WorldWideScience

Sample records for general access structures

  1. Image size invariant visual cryptography for general access structures subject to display quality constraints.

    Science.gov (United States)

    Lee, Kai-Hui; Chiu, Pei-Ling

    2013-10-01

    Conventional visual cryptography (VC) suffers from a pixel-expansion problem, or an uncontrollable display quality problem for recovered images, and lacks a general approach to construct visual secret sharing schemes for general access structures. We propose a general and systematic approach to address these issues without sophisticated codebook design. This approach can be used for binary secret images in non-computer-aided decryption environments. To avoid pixel expansion, we design a set of column vectors to encrypt secret pixels rather than using the conventional VC-based approach. We begin by formulating a mathematic model for the VC construction problem to find the column vectors for the optimal VC construction, after which we develop a simulated-annealing-based algorithm to solve the problem. The experimental results show that the display quality of the recovered image is superior to that of previous papers.

  2. Open-access ultrasound referrals from general practice.

    LENUS (Irish Health Repository)

    Hughes, P

    2015-03-01

    Direct access referral for radiological investigations from General Practice (GP) provides an indispensable diagnostic tool and avoids the inherently long waiting time that referral through a hospital based specialty would entail. Improving access to hospital based radiology services is one of Health Information and Quality Authority\\'s key recommendations in its report on patient referrals from general practice. This study aimed to review all GP referrals for ultrasound investigations to a tertiary referral teaching hospital over a seven month period with respect to their demographics, waiting times and diagnostic outcomes. 1,090 ultrasounds originating in general practice were carried out during the study period. Positive findings were recorded in 332 (30.46%) examinations. The median waiting time from receipt of referral to the diagnostic investigation was 56 days (range 16 - 91 years). 71 (6.5%) patients had follow-up imaging investigations while recommendation for hospital based specialty referral was made in 35 cases (3.2%). Significant findings included abdominal aortic aneurysms, metastatic disease and lymphoma. Direct access to ultrasound for general practitioners allows the referring physician to make an informed decision with regard to the need for specialist referral. We believe these findings help support the case for national direct access to diagnostic ultrasound for general practitioners.

  3. On the generalization of attitude accessibility after repeated attitude expression

    Science.gov (United States)

    Spruyt, Adriaan; Fazio, Russell H.; Hermans, Dirk

    2016-01-01

    Abstract The more accessible an attitude is, the stronger is its influence on information processing and behavior. Accessibility can be increased through attitude rehearsal, but it remains unknown whether attitude rehearsal also affects the accessibility of related attitudes. To investigate this hypothesis, participants in an experimental condition repeatedly expressed their attitudes towards exemplars of several semantic categories during an evaluative categorization task. Participants in a control condition performed a non‐evaluative task with the same exemplars and evaluated unrelated attitude objects. After a 30‐minute interval, participants in the experimental condition were faster than controls to evaluate not only the original exemplars but also novel exemplars of the same categories. This finding suggests that the effect of attitude rehearsal on accessibility generalizes to attitudes towards untrained but semantically related attitude objects. © 2016 The Authors. European Journal of Social Psychology published by John Wiley & Sons, Ltd. PMID:28701803

  4. 15 CFR 2008.15 - General restrictions on access.

    Science.gov (United States)

    2010-01-01

    ... 15 Commerce and Foreign Trade 3 2010-01-01 2010-01-01 false General restrictions on access. 2008.15 Section 2008.15 Commerce and Foreign Trade Regulations Relating to Foreign Trade Agreements OFFICE OF THE UNITED STATES TRADE REPRESENTATIVE REGULATIONS TO IMPLEMENT E.O. 12065; OFFICE OF THE UNITED...

  5. Generalized structural theory of freezing

    International Nuclear Information System (INIS)

    Yussouff, M.

    1980-10-01

    The first-principles order parameter theory of freezing, proposed in an earlier work, has been successful in yielding quantitative agreement with known freezing parameters for monoatomic liquids forming solids with one atom per unit cell. A generalization of this theory is presented here to include the effects of a basis set of many atoms per unit cell. The basic equations get modified by the 'density structure factors' fsub(i) which arise from the density variations within the unit cell. Calculations are presented for the important case of monoatomic liquids freezing into hexagonal close packed solids. It is concluded that all freezing transitions can be described by using structural correlations in the liquid instead of the pair potential; and that the three body correlations are important in deciding the type of solid formed after freezing. (author)

  6. Open Access to General Practice Was Associated with Burnout among General Practitioners.

    Science.gov (United States)

    Vedsted, Peter; Sokolowski, Ineta; Olesen, Frede

    2013-01-01

    Walk-in open access in general practice may influence the general practitioner's (GP's) work, but very little research has been done on the consequences. In this study from Danish general practice, we compare the prevalence of burnout between GPs with a walk-in open access and those without. In a questionnaire study (2004), we approached all 458 active GPs in the county of Aarhus, Denmark, and 376 (82.8%) GPs returned the questionnaire. Walk-in open access was defined as at least 30 minutes every weekday where patients could attend practice without an appointment. Burnout was measured by the Maslach Burnout Inventory. Analyses using logistic regression were adjusted for gender, age, marital status, job satisfaction, minutes per consultation, practice organisation, working hours, number of listed patients per GP, number of contacts per GP, continuing medical education- (CME-) activities, and clusters of GPs. In all, 8% of GPs had open access and the prevalence of burnout was 24%. GPs with walk-in open access were more likely to suffer from burnout. Having open access was associated with a 3-fold increased likelihood of burnout (OR = 3.1 (95% CI: 1.1-8.8, P = 0.035)). Although the design cannot establish causality, it is recommended to closely monitor possible negative consequences of open access in general practice.

  7. Functional Generalized Structured Component Analysis.

    Science.gov (United States)

    Suk, Hye Won; Hwang, Heungsun

    2016-12-01

    An extension of Generalized Structured Component Analysis (GSCA), called Functional GSCA, is proposed to analyze functional data that are considered to arise from an underlying smooth curve varying over time or other continua. GSCA has been geared for the analysis of multivariate data. Accordingly, it cannot deal with functional data that often involve different measurement occasions across participants and a large number of measurement occasions that exceed the number of participants. Functional GSCA addresses these issues by integrating GSCA with spline basis function expansions that represent infinite-dimensional curves onto a finite-dimensional space. For parameter estimation, functional GSCA minimizes a penalized least squares criterion by using an alternating penalized least squares estimation algorithm. The usefulness of functional GSCA is illustrated with gait data.

  8. General knowledge structure for diagnosis

    International Nuclear Information System (INIS)

    Steinar Brendeford, T.

    1996-01-01

    At the OECD Halden Reactor Project work has been going on for several years in the field of automatic fault diagnosis for nuclear power plants. Continuing this work, studies are now carried out to combine different diagnostic systems within the same framework. The goal is to establish a general knowledge structure for diagnosis applied to a NPP process. Such a consistent and generic storage of knowledge will lighten the task of combining different diagnosis techniques. An integration like this is expected to increase the robustness and widen the scope of the diagnosis. Further, verification of system reliability and on-line explanations of hypotheses can be helped. Last but not least there is a potential in reuse of both specific and generic knowledge. The general knowledge framework is also a prerequisite for a successful integration of computerized operator support systems within the process supervision and control complex. Consistency, verification and reuse are keywords also in this respect. Systems that should be considered for integration are; automatic control, computerized operator procedures, alarm - and alarm filtering, signal validation, diagnosis and condition based maintenance. This paper presents three prototype diagnosis systems developed at the OECD Halden Reactor Project. A software arrangement for process simulation with these three systems attached in parallel is briefly described. The central part of this setup is a 'blackboard' system to be used for representing shared knowledge. Examples of such knowledge representations are included in the paper. The conclusions so far in this line of work are only tentative. The studies of existing methodologies for diagnosis, however, show a potential for several generalizations to be made in knowledge representation and use. (author). 14 refs, 6 figs

  9. General knowledge structure for diagnosis

    Energy Technology Data Exchange (ETDEWEB)

    Steinar Brendeford, T [Institutt for Energiteknikk, Halden (Norway). OECD Halden Reaktor Projekt

    1997-12-31

    At the OECD Halden Reactor Project work has been going on for several years in the field of automatic fault diagnosis for nuclear power plants. Continuing this work, studies are now carried out to combine different diagnostic systems within the same framework. The goal is to establish a general knowledge structure for diagnosis applied to a NPP process. Such a consistent and generic storage of knowledge will lighten the task of combining different diagnosis techniques. An integration like this is expected to increase the robustness and widen the scope of the diagnosis. Further, verification of system reliability and on-line explanations of hypotheses can be helped. Last but not least there is a potential in reuse of both specific and generic knowledge. The general knowledge framework is also a prerequisite for a successful integration of computerized operator support systems within the process supervision and control complex. Consistency, verification and reuse are keywords also in this respect. Systems that should be considered for integration are; automatic control, computerized operator procedures, alarm - and alarm filtering, signal validation, diagnosis and condition based maintenance. This paper presents three prototype diagnosis systems developed at the OECD Halden Reactor Project. A software arrangement for process simulation with these three systems attached in parallel is briefly described. The central part of this setup is a `blackboard` system to be used for representing shared knowledge. Examples of such knowledge representations are included in the paper. The conclusions so far in this line of work are only tentative. The studies of existing methodologies for diagnosis, however, show a potential for several generalizations to be made in knowledge representation and use. (author). 14 refs, 6 figs.

  10. Multiple access chaotic digital communication based on generalized synchronization

    International Nuclear Information System (INIS)

    Lu Junguo

    2005-01-01

    A novel method for multiple access chaotic digital communication based on the concept of chaos generalized synchronization and the on-line least square method is proposed. This method can be used for transmitting multiple digital information signals concurrently. We illustrate the method using a Lorenz system driving a Chua's circuit and then examine the robustness of the proposed method with respect to noise in communication channel

  11. Access Structures in a Standard Translation Dictionary | Louw ...

    African Journals Online (AJOL)

    The access structure is the primary guide structure in the central texts of any standard translation dictionary. The metalexicographical term "guide structures" refers to the set of structures that provides a framework within which the accessibility and availability of information types in the dictionary can be evaluated. The access ...

  12. Open Access to General Practice Was Associated with Burnout among General Practitioners

    DEFF Research Database (Denmark)

    Vedsted, Peter; Sokolowski, Ineta; Olesen, Frede

    2013-01-01

    Walk-in open access in general practice may influence the general practitioner's (GP's) work, but very little research has been done on the consequences. In this study from Danish general practice, we compare the prevalence of burnout between GPs with a walk-in open access and those without....... In a questionnaire study (2004), we approached all 458 active GPs in the county of Aarhus, Denmark, and 376 (82.8%) GPs returned the questionnaire. Walk-in open access was defined as at least 30 minutes every weekday where patients could attend practice without an appointment. Burnout was measured by the Maslach...... Burnout Inventory. Analyses using logistic regression were adjusted for gender, age, marital status, job satisfaction, minutes per consultation, practice organisation, working hours, number of listed patients per GP, number of contacts per GP, continuing medical education- (CME-) activities, and clusters...

  13. UDAS - data structure and data access routine

    International Nuclear Information System (INIS)

    Kroiss, H.

    1987-08-01

    The UDAS data format was designed to have the following properties: The structure of a data file should, if possible, 1. be simple and transparent, 2. contain all information required for complete interpretation of this dataset, 3. be flexible to allow fast and simple implementation of extensions and modifications, 4. avoid pointers, offsets, fixed type specifications, fixed sequences and fixed-length structures whenever possible, since such elements complicate the handling of a dataset and, furthermore, restrict the possibilities of the data acquisition system, 5. contain few different control block types and not prescribe fixed definitions or interpretations of the control blocks, and 6. be organized in records to allow fast access. Each record should only contain a single type of data in order to facilitate conversion to other computer systems. It was largely possible to satisfy all of the above requirements with the UDAS data format, mainly by means of the character representation (ASCII) of the control and description blocks. The data format, which is composed of only description and data blocks, thereby became very straightforward and flexible. (orig.)

  14. Living large: the experiences of large-bodied women when accessing general practice services

    Directory of Open Access Journals (Sweden)

    Russell N

    2013-09-01

    Full Text Available INTRODUCTION: Numerous studies report high levels of stigma and discrimination experienced by obese/overweight women within the health care system and society at large. Despite general practice being the most utilised point of access for health care services, there is very little international or national exploration of the experiences of large-bodied women (LBW accessing these services. The aim of this study was to explore LBW's experiences of accessing general practice services in New Zealand. METHODS: This is a qualitative, descriptive, feminist study. Local advertising for participants resulted in eight self-identified, large-bodied women being interviewed. A post-structural feminist lens was applied to the data during thematic analysis. FINDINGS: The women in this study provided examples of verbal insults, inappropriate humour, negative body language, unmet health care needs and breaches of dignity from health care providers in general practice. Seven themes were identified: early experiences of body perception, confronting social stereotypes, contending with feminine beauty ideals, perceptions of health, pursuing health, respecting the whole person, and feeling safe to access care. CONCLUSION: Pressure for body size vigilance has, in effect, excluded the women in this study from the very locations of health that they are 'encouraged' to attend-including socialising and exercising in public, screening opportunities that require bodily exposure, and accessing first point of care health services.

  15. Structuring diabetes care in general practices: many improvements, remaining challenges.

    LENUS (Irish Health Repository)

    Jennings, S

    2009-08-07

    BACKGROUND: For people with type 2 diabetes to enjoy improved longevity and quality of life, care needs to be organised in a systematic way. AIM: To test if processes and intermediate outcomes for patients with type 2 diabetes changed with the move to structured care in general practice shared with secondary care. METHODS: An audit of process and intermediate outcomes for patients with type 2 diabetes before and after the change to structured care in 10 Dublin general practices shared with secondary care four years on. RESULTS: Structured diabetes care in general practice has led to more dedicated clinics improved processes of care and increased access to multidisciplinary expertise. Improvement in blood pressure control, the use of aspirin and the use of lipid lowering agents indicate a significant decrease in absolute risk of vascular events for this population. CONCLUSIONS: Structured care in general practice improves intermediate outcomes for people with type 2 diabetes. Further improvements need to be made to reach international targets.

  16. Access to general practice for Pacific peoples: a place for cultural competency.

    Science.gov (United States)

    Ludeke, Melissa; Puni, Ronald; Cook, Lynley; Pasene, Maria; Abel, Gillian; Sopoaga, Faafetai

    2012-06-01

    Access to primary health care services has been identified as a problem for Pacific peoples. Although cost is the most frequently cited barrier to Pacific service utilisation, some research has indicated that access may also be influenced by features of mainstream primary care services. This study aimed to identify features of mainstream general practice services that act as barriers to accessing these services for Pacific peoples in order to explore strategies that providers could adopt to enable their practices to be more welcoming, accessible and appropriate for Pacific peoples. Pacific participants were recruited through Pacific networks known to Pegasus Health and via 'snowball' sampling. In total, 20 participants participated in one of three focus groups. A semi-structured interview explored the participants' views and experiences of mainstream general practice care. Thematic analysis was utilised to interpret the data. The analysis revealed five themes highlighting non-financial features of mainstream general practice services that may influence the availability and acceptability of these services to Pacific peoples: language and communication; rushed consultations; appointment availability; reception; and Pacific presence. The findings indicate that all personnel within the primary care setting have the ability to directly engage in the improvement of the health status of Pacific peoples in New Zealand by developing cultural competency and incorporating flexibility and diversity into the care and service they provide.

  17. Structure for common access and support of fuel cell stacks

    Science.gov (United States)

    Walsh, Michael M.

    2000-01-01

    A structure provides common support and access to multiple fuel cells externally mounted thereto. The structure has openings leading to passages defined therein for providing the access. Various other fuel cell power system components are connected at the openings, such as reactant and coolant sources.

  18. General Controls Over the Electronic Document Access System

    National Research Council Canada - National Science Library

    2000-01-01

    ...) system as part of the DoD Paper-Free Contracting Initiative. EDA contributes to the initiative by digitizing paper documents and offering web-based read-only access to official contracting, finance and accounting documents...

  19. Expanding access to rheumatology care: the rheumatology general practice toolbox.

    LENUS (Irish Health Repository)

    Conway, R

    2015-02-01

    Management guidelines for many rheumatic diseases are published in specialty rheumatology literature but rarely in general medical journals. Musculoskeletal disorders comprise 14% of all consultations in primary care. Formal post-graduate training in rheumatology is limited or absent for many primary care practitioners. Primary care practitioners can be trained to effectively treat complex diseases and have expressed a preference for interactive educational courses. The Rheumatology General Practice (GP) Toolbox is an intensive one day course designed to offer up to date information to primary care practitioners on the latest diagnostic and treatment guidelines for seven common rheumatic diseases. The course structure involves a short lecture on each topic and workshops on arthrocentesis, joint injection and DXA interpretation. Participants evaluated their knowledge and educational experience before, during and after the course. Thirty-two primary care practitioners attended, who had a median of 13 (IQR 6.5, 20) years experience in their specialty. The median number of educational symposia attended in the previous 5 years was 10 (IQR-5, 22.5), with a median of 0 (IQR 0, 1) in rheumatology. All respondents agreed that the course format was appropriate. Numerical improvements were demonstrated in participant\\'s confidence in diagnosing and managing all seven common rheumatologic conditions, with statistically significant improvements (p < 0.05) in 11 of the 14 aspects assessed. The Rheumatology Toolbox is an effective educational method for disseminating current knowledge in rheumatology to primary care physicians and improved participant\\'s self-assessed competence in diagnosis and management of common rheumatic diseases.

  20. Primary care access for mental illness in Australia: Patterns of access to general practice from 2006 to 2016.

    Science.gov (United States)

    Farrer, Louise M; Walker, Jennie; Harrison, Christopher; Banfield, Michelle

    2018-01-01

    General practice has an important role within the Australian healthcare system to provide access to care and effective management of chronic health conditions. However, people with serious mental illness experience challenges associated with service access. The current paper seeks to examine drivers of access to general practice for people with common and serious mental disorders, compared with people who access care for type II diabetes, a common physical health problem managed in general practice. The Bettering the Evaluation and Care of Health (BEACH) programme provides the most comprehensive and objective measurement of general practitioner activity in Australia. Using BEACH data, this study compared general practice encounters for depression, anxiety, bipolar disorder, schizophrenia, and type II diabetes during a 10-year period between 2006 and 2016. Analysis revealed more frequent encounters for depression compared to anxiety, and a higher representation of women in encounters for bipolar disorder compared to men. The relationship between number of encounters and patient age was strongly associated with the life course and mortality characteristics associated with each disorder. The findings highlight specific challenges associated with access to primary care for people with serious mental illness, and suggest areas of focus to improve the ability of these patients to access and navigate the health system.

  1. General practitioner access to gastroscopy: is 'censorship' valuable?

    Science.gov (United States)

    Mourad, F H; Taylor, T M; Fairclough, P D; Farthing, M J

    1998-04-01

    An audit was carried out on the activities of a one stop clinic where patients referred by GPs for endoscopy are first interviewed by a gastroenterologist, directly before the procedure. Such a barrier to open access endoscopy did not seem to reduce the workload or the rate of normal examinations.

  2. 50 CFR 660.331 - Limited entry and open access fisheries-general.

    Science.gov (United States)

    2010-10-01

    ... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false Limited entry and open access fisheries... West Coast Groundfish Fisheries § 660.331 Limited entry and open access fisheries—general. All... entry and open access fisheries, except such fishing by treaty Indian tribes as may be separately...

  3. Generalized functions, convergence structures, and their applications

    CERN Document Server

    Pap, Endre; Pilipović, Stevan; Vladimirov, Vasilij; International Conference "Generalized functions, convergence structures and their applications" (GFCA-87)

    1988-01-01

    This Proceedings consists of a collection of papers presented at the International Conference "Generalized functions, convergence structures and their applications" held from June 23-27, 1987 in Dubrovnik, Yugoslavia (GFCA-87): 71 participants from 21 countr~es from allover the world took part in the Conference. Proceedings reflects the work of the Conference. Plenary lectures of J. Burzyk, J. F. Colombeau, W. Gahler, H. Keiter, H. Komatsu, B. Stankovic, H. G. Tillman, V. S. Vladimirov provide an up-to-date account of the cur­ rent state of the subject. All these lectures, except H. G. Tillman's, are published in this volume. The published communications give the contemporary problems and achievements in the theory of generalized functions, in the theory of convergence structures and in their applications, specially in the theory of partial differential equations and in the mathematical physics. New approaches to the theory of generalized functions are presented, moti­ vated by concrete problems of applicat...

  4. Generalized impedances and wakes in asymmetric structures

    International Nuclear Information System (INIS)

    Heifets, S.; Wagner, A.; Zotter, B.

    1998-01-01

    In rotationally structures, the dominant m = 0 longitudinal impedance does not depend on the offsets of either the leading or the trailing particles, while the dominant m = 1 transverse impedance is proportional to the offset of the leading particles, while it is still independent of the offsets of the trailing ones. This behavior is no longer true in rotationally non-symmetric structures, where in general all impedances depend on the offsets of both the leading and the trailing particles. The same behavior is shown by wake functions and wake potentials. The concept of generalized impedances or generalized wake functions must be used to calculate the effect of leading particles on trailing ones with different offsets, each described by two transverse coordinates. This dependence of wake potentials on four additional parameters (two for each offset) would make their use very cumbersome. Fortunately, it was found that the transverse wake potentials can be separated into superpositions of dipolar components, which are proportional to the offset of the leading bunch, and quadrupolar components, which are proportional to the offset of the trailing particles. Higher multipole components are much smaller, and can be neglected for most structures without rotational symmetry. In this report, the authors derive analytical expressions for these multipolar components, which permits estimates of the size of the neglected terms. In particular, when structures have one or two transverse symmetry planes, the expressions simplify and explain the behavior of wake potentials which had been computed for rotationally non-symmetric structures

  5. Switch Based Opportunistic Spectrum Access for General Primary User Traffic Model

    KAUST Repository

    Gaaloul, Fakhreddine

    2012-06-18

    This letter studies cognitive radio transceiver that can opportunistically use the available channels of primary user (PU). Specifically, we investigate and compare two different opportunistic channel access schemes. The first scheme applies when the secondary user (SU) has access to only one channel. The second scheme, based on channel switching mechanism, applies when the SU has access to multiple channels but can at a given time monitor and access only one channel. For these access schemes, we derive the exact analytical results for the novel performance metrics of average access time and average waiting time under general PU traffic models.

  6. Switch Based Opportunistic Spectrum Access for General Primary User Traffic Model

    KAUST Repository

    Gaaloul, Fakhreddine; Alouini, Mohamed-Slim; Radaydeh, Redha M.; Yang, Hong-Chuan

    2012-01-01

    This letter studies cognitive radio transceiver that can opportunistically use the available channels of primary user (PU). Specifically, we investigate and compare two different opportunistic channel access schemes. The first scheme applies when the secondary user (SU) has access to only one channel. The second scheme, based on channel switching mechanism, applies when the SU has access to multiple channels but can at a given time monitor and access only one channel. For these access schemes, we derive the exact analytical results for the novel performance metrics of average access time and average waiting time under general PU traffic models.

  7. Efficient accesses of data structures using processing near memory

    Science.gov (United States)

    Jayasena, Nuwan S.; Zhang, Dong Ping; Diez, Paula Aguilera

    2018-05-22

    Systems, apparatuses, and methods for implementing efficient queues and other data structures. A queue may be shared among multiple processors and/or threads without using explicit software atomic instructions to coordinate access to the queue. System software may allocate an atomic queue and corresponding queue metadata in system memory and return, to the requesting thread, a handle referencing the queue metadata. Any number of threads may utilize the handle for accessing the atomic queue. The logic for ensuring the atomicity of accesses to the atomic queue may reside in a management unit in the memory controller coupled to the memory where the atomic queue is allocated.

  8. Unraveling hadron structure with generalized parton distributions

    Energy Technology Data Exchange (ETDEWEB)

    Andrei Belitsky; Anatoly Radyushkin

    2004-10-01

    The recently introduced generalized parton distributions have emerged as a universal tool to describe hadrons in terms of quark and gluonic degrees of freedom. They combine the features of form factors, parton densities and distribution amplitudes - the functions used for a long time in studies of hadronic structure. Generalized parton distributions are analogous to the phase-space Wigner quasi-probability function of non-relativistic quantum mechanics which encodes full information on a quantum-mechanical system. We give an extensive review of main achievements in the development of this formalism. We discuss physical interpretation and basic properties of generalized parton distributions, their modeling and QCD evolution in the leading and next-to-leading orders. We describe how these functions enter a wide class of exclusive reactions, such as electro- and photo-production of photons, lepton pairs, or mesons.

  9. Disparities in access to emergency general surgery care in the United States.

    Science.gov (United States)

    Khubchandani, Jasmine A; Shen, Connie; Ayturk, Didem; Kiefe, Catarina I; Santry, Heena P

    2018-02-01

    As fewer surgeons take emergency general surgery call and hospitals decrease emergency services, a crisis in access looms in the United States. We examined national emergency general surgery capacity and county-level determinants of access to emergency general surgery care with special attention to disparities. To identify potential emergency general surgery hospitals, we queried the database of the American Hospital Association for "acute care general hospital," with "surgical services," and "emergency department," and ≥1 "operating room." Internet search and direct contact confirmed emergency general surgery services that covered the emergency room 7 days a week, 24 hours a day. Geographic and population-level emergency general surgery access was derived from Geographic Information Systems and US Census. Of the 6,356 hospitals in the 2013 American Hospital Association database, only 2,811 were emergency general surgery hospitals. Counties with greater percentages of black, Hispanic, uninsured, and low-education individuals and rural counties disproportionately lacked access to emergency general surgery care. For example, counties above the 75th percentile of African American population (10.2%) had >80% odds of not having an emergency general surgery hospital compared with counties below the 25th percentile of African American population (0.6%). Gaps in access to emergency general surgery services exist across the United States, disproportionately affecting underserved, rural communities. Policy initiatives need to increase emergency general surgery capacity nationwide. Copyright © 2017 Elsevier Inc. All rights reserved.

  10. Direction dependent structures in general relativity

    International Nuclear Information System (INIS)

    Herberthson, M.

    1993-01-01

    This thesis deals with, within the theory of general relativity, asymptotic properties of certain types of space-times. Using conformal transformations, it is possible to describe asymptotic properties of a physical space-time in terms of the local behaviour of the new, rescaled space-time. One then uses so called direction dependent structures. We present two such structures and applications to them. One structure is used in the study of spacelike (or spatial) infinity. We discuss the asymptotic conditions on the gravitational and the electromagnetic field, especially the conditions put on directions corresponding to future and past null infinity. It is shown that these fields have desired physical properties. The other structure is used in connection with timelike infinity. Using this structure, we suggest a new definition of timelike infinity. This definition differs significantly from earlier definitions, and leads to the concept of asymptotically stationary space-times. We also suggest a definition of asymptotic flatness at future null infinity, and a definition of a black hole which is, in a sense, local. Both of these definitions fit nicely into the structure. (24 refs.)

  11. Concrete structures under impact loading: general aspects

    Directory of Open Access Journals (Sweden)

    Cornelia Baeră

    2016-09-01

    Full Text Available Dynamic loading conditions distress the structural integrity of a structure differently than the static ones. Such actions transfer high rate strains and instant energy waves to the structure, inducing the possibility of imminent collapse and casualties as a direct consequence. In the latest years, considering the dramatic increase of terrorist threats and global warming, the structural safety criteria imply more than ever the need to withstand this kind of loading (e.g., missiles and blast, projectiles, strong winds, tornados and earthquakes in addition to the static ones. The aim of this paper is to provide a general overview with regard to impact loading in terms of defining the phenomenon from physical and mechanical perspective, its complex local or global effect on the targeted structure, relevant material characteristics, main research approaches, namely theoretical studies and experimental procedures developed for improving the predictability of the dynamic loads and their effects. New directions in developing superior cementitious composites, with better characteristics in terms of dynamic loading performance are also emphasized.

  12. Access to general health care services by a New Zealand population with serious mental illness.

    Directory of Open Access Journals (Sweden)

    Wheeler A

    2014-03-01

    Full Text Available INTRODUCTION: Literature suggests that good quality health care access can have a positive impact on the health of people with serious mental illness (SMI, but literature relating to patterns of access by this group is equivocal. AIM: This study was designed to explore health care access patterns in a group of people with SMI and to compare them with a general New Zealand population group, in order for health providers to understand how they might contribute to positive health outcomes for this group. METHODS: The study surveyed 404 mental health consumers aged 18-65 years receiving care from one district health board in Auckland about their patterns of health care access. Results were compared with those from the New Zealand Health Survey of the general population. RESULTS: Findings suggest that the SMI consumer respondents had poorer physical health than the general population respondents, accessed health care services in more complex ways and were more particular about who they accessed for their care than the general population respondents. There was some concern from SMI consumers around discrimination from health care providers. The study also suggested that some proactive management with SMI consumers for conditions such as metabolic syndrome was occurring within the health care community. DISCUSSION: The first point of access for SMI consumers with general health problems is not always the family general practitioner and so other health professionals may sometimes need to consider the mental and physical health of such consumers in a wider context than their own specialism.

  13. Toward Accessing Spatial Structure from Building Information Models

    Science.gov (United States)

    Schultz, C.; Bhatt, M.

    2011-08-01

    Data about building designs and layouts is becoming increasingly more readily available. In the near future, service personal (such as maintenance staff or emergency rescue workers) arriving at a building site will have immediate real-time access to enormous amounts of data relating to structural properties, utilities, materials, temperature, and so on. The critical problem for users is the taxing and error prone task of interpreting such a large body of facts in order to extract salient information. This is necessary for comprehending a situation and deciding on a plan of action, and is a particularly serious issue in time-critical and safety-critical activities such as firefighting. Current unifying building models such as the Industry Foundation Classes (IFC), while being comprehensive, do not directly provide data structures that focus on spatial reasoning and spatial modalities that are required for high-level analytical tasks. The aim of the research presented in this paper is to provide computational tools for higher level querying and reasoning that shift the cognitive burden of dealing with enormous amounts of data away from the user. The user can then spend more energy and time in planning and decision making in order to accomplish the tasks at hand. We present an overview of our framework that provides users with an enhanced model of "built-up space". In order to test our approach using realistic design data (in terms of both scale and the nature of the building models) we describe how our system interfaces with IFC, and we conduct timing experiments to determine the practicality of our approach. We discuss general computational approaches for deriving higher-level spatial modalities by focusing on the example of route graphs. Finally, we present a firefighting scenario with alternative route graphs to motivate the application of our framework.

  14. The Use of an Improved Access Structure in Dictionaries*

    African Journals Online (AJOL)

    rbr

    Page 1 ... that a frame structure and an improved use of outer texts can enhance access to the lexicographic data. Different macrostructural ordering procedures are discussed and it is suggested that the lexicographers of ..... ~-landing, maanlanding; ~less, donker(maan), sonder maan; a ~less night, donkermaan, 'n donker ...

  15. Is small beautiful? Financial structure, size and access to finance

    NARCIS (Netherlands)

    Beck, T.H.L.; Demirgüc-Kunt, A.; Singer, D.E.M.

    2013-01-01

    Combining two unique data sets, this paper explores the relationship between financial structure and firms’ access to financial services. Specifically, it considers the importance of three different types of financial institutions: low-end financial institutions, specialized lenders, and banks. Two

  16. Open Access Initiatives in Africa--Structure, Incentives and Disincentives

    Science.gov (United States)

    Nwagwu, Williams E.

    2013-01-01

    Building open access in Africa is imperative not only for African scholars and researchers doing scientific research but also for the expansion of the global science and technology knowledgebase. This paper examines the structure of homegrown initiatives, and observes very low level of awareness prevailing in the higher educational institutions…

  17. Achieving Access to the General Curriculum for Students with Mental Retardation.

    Science.gov (United States)

    Wehmeyer, Michael L.; Lattin, Dana; Agran, Martin

    2001-01-01

    This article reviews requirements in the Individuals with Disabilities Education Act for providing access to the general education curriculum, examines the intent of the language, and proposes a decision-making model to enable Individualized Education Program teams to reach curriculum decisions that provide such access for students with mental…

  18. Designing A General Deep Web Access Approach Based On A Newly Introduced Factor; Harvestability Factor (HF)

    NARCIS (Netherlands)

    Khelghati, Mohammadreza; van Keulen, Maurice; Hiemstra, Djoerd

    2014-01-01

    The growing need of accessing more and more information draws attentions to huge amount of data hidden behind web forms defined as deep web. To make this data accessible, harvesters have a crucial role. Targeting different domains and websites enhances the need to have a general-purpose harvester

  19. A General Attribute and Rule Based Role-Based Access Control Model

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    Growing numbers of users and many access control policies which involve many different resource attributes in service-oriented environments bring various problems in protecting resource. This paper analyzes the relationships of resource attributes to user attributes in all policies, and propose a general attribute and rule based role-based access control(GAR-RBAC) model to meet the security needs. The model can dynamically assign users to roles via rules to meet the need of growing numbers of users. These rules use different attribute expression and permission as a part of authorization constraints, and are defined by analyzing relations of resource attributes to user attributes in many access policies that are defined by the enterprise. The model is a general access control model, and can support many access control policies, and also can be used to wider application for service. The paper also describes how to use the GAR-RBAC model in Web service environments.

  20. Health Benefits for Vocational Rehabilitation Consumers: Comparison of Access Rates with Workers in the General Population

    Science.gov (United States)

    Lustig, Daniel C.; Strauser, David R.

    2010-01-01

    Access to health insurance is one of the critical aspects of securing employment for people with disabilities. This study investigated whether vocational rehabilitation consumers secured employment with an employer who offered health insurance at similar rates to workers in the general population. In general, the results show that vocational…

  1. Post-General Anesthesia Ultrasound-Guided Venous Mapping Increases Autogenous Access Placement Rates.

    Science.gov (United States)

    Png, C Y Maximilian; Korayem, Adam; Finlay, David J

    2018-04-18

    This study investigates the impact of introducing a post-general anesthesia ultrasound mapping (PAUS) on the type of vascular access chosen for hemodialysis in patients without previous accesses. 203 of 297 consecutive patients met inclusion criteria and were reviewed. Within-subjects analysis was performed on patients with both an outpatient ultrasound-guided vein mapping and a PAUS using sign tests and Wilcoxon signed ranked tests. Further, a between-subjects analysis added patients with only the outpatient vein mapping; demographic and comorbidity data were analyzed using t-tests and chi-squared tests. An ordinal logit regression was run for the type of access placed, while a bivariate logit regression was used to compare rates of autogenous access maturation. 165 (81%) patients received both a standard outpatient vein mapping and a PAUS. At the outpatient vein mapping, 130 (79%) patients had suitable veins for an autogenous access while 35 (21%) patients did not have suitable veins for an autogenous access and were planned for a prosthetic access. During PAUS, all 165 (100%) patients were found to have suitable veins for autogenous access formation (P<0.001). When comparing specific autogenous access configurations, Wilcoxon signed rank testing showed significantly more preferable access configurations in the PAUS group compared to the outpatient mapping (P<0.001); Outpatient mapping resulted in 81 (47%) radiocephalic accesses, 10 (6%) radiobasilic accesses, 20 (12%) brachiocephalic accesses, 19 (12%) brachiobasilic accesses and 35 (21%) prosthetic accesses planned, in contrast to 149 (90%) radiocephalic accesses, 3 (2%) radiobasilic accesses, 10 (6%) brachiocephalic accesses, 3 (2%) brachiobasilic accesses and 0 prosthetic accesses when the same patients were analyzed using PAUS. With the analysis expanded to include the 38 (19%) patients with only the outpatient vein mapping (without-PAUS), the Wilcoxon-Mann-Whitney test showed no significant differences

  2. 28 CFR 16.72 - Exemption of Office of the Associate Attorney General System-limited access.

    Science.gov (United States)

    2010-07-01

    ... Attorney General System-limited access. 16.72 Section 16.72 Judicial Administration DEPARTMENT OF JUSTICE....72 Exemption of Office of the Associate Attorney General System—limited access. (a) The following...) General Files System of the Office of the Associate Attorney General (JUSTICE/AAG-001). These exemptions...

  3. Questioning territorial cohesion: (Un)equal access to services of general interest

    Czech Academy of Sciences Publication Activity Database

    Malý, Jiří

    -, August 2016 (2016), s. 1-21 ISSN 1056-8190 Institutional support: RVO:68145535 Keywords : territorial cohesion * services of general interest * accessibility * spatial justice * Czech Republic Subject RIV: DE - Earth Magnetism, Geodesy, Geography Impact factor: 1.272, year: 2016 http://onlinelibrary.wiley.com/doi/10.1111/pirs.12250/full

  4. Nanotube structures, methods of making nanotube structures, and methods of accessing intracellular space

    Science.gov (United States)

    VanDersarl, Jules J.; Xu, Alexander M.; Melosh, Nicholas A.; Tayebi, Noureddine

    2016-02-23

    In accordance with the purpose(s) of the present disclosure, as embodied and broadly described herein, embodiments of the present disclosure, in one aspect, relate to methods of making a structure including nanotubes, a structure including nanotubes, methods of delivering a fluid to a cell, methods of removing a fluid to a cell, methods of accessing intracellular space, and the like.

  5. Generalized Disjunctions in (Infinitary) Structural Consequence Relations

    Czech Academy of Sciences Publication Activity Database

    Cintula, Petr; Noguera, C.

    2012-01-01

    Roč. 18, č. 3 (2012), s. 442-443 ISSN 1079-8986. [Logic Colloquium 2011. 11.07.2011-16.07.2011, Barcelona] R&D Projects: GA MŠk(CZ) 1M0545 Institutional research plan: CEZ:AV0Z10300504 Keywords : Abstract Algebraic Logic * Generalized disjunction * Proof by cases properties * Consequence relations Subject RIV: BA - General Mathematics http://www.math.ucla.edu/~asl/bsl/1803- toc .htm

  6. 28 CFR 16.71 - Exemption of the Office of the Deputy Attorney General System-limited access.

    Science.gov (United States)

    2010-07-01

    ... Attorney General System-limited access. 16.71 Section 16.71 Judicial Administration DEPARTMENT OF JUSTICE....71 Exemption of the Office of the Deputy Attorney General System—limited access. (a) The following... of the Office of the Deputy Attorney General (JUSTICE/DAG-013). (d) In addition, the Drug Enforcement...

  7. Detection of heart disease by open access echocardiography: a retrospective analysis of general practice referrals.

    Science.gov (United States)

    Chambers, John; Kabir, Saleha; Cajeat, Eric

    2014-02-01

    Heart disease is difficult to detect clinically and it has been suggested that echocardiography should be available to all patients with possible cardiac symptoms or signs. To analyse the results of 2 years of open access echocardiography for the frequency of structural heart disease according to request. Retrospective database analysis in a teaching hospital open access echocardiography service. Reports of all open access transthoracic echocardiograms between January 2011 and December 2012 were categorised as normal, having minor abnormalities, or significant abnormalities according to the indication. There were 2343 open access echocardiograms performed and there were significant abnormalities in 29%, predominantly valve disease (n = 304, 13%), LV systolic dysfunction (n = 179, 8%), aortic dilatation (n = 80, 3%), or pulmonary hypertension (n = 91, 4%). If echocardiography had been targeted at a high-risk group, 267 with valve disease would have been detected (compared to 127 with murmur alone) and 139 with LV systolic dysfunction (compared to 91 with suspected heart failure alone). Most GP practices requested fewer than 10 studies, but 6 practices requested over 70 studies. Open access echocardiograms are often abnormal but structural disease may not be suspected from the clinical request. Uptake by individual practices is patchy. A targeted expansion of echocardiography in patients with a high likelihood of disease is therefore likely to increase the detection of clinically important pathology.

  8. Detection of heart disease by open access echocardiography: a retrospective analysis of general practice referrals

    Science.gov (United States)

    Chambers, John; Kabir, Saleha; Cajeat, Eric

    2014-01-01

    Background Heart disease is difficult to detect clinically and it has been suggested that echocardiography should be available to all patients with possible cardiac symptoms or signs. Aim To analyse the results of 2 years of open access echocardiography for the frequency of structural heart disease according to request. Design and setting Retrospective database analysis in a teaching hospital open access echocardiography service. Method Reports of all open access transthoracic echocardiograms between January 2011 and December 2012 were categorised as normal, having minor abnormalities, or significant abnormalities according to the indication. Results There were 2343 open access echocardiograms performed and there were significant abnormalities in 29%, predominantly valve disease (n = 304, 13%), LV systolic dysfunction (n = 179, 8%), aortic dilatation (n = 80, 3%), or pulmonary hypertension (n = 91, 4%). If echocardiography had been targeted at a high-risk group, 267 with valve disease would have been detected (compared to 127 with murmur alone) and 139 with LV systolic dysfunction (compared to 91 with suspected heart failure alone). Most GP practices requested fewer than 10 studies, but 6 practices requested over 70 studies. Conclusion Open access echocardiograms are often abnormal but structural disease may not be suspected from the clinical request. Uptake by individual practices is patchy. A targeted expansion of echocardiography in patients with a high likelihood of disease is therefore likely to increase the detection of clinically important pathology. PMID:24567615

  9. Variation in Direct Access to Tests to Investigate Cancer: A Survey of English General Practitioners.

    Directory of Open Access Journals (Sweden)

    Brian D Nicholson

    Full Text Available The 2015 NICE guidelines for suspected cancer recommend that English General Practitioners have direct access to diagnostic tests to investigate symptoms of cancer that do not meet the criteria for urgent referral. We aimed to identify the proportion of GPs in England with direct access to these tests.We recruited 533 English GPs through a national clinical research network to complete an online survey about direct access to laboratory, radiology, and endoscopy tests in the three months leading up to the release of the 2015 NICE guidance. If they had direct access to a diagnostic test, GPs were asked about the time necessary to arrange a test and receive a report. Results are reported by NHS sub-region and, adjusting for sampling, for England as a whole.Almost all GPs reported direct access to x-ray and laboratory investigations except faecal occult blood testing (54%, 95% CI 49-59% and urine protein electrophoresis (89%, 95% CI 84-92%. Fewer GPs had direct access to CT scans (54%, 95% CI 49-59% or endoscopy (colonoscopy 32%, 95% CI 28-37%; gastroscopy 72%, 95% CI 67-77%. There was significant variation in direct access between NHS regions for the majority of imaging tests-for example, from 20 to 85% to MRI. Apart from x-ray, very few GPs (1-22% could access radiology and endoscopy within the timescales recommended by NICE. The modal request to test time was 2-4 weeks for routine radiology and 4-6 weeks for routine endoscopy with results taking another 1-2 weeks.At the time that the 2015 NICE guideline was released, local investment was required to not only provide direct access but also reduce the interval between request and test and speed up reporting. Further research using our data as a benchmark is now required to identify whether local improvements in direct access have been achieved in response to the NICE targets. If alternative approaches to test access are to be proposed they must be piloted comprehensively and underpinned by robust

  10. Variation in Direct Access to Tests to Investigate Cancer: A Survey of English General Practitioners

    Science.gov (United States)

    Nicholson, Brian D.; Oke, Jason L.; Rose, Peter W.; Mant, David

    2016-01-01

    Background The 2015 NICE guidelines for suspected cancer recommend that English General Practitioners have direct access to diagnostic tests to investigate symptoms of cancer that do not meet the criteria for urgent referral. We aimed to identify the proportion of GPs in England with direct access to these tests. Methods We recruited 533 English GPs through a national clinical research network to complete an online survey about direct access to laboratory, radiology, and endoscopy tests in the three months leading up to the release of the 2015 NICE guidance. If they had direct access to a diagnostic test, GPs were asked about the time necessary to arrange a test and receive a report. Results are reported by NHS sub-region and, adjusting for sampling, for England as a whole. Results Almost all GPs reported direct access to x-ray and laboratory investigations except faecal occult blood testing (54%, 95% CI 49–59%) and urine protein electrophoresis (89%, 95% CI 84–92%). Fewer GPs had direct access to CT scans (54%, 95% CI 49–59%) or endoscopy (colonoscopy 32%, 95% CI 28–37%; gastroscopy 72%, 95% CI 67–77%). There was significant variation in direct access between NHS regions for the majority of imaging tests—for example, from 20 to 85% to MRI. Apart from x-ray, very few GPs (1–22%) could access radiology and endoscopy within the timescales recommended by NICE. The modal request to test time was 2–4 weeks for routine radiology and 4–6 weeks for routine endoscopy with results taking another 1–2 weeks. Conclusion At the time that the 2015 NICE guideline was released, local investment was required to not only provide direct access but also reduce the interval between request and test and speed up reporting. Further research using our data as a benchmark is now required to identify whether local improvements in direct access have been achieved in response to the NICE targets. If alternative approaches to test access are to be proposed they must be

  11. Generalized rough sets hybrid structure and applications

    CERN Document Server

    Mukherjee, Anjan

    2015-01-01

    The book introduces the concept of “generalized interval valued intuitionistic fuzzy soft sets”. It presents the basic properties of these sets and also, investigates an application of generalized interval valued intuitionistic fuzzy soft sets in decision making with respect to interval of degree of preference. The concept of “interval valued intuitionistic fuzzy soft rough sets” is discussed and interval valued intuitionistic fuzzy soft rough set based multi criteria group decision making scheme is presented, which refines the primary evaluation of the whole expert group and enables us to select the optimal object in a most reliable manner. The book also details concept of interval valued intuitionistic fuzzy sets of type 2. It presents the basic properties of these sets. The book also introduces the concept of “interval valued intuitionistic fuzzy soft topological space (IVIFS topological space)” together with intuitionistic fuzzy soft open sets (IVIFS open sets) and intuitionistic fuzzy soft cl...

  12. General notes on ductility in timber structures

    NARCIS (Netherlands)

    Jorissen, A.J.M.; Fragiacomo, M.

    2011-01-01

    The paper discusses the implications of ductility in design of timber structures under static and dynamic loading including earthquakes. Timber is a material inherently brittle in bending and in tension, unless reinforced adequately. However connections between timber members can exhibit significant

  13. Telemental health technology in deaf and general mental-health services: access and use.

    Science.gov (United States)

    Austen, Sally; McGrath, Melissa

    2006-01-01

    Long-distance travel to provide mental health services for deaf people has implications for efficiency, safety, and equality of service. However, uptake of Telemental Health (TMH) has been slow in both deaf and general mental health services. A quantitative study was used to investigate access to TMH and whether staff confidence, experience, or demographics affect TMH use. It was concluded that staff in neither deaf mental health services nor general mental health services had adequate knowledge of or access to TMH. Staff expressed concerns over TMH's appropriateness in their work. Previous use of videoconferencing was assosciated significantly with confidence, but previous use of videophones was not. Neither staff in deaf services nor deaf staff were more experienced with or more confident about videoconferencing, whereas, within deaf services, deaf staff were significantly more confident about videophone use. Training implications are discussed.

  14. Comparable Measures of Accessibility to Public Transport Using the General Transit Feed Specification

    Directory of Open Access Journals (Sweden)

    Jinjoo Bok

    2016-03-01

    Full Text Available Public transport plays a critical role in the sustainability of urban settings. The mass mobility and quality of urban lives can be improved by establishing public transport networks that are accessible to pedestrians within a reasonable walking distance. Accessibility to public transport is characterized by the ease with which inhabitants can reach means of transportation such as buses or metros. By measuring the degree of accessibility to public transport networks using a common data format, a comparative study can be conducted between different cities or metropolitan areas with different public transit systems. The General Transit Feed Specification (GTFS by Google Developers allows this by offering a common format based on text files and sharing the data set voluntarily produced and contributed by the public transit agencies of many participating cities around the world. This paper suggests a method to assess and compare public transit accessibility in different urban areas using the GTFS feed and demographic data. To demonstrate the value of the new method, six examples of metropolitan areas and their public transit accessibility are presented and compared.

  15. A General Theory of Endogenous Market Structures

    OpenAIRE

    Federico Etro; Paolo Bertoletti

    2014-01-01

    We provide a unified approach to imperfect (monopolistic, Bertrand and Cournot) competition equilibria with demand functions derived from symmetric preferences over a large but finite number of goods. The equilibrium markups depend on the Morishima Elasticity of Substitution/Complementarity between goods, and can be derived directly from the utility functions and ranked unambiguously. We characterize the endogenous market structures, their dependence on market size, income and firms’ producti...

  16. Open access, library and publisher competition, and the evolution of general commerce.

    Science.gov (United States)

    Odlyzko, Andrew M

    2015-02-01

    Discussions of the economics of scholarly communication are usually devoted to Open Access, rising journal prices, publisher profits, and boycotts. That ignores what seems a much more important development in this market. Publishers, through the oft-reviled Big Deal packages, are providing much greater and more egalitarian access to the journal literature, an approximation to true Open Access. In the process, they are also marginalizing libraries and obtaining a greater share of the resources going into scholarly communication. This is enabling a continuation of publisher profits as well as of what for decades has been called "unsustainable journal price escalation." It is also inhibiting the spread of Open Access and potentially leading to an oligopoly of publishers controlling distribution through large-scale licensing. The Big Deal practices are worth studying for several general reasons. The degree to which publishers succeed in diminishing the role of libraries may be an indicator of the degree and speed at which universities transform themselves. More importantly, these Big Deals appear to point the way to the future of the whole economy, where progress is characterized by declining privacy, increasing price discrimination, increasing opaqueness in pricing, increasing reliance on low-paid or unpaid work of others for profits, and business models that depend on customer inertia. © The Author(s) 2014.

  17. Modelling of radionuclide transport along the underground access structures of deep geological repositories

    Energy Technology Data Exchange (ETDEWEB)

    Poller, A. [National Cooperative for the Disposal of Radioactive Waste (NAGRA), Wettingen (Switzerland); Smith, P. [SAM Switzerland GmbH, Zuerich (Switzerland); Mayer, G.; Hayek, M. [AF-Consult Switzerland AG, Baden (Switzerland)

    2014-08-15

    system are finally evaluated using biosphere dose conversion factors. The detailed modelling approaches used are to some extent rather simple and stylised. All simplifications clearly lead to an overestimate of releases. The results obtained for the HLW and for the L/ILW repository are generally similar. Quantitative differences arise from the size of the main facility, from the inventory and the properties of the emplaced waste, as well as from the concepts of how radionuclides are released from the different waste forms. The results show that radionuclide release along the access structures of a deep geological repository is extremely low. Radionuclide release occurs predominantly through the host rock. Globally increasing the hydraulic conductivities that are assumed for the tunnel system and the seals (including the excavation damage zone along these underground structures) increases the calculated flows along all access routes, but the increase is found to level off with increasing hydraulic conductivity of seals and excavation damage zones, as flow becomes ultimately controlled by the limited capacity of the host rock to supply water. The dose rate maxima due to releases via the access structures show the same asymptotic behaviour as the flow, and remain low in all cases. The calculated release rates along the access structures are very low for all variants considered and, in particular, far less than the release rates from the host rock. It is thus concluded that the type of main access route to the underground facilities of a deep geological repository with properties as assumed for the present study is not relevant to its post-closure safety. Finally, even for highly unfavourable parameter values for the hydraulic properties of the seals and the associated excavation damage zones, the calculated dose rates remain well below the regulatory protection criterion of 0.1 mSv per year, often by several orders of magnitude. This finding demonstrates the robustness of

  18. Generalized structural equations improve sexual-selection analyses.

    Directory of Open Access Journals (Sweden)

    Sonia Lombardi

    Full Text Available Sexual selection is an intense evolutionary force, which operates through competition for the access to breeding resources. There are many cases where male copulatory success is highly asymmetric, and few males are able to sire most females. Two main hypotheses were proposed to explain this asymmetry: "female choice" and "male dominance". The literature reports contrasting results. This variability may reflect actual differences among studied populations, but it may also be generated by methodological differences and statistical shortcomings in data analysis. A review of the statistical methods used so far in lek studies, shows a prevalence of Linear Models (LM and Generalized Linear Models (GLM which may be affected by problems in inferring cause-effect relationships; multi-collinearity among explanatory variables and erroneous handling of non-normal and non-continuous distributions of the response variable. In lek breeding, selective pressure is maximal, because large numbers of males and females congregate in small arenas. We used a dataset on lekking fallow deer (Dama dama, to contrast the methods and procedures employed so far, and we propose a novel approach based on Generalized Structural Equations Models (GSEMs. GSEMs combine the power and flexibility of both SEM and GLM in a unified modeling framework. We showed that LMs fail to identify several important predictors of male copulatory success and yields very imprecise parameter estimates. Minor variations in data transformation yield wide changes in results and the method appears unreliable. GLMs improved the analysis, but GSEMs provided better results, because the use of latent variables decreases the impact of measurement errors. Using GSEMs, we were able to test contrasting hypotheses and calculate both direct and indirect effects, and we reached a high precision of the estimates, which implies a high predictive ability. In synthesis, we recommend the use of GSEMs in studies on

  19. Generalized Encoding CRDSA: Maximizing Throughput in Enhanced Random Access Schemes for Satellite

    Directory of Open Access Journals (Sweden)

    Manlio Bacco

    2014-12-01

    Full Text Available This work starts from the analysis of the literature about the Random Access protocols with contention resolution, such as Contention Resolution Diversity Slotted Aloha (CRDSA, and introduces a possible enhancement, named Generalized Encoding Contention Resolution Diversity Slotted Aloha (GE-CRDSA. The GE-CRDSA aims at improving the aggregated throughput when the system load is less than 50%, playing on the opportunity of transmitting an optimal combination of information and parity packets frame by frame. This paper shows the improvement in terms of throughput, by performing traffic estimation and adaptive choice of information and parity rates, when a satellite network undergoes a variable traffic load profile.

  20. Accessibility

    DEFF Research Database (Denmark)

    Brooks, Anthony Lewis

    2017-01-01

    This contribution is timely as it addresses accessibility in regards system hardware and software aligned with introduction of the Twenty-First Century Communications and Video Accessibility Act (CVAA) and adjoined game industry waiver that comes into force January 2017. This is an act created...... by the USA Federal Communications Commission (FCC) to increase the access of persons with disabilities to modern communications, and for other purposes. The act impacts advanced communications services and products including text messaging; e-mail; instant messaging; video communications; browsers; game...... platforms; and games software. However, the CVAA has no legal status in the EU. This text succinctly introduces and questions implications, impact, and wider adoption. By presenting the full CVAA and game industry waiver the text targets to motivate discussions and further publications on the subject...

  1. Analysis of Lamellar Structures with Application of Generalized Functions

    Directory of Open Access Journals (Sweden)

    Kipiani Gela

    2016-12-01

    Full Text Available Theory of differential equations in respect of the functional area is based on the basic concepts on generalized functions and splines. There are some basic concepts related to the theory of generalized functions and their properties are considered in relation to the rod systems and lamellar structures. The application of generalized functions gives the possibility to effectively calculate step-variable stiffness lamellar structures. There are also widely applied structures, in that several in which a number of parallel load bearing layers are interconnected by discrete-elastic links. For analysis of system under study, such as design diagrams, there are applied discrete and discrete-continual models.

  2. Generalized fluid impulse functions for oscillating marine structures

    Science.gov (United States)

    Janardhanan, K.; Price, W. G.; Wu, Y.

    1992-03-01

    A selection of generalized impulse response functions is presented for a variety of rigid and flexible marine structures (i.e. mono-hull, SWATH, floating drydock and twin dock, fixed flexible pile). These functions are determined from calculated and experimental frequency-dependent hydrodynamic data, and the characteristics of these data depend on the type of structure considered. This information is reflected in the shape and duration of the generalized impulse response functions which are pre-requisites for a generalized integro-differential mathematical model describing the dynamic behaviour of the structures to seaway excitation.

  3. Scalla: Structured Cluster Architecture for Low Latency Access

    Energy Technology Data Exchange (ETDEWEB)

    Hanushevsky, Andrew; Wang, Daniel L.; /SLAC

    2012-03-20

    Scalla is a distributed low-latency file access system that incorporates novel techniques that minimize latency and maximize scalability over a large distributed system with a distributed namespace. Scalla's techniques have shown to be effective in nearly a decade of service for the high-energy physics community using commodity hardware and interconnects. We describe the two components used in Scalla that are instrumental in its ability to provide low-latency, fault-tolerant name resolution and load distribution, and enable its use as a high-throughput, low-latency communication layer in the Qserv system, the Large Synoptic Survey Telescope's (LSST's) prototype astronomical query system. Scalla arguably exceeded its three main design objectives: low latency, scaling, and recoverability. In retrospect, these objectives were met using a simple but effective design. Low latency was met by uniformly using linear or constant time algorithms in all high-use paths, avoiding locks whenever possible, and using compact data structures to maximize the memory caching efficiency. Scaling was achieved by architecting the system as a 64-ary tree. Nodes can be added easily and as the number of nodes increases, search performance increases at an exponential rate. Recoverability is inherent in that no permanent state information is maintained and whatever state information is needed it can be quickly constructed or reconstructed in real time. This allows dynamic changes in a cluster of servers with little impact on over-all performance or usability. Today, Scalla is being deployed in environments and for uses that were never conceived in 2001. This speaks well for the systems adaptability but the underlying reason is that the system can meet its three fundamental objectives at the same time.

  4. [A totally implantable venous access device. Implantation in general or local anaesthesia? A retrospective cost analysis].

    Science.gov (United States)

    Schuld, J; Richter, S; Moussavian, M R; Kollmar, O; Schilling, M K

    2009-08-01

    Implantation of venous access port systems can be performed in local or general anesthesia. In spite of the increasing rate of interventionally implanted systems, the surgical cut-down represents a safe alternative. Thus, the question arises whether--in context to the increasing health-economic pressure--open implantation in general anesthesia is still a feasible alternative to implantation in local anesthesia regarding OR efficiency and costs. In a retrospective analysis, 993 patients receiving a totally implantable venous access device between 2001 and 2007 were evaluated regarding OR utilization, turnover times, intraoperative data and costs. Implantations in local (LA) and general anesthesia (GA) were compared. GA was performed in 762 cases (76.6 %), LA was performed in 231 patients (23.3 %). Mean operation time was similar in both groups (LA 47.27 +/- 1.40 min vs. GA 45.41 +/- 0.75 min, p = 0.244). Patients receiving local anesthesia had a significantly shorter stay in the OR unit (LA 95.9 +/- 1.78 min vs. GA 105.92 +/- 0.92 min; p cut (LA 39.57 +/- 0.69 min vs. GA 50.46 +/- 0.52 min; p material costs were significantly lower in the LA group compared with the GA group (LA: 400.72 +/- 8.25 euro vs. GA: 482.86 +/- 6.23 euro; p systems in local anesthesia is superior in comparison to the implantation under general anesthesia regarding procedural times in the OR unit and costs. With the same operation duration, but less personnel and material expenditure, implantation in local anesthesia offers a potential economic advantage by permitting faster changing times. Implantation in GA only should be performed at a special request by the patient or in difficult venous conditions. Georg Thieme Verlag Stuttgart.New York.

  5. The Hamiltonian structure of general relativistic perfect fluids

    International Nuclear Information System (INIS)

    Bao, D.; Houston Univ., TX; Marsden, J.; Walton, R.

    1985-01-01

    We show that the evolution equations for a perfect fluid coupled to general relativity in a general lapse and shift, are Hamiltonian relative to a certain Poisson structure. For the fluid variables, a Lie-Poisson structure associated to the dual of a semi-direct product Lie algebra is used, while the bracket for the gravitational variables has the usual canonical symplectic structure. The evolution is governed by a Hamiltonian which is equivalent to that obtained from a canonical analysis. The relationship of our Hamiltonian structure with other approaches in the literature, such as Clebsch potentials, Lagrangian to Eulerian transformations, and its use in clarifying linearization stability, are discussed. (orig.)

  6. Generalized latent variable modeling multilevel, longitudinal, and structural equation models

    CERN Document Server

    Skrondal, Anders; Rabe-Hesketh, Sophia

    2004-01-01

    This book unifies and extends latent variable models, including multilevel or generalized linear mixed models, longitudinal or panel models, item response or factor models, latent class or finite mixture models, and structural equation models.

  7. Insight into nucleon structure from generalized parton distributions

    International Nuclear Information System (INIS)

    J.W. Negele; R.C. Brower; P. Dreher; R. Edwards; G. Fleming; Ph. Hagler; Th. Lippert; A.V.Pochinsky; D.B. Renner; D. Richards; K. Schilling; W. Schroers

    2004-01-01

    The lowest three moments of generalized parton distributions are calculated in full QCD and provide new insight into the behavior of nucleon electromagnetic form factors, the origin of the nucleon spin, and the transverse structure of the nucleon

  8. 28 CFR 16.70 - Exemption of the Office of the Attorney General System-limited access.

    Science.gov (United States)

    2010-07-01

    ....70 Exemption of the Office of the Attorney General System—limited access. (a) The following system of...); and (g): (1) General Files System of the Office of the Attorney General (JUSTICE/OAG-001). These... 28 Judicial Administration 1 2010-07-01 2010-07-01 false Exemption of the Office of the Attorney...

  9. Structural barriers in access to medical marijuana in the USA?a systematic review protocol

    OpenAIRE

    Valencia, Celina I.; Asaolu, Ibitola O.; Ehiri, John E.; Rosales, Cecilia

    2017-01-01

    Background There are 43 state medical marijuana programs in the USA, yet limited evidence is available on the demographic characteristics of the patient population accessing these programs. Moreover, insights into the social and structural barriers that inform patients? success in accessing medical marijuana are limited. A current gap in the scientific literature exists regarding generalizable data on the social, cultural, and structural mechanisms that hinder access to medical marijuana amon...

  10. A qualitative evaluation of general practitioners' perceptions regarding access to medicines in New Zealand.

    Science.gov (United States)

    Babar, Zaheer-Ud-Din; Grover, Piyush; Butler, Rachael; Bye, Lynne; Sheridan, Janie

    2012-01-01

    The objective of this study was to evaluate general practitioners' (GPs) perceptions regarding access to medicines in New Zealand. Qualitative. Primary care. GPs. GPs' views and perceptions. GPs were of the view that the current range of medicines available in New Zealand was reasonable; however, it was acknowledged that there were some drugs that patients were missing out on. When considering the range of subsidised medicines available in New Zealand, some GPs felt that there had been an improvement over recent years. It was highlighted that unexpected funding changes could create financial barriers for some patients and that administrative procedures and other complexities created barriers in receiving a subsidy for restricted medicines. GPs also reported problems with the availability and sole supply of certain medicines and claimed that switching from a branded medicine to its generic counterpart could be disruptive for patients. The research concluded that although there were some issues with the availability of certain drugs, most GPs were satisfied with the broader access to medicines situation in New Zealand. This view is to contrary to the situation presented by the pharmaceutical industry. The issues around sole supply, the use of generic medicines and the administrative barriers regarding funding of medicines could be improved with better systems. The current work provides a solid account of what GPs see as the advantages and disadvantages of the current system and how they balance these demands in practice.

  11. Open access to MRI for general practitioners: 12 years' experience at one institution -- a retrospective analysis.

    Science.gov (United States)

    Gough-Palmer, A L; Burnett, C; Gedroyc, W M

    2009-08-01

    The aim of this study was to evaluate 12 years of general practitioner (GP) use of open access MRI services at a single London teaching hospital. A retrospective analysis of reports from all GP requests for MRI scans between 1994 and 2005 was performed. The date, scanned body part, and requester details from 1798 scans requested by 209 individual GPs over a continuous 12-year period were recorded. All scans were then graded into four categories based on the severity of reported findings from normal to gross abnormality. Over the study period, GP requests as a percentage of the total (MRI) department workload remained low at approximately 2.6%. Spine, knee and brain requests constituted 86% (n = 1546) of requested scans. 48% (n = 868) of scans were reported as normal or minor degenerative changes only. 26% (n = 466) of scans demonstrated serious pathology that was likely to warrant hospital consultant referral. There was a wide range of scans requested per requester, from 1 to 240 over the period, with an average of 8.5 scans per GP. In conclusion, any department wishing to set up open access to MRI services for GPs could cover the majority of requests by offering spine, knee and brain imaging. The percentage of normal report rates for GP requests is comparable with previous studies of outpatient referrals. A large variation in requesting patterns between GPs suggests the need for increased communication between GPs and imaging departments to optimise use of the service.

  12. Generalized Swept Mid-structure for Polygonal Models

    KAUST Repository

    Martin, Tobias; Chen, Guoning; Musuvathy, Suraj; Cohen, Elaine; Hansen, Charles

    2012-01-01

    We introduce a novel mid-structure called the generalized swept mid-structure (GSM) of a closed polygonal shape, and a framework to compute it. The GSM contains both curve and surface elements and has consistent sheet-by-sheet topology, versus triangle-by-triangle topology produced by other mid-structure methods. To obtain this structure, a harmonic function, defined on the volume that is enclosed by the surface, is used to decompose the volume into a set of slices. A technique for computing the 1D mid-structures of these slices is introduced. The mid-structures of adjacent slices are then iteratively matched through a boundary similarity computation and triangulated to form the GSM. This structure respects the topology of the input surface model is a hybrid mid-structure representation. The construction and topology of the GSM allows for local and global simplification, used in further applications such as parameterization, volumetric mesh generation and medical applications.

  13. Generalized Swept Mid-structure for Polygonal Models

    KAUST Repository

    Martin, Tobias

    2012-05-01

    We introduce a novel mid-structure called the generalized swept mid-structure (GSM) of a closed polygonal shape, and a framework to compute it. The GSM contains both curve and surface elements and has consistent sheet-by-sheet topology, versus triangle-by-triangle topology produced by other mid-structure methods. To obtain this structure, a harmonic function, defined on the volume that is enclosed by the surface, is used to decompose the volume into a set of slices. A technique for computing the 1D mid-structures of these slices is introduced. The mid-structures of adjacent slices are then iteratively matched through a boundary similarity computation and triangulated to form the GSM. This structure respects the topology of the input surface model is a hybrid mid-structure representation. The construction and topology of the GSM allows for local and global simplification, used in further applications such as parameterization, volumetric mesh generation and medical applications.

  14. The generalized accessibility and spectral gap of lower hybrid waves in tokamaks

    International Nuclear Information System (INIS)

    Takahashi, Hironori.

    1994-03-01

    The generalized accessibility of lower hybrid waves, primarily in the current drive regime of tokamak plasmas, which may include shifting, either upward or downward, of the parallel refractive index (n parallel ), is investigated, based upon a cold plasma dispersion relation and various geometrical constraint (G.C.) relations imposed on the behavior of n parallel . It is shown that n parallel upshifting can be bounded and insufficient to bridge a large spectral gap to cause wave damping, depending upon whether the G.C. relation allows the oblique resonance to occur. The traditional n parallel upshifting mechanism caused by the pitch angle of magnetic field lines is shown to lead to contradictions with experimental observations. An upshifting mechanism brought about by the density gradient along field lines is proposed, which is not inconsistent with experimental observations, and provides plausible explanations to some unresolved issues of lower hybrid wave theory, including generation of open-quote seed electrons.close-quote

  15. Exploring Quantum Supremacy in Access Structures of Secret Sharing by Coding Theory

    OpenAIRE

    Matsumoto, Ryutaroh

    2018-01-01

    We consider secret sharing schemes with a classical secret and quantum shares. One example of such schemes was recently reported whose access structure cannot be realized by any secret sharing schemes with classical shares. In this paper, we report further quantum secret sharing schemes whose access structures cannot be realized by any classical secret sharing schemes.

  16. Accessibility, Structure and Reactivity of Individual Catalyst Particles Studied by Fluorescence Microscopy

    NARCIS (Netherlands)

    Hendriks, F.C.|info:eu-repo/dai/nl/412642697

    2017-01-01

    This PhD thesis is aimed at using fluorescence microscopy to study accessibility, structure and reactivity of two types of systems. The first part of this thesis is focused on model zeolite crystals. Fundamental insights into the accessibility and internal structure of zeolite powders and crystals

  17. Structural barriers in access to medical marijuana in the USA-a systematic review protocol.

    Science.gov (United States)

    Valencia, Celina I; Asaolu, Ibitola O; Ehiri, John E; Rosales, Cecilia

    2017-08-07

    There are 43 state medical marijuana programs in the USA, yet limited evidence is available on the demographic characteristics of the patient population accessing these programs. Moreover, insights into the social and structural barriers that inform patients' success in accessing medical marijuana are limited. A current gap in the scientific literature exists regarding generalizable data on the social, cultural, and structural mechanisms that hinder access to medical marijuana among qualifying patients. The goal of this systematic review, therefore, is to identify the aforementioned mechanisms that inform disparities in access to medical marijuana in the USA. This scoping review protocol outlines the proposed study design for the systematic review and evaluation of peer-reviewed scientific literature on structural barriers to medical marijuana access. The protocol follows the guidelines set forth by the Preferred Reporting Items for Systematic review and Meta-Analysis Protocols (PRISMA-P) checklist. The overarching goal of this study is to rigorously evaluate the existing peer-reviewed data on access to medical marijuana in the USA. Income, ethnic background, stigma, and physician preferences have been posited as the primary structural barriers influencing medical marijuana patient population demographics in the USA. Identification of structural barriers to accessing medical marijuana provides a framework for future policies and programs. Evidence-based policies and programs for increasing medical marijuana access help minimize the disparity of access among qualifying patients.

  18. Algebraic structure of general electromagnetic fields and energy flow

    International Nuclear Information System (INIS)

    Hacyan, Shahen

    2011-01-01

    Highlights: → Algebraic structure of general electromagnetic fields in stationary spacetime. → Eigenvalues and eigenvectors of the electomagnetic field tensor. → Energy-momentum in terms of eigenvectors and Killing vector. → Explicit form of reference frame with vanishing Poynting vector. → Application of formalism to Bessel beams. - Abstract: The algebraic structures of a general electromagnetic field and its energy-momentum tensor in a stationary space-time are analyzed. The explicit form of the reference frame in which the energy of the field appears at rest is obtained in terms of the eigenvectors of the electromagnetic tensor and the existing Killing vector. The case of a stationary electromagnetic field is also studied and a comparison is made with the standard short-wave approximation. The results can be applied to the general case of a structured light beams, in flat or curved spaces. Bessel beams are worked out as example.

  19. Large-scale structure observables in general relativity

    International Nuclear Information System (INIS)

    Jeong, Donghui; Schmidt, Fabian

    2015-01-01

    We review recent studies that rigorously define several key observables of the large-scale structure of the Universe in a general relativistic context. Specifically, we consider (i) redshift perturbation of cosmic clock events; (ii) distortion of cosmic rulers, including weak lensing shear and magnification; and (iii) observed number density of tracers of the large-scale structure. We provide covariant and gauge-invariant expressions of these observables. Our expressions are given for a linearly perturbed flat Friedmann–Robertson–Walker metric including scalar, vector, and tensor metric perturbations. While we restrict ourselves to linear order in perturbation theory, the approach can be straightforwardly generalized to higher order. (paper)

  20. General quadratic gauge theory: constraint structure, symmetries and physical functions

    Energy Technology Data Exchange (ETDEWEB)

    Gitman, D M [Institute of Physics, University of Sao Paulo (Brazil); Tyutin, I V [Lebedev Physics Institute, Moscow (Russian Federation)

    2005-06-17

    How can we relate the constraint structure and constraint dynamics of the general gauge theory in the Hamiltonian formulation to specific features of the theory in the Lagrangian formulation, especially relate the constraint structure to the gauge transformation structure of the Lagrangian action? How can we construct the general expression for the gauge charge if the constraint structure in the Hamiltonian formulation is known? Whether we can identify the physical functions defined as commuting with first-class constraints in the Hamiltonian formulation and the physical functions defined as gauge invariant functions in the Lagrangian formulation? The aim of the present paper is to consider the general quadratic gauge theory and to answer the above questions for such a theory in terms of strict assertions. To fulfil such a programme, we demonstrate the existence of the so-called superspecial phase-space variables in terms of which the quadratic Hamiltonian action takes a simple canonical form. On the basis of such a representation, we analyse a functional arbitrariness in the solutions of the equations of motion of the quadratic gauge theory and derive the general structure of symmetries by analysing a symmetry equation. We then use these results to identify the two definitions of physical functions and thus prove the Dirac conjecture.

  1. General analytical shakedown solution for structures with kinematic hardening materials

    Science.gov (United States)

    Guo, Baofeng; Zou, Zongyuan; Jin, Miao

    2016-09-01

    The effect of kinematic hardening behavior on the shakedown behaviors of structure has been investigated by performing shakedown analysis for some specific problems. The results obtained only show that the shakedown limit loads of structures with kinematic hardening model are larger than or equal to those with perfectly plastic model of the same initial yield stress. To further investigate the rules governing the different shakedown behaviors of kinematic hardening structures, the extended shakedown theorem for limited kinematic hardening is applied, the shakedown condition is then proposed, and a general analytical solution for the structural shakedown limit load is thus derived. The analytical shakedown limit loads for fully reversed cyclic loading and non-fully reversed cyclic loading are then given based on the general solution. The resulting analytical solution is applied to some specific problems: a hollow specimen subjected to tension and torsion, a flanged pipe subjected to pressure and axial force and a square plate with small central hole subjected to biaxial tension. The results obtained are compared with those in literatures, they are consistent with each other. Based on the resulting general analytical solution, rules governing the general effects of kinematic hardening behavior on the shakedown behavior of structure are clearly.

  2. Intelligent Access to Sequence and Structure Databases (IASSD) - an interface for accessing information from major web databases.

    Science.gov (United States)

    Ganguli, Sayak; Gupta, Manoj Kumar; Basu, Protip; Banik, Rahul; Singh, Pankaj Kumar; Vishal, Vineet; Bera, Abhisek Ranjan; Chakraborty, Hirak Jyoti; Das, Sasti Gopal

    2014-01-01

    With the advent of age of big data and advances in high throughput technology accessing data has become one of the most important step in the entire knowledge discovery process. Most users are not able to decipher the query result that is obtained when non specific keywords or a combination of keywords are used. Intelligent access to sequence and structure databases (IASSD) is a desktop application for windows operating system. It is written in Java and utilizes the web service description language (wsdl) files and Jar files of E-utilities of various databases such as National Centre for Biotechnology Information (NCBI) and Protein Data Bank (PDB). Apart from that IASSD allows the user to view protein structure using a JMOL application which supports conditional editing. The Jar file is freely available through e-mail from the corresponding author.

  3. NEW WEB-BASED ACCESS TO NUCLEAR STRUCTURE DATASETS.

    Energy Technology Data Exchange (ETDEWEB)

    WINCHELL,D.F.

    2004-09-26

    As part of an effort to migrate the National Nuclear Data Center (NNDC) databases to a relational platform, a new web interface has been developed for the dissemination of the nuclear structure datasets stored in the Evaluated Nuclear Structure Data File and Experimental Unevaluated Nuclear Data List.

  4. Generalized structured component analysis a component-based approach to structural equation modeling

    CERN Document Server

    Hwang, Heungsun

    2014-01-01

    Winner of the 2015 Sugiyama Meiko Award (Publication Award) of the Behaviormetric Society of Japan Developed by the authors, generalized structured component analysis is an alternative to two longstanding approaches to structural equation modeling: covariance structure analysis and partial least squares path modeling. Generalized structured component analysis allows researchers to evaluate the adequacy of a model as a whole, compare a model to alternative specifications, and conduct complex analyses in a straightforward manner. Generalized Structured Component Analysis: A Component-Based Approach to Structural Equation Modeling provides a detailed account of this novel statistical methodology and its various extensions. The authors present the theoretical underpinnings of generalized structured component analysis and demonstrate how it can be applied to various empirical examples. The book enables quantitative methodologists, applied researchers, and practitioners to grasp the basic concepts behind this new a...

  5. Structures of generalized 3-circular projections for symmetric norms

    Indian Academy of Sciences (India)

    Generalized bi-circular projection has been studied by many authors (see the subse- quent paragraph and references at the end of this paper). In particular, Botelho [4] and. Botelho and Jamison [5–8] extensively investigated the structures of GBPs for different. Banach spaces whose isometry group has concrete description ...

  6. Generalized belief propagation on tree robust structured region graphs

    NARCIS (Netherlands)

    Gelfand, A.E.; Welling, M.; Murphy, K.; de Freitas, N.

    2012-01-01

    This paper provides some new guidance in the construction of region graphs for Generalized Belief Propagation (GBP). We connect the problem of choosing the outer regions of a LoopStructured Region Graph (SRG) to that of finding a fundamental cycle basis of the corresponding Markov network. We also

  7. Phase space structure of generalized Gaussian cat states

    International Nuclear Information System (INIS)

    Nicacio, Fernando; Maia, Raphael N.P.; Toscano, Fabricio; Vallejos, Raul O.

    2010-01-01

    We analyze generalized Gaussian cat states obtained by superposing arbitrary Gaussian states. The structure of the interference term of the Wigner function is always hyperbolic, surviving the action of a thermal reservoir. We also consider certain superpositions of mixed Gaussian states. An application to semiclassical dynamics is discussed.

  8. Factor structure and psychometric properties of the General Health ...

    African Journals Online (AJOL)

    Purpose: There is little information about the reliability and validity of the 12-item General Health Questionnaire (GHQ-12) in Ghana. This study sought to examine the reliability and factor structure of the GHQ-12 in Ghanaian adolescents. Methods: High school students (N = 770) completed the GHQ-12 and the Adolescent ...

  9. First-line managers' descriptions and reflections regarding their staff's access to empowering structures.

    Science.gov (United States)

    Skytt, Bernice; Hagerman, Heidi; Strömberg, Annika; Engström, Maria

    2015-11-01

    To elucidate first-line managers' descriptions and reflections regarding their staff's access to empowering structures using Kanter's theory of structural empowerment. Good structural conditions within workplaces are essential to employees' wellbeing, and their ability to access empowerment structures is largely dependent on the management. Twenty-eight first-line managers in elderly care were interviewed. Deductive qualitative content analysis was used to analyse data. Managers perceived that staff had varying degrees of access to the empowering structures described in Kanter's theory - and that they possessed formal power in their roles as contact persons and representatives. The descriptions mostly started from the managers' own actions, although some started from the needs of staff members. All managers described their staff's access to the empowering structures in Kanter's theory as important, yet it seemed as though this was not always reflected on and discussed as a strategic issue. Managers could make use of performance and appraisal dialogues to keep up to date on staff's access to empowering structures. Recurrent discussions in the management group based on such current information could promote staff's access to power through empowering structures and make job definitions a strategic issue in the organisation. © 2014 John Wiley & Sons Ltd.

  10. [Self-referrals at Emergency Care Access Points and triage by General Practitioner Cooperatives].

    Science.gov (United States)

    Smits, M; Rutten, M; Schepers, L; Giesen, P

    2017-01-01

    There is a trend for General Practitioner Cooperatives (GPCs) to co-locate with emergency departments (EDs) of hospitals at Emergency Care Access Points (ECAPs), where the GPCs generally conduct triage and treat a large part of self-referrals who would have gone to the ED by themselves in the past. We have examined patient and care characteristics of self-referrals at ECAPs where triage was conducted by GPCs, also to determine the percentage of self-referrals being referred to the ED. Retrospective cross-sectional observational study. Descriptive analyses of routine registration data from self-referrals of five ECAPs (n = 20.451). Patient age, gender, arrival time, urgency, diagnosis and referral were analysed. Of the self-referrals, 57.9% was male and the mean age was 32.7 years. The number of self-referrals per hour was highest during weekends, particularly between 11 a.m. and 5 p.m. On weekdays, there was a peak between 5 and 9 p.m. Self-referrals were mostly assigned a low-urgency grade (35.7% - U4 or U5) or a mid-urgency grade (49% - U3). Almost half of the self-referrals had trauma of the locomotor system (28%) or the skin (27.3%). In total, 23% of the patients was referred to the ED. Self-referred patients at GPCs are typically young, male and have low- to mid-urgency trauma-related problems. Many self-referrals present themselves on weekend days or early weekday evenings. Over three quarters of these patients can be treated by the GPCs, without referral to the ED. This reduces the workload at the ED.

  11. SSR-based genetic diversity and structure of garlic accessions from Brazil.

    Science.gov (United States)

    da Cunha, Camila Pinto; Resende, Francisco Vilela; Zucchi, Maria Imaculada; Pinheiro, José Baldin

    2014-10-01

    Garlic is a spice and a medicinal plant; hence, there is an increasing interest in 'developing' new varieties with different culinary properties or with high content of nutraceutical compounds. Phenotypic traits and dominant molecular markers are predominantly used to evaluate the genetic diversity of garlic clones. However, 24 SSR markers (codominant) specific for garlic are available in the literature, fostering germplasm researches. In this study, we genotyped 130 garlic accessions from Brazil and abroad using 17 polymorphic SSR markers to assess the genetic diversity and structure. This is the first attempt to evaluate a large set of accessions maintained by Brazilian institutions. A high level of redundancy was detected in the collection (50 % of the accessions represented eight haplotypes). However, non-redundant accessions presented high genetic diversity. We detected on average five alleles per locus, Shannon index of 1.2, HO of 0.5, and HE of 0.6. A core collection was set with 17 accessions, covering 100 % of the alleles with minimum redundancy. Overall FST and D values indicate a strong genetic structure within accessions. Two major groups identified by both model-based (Bayesian approach) and hierarchical clustering (UPGMA dendrogram) techniques were coherent with the classification of accessions according to maturity time (growth cycle): early-late and midseason accessions. Assessing genetic diversity and structure of garlic collections is the first step towards an efficient management and conservation of accessions in genebanks, as well as to advance future genetic studies and improvement of garlic worldwide.

  12. DoD Needs to Improve Screening and Access Controls for General Public Tenants Leasing Housing on Military Installations (REDACTED)

    Science.gov (United States)

    2016-04-01

    helps enhance service members’ quality of life by improving the condition of military-owned housing faster and more economically than traditional...DEPARTMENT OF THE ARMY SUBJECT: DoD Needs to Improve Screening and Access Controls for General Public Tenants Leasing Housing on Military...public tenants who leased DoD privatized housing before granting those tenants unescorted access to military installations. In addition, DoD officials

  13. Generalized synchronization and coherent structures in spatially extended systems

    International Nuclear Information System (INIS)

    Basnarkov, Lasko; Duane, Gregory S.; Kocarev, Ljupco

    2014-01-01

    We study the synchronization of a coupled pair of one-dimensional Kuramoto–Sivashinsky systems, with equations augmented by a third-space-derivative term. With two different values of a system parameter, the two systems synchronize in the generalized sense. The phenomenon persists even in the extreme case when one of the equations is missing the extra term. Master–slave synchronization error is small, so the generalized synchronization relationship is useful for predicting the state of the master from that of the slave, or conversely, for controlling the slave. The spatial density of coupling points required to bring about generalized synchronization appears to be related to the wavelength of traveling wave solutions, and more generally to the width of coherent structures in the separate systems

  14. ATLAS, an integrated structural analysis and design system. Volume 4: Random access file catalog

    Science.gov (United States)

    Gray, F. P., Jr. (Editor)

    1979-01-01

    A complete catalog is presented for the random access files used by the ATLAS integrated structural analysis and design system. ATLAS consists of several technical computation modules which output data matrices to corresponding random access file. A description of the matrices written on these files is contained herein.

  15. Information Architecture and the Comic Arts: Knowledge Structure and Access

    Science.gov (United States)

    Farmer, Lesley S. J.

    2015-01-01

    This article explains information architecture, focusing on comic arts' features for representing and structuring knowledge. Then it details information design theory and information behaviors relative to this format, also noting visual literacy. Next , applications of comic arts in education are listed. With this background, several research…

  16. A General Chemistry Experiment Incorporating Synthesis and Structural Determination

    Science.gov (United States)

    van Ryswyk, Hal

    1997-07-01

    An experiment for the general chemistry laboratory is described wherein gas chromatography-mass spectroscopy (GC-MS) and diffuse reflectance infrared Fourier transform spectroscopy (DRIFTS) are used to characterize the products of a series of microscale reactions on vanillin. A single sophisticated instrument can be incorporated into the laboratory given sufficient attention to the use of sampling accessories and software macros. Synthetic experiments coupled with modern instrumental techniques can be used in the general chemistry laboratory to illustrate the concepts of synthesis, structure, bonding, and spectroscopy.

  17. STUDYING THE SECONDARY STRUCTURE OF ACCESSION NUMBER USING CETD MATRIX

    Directory of Open Access Journals (Sweden)

    Anamika Dutta

    2016-10-01

    Full Text Available This paper, we have tried to analyze about the Secondary Structure of nucleotide sequences of rice. The data have been collected from NCBI (National Centre for Biotechnology Information using Nucleotide as data base. All the programs were developed using R programming language using “sequinr” package. Here, we have used CETD matrix method to study the prediction. The conclusions are drawn accordingly.

  18. Access to capital and capital structure of the firm

    Czech Academy of Sciences Publication Activity Database

    Shamshur, Anastasiya

    -, č. 429 (2010), s. 1-36 ISSN 1211-3298 R&D Projects: GA ČR GA402/09/1595; GA MŠk LC542 Grant - others:MŠk(CZ) SVV-2010-261801 Institutional research plan: CEZ:MSM0021620846 Keywords : capital structure * financing decisions * credit constraints * Eastern Europe Subject RIV: AH - Economics http://www.cerge-ei.cz/pdf/wp/Wp429.pdf

  19. A general modeling framework for describing spatially structured population dynamics

    Science.gov (United States)

    Sample, Christine; Fryxell, John; Bieri, Joanna; Federico, Paula; Earl, Julia; Wiederholt, Ruscena; Mattsson, Brady; Flockhart, Tyler; Nicol, Sam; Diffendorfer, James E.; Thogmartin, Wayne E.; Erickson, Richard A.; Norris, D. Ryan

    2017-01-01

    Variation in movement across time and space fundamentally shapes the abundance and distribution of populations. Although a variety of approaches model structured population dynamics, they are limited to specific types of spatially structured populations and lack a unifying framework. Here, we propose a unified network-based framework sufficiently novel in its flexibility to capture a wide variety of spatiotemporal processes including metapopulations and a range of migratory patterns. It can accommodate different kinds of age structures, forms of population growth, dispersal, nomadism and migration, and alternative life-history strategies. Our objective was to link three general elements common to all spatially structured populations (space, time and movement) under a single mathematical framework. To do this, we adopt a network modeling approach. The spatial structure of a population is represented by a weighted and directed network. Each node and each edge has a set of attributes which vary through time. The dynamics of our network-based population is modeled with discrete time steps. Using both theoretical and real-world examples, we show how common elements recur across species with disparate movement strategies and how they can be combined under a unified mathematical framework. We illustrate how metapopulations, various migratory patterns, and nomadism can be represented with this modeling approach. We also apply our network-based framework to four organisms spanning a wide range of life histories, movement patterns, and carrying capacities. General computer code to implement our framework is provided, which can be applied to almost any spatially structured population. This framework contributes to our theoretical understanding of population dynamics and has practical management applications, including understanding the impact of perturbations on population size, distribution, and movement patterns. By working within a common framework, there is less chance

  20. Structured assessment format for evaluating operative reports in general surgery.

    Science.gov (United States)

    Vergis, Ashley; Gillman, Lawrence; Minor, Samuel; Taylor, Mark; Park, Jason

    2008-01-01

    Despite its multifaceted importance, no validated or reliable tools assess the quality of the dictated operative note. This study determined the construct validity, interrater reliability, and internal consistency of a Structured Assessment Format for Evaluating Operative Reports (SAFE-OR) in general surgery. SAFE-OR was developed by using consensus criteria set forth by the Canadian Association of General Surgeons. This instrument includes a structured assessment and a global quality rating scale. Residents divided into novice and experienced groups viewed and dictated a videotaped laparoscopic sigmoid colectomy. Blinded, independent faculty evaluators graded the transcribed reports using SAFE-OR. Twenty-one residents participated in the study. Mean structured assessment scores (out of 44) were significantly lower for novice versus experienced residents (23.3 +/- 5.2 vs 34.1 +/- 6.0, t = .001). Mean global quality scores (out of 45) were similarly lower for novice residents (25.6 +/- 4.7 vs 35.9 +/- 7.6, t = .006). Interclass correlation coefficients were .98 (95% confidence interval, .96-.99) for structured assessment and .93 (95% confidence interval, .83-.97) for global quality scales. Cronbach alpha coefficients for internal consistency were .85 for structured assessment and .96 for global quality assessment scales. SAFE-OR shows significant construct validity, excellent interrater reliability, and high internal consistency. This tool will allow educators to objectively evaluate the quality of trainee operative reports and provide a mechanism for implementing, monitoring, and refining curriculum for dictation skills.

  1. Open access part II: the structure, resources, and implications for nurses.

    Science.gov (United States)

    Nick, Jan

    2011-11-23

    Electronic publishing has changed the landscape for broadcasting scholarly information. Now Open Access is globalizing scholarly work. Open Access facilitates lifelong learning habits; enhances dissemination and distribution of information; impacts the informatics curriculum; supports active learning; and provides areas for nursing informatics research. In the last 10 years the Open Access Movement has formalized into a distinct publishing paradigm. Many free, full-text resources are now available to guide nursing practice. This article describes the Open Access structure, and provides suggestions for using Open Access resources in classroom and practice settings. The nursing community is only beginning to accept and use Open Access. Yet all nurses should be aware of the unique opportunity to obtain free, current, and scholarly information through a variety of avenues and also to incorporate this information into their daily practice. The resources presented in this article can be used to increase nursing knowledge and support evidence-based practice.

  2. A qualitative study of the impact of the implementation of advanced access in primary healthcare on the working lives of general practice staff

    Directory of Open Access Journals (Sweden)

    Offredy Maxine

    2005-09-01

    Full Text Available Abstract Background The North American model of 'advanced access' has been emulated by the National Primary Care Collaborative in the UK as a way of improving patients' access in primary care. The aim of this study was to explore the impact of the implementation of advanced access on the working lives of general practice staff. Methods A qualitative study design, using semi-structured interviews, was conducted with 18 general practice staff: 6 GPs, 6 practice managers and 6 receptionists. Two neighbouring boroughs in southeast England were used as the study sites. NUD*IST computer software assisted in data management to identify concepts, categories and themes of the data. A framework approach was used to analyse the data. Results Whilst practice managers and receptionists saw advanced access as having a positive effect on their working lives, the responses of general practitioners (GPs were more ambivalent. Receptionists reported improvements in their working lives with a change in their role from gatekeepers for appointments to providing access to appointments, fewer confrontations with patients, and greater job satisfaction. Practice managers perceived reductions in work stress from fewer patient complaints, better use of time, and greater flexibility for contingency planning. GPs recognised benefits in terms of improved consultations, but had concerns about the impact on workload and continuity of care. Conclusion AA has improved working conditions for receptionists, converting their perceived role from gatekeeper to access facilitator, and for practice managers as patients were more satisfied. GP responses were more ambivalent, as they experienced both positive and negative effects.

  3. 10 CFR 62.12 - Contents of a request for emergency access: General information.

    Science.gov (United States)

    2010-01-01

    ... EMERGENCY ACCESS TO NON-FEDERAL AND REGIONAL LOW-LEVEL WASTE DISPOSAL FACILITIES Request for a Commission... the person(s) or company(ies) generating the low-level radioactive waste for which the determination...) Certification that the radioactive waste for which emergency access is requested is low-level radioactive waste...

  4. Communication problems between dementia carers and general practitioners: effect on access to community support services.

    Science.gov (United States)

    Bruce, David G; Paley, Glenys A; Underwood, Peter J; Roberts, David; Steed, Duncan

    2002-08-19

    To investigate the circumstances that led general practitioners to refer dementia sufferers and their carers to community support services. Qualitative study using semi-structured interviews, carried out between 1 September 1999 and 30 April 2000. 21 live-in carers of patients with dementia referred for the first time to a Western Australian metropolitan Aged Care Assessment Team, and 19 of their referring general practitioners. Most referrals occurred after the carers had been experiencing carer stress, and were precipitated by crisis situations. Carers failed to discuss their difficulties with the referring GP for a variety of reasons, including the belief that they should cope because it was their duty. The doctors found it difficult to know how the carers were coping or when to intervene, and some carers tended to resist their attempts to help. Time constraints were a significant problem for both groups. Attitudinal barriers in both carers of patients with dementia and GPs, combined with time constraints, often lead to inadequate assessment of carer problems. While it is important that strategies to improve communication between carers and GPs are developed, it would be sensible for GPs to assume that dementia carers are at risk of carer stress and should be encouraged to use community care services.

  5. LOGISTICS MANAGEMENT IN THE GENERAL STRUCTURE OF COMPANY MANAGEMENT

    OpenAIRE

    SERGIU PETROVICI; ALA GUDIMA

    2011-01-01

    The paper is dedicated to the place of logistics management in the general structure of an enterprise. It states some rules to improve the logistic system through development of logistic management as integral system and through a complex approach, development of a market-orientated logistic management with clear short-term and long-term purposes, development of information system in logistics. The course of Logistics Management is taught at the Cooperative-Commercial University of Moldova at...

  6. A General Sparse Tensor Framework for Electronic Structure Theory.

    Science.gov (United States)

    Manzer, Samuel; Epifanovsky, Evgeny; Krylov, Anna I; Head-Gordon, Martin

    2017-03-14

    Linear-scaling algorithms must be developed in order to extend the domain of applicability of electronic structure theory to molecules of any desired size. However, the increasing complexity of modern linear-scaling methods makes code development and maintenance a significant challenge. A major contributor to this difficulty is the lack of robust software abstractions for handling block-sparse tensor operations. We therefore report the development of a highly efficient symbolic block-sparse tensor library in order to provide access to high-level software constructs to treat such problems. Our implementation supports arbitrary multi-dimensional sparsity in all input and output tensors. We avoid cumbersome machine-generated code by implementing all functionality as a high-level symbolic C++ language library and demonstrate that our implementation attains very high performance for linear-scaling sparse tensor contractions.

  7. Exploring barriers to accessing physiotherapy services for stroke patients at Tema general hospital, Ghana.

    Science.gov (United States)

    Nketia-Kyere, Mercy; Aryeetey, Genevieve Cecilia; Nonvignon, Justice; Aikins, Moses

    2017-01-01

    Physiotherapy has been shown to reduce the risk of disability among stroke patients. Poor adherence to physiotherapy can negatively affect outcomes and healthcare cost. However, very little is known about barriers especially to physiotherapy services in Ghana. The objective of this study was to assess the barriers to physiotherapy services for stroke patients at Tema General Hospital (TGH). The individual/personal and health system barriers to physiotherapy services at TGH were determined. A cross-sectional study design was employed. A simple random sampling technique was used to recruit 207 respondents for a face-to-face interview. Interviewer-administered questionnaires were used to collect data on individual/personal barriers of respondents to physiotherapy services and were described using the Likert's scale. Health system barriers were assessed using a self-structured questionnaire which had section under the following heading: human factors, physiotherapy modalities, physical barriers and material/equipment factors. The time spent waiting for physiotherapy and attitude of physiotherapist towards patients; physiotherapy modality such as electrotherapy, exercise therapy and massage therapy among others were some of the indices measured. Respondents' adherence to Medication was assessed with the Morisky 8-item medication adherence questionnaire. Data were entered and analysed using Epi info 7 and STATA 12.0. Associations between the variables were determined using a chi-square test and logistic regression model was used to test the strength of associations between the independent and the dependent variables. The level of statistical significance was set at p  Tema General Hospital.

  8. General relativistic effects in the structure of massive white dwarfs

    Science.gov (United States)

    Carvalho, G. A.; Marinho, R. M.; Malheiro, M.

    2018-04-01

    In this work we investigate the structure of white dwarfs using the Tolman-Oppenheimer-Volkoff equations and compare our results with those obtained from Newtonian equations of gravitation in order to put in evidence the importance of general relativity (GR) for the structure of such stars. We consider in this work for the matter inside white dwarfs two equations of state, frequently found in the literature, namely, the Chandrasekhar and Salpeter equations of state. We find that using Newtonian equilibrium equations, the radii of massive white dwarfs (M>1.3M_{⊙ }) are overestimated in comparison with GR outcomes. For a mass of 1.415M_{⊙ } the white dwarf radius predicted by GR is about 33% smaller than the Newtonian one. Hence, in this case, for the surface gravity the difference between the general relativistic and Newtonian outcomes is about 65%. We depict the general relativistic mass-radius diagrams as M/M_{⊙ }=R/(a+bR+cR^2+dR^3+kR^4), where a, b, c and d are parameters obtained from a fitting procedure of the numerical results and k=(2.08× 10^{-6}R_{⊙ })^{-1}, being R_{⊙ } the radius of the Sun in km. Lastly, we point out that GR plays an important role to determine any physical quantity that depends, simultaneously, on the mass and radius of massive white dwarfs.

  9. Improved measurements of RNA structure conservation with generalized centroid estimators

    Directory of Open Access Journals (Sweden)

    Yohei eOkada

    2011-08-01

    Full Text Available Identification of non-protein-coding RNAs (ncRNAs in genomes is acrucial task for not only molecular cell biology but alsobioinformatics. Secondary structures of ncRNAs are employed as a keyfeature of ncRNA analysis since biological functions of ncRNAs aredeeply related to their secondary structures. Although the minimumfree energy (MFE structure of an RNA sequence is regarded as the moststable structure, MFE alone could not be an appropriate measure foridentifying ncRNAs since the free energy is heavily biased by thenucleotide composition. Therefore, instead of MFE itself, severalalternative measures for identifying ncRNAs have been proposed such asthe structure conservation index (SCI and the base pair distance(BPD, both of which employ MFE structures. However, thesemeasurements are unfortunately not suitable for identifying ncRNAs insome cases including the genome-wide search and incur high falsediscovery rate. In this study, we propose improved measurements basedon SCI and BPD, applying generalized centroid estimators toincorporate the robustness against low quality multiple alignments.Our experiments show that our proposed methods achieve higher accuracythan the original SCI and BPD for not only human-curated structuralalignments but also low quality alignments produced by CLUSTALW. Furthermore, the centroid-based SCI on CLUSTAL W alignments is moreaccurate than or comparable with that of the original SCI onstructural alignments generated with RAF, a high quality structuralaligner, for which two-fold expensive computational time is requiredon average. We conclude that our methods are more suitable forgenome-wide alignments which are of low quality from the point of viewon secondary structures than the original SCI and BPD.

  10. Multigroup Moderation Test in Generalized Structured Component Analysis

    Directory of Open Access Journals (Sweden)

    Angga Dwi Mulyanto

    2016-05-01

    Full Text Available Generalized Structured Component Analysis (GSCA is an alternative method in structural modeling using alternating least squares. GSCA can be used for the complex analysis including multigroup. GSCA can be run with a free software called GeSCA, but in GeSCA there is no multigroup moderation test to compare the effect between groups. In this research we propose to use the T test in PLS for testing moderation Multigroup on GSCA. T test only requires sample size, estimate path coefficient, and standard error of each group that are already available on the output of GeSCA and the formula is simple so the user does not need a long time for analysis.

  11. Optimal control of large space structures via generalized inverse matrix

    Science.gov (United States)

    Nguyen, Charles C.; Fang, Xiaowen

    1987-01-01

    Independent Modal Space Control (IMSC) is a control scheme that decouples the space structure into n independent second-order subsystems according to n controlled modes and controls each mode independently. It is well-known that the IMSC eliminates control and observation spillover caused when the conventional coupled modal control scheme is employed. The independent control of each mode requires that the number of actuators be equal to the number of modelled modes, which is very high for a faithful modeling of large space structures. A control scheme is proposed that allows one to use a reduced number of actuators to control all modeled modes suboptimally. In particular, the method of generalized inverse matrices is employed to implement the actuators such that the eigenvalues of the closed-loop system are as closed as possible to those specified by the optimal IMSC. Computer simulation of the proposed control scheme on a simply supported beam is given.

  12. General statistical data structure for epidemiologic studies of DOE workers

    International Nuclear Information System (INIS)

    Frome, E.L.; Hudson, D.R.

    1981-01-01

    Epidemiologic studies to evaluate the occupational risks associated with employment in the nuclear industry are currently being conducted by the Department of Energy. Data that have potential value in evaluating any long-term health effects of occupational exposure to low levels of radiation are obtained for each individual at a given facility. We propose a general data structure for statistical analysis that is used to define transformations from the data management system into the data analysis system. Statistical methods of interest in epidemiologic studies include contingency table analysis and survival analysis procedures that can be used to evaluate potential associations between occupational radiation exposure and mortality. The purposes of this paper are to discuss (1) the adequacy of this data structure for single- and multiple-facility analysis and (2) the statistical computing problems encountered in dealing with large populations over extended periods of time

  13. Why do patients seek primary medical care in emergency departments? An ethnographic exploration of access to general practice.

    Science.gov (United States)

    MacKichan, Fiona; Brangan, Emer; Wye, Lesley; Checkland, Kath; Lasserson, Daniel; Huntley, Alyson; Morris, Richard; Tammes, Peter; Salisbury, Chris; Purdy, Sarah

    2017-05-04

    To describe how processes of primary care access influence decisions to seek help at the emergency department (ED). Ethnographic case study combining non-participant observation, informal and formal interviewing. Six general practitioner (GP) practices located in three commissioning organisations in England. Reception areas at each practice were observed over the course of a working week (73 hours in total). Practice documents were collected and clinical and non-clinical staff were interviewed (n=19). Patients with recent ED use, or a carer if aged 16 and under, were interviewed (n=29). Past experience of accessing GP care recursively informed patient decisions about where to seek urgent care, and difficulties with access were implicit in patient accounts of ED use. GP practices had complicated, changeable systems for appointments. This made navigating appointment booking difficult for patients and reception staff, and engendered a mistrust of the system. Increasingly, the telephone was the instrument of demand management, but there were unintended consequences for access. Some patient groups, such as those with English as an additional language, were particularly disadvantaged, and the varying patient and staff semantic of words like 'urgent' and 'emergency' was exacerbated during telephone interactions. Poor integration between in-hours and out-of-hours care and patient perceptions of the quality of care accessible at their GP practice also informed ED use. This study provides important insight into the implicit role of primary care access on the use of ED. Discourses around 'inappropriate' patient demand neglect to recognise that decisions about where to seek urgent care are based on experiential knowledge. Simply speeding up access to primary care or increasing its volume is unlikely to alleviate rising ED use. Systems for accessing care need to be transparent, perceptibly fair and appropriate to the needs of diverse patient groups. © Article author(s) (or

  14. Amyloid oligomer structure characterization from simulations: A general method

    Energy Technology Data Exchange (ETDEWEB)

    Nguyen, Phuong H., E-mail: phuong.nguyen@ibpc.fr [Laboratoire de Biochimie Théorique, UPR 9080, CNRS Université Denis Diderot, Sorbonne Paris Cité IBPC, 13 rue Pierre et Marie Curie, 75005 Paris (France); Li, Mai Suan [Institute of Physics, Polish Academy of Sciences, Al. Lotnikow 32/46, 02-668 Warsaw (Poland); Derreumaux, Philippe, E-mail: philippe.derreumaux@ibpc.fr [Laboratoire de Biochimie Théorique, UPR 9080, CNRS Université Denis Diderot, Sorbonne Paris Cité IBPC, 13 rue Pierre et Marie Curie, 75005 Paris (France); Institut Universitaire de France, 103 Bvd Saint-Germain, 75005 Paris (France)

    2014-03-07

    Amyloid oligomers and plaques are composed of multiple chemically identical proteins. Therefore, one of the first fundamental problems in the characterization of structures from simulations is the treatment of the degeneracy, i.e., the permutation of the molecules. Second, the intramolecular and intermolecular degrees of freedom of the various molecules must be taken into account. Currently, the well-known dihedral principal component analysis method only considers the intramolecular degrees of freedom, and other methods employing collective variables can only describe intermolecular degrees of freedom at the global level. With this in mind, we propose a general method that identifies all the structures accurately. The basis idea is that the intramolecular and intermolecular states are described in terms of combinations of single-molecule and double-molecule states, respectively, and the overall structures of oligomers are the product basis of the intramolecular and intermolecular states. This way, the degeneracy is automatically avoided. The method is illustrated on the conformational ensemble of the tetramer of the Alzheimer's peptide Aβ{sub 9−40}, resulting from two atomistic molecular dynamics simulations in explicit solvent, each of 200 ns, starting from two distinct structures.

  15. We Are Lost: Measuring the Accessibility of Signage in Public General Hospitals

    Science.gov (United States)

    Schuster, Michal; Elroy, Irit; Elmakais, Ido

    2017-01-01

    Hospital signage is a critical element in the patients' and visitors understanding of directions, instructions and warnings in the facility. In multilingual environments organizations need to make sure that the information is accessible in the languages of the people who consume their services. As part of a large-scale study that examined the…

  16. Financial Structure and Economic Welfare: Applied General Equilibrium Development Economics.

    Science.gov (United States)

    Townsend, Robert

    2010-09-01

    This review provides a common framework for researchers thinking about the next generation of micro-founded macro models of growth, inequality, and financial deepening, as well as direction for policy makers targeting microfinance programs to alleviate poverty. Topics include treatment of financial structure general equilibrium models: testing for as-if-complete markets or other financial underpinnings; examining dual-sector models with both a perfectly intermediated sector and a sector in financial autarky, as well as a second generation of these models that embeds information problems and other obstacles to trade; designing surveys to capture measures of income, investment/savings, and flow of funds; and aggregating individuals and households to the level of network, village, or national economy. The review concludes with new directions that overcome conceptual and computational limitations.

  17. Financial Structure and Economic Welfare: Applied General Equilibrium Development Economics

    Science.gov (United States)

    Townsend, Robert

    2010-01-01

    This review provides a common framework for researchers thinking about the next generation of micro-founded macro models of growth, inequality, and financial deepening, as well as direction for policy makers targeting microfinance programs to alleviate poverty. Topics include treatment of financial structure general equilibrium models: testing for as-if-complete markets or other financial underpinnings; examining dual-sector models with both a perfectly intermediated sector and a sector in financial autarky, as well as a second generation of these models that embeds information problems and other obstacles to trade; designing surveys to capture measures of income, investment/savings, and flow of funds; and aggregating individuals and households to the level of network, village, or national economy. The review concludes with new directions that overcome conceptual and computational limitations. PMID:21037939

  18. Access all areas? An area-level analysis of accessibility to general practice and community pharmacy services in England by urbanity and social deprivation.

    Science.gov (United States)

    Todd, Adam; Copeland, Alison; Husband, Andy; Kasim, Adetayo; Bambra, Clare

    2015-05-08

    (1) To determine the percentage of the population in England that has access to a general practitioner (GP) premises within a 20 min walk (the accessibility); (2) explore the relationship between the walking distance to a GP premises and urbanity and social deprivation and (3) compare accessibility of a GP premises to that of a community pharmacy--and how this may vary by urbanity and social deprivation. This area-level analysis spatial study used postcodes for all GP premises and community pharmacies in England. Each postcode was assigned to a population lookup table and Lower Super Output Area (LSOA). The LSOA was then matched to urbanity (urban, town and fringe, or village, hamlet and isolated dwellings) and deprivation decile (using the Index of Multiple Deprivation score 2010). Living within a 20 min walk of a GP premises. Overall, 84.8% of the population is estimated to live within a 20 min walk of a GP premises: 81.2% in the most affluent areas, 98.2% in the most deprived areas, 94.2% in urban and 19.4% in rural areas. This is consistently lower when compared with the population living within a 20 min walk of a community pharmacy. Our study shows that the vast majority of the population live within a 20 min walk of a GP premises, with higher proportions in the most deprived areas--a positive primary care law. However, more people live within a 20 min walk of a community pharmacy compared with a GP premises, and this potentially has implications for the commissioning of future services from these healthcare providers in England. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

  19. Accessibility and spatial distribution of general practice services in an Australian city by levels of social disadvantage.

    Science.gov (United States)

    Hyndman, J C; Holman, C D

    2001-12-01

    The accessibility and spatial distribution of health services provided by the main source of primary medical care in Australia--the general practice surgery--was investigated by level of social disadvantage of local catchment areas. All 459 general practice surgeries in Perth, an Australian city of 1.2 million residents, were surveyed with a 94% response. Amount of service provision was measured using weekly doctor-hours, available from consulting rooms during opening hours, and associated nurse-hours of service. Access factors were defined as the distance to the nearest surgery, provision of Sunday and evening services, ease of making a same day appointment, bulk-billing, and whether the surgery offered a choice of gender of doctor. There were relatively more surgeries in disadvantaged areas and doctor-hours of service provision were also greater (41.0 h/1,000 most disadvantaged vs. 37.9 h/1000 least disadvantaged). Bulk-billing care, at no direct cost to the patient, was more likely to be provided in most disadvantaged areas compared with least disadvantaged areas (61 vs. 38%). However, populations living in the most disadvantaged areas were less likely to be able to see the local GP at short notice (91 vs. 95%), to have access to a local female GP (56 vs. 62%) or a local service in the evenings (42 vs. 51%). While the overall picture of accessibility was favourable, there was considerable variation in the type of services provided to different socioeconomic groups. Health care planners should investigate the reasons for these differences and advise Government to ensure that access factors affecting publicly funded services are equitably distributed.

  20. Diversity of condensed tannin structures affects rumen in vitro methane production in sainfoin (Onobrychis viciifolia) accessions

    NARCIS (Netherlands)

    Hatew, B.; Hayot Carbonero, C.; Stringano, E.; Sales, L. F.; Smith, L. M J; Mueller-Harvey, I.; Hendriks, W. H.; Pellikaan, W. F.

    2015-01-01

    Sainfoin is a non-bloating temperate forage legume with a moderate-to-high condensed tannin (CT) content. This study investigated whether the diversity of sainfoin accessions in terms of CT structures and contents could be related to rumen in vitro gas and methane (CH4) production and fermentation

  1. Structure of, access to and uncertainty in reasoning and their dependence on content

    NARCIS (Netherlands)

    Vos, Henk; et al Mason, L.

    2003-01-01

    It is known that content has an effect on reasoning. In this paper the influence of the content on the structure of reasoning, the access to it, and the ability to handle uncertainty was studied. The participants were presented with reasoning tasks about the weather and about the oscilloscope in

  2. Phase structure of lattice QCD for general number of flavors

    International Nuclear Information System (INIS)

    Iwasaki, Y.; Kanaya, K.; Yoshie, T.; Kaya, S.; Sakai, S.

    2004-01-01

    We investigate the phase structure of lattice QCD for the general number of flavors in the parameter space of gauge coupling constant and quark mass, employing the one-plaquette gauge action and the standard Wilson quark action. Performing a series of simulations for the number of flavors N F =6-360 with degenerate-mass quarks, we find that when N F ≥7 there is a line of a bulk first order phase transition between the confined phase and a deconfined phase at a finite current quark mass in the strong coupling region and the intermediate coupling region. The massless quark line exists only in the deconfined phase. Based on these numerical results in the strong coupling limit and in the intermediate coupling region, we propose the following phase structure, depending on the number of flavors whose masses are less than Λ d which is the physical scale characterizing the phase transition in the weak coupling region: When N F ≥17, there is only a trivial IR fixed point and therefore the theory in the continuum limit is free. On the other hand, when 16≥N F ≥7, there is a nontrivial IR fixed point and therefore the theory is nontrivial with anomalous dimensions, however, without quark confinement. Theories which satisfy both quark confinement and spontaneous chiral symmetry breaking in the continuum limit exist only for N F ≤6

  3. Generating inferences from knowledge structures based on general automata

    Energy Technology Data Exchange (ETDEWEB)

    Koenig, E C

    1983-01-01

    The author shows that the model for knowledge structures for computers based on general automata accommodates procedures for establishing inferences. Algorithms are presented which generate inferences as output of a computer when its sentence input names appropriate knowledge elements contained in an associated knowledge structure already stored in the memory of the computer. The inferences are found to have either a single graph tuple or more than one graph tuple of associated knowledge. Six algorithms pertain to a single graph tuple and a seventh pertains to more than one graph tuple of associated knowledge. A named term is either the automaton, environment, auxiliary receptor, principal receptor, auxiliary effector, or principal effector. The algorithm pertaining to more than one graph tuple requires that the input sentence names the automaton, transformation response, and environment of one of the tuples of associated knowledge in a sequence of tuples. Interaction with the computer may be either in a conversation or examination mode. The algorithms are illustrated by an example. 13 references.

  4. Cafe Variome: general-purpose software for making genotype-phenotype data discoverable in restricted or open access contexts.

    Science.gov (United States)

    Lancaster, Owen; Beck, Tim; Atlan, David; Swertz, Morris; Thangavelu, Dhiwagaran; Veal, Colin; Dalgleish, Raymond; Brookes, Anthony J

    2015-10-01

    Biomedical data sharing is desirable, but problematic. Data "discovery" approaches-which establish the existence rather than the substance of data-precisely connect data owners with data seekers, and thereby promote data sharing. Cafe Variome (http://www.cafevariome.org) was therefore designed to provide a general-purpose, Web-based, data discovery tool that can be quickly installed by any genotype-phenotype data owner, or network of data owners, to make safe or sensitive content appropriately discoverable. Data fields or content of any type can be accommodated, from simple ID and label fields through to extensive genotype and phenotype details based on ontologies. The system provides a "shop window" in front of data, with main interfaces being a simple search box and a powerful "query-builder" that enable very elaborate queries to be formulated. After a successful search, counts of records are reported grouped by "openAccess" (data may be directly accessed), "linkedAccess" (a source link is provided), and "restrictedAccess" (facilitated data requests and subsequent provision of approved records). An administrator interface provides a wide range of options for system configuration, enabling highly customized single-site or federated networks to be established. Current uses include rare disease data discovery, patient matchmaking, and a Beacon Web service. © 2015 WILEY PERIODICALS, INC.

  5. Recursive algorithm for arrays of generalized Bessel functions: Numerical access to Dirac-Volkov solutions.

    Science.gov (United States)

    Lötstedt, Erik; Jentschura, Ulrich D

    2009-02-01

    In the relativistic and the nonrelativistic theoretical treatment of moderate and high-power laser-matter interaction, the generalized Bessel function occurs naturally when a Schrödinger-Volkov and Dirac-Volkov solution is expanded into plane waves. For the evaluation of cross sections of quantum electrodynamic processes in a linearly polarized laser field, it is often necessary to evaluate large arrays of generalized Bessel functions, of arbitrary index but with fixed arguments. We show that the generalized Bessel function can be evaluated, in a numerically stable way, by utilizing a recurrence relation and a normalization condition only, without having to compute any initial value. We demonstrate the utility of the method by illustrating the quantum-classical correspondence of the Dirac-Volkov solutions via numerical calculations.

  6. Analysis of Coded FHSS Systems with Multiple Access Interference over Generalized Fading Channels

    Directory of Open Access Journals (Sweden)

    Salam A. Zummo

    2009-02-01

    Full Text Available We study the effect of interference on the performance of coded FHSS systems. This is achieved by modeling the physical channel in these systems as a block fading channel. In the derivation of the bit error probability over Nakagami fading channels, we use the exact statistics of the multiple access interference (MAI in FHSS systems. Due to the mathematically intractable expression of the Rician distribution, we use the Gaussian approximation to derive the error probability of coded FHSS over Rician fading channel. The effect of pilot-aided channel estimation is studied for Rician fading channels using the Gaussian approximation. From this, the optimal hopping rate in coded FHSS is approximated. Results show that the performance loss due to interference increases as the hopping rate decreases.

  7. Access to Dental Care for Rural Children: A Survey of Nebraska General Dentists

    Science.gov (United States)

    McFarland, Kimberly K.; Salama, Fouad; Yaseen, Muhammad

    2011-01-01

    Background: Pediatric dentists are too few in number to care for all children. Therefore, the level of pediatric dental services provided by general dentists, especially in rural areas, is crucial to improving the dental health of children. Purpose: The objectives of the study were to establish a baseline in regard to the quantity of pediatric…

  8. A general theory for ball lightning structure and light output

    Science.gov (United States)

    Morrow, R.

    2018-03-01

    A general theory for free-floating ball lightning is presented which unifies the phantom plasma ball theory involving the production of very little light, with theories for ball lightning involving light output produced by burning particles from the soil. The mechanism for the formation of plasma balls is shown to be quite general, producing very similar plasma balls independent of initial ion densities over four orders of magnitude. All that is required is an excess of positive ions in the initial ball of ions. The central plasma density after 1 s is shown to be the reciprocal of the ion neutralization coefficient for all cases, both analytically and computationally. Further, the plasma region has zero electric field in all cases. Surrounding the plasma ball is a sphere of positive ions moving away from the centre via their own space-charge field; this space-charge field, which is the same in all cases near the plasma ball, drives negative ions and negative particles towards the plasma centre. The connection with burning particle theories is the proposition that the burning particles are highly-charged which is very likely after a lightning strike. Burning negatively charged particles would be driven into the plasma ball region and trapped while any positively charged particles would be driven away. The plasma ball structure is shown to last more than 10 s and the ‘burnout time’ for a typical coal particle (as an example) has been measured at 5-10 s this is comparable with the lifetimes observed for ball lightning. The light output from a few hundred particles is estimated to be ~1 W, a typical output for ball lightning. Finally, suggestions are made for the generation of ball lightning in the laboratory.

  9. Strengthening Medicare: Will increasing the bulk-billing rate and supply of general practitioners increase access to Medicare-funded general practitioner services and does rurality matter?

    Science.gov (United States)

    Day, Susan E; Alford, Katrina; Dunt, David; Peacock, Stuart; Gurrin, Lyle; Voaklander, Don

    2005-01-01

    Background Recent increases in the bulk-billing rate have been taken as an indication that the Federal government's Strengthening Medicare initiative, and particularly the bulk-billing incentives, are 'working'. Given the enduring geographic differences in the supply of general practitioners (GPs) it is timely to reconsider the impact that this increase in the provision of 'free care' will have on access to Medicare-funded GP services in rural and urban areas of Australia. Utilisation has been modelled as two different stochastic processes: the decision to consult and the frequency of consultation. Results In the decision to consult model the supply of FFS GPs is a more important predictor of utilisation than the bulk-billing rate. Paradoxically the modelling predicts that ceteris paribus increases in either GP supply or the bulk-billing rate appear to have perverse effects in some areas by decreasing utilisation. In the frequency of consultation model, GP density is not a predictor and increasing the bulk-billing rate will unambiguously increase the frequency of consultation across all areas. In both models, the positive impacts associated with changes in supply and cost are constrained outside the inner metropolitan area by reduced geographic accessibility to Medicare-funded GP services. The modelling also shows that people are more likely to consult a GP in areas of high socioeconomic disadvantage, although socioeconomic status is not a predictor of frequency of consultation. Conclusion Bulk-billing rates and the supply of FFS GPs are important features of the Australian health care system that are, potentially, amenable to policy manipulation. The implications of this research are that government policies designed to achieve similarity in these characteristics across geographic areas will not result in equity of access because they fail to address problems caused by geographic inaccessibility in rural and remote areas. Attempting to increase bulk-billing rates

  10. Ross Works on the Assembly Concept for Construction of Erectable Space Structure (ACCESS) During

    Science.gov (United States)

    1985-01-01

    The crew assigned to the STS-61B mission included Bryan D. O'Conner, pilot; Brewster H. Shaw, commander; Charles D. Walker, payload specialist; mission specialists Jerry L. Ross, Mary L. Cleave, and Sherwood C. Spring; and Rodolpho Neri Vela, payload specialist. Launched aboard the Space Shuttle Atlantis November 28, 1985 at 7:29:00 pm (EST), the STS-61B mission's primary payload included three communications satellites: MORELOS-B (Mexico); AUSSAT-2 (Australia); and SATCOM KU-2 (RCA Americom). Two experiments were conducted to test assembling erectable structures in space: EASE (Experimental Assembly of Structures in Extravehicular Activity), and ACCESS (Assembly Concept for Construction of Erectable Space Structure). In a joint venture between NASA/Langley Research Center in Hampton, Virginia, and the Marshall Space Flight Center (MSFC), EASE and ACCESS were developed and demonstrated at MSFC's Neutral Buoyancy Simulator (NBS). In this STS-61B onboard photo, astronaut Ross works on ACCESS high above the orbiter. The primary objective of these experiments was to test the structural assembly concepts for suitability as the framework for larger space structures and to identify ways to improve the productivity of space construction.

  11. Astronaut Ross Approaches Assembly Concept for Construction of Erectable Space Structure (ACCESS)

    Science.gov (United States)

    1999-01-01

    The crew assigned to the STS-61B mission included Bryan D. O'Conner, pilot; Brewster H. Shaw, commander; Charles D. Walker, payload specialist; mission specialists Jerry L. Ross, Mary L. Cleave, and Sherwood C. Spring; and Rodolpho Neri Vela, payload specialist. Launched aboard the Space Shuttle Atlantis November 28, 1985 at 7:29:00 pm (EST), the STS-61B mission's primary payload included three communications satellites: MORELOS-B (Mexico); AUSSAT-2 (Australia); and SATCOM KU-2 (RCA Americom). Two experiments were conducted to test assembling erectable structures in space: EASE (Experimental Assembly of Structures in Extravehicular Activity), and ACCESS (Assembly Concept for Construction of Erectable Space Structure). In a joint venture between NASA/Langley Research Center in Hampton, Virginia, and the Marshall Space Flight Center (MSFC), EASE and ACCESS were developed and demonstrated at MSFC's Neutral Buoyancy Simulator (NBS). In this STS-61B onboard photo, astronaut Ross, perched on the Manipulator Foot Restraint (MFR) approaches the erected ACCESS. The primary objective of these experiments was to test the structural assembly concepts for suitability as the framework for larger space structures and to identify ways to improve the productivity of space construction.

  12. The Impact of Tariff Structure on Customer Retention, Usage, and Profitability of Access Services

    OpenAIRE

    Raghuram Iyengar; Kamel Jedidi; Skander Essegaier; Peter J. Danaher

    2011-01-01

    Past research in marketing and psychology suggests that pricing structure may influence consumers' perception of value. In the context of two commonly used pricing schemes, pay-per-use and two-part tariff, we evaluate the impact of pricing structure on consumer preferences for access services. To this end, we develop a utility-based model of consumer retention and usage of a new service. A notable feature of the model is its ability to capture the pricing structure effect and measure its impa...

  13. Sum rules across the unpolarized Compton processes involving generalized polarizabilities and moments of nucleon structure functions

    Science.gov (United States)

    Lensky, Vadim; Hagelstein, Franziska; Pascalutsa, Vladimir; Vanderhaeghen, Marc

    2018-04-01

    We derive two new sum rules for the unpolarized doubly virtual Compton scattering process on a nucleon, which establish novel low-Q2 relations involving the nucleon's generalized polarizabilities and moments of the nucleon's unpolarized structure functions F1(x ,Q2) and F2(x ,Q2). These relations facilitate the determination of some structure constants which can only be accessed in off-forward doubly virtual Compton scattering, not experimentally accessible at present. We perform an empirical determination for the proton and compare our results with a next-to-leading-order chiral perturbation theory prediction. We also show how these relations may be useful for a model-independent determination of the low-Q2 subtraction function in the Compton amplitude, which enters the two-photon-exchange contribution to the Lamb shift of (muonic) hydrogen. An explicit calculation of the Δ (1232 )-resonance contribution to the muonic-hydrogen 2 P -2 S Lamb shift yields -1 ±1 μ eV , confirming the previously conjectured smallness of this effect.

  14. The general public's willingness to pay for tax increases to support unrestricted access to an Alzheimer's disease medication.

    Science.gov (United States)

    Oremus, Mark; Tarride, Jean-Eric; Raina, Parminder; Thabane, Lehana; Foster, Gary; Goldsmith, Charlie H; Clayton, Natasha

    2012-11-01

    Alzheimer's disease (AD) is a neurodegenerative disorder highlighted by progressive declines in cognitive and functional abilities. Our objective was to assess the general public's maximum willingness to pay ((M)WTP) for an increase in annual personal income taxes to fund unrestricted access to AD medications. We randomly recruited 500 Canadians nationally and used computer-assisted telephone interviewing to administer a questionnaire. The questionnaire contained four 'efficacy' scenarios describing an AD medication as capable of symptomatically treating cognitive decline or modifying disease progression. The scenarios also described the medication as having no adverse effects or a 30% chance of adverse effects. We randomized participants to order of scenarios and willingness-to-pay bid values; (M)WTP for each scenario was the highest accepted bid for that scenario. We conducted linear regression and bootstrap sensitivity analyses to investigate potential determinants of (M)WTP. Mean (M)WTP was highest for the 'disease modification/no adverse effects' scenario ($Can130.26) and lowest for the 'symptomatic treatment/30% chance of adverse effects' scenario ($Can99.16). Bootstrap analyses indicated none of our potential determinants (e.g. age, sex) were associated with participants' (M)WTP. The general public is willing to pay higher income taxes to fund unrestricted access to AD (especially disease-modifying) medications. Consequently, the public should favour placing new AD medications on public drug plans. As far as we are aware, no other study has elicited the general public's willingness to pay for AD medications.

  15. Generalized Artificial Life Structure for Time-dependent Problems

    Institute of Scientific and Technical Information of China (English)

    TSAU Minhe; KAO Weiwen; CHANG Albert

    2009-01-01

    In recent years, more attention has been paid on artificial life researches. Artificial life(AL) is a research on regulating gene parameters of digital organisms under complicated problematic environments through natural selections and evolutions to achieve the final emergence of intelligence. Most recent studies focused on solving certain real problems by artificial life methods, yet without much address on the AL life basic mechanism. The real problems are often very complicated, and the proposed methods sometimes seem too simple to handle those problems. This study proposed a new approach in AL research, named "generalized artificial life structure(GALS)", in which the traditional "gene bits" in genetic algorithms is first replaced by "gene parameters", which could appear anywhere in GALS. A modeling procedure is taken to normalize the input data, and AL "tissue" is innovated to make AL more complex. GALS is anticipated to contribute significantly to the fitness of AL evolution. The formation of"tissue" begins with some different AL basic cells, and then tissue is produced by the casual selections of one or several of these cells. As a result, the gene parameters, represented by "tissues", could become highly diversified. This diversification should have obvious effects on improving gene fitness. This study took the innovative method of GALS in a stock forecasting problem under a carefully designed manipulating platform. And the researching results verify that the GALS is successful in improving the gene evolution fitness.

  16. Contexts and Control Operations Used in Accessing List-Specific, Generalized, and Semantic Memories

    Science.gov (United States)

    Humphreys, Michael S.; Murray, Krista L.; Maguire, Angela M.

    2009-01-01

    The human ability to focus memory retrieval operations on a particular list, episode or memory structure has not been fully appreciated or documented. In Experiment 1-3, we make it increasingly difficult for participants to switch between a less recent list (multiple study opportunities), and a more recent list (single study opportunity). Task…

  17. SSR and morphological trait based population structure analysis of 130 diverse flax (Linum usitatissimum L.) accessions.

    Science.gov (United States)

    Choudhary, Shashi Bhushan; Sharma, Hariom Kumar; Kumar, Arroju Anil; Maruthi, Rangappa Thimmaiah; Mitra, Jiban; Chowdhury, Isholeena; Singh, Binay Kumar; Karmakar, Pran Gobinda

    2017-02-01

    A total of 130 flax accessions of diverse morphotypes and worldwide origin were assessed for genetic diversity and population structure using 11 morphological traits and microsatellite markers (15 gSSRs and 7 EST-SSRs). Analysis performed after classifying these accessions on the basis of plant height, branching pattern, seed size, Indian/foreign origin into six categories called sub-populations viz. fibre type exotic, fibre type indigenous, intermediate type exotic, intermediate type indigenous, linseed type exotic and linseed type indigenous. The study assessed different diversity indices, AMOVA, population structure and included a principal coordinate analysis based on different marker systems. The highest diversity was exhibited by gSSR markers (SI=0.46; He=0.31; P=85.11). AMOVA based on all markers explained significant difference among fibre type, intermediate type and linseed type populations of flax. In terms of variation explained by different markers, EST-SSR markers (12%) better differentiated flax populations compared to morphological (9%) and gSSR (6%) markers at P=0.01. The maximum Nei's unbiased genetic distance (D=0.11) was observed between fibre type and linseed type exotic sub-populations based on EST-SSR markers. The combined structure analysis by using all markers grouped Indian fibre type accessions (63.4%) in a separate cluster along with the Indian intermediate type (48.7%), whereas Indian accessions (82.16%) of linseed type constituted an independent cluster. These findings were supported by the results of the principal coordinate analysis. Morphological markers employed in the study found complementary with microsatellite based markers in deciphering genetic diversity and population structure of the flax germplasm. Copyright © 2016 Académie des sciences. Published by Elsevier Masson SAS. All rights reserved.

  18. A general access to organogold(iii) complexes by oxidative addition of diazonium salts.

    Science.gov (United States)

    Huang, Long; Rominger, Frank; Rudolph, Matthias; Hashmi, A Stephen K

    2016-05-11

    At room temperature under mild photochemical conditions, namely irradiation with a simple blue light LED, gold(i) chloro complexes of both phosphane and carbene ligands in combination with aryldiazonium salts afford arylgold(iii) complexes. With chelating P,N-ligands cationic six- or five-membered chelate complexes were isolated in the form of salts with weakly coordinating counter anions that were brought in from the diazonium salt. With monodentate P ligands or N-heterocyclic carbene ligands and diazonium chlorides neutral arylgold(iii) dichloro complexes were obtained. The coordination geometry was determined by X-ray crystal structure analyses of representative compounds, a cis arrangement of the aryl and the phosphane ligand at the square planar gold(iii) center is observed.

  19. Black Adolescent Females’ Perceptions of Racial Discrimination When Accessing Reproductive and General Health Care

    Directory of Open Access Journals (Sweden)

    Valerie J. Lewis

    2016-09-01

    Full Text Available Adolescents, like adults, frequently experience discrimination, which can be particularly salient in the context of reproductive health care. We examined urban Black adolescent females’ perceived experiences of racial discrimination during reproductive health care encounters. Structured face-to-face interviews were conducted with female African American patients, from age 13 through 20, who obtained reproductive health care services at a single site. Twenty-four participants were enrolled. All were in or graduated from high school, with a mean age of 16.8 years. These young Black women reported infrequent race-based discrimination in the health care setting; however, many reported commonly experiencing discrimination in other places. An awareness of the discrimination that minority young women experience in non–health care settings can help providers demonstrate cultural humility when addressing such concerns with their patients. With this information, providers can provide anticipatory guidance and the tools necessary to navigate complex social systems.

  20. Generalized Nuclear Data: A New Structure (with Supporting Infrastructure) for Handling Nuclear Data

    International Nuclear Information System (INIS)

    Mattoon, C.M.; Beck, B.R.; Patel, N.R.; Summers, N.C.; Hedstrom, G.W.; Brown, D.A.

    2012-01-01

    The Evaluated Nuclear Data File (ENDF) format was designed in the 1960s to accommodate neutron reaction data to support nuclear engineering applications in power, national security and criticality safety. Over the years, the scope of the format has been extended to handle many other kinds of data including charged particle, decay, atomic, photo-nuclear and thermal neutron scattering. Although ENDF has wide acceptance and support for many data types, its limited support for correlated particle emission, limited numeric precision, and general lack of extensibility mean that the nuclear data community cannot take advantage of many emerging opportunities. More generally, the ENDF format provides an unfriendly environment that makes it difficult for new data evaluators and users to create and access nuclear data. The Cross Section Evaluation Working Group (CSEWG) has begun the design of a new Generalized Nuclear Data (or 'GND') structure, meant to replace older formats with a hierarchy that mirrors the underlying physics, and is aligned with modern coding and database practices. In support of this new structure, Lawrence Livermore National Laboratory (LLNL) has updated its nuclear data/reactions management package Fudge to handle GND structured nuclear data. Fudge provides tools for converting both the latest ENDF format (ENDF-6) and the LLNL Evaluated Nuclear Data Library (ENDL) format to and from GND, as well as for visualizing, modifying and processing (i.e., converting evaluated nuclear data into a form more suitable to transport codes) GND structured nuclear data. GND defines the structure needed for storing nuclear data evaluations and the type of data that needs to be stored. But unlike ENDF and ENDL, GND does not define how the data are to be stored in a file. Currently, Fudge writes the structured GND data to a file using the eXtensible Markup Language (XML), as it is ASCII based and can be viewed with any text editor. XML is a meta-language, meaning that it

  1. Generalized Nuclear Data: A New Structure (with Supporting Infrastructure) for Handling Nuclear Data

    Energy Technology Data Exchange (ETDEWEB)

    Mattoon, C.M. [Lawrence Livermore National Laboratory, 7000 East Avenue, Livermore CA (United States); Beck, B.R.; Patel, N.R.; Summers, N.C.; Hedstrom, G.W. [Lawrence Livermore National Laboratory, 7000 East Avenue, Livermore CA (United States); Brown, D.A. [National Nuclear Data Center, Upton NY (United States)

    2012-12-15

    The Evaluated Nuclear Data File (ENDF) format was designed in the 1960s to accommodate neutron reaction data to support nuclear engineering applications in power, national security and criticality safety. Over the years, the scope of the format has been extended to handle many other kinds of data including charged particle, decay, atomic, photo-nuclear and thermal neutron scattering. Although ENDF has wide acceptance and support for many data types, its limited support for correlated particle emission, limited numeric precision, and general lack of extensibility mean that the nuclear data community cannot take advantage of many emerging opportunities. More generally, the ENDF format provides an unfriendly environment that makes it difficult for new data evaluators and users to create and access nuclear data. The Cross Section Evaluation Working Group (CSEWG) has begun the design of a new Generalized Nuclear Data (or 'GND') structure, meant to replace older formats with a hierarchy that mirrors the underlying physics, and is aligned with modern coding and database practices. In support of this new structure, Lawrence Livermore National Laboratory (LLNL) has updated its nuclear data/reactions management package Fudge to handle GND structured nuclear data. Fudge provides tools for converting both the latest ENDF format (ENDF-6) and the LLNL Evaluated Nuclear Data Library (ENDL) format to and from GND, as well as for visualizing, modifying and processing (i.e., converting evaluated nuclear data into a form more suitable to transport codes) GND structured nuclear data. GND defines the structure needed for storing nuclear data evaluations and the type of data that needs to be stored. But unlike ENDF and ENDL, GND does not define how the data are to be stored in a file. Currently, Fudge writes the structured GND data to a file using the eXtensible Markup Language (XML), as it is ASCII based and can be viewed with any text editor. XML is a meta-language, meaning that it

  2. Network access charges, vertical integration, and property rights structure - experiences from the German electricity markets

    International Nuclear Information System (INIS)

    Growitsch, C.; Wein, T.

    2005-01-01

    After the deregulation of the German electricity markets in 1998, the German government opted for a regulatory regime called negotiated third party access, which would be subject to ex-post control by the federal cartel office. Network access charges for new competitors are based on contractual arrangements between energy producers and industrial consumers. As the electricity networks are incontestable natural monopolies, the local and regional network operators are able to set (monopolistic) charges at their own discretion, restricted only by the possible interference of the federal cartel office (Bundeskartellamt). In this paper we analyze if there is evidence for varying charging behaviour depending on the supplier's economic independence (structure of property rights) or its level of vertical integration. For this purpose, we hypothesise that incorporated and vertically integrated suppliers set different charges than independent utility companies. Multivariate estimations show a relation between network access charges and the network operator's economic independence as well as level of vertical integration: on the low voltage level for an estimated annual consumption of 1700 kW/h, vertically integrated firms set-in accordance with our hypothesis-significantly lower access charges than vertically separated suppliers, whereas incorporated network operators charge significantly higher charges compared to independent suppliers. These results could not have been confirmed for other consumptions or voltage levels. (author)

  3. Seeing with the nano-eye: accessing structure, function, and dynamics of matter on its natural length and time scales

    Science.gov (United States)

    Raschke, Markus

    2015-03-01

    To understand and ultimately control the properties of most functional materials, from molecular soft-matter to quantum materials, requires access to the structure, coupling, and dynamics on the elementary time and length scales that define the microscopic interactions in these materials. To gain the desired nanometer spatial resolution with simultaneous spectroscopic specificity we combine scanning probe microscopy with different optical, including coherent, nonlinear, and ultrafast spectroscopies. The underlying near-field interaction mediated by the atomic-force or scanning tunneling microscope tip provides the desired deep-sub wavelength nano-focusing enabling few-nm spatial resolution. I will introduce our generalization of the approach in terms of the near-field impedance matching to a quantum system based on special optical antenna-tip designs. The resulting enhanced and qualitatively new forms of light-matter interaction enable measurements of quantum dynamics in an interacting environment or to image the electromagnetic local density of states of thermal radiation. Other applications include the inter-molecular coupling and dynamics in soft-matter hetero-structures, surface plasmon interferometry as a probe of electronic structure and dynamics in graphene, and quantum phase transitions in correlated electron materials. These examples highlight the general applicability of the new near-field microscopy approach, complementing emergent X-ray and electron imaging tools, aiming towards the ultimate goal of probing matter on its most elementary spatio-temporal level.

  4. Algebraic structure of a generalized coupled dispersionless system

    International Nuclear Information System (INIS)

    Victor, Kuetche Kamgang; Thomas, Bouetou Bouetou; Kofane, Timoleon Crepin

    2006-01-01

    We study a physical model of the O(3)-invariant coupled integrable dispersionless equations that describes the dynamic of a focused system within the background of a plane gravitational field. The investigation is carried out both numerically and analytically, and realized beneath some assumptions superseding the structure constant with the structure function implemented in Lie algebra and quasigroup theory, respectively. The energy density and topological structures such as loop soliton are examined

  5. Rational Modular RNA Engineering Based on In Vivo Profiling of Structural Accessibility.

    Science.gov (United States)

    Leistra, Abigail N; Amador, Paul; Buvanendiran, Aishwarya; Moon-Walker, Alex; Contreras, Lydia M

    2017-12-15

    Bacterial small RNAs (sRNAs) have been established as powerful parts for controlling gene expression. However, development and application of engineered sRNAs has primarily focused on regulating novel synthetic targets. In this work, we demonstrate a rational modular RNA engineering approach that uses in vivo structural accessibility measurements to tune the regulatory activity of a multisubstrate sRNA for differential control of its native target network. Employing the CsrB global sRNA regulator as a model system, we use published in vivo structural accessibility data to infer the contribution of its local structures (substructures) to function and select a subset for engineering. We then modularly recombine the selected substructures, differentially representing those of presumed high or low functional contribution, to build a library of 21 CsrB variants. Using fluorescent translational reporter assays, we demonstrate that the CsrB variants achieve a 5-fold gradient of control of well-characterized Csr network targets. Interestingly, results suggest that less conserved local structures within long, multisubstrate sRNAs may represent better targets for rational engineering than their well-conserved counterparts. Lastly, mapping the impact of sRNA variants on a signature Csr network phenotype indicates the potential of this approach for tuning the activity of global sRNA regulators in the context of metabolic engineering applications.

  6. Matroidal Structure of Generalized Rough Sets Based on Tolerance Relations

    Directory of Open Access Journals (Sweden)

    Hui Li

    2014-01-01

    of the generalized rough set based on the tolerance relation. The matroid can also induce a new relation. We investigate the connection between the original tolerance relation and the induced relation.

  7. Effect of structure and hydrophobicity of soil on the accessibility of diuron

    Science.gov (United States)

    Chaplain, V.; Défossez, P.; Brault, A.; Breuil, S.; Tessier, D.

    2009-04-01

    Effect of structure and hydropbicity of soil on the accessibility of diuron V. Chaplain1, P. Desfossez2, A. Brault1, S. Breuil1 and D. Tessier1. 1 UR INRA PESSAC, RD 10, Versailles F-78026 2 UMR INRA/URCA FARE, 2 Esplanade Roland Garros, BP 224 F-51686 Reims cedex 2 Corresponding author: chaplain@versailles.inra.fr Retention process plays a major role in the fate and impact of organic contaminants in soils. We studied the global talk of accessibility by measuring the influence of soil hydrophobic properties and soil structure on the retention of diuron. We selected seven plots with pH 3.4 to 8.2 of the long-term experiment of 42 plots in Versailles. Textural properties and composition were similar. The organic content was low. Sorption isotherms were obtained on soil slurries and kinetic measurements of diuron sorption were performed on undisturbed soil samples built up using sieved air-dried soil. The results showed that the Freundlich coefficient kf deduced from isotherm curves decreased as pH increased. For a given density, (i) the Koc coefficient, kf/TOC, was linearly related to the contact angle measured on the clay fraction over a wide range of pH (ii) kinetics slightly increased when pH decreased. On the contrary, when a compact structure was involved, a low initial adsorption rate and low adsorption equilibrium were observed. In this case, the structure in micro-aggregates due to the dispersion of fine particles induced by repeated treatment of soil with NaNO3, was assumed to limit the accessibility of adsorption sites.

  8. A Structure for Population Education: Goals, Generalizations, and Behavioral Objectives.

    Science.gov (United States)

    Lane, Mary Turner; Wileman, Ralph E.

    This book is written to assist anyone who wants to learn about, teach, or plan curricula for population education. A structure is provided that educators can use for first graders or for high school students. Chapter 1 identifies the population phenomenon and the need to study it. Chapter 2 gives the elements of the structure: goals,…

  9. A Scalable Data Access Layer to Manage Structured Heterogeneous Biomedical Data.

    Directory of Open Access Journals (Sweden)

    Giovanni Delussu

    Full Text Available This work presents a scalable data access layer, called PyEHR, designed to support the implementation of data management systems for secondary use of structured heterogeneous biomedical and clinical data. PyEHR adopts the openEHR's formalisms to guarantee the decoupling of data descriptions from implementation details and exploits structure indexing to accelerate searches. Data persistence is guaranteed by a driver layer with a common driver interface. Interfaces for two NoSQL Database Management Systems are already implemented: MongoDB and Elasticsearch. We evaluated the scalability of PyEHR experimentally through two types of tests, called "Constant Load" and "Constant Number of Records", with queries of increasing complexity on synthetic datasets of ten million records each, containing very complex openEHR archetype structures, distributed on up to ten computing nodes.

  10. A Scalable Data Access Layer to Manage Structured Heterogeneous Biomedical Data

    Science.gov (United States)

    Lianas, Luca; Frexia, Francesca; Zanetti, Gianluigi

    2016-01-01

    This work presents a scalable data access layer, called PyEHR, designed to support the implementation of data management systems for secondary use of structured heterogeneous biomedical and clinical data. PyEHR adopts the openEHR’s formalisms to guarantee the decoupling of data descriptions from implementation details and exploits structure indexing to accelerate searches. Data persistence is guaranteed by a driver layer with a common driver interface. Interfaces for two NoSQL Database Management Systems are already implemented: MongoDB and Elasticsearch. We evaluated the scalability of PyEHR experimentally through two types of tests, called “Constant Load” and “Constant Number of Records”, with queries of increasing complexity on synthetic datasets of ten million records each, containing very complex openEHR archetype structures, distributed on up to ten computing nodes. PMID:27936191

  11. Applying 4-regular grid structures in large-scale access networks

    DEFF Research Database (Denmark)

    Pedersen, Jens Myrup; Knudsen, Thomas P.; Patel, Ahmed

    2006-01-01

    4-Regular grid structures have been used in multiprocessor systems for decades due to a number of nice properties with regard to routing, protection, and restoration, together with a straightforward planar layout. These qualities are to an increasing extent demanded also in largescale access...... networks, but concerning protection and restoration these demands have been met only to a limited extent by the commonly used ring and tree structures. To deal with the fact that classical 4-regular grid structures are not directly applicable in such networks, this paper proposes a number of extensions...... concerning restoration, protection, scalability, embeddability, flexibility, and cost. The extensions are presented as a tool case, which can be used for implementing semi-automatic and in the longer term full automatic network planning tools....

  12. A Scalable Data Access Layer to Manage Structured Heterogeneous Biomedical Data.

    Science.gov (United States)

    Delussu, Giovanni; Lianas, Luca; Frexia, Francesca; Zanetti, Gianluigi

    2016-01-01

    This work presents a scalable data access layer, called PyEHR, designed to support the implementation of data management systems for secondary use of structured heterogeneous biomedical and clinical data. PyEHR adopts the openEHR's formalisms to guarantee the decoupling of data descriptions from implementation details and exploits structure indexing to accelerate searches. Data persistence is guaranteed by a driver layer with a common driver interface. Interfaces for two NoSQL Database Management Systems are already implemented: MongoDB and Elasticsearch. We evaluated the scalability of PyEHR experimentally through two types of tests, called "Constant Load" and "Constant Number of Records", with queries of increasing complexity on synthetic datasets of ten million records each, containing very complex openEHR archetype structures, distributed on up to ten computing nodes.

  13. Radical covalent organic frameworks: a general strategy to immobilize open-accessible polyradicals for high-performance capacitive energy storage.

    Science.gov (United States)

    Xu, Fei; Xu, Hong; Chen, Xiong; Wu, Dingcai; Wu, Yang; Liu, Hao; Gu, Cheng; Fu, Ruowen; Jiang, Donglin

    2015-06-01

    Ordered π-columns and open nanochannels found in covalent organic frameworks (COFs) could render them able to store electric energy. However, the synthetic difficulty in achieving redox-active skeletons has thus far restricted their potential for energy storage. A general strategy is presented for converting a conventional COF into an outstanding platform for energy storage through post-synthetic functionalization with organic radicals. The radical frameworks with openly accessible polyradicals immobilized on the pore walls undergo rapid and reversible redox reactions, leading to capacitive energy storage with high capacitance, high-rate kinetics, and robust cycle stability. The results suggest that channel-wall functional engineering with redox-active species will be a facile and versatile strategy to explore COFs for energy storage. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  14. Generalized Extreme Value model with Cyclic Covariate Structure ...

    Indian Academy of Sciences (India)

    48

    enhances the estimation of the return period; however, its application is ...... Cohn T A and Lins H F 2005 Nature's style: Naturally trendy; GEOPHYSICAL ..... Final non-stationary GEV models with covariate structures shortlisted based on.

  15. Shamir secret sharing scheme with dynamic access structure (SSSDAS). Case study on nuclear power plant

    Energy Technology Data Exchange (ETDEWEB)

    Thiyagarajan, P.; Thandra, Prasanth Kumar; Rajan, J.; Satyamurthy, S.A.V. [Indira Gandhi Centre for Atomic Research (IGCAR), Kalpakkam (India). Computer Div.; Aghila, G. [National Institute of Technology, Karaikal (India). Dept. of Computer Science and Engineering

    2015-05-15

    In recent years, due to the sophistication offered by the Internet, strategic organizations like nuclear power plants are linked to the outside world communication through the Internet. The entry of outside world communication into strategic organization (nuclear power plant) increases the hacker's attempts to crack its security and to trace any information which is being sent among the top level officials. Information security system in nuclear power plant is very crucial as even small loophole in the security system will lead to a major disaster. Recent cyber attacks in nuclear power plant provoked information security professionals to look deeply into the information security aspects of strategic organizations (nuclear power plant). In these lines, Shamir secret sharing scheme with dynamic access structure (SSSDAS) is proposed in the paper which provides enhanced security by providing dynamic access structure for each node in different hierarchies. The SSSDAS algorithm can be applied to any strategic organizations with hierarchical structures. In this paper the possible scenarios where SSSDAS algorithm can be applied to nuclear power plant is explained as a case study. The proposed SSSDAS scheme identifies the wrong shares, if any, used for reconstruction of the secret. The SSSDAS scheme also address the three major security parameters namely confidentiality, authentication and integrity.

  16. Shamir secret sharing scheme with dynamic access structure (SSSDAS). Case study on nuclear power plant

    International Nuclear Information System (INIS)

    Thiyagarajan, P.; Thandra, Prasanth Kumar; Rajan, J.; Satyamurthy, S.A.V.; Aghila, G.

    2015-01-01

    In recent years, due to the sophistication offered by the Internet, strategic organizations like nuclear power plants are linked to the outside world communication through the Internet. The entry of outside world communication into strategic organization (nuclear power plant) increases the hacker's attempts to crack its security and to trace any information which is being sent among the top level officials. Information security system in nuclear power plant is very crucial as even small loophole in the security system will lead to a major disaster. Recent cyber attacks in nuclear power plant provoked information security professionals to look deeply into the information security aspects of strategic organizations (nuclear power plant). In these lines, Shamir secret sharing scheme with dynamic access structure (SSSDAS) is proposed in the paper which provides enhanced security by providing dynamic access structure for each node in different hierarchies. The SSSDAS algorithm can be applied to any strategic organizations with hierarchical structures. In this paper the possible scenarios where SSSDAS algorithm can be applied to nuclear power plant is explained as a case study. The proposed SSSDAS scheme identifies the wrong shares, if any, used for reconstruction of the secret. The SSSDAS scheme also address the three major security parameters namely confidentiality, authentication and integrity.

  17. On generally covariant quantum field theory and generalized causal and dynamical structures

    International Nuclear Information System (INIS)

    Bannier, U.

    1988-01-01

    We give an example of a generally covariant quasilocal algebra associated with the massive free field. Maximal, two-sided ideals of this algebra are algebraic representatives of external metric fields. In some sense, this algebra may be regarded as a concrete realization of Ekstein's ideas of presymmetry in quantum field theory. Using ideas from our example and from usual algebraic quantum field theory, we discuss a generalized scheme, in which maximal ideals are viewed as algebraic representatives of dynamical equations or Lagrangians. The considered frame is no quantum gravity, but may lead to further insight into the relation between quantum theory and space-time geometry. (orig.)

  18. Canonical structure and extra mode of generalized unimodular gravity

    Science.gov (United States)

    Bufalo, Rodrigo; Oksanen, Markku

    2018-02-01

    We consider a recently proposed generalization of unimodular gravity, where the lapse function is constrained to be equal to a function of the determinant of the spatial metric f (h ), as a potential origin of a dark fluid with a generally h -dependent equation of state parameter. We establish the Hamiltonian analysis and the canonical path integral for the theory. All the special cases that do not match unimodular gravity involve the violation of general covariance, and consequently the physical content of the theory is changed significantly. Particularly, the case of a constant function f is shown to contain an extra physical degree of freedom in each point of space. Physical consequences of the extra degree of freedom are studied in a linearized theory, where the extra mode is carried by the trace of the metric perturbation. The trace mode does not propagate as a wave, since it satisfies an elliptic partial differential equation in spacetime. Consequently, the trace perturbation is shown to grow exponentially with time, which implies instability. The case of a general f (h ) involves additional second-class constraints, which implies the presence of an extra global degree of freedom that depends only on time (instead of the extra local degree of freedom in the case of a constant f ).

  19. Secure Degrees of Freedom Regions of Multiple Access and Interference Channels: The Polytope Structure

    OpenAIRE

    Xie, Jianwei; Ulukus, Sennur

    2014-01-01

    The sum secure degrees of freedom (s.d.o.f.) of two fundamental multi-user network structures, the K-user Gaussian multiple access (MAC) wiretap channel and the K-user interference channel (IC) with secrecy constraints, have been determined recently as K(K-1)/(K(K-1)+1) [1,2] and K(K-1)/(2K-1) [3,4], respectively. In this paper, we determine the entire s.d.o.f. regions of these two channel models. The converse for the MAC follows from a middle step in the converse of [1,2]. The converse for t...

  20. Prediction of RNA secondary structure using generalized centroid estimators.

    Science.gov (United States)

    Hamada, Michiaki; Kiryu, Hisanori; Sato, Kengo; Mituyama, Toutai; Asai, Kiyoshi

    2009-02-15

    Recent studies have shown that the methods for predicting secondary structures of RNAs on the basis of posterior decoding of the base-pairing probabilities has an advantage with respect to prediction accuracy over the conventionally utilized minimum free energy methods. However, there is room for improvement in the objective functions presented in previous studies, which are maximized in the posterior decoding with respect to the accuracy measures for secondary structures. We propose novel estimators which improve the accuracy of secondary structure prediction of RNAs. The proposed estimators maximize an objective function which is the weighted sum of the expected number of the true positives and that of the true negatives of the base pairs. The proposed estimators are also improved versions of the ones used in previous works, namely CONTRAfold for secondary structure prediction from a single RNA sequence and McCaskill-MEA for common secondary structure prediction from multiple alignments of RNA sequences. We clarify the relations between the proposed estimators and the estimators presented in previous works, and theoretically show that the previous estimators include additional unnecessary terms in the evaluation measures with respect to the accuracy. Furthermore, computational experiments confirm the theoretical analysis by indicating improvement in the empirical accuracy. The proposed estimators represent extensions of the centroid estimators proposed in Ding et al. and Carvalho and Lawrence, and are applicable to a wide variety of problems in bioinformatics. Supporting information and the CentroidFold software are available online at: http://www.ncrna.org/software/centroidfold/.

  1. General enumeration of RNA secondary structures based on new ...

    African Journals Online (AJOL)

    Crick base pairs between AU and GC. Based on the new representation, this paper also computes the number of various types of constrained secondary structures taking the minimum stack length 1 and minimum size m for each bonding loop as ...

  2. Geometrical structure of shock waves in general relativity

    Energy Technology Data Exchange (ETDEWEB)

    Modugno, M [Istituto di Matematica, Universita di Lecce (Italia); Stefani, Gianna [Florence Univ. (Italy)

    1979-01-01

    A systematic and geometrical analysis of shock structures in a Riemannian manifold is developed. The jump, the infinitesimal jump and the covariant derivative jump of a tensor are defined globally. By means of derivation laws induced on the shock hypersurface, physically significant operators are defined. As physical applications, the charged fluid electromagnetic and gravitational interacting fields are considered.

  3. A study of the linear free energy model for DNA structures using the generalized Hamiltonian formalism

    Energy Technology Data Exchange (ETDEWEB)

    Yavari, M., E-mail: yavari@iaukashan.ac.ir [Islamic Azad University, Kashan Branch (Iran, Islamic Republic of)

    2016-06-15

    We generalize the results of Nesterenko [13, 14] and Gogilidze and Surovtsev [15] for DNA structures. Using the generalized Hamiltonian formalism, we investigate solutions of the equilibrium shape equations for the linear free energy model.

  4. Diversity and genetic structure of jenipapo (Genipa americana L. Brazilian accessions

    Directory of Open Access Journals (Sweden)

    Ana Veruska Cruz da Silva

    2014-10-01

    Full Text Available Usually known as jenipapo, Genipa americana L. is a Rubiaceae Brazilian native species. It is an important species in the restoration of Brazilian riparian forests and is one of the most promising fruit trees for sustainable harvesting programs. In this study we provide the first data on the genetic diversity and structure of a Jenipapo Germplasm Bank using inter simple sequence repeat (ISSR markers. We evaluated 160 accessions from wild populations, and the data generated from 12 ISSR primers were used to determine genetic variability via a model-based Bayesian procedure (Structure and molecular variance analysis. In addition, Shannon index, genetic diversity and Jaccard coefficients were estimated. A total of 12 primers were used, which generated 123 polymorphic fragments. Four groups were formed from the analysis of the fragments, and the CR1-2 genotype was isolated, being more divergent than the other genotypes.

  5. A bayesian approach to inferring the genetic population structure of sugarcane accessions from INTA (Argentina

    Directory of Open Access Journals (Sweden)

    Mariana Inés Pocovi

    2015-06-01

    Full Text Available Understanding the population structure and genetic diversity in sugarcane (Saccharum officinarum L. accessions from INTA germplasm bank (Argentina will be of great importance for germplasm collection and breeding improvement as it will identify diverse parental combinations to create segregating progenies with maximum genetic variability for further selection. A Bayesian approach, ordination methods (PCoA, Principal Coordinate Analysis and clustering analysis (UPGMA, Unweighted Pair Group Method with Arithmetic Mean were applied to this purpose. Sixty three INTA sugarcane hybrids were genotyped for 107 Simple Sequence Repeat (SSR and 136 Amplified Fragment Length Polymorphism (AFLP loci. Given the low probability values found with AFLP for individual assignment (4.7%, microsatellites seemed to perform better (54% for STRUCTURE analysis that revealed the germplasm to exist in five optimum groups with partly corresponding to their origin. However clusters shown high degree of admixture, F ST values confirmed the existence of differences among groups. Dissimilarity coefficients ranged from 0.079 to 0.651. PCoA separated sugarcane in groups that did not agree with those identified by STRUCTURE. The clustering including all genotypes neither showed resemblance to populations find by STRUCTURE, but clustering performed considering only individuals displaying a proportional membership > 0.6 in their primary population obtained with STRUCTURE showed close similarities. The Bayesian method indubitably brought more information on cultivar origins than classical PCoA and hierarchical clustering method.

  6. Synchronous machines. General principles and structures; Machines synchrones. Principes generaux et structures

    Energy Technology Data Exchange (ETDEWEB)

    Ben Ahmed, H.; Feld, G.; Multon, B. [Ecole Normale Superieure de Cachan, Lab. SATIE, Systemes et Applications des Technologies de l' Information et de l' Energie, UMR CNRS 8029, 94 (France); Bernard, N. [Institut Universitaire de Saint-Nazaire, Institut de Recherche en Electrotechnique et Electronique de Nantes Atlantique (IREENA), 44 - Nantes (France)

    2005-10-01

    Power generation is mainly performed by synchronous rotating machines which consume about a third of the world primary energy. Electric motors used in industrial applications convert about two thirds of this electricity. Therefore, synchronous machines are present everywhere at different scales, from micro-actuators of few micro-watts to thermo-mechanical production units of more than 1 GW, and represent a large variety of structures which have in common the synchronism between the frequency of the power supply currents and the relative movement of the fixed part with respect to the mobile part. Since several decades, these machines are more and more used as variable speed motors with permanent magnets. The advances in power electronics have contributed to the widening of their use in various applications with a huge range of powers. This article presents the general principle of operation of electromechanical converters of synchronous type: 1 - electromechanical conversion in electromagnetic systems: basic laws and elementary structures (elementary structure, energy conversion cycle, case of a system working in linear magnetic regime), rotating fields structure (magneto-motive force and Ferraris theorem, superficial air gap permeance, air gap magnetic induction, case of a permanent magnet inductor, magnetic energy and electromagnetic torque, conditions for reaching a non-null average torque, application to common cases); 2 - constitution, operation modes and efficiency: constitution and main types of synchronous machines, efficiency - analysis by similarity laws (other expression of the electromagnetic torque, thermal limitation in permanent regime, scale effects, effect of pole pairs number, examples of efficiencies and domains of use), operation modes. (J.S.)

  7. Probabilistic structural analysis using a general purpose finite element program

    Science.gov (United States)

    Riha, D. S.; Millwater, H. R.; Thacker, B. H.

    1992-07-01

    This paper presents an accurate and efficient method to predict the probabilistic response for structural response quantities, such as stress, displacement, natural frequencies, and buckling loads, by combining the capabilities of MSC/NASTRAN, including design sensitivity analysis and fast probability integration. Two probabilistic structural analysis examples have been performed and verified by comparison with Monte Carlo simulation of the analytical solution. The first example consists of a cantilevered plate with several point loads. The second example is a probabilistic buckling analysis of a simply supported composite plate under in-plane loading. The coupling of MSC/NASTRAN and fast probability integration is shown to be orders of magnitude more efficient than Monte Carlo simulation with excellent accuracy.

  8. A generalized AKNS hierarchy and its bi-Hamiltonian structures

    International Nuclear Information System (INIS)

    Xia Tiecheng; You Fucai; Chen Dengyuan

    2005-01-01

    First we construct a new isospectral problem with 8 potentials in the present paper. And then a new Lax pair is presented. By making use of Tu scheme, a class of new soliton hierarchy of equations is derived, which is integrable in the sense of Liouville and possesses bi-Hamiltonian structures. After making some reductions, the well-known AKNS hierarchy and other hierarchies of evolution equations are obtained. Finally, in order to illustrate that soliton hierarchy obtained in the paper possesses bi-Hamiltonian structures exactly, we prove that the linear combination of two-Hamiltonian operators admitted are also a Hamiltonian operator constantly. We point out that two Hamiltonian operators obtained of the system are directly derived from a recurrence relations, not from a recurrence operator

  9. Demand and supply for psychological help in general practice in different European countries: access to primary mental health care in six European countries.

    NARCIS (Netherlands)

    Verhaak, P.F.M.; Brink-Muinen, A. van den; Bensing, J.M.; Gask, L.

    2004-01-01

    The general practitioner is usually the first health care contact for mental problems. The position of a general practitioner may vary between health care systems, depending on the referral system (gatekeepers versus directly accessible specialists), presence of fixed lists and the payment system.

  10. Structural dynamic analysis with generalized damping models analysis

    CERN Document Server

    Adhikari , Sondipon

    2013-01-01

    Since Lord Rayleigh introduced the idea of viscous damping in his classic work ""The Theory of Sound"" in 1877, it has become standard practice to use this approach in dynamics, covering a wide range of applications from aerospace to civil engineering. However, in the majority of practical cases this approach is adopted more for mathematical convenience than for modeling the physics of vibration damping. Over the past decade, extensive research has been undertaken on more general ""non-viscous"" damping models and vibration of non-viscously damped systems. This book, along with a related book

  11. Phase structure of generalized Cross-Neveu models

    International Nuclear Information System (INIS)

    Klimenko, K.G.

    1987-01-01

    A phase structure of models with n spinor multiplets has been considered in the space-time of dimension D=2,3. In the case when n=2 and D=3 there may occur vaccums | +> violating chiral invariance, as well as |-> violating P,T symmetry of the model. At D,n=2 depending on the sign of the constant g 12 there also exist two different vacua. It is shown here, that at sufficiently small g 12 the description of the model with the help of the leading order of 1/N expansion is incorrect (there appear tachyons). The properties of Gross-Neveu model have been dealt with at D=3, n=1 and the temperature and chemical potential not equal to zero

  12. A Generalized Lanczos-QR Technique for Structural Analysis

    DEFF Research Database (Denmark)

    Vissing, S.

    systems with very special properties. Due to the finite discretization the matrices are sparse and a relatively large number of problems also has real and symmetric matrices. The matrix equation for an undamped vibration contains two matrices describing tangent stiffness and mass distributions......Within the field of solid mechanics such as structural dynamics and linearized as well as non-linear stability, the eigenvalue problem plays an important role. In the class of finite element and finite difference discretized problems these engineering problems are characterized by large matrix....... Alternatively, in a stability analysis, tangent stiffness and geometric stiffness matrices are introduced into an eigenvalue problem used to determine possible bifurcation points. The common basis for these types of problems is that the matrix equation describing the problem contains two real, symmetric...

  13. Recognition by symmetry derivatives and the generalized structure tensor.

    Science.gov (United States)

    Bigun, Josef; Bigun, Tomas; Nilsson, Kenneth

    2004-12-01

    We suggest a set of complex differential operators that can be used to produce and filter dense orientation (tensor) fields for feature extraction, matching, and pattern recognition. We present results on the invariance properties of these operators, that we call symmetry derivatives. These show that, in contrast to ordinary derivatives, all orders of symmetry derivatives of Gaussians yield a remarkable invariance: They are obtained by replacing the original differential polynomial with the same polynomial, but using ordinary coordinates x and y corresponding to partial derivatives. Moreover, the symmetry derivatives of Gaussians are closed under the convolution operator and they are invariant to the Fourier transform. The equivalent of the structure tensor, representing and extracting orientations of curve patterns, had previously been shown to hold in harmonic coordinates in a nearly identical manner. As a result, positions, orientations, and certainties of intricate patterns, e.g., spirals, crosses, parabolic shapes, can be modeled by use of symmetry derivatives of Gaussians with greater analytical precision as well as computational efficiency. Since Gaussians and their derivatives are utilized extensively in image processing, the revealed properties have practical consequences for local orientation based feature extraction. The usefulness of these results is demonstrated by two applications: 1) tracking cross markers in long image sequences from vehicle crash tests and 2) alignment of noisy fingerprints.

  14. Generalized added masses computation for fluid structure interaction

    International Nuclear Information System (INIS)

    Lazzeri, L.; Cecconi, S.; Scala, M.

    1983-01-01

    The aim of this paper a description of a method to simulate the dynamic effect of a fluid between two structures by means of an added mass and an added stiffness. The method is based on a potential theory which assumes the fluid is inviscid and incompressible (the case of compressibility is discussed); a solution of the corresponding field equation is given as a superposition of elementary conditions (i.e. applicable to elementary boundary conditions). Consequently the pressure and displacements of the fluid on the boundary are given as a function of the series coefficients; the ''work lost'' (i.e. the work done by the pressures on the difference between actual and estimated displacements) is minimized, in this way the expansion coefficients are related to the displacements on the boundaries. Virtual work procedures are then used to compute added masses. The particular case of a free surface (with gravity effects) is discussed, it is shown how the effect can be modelled by means of an added stiffness term. Some examples relative to vibrations in reservoirs are given and discussed. (orig.)

  15. Genome-scale characterization of RNA tertiary structures and their functional impact by RNA solvent accessibility prediction.

    Science.gov (United States)

    Yang, Yuedong; Li, Xiaomei; Zhao, Huiying; Zhan, Jian; Wang, Jihua; Zhou, Yaoqi

    2017-01-01

    As most RNA structures are elusive to structure determination, obtaining solvent accessible surface areas (ASAs) of nucleotides in an RNA structure is an important first step to characterize potential functional sites and core structural regions. Here, we developed RNAsnap, the first machine-learning method trained on protein-bound RNA structures for solvent accessibility prediction. Built on sequence profiles from multiple sequence alignment (RNAsnap-prof), the method provided robust prediction in fivefold cross-validation and an independent test (Pearson correlation coefficients, r, between predicted and actual ASA values are 0.66 and 0.63, respectively). Application of the method to 6178 mRNAs revealed its positive correlation to mRNA accessibility by dimethyl sulphate (DMS) experimentally measured in vivo (r = 0.37) but not in vitro (r = 0.07), despite the lack of training on mRNAs and the fact that DMS accessibility is only an approximation to solvent accessibility. We further found strong association across coding and noncoding regions between predicted solvent accessibility of the mutation site of a single nucleotide variant (SNV) and the frequency of that variant in the population for 2.2 million SNVs obtained in the 1000 Genomes Project. Moreover, mapping solvent accessibility of RNAs to the human genome indicated that introns, 5' cap of 5' and 3' cap of 3' untranslated regions, are more solvent accessible, consistent with their respective functional roles. These results support conformational selections as the mechanism for the formation of RNA-protein complexes and highlight the utility of genome-scale characterization of RNA tertiary structures by RNAsnap. The server and its stand-alone downloadable version are available at http://sparks-lab.org. © 2016 Yang et al.; Published by Cold Spring Harbor Laboratory Press for the RNA Society.

  16. Measurement of exclusive π(0) electroproduction structure functions and their relationship to transverse generalized parton distributions.

    Science.gov (United States)

    Bedlinskiy, I; Kubarovsky, V; Niccolai, S; Stoler, P; Adhikari, K P; Aghasyan, M; Amaryan, M J; Anghinolfi, M; Avakian, H; Baghdasaryan, H; Ball, J; Baltzell, N A; Battaglieri, M; Bennett, R P; Biselli, A S; Bookwalter, C; Boiarinov, S; Briscoe, W J; Brooks, W K; Burkert, V D; Carman, D S; Celentano, A; Chandavar, S; Charles, G; Contalbrigo, M; Crede, V; D'Angelo, A; Daniel, A; Dashyan, N; De Vita, R; De Sanctis, E; Deur, A; Djalali, C; Doughty, D; Dupre, R; Egiyan, H; El Alaoui, A; El Fassi, L; Elouadrhiri, L; Eugenio, P; Fedotov, G; Fegan, S; Fleming, J A; Forest, T A; Fradi, A; Garçon, M; Gevorgyan, N; Giovanetti, K L; Girod, F X; Gohn, W; Gothe, R W; Graham, L; Griffioen, K A; Guegan, B; Guidal, M; Guo, L; Hafidi, K; Hakobyan, H; Hanretty, C; Heddle, D; Hicks, K; Holtrop, M; Ilieva, Y; Ireland, D G; Ishkhanov, B S; Isupov, E L; Jo, H S; Joo, K; Keller, D; Khandaker, M; Khetarpal, P; Kim, A; Kim, W; Klein, F J; Koirala, S; Kubarovsky, A; Kuhn, S E; Kuleshov, S V; Kvaltine, N D; Livingston, K; Lu, H Y; MacGregor, I J D; Mao, Y; Markov, N; Martinez, D; Mayer, M; McKinnon, B; Meyer, C A; Mineeva, T; Mirazita, M; Mokeev, V; Moutarde, H; Munevar, E; Munoz Camacho, C; Nadel-Turonski, P; Niculescu, G; Niculescu, I; Osipenko, M; Ostrovidov, A I; Pappalardo, L L; Paremuzyan, R; Park, K; Park, S; Pasyuk, E; Anefalos Pereira, S; Phelps, E; Pisano, S; Pogorelko, O; Pozdniakov, S; Price, J W; Procureur, S; Prok, Y; Protopopescu, D; Puckett, A J R; Raue, B A; Ricco, G; Rimal, D; Ripani, M; Rosner, G; Rossi, P; Sabatié, F; Saini, M S; Salgado, C; Saylor, N; Schott, D; Schumacher, R A; Seder, E; Seraydaryan, H; Sharabian, Y G; Smith, G D; Sober, D I; Sokhan, D; Stepanyan, S S; Stepanyan, S; Strauch, S; Taiuti, M; Tang, W; Taylor, C E; Tian, Ye; Tkachenko, S; Ungaro, M; Vineyard, M F; Vlassov, A; Voskanyan, H; Voutier, E; Walford, N K; Watts, D P; Weinstein, L B; Weygand, D P; Wood, M H; Zachariou, N; Zhang, J; Zhao, Z W; Zonta, I

    2012-09-14

    Exclusive π(0) electroproduction at a beam energy of 5.75 GeV has been measured with the Jefferson Lab CLAS spectrometer. Differential cross sections were measured at more than 1800 kinematic values in Q(2), x(B), t, and ϕ(π), in the Q(2) range from 1.0 to 4.6  GeV(2), -t up to 2  GeV(2), and x(B) from 0.1 to 0.58. Structure functions σ(T)+ϵσ(L), σ(TT), and σ(LT) were extracted as functions of t for each of 17 combinations of Q(2) and x(B). The data were compared directly with two handbag-based calculations including both longitudinal and transversity generalized parton distributions (GPDs). Inclusion of only longitudinal GPDs very strongly underestimates σ(T)+ϵσ(L) and fails to account for σ(TT) and σ(LT), while inclusion of transversity GPDs brings the calculations into substantially better agreement with the data. There is very strong sensitivity to the relative contributions of nucleon helicity-flip and helicity nonflip processes. The results confirm that exclusive π(0) electroproduction offers direct experimental access to the transversity GPDs.

  17. Measurement of Exclusive π0 Electroproduction Structure Functions and their Relationship to Transverse Generalized Parton Distributions

    Science.gov (United States)

    Bedlinskiy, I.; Kubarovsky, V.; Niccolai, S.; Stoler, P.; Adhikari, K. P.; Aghasyan, M.; Amaryan, M. J.; Anghinolfi, M.; Avakian, H.; Baghdasaryan, H.; Ball, J.; Baltzell, N. A.; Battaglieri, M.; Bennett, R. P.; Biselli, A. S.; Bookwalter, C.; Boiarinov, S.; Briscoe, W. J.; Brooks, W. K.; Burkert, V. D.; Carman, D. S.; Celentano, A.; Chandavar, S.; Charles, G.; Contalbrigo, M.; Crede, V.; D'Angelo, A.; Daniel, A.; Dashyan, N.; De Vita, R.; De Sanctis, E.; Deur, A.; Djalali, C.; Doughty, D.; Dupre, R.; Egiyan, H.; El Alaoui, A.; El Fassi, L.; Elouadrhiri, L.; Eugenio, P.; Fedotov, G.; Fegan, S.; Fleming, J. A.; Forest, T. A.; Fradi, A.; Garçon, M.; Gevorgyan, N.; Giovanetti, K. L.; Girod, F. X.; Gohn, W.; Gothe, R. W.; Graham, L.; Griffioen, K. A.; Guegan, B.; Guidal, M.; Guo, L.; Hafidi, K.; Hakobyan, H.; Hanretty, C.; Heddle, D.; Hicks, K.; Holtrop, M.; Ilieva, Y.; Ireland, D. G.; Ishkhanov, B. S.; Isupov, E. L.; Jo, H. S.; Joo, K.; Keller, D.; Khandaker, M.; Khetarpal, P.; Kim, A.; Kim, W.; Klein, F. J.; Koirala, S.; Kubarovsky, A.; Kuhn, S. E.; Kuleshov, S. V.; Kvaltine, N. D.; Livingston, K.; Lu, H. Y.; MacGregor, I. J. D.; Mao, Y.; Markov, N.; Martinez, D.; Mayer, M.; McKinnon, B.; Meyer, C. A.; Mineeva, T.; Mirazita, M.; Mokeev, V.; Moutarde, H.; Munevar, E.; Munoz Camacho, C.; Nadel-Turonski, P.; Niculescu, G.; Niculescu, I.; Osipenko, M.; Ostrovidov, A. I.; Pappalardo, L. L.; Paremuzyan, R.; Park, K.; Park, S.; Pasyuk, E.; Anefalos Pereira, S.; Phelps, E.; Pisano, S.; Pogorelko, O.; Pozdniakov, S.; Price, J. W.; Procureur, S.; Prok, Y.; Protopopescu, D.; Puckett, A. J. R.; Raue, B. A.; Ricco, G.; Rimal, D.; Ripani, M.; Rosner, G.; Rossi, P.; Sabatié, F.; Saini, M. S.; Salgado, C.; Saylor, N.; Schott, D.; Schumacher, R. A.; Seder, E.; Seraydaryan, H.; Sharabian, Y. G.; Smith, G. D.; Sober, D. I.; Sokhan, D.; Stepanyan, S. S.; Stepanyan, S.; Strauch, S.; Taiuti, M.; Tang, W.; Taylor, C. E.; Tian, Ye; Tkachenko, S.; Ungaro, M.; Vineyard, M. F.; Vlassov, A.; Voskanyan, H.; Voutier, E.; Walford, N. K.; Watts, D. P.; Weinstein, L. B.; Weygand, D. P.; Wood, M. H.; Zachariou, N.; Zhang, J.; Zhao, Z. W.; Zonta, I.

    2012-09-01

    Exclusive π0 electroproduction at a beam energy of 5.75 GeV has been measured with the Jefferson Lab CLAS spectrometer. Differential cross sections were measured at more than 1800 kinematic values in Q2, xB, t, and ϕπ, in the Q2 range from 1.0 to 4.6GeV2, -t up to 2GeV2, and xB from 0.1 to 0.58. Structure functions σT+ɛσL, σTT, and σLT were extracted as functions of t for each of 17 combinations of Q2 and xB. The data were compared directly with two handbag-based calculations including both longitudinal and transversity generalized parton distributions (GPDs). Inclusion of only longitudinal GPDs very strongly underestimates σT+ɛσL and fails to account for σTT and σLT, while inclusion of transversity GPDs brings the calculations into substantially better agreement with the data. There is very strong sensitivity to the relative contributions of nucleon helicity-flip and helicity nonflip processes. The results confirm that exclusive π0 electroproduction offers direct experimental access to the transversity GPDs.

  18. New Integrable Couplings of Generalized Kaup-Newell Hierarchy and Its Hamiltonian Structures

    International Nuclear Information System (INIS)

    Xia Tiecheng; Zhang Gailian; Fan Engui

    2011-01-01

    A new isospectral problem is firstly presented, then we derive integrable system of soliton hierarchy. Also we obtain new integrable couplings of the generalized Kaup-Newell soliton equations hierarchy and its Hamiltonian structures by using Tu scheme and the quadratic-form identity. The method can be generalized to other soliton hierarchy. (general)

  19. Developing an EarthCube Governance Structure for Big Data Preservation and Access

    Science.gov (United States)

    Leetaru, H. E.; Leetaru, K. H.

    2012-12-01

    The underlying vision of the NSF EarthCube initiative is of an enduring resource serving the needs of the earth sciences for today and the future. We must therefore view this effort through the lens of what the earth sciences will need tomorrow and on how the underlying processes of data compilation, preservation, and access interplay with the scientific processes within the communities EarthCube will serve. Key issues that must be incorporated into the EarthCube governance structure include authentication, retrieval, and unintended use cases, the emerging role of whole-corpus data mining, and how inventory, citation, and archive practices will impact the ability of scientists to use EarthCube's collections into the future. According to the National Academies, the US federal government spends over $140 billion dollars a year in support of the nation's research base. Yet, a critical issue confronting all of the major scientific disciplines in building upon this investment is the lack of processes that guide how data are preserved for the long-term, ensuring that studies can be replicated and that experimental data remains accessible as new analytic methods become available or theories evolve. As datasets are used years or even decades after their creation, far richer metadata is needed to describe the underlying simulation, smoothing algorithms or bounding parameters of the data collection process. This is even truer as data are increasingly used outside their intended disciplines, as geoscience researchers apply algorithms from one discipline to datasets from another, where their analytical techniques may make extensive assumptions about the data. As science becomes increasingly interdisciplinary and emerging computational approaches begin applying whole-corpus methodologies and blending multiple archives together, we are facing new data access modalities distinct from the needs of the past, drawing into focus the question of centralized versus distributed

  20. Structure Determination of Unknown Organic Liquids Using NMR and IR Spectroscopy: A General Chemistry Laboratory

    Science.gov (United States)

    Pavel, John T.; Hyde, Erin C.; Bruch, Martha D.

    2012-01-01

    This experiment introduced general chemistry students to the basic concepts of organic structures and to the power of spectroscopic methods for structure determination. Students employed a combination of IR and NMR spectroscopy to perform de novo structure determination of unknown alcohols, without being provided with a list of possible…

  1. A new general dynamic model predicting radionuclide concentrations and fluxes in coastal areas from readily accessible driving variables

    International Nuclear Information System (INIS)

    Haakanson, Lars

    2004-01-01

    This paper presents a general, process-based dynamic model for coastal areas for radionuclides (metals, organics and nutrients) from both single pulse fallout and continuous deposition. The model gives radionuclide concentrations in water (total, dissolved and particulate phases and concentrations in sediments and fish) for entire defined coastal areas. The model gives monthly variations. It accounts for inflow from tributaries, direct fallout to the coastal area, internal fluxes (sedimentation, resuspension, diffusion, burial, mixing and biouptake and retention in fish) and fluxes to and from the sea outside the defined coastal area and/or adjacent coastal areas. The fluxes of water and substances between the sea and the coastal area are differentiated into three categories of coast types: (i) areas where the water exchange is regulated by tidal effects; (ii) open coastal areas where the water exchange is regulated by coastal currents; and (iii) semi-enclosed archipelago coasts. The coastal model gives the fluxes to and from the following four abiotic compartments: surface water, deep water, ET areas (i.e., areas where fine sediment erosion and transport processes dominate the bottom dynamic conditions and resuspension appears) and A-areas (i.e., areas of continuous fine sediment accumulation). Criteria to define the boundaries for the given coastal area towards the sea, and to define whether a coastal area is open or closed are given in operational terms. The model is simple to apply since all driving variables may be readily accessed from maps and standard monitoring programs. The driving variables are: latitude, catchment area, mean annual precipitation, fallout and month of fallout and parameters expressing coastal size and form as determined from, e.g., digitized bathymetric maps using a GIS program. Selected results: the predictions of radionuclide concentrations in water and fish largely depend on two factors, the concentration in the sea outside the given

  2. A General Approach to Access Morphologies of Polyoxometalates in Solution by Using SAXS: An Ab Initio Modeling Protocol.

    Science.gov (United States)

    Li, Mu; Wang, Weiyu; Yin, Panchao

    2018-05-02

    Herein, we reported a general protocol for an ab initio modeling approach to deduce structure information of polyoxometalates (POMs) in solutions from scattering data collected by the small-angle X-ray scattering (SAXS) technique. To validate the protocol, the morphologies of a serious of known POMs in either aqueous or organic solvents were analyzed. The obtained particle morphologies were compared and confirmed with previous reported crystal structures. To extend the feasibility of the protocol to an unknown system of aqueous solutions of Na 2 MoO 4 with the pH ranging from -1 to 8.35, the formation of {Mo 36 } clusters was probed, identified, and confirmed by SAXS. The approach was further optimized with a multi-processing capability to achieve fast analysis of experimental data, thereby, facilitating in situ studies of formations of POMs in solutions. The advantage of this approach is to generate intuitive 3D models of POMs in solutions without confining information such as symmetries and possible sizes. © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  3. Quantitative ultrasonic evaluation of concrete structures using one-sided access

    Science.gov (United States)

    Khazanovich, Lev; Hoegh, Kyle

    2016-02-01

    Nondestructive diagnostics of concrete structures is an important and challenging problem. A recent introduction of array ultrasonic dry point contact transducer systems offers opportunities for quantitative assessment of the subsurface condition of concrete structures, including detection of defects and inclusions. The methods described in this paper are developed for signal interpretation of shear wave impulse response time histories from multiple fixed distance transducer pairs in a self-contained ultrasonic linear array. This included generalizing Kirchoff migration-based synthetic aperture focusing technique (SAFT) reconstruction methods to handle the spatially diverse transducer pair locations, creating expanded virtual arrays with associated reconstruction methods, and creating automated reconstruction interpretation methods for reinforcement detection and stochastic flaw detection. Interpretation of the reconstruction techniques developed in this study were validated using the results of laboratory and field forensic studies. Applicability of the developed methods for solving practical engineering problems was demonstrated.

  4. General theoretical description of angle-resolved photoemission spectroscopy of van der Waals structures

    Science.gov (United States)

    Amorim, B.

    2018-04-01

    We develop a general theory to model the angle-resolved photoemission spectroscopy (ARPES) of commensurate and incommensurate van der Waals (vdW) structures, formed by lattice mismatched and/or misaligned stacked layers of two-dimensional materials. The present theory is based on a tight-binding description of the structure and the concept of generalized umklapp processes, going beyond previous descriptions of ARPES in incommensurate vdW structures, which are based on continuous, low-energy models, being limited to structures with small lattice mismatch/misalignment. As applications of the general formalism, we study the ARPES bands and constant energy maps for two structures: twisted bilayer graphene and twisted bilayer MoS2. The present theory should be useful in correctly interpreting experimental results of ARPES of vdW structures and other systems displaying competition between different periodicities, such as two-dimensional materials weakly coupled to a substrate and materials with density wave phases.

  5. IFLA General Conference, 1986. Pre-Conference Seminar on Automated Systems for Access to Multilingual and Multiscript Library materials: Problems and Solutions. Papers.

    Science.gov (United States)

    International Federation of Library Associations and Institutions, The Hague (Netherlands).

    A seminar which considered problems and solutions regarding automated systems for access to multilingual and multiscript library materials was held as a pre-session before the IFLA general conference in 1986. Papers presented include: (1) "Romanized and Transliterated Databases of Asian Language Materials--History, Problems, and…

  6. Information-flow-based Access Control for Virtualized Systems

    Directory of Open Access Journals (Sweden)

    Dmitriy Aleksandrovich Postoev

    2014-12-01

    Full Text Available The article is devoted to the method of information-flow-based access control, adopted for virtualized systems. General structure of access control system for virtual infrastructure is proposed.

  7. Socio-political structure of Turkey in general elections (since 1950 up to 1980)

    OpenAIRE

    Ali Arslan

    2007-01-01

    This study aims to analyse socio-political structure of Turkish society at the basis of the results of Turkish General elections since 1950 up to 1980. Documentary and historical research techniques will be employed during the study.

  8. Linking temperature sensitivity of soil organic matter decomposition to its molecular structure, accessibility, and microbial physiology.

    Science.gov (United States)

    Wagai, Rota; Kishimoto-Mo, Ayaka W; Yonemura, Seiichiro; Shirato, Yasuhito; Hiradate, Syuntaro; Yagasaki, Yasumi

    2013-04-01

    Temperature sensitivity of soil organic matter (SOM) decomposition may have a significant impact on global warming. Enzyme-kinetic hypothesis suggests that decomposition of low-quality substrate (recalcitrant molecular structure) requires higher activation energy and thus has greater temperature sensitivity than that of high-quality, labile substrate. Supporting evidence, however, relies largely on indirect indices of substrate quality. Furthermore, the enzyme-substrate reactions that drive decomposition may be regulated by microbial physiology and/or constrained by protective effects of soil mineral matrix. We thus tested the kinetic hypothesis by directly assessing the carbon molecular structure of low-density fraction (LF) which represents readily accessible, mineral-free SOM pool. Using five mineral soil samples of contrasting SOM concentrations, we conducted 30-days incubations (15, 25, and 35 °C) to measure microbial respiration and quantified easily soluble C as well as microbial biomass C pools before and after the incubations. Carbon structure of LFs (soil was measured by solid-state (13) C-NMR. Decomposition Q10 was significantly correlated with the abundance of aromatic plus alkyl-C relative to O-alkyl-C groups in LFs but not in bulk soil fraction or with the indirect C quality indices based on microbial respiration or biomass. The warming did not significantly change the concentration of biomass C or the three types of soluble C despite two- to three-fold increase in respiration. Thus, enhanced microbial maintenance respiration (reduced C-use efficiency) especially in the soils rich in recalcitrant LF might lead to the apparent equilibrium between SOM solubilization and microbial C uptake. Our results showed physical fractionation coupled with direct assessment of molecular structure as an effective approach and supported the enzyme-kinetic interpretation of widely observed C quality-temperature relationship for short-term decomposition. Factors

  9. Structure identification and adaptive synchronization of uncertain general complex dynamical networks

    Energy Technology Data Exchange (ETDEWEB)

    Xu Yuhua, E-mail: yuhuaxu2004@163.co [College of Information Science and Technology, Donghua University, Shanghai 201620 (China) and Department of Maths, Yunyang Teacher' s College, Hubei 442000 (China); Zhou Wuneng, E-mail: wnzhou@163.co [College of Information Science and Technology, Donghua University, Shanghai 201620 (China); Fang Jian' an [College of Information Science and Technology, Donghua University, Shanghai 201620 (China); Lu Hongqian [Shandong Institute of Light Industry, Shandong Jinan 250353 (China)

    2009-12-28

    This Letter proposes an approach to identify the topological structure and unknown parameters for uncertain general complex networks simultaneously. By designing effective adaptive controllers, we achieve synchronization between two complex networks. The unknown network topological structure and system parameters of uncertain general complex dynamical networks are identified simultaneously in the process of synchronization. Several useful criteria for synchronization are given. Finally, an illustrative example is presented to demonstrate the application of the theoretical results.

  10. Structure identification and adaptive synchronization of uncertain general complex dynamical networks

    International Nuclear Information System (INIS)

    Xu Yuhua; Zhou Wuneng; Fang Jian'an; Lu Hongqian

    2009-01-01

    This Letter proposes an approach to identify the topological structure and unknown parameters for uncertain general complex networks simultaneously. By designing effective adaptive controllers, we achieve synchronization between two complex networks. The unknown network topological structure and system parameters of uncertain general complex dynamical networks are identified simultaneously in the process of synchronization. Several useful criteria for synchronization are given. Finally, an illustrative example is presented to demonstrate the application of the theoretical results.

  11. A generalized Tu formula and Hamiltonian structures of fractional AKNS hierarchy

    International Nuclear Information System (INIS)

    Wu, Guo-cheng; Zhang, Sheng

    2011-01-01

    In this Letter, a generalized Tu formula is firstly presented to construct Hamiltonian structures of fractional soliton equations. The obtained results can be reduced to the classical Hamiltonian hierarchy of AKNS in ordinary calculus. -- Highlights: → A generalized Tu formula is first established based on the fractional variational theory for non-differentiable functions. → Hamiltonian structures of fractional AKNS hierarchy are obtained. → The classical AKNS hierarchy is just a special case of the fractional hierarchy.

  12. A generalized Tu formula and Hamiltonian structures of fractional AKNS hierarchy

    Energy Technology Data Exchange (ETDEWEB)

    Wu, Guo-cheng, E-mail: wuguocheng2002@yahoo.com.cn [Key Laboratory of Numerical Simulation of Sichuan Province, Neijiang, Sichuan 641112 (China); College of Mathematics and Information Science, Neijiang Normal University, Neijiang, Sichuan 641112 (China); Zhang, Sheng, E-mail: zhshaeng@yahoo.com.cn [School of Mathematical Sciences, Dalian University of Technology, Dalian 116024 (China)

    2011-10-03

    In this Letter, a generalized Tu formula is firstly presented to construct Hamiltonian structures of fractional soliton equations. The obtained results can be reduced to the classical Hamiltonian hierarchy of AKNS in ordinary calculus. -- Highlights: → A generalized Tu formula is first established based on the fractional variational theory for non-differentiable functions. → Hamiltonian structures of fractional AKNS hierarchy are obtained. → The classical AKNS hierarchy is just a special case of the fractional hierarchy.

  13. A ground-base Radar network to access the 3D structure of MLT winds

    Science.gov (United States)

    Stober, G.; Chau, J. L.; Wilhelm, S.; Jacobi, C.

    2016-12-01

    The mesosphere/lower thermosphere (MLT) is a highly variable atmospheric region driven by wave dynamics at various scales including planetary waves, tides and gravity waves. Some of these propagate through the MLT into the thermosphere/ionosphere carrying energy and momentum from the middle atmosphere into the upper atmosphere. To improve our understanding of the wave energetics and momentum transfer during their dissipation it is essential to characterize their space time properties. During the last two years we developed a new experimental approach to access the horizontal structure of wind fields at the MLT using a meteor radar network in Germany, which we called MMARIA - Multi-static Multi-frequency Agile Radar for Investigation of the Atmosphere. The network combines classical backscatter meteor radars and passive forward scatter radio links. We present our preliminary results using up to 7 different active and passive radio links to obtain horizontally resolved wind fields applying a statistical inverse method. The wind fields are retrieved with 15-30 minutes temporal resolution on a grid with 30x30 km horizontal spacing. Depending on the number of observed meteors, we are able to apply the wind field inversion at heights between 84-94 km. The horizontally resolved wind fields provide insights of the typical horizontal gravity wave length and the energy cascade from large scales to small scales. We present first power spectra indicating the transition from the synoptic wave scale to the gravity wave scale.

  14. The impact of category structure and training methodology on learning and generalizing within-category representations.

    Science.gov (United States)

    Ell, Shawn W; Smith, David B; Peralta, Gabriela; Hélie, Sébastien

    2017-08-01

    When interacting with categories, representations focused on within-category relationships are often learned, but the conditions promoting within-category representations and their generalizability are unclear. We report the results of three experiments investigating the impact of category structure and training methodology on the learning and generalization of within-category representations (i.e., correlational structure). Participants were trained on either rule-based or information-integration structures using classification (Is the stimulus a member of Category A or Category B?), concept (e.g., Is the stimulus a member of Category A, Yes or No?), or inference (infer the missing component of the stimulus from a given category) and then tested on either an inference task (Experiments 1 and 2) or a classification task (Experiment 3). For the information-integration structure, within-category representations were consistently learned, could be generalized to novel stimuli, and could be generalized to support inference at test. For the rule-based structure, extended inference training resulted in generalization to novel stimuli (Experiment 2) and inference training resulted in generalization to classification (Experiment 3). These data help to clarify the conditions under which within-category representations can be learned. Moreover, these results make an important contribution in highlighting the impact of category structure and training methodology on the generalization of categorical knowledge.

  15. Typography for Graphic Communication [and] Typographic Access Structures for Educational Texts [and] Graphic Aspects of Complex Texts: Typography as Macropunctuation.

    Science.gov (United States)

    Waller, Robert

    The three papers included in this report address typography for graphic communication, typographic access structures for educational texts, and typography as macropunctuation. The first paper considers the consequences of an aesthetic bias in the literature of typography, and identifies two misleading assumptions about textbooks; i.e., that print…

  16. Nonstandard conserved Hamiltonian structures in dissipative/damped systems: Nonlinear generalizations of damped harmonic oscillator

    International Nuclear Information System (INIS)

    Pradeep, R. Gladwin; Chandrasekar, V. K.; Senthilvelan, M.; Lakshmanan, M.

    2009-01-01

    In this paper we point out the existence of a remarkable nonlocal transformation between the damped harmonic oscillator and a modified Emden-type nonlinear oscillator equation with linear forcing, xe+αxx+βx 3 +γx=0, which preserves the form of the time independent integral, conservative Hamiltonian, and the equation of motion. Generalizing this transformation we prove the existence of nonstandard conservative Hamiltonian structure for a general class of damped nonlinear oscillators including Lienard-type systems. Further, using the above Hamiltonian structure for a specific example, namely, the generalized modified Emden equation xe+αx q x+βx 2q+1 =0, where α, β, and q are arbitrary parameters, the general solution is obtained through appropriate canonical transformations. We also present the conservative Hamiltonian structure of the damped Mathews-Lakshmanan oscillator equation. The associated Lagrangian description for all the above systems is also briefly discussed.

  17. Structural Behavioral Study on the General Aviation Network Based on Complex Network

    Science.gov (United States)

    Zhang, Liang; Lu, Na

    2017-12-01

    The general aviation system is an open and dissipative system with complex structures and behavioral features. This paper has established the system model and network model for general aviation. We have analyzed integral attributes and individual attributes by applying the complex network theory and concluded that the general aviation network has influential enterprise factors and node relations. We have checked whether the network has small world effect, scale-free property and network centrality property which a complex network should have by applying degree distribution of functions and proved that the general aviation network system is a complex network. Therefore, we propose to achieve the evolution process of the general aviation industrial chain to collaborative innovation cluster of advanced-form industries by strengthening network multiplication effect, stimulating innovation performance and spanning the structural hole path.

  18. Open-access transvaginal sonography in women of reproductive age with abnormal vaginal bleeding: a descriptive study in general practice

    NARCIS (Netherlands)

    de Vries, Corlien J. H.; Wieringa-de Waard, Margreet; Bindels, Patrick J. E.; Ankum, Willem M.

    2011-01-01

    Diagnostic ultrasonography is used by GPs in approximately 10% of patients of reproductive age with abnormal vaginal bleeding. Transvaginal sonography is recommended as a first-line diagnostic instrument for assessing uterine pathology. To assess if findings resulting from open-access sonography

  19. Values, inter-attitudinal structure, and attitude change: value accessibility can increase a related attitude's resistance to change.

    Science.gov (United States)

    Blankenship, Kevin L; Wegener, Duane T; Murray, Renee A

    2015-12-01

    Accessibility is one of the most basic structural properties of an attitude and an important factor to consider in attitude strength. Despite its importance, relatively little work has examined the role of attitude accessibility in an inter-attitudinal context, particularly as it relates to the strength of related attitudes in the network. The present research examines accessibility as a property of one attitude (toward an abstract goal or end-state, that is, a value) that might influence the strength of a different but related attitude (toward a social policy conceptually related to the value). In Study 1, a highly accessible evaluative component of a value increased resistance to change of attitudes and behavioral intentions toward a social policy related to that value. Similarly, a manipulation of value accessibility (Studies 2 and 3) led to increased resistance of attitudes and behavioral intentions toward a social policy related to that value. Implications for the role of accessibility in inter-attitudinal strength are discussed. © 2015 by the Society for Personality and Social Psychology, Inc.

  20. Description of a general method to compute the fluid-structure interaction

    International Nuclear Information System (INIS)

    Jeanpierre, F.; Gibert, R.J.; Hoffmann, A.; Livolant, M.

    1979-01-01

    The vibrational characteristics of a structure in air may be considerably modified when the structure is immersed in a dense fluid. Such fluid structure interaction effects are important for the seismic or flow induced vibrational studies of various nuclear equipments, as for example the PWR internals, the fast reactor vessels, heat exchangers and fuel elements. In some simple situations, the fluid effects can be simulate by added masses, but in general, they are much more complicated. A general formulation to calculate precisely the vibrational behaviour of structures containing dense fluids is presented in this paper. That formulation can be easily introduced in finite elements computer codes, the fluid being described by special fluid elements. Its use is in principle limited to the linear range: small movements of structures, small pressure fluctuations. (orig.)

  1. Increasing Wage Gap, Spatial Structure and Market Access: Evidence from Swedish Micro Data

    OpenAIRE

    Nabavi, Pardis

    2015-01-01

    The new economic geography predicts that the wage gap will increase with accessibility to markets but does not consider the impact of spatial proximity. In contrast, urban economic theory explains wage differences by density without accounting for accessibility. Using a rich Swedish micro-panel, we empirically examine the two rival theories for males and females separately, controlling for individual, firm and regional characteristics. The regression results indicate that wage dispersion is c...

  2. [Access, use and preferences of Information and Communication Technologies by physicians in a general hospital in Peru].

    Science.gov (United States)

    Vásquez-Silva, Luis; Ticse, Ray; Alfaro-Carballido, Luz; Guerra-Castañon, Felix

    2015-01-01

    We assessed the access, use and preferences of information and communication technology (ICT) by physicians who practice at Cayetano Heredia National Hospital. The questionnaire explored the availability and skills of ICT, time, educational activities, search engines and technological applications most used as well as ICT preferences in education.211 physicians were surveyed; laptop use was 93%, tablet and smartphone use was 66% and 88%.68% have mobile Internet. Differences were evident in the frequency of use of ICT in 25-34 year old age group as well as a higher level of skills (pWhatsApp as a means of exchanging images and data related to health, 50% participated in medical blogs, online courses or videoconferences. The use and access of ICT is common among doctors in this hospital and there is positive interest in its use in education.

  3. Access, use and preferences of information and communication technologies by physicians in a general hospital in Peru

    OpenAIRE

    Vásquez-Silva, Luis; Facultad de Medicina. Universidad Peruana Cayetano Heredia. Lima, Perú. Hospital Nacional Cayetano Heredia. Lima, Perú.; Ticse, Ray; Facultad de Medicina. Universidad Peruana Cayetano Heredia. Lima, Perú. Hospital Nacional Cayetano Heredia. Lima, Perú.; Alfaro-Carballido, Luz; Hospital Nacional Cayetano Heredia. Lima, Perú.; Guerra-Castañon, Felix; Facultad de Medicina. Universidad Peruana Cayetano Heredia. Lima, Perú. Hospital Nacional Cayetano Heredia. Lima, Perú.

    2015-01-01

    We assessed the access, use and preferences of information and communication technology (ICT) by physicians who practice at Cayetano Heredia National Hospital. The questionnaire explored the availability and skills of ICT, time, educational activities, search engines and technological applications most used as well as ICT preferences in education.211 physicians were surveyed; laptop use was 93%, tablet and smartphone use was 66% and 88%.68% havemobile Internet. Differences were evident in the...

  4. Widening access to medicine may improve general practitioner recruitment in deprived and rural communities: survey of GP origins and current place of work.

    Science.gov (United States)

    Dowell, J; Norbury, M; Steven, K; Guthrie, B

    2015-10-01

    Widening access to medicine in the UK is a recalcitrant problem of increasing political importance, with associated strong social justice arguments but without clear evidence of impact on service delivery. Evidence from the United States suggests that widening access may enhance care to underserved communities. Additionally, rural origin has been demonstrated to be the factor most strongly associated with rural practice. However the evidence regarding socio-economic and rural background and subsequent practice locations in the UK has not been explored. The aim of this study was to investigate the association between general practitioners' (GPs) socio-economic and rural background at application to medical school and demographic characteristics of their current practice. The study design was a cross-sectional email survey of general practitioners practising in Scotland. Socio-economic status of GPs at application to medical school was assessed using the self-coded National Statistics Socio-Economic Classification. UK postcode at application was used to define urban-rural location. Current practice deprivation and remoteness was measured using NHS Scotland defined measures based on registered patients' postcodes. A survey was sent to 2050 Scottish GPs with a valid accessible email address, with 801 (41.5 %) responding. GPs whose parents had semi-routine or routine occupations had 4.3 times the odds of working in a deprived practice compared to those with parents from managerial and professional occupations (95 % CI 1.8-10.2, p = 0.001). GPs from remote and rural Scottish backgrounds were more likely to work in remote Scottish practices, as were GPs originating from other UK countries. This study showed that childhood background is associated with the population GPs subsequently serve, implying that widening access may positively affect service delivery in addition to any social justice rationale. Longitudinal research is needed to explore this association and the

  5. Application of Generalized Mie Theory to EELS Calculations as a Tool for Optimization of Plasmonic Structures

    DEFF Research Database (Denmark)

    Thomas, Stefan; Matyssek, Christian; Hergert, Wolfram

    2015-01-01

    Technical applications of plasmonic nanostructures require a careful structural optimization with respect to the desired functionality. The success of such optimizations strongly depends on the applied method. We extend the generalized multiparticle Mie (GMM) computational electromagnetic method ...... by the application of genetic algorithms combined with a simplex algorithm. The scheme is applied to the design of plasmonic filters.......Technical applications of plasmonic nanostructures require a careful structural optimization with respect to the desired functionality. The success of such optimizations strongly depends on the applied method. We extend the generalized multiparticle Mie (GMM) computational electromagnetic method...

  6. Analysis of Genetic Diversity and Population Structure of Sesame Accessions from Africa and Asia as Major Centers of Its Cultivation

    Directory of Open Access Journals (Sweden)

    Komivi Dossa

    2016-04-01

    Full Text Available Sesame is an important oil crop widely cultivated in Africa and Asia. Understanding the genetic diversity of accessions from these continents is critical to designing breeding methods and for additional collection of sesame germplasm. To determine the genetic diversity in relation to geographical regions, 96 sesame accessions collected from 22 countries distributed over six geographic regions in Africa and Asia were genotyped using 33 polymorphic SSR markers. Large genetic variability was found within the germplasm collection. The total number of alleles was 137, averaging 4.15 alleles per locus. The accessions from Asia displayed more diversity than those from Africa. Accessions from Southern Asia (SAs, Eastern Asia (EAs, and Western Africa (WAf were highly diversified, while those from Western Asia (WAs, Northern Africa (NAf, and Southeastern Africa (SAf had the lowest diversity. The analysis of molecular variance revealed that more than 44% of the genetic variance was due to diversity among geographic regions. Five subpopulations, including three in Asia and two in Africa, were cross-identified through phylogenetic, PCA, and STRUCTURE analyses. Most accessions clustered in the same population based on their geographical origins. Our results provide technical guidance for efficient management of sesame genetic resources in breeding programs and further collection of sesame germplasm from these different regions.

  7. Algebraic structures in generalized Clifford analysis and applications to boundary value problems

    Directory of Open Access Journals (Sweden)

    José Játem

    2015-12-01

    Full Text Available The present article has a threefold purpose: First it is a survey of the algebraic structures of generalized Clifford-type algebras and shows the main results of the corresponding Clifford-type analysis and its application to boundary value problems known so far. Second it is aimed to implement algorithms to provide the fast and accurate computation of boundary value problems for inhomogeneous equations in the framework of the generalized Clifford analysis. Finally it is also aimed to encourage the development of a generalized discrete Clifford analysis.

  8. Optimization of power plants management structure based on the generalized criteria of the efficiency

    Directory of Open Access Journals (Sweden)

    Salov Aleksey

    2017-01-01

    Full Text Available In the article, the analysis of the operation of power plants in the conditions of economic restructuring to ensure successful entry into the market is carried out. The analysis of the five management structures, including current, typical structure and re-designed by the authors is presented. There are developed the partial efficiency criteria of the management structures that characterize the most important properties - the balance, integrity, controllability and stability. Local criteria of the analyzed structures do not allow to make a definite conclusion about the effectiveness of one of the structures analyzed, formulated global efficiency criterion. There is developed the global criterion of the comparative effectiveness of the management systems based on the DEA method (Data envelopment analysis, taking into account the complex of the proposed local criteria. The considered management structures are ranked based on the generalized criterion of efficiency.

  9. Use of the objective structured clinical examination for assessment of vocational trainees for general practice

    OpenAIRE

    Walker, Robert; Walker, Barrie

    1987-01-01

    General practice training schemes currently have no structured methods of assessment and most rely on a variety of subjective ratings of performance. In West Cumbria the `objective structured clinical examination' has been used to assess training performance in areas covered by small group teaching during the preceding terms. Consultation skills, interpretation of clinical data and a number of aspects of practice management were tested. The examination was conducted in the local postgraduate ...

  10. Distributed probing of chromatin structure in vivo reveals pervasive chromatin accessibility for expressed and non-expressed genes during tissue differentiation in C. elegans

    Directory of Open Access Journals (Sweden)

    Sha Ky

    2010-08-01

    Full Text Available Abstract Background Tissue differentiation is accompanied by genome-wide changes in the underlying chromatin structure and dynamics, or epigenome. By controlling when, where, and what regulatory factors have access to the underlying genomic DNA, the epigenome influences the cell's transcriptome and ultimately its function. Existing genomic methods for analyzing cell-type-specific changes in chromatin generally involve two elements: (i a source for purified cells (or nuclei of distinct types, and (ii a specific treatment that partitions or degrades chromatin by activity or structural features. For many cell types of great interest, such assays are limited by our inability to isolate the relevant cell populations in an organism or complex tissue containing an intertwined mixture of other cells. This limitation has confined available knowledge of chromatin dynamics to a narrow range of biological systems (cell types that can be sorted/separated/dissected in large numbers and tissue culture models or to amalgamations of diverse cell types (tissue chunks, whole organisms. Results Transgene-driven expression of DNA/chromatin modifying enzymes provides one opportunity to query chromatin structures in expression-defined cell subsets. In this work we combine in vivo expression of a bacterial DNA adenine methyltransferase (DAM with high throughput sequencing to sample tissue-specific chromatin accessibility on a genome-wide scale. We have applied the method (DALEC: Direct Asymmetric Ligation End Capture towards mapping a cell-type-specific view of genome accessibility as a function of differentiated state. Taking advantage of C. elegans strains expressing the DAM enzyme in diverse tissues (body wall muscle, gut, and hypodermis, our efforts yield a genome-wide dataset measuring chromatin accessibility at each of 538,000 DAM target sites in the C. elegans (diploid genome. Conclusions Validating the DALEC mapping results, we observe a strong association

  11. A cross-sectional survey of the access of older people in the Scottish Highlands to general medical practices, community pharmacies and prescription medicines.

    Science.gov (United States)

    Rushworth, Gordon F; Cunningham, Scott; Pfleger, Sharon; Hall, Jenny; Stewart, Derek

    2018-01-01

    Access to medicines and healthcare is more problematic in remote and rural areas. To quantify issues of access to general practitioners (GPs), community pharmacies and prescribed medicines in older people resident in the Scottish Highlands. Anonymized questionnaires were mailed to a random sample of 2000 older people (≥60 years) resident in the Scottish Highlands. Questionnaire items were: access and convenience to GP and pharmacy services (10 items); prescribed medicines (13 items); attitudinal statements based on the Theoretical Domains Framework (12 items); quality of life (SF8, 8 items); and demographics (12 items). Results were analysed using descriptive, inferential and spatial statistics, and principal component analysis (PCA) of attitudinal items. With a response rate of 54.2%, the majority reported convenient access to GPs (89.1%) and community pharmacies (84.3%). Older age respondents (p rural areas to community pharmacies (p rural areas and taking five or more prescribed medicines. Copyright © 2017 Elsevier Inc. All rights reserved.

  12. INCREASE IN THE ROLE OF THE FINANCIAL SYNTHESIS REPORTS FOR ACCESSION OF THE EUROPEAN STRUCTURAL FUNDS

    Directory of Open Access Journals (Sweden)

    Droj Laurentiu

    2011-07-01

    Full Text Available European integration is supported through important financial resources in order to sustain the investment effort for aligning the business infrastructure and increase in the business competitiveness in order to fulfill the European Union standards. The financial management, a basic component of the general management, has as scope to realize complex financial analysis in order to substantiate the decisions for investments and financing which should ensure the maximization of results, ensuring also the elaboration of the project budget as an essential document in the identification of the needs for resources and for obtaining the non-reimbursable financial sources. An essential role in the investment decision making, having as support European funding, is realized by the financial-accounting reporting documents such as balance sheet, profit and loss account, table of the treasury flows, which together with a realistic established actualization rate ensures the relevance and efficiency of the financial indicators: Net present Value(NPV, Internal Rate of Return(IRR, the investment recovery period, the benefit/cost ratio. This study has as its goal to realize a critical analysis over the main simulation methods and techniques for forecasting annual return based on its growth rate, which should ensure the success of the implementation and operation of an investment realized through European structural funds respecting also the requirements for minimization of risks. In this research it is shown the importance of proper generation/modeling of the annual turnover in an investment project. Several methods were presented and case study was realized. Since the annual turnover constitutes the basis for the entire financial analysis it is very important that a realistic growth rate is used. Otherwise the provisions within the financial analysis of the investment (including CBA, the project implementation strategy and later the plan for the utilization of

  13. Structural Impediments to Condom Access in a High HIV/STI-Risk Area

    Directory of Open Access Journals (Sweden)

    Christine Rizkalla

    2010-01-01

    Full Text Available As embarrassment is a known obstacle to condom acquisition, selling condoms from physically inaccessible places that require personnel assistance constitutes a barrier to access. This study investigates the extent of this barrier in the Bronx, a high HIV/STI prevalence county of New York. 75 of 320 listed Bronx pharmacies were sampled via computer randomization. Investigators coded condom placement and physical accessibility within these pharmacies and 140 surrounding stores. 91% of sites sold condoms. In 82%, condoms could not be accessed without assistance. Condoms were physically inaccessible in venues most encountered in the community: grocery stores versus pharmacies (OR=15; 95% CI, 5–48, independent versus chain pharmacies (OR=32; 95% CI, 6–235. They were physically inaccessible more in the lowest SES/highest HIV prevalence areas versus the highest SES/lowest HIV prevalence areas (OR = 4.3, 95% CI, 1.1–17. Findings can inform efforts to increase accessibility of condoms, distribute condoms in alternative settings, and prompt similar investigations in other high-risk communities.

  14. Hamiltonian structure and Darboux theorem for families of generalized Lotka-Volterra systems

    Science.gov (United States)

    Hernández-Bermejo, Benito; Fairén, Víctor

    1998-11-01

    This work is devoted to the establishment of a Poisson structure for a format of equations known as generalized Lotka-Volterra systems. These equations, which include the classical Lotka-Volterra systems as a particular case, have been deeply studied in the literature. They have been shown to constitute a whole hierarchy of systems, the characterization of which is made in the context of simple algebra. Our main result is to show that this algebraic structure is completely translatable into the Poisson domain. Important Poisson structures features, such as the symplectic foliation and the Darboux canonical representation, rise as a result of rather simple matrix manipulations.

  15. Methods of generalizing and classifying layer structures of a special form

    Energy Technology Data Exchange (ETDEWEB)

    Viktorova, N P

    1981-09-01

    An examination is made of the problem of classifying structures represented by weighted multilayer graphs of special form with connections between the vertices of each layer. The classification of structures of such a form is based on the construction of resolving sets of graphs as a result of generalization of the elements of the training sample of each class and the testing of whether an input object is isomorphic (with allowance for the weights) to the structures of the resolving set or not. 4 references.

  16. General structure of a two-body operator for spin-(1/2) particles

    International Nuclear Information System (INIS)

    Ershov, S.N.

    2004-01-01

    A direct derivation of the operator structure for two spin-(1/2) particles is presented subject to invariance under basic symmetries and Galilean frame transformation. The partial wave decomposition for coefficient functions, valid on- and off-shell, is explicitly deduced. The momentum transfer representation and angular momentum decomposition for general spin-dependent potentials are obtained

  17. General requirements for concrete containment structures for CANDU nuclear power plants

    International Nuclear Information System (INIS)

    1993-07-01

    This standard provides the general requirements used in the design, construction, testing, and commissioning of concrete containment structures for CANDU nuclear power plants designated as class containment and is directed to the owners, designers, manufacturers, fabricators, and constructors of the concrete components and parts

  18. Longitudinal Factor Structure of General Self-Concept and Locus of Control among High School Students

    Science.gov (United States)

    Wang, Ze; Su, Ihui

    2013-01-01

    This study examined the longitudinal factor structure of general self-concept and locus of control among high school students over a 4-year period, with data from the National Educational Longitudinal Study of 1988. Measurement invariance was tested over time and across gender and ethnic groups; second-order piecewise latent growth models were…

  19. Generalized internal long wave equations: construction, hamiltonian structure and conservation laws

    International Nuclear Information System (INIS)

    Lebedev, D.R.

    1982-01-01

    Some aspects of the theory of the internal long-wave equations (ILW) are considered. A general class of the ILW type equations is constructed by means of the Zakharov-Shabat ''dressing'' method. Hamiltonian structure and infinite numbers of conservation laws are introduced. The considered equations are shown to be Hamiltonian in the so-called second Hamiltonian structu

  20. The structure of psychopathology in adolescence : Replication of a general psychopathology factor in the TRAILS study

    NARCIS (Netherlands)

    Laceulle, O.M.; Vollebergh, W.A.M.; Ormel, J.

    2015-01-01

    This study aimed to replicate a study by Caspi and colleagues, which proposed that the structure of psychopathology is characterized by a general psychopathology factor, in addition to smaller internalizing and externalizing factors. Our study expanded the approach of the original by using

  1. The general form of the relaxation of a purely interfacial energy for structured deformations

    Czech Academy of Sciences Publication Activity Database

    Šilhavý, Miroslav

    2017-01-01

    Roč. 5, č. 2 (2017), s. 191-215 ISSN 2326-7186 Institutional support: RVO:67985840 Keywords : structured deformations * relaxation * subadditive envelope * interfacial energy Subject RIV: BA - General Mathematics OBOR OECD: Applied mathematics http://msp.org/memocs/2017/5-2/p04.xhtml

  2. Waves and Structures in Nonlinear Nondispersive Media General Theory and Applications to Nonlinear Acoustics

    CERN Document Server

    Gurbatov, S N; Saichev, A I

    2012-01-01

    "Waves and Structures in Nonlinear Nondispersive Media: General Theory and Applications to Nonlinear Acoustics” is devoted completely to nonlinear structures. The general theory is given here in parallel with mathematical models. Many concrete examples illustrate the general analysis of Part I. Part II is devoted to applications to nonlinear acoustics, including specific nonlinear models and exact solutions, physical mechanisms of nonlinearity, sawtooth-shaped wave propagation, self-action phenomena, nonlinear resonances and engineering application (medicine, nondestructive testing, geophysics, etc.). This book is designed for graduate and postgraduate students studying the theory of nonlinear waves of various physical nature. It may also be useful as a handbook for engineers and researchers who encounter the necessity of taking nonlinear wave effects into account of their work. Dr. Gurbatov S.N. is the head of Department, and Vice Rector for Research of Nizhny Novgorod State University. Dr. Rudenko O.V. is...

  3. Material dynamics in polluted soils with different structures - comparative investigations of general soil and aggregates

    International Nuclear Information System (INIS)

    Taubner, H.

    1992-01-01

    In structured soils, a small-scale heterogeneity of physical and chemical properties will develop which results in a reduced availability of the reaction sites of the soil matrix. In view of the lack of knowledge on the conditions within the individual aggregates were carried out for characterizing the aggregates and comparing them with the soil in, general soil samples were taken from natural structure of a podzolic soil and a podazolic brown earth from two sites in the Fichtelgebirge mountains as well as a parabraun earth from East Holstein. The horizons differed with regard to their texture and structure; silty material tends to have a subpolyhedral structure and calyey material a polyhedral structure. The general soil samples and aggregate samples from the three B horizons were subjected, with comparable experimental conditions, to percolation experiments inducing a multiple acid load. The soil solution from the secondary pore system and aggregate pore system is more heterogeneus for the higher-structured subpolyhedral texture of the perdzolic soil than for the less strongly aggregated subpolyhedral structured of the podzolic brown earth. (orig.) [de

  4. Genetic diversity and a population structure analysis of accessions in the Chinese cowpea [Vigna unguiculata (L. Walp.] germplasm collection

    Directory of Open Access Journals (Sweden)

    Honglin Chen

    2017-10-01

    Full Text Available Cowpea (Vigna unguiculata is an important legume crop with diverse uses. The species is presently a minor crop, and evaluation of its genetic diversity has been very limited. In this study, a total of 200 genic and 100 genomic simple sequence repeat (SSR markers were developed from cowpea unigene and genome sequences, respectively. Among them, 27 genic and 27 genomic SSR markers were polymorphic and were used for assessment of genetic diversity and population structure in 105 selected cowpea accessions. A total of 155 alleles and 2.9 alleles per marker were identified, and the average polymorphic information content (PIC value was 0.3615. The average PIC of genomic SSRs (0.3996 was higher than that of genic SSRs (0.3235, and most of the polymorphic genomic SSRs were composed of di- and trinucleotide repeats (51.9% and 37.0% of all loci, respectively. The low level of detected genetic diversity may be attributed to a severe genetic bottleneck that occurred during the cowpea domestication process. The accessions were classified by structure and cluster analysis into four subgroups that correlated well with their geographic origins or collection sites. The classification results were also consistent with the results from principal coordinate analysis and can be used as a guide during future germplasm collection and selection of accessions as breeding materials for cultivar improvement. The newly developed genic and genomic SSR markers described in this study will be valuable genomic resources for the assessment of genetic diversity, population structure, evaluation of germplasm accessions, construction of genetic maps, identification of genes of interest, and application of marker-assisted selection in cowpea breeding programs.

  5. Welfare versus market access : the implications of tariff structure for tariff reform

    OpenAIRE

    James E. Anderson; J. Peter Neary

    2004-01-01

    We show that the effects of tariff changes on welfare and import volume can be fully characterised by their effects on the generalised mean and variance of the tariff distribution. Using these tools, we derive new results for welfare- and market-access-improving tariff changes, which imply two "cones of liberalisation" in price space. Because welfare is negatively but import volume positively related to the generalised variance, the cones do not intersect, which poses a dilemma for trad...

  6. On the TDD Subframe Structure for Beyond 4G Radio Access Network

    DEFF Research Database (Denmark)

    Lähetkangas, Eeva; Pajukoski, Kari; Tiirola, Esa

    2013-01-01

    The purpose of a Beyond 4G (B4G) radio access technology, is to cope with the expected exponential increase of mobile data traffic in local area (LA). The requirements related to physical layer control signaling latencies and to hybrid ARQ (HARQ) round trip time (RTT) are in the order of ~1ms...... requirement and significant control signaling latency reductions compared to existing LTE-Advanced and WiMAX technologies....

  7. Structural barriers to HIV prevention among men who have sex with men (MSM) in Vietnam: Diversity, stigma, and healthcare access.

    Science.gov (United States)

    Philbin, Morgan M; Hirsch, Jennifer S; Wilson, Patrick A; Ly, An Thanh; Giang, Le Minh; Parker, Richard G

    2018-01-01

    Men who have sex with men (MSM) in Vietnam experience disproportionate rates of HIV infection. To advance understanding of how structural barriers may shape their engagement with HIV prevention services, we draw on 32 in-depth interviews and four focus groups (n = 31) conducted with MSM in Hanoi between October 2015- March 2016. Three primary factors emerged: (1) Diversity, both in relation to identity and income; Vietnamese MSM described themselves as segregated into Bóng kín (hidden, often heterosexually-identified MSM) and Bóng lộ ('out,' transgender, or effeminate MSM). Lower-income, 'hidden' MSM from rural areas were reluctant to access MSM-targeted services; (2) Stigma: MSM reported being stigmatized by the healthcare system, family, and other MSM; and (3) Healthcare access: this was limited due to economic barriers and lack of MSM-friendly services. Our research suggests the need for multiple strategies to reach diverse types of MSM as well as to address barriers in access to health services such as stigma and costs. While a great deal has been written about the diversity of MSM in relation to gender performance and sexual identities, our research points to the substantial structural-level barriers that must be addressed in order to achieve meaningful and effective HIV prevention for MSM worldwide.

  8. Genetic diversity and population structure of Pisum sativum accessions for marker-trait association of lipid content

    Directory of Open Access Journals (Sweden)

    Sajjad Ahmad

    2015-06-01

    Full Text Available Field pea (Pisum sativum L. is an important protein-rich pulse crop produced globally. Increasing the lipid content of Pisum seeds through conventional and contemporary molecular breeding tools may bring added value to the crop. However, knowledge about genetic diversity and lipid content in field pea is limited. An understanding of genetic diversity and population structure in diverse germplasm is important and a prerequisite for genetic dissection of complex characteristics and marker-trait associations. Fifty polymorphic microsatellite markers detecting a total of 207 alleles were used to obtain information on genetic diversity, population structure and marker-trait associations. Cluster analysis was performed using UPGMA to construct a dendrogram from a pairwise similarity matrix. Pea genotypes were divided into five major clusters. A model-based population structure analysis divided the pea accessions into four groups. Percentage lipid content in 35 diverse pea accessions was used to find potential associations with the SSR markers. Markers AD73, D21, and AA5 were significantly associated with lipid content using a mixed linear model (MLM taking population structure (Q and relative kinship (K into account. The results of this preliminary study suggested that the population could be used for marker-trait association mapping studies.

  9. Low-Cost Quality Control and Nondestructive Evaluation Technologies for General Aviation Structures

    Science.gov (United States)

    Cramer, K. Elliott; Gavinsky, Bob; Semanskee, Grant

    1998-01-01

    NASA's Advanced General Aviation Transport Experiments (AGATE) Program has as a goal to reduce the overall cost of producing private aviation aircraft while maintaining the safety of these aircraft. In order to successfully meet this goal, it is necessary to develop nondestructive inspection techniques which will facilitate the production of the materials used in these aircraft and assure the quality necessary to maintain airworthiness. This paper will discuss a particular class of general aviation materials and several nondestructive inspection techniques that have proven effective for making these inspections. Additionally, this paper will discuss the investigation and application of other commercially available quality control techniques applicable to these structures.

  10. Capturing hammerhead ribozyme structures in action by modulating general base catalysis.

    Directory of Open Access Journals (Sweden)

    Young-In Chi

    2008-09-01

    Full Text Available We have obtained precatalytic (enzyme-substrate complex and postcatalytic (enzyme-product complex crystal structures of an active full-length hammerhead RNA that cleaves in the crystal. Using the natural satellite tobacco ringspot virus hammerhead RNA sequence, the self-cleavage reaction was modulated by substituting the general base of the ribozyme, G12, with A12, a purine variant with a much lower pKa that does not significantly perturb the ribozyme's atomic structure. The active, but slowly cleaving, ribozyme thus permitted isolation of enzyme-substrate and enzyme-product complexes without modifying the nucleophile or leaving group of the cleavage reaction, nor any other aspect of the substrate. The predissociation enzyme-product complex structure reveals RNA and metal ion interactions potentially relevant to transition-state stabilization that are absent in precatalytic structures.

  11. Structural analysis of anodic porous alumina used for resistive random access memory

    International Nuclear Information System (INIS)

    Lee, Jeungwoo; Nigo, Seisuke; Kato, Seiichi; Kitazawa, Hideaki; Kido, Giyuu; Nakano, Yoshihiro

    2010-01-01

    Anodic porous alumina with duplex layers exhibits a voltage-induced switching effect and is a promising candidate for resistive random access memory. The nanostructural analysis of porous alumina is important for understanding the switching effect. We investigated the difference between the two layers of an anodic porous alumina film using transmission electron microscopy and electron energy-loss spectroscopy. Diffraction patterns showed that both layers are amorphous, and the electron energy-loss spectroscopy indicated that the inner layer contains less oxygen than the outer layer. We speculate that the conduction paths are mostly located in the oxygen-depleted area.

  12. Global structure of curves from generalized unitarity cut of three-loop diagrams

    International Nuclear Information System (INIS)

    Hauenstein, Jonathan D.; Huang, Rijun; Mehta, Dhagash; Zhang, Yang

    2015-01-01

    This paper studies the global structure of algebraic curves defined by generalized unitarity cut of four-dimensional three-loop diagrams with eleven propagators. The global structure is a topological invariant that is characterized by the geometric genus of the algebraic curve. We use the Riemann-Hurwitz formula to compute the geometric genus of algebraic curves with the help of techniques involving convex hull polytopes and numerical algebraic geometry. Some interesting properties of genus for arbitrary loop orders are also explored where computing the genus serves as an initial step for integral or integrand reduction of three-loop amplitudes via an algebraic geometric approach.

  13. Is there a domain-general cognitive structuring system? Evidence from structural priming across music, math, action descriptions, and language.

    Science.gov (United States)

    Van de Cavey, Joris; Hartsuiker, Robert J

    2016-01-01

    Cognitive processing in many domains (e.g., sentence comprehension, music listening, and math solving) requires sequential information to be organized into an integrational structure. There appears to be some overlap in integrational processing across domains, as shown by cross-domain interference effects when for example linguistic and musical stimuli are jointly presented (Koelsch, Gunter, Wittfoth, & Sammler, 2005; Slevc, Rosenberg, & Patel, 2009). These findings support theories of overlapping resources for integrational processing across domains (cfr. SSIRH Patel, 2003; SWM, Kljajevic, 2010). However, there are some limitations to the studies mentioned above, such as the frequent use of unnaturalistic integrational difficulties. In recent years, the idea has risen that evidence for domain-generality in structural processing might also be yielded though priming paradigms (cfr. Scheepers, 2003). The rationale behind this is that integrational processing across domains regularly requires the processing of dependencies across short or long distances in the sequence, involving respectively less or more syntactic working memory resources (cfr. SWM, Kljajevic, 2010), and such processing decisions might persist over time. However, whereas recent studies have shown suggestive priming of integrational structure between language and arithmetics (though often dependent on arithmetic performance, cfr. Scheepers et al., 2011; Scheepers & Sturt, 2014), it remains to be investigated to what extent we can also find evidence for priming in other domains, such as music and action (cfr. SWM, Kljajevic, 2010). Experiment 1a showed structural priming from the processing of musical sequences onto the position in the sentence structure (early or late) to which a relative clause was attached in subsequent sentence completion. Importantly, Experiment 1b showed that a similar structural manipulation based on non-hierarchically ordered color sequences did not yield any priming effect

  14. Structure of the generalized momentum of a test charged particle and the inverse problem in general relativity theory

    International Nuclear Information System (INIS)

    Zakharov, A.V.; Singatullin, R.S.

    1981-01-01

    The inverse problem is solved in general relativity theory (GRT) consisting in determining the metric and potentials of an electromagnetic field by their values in the nonsingular point of the V 4 space and present functions, being the generalized momenta of a test charged particle. The Hamilton-Jacobi equation for a test charged particle in GRT is used. The general form of the generalized momentum dependence on the initial values is determined. It is noted that the inverse problem solution of dynamics in GRT contains arbitrariness which depends on the choice of the metric and potential values of the electromagnetic field in the nonsingular point [ru

  15. Folding to Curved Surfaces: A Generalized Design Method and Mechanics of Origami-based Cylindrical Structures

    Science.gov (United States)

    Wang, Fei; Gong, Haoran; Chen, Xi; Chen, C. Q.

    2016-09-01

    Origami structures enrich the field of mechanical metamaterials with the ability to convert morphologically and systematically between two-dimensional (2D) thin sheets and three-dimensional (3D) spatial structures. In this study, an in-plane design method is proposed to approximate curved surfaces of interest with generalized Miura-ori units. Using this method, two combination types of crease lines are unified in one reprogrammable procedure, generating multiple types of cylindrical structures. Structural completeness conditions of the finite-thickness counterparts to the two types are also proposed. As an example of the design method, the kinematics and elastic properties of an origami-based circular cylindrical shell are analysed. The concept of Poisson’s ratio is extended to the cylindrical structures, demonstrating their auxetic property. An analytical model of rigid plates linked by elastic hinges, consistent with numerical simulations, is employed to describe the mechanical response of the structures. Under particular load patterns, the circular shells display novel mechanical behaviour such as snap-through and limiting folding positions. By analysing the geometry and mechanics of the origami structures, we extend the design space of mechanical metamaterials and provide a basis for their practical applications in science and engineering.

  16. On global structure of general solution of the Chew-Sow equations

    International Nuclear Information System (INIS)

    Gerdt, V.P.

    1981-01-01

    The Chew-Low equations for static p-wave πN-scattering are considered. The equations are formulated in the form of a system of three nonlinear difference equations of the first order which have the general solution depending on three arbitrary periodic functions. An approach to the global construction of the general solution is suggested which is based on the series expansion in powers of one of the arbitrary functions C(ω) determining the structure of the invariant curve for the Chew-Low equations. It is shown that the initial nonlinear problem is reduced to the linear one in every order in C(ω). By means of solving the linear problem the general solution is found in the first-order approximation in C(ω) [ru

  17. Relation of a unified quantum field theory of spinors to the structure of general relativity

    International Nuclear Information System (INIS)

    Kober, Martin

    2009-01-01

    Based on a unified quantum field theory of spinors assumed to describe all matter fields and their interactions we construct the space-time structure of general relativity according to a general connection within the corresponding spinor space. The tetrad field and the corresponding metric field are composed from a space-time dependent basis of spinors within the internal space of the fundamental matter field. Similar to twistor theory the Minkowski signature of the space-time metric is related to this spinor nature of elementary matter, if we assume the spinor space to be endowed with a symplectic structure. The equivalence principle and the property of background independence arise from the fact that all elementary fields are composed from the fundamental spinor field. This means that the structure of space-time according to general relativity seems to be a consequence of a fundamental theory of matter fields and not a presupposition as in the usual setting of relativistic quantum field theories.

  18. The Hubble law and the spiral structures of galaxies from equations of motion in general relativity

    International Nuclear Information System (INIS)

    Sachs, M.

    1975-01-01

    Fully exploiting the Lie group that characterizes the underlying symmetry of general relativity theory, Einstein's tensor formalism factorizes, yielding a generalized (16-component) quaternion field formalism. The associated generalized geodesic equation, taken as the equation of motion of a star, predicts the Hubble law from one approximation for the generally covariant equations of motion, and the spiral structure of galaxies from another approximation. These results depend on the imposition of appropriate boundary conditions. The Hubble law follows when the boundary conditions derive from the oscillating model cosmology, and not from the other cosmological models. The spiral structures of the galaxies follow from the same boundary conditions, but with a different time scale than for the whole universe. The solutions that imply the spiral motion are Fresnel integrals. These predict the star's motion to be along the 'Cornu Spiral'. The part of this spiral in the first quadrant is the imploding phase of the galaxy, corresponding to a motion with continually decreasing radii, approaching the galactic center as time increases. The part of the Cornu Spiral' in the third quadrant is the exploding phase, corresponding to continually increasing radii, as the star moves out from the hub. The spatial origin in the coordinate system of this curve is the inflection point, where the explosion changes to implosion. The two- (or many-) armed spiral galaxies are explained here in terms of two (or many) distinct explosions occurring at displaced times, in the domain of the rotating, planar galaxy. (author)

  19. How modification of accessible lysines to phenylalanine modulates the structural and functional properties of horseradish peroxidase: a simulation study.

    Directory of Open Access Journals (Sweden)

    Leila Navapour

    Full Text Available Horseradish Peroxidase (HRP is one of the most studied peroxidases and a great number of chemical modifications and genetic manipulations have been carried out on its surface accessible residues to improve its stability and catalytic efficiency necessary for biotechnological applications. Most of the stabilized derivatives of HRP reported to date have involved chemical or genetic modifications of three surface-exposed lysines (K174, K232 and K241. In this computational study, we altered these lysines to phenylalanine residues to model those chemical modifications or genetic manipulations in which these positively charged lysines are converted to aromatic hydrophobic residues. Simulation results implied that upon these substitutions, the protein structure becomes less flexible. Stability gains are likely to be achieved due to the increased number of stable hydrogen bonds, improved heme-protein interactions and more integrated proximal Ca2+ binding pocket. We also found a new persistent hydrogen bond between the protein moiety (F174 and the heme prosthetic group as well as two stitching hydrogen bonds between the connecting loops GH and F'F″ in mutated HRP. However, detailed analysis of functionally related structural properties and dynamical features suggests reduced reactivity of the enzyme toward its substrates. Molecular dynamics simulations showed that substitutions narrow the bottle neck entry of peroxide substrate access channel and reduce the surface accessibility of the distal histidine (H42 and heme prosthetic group to the peroxide and aromatic substrates, respectively. Results also demonstrated that the area and volume of the aromatic-substrate binding pocket are significantly decreased upon modifications. Moreover, the hydrophobic patch functioning as a binding site or trap for reducing aromatic substrates is shrunk in mutated enzyme. Together, the results of this simulation study could provide possible structural clues to explain

  20. Visit to general practitioners as a proxy for accessing chronic benefits by members of medical schemes, South Africa

    Directory of Open Access Journals (Sweden)

    Mncedisi M. Willie

    2012-10-01

    Full Text Available Background: Prescribed Minimum Benefits is a list of conditions that all medical schemes need to cover in full, and includes a select of chronic conditions. Chronic conditions affect people’s lifestyles and require ongoing management over a period of years for long-term survival. Objectives: This study examined the association between prevalence of selected chronic diseases and health service use, in particular visits to general practitioners (GPs by medical scheme members. Method: This was a retrospective study on medical schemes data. The median imputation method was employed to deal with missing and unreported chronic diseases prevalence. Multivariate logistic regression analysis was employed to assess effects of chronic disease prevalence, age stratum and scheme size on GP visits per annum. Results: The study showed that prevalence of asthma was significantly associated with more than three GP visits (OR = 1.081; 95% CI = 1.008–1.159, as was prevalence of type 2 diabetes (OR = 1.087; 95% CI = 1.027–1.152, whilst prevalence of hyperlipidaemia (OR = 0.92; 95% CI = 0.875–0.97 was more likely to be associated with less than three GP visits. Prevalence of hypertension was associated with more than three GP visits per year (OR = 1.132; 95% CI = 1.017–1.26. Conclusion: This study shows that scheme size, prevalence of chronic diseases such as asthma, type 2 diabetes, hyperlipidaemia and hypertension are related to GP visits. GPs and managed care programmes employed by schemes should give special attention to certain disease states with high prevalence rates in an effort to better manage them.

  1. History and structures of telecommunication in pathology, focusing on open access platforms.

    Science.gov (United States)

    Kayser, Klaus; Borkenfeld, Stephan; Djenouni, Amina; Kayser, Gian

    2011-11-07

    Telecommunication has matured to a broadly applied tool in diagnostic pathology. Contemporary with the development of fast electronic communication lines (Integrated digital network services (ISDN), broad band connections, and fibre optics, as well as the digital imaging technology (digital camera), telecommunication in tissue--based diagnosis (telepathology) has matured. Open access (internet) and server--based communication have induced the development of specific medical information platforms, such as iPATH, UICC-TPCC (telepathology consultation centre of the Union International against Cancer), or the Armed Forces Institute of Pathology (AFIP) teleconsultation system. They have been closed, and are subject to be replaced by specific open access forums (Medical Electronic Expert Communication System (MECES) with embedded virtual slide (VS) technology). MECES uses php language, data base driven mySqL architecture, X/L-AMPP infrastructure, and browser friendly W3C conform standards. The server--based medical communication systems (AFIP, iPATH, UICC-TPCC) have been reported to be a useful and easy to handle tool for expert consultation. Correct sampling and evaluation of transmitted still images by experts reported revealed no or only minor differences to the original images and good practice of the involved experts. β tests with the new generation medical expert consultation systems (MECES) revealed superior results in terms of performance, still image viewing, and system handling, especially as this is closely related to the use of so--called social forums (facebook, youtube, etc.). In addition to the acknowledged advantages of the former established systems (assistance of pathologists working in developing countries, diagnosis confirmation, international information exchange, etc.), the new generation offers additional benefits such as acoustic information transfer, assistance in image screening, VS technology, and teaching in diagnostic sampling, judgement

  2. The subliminal mere exposure effect does not generalize to structurally related stimuli.

    Science.gov (United States)

    Newell, Ben R; Bright, James E H

    2003-03-01

    R.F. Bornstein (1994) questioned whether subliminal mere exposure effects might generalize to structurally related stimuli, thereby providing evidence for the existence of implicit learning. Two experiments examined this claim using letter string stimuli constructed according to the rules of an artificial grammar. Experiment 1 demonstrated that brief, masked exposure to grammatical strings impaired recognition but failed to produce a mere exposure effect on novel structurally related strings seen at test. Experiment 2 replicated this result but also demonstrated that a reliable mere exposure effect could be obtained, provided the same grammatical strings were presented at test. The results suggest that the structural relationship between training and test items prevents the mere exposure effect when participants are unaware of the exposure status of stimuli, and therefore provide no evidence for the existence of implicit learning.

  3. Traffic Load on Interconnection Lines of Generalized Double Ring Network Structures

    DEFF Research Database (Denmark)

    Pedersen, Jens Myrup; Riaz, Muhammad Tahir; Madsen, Ole Brun

    2004-01-01

    Generalized Double Ring (N2R) network structures possess a number of good properties, but being not planar they are hard to physically embed in communication networks. However, if some of the lines, the interconnection lines, are implemented by wireless technologies, the remaining structure...... consists of two planar rings, which are easily embedded by fiber or other wired solutions. It is shown that for large N2R structures, the interconnection lines carry notably lower loads than the other lines if shortest-path routing is used, and the effects of two other routing schemes are explored, leading...... to lower load on interconnection lines at the price of larger efficient average distance and diameter....

  4. Effectiveness of strategies to encourage general practitioners to accept an offer of free access to online evidence-based information: a randomised controlled trial.

    Science.gov (United States)

    Buchan, Heather; Lourey, Emma; D'Este, Catherine; Sanson-Fisher, Rob

    2009-10-20

    This study examined the effectiveness of seven different interventions designed to increase the proportion of general practitioners (GPs) accepting an offer of free access to an online evidence-based resource. Australian GPs (n = 14,000) were randomly selected and assigned to seven intervention groups, with each receiving a different letter. Seven different strategies were used to encourage GPs to accept an offer of two years free access to an online evidence-based resource (BMJ Clinical Evidence). The first group received a standard letter of offer with no experimental demands. Groups two to seven received a standard letter of offer outlining the requirements of the study. They were asked to complete an initial online questionnaire, agree to complete a 12-month follow-up questionnaire, and agree to having data about their usage of the online evidence-based resource provided to researchers. Groups three to seven also had additional interventions included in the letter of offer: access to an online tutorial in use of the resource (group three); provision of a pamphlet with statements from influential opinion leaders endorsing the resource (group four); offer of eligibility to receive professional development points (group five); offer of eligibility for a prize of $500 for registration at a medical conference of their choice (group six); and a combination of some of the above interventions (group seven). In the group with no research demands, 27% accepted the offer. Average acceptance across all other groups was 10%. There was no advantage in using additional strategies such as financial incentives, opinion leader support, offer of professional development points, or an educational aid over a standard letter of offer to increase acceptance rates. This study showed low acceptance rates of the offer of access to the online resource when there was an associated requirement of response to a short online questionnaire and non-obtrusive monitoring of GP behaviour in terms

  5. Worldwide Protein Data Bank biocuration supporting open access to high-quality 3D structural biology data

    Science.gov (United States)

    Westbrook, John D; Feng, Zukang; Persikova, Irina; Sala, Raul; Sen, Sanchayita; Berrisford, John M; Swaminathan, G Jawahar; Oldfield, Thomas J; Gutmanas, Aleksandras; Igarashi, Reiko; Armstrong, David R; Baskaran, Kumaran; Chen, Li; Chen, Minyu; Clark, Alice R; Di Costanzo, Luigi; Dimitropoulos, Dimitris; Gao, Guanghua; Ghosh, Sutapa; Gore, Swanand; Guranovic, Vladimir; Hendrickx, Pieter M S; Hudson, Brian P; Ikegawa, Yasuyo; Kengaku, Yumiko; Lawson, Catherine L; Liang, Yuhe; Mak, Lora; Mukhopadhyay, Abhik; Narayanan, Buvaneswari; Nishiyama, Kayoko; Patwardhan, Ardan; Sahni, Gaurav; Sanz-García, Eduardo; Sato, Junko; Sekharan, Monica R; Shao, Chenghua; Smart, Oliver S; Tan, Lihua; van Ginkel, Glen; Yang, Huanwang; Zhuravleva, Marina A; Markley, John L; Nakamura, Haruki; Kurisu, Genji; Kleywegt, Gerard J; Velankar, Sameer; Berman, Helen M; Burley, Stephen K

    2018-01-01

    Abstract The Protein Data Bank (PDB) is the single global repository for experimentally determined 3D structures of biological macromolecules and their complexes with ligands. The worldwide PDB (wwPDB) is the international collaboration that manages the PDB archive according to the FAIR principles: Findability, Accessibility, Interoperability and Reusability. The wwPDB recently developed OneDep, a unified tool for deposition, validation and biocuration of structures of biological macromolecules. All data deposited to the PDB undergo critical review by wwPDB Biocurators. This article outlines the importance of biocuration for structural biology data deposited to the PDB and describes wwPDB biocuration processes and the role of expert Biocurators in sustaining a high-quality archive. Structural data submitted to the PDB are examined for self-consistency, standardized using controlled vocabularies, cross-referenced with other biological data resources and validated for scientific/technical accuracy. We illustrate how biocuration is integral to PDB data archiving, as it facilitates accurate, consistent and comprehensive representation of biological structure data, allowing efficient and effective usage by research scientists, educators, students and the curious public worldwide. Database URL: https://www.wwpdb.org/ PMID:29688351

  6. Romanian Minister of Education, Research, Youth and Sport, Daniel Petru Funeriu, and CERN Director General, Rolf Heuer, signed an agreement that formally recognises Romania as a Candidate for Accession to membership of CERN.

    CERN Multimedia

    Maximilien Brice

    2010-01-01

    Romanian Minister of Education, Research, Youth and Sport, Daniel Petru Funeriu, and CERN Director General, Rolf Heuer, signed an agreement that formally recognises Romania as a Candidate for Accession to membership of CERN.

  7. The Need for Open-access, Structured Data in Endocrine Research

    Directory of Open Access Journals (Sweden)

    Francesca Mastorci

    2015-01-01

    Full Text Available Data sharing has become a ‘hot topic’ for university librarians, faculty, and research centers, with particular focus within biomedical science, to prevent duplication of effort, promote scientific integrity, and permit the creation of new data sets when data from multiple sources are combined. However, access to and sharing of scientific data require substantial effort and investment to define specifications and generate requisite resources. Studies from well-designed and well-conducted medical registries can provide a real-world view of clinical practice, patient outcomes, safety, and may strengthen evidence-based decision making processes. At present, if cardiovascular data management has been sufficiently documented with data exchange in all clinical research, clinical registry, and patient care environments, including all electronic health records. It is nevertheless still necessary to create a database for endocrinology, particularly in light of new medical research that have blurred the concept of endocrinology as a discipline of basic science. The aim of this paper is to conceive datasets in endocrinology research and facilitate the exchange of data across studies and to promote interoperability between different research centres.

  8. Structure factors for tunneling ionization rates of molecules: General Hartree-Fock-based integral representation

    Science.gov (United States)

    Madsen, Lars Bojer; Jensen, Frank; Dnestryan, Andrey I.; Tolstikhin, Oleg I.

    2017-07-01

    In the leading-order approximation of the weak-field asymptotic theory (WFAT), the dependence of the tunneling ionization rate of a molecule in an electric field on its orientation with respect to the field is determined by the structure factor of the ionizing molecular orbital. The WFAT yields an expression for the structure factor in terms of a local property of the orbital in the asymptotic region. However, in general quantum chemistry approaches molecular orbitals are expanded in a Gaussian basis which does not reproduce their asymptotic behavior correctly. This hinders the application of the WFAT to polyatomic molecules, which are attracting increasing interest in strong-field physics. Recently, an integral-equation approach to the WFAT for tunneling ionization of one electron from an arbitrary potential has been developed. The structure factor is expressed in an integral form as a matrix element involving the ionizing orbital. The integral is not sensitive to the asymptotic behavior of the orbital, which resolves the difficulty mentioned above. Here, we extend the integral representation for the structure factor to many-electron systems treated within the Hartree-Fock method and show how it can be implemented on the basis of standard quantum chemistry software packages. We validate the methodology by considering noble-gas atoms and the CO molecule, for which accurate structure factors exist in the literature. We also present benchmark results for CO2 and for NH3 in the pyramidal and planar geometries.

  9. M-theory on eight-manifolds revisited: N = 1 supersymmetry and generalized Spin(7) structures

    International Nuclear Information System (INIS)

    Tsimpis, Dimitrios

    2006-01-01

    The requirement of N = 1 supersymmetry for M-theory backgrounds of the form of a warped product M x w X, where X is an eight-manifold and M is three-dimensional Minkowski or AdS space, implies the existence of a nowhere-vanishing Majorana spinor ξ on X. ξ lifts to a nowhere-vanishing spinor on the auxiliary nine-manifold Y: = X x S 1 , where S 1 is a circle of constant radius, implying the reduction of the structure group of Y to Spin(7). In general, however, there is no reduction of the structure group of X itself. This situation can be described in the language of generalized Spin(7) structures, defined in terms of certain spinors of Spin(TY+T*Y). We express the condition for N = 1 supersymmetry in terms of differential equations for these spinors. In an equivalent formulation, working locally in the vicinity of any point in X in terms of a 'preferred' Spin(7) structure, we show that the requirement of N = 1 supersymmetry amounts to solving for the intrinsic torsion and all irreducible flux components, except for the one lying in the 27 of Spin(7), in terms of the warp factor and a one-form L on X (not necessarily nowhere-vanishing) constructed as a ξ bilinear; in addition, L is constrained to satisfy a pair of differential equations. The formalism based on the group Spin(7) is the most suitable language in which to describe supersymmetric compactifications on eight-manifolds of Spin(7) structure, and/or small-flux perturbations around supersymmetric compactifications on manifolds of Spin(7) holonomy

  10. Does access to general dental treatment affect the number and complexity of patients presenting to the acute hospital service with severe dentofacial infections?

    Science.gov (United States)

    Bowe, Conor M; Gargan, Mary Louise; Kearns, Gerard J; Stassen, Leo F A

    2015-01-01

    This is a retrospective study to review the treatment and management of patients presenting with odontogenic infections in a large urban teaching hospital over a four-year period, comparing the number and complexity of odontogenic infections presenting to an acute general hospital in two periods, as follows: Group A (January 2008 to March 2010) versus Group B (April 2010 to December 2011). The background to the study is 'An alteration in patient access to primary dental care instituted by the Department of Health in April 2010'. a) to identify any alteration in the pattern and complexity of patients' presentation with odontogenic infections following recent changes in access to treatment via the Dental Treatment Services Scheme (DTSS) and the Dental Treatment Benefit Scheme (DTBS) in April 2010; and, b) to evaluate the management of severe odontogenic infections. Data was collated by a combination of a comprehensive chart review and electronic patient record analysis based on the primary discharge diagnosis as recorded in the Hospital In-Patient Enquiry (HIPE) system. Fifty patients were admitted to the National Maxillofacial Unit, St James's Hospital, under the oral and maxillofacial service over a four-year period, with an odontogenic infection as the primary diagnosis. There was an increased number of patients presenting with odontogenic infections during Group B of the study. These patients showed an increased complexity and severity of infection. Although there was an upward trend in the numbers and complexity of infections, this trending did not reach statistical significance. The primary cause of infection was dental caries in all patients. Dental caries is a preventable and treatable disease. Increased resources should be made available to support access to dental care, and thereby lessen the potential for the morbidity and mortality associated with serious odontogenic infections. The study at present continues as a prospective study.

  11. Quantitative Comparison of Abundance Structures of Generalized Communities: From B-Cell Receptor Repertoires to Microbiomes.

    Directory of Open Access Journals (Sweden)

    Mohammadkarim Saeedghalati

    2017-01-01

    Full Text Available The community, the assemblage of organisms co-existing in a given space and time, has the potential to become one of the unifying concepts of biology, especially with the advent of high-throughput sequencing experiments that reveal genetic diversity exhaustively. In this spirit we show that a tool from community ecology, the Rank Abundance Distribution (RAD, can be turned by the new MaxRank normalization method into a generic, expressive descriptor for quantitative comparison of communities in many areas of biology. To illustrate the versatility of the method, we analyze RADs from various generalized communities, i.e. assemblages of genetically diverse cells or organisms, including human B cells, gut microbiomes under antibiotic treatment and of different ages and countries of origin, and other human and environmental microbial communities. We show that normalized RADs enable novel quantitative approaches that help to understand structures and dynamics of complex generalized communities.

  12. Interest Rates with Long Memory: A Generalized Affine Term-Structure Model

    DEFF Research Database (Denmark)

    Osterrieder, Daniela

    .S. government bonds, we model the time series of the state vector by means of a co-fractional vector autoregressive model. The implication is that yields of all maturities exhibit nonstationary, yet mean-reverting, long-memory behavior of the order d ≈ 0.87. The long-run dynamics of the state vector are driven......We propose a model for the term structure of interest rates that is a generalization of the discrete-time, Gaussian, affine yield-curve model. Compared to standard affine models, our model allows for general linear dynamics in the vector of state variables. In an application to real yields of U...... forecasts that outperform several benchmark models, especially at long forecasting horizons....

  13. Altered structural and functional thalamocortical networks in secondarily generalized extratemporal lobe seizures

    Directory of Open Access Journals (Sweden)

    Syu-Jyun Peng

    2017-01-01

    Full Text Available Structural and functional abnormalities in the thalamocortical network in primary generalized epilepsies or mesial temporal lobe epilepsy have recently been identified by voxel-wise analyses of neuroimaging. However, evidence is needed regarding the profiles of the thalamocortical network in patients with secondarily generalized seizures from focal neocortical sources. We used high-resolution T1-weighted, diffusion-tensor and resting-state functional MR imaging (rs-fMRI to examine 16 patients with secondarily generalized extratemporal lobe seizures and 16 healthy controls. All the patients were medically effective and MRI-negative. Using whole brain voxel-based morphometry (VBM to compare the patients with the normal controls, we observed significantly decreased gray matter (GM density in the thalamus and 3 frontal gyri and significantly reduced white matter (WM fractional anisotropy (FA in the bilateral anterior corona radiata of the patients. Alterations in the thalamocortical functional connectivity with different cortices were identified by the rs-fMRI analysis seeding of the whole thalamus. The prefrontal gyri with the greatest functional connectivity were also traced by seeding a sub-thalamic region that is demarcated in an atlas, in which the thalamic parcellation is based on the WM connectivity to the cortices. This sub-thalamic region anatomically contains the mediodorsal thalamic nucleus where, concordantly, there was a significant decrease in thalamic GM density in the VBM study. In contrast to the negative correlation between the disease duration and reduced thalamic densities and subcortical FA values, the strength of the functional thalamocortical connectivity had a paradoxical correlation. Our results conclusively indicate that generalized seizures with a focal cortical source are associated with structural and functional alterations in the thalamocortical network.

  14. On the structure of generalized monopole solutions in gauge-theories

    International Nuclear Information System (INIS)

    Horvath, Z.; Palla, L.

    1976-01-01

    A method is presented for constructing generalized 't Hooft monopole solutions in a gauge theory with an arbitrary gauge group. Restrictions arising from the condition of finite energy are derived. The radial oscillation of the solution is discussed. Using this method all the SU(3) solutions known in the literature are reproduced. Finite energy monopoles possessing magnetic charge in the range g 0 0 0 are found in SU(N) gauge theories. Different charge quantization conditions are analyzed to understand the structure of the solutions. (Auth.)

  15. The Hodge structure of semiample hypersurfaces and a generalization of the monomial-divisor mirror map

    OpenAIRE

    Mavlyutov, Anvar R.

    2000-01-01

    We solved the long-standing problem of describing the cohomology ring of semiample hypersurfaces in complete simplicial toric varieties. Also, the monomial-divisor mirror map is generalized to a map between the whole Picard group and the space of infinitesimal deformations for a mirror pair of Calabi-Yau hypersurfaces. This map is compatible with certain vanishing limiting products of the subrings of the chiral rings, on which the ring structure is related to a product of the roots of $A$-typ...

  16. Generalized Pattern Search methods for a class of nonsmooth optimization problems with structure

    Science.gov (United States)

    Bogani, C.; Gasparo, M. G.; Papini, A.

    2009-07-01

    We propose a Generalized Pattern Search (GPS) method to solve a class of nonsmooth minimization problems, where the set of nondifferentiability is included in the union of known hyperplanes and, therefore, is highly structured. Both unconstrained and linearly constrained problems are considered. At each iteration the set of poll directions is enforced to conform to the geometry of both the nondifferentiability set and the boundary of the feasible region, near the current iterate. This is the key issue to guarantee the convergence of certain subsequences of iterates to points which satisfy first-order optimality conditions. Numerical experiments on some classical problems validate the method.

  17. General structure of democratic mass matrix of quark sector in E{sub 6} model

    Energy Technology Data Exchange (ETDEWEB)

    Ciftci, R., E-mail: rciftci@cern.ch [Ankara (Turkey); Çiftci, A. K., E-mail: abbas.kenan.ciftci@cern.ch [Ankara University, Ankara (Turkey)

    2016-03-25

    An extension of the Standard Model (SM) fermion sector, which is inspired by the E{sub 6} Grand Unified Theory (GUT) model, might be a good candidate to explain a number of unanswered questions in SM. Existence of the isosinglet quarks might explain great mass difference of bottom and top quarks. Also, democracy on mass matrix elements is a natural approach in SM. In this study, we have given general structure of Democratic Mass Matrix (DMM) of quark sector in E6 model.

  18. General structure of the GRAND program for analysis of the data from a neutrino detector

    International Nuclear Information System (INIS)

    Zhigunov, V.P.; Kulikov, V.A.; Mukhin, S.A.; Naumov, V.L.; Platonov, V.G.; Spiridonov, A.A.

    1985-01-01

    The general structure of the GRAND (Global Result Analysis for Neutrino Detector) program used for geometrical and kinematic reconstruction of events recorded by a neutrino detector is considered. The detector consists of a calorimeter-target, a shower electron and γ detector and a magnetic spectrometer. While developing the GRAND program the multivariance (different types of the computers used), availability of various algorithms for solving the same problem, solution of separate particlular problems within the frames of one program are taken into account. The KERNLIB library and the HBOOK, ZBOOK, EPIO and FFREAD subroutine packages are used while creating the program as basic libraries

  19. Application of the generalized multi structural (GMS) wave function to photoelectron spectra and electron scattering processes

    International Nuclear Information System (INIS)

    Nascimento, M.A.C. do

    1992-01-01

    A Generalized Multi Structural (GMS) wave function is presented which combines the advantages of the SCF-MO and VB models, preserving the classical chemical structures but optimizing the orbitals in a self-consistent way. This wave function is particularly suitable to treat situations where the description of the molecular state requires localized wave functions. It also provides a very convenient way of treating the electron correlation problem, avoiding large CI expansions. The final wave functions are much more compact and easier to interpret than the ones obtained by the conventional methods, using orthogonal orbitals. Applications of the GMS wave function to the study of the photoelectron spectra of the trans-glyoxal molecule and to electron impact excitation processes in the nitrogen molecule are presented as an illustration of the method. (author)

  20. General approach to understanding the electronic structure of graphene on metals

    International Nuclear Information System (INIS)

    Voloshina, E N; Dedkov, Yu S

    2014-01-01

    This manuscript presents the general approach to the understanding of the connection between bonding mechanism and electronic structure of graphene on metals. To demonstrate its validity, two limiting cases of ‘weakly’ and ‘strongly’ bonded graphene on Al(111) and Ni(111) are considered, where the Dirac cone is preserved or fully destroyed, respectively. Furthermore, the electronic structure, i.e. doping level, hybridization effects, as well as a gap formation at the Dirac point of the intermediate system, graphene/Cu(111), is fully understood in the framework of the proposed approach. This work summarises the long-term debates regarding connection of the bonding strength and the valence band modification in the graphene/metal systems and paves a way for the effective control of the electronic states of graphene in the vicinity of the Fermi level. (paper)

  1. Material properties requirements for LMFBR structural design: General considerations and data needs

    Energy Technology Data Exchange (ETDEWEB)

    Pugh, C E [Oak Ridge National Laboratory, Oak Ridge, TN (United States); Purdy, C M [U.S. Energy Research and Development Administration (United States)

    1977-07-01

    A statement is given of material properties information needed in connection with the structural design technology for liquid-metal fast breeder reactor (LMFBR) primary circuit components. Implementation of current analysis methods and criteria is considered with an emphasis on data and data correlations for performing elastic-plastic and creep analyses, for establishing allowable stress limits, and for computing creep-fatigue damage. Further development of the technology is discussed in relation to properties information. Emphasis is placed on improved constitutive equations for representing inelastic material behavior, on procedures for treating time-dependent fatigue, and on criteria for creep rupture. The properties are generally discussed without regard to specific alloys, since most categories of information are needed for each major structural material. Some sample experimental results are given for type 304 stainless steel and 2 1/4 Cr-1 Mo steel. (author)

  2. Material properties requirements for LMFBR structural design: general considerations and data needs

    International Nuclear Information System (INIS)

    Pugh, C.E.; Purdy, C.M.

    1977-01-01

    A statement is given of material properties information needed in connection with the structural design technology for liquid-metal fast breeder reactor (LMFBR) primary circuit components. Implementation of current analysis methods and criteria is considered with an emphasis on data and data correlations for performing elastic-plastic and creep analyses, for establishing allowable stress limits, and for computing creep-fatigue damage. Further development of the technology is discussed in relation to properties information. Emphasis is placed on improved constitutive equations for representing inelastic material behavior, on procedures for treating time-dependent fatigue, and on criteria for creep rupture. The properties are generally discussed without regard to specific alloys, since most categories of information are needed for each major structural material. Some sample experimental results are given for type 304 stainless steel and 2 1 / 4 Cr-1 Mo steel

  3. Generalized linear longitudinal mixed models with linear covariance structure and multiplicative random effects

    DEFF Research Database (Denmark)

    Holst, René; Jørgensen, Bent

    2015-01-01

    The paper proposes a versatile class of multiplicative generalized linear longitudinal mixed models (GLLMM) with additive dispersion components, based on explicit modelling of the covariance structure. The class incorporates a longitudinal structure into the random effects models and retains...... a marginal as well as a conditional interpretation. The estimation procedure is based on a computationally efficient quasi-score method for the regression parameters combined with a REML-like bias-corrected Pearson estimating function for the dispersion and correlation parameters. This avoids...... the multidimensional integral of the conventional GLMM likelihood and allows an extension of the robust empirical sandwich estimator for use with both association and regression parameters. The method is applied to a set of otholit data, used for age determination of fish....

  4. A general centroid determination methodology, with application to multilayer dielectric structures and thermally stimulated current measurements

    International Nuclear Information System (INIS)

    Miller, S.L.; Fleetwood, D.M.; McWhorter, P.J.; Reber, R.A. Jr.; Murray, J.R.

    1993-01-01

    A general methodology is developed to experimentally characterize the spatial distribution of occupied traps in dielectric films on a semiconductor. The effects of parasitics such as leakage, charge transport through more than one interface, and interface trap charge are quantitatively addressed. Charge transport with contributions from multiple charge species is rigorously treated. The methodology is independent of the charge transport mechanism(s), and is directly applicable to multilayer dielectric structures. The centroid capacitance, rather than the centroid itself, is introduced as the fundamental quantity that permits the generic analysis of multilayer structures. In particular, the form of many equations describing stacked dielectric structures becomes independent of the number of layers comprising the stack if they are expressed in terms of the centroid capacitance and/or the flatband voltage. The experimental methodology is illustrated with an application using thermally stimulated current (TSC) measurements. The centroid of changes (via thermal emission) in the amount of trapped charge was determined for two different samples of a triple-layer dielectric structure. A direct consequence of the TSC analyses is the rigorous proof that changes in interface trap charge can contribute, though typically not significantly, to thermally stimulated current

  5. Accessibility and sensory experiences

    DEFF Research Database (Denmark)

    Ryhl, Camilla

    2010-01-01

    and accessibility. Sensory accessibility accommodates aspects of a sensory disability and describes architectural design requirements needed to ensure access to architectural experiences. In the context of architecture accessibility has become a design concept of its own. It is generally described as ensuring...... physical access to the built environment by accommodating physical disabilities. While the existing concept of accessibility ensures the physical access of everyone to a given space, sensory accessibility ensures the choice of everyone to stay and be able to participate and experience....

  6. Sectoral Plan 'Deep Geological Disposal', Stage 2. Proposed site areas for the surface facilities of the deep geological repositories as well as for their access infrastructure. General report

    International Nuclear Information System (INIS)

    2011-12-01

    In line with the provisions of the nuclear energy legislation, the sites for deep geological disposal of Swiss radioactive waste are selected in a three-stage Sectoral Plan process (Sectoral Plan for Deep Geological Disposal). The disposal sites are specified in Stage 3 of the selection process with the granting of a general licence in accordance with the Nuclear Energy Act. The first stage of the process was completed on 30 th November 2011, with the decision of the Federal Council to incorporate the six geological siting regions proposed by the National Cooperative for the Disposal of Radioactive Waste (NAGRA) into the Sectoral Plan for Deep Geological Disposal, for further evaluation in Stage 2. The decision also specifies the planning perimeters within which the surface facilities and shaft locations for the repositories will be constructed. In the second stage of the process, at least two geological siting regions each will be specified for the repository for low- and intermediate-level waste (L/ILW) and for the high-level waste (HLW) repository and these will undergo detailed geological investigation in Stage 3. For each of these potential siting regions, at least one location for the surface facility and a corridor for the access infrastructure will also be specified. NAGRA is responsible, at the beginning of Stage 2, for submitting proposals for potential locations for the surface facilities and their access infrastructure to the Federal Office of Energy (SFOE); these are then considered by the regional participation bodies in the siting regions. The present report and its annexes volume document these proposals. In Stage 2, under the lead of the SFOE, socio-economic-ecological studies will also be carried out to investigate the impact of a repository project on the environment, economy and society. The present reports also contain the input data to be provided by NAGRA for the generic (site-independent) part of these impact studies. A meaningful discussion

  7. Feasibility studies for accessing nucleon structure observables with the PANDA experiment at the future FAIR facility

    International Nuclear Information System (INIS)

    Mora Espi, Maria Carmen

    2012-10-01

    the direct extraction of the electromagnetic form factors. However, the total cross section can still be measured and an extraction of the electromagnetic form factors is possible considering certain assumptions on the ratio between the electric and magnetic contributions. The transition distribution amplitudes are new non-perturbative objects describing the transition between a baryon and a meson. They are accessible in hard exclusive processes like anti pp→e + e - π 0 . The study of this process with PANDA will test the transition distribution amplitudes approach. This work includes a feasibility study for measuring this channel with PANDA. The main background reaction is here anti pp→π + π - π 0 . A background suppression factor of 10 8 has been achieved while keeping a signal efficiency above 20 %. Part of this work has been published in the European Physics Journal A 44, 373-384 (2010).

  8. Feasibility studies for accessing nucleon structure observables with the PANDA experiment at the future FAIR facility

    Energy Technology Data Exchange (ETDEWEB)

    Mora Espi, Maria Carmen

    2012-10-15

    angular distribution. Above this s limit, the low cross section will not allow the direct extraction of the electromagnetic form factors. However, the total cross section can still be measured and an extraction of the electromagnetic form factors is possible considering certain assumptions on the ratio between the electric and magnetic contributions. The transition distribution amplitudes are new non-perturbative objects describing the transition between a baryon and a meson. They are accessible in hard exclusive processes like anti pp{yields}e{sup +}e{sup -}{pi}{sup 0}. The study of this process with PANDA will test the transition distribution amplitudes approach. This work includes a feasibility study for measuring this channel with PANDA. The main background reaction is here anti pp{yields}{pi}{sup +}{pi}{sup -}{pi}{sup 0}. A background suppression factor of 10{sup 8} has been achieved while keeping a signal efficiency above 20 %. Part of this work has been published in the European Physics Journal A 44, 373-384 (2010).

  9. Objective Sleep Structure and Cardiovascular Risk Factors in the General Population: The HypnoLaus Study

    Science.gov (United States)

    Haba-Rubio, José; Marques-Vidal, Pedro; Andries, Daniela; Tobback, Nadia; Preisig, Martin; Vollenweider, Peter; Waeber, Gérard; Luca, Gianina; Tafti, Mehdi; Heinzer, Raphaël

    2015-01-01

    Study Objectives: To evaluate the association between objective sleep measures and metabolic syndrome (MS), hypertension, diabetes, and obesity. Design: Cross-sectional study. Setting: General population sample. Participants: There were 2,162 patients (51.2% women, mean age 58.4 ± 11.1). Interventions: Patients were evaluated for hypertension, diabetes, overweight/obesity, and MS, and underwent a full polysomnography (PSG). Measurements and Results: PSG measured variables included: total sleep time (TST), percentage and time spent in slow wave sleep (SWS) and in rapid eye movement (REM) sleep, sleep efficiency and arousal index (ArI). In univariate analyses, MS was associated with decreased TST, SWS, REM sleep, and sleep efficiency, and increased ArI. After adjustment for age, sex, smoking, alcohol, physical activity, drugs that affect sleep and depression, the ArI remained significantly higher, but the difference disappeared in patients without significant sleep disordered breathing (SDB). Differences in sleep structure were also found according to the presence or absence of hypertension, diabetes, and overweight/obesity in univariate analysis. However, these differences were attenuated after multivariate adjustment and after excluding subjects with significant SDB. Conclusions: In this population-based sample we found significant associations between sleep structure and metabolic syndrome (MS), hypertension, diabetes, and obesity. However, these associations were cancelled after multivariate adjustment. We conclude that normal variations in sleep contribute little if any to MS and associated disorders. Citation: Haba-Rubio J, Marques-Vidal P, Andries D, Tobback N, Preisig M, Vollenweider P, Waeber G, Luca G, Tafti M, Heinzer R. Objective sleep structure and cardiovascular risk factors in the general population: the HypnoLaus study. SLEEP 2015;38(3):391–400. PMID:25325467

  10. A 1T Dynamic Random Access Memory Cell Based on Gated Thyristor with Surrounding Gate Structure for High Scalability.

    Science.gov (United States)

    Kim, Hyungjin; Kim, Sihyun; Kim, Hyun-Min; Lee, Kitae; Kim, Sangwan; Pak, Byung-Gook

    2018-09-01

    In this study, we investigate a one-transistor (1T) dynamic random access memory (DRAM) cell based on a gated-thyristor device utilizing voltage-driven bistability to enable high-speed operations. The structural feature of the surrounding gate using a sidewall provides high scalability with regard to constructing an array architecture of the proposed devices. In addition, the operation mechanism, I-V characteristics, DRAM operations, and bias dependence are analyzed using a commercial device simulator. Unlike conventional 1T DRAM cells utilizing the floating body effect, excess carriers which are required to be stored to make two different states are not generated but injected from the n+ cathode region, giving the device high-speed operation capabilities. The findings here indicate that the proposed DRAM cell offers distinct advantages in terms of scalability and high-speed operations.

  11. A novel multiplexer-based structure for random access memory cell in quantum-dot cellular automata

    Science.gov (United States)

    Naji Asfestani, Mazaher; Rasouli Heikalabad, Saeed

    2017-09-01

    Quantum-dot cellular automata (QCA) is a new technology in scale of nano and perfect replacement for CMOS circuits in the future. Memory is one of the basic components in any digital system, so designing the random access memory (RAM) with high speed and optimal in QCA is important. In this paper, by employing the structure of multiplexer, a novel RAM cell architecture is proposed. The proposed architecture is implemented without the coplanar crossover approach. The proposed architecture is simulated using the QCADesigner version 2.0.3 and QCAPro. The simulation results demonstrate that the proposed QCA RAM architecture has the best performance in terms of delay, circuit complexity, area, cell count and energy consumption in comparison with other QCA RAM architectures.

  12. Power structure among the actors of financial support to the poor to access health services: Social network analysis approach.

    Science.gov (United States)

    Etemadi, Manal; Gorji, Hasan Abolghasem; Kangarani, Hannaneh Mohammadi; Ashtarian, Kioomars

    2017-12-01

    The extent of universal health coverage in terms of financial protection is worrisome in Iran. There are challenges in health policies to guarantee financial accessibility to health services, especially for poor people. Various institutions offer support to ensure that the poor have financial access to health services. The aim of this study is to investigate the relationship network among the institutions active in this field. This study is a policy document analysis. It evaluates the country's legal documents in the field of financial support to the poor for healthcare after the Islamic Revolution in Iran. The researchers looked for the documents on the related websites and referred to the related organizations. The social network analysis approach was chosen for the analysis of the documents. Block-modelling and multi-dimensional scaling (MDS) was used to determine the network structures. The UCINET software was employed to analyse the data. Most the main actors of this network are chosen from the government budget. There is no legal communication and cooperation among some of the actors because of their improper position in the network. Seven blocks have been clustered by CONCOR in terms of the actor's degree of similarity. The social distance among the actors of the seven blocks is very short. Power distribution in the field of financial support to the poor has a fragmented structure; however, it is mainly run by a dominant block consisting of The Supreme Council of Welfare and Social Security, Health Insurance Organization, and the Ministry of Health and Medical Education. The financial support for the poor network involves multiple actors. This variety has created a series of confusions in terms of the type, level, and scope of responsibilities among the actors. The weak presence legislative and regulatory institutions and also non-governmental institutions are the main weak points of this network. Copyright © 2017 Elsevier Ltd. All rights reserved.

  13. General observation of the memory effect in metal-insulator-ITO structures due to indium diffusion

    International Nuclear Information System (INIS)

    Wu, Xiaojing; Xu, Huihua; Zhao, Ni; Wang, Yu; Rogach, Andrey L; Shen, Yingzhong

    2015-01-01

    Resistive random access memory (RRAM) devices based on metal oxides, organic molecules and inorganic nanocrystals (NCs) have been studied extensively in recent years. Different memory switching mechanisms have been proposed and shown to be closely related to the device architectures. In this work, we demonstrate that the use of an ITO/active layer/InGa structure can yield nonvolatile resistive memory behavior in a variety of active materials, including polymers, organic small molecules, and colloidal NCs. Through the electrode material and thickness-dependent study, we show that the ON state of the devices is associated with filamentary conduction induced by indium diffusion from the ITO electrode, occurring mostly within around 40–50 nm from the ITO/active layer interface. A negative differential resistance (NDR) regime is observed during transition from the ON to OFF state, and is explained by the space charge limited current (SCLC) effect due to hole injection at the ITO/active layer interface. Our study reveals the impact of indium diffusion at the ITO/active layer interface, an important factor that should be taken into consideration when designing thin printed RRAM devices. (paper)

  14. Measurement of Exclusive $π^0$ Electroproduction Structure Functions and their Relationship to Transverse Generalized Parton Distributions

    Energy Technology Data Exchange (ETDEWEB)

    Bedlinskiy, Ivan; Niccolai, Silvia; Stoler, Paul; Adhikari, Krishna; Aghasyan, Mher; Amaryan, Moskov; Anghinolfi, Marco; Avagyan, Harutyun; Baghdasaryan, Hovhannes; Ball, Jacques; Baltzell, Nathan; Battaglieri, Marco; Bennett, Robert; Biselli, Angela; Bookwalter, Craig; Boyarinov, Sergey; Briscoe, William; Brooks, Williams; Burkert, Volker; Carman, Daniel; Celentano, Andrea; Chandavar, Shloka; Charles, Gabriel; Contalbrigo, Marco; Crede, Volker; D& #x27; Angelo, Annalisa; Daniel, Aji; Dashyan, Natalya; De Vita, Raffaella; De Sanctis, Enzo; Deur, Alexandre; Djalali, Chaden; Doughty, David; Dupre, Raphael; Egiyan, Hovanes; El Alaoui, Ahmed; Elfassi, Lamiaa; Elouadrhiri, Latifa; Eugenio, Paul; Fedotov, Gleb; Fegan, Stuart; Fleming, Jamie; Forest, Tony; Garcon, Michel; Gevorgyan, Nerses; Giovanetti, Kevin; Girod, Francoi-Xavier; Gohn, Wesley; Gothe, Ralf; Graham, Lewis; Griffioen, Keith; Guegan, Baptiste; Guidal, Michel; Guo, Lei; Hafidi, Kawtar; Hakobyan, Hayk; Hanretty, Charles; Heddle, David; Hicks, Kenneth; Holtrop, Maurik; Ilieva, Yordanka; Ireland, David; Ishkhanov, Boris; Isupov, Evgeny; Jo, Hyon-Suk; Joo, Kyungseon; Keller, Dustin; Khanddaker, Mahbubul; Khertarpal, Puneet; Kim, Andrey; Kim, Wooyoung; Klein, Franz; Koirala, Suman; Kubarovsky, A; Kuhn, Sebastian; Kuleshov, Sergey; Kvaltine, Nicholas; Livingston, Kenneth; Lu, Haiyun; MacGregor, Ian; Mao, Yuqing; Markov, Nikolai; Martinez, D; Mayer, Michael; McKinnon, Bryan; Meyer, Curtis; Mineeva, Taisiya; Mirazita, Marco; Mokeev, Viktor; Moutarde, Herve; Munevar Espitia, Edwin; Munoz Camacho, Carlos; Nadel-Turonski, Pawel; Niculescu, Gabriel; Niculescu, Maria-Ioana; Osipenko, Mikhail; Ostrovidov, Alexander; Pappalardo, Luciano; Permuzyan, Rafayel; Park, Kijun; Park, Sungkyun; Pasyuk, Eugene; Pereira, Sergio; Phelps, Evan; Pisano, Silvia; Pogorelko, Oleg; Pozdnyakov, Sergey; Price, John; Procureur, Sebastien; Prok, Yelena; Protopopescu, Dan; Puckett, Andrew; Raue, Brian; Ricco, Giovanni; Rimal, Dipak; Ripani, Marco; Rosner, Guenther; Rossi, Patrizia; Sabatie, Franck; Saini, Mukesh; Salgado, Carlos; Saylor, Nicholas; Schott, Diane; Schumacher, Reinhard; Seder, Erin; Seraydaryan, Heghine; Sharabian, Youri; Smith, Gregory; Sober, Daniel; Sokhan, Daria; Stepanyan, Samuel; Strauch, Steffen; Taiuti, Mauro; Tang, Wei; Taylor, Charles; Tian, Ye; Tkachenko, Svyatoslav; Ungaro, Maurizio; Vineyard, Michael; Vlasov, Alexander; Voskanyan, Hakob; Voutier, Eric; Walford, Natalie; Watts, Daniel; Weinstein, Lawrence; Weygan, Dennis; Wood, Michael; Zachariou, Nicholas; Zhang, Jixie; Zhao, Zhiwen

    2012-09-01

    Exclusive $\\pi^0$ electroproduction at a beam energy of 5.75 GeV has been measured with the Jefferson Lab CLAS spectrometer. Differential cross sections were measured at more than 1800 kinematic values in $Q^2$, $x_B$, $t$, and $\\phi_\\pi$, in the $Q^2$ range from 1.0 to 4.6 GeV$^2$,\\ $-t$ up to 2 GeV$^2$, and $x_B$ from 0.1 to 0.58. Structure functions $\\sigma_T +\\epsilon \\sigma_L, \\sigma_{TT}$ and $\\sigma_{LT}$ were extracted as functions of $t$ for each of 17 combinations of $Q^2$ and $x_B$. The data were compared directly with two handbag-based calculations including both longitudinal and transversity GPDs. Inclusion of only longitudinal GPDs very strongly underestimates $\\sigma_T +\\epsilon \\sigma_L$ and fails to account for $\\sigma_{TT}$ and $\\sigma_{LT}$, while inclusion of transversity GPDs brings the calculations into substantially better agreement with the data. There is very strong sensitivity to the relative contributions of nucleon helicity flip and helicity non-flip processes. The results confirm that exclusive $\\pi^0$ electroproduction offers direct experimental access to the transversity GPDs.

  15. Rat Strain Ontology: structured controlled vocabulary designed to facilitate access to strain data at RGD.

    Science.gov (United States)

    Nigam, Rajni; Munzenmaier, Diane H; Worthey, Elizabeth A; Dwinell, Melinda R; Shimoyama, Mary; Jacob, Howard J

    2013-11-22

    The Rat Genome Database (RGD) ( http://rgd.mcw.edu/) is the premier site for comprehensive data on the different strains of the laboratory rat (Rattus norvegicus). The strain data are collected from various publications, direct submissions from individual researchers, and rat providers worldwide. Rat strain, substrain designation and nomenclature follow the Guidelines for Nomenclature of Mouse and Rat Strains, instituted by the International Committee on Standardized Genetic Nomenclature for Mice. While symbols and names aid in identifying strains correctly, the flat nature of this information prohibits easy search and retrieval, as well as other data mining functions. In order to improve these functionalities, particularly in ontology-based tools, the Rat Strain Ontology (RS) was developed. The Rat Strain Ontology (RS) reflects the breeding history, parental background, and genetic manipulation of rat strains. This controlled vocabulary organizes strains by type: inbred, outbred, chromosome altered, congenic, mutant and so on. In addition, under the chromosome altered category, strains are organized by chromosome, and further by type of manipulations, such as mutant or congenic. This allows users to easily retrieve strains of interest with modifications in specific genomic regions. The ontology was developed using the Open Biological and Biomedical Ontology (OBO) file format, and is organized on the Directed Acyclic Graph (DAG) structure. Rat Strain Ontology IDs are included as part of the strain report (RS: ######). As rat researchers are often unaware of the number of substrains or altered strains within a breeding line, this vocabulary now provides an easy way to retrieve all substrains and accompanying information. Its usefulness is particularly evident in tools such as the PhenoMiner at RGD, where users can now easily retrieve phenotype measurement data for related strains, strains with similar backgrounds or those with similar introgressed regions. This

  16. Access French

    CERN Document Server

    Grosz, Bernard

    2014-01-01

    Access is the major new language series designed with the needs of today's generation of students firmly in mind. Whether learning for leisure or business purposes or working towards a curriculum qualification, Access French is specially designed for adults of all ages and gives students a thorough grounding in all the skills required to understand, speak, read and write contemporary French from scratch. The coursebook consists of 10 units covering different topic areas, each of which includes Language Focus panels explaining the structures covered and a comprehensive glossary. Learning tips

  17. Utilisation of a direct access echocardiography service by general practitioners in a remote and rural area--distance and rurality are not barriers to referral.

    Science.gov (United States)

    Choo, Wai K; McGeary, Katie; Farman, Colin; Greyling, Andre; Cross, Stephen J; Leslie, Stephen J

    2014-01-01

    This study aimed to examine whether general practitioner (GP) practice locations in remote and rural areas affected the pattern of direct access echocardiography referral and to assess any variations in echocardiographic findings. All referrals made by all GP practices in the Scottish Highlands over a 36-month period were analysed. Referral patterns were examined according to distance and rurality based on the Scottish Government's Urban-Rural Classification. Reasons for referral and cardiac abnormality detection rates were also examined. In total, 1188 referrals were made from 49 different GP practices; range of referral rates was 0.3-20.1 per 1000 population with a mean of 6.5 referrals per 1000 population. Referral rates were not significantly different between urban and rural practices after correction for population size. There was no correlation between the referral rates and the distance from the centre (r2=0.004, p=0.65). The most common reason for referral was the presence of new murmur (46%). The most common presenting symptom was breathlessness (44%). Overall, 28% of studies had significant abnormal findings requiring direct input from a cardiologist. There was no clear relationship between referral rates and cardiac abnormality detection rates (r2=0.07, p=0.37). The average cardiac abnormality detection rate was 56%, (range 52-60%), with no variation based on rurality (p=0.891). In this cohort, rurality and distance were not barriers to an equitable direct access echocardiography service. Cardiac abnormality detection rates are consistent with that of other studies.

  18. Potentials of mean force for protein structure prediction vindicated, formalized and generalized.

    Directory of Open Access Journals (Sweden)

    Thomas Hamelryck

    Full Text Available Understanding protein structure is of crucial importance in science, medicine and biotechnology. For about two decades, knowledge-based potentials based on pairwise distances--so-called "potentials of mean force" (PMFs--have been center stage in the prediction and design of protein structure and the simulation of protein folding. However, the validity, scope and limitations of these potentials are still vigorously debated and disputed, and the optimal choice of the reference state--a necessary component of these potentials--is an unsolved problem. PMFs are loosely justified by analogy to the reversible work theorem in statistical physics, or by a statistical argument based on a likelihood function. Both justifications are insightful but leave many questions unanswered. Here, we show for the first time that PMFs can be seen as approximations to quantities that do have a rigorous probabilistic justification: they naturally arise when probability distributions over different features of proteins need to be combined. We call these quantities "reference ratio distributions" deriving from the application of the "reference ratio method." This new view is not only of theoretical relevance but leads to many insights that are of direct practical use: the reference state is uniquely defined and does not require external physical insights; the approach can be generalized beyond pairwise distances to arbitrary features of protein structure; and it becomes clear for which purposes the use of these quantities is justified. We illustrate these insights with two applications, involving the radius of gyration and hydrogen bonding. In the latter case, we also show how the reference ratio method can be iteratively applied to sculpt an energy funnel. Our results considerably increase the understanding and scope of energy functions derived from known biomolecular structures.

  19. A general protocol for the generation of Nanobodies for structural biology

    DEFF Research Database (Denmark)

    Pardon, Els; Laeremans, Toon; Triest, Sarah

    2014-01-01

    There is growing interest in using antibodies as auxiliary tools to crystallize proteins. Here we describe a general protocol for the generation of Nanobodies to be used as crystallization chaperones for the structural investigation of diverse conformational states of flexible (membrane) proteins...... and complexes thereof. Our technology has a competitive advantage over other recombinant crystallization chaperones in that we fully exploit the natural humoral response against native antigens. Accordingly, we provide detailed protocols for the immunization with native proteins and for the selection by phage...... display of in vivo-matured Nanobodies that bind conformational epitopes of functional proteins. Three representative examples illustrate that the outlined procedures are robust, making it possible to solve by Nanobody-assisted X-ray crystallography in a time span of 6-12 months....

  20. Thresholds of surface codes on the general lattice structures suffering biased error and loss

    International Nuclear Information System (INIS)

    Tokunaga, Yuuki; Fujii, Keisuke

    2014-01-01

    A family of surface codes with general lattice structures is proposed. We can control the error tolerances against bit and phase errors asymmetrically by changing the underlying lattice geometries. The surface codes on various lattices are found to be efficient in the sense that their threshold values universally approach the quantum Gilbert-Varshamov bound. We find that the error tolerance of the surface codes depends on the connectivity of the underlying lattices; the error chains on a lattice of lower connectivity are easier to correct. On the other hand, the loss tolerance of the surface codes exhibits an opposite behavior; the logical information on a lattice of higher connectivity has more robustness against qubit loss. As a result, we come upon a fundamental trade-off between error and loss tolerances in the family of surface codes with different lattice geometries

  1. A general symplectic method for the response analysis of infinitely periodic structures subjected to random excitations

    Directory of Open Access Journals (Sweden)

    You-Wei Zhang

    Full Text Available A general symplectic method for the random response analysis of infinitely periodic structures subjected to stationary/non-stationary random excitations is developed using symplectic mathematics in conjunction with variable separation and the pseudo-excitation method (PEM. Starting from the equation of motion for a single loaded substructure, symplectic analysis is firstly used to eliminate the dependent degrees of the freedom through condensation. A Fourier expansion of the condensed equation of motion is then applied to separate the variables of time and wave number, thus enabling the necessary recurrence scheme to be developed. The random response is finally determined by implementing PEM. The proposed method is justified by comparison with results available in the literature and is then applied to a more complicated time-dependent coupled system.

  2. Thresholds of surface codes on the general lattice structures suffering biased error and loss

    Energy Technology Data Exchange (ETDEWEB)

    Tokunaga, Yuuki [NTT Secure Platform Laboratories, NTT Corporation, 3-9-11 Midori-cho, Musashino, Tokyo 180-8585, Japan and Japan Science and Technology Agency, CREST, 5 Sanban-cho, Chiyoda-ku, Tokyo 102-0075 (Japan); Fujii, Keisuke [Graduate School of Engineering Science, Osaka University, Toyonaka, Osaka 560-8531 (Japan)

    2014-12-04

    A family of surface codes with general lattice structures is proposed. We can control the error tolerances against bit and phase errors asymmetrically by changing the underlying lattice geometries. The surface codes on various lattices are found to be efficient in the sense that their threshold values universally approach the quantum Gilbert-Varshamov bound. We find that the error tolerance of the surface codes depends on the connectivity of the underlying lattices; the error chains on a lattice of lower connectivity are easier to correct. On the other hand, the loss tolerance of the surface codes exhibits an opposite behavior; the logical information on a lattice of higher connectivity has more robustness against qubit loss. As a result, we come upon a fundamental trade-off between error and loss tolerances in the family of surface codes with different lattice geometries.

  3. Galaxy bias and non-linear structure formation in general relativity

    International Nuclear Information System (INIS)

    Baldauf, Tobias; Seljak, Uroš; Senatore, Leonardo; Zaldarriaga, Matias

    2011-01-01

    Length scales probed by the large scale structure surveys are becoming closer and closer to the horizon scale. Further, it has been recently understood that non-Gaussianity in the initial conditions could show up in a scale dependence of the bias of galaxies at the largest possible distances. It is therefore important to take General Relativistic effects into account. Here we provide a General Relativistic generalization of the bias that is valid both for Gaussian and for non-Gaussian initial conditions. The collapse of objects happens on very small scales, while long-wavelength modes are always in the quasi linear regime. Around every small collapsing region, it is therefore possible to find a reference frame that is valid for arbitrary times and where the space time is almost flat: the Fermi frame. Here the Newtonian approximation is applicable and the equations of motion are the ones of the standard N-body codes. The effects of long-wavelength modes are encoded in the mapping from the cosmological frame to the local Fermi frame. At the level of the linear bias, the effect of the long-wavelength modes on the dynamics of the short scales is all encoded in the local curvature of the Universe, which allows us to define a General Relativistic generalization of the bias in the standard Newtonian setting. We show that the bias due to this effect goes to zero as the square of the ratio between the physical wavenumber and the Hubble scale for modes longer than the horizon, confirming the intuitive picture that modes longer than the horizon do not have any dynamical effect. On the other hand, the bias due to non-Gaussianities does not need to vanish for modes longer than the Hubble scale, and for non-Gaussianities of the local kind it goes to a constant. As a further application of our setup, we show that it is not necessary to perform large N-body simulations to extract information about long-wavelength modes: N-body simulations can be done on small scales and long

  4. On distributed key distribution centers and unconditionally secure proactive verifiable secret sharing schemes based on general access structure

    NARCIS (Netherlands)

    Nikov, V.S.; Nikova, S.I.; Preneel, B.; Vandewalle, J.; Menezes, A.; Sarkar, P.

    2002-01-01

    A Key Distribution Center of a network is a server enabling private communications within groups of users. A Distributed Key Distribution Center is a set of servers that jointly realizes a Key Distribution Center. In this paper we build a robust Distributed Key Distribution Center Scheme secure

  5. The p Factor: One General Psychopathology Factor in the Structure of Psychiatric Disorders?

    Science.gov (United States)

    Caspi, Avshalom; Houts, Renate M.; Belsky, Daniel W.; Goldman-Mellor, Sidra J.; Harrington, HonaLee; Israel, Salomon; Meier, Madeline H.; Ramrakha, Sandhya; Shalev, Idan; Poulton, Richie; Moffitt, Terrie E.

    2013-01-01

    Mental disorders traditionally have been viewed as distinct, episodic, and categorical conditions. This view has been challenged by evidence that many disorders are sequentially comorbid, recurrent/chronic, and exist on a continuum. Using the Dunedin Multidisciplinary Health and Development Study, we examined the structure of psychopathology, taking into account dimensionality, persistence, co-occurrence, and sequential comorbidity of mental disorders across 20 years, from adolescence to midlife. Psychiatric disorders were initially explained by three higher-order factors (Internalizing, Externalizing, and Thought Disorder) but explained even better with one General Psychopathology dimension. We have called this dimension the p factor because it conceptually parallels a familiar dimension in psychological science: the g factor of general intelligence. Higher p scores are associated with more life impairment, greater familiality, worse developmental histories, and more compromised early-life brain function. The p factor explains why it is challenging to find causes, consequences, biomarkers, and treatments with specificity to individual mental disorders. Transdiagnostic approaches may improve research. PMID:25360393

  6. The potential in general linear electrodynamics. Causal structure, propagators and quantization

    Energy Technology Data Exchange (ETDEWEB)

    Siemssen, Daniel [Department of Mathematical Methods in Physics, Faculty of Physics, University of Warsaw (Poland); Pfeifer, Christian [Institute for Theoretical Physics, Leibniz Universitaet Hannover (Germany); Center of Applied Space Technology and Microgravity (ZARM), Universitaet Bremen (Germany)

    2016-07-01

    From an axiomatic point of view, the fundamental input for a theory of electrodynamics are Maxwell's equations dF=0 (or F=dA) and dH=J, and a constitutive law H=F, which relates the field strength 2-form F and the excitation 2-form H. In this talk we consider general linear electrodynamics, the theory of electrodynamics defined by a linear constitutive law. The best known application of this theory is the effective description of electrodynamics inside (linear) media (e.g. birefringence). We analyze the classical theory of the electromagnetic potential A before we use methods familiar from mathematical quantum field theory in curved spacetimes to quantize it. Our analysis of the classical theory contains the derivation of retarded and advanced propagators, the analysis of the causal structure on the basis of the constitutive law (instead of a metric) and a discussion of the classical phase space. This classical analysis sets the stage for the construction of the quantum field algebra and quantum states, including a (generalized) microlocal spectrum condition.

  7. On the factor structure of the Rosenberg (1965) General Self-Esteem Scale.

    Science.gov (United States)

    Alessandri, Guido; Vecchione, Michele; Eisenberg, Nancy; Łaguna, Mariola

    2015-06-01

    Since its introduction, the Rosenberg General Self-Esteem Scale (RGSE, Rosenberg, 1965) has been 1 of the most widely used measures of global self-esteem. We conducted 4 studies to investigate (a) the goodness-of-fit of a bifactor model positing a general self-esteem (GSE) factor and 2 specific factors grouping positive (MFP) and negative items (MFN) and (b) different kinds of validity of the GSE, MFN, and MFP factors of the RSGE. In the first study (n = 11,028), the fit of the bifactor model was compared with those of 9 alternative models proposed in literature for the RGSE. In Study 2 (n = 357), the external validities of GSE, MFP, and MFN were evaluated using objective grade point average data and multimethod measures of prosociality, aggression, and depression. In Study 3 (n = 565), the across-rater robustness of the bifactor model was evaluated. In Study 4, measurement invariance of the RGSE was further supported across samples in 3 European countries, Serbia (n = 1,010), Poland (n = 699), and Italy (n = 707), and in the United States (n = 1,192). All in all, psychometric findings corroborate the value and the robustness of the bifactor structure and its substantive interpretation. (c) 2015 APA, all rights reserved).

  8. Recombinant protein expression for structural biology in HEK 293F suspension cells: a novel and accessible approach.

    Science.gov (United States)

    Portolano, Nicola; Watson, Peter J; Fairall, Louise; Millard, Christopher J; Milano, Charles P; Song, Yun; Cowley, Shaun M; Schwabe, John W R

    2014-10-16

    The expression and purification of large amounts of recombinant protein complexes is an essential requirement for structural biology studies. For over two decades, prokaryotic expression systems such as E. coli have dominated the scientific literature over costly and less efficient eukaryotic cell lines. Despite the clear advantage in terms of yields and costs of expressing recombinant proteins in bacteria, the absence of specific co-factors, chaperones and post-translational modifications may cause loss of function, mis-folding and can disrupt protein-protein interactions of certain eukaryotic multi-subunit complexes, surface receptors and secreted proteins. The use of mammalian cell expression systems can address these drawbacks since they provide a eukaryotic expression environment. However, low protein yields and high costs of such methods have until recently limited their use for structural biology. Here we describe a simple and accessible method for expressing and purifying milligram quantities of protein by performing transient transfections of suspension grown HEK (Human Embryonic Kidney) 293 F cells.

  9. General principles for the formation of dust self-organizing structures. Dust collective attraction and plasma crystal formation

    International Nuclear Information System (INIS)

    Tsytovich, V.N.

    2005-01-01

    It is demonstrated that a homogeneous dusty plasma is universally unstable to form structures. The effect of collective grain attraction is a basic phenomenon for the proposed new paradigm (general principles) for the plasma crystal formation

  10. Socio-political structure of Turkey in general elections since 1980 military intervention up to date (last 23 years)

    OpenAIRE

    D. Ali Arslan; Mustafa Çağlayandereli

    2006-01-01

    This study aims to analyze socio-political structure of Turkish society at the basis of the results of Turkish General elections since 1983 up to date. Documentary and historical research techniques will be employed during the study.

  11. German National Proficiency Scales in Biology: Internal Structure, Relations to General Cognitive Abilities and Verbal Skills

    Science.gov (United States)

    KÖLLER, OLAF

    2016-01-01

    ABSTRACT National and international large‐scale assessments (LSA) have a major impact on educational systems, which raises fundamental questions about the validity of the measures regarding their internal structure and their relations to relevant covariates. Given its importance, research on the validity of instruments specifically developed for LSA is still sparse, especially in science and its subdomains biology, chemistry, and physics. However, policy decisions for the improvement of educational quality based on LSA can only be helpful if valid information on students’ achievement levels is provided. In the present study, the nature of the measurement instruments based on the German Educational Standards in Biology is examined. On the basis of data from 3,165 students in Grade 10, we present dimensional analyses and report the relationship between different subdimensions of biology literacy and cognitive covariates such as general cognitive abilities and verbal skills. A theory‐driven two‐dimensional model fitted the data best. Content knowledge and scientific inquiry, two subdimensions of biology literacy, are highly correlated and show differential correlational patterns to the covariates. We argue that the underlying structure of biology should be incorporated into curricula, teacher training and future assessments. PMID:27818532

  12. Reproducing the nonlinear dynamic behavior of a structured beam with a generalized continuum model

    Science.gov (United States)

    Vila, J.; Fernández-Sáez, J.; Zaera, R.

    2018-04-01

    In this paper we study the coupled axial-transverse nonlinear vibrations of a kind of one dimensional structured solids by application of the so called Inertia Gradient Nonlinear continuum model. To show the accuracy of this axiomatic model, previously proposed by the authors, its predictions are compared with numeric results from a previously defined finite discrete chain of lumped masses and springs, for several number of particles. A continualization of the discrete model equations based on Taylor series allowed us to set equivalent values of the mechanical properties in both discrete and axiomatic continuum models. Contrary to the classical continuum model, the inertia gradient nonlinear continuum model used herein is able to capture scale effects, which arise for modes in which the wavelength is comparable to the characteristic distance of the structured solid. The main conclusion of the work is that the proposed generalized continuum model captures the scale effects in both linear and nonlinear regimes, reproducing the behavior of the 1D nonlinear discrete model adequately.

  13. Stability Results, Almost Global Generalized Beltrami Fields and Applications to Vortex Structures in the Euler Equations

    Science.gov (United States)

    Enciso, Alberto; Poyato, David; Soler, Juan

    2018-05-01

    Strong Beltrami fields, that is, vector fields in three dimensions whose curl is the product of the field itself by a constant factor, have long played a key role in fluid mechanics and magnetohydrodynamics. In particular, they are the kind of stationary solutions of the Euler equations where one has been able to show the existence of vortex structures (vortex tubes and vortex lines) of arbitrarily complicated topology. On the contrary, there are very few results about the existence of generalized Beltrami fields, that is, divergence-free fields whose curl is the field times a non-constant function. In fact, generalized Beltrami fields (which are also stationary solutions to the Euler equations) have been recently shown to be rare, in the sense that for "most" proportionality factors there are no nontrivial Beltrami fields of high enough regularity (e.g., of class {C^{6,α}}), not even locally. Our objective in this work is to show that, nevertheless, there are "many" Beltrami fields with non-constant factor, even realizing arbitrarily complicated vortex structures. This fact is relevant in the study of turbulent configurations. The core results are an "almost global" stability theorem for strong Beltrami fields, which ensures that a global strong Beltrami field with suitable decay at infinity can be perturbed to get "many" Beltrami fields with non-constant factor of arbitrarily high regularity and defined in the exterior of an arbitrarily small ball, and a "local" stability theorem for generalized Beltrami fields, which is an analogous perturbative result which is valid for any kind of Beltrami field (not just with a constant factor) but only applies to small enough domains. The proof relies on an iterative scheme of Grad-Rubin type. For this purpose, we study the Neumann problem for the inhomogeneous Beltrami equation in exterior domains via a boundary integral equation method and we obtain Hölder estimates, a sharp decay at infinity and some compactness

  14. The importance of a project level risk management methodology for EU Structural and Investment Funds accession in Romania

    Directory of Open Access Journals (Sweden)

    Nicolae Ciprian

    2017-07-01

    Full Text Available Accessing EU funds is considered to be an important development chance for all type of beneficiaries in Romania: public bodies, nongovernmental organizations and firms. The grounds for this are the amount of funds available per beneficiary and the co financing rate (for example, the investment projects for firms amounted up to 5 million Euro of EU funding at a EU co financing rate up to 70%. As the Romanian responsible authorities strive to conduct a fast and smooth process, the reality shows the funds accession is rather unpredictable and costly, both in terms of time consumption and financial resources. Lots of causes contribute to this situation, amongst which the inefficient risk management conducted, both by the state authorities responsible with the EU funds management and by the beneficiaries of funds. The effects are visible: a poor absorption rate of the EU structural and cohesion funds (79,23% at the level of January 2017 for the 2007-2013 financial period. The authors' research follows the importance that risk management should have in the process of managing and accessing EU funds. The research methodology starts from the responses that 170 people involved in managing EU funded projects within 2007-2013 financial period gave to an online questionnaire carried on in 2016. The focus was to establish if and how risk management methodologies/procedures/guidelines were used within the implementation of projects and in what measure this kind of approach should be compulsory or optional for the financial period 2014-2020. The research methodology further implied the analysis of key issues for projects financing such as: feasibility and opportunity determination, budgeting, projects' evaluation, etc. The main finding of the research is that applicants and beneficiaries need to implement project level risk management methodologies. Based on this, the authors propose a guideline for drafting project level risk management methodologies, that

  15. Barriers and Opportunities in Consent and Access Procedures in Low- and Middle-Income Country Biobanks: Meeting Notes from the BCNet Training and General Assembly.

    Science.gov (United States)

    Zawati, Ma'n H; Tassé, Anne Marie; Mendy, Maimuna; Caboux, Elodie; Lang, Michael

    2018-04-18

    As biobanking research in low- and middle-income countries (LMICs) continues to grow, novel legal and policy considerations have arisen. Also, while an expansive literature has developed around these issues, the views and concerns of individual researchers in these contexts have been less actively studied. These meeting notes aim to contribute to the growing literature on biobanking in LMICs by communicating a number of challenges and opportunities identified by biobank researchers themselves. Specifically, we describe concerns that emerge in consent and access policy domains. First, we present a review of the literature on distinct policy and legal concerns faced in LMICs, giving special attention to the general absence of practitioner perspectives. From there, we outline and discuss considerations that were raised by meeting participants at a Biobank and Cohort Building Network (BCNet) Ethical, Legal, and Social Issues training program. We conclude by proposing that the unique perspectives of biobank researchers in LMICs should be given serious attention and further research on these perspectives should be conducted.

  16. Sami-speaking municipalities and a control group's access to somatic specialist health care (SHC: a retrospective study on general practitioners’ referrals

    Directory of Open Access Journals (Sweden)

    Jan Norum

    2012-03-01

    Full Text Available Objectives: The Sami people constitute the indigenous people in northern Norway. The objective of this study was to clarify whether they have a similar supply of somatic specialist health care (SHC as others. Methods: The referrals from general practitioners (GPs in the primary health care (PHC in the administration area of the Sami language law (8 municipalities were matched with a control group of 11 municipalities. Population data was accessed from Statistics Norway and the time period 2007–2010 was analysed. The main outcome was the number of referrals per 1,000 inhabitants according to age group, gender and place of living. Results: 504,292 referrals in northern Norway were indentified and the Sami and control group constituted 23,093 and 22,541 referrals, respectively. The major findings were a similar referral ratio (RR (1.14 and 1.17 (p = 0.624 and women more commonly referred (female/male ratio 1.45 and 1.41 in both groups. GPs in both groups were loyal to their local hospital trust. Conclusion: Inhabitants in Sami-speaking municipalities in northern Norway have a similar supply of SHC services as controls. Inter-municipal variation was significant in both groups.

  17. Sami-speaking municipalities and a control group's access to somatic specialist health care (SHC): a retrospective study on general practitioners’ referrals

    Science.gov (United States)

    Norum, Jan; Nieder, Carsten

    2012-01-01

    Objectives The Sami people constitute the indigenous people in northern Norway. The objective of this study was to clarify whether they have a similar supply of somatic specialist health care (SHC) as others. Methods The referrals from general practitioners (GPs) in the primary health care (PHC) in the administration area of the Sami language law (8 municipalities) were matched with a control group of 11 municipalities. Population data was accessed from Statistics Norway and the time period 2007–2010 was analysed. The main outcome was the number of referrals per 1,000 inhabitants according to age group, gender and place of living. Results 504,292 referrals in northern Norway were indentified and the Sami and control group constituted 23,093 and 22,541 referrals, respectively. The major findings were a similar referral ratio (RR) (1.14 and 1.17) (p =0.624) and women more commonly referred (female/male ratio 1.45 and 1.41) in both groups. GPs in both groups were loyal to their local hospital trust. Conclusion Inhabitants in Sami-speaking municipalities in northern Norway have a similar supply of SHC services as controls. Inter-municipal variation was significant in both groups. PMID:22456052

  18. Sami-speaking municipalities and a control group's access to somatic specialist health care (SHC): a retrospective study on general practitioners' referrals.

    Science.gov (United States)

    Norum, Jan; Nieder, Carsten

    2012-03-19

    The Sami people constitute the indigenous people in northern Norway. The objective of this study was to clarify whether they have a similar supply of somatic specialist health care (SHC) as others. The referrals from general practitioners (GPs) in the primary health care (PHC) in the administration area of the Sami language law (8 municipalities) were matched with a control group of 11 municipalities. Population data was accessed from Statistics Norway and the time period 2007-2010 was analysed. The main outcome was the number of referrals per 1,000 inhabitants according to age group, gender and place of living. 504,292 referrals in northern Norway were indentified and the Sami and control group constituted 23,093 and 22,541 referrals, respectively. The major findings were a similar referral ratio (RR) (1.14 and 1.17) (p = 0.624) and women more commonly referred (female/male ratio 1.45 and 1.41) in both groups. GPs in both groups were loyal to their local hospital trust. Inhabitants in Sami-speaking municipalities in northern Norway have a similar supply of SHC services as controls. Inter-municipal variation was significant in both groups.

  19. Atomic Layer Deposited Oxide-Based Nanocomposite Structures with Embedded CoPtx Nanocrystals for Resistive Random Access Memory Applications.

    Science.gov (United States)

    Wang, Lai-Guo; Cao, Zheng-Yi; Qian, Xu; Zhu, Lin; Cui, Da-Peng; Li, Ai-Dong; Wu, Di

    2017-02-22

    Al 2 O 3 - or HfO 2 -based nanocomposite structures with embedded CoPt x nanocrystals (NCs) on TiN-coated Si substrates have been prepared by combination of thermal atomic layer deposition (ALD) and plasma-enhanced ALD for resistive random access memory (RRAM) applications. The impact of CoPt x NCs and their average size/density on the resistive switching properties has been explored. Compared to the control sample without CoPt x NCs, ALD-derived Pt/oxide/100 cycle-CoPt x NCs/TiN/SiO 2 /Si exhibits a typical bipolar, reliable, and reproducible resistive switching behavior, such as sharp distribution of RRAM parameters, smaller set/reset voltages, stable resistance ratio (≥10 2 ) of OFF/ON states, better switching endurance up to 10 4 cycles, and longer data retention over 10 5 s. The possible resistive switching mechanism based on nanocomposite structures of oxide/CoPt x NCs has been proposed. The dominant conduction mechanisms in low- and high-resistance states of oxide-based device units with embedded CoPt x NCs are Ohmic behavior and space-charge-limited current, respectively. The insertion of CoPt x NCs can effectively improve the formation of conducting filaments due to the CoPt x NC-enhanced electric field intensity. Besides excellent resistive switching performances, the nanocomposite structures also simultaneously present ferromagnetic property. This work provides a flexible pathway by combining PEALD and TALD compatible with state-of-the-art Si-based technology for multifunctional electronic devices applications containing RRAM.

  20. Reactor building with internal structure of which the movements are independent of those of the general raft and process for building these internal structures

    International Nuclear Information System (INIS)

    Hista, J.C.

    1982-01-01

    This reactor building includes a containment enclosure for the internal structures composed of a slab wedged on its periphery against the containment enclosure gusset and resting on the general raft by means of a peripheral bearing ring, a compressible layer being provided between the general raft and the slab [fr

  1. Access to treatment for substance-using women in the Republic of Georgia: socio-cultural and structural barriers.

    Science.gov (United States)

    Otiashvili, David; Kirtadze, Irma; O'Grady, Kevin E; Zule, William; Krupitsky, Evgeny; Wechsberg, Wendee M; Jones, Hendrée E

    2013-11-01

    In the Republic of Georgia, women comprise under 2% of patients in substance use treatment and to date there has been no empirical research to investigate what factors may facilitate or hinder their help-seeking behaviour or access to treatment services. This study included secondary analysis of in-depth interviews with 55 substance-using women and 34 providers of health-related services. The roles and norms of women in Georgian society were identified as major factors influencing their help-seeking behaviour. Factors that had a negative impact on use of drug treatment services included an absence of gender-specific services, judgmental attitudes of service providers, the cost of treatment and a punitive legal position in regard to substance use. Having a substance-using partner served as an additional factor inhibiting a woman's willingness to seek assistance. Within the context of orthodox Georgian society, low self-esteem, combined with severe family and social stigma play a critical role in creating barriers to the use of both general health and substance-use-treatment services for women. Education of the public, including policy makers and health care providers is urgently needed to focus on addiction as a treatable medical illness. The need for more women centred services is also critical to the provision of effective treatment for substance-using women. Copyright © 2013 Elsevier B.V. All rights reserved.

  2. Development of the relaxation-assisted 2DIR method for accessing structures of molecules and its application for studying the energy transport on a molecular level

    Science.gov (United States)

    Kasyanenko, Valeriy Mitrofanovich

    Measuring the three-dimensional structure of molecules, dynamics of structural changes, and energy transport on a molecular scale is important for many areas of natural science. Supplementing the widely used methods of x-ray diffraction, NMR, and optical spectroscopies, a two-dimensional infrared spectroscopy (2DIR) method was introduced about a decade ago. The 2DIR method measures pair-wise interactions between vibrational modes in molecules, thus acquiring molecular structural constraints such as distances between vibrating groups and the angles between their transition dipoles. The 2DIR method has been applied to a variety of molecular systems but in studying larger molecules such as proteins and peptides the method is facing challenges associated with the congestion of their vibrational spectra and delocalized character of their vibrational modes. To help extract structural information from such spectra and make efficient use of vibrational modes separated by large distances, a novel relaxation-assisted 2DIR method (RA 2DIR) has recently been proposed, which exploits the transport of excess vibrational energy from the initially excited mode. With the goal of further development of RA 2DIR, we applied it to a variety of molecular systems, including model compounds, transition-metal complexes, and isomers. The experiments revealed several novel effects which both enhance the power of RA 2DIR and bring a deeper understanding to the fundamental process of energy transport on a molecular level. We demonstrated that RA 2DIR can enhance greatly (27-fold) the cross-peak amplitude among spatially remote modes, which leads to an increase of the range of distances accessible for structural measurements by several fold. We demonstrated that the energy transport time correlates with the intermode distance. This correlation offers a new way for identifying connectivity patterns in molecules. We developed two models of energy transport in molecules. In one, a spatial overlap

  3. Introducing NMR to a General Chemistry Audience: A Structural-Based Instrumental Laboratory Relating Lewis Structures, Molecular Models, and [superscript 13]C NMR Data

    Science.gov (United States)

    Pulliam, Curtis R.; Pfeiffer, William F.; Thomas, Alyssa C.

    2015-01-01

    This paper describes a first-year general chemistry laboratory that uses NMR spectroscopy and model building to emphasize molecular shape and structure. It is appropriate for either a traditional or an atoms-first curriculum. Students learn the basis of structure and the use of NMR data through a cooperative learning hands-on laboratory…

  4. High-speed narrowband PLC - High-performance Access Powerline Communication structures in smart grid; High-Speed Narrowband PLC. Leistungsfaehige Access-Powerline-Kommunikationsstrukturen im Smart Grid

    Energy Technology Data Exchange (ETDEWEB)

    Offner, Georg [devolo AG, Aachen (Germany)

    2012-07-01

    The smart grid provides a stable operation of a decentralized power system which is fed more and more by small providers by means of solar technology and wind power technology. Furthermore, commercial and private clients profit from the smart grid, as they may capture information about their current consumption in real time or can obtain these data from the Internet. The author of the contribution under consideration presents new approaches to access powerline communications that enable efficient communication between IPv6 based household meter and network station. The contribution under consideration describes the technologies used as well as practical experiences and initial results from field tests. Here insights from the integration of G3-PLC are in the foreground.

  5. "K"-Balance Partitioning: An Exact Method with Applications to Generalized Structural Balance and Other Psychological Contexts

    Science.gov (United States)

    Brusco, Michael; Steinley, Douglas

    2010-01-01

    Structural balance theory (SBT) has maintained a venerable status in the psychological literature for more than 5 decades. One important problem pertaining to SBT is the approximation of structural or generalized balance via the partitioning of the vertices of a signed graph into "K" clusters. This "K"-balance partitioning problem also has more…

  6. General Motors and the University of Michigan smart materials and structures collaborative research laboratory

    Science.gov (United States)

    Brei, Diann; Luntz, Jonathan; Shaw, John; Johnson, Nancy L.; Browne, Alan L.; Alexander, Paul W.; Mankame, Nilesh D.

    2007-04-01

    The field of Smart Materials and Structures is evolving from high-end, one-of-a-kind products for medical, military and aerospace applications to the point of viability for mainstream affordable high volume products for automotive applications. For the automotive industry, there are significant potential benefits to be realized including reduction in vehicle mass, added functionality and design flexibility and decrease in component size and cost. To further accelerate the path from basic research and development to launched competitive products, General Motors (GM) has teamed with the College of Engineering at the University of Michigan (UM) to establish a $2.9 Million Collaborative Research Laboratory (CRL) in Smart Materials and Structures. Researchers at both GM and UM are working closely together to create leap-frog technologies which start at conceptualization and proceed all the way through demonstration and handoff to product teams, thereby bridging the traditional technology gap between industry and academia. In addition to Smart Device Technology Innovation, other thrust areas in the CRL include Smart Material Maturity with a basic research focus on overcoming material issues that form roadblocks to commercialism and Mechamatronic System Design Methodology with an applied focus on development tools (synthesis and analysis) to aid the engineer in application of smart materials to system engineering. This CRL is a global effort with partners across the nation and world from GM's Global Research Network such as HRL Laboratories in California and GM's India Science Lab in Bangalore, India. This paper provides an overview of this new CRL and gives examples of several of the projects underway.

  7. Processing/structure/property Relationships of Barium Strontium Titanate Thin Films for Dynamic Random Access Memory Application.

    Science.gov (United States)

    Peng, Cheng-Jien

    The purpose of this study is to see the application feasibility of barium strontium titanate (BST) thin films on ultra large scale integration (ULSI) dynamic random access memory (DRAM) capacitors through the understanding of the relationships among processing, structure and electrical properties. Thin films of BST were deposited by multi-ion -beam reactive sputtering (MIBERS) technique and metallo -organic decomposition (MOD) method. The processing parameters such as Ba/Sr ratio, substrate temperature, annealing temperature and time, film thickness and doping concentration were correlated with the structure and electric properties of the films. Some effects of secondary low-energy oxygen ion bombardment were also examined. Microstructures of BST thin films could be classified into two types: (a) Type I structures, with multi-grains through the film thickness, for amorphous as-grown films after high temperature annealing, and (b) columnar structure (Type II) which remained even after high temperature annealing, for well-crystallized films deposited at high substrate temperatures. Type I films showed Curie-von Schweidler response, while Type II films showed Debted type behavior. Type I behavior may be attributed to the presence of a high density of disordered grain boundaries. Two types of current -voltage characteristics could be seen in non-bombarded films depending on the chemistry of the films (doped or undoped) and substrate temperature during deposition. Only the MIBERS films doped with high donor concentration and deposited at high substrate temperature showed space-charge -limited conduction (SCLC) with discrete shallow traps embedded in trap-distributed background at high electric field. All other non-bombarded films, including MOD films, showed trap-distributed SCLC behavior with a slope of {~}7.5-10 due to the presence of grain boundaries through film thickness or traps induced by unavoidable acceptor impurities in the films. Donor-doping could

  8. Accessing the uncertainties of seismic velocity and anisotropy structure of Northern Great Plains using a transdimensional Bayesian approach

    Science.gov (United States)

    Gao, C.; Lekic, V.

    2017-12-01

    geological structures including the trans-Hudson orogen, Wyoming craton and Yellowstone hotspot. Various analyses are done to access the uncertainties of the seismic velocities and Moho depths. We also address the importance of careful data processing of receiver functions by illustrating artifacts due to unmodelled sediment reverberations.

  9. Generalized transmission line method to study the far-zone radiation of antennas under a multilayer structure

    CERN Document Server

    Wu, Xuan Hui

    2008-01-01

    This book gives a step-by-step presentation of a generalized transmission line method to study the far-zone radiation of antennas under a multilayer structure. Normally, a radiation problem requires a full wave analysis which may be time consuming. The beauty of the generalized transmission line method is that it transforms the radiation problem for a specific type of structure, say the multilayer structure excited by an antenna, into a circuit problem that can be efficiently analyzed. Using the Reciprocity Theorem and far-field approximation, the method computes the far-zone radiation due to

  10. General Dynamics Convair Division approach to structural analysis of large superconducting coils

    International Nuclear Information System (INIS)

    Baldi, R.W.

    1979-01-01

    This paper describes the overall integrated analysis approach and highlights the results obtained. Most of the procedures and techniques described were developed over the past three years. Starting in late 1976, development began on high-accuracy computer codes for electromagnetic field and force analysis. This effort resulted in completion of a family of computer programs called MAGIC (MAGnetic Integration Calculation). Included in this group of programs is a post-processor called POSTMAGIC that links MAGIC to GDSAP (General Dynamics Structural Analysis Program) by automatically transferring force data. Integrating these computer programs afforded us the capability to readily analyze several different conditions that are anticipated to occur during tokamak operation. During 1977 we initiated the development of the CONVERT program that effectively links our THERMAL ANALYZER program to GDSAP by automatically transferring temperature data. The CONVERT program allowed us the capability to readily predict thermal stresses at several different time phases during the computer-simulated cooldown and warmup cycle. This feature aided us in determining the most crucial time phases and to adjust recommended operating procedure to minimize risk. (orig.)

  11. The analytic structure of conformal blocks and the generalized Wilson-Fisher fixed points

    Energy Technology Data Exchange (ETDEWEB)

    Gliozzi, Ferdinando [Dipartimento di Fisica, Università di Torino andIstituto Nazionale di Fisica Nucleare - sezione di Torino,Via P. Giuria 1, I-10125 Torino (Italy); Guerrieri, Andrea L. [Department of Physics, Faculty of Science, Chulalongkorn University,Thanon Phayathai, Pathumwan, Bangkok 10330 (Thailand); I.N.F.N. Sezione di Roma Tor Vergata,Via della Ricerca Scientifica, I-00133 Roma (Italy); Petkou, Anastasios C. [Institute of Theoretical Physics, Aristotle University of Thessaloniki,54124 Thessaloniki (Greece); Wen, Congkao [Walter Burke Institute for Theoretical Physics, California Institute of Technology,Pasadena, CA 91125 (United States); Mani L. Bhaumik Institute for Theoretical Physics,Department of Physics and Astronomy, UCLA,Los Angeles, CA 90095 (United States)

    2017-04-11

    We describe in detail the method used in our previous work https://arxiv.org/abs/1611.10344 to study the Wilson-Fisher critical points nearby generalized free CFTs, exploiting the analytic structure of conformal blocks as functions of the conformal dimension of the exchanged operator. Our method is equivalent to the mechanism of conformal multiplet recombination set up by null states. We compute, to the first non-trivial order in the ϵ-expansion, the anomalous dimensions and the OPE coefficients of infinite classes of scalar local operators using just CFT data. We study single-scalar and O(N)-invariant theories, as well as theories with multiple deformations. When available we agree with older results, but we also produce a wealth of new ones. Unitarity and crossing symmetry are not used in our approach and we are able to apply our method to non-unitary theories as well. Some implications of our results for the study of the non-unitary theories containing partially conserved higher-spin currents are briefly mentioned.

  12. Soil-structure interaction - a general method to calculate soil impedance

    International Nuclear Information System (INIS)

    Farvacque, M.; Gantenbein, F.

    1983-01-01

    A correct analysis of the seismic response of nuclear power plant buildings needs to take into account the soil structure interaction. The most classical and simple method consists in characterizing the soil by a stiffness and a damping function for each component of the translation and rotation of the foundation. In a more exact way an impedance function of the frequency may be introduced. Literature provides data to estimate these coefficients for simple soil and foundation configurations and using linear hypothesis. This paper presents a general method to calculate soil impedances which is based on the computation of the impulsive response of the soil using an axisymmetric 2D finite element Code (INCA). The Fourier transform of this response is made in the time interval before the return of the reflected waves on the boundaries of the F.E. domain. This procedure which limits the perturbing effects of the reflections is improved by introducing absorbing boundary elements. A parametric study for homogeneous and layered soils has been carried out using this method. (orig.)

  13. Two new bivariate zero-inflated generalized Poisson distributions with a flexible correlation structure

    Directory of Open Access Journals (Sweden)

    Chi Zhang

    2015-05-01

    Full Text Available To model correlated bivariate count data with extra zero observations, this paper proposes two new bivariate zero-inflated generalized Poisson (ZIGP distributions by incorporating a multiplicative factor (or dependency parameter λ, named as Type I and Type II bivariate ZIGP distributions, respectively. The proposed distributions possess a flexible correlation structure and can be used to fit either positively or negatively correlated and either over- or under-dispersed count data, comparing to the existing models that can only fit positively correlated count data with over-dispersion. The two marginal distributions of Type I bivariate ZIGP share a common parameter of zero inflation while the two marginal distributions of Type II bivariate ZIGP have their own parameters of zero inflation, resulting in a much wider range of applications. The important distributional properties are explored and some useful statistical inference methods including maximum likelihood estimations of parameters, standard errors estimation, bootstrap confidence intervals and related testing hypotheses are developed for the two distributions. A real data are thoroughly analyzed by using the proposed distributions and statistical methods. Several simulation studies are conducted to evaluate the performance of the proposed methods.

  14. Chronic Care Team Profile: a brief tool to measure the structure and function of chronic care teams in general practice.

    Science.gov (United States)

    Proudfoot, Judith G; Bubner, Tanya; Amoroso, Cheryl; Swan, Edward; Holton, Christine; Winstanley, Julie; Beilby, Justin; Harris, Mark F

    2009-08-01

    At a time when workforce shortages in general practices are leading to greater role substitution and skill-mix diversification, and the demand on general practices for chronic disease care is increasing, the structure and function of the general practice team is taking on heightened importance. To assist general practices and the organizations supporting them to assess the effectiveness of their chronic care teamworking, we developed an interview tool, the Chronic Care Team Profile (CCTP), to measure the structure and function of teams in general practice. This paper describes its properties and potential use. An initial pool of items was derived from guidelines of best-practice for chronic disease care and performance standards for general practices. The items covered staffing, skill-mix, job descriptions and roles, training, protocols and procedures within the practice. The 41-item pool was factor analysed, retained items were measured for internal consistency and the reduced instrument's face, content and construct validity were evaluated. A three-factor solution corresponding to non-general practitioner staff roles in chronic care, administrative functions and management structures provided the best fit to the data and explained 45% of the variance in the CCTP. Further analyses suggested that the CCTP is reliable, valid and has some utility. The CCTP measures aspects of the structure and function of general practices which are independent of team processes. It is associated with the job satisfaction of general practice staff and the quality of care provided to patients with chronic illnesses. As such, the CCTP offers a simple and useful tool for general practices to assess their teamworking in chronic disease care.

  15. The laser micro-machining system for diamond anvil cell experiments and general precision machining applications at the High Pressure Collaborative Access Team.

    Science.gov (United States)

    Hrubiak, Rostislav; Sinogeikin, Stanislav; Rod, Eric; Shen, Guoyin

    2015-07-01

    We have designed and constructed a new system for micro-machining parts and sample assemblies used for diamond anvil cells and general user operations at the High Pressure Collaborative Access Team, sector 16 of the Advanced Photon Source. The new micro-machining system uses a pulsed laser of 400 ps pulse duration, ablating various materials without thermal melting, thus leaving a clean edge. With optics designed for a tight focus, the system can machine holes any size larger than 3 μm in diameter. Unlike a standard electrical discharge machining drill, the new laser system allows micro-machining of non-conductive materials such as: amorphous boron and silicon carbide gaskets, diamond, oxides, and other materials including organic materials such as polyimide films (i.e., Kapton). An important feature of the new system is the use of gas-tight or gas-flow environmental chambers which allow the laser micro-machining to be done in a controlled (e.g., inert gas) atmosphere to prevent oxidation and other chemical reactions in air sensitive materials. The gas-tight workpiece enclosure is also useful for machining materials with known health risks (e.g., beryllium). Specialized control software with a graphical interface enables micro-machining of custom 2D and 3D shapes. The laser-machining system was designed in a Class 1 laser enclosure, i.e., it includes laser safety interlocks and computer controls and allows for routine operation. Though initially designed mainly for machining of the diamond anvil cell gaskets, the laser-machining system has since found many other micro-machining applications, several of which are presented here.

  16. The laser micro-machining system for diamond anvil cell experiments and general precision machining applications at the High Pressure Collaborative Access Team

    International Nuclear Information System (INIS)

    Hrubiak, Rostislav; Sinogeikin, Stanislav; Rod, Eric; Shen, Guoyin

    2015-01-01

    We have designed and constructed a new system for micro-machining parts and sample assemblies used for diamond anvil cells and general user operations at the High Pressure Collaborative Access Team, sector 16 of the Advanced Photon Source. The new micro-machining system uses a pulsed laser of 400 ps pulse duration, ablating various materials without thermal melting, thus leaving a clean edge. With optics designed for a tight focus, the system can machine holes any size larger than 3 μm in diameter. Unlike a standard electrical discharge machining drill, the new laser system allows micro-machining of non-conductive materials such as: amorphous boron and silicon carbide gaskets, diamond, oxides, and other materials including organic materials such as polyimide films (i.e., Kapton). An important feature of the new system is the use of gas-tight or gas-flow environmental chambers which allow the laser micro-machining to be done in a controlled (e.g., inert gas) atmosphere to prevent oxidation and other chemical reactions in air sensitive materials. The gas-tight workpiece enclosure is also useful for machining materials with known health risks (e.g., beryllium). Specialized control software with a graphical interface enables micro-machining of custom 2D and 3D shapes. The laser-machining system was designed in a Class 1 laser enclosure, i.e., it includes laser safety interlocks and computer controls and allows for routine operation. Though initially designed mainly for machining of the diamond anvil cell gaskets, the laser-machining system has since found many other micro-machining applications, several of which are presented here

  17. [Schizotypal Personality Questionnaire-Brief - Likert format: Factor structure analysis in general population in France].

    Science.gov (United States)

    Ferchiou, A; Todorov, L; Lajnef, M; Baudin, G; Pignon, B; Richard, J-R; Leboyer, M; Szöke, A; Schürhoff, F

    2017-12-01

    The main objective of the study was to explore the factorial structure of the French version of the Schizotypal Personality Questionnaire-Brief (SPQ-B) in a Likert format, in a representative sample of the general population. In addition, differences in the dimensional scores of schizotypy according to gender and age were analyzed. As the study in the general population of schizotypal traits and its determinants has been recently proposed as a way toward the understanding of aetiology and pathophysiology of schizophrenia, consistent self-report tools are crucial to measure psychometric schizotypy. A shorter version of the widely used Schizotypal Personality Questionnaire (SPQ-Brief) has been extensively investigated in different countries, particularly in samples of students or clinical adolescents, and more recently, a few studies used a Likert-type scale format which allows partial endorsement of items and reduces the risk of defensive answers. A sample of 233 subjects representative of the adult population from an urban area near Paris (Créteil) was recruited using the "itinerary method". They completed the French version of the SPQ-B with a 5-point Likert-type response format (1=completely disagree; 5=completely agree). We examined the dimensional structure of the French version of the SPQ-B with a Principal Components Analysis (PCA) followed by a promax rotation. Factor selection was based on Eigenvalues over 1.0 (Kaiser's criterion), Cattell's Scree-plot test, and interpretability of the factors. Items with loadings greater than 0.4 were retained for each dimension. The internal consistency estimate of the dimensions was calculated with Cronbach's α. In order to study the influence of age and gender, we carried out a simple linear regression with the subscales as dependent variables. Our sample was composed of 131 women (mean age=52.5±18.2 years) and 102 men (mean age=53±18.1 years). SPQ-B Likert total scores ranged from 22 to 84 points (mean=43.6

  18. Differences in Power Structures Regarding Access to Natural Resources at the Village Level in Central Sulawesi (Indonesia

    Directory of Open Access Journals (Sweden)

    Jan Barkmann

    2008-01-01

    Full Text Available The mountain forests of the Indonesian province of Central Sulawesi include core areas of the global Wallacea biodiversity “hotspot”. Remote sensing data indicated that deforestation rates around Central Sulawesi’s Lore-Lindu National Park differ more strongly between villages than could be explained by differences in the individual characteristics of the village households as assessed by quantitative village censuses. This setting provided the background for a study into inter-village differences in power structures regarding access to natural resources. Our results are abstracted from 3*10 semi-structured, qualitative interviews with key informants from the leading groups of autochthonous and migrant households of three contrasting villages. In village A, nearly feudal power relationships are exerted by a group of local “first settler” families that dominate formal village leadership as well as the influential Council of Traditional Leaders (Lembaga Adat, and that restrict deforestation and land transactions. No such institutional restrictions exist in village C. Traditional power relationships are replaced by economic power based on petty capitalist type production of the international agricultural commodity cocoa. Deforestation is muchhigher in village C. In village B, traditional institutions and power structures still appear in place although land transactions are less restricted than in village A, resulting also in high deforestation rates. While contrasting problematic social effects, our study highlights the potential efficacy of traditional institutions in the regulation of access to resources. ----- Die Bergregenwälder Zentralsulawesis sind Teil des globalen Wallacea-Biodiversität-"Hotspots" und beheimaten viele endemische Tier- und Pflanzenarten. Die Entwaldung im Bereich des dortigen Lore-Lindu Nationalparks unterscheidet sich zwischen umliegenden Dörfern stärker, als dies durch quantitative Haushaltsdaten zu erkl

  19. General Relativity

    CERN Document Server

    Straumann, Norbert

    2013-01-01

    This book provides a completely revised and expanded version of the previous classic edition ‘General Relativity and Relativistic Astrophysics’. In Part I the foundations of general relativity are thoroughly developed, while Part II is devoted to tests of general relativity and many of its applications. Binary pulsars – our best laboratories for general relativity – are studied in considerable detail. An introduction to gravitational lensing theory is included as well, so as to make the current literature on the subject accessible to readers. Considerable attention is devoted to the study of compact objects, especially to black holes. This includes a detailed derivation of the Kerr solution, Israel’s proof of his uniqueness theorem, and a derivation of the basic laws of black hole physics. Part II ends with Witten’s proof of the positive energy theorem, which is presented in detail, together with the required tools on spin structures and spinor analysis. In Part III, all of the differential geomet...

  20. Measuring and Examining General Self-Efficacy among Community College Students: A Structural Equation Modeling Approach

    Science.gov (United States)

    Chen, Yu; Starobin, Soko S.

    2018-01-01

    This study examined a psychosocial mechanism of how general self-efficacy interacts with other key factors and influences degree aspiration for students enrolled in an urban diverse community college. Using general self-efficacy scales, the authors hypothesized the General Self-efficacy model for Community College students (the GSE-CC model). A…

  1. Structure of the US gas market, regulation and pricing of the third party access to the network

    International Nuclear Information System (INIS)

    David, L.; Mirabel, F.

    2000-06-01

    The opening of the US natural gas market to competition is followed by deep changes in the implemented regulations for an efficient organization and operation of the gas industry. The transformations of the industrial structures and the strategic behavior of the actors characterize the mutations of the gas markets in the USA. The aim of this paper is to transcribe in a synthetic form the characteristics of the gas market in North America and to model the structure of the industry in this sector opened to competition in its back-end. Two main questions are analyzed: the role and position of the former monopoly (utility) in this back-end market (should the local distribution companies continue to sell gas to end users?), and what kind of regulation should be implemented by the authorities in order to avoid the former monopoly to use its market power and make excessive profits. The analysis is made in two steps: the first part explains the hypotheses of the analysis using the characteristics of the North American market. It presents the general framework of the model and explains the two 'regulatory scenarios' retained in the study. The main steps of the resolution of the model are detailed in the second part. (J.S.)

  2. The structure of psychological life satisfaction: insights from farmers and a general community sample in Australia

    Science.gov (United States)

    2012-01-01

    Background Psychological life satisfaction is a robust predictor of wellbeing. Public health measures to improve wellbeing would benefit from an understanding of how overall life satisfaction varies as a function of satisfaction with multiple life domains, an area that has been little explored. We examine a sample of drought-affected Australian farmers and a general community sample of Australians to investigate how domain satisfaction combines to form psychological satisfaction. In particular, we introduce a way of statistically testing for the presence of “supra-domains” of satisfaction to propose a novel way of examining the composition of psychological life satisfaction to gain insights for health promotion and policy. Methods Covariance between different perceptions of life domain satisfaction was identified by conducting correlation, regression, and exploratory factor analyses on responses to the Personal Wellbeing Index. Structural equations modelling was then used to (a) validate satisfaction supra-domain constructs emerging from different perceptions of life domain satisfaction, and (b) model relationships between supra-domains and an explicit measure of psychological life satisfaction. Results Perceived satisfaction with eight different life domains loaded onto a single unitary satisfaction construct adequately in each sample. However, in both samples, different domains better loaded onto two separate but correlated constructs (‘supra-domains’): “satisfaction with connectedness” and “satisfaction with efficacy”. Modelling reciprocal pathways between these supra-domains and an explicit measure of psychological life satisfaction revealed that efficacy mediated the link between connectedness and psychological satisfaction. Conclusions If satisfaction with connectedness underlies satisfaction with efficacy (and thus psychological satisfaction), a novel insight for health policy emerges: psychological life satisfaction, a vital part of

  3. Jupiter Thermospheric General Circulation Model (JTGCM): Global Structure and Dynamics Driven by Auroral and Joule Heating

    Science.gov (United States)

    Bougher, S. W.; J. Il. Waite, Jr.; Majeed, T.

    2005-01-01

    A growing multispectral database plus recent Galileo descent measurements are being used to construct a self-consistent picture of the Jupiter thermosphere/ionosphere system. The proper characterization of Jupiter s upper atmosphere, embedded ionosphere, and auroral features requires the examination of underlying processes, including the feedbacks of energetics, neutral-ion dynamics, composition, and magnetospheric coupling. A fully 3-D Jupiter Thermospheric General Circulation Model (JTGCM) has been developed and exercised to address global temperatures, three-component neutral winds, and neutral-ion species distributions. The domain of this JTGCM extends from 20-microbar (capturing hydrocarbon cooling) to 1.0 x 10(exp -4) nbar (including aurora/Joule heating processes). The resulting JTGCM has been fully spun-up and integrated for greater than or equal to40 Jupiter rotations. Results from three JTGCM cases incorporating moderate auroral heating, ion drag, and moderate to strong Joule heating processes are presented. The neutral horizontal winds at ionospheric heights vary from 0.5 km/s to 1.2 km/s, atomic hydrogen is transported equatorward, and auroral exospheric temperatures range from approx.1200-1300 K to above 3000 K, depending on the magnitude of Joule heating. The equatorial temperature profiles from the JTGCM are compared with the measured temperature structure from the Galileo AS1 data set. The best fit to the Galileo data implies that the major energy source for maintaining the equatorial temperatures is due to dynamical heating induced by the low-latitude convergence of the high-latitude-driven thermospheric circulation. Overall, the Jupiter thermosphere/ionosphere system is highly variable and is shown to be strongly dependent on magnetospheric coupling which regulates Joule heating.

  4. The structure of psychological life satisfaction: insights from farmers and a general community sample in Australia

    Directory of Open Access Journals (Sweden)

    OBrien Léan V

    2012-11-01

    Full Text Available Abstract Background Psychological life satisfaction is a robust predictor of wellbeing. Public health measures to improve wellbeing would benefit from an understanding of how overall life satisfaction varies as a function of satisfaction with multiple life domains, an area that has been little explored. We examine a sample of drought-affected Australian farmers and a general community sample of Australians to investigate how domain satisfaction combines to form psychological satisfaction. In particular, we introduce a way of statistically testing for the presence of “supra-domains” of satisfaction to propose a novel way of examining the composition of psychological life satisfaction to gain insights for health promotion and policy. Methods Covariance between different perceptions of life domain satisfaction was identified by conducting correlation, regression, and exploratory factor analyses on responses to the Personal Wellbeing Index. Structural equations modelling was then used to (a validate satisfaction supra-domain constructs emerging from different perceptions of life domain satisfaction, and (b model relationships between supra-domains and an explicit measure of psychological life satisfaction. Results Perceived satisfaction with eight different life domains loaded onto a single unitary satisfaction construct adequately in each sample. However, in both samples, different domains better loaded onto two separate but correlated constructs (‘supra-domains’: “satisfaction with connectedness” and “satisfaction with efficacy”. Modelling reciprocal pathways between these supra-domains and an explicit measure of psychological life satisfaction revealed that efficacy mediated the link between connectedness and psychological satisfaction. Conclusions If satisfaction with connectedness underlies satisfaction with efficacy (and thus psychological satisfaction, a novel insight for health policy emerges: psychological life satisfaction

  5. Fission, fusion and annihilation in the interaction of localized structures for the (2 + 1)-dimensional generalized Broer-Kaup system

    International Nuclear Information System (INIS)

    Yomba, Emmanuel; Peng, Yan-ze

    2006-01-01

    Based on the WTC truncation method and the general variable separation approach (GVSA), we have first found a general solution including three arbitrary functions for the (2 + 1)-dimensional simplified generalized Broer-Kaup (GBK) system (B = 0). A class of double periodic wave solutions is obtained by selecting these arbitrary functions appropriately. The interaction properties of the periodic waves are numerically studied and found to be non-elastic. Limit cases are considered and some new localized coherent structures are obtained, the interaction properties of these solutions reveal that some of them are completely elastic and some are non-completely elastic. After that, starting from the (2 + 1)-dimensional GBK system (B ≠ 0) and using the variable separation approach (VSA) including two arbitrary functions in the general solution, we have constructed by selecting the two arbitrary functions appropriately a rich variety of new coherent structures. The interaction properties of these structures reveal new physical properties like fusion, fission, or both and present mutual annihilation of these solutions as time increasing. The annihilation in this model has found to be rule by the parameter K 1 , when this parameter is taken to be zero, the annihilation disappears in this model and the above mentioned structures recover the solitonic structure properties

  6. Structural violence and simplified paternalistic ideas of patient empowerment decreases health care access, quality & outcome for ethnic minority patients

    DEFF Research Database (Denmark)

    Sodemann, Morten

    Increasing complexity of health care organization, rapid hyperspecialization of medical care, lack of ’patient literacy’ and pressure on patients to take over responsibility, challenges political dreams of equal access to patient centered high quality secure care....

  7. The Factor Structure of ADHD in a General Population of Primary School Children

    Science.gov (United States)

    Ullebo, Anne Karin; Breivik, Kyrre; Gillberg, Christopher; Lundervold, Astri J.; Posserud, Maj-Britt

    2012-01-01

    Objective: To examine whether a bifactor model with a general ADHD factor and domain specific factors of inattention, hyperactivity and impulsivity was supported in a large general population sample of children. We also explored the utility of forming subscales based on the domain-specific factors. Methods: Child mental health questionnaires were…

  8. Spatio-temporal map generalizations with the hierarchical Voronoi data structure

    DEFF Research Database (Denmark)

    Mioc, Darka; Anton, François; Gold, Christopher M.

    implemented in commercial GIS systems. In this research, we used the Voronoi spatial data model for map generalizations. We were able to demonstrate that the map generalization does not affect only spatial objects (points, lines or polygons), but also the events corresponding to the creation and modification...... their spatio-temporal characteristics and their dynamic behaviour....

  9. Constraints on the structure of naked singularities in classical general relativity

    International Nuclear Information System (INIS)

    Newman, R.P.A.; Joshi, P.S.

    1988-01-01

    The known examples of naked singularities in general relativity are, in a certain sense, either gravitationally or causally innocuous. A cosmic censorship theorem is formulated and proved to the effect that this behaviour is characteristic of naked singularities in general spacetimes which do not deviate too far from spherical symmetry. copyright 1988 Academic Press, Inc

  10. Amphibian and reptile road-kills on tertiary roads in relation to landscape structure: using a citizen science approach with open-access land cover data.

    Science.gov (United States)

    Heigl, Florian; Horvath, Kathrin; Laaha, Gregor; Zaller, Johann G

    2017-06-26

    Amphibians and reptiles are among the most endangered vertebrate species worldwide. However, little is known how they are affected by road-kills on tertiary roads and whether the surrounding landscape structure can explain road-kill patterns. The aim of our study was to examine the applicability of open-access remote sensing data for a large-scale citizen science approach to describe spatial patterns of road-killed amphibians and reptiles on tertiary roads. Using a citizen science app we monitored road-kills of amphibians and reptiles along 97.5 km of tertiary roads covering agricultural, municipal and interurban roads as well as cycling paths in eastern Austria over two seasons. Surrounding landscape was assessed using open access land cover classes for the region (Coordination of Information on the Environment, CORINE). Hotspot analysis was performed using kernel density estimation (KDE+). Relations between land cover classes and amphibian and reptile road-kills were analysed with conditional probabilities and general linear models (GLM). We also estimated the potential cost-efficiency of a large scale citizen science monitoring project. We recorded 180 amphibian and 72 reptile road-kills comprising eight species mainly occurring on agricultural roads. KDE+ analyses revealed a significant clustering of road-killed amphibians and reptiles, which is an important information for authorities aiming to mitigate road-kills. Overall, hotspots of amphibian and reptile road-kills were next to the land cover classes arable land, suburban areas and vineyards. Conditional probabilities and GLMs identified road-kills especially next to preferred habitats of green toad, common toad and grass snake, the most often found road-killed species. A citizen science approach appeared to be more cost-efficient than monitoring by professional researchers only when more than 400 km of road are monitored. Our findings showed that freely available remote sensing data in combination with a

  11. General access to metal oxide (Metal = Mn, Co, Ni) double-layer nanospheres for application in lithium ion batteries and supercapacitors

    International Nuclear Information System (INIS)

    Xia, Yuan; Wang, Gang; Zhang, Xing; Wang, Beibei; Wang, Hui

    2016-01-01

    Highlights: • A series of metal oxide double layer nanospheres were prepared. • The obtained materials show excellent performances in lithium ion batteries and supercapacitors. • The unique structure of double layers is beneficial for superior electrochemical performances. - Abstract: In this work, a series of metal oxide double-layer nanospheres (DLNs), such as Mn 2 O 3 , Co 3 O 4 , NiO, NiCo 2 O 4 , and MnCo 2 O 4 have been successfully synthesized through a general template method. The layers of nanospheres were assembled by different nanostructure units and the removing of the SiO 2 template formed a void of several ten nanometers between the double layers, resulting large specific surface areas for them. The energy storage performances of the as-prepared double-layer nanospheres were further investigated in lithium ion battery and supercapacitor systems. Based on their unique nanostructures, the double-layer nanospheres exhibit excellent electrochemical performance with long cycle stability and high specific capacities or capacitances. The best of these, DLNs-NiCo 2 O 4 can deliver a reversible capacity of 1107 mAh g −1 at 0.25C after 200 cycles in lithium ion battery system, and shows a capacitance of 1088 F g −1 with capacitance loss of less than 3% at 5 A g −1 after 5000 cycles in supercapacitors.

  12. Direct Linear System Identification Method for Multistory Three-dimensional Building Structure with General Eccentricity

    OpenAIRE

    Shintani, Kenichirou; Yoshitomi, Shinta; Takewaki, Izuru

    2017-01-01

    A method of physical parameter system identification (SI) is proposed here for three-dimensional (3D) building structures with in-plane rigid floors in which the stiffness and damping coefficients of each structural frame in the 3D building structure are identified from the measured floor horizontal accelerations. A batch processing least-squares estimation method for many discrete time domain measured data is proposed for the direct identification of the stiffness and damping coefficients of...

  13. Validity Generalization of the WISC-R Factor Structure with 10 1/2-Year-Old Children.

    Science.gov (United States)

    Shiek, David A.; Miller, John E.

    1978-01-01

    Investigated robustness of the Wechsler Intelligence Scale for Children-Revised (WISC-R) factor structure. Comparisons of the loadings obtained with generalization sample and 10 1/2-year-old national standardization sample suggest high degree of similarity in composition, magnitude, and pattern. Findings highly support robustness of WISC-R's…

  14. Different perceptions of stress, coping styles, and general well-being among pregnant Chinese women: a structural equation modeling approach.

    Science.gov (United States)

    Lau, Ying; Tha, Pyai Htun; Wong, Daniel Fu Keung; Wang, Yuqiong; Wang, Ying; Yobas, Piyanee Klainin

    2016-02-01

    Few studies have examined different perceptions of stress or explored the positive aspects of well-being among pregnant Chinese women, so there is a need to explore these phenomena in order to fill the research gap. The aim of this study was to examine the relationships among the different perceptions of stress, coping styles, and general well-being using a structural equation modeling approach. We examined a hypothetical model among 755 pregnant Chinese women based on the integration of theoretical models. The Perceived Stress Scale (PSS), the Trait Coping Styles Questionnaire (TCSQ), and the General Well-Being Schedule (GWB) were used to measure perceived stress, coping styles, and general well-being, respectively. A structural equation model showed that positive and negative perceptions of stress significantly influenced positive and negative coping styles, respectively. Different perceptions of stress were significantly associated with general well-being, but different coping styles had no significant effects on general well-being. The model had a good fit to the data (IFI = 0.910, TLI = 0.904, CFI = 0.910, and RMSEA = 0.038). Different perception of stress was able to predict significant differences in coping styles and general well-being.

  15. Genetic structure and admixture between Bayash Roma from northwestern Croatia and general Croatian population: evidence from Bayesian clustering analysis.

    Science.gov (United States)

    Novokmet, Natalija; Galov, Ana; Marjanović, Damir; Škaro, Vedrana; Projić, Petar; Lauc, Gordan; Primorac, Dragan; Rudan, Pavao

    2015-01-01

    The European Roma represent a transnational mosaic of minority population groups with different migration histories and contrasting experiences in their interactions with majority populations across the European continent. Although historical genetic contributions of European lineages to the Roma pool were investigated before, the extent of contemporary genetic admixture between Bayash Roma and non-Romani majority population remains elusive. The aim of this study was to assess the genetic structure of the Bayash Roma population from northwestern Croatia and the general Croatian population and to investigate the extent of admixture between them. A set of genetic data from two original studies (100 Bayash Roma from northwestern Croatia and 195 individuals from the general Croatian population) was analyzed by Bayesian clustering implemented in STRUCTURE software. By re-analyzing published data we intended to focus for the first time on genetic differentiation and structure and in doing so we clearly pointed to the importance of considering social phenomena in understanding genetic structuring. Our results demonstrated that two population clusters best explain the genetic structure, which is consistent with social exclusion of Roma and the demographic history of Bayash Roma who have settled in NW Croatia only about 150 years ago and mostly applied rules of endogamy. The presence of admixture was revealed, while the percentage of non-Croatian individuals in general Croatian population was approximately twofold higher than the percentage of non-Romani individuals in Roma population corroborating the presence of ethnomimicry in Roma.

  16. Seeking Structural Specificity: Direct Modulation of Pentameric Ligand-Gated Ion Channels by Alcohols and General Anesthetics

    Science.gov (United States)

    Trudell, James R.; Harris, R. Adron

    2014-01-01

    Alcohols and other anesthetic agents dramatically alter neurologic function in a wide range of organisms, yet their molecular sites of action remain poorly characterized. Pentameric ligand-gated ion channels, long implicated in important direct effects of alcohol and anesthetic binding, have recently been illuminated in renewed detail thanks to the determination of atomic-resolution structures of several family members from lower organisms. These structures provide valuable models for understanding and developing anesthetic agents and for allosteric modulation in general. This review surveys progress in this field from function to structure and back again, outlining early evidence for relevant modulation of pentameric ligand-gated ion channels and the development of early structural models for ion channel function and modulation. We highlight insights and challenges provided by recent crystal structures and resulting simulations, as well as opportunities for translation of these newly detailed models back to behavior and therapy. PMID:24515646

  17. Circular Discernment in Completely Extensive Structures and How to Avoid such Circles Generally

    NARCIS (Netherlands)

    Muller, F.A.

    2012-01-01

    In this journal, D. Rizza [11] (p. 176) expounded a solution of what he called “the indiscernibility problem for ante rem structuralism”, which is the problem to make sense of the presence, in structures, of objects that are indiscernible yet distinct, by only appealing to what that structure

  18. A generalized one-factor term structure model and pricing of interest rate derivative securities

    NARCIS (Netherlands)

    Jiang, George J.

    1997-01-01

    The purpose of this paper is to propose a nonparametric interest rate term structure model and investigate its implications on term structure dynamics and prices of interest rate derivative securities. The nonparametric spot interest rate process is estimated from the observed short-term interest

  19. Broadband Access

    Indian Academy of Sciences (India)

    First page Back Continue Last page Overview Graphics. Broadband Access. Worldwide market for broadband access $30 Billion! Over 200 million broadband subscribers worldwide! Various Competing Broadband access. Digital Subscriber line; Wireless; Optical Fiber.

  20. Apollo: giving application developers a single point of access to public health models using structured vocabularies and Web services.

    Science.gov (United States)

    Wagner, Michael M; Levander, John D; Brown, Shawn; Hogan, William R; Millett, Nicholas; Hanna, Josh

    2013-01-01

    This paper describes the Apollo Web Services and Apollo-SV, its related ontology. The Apollo Web Services give an end-user application a single point of access to multiple epidemic simulators. An end user can specify an analytic problem-which we define as a configuration and a query of results-exactly once and submit it to multiple epidemic simulators. The end user represents the analytic problem using a standard syntax and vocabulary, not the native languages of the simulators. We have demonstrated the feasibility of this design by implementing a set of Apollo services that provide access to two epidemic simulators and two visualizer services.

  1. Symmetries and Curvature Structure in General Relativity (World Scientific Lecture Notes in Physics Vol 47)

    International Nuclear Information System (INIS)

    Cornish, F H J

    2004-01-01

    This new edition of Hans Stephani's book is a welcome addition to the many texts now available to the student wishing to study relativity. A new feature, as compared with earlier editions, is a substantial introductory section on special relativity amounting to almost a quarter of the total length of the book. This forms part I and covers all the usual topics one might expect, including particle mechanics, the formulae for aberration and the Doppler effect, tensors in Minkowski spacetime, Maxwell's equations and the energy-momentum tensor for the electromagnetic field, the equations of motion for charged point particles and their fields (with a brief discussion of radiation reaction and runaway solutions) and the energy-momentum tensor for a perfect fluid. But there is also a useful section on the algebraic classification of the electromagnetic field using the apparatus of null tetrads and self-dual bivectors. An unusual feature is a section on pole-dipole charged particles. General relativity is introduced and developed in parts II to VII of the book, which follow closely the text of the 1982 English edition. In part II, the reasons for regarding spacetime as a four-dimensional Riemannian manifold with a metric of Lorentz signature are clearly explained. There follows a concise treatment of the tensor calculus including the covariant derivative, parallel and Fermi-Walker transport, the Lie derivative and the properties of the Riemann tensor. Invariant forms for line, surface and volume integrals are discussed and Stokes' theorem is stated without proof. There is a final section on how physical laws within special relativity may be generalized to curved spacetime. Part III introduces the reader to the Einstein field equations. Schwarzschild's exterior solution and Birkoff's theorem are derived, as are the usual formulae for the perihelion advance for planetary orbits, the deflection of light rays, the gravitational red shift and the geodesic precession of a top

  2. General asymmetric neutral networks and structure design by genetic algorithms: A learning rule for temporal patterns

    Energy Technology Data Exchange (ETDEWEB)

    Bornholdt, S. [Heidelberg Univ., (Germany). Inst., fuer Theoretische Physik; Graudenz, D. [Lawrence Berkeley Lab., CA (United States)

    1993-07-01

    A learning algorithm based on genetic algorithms for asymmetric neural networks with an arbitrary structure is presented. It is suited for the learning of temporal patterns and leads to stable neural networks with feedback.

  3. General asymmetric neutral networks and structure design by genetic algorithms: A learning rule for temporal patterns

    International Nuclear Information System (INIS)

    Bornholdt, S.

    1993-07-01

    A learning algorithm based on genetic algorithms for asymmetric neural networks with an arbitrary structure is presented. It is suited for the learning of temporal patterns and leads to stable neural networks with feedback

  4. General structure of quantum mechanics. The objections raised by Einstein, Podolsky and Rosen

    International Nuclear Information System (INIS)

    Laloe, F.

    1981-01-01

    First, the general formulation of quantum mechanics is briefly presented, with the so called 'Copenhagen interpretation', and a few very simple examples are given. Then, the general experimental scheme imagined by Einstein, Podolsky and Rosen is discussed in detail, for two correlated spin 1/2 particules, in terms of the elements of physical reality which can be attached to the system. A macroscopic analogue is given, in order to emphasize how strange the language of quantum mechanics may become when applied to every day life phenomena, where all correlation phenomena are explained in terms of a common cause in the past. Finally, the notions of separability, locality and determinism are introduced [fr

  5. General scheme for elucidating the structure of organic compounds using spectroscopic and spectrometric methods

    International Nuclear Information System (INIS)

    Ribeiro, Carlos Magno R.; Souza, Nelson Angelo de

    2007-01-01

    This work describes a systematic method to be applied in undergraduate courses of organic chemistry, correlating infrared spectra, hydrogen and carbon-13 nuclear magnetic resonance, and mass spectra. To this end, a scheme and a table were developed to conduct the elucidation of the structure of organic compounds initially using infrared spectra. Interpretation of hydrogen and carbon-13 nuclear magnetic resonance spectra and of mass spectra is used to confirm the proposed structure. (author)

  6. A Concept for the Use and Integration of Super-Conducting Magnets in Structural Systems in General and Maglev Guideway Mega-Structures in Particular

    Science.gov (United States)

    Ussery, Wilfred T.; MacCalla, Eric; MacCalla, Johnetta; Elnimeiri, Mahjoub; Goldsmith, Myron; Polk, Sharon Madison; Jenkins, Mozella; Bragg, Robert H.

    1996-01-01

    Recent breakthroughs in several different fields now make it possible to incorporate the use of superconducting magnets in structures in ways which enhance the performance of structural members or components of structural systems in general and Maglev guideway mega-structures in particular. The building of structural systems which connect appropriately scaled superconducting magnets with the post-tensioned tensile components of beams, girders, or columns would, if coupled with 'state of the art' structure monitoring, feedback and control systems, and advanced computer software, constitute a distinct new generation of structures that would possess the unique characteristic of being heuristic and demand or live-load responsive. The holistic integration of powerful superconducting magnets in structures so that they do actual structural work, creates a class of 'technologically endowed' structures that, in part - literally substitute superconductive electric power and magnetism for concrete and steel. The research and development engineering, and architectural design issues associated with such 'technologically endowed' structural system can now be conceptualized, designed, computer simulates built and tested. The Maglev guideway mega-structure delineated herein incorporates these concepts, and is designed for operation in the median strip of U.S. Interstate Highway 5 from San Diego to Seattle an Vancouver, and possibly on to Fairbanks, Alaska. This system also fits in the median strip of U.S. Interstate Highway 55 and 95 North-South, and 80 and 10, East-West. As a Western Region 'Peace Dividend' project, it could become a National or Bi-National research, design and build, super turnkey project that would create thousands of jobs by applying superconducting, material science, electronic aerospace and other defense industry technologies to a multi-vehicle, multi-use Maglev guideway megastructure that integrates urban mass transit Lower Speed (0-100 mph), High Speed

  7. Personality Traits and General Intelligence as Predictors of Academic Performance: A Structural Equation Modelling Approach

    Science.gov (United States)

    Rosander, Pia; Backstrom, Martin; Stenberg, Georg

    2011-01-01

    The aim of the present study was to investigate the extent to which personality traits, after controlling for general intelligence, predict academic performance in different school subjects. Upper secondary school students in Sweden (N=315) completed the Wonderlic IQ test (Wonderlic, 1992) and the IPIP-NEO-PI test (Goldberg, 1999). A series of…

  8. Combining a popularity-productivity stochastic block model with a discriminative-content model for general structure detection.

    Science.gov (United States)

    Chai, Bian-fang; Yu, Jian; Jia, Cai-Yan; Yang, Tian-bao; Jiang, Ya-wen

    2013-07-01

    Latent community discovery that combines links and contents of a text-associated network has drawn more attention with the advance of social media. Most of the previous studies aim at detecting densely connected communities and are not able to identify general structures, e.g., bipartite structure. Several variants based on the stochastic block model are more flexible for exploring general structures by introducing link probabilities between communities. However, these variants cannot identify the degree distributions of real networks due to a lack of modeling of the differences among nodes, and they are not suitable for discovering communities in text-associated networks because they ignore the contents of nodes. In this paper, we propose a popularity-productivity stochastic block (PPSB) model by introducing two random variables, popularity and productivity, to model the differences among nodes in receiving links and producing links, respectively. This model has the flexibility of existing stochastic block models in discovering general community structures and inherits the richness of previous models that also exploit popularity and productivity in modeling the real scale-free networks with power law degree distributions. To incorporate the contents in text-associated networks, we propose a combined model which combines the PPSB model with a discriminative model that models the community memberships of nodes by their contents. We then develop expectation-maximization (EM) algorithms to infer the parameters in the two models. Experiments on synthetic and real networks have demonstrated that the proposed models can yield better performances than previous models, especially on networks with general structures.

  9. A new hierarchy of generalized derivative nonlinear Schroedinger equations, its bi-Hamiltonian structure and finite-dimensional involutive system

    International Nuclear Information System (INIS)

    Yan, Z.; Zhang, H.

    2001-01-01

    In this paper, an isospectral problem and one associated with a new hierarchy of nonlinear evolution equations are presented. As a reduction, a representative system of new generalized derivative nonlinear Schroedinger equations in the hierarchy is given. It is shown that the hierarchy possesses bi-Hamiltonian structures by using the trace identity method and is Liouville integrable. The spectral problem is non linearized as a finite-dimensional completely integrable Hamiltonian system under a constraint between the potentials and spectral functions. Finally, the involutive solutions of the hierarchy of equations are obtained. In particular, the involutive solutions of the system of new generalized derivative nonlinear Schroedinger equations are developed

  10. Information-preserving structures: A general framework for quantum zero-error information

    International Nuclear Information System (INIS)

    Blume-Kohout, Robin; Ng, Hui Khoon; Poulin, David; Viola, Lorenza

    2010-01-01

    Quantum systems carry information. Quantum theory supports at least two distinct kinds of information (classical and quantum), and a variety of different ways to encode and preserve information in physical systems. A system's ability to carry information is constrained and defined by the noise in its dynamics. This paper introduces an operational framework, using information-preserving structures, to classify all the kinds of information that can be perfectly (i.e., with zero error) preserved by quantum dynamics. We prove that every perfectly preserved code has the same structure as a matrix algebra, and that preserved information can always be corrected. We also classify distinct operational criteria for preservation (e.g., 'noiseless','unitarily correctible', etc.) and introduce two natural criteria for measurement-stabilized and unconditionally preserved codes. Finally, for several of these operational criteria, we present efficient (polynomial in the state-space dimension) algorithms to find all of a channel's information-preserving structures.

  11. Halley comet position in structure of the comet origin general scheme

    International Nuclear Information System (INIS)

    Davydov, V.D.

    1988-01-01

    Attempt to explain data on the Halley comet nucleus figure by photographes received from space probes in 1986 was undertaken. Peanut-like nucleus might be formed from two bodies former system under specific conditions. This hypothesis preliminary development is made; solution way for the problem about quantitative characteristics of collision and destruction is found. Quantitative assessments confirm retention possibility of two space icebergs original form after their ''docking'' within relative velocity range up to a few meters per second. Then complex with visible saddle point between two jointed fragments is formed. The hypothesis suggested is well inscribed in the origin general scheme of comets with nucleus different types, and from general scheme one may draw up the most important details to this hypothesis (for example, power mechanism of binary system formation and reasons of its destabilization)

  12. Application of Structural Equations Modeling to assess relationship among Emotional Intelligence, General Health and Occupational Accidents

    OpenAIRE

    MOAMMAD KHANDAN; AMIR KAVOUSI; ALIREZA KOOHPAEI

    2015-01-01

    ORIGINAL ARTICLEEmotional intelligence (EI) has been subject of significant amounts of literature over the past two decades. However, little has been contributed to how emotional intelligence may be practically applied to enhance both accident prevention program and general health in workplaces. Purpose of this paper is to survey relationship among these variables in working society of Iran in 2014. As well as identify practical approaches to application of emotional intelligence skills to ma...

  13. INTERACTIONAL-GNOSTIC COMPONENT IN THE STRUCTURE OF GENERAL HUMANITARIAN BASIS OF EDUCATION

    OpenAIRE

    Tamara M. ELKANOVA

    2015-01-01

    The interactional-gnostic component of author's conceptual and theoretical model of general humanitarian basis of education provides integration at the level of development of different in the ontologic ways of knowledge of the world, training in associative and figurative thinking, translation from objective external language into internal language of figurative and conceptual models of reality, strengthening of attention to axiological notional content of the received knowledge, formation o...

  14. Real Hypersurfaces of Nonflat Complex Projective Planes Whose Jacobi Structure Operator Satisfies a Generalized Commutative Condition

    Directory of Open Access Journals (Sweden)

    Theocharis Theofanidis

    2016-01-01

    Full Text Available Real hypersurfaces satisfying the condition ϕl=lϕ(l=R(·,ξξ have been studied by many authors under at least one more condition, since the class of these hypersurfaces is quite tough to be classified. The aim of the present paper is the classification of real hypersurfaces in complex projective plane CP2 satisfying a generalization of ϕl=lϕ under an additional restriction on a specific function.

  15. Possible Simple Structures of the Universe to Include General Relativity Effects

    Directory of Open Access Journals (Sweden)

    Corneliu BERBENTE

    2017-12-01

    Full Text Available The general relativity describes the universe properties, the gravity playing a fundamental role. One uses a metric tensor in a Riemann space, g  , which should be in agreement with a mass (or energy tensor in order to satisfy the Einstein equation of the general relativity [1]. This equation contains the Ricci curvature as well. In general, applications are done considering that a chosen metric is valid without region limits. In fact, the density of the energy whose distribution is however unknown is variable in universe; therefore, the metrics need to be adapted to different regions. For this reason one suggests to start with a simple, average mass-energy distribution that could represent in a first step the actual universe. This suggestion is in agreement with the symmetrical distribution of equal spheres existing in a model of the early universe given by one of the authors. Two kinds of distribution are given. The possibility of black holes formation is studied and a criterion is given.

  16. The objective structured clinical examination revisited for postgraduate trainees in general practice.

    Science.gov (United States)

    Schoenmakers, Birgitte; Wens, Johan

    2014-03-04

    To investigate if the psychometric qualities of an OSCE consisting of more complex simulated patient encounters remain valid and reliable in the assessment of postgraduate trainees in general practice. In this intervention study without control group, the traditional OSCE was formally replaced by the new, complex version. The study population was composed by all postgraduate trainees (second and third phase) in general practice during the ongoing academic year. Data were handled and collected as part of the formal assessment program. Univariate analyses, the variance of scores and multivariate analyses were performed to assess the test qualities. A total of 340 students participated. Average final scores were slightly higher for third-phase students (t-test, p =0.05). Overall test scores were equally distributed on station level, circuit level and phase level. A multiple regression analysis revealed that test scores were dependent on the stations and circuits, but not on the master phase. In a changing learning environment, assessment and evaluation strategies require reorientation. The reliability and validity of the OSCE remain subject to discussion. In particular, when it comes to content and design, the traditional OSCE might underestimate the performance level of postgraduate trainees in general practice. A reshaping of this OSCE to a more sophisticated design with more complex patient encounters appears to restore the validity of the test results.

  17. A general method for computing the total solar radiation force on complex spacecraft structures

    Science.gov (United States)

    Chan, F. K.

    1981-01-01

    The method circumvents many of the existing difficulties in computational logic presently encountered in the direct analytical or numerical evaluation of the appropriate surface integral. It may be applied to complex spacecraft structures for computing the total force arising from either specular or diffuse reflection or even from non-Lambertian reflection and re-radiation.

  18. No evidence for general condition-dependence of structural plumage colour in blue tits: an experiment

    NARCIS (Netherlands)

    Peters, A.; Kurvers, R.H.J.M.; Roberts, M.L.; Delhey, K.

    2011-01-01

    Condition-dependence is a central but contentious tenet of evolutionary theories on the maintenance of ornamental traits, and this is particularly true for structural plumage colour. By providing diets of different nutritional quality to moulting male and female blue tits, we experimentally

  19. Structural Model for Antisocial Behavior: Generalization to Single-Mother Families.

    Science.gov (United States)

    Baldwin, David V.; Skinner, Martie L.

    1989-01-01

    The purpose of this study was to replicate the "basic training" structural model in Patterson's (1982) coercion theory, extending its scope to single-mother families with younger (six- to eight-year-old) boys. Significance of the successful replication was seen to lie in implications for the generalizability of the model across family…

  20. The Structure of Autism Spectrum Disorder Symptoms in the General Population at 18 Months

    Science.gov (United States)

    Beuker, Karin T.; Schjolberg, Synnve; Lie, Kari Kveim; Donders, Rogier; Lappenschaar, Martijn; Swinkels, Sophie H. N.; Buitelaar, Jan K.

    2013-01-01

    It is unclear whether symptoms of autism spectrum disorder (ASD) in young children in the population fit the three-factor structure of ASD as described in the DSM-IV, and cluster together in individual subjects. This study analysed questionnaire data on ASD symptoms filled in by mothers of 11,332 18-month-old children that was collected in the…

  1. Generalized switching regression analysis of private and public sector wage structures in Germany

    NARCIS (Netherlands)

    Dustmann, C.; van Soest, A.H.O.

    1995-01-01

    This paper analyzes wage structures in the public and the private sector for Germany. The data contains a rich set of variables on parents' characteristics that we use as instruments. We extend the empirical literature in this field by endogenizing education level and hours worked, and by using life

  2. General point dipole theory for periodic metasurfaces: magnetoelectric scattering lattices coupled to planar photonic structures.

    Science.gov (United States)

    Chen, Yuntian; Zhang, Yan; Femius Koenderink, A

    2017-09-04

    We study semi-analytically the light emission and absorption properties of arbitrary stratified photonic structures with embedded two-dimensional magnetoelectric point scattering lattices, as used in recent plasmon-enhanced LEDs and solar cells. By employing dyadic Green's function for the layered structure in combination with the Ewald lattice summation to deal with the particle lattice, we develop an efficient method to study the coupling between planar 2D scattering lattices of plasmonic, or metamaterial point particles, coupled to layered structures. Using the 'array scanning method' we deal with localized sources. Firstly, we apply our method to light emission enhancement of dipole emitters in slab waveguides, mediated by plasmonic lattices. We benchmark the array scanning method against a reciprocity-based approach to find that the calculated radiative rate enhancement in k-space below the light cone shows excellent agreement. Secondly, we apply our method to study absorption-enhancement in thin-film solar cells mediated by periodic Ag nanoparticle arrays. Lastly, we study the emission distribution in k-space of a coupled waveguide-lattice system. In particular, we explore the dark mode excitation on the plasmonic lattice using the so-called array scanning method. Our method could be useful for simulating a broad range of complex nanophotonic structures, i.e., metasurfaces, plasmon-enhanced light emitting systems and photovoltaics.

  3. Traffic Load on Interconnection Lines of Generalized Double Ring Network Structures

    DEFF Research Database (Denmark)

    Pedersen, Jens Myrup; Riaz, Muhammad Tahir; Madsen, Ole Brun

    2005-01-01

    consists of two planar rings, which are easily embedded by fiber or other wired solutions. It is shown that for large N2R structures, the interconnection lines carry notably lower loads than the other lines if shortest-path routing is used, and the effects of two other routing schemes are explored, leading...

  4. Global gridded physical profile data from the U.S. Navy's Generalized Digital Environmental Model (GDEM) product database (NODC Accession 9600094)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Generalized Digital Environmental Model (GDEM) is a four-dimensional (4-D) steady-state digital model of ocean temperature and salinity. The model consists of...

  5. General Concerns Life-Cycle Design of Economical Ice-Resistant Structures in the Bohai Sea

    Directory of Open Access Journals (Sweden)

    Zhang Da-yong

    2017-08-01

    Full Text Available In China, the oil and natural gas resources of Bohai Bay are mainly marginal oil fields. It is necessary to build both iceresistant and economical offshore platforms. However, there are many risks during the life cycle of offshore platforms due to the imperfect preliminary design for the Bohai Sea economical ice-resistant structures. As a result, the whole life-cycle design should be considered, including plan, design, construction, management and maintenance design. Based on the demand of existing codes and research of the basic design, structural ice-resistant performance and the reasonable management and maintenance, the life-cycle design theory is discussed. It was concluded that the life-cycle cost-effective optimum design proposed will lead to a minimum risk.

  6. A generalization of the quantum Rabi model: exact solution and spectral structure

    International Nuclear Information System (INIS)

    Eckle, Hans-Peter; Johannesson, Henrik

    2017-01-01

    We consider a generalization of the quantum Rabi model where the two-level system and the single-mode cavity oscillator are coupled by an additional Stark-like term. By adapting a method recently introduced by Braak (2011 Phys. Rev. Lett . 107 100401), we solve the model exactly. The low-lying spectrum in the experimentally relevant ultrastrong and deep strong regimes of the Rabi coupling is found to exhibit two striking features absent from the original quantum Rabi model: avoided level crossings for states of the same parity and an anomalously rapid onset of two-fold near-degenerate levels as the Rabi coupling increases. (paper)

  7. The generalized Cauchy relation: a probe for local structure in materials with isotropic symmetry

    Energy Technology Data Exchange (ETDEWEB)

    Bactavatchalou, R [Laboratoire Europeen de Recherche Universitaire Saarland- Lorraine- Luxembourg at Universitaet des Saarlandes (Luxembourg); Alnot, P [Universite Henri Poincare, Nancy I (France); Bailer, J [Universite du Luxembourg (Luxembourg); Kolle, M [Laboratoire Europeen de Recherche Universitaire Saarland- Lorraine- Luxembourg at Universitaet des Saarlandes (Luxembourg); Mueller, U [Laboratoire Europeen de Recherche Universitaire Saarland- Lorraine- Luxembourg at Universitaet des Saarlandes (Luxembourg); Philipp, M [Laboratoire Europeen de Recherche Universitaire Saarland- Lorraine- Luxembourg at Universitaet des Saarlandes (Luxembourg); Possart, W [Laboratoire Europeen de Recherche Universitaire Saarland- Lorraine- Luxembourg at Universitaet des Saarlandes (Luxembourg); Rouxel, D [Universite Henri Poincare, Nancy I (France); Sanctuary, R [Universite du Luxembourg (Luxembourg); Tschoepe, A [Laboratoire Europeen de Recherche Universitaire Saarland- Lorraine- Luxembourg at Universitaet des Saarlandes (Luxembourg); Vergnat, Ch [Laboratoire Europeen de Recherche Universitaire Saarland- Lorraine- Luxembourg at Universitaet des Saarlandes (Luxembourg); Wetzel, B [Institut fuer Verbundwerkstoffe TU Kaiserslautern 67663 Kaiserslautern (Germany); Krueger, J K [Laboratoire Europeen de Recherche Universitaire Saarland- Lorraine- Luxembourg at Universitaet des Saarlandes (Luxembourg)

    2006-05-15

    The elastic properties of the isotropic state of condensed matter are given by the elastic constants ell and c44. In the liquid state the static shear stiffness c44 vanishes whereas at sufficient high probe frequencies a dynamic shear stiffness may appear. In that latter case the question about the existence of a Cauchy relation appears. It will be shown that a pure Cauchy relation can appear only under special conditions which are rarely fulfilled. For all investigated materials, including ceramics, liquids and glasses, a linear relation between ell and c44 called generalized Cauchy relation is observed, which, surprisingly, follows a linear transformation.

  8. A novel hierarchy of differential—integral equations and their generalized bi-Hamiltonian structures

    International Nuclear Information System (INIS)

    Zhai Yun-Yun; Geng Xian-Guo; He Guo-Liang

    2014-01-01

    With the aid of the zero-curvature equation, a novel integrable hierarchy of nonlinear evolution equations associated with a 3 × 3 matrix spectral problem is proposed. By using the trace identity, the bi-Hamiltonian structures of the hierarchy are established with two skew-symmetric operators. Based on two linear spectral problems, we obtain the infinite many conservation laws of the first member in the hierarchy

  9. A robust and general Schrödinger and Dirac solver for atomic structure calculations

    Czech Academy of Sciences Publication Activity Database

    Čertík, O.; Pask, J.E.; Vackář, Jiří

    2013-01-01

    Roč. 184, č. 7 (2013), s. 1777-1791 ISSN 0010-4655 R&D Projects: GA MŠk(CZ) LC06040; GA ČR GA101/09/1630 Institutional support: RVO:68378271 Keywords : atom * electronic structure * Dirac equation * density-functional theory Subject RIV: BE - Theoretical Physics Impact factor: 2.407, year: 2013 http://www.sciencedirect.com/science/article/pii/S0010465513000714

  10. Analysis of structural changes and characterization of general trends regarding product and technology policy

    OpenAIRE

    Stobbe, Lutz

    2010-01-01

    Abstract The identification of technology strategies is based on the assumption that large Japanese electro and electronics companies are pursuing similar strategies due to their comparable structures and the specific framework conditions they are facing in Japan. That does not mean however that the different companies have identical objectives in their product design or technology development. What it means is that the companies have a similar perception of the upcoming technology and man...

  11. A General Agent Model of Emotion and Trust using the BDI Structure

    OpenAIRE

    Höhle, Daniel

    2010-01-01

    To endow virtual agents with more human-like behaviour, the current project proposes a new model for decision making based on emotions and trust. The project focuses first on the conceptual design of the model, then on the implementation of this model. To try to reproduce human decision making, the model has, mostly, been based on psychologically grounded findings. This model is based on the BDI structure, and has been extended with submodels for emotions and trust. To further prove the imple...

  12. The DQ and DQΦ electronic structure diabatization methods: Validation for general applications

    Energy Technology Data Exchange (ETDEWEB)

    Hoyer, Chad E.; Parker, Kelsey; Gagliardi, Laura, E-mail: gagliard@umn.edu, E-mail: truhlar@umn.edu; Truhlar, Donald G., E-mail: gagliard@umn.edu, E-mail: truhlar@umn.edu [Department of Chemistry, Chemical Theory Center, and Minnesota Supercomputing Institute, University of Minnesota, 207 Pleasant St. SE, Minneapolis, Minnesota 55455-0431 (United States)

    2016-05-21

    We recently proposed the dipole-quadrupole (DQ) method for transforming adiabatic electronic states to diabatic states by using matrix elements of the dipole and quadrupole operators, and we applied the method to 3-state diabatizations of LiH and phenol. Here we extend the method to also include the electrostatic potential, and we call the resulting method the DQΦ method, which denotes the dipole–quadrupole–electrostatic-potential diabatization method. The electrostatic potential provides extra flexibility, and the goal of the present work is to test and illustrate the robustness of the methods for producing diabatic potential energy curves that tend to the adiabatic curves away from crossings and avoided crossings and are smooth in regions of crossings and avoided crossings. We illustrate the generality of the methods by an application to LiH with four states and by two-state diabatizations of HCl, (H{sub 2}){sub 2}, O{sub 3}, and the reaction Li + HF → LiF + H. We find that—if enough states are included—the DQ method does not have a significant dependence on the parameter weighting the quadrupole moment, and a geometry-independent value of 10 a{sub 0}{sup −2} is adequate in all cases tested. We also find that the addition of the electrostatic potential improves the diabatic potentials in some cases and provides an additional property useful for increasing the generality of the method for diabatization.

  13. An asymptotic homogenization model for smart 3D grid-reinforced composite structures with generally orthotropic constituents

    International Nuclear Information System (INIS)

    Hassan, E M; Kalamkarov, A L; Georgiades, A V; Challagulla, K S

    2009-01-01

    A comprehensive micromechanical model for smart 3D composite structures reinforced with a periodic grid of generally orthotropic cylindrical reinforcements that also exhibit piezoelectric behavior is developed. The original boundary value problem characterizing the piezothermoelastic behavior of these structures is decoupled into a set of three simpler unit cell problems dealing, separately, with the elastic, piezoelectric and thermal expansion characteristics of the smart composite. The technique used is that of asymptotic homogenization and the solution of the unit cell problems permits determination of the effective elastic, piezoelectric and thermal expansion coefficients. The general orthotropy of the constituent materials is very important from the practical viewpoint and makes the analysis much more complicated. Several examples of practical interest are used to illustrate the work including smart 3D composites with cubic and conical embedded grids as well as diagonally reinforced smart structures. It is also shown in this work that in the limiting particular case of 2D grid-reinforced structures with isotropic reinforcements our results converge to earlier published results

  14. Are PDF Documents Accessible?

    Directory of Open Access Journals (Sweden)

    Mireia Ribera Turró

    2008-09-01

    Full Text Available Adobe PDF is one of the most widely used formats in scientific communications and in administrative documents. In its latest versions it has incorporated structural tags and improvements that increase its level of accessibility. This article reviews the concept of accessibility in the reading of digital documents and evaluates the accessibility of PDF according to the most widely established standards.

  15. Out-of-hours service in rural areas. An observational study of accessibility, attitudes and quality standards among general practitioners in Iceland.

    Science.gov (United States)

    Olafsson, G; Sigurdsson, J A

    2000-06-01

    To examine the access, workload, duties, commitments and quality standards of primary care physicians (GPs) resulting from out-of-hours service. All GPs (n = 96) in rural Iceland. Answers to a postal survey. The participation rate was 80%. The GPs estimated that in 97% of the cases they could be contacted within 5 minutes in an emergency. Under usual circumstances (weather conditions) and within a distance of 10 km, 70% of them could reach the patient within 30 minutes of receiving the call. In severe weather conditions, 50% of the GPs in smaller districts (650-6000 inhabitants) estimated that it could take up to 5 hours or more to reach the patient (which could happen once a year). In the least populated districts, 84% of the GPs had to be on call 14 days or more per month. Serious emergencies (involving special training such as cardiac resuscitation or tracheal intubation) were relatively rare, and GPs expressed the necessity for regular refresher courses in such fields. Modern telecommunication networks guarantee good access to out-of-hours service. The workload and on-call duties are great and do not comply with European Union (EU) recommendations regarding minimal rest time. If GPs in rural areas are to be expected to provide frontline health care, including in severe emergency situations, regular training courses are needed.

  16. Can students learn clinical method in general practice? A randomised crossover trial based on objective structured clinical examinations.

    Science.gov (United States)

    Murray, E.; Jolly, B.; Modell, M.

    1997-01-01

    OBJECTIVE: To determine whether students acquired clinical skills as well in general practice as in hospital and whether there was any difference in the acquisition of specific skills in the two environments. DESIGN: Randomised crossover trial. SUBJECTS AND SETTING: Annual intake of first year clinical students at one medical school. INTERVENTION: A 10 week block of general internal medicine, one half taught in general practice, the other in hospital. Students started at random in one location and crossed over after five weeks. OUTCOME MEASURES: Students' performance in two equivalent nine station objective structured clinical examinations administered at the mid and end points of the block: a direct comparison of the two groups' performance at five weeks; analysis of covariance, using their first examination scores as a covariate, to determine students' relative improvement over the second five weeks of their attachment. RESULTS: 225 students rotated through the block; all took at least one examination and 208 (92%) took both. For the first half of the year there was no significant difference in the students' acquisition of clinical skills in the two environments; later, however, students taught in general practice improved slightly more than those taught in hospital (P = 0.007). CONCLUSIONS: Students can learn clinical skills as well in general practice as in hospital; more work is needed to clarify where specific skills, knowledge, and attitudes are best learnt to allow rational planning of the undergraduate curriculum. PMID:9361543

  17. The general atomic and molecular electronic structure system HONDO: Version 7.0

    International Nuclear Information System (INIS)

    Dupuis, M.; Watts, J.D.; Villar, H.O.; Hurst, G.J.B.

    1989-01-01

    We describe a computer program for ab initio quantum mechanical calculations of atomic and molecular wavefunctions and energies. Capabilities for the calculation of energy gradients and second derivatives with respect to nuclear coordinates are provided for several types of wavefunctions. Calculations of many molecular properties based on the electron density are possible. The program contains automated algorithms for the determination of equilibrium structures, saddle points, reaction pathways, vibrational spectra including infrared and Raman intensities. We illustrate the capabilities of the program by highlighting research problems recently investigated with the present program. (orig.)

  18. Fine- and hyperfine-structure effects in molecular photoionization. I. General theory and direct photoionization

    Energy Technology Data Exchange (ETDEWEB)

    Germann, Matthias; Willitsch, Stefan, E-mail: stefan.willitsch@unibas.ch [Department of Chemistry, University of Basel, Klingelbergstrasse 80, 4056 Basel (Switzerland)

    2016-07-28

    We develop a model for predicting fine- and hyperfine intensities in the direct photoionization of molecules based on the separability of electron and nuclear spin states from vibrational-electronic states. Using spherical tensor algebra, we derive highly symmetrized forms of the squared photoionization dipole matrix elements from which we derive the salient selection and propensity rules for fine- and hyperfine resolved photoionizing transitions. Our theoretical results are validated by the analysis of the fine-structure resolved photoelectron spectrum of O{sub 2} reported by Palm and Merkt [Phys. Rev. Lett. 81, 1385 (1998)] and are used for predicting hyperfine populations of molecular ions produced by photoionization.

  19. Fine- and hyperfine-structure effects in molecular photoionization. I. General theory and direct photoionization.

    Science.gov (United States)

    Germann, Matthias; Willitsch, Stefan

    2016-07-28

    We develop a model for predicting fine- and hyperfine intensities in the direct photoionization of molecules based on the separability of electron and nuclear spin states from vibrational-electronic states. Using spherical tensor algebra, we derive highly symmetrized forms of the squared photoionization dipole matrix elements from which we derive the salient selection and propensity rules for fine- and hyperfine resolved photoionizing transitions. Our theoretical results are validated by the analysis of the fine-structure resolved photoelectron spectrum of O2 reported by Palm and Merkt [Phys. Rev. Lett. 81, 1385 (1998)] and are used for predicting hyperfine populations of molecular ions produced by photoionization.

  20. Generalization of proposed tendon friction correlation and its application to PCCV structural analysis

    International Nuclear Information System (INIS)

    Kashiwase, Takako; Nagasaka, Hideo

    2000-01-01

    The present paper dealt with the extension of tendon friction coefficient correlation as a function of loading end load and circumferential angle, proposed in the former paper. The extended correlation further included the effects of the number of strands contacted with sheath, tendon diameter, politicization of tendon and tendon local curvature. The validity of the correlation was confirmed by several published measured data. The structural analysis of middle cylinder part of 1/4 PCCV (Prestressed Concrete Containment Vessel) model was conducted using the present friction coefficient correlation. The results were compared with the analysis using constant friction coefficient, focused on the tendon tension force distribution. (author)

  1. Extending the Online Public Access Catalog into the Microcomputer Environment.

    Science.gov (United States)

    Sutton, Brett

    1990-01-01

    Describes PCBIS, a database program for MS-DOS microcomputers that features a utility for automatically converting online public access catalog search results stored as text files into structured database files that can be searched, sorted, edited, and printed. Topics covered include the general features of the program, record structure, record…

  2. Emergence of a common generalized synchronization manifold in network motifs of structurally different time-delay systems

    International Nuclear Information System (INIS)

    Suresh, R.; Senthilkumar, D.V.; Lakshmanan, M.; Kurths, J.

    2016-01-01

    Highlights: • We have identified that a common generalized synchronization manifold exist for symmetrically coupled structurally different time-delay systems with different orders. • We have provided a theoretical formulation for the existence of a common generalized synchronization manifold based on the auxiliary system approach. • We have pointed out the existence of a transition from partial to global generalized synchronization. • We have corroborated our results using the maximal transverse Lyapunov exponent, correlation coefficient, mutual false nearest neighbor method. - Abstract: We point out the existence of a transition from partial to global generalized synchronization (GS) in symmetrically coupled structurally different time-delay systems of different orders using the auxiliary system approach and the mutual false nearest neighbor method. The present authors have recently reported that there exists a common GS manifold even in an ensemble of structurally nonidentical scalar time-delay systems with different fractal dimensions and shown that GS occurs simultaneously with phase synchronization (PS). In this paper we confirm that the above result is not confined just to scalar one-dimensional time-delay systems alone but there exists a similar type of transition even in the case of time-delay systems with different orders. We calculate the maximal transverse Lyapunov exponent to evaluate the asymptotic stability of the complete synchronization manifold of each of the main and the corresponding auxiliary systems, which in turn ensures the stability of the GS manifold between the main systems. Further we estimate the correlation coefficient and the correlation of probability of recurrence to establish the relation between GS and PS. We also calculate the mutual false nearest neighbor parameter which doubly confirms the occurrence of the global GS manifold.

  3. Representing general theoretical concepts in structural equation models: The role of composite variables

    Science.gov (United States)

    Grace, J.B.; Bollen, K.A.

    2008-01-01

    Structural equation modeling (SEM) holds the promise of providing natural scientists the capacity to evaluate complex multivariate hypotheses about ecological systems. Building on its predecessors, path analysis and factor analysis, SEM allows for the incorporation of both observed and unobserved (latent) variables into theoretically-based probabilistic models. In this paper we discuss the interface between theory and data in SEM and the use of an additional variable type, the composite. In simple terms, composite variables specify the influences of collections of other variables and can be helpful in modeling heterogeneous concepts of the sort commonly of interest to ecologists. While long recognized as a potentially important element of SEM, composite variables have received very limited use, in part because of a lack of theoretical consideration, but also because of difficulties that arise in parameter estimation when using conventional solution procedures. In this paper we present a framework for discussing composites and demonstrate how the use of partially-reduced-form models can help to overcome some of the parameter estimation and evaluation problems associated with models containing composites. Diagnostic procedures for evaluating the most appropriate and effective use of composites are illustrated with an example from the ecological literature. It is argued that an ability to incorporate composite variables into structural equation models may be particularly valuable in the study of natural systems, where concepts are frequently multifaceted and the influence of suites of variables are often of interest. ?? Springer Science+Business Media, LLC 2007.

  4. Covariant framework for a mass monopole as a field structure in general relativity

    International Nuclear Information System (INIS)

    Schleifer, N.

    1980-01-01

    We present a covariant framework for what is usually referred to as a mass monopole, by utilizing certain scalar invariants that are functions of the eigenvalues of the Riemann tensor. We thus bridge one of the theoretical gaps in the Einstein-Infeld-Hoffmann (EIH) derivation of the equations of motion of particles from the field equations: the lack of a covariant characterization of those aspects of a particle's structure which influence its motion. We have succeeded in giving a covariant framework for a mass monopole, which is the particle type assumed by EIH in their derivation. This is accomplished by using only the field outside the mass (singularity) to describe its characteristics, thereby conforming to a pure field description of nature. The utility of the framework has been verified by applying it to two physically relevant situations. The first is that of a Kerr particle, and the second is that of one spherically symmetric mass orbiting another. Our framework does indeed correspond to the intuitively expected results. In addition, our novel use of eigenvalues of the Riemann tensor appears to be a possible avenue of approach to the covariant characterization of other particle structure

  5. Time-sliced perturbation theory for large scale structure I: general formalism

    Energy Technology Data Exchange (ETDEWEB)

    Blas, Diego; Garny, Mathias; Sibiryakov, Sergey [Theory Division, CERN, CH-1211 Genève 23 (Switzerland); Ivanov, Mikhail M., E-mail: diego.blas@cern.ch, E-mail: mathias.garny@cern.ch, E-mail: mikhail.ivanov@cern.ch, E-mail: sergey.sibiryakov@cern.ch [FSB/ITP/LPPC, École Polytechnique Fédérale de Lausanne, CH-1015, Lausanne (Switzerland)

    2016-07-01

    We present a new analytic approach to describe large scale structure formation in the mildly non-linear regime. The central object of the method is the time-dependent probability distribution function generating correlators of the cosmological observables at a given moment of time. Expanding the distribution function around the Gaussian weight we formulate a perturbative technique to calculate non-linear corrections to cosmological correlators, similar to the diagrammatic expansion in a three-dimensional Euclidean quantum field theory, with time playing the role of an external parameter. For the physically relevant case of cold dark matter in an Einstein-de Sitter universe, the time evolution of the distribution function can be found exactly and is encapsulated by a time-dependent coupling constant controlling the perturbative expansion. We show that all building blocks of the expansion are free from spurious infrared enhanced contributions that plague the standard cosmological perturbation theory. This paves the way towards the systematic resummation of infrared effects in large scale structure formation. We also argue that the approach proposed here provides a natural framework to account for the influence of short-scale dynamics on larger scales along the lines of effective field theory.

  6. Estimating evolutionary rates using time-structured data: a general comparison of phylogenetic methods.

    Science.gov (United States)

    Duchêne, Sebastián; Geoghegan, Jemma L; Holmes, Edward C; Ho, Simon Y W

    2016-11-15

    In rapidly evolving pathogens, including viruses and some bacteria, genetic change can accumulate over short time-frames. Accordingly, their sampling times can be used to calibrate molecular clocks, allowing estimation of evolutionary rates. Methods for estimating rates from time-structured data vary in how they treat phylogenetic uncertainty and rate variation among lineages. We compiled 81 virus data sets and estimated nucleotide substitution rates using root-to-tip regression, least-squares dating and Bayesian inference. Although estimates from these three methods were often congruent, this largely relied on the choice of clock model. In particular, relaxed-clock models tended to produce higher rate estimates than methods that assume constant rates. Discrepancies in rate estimates were also associated with high among-lineage rate variation, and phylogenetic and temporal clustering. These results provide insights into the factors that affect the reliability of rate estimates from time-structured sequence data, emphasizing the importance of clock-model testing. sduchene@unimelb.edu.au or garzonsebastian@hotmail.comSupplementary information: Supplementary data are available at Bioinformatics online. © The Author 2016. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

  7. Support for a tax increase to provide unrestricted access to an Alzheimer's disease medication: a survey of the general public in Canada.

    Science.gov (United States)

    Oremus, Mark; Tarride, Jean-Eric; Clayton, Natasha; Raina, Parminder

    2009-12-29

    Public drug insurance plans provide limited reimbursement for Alzheimer's disease (AD) medications in many jurisdictions, including Canada and the United Kingdom. This study was conducted to assess Canadians' level of support for an increase in annual personal income taxes to fund a public program of unrestricted access to AD medications. A telephone survey was administered to a national sample of 500 adult Canadians. The survey contained four scenarios describing a hypothetical, new AD medication. Descriptions varied across scenarios: the medication was alternatively described as being capable of treating the symptoms of cognitive decline or of halting the progression of cognitive decline, with either no probability of adverse effects or a 30% probability of primarily gastrointestinal adverse effects. After each scenario, participants were asked whether they would support a tax increase to provide unrestricted access to the drug. Participants who responded affirmatively were asked whether they would pay an additional $75, $150, or $225 per annum in taxes. Multivariable logistic regression analysis was conducted to examine the determinants of support for a tax increase. Eighty percent of participants supported a tax increase for at least one scenario. Support was highest (67%) for the most favourable scenario (halt progression - no adverse effects) and lowest (49%) for the least favourable scenario (symptom treatment - 30% chance of adverse effects). The odds of supporting a tax increase under at least one scenario were approximately 55% less for participants who attached higher ratings to their health state under the assumption that they had moderate AD and almost five times greater if participants thought family members or friends would somewhat or strongly approve of their decision to support a tax increase. A majority of participants would pay an additional $150 per annum in taxes, regardless of scenario. Less than 50% would pay $225. Four out of five persons

  8. Event representations constrain the structure of language: Sign language as a window into universally accessible linguistic biases.

    Science.gov (United States)

    Strickland, Brent; Geraci, Carlo; Chemla, Emmanuel; Schlenker, Philippe; Kelepir, Meltem; Pfau, Roland

    2015-05-12

    According to a theoretical tradition dating back to Aristotle, verbs can be classified into two broad categories. Telic verbs (e.g., "decide," "sell," "die") encode a logical endpoint, whereas atelic verbs (e.g., "think," "negotiate," "run") do not, and the denoted event could therefore logically continue indefinitely. Here we show that sign languages encode telicity in a seemingly universal way and moreover that even nonsigners lacking any prior experience with sign language understand these encodings. In experiments 1-5, nonsigning English speakers accurately distinguished between telic (e.g., "decide") and atelic (e.g., "think") signs from (the historically unrelated) Italian Sign Language, Sign Language of the Netherlands, and Turkish Sign Language. These results were not due to participants' inferring that the sign merely imitated the action in question. In experiment 6, we used pseudosigns to show that the presence of a salient visual boundary at the end of a gesture was sufficient to elicit telic interpretations, whereas repeated movement without salient boundaries elicited atelic interpretations. Experiments 7-10 confirmed that these visual cues were used by all of the sign languages studied here. Together, these results suggest that signers and nonsigners share universally accessible notions of telicity as well as universally accessible "mapping biases" between telicity and visual form.

  9. Wireless Access

    Indian Academy of Sciences (India)

    First page Back Continue Last page Overview Graphics. Wireless Access. Wireless connect to the Base station. Easy and Convenient access. Costlier as compared to the wired technology. Reliability challenges. We see it as a complementary technology to the DSL.

  10. Time-Sliced Perturbation Theory for Large Scale Structure I: General Formalism

    CERN Document Server

    Blas, Diego; Ivanov, Mikhail M.; Sibiryakov, Sergey

    2016-01-01

    We present a new analytic approach to describe large scale structure formation in the mildly non-linear regime. The central object of the method is the time-dependent probability distribution function generating correlators of the cosmological observables at a given moment of time. Expanding the distribution function around the Gaussian weight we formulate a perturbative technique to calculate non-linear corrections to cosmological correlators, similar to the diagrammatic expansion in a three-dimensional Euclidean quantum field theory, with time playing the role of an external parameter. For the physically relevant case of cold dark matter in an Einstein--de Sitter universe, the time evolution of the distribution function can be found exactly and is encapsulated by a time-dependent coupling constant controlling the perturbative expansion. We show that all building blocks of the expansion are free from spurious infrared enhanced contributions that plague the standard cosmological perturbation theory. This pave...

  11. Pathways to care and psychological problems of general practice patients in a "gate keeper" and an "open access" health care system - A comparison of Germany and the Netherlands

    NARCIS (Netherlands)

    Linden, M; Gothe, H; Ormel, J

    2003-01-01

    Background The comparison of different health care systems is one way to give empirical evidence to health care reform and policy. The differences between health care systems in which general practitioners serve as gate keepers in comparison to systems in which patients are free to contact every

  12. Making ATLAS Data from CERN Accessible to the General Public: The Development and Evaluation of a Learning Resource in Experimental Particle Physics

    CERN Document Server

    AUTHOR|(CDS)2243922; Ekelin, Svea Magdalena; Lund-Jensen, Bengt; Christiansen, Iben

    2017-08-15

    In 2016, the ATLAS experiment at CERN released data from 100 trillion proton-proton collisions to the general public. In connection to this release the ATLAS Outreach group has developed several tools for visualizing and analyzing the data, one of which is a Histogram analyzer. The focus of this project is to bridge the gap between the general public's knowledge in physics and what is needed to use this Histogram analyzer. The project consists of both the development and an evaluation of a learning resource that explains experimental particle physics for a general public audience. The learning resource is a website making use of analogies and two perspectives on learning: Variation Theory and Cognitive Load Theory. The evaluation of the website was done using a survey with 10 respondents and it focused on whether analogies and the perspectives on learning helped their understanding. In general the respondents found the analogies to be helpful for their learning, and to some degree they found the explanations ...

  13. Structures of the human Pals1 PDZ domain with and without ligand suggest gated access of Crb to the PDZ peptide-binding groove

    Energy Technology Data Exchange (ETDEWEB)

    Ivanova, Marina E.; Fletcher, Georgina C.; O’Reilly, Nicola; Purkiss, Andrew G.; Thompson, Barry J. [Cancer Research UK, 44 Lincoln’s Inn Fields, London WC2A 3LY (United Kingdom); McDonald, Neil Q., E-mail: neil.mcdonald@cancer.org.uk [Cancer Research UK, 44 Lincoln’s Inn Fields, London WC2A 3LY (United Kingdom); Birkbeck College, University of London, Malet Street, London WC1E 7HX (United Kingdom)

    2015-03-01

    This study characterizes the interaction between the carboxy-terminal (ERLI) motif of the essential polarity protein Crb and the Pals1/Stardust PDZ-domain protein. Structures of human Pals1 PDZ with and without a Crb peptide are described, explaining the highly conserved nature of the ERLI motif and revealing a sterically blocked peptide-binding groove in the absence of ligand. Many components of epithelial polarity protein complexes possess PDZ domains that are required for protein interaction and recruitment to the apical plasma membrane. Apical localization of the Crumbs (Crb) transmembrane protein requires a PDZ-mediated interaction with Pals1 (protein-associated with Lin7, Stardust, MPP5), a member of the p55 family of membrane-associated guanylate kinases (MAGUKs). This study describes the molecular interaction between the Crb carboxy-terminal motif (ERLI), which is required for Drosophila cell polarity, and the Pals1 PDZ domain using crystallography and fluorescence polarization. Only the last four Crb residues contribute to Pals1 PDZ-domain binding affinity, with specificity contributed by conserved charged interactions. Comparison of the Crb-bound Pals1 PDZ structure with an apo Pals1 structure reveals a key Phe side chain that gates access to the PDZ peptide-binding groove. Removal of this side chain enhances the binding affinity by more than fivefold, suggesting that access of Crb to Pals1 may be regulated by intradomain contacts or by protein–protein interaction.

  14. Open access

    NARCIS (Netherlands)

    Valkenburg, P.M.

    2015-01-01

    Open access week Van 19 tot en met 25 oktober 2015 vond wereldwijd de Open Access Week plaats. Tijdens deze week werden er over de hele wereld evenementen georganiseerd waar open access een rol speelt. Ook in Nederland zijn er diverse symposia, workshops en debatten georganiseerd zoals het debat in

  15. Generalized social anxiety disorder and avoidant personality disorder: structural analysis and treatment outcome.

    Science.gov (United States)

    Huppert, Jonathan D; Strunk, Daniel R; Ledley, Deborah Roth; Davidson, Jonathan R T; Foa, Edna B

    2008-01-01

    There has been considerable controversy about whether generalized social phobia (GSP) and avoidant personality disorder (APD) are redundant diagnostic categories. In light of the ongoing controversy, more data are needed to help determine whether GSP and APD are independent constructs. Data were obtained from 335 people seeking treatment for GSP at a two site clinical trial. Indicators of GSP and APD were obtained along with assessments of demographic factors, level of functioning, and indicators of related psychopathology. Confirmatory factor analyses of indicators of GSP and APD suggested a somewhat better fit for a two-factor solution. Comparisons of GSP patients with and without APD suggested that in addition to having more severe social phobia symptoms, patients with APD were more depressed on a self-report measure and had more functional impairment, thereby suggesting potential utility of the diagnostic category of APD. Furthermore, the presence of APD predicted treatment response, in that patients with APD had more change early in treatment than those without APD. APD and GSP remain highly related constructs, and different aspects of these data support and dispute the utility of the diagnosis of APD in GSP. Possible new directions in conceptualizing APD are discussed. Published 2007 Wiley-Liss, Inc.

  16. Structure of general-population antibody titer distributions to influenza A virus.

    Science.gov (United States)

    Nhat, Nguyen Thi Duy; Todd, Stacy; de Bruin, Erwin; Thao, Tran Thi Nhu; Vy, Nguyen Ha Thao; Quan, Tran Minh; Vinh, Dao Nguyen; van Beek, Janko; Anh, Pham Hong; Lam, Ha Minh; Hung, Nguyen Thanh; Thanh, Nguyen Thi Le; Huy, Huynh Le Anh; Ha, Vo Thi Hong; Baker, Stephen; Thwaites, Guy E; Lien, Nguyen Thi Nam; Hong, Tran Thi Kim; Farrar, Jeremy; Simmons, Cameron P; Chau, Nguyen Van Vinh; Koopmans, Marion; Boni, Maciej F

    2017-07-20

    Seroepidemiological studies aim to understand population-level exposure and immunity to infectious diseases. Their results are normally presented as binary outcomes describing the presence or absence of pathogen-specific antibody, despite the fact that many assays measure continuous quantities. A population's natural distribution of antibody titers to an endemic infectious disease may include information on multiple serological states - naiveté, recent infection, non-recent infection, childhood infection - depending on the disease in question and the acquisition and waning patterns of immunity. In this study, we investigate 20,152 general-population serum samples from southern Vietnam collected between 2009 and 2013 from which we report antibody titers to the influenza virus HA1 protein using a continuous titer measurement from a protein microarray assay. We describe the distributions of antibody titers to subtypes 2009 H1N1 and H3N2. Using a model selection approach to fit mixture distributions, we show that 2009 H1N1 antibody titers fall into four titer subgroups and that H3N2 titers fall into three subgroups. For H1N1, our interpretation is that the two highest-titer subgroups correspond to recent and historical infection, which is consistent with 2009 pandemic attack rates. Similar interpretations are available for H3N2, but right-censoring of titers makes these interpretations difficult to validate.

  17. Olfactory discrimination and generalization of ammonium nitrate and structurally related odorants in Labrador retrievers.

    Science.gov (United States)

    Lazarowski, Lucia; Foster, Melanie L; Gruen, Margaret E; Sherman, Barbara L; Fish, Richard E; Milgram, Norton W; Dorman, David C

    2015-11-01

    A critical aspect of canine explosive detection involves the animal's ability respond to novel, untrained odors based on prior experience with training odors. In the current study, adult Labrador retrievers (N = 15) were initially trained to discriminate between a rewarded odor (vanillin) and an unrewarded odor (ethanol) by manipulating scented objects with their nose in order to receive a food reward using a canine-adapted discrimination training apparatus. All dogs successfully learned this olfactory discrimination task (≥80 % correct in a mean of 296 trials). Next, dogs were trained on an ammonium nitrate (AN, NH4NO3) olfactory discrimination task [acquired in 60-240 trials, with a mean (±SEM) number of trials to criterion of 120.0 ± 15.6] and then tested for their ability to respond to untrained ammonium- and/or nitrate-containing chemicals as well as variants of AN compounds. Dogs did not respond to sodium nitrate or ammonium sulfate compounds at rates significantly higher than chance (58.8 ± 4.5 and 57.7 ± 3.3 % correct, respectively). Transfer performance to fertilizer-grade AN, AN mixed in Iraqi soil, and AN and flaked aluminum was significantly higher than chance (66.7 ± 3.2, 73.3 ± 4.0, 68.9 ± 4.0 % correct, respectively); however, substantial individual differences were observed. Only 53, 60, and 64 % of dogs had a correct response rate with fertilizer-grade AN, AN and Iraqi soil, and AN and flaked aluminum, respectively, that were greater than chance. Our results suggest that dogs do not readily generalize from AN to similar AN-based odorants at reliable levels desired for explosive detection dogs and that performance varies significantly within Labrador retrievers selected for an explosive detection program.

  18. Structure, Quaternary history, and general geology of the Corral Canyon area, Los Angeles County, California

    Science.gov (United States)

    Yerkes, R.F.; Wentworth, Carl M.

    1965-01-01

    The Corral Canyon nuclear power plant site consists of about 305 acres near the mouth of Corral Canyon in the central Santa Monica Mountains; it is located on an east-trending segment of the Pacific Coast between Point Dume and Malibu Canyon, about 28 miles due west of Los Angeles. The Santa Monica Mountains are the southwesternmost mainland part of the Transverse Ranges province, the east-trending features of which transect the otherwise relatively uniform northwesterly trend of the geomorphic and geologic features of coastal California. The south margin of the Transverse Ranges is marked by the Santa Monica fault system, which extends eastward near the 34th parallel for at least 145 miles from near Santa Cruz Island to the San Andreas fault zone. In the central Santa Monica Mountains area the Santa Monica fault system includes the Malibu Coast fault and Malibu Coast zone of deformation on the north; from the south it includes an inferred fault--the Anacapa fault--considered to follow an east-trending topographic escarpmemt on the sea floor about 5 miles south of the Malibu Coast fault. The low-lying terrain south of the fault system, including the Los Angeles basin and the largely submerged Continental Borderland offshore, are dominated by northwest-trending structural features. The Malibu Coat zone is a wide, east-trending band of asymmetrically folded, sheared, and faulted bedrock that extends for more than 20 miles along the north margin of the Santa Monica fault system west of Santa Monica. Near the north margin of the Malibu Coast zone the north-dipping, east-trending Malibu Coast fault juxtaposes unlike, in part contemporaneous sedimentary rock sections; it is inferred to be the near-surface expression of a major crustal boundary between completely unrelated basement rocks. Comparison of contemporaneous structural features and stratigraphic sections (Late Cretaceous to middle Miocene sedimentary, rocks and middle Miocene volcanic and intrusive igneous rocks

  19. General exact harmonic analysis of in-plane timoshenko beam structures

    Directory of Open Access Journals (Sweden)

    C. A. N. Dias

    Full Text Available The exact solution for the problem of damped, steady state response, of in-plane Timoshenko frames subjected to harmonically time varying external forces is here described. The solution is obtained by using the classical dynamic stiffness matrix (DSM, which is non-linear and transcendental in respect to the excitation frequency, and by performing the harmonic analysis using the Laplace transform. As an original contribution, the partial differential coupled governing equations, combining displacements and forces, are directly subjected to Laplace transforms, leading to the member DSM and to the equivalent load vector formulations. Additionally, the members may have rigid bodies attached at any of their ends where, optionally, internal forces can be released. The member matrices are then used to establish the global matrices that represent the dynamic equilibrium of the overall framed structure, preserving close similarity to the finite element method. Several application examples prove the certainty of the proposed method by comparing the model results with the ones available in the literature or with finite element analyses.

  20. An Asset Pricing Approach to Testing General Term Structure Models including Heath-Jarrow-Morton Specifications and Affine Subclasses

    DEFF Research Database (Denmark)

    Christensen, Bent Jesper; van der Wel, Michel

    of the risk premium is associated with the slope factor, and individual risk prices depend on own past values, factor realizations, and past values of other risk prices, and are significantly related to the output gap, consumption, and the equity risk price. The absence of arbitrage opportunities is strongly...... is tested, but in addition to the standard bilinear term in factor loadings and market prices of risk, the relevant mean restriction in the term structure case involves an additional nonlinear (quadratic) term in factor loadings. We estimate our general model using likelihood-based dynamic factor model...... techniques for a variety of volatility factors, and implement the relevant likelihood ratio tests. Our factor model estimates are similar across a general state space implementation and an alternative robust two-step principal components approach. The evidence favors time-varying market prices of risk. Most...

  1. General method of preparation of uniformly 13C, 15N-labeled DNA fragments for NMR analysis of DNA structures

    International Nuclear Information System (INIS)

    Rene, Brigitte; Masliah, Gregoire; Zargarian, Loussine; Mauffret, Olivier; Fermandjian, Serge

    2006-01-01

    Summary 13 C, 15 N labeling of biomolecules allows easier assignments of NMR resonances and provides a larger number of NMR parameters, which greatly improves the quality of DNA structures. However, there is no general DNA-labeling procedure, like those employed for proteins and RNAs. Here, we describe a general and widely applicable approach designed for preparation of isotopically labeled DNA fragments that can be used for NMR studies. The procedure is based on the PCR amplification of oligonucleotides in the presence of labeled deoxynucleotides triphosphates. It allows great flexibility thanks to insertion of a short DNA sequence (linker) between two repeats of DNA sequence to study. Size and sequence of the linker are designed as to create restriction sites at the junctions with DNA of interest. DNA duplex with desired sequence and size is released upon enzymatic digestion of the PCR product. The suitability of the procedure is validated through the preparation of two biological relevant DNA fragments

  2. Time dependent accessibility

    OpenAIRE

    Kaza, Nikhil

    2015-01-01

    Many place based accessibility studies ignore the time component. Relying on theoretical frameworks that treat distance between two fixed points as constant, these methods ignore the diurnal and seasonal changes in accessibility. Network distances between two nodes are dependent on the network structure and weight distribution on the edges. These weights can change quite frequently and the network structure itself is subject to modification because of availability and unavailability of links ...

  3. Contribution to the study of metal-oxide-semiconductor devices with optical access. In2O3-SiO2-Si structure

    International Nuclear Information System (INIS)

    Thenoz, Yves.

    1974-01-01

    A general study of the fabrication of the structure In 2 O 3 /SiO 2 /Si was made encompassing the problems posed during the realization of these structures. The sputtering study enabled the influence of the main parameters on layer properties to be determined. The decisive importance of clean conditions throughout fabrication (especially during sputtering) on the properties of In 2 O 3 layers and on those of the structure and its stability was revealed. However, the problem of ageing of the structure were not investigated. Finally, the construction of MOS capacitors and transistors showed that In 2 O 3 /SiO 2 /Si structures can be used in MOS circuits [fr

  4. Decay constants of pseudoscalar mesons in Bethe–Salpeter framework with generalized structure of hadron-quark vertex

    International Nuclear Information System (INIS)

    Bhatnagar, Shashank; Li, Shiyuan

    2009-01-01

    We employ the framework of Bethe–Salpeter equation under Covariant Instantaneous Ansatz to study the leptonic decays of pseudoscalar mesons. The Dirac structure of hadron-quark vertex function Γ is generalized to include various Dirac covariants besides γ5 from their complete set. The covariants are incorporated in accordance with a power counting rule, order-by-order in powers of the inverse of the meson mass. The decay constants are calculated with the incorporation of leading order covariants. Most of the results are dramatically improved. (author)

  5. Structural changes and conductance thresholds in metal-free intrinsic SiOx resistive random access memory

    International Nuclear Information System (INIS)

    Mehonic, Adnan; Buckwell, Mark; Montesi, Luca; Garnett, Leon; Hudziak, Stephen; Kenyon, Anthony J.; Fearn, Sarah; Chater, Richard; McPhail, David

    2015-01-01

    We present an investigation of structural changes in silicon-rich silicon oxide metal-insulator-metal resistive RAM devices. The observed unipolar switching, which is intrinsic to the bulk oxide material and does not involve movement of metal ions, correlates with changes in the structure of the oxide. We use atomic force microscopy, conductive atomic force microscopy, x-ray photoelectron spectroscopy, and secondary ion mass spectroscopy to examine the structural changes occurring as a result of switching. We confirm that protrusions formed at the surface of samples during switching are bubbles, which are likely to be related to the outdiffusion of oxygen. This supports existing models for valence-change based resistive switching in oxides. In addition, we describe parallel linear and nonlinear conduction pathways and suggest that the conductance quantum, G 0 , is a natural boundary between the high and low resistance states of our devices

  6. Structural changes and conductance thresholds in metal-free intrinsic SiOx resistive random access memory

    Science.gov (United States)

    Mehonic, Adnan; Buckwell, Mark; Montesi, Luca; Garnett, Leon; Hudziak, Stephen; Fearn, Sarah; Chater, Richard; McPhail, David; Kenyon, Anthony J.

    2015-03-01

    We present an investigation of structural changes in silicon-rich silicon oxide metal-insulator-metal resistive RAM devices. The observed unipolar switching, which is intrinsic to the bulk oxide material and does not involve movement of metal ions, correlates with changes in the structure of the oxide. We use atomic force microscopy, conductive atomic force microscopy, x-ray photoelectron spectroscopy, and secondary ion mass spectroscopy to examine the structural changes occurring as a result of switching. We confirm that protrusions formed at the surface of samples during switching are bubbles, which are likely to be related to the outdiffusion of oxygen. This supports existing models for valence-change based resistive switching in oxides. In addition, we describe parallel linear and nonlinear conduction pathways and suggest that the conductance quantum, G0, is a natural boundary between the high and low resistance states of our devices.

  7. Structural changes and conductance thresholds in metal-free intrinsic SiO{sub x} resistive random access memory

    Energy Technology Data Exchange (ETDEWEB)

    Mehonic, Adnan, E-mail: a.mehonic@ee.ucl.ac.uk, E-mail: t.kenyon@ucl.ac.uk; Buckwell, Mark; Montesi, Luca; Garnett, Leon; Hudziak, Stephen; Kenyon, Anthony J., E-mail: a.mehonic@ee.ucl.ac.uk, E-mail: t.kenyon@ucl.ac.uk [Department of Electronic and Electrical Engineering, UCL, Torrington Place, London WC1E 7JE (United Kingdom); Fearn, Sarah; Chater, Richard; McPhail, David [Department of Materials, Imperial College London, South Kensington Campus, London SW7 2AZ (United Kingdom)

    2015-03-28

    We present an investigation of structural changes in silicon-rich silicon oxide metal-insulator-metal resistive RAM devices. The observed unipolar switching, which is intrinsic to the bulk oxide material and does not involve movement of metal ions, correlates with changes in the structure of the oxide. We use atomic force microscopy, conductive atomic force microscopy, x-ray photoelectron spectroscopy, and secondary ion mass spectroscopy to examine the structural changes occurring as a result of switching. We confirm that protrusions formed at the surface of samples during switching are bubbles, which are likely to be related to the outdiffusion of oxygen. This supports existing models for valence-change based resistive switching in oxides. In addition, we describe parallel linear and nonlinear conduction pathways and suggest that the conductance quantum, G{sub 0}, is a natural boundary between the high and low resistance states of our devices.

  8. Generalized non-Local Resistance Expression and its Application in F/N/F Spintronic Structure with Graphene Channel

    Science.gov (United States)

    Wei, Huazhou; Fu, Shiwei

    We report our work on the spin transport properties in the F/N/F(ferromagnets/normal metal/ferromagnets) spintronic structure from a new theoretical perspective. A significant problem in the field is to explain the inferior measured order of magnitude for spin lifetime. Based on the known non-local resistance formula and the mechanism analysis of spin-flipping within the interfaces between F and N, we analytically derive a broadly applicable new non-local resistance expression and a generalized Hanle curve formula. After employing them in the F/N/F structure under different limits, especially in the case of graphene channel, we find that the fitting from experimental data would yield a longer spin lifetime, which approaches its theoretical predicted value in graphene. The authors acknowledge the financial support by China University of Petroleum-Beijing and the Key Laboratory of Optical Detection Technology for Oil and Gas in this institution.

  9. Chaos control and generalized projective synchronization of heavy symmetric chaotic gyroscope systems via Gaussian radial basis adaptive variable structure control

    International Nuclear Information System (INIS)

    Farivar, Faezeh; Aliyari Shoorehdeli, Mahdi; Nekoui, Mohammad Ali; Teshnehlab, Mohammad

    2012-01-01

    Highlights: ► A systematic procedure for GPS of unknown heavy chaotic gyroscope systems. ► Proposed methods are based on Lyapunov stability theory. ► Without calculating Lyapunov exponents and Eigen values of the Jacobian matrix. ► Capable to extend for a variety of chaotic systems. ► Useful for practical applications in the future. - Abstract: This paper proposes the chaos control and the generalized projective synchronization methods for heavy symmetric gyroscope systems via Gaussian radial basis adaptive variable structure control. Because of the nonlinear terms of the gyroscope system, the system exhibits chaotic motions. Occasionally, the extreme sensitivity to initial states in a system operating in chaotic mode can be very destructive to the system because of unpredictable behavior. In order to improve the performance of a dynamic system or avoid the chaotic phenomena, it is necessary to control a chaotic system with a periodic motion beneficial for working with a particular condition. As chaotic signals are usually broadband and noise like, synchronized chaotic systems can be used as cipher generators for secure communication. This paper presents chaos synchronization of two identical chaotic motions of symmetric gyroscopes. In this paper, the switching surfaces are adopted to ensure the stability of the error dynamics in variable structure control. Using the neural variable structure control technique, control laws are established which guarantees the chaos control and the generalized projective synchronization of unknown gyroscope systems. In the neural variable structure control, Gaussian radial basis functions are utilized to on-line estimate the system dynamic functions. Also, the adaptation laws of the on-line estimator are derived in the sense of Lyapunov function. Thus, the unknown gyro systems can be guaranteed to be asymptotically stable. Also, the proposed method can achieve the control objectives. Numerical simulations are presented to

  10. Evaluation of Fire Resistance for H-Section Columns Made of Rolled Steels for General Structures and for Welded Structures by Analytic Method

    International Nuclear Information System (INIS)

    Kwon, In-Kyu

    2014-01-01

    Fire resistance is an important factor in sustaining the structural stability of steel framed buildings on fire. However, evaluation of the fire resistance of steel columns has been conducted using rolled steels for general structures, SS 400. Recently, rolled steels for welded structures, such as SM 400 and SM 490, have been used frequently because they have better performance of welding than the SS 400. However, there has been doubt about how much fire resistance SM 400 and SM 490 have. To evaluate by calculation the fire resistance of an H-section column made of SS 400 its mechanical and thermal properties were derived and suggested respectively in the form of regressive equations and the analysis was done based on heat transfer and thermal stress analysis. In this study, the results of the evaluation of H-section columns made of SS 400 with loaded fire tests turned out to be conservative. As a result, a new guideline is required to get the exact fire resistance of another structural steel.

  11. RNA FRABASE 2.0: an advanced web-accessible database with the capacity to search the three-dimensional fragments within RNA structures

    Directory of Open Access Journals (Sweden)

    Wasik Szymon

    2010-05-01

    Full Text Available Abstract Background Recent discoveries concerning novel functions of RNA, such as RNA interference, have contributed towards the growing importance of the field. In this respect, a deeper knowledge of complex three-dimensional RNA structures is essential to understand their new biological functions. A number of bioinformatic tools have been proposed to explore two major structural databases (PDB, NDB in order to analyze various aspects of RNA tertiary structures. One of these tools is RNA FRABASE 1.0, the first web-accessible database with an engine for automatic search of 3D fragments within PDB-derived RNA structures. This search is based upon the user-defined RNA secondary structure pattern. In this paper, we present and discuss RNA FRABASE 2.0. This second version of the system represents a major extension of this tool in terms of providing new data and a wide spectrum of novel functionalities. An intuitionally operated web server platform enables very fast user-tailored search of three-dimensional RNA fragments, their multi-parameter conformational analysis and visualization. Description RNA FRABASE 2.0 has stored information on 1565 PDB-deposited RNA structures, including all NMR models. The RNA FRABASE 2.0 search engine algorithms operate on the database of the RNA sequences and the new library of RNA secondary structures, coded in the dot-bracket format extended to hold multi-stranded structures and to cover residues whose coordinates are missing in the PDB files. The library of RNA secondary structures (and their graphics is made available. A high level of efficiency of the 3D search has been achieved by introducing novel tools to formulate advanced searching patterns and to screen highly populated tertiary structure elements. RNA FRABASE 2.0 also stores data and conformational parameters in order to provide "on the spot" structural filters to explore the three-dimensional RNA structures. An instant visualization of the 3D RNA

  12. Barriers to Maori sole mothers’ primary health care access

    Directory of Open Access Journals (Sweden)

    Lee R

    2013-12-01

    Full Text Available INTRODUCTION: International research consistently shows that sole mothers experience poorer health and suboptimal health care access. New Zealand studies on sole mothers' health report similar findings. The aim of this exploratory research was to better understand the experiences of Maori sole mothers' access to health services, particularly primary health care, for personal health needs. METHODS: This qualitative study employed a general inductive design informed by a Kaupapa Maori approach, providing guidance on appropriate cultural protocols for recruiting and engaging Maori participants. Distributing written information and snowballing techniques were used to purposively recruit seven Maori sole mothers. Data collection involved semi-structured interviews which were digitally recorded and transcribed verbatim. Data were analysed using general inductive thematic analysis to identify commonalities and patterns in participants' experiences. FINDINGS: The dominant themes that emerged captured and described participants' experiences in accessing health care. The major barrier to access reported was cost. Compounding cost, transport difficulties and location or scheduling of services were additional barriers to health service accessibility. Child-related issues also posed a barrier, including prioritising children's needs and childcare over personal health needs. CONCLUSION: The findings illuminate Maori sole mothers' experiences of accessing health care and the complex socioeconomic inequalities affecting access options and uptake of services. Further investigation of barriers to access is needed. The study has implications for addressing barriers to access at policy, funding and practice levels to improve health outcomes and equitable health care access for Maori sole mothers.

  13. Testing the importance of family solidarity, community structure, information access, and social capital in predicting nutrition health knowledge and food choices in the Philippines.

    Science.gov (United States)

    Moxley, Robert L; Jicha, Karl A; Thompson, Gretchen H

    2011-01-01

    This study investigates the influence of family solidarity, community structure, information access, social capital, and socioeconomic status on the extent of nutrition and health knowledge (NHK) among primary household meal planners. In turn, we pose the question: does this knowledge influence dietary decision making? Data are taken from a survey determining socioeconomic impacts of vitamin A fortified peanut butter on Philippine households. Questions on the relationships of nutrition to health were selected to construct a knowledge index on which household respondents could be ranked. We then tested hypotheses regarding what types of individual, family-level, and community structural characteristics would predict performance on this index. The results indicate that the strongest predictors of NHK come from sociological theory related to family solidarity and community centrality, in addition to information accessibility and household income. Our findings also indicate that NHK influences dietary choices with regard to the purchase of a vitamin fortified staple food product, which is essential when addressing nutritional deficiency problems in developing countries.

  14. Power Flow Calculation for Weakly Meshed Distribution Networks with Multiple DGs Based on Generalized Chain-table Storage Structure

    DEFF Research Database (Denmark)

    Chen, Shuheng; Hu, Weihao; Chen, Zhe

    2014-01-01

    Based on generalized chain-table storage structure (GCTSS), a novel power flow method is proposed, which can be used to solve the power flow of weakly meshed distribution networks with multiple distributed generators (DGs). GCTSS is designed based on chain-table technology and its target is to de......Based on generalized chain-table storage structure (GCTSS), a novel power flow method is proposed, which can be used to solve the power flow of weakly meshed distribution networks with multiple distributed generators (DGs). GCTSS is designed based on chain-table technology and its target...... is to describe the topology of radial distribution networks with a clear logic and a small memory size. The strategies of compensating the equivalent currents of break-point branches and the reactive power outputs of PV-type DGs are presented on the basis of superposition theorem. Their formulations...... are simplified to be the final multi-variable linear functions. Furthermore, an accelerating factor is applied to the outer-layer reactive power compensation for improving the convergence procedure. Finally, the proposed power flow method is performed in program language VC++ 6.0, and numerical tests have been...

  15. THE DEVELOPMENT OF THE ACCESS TO THE LABOR MARKET THROUGH THE IMPROVEMENT OF THE MECHANISMS OF STRUCTURAL FUNDS GRANTING

    Directory of Open Access Journals (Sweden)

    EMILIAN M. DOBRESCU

    2012-12-01

    Full Text Available As a consequence of the defective management of the European funds, the European Commission has adopted measures to improve the instruments of financial control and to reduce the errors that can lead to incorrect requests of payments from the European Union`s budget. In this work we attempt to identify aspects regarding the way to efficiently manage the structural funds for the member states and not only to implement and absorb them.

  16. Implementing structured functional assessments in general practice for persons with long-term sick leave: a cluster randomised controlled trial

    Directory of Open Access Journals (Sweden)

    Benth Jūratė

    2009-05-01

    Full Text Available Abstract Background The increasing attention on functional assessments in medical and vocational rehabilitation requires a focus change for the general practitioners (GP into paying attention to patient resources, possibilities and coping instead of symptoms, problems and limitations. The GPs report difficulties in performing the requested explicit functional assessments. The purpose of this study was to implement a structured method in general practice for assessing functional ability in persons with long-term sick leave. The study aim was to evaluate intervention effects on important GP parameters; knowledge, attitudes, self-efficacy towards functional assessments and knowledge about patient work factors. Methods Fifty-seven GPs were randomly assigned to an intervention or a control group. The intervention group GPs attended an introductory one-day work-shop and implemented structured functional assessments during an eight months intervention period. GP knowledge, GP attitudes, and GP self-efficacy towards functional assessments, as well as GP knowledge of patient work factors, were collected before, after and six months after the intervention period started. Evaluation score-sheets were filled in by both the intervention GPs and their patients immediately after the consultation to evaluate the GPs' knowledge of patient work factors. Results The intervention GPs reported increased knowledge (B: 0.56, 95% CI (0.19, 0.91 and self-efficacy (B: 0.90, 95% CI (0.53, 1.26 towards functional assessments, and increased knowledge about their patients' workplace (B: 0.75, 95% CI (0.35, 1.15 and perceived stressors (B: 0.55, 95% CI (0.23, 0.88 with lasting effects at the second follow-up. No intervention effect was seen in relation to GP attitudes. Both before and after the intervention, the GPs were most informed about physical stressors, and less about mental and work organisational stressors (Guttman's reproducibility coefficient: 0.95 and 1.00. After

  17. Implementing structured functional assessments in general practice for persons with long-term sick leave: a cluster randomised controlled trial.

    Science.gov (United States)

    Østerås, Nina; Gulbrandsen, Pål; Benth, Jūrate Saltyte; Hofoss, Dag; Brage, Søren

    2009-05-06

    The increasing attention on functional assessments in medical and vocational rehabilitation requires a focus change for the general practitioners (GP) into paying attention to patient resources, possibilities and coping instead of symptoms, problems and limitations. The GPs report difficulties in performing the requested explicit functional assessments. The purpose of this study was to implement a structured method in general practice for assessing functional ability in persons with long-term sick leave. The study aim was to evaluate intervention effects on important GP parameters; knowledge, attitudes, self-efficacy towards functional assessments and knowledge about patient work factors. Fifty-seven GPs were randomly assigned to an intervention or a control group. The intervention group GPs attended an introductory one-day work-shop and implemented structured functional assessments during an eight months intervention period. GP knowledge, GP attitudes, and GP self-efficacy towards functional assessments, as well as GP knowledge of patient work factors, were collected before, after and six months after the intervention period started. Evaluation score-sheets were filled in by both the intervention GPs and their patients immediately after the consultation to evaluate the GPs' knowledge of patient work factors. The intervention GPs reported increased knowledge (B: 0.56, 95% CI (0.19, 0.91)) and self-efficacy (B: 0.90, 95% CI (0.53, 1.26)) towards functional assessments, and increased knowledge about their patients' workplace (B: 0.75, 95% CI (0.35, 1.15)) and perceived stressors (B: 0.55, 95% CI (0.23, 0.88)) with lasting effects at the second follow-up. No intervention effect was seen in relation to GP attitudes. Both before and after the intervention, the GPs were most informed about physical stressors, and less about mental and work organisational stressors (Guttman's reproducibility coefficient: 0.95 and 1.00). After the consultation, both the intervention GPs

  18. Web Accessibility and Guidelines

    Science.gov (United States)

    Harper, Simon; Yesilada, Yeliz

    Access to, and movement around, complex online environments, of which the World Wide Web (Web) is the most popular example, has long been considered an important and major issue in the Web design and usability field. The commonly used slang phrase ‘surfing the Web’ implies rapid and free access, pointing to its importance among designers and users alike. It has also been long established that this potentially complex and difficult access is further complicated, and becomes neither rapid nor free, if the user is disabled. There are millions of people who have disabilities that affect their use of the Web. Web accessibility aims to help these people to perceive, understand, navigate, and interact with, as well as contribute to, the Web, and thereby the society in general. This accessibility is, in part, facilitated by the Web Content Accessibility Guidelines (WCAG) currently moving from version one to two. These guidelines are intended to encourage designers to make sure their sites conform to specifications, and in that conformance enable the assistive technologies of disabled users to better interact with the page content. In this way, it was hoped that accessibility could be supported. While this is in part true, guidelines do not solve all problems and the new WCAG version two guidelines are surrounded by controversy and intrigue. This chapter aims to establish the published literature related to Web accessibility and Web accessibility guidelines, and discuss limitations of the current guidelines and future directions.

  19. OESbathy version 1.0: a method for reconstructing ocean bathymetry with generalized continental shelf-slope-rise structures

    Science.gov (United States)

    Goswami, A.; Olson, P. L.; Hinnov, L. A.; Gnanadesikan, A.

    2015-09-01

    We present a method for reconstructing global ocean bathymetry that combines a standard plate cooling model for the oceanic lithosphere based on the age of the oceanic crust, global oceanic sediment thicknesses, plus generalized shelf-slope-rise structures calibrated at modern active and passive continental margins. Our motivation is to develop a methodology for reconstructing ocean bathymetry in the geologic past that includes heterogeneous continental margins in addition to abyssal ocean floor. First, the plate cooling model is applied to maps of ocean crustal age to calculate depth to basement. To the depth to basement we add an isostatically adjusted, multicomponent sediment layer constrained by sediment thickness in the modern oceans and marginal seas. A three-parameter continental shelf-slope-rise structure completes the bathymetry reconstruction, extending from the ocean crust to the coastlines. Parameters of the shelf-slope-rise structures at active and passive margins are determined from modern ocean bathymetry at locations where a complete history of seafloor spreading is preserved. This includes the coastal regions of the North, South, and central Atlantic, the Southern Ocean between Australia and Antarctica, and the Pacific Ocean off the west coast of South America. The final products are global maps at 0.1° × 0.1° resolution of depth to basement, ocean bathymetry with an isostatically adjusted multicomponent sediment layer, and ocean bathymetry with reconstructed continental shelf-slope-rise structures. Our reconstructed bathymetry agrees with the measured ETOPO1 bathymetry at most passive margins, including the east coast of North America, north coast of the Arabian Sea, and northeast and southeast coasts of South America. There is disagreement at margins with anomalous continental shelf-slope-rise structures, such as around the Arctic Ocean, the Falkland Islands, and Indonesia.

  20. Assessing the Effects of ‘Stand-alone’ Structuration of Land Administration System on Urban Land Delivery and Accessibility in Nigeria

    Directory of Open Access Journals (Sweden)

    Akinbola Kazeem Bolayemi

    2016-12-01

    Full Text Available The efficiency and effectiveness of land administration system had been acknowledged to be premised on so many factors, arguably the chief of which, is the degree of mutuality, frictionlessness and bi-directionality in the interrelationship that exist amongst the various factors that are discharging arrays of tasks that these formal lands regulo-administrative machineries are saddled with. Undoubtedly, this simple conduct of affairs resultantly drives the formal lands delivery, hence it increases accessibility to urban lands by several categories of users in Nigeria, as thus the case globally. However, these interrelationships are absent among land administration and regulation systems in Nigeria. Hence, this study intends to assess the direct and possible indirect impacts that these interrelationships fallouts have on the formal delivery and accessibility of urban lands in Nigeria, Firstly, this was done by articulating the issues involved and calibrating them into constructs, then measuring them via the following score-cards, thus: myopism, non-ingenuity, disservice, eco-financial loss, distrust, trauma, anti-growth, death, market distortion and thriving informalisation focussing on the South Western Nigeria. Out of the total 586 individuals considered as the total population for the sample space, 120 individual qualified for the sample frame, upon which the structured questionnaires were distributed among land regulators, land administrators, independent land consultants and ultimate land users, essentially to have a fair and broad view of the issues inherent in this lands accessibility dilemma. 93 questionnaires were retrieved, out of which 87 questionnaires were valid, thus formed the basis upon which analyses were done, with emphasis on the 5 point Likert scale measurement usage, via both inferential and descriptive statistical tools. The results showed amongst other things, that unbridled relationship frictions had led to unwarranted role

  1. Welcome to Crystals: A New Open-Access, Multidisciplinary Forum for Growth, Structures and Properties of Crystals

    Directory of Open Access Journals (Sweden)

    Gerd Meyer

    2010-12-01

    Full Text Available The majority of the earth’s crust is made up of crystalline material. The research areas of mineralogy, petrology, chimie minerále (inorganic chemistry and, of course, crystallography outgrew from the fascination of mankind with the color and symmetry of crystals. Crystals have translational symmetry in two or three dimensions, quasicrystals have translational symmetry in higher spaces. Further symmetries may be observed by the eye, by microscopic techniques or by the diffraction of X-ray, electron, or neutron beams. Diffraction techniques are also used, due to Max von Laue’s eminent discovery a century ago, to determine crystal structures. [...

  2. New method to access hyperbranched polymers with uniform structure via one-pot polymerization of inimer in microemulsion.

    Science.gov (United States)

    Min, Ke; Gao, Haifeng

    2012-09-26

    A facile approach is presented for successful synthesis of hyperbranched polymers with high molecular weight and uniform structure by a one-pot polymerization of an inimer in a microemulsion. The segregated space in the microemulsion confined the inimer polymerization and particularly the polymer-polymer reaction within discrete nanoparticles. At the end of polymerization, each nanoparticle contained one hyperbranched polymer that had thousands of inimer units and low polydispersity. The hyperbranched polymers were used as multifunctional macroinitiators for synthesis of "hyper-star" polymers. When a degradable inimer was applied, the hyper-stars showed fast degradation into linear polymer chains with low molecular weight.

  3. Open Access

    Science.gov (United States)

    Suber, Peter

    2012-01-01

    The Internet lets us share perfect copies of our work with a worldwide audience at virtually no cost. We take advantage of this revolutionary opportunity when we make our work "open access": digital, online, free of charge, and free of most copyright and licensing restrictions. Open access is made possible by the Internet and copyright-holder…

  4. Open access

    African Journals Online (AJOL)

    Prof. Dennis Ocholla

    The argument that access to information is an instrumental and individual as well as ... and Dean School of Information Studies, University of Wisconsin, Milwaukee, USA. ... to scholarly publications and can be in any digital format, including text, movies and ... language barriers, censorship, lack of access to the Internet and ...

  5. Modulating chromatin structure and DNA accessibility by deacetylase inhibition enhances the anti-cancer activity of silver nanoparticles.

    Science.gov (United States)

    Igaz, Nóra; Kovács, Dávid; Rázga, Zsolt; Kónya, Zoltán; Boros, Imre M; Kiricsi, Mónika

    2016-10-01

    Histone deacetylase (HDAC) inhibitors are considered as novel therapeutic agents inducing cell cycle arrest and apoptotic cell death in various cancer cells. Inhibition of deacetylase activity results in a relaxed chromatin structure thereby rendering the genetic material more vulnerable to DNA targeting agents that could be exploited by combinational cancer therapy. The unique potential of silver nanoparticles (AgNPs) in tumor therapy relies on the generation of reactive radicals which trigger oxidative stress, DNA damage and apoptosis in cancer cells. The revolutionary application of AgNPs as chemotherapeutical drugs seems very promising, nevertheless the exact molecular mechanisms of AgNP action in combination with other anti-cancer agents have yet to be elucidated in details before clinical administrations. As a step towards this we investigated the combinational effect of HDAC inhibition and AgNP administration in HeLa cervical cancer cells. We identified synergistic inhibition of cancer cell growth and migration upon combinational treatments. Here we report that the HDAC inhibitor Trichostatin A enhances the DNA targeting capacity and apoptosis inducing efficacy of AgNPs most probably due to its effect on chromatin condensation. These results point to the potential benefits of combinational application of HDAC inhibitors and AgNPs in novel cancer medication protocols. Copyright © 2016 Elsevier B.V. All rights reserved.

  6. Preemption versus Entrenchment: Towards a Construction-General Solution to the Problem of the Retreat from Verb Argument Structure Overgeneralization.

    Directory of Open Access Journals (Sweden)

    Ben Ambridge

    Full Text Available Participants aged 5;2-6;8, 9;2-10;6 and 18;1-22;2 (72 at each age rated verb argument structure overgeneralization errors (e.g., *Daddy giggled the baby using a five-point scale. The study was designed to investigate the feasibility of two proposed construction-general solutions to the question of how children retreat from, or avoid, such errors. No support was found for the prediction of the preemption hypothesis that the greater the frequency of the verb in the single most nearly synonymous construction (for this example, the periphrastic causative; e.g., Daddy made the baby giggle, the lower the acceptability of the error. Support was found, however, for the prediction of the entrenchment hypothesis that the greater the overall frequency of the verb, regardless of construction, the lower the acceptability of the error, at least for the two older groups. Thus while entrenchment appears to be a robust solution to the problem of the retreat from error, and one that generalizes across different error types, we did not find evidence that this is the case for preemption. The implication is that the solution to the retreat from error lies not with specialized mechanisms, but rather in a probabilistic process of construction competition.

  7. Structured functional assessments in general practice increased the use of part-time sick leave: a cluster randomised controlled trial.

    Science.gov (United States)

    Osterås, Nina; Gulbrandsen, Pål; Kann, Inger Cathrine; Brage, Søren

    2010-03-01

    A method for structured functional assessments of persons with long-term sick leave was implemented in a cluster randomised controlled trial in general practice. The aim was to analyse intervention effects on general practitioner (GP) sick-listing practice and patient sick leave. 57 GPs were randomly assigned to an intervention or a control group. The intervention group GPs learned the method at a 1-day workshop including teamwork and role-playing. The control group GPs were requested to assess functional ability as usual during the 8 months intervention period in 2005. Outcome measures included duration of patient sick leave episodes, GP prescription of part-time sick leave, active sick leave, and vocational rehabilitation. This data was extracted from a national register. The GPs in the intervention group prescribed part-time sick leave more often (p part-time and less active sick leave compared to the control group GPs. As a result, more intervention GP patients returned to part-time work compared to control GP patients. No intervention effect was seen on duration of patient sick leave episodes or on prescription of vocational rehabilitation.

  8. Structure of the first order reduced density matrix in three electron systems: A generalized Pauli constraints assisted study.

    Science.gov (United States)

    Theophilou, Iris; Lathiotakis, Nektarios N; Helbig, Nicole

    2018-03-21

    We investigate the structure of the one-body reduced density matrix of three electron systems, i.e., doublet and quadruplet spin configurations, corresponding to the smallest interacting system with an open-shell ground state. To this end, we use configuration interaction (CI) expansions of the exact wave function in Slater determinants built from natural orbitals in a finite dimensional Hilbert space. With the exception of maximally polarized systems, the natural orbitals of spin eigenstates are generally spin dependent, i.e., the spatial parts of the up and down natural orbitals form two different sets. A measure to quantify this spin dependence is introduced and it is shown that it varies by several orders of magnitude depending on the system. We also study the ordering issue of the spin-dependent occupation numbers which has practical implications in reduced density matrix functional theory minimization schemes, when generalized Pauli constraints (GPCs) are imposed and in the form of the CI expansion in terms of the natural orbitals. Finally, we discuss the aforementioned CI expansion when there are GPCs that are almost "pinned."

  9. Structure of the first order reduced density matrix in three electron systems: A generalized Pauli constraints assisted study

    Science.gov (United States)

    Theophilou, Iris; Lathiotakis, Nektarios N.; Helbig, Nicole

    2018-03-01

    We investigate the structure of the one-body reduced density matrix of three electron systems, i.e., doublet and quadruplet spin configurations, corresponding to the smallest interacting system with an open-shell ground state. To this end, we use configuration interaction (CI) expansions of the exact wave function in Slater determinants built from natural orbitals in a finite dimensional Hilbert space. With the exception of maximally polarized systems, the natural orbitals of spin eigenstates are generally spin dependent, i.e., the spatial parts of the up and down natural orbitals form two different sets. A measure to quantify this spin dependence is introduced and it is shown that it varies by several orders of magnitude depending on the system. We also study the ordering issue of the spin-dependent occupation numbers which has practical implications in reduced density matrix functional theory minimization schemes, when generalized Pauli constraints (GPCs) are imposed and in the form of the CI expansion in terms of the natural orbitals. Finally, we discuss the aforementioned CI expansion when there are GPCs that are almost "pinned."

  10. General mixture item response models with different item response structures: Exposition with an application to Likert scales.

    Science.gov (United States)

    Tijmstra, Jesper; Bolsinova, Maria; Jeon, Minjeong

    2018-01-10

    This article proposes a general mixture item response theory (IRT) framework that allows for classes of persons to differ with respect to the type of processes underlying the item responses. Through the use of mixture models, nonnested IRT models with different structures can be estimated for different classes, and class membership can be estimated for each person in the sample. If researchers are able to provide competing measurement models, this mixture IRT framework may help them deal with some violations of measurement invariance. To illustrate this approach, we consider a two-class mixture model, where a person's responses to Likert-scale items containing a neutral middle category are either modeled using a generalized partial credit model, or through an IRTree model. In the first model, the middle category ("neither agree nor disagree") is taken to be qualitatively similar to the other categories, and is taken to provide information about the person's endorsement. In the second model, the middle category is taken to be qualitatively different and to reflect a nonresponse choice, which is modeled using an additional latent variable that captures a person's willingness to respond. The mixture model is studied using simulation studies and is applied to an empirical example.

  11. Structuring energy supply and demand networks in a general equilibrium model to simulate global warming control strategies

    International Nuclear Information System (INIS)

    Hamilton, S.; Veselka, T.D.; Cirillo, R.R.

    1991-01-01

    Global warming control strategies which mandate stringent caps on emissions of greenhouse forcing gases can substantially alter a country's demand, production, and imports of energy products. Although there is a large degree of uncertainty when attempting to estimate the potential impact of these strategies, insights into the problem can be acquired through computer model simulations. This paper presents one method of structuring a general equilibrium model, the ENergy and Power Evaluation Program/Global Climate Change (ENPEP/GCC), to simulate changes in a country's energy supply and demand balance in response to global warming control strategies. The equilibrium model presented in this study is based on the principle of decomposition, whereby a large complex problem is divided into a number of smaller submodules. Submodules simulate energy activities and conversion processes such as electricity production. These submodules are linked together to form an energy supply and demand network. Linkages identify energy and fuel flows among various activities. Since global warming control strategies can have wide reaching effects, a complex network was constructed. The network represents all energy production, conversion, transportation, distribution, and utilization activities. The structure of the network depicts interdependencies within and across economic sectors and was constructed such that energy prices and demand responses can be simulated. Global warming control alternatives represented in the network include: (1) conservation measures through increased efficiency; and (2) substitution of fuels that have high greenhouse gas emission rates with fuels that have lower emission rates. 6 refs., 4 figs., 4 tabs

  12. Gender differences in the structural connectome of the teenage brain revealed by generalized q-sampling MRI

    Directory of Open Access Journals (Sweden)

    Yeu-Sheng Tyan

    2017-01-01

    Full Text Available The question of whether there are biological differences between male and female brains is a fraught one, and political positions and prior expectations seem to have a strong influence on the interpretation of scientific data in this field. This question is relevant to issues of gender differences in the prevalence of psychiatric conditions, including autism, attention deficit hyperactivity disorder (ADHD, Tourette's syndrome, schizophrenia, dyslexia, depression, and eating disorders. Understanding how gender influences vulnerability to these conditions is significant. Diffusion magnetic resonance imaging (dMRI provides a non-invasive method to investigate brain microstructure and the integrity of anatomical connectivity. Generalized q-sampling imaging (GQI has been proposed to characterize complicated fiber patterns and distinguish fiber orientations, providing an opportunity for more accurate, higher-order descriptions through the water diffusion process. Therefore, we aimed to investigate differences in the brain's structural network between teenage males and females using GQI. This study included 59 (i.e., 33 males and 26 females age- and education-matched subjects (age range: 13 to 14 years. The structural connectome was obtained by graph theoretical and network-based statistical (NBS analyses. Our findings show that teenage male brains exhibit better intrahemispheric communication, and teenage female brains exhibit better interhemispheric communication. Our results also suggest that the network organization of teenage male brains is more local, more segregated, and more similar to small-world networks than teenage female brains. We conclude that the use of an MRI study with a GQI-based structural connectomic approach like ours presents novel insights into network-based systems of the brain and provides a new piece of the puzzle regarding gender differences.

  13. Gender differences in the structural connectome of the teenage brain revealed by generalized q-sampling MRI.

    Science.gov (United States)

    Tyan, Yeu-Sheng; Liao, Jan-Ray; Shen, Chao-Yu; Lin, Yu-Chieh; Weng, Jun-Cheng

    2017-01-01

    The question of whether there are biological differences between male and female brains is a fraught one, and political positions and prior expectations seem to have a strong influence on the interpretation of scientific data in this field. This question is relevant to issues of gender differences in the prevalence of psychiatric conditions, including autism, attention deficit hyperactivity disorder (ADHD), Tourette's syndrome, schizophrenia, dyslexia, depression, and eating disorders. Understanding how gender influences vulnerability to these conditions is significant. Diffusion magnetic resonance imaging (dMRI) provides a non-invasive method to investigate brain microstructure and the integrity of anatomical connectivity. Generalized q-sampling imaging (GQI) has been proposed to characterize complicated fiber patterns and distinguish fiber orientations, providing an opportunity for more accurate, higher-order descriptions through the water diffusion process. Therefore, we aimed to investigate differences in the brain's structural network between teenage males and females using GQI. This study included 59 (i.e., 33 males and 26 females) age- and education-matched subjects (age range: 13 to 14 years). The structural connectome was obtained by graph theoretical and network-based statistical (NBS) analyses. Our findings show that teenage male brains exhibit better intrahemispheric communication, and teenage female brains exhibit better interhemispheric communication. Our results also suggest that the network organization of teenage male brains is more local, more segregated, and more similar to small-world networks than teenage female brains. We conclude that the use of an MRI study with a GQI-based structural connectomic approach like ours presents novel insights into network-based systems of the brain and provides a new piece of the puzzle regarding gender differences.

  14. Access Contested

    International Development Research Centre (IDRC) Digital Library (Canada)

    Transforming Global Information and Communication Markets: The Political Economy of ... 8 Control and Resistance: Attacks on Burmese Opposition Media 153 ...... “Reluctant Gatekeepers: Corporate Ethics on a Filtered Internet,” in Access ...

  15. Accessing memory

    Science.gov (United States)

    Yoon, Doe Hyun; Muralimanohar, Naveen; Chang, Jichuan; Ranganthan, Parthasarathy

    2017-09-26

    A disclosed example method involves performing simultaneous data accesses on at least first and second independently selectable logical sub-ranks to access first data via a wide internal data bus in a memory device. The memory device includes a translation buffer chip, memory chips in independently selectable logical sub-ranks, a narrow external data bus to connect the translation buffer chip to a memory controller, and the wide internal data bus between the translation buffer chip and the memory chips. A data access is performed on only the first independently selectable logical sub-rank to access second data via the wide internal data bus. The example method also involves locating a first portion of the first data, a second portion of the first data, and the second data on the narrow external data bus during separate data transfers.

  16. Forbidden Access

    CERN Multimedia

    C. Colloca TS/FM

    2004-01-01

    TS/FM group informs you that, for the replacement of the door of the main entrance at bldg. 500, the access will be closed to the public between 19 and 30 July 2004. Access to the Main Building complex will be assured at any time through both of the side doors and from bldg. 64. For more information, please contact 73273. C. Colloca TS/FM

  17. The effects of structure anisotropy on lensing observables in an exact general relativistic setting for precision cosmology

    Energy Technology Data Exchange (ETDEWEB)

    Troxel, M. A.; Ishak, Mustapha; Peel, Austin, E-mail: troxel@utdallas.edu, E-mail: mishak@utdallas.edu, E-mail: austin.peel@utdallas.edu [Department of Physics, The University of Texas at Dallas, Richardson, TX 75080 (United States)

    2014-03-01

    The study of relativistic, higher order, and nonlinear effects has become necessary in recent years in the pursuit of precision cosmology. We develop and apply here a framework to study gravitational lensing in exact models in general relativity that are not restricted to homogeneity and isotropy, and where full nonlinearity and relativistic effects are thus naturally included. We apply the framework to a specific, anisotropic galaxy cluster model which is based on a modified NFW halo density profile and described by the Szekeres metric. We examine the effects of increasing levels of anisotropy in the galaxy cluster on lensing observables like the convergence and shear for various lensing geometries, finding a strong nonlinear response in both the convergence and shear for rays passing through anisotropic regions of the cluster. Deviation from the expected values in a spherically symmetric structure are asymmetric with respect to path direction and thus will persist as a statistical effect when averaged over some ensemble of such clusters. The resulting relative difference in various geometries can be as large as approximately 2%, 8%, and 24% in the measure of convergence (1−κ) for levels of anisotropy of 5%, 10%, and 15%, respectively, as a fraction of total cluster mass. For the total magnitude of shear, the relative difference can grow near the center of the structure to be as large as 15%, 32%, and 44% for the same levels of anisotropy, averaged over the two extreme geometries. The convergence is impacted most strongly for rays which pass in directions along the axis of maximum dipole anisotropy in the structure, while the shear is most strongly impacted for rays which pass in directions orthogonal to this axis, as expected. The rich features found in the lensing signal due to anisotropic substructure are nearly entirely lost when one treats the cluster in the traditional FLRW lensing framework. These effects due to anisotropic structures are thus likely to

  18. Access to the city

    DEFF Research Database (Denmark)

    Andreasen, Manja Hoppe; Møller-Jensen, Lasse

    2017-01-01

    This paper is concerned with access to the city for urban residents living in the periphery of Dar es Salaam, Tanzania. The paper presents an analysis of the mobility practices of residents and investigates the mobility constraints they experience in relation to the limited accessibility provided...... mobility and access to the city for residents in the periphery. Regular mobility is an ingrained part of residents' livelihood strategies. The majority of households rely on one or more members regularly travelling to central parts of the city in relation to their livelihood activities. The analysis...... by road and traffic conditions and highlights how accessibility problems of peripheral settlements are not easily understood separately from the general dysfunctions of the overall mobility system of city....

  19. Access road reclamation

    International Nuclear Information System (INIS)

    Manson, T.; Blok, M.

    1997-01-01

    A general review of the measures involved in restoring abandoned access road sites in British Columbia was presented. Permits and licences are needed for the use of crown land for roads used by the petroleum and natural gas industry for exploration activities. However, the regulatory framework for road site reclamation is not well developed. The nature of access road reclamation is very site-specific. Some of the issues that are considered for all reclamation projects include slope stability, water control, revegetation, soil rehabilitation, access management and monitoring. The primary objective of reclaiming access road sites is to return the site to conditions that are equal or better than pre-disturbance conditions. Restoration measures must be approved by BC Environment and by the Department of Fisheries and Oceans where federal fisheries responsibilities are involved. 54 refs., 5 tabs., 3 figs

  20. Pediatric vascular access

    International Nuclear Information System (INIS)

    Donaldson, James S.

    2006-01-01

    Pediatric interventional radiologists are ideally suited to provide vascular access services to children because of inherent safety advantages and higher success from using image-guided techniques. The performance of vascular access procedures has become routine at many adult interventional radiology practices, but this service is not as widely developed at pediatric institutions. Although interventional radiologists at some children's hospitals offer full-service vascular access, there is little or none at others. Developing and maintaining a pediatric vascular access service is a challenge. Interventionalists skilled in performing such procedures are limited at pediatric institutions, and institutional support from clerical staff, nursing staff, and technologists might not be sufficiently available to fulfill the needs of such a service. There must also be a strong commitment by all members of the team to support such a demanding service. There is a slippery slope of expected services that becomes steeper and steeper as the vascular access service grows. This review is intended primarily as general education for pediatric radiologists learning vascular access techniques. Additionally, the pediatric or adult interventional radiologist seeking to expand services might find helpful tips. The article also provides education for the diagnostic radiologist who routinely interprets radiographs containing vascular access devices. (orig.)

  1. Accessible Knowledge - Knowledge on Accessibility

    DEFF Research Database (Denmark)

    Kirkeby, Inge Mette

    2015-01-01

    Although serious efforts are made internationally and nationally, it is a slow process to make our physical environment accessible. In the actual design process, architects play a major role. But what kinds of knowledge, including research-based knowledge, do practicing architects make use of when...... designing accessible environments? The answer to the question is crucially important since it affects how knowledge is distributed and how accessibility can be ensured. In order to get first-hand knowledge about the design process and the sources from which they gain knowledge, 11 qualitative interviews...... were conducted with architects with experience of designing for accessibility. The analysis draws on two theoretical distinctions. The first is research-based knowledge versus knowledge used by architects. The second is context-independent knowledge versus context-dependent knowledge. The practitioners...

  2. Generalized green synthesis and formation mechanism of sponge-like ferrite micro-polyhedra with tunable structure and composition

    Science.gov (United States)

    Tong, Guoxiu; Du, Fangfang; Xiang, Lingjing; Liu, Fangting; Mao, Lulu; Guan, Jianguo

    2013-12-01

    This paper describes a green versatile glucose-engineered precipitation-sintering process that allows for the selective and mass preparation of spongy porous ferrite (M = Fe, Zn, Co, Ni, Mn, etc.) micro-polyhedra with tunable morphology, texture, and composition. Some kinetic factors, such as the molar ratio of glucose to metal nitrates, reaction temperature, sintering temperature and time, and type of metal nitrates, can be expediently employed to modulate their aspect ratio, shape, size, composition, and textural properties. In this protocol, glucose functions as a reductant, protecting agent, structure-directing agent, and a sacrificial template to guide the assembly of sheet-like nuclei into polyhedral precursors and the formation of spongy porous structures. Owing to larger EM parameters, multiresonant behavior, and dissipative current, spongy porous Fe3O4 polyhedra exhibited enhanced microwave-absorbing properties. This endows them with important potential applications in magnetic devices, catalysis, sorption, photoluminescence, electromagnetic wave absorbing materials, anode materials, and so on. Meanwhile, this general approach can be extended to synthesize other porous sponges with regular geometric configuration because it is simple, inexpensive, environmentally benign, and suitable for extensive production.This paper describes a green versatile glucose-engineered precipitation-sintering process that allows for the selective and mass preparation of spongy porous ferrite (M = Fe, Zn, Co, Ni, Mn, etc.) micro-polyhedra with tunable morphology, texture, and composition. Some kinetic factors, such as the molar ratio of glucose to metal nitrates, reaction temperature, sintering temperature and time, and type of metal nitrates, can be expediently employed to modulate their aspect ratio, shape, size, composition, and textural properties. In this protocol, glucose functions as a reductant, protecting agent, structure-directing agent, and a sacrificial template to

  3. Equity of access to elective surgery: reflections from NZ clinicians.

    Science.gov (United States)

    McLeod, Deborah; Dew, Kevin; Morgan, Sonya; Dowell, Anthony; Cumming, Jackie; Cormack, Donna; McKinlay, Eileen; Love, Tom

    2004-10-01

    To explore factors potentially influencing equitable access to elective surgery in New Zealand by describing clinicians' perceptions of equity and the factors they consider when prioritising patients for elective surgery. A qualitative study in selected New Zealand localities. A purposive sample of 49 general practitioners, specialists and registrars were interviewed. Data were analysed thematically. General practitioners described unequal opportunities for patients to access primary and secondary care and, in particular, private sector elective surgery. They felt that socio-economically disadvantaged patients were less able to advocate for themselves and were more vulnerable to being lost to the elective surgical booking system as well as being less able to access private care. Both GPs and secondary care clinicians described situations where they would personally advocate for individual patients to improve their access. Advocacy was related to clinicians' perceptions of the 'value' that patients would receive from the surgery and patients' needs for public sector funding. The structure of the health system contributes to inequities in access to elective care in New Zealand. Subjective decision making by clinicians has the potential to advantage or disadvantage patients through the weighting clinicians place on socio-demographic factors when making rationing decisions. Review of the potential structural barriers to equitable access, further public debate and guidance for clinicians on the relative importance of socio-demographic factors in deciding access to rationed services are required for allocation of services to be fair.

  4. Open access

    CERN Document Server

    Suber, Peter

    2012-01-01

    The Internet lets us share perfect copies of our work with a worldwide audience at virtually no cost. We take advantage of this revolutionary opportunity when we make our work "open access": digital, online, free of charge, and free of most copyright and licensing restrictions. Open access is made possible by the Internet and copyright-holder consent, and many authors, musicians, filmmakers, and other creators who depend on royalties are understandably unwilling to give their consent. But for 350 years, scholars have written peer-reviewed journal articles for impact, not for money, and are free to consent to open access without losing revenue. In this concise introduction, Peter Suber tells us what open access is and isn't, how it benefits authors and readers of research, how we pay for it, how it avoids copyright problems, how it has moved from the periphery to the mainstream, and what its future may hold. Distilling a decade of Suber's influential writing and thinking about open access, this is the indispe...

  5. Market Structure and Market Access

    OpenAIRE

    Joseph Francois; Ian Wooton

    2008-01-01

    The authors examine an issue at the nexus of domestic competition policy and international trade, the interaction between goods trade and market power in domestic trade and distribution sectors. Theory suggests a set of linkages between service-sector competition and goods trade supported by econometrics involving imports of 22 OECD countries compared with 69 exporters. Competition in serv...

  6. The General Aggression Model.

    Science.gov (United States)

    Allen, Johnie J; Anderson, Craig A; Bushman, Brad J

    2018-02-01

    The General Aggression Model (GAM) is a comprehensive, integrative, framework for understanding aggression. It considers the role of social, cognitive, personality, developmental, and biological factors on aggression. Proximate processes of GAM detail how person and situation factors influence cognitions, feelings, and arousal, which in turn affect appraisal and decision processes, which in turn influence aggressive or nonaggressive behavioral outcomes. Each cycle of the proximate processes serves as a learning trial that affects the development and accessibility of aggressive knowledge structures. Distal processes of GAM detail how biological and persistent environmental factors can influence personality through changes in knowledge structures. GAM has been applied to understand aggression in many contexts including media violence effects, domestic violence, intergroup violence, temperature effects, pain effects, and the effects of global climate change. Copyright © 2017 Elsevier Ltd. All rights reserved.

  7. General conditions applicable to the contract for access to the public power transportation network for an eligible consuming site; Conditions generales applicables au contrat d'acces au reseau public de transport d'electricite pour un site consommateur eligible

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2002-11-01

    On 1 November 2002, the new tariffs for the utilisation of the public power transmission and distribution networks, defined by decree no 2002-1014 of 19 July 2002, will come into effect. A new contract for access to the transmission network has been drawn up in co-operation with the Energy Regulation Commission (CRE) so as to be able to include these new tariffs. This new contract also takes into account the expectations expressed by the users of the transmission network concerning the energy delivery agreement used since the coming into effect of the European Directive on the opening of the electricity market in February 1999. On 31 October 2002, RTE is publishing a new version of the contract for access to the Public Transmission Networks. This document reproduces the general conditions of this contract. It comprises the following parts: preamble; definitions; connection to the public transportation network; metering and deductions; subscribed power; development, exploitation and maintenance of facilities; power continuity and quality; liability; tariffing and conditions of payment; declaration of the balancing actor; general dispositions.

  8. Gaining Access.

    Science.gov (United States)

    Wand, Sean; Thermos, Adam C.

    1998-01-01

    Explains the issues to consider before a college decides to purchase a card-access system. The benefits of automation, questions involving implementation, the criteria for technology selection, what typical card technology involves, privacy concerns, and the placement of card readers are discussed. (GR)

  9. General dental practitioner's views on dental general anaesthesia services.

    Science.gov (United States)

    Threlfall, A G; King, D; Milsom, K M; Blinkhom, A S; Tickle, M

    2007-06-01

    Policy has recently changed on provision of dental general anaesthetic services in England. The aim of this study was to investigate general dental practitioners' views about dental general anaesthetics, the reduction in its availability and the impact on care of children with toothache. Qualitative study using semi-structured interviews and clinical case scenarios. General dental practitioners providing NHS services in the North West of England. 93 general dental practitioners were interviewed and 91 answered a clinical case scenario about the care they would provide for a 7-year-old child with multiple decayed teeth presenting with toothache. Scenario responses showed variation; 8% would immediately refer for general anaesthesia, 25% would initially prescribe antibiotics, but the majority would attempt to either restore or extract the tooth causing pain. Interview responses also demonstrated variation in care, however most dentists agree general anaesthesia has a role for nervous children but only refer as a last resort. The responses indicated an increase in inequalities, and that access to services did not match population needs, leaving some children waiting in pain. Most general dental practitioners support moving dental general anaesthesia into hospitals but some believe that it has widened health inequalities and there is also a problem associated with variation in treatment provision. Additional general anaesthetic services in some areas with high levels of tooth decay are needed and evidence based guidelines about caring for children with toothache are required.

  10. Quantum random access memory

    OpenAIRE

    Giovannetti, Vittorio; Lloyd, Seth; Maccone, Lorenzo

    2007-01-01

    A random access memory (RAM) uses n bits to randomly address N=2^n distinct memory cells. A quantum random access memory (qRAM) uses n qubits to address any quantum superposition of N memory cells. We present an architecture that exponentially reduces the requirements for a memory call: O(log N) switches need be thrown instead of the N used in conventional (classical or quantum) RAM designs. This yields a more robust qRAM algorithm, as it in general requires entanglement among exponentially l...

  11. Brain maps 4.0-Structure of the rat brain: An open access atlas with global nervous system nomenclature ontology and flatmaps.

    Science.gov (United States)

    Swanson, Larry W

    2018-04-15

    The fourth edition (following editions in 1992, 1998, 2004) of Brain maps: structure of the rat brain is presented here as an open access internet resource for the neuroscience community. One new feature is a set of 10 hierarchical nomenclature tables that define and describe all parts of the rat nervous system within the framework of a strictly topographic system devised previously for the human nervous system. These tables constitute a global ontology for knowledge management systems dealing with neural circuitry. A second new feature is an aligned atlas of bilateral flatmaps illustrating rat nervous system development from the neural plate stage to the adult stage, where most gray matter regions, white matter tracts, ganglia, and nerves listed in the nomenclature tables are illustrated schematically. These flatmaps are convenient for future development of online applications analogous to "Google Maps" for systems neuroscience. The third new feature is a completely revised Atlas of the rat brain in spatially aligned transverse sections that can serve as a framework for 3-D modeling. Atlas parcellation is little changed from the preceding edition, but the nomenclature for rat is now aligned with an emerging panmammalian neuroanatomical nomenclature. All figures are presented in Adobe Illustrator vector graphics format that can be manipulated, modified, and resized as desired, and freely used with a Creative Commons license. © 2018 The Authors The Journal of Comparative Neurology Published by Wiley Periodicals, Inc.

  12. Brain maps 4.0—Structure of the rat brain: An open access atlas with global nervous system nomenclature ontology and flatmaps

    Science.gov (United States)

    2018-01-01

    Abstract The fourth edition (following editions in 1992, 1998, 2004) of Brain maps: structure of the rat brain is presented here as an open access internet resource for the neuroscience community. One new feature is a set of 10 hierarchical nomenclature tables that define and describe all parts of the rat nervous system within the framework of a strictly topographic system devised previously for the human nervous system. These tables constitute a global ontology for knowledge management systems dealing with neural circuitry. A second new feature is an aligned atlas of bilateral flatmaps illustrating rat nervous system development from the neural plate stage to the adult stage, where most gray matter regions, white matter tracts, ganglia, and nerves listed in the nomenclature tables are illustrated schematically. These flatmaps are convenient for future development of online applications analogous to “Google Maps” for systems neuroscience. The third new feature is a completely revised Atlas of the rat brain in spatially aligned transverse sections that can serve as a framework for 3‐D modeling. Atlas parcellation is little changed from the preceding edition, but the nomenclature for rat is now aligned with an emerging panmammalian neuroanatomical nomenclature. All figures are presented in Adobe Illustrator vector graphics format that can be manipulated, modified, and resized as desired, and freely used with a Creative Commons license. PMID:29277900

  13. A New, General Strategy for Fabricating Highly Concentrated and Viscoplastic Suspensions Based on a Structural Approach To Modulate Interparticle Interaction.

    Science.gov (United States)

    Sakurai, Shunsuke; Kamada, Fuminori; Kobashi, Kazufumi; Futaba, Don N; Hata, Kenji

    2018-01-24

    We report a general strategy to fabricate highly concentrated, viscoplastic and stable suspensions by designing the particle surface structure to control the interparticle attractive forces. Unlike conventional methods, where the choice of solvent is critical in balancing interparticle interactions, suspensions showing excellent stability and viscoplastic properties were made using various solvents. We demonstrated this approach using highly sparse agglomerates of carbon nanotubes (CNTs) as the particles. Our results revealed that the essential feature of the CNT agglomerate to fabricate these suspensions was high porosity with a spacing size much smaller than the overall size, which was only possible using long single-walled carbon nanotubes (SWNTs). In this way, the agglomerate surface was characterized by fine network of CNT bundles. These suspensions exhibited solid-like behavior at rest (characterized by a high yield stress of c.a. 100 Pa) and a liquid-like behavior when subjected to a stress (characterized by a significant drop of an apparent viscosity to 1 Pa·s at a shear rate of 1000 s -1 ). Furthermore, in contrast to conventionally fabricated suspensions, these "CNT pastes" exhibited exceptional stability at rest, under flow, and at extremely high concentrations during the drying process, with only a weakly observable dependence on solvent type. As a result, highly uniform micrometer-thick SWNT films were successfully fabricated by dried blade-coated films of these pastes. Finally, we developed a simple, semiempirical model and clarified the importance of the CNT agglomerate microstructure (the ratio of spacing size/particle size and porosity) on tailoring the cohesive forces between particles to fabricate stable viscoplastic suspensions.

  14. Free Access Does Not Necessarily Encourage Practitioners to Use Online Evidence Based Information Tools. A Review of: Buchan, H., Lourey, E., D’Este, C., & Sanson-Fisher, R. (2009. Effectiveness of strategies to encourage general practitioners to accept an offer of free access to online evidence-based information: A randomised controlled trial. Implementation Science, 4, article 68.

    Directory of Open Access Journals (Sweden)

    Heather Ganshorn

    2010-12-01

    Full Text Available Objectives – To determine which strategies were most effective for encouraging general practitioners (GPs to sign up for free access to an online evidence based information resource; and to determine whether those who accepted the offer differed in their sociodemographic characteristics from those who did not.Design – Descriptive marketing research study.Setting – Australia’s public healthcare system.Subjects – 14,000 general practitioners (GPs from all regions of Australia.Methods – Subjects were randomly selected by Medicare Australia from its list of GPs that bill it for services. Medicare Australia had 18,262 doctors it deemed eligible; 14,000 of these were selected for a stratified random sample. Subjects were randomized to one of 7 groups of 2,000 each. Each group received a different letter offering two years of free access to BMJ Clinical Evidence, an evidence based online information tool. Randomization was done electronically, and the seven groups were stratified by age group, gender, and location. The interventions given to each group differed as follows:• Group 1: Received a letter offering 2 years of free access, with no further demands on the recipient.• Group 2: Received a letter offering 2 years of free access, but on the condition that they complete an initial questionnaire and another one at 12 months, as well as allowing the publisher to provide de-personalized usage data to the researchers.• Group 3: Same as Group 2, but with the additional offer of an online tutorial to assist them with using the resource.• Group 4: Same as Group 2, but with an additional pamphlet with positive testimonials about the resource from Australian medical opinion leaders.• Group 5: Same as Group 2, but with an additional offer of professional development credits towards their required annual totals.• Group 6: Same as Group 2, but with an additional offer to be entered to win a prize of $500 towards registration at a

  15. Access control system operation

    International Nuclear Information System (INIS)

    Barnes, L.D.

    1981-06-01

    An automated method for the control and monitoring of personnel movement throughout the site was developed under contract to the Department of Energy by Allied-General Nuclear Services (AGNS) at the Barnwell Nuclear Fuel Plant (BNFP). These automated features provide strict enforcement of personnel access policy without routine patrol officer involvement. Identification methods include identification by employee ID number, identification by voice verification and identification by physical security officer verification. The ability to grant each level of access authority is distributed over the organization to prevent any single individual at any level in the organization from being capable of issuing an authorization for entry into sensitive areas. Each access event is recorded. As access events occur, the inventory of both the entered and the exited control area is updated so that a current inventory is always available for display. The system has been operated since 1979 in a development mode and many revisions have been implemented in hardware and software as areas were added to the system. Recent changes have involved the installation of backup systems and other features required to achieve a high reliability. The access control system and recent operating experience are described

  16. Factor structure of the General Health Questionnaire-28 (GHQ-28 from infertile women attending the Yazd Research and Clinical Center for Infertility

    Directory of Open Access Journals (Sweden)

    Zahra Shayan

    2015-12-01

    Full Text Available Background: Nowadays, infertility problems have become a social concern, and are associated with multiple psychological and social problems. Also, it affects the interpersonal communication between the individual, familial, and social characteristics. Since women are exposed to stressors of physical, mental, social factors, and treatment of infertility, providing a psychometric screening tool is necessary for disorders of this group. Objective: The aim of this study was to determine the factor structure of the general health questionnaire-28 to discover mental disorders in infertile women. Materials and Methods: In this study, 220 infertile women undergoing treatment of infertility were selected from the Yazd Research and Clinical Center for Infertility with convenience sampling in 2011. After completing the general health questionnaire by the project manager, validity and, reliability of the questionnaire were calculated by confirmatory factor structure and Cronbach's alpha, respectively. Results: Four factors, including anxiety and insomnia, social dysfunction, depression, and physical symptoms were extracted from the factor structure. 50.12% of the total variance was explained by four factors. The reliability coefficient of the questionnaire was obtained 0.90. Conclusion: Analysis of the factor structure and reliability of General Health Questionnaire-28 showed that it is suitable as a screening instrument for assessing general health of infertile women.

  17. Exploring the expectations, needs and experiences of general practitioners and nurses towards a proactive and structured care program for frail older patients: a mixed-method study

    NARCIS (Netherlands)

    Valerie ten Dam; Mattijs Numans; Nienke Bleijenberg; Bas Steunenberg; Niek de Wit; Prof. Dr. Marieke J. Schuurmans; Irene Drubbel

    2013-01-01

    Aim. To report the expectations and experiences of general practitioners and practice nurses regarding the U-CARE programme, to gain a better understanding of the barriers and facilitators in providing proactive, structured care to frail older people and to determine whether implementation is

  18. A cross-cultural study of the structure of comorbidity among common psychopathological syndromes in the general health care setting

    NARCIS (Netherlands)

    Krueger, RF; Chentsova-Dutton, YE; Markon, KE; Goldberg, D; Ormel, J

    This study presents analyses of 7 common psychopathological syndromes in the World Health Organization (WHO) Collaborative Study of Psychological Problems in General Health Care (T. B. Ustun & N. Sartorius, 1995). Data on depression, somatization, hypochondriasis, neurasthenia, anxious worry,

  19. Accessing remote data bases using microcomputers

    OpenAIRE

    Saul, Peter D.

    1985-01-01

    General practitioners' access to remote data bases using microcomputers is increasing, making even the most obscure information readily available. Some of the systems available to general practitioners in the UK are described and the methods of access are outlined. General practitioners should be aware of the advances in technology; data bases are increasing in size, the cost of access is falling and their use is becoming easier.

  20. Design of joints in steel and composite structures Eurocode 3 : design of steel structures : part 1-8 : design of joints, Eurocode 4 : design of composite steel and concrete structures : part 1-1 : general rules and rules for buildings

    CERN Document Server

    Jaspart, Jean-Pierre

    2016-01-01

    This book details the basic concepts and the design rules included in Eurocode 3 Design of steel structures Part 1-8 Design of joints. Joints in composite construction are also addressed through references to Eurocode 4 Design of composite steel and concrete structures Part 1-1 General rules and rules for buildings. Attention has to be duly paid to the joints when designing a steel or composite structure, in terms of the global safety of the construction, and also in terms of the overall cost, including fabrication, transportation and erection. Therefore, in this book, the design of the joints themselves is widely detailed, and aspects of selection of joint configuration and integration of the joints into the analysis and the design process of the whole construction are also fully covered. Connections using mechanical fasteners, welded connections, simple joints, moment-resisting joints and lattice girder joints are considered. Various joint configurations are treated, including beam-to-column, beam-to-beam, ...

  1. Understanding the general packing rearrangements required for successful template based modeling of protein structure from a CASP experiment.

    Science.gov (United States)

    Day, Ryan; Joo, Hyun; Chavan, Archana C; Lennox, Kristin P; Chen, Y Ann; Dahl, David B; Vannucci, Marina; Tsai, Jerry W

    2013-02-01

    As an alternative to the common template based protein structure prediction methods based on main-chain position, a novel side-chain centric approach has been developed. Together with a Bayesian loop modeling procedure and a combination scoring function, the Stone Soup algorithm was applied to the CASP9 set of template based modeling targets. Although the method did not generate as large of perturbations to the template structures as necessary, the analysis of the results gives unique insights into the differences in packing between the target structures and their templates. Considerable variation in packing is found between target and template structures even when the structures are close, and this variation is found due to 2 and 3 body packing interactions. Outside the inherent restrictions in packing representation of the PDB, the first steps in correctly defining those regions of variable packing have been mapped primarily to local interactions, as the packing at the secondary and tertiary structure are largely conserved. Of the scoring functions used, a loop scoring function based on water structure exhibited some promise for discrimination. These results present a clear structural path for further development of a side-chain centered approach to template based modeling. Copyright © 2012 Elsevier Ltd. All rights reserved.

  2. Semi-structured interview is a reliable and feasible tool for selection of doctors for general practice specialist training

    DEFF Research Database (Denmark)

    Isaksen, Jesper; Hertel, Niels Thomas; Kjær, Niels Kristian

    2013-01-01

    In order to optimise the selection process for admission to specialist training in family medicine, we developed a new design for structured applications and selection interviews. The design contains semi-structured interviews, which combine individualised elements from the applications...... with standardised behaviour-based questions. This paper describes the design of the tool, and offers reflections concerning its acceptability, reliability and feasibility....

  3. Genome accessibility is widely preserved and locally modulated during mitosis.

    Science.gov (United States)

    Hsiung, Chris C-S; Morrissey, Christapher S; Udugama, Maheshi; Frank, Christopher L; Keller, Cheryl A; Baek, Songjoon; Giardine, Belinda; Crawford, Gregory E; Sung, Myong-Hee; Hardison, Ross C; Blobel, Gerd A

    2015-02-01

    Mitosis entails global alterations to chromosome structure and nuclear architecture, concomitant with transient silencing of transcription. How cells transmit transcriptional states through mitosis remains incompletely understood. While many nuclear factors dissociate from mitotic chromosomes, the observation that certain nuclear factors and chromatin features remain associated with individual loci during mitosis originated the hypothesis that such mitotically retained molecular signatures could provide transcriptional memory through mitosis. To understand the role of chromatin structure in mitotic memory, we performed the first genome-wide comparison of DNase I sensitivity of chromatin in mitosis and interphase, using a murine erythroblast model. Despite chromosome condensation during mitosis visible by microscopy, the landscape of chromatin accessibility at the macromolecular level is largely unaltered. However, mitotic chromatin accessibility is locally dynamic, with individual loci maintaining none, some, or all of their interphase accessibility. Mitotic reduction in accessibility occurs primarily within narrow, highly DNase hypersensitive sites that frequently coincide with transcription factor binding sites, whereas broader domains of moderate accessibility tend to be more stable. In mitosis, proximal promoters generally maintain their accessibility more strongly, whereas distal regulatory elements tend to lose accessibility. Large domains of DNA hypomethylation mark a subset of promoters that retain accessibility during mitosis and across many cell types in interphase. Erythroid transcription factor GATA1 exerts site-specific changes in interphase accessibility that are most pronounced at distal regulatory elements, but has little influence on mitotic accessibility. We conclude that features of open chromatin are remarkably stable through mitosis, but are modulated at the level of individual genes and regulatory elements. © 2015 Hsiung et al.; Published by

  4. Vehicle barrier with access delay

    Science.gov (United States)

    Swahlan, David J; Wilke, Jason

    2013-09-03

    An access delay vehicle barrier for stopping unauthorized entry into secure areas by a vehicle ramming attack includes access delay features for preventing and/or delaying an adversary from defeating or compromising the barrier. A horizontally deployed barrier member can include an exterior steel casing, an interior steel reinforcing member and access delay members disposed within the casing and between the casing and the interior reinforcing member. Access delay members can include wooden structural lumber, concrete and/or polymeric members that in combination with the exterior casing and interior reinforcing member act cooperatively to impair an adversarial attach by thermal, mechanical and/or explosive tools.

  5. Telecommunication access to INIS

    International Nuclear Information System (INIS)

    Scheel, H.; Breitfeld, B.; Huebner, B.

    1983-01-01

    Proceeding from the features of on-line retrieval from the INIS data base, a description is given of the technical and organizational conditions established by the national INIS Centre of the GDR in using the INIS direct access service. Data are presented on the structure of search queries, retrieval precision, and connect time to the computer. Experience has shown that efficient dialogue searching necessitates the searcher's skill and familiarity with the system. (author)

  6. Matched filtering Generalized Phase Contrast using binary phase for dynamic spot- and line patterns in biophotonics and structured lighting

    DEFF Research Database (Denmark)

    Bañas, Andrew Rafael; Aabo, Thomas; Palima, Darwin

    2013-01-01

    as a combination of Generalized Phase Contrast and phase-only correlation. Such an analysis makes it convenient to optimize an mGPC system for different setup conditions. Results showing binary-only phase generation of dynamic spot arrays and line patterns are presented. © 201 Optical Society of America...

  7. Examining the Factor Structure and Discriminant Validity of the 12-Item General Health Questionnaire (GHQ-12) Among Spanish Postpartum Women

    Science.gov (United States)

    Aguado, Jaume; Campbell, Alistair; Ascaso, Carlos; Navarro, Purificacion; Garcia-Esteve, Lluisa; Luciano, Juan V.

    2012-01-01

    In this study, the authors tested alternative factor models of the 12-item General Health Questionnaire (GHQ-12) in a sample of Spanish postpartum women, using confirmatory factor analysis. The authors report the results of modeling three different methods for scoring the GHQ-12 using estimation methods recommended for categorical and binary data.…

  8. Relaxation of structural parameters and potential coefficients of nonrigid molecules. General symmetry properties and application to ab initio study of 1,2-difluoroethane

    Science.gov (United States)

    Ha, T.-K.; Günthard, H. H.

    1989-07-01

    Structural parameters like bond length, bond angles, etc. and harmonic and anharmonic potential coefficients of molecules with internal rotation, inversion or puckering modes are generally assumed to vary with the large amplitude internal coordinates in a concerted manner (relaxation). Taking the coordinate vectors of the nuclear configuration of semirigid molecules with relaxation (SRMRs) as functions of relaxing structural parameters and finite amplitude internal coordinate, the isometric group of SRMRs is discussed and the irreducible representations of the latter are shown to classify into engendered and nonengendered ones. On this basis a concept of equivalent sets of nuclei SRMRs is introduced and an analytical expression is derived which defines the most general functional form of relaxation increments of all common types of structural parameters compatible with isometric symmetry. This formula is shown to be a close analog of an analytical expression defining the transformations induced by the isometric group of infinitesimal internal coordinates associated with typical structural parameters. Furthermore analogous formulae are given for the most general form of the relaxation of harmonic potential coefficients as a function of finite internal coordinates. The general relations are illustrated by ab initio calculations for 1,2-difluoroethane at the MP4/DZP//HF/4-31G* level for twelve values of the dihedral angle including complete structure optimization. The potential to internal rotation is found to be in essential agreement with experimentally derived data. For a complete set of ab initio structural parameters the associated relaxation increments are represented as Fourier series, which are shown to confirm the form predicted by the general formula and the isometric group of 1,2-difluoroethane. Depending on type of the structural parameters (bond length, bond angles, etc.), the associated relaxation increments appear to follow some simple rules. Similarly

  9. ProtDCal: A program to compute general-purpose-numerical descriptors for sequences and 3D-structures of proteins.

    Science.gov (United States)

    Ruiz-Blanco, Yasser B; Paz, Waldo; Green, James; Marrero-Ponce, Yovani

    2015-05-16

    The exponential growth of protein structural and sequence databases is enabling multifaceted approaches to understanding the long sought sequence-structure-function relationship. Advances in computation now make it possible to apply well-established data mining and pattern recognition techniques to these data to learn models that effectively relate structure and function. However, extracting meaningful numerical descriptors of protein sequence and structure is a key issue that requires an efficient and widely available solution. We here introduce ProtDCal, a new computational software suite capable of generating tens of thousands of features considering both sequence-based and 3D-structural descriptors. We demonstrate, by means of principle component analysis and Shannon entropy tests, how ProtDCal's sequence-based descriptors provide new and more relevant information not encoded by currently available servers for sequence-based protein feature generation. The wide diversity of the 3D-structure-based features generated by ProtDCal is shown to provide additional complementary information and effectively completes its general protein encoding capability. As demonstration of the utility of ProtDCal's features, prediction models of N-linked glycosylation sites are trained and evaluated. Classification performance compares favourably with that of contemporary predictors of N-linked glycosylation sites, in spite of not using domain-specific features as input information. ProtDCal provides a friendly and cross-platform graphical user interface, developed in the Java programming language and is freely available at: http://bioinf.sce.carleton.ca/ProtDCal/ . ProtDCal introduces local and group-based encoding which enhances the diversity of the information captured by the computed features. Furthermore, we have shown that adding structure-based descriptors contributes non-redundant additional information to the features-based characterization of polypeptide systems. This

  10. Structural and Phylogenetic Analysis of Rhodobacter capsulatus NifF: Uncovering General Features of Nitrogen-fixation (nif-Flavodoxins

    Directory of Open Access Journals (Sweden)

    Inmaculada Pérez-Dorado

    2013-01-01

    Full Text Available Analysis of the crystal structure of NifF from Rhodobacter capsulatus and its homologues reported so far reflects the existence of unique structural features in nif flavodoxins: a leucine at the re face of the isoalloxazine, an eight-residue insertion at the C-terminus of the 50’s loop and a remarkable difference in the electrostatic potential surface with respect to non-nif flavodoxins. A phylogenetic study on 64 sequences from 52 bacterial species revealed four clusters, including different functional prototypes, correlating the previously defined as “short-chain” with the firmicutes flavodoxins and the “long-chain” with gram-negative species. The comparison of Rhodobacter NifF structure with other bacterial flavodoxin prototypes discloses the concurrence of specific features of these functional electron donors to nitrogenase.

  11. Structural and phylogenetic analysis of Rhodobacter capsulatus NifF: uncovering general features of nitrogen-fixation (nif)-flavodoxins.

    Science.gov (United States)

    Pérez-Dorado, Inmaculada; Bortolotti, Ana; Cortez, Néstor; Hermoso, Juan A

    2013-01-09

    Analysis of the crystal structure of NifF from Rhodobacter capsulatus and its homologues reported so far reflects the existence of unique structural features in nif flavodoxins: a leucine at the re face of the isoalloxazine, an eight-residue insertion at the C-terminus of the 50's loop and a remarkable difference in the electrostatic potential surface with respect to non-nif flavodoxins. A phylogenetic study on 64 sequences from 52 bacterial species revealed four clusters, including different functional prototypes, correlating the previously defined as "short-chain" with the firmicutes flavodoxins and the "long-chain" with gram-negative species. The comparison of Rhodobacter NifF structure with other bacterial flavodoxin prototypes discloses the concurrence of specific features of these functional electron donors to nitrogenase.

  12. Evaluation of aerodynamic characteristics of a coupled fluid-structure system using generalized Bernoulli's principle: An application to vocal folds vibration.

    Science.gov (United States)

    Zhang, Lucy T; Yang, Jubiao

    2016-12-01

    In this work we explore the aerodynamics flow characteristics of a coupled fluid-structure interaction system using a generalized Bernoulli equation derived directly from the Cauchy momentum equations. Unlike the conventional Bernoulli equation where incompressible, inviscid, and steady flow conditions are assumed, this generalized Bernoulli equation includes the contributions from compressibility, viscous, and unsteadiness, which could be essential in defining aerodynamic characteristics. The application of the derived Bernoulli's principle is on a fully-coupled fluid-structure interaction simulation of the vocal folds vibration. The coupled system is simulated using the immersed finite element method where compressible Navier-Stokes equations are used to describe the air and an elastic pliable structure to describe the vocal fold. The vibration of the vocal fold works to open and close the glottal flow. The aerodynamics flow characteristics are evaluated using the derived Bernoulli's principles for a vibration cycle in a carefully partitioned control volume based on the moving structure. The results agree very well to experimental observations, which validate the strategy and its use in other types of flow characteristics that involve coupled fluid-structure interactions.

  13. Evaluation of aerodynamic characteristics of a coupled fluid-structure system using generalized Bernoulli’s principle: An application to vocal folds vibration

    Science.gov (United States)

    Zhang, Lucy T.; Yang, Jubiao

    2017-01-01

    In this work we explore the aerodynamics flow characteristics of a coupled fluid-structure interaction system using a generalized Bernoulli equation derived directly from the Cauchy momentum equations. Unlike the conventional Bernoulli equation where incompressible, inviscid, and steady flow conditions are assumed, this generalized Bernoulli equation includes the contributions from compressibility, viscous, and unsteadiness, which could be essential in defining aerodynamic characteristics. The application of the derived Bernoulli’s principle is on a fully-coupled fluid-structure interaction simulation of the vocal folds vibration. The coupled system is simulated using the immersed finite element method where compressible Navier-Stokes equations are used to describe the air and an elastic pliable structure to describe the vocal fold. The vibration of the vocal fold works to open and close the glottal flow. The aerodynamics flow characteristics are evaluated using the derived Bernoulli’s principles for a vibration cycle in a carefully partitioned control volume based on the moving structure. The results agree very well to experimental observations, which validate the strategy and its use in other types of flow characteristics that involve coupled fluid-structure interactions. PMID:29527541

  14. Generalized Superconductivity. Generalized Levitation

    International Nuclear Information System (INIS)

    Ciobanu, B.; Agop, M.

    2004-01-01

    In the recent papers, the gravitational superconductivity is described. We introduce the concept of generalized superconductivity observing that any nongeodesic motion and, in particular, the motion in an electromagnetic field, can be transformed in a geodesic motion by a suitable choice of the connection. In the present paper, the gravitoelectromagnetic London equations have been obtained from the generalized Helmholtz vortex theorem using the generalized local equivalence principle. In this context, the gravitoelectromagnetic Meissner effect and, implicitly, the gravitoelectromagnetic levitation are given. (authors)

  15. A generalized modal shock spectra method for spacecraft loads analysis. [internal loads in a spacecraft structure subjected to a dynamic launch environment

    Science.gov (United States)

    Trubert, M.; Salama, M.

    1979-01-01

    Unlike an earlier shock spectra approach, generalization permits an accurate elastic interaction between the spacecraft and launch vehicle to obtain accurate bounds on the spacecraft response and structural loads. In addition, the modal response from a previous launch vehicle transient analysis with or without a dummy spacecraft - is exploited to define a modal impulse as a simple idealization of the actual forcing function. The idealized modal forcing function is then used to derive explicit expressions for an estimate of the bound on the spacecraft structural response and forces. Greater accuracy is achieved with the present method over the earlier shock spectra, while saving much computational effort over the transient analysis.

  16. A Comuputerized DRBEM model for generalized magneto-thermo-visco-elastic stress waves in functionally graded anisotropic thin film/substrate structures

    Directory of Open Access Journals (Sweden)

    Mohamed Abdelsabour Fahmy

    Full Text Available A numerical computer model, based on the dual reciprocity boundary element method (DRBEM for studying the generalized magneto-thermo-visco-elastic stress waves in a rotating functionally graded anisotropic thin film/substrate structure under pulsed laser irradiation is established. An implicit-implicit staggered algorithm was proposed and implemented for use with the DRBEM to get the solution for the temperature, displacement components and thermal stress components through the structure thickness. A comparison of the results for different theories is presented in the presence and absence of rotation. Some numerical results that demonstrate the validity of the proposed method are also presented.

  17. Structure Assembly by a Heterogeneous Team of Robots Using State Estimation, Generalized Joints, and Mobile Parallel Manipulators

    Science.gov (United States)

    Komendera, Erik E.; Adhikari, Shaurav; Glassner, Samantha; Kishen, Ashwin; Quartaro, Amy

    2017-01-01

    Autonomous robotic assembly by mobile field robots has seen significant advances in recent decades, yet practicality remains elusive. Identified challenges include better use of state estimation to and reasoning with uncertainty, spreading out tasks to specialized robots, and implementing representative joining methods. This paper proposes replacing 1) self-correcting mechanical linkages with generalized joints for improved applicability, 2) assembly serial manipulators with parallel manipulators for higher precision and stability, and 3) all-in-one robots with a heterogeneous team of specialized robots for agent simplicity. This paper then describes a general assembly algorithm utilizing state estimation. Finally, these concepts are tested in the context of solar array assembly, requiring a team of robots to assemble, bond, and deploy a set of solar panel mockups to a backbone truss to an accuracy not built into the parts. This paper presents the results of these tests.

  18. Myristoylation as a general method for immobilization and alignment of soluble proteins for solid-state NMR structural studies

    International Nuclear Information System (INIS)

    Mesleh, M.F.; Valentine, K.G.; Opella, S.J.; Louis, J.M.; Gronenborn, A.M.

    2003-01-01

    N-terminal myristoylation of the immunoglobulin-binding domain of protein G (GB1) from group G Streptococcus provides the means to bind the protein to aligned phospholipid bilayers for solid-state NMR structural studies. The myristoylated protein is immobilized by its interactions with bilayers, and the sample alignment enables orientationally dependent 15 N chemical shifts and 1 H- 15 N-dipolar couplings to be measured. Spectra calculated for the average solution NMR structure of the protein at various orientations with respect to the magnetic field direction were compared to the experimental spectrum. The best fit identified the orientation of the myristoylated protein on the lipid bilayers, and demonstrated that the protein adopts a similar structure in both its myristoylated and non-myristoylated forms, and that the structure is not grossly distorted by its interaction with the phosholipid bilayer surface or by its location in the restricted aqueous space between bilayer leaflets. The protein is oriented such that its charged sides face the phosphatidylcholine headgroups of the lipids with the single amphiphilic helix running parallel to the bilayer surface

  19. General aspects of slip from technique in the construction of containment structure of the Narora Atomic Power Station

    International Nuclear Information System (INIS)

    Tilak, M.M.

    1975-01-01

    The paper describes one of the modern techniques of construction methods, i.e. use of slip form technique. Important features in adopting the above technique and its impact on construction aspects and design parameters in respect of containment structure are briefly discussed. (author)

  20. Associations between MRI-defined structural pathology and generalized and localized knee pain - the Oulu Knee Osteoarthritis study.

    Science.gov (United States)

    Kaukinen, P; Podlipská, J; Guermazi, A; Niinimäki, J; Lehenkari, P; Roemer, F W; Nieminen, M T; Koski, J M; Arokoski, J P A; Saarakkala, S

    2016-09-01

    To determine the associations between multi-feature structural pathology assessed using magnetic resonance imaging (MRI) and the presence of knee pain, and to determine the associations between the locations of structural changes and different knee pain patterns. Eighty symptomatic subjects with knee pain and suspicion or diagnosis of knee OA and 63 asymptomatic subjects underwent knee MRI. Severity of structural changes was graded by MRI Osteoarthritis Knee Score (MOAKS) in separate knee locations. The associations between cartilage damage, bone marrow lesions (BMLs), osteophytes, Hoffa's synovitis, effusion-synovitis, meniscal damage and structural pathologies in ligaments, tendons and bursas and both the presence of pain and the knee pain patterns were assessed. The presence of Hoffa's synovitis (adjusted RR 1.6, 95% CI 1.2-1.3) and osteophytes in any region (2.07, 1.19-3.60) was significantly associated with the presence of pain. Any Hoffa's synovitis was associated with patellar pain (adjusted RR 4.70, 95% CI 1.19-3.60) and moderate-to-severe Hoffa's synovitis with diffuse pain (2.25, 1.13-4.50). Medial knee pain was associated with cartilage loss in the medial tibia (adjusted RR 2.66, 95% CI 1.22-5.80), osteophytes in the medial tibia (2.66, 1.17-6.07) and medial femur (2.55, 1.07-6.09), medial meniscal maceration (2.20, 1.01-4.79) and anterior meniscal extrusions (2.78, 1.14-6.75). Hoffa's synovitis and osteophytes were strongly associated with the presence of knee pain. Medial pain was associated most often with medially located structural pathologies. Copyright © 2016 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.

  1. Experimental studies of generalized parton distributions

    International Nuclear Information System (INIS)

    Kabuss, E.M.

    2014-01-01

    Generalized parton distributions (GPD) provide a new way to study the nucleon structure. Experimentally they can be accessed using hard exclusive processes such as deeply virtual Compton scattering and meson production. First insights to GPDs were already obtained from measurements at DESY, JLAB and CERN, while new ambitious studies are planned at the upgraded JLAB at 12 GeV and at CERN. Here, some emphasis will be put onto the planned COMPASS II programme. (author)

  2. 47 CFR 15.609 - Marketing of Access BPL equipment.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 1 2010-10-01 2010-10-01 false Marketing of Access BPL equipment. 15.609 Section 15.609 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL RADIO FREQUENCY DEVICES Access Broadband Over Power Line (Access BPL) § 15.609 Marketing of Access BPL equipment. The marketing of Access...

  3. Access to Research Inputs

    DEFF Research Database (Denmark)

    Czarnitzki, Dirk; Grimpe, Christoph; Pellens, Maikel

    2015-01-01

    The viability of modern open science norms and practices depends on public disclosure of new knowledge, methods, and materials. However, increasing industry funding of research can restrict the dissemination of results and materials. We show, through a survey sample of 837 German scientists in life...... sciences, natural sciences, engineering, and social sciences, that scientists who receive industry funding are twice as likely to deny requests for research inputs as those who do not. Receiving external funding in general does not affect denying others access. Scientists who receive external funding...... of any kind are, however, 50 % more likely to be denied access to research materials by others, but this is not affected by being funded specifically by industry...

  4. Access to Research Inputs

    DEFF Research Database (Denmark)

    Czarnitzki, Dirk; Grimpe, Christoph; Pellens, Maikel

    The viability of modern open science norms and practices depend on public disclosure of new knowledge, methods, and materials. However, increasing industry funding of research can restrict the dissemination of results and materials. We show, through a survey sample of 837 German scientists in life...... sciences, natural sciences, engineering, and social sciences, that scientists who receive industry funding are twice as likely to deny requests for research inputs as those who do not. Receiving external funding in general does not affect denying others access. Scientists who receive external funding...... of any kind are, however, 50% more likely to be denied access to research materials by others, but this is not affected by being funded specifically by industry....

  5. General chemistry

    International Nuclear Information System (INIS)

    Kwon, Yeong Sik; Lee, Dong Seop; Ryu, Haung Ryong; Jang, Cheol Hyeon; Choi, Bong Jong; Choi, Sang Won

    1993-07-01

    The book concentrates on the latest general chemistry, which is divided int twenty-three chapters. It deals with basic conception and stoichiometry, nature of gas, structure of atoms, quantum mechanics, symbol and structure of an electron of ion and molecule, chemical thermodynamics, nature of solid, change of state and liquid, properties of solution, chemical equilibrium, solution and acid-base, equilibrium of aqueous solution, electrochemistry, chemical reaction speed, molecule spectroscopy, hydrogen, oxygen and water, metallic atom; 1A, IIA, IIIA, carbon and atom IVA, nonmetal atom and an inert gas, transition metals, lanthanons, and actinoids, nuclear properties and radioactivity, biochemistry and environment chemistry.

  6. Multilocality and fusion rules on the generalized structure functions in two-dimensional and three-dimensional Navier-Stokes turbulence.

    Science.gov (United States)

    Gkioulekas, Eleftherios

    2016-09-01

    Using the fusion-rules hypothesis for three-dimensional and two-dimensional Navier-Stokes turbulence, we generalize a previous nonperturbative locality proof to multiple applications of the nonlinear interactions operator on generalized structure functions of velocity differences. We call this generalization of nonperturbative locality to multiple applications of the nonlinear interactions operator "multilocality." The resulting cross terms pose a new challenge requiring a new argument and the introduction of a new fusion rule that takes advantage of rotational symmetry. Our main result is that the fusion-rules hypothesis implies both locality and multilocality in both the IR and UV limits for the downscale energy cascade of three-dimensional Navier-Stokes turbulence and the downscale enstrophy cascade and inverse energy cascade of two-dimensional Navier-Stokes turbulence. We stress that these claims relate to nonperturbative locality of generalized structure functions on all orders and not the term-by-term perturbative locality of diagrammatic theories or closure models that involve only two-point correlation and response functions.

  7. Generalizing entanglement

    Science.gov (United States)

    Jia, Ding

    2017-12-01

    The expected indefinite causal structure in quantum gravity poses a challenge to the notion of entanglement: If two parties are in an indefinite causal relation of being causally connected and not, can they still be entangled? If so, how does one measure the amount of entanglement? We propose to generalize the notions of entanglement and entanglement measure to address these questions. Importantly, the generalization opens the path to study quantum entanglement of states, channels, networks, and processes with definite or indefinite causal structure in a unified fashion, e.g., we show that the entanglement distillation capacity of a state, the quantum communication capacity of a channel, and the entanglement generation capacity of a network or a process are different manifestations of one and the same entanglement measure.

  8. Chronic Alcohol Abuse Leads to Low Bone Mass with No General Loss of Bone Structure or Bone Mechanical Strength

    DEFF Research Database (Denmark)

    Ulhøi, Maiken Parm; Meldgaard, Karoline; Steiniche, Torben

    2017-01-01

    Chronic alcohol abuse (CAA) has deleterious effects on skeletal health. This study examined the impact of CAA on bone with regard to bone density, structure, and strength. Bone specimens from 42 individuals with CAA and 42 individuals without alcohol abuse were obtained at autopsy. Dual-energy X......-ray absorptiometry (DEXA), compression testing, ashing, and bone histomorphometry were performed. Individuals with CAA had significantly lower bone mineral density (BMD) in the femoral neck and significantly lower bone volume demonstrated by thinner trabeculae, decreased extent of osteoid surfaces, and lower mean...... wall thickness of trabecular osteons compared to individuals without alcohol abuse. No significant difference was found for bone strength and structure. Conclusion: CAA leads to low bone mass due to a decrease in bone formation but with no destruction of bone architecture nor a decrease in bone...

  9. Structure and interaction in dense colloidal systems: evaluation of scattering data by the generalized indirect Fourier transformation method

    International Nuclear Information System (INIS)

    Fritz, Gerhard; Glatter, Otto

    2006-01-01

    The generalized indirect Fourier transformation (GIFT) technique is a versatile tool for the evaluation of small angle scattering data. It does not depend on models for the size and shape of the particles and requires model assumptions only for the interaction effects that are typically not as sensitive to the details of the assumptions. We review here the development of the technique from its inception, focusing on the included interaction models for hard, charged and attractive spheres, and lamellae. A considerable number of applications has also been reported ranging from surfactants, emulsions, microemulsions, food science, and ceramics to melts and block-copolymers

  10. Differences in the structure of outpatient diabetes care between endocrinologist-led and general physician-led services.

    LENUS (Irish Health Repository)

    O Donnell, Máire

    2013-11-25

    Despite a shift in diabetes care internationally from secondary to primary care, diabetes care in the Republic of Ireland remains very hospital-based. Significant variation in the facilities and resources available to hospitals providing outpatient diabetes care have been reported in the UK. The aim of this study was to ascertain the structure of outpatient diabetes care in public hospitals in the Republic of Ireland and whether differences existed in services provided across hospitals.

  11. Comportamiento estructural y criterios de diseño de los puentes extradosados: visión general y estado del arte Structural behavior and design criteria of extradosed bridges: general insight and state of the art

    Directory of Open Access Journals (Sweden)

    José Benjumea

    2010-01-01

    Full Text Available Durante los últimos 10 años, los puentes extradosados se han convertido en una solución estructural atractiva alrededor del mundo, gracias a los buenos resultados obtenidos con las primeras realizaciones en Japón. Esta nueva tipología, reconocida generalmente como una solución intermedia entre los puentes atirantados y los de pretensado de viga cajón construidos por voladizos sucesivos, se ha convertido en una opción interesante. Por consiguiente, dado el interés que hoy en día existe alrededor de este tipo de puente, en este trabajo se presenta el contexto histórico que describe su origen, y se exponen la influencia de los principales elementos estructurales en el comportamiento del puente, y los criterios de diseño que han sido propuestos por investigadores en el tema. De esta manera, se espera ofrecer una visión general de la concepción y el comportamiento estructural de los puentes extradosados para que sea considerada una alternativa más de tipología estructural de puentes en nuestro medio.Over the past 10 years, Extradosed bridges have become an attractive structural type around the world, due to the good results obtained with the first bridges constructed in Japan. This new typology, generally recognized as an intermediate solution between cable stayed bridges and cantilever constructed prestressed box-girder bridges, because these take advantages of design and constructions methods of the other two typologies, has become an interesting option. Therefore, given the interest that exist about this type of bridge, in this paper the historical context that describes its origin, the influence of the principal structural elements and the design criteria proposed by researchers are presented. In this way it is expected to offer a general insight into the design conception and structural behavior of Extradosed Bridges, so that they may be considered as an alternative structure for bridges in the Americas.

  12. A covariance correction that accounts for correlation estimation to improve finite-sample inference with generalized estimating equations: A study on its applicability with structured correlation matrices.

    Science.gov (United States)

    Westgate, Philip M

    2016-01-01

    When generalized estimating equations (GEE) incorporate an unstructured working correlation matrix, the variances of regression parameter estimates can inflate due to the estimation of the correlation parameters. In previous work, an approximation for this inflation that results in a corrected version of the sandwich formula for the covariance matrix of regression parameter estimates was derived. Use of this correction for correlation structure selection also reduces the over-selection of the unstructured working correlation matrix. In this manuscript, we conduct a simulation study to demonstrate that an increase in variances of regression parameter estimates can occur when GEE incorporates structured working correlation matrices as well. Correspondingly, we show the ability of the corrected version of the sandwich formula to improve the validity of inference and correlation structure selection. We also study the relative influences of two popular corrections to a different source of bias in the empirical sandwich covariance estimator.

  13. Semi-structured interview is a reliable and feasible tool for selection of doctors for general practice specialist training.

    Science.gov (United States)

    Isaksen, Jesper Hesselbjerg; Hertel, Niels Thomas; Kjær, Niels Kristian

    2013-09-01

    In order to optimise the selection process for admission to specialist training in family medicine, we developed a new design for structured applications and selection interviews. The design contains semi-structured interviews, which combine individualised elements from the applications with standardised behaviour-based questions. This paper describes the design of the tool, and offers reflections concerning its acceptability, reliability and feasibility. We used a combined quantitative and qualitative evaluation method. Ratings obtained by the applicants in two selection rounds were analysed for reliability and generalisability using the GENOVA programme. Applicants and assessors were randomly selected for individual semi-structured in-depth interviews. The qualitative data were analysed in accordance with the grounded theory method. Quantitative analysis yielded a high Cronbach's alpha of 0.97 for the first round and 0.90 for the second round, and a G coefficient of the first round of 0.74 and of the second round of 0.40. Qualitative analysis demonstrated high acceptability and fairness and it improved the assessors' judgment. Applicants reported concerns about loss of personality and some anxiety. The applicants' ability to reflect on their competences was important. The developed selection tool demonstrated an acceptable level of reliability, but only moderate generalisability. The users found that the tool provided a high degree of acceptability; it is a feasible and useful tool for -selection of doctors for specialist training if combined with work-based assessment. Studies on the benefits and drawbacks of this tool compared with other selection models are relevant. not relevant. not relevant.

  14. New insights into the correlation structure of DSM-IV depression symptoms in the general population v. subsamples of depressed individuals.

    Science.gov (United States)

    Foster, S; Mohler-Kuo, M

    2018-06-01

    Previous research failed to uncover a replicable dimensional structure underlying the symptoms of depression. We aimed to examine two neglected methodological issues in this research: (a) adjusting symptom correlations for overall depression severity; and (b) analysing general population samples v. subsamples of currently depressed individuals. Using population-based cross-sectional and longitudinal data from two nations (Switzerland, 5883 young men; USA, 2174 young men and 2244 young women) we assessed the dimensions of the nine DSM-IV depression symptoms in young adults. In each general-population sample and each subsample of currently depressed participants, we conducted a standardised process of three analytical steps, based on exploratory and confirmatory factor and bifactor analysis, to reveal any replicable dimensional structure underlying symptom correlations while controlling for overall depression severity. We found no evidence of a replicable dimensional structure across samples when adjusting symptom correlations for overall depression severity. In the general-population samples, symptoms correlated strongly and a single dimension of depression severity was revealed. Among depressed participants, symptom correlations were surprisingly weak and no replicable dimensions were identified, regardless of severity-adjustment. First, caution is warranted when considering studies assessing dimensions of depression because general population-based studies and studies of depressed individuals generate different data that can lead to different conclusions. This problem likely generalises to other models based on the symptoms' inter-relationships such as network models. Second, whereas the overall severity aligns individuals on a continuum of disorder intensity that allows non-affected individuals to be distinguished from affected individuals, the clinical evaluation and treatment of depressed individuals should focus directly on each individual's symptom profile.

  15. General general game AI

    OpenAIRE

    Togelius, Julian; Yannakakis, Georgios N.; 2016 IEEE Conference on Computational Intelligence and Games (CIG)

    2016-01-01

    Arguably the grand goal of artificial intelligence research is to produce machines with general intelligence: the capacity to solve multiple problems, not just one. Artificial intelligence (AI) has investigated the general intelligence capacity of machines within the domain of games more than any other domain given the ideal properties of games for that purpose: controlled yet interesting and computationally hard problems. This line of research, however, has so far focuse...

  16. The future of general classification

    DEFF Research Database (Denmark)

    Mai, Jens Erik

    2013-01-01

    Discusses problems related to accessing multiple collections using a single retrieval language. Surveys the concepts of interoperability and switching language. Finds that mapping between more indexing languages always will be an approximation. Surveys the issues related to general classification...... and contrasts that to special classifications. Argues for the use of general classifications to provide access to collections nationally and internationally....

  17. Insights into the Electronic Structure of Ozone and Sulfur Dioxide from Generalized Valence Bond Theory: Addition of Hydrogen Atoms.

    Science.gov (United States)

    Lindquist, Beth A; Takeshita, Tyler Y; Dunning, Thom H

    2016-05-05

    Ozone (O3) and sulfur dioxide (SO2) are valence isoelectronic species, yet their properties and reactivities differ dramatically. In particular, O3 is highly reactive, whereas SO2 is chemically relatively stable. In this paper, we investigate serial addition of hydrogen atoms to both the terminal atoms of O3 and SO2 and to the central atom of these species. It is well-known that the terminal atoms of O3 are much more amenable to bond formation than those of SO2. We show that the differences in the electronic structure of the π systems in the parent triatomic species account for the differences in the addition of hydrogen atoms to the terminal atoms of O3 and SO2. Further, we find that the π system in SO2, which is a recoupled pair bond dyad, facilitates the addition of hydrogen atoms to the sulfur atom, resulting in stable HSO2 and H2SO2 species.

  18. A production of non-strain spacing of lattice planes measurement equipment and a measurement of general structure material

    International Nuclear Information System (INIS)

    Minakawa, Nobuaki; Moriai, Atsushi; Morii, Yukio

    2001-01-01

    It is necessary to determine Δd/d in the internal stress measurement by the neutron diffraction method. Therefore, in case the non-strain spacing of lattice planes d 0 (hkl) is measured using bulk material, even though it does and attaches in a sample table length or every width and it is performing the diffraction measurement, it is difficult to determine for a true non-strain spacing of lattice planes by a processing strain, the grain-orientation, etc. It is available for the infinite thing spacing of lattice planes near non-strain condition to be measured by doing random rotation for bulk material in a beam center, and measuring an average spacing of lattice planes. Practical non-strain spacing of lattice planes measurement equipment was made, and the measurement was performed about much structure material. (author)

  19. A generally applicable lightweight method for calculating a value structure for tools and services in bioinformatics infrastructure projects.

    Science.gov (United States)

    Mayer, Gerhard; Quast, Christian; Felden, Janine; Lange, Matthias; Prinz, Manuel; Pühler, Alfred; Lawerenz, Chris; Scholz, Uwe; Glöckner, Frank Oliver; Müller, Wolfgang; Marcus, Katrin; Eisenacher, Martin

    2017-10-30

    Sustainable noncommercial bioinformatics infrastructures are a prerequisite to use and take advantage of the potential of big data analysis for research and economy. Consequently, funders, universities and institutes as well as users ask for a transparent value model for the tools and services offered. In this article, a generally applicable lightweight method is described by which bioinformatics infrastructure projects can estimate the value of tools and services offered without determining exactly the total costs of ownership. Five representative scenarios for value estimation from a rough estimation to a detailed breakdown of costs are presented. To account for the diversity in bioinformatics applications and services, the notion of service-specific 'service provision units' is introduced together with the factors influencing them and the main underlying assumptions for these 'value influencing factors'. Special attention is given on how to handle personnel costs and indirect costs such as electricity. Four examples are presented for the calculation of the value of tools and services provided by the German Network for Bioinformatics Infrastructure (de.NBI): one for tool usage, one for (Web-based) database analyses, one for consulting services and one for bioinformatics training events. Finally, from the discussed values, the costs of direct funding and the costs of payment of services by funded projects are calculated and compared. © The Author 2017. Published by Oxford University Press.

  20. An Ultrahigh Resolution Structure of TEM-1 β-Lactamase Suggests a Role for Glu166 as the General Base in Acylation

    International Nuclear Information System (INIS)

    Minasov, George; Wang, Xiaojun; Shoichet, Brian K.

    2002-01-01

    Although TEM-1 β-lactamase is among the best studied enzymes, its acylation mechanism remains controversial. To investigate this problem, the structure of TEM-1 in complex with an acylation transition-state analogue was determined at ultrahigh resolution (0.85 (angstrom)) by X-ray crystallography. The quality of the data was such as to allow for refinement to an R-factor of 9.1% and an R free of 11.2%. In the resulting structure, the electron density features were clear enough to differentiate between single and double bonds in carboxylate groups, to identify multiple conformations that are occupied by residues and loops, and to assign 70% of the protons in the protein. Unexpectedly, even at pH 8.0 where the protein was crystallized, the active site residue Glu166 is clearly protonated. This supports the hypothesis that Glu166 is the general base in the acylation half of the reaction cycle. This structure suggests that Glu166 acts through the catalytic water to activate Ser70 for nucleophilic attack on the β-lactam ring of the substrate. The hydrolytic mechanism of class A β-lactamases, such as TEM-1, appears to be symmetrical, as are the serine proteases. Apart from its mechanistic implications, this atomic resolution structure affords an unusually detailed view of the structure, dynamics, and hydrogen-bonding networks of TEM-1, which may be useful for the design of inhibitors against this key antibiotic resistance target.