if adverse reaction (23.0%, and not for use in patients under 18 years old (13.5%. The average number of a priori safety issues included on a product label was 1.91 (range 0–8 for 23.9% completeness. Conclusion The vast majority of SJW products fail to adequately address clinically relevant safety issues on their labeling. A few products do provide an acceptable amount of information on clinically relevant safety

  7. Simulation of spin label structure and its implication in molecular characterization

    Science.gov (United States)

    Fajer, Piotr; Fajer, Mikolai; Zawrotny, Michael; Yang, Wei

    2016-01-01

    Interpretation of EPR from spin labels in terms of structure and dynamics requires knowledge of label behavior. General strategies were developed for simulation of labels used in EPR of proteins. The criteria for those simulations are: (a) exhaustive sampling of rotamer space; (b) consensus of results independent of starting points; (c) inclusion of entropy. These criteria are satisfied only when the number of transitions in any dihedral angle exceeds 100 and the simulation maintains thermodynamic equilibrium. Methods such as conventional MD do not efficiently cross energetic barriers, Simulated Annealing, Monte Carlo or popular Rotamer Library methodologies are potential energy based and ignore entropy (in addition to their specific shortcomings: environment fluctuations, fixed environment or electrostatics). Simulated Scaling method, avoids above flaws by modulating the forcefields between 0 (allowing crossing energy barriers) and full potential (sampling minima). Spin label diffuses on this surface while remaining in thermodynamic equilibrium. Simulations show that: (a) single conformation is rare, often there are 2–4 populated rotamers; (b) position of the NO varies up to 16Å. These results illustrate necessity for caution when interpreting EPR signals in terms of molecular structure. For example the 10–16Å distance change in DEER should not be interpreted as a large conformational change, it can well be a flip about Cα -Cβ bond. Rigorous exploration of possible rotamer structures of a spin label is paramount in signal interpretation. We advocate use of bifunctional labels, which motion is restricted 10,000-fold and the NO position is restricted to 2–5Å. PMID:26478501

  8. Correlates of Social Exclusion and Negative Labeling and Devaluation of People Living with HIV/AIDS in Rural Settings: Evidence from a General Household Survey in Zambézia Province, Mozambique

    Science.gov (United States)

    Mukolo, Abraham; Blevins, Meridith; Victor, Bart; Vaz, Lara M. E.; Sidat, Mohsin; Vergara, Alfredo

    2013-01-01

    Background Increased HIV/AIDS knowledge and access to antiretroviral treatment (ART) have been hypothesized to decrease HIV stigma. However, stigma persists as a barrier to HIV services uptake. We studied the relationship between stigma, knowledge and attitudes towards HIV and its treatment, and confidence in the legal system (legal rights certitude). Methods We analyzed data from a household survey of 3749 randomly sampled female heads of households in 259 enumeration areas across 14 districts of Zambézia Province, Mozambique. The questionnaire included questions about beliefs, attitudes and behavior towards PLWHA, HIV transmission knowledge, treatment-related beliefs, and legal rights certitude. Factor analysis distinguished two stigma constructs: Negative labeling and devaluation (NLD) and social exclusion (SoE). Multivariable linear regression was used to determine the association between stigma, knowledge of HIV/AIDS, treatment-related beliefs, and legal rights certitude, while controlling for variance in socio-demographics. Results A 4-point increase in knowledge about HIV transmission was associated with more than a 3 unit decrease in NLD and SoE stigma scores (p<0.001). Given HIV transmission knowledge, a 25-point increase in legal rights certitude was associated with a 4.62 unit drop in NLD stigma (p<0.001); we did not detect an association between legal rights certitude and SoE stigma. Knowing at least one HIV positive person was associated with lower SoE (−3.17, 95% CI: −5.78, −0.56); no association with NLD (p = 0.1) was detected. ART efficacy belief was associated with higher NLD and lower SoE (2.90 increase and 6.94 decrease, respectively; p≤0.001). Conclusion Increasing knowledge about HIV transmission and access to ART are likely to reduce stigma, but neither of the two is a panacea. Raising community awareness of the legal rights of PLWHA might improve the efficacy of stigma reduction efforts. Strategies that focus on specific domains

  9. The Effects of Symptom Recognition and Diagnostic Labels on Public Beliefs, Emotional Reactions, and Stigmas Associated with Intellectual Disability

    Science.gov (United States)

    Scior, Katrina; Connolly, Theresa; Williams, Janice

    2013-01-01

    Labels are firmly rejected by the disability rights movement, yet the complex effects of labeling on lay beliefs are poorly understood. This study examined the effects of labeling on the general public's reactions to people with intellectual disabilities. A sample of 1,233 adult members of the UK general population were randomly presented with…

  10. 49 CFR 172.404 - Labels for mixed and consolidated packaging.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false Labels for mixed and consolidated packaging. 172..., TRAINING REQUIREMENTS, AND SECURITY PLANS Labeling § 172.404 Labels for mixed and consolidated packaging. (a) Mixed packaging. When hazardous materials having different hazard classes are packed within...

  11. Linerless label device and method

    KAUST Repository

    Binladen, Abdulkari

    2016-01-14

    This apparatus and method for applying a linerless label to an end user product includes a device with a printer for printing on a face surface of a linerless label, and a release coat applicator for applying a release coat to the face surface of the label; another device including an unwinder unit (103) to unwind a roll of printed linerless label; a belt (108); a glue applicator (102) for applying glue to the belt; a nip roller (106) for contacting and applying pressure to the face surface of the linerless label such that the glue on the belt transfers to the back surface of the linerless label; at least one slitting knife 105) positioned downstream the belt and a rewinder unit (104) positioned downstream the slitting knife; and a third device which die cuts and applies the linerless label to an end user object.

  12. Labeled Antimicrobial Peptides for Detection of Microorganisms

    Science.gov (United States)

    2008-12-01

    Beer , C, Koka, R. and Wang, X., 2001: Solid-Phase Capture of Proteins, Spores, and Bacteria. Applied and Environmental Microbiology , 67: 1300-1307. Yu...detection but often lack stability and sensitivity. Current biosensor technologies using fluorescently labeled antibodies are generally capable of...biosensor. J. ofRapid Methods and Automation in Microbiology , 9: 241- 257. Demarco, D. R. and Lim, D. Y., 2002: Detection of Escherichia coli 0157:H7

  13. Cell-free measurements of brightness of fluorescently labeled antibodies

    Science.gov (United States)

    Zhou, Haiying; Tourkakis, George; Shi, Dennis; Kim, David M.; Zhang, Hairong; Du, Tommy; Eades, William C.; Berezin, Mikhail Y.

    2017-02-01

    Validation of imaging contrast agents, such as fluorescently labeled imaging antibodies, has been recognized as a critical challenge in clinical and preclinical studies. As the number of applications for imaging antibodies grows, these materials are increasingly being subjected to careful scrutiny. Antibody fluorescent brightness is one of the key parameters that is of critical importance. Direct measurements of the brightness with common spectroscopy methods are challenging, because the fluorescent properties of the imaging antibodies are highly sensitive to the methods of conjugation, degree of labeling, and contamination with free dyes. Traditional methods rely on cell-based assays that lack reproducibility and accuracy. In this manuscript, we present a novel and general approach for measuring the brightness using antibody-avid polystyrene beads and flow cytometry. As compared to a cell-based method, the described technique is rapid, quantitative, and highly reproducible. The proposed method requires less than ten microgram of sample and is applicable for optimizing synthetic conjugation procedures, testing commercial imaging antibodies, and performing high-throughput validation of conjugation procedures.

  14. Principles of food product labelling

    Directory of Open Access Journals (Sweden)

    Krystyna Krysztofiak

    2011-09-01

    Full Text Available The purpose of the label of the food product is to provide information on ingredients and additionally on its origin, production method, storage conditions, date tagging, as well as to enable to identify the producer or distributor of this product. Legal regulations precisely give instructions on the range and the way of the presentation of these data, so they could be clear and understandable for the average consumer. Since 25th of November 2005, the information about allergens’ presence must be placed on the label, regardless of their content in the product (Directive 2003/89/WE... 2003 – Off. J. L 308: 15-18. The Regulation (WE No 1924/2006 about placing the nutritional information and medicinal claims concerning foods (Regulation (WE No 1924/2006... 2006 a is valid in all countries of European Union since 1st of July 2007 (Off. J. L 404: 9-25. It coordinates the legislative, executive and administrative regulations connected with this labelling. According to these regulations, “nutritional information” states, suggests or gives to understand that the food product has special properties concerning its ingredients. Those statements are of type: “the source of...”, “no... content”, “high content of...”, “low content of...”, “reduced content of...” with reference to calorie or selected ingredients’ content. “Medicinal claims” state, suggest or give to understand, that there is a connection between the food product or one of its ingredients and the health condition of the consumer. First type of these medicinal claims refers to the influence of the ingredient on the physiology. Such a statement is based on generally accepted scientific conclusions and could be properly understood by the average consumer, e.g. “calcium takes part in the process of building of strong bones”. “Statements about decreasing the risk of a disease” give information, that food product or one of its ingredients efficiently

  15. Visualizing dengue virus through Alexa Fluor labeling.

    Science.gov (United States)

    Zhang, Summer; Tan, Hwee Cheng; Ooi, Eng Eong

    2011-07-09

    The early events in the interaction between virus and cell can have profound influence on the outcome of infection. Determining the factors that influence this interaction could lead to improved understanding of disease pathogenesis and thus influence vaccine or therapeutic design. Hence, the development of methods to probe this interaction would be useful. Recent advancements in fluorophores development and imaging technology can be exploited to improve our current knowledge on dengue pathogenesis and thus pave the way to reduce the millions of dengue infections occurring annually. The enveloped dengue virus has an external scaffold consisting of 90 envelope glycoprotein (E) dimers protecting the nucleocapsid shell, which contains a single positive strand RNA genome. The identical protein subunits on the virus surface can thus be labeled with an amine reactive dye and visualized through immunofluorescent microscopy. Here, we present a simple method of labeling of dengue virus with Alexa Fluor succinimidyl ester dye dissolved directly in a sodium bicarbonate buffer that yielded highly viable virus after labeling. There is no standardized procedure for the labeling of live virus and existing manufacturer's protocol for protein labeling usually requires the reconstitution of dye in dimethyl sulfoxide. The presence of dimethyl sulfoxide, even in minute quantities, can block productive infection of virus and also induce cell cytotoxicity. The exclusion of the use of dimethyl sulfoxide in this protocol thus reduced this possibility. Alexa Fluor dyes have superior photostability and are less pH-sensitive than the common dyes, such as fluorescein and rhodamine, making them ideal for studies on cellular uptake and endosomal transport of the virus. The conjugation of Alexa Fluor dye did not affect the recognition of labeled dengue virus by virus-specific antibody and its putative receptors in host cells. This method could have useful applications in virological studies.

  16. Quantitative localization microscopy: effects of photophysics and labeling stoichiometry.

    Directory of Open Access Journals (Sweden)

    Robert P J Nieuwenhuizen

    Full Text Available Quantification in localization microscopy with reversibly switchable fluorophores is severely hampered by the unknown number of switching cycles a fluorophore undergoes and the unknown stoichiometry of fluorophores on a marker such as an antibody. We overcome this problem by measuring the average number of localizations per fluorophore, or generally per fluorescently labeled site from the build-up of spatial image correlation during acquisition. To this end we employ a model for the interplay between the statistics of activation, bleaching, and labeling stoichiometry. We validated our method using single fluorophore labeled DNA oligomers and multiple-labeled neutravidin tetramers where we find a counting error of less than 17% without any calibration of transition rates. Furthermore, we demonstrated our quantification method on nanobody- and antibody-labeled biological specimens.

  17. A generative probability model of joint label fusion for multi-atlas based brain segmentation.

    Science.gov (United States)

    Wu, Guorong; Wang, Qian; Zhang, Daoqiang; Nie, Feiping; Huang, Heng; Shen, Dinggang

    2014-08-01

    Automated labeling of anatomical structures in medical images is very important in many neuroscience studies. Recently, patch-based labeling has been widely investigated to alleviate the possible mis-alignment when registering atlases to the target image. However, the weights used for label fusion from the registered atlases are generally computed independently and thus lack the capability of preventing the ambiguous atlas patches from contributing to the label fusion. More critically, these weights are often calculated based only on the simple patch similarity, thus not necessarily providing optimal solution for label fusion. To address these limitations, we propose a generative probability model to describe the procedure of label fusion in a multi-atlas scenario, for the goal of labeling each point in the target image by the best representative atlas patches that also have the largest labeling unanimity in labeling the underlying point correctly. Specifically, sparsity constraint is imposed upon label fusion weights, in order to select a small number of atlas patches that best represent the underlying target patch, thus reducing the risks of including the misleading atlas patches. The labeling unanimity among atlas patches is achieved by exploring their dependencies, where we model these dependencies as the joint probability of each pair of atlas patches in correctly predicting the labels, by analyzing the correlation of their morphological error patterns and also the labeling consensus among atlases. The patch dependencies will be further recursively updated based on the latest labeling results to correct the possible labeling errors, which falls to the Expectation Maximization (EM) framework. To demonstrate the labeling performance, we have comprehensively evaluated our patch-based labeling method on the whole brain parcellation and hippocampus segmentation. Promising labeling results have been achieved with comparison to the conventional patch-based labeling

  18. Requirements dilemma

    OpenAIRE

    2006-01-01

    This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University. Knowing ‘what’ to build is an integral part of an Information System Development, and it is generally understood that this, which is known as Requirements, is achievable through a process of understanding, communication and management. It is currently maintained by the Requirements theorists that successful system design clarifies the interrelations between information and its representations...

  19. From Label to Practice

    DEFF Research Database (Denmark)

    Byrkjeflot, Haldor; Strandgaard, Jesper; Svejenova, Silviya

    2013-01-01

    This article examines the process of creation of new Nordic cuisine (NNC) as a culinary innovation, focusing on the main stages, actors, and mechanisms that shaped the new label and its practices and facilitated its diffusion in the region and internationally. Fast-paced diffusion was possible...... because NNC was conceived as an identity movement, triggered by active involvement of entrepreneurial leaders from the culinary profession, high-profile political supporters, legitimating scientists, disseminating media, and interpreting audiences. It was facilitated by three mechanisms: First, the use...

  20. Specific carbon-13 labelling of leucine residues in human growth hormone

    Energy Technology Data Exchange (ETDEWEB)

    Christensen, T.; Jensen, E.B.; Junker, F.; Dalboege, H. (Novo Nordisk A/S, Bagsvaerd (Denmark)); Abildgaard, F.; Led, J.J. (Department of Chemistry, University of Copenhagen, The H.C. Oersted Institute (Denmark))

    1992-01-01

    Biosynthetic human growth hormone specifically {sup 13}C-labelled in the carbonyl positions of all 26 leucine residues has been obtained by recombiant DNA techniques using {sup 13}C-labelled leucine and an E. coli strain that requires leucine. It is shown that, on the whole, the labelling is specific with no significant mislabelling as would have been the case had the {sup 13}C-labelled leucine been metabolized. (au).

  1. Cielo Computational Environment Usage Model With Mappings to ACE Requirements for the General Availability User Environment Capabilities Release Version 1.1

    Energy Technology Data Exchange (ETDEWEB)

    Vigil,Benny Manuel [Los Alamos National Laboratory; Ballance, Robert [SNL; Haskell, Karen [SNL

    2012-08-09

    Cielo is a massively parallel supercomputer funded by the DOE/NNSA Advanced Simulation and Computing (ASC) program, and operated by the Alliance for Computing at Extreme Scale (ACES), a partnership between Los Alamos National Laboratory (LANL) and Sandia National Laboratories (SNL). The primary Cielo compute platform is physically located at Los Alamos National Laboratory. This Cielo Computational Environment Usage Model documents the capabilities and the environment to be provided for the Q1 FY12 Level 2 Cielo Capability Computing (CCC) Platform Production Readiness Milestone. This document describes specific capabilities, tools, and procedures to support both local and remote users. The model is focused on the needs of the ASC user working in the secure computing environments at Lawrence Livermore National Laboratory (LLNL), Los Alamos National Laboratory, or Sandia National Laboratories, but also addresses the needs of users working in the unclassified environment. The Cielo Computational Environment Usage Model maps the provided capabilities to the tri-Lab ASC Computing Environment (ACE) Version 8.0 requirements. The ACE requirements reflect the high performance computing requirements for the Production Readiness Milestone user environment capabilities of the ASC community. A description of ACE requirements met, and those requirements that are not met, are included in each section of this document. The Cielo Computing Environment, along with the ACE mappings, has been issued and reviewed throughout the tri-Lab community.

  2. Towards Multi Label Text Classification through Label Propagation

    Directory of Open Access Journals (Sweden)

    Shweta C. Dharmadhikari

    2012-06-01

    Full Text Available Classifying text data has been an active area of research for a long time. Text document is multifaceted object and often inherently ambiguous by nature. Multi-label learning deals with such ambiguous object. Classification of such ambiguous text objects often makes task of classifier difficult while assigning relevant classes to input document. Traditional single label and multi class text classification paradigms cannot efficiently classify such multifaceted text corpus. Through our paper we are proposing a novel label propagation approach based on semi supervised learning for Multi Label Text Classification. Our proposed approach models the relationship between class labels and also effectively represents input text documents. We are using semi supervised learning technique for effective utilization of labeled and unlabeled data for classification. Our proposed approach promises better classification accuracy and handling of complexity and elaborated on the basis of standard datasets such as Enron, Slashdot and Bibtex.

  3. Radio labeling with pre-assigned frequencies

    NARCIS (Netherlands)

    Bodlaender, H.L.; Broersma, H.J.; Fomin, F.V.; Pyatkin, A.V.; Woeginer, G.J.

    2007-01-01

    A radio labeling of a graph G is an assignment of pairwise distinct, positive integer labels to the vertices of G such that labels of adjacent vertices differ by at least 2. The radio labeling problem (RL) consists in determining a radio labeling that minimizes the maximum label that is used (the so

  4. Radio labeling with pre-assigned frequencies

    NARCIS (Netherlands)

    Bodlaender, H.L.; Broersma, H.J.; Fomin, F.V.; Pyatkin, A.V.; Woeginer, G.J.

    2002-01-01

    A radio labeling of a graph G is an assignment of pairwise distinct, positive integer labels to the vertices of G such that labels of adjacent vertices differ by at least 2. The radio labeling problem (RL) consists in determining a radio labeling that minimizes the maximum label that is used (the

  5. Radio labeling with pre-assigned frequencies

    NARCIS (Netherlands)

    Bodlaender, H.L.; Broersma, Haitze J.; Fomin, F.V.; Pyatkin, A.V.; Woeginger, Gerhard

    2002-01-01

    A radio labeling of a graph $G$ is an assignment of pairwise distinct, positive integer labels to the vertices of $G$ such that labels of adjacent vertices differ by at least $2$. The radio labeling problem (\\mbox{\\sc RL}) consists in determining a radio labeling that minimizes the maximum label

  6. Quantitative amino acid profiling and stable isotopically labeled amino acid tracer enrichment used for in vivo human systemic and tissue kinetics measurements

    DEFF Research Database (Denmark)

    Bornø, Andreas; van Hall, Gerrit

    2014-01-01

    /ion exchange, derivatized using a phenylisothiocyanate reagent and each amino acid was quantitated with its own stable isotopically labeled internal standard (uniformly labeled-(13)C/(15)N). The method was validated according to general recommendations for chromatographic analytical methods. The calibration...... and plasma were 4.4 and 0.8%, and the interday variability was 3.4% and the recovery was 90.5%, respectively. In conclusion, we have developed and validated a method for quantitative amino acid profiling that meets the requirements for systemic and tissue human in vivo amino acid and protein turnover...

  7. Ranking with uncertain labels and its applications

    Institute of Scientific and Technical Information of China (English)

    YAN Shuicheng; WANG Huan; LIU Jianzhuang; TANG Xiao'ou; Thomas S.Huang

    2007-01-01

    The techniques for image analysis and classification generally consider the image sample labels fixed and without uncertainties.The rank regression problem studied in this paper is based on the training samples with uncertain labels,which often is the case for the manual estimated image labels.A core ranking model is designed first as the bilinear fusing of multiple candidate kernels.Then,the parameters for feature selection and kernel selection are learned simultaneously by maximum a posteriori for given samples and uncertain labels.The provable convergency Expectation Maximization(EM)method is used for inferring these parameters in an iterative manner.The effectiveness of the proposed algorithm is finally validated by the extensive experiments on age ranking task and human trackingtask.The popular FG-NET and the large scale Yamaha aging database are used for the age estimation experiments,and our algorithm outperforms those state-of-the-art algorithms ever reported by other interrelated literatures significantly.The experiment result of human tracking task also validates its advantage over conventional linear regression algorithm.

  8. THE SCHOOL PLANT GUIDE FOR PLANNING SCHOOL PLANTS OF PENNSYLVANIA. ARCHITECTURAL DESIGN REQUIREMENTS AND GENERAL, ELECTRIC, HEATING AND VENTILATING, AND PLUMBING STANDARDS.

    Science.gov (United States)

    Pennsylvania State Dept. of Public Instruction, Harrisburg.

    A GUIDE COVERING ARCHITECTURAL DESIGN REQUIREMENTS, ELECTRIC, HEATING AND VENTILATING, AND PLUMBING STANDARDS AS APPROVED BY THE STATE BOARD OF EDUCATION IN 1966. THE FOLLOWING MINIMUM STANDARD FOR NEW BUILDING, ALTERATIONS, AND ADDITIONS ARE OUTLINED--(1) SPATIAL ENVIRONMENTAL FACTORS, SUCH AS CEILING HEIGHTS, INTERIOR SANITARY FACILITIES, ROOMS…

  9. Quantifying emphysema extent from weakly labeled CT scans of the lungs using label proportions learning

    DEFF Research Database (Denmark)

    2016-01-01

    Quantification of emphysema extent is important in diagnosing and monitoring patients with chronic obstructive pulmonary disease (COPD). Several studies have shown that emphysema quantification by supervised texture classification is more robust and accurate than traditional densitometry. Current...... techniques require highly time consuming manual annotations of patches or use only weak labels indicating overall disease status (e.g, COPD or healthy). We show how visual scoring of regional emphysema extent can be exploited in a learning with label proportions (LLP) framework to both predict presence...

  10. Facial age estimation by learning from label distributions.

    Science.gov (United States)

    Geng, Xin; Yin, Chao; Zhou, Zhi-Hua

    2013-10-01

    One of the main difficulties in facial age estimation is that the learning algorithms cannot expect sufficient and complete training data. Fortunately, the faces at close ages look quite similar since aging is a slow and smooth process. Inspired by this observation, instead of considering each face image as an instance with one label (age), this paper regards each face image as an instance associated with a label distribution. The label distribution covers a certain number of class labels, representing the degree that each label describes the instance. Through this way, one face image can contribute to not only the learning of its chronological age, but also the learning of its adjacent ages. Two algorithms, named IIS-LLD and CPNN, are proposed to learn from such label distributions. Experimental results on two aging face databases show remarkable advantages of the proposed label distribution learning algorithms over the compared single-label learning algorithms, either specially designed for age estimation or for general purpose.

  11. Microfluidic Radiometal Labeling Systems for Biomolecules

    Energy Technology Data Exchange (ETDEWEB)

    Reichert, D E; Kenis, P J. A.

    2011-12-29

    In a typical labeling procedure with radiometals, such as Cu-64 and Ga-68; a very large (~ 100-fold) excess of the non-radioactive reactant (precursor) is used to promote rapid and efficient incorporation of the radioisotope into the PET imaging agent. In order to achieve high specific activities, careful control of reaction conditions and extensive chromatographic purifications are required in order to separate the labeled compounds from the cold precursors. Here we propose a microfluidic approach to overcome these problems, and achieve high specific activities in a more convenient, semi-automated fashion and faster time frame. Microfluidic reactors, consisting of a network of micron-sized channels (typical dimensions in the range 10 - 300¼m), filters, separation columns, electrodes and reaction loops/chambers etched onto a solid substrate, are now emerging as an extremely useful technology for the intensification and miniaturization of chemical processes. The ability to manipulate, process and analyze reagent concentrations and reaction interfaces in both space and time within the channel network of a microreactor provides the fine level of reaction control that is desirable in PET radiochemistry practice. These factors can bring radiometal labeling, specifically the preparation of radio-labeled biomolecules such as antibodies, much closer to their theoretical maximum specific activities.

  12. AIRWAY LABELING USING A HIDDEN MARKOV TREE MODEL

    Science.gov (United States)

    Ross, James C.; Díaz, Alejandro A.; Okajima, Yuka; Wassermann, Demian; Washko, George R.; Dy, Jennifer; San José Estépar, Raúl

    2014-01-01

    We present a novel airway labeling algorithm based on a Hidden Markov Tree Model (HMTM). We obtain a collection of discrete points along the segmented airway tree using particles sampling [1] and establish topology using Kruskal’s minimum spanning tree algorithm. Following this, our HMTM algorithm probabilistically assigns labels to each point. While alternative methods label airway branches out to the segmental level, we describe a general method and demonstrate its performance out to the subsubsegmental level (two generations further than previously published approaches). We present results on a collection of 25 computed tomography (CT) datasets taken from a Chronic Obstructive Pulmonary Disease (COPD) study. PMID:25436039

  13. Patient enablement requires physician empathy: a cross-sectional study of general practice consultations in areas of high and low socioeconomic deprivation in Scotland

    Directory of Open Access Journals (Sweden)

    Mercer Stewart W

    2012-02-01

    Full Text Available Abstract Background Patient 'enablement' is a term closely aligned with 'empowerment' and its measurement in a general practice consultation has been operationalised in the widely used patient enablement instrument (PEI, a patient-rated measure of consultation outcome. However, there is limited knowledge regarding the factors that influence enablement, particularly the effect of socio-economic deprivation. The aim of the study is to assess the factors influencing patient enablement in GP consultations in areas of high and low deprivation. Methods A questionnaire study was carried out on 3,044 patients attending 26 GPs (16 in areas of high socio-economic deprivation and 10 in low deprivation areas, in the west of Scotland. Patient expectation (confidence that the doctor would be able to help was recorded prior to the consultation. PEI, GP empathy (measured by the CARE Measure, and a range of other measures and variables were recorded after the consultation. Data analysis employed multi-level modelling and multivariate analyses with the PEI as the dependant variable. Results Although numerous variables showed a univariate association with patient enablement, only four factors were independently predictive after multilevel multivariate analysis; patients with multimorbidity of 3 or more long-term conditions (reflecting poor chronic general health, and those consulting about a long-standing problem had reduced enablement scores in both affluent and deprived areas. In deprived areas, emotional distress (GHQ-caseness had an additional negative effect on enablement. Perceived GP empathy had a positive effect on enablement in both affluent and deprived areas. Maximal patient enablement was never found with low empathy. Conclusions Although other factors influence patient enablement, the patients' perceptions of the doctors' empathy is of key importance in patient enablement in general practice consultations in both high and low deprivation settings.

  14. Quality assurance review of training in oral and maxillofacial surgery by the General Medical Council: areas of good practice, requirements, and recommendations.

    Science.gov (United States)

    Sandhu, Davinder P S; Dover, Michael Stephen; Lay, Sarah

    2016-04-01

    The purpose of this paper is to disseminate the outcome of the 2012/13 UK-wide quality assurance review of postgraduate training in oral and maxillofacial surgery (OMFS) by the General Medical Council (GMC), as part of its review of small specialties. OMF surgeons need to be aware of the evidence on which the conclusions are based, and to know about the strengths of the specialty and the areas for future development so that postgraduate training, and ultimately the outcomes for patients, can be improved. This paper, by the authors involved in the review, summarises the salient points and is not a verbatim report. Copyright © 2016. Published by Elsevier Ltd.

  15. 76 FR 75809 - Prior Label Approval System: Generic Label Approval

    Science.gov (United States)

    2011-12-05

    ... Food Standards and Labeling Policy Book; does not bear any special claims, such as quality claims... addition, deletion, or amendment of recipe suggestions for the product; j. Any change in punctuation; k... Policy Book, and questions and answers on various topics, such as irradiation and the labeling...

  16. Quality Evaluation Model for Map Labeling

    Institute of Scientific and Technical Information of China (English)

    FAN Hong; ZHANG Zuxun; DU Daosheng

    2005-01-01

    This paper discusses and sums up the basic criterions of guaranteeing the labeling quality and abstracts the four basic factors including the conflict for a label with a label, overlay for label with the features, position's priority and the association for a label with its feature. By establishing the scoring system, a formalized four-factors quality evaluation model is constructed. Last, this paper introduces the experimental result of the quality evaluation model applied to the automatic map labeling system-MapLabel.

  17. Bolus-tracking arterial spin labelling: theoretical and experimental results

    Science.gov (United States)

    Kelly, M. E.; Blau, C. W.; Kerskens, C. M.

    2009-03-01

    Arterial spin labelling (ASL) is a magnetic resonance imaging (MRI) technique that can be used to provide a quantitative assessment of cerebral perfusion. Despite the development of a number of theoretical models to facilitate quantitative ASL, some key challenges still remain. The purpose of this study is to develop a novel quantitative ASL method based on a macroscopic model that reduces the number of variables required to describe the physiological processes involved. To this end, a novel Fokker-Planck equation consisting of stochastically varying macroscopic variables was derived from a general Langevin equation. ASL data from the rat brain was acquired using a bolus-tracking ASL protocol where a bolus of labelled spins flowing from an inversion plane in the neck into an imaging plane in the brain can be observed. Bolus durations of 1.5 s, 2.0 s and 3.0 s were used and the solution to the Fokker-Planck equation for the boundary conditions of bolus-tracking ASL was fitted to the experimental data using a least-squares fit. The mean transit time (MTT) and capillary transit time (CTT) were calculated from the first and second moments of the resultant curve respectively and the arterial transit time (ATT) was calculated by subtracting the CTT from the MTT. The average MTT, CTT and ATT values were 1.75 ± 0.22 s, 1.43 ± 0.12 s and 0.32 ± 0.04 s respectively. In conclusion, a new ASL protocol has been developed by combining the theoretical model with ASL experiments. The technique has the unique ability to provide solutions for varying bolus volumes and the generality of the new model is demonstrated by the derivation of additional solutions for the continuous and pulsed ASL (CASL and PASL) techniques.

  18. 'GMO-Free' labels - enhancing transparency or deceiving consumers?

    OpenAIRE

    Henseleit, Meike; Kubitzki, Sabine; HERRMANN, ROLAND

    2009-01-01

    Consumers, particularly in industrialised countries, are concerned about the application of genetic engineering in food production. There are considerations in many nations worldwide to introduce legal regulations to label food as free of genetically modified organisms (GMOs) in order to enable producers to better promote such products. However, requirements for labelling food products as ‘GMO-free’ can be very different, and therefore it is questionable whether consumers’ understanding of ‘G...

  19. Snake oil salesmen or purveyors of knowledge: off-label promotions and the commercial speech doctrine.

    Science.gov (United States)

    Bagley, Constance E; Mitts, Joshua; Tinsley, Richard J

    2013-01-01

    The Second Circuit's December 2012 decision in United States v. Caronia striking down the prohibition on off-label marketing of pharmaceutical drugs has profound implications for economic regulation in general, calling into question the constitutionality of restrictions on the offer and sale of securities under the Securities Act of 1933, the solicitation of shareholder proxies and periodic reporting under the Securities Exchange Act of 1934, mandatory labels on food, tobacco, and pesticides, and a wide range of privacy protections. In this Article we suggest that Caronia misconstrues the Supreme Court's holding in Sorrell v. IMS Health, which was motivated by concerns of favoring one industry participant over another rather than a desire to return to the anti-regulator fervor of the Lochner era. Reexamining the theoretical justification for limiting truthful commercial speech shows that a more nuanced approach to regulating off-label marketing with the purpose of promoting public health and safety would pass constitutional muster. We argue that as long as the government both has a rational basis for subjecting a particular industry to limits on commercial speech intended to further a legitimate public interest, rather than unfounded paternalism, and does not discriminate against disfavored industry participants, those limits should be subject to intermediate scrutiny under the Central Hudson standard. We believe that our articulation of the commercial speech doctrine post-Sorrell will help resolve the current split in the Circuits on the appropriate standard of review in cases involving both restrictions on commercial speech and mandated speech. Finally, we critique the FDA's 2011 Guidance for Responding to Unsolicited Requests for Off- Label Information (draft) and present a proposal for new rules for regulating the off-label marketing of pharmaceutical drugs based on transparency, the sophistication of the listener and the type of information offered, and the

  20. Fluorescence labelling as tool for zeolite particle tracking in nanoremediation approaches

    Energy Technology Data Exchange (ETDEWEB)

    Gillies, Glenn; Mackenzie, Katrin; Kopinke, Frank-Dieter; Georgi, Anett

    2016-04-15

    Colloidal Fe-zeolites such as Fe-BEA-35 are currently under study as new adsorbent and catalyst materials for in-situ chemical oxidation with H{sub 2}O{sub 2}. As for nanoremediation in general, the availability of suitable particle detection methods is a requirement for successful process development and particle tracing. Detection and distinguishing between natural colloids and introduced particles with a similar composition are a challenge. By means of fluorescence labelling, a highly specific detection option for Fe-BEA-35 was developed. ‘Ship-in-a-bottle’ synthesis of fluorescein within the zeolite pores, which was applied for the first time for a BEA type zeolite, provides a product with stable and non-extractable fluorescence. When the fluorescent labelled zeolite is added at a concentration of 1 wt.% referring to the total zeolite mass, a very low detection limit of 1 mg/L of total zeolite is obtained. Compared to commonly applied turbidity measurements, detection via fluorescence labelling is much more specific and sensitive. Fluorescence is only marginally affected by carboxymethyl cellulose, which is frequently applied as stabilizer in application suspensions but will be depleted upon contact with H{sub 2}O{sub 2}. Transport properties of fluorescent labelled and non-labelled Fe-zeolite particles are in agreement as determined in a column study with quartz sand and synthetic groundwater (classified as very hard). - Highlights: • Fluorescent BEA zeolite was prepared for first time by ‘ship-in-a-bottle’ synthesis. • Fluorescein synthesized inside zeolite channels is stable and non-extractable. • Detection limit of Fe-zeolite particles in suspension with 1 wt.% fluorescent zeolite is 1 mg/L. • Transport properties of fluorescent and Fe-loaded BEA particles are identical.