Thermal stability study for candidate stainless steels of GEN IV reactors

International Nuclear Information System (INIS)

Simeg Veternikova, J.; Degmova, J.; Pekarcikova, M.; Simko, F.; Petriska, M.; Skarba, M.; Mikula, P.; Pupala, M.

2016-01-01

Highlights: • Thermal resistance of advanced stainless steels were observed at 1000 °C. • GEN IV candidate steels were confronted to classic AISI steels. • ODS AISI 316 has weaker thermal resistance than classic AISI steel. • Ferritic ODS steels and NF 709 has better thermal resistance than AISI steels. - Abstract: Candidate stainless steels for GEN IV reactors were investigated in term of thermal and corrosion stability at high temperatures. New austenitic steel (NF 709), austenitic ODS steel (ODS 316) and two ferritic ODS steels (MA 956 and MA 957) were exposed to around 1000 °C in inert argon atmosphere at pressure of ∼8 MPa. The steels were further studied in a light of vacancy defects presence by positron annihilation spectroscopy and their thermal resistance was confronted to classic AISI steels. The thermal strain supported a creation of oxide layers observed by scanning electron microscopy (SEM).

Thermal stability study for candidate stainless steels of GEN IV reactors

Energy Technology Data Exchange (ETDEWEB)

Simeg Veternikova, J., E-mail: jana.veternikova@stuba.sk [Institute of Nuclear and Physical Engineering, Faculty of Electrical and Information Technology, Slovak University of Technology, Ilkovicova 3, 812 19 Bratislava (Slovakia); Degmova, J. [Institute of Nuclear and Physical Engineering, Faculty of Electrical and Information Technology, Slovak University of Technology, Ilkovicova 3, 812 19 Bratislava (Slovakia); Pekarcikova, M. [Institute of Materials Science, Faculty of Materials Science and Technology, Slovak University of Technology, Paulinska 16, 917 24 Trnava (Slovakia); Simko, F. [Department of Molten Salts, Institute of Inorganic Chemistry, Slovak Academy of Sciences, Dubravska cesta 9, 845 36 Bratislava (Slovakia); Petriska, M. [Institute of Nuclear and Physical Engineering, Faculty of Electrical and Information Technology, Slovak University of Technology, Ilkovicova 3, 812 19 Bratislava (Slovakia); Skarba, M. [Slovak University of Technology, Vazovova 5, 812 43 Bratislava (Slovakia); Mikula, P. [Institute of Nuclear and Physical Engineering, Faculty of Electrical and Information Technology, Slovak University of Technology, Ilkovicova 3, 812 19 Bratislava (Slovakia); Pupala, M. [Department of Molten Salts, Institute of Inorganic Chemistry, Slovak Academy of Sciences, Dubravska cesta 9, 845 36 Bratislava (Slovakia)

2016-11-30

Highlights: • Thermal resistance of advanced stainless steels were observed at 1000 °C. • GEN IV candidate steels were confronted to classic AISI steels. • ODS AISI 316 has weaker thermal resistance than classic AISI steel. • Ferritic ODS steels and NF 709 has better thermal resistance than AISI steels. - Abstract: Candidate stainless steels for GEN IV reactors were investigated in term of thermal and corrosion stability at high temperatures. New austenitic steel (NF 709), austenitic ODS steel (ODS 316) and two ferritic ODS steels (MA 956 and MA 957) were exposed to around 1000 °C in inert argon atmosphere at pressure of ∼8 MPa. The steels were further studied in a light of vacancy defects presence by positron annihilation spectroscopy and their thermal resistance was confronted to classic AISI steels. The thermal strain supported a creation of oxide layers observed by scanning electron microscopy (SEM).

Gen IV Materials Handbook Functionalities and Operation

International Nuclear Information System (INIS)

Ren, Weiju

2009-01-01

This document is prepared for navigation and operation of the Gen IV Materials Handbook, with architecture description and new user access initiation instructions. Development rationale and history of the Handbook is summarized. The major development aspects, architecture, and design principles of the Handbook are briefly introduced to provide an overview of its past evolution and future prospects. Detailed instructions are given with examples for navigating the constructed Handbook components and using the main functionalities. Procedures are provided in a step-by-step fashion for Data Upload Managers to upload reports and data files, as well as for new users to initiate Handbook access.

Gen IV Materials Handbook Functionalities and Operation

Energy Technology Data Exchange (ETDEWEB)

Ren, Weiju [ORNL

2009-12-01

This document is prepared for navigation and operation of the Gen IV Materials Handbook, with architecture description and new user access initiation instructions. Development rationale and history of the Handbook is summarized. The major development aspects, architecture, and design principles of the Handbook are briefly introduced to provide an overview of its past evolution and future prospects. Detailed instructions are given with examples for navigating the constructed Handbook components and using the main functionalities. Procedures are provided in a step-by-step fashion for Data Upload Managers to upload reports and data files, as well as for new users to initiate Handbook access.

DEVELOPMENT OF RISK-BASED AND TECHNOLOGY-INDEPENDENT SAFETY CRITERIA FOR GENERATION IV SYSTEMS

Energy Technology Data Exchange (ETDEWEB)

William E. Kastenberg; Edward Blandford; Lance Kim

2009-03-31

This project has developed quantitative safety goals for Generation IV (Gen IV) nuclear energy systems. These safety goals are risk based and technology independent. The foundations for a new approach to risk analysis has been developed, along with a new operational definition of risk. This project has furthered the current state-of-the-art by developing quantitative safety goals for both Gen IV reactors and for the overall Gen IV nuclear fuel cycle. The risk analysis approach developed will quantify performance measures, characterize uncertainty, and address a more comprehensive view of safety as it relates to the overall system. Appropriate safety criteria are necessary to manage risk in a prudent and cost-effective manner. This study is also important for government agencies responsible for managing, reviewing, and for approving advanced reactor systems because they are charged with assuring the health and safety of the public.

DEVELOPMENT OF RISK-BASED AND TECHNOLOGY-INDEPENDENT SAFETY CRITERIA FOR GENERATION IV SYSTEMS

International Nuclear Information System (INIS)

Kastenberg, William E.; Blandford, Edward; Kim, Lance

2009-01-01

This project has developed quantitative safety goals for Generation IV (Gen IV) nuclear energy systems. These safety goals are risk based and technology independent. The foundations for a new approach to risk analysis has been developed, along with a new operational definition of risk. This project has furthered the current state-of-the-art by developing quantitative safety goals for both Gen IV reactors and for the overall Gen IV nuclear fuel cycle. The risk analysis approach developed will quantify performance measures, characterize uncertainty, and address a more comprehensive view of safety as it relates to the overall system. Appropriate safety criteria are necessary to manage risk in a prudent and cost-effective manner. This study is also important for government agencies responsible for managing, reviewing, and for approving advanced reactor systems because they are charged with assuring the health and safety of the public

The status of proliferation resistance evaluation methodology development in GEN IV international forum

International Nuclear Information System (INIS)

Inoue, Naoko; Kawakubo, Yoko; Seya, Michio; Suzuki, Mitsutoshi; Kuno, Yusuke; Senzaki, Masao

2010-01-01

The Generation IV Nuclear Energy Systems International Forum (GIF) Proliferation Resistance and Physical Protection Working Group (PR and PP WG) was established in December 2002 in order to develop the PR and PP evaluation methodology for GEN IV nuclear energy systems. The methodology has been studied and established by international consensus. The PR and PP WG activities include development of the measures and metrics; establishment of the framework of PR and PP evaluation, the demonstration study using Example Sodium Fast Reactor (ESFR), which included the development of three evaluation approaches; the Case Study using ESFR and four kinds of threat scenarios; the joint study with GIF System Steering Committees (SSCs) of the six reactor design concepts; and the harmonization study with the IAEA's International Project on Innovative Nuclear Reactors and Fuel Cycles (INPRO). This paper reviews the status of GIF PR and PP studies and identifies the challenges and directions for applying the methodology to evaluate future nuclear energy systems in Japan. (author)

Reactor physics challenges in GEN-IV reactor design

Energy Technology Data Exchange (ETDEWEB)

Driscoll, Michael K.; Hejzlar, Pavel [Massachusetts Institute of Technology, MA (United States)

2005-02-15

An overview of the reactor physics aspects of GENeration Four (GEN-IV) advanced reactors is presented, emphasizing how their special requirements for enhanced sustainability, safety and economics motivates consideration of features not thoroughly analyzed in the past. The resulting concept-specific requirements for better data and methods are surveyed, and some approaches and initiatives are suggested to meet the challenges faced by the international reactor physics community. No unresolvable impediments to successful development of any of the six major types of proposed reactors are identified, given appropriate and timely devotion of resources.

Reactor physics challenges in GEN-IV reactor design

International Nuclear Information System (INIS)

Driscoll, Michael K.; Hejzlar, Pavel

2005-01-01

An overview of the reactor physics aspects of GENeration Four (GEN-IV) advanced reactors is presented, emphasizing how their special requirements for enhanced sustainability, safety and economics motivates consideration of features not thoroughly analyzed in the past. The resulting concept-specific requirements for better data and methods are surveyed, and some approaches and initiatives are suggested to meet the challenges faced by the international reactor physics community. No unresolvable impediments to successful development of any of the six major types of proposed reactors are identified, given appropriate and timely devotion of resources

Decay Heat Removal in GEN IV Gas-Cooled Fast Reactors

International Nuclear Information System (INIS)

Lap-Yan, C.; Wie, T. Y. C.

2009-01-01

The safety goal of the current designs of advanced high-temperature thermal gas-cooled reactors (HTRs) is that no core meltdown would occur in a depressurization event with a combination of concurrent safety system failures. This study focused on the analysis of passive decay heat removal (DHR) in a GEN IV direct-cycle gas-cooled fast reactor (GFR) which is based on the technology developments of the HTRs. Given the different criteria and design characteristics of the GFR, an approach different from that taken for the HTRs for passive DHR would have to be explored. Different design options based on maintaining core flow were evaluated by performing transient analysis of a depressurization accident using the system code RELAP5-3D. The study also reviewed the conceptual design of autonomous systems for shutdown decay heat removal and recommends that future work in this area should be focused on the potential for Brayton cycle DHRs.

The safety R and D for GEN-IV reactors in the European nuclear energy technology platform strategic research agenda

International Nuclear Information System (INIS)

Bruna, G.

2009-01-01

In the fall 2007 EC launched the Sustainable Nuclear Energy Technology Platform (SNE-TP). The SNE-TP governing board set-up three working groups (WG): 1) Strategic Research Agenda (SRA) WG, in charge of drafting road-maps to support research, development and demonstration for current and future NPPs; 2) Deployment Strategy (DS) WG, in charge of defining the research road-map implementation and 3) Education, Training and Knowledge management (ETKM) WG, which was aimed at issuing proposal to reinforce European education and attract young in the nuclear field. The SRA WG was mandated to prepare the SRA vision document based on the preliminary road-map sketched in the document published by the Commission earlier in 2007. The SRA WG was originally organized in 5 sub-groups covering specific topics (1) GEN II and III, III+, including Advanced LWR, 2) Advanced Fuel Cycle for waste minimization and resource optimization; 3) GEN IV Fast Systems (SFR, LFR, GFR, ADS); 4) GEN IV (V) HTR and non-electricity-production applications; 5) New Nuclear Large Research Infrastructures) and 5 other sub-groups dealing with more generic cross-cutting research activities applicable to many specific topics, namely: 1) Structural material research; 2) modeling, simulation and methods, including physical data and tools and means for qualification and validation; 3) Reactor Safety, including severe accidents and human factor; 4) Advanced Driver and Minor Actinide Fuels: science and properties; 5) Pre-normative Research, Codes and Standards.The present paper is mainly aimed at summarizing the content of the SRA Safety sub-chapter focusing on GEN-IV aspects

Conversion of actinide solutions for the production of MA bearing fuels for Gen IV fast reactor systems

International Nuclear Information System (INIS)

Fernandez, A.; McGinley, J.; Somers, J.

2008-01-01

The conversion of the solution to solid for fuels containing minor actinides for accelerator driven systems or Gen IV fast reactors cannot be made by conventional ammonia or oxalate precipitation as is the case in today's reprocessing plant. The small particle size and concomitant dust that is produced in subsequent processing steps will not permit use of these processes on industrial scale. Innovation is needed to avoid dust generating powders, and indeed to simplify the processes themselves. Two such processing routes have been developed at the JRC-ITU. The sol gel route has been used to produce fuel containing Am and Np for the SUPERFACT, TRABANT and other irradiation experiments. The infiltration process has also been established and fuels have been produced for the FUTURIX and HELIOS experiments. (authors)

Conversion of actinide solutions for the production of MA bearing fuels for Gen IV fast reactor systems

Energy Technology Data Exchange (ETDEWEB)

Fernandez, A.; McGinley, J.; Somers, J. [European Commission, Joint Research Centre, Institute for Transuranium Elements P.O.Box 2340, Karlsruhe, D-76125 (Germany)

2008-07-01

The conversion of the solution to solid for fuels containing minor actinides for accelerator driven systems or Gen IV fast reactors cannot be made by conventional ammonia or oxalate precipitation as is the case in today's reprocessing plant. The small particle size and concomitant dust that is produced in subsequent processing steps will not permit use of these processes on industrial scale. Innovation is needed to avoid dust generating powders, and indeed to simplify the processes themselves. Two such processing routes have been developed at the JRC-ITU. The sol gel route has been used to produce fuel containing Am and Np for the SUPERFACT, TRABANT and other irradiation experiments. The infiltration process has also been established and fuels have been produced for the FUTURIX and HELIOS experiments. (authors)

Level II Probabilistic Safety Analysis Methodology for the Application to GEN-IV Sodium-cooled Fast Reactor

International Nuclear Information System (INIS)

Park, S. Y.; Kim, T. W.; Han, S. H.; Jeong, H. Y.

2010-03-01

The Korea Atomic Energy Research Institute (KAERI) has been developing liquid metal reactor (LMR) design technologies under a National Nuclear R and D Program. Nevertheless, there is no experience of the probabilistic safety assessment (PSA) domestically for a fast reactor with the metal fuel. Therefore, the objective of this study is to establish the methodologies of risk assessment for the reference design of GEN-IV sodium fast reactor (SFR). An applicability of the PSA methodology of U. S. NRC and PRISM plant to the domestic GEN-IV SFR has been studied. The study contains a plant damage state analysis, a containment event tree analysis, and a source-term release category binning process

A preliminary safety analysis for the prototype Gen IV Sodium-Cooled Fast Reactor

Energy Technology Data Exchange (ETDEWEB)

Lee, Kwi Lim; Ha, Kwi Seok; Jeong, Jae Ho; Choi, Chi Woong; Jeong, Tae Kyeong; Ahn, Sang June; Lee, Seung Won; Chang, Won Pyo; Kang, Seok Hun; Yoo, Jae Woon [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

2016-10-15

Korea Atomic Energy Research Institute has been developing a pool-type sodium-cooled fast reactor of the Prototype Gen-IV Sodium-cooled Fast Reactor (PGSFR). To assess the effectiveness of the inherent safety features of the PGSFR, the system transients during design basis accidents and design extended conditions are analyzed with MARS-LMR and the subchannel blockage events are analyzed with MATRA-LMR-FB. In addition, the in-vessel source term is calculated based on the super-safe, small, and simple reactor methodology. The results show that the PGSFR meets safety acceptance criteria with a sufficient margin during the events and keeps accidents from deteriorating into more severe accidents.

Developing new nuclear curricula for GEN IV needs

International Nuclear Information System (INIS)

Ghitescu, P.; Pavel, G.L.

2014-01-01

States who wish to start and develop a nuclear program must take into consideration a strong proven strategy for developing a sustainable program. A complete nuclear research program must include: a good national strategy and support on the topic; strong research laboratories supported by good personnel; education component to provide sustainable and qualified workforce; national/international interest from stakeholders and governments and a well informed society. New demonstrators are foreseen for the next period to be built in Europe and skilled supporting personnel is strongly needed. Current situation in nuclear higher education with perspective will be analysed. EURATOM strongly supports development of multidisciplinary co-operational projects in order to built such novel initiatives. An example of such program supported by European Commission, ARCADIA, will be given. The project is based on the cooperation of a large number of participants all over Europe and the main purpose is to develop a road-map for Gen IV reactor. (authors)

Report on generation IV technical working group 3 : liquid metal reactors

International Nuclear Information System (INIS)

Lineberry, M. J.; Rosen, S. L.; Sagayama, Y.

2002-01-01

This paper reports on the first round of R and D roadmap activities of the Generation IV (Gen IV) Technical Working Group (TWG) 3, on liquid metal-cooled reactors. Liquid metal coolants give rise to fast spectrum systems, and thus the reactor systems considered in this TWG are all fast reactors. Gas-cooled fast reactors are considered in the context of TWG 2. As is noted in other Gen IV papers, this first round activity is termed ''screening for potential'', and includes collecting the most complete set of liquid metal reactor/fuel cycle system concepts possible and evaluating the concepts against the Gen IV principles and goals. Those concepts or concept groups that meet the Gen IV principles and which are deemed to have reasonable potential to meet the Gen IV goals will pass to the next round of evaluation. Although we sometimes use the terms ''reactor'' or ''reactor system'' by themselves, the scope of the investigation by TWG 3 includes not only the reactor systems, but very importantly the closed fuel recycle system inevitably required by fast reactors. The response to the DOE Request for Information (RFI) on liquid metal reactor/fuel cycle systems from principal investigators, laboratories, corporations, and other institutions, was robust and gratifying. Thirty three liquid metal concept descriptions, from eight different countries, were ultimately received. The variation in the scope, depth, and completeness of the responses created a significant challenge for the group, but the TWG made a very significant effort not to screen out concepts early in the process

Materials for generation-IV nuclear reactors

International Nuclear Information System (INIS)

Alvarez, M. G.

2009-01-01

Materials science and materials development are key issues for the implementation of innovative reactor systems such as those defined in the framework of the Generation IV. Six systems have been selected for Generation IV consideration: gas-cooled fast reactor, lead-cooled fast reactor, molten salt-cooled reactor, sodium-cooled fast reactor, supercritical water-cooled reactor, and very high temperature reactor. The structural materials need to resist much higher temperatures, higher neutron doses and extremely corrosive environment, which are beyond the experience of the current nuclear power plants. For this reason, the first consideration in the development of Generation-IV concepts is selection and deployment of materials that operate successfully in the aggressive operating environments expected in the Gen-IV concepts. This paper summarizes the Gen-IV operating environments and describes the various candidate materials under consideration for use in different structural applications. (author)

A Study on the Planning of Technology Development and Research for Generation IV Nuclear Energy Systems

Energy Technology Data Exchange (ETDEWEB)

Chang, Moon Hee; Kim, H. R.; Kim, H. J. and others

2005-08-15

This study aimed at the planning the domestic technology development of the Gen IV and the formulating the international collaborative project contents and executive plan for 'A Validity Assessment and Policies of the R and D of Generation IV Nuclear Energy Systems'. The results of the study include follows; - Survey of the technology state in the fields of the Gen IV system specific technologies and the common technologies, and the plans of the international collaborative research - Drawing up the executive research and development plan by the experts of the relevant technology field for the systems which Korean will participate in. - Formulating the effective conduction plan of the program reflecting the view of the experts from the industry, the university and the research institute. - Establishing the plan for estimation of the research fund and the manpower for the efficient utilization of the domestic available resources. This study can be useful material for evaluating the appropriateness of the Korea's participation in the international collaborative development of the Gen IV, and can be valuably utilized to establish the strategy for the effective conduction of the program. The executive plan of the research and development which was produced in this study will be used to the basic materials for the establishing the guiding direction and the strategic conduction of the program when the research and development is launched in the future.

Gen IV Materials Handbook Functionalities and Operation (2B) Handbook Version 2.0

International Nuclear Information System (INIS)

Ren, Weiju

2011-01-01

This document is prepared for navigation and operation of the Gen IV Materials Handbook, with architecture description and new user access initiation instructions. Development rationale and history of the Handbook is summarized. The major development aspects, architecture, and design principles of the Handbook are briefly introduced to provide an overview of its past evolution and future prospects. Detailed instructions are given with examples for navigating the constructed Handbook components and using the main functionalities. Procedures are provided in a step-by-step fashion for Data Upload Managers to upload reports and data files, as well as for new users to initiate Handbook access.

Gen IV Materials Handbook Functionalities and Operation (4A) Handbook Version 4.0

Energy Technology Data Exchange (ETDEWEB)

Ren, Weiju [ORNL

2013-09-01

This document is prepared for navigation and operation of the Gen IV Materials Handbook, with architecture description and new user access initiation instructions. Development rationale and history of the Handbook is summarized. The major development aspects, architecture, and design principles of the Handbook are briefly introduced to provide an overview of its past evolution and future prospects. Detailed instructions are given with examples for navigating the constructed Handbook components and using the main functionalities. Procedures are provided in a step-by-step fashion for Data Upload Managers to upload reports and data files, as well as for new users to initiate Handbook access.

Gen IV Materials Handbook Functionalities and Operation (2B) Handbook Version 2.0

Energy Technology Data Exchange (ETDEWEB)

Ren, Weiju [ORNL

2011-08-01

This document is prepared for navigation and operation of the Gen IV Materials Handbook, with architecture description and new user access initiation instructions. Development rationale and history of the Handbook is summarized. The major development aspects, architecture, and design principles of the Handbook are briefly introduced to provide an overview of its past evolution and future prospects. Detailed instructions are given with examples for navigating the constructed Handbook components and using the main functionalities. Procedures are provided in a step-by-step fashion for Data Upload Managers to upload reports and data files, as well as for new users to initiate Handbook access.

Key Factors for the Linkage Strategy between R and D and Commercialization for Gen-ΙV

International Nuclear Information System (INIS)

Lee, Kyoungmi; Hong, Jung Suk

2013-01-01

The Fukushima nuclear disaster has leaded to enhance the safety and the cost-effectiveness of technology for the future so that advanced countries such as United Sates and France have concerned about a next generation nuclear power plant, Gen-IV(Generation-IV Reactor). Considering various characteristics of nuclear R and D, it is necessary to have more elaborated strategies for the effective development of the next generation of nuclear technology. In this study, we suggest 5 key factors for the successful commercialization of Gen-IV by analyzing the distinct characteristics of nuclear R and D with Gen-IV and CSF(Critical Success Factor)s of several cases in these field and conducting the FGI(Focus Group Interview). Considering these results, we could find and suggest some important points for further strategy for Gen-IV. That is, following five key factors for the linkage improvement between R and D and commercialization of Gen-IV should be considered: the participation of nuclear power plant operators from the beginning, the establishment of consistent and comprehensive plan/roadmap/detailed strategy, the technology development based on global energy issues and international cooperation, the stable and clear funding plans for long-term projects, the cooperation of relative ministries. Gen-IV system is getting a positive response in that it accompanies long-term R and D plans in Korea. We think that the standard of Gen-IV would lead the next generation of nuclear industry if the proper strategy for the cooperation between the private sector and the regulation from the beginning. Moreover, we expect that this study will facilitate its development process from R and D to commercialization

Key Factors for the Linkage Strategy between R and D and Commercialization for Gen-ΙV

Energy Technology Data Exchange (ETDEWEB)

Lee, Kyoungmi; Hong, Jung Suk [Korean Institute of S and T Evaluation and Planning, Seoul (Korea, Republic of)

2013-05-15

The Fukushima nuclear disaster has leaded to enhance the safety and the cost-effectiveness of technology for the future so that advanced countries such as United Sates and France have concerned about a next generation nuclear power plant, Gen-IV(Generation-IV Reactor). Considering various characteristics of nuclear R and D, it is necessary to have more elaborated strategies for the effective development of the next generation of nuclear technology. In this study, we suggest 5 key factors for the successful commercialization of Gen-IV by analyzing the distinct characteristics of nuclear R and D with Gen-IV and CSF(Critical Success Factor)s of several cases in these field and conducting the FGI(Focus Group Interview). Considering these results, we could find and suggest some important points for further strategy for Gen-IV. That is, following five key factors for the linkage improvement between R and D and commercialization of Gen-IV should be considered: the participation of nuclear power plant operators from the beginning, the establishment of consistent and comprehensive plan/roadmap/detailed strategy, the technology development based on global energy issues and international cooperation, the stable and clear funding plans for long-term projects, the cooperation of relative ministries. Gen-IV system is getting a positive response in that it accompanies long-term R and D plans in Korea. We think that the standard of Gen-IV would lead the next generation of nuclear industry if the proper strategy for the cooperation between the private sector and the regulation from the beginning. Moreover, we expect that this study will facilitate its development process from R and D to commercialization.

Environmental sensitivity studies for Gen-IV roadmap DUPIC scenario

International Nuclear Information System (INIS)

Jeong, Chang Joon

2004-03-01

The environmental effect of the DUPIC (Direct Use of Spent PWR Fuel in CANDU Reactors) fuel cycle, which is considered as one of the partial recycle scenario in Gen-IV roadmap, has been analyzed by using the dynamic analysis method. Through the parametric calculations for the DUPIC fuel cycle deployment time and the fraction of the DUPIC reactors, the environmental effects of the fuel cycle for important parameters such as the amount of spent fuel and the combined amounts of plutonium and minor actinides were estimated and compared to those of the once-through LWR fuel cycle. The results of the sensitivity calculations showed that an early deployment of the DUPIC fuel cycle with a high DUPIC reactor fraction can reduce the accumulation of spent fuel by up to 40%. More important is the associated reduction in the combined amount of plutonium and minor actinides, which may reduce the key repository parameter (long term decay heat). Therefore it is expected that favorable environmental effects will be the outcome of the implementation of the DUPIC fuel cycle

A Study on planning of promotion for international collaborative development of Generation IV Nuclear Energy Systems

International Nuclear Information System (INIS)

Hee, Chang Moon; Yang, M. S.; Ha, J. J.

2006-06-01

Korea has participated in the international collaboration programs for the development of future nuclear energy systems driven by the countries holding advanced nuclear technology and Korea and U. S. have cooperated in the INERI. This study is mainly at developing the plan for participation in the collaborative development of the Gen IV, searching the participation strategy for INERI and the INPRO, and the international cooperation in these programs. Contents and scope of the study for successful achievement are as follows; - Investigation and analysis of international and domestic trends related to advanced nuclear technologies - Development of the plan for collaborative development of the Gen IV and conducting the international cooperation activities - Support for the activities related to I-NERI between Korea and U. S. and conducting the international cooperation - International cooperation activities for the INPRO This study can be useful for planning the research plan and setting up of the strategy of integrating the results of the international collaboration and the domestic R and D results by combining the Gen IV and the domestic R and D in the field of future nuclear technology. Furthermore, this study can contribute to establishing the effective foundation and broadening the cooperation activities not only with the advanced countries for acquisition of the advanced technologies but also with the developing countries for the export of the domestic nuclear energy systems

Environmental sensitivity studies for Gen-IV roadmap fast reactor scenario

International Nuclear Information System (INIS)

Jeong, Chang Joon

2004-03-01

The environmental effect of the self-sufficient fast reactor scenario, which is considered as one of the full fissile plutonium and transuranic recycle scenario in Gen-IV roadmap, has been analyzed by using the dynamic analysis method. Through the parametric calculations for the fast reactor deployment time and capacity, the environmental effects of the fuel cycle for important parameters such as the amount of spent fuel and the combined amounts of plutonium and minor actinides were estimated and compared to those of the once-through LWR fuel cycle. The results of the sensitivity calculations showed that an early deployment of the fast reactor with a high capacity can reduce the accumulation of spent fuel by up to 37%. Furthermore, the recycling of plutonium and minor actinides can reduce the key repository parameter (long term decay heat). Therefore the favorable environmental effects can be expected with the implementation of the symbiotic fast reactor scenario

The ENEN-III project: Technical Training on the Concepts and Design of GEN IV nuclear reactors

International Nuclear Information System (INIS)

Berkvens, T.; Renault, C.; Alonso, M.; Salomaa, R.; Schönfelder, C.

2013-01-01

Some conclusions: • Not enough training courses to cover the LO’s: – Especially GEN IV; – Many introductory courses, little specific courses; – Reach out to other partners for more courses. • Skills and Attitudes: – Much more difficult to train/measure; – To be treated in a separate project. • Use of Learning Outcomes must be promoted; • Involvement of human resources necessary for the successful implementation of the schemes: – End of project workshop

Overview of materials R and D for fusion and Gen-4

Energy Technology Data Exchange (ETDEWEB)

Kohyama, A. [Kyoto Univ., lnstitute of Advanced Energy (Japan); Tavassoli, F.; Carre, F.; Billot, P. [CEA Saclay, 91 - Gif sur Yvette (France); Zinide, S. [Oak Ridge National Laboratory, Materials Science and Technology Div., AK TN (United States)

2007-07-01

Full text of publication follows: In view of the growing need for energy, the risk of exhaustion of fossil fuel and the problem of global warming, the nuclear energy is receiving added attention as a realistic and viable advanced solution. International collaborations on Generation IV (Gen-IV) fission reactors and on ITER and DEMO fusion reactors are developing. This is particularly the case in the sector of materials, where they hold the key to success of these systems. The international community has recognized and planned its materials R and D work for Fusion and Gen-IV reactors with the following considerations: 1- The time allotted to materials R and D is short and may not allow development of totally new materials. 2- Activities required, to cover existing materials variations and service conditions necessary for reactor design, are very time consuming. 3- The work to be done must build upon the existing knowledge of materials and avoid duplications. Although ITER for fusion and Generation four International Forum (GIF) for Gen-IV are important international collaborative programs, they are insufficient to meet all the national energy policies of the participating countries. This paper provides an overview of the materials R and D carried out for fusion and Gen-IV reactors at international and national levels. Materials programs discussed include both cross-cutting and reactor specific actions, where major tasks can be defined as: + Cross-cutting materials tasks: - materials for high temperature service; - materials with neutron damage tolerance; - materials behavior analysis and modeling; - high temperature design methodology. + Reactor specific materials tasks: - very high temperature alloys; - carbon, high temperature ceramics and their composites; - materials compatibilities. Starting with a brief introduction of materials R and D strategies, ITER and Broader Approach (BA), overall activities for fusion and GIF for Gen-IV will be reviewed. Domestic

Overview of nuclear safety activities performed by JRC-IE on Gen IV fast reactor concepts

Energy Technology Data Exchange (ETDEWEB)

Tsige-Tamirat, H.; Ammirabile, L.; D' Agata, E.; Fuetterer, M.; Ranguelova, V. [European Commission, Joint Research Centre, Institute for Energy, Westerduinweg 3, 1755LE Petten (Netherlands)

2010-07-01

The European Strategic Energy Technology (SET) Plan recognizes the need to develop new energy technologies, in order to reduce greenhouse gas emissions and secure energy supply in Europe. Besides renewable energy and improved energy efficiency, a new generation of nuclear power plants and innovative nuclear power applications can play a significant role to achieve this goal. The JRC Institute for Energy 'Safety of Future Nuclear Reactors' (SFNR) Unit is engaged in experimental research, numerical simulation and modelling, scientific, feasibility and engineering studies on innovative nuclear reactor systems. This also represents a significant EURATOM contribution to the Generation IV International Forum. Its activities deal with, among others, the performance assessment of innovative fuels and materials, development of new reactor core concepts and safety solutions, and knowledge management and preservation. Special attention is given to fast reactor concepts, namely the sodium (SFR) and lead (LFR) cooled reactors. Recognizing the maturity of the SFR technology, the European Sustainable Nuclear Energy Technology Platform (SNETP) considers a prototype SFR to be built as a next-step towards the deployment of a first-of-a-kind Gen IV SFR. This paper gives an overview of current research preformed at JRC-IE with emphasis on the work performed in the Collaborative Project on European Sodium Fast Reactor (CP-ESFR) within the European Commission's Seventh Framework Program. (authors)

Overview of nuclear safety activities performed by JRC-IE on Gen IV fast reactor concepts

International Nuclear Information System (INIS)

Tsige-Tamirat, H.; Ammirabile, L.; D'Agata, E.; Fuetterer, M.; Ranguelova, V.

2010-01-01

The European Strategic Energy Technology (SET) Plan recognizes the need to develop new energy technologies, in order to reduce greenhouse gas emissions and secure energy supply in Europe. Besides renewable energy and improved energy efficiency, a new generation of nuclear power plants and innovative nuclear power applications can play a significant role to achieve this goal. The JRC Institute for Energy 'Safety of Future Nuclear Reactors' (SFNR) Unit is engaged in experimental research, numerical simulation and modelling, scientific, feasibility and engineering studies on innovative nuclear reactor systems. This also represents a significant EURATOM contribution to the Generation IV International Forum. Its activities deal with, among others, the performance assessment of innovative fuels and materials, development of new reactor core concepts and safety solutions, and knowledge management and preservation. Special attention is given to fast reactor concepts, namely the sodium (SFR) and lead (LFR) cooled reactors. Recognizing the maturity of the SFR technology, the European Sustainable Nuclear Energy Technology Platform (SNETP) considers a prototype SFR to be built as a next-step towards the deployment of a first-of-a-kind Gen IV SFR. This paper gives an overview of current research preformed at JRC-IE with emphasis on the work performed in the Collaborative Project on European Sodium Fast Reactor (CP-ESFR) within the European Commission's Seventh Framework Program. (authors)

Generation IV nuclear reactors: Current status and future prospects

International Nuclear Information System (INIS)

Locatelli, Giorgio; Mancini, Mauro; Todeschini, Nicola

2013-01-01

Generation IV nuclear power plants (GEN IV NPPs) are supposed to become, in many countries, an important source of base load power in the middle–long term (2030–2050). Nowadays there are many designs of these NPPs but for political, strategic and economic reasons only few of them will be deployed. International literature proposes many papers and reports dealing with GEN IV NPPs, but there is an evident difference in the types and structures of the information and a general unbiased overview is missing. This paper fills the gap, presenting the state-of-the-art for GEN IV NPPs technologies (VHTR, SFR, SCWR, GFR, LFR and MSR) providing a comprehensive literature review of the different designs, discussing the major R and D challenges and comparing them with other advanced technologies available for the middle- and long-term energy market. The result of this research shows that the possible applications for GEN IV technologies are wider than current NPPs. The economics of some GEN IV NPPs is similar to actual NPPs but the “carbon cost” for fossil-fired power plants would increase the relative valuation. However, GEN IV NPPs still require substantial R and D effort, preventing short-term commercial adoption. - Highlights: • Generation IV reactors are the middle–long term technology for nuclear energy. • This paper provides an overview and a taxonomy for the designs under consideration. • R and D efforts are in the material, heat exchangers, power conversion unit and fuel. • The life cycle costs are competitive with other innovative technologies. • The hydrogen economy will foster the development of Generation IV reactors

Nordic Nuclear Materials Forum for Generation IV Reactors

Energy Technology Data Exchange (ETDEWEB)

Anghel, C. (Studsvik Nuclear AB, Nykoeping (Sweden)); Penttilae, S. (Technical Research Centre of Finland, VTT (Finland))

2010-03-15

A network for material issues for Generation IV nuclear power has been initiated within the Nordic countries. The objectives of the Generation IV Nordic Nuclear Materials Forum (NOMAGE4) are to put the basis of a sustainable forum for Gen IV issues, especially focussing on fuels, cladding, structural materials and coolant interaction. Other issues include reactor physics, dynamics and diagnostics, core and fuel design. The present report summarizes the work performed during the year 2009. The efforts made include identification of organisations involved in Gen IV issues in the Nordic countries, update of the forum website, http://www.studsvik.se/GenerationIV, and investigation of capabilities for research within the area of Gen IV. Within the NOMAGE4 project a seminar on Generation IV Nuclear Energy Systems has been organized during 15-16th of October 2009. The aim of the seminar was to provide a forum for exchange of information, discussion on future research needs and networking of experts on Generation IV reactor concepts. As an outcome of the NOMAGE4, a few collaboration project proposals have been prepared/planned in 2009. The network was welcomed by the European Commission and was mentioned as an exemplary network with representatives from industries, universities, power companies and research institutes. NOMAGE4 has been invited to participate to the 'European Energy Research Alliance, EERA, workshop for nuclear structural materials' http://www.eera-set.eu/index.php?index=41 as external observers. Future plans include a new Nordic application for continuation of NOMAGE4 network. (author)

Nordic Nuclear Materials Forum for Generation IV Reactors

International Nuclear Information System (INIS)

Anghel, C.; Penttilae, S.

2010-03-01

A network for material issues for Generation IV nuclear power has been initiated within the Nordic countries. The objectives of the Generation IV Nordic Nuclear Materials Forum (NOMAGE4) are to put the basis of a sustainable forum for Gen IV issues, especially focussing on fuels, cladding, structural materials and coolant interaction. Other issues include reactor physics, dynamics and diagnostics, core and fuel design. The present report summarizes the work performed during the year 2009. The efforts made include identification of organisations involved in Gen IV issues in the Nordic countries, update of the forum website, http://www.studsvik.se/GenerationIV, and investigation of capabilities for research within the area of Gen IV. Within the NOMAGE4 project a seminar on Generation IV Nuclear Energy Systems has been organized during 15-16th of October 2009. The aim of the seminar was to provide a forum for exchange of information, discussion on future research needs and networking of experts on Generation IV reactor concepts. As an outcome of the NOMAGE4, a few collaboration project proposals have been prepared/planned in 2009. The network was welcomed by the European Commission and was mentioned as an exemplary network with representatives from industries, universities, power companies and research institutes. NOMAGE4 has been invited to participate to the 'European Energy Research Alliance, EERA, workshop for nuclear structural materials' http://www.eera-set.eu/index.php?index=41 as external observers. Future plans include a new Nordic application for continuation of NOMAGE4 network. (author)

The Atalante facility at CEA/Marcoule: towards Gen IV systems fuel cycle

Energy Technology Data Exchange (ETDEWEB)

Bordier, Gilles; Warin, Dominique; Masson, Michel [CEA/Marcoule Direction, BP 17171 - 30207 - Bagnols-sur-Ceze Cedex (France)

2008-07-01

The Atalante facility is a complete set of 18 hot labs and 9 shielded cells devoted to the research and development on fuel cycle. The activities correspond to 4 major sectors of nuclear research: -) to support the operation of actual reprocessing plants with the aim of adapting the head of the process to the increase of the spend fuel burn-up and to different types of new burnt fuels to be reprocessed (including MOX, USi or UMo fuels); -) to develop the COEX{sup TM} process that jointly manages uranium and plutonium from the dissolution of spent fuel to the production of UPuO{sub 2} powder and the fabrication of MOX fuel pellets; -) to prepare the recycling of minor actinides (MA) by partitioning or by grouped actinide extraction, and by MA bearing fuel fabrication; -) to study the long term behavior of high level waste conditioning matrices and especially self irradiation and leaching of vitrified waste. The first hot lab of Atalante was operated in 1992, the process shielded cell (CBP) in 2003 and the last LN1 lab in 2005, while at the same time a large scale demonstration test on the DIAMEX-SANEX MA partitioning process was performed. Now some new challenges involve further necessary evolutions of the facility. Some are related to safety assessment and operating flexibility; the major evolutions will come from new scientific goals and research programs. Furthermore, minor actinides materials irradiation tests in fast reactors will be prepared in the framework of a large international cooperation (GACID program) and need the production of significant amounts of MA bearing mixed U-Pu oxide compounds in new hot labs and shielded cells equipment. The major new research tools are presented and we highlight how Atalante is a unique facility which brings a real opportunity to reinforce the European and international scientific cooperation in order to prepare the next Gen IV fuel cycle. (authors)

The Atalante facility at CEA/Marcoule: towards Gen IV systems fuel cycle

International Nuclear Information System (INIS)

Bordier, Gilles; Warin, Dominique; Masson, Michel

2008-01-01

The Atalante facility is a complete set of 18 hot labs and 9 shielded cells devoted to the research and development on fuel cycle. The activities correspond to 4 major sectors of nuclear research: -) to support the operation of actual reprocessing plants with the aim of adapting the head of the process to the increase of the spend fuel burn-up and to different types of new burnt fuels to be reprocessed (including MOX, USi or UMo fuels); -) to develop the COEX TM process that jointly manages uranium and plutonium from the dissolution of spent fuel to the production of UPuO 2 powder and the fabrication of MOX fuel pellets; -) to prepare the recycling of minor actinides (MA) by partitioning or by grouped actinide extraction, and by MA bearing fuel fabrication; -) to study the long term behavior of high level waste conditioning matrices and especially self irradiation and leaching of vitrified waste. The first hot lab of Atalante was operated in 1992, the process shielded cell (CBP) in 2003 and the last LN1 lab in 2005, while at the same time a large scale demonstration test on the DIAMEX-SANEX MA partitioning process was performed. Now some new challenges involve further necessary evolutions of the facility. Some are related to safety assessment and operating flexibility; the major evolutions will come from new scientific goals and research programs. Furthermore, minor actinides materials irradiation tests in fast reactors will be prepared in the framework of a large international cooperation (GACID program) and need the production of significant amounts of MA bearing mixed U-Pu oxide compounds in new hot labs and shielded cells equipment. The major new research tools are presented and we highlight how Atalante is a unique facility which brings a real opportunity to reinforce the European and international scientific cooperation in order to prepare the next Gen IV fuel cycle. (authors)

Unprotected Accident Analyses of the 1200MWe GEN-IV Sodium-Cooled Fast Reactor Using the SSC-K Code

International Nuclear Information System (INIS)

Kwon, Young Min; Lee, Kwi Lim; Ha, Kwi Seok; Jeong, Hae Yong; Chang, Won Pyo; Seok, Su Dong; Lee, Yong Bum

2010-02-01

A conceptual design of an advanced breakeven sodium-cooled fast reactor (G4SFR) has recently been developed by KAERI under the national nuclear R and D plan. The G4SFR is a 1,200MWe metal-fueled pool-type sodium-cooled fast reactor adopting advanced safety design features. The G4SFR development plan focuses on particular technology development efforts to effectively meet the goals of the Generation-IV (GEN-IV) nuclear system such as efficient utilization of resources, economic competitiveness, a high standard of safety, and enhanced proliferation resistance. To enhance the safety of G4SFR, advanced design features of metal-fueled core, simple and large sodium-inventory primary heat transport system, and passive safety decay heat removal system are included in the reactor design. To evaluate potential safety characteristics of such advanced design features, the plant responses and safety margins were investigated using the system transient code SSC-K for three unprotected accidents of UTOP, ULOF, and ULOHS. It was shown that the G4SFR design has inherent and passive safety characteristics and is accommodating the selected ATWS events. The inherent safety mechanism of the reactor design makes the core shutdown with sufficient margin and passive removal of decay heat with matching the core power to heat sink by passive self-regulation. The self-regulation of power without scram is mainly due to the inherent negative reactivity feedback in conjunction with the large thermal inertia of the primary heat transport system and the passive decay heat removal. Such favorable inherent and passive safety behaviors of G4SFR are expected to virtually exclude the probability of severe accidents with potential for core damage

Policy-induced market introduction of Generation IV reactor systems

International Nuclear Information System (INIS)

Heek, Aliki Irina van; Roelofs, Ferry

2011-01-01

Almost 10 years ago the U.S. Department of Energy (DOE) started the Generation IV Initiative (GenIV) with 9 other national governments with a positive ground attitude towards nuclear energy. Some of these Generation IV systems, like the fast reactors, are nearing the demonstration stage. The question on how their market introduction will be implemented becomes increasingly urgent. One main topic for future reactor technologies is the treatment of radioactive waste products. Technological solutions to this issue are being developed. One possible process is the transformation of long-living radioactive nuclides into short living ones; a process known as transmutation, which can be done in a nuclear reactor only. Various Generation IV reactor concepts are suitable for this process, and of these systems most experience has been gained with the sodium-cooled fast reactor (SFR). However, both these first generation SFR plants and their Generation IV successors are designed as electricity generating plants, and therefore supposed to be commercially viable in the electricity markets. Various studies indicate that the generation costs of a combined LWR-(S)FR nuclear generating park (LWR: light water reactor) will be higher than that of an LWR-only park. To investigate the effects of the deployment of the different reactors and fuel cycles on the waste produced, resources used and costs incurred as a function of time, a dynamic fuel cycle assessment is performed. This study will focus on the waste impact of the introduction of a fraction of fast reactors in the European nuclear reactor park with a cost increase as described in the previous paragraph. The nuclear fuel cycle scenario code DANESS is used for this, as well as the nuclear park model of the EU-27 used for the previous study. (orig.)

Gen IV International Forum - GIF, 2010 Annual Report

International Nuclear Information System (INIS)

Anon.

2011-01-01

The Generation IV International Forum (GIF), created in 2000 to foster international collaboration at a detailed level of actual R and D, is a cooperative international endeavor, organized to develop the research necessary to test the feasibility and performance capabilities of fourth generation nuclear systems, with the goal of making such systems deployable in large numbers around 2030. Since its beginning, GIF members stated the following goals for the fourth generation of nuclear power plants when compared to previous generations: a) improve sustainability (including effective fuel utilization and minimization of waste); b) improve economics (competitiveness with respect to other energy sources); c) improve safety and reliability (e.g. no need for offsite emergency response); and d) improve proliferation resistance and physical protection. After an in-depth analysis of the different available concepts, whatever their level of development, the Forum selected six concepts as the most promising, and decided to focus R and D on these systems: - the very-high-temperature reactor (VHTR); - the sodium-cooled fast reactor (SFR); - the supercritical-water-cooled reactor (SCWR); - the gas-cooled fast reactor (GFR); - the lead-cooled fast reactor (LFR); - the molten salt reactor (MSR). Active members of the GIF are Canada, Euratom, France, Japan, People's Republic of China, Republic of Korea, Republic of South Africa, Russian Federation, Switzerland and the United States. Altogether, they represent around 90% of the world installed nuclear capacity for producing electricity, and all key technology holders. The forum is led by the policy group, where all members are represented, and currently chaired by Japan since December 2009, assisted by vice-chairs from France and United States. The year 2010 has seen some important achievements and decisions regarding these six systems. For example, two sodium-cooled fast reactors (re)started this year: Monju in Japan restarted after

Safer Systems: A NextGen Aviation Safety Strategic Goal

Science.gov (United States)

Darr, Stephen T.; Ricks, Wendell R.; Lemos, Katherine A.

2008-01-01

The Joint Planning and Development Office (JPDO), is charged by Congress with developing the concepts and plans for the Next Generation Air Transportation System (NextGen). The National Aviation Safety Strategic Plan (NASSP), developed by the Safety Working Group of the JPDO, focuses on establishing the goals, objectives, and strategies needed to realize the safety objectives of the NextGen Integrated Plan. The three goal areas of the NASSP are Safer Practices, Safer Systems, and Safer Worldwide. Safer Practices emphasizes an integrated, systematic approach to safety risk management through implementation of formalized Safety Management Systems (SMS) that incorporate safety data analysis processes, and the enhancement of methods for ensuring safety is an inherent characteristic of NextGen. Safer Systems emphasizes implementation of safety-enhancing technologies, which will improve safety for human-centered interfaces and enhance the safety of airborne and ground-based systems. Safer Worldwide encourages coordinating the adoption of the safer practices and safer systems technologies, policies and procedures worldwide, such that the maximum level of safety is achieved across air transportation system boundaries. This paper introduces the NASSP and its development, and focuses on the Safer Systems elements of the NASSP, which incorporates three objectives for NextGen systems: 1) provide risk reducing system interfaces, 2) provide safety enhancements for airborne systems, and 3) provide safety enhancements for ground-based systems. The goal of this paper is to expose avionics and air traffic management system developers to NASSP objectives and Safer Systems strategies.

Development of Basic Key Technologies for Gen IV SFR Safety Evaluation

International Nuclear Information System (INIS)

Jeong, Hae Yong; Kwon, Young Min; Kim, Tae Woon; Park, Soo Yong; Suk, Soo Dong; Lee, Kwi Lim; Lee, Yong Bum; Chang, Won Pyo; Ha, Kwi Seok; Hahn, Sang Hoon

2010-07-01

Safety issues and design requirements on control rod worth were identified through the evaluation of safety design characteristics and the preliminary safety evaluation. This results will be taken into account for the conceptual design studies of the demonstration reactor in the next stage. The Level-1 Pasa has been performed and a quantitative Cdf value was produced for the selected design from the several candidates. The inherent safety characteristics of the selected design were evaluated through the DBE and ATWS analyses. A surrogate material for Tru has been selected which is applicable to the study of liquidus/solidus temperature test for the metallic fuel containing Tru. A methodology for the regression analysis with surrogate material has been developed and valuable data on metal fuel liquidus/solidus temperature have been measured. A simple mechanistic model describing a bending of subassemblies has been formulated based on the foreign test data and existing models. Its applicability has been evaluated for the Phenix design. New criteria of the core damage for the SFR PSA were identified. The list of initiating events, system response event tree, and core response event tree, which constitute a PSA methodology for an SFR, have been introduced. By developing the SFR PIRT, phenomenological model features, which have to be satisfied in a safety code, were defined and the PIRT results were applied to the design of the PDRC test facility. Bases for a safety evaluation methodology for the SFR DBEs have been also prepared. A draft version of the topical report on the code for local fault analysis has been completed. Since 2007, the MARS-LMR code has been developed and assessments for model validation with the test data from EBR-II and Phenix reactor have been continued. The code has been applied to the evaluation of passive safety of a conceptual design of Gen IV SFR

Corrosion of structural materials for Generation IV systems

International Nuclear Information System (INIS)

Balbaud-Celerier, F.; Cabet, C.; Courouau, J.L.; Martinelli, L.; Arnoux, P.

2009-01-01

The Generation IV International Forum aims at developing future generation nuclear energy systems. Six systems have been selected for further consideration: sodium-cooled fast reactor (SFR), gas-cooled fast reactor (GFR), lead-cooled fast reactor (LFR), molten salt reactor (MSR), supercritical water-cooled reactor (SCWR) and very high temperature reactor (VHTR). CEA, in the frame of a national program, of EC projects and of the GIF, contributes to the structural materials developments and research programs. Particularly, corrosion studies are being performed in the complex environments of the GEN IV systems. As a matter of fact, structural materials encounter very severe conditions regarding corrosion concerns: high temperatures and possibly aggressive chemical environments. Therefore, the multiple environments considered require also a large diversity of materials. On the other hand, the similar levels of working temperatures as well as neutron spectrum imply also similar families of materials for the various systems. In this paper, status of the research performed in CEA on the corrosion behavior of the structural material in the different environments is presented. The materials studied are either metallic materials as austenitic (or Y, La, Ce doped) and ferrito-martensitic steels, Ni base alloys, ODS steels, or ceramics and composites. In all the environments studied, the scientific approach is identical, the objective being in all cases the understanding of the corrosion processes to establish recommendations on the chemistry control of the coolant and to predict the long term behavior of the materials by the development of corrosion models. (author)

Development of Basic Key Technologies for Gen IV SFR

International Nuclear Information System (INIS)

Han, Do Hee; Kim, Young In; Won, Byung Chool

2008-11-01

Technical specifications such as power capacity, type of core, clad alloy, clad barrier material, number of loops, type of SG tube have been evaluated and a optimal design concept has been identified to satisfy the technology goals of Generation IV nuclear systems. The concept for breakeven design is featured by the heat capacity of 1,200 MWe, enrichment-separated core, 2-loop, double-walled SG tube, and a long-life sensor system for in-service inspection

Advanced Computational Materials Science: Application to Fusion and Generation IV Fission Reactors (Workshop Report)

Energy Technology Data Exchange (ETDEWEB)

Stoller, RE

2004-07-15

The ''Workshop on Advanced Computational Materials Science: Application to Fusion and Generation IV Fission Reactors'' was convened to determine the degree to which an increased effort in modeling and simulation could help bridge the gap between the data that is needed to support the implementation of these advanced nuclear technologies and the data that can be obtained in available experimental facilities. The need to develop materials capable of performing in the severe operating environments expected in fusion and fission (Generation IV) reactors represents a significant challenge in materials science. There is a range of potential Gen-IV fission reactor design concepts and each concept has its own unique demands. Improved economic performance is a major goal of the Gen-IV designs. As a result, most designs call for significantly higher operating temperatures than the current generation of LWRs to obtain higher thermal efficiency. In many cases, the desired operating temperatures rule out the use of the structural alloys employed today. The very high operating temperature (up to 1000 C) associated with the NGNP is a prime example of an attractive new system that will require the development of new structural materials. Fusion power plants represent an even greater challenge to structural materials development and application. The operating temperatures, neutron exposure levels and thermo-mechanical stresses are comparable to or greater than those for proposed Gen-IV fission reactors. In addition, the transmutation products created in the structural materials by the high energy neutrons produced in the DT plasma can profoundly influence the microstructural evolution and mechanical behavior of these materials. Although the workshop addressed issues relevant to both Gen-IV and fusion reactor materials, much of the discussion focused on fusion; the same focus is reflected in this report. Most of the physical models and computational methods

TidGen Power System Commercialization Project

Energy Technology Data Exchange (ETDEWEB)

Sauer, Christopher R. [President & CEO; McEntee, Jarlath [VP Engineering & CTO

2013-12-30

ORPC Maine, LLC, a wholly-owned subsidiary of Ocean Renewable Power Company, LLC (collectively ORPC), submits this Final Technical Report for the TidGen® Power System Commercialization Project (Project), partially funded by the U.S. Department of Energy (DE-EE0003647). The Project was built and operated in compliance with the Federal Energy Regulatory Commission (FERC) pilot project license (P-12711) and other permits and approvals needed for the Project. This report documents the methodologies, activities and results of the various phases of the Project, including design, engineering, procurement, assembly, installation, operation, licensing, environmental monitoring, retrieval, maintenance and repair. The Project represents a significant achievement for the renewable energy portfolio of the U.S. in general, and for the U.S. marine hydrokinetic (MHK) industry in particular. The stated Project goal was to advance, demonstrate and accelerate deployment and commercialization of ORPC’s tidal-current based hydrokinetic power generation system, including the energy extraction and conversion technology, associated power electronics, and interconnection equipment capable of reliably delivering electricity to the domestic power grid. ORPC achieved this goal by designing, building and operating the TidGen® Power System in 2012 and becoming the first federally licensed hydrokinetic tidal energy project to deliver electricity to a power grid under a power purchase agreement in North America. Located in Cobscook Bay between Eastport and Lubec, Maine, the TidGen® Power System was connected to the Bangor Hydro Electric utility grid at an on-shore station in North Lubec on September 13, 2012. ORPC obtained a FERC pilot project license for the Project on February 12, 2012 and the first Maine Department of Environmental Protection General Permit issued for a tidal energy project on January 31, 2012. In addition, ORPC entered into a 20-year agreement with Bangor Hydro Electric

Enhanced radiation resistance through interface modification of nano-structured steels for Gen IV in-core applications

International Nuclear Information System (INIS)

Jang, Jinsung; Kang, Suk Hoon; Kim, Min Chul

2013-06-01

This project is to increase radiation tolerance of candidate alloys for Gen IV core component through the optimization of grain size and grain boundary characteristics. The focus is on nanocrystalline metal alloys with a fcc crystal structure. The long-term goal is to design and develop bulk nanostructured austenitic steels with enhanced void swelling resistance and substantial ductility, and to enhance their creep resistance at elevated temperatures via grain boundary engineering. An austenitic stainless steel, HT-UPS (high temperature ultra-fine precipitates strengthened) was developed at ORNL, and is expected to show enhanced void swelling resistance through the trapping of point defects at nanometer-sized carbides. Reducing the grain size and increasing the fraction-induced point defects (due to the increased sink area of the grain boundaries), to make bubble nucleation at the boundaries less likely (by reducing the fraction of high-energy boundaries), and to improve the strength and ductility under radiation by producing a higher density of nanometer sized carbides on the boundaries

Environmental Information for the U.S. Next Generation Air Transportation System (NextGen)

Science.gov (United States)

Murray, J.; Miner, C.; Pace, D.; Minnis, P.; Mecikalski, J.; Feltz, W.; Johnson, D.; Iskendarian, H.; Haynes, J.

2009-09-01

It is estimated that weather is responsible for approximately 70% of all air traffic delays and cancellations in the United States. Annually, this produces an overall economic loss of nearly 40B. The FAA and NASA have determined that weather impacts and other environmental constraints on the U.S. National Airspace System (NAS) will increase to the point of system unsustainability unless the NAS is radically transformed. A Next Generation Air Transportation System (NextGen) is planned to accommodate the anticipated demand for increased system capacity and the super-density operations that this transformation will entail. The heart of the environmental information component that is being developed for NextGen will be a 4-dimensional data cube which will include a single authoritative source comprising probabilistic weather information for NextGen Air Traffic Management (ATM) systems. Aviation weather constraints and safety hazards typically comprise meso-scale, storm-scale and microscale observables that can significantly impact both terminal and enroute aviation operations. With these operational impacts in mind, functional and performance requirements for the NextGen weather system were established which require significant improvements in observation and forecasting capabilities. This will include satellite observations from geostationary and/or polar-orbiting hyperspectral sounders, multi-spectral imagers, lightning mappers, space weather monitors and other environmental observing systems. It will also require improved in situ and remotely sensed observations from ground-based and airborne systems. These observations will be used to better understand and to develop forecasting applications for convective weather, in-flight icing, turbulence, ceilings and visibility, volcanic ash, space weather and the environmental impacts of aviation. Cutting-edge collaborative research efforts and results from NASA, NOAA and the FAA which address these phenomena are summarized

Description of Guyruita gen. nov. and two new species (Ischnocolinae, Theraphosidae Descrição de Guyruita gen. nov. e duas novas espécies (Ischnocolinae, Theraphosidae

Directory of Open Access Journals (Sweden)

José P.L. Guadanucci

2007-12-01

Full Text Available The genus Guyruita gen. nov. and two new species from Brazil are described. Holothele waikoshiemi (Bertani & Araújo, 2005 from Venezuela is transferred here to the new genus. Guyruita gen. nov. differs from the remaining Ischnocolinae by the following features: labium densely occupied by a lot of cuspules (more than 100, intercheliceral intumescence absent, posterior sternal sigilla remote from margin, tarsal claws without teeth, tarsal scopula I-II undivided (tarsus II with a line of sparse setae, which does not divide the scopula, III-IV divided.É descrito o gênero Guyruita gen. nov. e duas espécies novas do Brasil. Holothele waikoshiemi (Bertani & Araújo, 2005 da Venezuela é transferido para o novo gênero. Guyruita gen. nov. difere dos outros Ischnocolinae pelas seguintes caracterísicas: lábio densamente ocupado por muitas cúspides (mais de 100, tumescência interqueliceral ausente, sigilla esternal posterior distante da margem, unhas tarsais sem dentes, escópula tarsal I e II inteiras (tarso II com uma fileira de cerdas esparsas, as quais não dividem a escópula, III e IV divididas.

Conceptual Design on Primary Control Rod Drive Mechanism of a Prototype Gen-IV SFR

International Nuclear Information System (INIS)

Lee, Jae Han; Koo, Gyeong Hoi

2013-01-01

This paper describes the key concept of the drive mechanism, and suggests a required motor power and reducer gears to meet the functional design requirements, and a seismic response analysis of CRDM housing is performed to check its structural integrity. An AC servo motor is selected as a CRA driving power because it uses permanent magnets and is brushless type while DC motor needs a brush and a coil rotates. The control shim motor size is constrained by a housing diameter of 250mm. The driving system has several design requirements. To calculate the motor power, the drive shaft torque is needed. One part of the drive shaft has a lead screw, driving by a ball-nut. The ball screw driver torque (Tr) is calculated by some equations as follow; A servo motor with a nominal power of 100W, a nominal torque of 0.32 N-m (max. 0.48N-m) is selected considering a safety margin. Its diameter is about 50mm. The fast drive-in motor needs a strong power to insert enforcedly the stuck CRA into core within a required time. The motor sizes are calculated by the same procedure. The diameters are in the range of 80mm to 110mm by the insertion time (10 ∼ 24 seconds). The prototype Gen-IV SFR (sodium-cooled Fast Reactor) is of 150MWe capacity. The reactor has six primary control rod assemblies(CRAs). The primary control rod is used for power control, burn-up compensation and reactor shutdown in response to demands from the plant control or protection systems. The control rod drive mechanism (CRDM) consists of the drive motor assembly, the driveline, and its housing. The driveline consists of three concentric members of a drive shaft, a tension tube, and a position indicator rod, and it connects the drive motor assembly to the CRA. Main issue is that these many driving parts shall be enclosed within a limited housing diameter because the available pitch of CRDMs is limited by 300mm

Conceptual Design on Primary Control Rod Drive Mechanism of a Prototype Gen-IV SFR

Energy Technology Data Exchange (ETDEWEB)

Lee, Jae Han; Koo, Gyeong Hoi [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

2013-10-15

This paper describes the key concept of the drive mechanism, and suggests a required motor power and reducer gears to meet the functional design requirements, and a seismic response analysis of CRDM housing is performed to check its structural integrity. An AC servo motor is selected as a CRA driving power because it uses permanent magnets and is brushless type while DC motor needs a brush and a coil rotates. The control shim motor size is constrained by a housing diameter of 250mm. The driving system has several design requirements. To calculate the motor power, the drive shaft torque is needed. One part of the drive shaft has a lead screw, driving by a ball-nut. The ball screw driver torque (Tr) is calculated by some equations as follow; A servo motor with a nominal power of 100W, a nominal torque of 0.32 N-m (max. 0.48N-m) is selected considering a safety margin. Its diameter is about 50mm. The fast drive-in motor needs a strong power to insert enforcedly the stuck CRA into core within a required time. The motor sizes are calculated by the same procedure. The diameters are in the range of 80mm to 110mm by the insertion time (10 ∼ 24 seconds). The prototype Gen-IV SFR (sodium-cooled Fast Reactor) is of 150MWe capacity. The reactor has six primary control rod assemblies(CRAs). The primary control rod is used for power control, burn-up compensation and reactor shutdown in response to demands from the plant control or protection systems. The control rod drive mechanism (CRDM) consists of the drive motor assembly, the driveline, and its housing. The driveline consists of three concentric members of a drive shaft, a tension tube, and a position indicator rod, and it connects the drive motor assembly to the CRA. Main issue is that these many driving parts shall be enclosed within a limited housing diameter because the available pitch of CRDMs is limited by 300mm.

Nordic forum for generation IV reactors, status and activities in 2012

International Nuclear Information System (INIS)

Van Nieuwenhove, R.; Lauritzen, B.; Nonboel, E.

2012-12-01

The Nordic-Gen4 (continuation from NOMAGE4) seminar was this year hosted by DTU Nutech at Risoe, Denmark. The seminar was well attended (49 participants from 12 countries). The presentations covered many aspects in Gen-IV reactor research and gave a good overview of the activities within this field at the various institutes and universities. The present report contains book of abstracts. The individual Power Point presentations are indexed in INIS and may be found at http://nordic-gen4.org/seminars/nordic-gen4-riso-2012-2/ (LN)

Nordic forum for generation IV reactors, status and activities in 2012

Energy Technology Data Exchange (ETDEWEB)

Van Nieuwenhove, R. [Institutt for Energiteknikk, OECD Halden Reactor Project, Kjeller (Norway); Lauritzen, B.; Nonboel, E. [Technical Univ. of Denmark. DTU Nutech, Roskilde (Denmark)

2012-12-15

The Nordic-Gen4 (continuation from NOMAGE4) seminar was this year hosted by DTU Nutech at Risoe, Denmark. The seminar was well attended (49 participants from 12 countries). The presentations covered many aspects in Gen-IV reactor research and gave a good overview of the activities within this field at the various institutes and universities. The present report contains book of abstracts. The individual Power Point presentations are indexed in INIS and may be found at http://nordic-gen4.org/seminars/nordic-gen4-riso-2012-2/ (LN)

A Qualitative Assessment of Diversion Scenarios for a GEN IV Example Sodium Fast Reactor Using the GEN IV PR and PP Methodology

Energy Technology Data Exchange (ETDEWEB)

Zentner, M.D.; Coles, G.A. [PNNL, P.O. Box 999, 902 Battelle Boulvard, Richland, WA 99336 (United States); Therios, I.U. [Argonne National Lab. - ANL (United States)

2009-06-15

An experts working group was created in 2002 by The Generation IV International Forum for the purpose of developing an internationally accepted methodology for assessing the proliferation resistance of a nuclear energy system (NES) and its individual elements. A two year case study was performed by the working group using this methodology to assess the proliferation resistance of a hypothetical NES called the Example Sodium Fast Reactor (ESFR). This work demonstrates how the PR and PP methodology can be used to provide important information to designers at various levels of details, including pre-conceptual design stage. The study analyzes the response of the ESFR entire nuclear energy system to different proliferation and theft strategies. The challenges considered comprise concealed diversion, concealed misuse and abrogation strategies. This paper describes the work done in performing a qualitative assessment of potential concealed diversion scenarios from the ESFR, and includes an evaluation of the potential effect of changes in the conversion ratio on diversion strategies. (authors)

New Materials for NGNP/Gen IV

International Nuclear Information System (INIS)

Swindeman, Robert W.; Marriott, Douglas L.

2009-01-01

The bounding conditions were briefly summarized for the Next Generation Nuclear Plant (NGNP) that is the leading candidate in the Department of Energy Generation IV reactor program. Metallic materials essential to the successful development and proof of concept for the NGNP were identified. The literature bearing on the materials technology for high-temperature gas-cooled reactors was reviewed with emphasis on the needs identified for the NGNP. Several materials were identified for a more thorough study of their databases and behavioral features relative to the requirements ASME Boiler and Pressure Vessel Code, Section III, Division 1, Subsection NH.

Current status of NPP generation IV

International Nuclear Information System (INIS)

Yohanes Dwi Anggoro; Dharu Dewi; Nurlaila; Arief Tris Yuliyanto

2013-01-01

Today development of nuclear technology has reached the stage of research and development of Generation IV nuclear power plants (advanced reactor systems) which is an innovative development from the previous generation of nuclear power plants. There are six types of power generation IV reactors, namely: Very High Temperature Reactor (VHTR), Sodium-cooled Fast Reactor (SFR), Gas-cooled Fast Reactor (GFR), Lead-cooled Fast Reactor (LFR), Molten Salt Reactor (MSR), and Super Critical Water-cooled Reactor (SCWR). The purpose of this study is to know the development of Generation IV nuclear power plants that have been done by the thirteen countries that are members of the Gen IV International Forum (GIF). The method used is review study and refers to various studies related to the current status of research and development of generation IV nuclear power. The result of this study showed that the systems and technology on Generation IV nuclear power plants offer significant advances in sustainability, safety and reliability, economics, and proliferation resistance and physical protection. In addition, based on the research and development experience is estimated that: SFR can be used optimally in 2015, VHTR in 2020, while NPP types GFR, LFR, MSR, and SCWR in 2025. Utilization of NPP generation IV said to be optimal if fulfill the goal of NPP generation IV, such as: capable to generate energy sustainability and promote long-term availability of nuclear fuel, minimize nuclear waste and reduce the long term stewardship burden, has an advantage in the field of safety and reliability compared to the previous generation of NPP and VHTR technology have a good prospects in Indonesia. (author)

Summary of Structural Concept Development and High Temperature Structural Integrity Evaluation Technology for a Gen-IV SFR

Energy Technology Data Exchange (ETDEWEB)

Lee, Jae Han; Joo, Young Sang; Lee, Hyeong Yeon (and others)

2008-04-15

The economic improvement is a hot issue as one of Gen IV nuclear plant goals. It requires many researches and development works to meet the goal by securing the same level of plant safety. One of the key research items is the increase of the plant capacity with the minimum number of components and loops. Through the successful conceptual design experience for the KALIMER-600, the structural design study for a 1200MWe large capacity of sodium-cooled fast reactor has been performed to achieve the above plant size effects. The component number and reactor structural sizing were determined based on the core and fluid system design information. Several researches were performed to reduce the construction cost of NSSS in structural point of view, for example, a simplified component arrangement, concept proposals of integrated components, a high temperature LBB application technology, and an innovative in-service inspection (ISI) tool, and a computer program development of the ASME-NH design procedure of the class 1 structure and component under high temperature over 500 .deg. C. The IHTS piping arrangement was also proposed to minimize the length through the properly locating the SG and pump by 126m. Further studies of these concepts are required to confirm on the fabricability and the structural integrity for the operating and design loads. The proposed concepts will be optimized to a unified conceptual design through several trade-off studies.

Fast reactor development and worldwide cooperation in Generation-IV International Forum

International Nuclear Information System (INIS)

Sagayama, Yutaka

2013-01-01

Objectives of Gen-IV systems development: Goals: Four challenging technology goals have been defined to be applied to innovative nuclear reactor concepts in the 21st century: 1) Safety and Reliability (safe and reliable operation, no offsite emergency response); 2) Sustainability (effective fuel utilization, minimization of nuclear waste); 3) Proliferation Resistance & Physical Protection (to assure unattractive and the least desirable route for diversion or theft of weapons-usable materials, and provide increased physical protection against acts of terrorism); 4) Economic Competitiveness (life-cycle cost advantage over other energy resources). Phase: Each Generation-IV reactor system is one of three stages. 1) Viability Phase; 2) Performance Phase; 3) Demonstration Phase. Target: Commercial Deployment is expected around 2030s or beyond

Complexity analysis of the Next Gen Air Traffic Management System: trajectory based operations.

Science.gov (United States)

Lyons, Rhonda

2012-01-01

According to Federal Aviation Administration traffic predictions currently our Air Traffic Management (ATM) system is operating at 150 percent capacity; forecasting that within the next two decades, the traffic with increase to a staggering 250 percent [17]. This will require a major redesign of our system. Today's ATM system is complex. It is designed to safely, economically, and efficiently provide air traffic services through the cost-effective provision of facilities and seamless services in collaboration with multiple agents however, contrary the vision, the system is loosely integrated and is suffering tremendously from antiquated equipment and saturated airways. The new Next Generation (Next Gen) ATM system is designed to transform the current system into an agile, robust and responsive set of operations that are designed to safely manage the growing needs of the projected increasingly complex, diverse set of air transportation system users and massive projected worldwide traffic rates. This new revolutionary technology-centric system is dynamically complex and is much more sophisticated than it's soon to be predecessor. ATM system failures could yield large scale catastrophic consequences as it is a safety critical system. This work will attempt to describe complexity and the complex nature of the NextGen ATM system and Trajectory Based Operational. Complex human factors interactions within Next Gen will be analyzed using a proposed dual experimental approach designed to identify hazards, gaps and elicit emergent hazards that would not be visible if conducted in isolation. Suggestions will be made along with a proposal for future human factors research in the TBO safety critical Next Gen environment.

Mechanical Design Concept of Fuel Assembly for Prototype GEN-IV Sodium-cooled Fast Reactor

International Nuclear Information System (INIS)

Yoon, K. H.; Lee, C. B.

2014-01-01

The prototype GEN-IV sodium-cooled fast reactor (PGSFR) is an advanced fast reactor plant design that utilizes compact modular pool-type reactors sized to enable factory fabrication and an affordable prototype test for design certification at minimum cost and risk. The design concepts of the fuel assembly (FA) were introduced for a PGSFR. Unlike that for the pressurized water reactor, there is a neutron shielding concept in the FA and recycling metal fuel. The PGSFR core is a heterogeneous, uranium-10% zirconium (U-10Zr) metal alloy fuel design with 112 assemblies: 52 inner core fuel assemblies, 60 outer core fuel assemblies, 6 primary control assemblies, 3 secondary control assemblies, 90 reflector assemblies and 102 B4C shield assemblies. This configuration is shown in Fig. 1. The core is designed to produce 150 MWe with an average temperature rise of 155 .deg. C. The inlet temperature is 390 .deg. C and the bulk outlet temperature is 545 .deg. C. The core height is 900 mm and the gas plenum length is 1,250 mm. A mechanical design of a fuel assembly for a PGSFR was established. The mechanical design concepts are well realized in the design. In addition to this, the analytical and experimental works will be carries out for verifying the design soundness

Mechanical Design Concept of Fuel Assembly for Prototype GEN-IV Sodium-cooled Fast Reactor

Energy Technology Data Exchange (ETDEWEB)

Yoon, K. H.; Lee, C. B. [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

2014-10-15

The prototype GEN-IV sodium-cooled fast reactor (PGSFR) is an advanced fast reactor plant design that utilizes compact modular pool-type reactors sized to enable factory fabrication and an affordable prototype test for design certification at minimum cost and risk. The design concepts of the fuel assembly (FA) were introduced for a PGSFR. Unlike that for the pressurized water reactor, there is a neutron shielding concept in the FA and recycling metal fuel. The PGSFR core is a heterogeneous, uranium-10% zirconium (U-10Zr) metal alloy fuel design with 112 assemblies: 52 inner core fuel assemblies, 60 outer core fuel assemblies, 6 primary control assemblies, 3 secondary control assemblies, 90 reflector assemblies and 102 B4C shield assemblies. This configuration is shown in Fig. 1. The core is designed to produce 150 MWe with an average temperature rise of 155 .deg. C. The inlet temperature is 390 .deg. C and the bulk outlet temperature is 545 .deg. C. The core height is 900 mm and the gas plenum length is 1,250 mm. A mechanical design of a fuel assembly for a PGSFR was established. The mechanical design concepts are well realized in the design. In addition to this, the analytical and experimental works will be carries out for verifying the design soundness.

Analysis of a Spanish energy scenario with Generation IV nuclear reactors

International Nuclear Information System (INIS)

Ochoa, Raquel; Jimenez, Gonzalo; Perez-Martin, Sara

2013-01-01

Highlights: • Spanish energy scenario for the hypothetical deployment of Gen-IV SFR reactors. • Availability of national resources is assessed, considering SFR’s breeding. • An assessment of the impact of transmuting MA on the final repository. • SERPENT code with own pre- and post-processing tools were employed. • The employed SFR core design is based on the specifications of the CP-ESFR. - Abstract: The advantages of fast-spectrum reactors consist not only of an efficient use of fuel through the breeding of fissile material and the use of natural or depleted uranium, but also of the potential reduction of the amount of actinides such as americium and neptunium contained in the irradiated fuel. The first aspect means a guaranteed future nuclear fuel supply. The second fact is key for high-level radioactive waste management, because these elements are the main responsible for the radioactivity of the irradiated fuel in the long term. The present study aims to analyze the hypothetical deployment of a Gen-IV Sodium Fast Reactor (SFR) fleet in Spain. A nuclear fleet of fast reactors would enable a fuel cycle strategy different than the open cycle, currently adopted by most of the countries with nuclear power. A transition from the current Gen-II to Gen-IV fleet is envisaged through an intermediate deployment of Gen-III reactors. Fuel reprocessing from the Gen-II and Gen-III Light Water Reactors (LWR) has been considered. In the so-called advanced fuel cycle, the reprocessed fuel used to produce energy will breed new fissile fuel and transmute minor actinides at the same time. A reference case scenario has been postulated and further sensitivity studies have been performed to analyze the impact of the different parameters on the required reactor fleet. The potential capability of Spain to supply the required fleet for the reference scenario using national resources has been verified. Finally, some consequences on irradiated final fuel inventory are assessed

Basis for the safety approach for design and assessment of Generation IV nuclear systems

International Nuclear Information System (INIS)

Fiorini, G.L.; Leahy, T.

2009-01-01

The primary objective of the RSWG is the implementation of a harmonized approach on long-term safety, and to address risk and regulatory issues in development of the next generation of nuclear systems. To this end, the group is proposing safety goals and evaluation methodology applicable for the design and assessment of future systems. The paper resumes the content of the first RSWG report which provides insights for the safety approach and assists the GIF Systems Steering Committee as well as the GIF Experts Group and the GIF Policy Group for the definition of the most adequate safety related Gen IV R and D. The document is also an essential contributor to help identifying the needed supportive crosscut R and D effort (i.e. applicable to all the innovative nuclear technologies). Although the report presents a number of thoughts and recommendations, it really represents only the start of the efforts for the RSWG. (author)

Typing of 48 autosomal SNPs and amelogenin with GenPlex SNP genotyping system in forensic genetics

DEFF Research Database (Denmark)

Tomas Mas, Carmen; Stangegaard, Michael; Børsting, Claus

2008-01-01

, Somalia and Greenland were investigated with GenPlex using a Biomek 3000 (Beckman Coulter) robot. The results were compared to results obtained with an ISO 17025 accredited SNP typing assay based on single base extension (SBE). With the GenPlex SNP genotyping system, full SNP profiles were obtained in 97.......6% of the investigations. Perfect concordance was obtained in duplicate investigations and the SNP genotypes obtained with the GenPlex system were concordant with those of the accredited SBE based SNP typing system except for one result in rs901398 in one of 286 individuals most likely due to a mutation 6 bp downstream...

Progress reports for Gen IV sodium fast reactor activities FY 2007

International Nuclear Information System (INIS)

Cahalan, J. E.; Tentner, A. M.

2007-01-01

for prevention of progression into severe accident conditions (prevention of core melting) or for mitigation of severe accident consequences (mitigation of the impact of core melting to protect public health and safety). Because design measures for severe accident prevention and mitigation are beyond the normal design basis, established regulatory guidelines and codes do not provide explicit identification of the design performance requirements for severe accident accommodation. The treatment of severe accidents is one of the key issues of R and D plans for the Gen IV systems in general, and for the Sodium Fast Reactor (SFR) in particular. Despite the lack of an unambiguous definition of safety approach applicable for severe accidents, there is an emerging consensus on the need for their consideration for the design. The US SFR program and Argonne National Laboratory (ANL) in particular have actively studied the potential scenarios and consequences of Hypothetical Core Disruptive Accidents (HCDA) for SFRs with oxide fuel during the Fast Flux Test Facility (FFTF) and Clinch River Breeder Reactor Plant (CRBRP) programs in the 70s and 80s. Later, the focus of the US SFR safety R and D activities shifted to the prevention of all HCDAs through passive safety features of the SFRs with metal fuel in the Integral Fast Reactor (IFR) program, and the study of severe accident consequences was de-emphasized. The goal of this paper is to provide an overview of the current SFR safety approach and the role of severe accidents in Japan and France, in preparation for an expected and more active collaboration in this area between the US, Japan, and France

Uranium enrichment reduction in the Prototype Gen-IV sodium-cooled fast reactor (PGSFR) with PBO reflector

Energy Technology Data Exchange (ETDEWEB)

Hartanto, Donny; Kim, Chi Hyung; Kim, Yong Hee [Dept. of Nuclear and Quantum Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon (Korea, Republic of)

2016-04-15

The Korean Prototype Gen-IV sodium-cooled fast reactor (PGSFR) is supposed to be loaded with a relatively-costly low-enriched U fuel, while its envisaged transuranic fuels are not available for transmutation. In this work, the U-enrichment reduction by improving the neutron economy is pursued to save the fuel cost. To improve the neutron economy of the core, a new reflector material, PbO, has been introduced to replace the conventional HT9 reflector in the current PGSFR core. Two types of PbO reflectors are considered: one is the conventional pin-type and the other one is an inverted configuration. The inverted PbO reflector design is intended to maximize the PbO volume fraction in the reflector assembly. In addition, the core radial configuration is also modified to maximize the performance of the PbO reflector. For the baseline PGSFR core with several reflector options, the U enrichment requirement has been analyzed and the fuel depletion analysis is performed to derive the equilibrium cycle parameters. The linear reactivity model is used to determine the equilibrium cycle performances of the core. Impacts of the new PbO reflectors are characterized in terms of the cycle length, neutron leakage, radial power distribution, and operational fuel cost.

Overview of NASA's Next Generation Air Transportation System (NextGen) Research

Science.gov (United States)

Swenson, Harry N.

2009-01-01

This slide presentation is an overview of the research for the Next Generation Air Transportation System (NextGen). Included is a review of the current air transportation system and the challenges of air transportation research. Also included is a review of the current research highlights and significant accomplishments.

Generation IV Nuclear Energy Systems Construction Cost Reductions through the Use of Virtual Environments - Task 5 Report: Generation IV Reactor Virtual Mockup Proof-of-Principle Study

International Nuclear Information System (INIS)

Timothy Shaw; Anthony Baratta; Vaughn Whisker

2005-01-01

Task 5 report is part of a 3 year DOE NERI-sponsored effort evaluating immersive virtual reality (CAVE) technology for design review, construction planning, and maintenance planning and training for next generation nuclear power plants. Program covers development of full-scale virtual mockups generated from 3D CAD data presented in a CAVE visualization facility. Created a virtual mockup of PBMR reactor cavity and discussed applications of virtual mockup technology to improve Gen IV design review, construction planning, and maintenance planning

Generation IV Nuclear Energy Systems Construction Cost Reductions through the Use of Virtual Environments - Task 5 Report: Generation IV Reactor Virtual Mockup Proof-of-Principle Study

Energy Technology Data Exchange (ETDEWEB)

Timothy Shaw; Anthony Baratta; Vaughn Whisker

2005-02-28

Task 5 report is part of a 3 year DOE NERI-sponsored effort evaluating immersive virtual reality (CAVE) technology for design review, construction planning, and maintenance planning and training for next generation nuclear power plants. Program covers development of full-scale virtual mockups generated from 3D CAD data presented in a CAVE visualization facility. Created a virtual mockup of PBMR reactor cavity and discussed applications of virtual mockup technology to improve Gen IV design review, construction planning, and maintenance planning.

Small angle neutron scattering study of nano sized microstructure in Fe-Cr ODS steels for gen IV in-core applications.

Science.gov (United States)

Han, Young-Soo; Mao, Xiadong; Jang, Jinsung

2013-11-01

The nano-sized microstructures in Fe-Cr oxide dispersion strengthened steel for Gen IV in-core applications were studied using small angle neutron scattering. The oxide dispersion strengthened steel was manufactured through hot isostatic pressing with various chemical compositions and fabrication conditions. Small angle neutron scattering experiments were performed using a 40 m small angle neutron scattering instrument at HANARO. Nano sized microstructures, namely, yttrium oxides and Cr-oxides were quantitatively analyzed by small angle neutron scattering. The yttrium oxides and Cr-oxides were also observed by transmission electron microscopy. The microstructural analysis results from small angle neutron scattering were compared with those obtained by transmission electron microscopy. The effects of the chemical compositions and fabrication conditions on the microstructure were investigated in relation to the quantitative microstructural analysis results obtained by small angle neutron scattering. The volume fraction of Y-oxide increases after fabrication, and this result is considered to be due to the formation of non-stochiometric Y-Ti-oxides.

Identification and Characterization of Key Human Performance Issues and Research in the Next Generation Air Transportation System (NextGen)

Science.gov (United States)

Lee, Paul U.; Sheridan, Tom; Poage, james L.; Martin, Lynne Hazel; Jobe, Kimberly K.

2010-01-01

This report identifies key human-performance-related issues associated with Next Generation Air Transportation System (NextGen) research in the NASA NextGen-Airspace Project. Four Research Focus Areas (RFAs) in the NextGen-Airspace Project - namely Separation Assurance (SA), Airspace Super Density Operations (ASDO), Traffic Flow Management (TFM), and Dynamic Airspace Configuration (DAC) - were examined closely. In the course of the research, it was determined that the identified human performance issues needed to be analyzed in the context of NextGen operations rather than through basic human factors research. The main gaps in human factors research in NextGen were found in the need for accurate identification of key human-systems related issues within the context of specific NextGen concepts and better design of the operational requirements for those concepts. By focusing on human-system related issues for individual concepts, key human performance issues for the four RFAs were identified and described in this report. In addition, mixed equipage airspace with components of two RFAs were characterized to illustrate potential human performance issues that arise from the integration of multiple concepts.

Innovative materials for GEN IV systems and transmutation facilities (cross-cutting research project GETMAT)

International Nuclear Information System (INIS)

Fazio, Concetta; Rieth, Michael; Gomez Briceno, Dolores; Gessi, Alessandro; Henry, Jean; Malerba, Lorenzo

2010-01-01

The objectives of the 'Generation IV and Transmutation Materials' (GETMAT) project is to contribute to the development, qualification and ranking of different types of ODS steels and to qualify Ferritic/Martensitic steels in a wide irradiation condition range. The experimental approach is complemented by the development of physical models with the aim to understand and improve the predictability of the materials performance. The GETMAT consortium is composed of fourteen Research centres, nine Universities and one Utility, from eleven European countries. The R and D tasks address (i) the materials availability, fabricability, weldability and their fundamental mechanical properties, (ii) their compatibility with aggressive coolants and development of corrosion protection methods; (iii) their performance under neutron irradiation, and (iv) starting from model alloys relevant for the two classes of alloys, the development and validation of physical models. The exploitation of results to potential end-users will occur through the 'GETMAT User Group', where exchange of information with the nuclear and steel industries, international (outside Europe) Research Organisations and engineers involved in the design of the new reactors, will occur. The exploitation of results to potential end-users will occur through the G ETMAT User Group , where exchange of information with the nuclear and steel industries, international (outside Europe) Research Organisations and engineers involved in the design of the new reactors, will occur

DETEKSI GEN-GEN PENYANDI FAKTOR VIRULENSI PADA BAKTERI VIBRIO

Directory of Open Access Journals (Sweden)

Ince Ayu Khairani Kadriah

2011-04-01

menggunakan isolat bakteri yang diisolasi dari budidaya udang windu di berbagai daerah di Sulawesi Selatan dan Jawa. Pada penelitian ini digunakan primer spesifik untuk mendeteksi gen-gen virulen toxR gene, hemolysin (vvh gene, dan GyrB gene dengan metode PCR. Dari 35 isolat yang diisolasi, 20 isolat terdeteksi memiliki gen virulensi dan 8 di antaranya memiliki dua gen virulen. Spesies bakteri yang memiliki gen virulen adalah: V.harveyi, V. parahaemolyticus, V. mimicus, dan V. campbelli

Mechanisms Governing the Creep Behavior of High Temperature Alloys for Generation IV Nuclear Energy Systems

Energy Technology Data Exchange (ETDEWEB)

Vasudevan, Vijay [Univ. of Cincinnati, OH (United States); Carroll, Laura [Idaho National Lab. (INL), Idaho Falls, ID (United States); Sham, Sam [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

2015-04-06

This research project, which includes collaborators from INL and ORNL, focuses on the study of alloy 617 and alloy 800H that are candidates for applications as intermediate heat exchangers in GEN IV nuclear reactors, with an emphasis on the effects of grain size, grain boundaries and second phases on the creep properties; the mechanisms of dislocation creep, diffusional creep and cavitation; the onset of tertiary creep; and theoretical modeling for long-term predictions of materials behavior and for high temperature alloy design.

Mechanisms Governing the Creep Behavior of High Temperature Alloys for Generation IV Nuclear Energy Systems

International Nuclear Information System (INIS)

Vasudevan, Vijay; Carroll, Laura; Sham, Sam

2015-01-01

This research project, which includes collaborators from INL and ORNL, focuses on the study of alloy 617 and alloy 800H that are candidates for applications as intermediate heat exchangers in GEN IV nuclear reactors, with an emphasis on the effects of grain size, grain boundaries and second phases on the creep properties; the mechanisms of dislocation creep, diffusional creep and cavitation; the onset of tertiary creep; and theoretical modeling for long-term predictions of materials behavior and for high temperature alloy design.

From AWE-GEN to AWE-GEN-2d: a high spatial and temporal resolution weather generator

Science.gov (United States)

Peleg, Nadav; Fatichi, Simone; Paschalis, Athanasios; Molnar, Peter; Burlando, Paolo

2016-04-01

A new weather generator, AWE-GEN-2d (Advanced WEather GENerator for 2-Dimension grid) is developed following the philosophy of combining physical and stochastic approaches to simulate meteorological variables at high spatial and temporal resolution (e.g. 2 km x 2 km and 5 min for precipitation and cloud cover and 100 m x 100 m and 1 h for other variables variable (temperature, solar radiation, vapor pressure, atmospheric pressure and near-surface wind). The model is suitable to investigate the impacts of climate variability, temporal and spatial resolutions of forcing on hydrological, ecological, agricultural and geomorphological impacts studies. Using appropriate parameterization the model can be used in the context of climate change. Here we present the model technical structure of AWE-GEN-2d, which is a substantial evolution of four preceding models (i) the hourly-point scale Advanced WEather GENerator (AWE-GEN) presented by Fatichi et al. (2011, Adv. Water Resour.) (ii) the Space-Time Realizations of Areal Precipitation (STREAP) model introduced by Paschalis et al. (2013, Water Resour. Res.), (iii) the High-Resolution Synoptically conditioned Weather Generator developed by Peleg and Morin (2014, Water Resour. Res.), and (iv) the Wind-field Interpolation by Non Divergent Schemes presented by Burlando et al. (2007, Boundary-Layer Meteorol.). The AWE-GEN-2d is relatively parsimonious in terms of computational demand and allows generating many stochastic realizations of current and projected climates in an efficient way. An example of model application and testing is presented with reference to a case study in the Wallis region, a complex orography terrain in the Swiss Alps.

Safety assessment for Generation IV nuclear systems

International Nuclear Information System (INIS)

Leahy, T.J.

2012-01-01

The Generation IV International Forum (GIF) Risk and Safety Working Group (RSWG) was created to develop an effective approach for the safety of Generation IV advanced nuclear energy systems. Recent RSWG work has focused on the definition of an integrated safety assessment methodology (ISAM) for evaluating the safety of Generation IV systems. ISAM is an integrated 'tool-kit' consisting of 5 analytical techniques that are available and matched to appropriate stages of Generation IV system concept development: 1) qualitative safety features review - QSR, 2) phenomena identification and ranking table - PIRT, 3) objective provision tree - OPT, 4) deterministic and phenomenological analyses - DPA, and 5) probabilistic safety analysis - PSA. The integrated methodology is intended to yield safety-related insights that help actively drive the evolving design throughout the technology development cycle, potentially resulting in enhanced safety, reduced costs, and shortened development time

Generation IV Nuclear Energy Systems Construction Cost Reductions through the Use of Virtual Environments - Final Report

International Nuclear Information System (INIS)

Timothy Shaw; Anthony Baratta; Vaughn Whisker

2005-01-01

Final report of 3 year DOE NERI-sponsored effort evaluating immersive virtual reality (CAVE) technology for design review, construction planning, and maintenance planning and training for next generation nuclear power plants. Program covers development of full-scale virtual mockups generated from 3D CAD data presented in a CAVE visualization facility. Mockups applied to design review of AP600/1000, Construction planning for AP 600, and AP 1000 maintenance evaluation. Proof of concept study also performed for GenIV PBMR models

Generation IV Nuclear Energy Systems Construction Cost Reductions through the Use of Virtual Environments - Final Report

Energy Technology Data Exchange (ETDEWEB)

Timothy Shaw; Anthony Baratta; Vaughn Whisker

2005-02-28

Final report of 3 year DOE NERI-sponsored effort evaluating immersive virtual reality (CAVE) technology for design review, construction planning, and maintenance planning and training for next generation nuclear power plants. Program covers development of full-scale virtual mockups generated from 3D CAD data presented in a CAVE visualization facility. Mockups applied to design review of AP600/1000, Construction planning for AP 600, and AP 1000 maintenance evaluation. Proof of concept study also performed for GenIV PBMR models.

Report and analysis on 'PR and PP evaluation. Example sodium fast reactor full system case study'

International Nuclear Information System (INIS)

Sagara, Hiroshi; Inoue, Naoko; Kawakubo, Yoko; Watahiki, Masaru

2011-01-01

The Generation IV (GEN IV) Nuclear Energy Systems International Forum (GIF) Proliferation Resistance and Physical Protection Working Group (PRPP WG) was established in December 2002 in order to develop the PR and valuation methodology for GEN IV nuclear energy systems. In the final report of 'PR and PP Evaluation: Example Sodium Fast Reactor (ESFR) Full System Case Study,' issued in October 2009, the demonstration study of PR and PP evaluation with the qualitative approach are summarized using ESFR with four scenario threats. The present paper reviews and analyzes some results of the ESFR case study, and identifies the challenges and direction for the PR and PP evaluation methodology with quantitative approach. (author)

Taxonomic dissection of the genus Micrococcus: Kocuria gen. nov., Nesterenkonia gen. nov., Kytococcus gen. nov., Dermacoccus gen. nov., and Micrococcus Cohn 1872 gen. emend.

Science.gov (United States)

Stackebrandt, E; Koch, C; Gvozdiak, O; Schumann, P

1995-10-01

The results of a phylogenetic and chemotaxonomic analysis of the genus Micrococcus indicated that it is significantly heterogeneous. Except for Micrococcus lylae, no species groups phylogenetically with the type species of the genus, Micrococcus luteus. The other members of the genus form three separate phylogenetic lines which on the basis of chemotaxonomic properties can be assigned to four genera. These genera are the genus Kocuria gen. nov. for Micrococcus roseus, Micrococcus varians, and Micrococcus kristinae, described as Kocuria rosea comb. nov., Kocuria varians comb. nov., and Kocuria kristinae comb. nov., respectively; the genus Nesterenkonia gen. nov. for Micrococcus halobius, described as Nesterenkonia halobia comb. nov.; the genus Nesterenkonia gen. nov. for Micrococcus halobius, described as Nesterenkonia halobia comb. nov.; the genus Dermacoccus gen. nov. for Micrococcus nishinomiyaensis, described as Dermacoccus nishinomiyaensis comb. nov.; and the genus Kytocossus gen. nov. for Micrococcus sedentarius, described as Kytococcus sedentarius comb. nov. M. luteus and M. lylae, which are closely related phylogenetically but differ in some chemotaxonomic properties, are the only species that remain in the genus Micrococcus Cohn 1872. An emended description of the genus Micrococcus is given [corrected].

Generation-IV nuclear reactors, SFR concept

International Nuclear Information System (INIS)

Dufour, P.

2010-01-01

In this presentation author deals with development of sodium-cooled fast reactors and lead-cooled fast reactors. He concluded that: - SFR is a proved concept that has never achieved industrial deployment; - The GEN IV objectives need to reconsider the design of both the core and the reactor design : innovations are being analysed; Future design will benefit from considerable feedback of design, licensing, construction and operation of PX, SPX, etc.

Status of the French R/D program on the severe accident issue to develop Gen IV SFRs - 15373

International Nuclear Information System (INIS)

Serre, F.; Bertrand, F.; Journeau, C.; Suteau, C.; Verwaede, D.; Schmitt, D.; Farges, B.

2015-01-01

The ASTRID reactor (Advanced Sodium Technological Reactor for Industrial Demonstration) is a technological demonstrator designed by the CEA with its industrial partners, with very high levels of requirements. In the ASTRID project, the safety objectives are to prevent core melting, in particular by the development of an innovative core with complementary safety prevention devices, and to enhance the reactor resistance to severe accident by design. To mitigate the consequences of hypothetical core melting situations, specific dispositions or mitigation devices will be added to the core and to the reactor. It is also required to provide a robust safety demonstration (with high level of confidence). Therefore a new approach for severe accident issue has been defined: to the well-known 'lines of defense' method, a 'lines of mitigation' method is added. To meet these ASTRID, or future SFR, requirements, a large R/D program was launched in the Severe Accident domain, with a large number of partners. This paper will present the status of the CEA R/D related to the SFR Severe Accident issue, the collaboration framework (with industrial partners and R/D foreign organizations), and the future R/D plans to support the ASTRID project and possible developments for future Gen IV commercial SFR. (authors)

Optimal trading strategy for GenCo in LMP-based and bilateral ...

African Journals Online (AJOL)

cboonchu

GenCo) ... In Li and Shahidehpour (2005), a game-based bidding strategy for GenCos with ..... With the different demands, dispatched levels of GenCos vary as shown in Table 6. .... optimisation, AI applications to power systems, and power system ...

Enhanced Flight Vision Systems and Synthetic Vision Systems for NextGen Approach and Landing Operations

Science.gov (United States)

Kramer, Lynda J.; Bailey, Randall E.; Ellis, Kyle K. E.; Williams, Steven P.; Arthur, Jarvis J., III; Prinzel, Lawrence J., III; Shelton, Kevin J.

2013-01-01

Synthetic Vision Systems and Enhanced Flight Vision System (SVS/EFVS) technologies have the potential to provide additional margins of safety for aircrew performance and enable operational improvements for low visibility operations in the terminal area environment with equivalent efficiency as visual operations. To meet this potential, research is needed for effective technology development and implementation of regulatory standards and design guidance to support introduction and use of SVS/EFVS advanced cockpit vision technologies in Next Generation Air Transportation System (NextGen) operations. A fixed-base pilot-in-the-loop simulation test was conducted at NASA Langley Research Center that evaluated the use of SVS/EFVS in NextGen low visibility approach and landing operations. Twelve crews flew approach and landing operations in a simulated NextGen Chicago O'Hare environment. Various scenarios tested the potential for using EFVS to conduct approach, landing, and roll-out operations in visibility as low as 1000 feet runway visual range (RVR). Also, SVS was tested to evaluate the potential for lowering decision heights (DH) on certain instrument approach procedures below what can be flown today. Expanding the portion of the visual segment in which EFVS can be used in lieu of natural vision from 100 feet above the touchdown zone elevation to touchdown and rollout in visibilities as low as 1000 feet RVR appears to be viable as touchdown performance was acceptable without any apparent workload penalties. A lower DH of 150 feet and/or possibly reduced visibility minima using SVS appears to be viable when implemented on a Head-Up Display, but the landing data suggests further study for head-down implementations.

Development of basic key technologies for Gen IV SFR

International Nuclear Information System (INIS)

Kim, Yeongil; Kim, Sungoh; Choi, Sukgi

2012-04-01

The advanced concepts, for the breakeven reactor(1,200MWe) and TRU burner(600MWe), were defined to satisfy the technology goals of Generation IV nuclear systems. Based on the advanced design concepts, a conceptual design of the demonstration SFR has been developed using the available licensing technology. The conceptual core design has been developed for the TRU burner in which an initial core is fueled with less than 20wt% enriched U235, and finally transformed to a self-recycled TRU core. The passive decay heat removal circuit ensuring reactor safety even in case of loss of emergency power has been developed and minimization of a reactor vessel and simplification of reactor internals have been conducted in the conceptual design. For development of advanced technologies, control logics for various power levels and the optimal design concept of heat exchanger applicable to supercritical CO 2 Brayton cycle as an energy conversion system was developed. A novel under-sodium waveguide sensor and a prototype under-sodium inspection system have been developed for under-sodium viewing of in-vessel structures submerged in an opaque liquid sodium. The fabrication technology of fuel slugs using the advanced fuel slug casting system was developed, and U-Zr alloy fuel rods were fabricated and examined. And a HT 9 cladding tube was manufactured using the developed cladding tube fabrication technology. For development of basic technologies, the cross section adjustment code ATCROSS and the MATRA-LMR code with HCFs have been developed to reduce core design uncertainties. The SIE ASME-NH computer program to evaluate high temperature structural design for 60 years design life, and the safety analysis code MARS-LMR with thermal-hydraulic and reactivity feedback models have been developed and validated. In addition, the sodium impurity measurement and control technology, the sodium water reaction event propagation model to predict the sodium leak propagation in a steam generator, and

Updated Generation IV Reactors Integrated Materials Technology Program Plan, Revision 2

Energy Technology Data Exchange (ETDEWEB)

Corwin, William R [ORNL; Burchell, Timothy D [ORNL; Halsey, William [Lawrence Livermore National Laboratory (LLNL); Hayner, George [Idaho National Laboratory (INL); Katoh, Yutai [ORNL; Klett, James William [ORNL; McGreevy, Timothy E [ORNL; Nanstad, Randy K [ORNL; Ren, Weiju [ORNL; Snead, Lance Lewis [ORNL; Stoller, Roger E [ORNL; Wilson, Dane F [ORNL

2005-12-01

The Department of Energy's (DOE's) Generation IV Nuclear Energy Systems Program will address the research and development (R&D) necessary to support next-generation nuclear energy systems. Such R&D will be guided by the technology roadmap developed for the Generation IV International Forum (GIF) over two years with the participation of over 100 experts from the GIF countries. The roadmap evaluated over 100 future systems proposed by researchers around the world. The scope of the R&D described in the roadmap covers the six most promising Generation IV systems. The effort ended in December 2002 with the issue of the final Generation IV Technology Roadmap [1.1]. The six most promising systems identified for next generation nuclear energy are described within the roadmap. Two employ a thermal neutron spectrum with coolants and temperatures that enable hydrogen or electricity production with high efficiency (the Supercritical Water Reactor - SCWR and the Very High Temperature Reactor - VHTR). Three employ a fast neutron spectrum to enable more effective management of actinides through recycling of most components in the discharged fuel (the Gas-cooled Fast Reactor - GFR, the Lead-cooled Fast Reactor - LFR, and the Sodium-cooled Fast Reactor - SFR). The Molten Salt Reactor (MSR) employs a circulating liquid fuel mixture that offers considerable flexibility for recycling actinides, and may provide an alternative to accelerator-driven systems. A few major technologies have been recognized by DOE as necessary to enable the deployment of the next generation of advanced nuclear reactors, including the development and qualification of the structural materials needed to ensure their safe and reliable operation. Accordingly, DOE has identified materials as one of the focus areas for Gen IV technology development.

GenBank

OpenAIRE

Benson, Dennis A.; Karsch-Mizrachi, Ilene; Lipman, David J.; Ostell, James; Rapp, Barbara A.; Wheeler, David L.

2002-01-01

The GenBank sequence database incorporates publicly available DNA sequences of more than 105 000 different organisms, primarily through direct submission of sequence data from individual laboratories and large-scale sequencing projects. Most submissions are made using the BankIt (web) or Sequin programs and accession numbers are assigned by GenBank staff upon receipt. Data exchange with the EMBL Data Library and the DNA Data Bank of Japan helps ensure comprehensive worldwide coverage. GenBank...

The I-V Measurement System for Solar Cells Based on MCU

International Nuclear Information System (INIS)

Chen Fengxiang; Ai Yu; Wang Jiafu; Wang Lisheng

2011-01-01

In this paper, an I-V measurement system for solar cells based on Single-chip Microcomputer (MCU) is presented. According to the test principles of solar cells, this measurement system mainly comprises of two parts-data collecting, data processing and displaying. The MCU mainly used as to acquire data, then the collecting results is sent to the computer by serial port. The I-V measurement results of our test system are shown in the human-computer interaction interface based on our hardware circuit. By comparing the test results of our I-V tester and the results of other commercial I-V tester, we found errors for most parameters are less than 5%, which shows our I-V test result is reliable. Because the MCU can be applied in many fields, this I-V measurement system offers a simple prototype for portable I-V tester for solar cells.

The I-V Measurement System for Solar Cells Based on MCU

Energy Technology Data Exchange (ETDEWEB)

Chen Fengxiang; Ai Yu; Wang Jiafu; Wang Lisheng, E-mail: phonixchen79@yahoo.com.cn [Department of physics science and technology, Wuhan University of Technology, Wuhan city, Hubei Province, 430070 (China)

2011-02-01

In this paper, an I-V measurement system for solar cells based on Single-chip Microcomputer (MCU) is presented. According to the test principles of solar cells, this measurement system mainly comprises of two parts-data collecting, data processing and displaying. The MCU mainly used as to acquire data, then the collecting results is sent to the computer by serial port. The I-V measurement results of our test system are shown in the human-computer interaction interface based on our hardware circuit. By comparing the test results of our I-V tester and the results of other commercial I-V tester, we found errors for most parameters are less than 5%, which shows our I-V test result is reliable. Because the MCU can be applied in many fields, this I-V measurement system offers a simple prototype for portable I-V tester for solar cells.

Next Gen One Portal Usability Evaluation

Science.gov (United States)

Cross, E. V., III; Perera, J. S.; Hanson, A. M.; English, K.; Vu, L.; Amonette, W.

2018-01-01

Each exercise device on the International Space Station (ISS) has a unique, customized software system interface with unique layouts / hierarchy, and operational principles that require significant crew training. Furthermore, the software programs are not adaptable and provide no real-time feedback or motivation to enhance the exercise experience and/or prevent injuries. Additionally, the graphical user interfaces (GUI) of these systems present information through multiple layers resulting in difficulty navigating to the desired screens and functions. These limitations of current exercise device GUI's lead to increased crew time spent on initiating, loading, performing exercises, logging data and exiting the system. To address these limitations a Next Generation One Portal (NextGen One Portal) Crew Countermeasure System (CMS) was developed, which utilizes the latest industry guidelines in GUI designs to provide an intuitive ease of use approach (i.e., 80% of the functionality gained within 5-10 minutes of initial use without/limited formal training required). This is accomplished by providing a consistent interface using common software to reduce crew training, increase efficiency & user satisfaction while also reducing development & maintenance costs. Results from the usability evaluations showed the NextGen One Portal UI having greater efficiency, learnability, memorability, usability and overall user experience than the current Advanced Resistive Exercise Device (ARED) UI used by astronauts on ISS. Specifically, the design of the One-Portal UI as an app interface similar to those found on the Apple and Google's App Store, assisted many of the participants in grasping the concepts of the interface with minimum training. Although the NextGen One-Portal UI was shown to be an overall better interface, observations by the test facilitators noted specific exercise tasks appeared to have a significant impact on the NextGen One-Portal UI efficiency. Future updates to

Autosomal SNP typing of forensic samples with the GenPlex(TM) HID System: Results of a collaborative study

DEFF Research Database (Denmark)

Tomas, C.; Axler-DiPerte, G.; Budimlija, Z.M.

2011-01-01

in Europe and 5 in the US) in order to test the robustness and reliability of the GenPlex(TM) HID System on forensic samples. Three samples with partly degraded DNA and 10 samples with low amounts of DNA were analyzed in duplicates using various amounts of DNA. In order to compare the performance of the Gen......Plex(TM) HID System with the most commonly used STR kits, 500 pg of partly degraded DNA from three samples was typed by the laboratories using one or more STR kits. The median SNP typing success rate was 92.3% with 500 pg of partly degraded DNA. Three of the fourteen laboratories counted for more than two...... was the least successful. With the exception of the MiniFiler(TM) kit (AB), GenPlex(TM) HID performed better than five other tested STR kits. When partly degraded DNA was analyzed, GenPlex(TM) HID showed a very low mean mach probability, while all STR kits except MiniFiler(TM) had very limited discriminatory...

GenBank

Data.gov (United States)

U.S. Department of Health & Human Services — GenBank is the NIH genetic sequence database, an annotated collection of all publicly available DNA sequences. GenBank is designed to provide and encourage access...

Economic, energy and GHG emissions performance evaluation of a WhisperGen Mk IV Stirling engine μ-CHP unit in a domestic dwelling

International Nuclear Information System (INIS)

Conroy, G.; Duffy, A.; Ayompe, L.M.

2014-01-01

Highlights: • The performance of a Stirling engine MK IV micro-CHP unit was evaluated in a domestic dwelling in Ireland. • The performance of the micro-CHP was compare to that of a condensing gas boiler. • The micro-CHP unit resulted in an annual cost saving of €180 compared to the condensing gas boiler. • Electricity imported from the grid decreased by 20.8% while CO 2 emissions decreased by 16.1%. • The micro-CHP unit used 2889 kW h of gas more than the condensing gas boiler during one year of operation. - Abstract: This paper presents an assessment of the energy, economic and greenhouse gas emissions performances of a WhisperGen Mk IV Stirling engine μ-CHP unit for use in a conventional house in the Republic of Ireland. The energy performance data used in this study was obtained from a field trial carried out in Belfast, Northern Ireland during the period June 2004–July 2005 by Northern Ireland Electricity and Phoenix Gas working in collaboration with Whispertech UK. A comparative performance analysis between the μ-CHP unit and a condensing gas boiler revealed that the μ-CHP unit resulted in an annual cost saving of €180 with an incremental simple payback period of 13.8 years when compared to a condensing gas boiler. Electricity imported from the grid decreased by 20.8% while CO 2 emissions decreased by 16.1%. The μ-CHP unit used 2889 kW h of gas more than the condensing gas boiler

Review on Korea Participation of Generation IV International Forum (GIF)

International Nuclear Information System (INIS)

Lee, Jewhan; Jeong, Ji-Young; Hahn, Dohee

2015-01-01

Generation IV International Forum (GIF) originates from US proposal of an initiative in 2000. The vision was to leapfrog LWR technology and collaborate with international partners to share R and D on advanced nuclear systems. Nine countries and EU joined the initiative and Gen IV concept was defined via technology goals and legal framework. Two years study with more than 100 experts worldwide has evaluated nearly 100 reactor designs and down selected six most promising concepts. In 2005, the first signatures on Framework Agreement were collected and the first research projects were defined in 2006. Korea is one of the founding members of GIF and actively participating in various areas. In 2013, TD was assigned to Korean expert and Korea is endeavoring to enhance the benefit of participation since this turning point. In this paper, pros and cons of engaging with GIF were briefly introduced and items to maximize the benefit were suggested

Review on Korea Participation of Generation IV International Forum (GIF)

Energy Technology Data Exchange (ETDEWEB)

Lee, Jewhan; Jeong, Ji-Young; Hahn, Dohee [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

2015-05-15

Generation IV International Forum (GIF) originates from US proposal of an initiative in 2000. The vision was to leapfrog LWR technology and collaborate with international partners to share R and D on advanced nuclear systems. Nine countries and EU joined the initiative and Gen IV concept was defined via technology goals and legal framework. Two years study with more than 100 experts worldwide has evaluated nearly 100 reactor designs and down selected six most promising concepts. In 2005, the first signatures on Framework Agreement were collected and the first research projects were defined in 2006. Korea is one of the founding members of GIF and actively participating in various areas. In 2013, TD was assigned to Korean expert and Korea is endeavoring to enhance the benefit of participation since this turning point. In this paper, pros and cons of engaging with GIF were briefly introduced and items to maximize the benefit were suggested.

Gens Fera. The Wild men in the system of border decoration of the Bible of Wenceslas IV

Czech Academy of Sciences Publication Activity Database

Studničková, Milada

2014-01-01

Roč. 62, č. 3 (2014), s. 214-239 ISSN 0049-5123 R&D Projects: GA ČR GA13-39192S Institutional support: RVO:68378033 Keywords : book illumination * Bible of Wenceslas IV Subject RIV: AL - Art, Architecture, Cultural Heritage http://www.umeni-art.cz/admin/fileGet.aspx?v=issue-issue-2267-category-2268-paragraph-2269-pdf&l=cz

An Integrated Safety Assessment Methodology for Generation IV Nuclear Systems

International Nuclear Information System (INIS)

Leahy, Timothy J.

2010-01-01

The Generation IV International Forum (GIF) Risk and Safety Working Group (RSWG) was created to develop an effective approach for the safety of Generation IV advanced nuclear energy systems. Early work of the RSWG focused on defining a safety philosophy founded on lessons learned from current and prior generations of nuclear technologies, and on identifying technology characteristics that may help achieve Generation IV safety goals. More recent RSWG work has focused on the definition of an integrated safety assessment methodology for evaluating the safety of Generation IV systems. The methodology, tentatively called ISAM, is an integrated 'toolkit' consisting of analytical techniques that are available and matched to appropriate stages of Generation IV system concept development. The integrated methodology is intended to yield safety-related insights that help actively drive the evolving design throughout the technology development cycle, potentially resulting in enhanced safety, reduced costs, and shortened development time.

On the Safety and Performance Demonstration Tests of Prototype Gen-IV Sodium-Cooled Fast Reactor and Validation and Verification of Computational Codes

Directory of Open Access Journals (Sweden)

Jong-Bum Kim

2016-10-01

Full Text Available The design of Prototype Gen-IV Sodium-Cooled Fast Reactor (PGSFR has been developed and the validation and verification (V&V activities to demonstrate the system performance and safety are in progress. In this paper, the current status of test activities is described briefly and significant results are discussed. The large-scale sodium thermal-hydraulic test program, Sodium Test Loop for Safety Simulation and Assessment-1 (STELLA-1, produced satisfactory results, which were used for the computer codes V&V, and the performance test results of the model pump in sodium showed good agreement with those in water. The second phase of the STELLA program with the integral effect tests facility, STELLA-2, is in the detailed design stage of the design process. The sodium thermal-hydraulic experiment loop for finned-tube sodium-to-air heat exchanger performance test, the intermediate heat exchanger test facility, and the test facility for the reactor flow distribution are underway. Flow characteristics test in subchannels of a wire-wrapped rod bundle has been carried out for safety analysis in the core and the dynamic characteristic test of upper internal structure has been performed for the seismic analysis model for the PGSFR. The performance tests for control rod assemblies (CRAs have been conducted for control rod drive mechanism driving parts and drop tests of the CRA under scram condition were performed. Finally, three types of inspection sensors under development for the safe operation of the PGSFR were explained with significant results.

On the safety and performance demonstration tests of Prototype Gen-IV Sodium-Cooled Fast Reactor and validation and verification of computational codes

Energy Technology Data Exchange (ETDEWEB)

Kim, Jong Bum; Jeong, Ji Young; Lee, Tae Ho; Kim, Sung Kyun; Euh, Dong Jin; Joo, Hyung Kook [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

2016-10-15

The design of Prototype Gen-IV Sodium-Cooled Fast Reactor (PGSFR) has been developed and the validation and verification (V and V) activities to demonstrate the system performance and safety are in progress. In this paper, the current status of test activities is described briefly and significant results are discussed. The large-scale sodium thermal-hydraulic test program, Sodium Test Loop for Safety Simulation and Assessment-1 (STELLA-1), produced satisfactory results, which were used for the computer codes V and V, and the performance test results of the model pump in sodium showed good agreement with those in water. The second phase of the STELLA program with the integral effect tests facility, STELLA-2, is in the detailed design stage of the design process. The sodium thermal-hydraulic experiment loop for finned-tube sodium-to-air heat exchanger performance test, the intermediate heat exchanger test facility, and the test facility for the reactor flow distribution are underway. Flow characteristics test in subchannels of a wire-wrapped rod bundle has been carried out for safety analysis in the core and the dynamic characteristic test of upper internal structure has been performed for the seismic analysis model for the PGSFR. The performance tests for control rod assemblies (CRAs) have been conducted for control rod drive mechanism driving parts and drop tests of the CRA under scram condition were performed. Finally, three types of inspection sensors under development for the safe operation of the PGSFR were explained with significant results.

On the safety and performance demonstration tests of Prototype Gen-IV Sodium-Cooled Fast Reactor and validation and verification of computational codes

International Nuclear Information System (INIS)

Kim, Jong Bum; Jeong, Ji Young; Lee, Tae Ho; Kim, Sung Kyun; Euh, Dong Jin; Joo, Hyung Kook

2016-01-01

The design of Prototype Gen-IV Sodium-Cooled Fast Reactor (PGSFR) has been developed and the validation and verification (V and V) activities to demonstrate the system performance and safety are in progress. In this paper, the current status of test activities is described briefly and significant results are discussed. The large-scale sodium thermal-hydraulic test program, Sodium Test Loop for Safety Simulation and Assessment-1 (STELLA-1), produced satisfactory results, which were used for the computer codes V and V, and the performance test results of the model pump in sodium showed good agreement with those in water. The second phase of the STELLA program with the integral effect tests facility, STELLA-2, is in the detailed design stage of the design process. The sodium thermal-hydraulic experiment loop for finned-tube sodium-to-air heat exchanger performance test, the intermediate heat exchanger test facility, and the test facility for the reactor flow distribution are underway. Flow characteristics test in subchannels of a wire-wrapped rod bundle has been carried out for safety analysis in the core and the dynamic characteristic test of upper internal structure has been performed for the seismic analysis model for the PGSFR. The performance tests for control rod assemblies (CRAs) have been conducted for control rod drive mechanism driving parts and drop tests of the CRA under scram condition were performed. Finally, three types of inspection sensors under development for the safe operation of the PGSFR were explained with significant results

Basic research in support of innovative fuels design for the Generation IV systems (F-BRIDGE project)

International Nuclear Information System (INIS)

Valot, Carole; Bertolus, Marjorie; Konings, Rudy; Somers, Joe; Groot, Sander de

2010-01-01

F-BRIDGE (Basic Research in support of Innovative Fuels Design for the GEN IV systems) is a 4-year project which started in 2008. It seeks to bridge the gap between basic research and technological applications for generation IV nuclear reactor systems. One of the challenges for the next generation of reactors is to significantly increase the efficiency in designing innovative fuels. The object of the F-BRIDGE project is to complement the empirical approach by a physically-based description of fuel and cladding materials to enable a rationalization of the design process and a better selection of promising fuel systems. Advanced modelling and separate effects experiments are carried out in order to obtain more exact physical descriptions of ceramic fuels and cladding, at relevant scales from the atomic to the macroscopic scale. Research is also focused on assessing and improving 'sphere-pac' fuel, a composite-ceramics concept which has shown promise. The project activities can be broken down into four main areas: (i) Basic research investigations using a multi-scale approach in both experimentation and modelling to enable the generation of missing basic data, the identification of relevant mechanisms and the development of appropriate models; (ii) Transfer between technological issues and basic research by bringing together within the same project materials scientists, engineers and end-users; (iii) Assessment of the drawbacks and benefits of the sphere-pac fuel application to various Generation IV systems; (iv) Education and training to promote research in the field of fuel materials, to ensure the exchange of results and ideas among the participants and to link the project with other related European or international initiatives. The project relies on the complementary expertise of 19 partners: nuclear and non nuclear research organisations, universities, a nuclear engineering company, as well as technology and project management consultancy small and medium

Analysis of Creep Crack Growth Behavior of Alloy 617 for Use in a VHTR System

International Nuclear Information System (INIS)

Kim, Woo-Gon; Kim, Min-Hwan; Park, Jae-Young; Ekaputra, I. M. W.; Kim, Seon-Jin

2015-01-01

Alloy 617 is a major candidate material for the IHX component. The design of the component, which will operate well into the creep range, will require a good understanding of creep crack growth deformation. Efforts are now being undertaken in the Gen-IV program to provide data needed for the design and licensing of the nuclear plants, and with this goal in mind, to meet the needs of the conceptual designers of the VHTR system, 'Gen-IV Materials Handbook' is being established through an international collaboration program of GIF (Gen-IV Forum) countries. To logically obtain the B and q values in the CCGR equation, three methods in terms of LSFM, MVM, and PDM were adopted. The PDM was most useful. Both the B and q coefficients followed a lognormal distribution. Using a lognormal distribution in the PDM, a number of random variables were generated by Monte Carlo Simulation, and the CCGR lines could be successfully predicted from the viewpoint of reliability

An electronic flight bag for NextGen avionics

Science.gov (United States)

Zelazo, D. Eyton

2012-06-01

The introduction of the Next Generation Air Transportation System (NextGen) initiative by the Federal Aviation Administration (FAA) will impose new requirements for cockpit avionics. A similar program is also taking place in Europe by the European Organisation for the Safety of Air Navigation (Eurocontrol) called the Single European Sky Air Traffic Management Research (SESAR) initiative. NextGen will require aircraft to utilize Automatic Dependent Surveillance-Broadcast (ADS-B) in/out technology, requiring substantial changes to existing cockpit display systems. There are two ways that aircraft operators can upgrade their aircraft in order to utilize ADS-B technology. The first is to replace existing primary flight displays with new displays that are ADS-B compatible. The second, less costly approach is to install an advanced Class 3 Electronic Flight Bag (EFB) system. The installation of Class 3 EFBs in the cockpit will allow aircraft operators to utilize ADS-B technology in a lesser amount of time with a decreased cost of implementation and will provide additional benefits to the operator. This paper describes a Class 3 EFB, the NexisTM Flight-Intelligence System, which has been designed to allow users a direct interface with NextGen avionics sensors while additionally providing the pilot with all the necessary information to meet NextGen requirements.

Technology Road-map Update for Generation IV Nuclear Energy Systems

International Nuclear Information System (INIS)

2014-01-01

This Technology Road-map Update provides an assessment of progress made by the Generation IV International Forum (GIF) in the development of the six systems selected when the original Technology Road-map was published in 2002. More importantly, it provides an overview of the major R and D objectives and milestones for the coming decade, aiming to achieve the Generation IV goals of sustainability, safety and reliability, economic competitiveness, proliferation resistance and physical protection. Lessons learnt from the Fukushima Daiichi nuclear power plant accident are taken into account to ensure that Generation IV systems attain the highest levels of safety, with the development of specific safety design criteria that are applicable across the six systems. Accomplishing the ten-year R and D objectives set out in this new Road-map should allow the more advanced Generation IV systems to move towards the demonstration phase. (authors)

Implementation of SAP-IV on a minicomputer disc operating system

International Nuclear Information System (INIS)

Spencer, R.B.; Howard, G.E.

1977-01-01

The objective of the described effort was the implementation of a linear elastic finite element structural analysis program version on a minicomputer operating system while maintaining (as much as possible) the general features of the original program. SAP-IV has been successfully implemented on a minicomputer operating system as one component in a portable vibration testing, data acquisition and processing, parameter identification and design optimization system for field work. The primary features in SAP-IV facilitating conversion and implementation on a minicomputer are: (1) the calculational procedures of SAP-IV are well documented and the subroutine structure easy to follow; (2) SAP-IV is organized in a highly modular fashion; (3) it is versatile with respect to its calculational options; and (4) the element library can be readily expanded. (Auth.)

Estimación de parámetros genéticos para características productivas y reproductivas en los sistemas doble propósito del trópico bajo colombiano

Directory of Open Access Journals (Sweden)

A. P. Galeano

2010-01-01

Full Text Available Con el objetivo de estimar los componentes de varianza, las heredabilidades, repetibilidades y correlaciones genéticas y fenotípicas para la producción de leche por lactancia (PL, el peso al destete (PD, el intervalo entre partos (IEP y el Índice de Vaca (IV, de las hembras bovinas manejadas en los sistemas de producción de doble propósito del trópico bajo colombiano, se analizaron los registros productivos y reproductivos de 1.687 vacas registradas en la Asociación Colombiana de Criadores de Ganado en Doble Propósito (Asodoble, durante el periodo comprendido entre 1998 y 2007. Se empleó un modelo animal mixto que incluyó los efectos fijos del grupo contemporáneo (finca-sexo-época-año, la composición racial, y la duración de la lactancia como covariable; así como los efectos genéticos aleatorios del animal, el medio ambiente permanente y el residual. Las heredabilidades estimadas para IEP (0,04 y PD (0,11 fueron bajas, y moderadas para PL (0,35 e IV (0,24, respectivamente. La repetibilidad estimada para IEP fue baja (0,08, y para PL (0,41 e IV (0,31 moderada; en el caso de PD este valor fue igual a la heredabilidad (0,11. Las correlaciones genéticas y fenotípicas obtenidas entre PL y PD con respecto a IEP fueron positivas, y se determinó una asociación genética negativa entre PL y PD. Los resultados demostraron que el IV es un buen indicador, desde el punto de vista genético, de la eficiencia productiva y reproductiva de los animales manejados en estos sistemas productivos.

GIF (Gen-IV International Forum) Symposium 2009. Proceedings

International Nuclear Information System (INIS)

2009-01-01

The objective of this symposium is to give a well documented state of the art of the initiative and to report and discuss the most significant technical progress and evolution in the different areas during these last ten years. Another significant objective is to provide a forum for an open and hopefully lively discussion of the perspectives, priorities and challenges for the next few years, accounting for a rapidly evolving environment. The symposium has been organized into three sessions that have dealt with the following issues: -) Generation IV International Forum (GIF): 10 years of achievements and the path forward, -) Methodology Overviews and Focus on Applications, -) Very High Temperature Reactor (VHTR), -) Gas-cooled Fast Reactor (GFR), -) Super-Critical Water-cooled Reactor (SCWR), -) Lead-cooled Fast Reactor (LFR), -) Molten Salt Reactor (MSR), -) Sodium-cooled Fast Reactor (SFR), -) International Project on Innovative Nuclear Reactors and Fuel Cycles (INPRO) and its potential synergy with GIF, and -) GIF priority objectives for the next 5 years

78 FR 56263 - HydroGen Corp., QueryObject Systems Corp., Security Intelligence Technologies, Inc., Skins, Inc...

Science.gov (United States)

2013-09-12

... SECURITIES AND EXCHANGE COMMISSION [File No. 500-1] HydroGen Corp., QueryObject Systems Corp., Security Intelligence Technologies, Inc., Skins, Inc., SLM Holdings, Inc., Spring Creek Healthcare Systems... securities of Security Intelligence Technologies, Inc. because it has not filed any periodic reports since...

Multi-criteria methodology to design a sodium-cooled carbide-fueled Gen-IV reactor

International Nuclear Information System (INIS)

Stauff, N.

2011-01-01

Compared with earlier plant designs (Phenix, Super-Phenix, EFR), Gen IV Sodium-cooled Fast Reactor requires improved economics while meeting safety and non-proliferation criteria. Mixed Oxide (U-Pu)O 2 fuels are considered as the reference fuels due to their important and satisfactory feedback experience. However, innovative carbide (U-Pu)C fuels can be considered as serious competitors for a prospective SFR fleet since carbide-fueled SFRs can offer another type of optimization which might overtake on some aspects the oxide fuel technology. The goal of this thesis is to reveal the potentials of carbide by designing an optimum carbide-fueled SFR with competitive features and a naturally safe behavior during transients. For a French nuclear fleet, a 1500 MW(e) break-even core is considered. To do so, a multi-physic approach was developed taking into account neutronics, fuel thermo-mechanics and thermal-hydraulic at a pre-design stage. Simplified modeling with the calculation of global neutronic feedback coefficients and a quasi-static evaluation was developed to estimate the behavior of a core during overpower transients, loss of flow and/or loss of heat removal transients. The breakthrough of this approach is to provide the designer with an overall view of the iterative process, emphasizing the well-suited innovations and the most efficient directions that can improve the SFR design project.This methodology was used to design a core that benefits from the favorable features of carbide fuels. The core developed is a large carbide-fueled SFR with high power density, low fissile inventory, break-even capability and forgiving behaviors during the un-scrammed transients studied that should prevent using expensive mitigate systems. However, the core-peak burnup is unlikely to significantly exceed 100 MWd/kg because of the large swelling of the carbide fuel leading to quick pellet-clad mechanical interaction and the low creep capacity of carbide. Moderate linear power fuel

Algoritmos genéticos locales

OpenAIRE

García-Martínez, Carlos; Lozano, Manuel

2007-01-01

Los Algoritmos Genéticos Locales son procedimientos que iterativamente re nan soluciones dadas. Su diferencia con procedimientos de mejora iterativa clásicos reside en el uso de operadores genéticos para realizar el re namiento. En este estudio presentamos un nuevo Algoritmo Genético Local Binario basado en un Algoritmo Genético Estacionario. Hemos comparado el Algoritmo Genético Local Binario con otros procedimientos de mejora iterativa de la literatura. Los res...

Analysis of criticality using NJOY, AMPX-II and KENO-IV systems

International Nuclear Information System (INIS)

Ferreira, C.R.; Santos, A. dos

1989-01-01

Trough a linking between the nuclear data code systems NJOY and AMPX-II, performed at Divisao de Fisica de Reatores-IPEN, it was made criticality analysis with the KENO-IV in two fast multiplying systems: JEZEBEL and GODIVA. The ENDF/B-IV and JENDL-2 was used throughout the analysis. It was found that the linking between NJOY and AMPX-II systems can be suitable for a benchmark calculation of neutron cross sections. The KENO-IV code cannot be applied in systems where the degree of anisotropic scattering is too high because this computer code treats scattering up to first order. The XSDRNPM results show that the results obtained with ENDF/B-IV are of better quality than those obtained with JENDL-2. (author) [pt

Implementation of SAP-IV on a minicomputer disc operating system

International Nuclear Information System (INIS)

Spencer, R.B.; Howard, G.E.

1977-01-01

The objective of the described effort was the implementation of a linear elastic finite element structural analysis program version on a minicomputer operating system while maintaining (as much as possible) the general features of the original program. SAP-IV has been successfully implemented on a minicomputer operating system as one component in a portable vibration testing, data acquisition and processing, parameter identification and design optimization system for field work. The primary features in SAP-IV facilitating conversion and implementation on a minicomputer are: (1) the calculational procedures of SAP-IV are well documented and the subroutine structure easy to follow; (2) SAP-IV is organized in a highly modular fashion; (3) it is versatile with respect to its calculational options; and (4) the element library can be readily expanded. SAP-IV was installed on a Data General NOVA 32K memory disc operating system which utilizes various input-output peripherals and a single 1.2 megaword disc. The entire theoretical analysis-vibration test-data analysis-parameter identification-model modification system required such additional components as analog/digital converters, computer-driven electro-mechanical vibrators, a maximum of 512 transducers, and special-purpose software for test planning, execution, data processing, and matrix manipulation. The software system capabilities which allowed implementation of SAP-IV on the minicomputer were: (1) the availability of double precision; (2) the ability to use multiple OVERLAYs; (3) the ability to read and write programs from the disc to memory without destroying the programs (SWAP); (4) the ability to CHAIN a series of connected programs into the memory and execute them sequentially; and (5) the ability to utilize random access disc files

GenBank.

OpenAIRE

Benson, D; Lipman, D J; Ostell, J

1993-01-01

The GenBank sequence database has undergone an expansion in data coverage, annotation content and the development of new services for the scientific community. In addition to nucleotide sequences, data from the major protein sequence and structural databases, and from U.S. and European patents is now included in an integrated system. MEDLINE abstracts from published articles describing the sequences provide an important new source of biological annotation for sequence entries. In addition to ...

Hardware and Software Design of FPGA-based PCIe Gen3 interface for APEnet+ network interconnect system

Science.gov (United States)

Ammendola, R.; Biagioni, A.; Frezza, O.; Lo Cicero, F.; Lonardo, A.; Martinelli, M.; Paolucci, P. S.; Pastorelli, E.; Rossetti, D.; Simula, F.; Tosoratto, L.; Vicini, P.

2015-12-01

In the attempt to develop an interconnection architecture optimized for hybrid HPC systems dedicated to scientific computing, we designed APEnet+, a point-to-point, low-latency and high-performance network controller supporting 6 fully bidirectional off-board links over a 3D torus topology. The first release of APEnet+ (named V4) was a board based on a 40 nm Altera FPGA, integrating 6 channels at 34 Gbps of raw bandwidth per direction and a PCIe Gen2 x8 host interface. It has been the first-of-its-kind device to implement an RDMA protocol to directly read/write data from/to Fermi and Kepler NVIDIA GPUs using NVIDIA peer-to-peer and GPUDirect RDMA protocols, obtaining real zero-copy GPU-to-GPU transfers over the network. The latest generation of APEnet+ systems (now named V5) implements a PCIe Gen3 x8 host interface on a 28 nm Altera Stratix V FPGA, with multi-standard fast transceivers (up to 14.4 Gbps) and an increased amount of configurable internal resources and hardware IP cores to support main interconnection standard protocols. Herein we present the APEnet+ V5 architecture, the status of its hardware and its system software design. Both its Linux Device Driver and the low-level libraries have been redeveloped to support the PCIe Gen3 protocol, introducing optimizations and solutions based on hardware/software co-design.

Divergência genética entre genótipos de frangos tipo caipira

Directory of Open Access Journals (Sweden)

R. C. Veloso

2015-10-01

Full Text Available RESUMOObjetivou-se com este trabalho verificar a divergência genética entre sete genótipos de frangos tipo caipira da linhagem Redbro utilizando as características de desempenho por meio de técnicas de análise multivariada. Foram utilizados 840 pintos de um dia, machos, distribuídos em delineamento inteiramente ao acaso, dos seguintes genótipos: Caboclo, Carijó, Colorpak, Gigante Negro, Pesadão Vermelho, Pescoço Pelado e Tricolor. Após a consistência dos dados, foram avaliadas as seguintes variáveis: ganho em peso médio diário, consumo de ração médio diário e conversão alimentar, para os períodos: 1 a 28, 1 a 56, 1 a 70 e 1 a 84 dias de idade; peso corporal ao nascimento, aos 28, 56, 70 e aos 84 dias de idade. O desempenho dos genótipos foi avaliado por meio da análise de variância multivariada e da função discriminante linear de Fisher, usando os testes do maior autovalor de Roy e da união-interseção de Roy para as comparações múltiplas. O estudo da divergência genética foi feito por meio da análise por variáveis canônicas e pelo método de otimização de Tocher. Os genótipos Caboclo e Gigante Negro apresentaram médias canônicas diferentes dos demais genótipos. As duas primeiras variáveis canônicas explicaram 97,41% da variação entre os genótipos. A divergência genética entre os genótipos avaliados permitiu a formação de quatro grupos com os seguintes genótipos: grupo 1 - Colorpak; grupo 2 - Pesadão Vermelho e Pescoço Pelado; grupo 3 - Carijó e Tricolor; e grupo 4 - Caboclo e Gigante Negro.

Generation IV Reactors Integrated Materials Technology Program Plan: Focus on Very High Temperature Reactor Materials

Energy Technology Data Exchange (ETDEWEB)

Corwin, William R [ORNL; Burchell, Timothy D [ORNL; Katoh, Yutai [ORNL; McGreevy, Timothy E [ORNL; Nanstad, Randy K [ORNL; Ren, Weiju [ORNL; Snead, Lance Lewis [ORNL; Wilson, Dane F [ORNL

2008-08-01

Since 2002, the Department of Energy's (DOE's) Generation IV Nuclear Energy Systems (Gen IV) Program has addressed the research and development (R&D) necessary to support next-generation nuclear energy systems. The six most promising systems identified for next-generation nuclear energy are described within this roadmap. Two employ a thermal neutron spectrum with coolants and temperatures that enable hydrogen or electricity production with high efficiency (the Supercritical Water Reactor-SCWR and the Very High Temperature Reactor-VHTR). Three employ a fast neutron spectrum to enable more effective management of actinides through recycling of most components in the discharged fuel (the Gas-cooled Fast Reactor-GFR, the Lead-cooled Fast Reactor-LFR, and the Sodium-cooled Fast Reactor-SFR). The Molten Salt Reactor (MSR) employs a circulating liquid fuel mixture that offers considerable flexibility for recycling actinides and may provide an alternative to accelerator-driven systems. At the inception of DOE's Gen IV program, it was decided to significantly pursue five of the six concepts identified in the Gen IV roadmap to determine which of them was most appropriate to meet the needs of future U.S. nuclear power generation. In particular, evaluation of the highly efficient thermal SCWR and VHTR reactors was initiated primarily for energy production, and evaluation of the three fast reactor concepts, SFR, LFR, and GFR, was begun to assess viability for both energy production and their potential contribution to closing the fuel cycle. Within the Gen IV Program itself, only the VHTR class of reactors was selected for continued development. Hence, this document will address the multiple activities under the Gen IV program that contribute to the development of the VHTR. A few major technologies have been recognized by DOE as necessary to enable the deployment of the next generation of advanced nuclear reactors, including the development and qualification of

NASA System-Level Design, Analysis and Simulation Tools Research on NextGen

Science.gov (United States)

Bardina, Jorge

2011-01-01

A review of the research accomplished in 2009 in the System-Level Design, Analysis and Simulation Tools (SLDAST) of the NASA's Airspace Systems Program is presented. This research thrust focuses on the integrated system-level assessment of component level innovations, concepts and technologies of the Next Generation Air Traffic System (NextGen) under research in the ASP program to enable the development of revolutionary improvements and modernization of the National Airspace System. The review includes the accomplishments on baseline research and the advancements on design studies and system-level assessment, including the cluster analysis as an annualization standard of the air traffic in the U.S. National Airspace, and the ACES-Air MIDAS integration for human-in-the-loop analyzes within the NAS air traffic simulation.

GenBank

OpenAIRE

Benson, Dennis A.; Cavanaugh, Mark; Clark, Karen; Karsch-Mizrachi, Ilene; Lipman, David J.; Ostell, James; Sayers, Eric W.

2012-01-01

GenBank? (http://www.ncbi.nlm.nih.gov) is a comprehensive database that contains publicly available nucleotide sequences for almost 260 000 formally described species. These sequences are obtained primarily through submissions from individual laboratories and batch submissions from large-scale sequencing projects, including whole-genome shotgun (WGS) and environmental sampling projects. Most submissions are made using the web-based BankIt or standalone Sequin programs, and GenBank staff assig...

Bolivian Rhinotragini IV: Paraeclipta gen. nov. (Coleoptera, Cerambycidae, new species and new combinations

Directory of Open Access Journals (Sweden)

Robin O. S. Clarke

2011-01-01

Full Text Available Paraeclipta gen. nov. is described to allocate five new species, and ten transferred from Eclipta Bates, 1873: P. cabrujai sp. nov.; P. clementecruzi sp. nov.; P. melgarae sp. nov.; P. tomhacketti sp. nov.; P. moscosoi sp. nov.; P. bicoloripes (Zajciw, 1965, comb. nov.; P. croceicornis (Gounelle, 1911, comb. nov.; P. flavipes (Melzer, 1922, comb. nov.; P. jejuna (Gounelle, 1911, comb. nov.; P. kawensis (Peñaherrera-Leiva & Tavakilian, 2004, comb. nov.; P. longipennis (Fisher, 1947, comb. nov.; P. rectipennis (Zajciw, 1965, comb. nov.; P. soumourouensis (Tavakilian & Peñaherrera-Leiva, 2003, comb. nov.; P. tenuis (Burmeister, 1865, comb. nov.; and P. unicoloripes (Zajciw, 1965, comb. nov. The Bolivian species are illustrated. A key to their identification and host flower records are provided.

Hardware and Software Design of FPGA-based PCIe Gen3 interface for APEnet+ network interconnect system

International Nuclear Information System (INIS)

Ammendola, R.; Biagioni, A.; Frezza, O.; Cicero, F. Lo; Lonardo, A; Martinelli, M.; Paolucci, P. S.; Pastorelli, E.; Simula, F.; Tosoratto, L.; Vicini, P.; Rossetti, D.

2015-01-01

In the attempt to develop an interconnection architecture optimized for hybrid HPC systems dedicated to scientific computing, we designed APEnet+, a point-to-point, low-latency and high-performance network controller supporting 6 fully bidirectional off-board links over a 3D torus topology.The first release of APEnet+ (named V4) was a board based on a 40 nm Altera FPGA, integrating 6 channels at 34 Gbps of raw bandwidth per direction and a PCIe Gen2 x8 host interface. It has been the first-of-its-kind device to implement an RDMA protocol to directly read/write data from/to Fermi and Kepler NVIDIA GPUs using NVIDIA peer-to-peer and GPUDirect RDMA protocols, obtaining real zero-copy GPU-to-GPU transfers over the network.The latest generation of APEnet+ systems (now named V5) implements a PCIe Gen3 x8 host interface on a 28 nm Altera Stratix V FPGA, with multi-standard fast transceivers (up to 14.4 Gbps) and an increased amount of configurable internal resources and hardware IP cores to support main interconnection standard protocols.Herein we present the APEnet+ V5 architecture, the status of its hardware and its system software design. Both its Linux Device Driver and the low-level libraries have been redeveloped to support the PCIe Gen3 protocol, introducing optimizations and solutions based on hardware/software co-design. (paper)

GenBank

OpenAIRE

Benson, Dennis A.; Karsch-Mizrachi, Ilene; Lipman, David J.; Ostell, James; Sayers, Eric W.

2008-01-01

GenBank? is a comprehensive database that contains publicly available nucleotide sequences for more than 300 000 organisms named at the genus level or lower, obtained primarily through submissions from individual laboratories and batch submissions from large-scale sequencing projects. Most submissions are made using the web-based BankIt or standalone Sequin programs, and accession numbers are assigned by GenBank? staff upon receipt. Daily data exchange with the European Molecular Biology Labo...

Progress in the development of the neutron flux monitoring system of the French GEN-IV SFR: simulations and experimental validations [ANIMMA--2015-IO-392

Energy Technology Data Exchange (ETDEWEB)

Jammes, C.; Filliatre, P.; Izarra, G. de [CEA, DEN, Cadarache, Reactor Studies Department, 13108 Saint-Paul-lez-Durance (France); Elter, Zs. [CEA, DEN, Cadarache, Reactor Studies Department, 13108 Saint-Paul-lez-Durance (France); Chalmers University of Technology, Department of Applied Physics, Division of Nuclear Engineering, SE-412 96 Goeteborg (Sweden); Verma, V. [CEA, DEN, Cadarache, Reactor Studies Department, 13108 Saint-Paul-lez-Durance (France); Uppsala University, Division of Applied Nuclear Physics, Box 516, SE-75120 Uppsala (Sweden); Hamrita, H.; Bakkali, M. [CEA, DRT, LIST, Metrology, Instrumentation and Information Department, Saclay, 91191 Gif-sur-Yvette (France); Chapoutier, N.; Scholer, A.C.; Verrier, D. [AREVA NP, 10 rue Juliette Recamier F-69456 Lyon (France); Hellesen, C.; Jacobsson, S. [Uppsala University, Division of Applied Nuclear Physics, Box 516, SE-75120 Uppsala (Sweden); Pazsit, I. [Chalmers University of Technology, Department of Applied Physics, Division of Nuclear Engineering, SE-412 96 Goeteborg (Sweden); Cantonnet, B.; Nappe, J.C. [PHOTONIS France, Nuclear Instrumentation, 19100 Brive-la-Gaillarde (France); Molinie, P.; Dessante, P.; Hanna, R.; Kirkpatrick, M.; Odic, E. [Supelec, Energy Department, 3 rue Joliot-Curie, 91191 Gif-sur-Yvette (France)

2015-07-01

France has a long experience of about 50 years in designing, building and operating sodium-cooled fast reactors (SFR) such as RAPSODIE, PHENIX and SUPER PHENIX. Fast reactors feature the double capability of reducing nuclear waste and saving nuclear energy resources by burning actinides. Since this reactor type is one of those selected by the Generation IV International Forum, the French government asked, in the year 2006, CEA, namely the French Alternative Energies and Atomic Energy Commission, to lead the development of an innovative GEN-IV nuclear- fission power demonstrator. The major objective is to improve the safety and availability of an SFR. The neutron flux monitoring (NFM) system of any reactor must, in any situation, permit both reactivity control and power level monitoring from startup to full power. It also has to monitor possible changes in neutron flux distribution within the core region in order to prevent any local melting accident. The neutron detectors will have to be installed inside the reactor vessel because locations outside the vessel will suffer from severe disadvantages; radially the neutron shield that is also contained in the reactor vessel will cause unacceptable losses in neutron flux; below the core the presence of a core-catcher prevents from inserting neutron guides; and above the core the distance is too large to obtain decent neutron signals outside the vessel. Another important point is to limit the number of detectors placed in the vessel in order to alleviate their installation into the vessel. In this paper, we show that the architecture of the NFM system will rely on high-temperature fission chambers (HTFC) featuring wide-range flux monitoring capability. The definition of such a system is presented and the justifications of technological options are brought with the use of simulation and experimental results. Firstly, neutron-transport calculations allow us to propose two in-vessel regions, namely the above-core and under

The Columbus Knee System: 4-Year Results of a New Deep Flexion Design Compared to the NexGen Full Flex Implant

Directory of Open Access Journals (Sweden)

D. Goebel

2012-01-01

Full Text Available The Columbus knee system is designed as a standard knee implant to allow high flexion without additional bone resection. Between August, 2004 and March, 2010 we performed 109 total knee arthroplasties of the Columbus knee system in 101 consecutive patients suffering from primary arthrosis of the knee. Mean age was 72.4 years in women and 70.3 years in men. Mean followup was 47.3 months. The 4-year results of a group of patients who received the NexGen Full Flex implant operated by the same surgeon were used for comparison. Mean total knee score was Columbus: 175.6 and NexGen Flex: 183.4; =0.037. Mean operation time was 53 min for Columbus and 66 min for NexGen Flex; 0.05. Radiological assessment showed no signs of loosening for both groups. Therefore, the Columbus knee system can be recommended for flexion angles up to 140∘.

Overview of Generation IV (Gen IV) Reactor Designs - Safety and Radiological Protection Considerations

International Nuclear Information System (INIS)

Baudrand, Olivier; Blanc, Daniel; Ivanov, Evgeny; Bonneville, Herve; Clement, Bernard; Kissane, Martin; Meignen, Renaud; Monhardt, Daniel; Nicaise, Gregory; Bourgois, Thierry; Bruna, Giovanni; Hache, Georges; Repussard, Jacques

2012-01-01

The purpose of this document is to provide an updated overview of specific safety and radiological protection issues for all the reactor concepts adopted by the GIF (Generation IV International Forum), independent of their advantages or disadvantages in terms of resource optimization or long-lived-waste reduction. In particular, this new document attempts to bring out the advantages and disadvantages of each concept in terms of safety, taking into account the Western European Nuclear Regulators' Association (WENRA) statement concerning safety objectives for new nuclear power plants. Using an identical framework for each reactor concept (sodium-cooled fast reactors or SFR, high / very-high temperature helium-cooled reactors of V/HTR, gas-cooled fast reactors or GFR, lead-or lead / bismuth-cooled fast reactors or LFR, molten salt reactors or MSR, and supercritical-water-cooled reactors or SCWR), this summary report provides some general conclusions regarding their safety and radiological protection issues, inspired by WENRA's safety objectives and on the basis of available information. Initial lessons drawn from the events at the Fukushima-Daiichi nuclear power plant in March 2011 have also been taken into account in IRSN's analysis of each reactor concept

Development of Digital Materials Database for Design and Construction of New Power Plants

International Nuclear Information System (INIS)

Ren, Weiju

2008-01-01

To facilitate materials selection, structural design, and future maintenance of the Generation IV nuclear reactor systems, an interactive, internet accessible materials property database, dubbed Gen IV Materials Handbook, has been under development with the support of the United States Department of Energy. The Handbook will provide an authoritative source of information on structural materials needed for the development of various Gen IV nuclear reactor systems along with powerful data analysis and management tools. In this paper, the background, history, framework, major features, contents, and development strategy of the Gen IV Materials Handbook are discussed. Current development status and future plans are also elucidated.

GenBank

OpenAIRE

Benson, Dennis A.; Karsch-Mizrachi, Ilene; Lipman, David J.; Ostell, James; Wheeler, David L.

2006-01-01

GenBank (R) is a comprehensive database that contains publicly available nucleotide sequences for more than 240 000 named organisms, obtained primarily through submissions from individual laboratories and batch submissions from large-scale sequencing projects. Most submissions are made using the web-based BankIt or standalone Sequin programs and accession numbers are assigned by GenBank staff upon receipt. Daily data exchange with the EMBL Data Library in Europe and the DNA Data Bank of Japan...

NOMAGE4 activities 2011. Part I, Nordic Nuclear Materials Forum for Generation IV Reactors: Status and activities in 2011

International Nuclear Information System (INIS)

Van Nieuwenhove, R.

2012-01-01

A network for materials issues has been initiated in 2009 within the Nordic countries. The original objectives of the Generation IV Nordic Nuclear Materials Forum (NOMAGE4) were to form the basis of a sustainable forum for Gen-IV issues, especially focusing on fuels, cladding, structural materials and coolant interaction. Over the last years, other issues such as reactor physics, thermal hydraulics, safety and waste have gained in importance (within the network) and therefore the scope of the forum has been enlarged and a more appropriate and more general name, NORDIC-GEN4, has been chosen for the forum. Further, the interaction with non-Nordic countries (such as The Netherlands (JRC, NRG) and Czech Republic (CVR)) will be increased. Within the NOMAGE4 project, a seminar was organized by IFE-Halden during 31 October - 1 November 2011. The seminar attracted 65 participants from 12 countries. The seminar provided a forum for exchange of information, discussion on future research reactor needs and networking of experts on Generation IV reactor concepts. The participants could also visit the Halden reactor site and the workshop. (Author)

NOMAGE4 activities 2011. Part I, Nordic Nuclear Materials Forum for Generation IV Reactors: Status and activities in 2011

Energy Technology Data Exchange (ETDEWEB)

Van Nieuwenhove, R. (Institutt for Energiteknikk, OECD Halden Reactor Project (Norway))

2012-01-15

A network for materials issues has been initiated in 2009 within the Nordic countries. The original objectives of the Generation IV Nordic Nuclear Materials Forum (NOMAGE4) were to form the basis of a sustainable forum for Gen-IV issues, especially focusing on fuels, cladding, structural materials and coolant interaction. Over the last years, other issues such as reactor physics, thermal hydraulics, safety and waste have gained in importance (within the network) and therefore the scope of the forum has been enlarged and a more appropriate and more general name, NORDIC-GEN4, has been chosen for the forum. Further, the interaction with non-Nordic countries (such as The Netherlands (JRC, NRG) and Czech Republic (CVR)) will be increased. Within the NOMAGE4 project, a seminar was organized by IFE-Halden during 31 October - 1 November 2011. The seminar attracted 65 participants from 12 countries. The seminar provided a forum for exchange of information, discussion on future research reactor needs and networking of experts on Generation IV reactor concepts. The participants could also visit the Halden reactor site and the workshop. (Author)

SALOME PLATFORM and TetGen for Polyhedral Mesh Generation

Energy Technology Data Exchange (ETDEWEB)

Lee, Sang Yong; Park, Chan Eok; Kim, Shin Whan [KEPCO E and C Company, Inc., Daejeon (Korea, Republic of)

2014-05-15

SPACE and CUPID use the unstructured mesh and they also require reliable mesh generation system. The combination of CAD system and mesh generation system is necessary to cope with a large number of cells and the complex fluid system with structural materials inside. In the past, a CAD system Pro/Engineer and mesh generator Pointwise were evaluated for this application. But, the cost of those commercial CAD and mesh generator is sometimes a great burden. Therefore, efforts have been made to set up a mesh generation system with open source programs. The evaluation of the TetGen has been made in focusing the application for the polyhedral mesh generation. In this paper, SALOME will be evaluated for the efforts in conjunction with TetGen. In section 2, review will be made on the CAD and mesh generation capability of SALOME. SALOME and TetGen codes are being integrated to construct robust polyhedral mesh generator. Edge removal on the flat surface and vertex reattachment to the solid are two challenging tasks. It is worthwhile to point out that the Python script capability of the SALOME should be fully utilized for the future investigation.

EPCGen2 Pseudorandom Number Generators: Analysis of J3Gen

Directory of Open Access Journals (Sweden)

Alberto Peinado

2014-04-01

Full Text Available This paper analyzes the cryptographic security of J3Gen, a promising pseudo random number generator for low-cost passive Radio Frequency Identification (RFID tags. Although J3Gen has been shown to fulfill the randomness criteria set by the EPCglobal Gen2 standard and is intended for security applications, we describe here two cryptanalytic attacks that question its security claims: (i a probabilistic attack based on solving linear equation systems; and (ii a deterministic attack based on the decimation of the output sequence. Numerical results, supported by simulations, show that for the specific recommended values of the configurable parameters, a low number of intercepted output bits are enough to break J3Gen. We then make some recommendations that address these issues.

Estimación de parámetros genéticos para características productivas y reproductivas en los sistemas doble propósito del trópico bajo colombiano

Directory of Open Access Journals (Sweden)

A. P. Galeano

2010-06-01

Full Text Available Con el objetivo de estimar los componentes de varianza, las heredabilidades, repetibilidadesy correlaciones genéticas y fenotípicas para la producción de leche por lactancia(PL, el peso al destete (PD, el intervalo entre partos (IEP y el Índice de Vaca (IV,de las hembras bovinas manejadas en los sistemas de producción de doble propósitodel trópico bajo colombiano, se analizaron los registros productivos y reproductivosde 1.687 vacas registradas en la Asociación Colombiana de Criadores de Ganado enDoble Propósito (Asodoble, durante el periodo comprendido entre 1998 y 2007. Seempleó un modelo animal mixto que incluyó los efectos fijos del grupo contemporáneo(finca-sexo-época-año, la composición racial, y la duración de la lactancia comocovariable; así como los efectos genéticos aleatorios del animal, el medio ambientepermanente y el residual. Las heredabilidades estimadas para IEP (0,04 y PD (0,11fueron bajas, y moderadas para PL (0,35 e IV (0,24, respectivamente. La repetibilidadestimada para IEP fue baja (0,08, y para PL (0,41 e IV (0,31 moderada; en el casode PD este valor fue igual a la heredabilidad (0,11. Las correlaciones genéticas y fenotípicasobtenidas entre PL y PD con respecto a IEP fueron positivas, y se determinóuna asociación genética negativa entre PL y PD. Los resultados demostraron que el IVes un buen indicador, desde el punto de vista genético, de la eficiencia productiva yreproductiva de los animales manejados en estos sistemas productivos.

Development of digital materials database for design and construction of new power plants

International Nuclear Information System (INIS)

Ren, W.

2008-01-01

To facilitate materials selection, structural design, and future maintenance of the Generation IV nuclear reactor systems, an interactive, internet accessible materials property database, dubbed Gen IV Materials Handbook, has been under development with the support of the United States Department of Energy. The Handbook will provide an authoritative source of information on structural materials needed for the development of various Gen IV nuclear reactor systems along with powerful data analysis and management tools. In this paper the background, history, framework, major features, contents, and development strategy of the Gen IV Materials Handbook are discussed. Current development status and future plans are also elucidated. (authors)

Seleção preliminar de genótipos de pinheira em Bom Jesus-PI Preliminary selection of sugar apple genotypes in Bom Jesus county, Piauí state, Brazil

Directory of Open Access Journals (Sweden)

Ítalo Herbert Lucena Cavalcante

2011-01-01

Full Text Available A pinheira (Annona squamosa L. ocorre espontaneamente no Nordeste Brasileiro, onde é explorada de forma extrativista, caracterizando-se pela falta de manejo adequado e material genético selecionado. Nesse sentido, foi realizado um experimento com objetivo de avaliar a produtividade, as características físicas e químicas de frutos de dez genótipos de pinheira no município de Bom Jesus, PI. Adotou-se delineamento inteiramente casualizado, com tratamentos representados por dez genótipos de pinheira e três repetições. Foram avaliadas as seguintes variáveis: vitamina C, acidez titulável, sólidos solúveis, relação SS/AT "ratio", diâmetros longitudinal e transversal, relação DL/DT, número se sementes por fruto, massa dos frutos e produção por planta. Os genótipos apresentam diferenças quanto às características químicas, físicas e produtivas dos frutos. Os genótipos foram agrupados em sete grupos, com destaque para o grupo III (Gen-02 e grupo IV (Gen-05, fato que explicitou as diferenças entre os genótipos de pinheira quanto às características produtivas e químicas e físicas dos frutos. Genótipos Gen-01 e Gen-02 apresentam potencial para instalação em plantios comerciais, pela produtividade, formato do fruto ou por caracterizarem fontes naturais de vitamina C.The sugar apple (Annona squamosa L. is native to tropical America, occurring spontaneously in Northeastern Brazil, where it is exploited mainly as subsistence without adequate management and without genetic material selection. An experiment was developed aiming to evaluate yield, physical and chemical characteristics of the fruits of ten sugar apple genotypes in Bom Jesus, Piauí State, Brazil. A completely randomized design with treatments represented by ten genotypes and three replications was adopted. The following variables were evaluated: vitamin C, titratable acidity, soluble solids, SS/TA ratio, longitudinal diameter and transverse, LD/TD, number of

Divergência, variabilidade genética e desempenho agronômico em genótipos de couve.

OpenAIRE

Azevedo, Alcinei Mistico

2012-01-01

Embora haja grande variabilidade genética para a couve, são poucos trabalhos no Brasil que visão obter informações para programas de melhoramento genético nesta cultura. Assim, objetivou-se neste trabalho caracterizar 30 genótipos de couve a partir de caracteres morfo-agronômicos para estimar a divergência genética, a importância dos caracteres para a divergência, o desempenho agronômico, os parâmetros genéticos e a correlação entre as características avaliadas. O experimento foi conduzido na...

Identificación de mutaciones puntuales del gen de la 21-hidroxilasa en pacientes afectados con hiperplasia suprarrenal congénita.

Directory of Open Access Journals (Sweden)

Dora Fonseca

2005-06-01

Full Text Available lntroducción. La hiperplasia suprarrenal congénita es un trastorno autosómico recesivo debido a la inadecuada secreción de cortisol. Mas del 95% de los casos de hiperplasia suprarrenal congénita son causados por defectos del gen de la 21 hidroxilasa, CYP21A2 . Las manifestaciones clínicas incluyen la forma clásica y la forma no clásica. Objetivos. Determinar la frecuencia de las mutaciones puntuales P30L, IVS2-12AIC-G, Del 8pb, I172N, cluster Ex 6, V281L, Q318X, R356W y P453S en pacientes con hiperplasia suprarrenal congénita. Materiales y métodos. Se estudiaron 58 pacientes, de los cuales, 48 fueron clásicos y 10 no clásicos. Mediante PCR alelo-especifica y ACRS (Amplified Creation Restriction Sites, se analizaron 9 mutaciones puntuales del gen CYP21A2 y se determinó la frecuencia en la población analizada. Resultados. Los alelos afectados se identificaron en el 82,8% de los cromosomas. Las mutaciones mas frecuentes fueron: IVS2-12AIC-G (26,7%, Q318X (21,5%, V281L (12,1% e I172N (12,1%. Conclusiones. Las mutaciones mas frecuentes en Colombia son similares a las de otros países del mundo, excepto para Q318X que presentó una mayor frecuencia, pero similar a la de otros países latinoamericanos. Este hallazgo y la existencia de 17,2% de alelos no identificados puede indicar diferencia entre el acervo genético de las poblaciones. En la forma clásica perdedora de sal predominaron las mutaciones Q318X e IVS2-12AIC-G; en la virilizante simple, IVS2-12AIC-G e I172N y en la no clásica , V281L, lo cual esta relacionado con el grado de actividad enzimática. En la forma no clásica, se encontraron alelos severos en el 66,7% de los casos, lo que determina el riesgo de tener hijos afectados con la forma grave virilizante simple o perdedora de sal. Los resultados reportados permiten ofrecer asesoramiento genético y diagnóstico prenatal.

Thermodynamic data for predicting concentrations of Th(IV), U(IV), Np(IV), and Pu(IV) in geologic environments

Energy Technology Data Exchange (ETDEWEB)

Rai, Dhanpat; Roa, Linfeng; Weger, H.T.; Felmy, A.R. [Battelle, Pacific Northwest National Laboratory (PNNL) (United States); Choppin, G.R. [Florida State University (United States); Yui, Mikazu [Waste Isolation Research Division, Tokai Works, Japan Nuclear Cycle Development Inst., Tokai, Ibaraki (Japan)

1999-01-01

This report provides thermodynamic data for predicting concentrations of Th(IV), U(IV), Np(IV), and Pu(IV) in geologic environments, and contributes to an integration of the JNC chemical thermodynamic database, JNC-TDB (previously PNC-TDB), for the performance analysis of geological isolation system for high-level radioactive wastes. Thermodynamic data for the formation of complexes or compounds with hydroxide, chloride, fluoride, carbonate, nitrate, sulfate and phosphate are discussed in this report. Where data for specific actinide(IV) species was lacking, the data were selected based on chemical analogy to other tetravalent actinides. In this study, the Pitzer ion-interaction model is used to extrapolate thermodynamic constants to zero ionic strength at 25degC. (author)

Modcomp MAX IV System Processors reference guide

Energy Technology Data Exchange (ETDEWEB)

Cummings, J.

1990-10-01

A user almost always faces a big problem when having to learn to use a new computer system. The information necessary to use the system is often scattered throughout many different manuals. The user also faces the problem of extracting the information really needed from each manual. Very few computer vendors supply a single Users Guide or even a manual to help the new user locate the necessary manuals. Modcomp is no exception to this, Modcomp MAX IV requires that the user be familiar with the system file usage which adds to the problem. At General Atomics there is an ever increasing need for new users to learn how to use the Modcomp computers. This paper was written to provide a condensed Users Reference Guide'' for Modcomp computer users. This manual should be of value not only to new users but any users that are not Modcomp computer systems experts. This Users Reference Guide'' is intended to provided the basic information for the use of the various Modcomp System Processors necessary to, create, compile, link-edit, and catalog a program. Only the information necessary to provide the user with a basic understanding of the Systems Processors is included. This document provides enough information for the majority of programmers to use the Modcomp computers without having to refer to any other manuals. A lot of emphasis has been placed on the file description and usage for each of the System Processors. This allows the user to understand how Modcomp MAX IV does things rather than just learning the system commands.

The European gen-set market: growth and consolidation mean joy and pain

International Nuclear Information System (INIS)

French, Ian

2000-01-01

The changes in the European gen-set market are discussed. In recent years the market has undergone a period of increasing consolidation: prices fell and some companies folded. However, the market is not dead and continued growth is expected over the next five years although the compound rate is forecast to be only 1.5%. The article is presented under the sub-headings of (i) current market situation; (ii) product lifecycle; (iii) shipments by technology; (iv) market deregulation; (v) technology overview (spark ignition, compression ignition and gas turbines) (vi) European market: national overview and (vii) key market challenges (competition, emissions and over capacity)

Status of the Gen-IV Proliferation Resistance and Physical Protection (PRPP) Evaluation Methodology

International Nuclear Information System (INIS)

Whitlock, J.; Bari, R.; Peterson, P.; Padoani, F.; Cojazzi, G.G.M.; Renda, G.; ); Cazalet, J.; Haas, E.; Hori, K.; Kawakubo, Y.; Chang, S.; Kim, H.; Kwon, E.-H.; Yoo, H.; Chebeskov, A.; Pshakin, G.; Pilat, J.F.; Therios, I.; Bertel, E.

2015-01-01

Methodologies have been developed within the Generation IV International Forum (GIF) to support the assessment and improvement of system performance in the areas safeguards, security, economics and safety. Of these four areas, safeguards and security are the subjects of the GIF working group on Proliferation Resistance and Physical Protection (PRPP). Since the PRPP methodology (now at Revision 6) represents a mature, generic, and comprehensive evaluation approach, and is freely available on the GIF public website, several non-GIF technical groups have chosen to utilize the PRPP methodology for their own goals. Indeed, the results of the evaluations performed with the methodology are intended for three types of generic users: system designers, programme policy makers, and external stakeholders. The PRPP Working Group developed the methodology through a series of demonstration and case studies. In addition, over the past few years various national and international groups have applied the methodology to inform nuclear energy system designs, as well as to support the development of approaches to advanced safeguards. A number of international workshops have also been held which have introduced the methodology to design groups and other stakeholders. In this paper we summarize the technical progress and accomplishments of the PRPP evaluation methodology, including applications outside GIF, and we outline the PRPP methodology's relationship with the IAEA's INPRO methodology. Current challenges with the efficient implementation of the methodology are outlined, along with our path forward for increasing its accessibility to a broader stakeholder audience - including supporting the next generation of skilled professionals in the nuclear non-proliferation field. (author)

Variabilidad genética de Plasmodium falciparum en pacientes con malaria grave y malaria no complicada en Iquitos - Perú

Directory of Open Access Journals (Sweden)

Gisely Hijar G

2002-07-01

Full Text Available Objetivo: Determinar la diversidad genética del gen que codifica la proteína rica en glutamato (GLURP de Plasmodium falciparum en pacientes con malaria complicada y no complicada circulante en un área del departamento de Loreto, distrito de Maynas. Materiales y métodos: La diversidad genética fue analizada usando reacción en cadena de la polimerasa (PCR en 30 muestras sanguíneas de pacientes con malaria no complicada (MNC y 46 con malaria grave complicada (MGC. Resultados: Ocho genotipos fueron detectados en pacientes con MNC (Genotipo I,II,III, IV,V, VI,VII y VIII y cuatro genotipos en los pacientes con MGC (Genotipo V,VI,VII,VIII. Asimismo, en 50% de las muestras con MNC fueron detectadas infecciones múltiples, a diferencia de las muestras de MGC en donde no se detectó infecciones múltiples. Conclusión: Existe una diversidad genética en esta región del gen GLURP de P. falciparum, para esa época (marzo 1998 - abril 1999 y esa área del país. En tal sentido, nuestros resultados podrían servir de base para llevar a cabo estudios epidemiológicos posteriores, ya que permitiría conocer la distribución de las cepas circulantes en nuestro país.

PR and PP evaluation. ESFR full system case study final report (Tentative translation)

International Nuclear Information System (INIS)

Sagara, Hiroshi; Kawakubo, Yoko; Inoue, Naoko

2014-01-01

The Generation IV (GEN IV) International Forum (GIF) Proliferation Resistance and Physical Protection Working Group (PRPP WG) was established in December, 2002, as one of the crosscut groups under GIF, in order to develop a methodology for evaluating PR and PP of potential GEN IV options. The group currently consists of the experts from the U.S. national laboratories and universities, from Canada, France, Republic of Korea (ROK), Japan, the International Atomic Energy Agency (IAEA), and European Union(EU). The present report, published in Oct. 2009, was used as a supporting study for development of the evaluation methodology for proliferation resistance and physical protection of GEN IV nuclear energy systems. The present report is summarizing the case study of the PR and PP evaluation of Example Sodium Fast Reactor (ESFR), a hypothetical nuclear energy system consisting of nine main system elements, and it provides for designers the practical experience of applying the PR and PP evaluation methodology to a nuclear energy system. The development of the future nuclear fuel cycle system with sufficient PR and PP features is a crucial task in Japan, and the demonstration and explanation about its effectiveness to the domestic and international society will be required. With the usefulness the present report for such purposes, it was translated and published here as a Japanese-language edition with the concurrence of the OECD-NEA. The original report in English language can be downloaded at the OECD-NEA website. The translation was performed as closely as possible to the original, and special attention was paid to the technical term translation for consistency. Terms difficult to be translated appropriately into Japanese was written with the original English wording. Safeguards terms were translated with reference to “IAEA Safeguards Glossary 2001 Edition” (Japanese), published by the Nuclear Material Control Center Japan (NMCC). The authors are grateful to the GIF

GenLab, Laboratorio Virtual de Genética

Directory of Open Access Journals (Sweden)

Fidel Ramírez

2000-07-01

Full Text Available GenLab es el nombre que tiene el software diseñado por nosotros, en el cual se modela el proceso meiótico y la fecundación en organismos diploides. El objetivo de esta aplicación es ilustrar el resultado de un cruce determinado, tratando de ser lo más ajustados a la realidad. La modelación de la reproducción sexual se realiza internamente y el GenLab se limita a presentar los resultados según el número de descendencia seleccionado para un cruce específico, esto significa que se puede escoger una gran cantidad de características para los parentales y se puede estudiar la frecuencia de estos en la descendencia. El modelo cuenta con base de datos donde están almacenados algunos de los locus de Drosophila melanogaster junto con su ubicación en centimorgans 1. EI propósito de este modelo es servir como herramienta pedagógica  y didáctica tanto en universidades como en colegios, facilitando el aprendizaje de algunos principios básicos de la genética, por lo cual puede ser usado si se cuenta con una conexión a Internet y un navegador visitando http://biologia.unal.edu.co/fidel.

Description of the IV + V System Software Package.

Science.gov (United States)

Microcomputers for Information Management: An International Journal for Library and Information Services, 1984

1984-01-01

Describes the IV + V System, a software package designed by the Institut fur Maschinelle Dokumentation for the United Nations General Information Programme and UNISIST to support automation of local information and documentation services. Principle program features and functions outlined include input/output, databank, text image, output, and…

Seleção de genótipos parentais de acerola com base na divergência genética multivariada

Directory of Open Access Journals (Sweden)

CARPENTIERI-PÍPOLO VALÉRIA

2000-01-01

Full Text Available Este trabalho teve por objetivo identificar e selecionar genótipos parentais de acerola (Malpighia emarginata L. adequadas a programas de melhoramento genético. Nove caracteres quantitativos de maior importância agronômica foram usados para determinação da distância genética e formação de grupos similares de acessos. O agrupamento pelo método de Tocher, a partir das distâncias generalizadas de Mahalanobis, possibilitou a divisão de 14 genótipos em três grupos. Com base na divergência genética e no caráter agronômico-chave (teor de vitamina C, destacaram-se como mais promissores os cruzamentos dos genótipos: AM Mole pertencente ao grupo III, com os genótipos PR AM, N° 18, PR 17, PR 16, Eclipse, AM 22 e Dominga, todos pertencentes ao grupo I.

Motion control system of MAX IV Laboratory soft x-ray beamlines

International Nuclear Information System (INIS)

Sjöblom, Peter; Lindberg, Mirjam; Forsberg, Johan; Persson, Andreas G.; Urpelainen, Samuli; Såthe, Conny

2016-01-01

At the MAX IV Laboratory, five new soft x-ray beamlines are under development. The first is Species and it will be used to develop and set the standard of the control system, which will be common across the facility. All motion axes at MAX IV will be motorized using stepper motors steered by the IcePAP motion controller and a mixture of absolute and incremental encoders following a predefined coordinate system. The control system software is built in Tango and uses the Python-based Sardana framework. The user controls the entire beamline through a synoptic overview and Sardana is used to run the scans.

Motion control system of MAX IV Laboratory soft x-ray beamlines

Energy Technology Data Exchange (ETDEWEB)

Sjöblom, Peter, E-mail: peter.sjoblom@maxlab.lu.se; Lindberg, Mirjam, E-mail: mirjam.lindberg@maxlab.lu.se; Forsberg, Johan, E-mail: johan.forsberg@maxlab.lu.se; Persson, Andreas G., E-mail: andreas-g.persson@maxlab.lu.se; Urpelainen, Samuli, E-mail: samuli.urpelainen@maxlab.lu.se; Såthe, Conny, E-mail: conny.sathe@maxlab.lu.se [MAX IV Laboratory, Photongatan 2, 225 92 Lund (Sweden)

2016-07-27

At the MAX IV Laboratory, five new soft x-ray beamlines are under development. The first is Species and it will be used to develop and set the standard of the control system, which will be common across the facility. All motion axes at MAX IV will be motorized using stepper motors steered by the IcePAP motion controller and a mixture of absolute and incremental encoders following a predefined coordinate system. The control system software is built in Tango and uses the Python-based Sardana framework. The user controls the entire beamline through a synoptic overview and Sardana is used to run the scans.

SIPSMetGen: It's Not Just For Aircraft Data and ECS Anymore.

Science.gov (United States)

Schwab, M.

2015-12-01

The SIPSMetGen utility, developed for the NASA EOSDIS project, under the EED contract, simplified the creation of file level metadata for the ECS System. The utility has been enhanced for ease of use, efficiency, speed and increased flexibility. The SIPSMetGen utility was originally created as a means of generating file level spatial metadata for Operation IceBridge. The first version created only ODL metadata, specific for ingest into ECS. The core strength of the utility was, and continues to be, its ability to take complex shapes and patterns of data collection point clouds from aircraft flights and simplify them to a relatively simple concave hull geo-polygon. It has been found to be a useful and easy to use tool for creating file level metadata for many other missions, both aircraft and satellite. While the original version was useful it had its limitations. In 2014 Raytheon was tasked to make enhancements to SIPSMetGen, this resulted a new version of SIPSMetGen which can create ISO Compliant XML metadata; provides optimization and streamlining of the algorithm for creating the spatial metadata; a quicker runtime with more consistent results; a utility that can be configured to run multi-threaded on systems with multiple processors. The utility comes with a java based graphical user interface to aid in configuration and running of the utility. The enhanced SIPSMetGen allows more diverse data sets to be archived with file level metadata. The advantage of archiving data with file level metadata is that it makes it easier for data users, and scientists to find relevant data. File level metadata unlocks the power of existing archives and metadata repositories such as ECS and CMR and search and discovery utilities like Reverb and Earth Data Search. Current missions now using SIPSMetGen include: Aquarius, Measures, ARISE, and Nimbus.

45 CFR 310.5 - What options are available for Computerized Tribal IV-D Systems and office automation?

Science.gov (United States)

2010-10-01

... IV-D Systems and office automation? 310.5 Section 310.5 Public Welfare Regulations Relating to Public... AUTOMATION Requirements for Computerized Tribal IV-D Systems and Office Automation § 310.5 What options are available for Computerized Tribal IV-D Systems and office automation? (a) Allowable computerized support...

AtlA functions as a peptidoglycan lytic transglycosylase in the Neisseria gonorrhoeae type IV secretion system.

Science.gov (United States)

Kohler, Petra L; Hamilton, Holly L; Cloud-Hansen, Karen; Dillard, Joseph P

2007-08-01

Type IV secretion systems require peptidoglycan lytic transglycosylases for efficient secretion, but the function of these enzymes is not clear. The type IV secretion system gene cluster of Neisseria gonorrhoeae encodes two peptidoglycan transglycosylase homologues. One, LtgX, is similar to peptidoglycan transglycosylases from other type IV secretion systems. The other, AtlA, is similar to endolysins from bacteriophages and is not similar to any described type IV secretion component. We characterized the enzymatic function of AtlA in order to examine its role in the type IV secretion system. Purified AtlA was found to degrade macromolecular peptidoglycan and to produce 1,6-anhydro peptidoglycan monomers, characteristic of lytic transglycosylase activity. We found that AtlA can functionally replace the lambda endolysin to lyse Escherichia coli. In contrast, a sensitive measure of lysis demonstrated that AtlA does not lyse gonococci expressing it or gonococci cocultured with an AtlA-expressing strain. The gonococcal type IV secretion system secretes DNA during growth. A deletion of ltgX or a substitution in the putative active site of AtlA severely decreased DNA secretion. These results indicate that AtlA and LtgX are actively involved in type IV secretion and that AtlA is not involved in lysis of gonococci to release DNA. This is the first demonstration that a type IV secretion peptidoglycanase has lytic transglycosylase activity. These data show that AtlA plays a role in type IV secretion of DNA that requires peptidoglycan breakdown without cell lysis.

FutureGen Project Report

Energy Technology Data Exchange (ETDEWEB)

Cabe, Jim; Elliott, Mike

2010-09-30

This report summarizes the comprehensive siting, permitting, engineering, design, and costing activities completed by the FutureGen Industrial Alliance, the Department of Energy, and associated supporting subcontractors to develop a first of a kind near zero emissions integrated gasification combined cycle power plant and carbon capture and storage project (IGCC-CCS). With the goal to design, build, and reliably operate the first IGCC-CCS facility, FutureGen would have been the lowest emitting pulverized coal power plant in the world, while providing a timely and relevant basis for coal combustion power plants deploying carbon capture in the future. The content of this report summarizes key findings and results of applicable project evaluations; modeling, design, and engineering assessments; cost estimate reports; and schedule and risk mitigation from initiation of the FutureGen project through final flow sheet analyses including capital and operating reports completed under DOE award DE-FE0000587. This project report necessarily builds upon previously completed siting, design, and development work executed under DOE award DE-FC26- 06NT4207 which included the siting process; environmental permitting, compliance, and mitigation under the National Environmental Policy Act; and development of conceptual and design basis documentation for the FutureGen plant. For completeness, the report includes as attachments the siting and design basis documents, as well as the source documentation for the following: • Site evaluation and selection process and environmental characterization • Underground Injection Control (UIC) Permit Application including well design and subsurface modeling • FutureGen IGCC-CCS Design Basis Document • Process evaluations and technology selection via Illinois Clean Coal Review Board Technical Report • Process flow diagrams and heat/material balance for slurry-fed gasifier configuration • Process flow diagrams and heat/material balance

Teleport Generation 3 (Teleport Gen 3)

Science.gov (United States)

2016-03-01

for high- throughput multi-band and multimedia connectivity from deployed locations to DISN and DoD Information Network (DoDIN) information sources and...2016 Major Automated Information System Annual Report Teleport Generation 3 (Teleport Gen 3) Defense Acquisition Management Information Retrieval...Program Information 4 Responsible Office 4 References 4 Program Description 5 Business Case 6 Program Status 8 Schedule 9

A 48-plex autosomal SNP GenPlex™ assay for human individualization and relationship testing

DEFF Research Database (Denmark)

Tomas Mas, Carmen; Børsting, Claus; Morling, Niels

2012-01-01

SNPs are being increasingly used by forensic laboratories. Different platforms have been developed for SNP typing. We describe the GenPlex™ HID system protocol, a new SNP-typing platform developed by Applied Biosystems where 48 of the 52 SNPforID SNPs and amelogenin are included. The GenPlex™ HID...

Effects of Ta addition on the Microstructural and Mechanical Properties of 9Cr-0.5Mo-2W F/M Steels for a SFR Fuel Cladding

International Nuclear Information System (INIS)

Baek, Jong-Hyuk; Han, Chang-Hee; Kim, Tae-Kyu; Kim, Sung-Ho; Lee, Chan-Bock

2007-01-01

Today twenty fission reactors provide about 40% of the domestic electricity supply. The world-wide distribution of some nuclear reactors will be aging and will need replacement and enhancement to both keep pace with and to take up a large share of the growing world-wide electricity demand. A new generation (Gen IV) of nuclear plant concepts has become the focus of international advanced reactor activity. Gen IV nuclear systems embodies greater improvements and innovative advances in technology over earlier ones. The Gen IV systems are to have a considerable increase in safety and be economically competitive when compared with the existed commercial reactors. In particular, the systems should produce a significantly reduced volume of nuclear wastes. From this point of view, sodium-cooled Fast Reactor (SFR) is strongly considered as a future nuclear energy system in Korea

Evaluation and optimization of General Atomics' GT-MHR reactor cavity cooling system using an axiomatic design approach

International Nuclear Information System (INIS)

Thielman, Jeff; Ge, Ping; Wu, Qiao; Parme, Laurence

2005-01-01

The development of the Generation IV (Gen-IV) nuclear reactors has presented social, technical, and economical challenges to nuclear engineering design and research. To develop a robust, reliable nuclear reactor system with minimal environmental impact and cost, modularity has been gradually accepted as a key concept in designing high-quality nuclear reactor systems. While the establishment and reliability of a nuclear power plant is largely facilitated by the installment of standardized base units, the realization of modularity at the sub-system/sub-unit level in a base unit is still highly heuristic, and lacks consistent, quantifiable measures. In this work, an axiomatic design approach is developed to evaluate and optimize the reactor cavity cooling system (RCCS) of General Atomics' Gas Turbine-Modular Helium Reactor (GT-MHR) nuclear reactor, for the purpose of constructing a quantitative tool that is applicable to Gen-IV systems. According to Suh's axiomatic design theory, modularity is consistently represented by functional independence through the design process. Both qualitative and quantitative measures are developed here to evaluate the modularity of the current RCCS design. Optimization techniques are also used to improve the modularity at both conceptual and parametric level. The preliminary results of this study have demonstrated that the axiomatic design approach has great potential in enhancing modular design, and generating more robust, safer, and less expensive nuclear reactor sub-units

Análise de distância genética entre acessos do gênero Psidium via marcadores ISSR

Directory of Open Access Journals (Sweden)

Názila Nayara Silva de Oliveira

2014-12-01

Full Text Available O objetivo deste trabalho foi avaliar a distância genética entre 37 acessos da espécie cultivada Psidium guajava, L. (goiaba e de araçás do gênero Psidium do banco de germoplasma da Universidade Estadual do Norte Fluminense (UENF, via marcadores moleculares ISSR. Nos 17 marcadores selecionados, foram obtidas 216 bandas polimórficas. Pelo método de agrupamento UPGMA, houve a formação de cinco principais grupos. Os acessos de araçá da espécie P. cattleyanum Sabine , ficaram alocados nos grupos I e II. No grupo II, foi observada, dentro da espécie P cattleyanum, maior proximidade com a goiabeira. No grupo III, ficou alocado o acesso da espécie P. guineense Sw (araçá-do-campo e dentre os araçás, foi o que ficou mais próximo da goiaba. Os genótipos de goiabeira ficaram alocados do grupo IV e V, confirmando sua alta divergência. Os marcadores moleculares foram eficientes em estimar a distância genética intra e interespecífica.

GenColors-based comparative genome databases for small eukaryotic genomes.

Science.gov (United States)

Felder, Marius; Romualdi, Alessandro; Petzold, Andreas; Platzer, Matthias; Sühnel, Jürgen; Glöckner, Gernot

2013-01-01

Many sequence data repositories can give a quick and easily accessible overview on genomes and their annotations. Less widespread is the possibility to compare related genomes with each other in a common database environment. We have previously described the GenColors database system (http://gencolors.fli-leibniz.de) and its applications to a number of bacterial genomes such as Borrelia, Legionella, Leptospira and Treponema. This system has an emphasis on genome comparison. It combines data from related genomes and provides the user with an extensive set of visualization and analysis tools. Eukaryote genomes are normally larger than prokaryote genomes and thus pose additional challenges for such a system. We have, therefore, adapted GenColors to also handle larger datasets of small eukaryotic genomes and to display eukaryotic gene structures. Further recent developments include whole genome views, genome list options and, for bacterial genome browsers, the display of horizontal gene transfer predictions. Two new GenColors-based databases for two fungal species (http://fgb.fli-leibniz.de) and for four social amoebas (http://sacgb.fli-leibniz.de) were set up. Both new resources open up a single entry point for related genomes for the amoebozoa and fungal research communities and other interested users. Comparative genomics approaches are greatly facilitated by these resources.

StateGEN/StateNET - A structured method to perform route comparisons

International Nuclear Information System (INIS)

Cashwell, J.W.; Erickson, C.M.

1989-01-01

StateGEN/StateNET is a modeling structure and routing algorithm designed expressly to address the needs of state and local governments to perform analyses of routing alternatives. StateGEN/StateNET is designed to permit the user to construct a network and assign attributes of interest to the network on a personal computer (PC). The completed network is then transferred via a modem to the TRANSNET system and the preferred route is determined based upon attribute weights assigned by the user. This modeling structure permits the state or local government to perform a routing analysis, such as that required by the US Department of Transportation (DOT) for Highway Route-Controlled Quantity shipments of radioactive materials, with a minimum of resources. StateGEN/StateNET provides a computerized version of the DOT guidelines or allows the user to structure their own network parameters. Sandia National Laboratories (SNL) is the Department of Energy (DOE) lead organization for transportation research and development. The DOE Office of Defense Programs has been the prime sponsor of development of models and associated databases used to analyze the impacts of the transportation of radioactive materials. The routing algorithms used in StateGEN/StateNET were based on the existing models on TRANSNET, a system which was developed to enable outside users to access analytical codes and associated data developed for the DOE

StateGEN/StateNET--A structured method to perform route comparisons

International Nuclear Information System (INIS)

Cashwell, J.W.; Erickson, C.M.

1989-01-01

StateGEN/StateNET is a modelling structure and routing algorithm designed expressly to address the needs of state and local governments to perform analyses of routing alternatives. StateGEN/StateNET is designed to permit the user to construct a network and assign attributes of interest to the network on a personal computer (PC). The completed network is then transferred via a modem to the TRANSNET system (Cashwell, 1989) and the preferred route is determined based upon attribute weights assigned by the user. This modelling structure permits the state or local to perform a routing analysis, such as that required by the US Department of Transportation (DOT) for Highway Route-Controlled Quantity shipments of radioactive materials, with a minimum of resources. StateGEN/StateNET provides a computerized version of the DOT guidelines (Cashwell, 1989) or allows the user to structure their own network parameters. Sandia national Laboratories (SNL) is the Department of Energy's (DOE) lead organization for transportation research and development. The DOE Office of Defense Programs has been the prime sponsor of development of models and associated databases used to analyze the impacts of the transportation of radioactive materials. The routing algorithms used in StateGEN/StateNET were based on the existing models on TRANSNET, a system which was developed to enable outside users to access analytical codes and associated data developed for the DOE. 2 refs

Safety design approach for JSFR toward the realization of GEN IV SFR

International Nuclear Information System (INIS)

Kubo, S.; Yamano, H.; Chikazawa, Y.; Shimakawa, Y.

2013-01-01

Conclusion: Safety Design Approach for JSFR: • Based on the safety design criteria for Generation-IV SFR • DECs, Situations practically eliminated and related design measures are identified and selected with due consideration of the safety features of SFR and the lessons learned from the TEPCO’s Fukushima Dai-ichi nuclear power plants accident Safety Design Concept of JSFR: • For failure to shutdown: Passive shutdown capability, Mitigation of core damage (Prevention of severe mechanical energy release, In-Vessel Retention) • For failure to remove heat: Prevention of significant core damage (Natural circulation DHR, Alternative cooling measures) • Containment: Prevention of sever dynamic loads by design measures (IVR, double boundary concept, inertization)

Nuclear Fuel Cycle System Analysis (I)

Energy Technology Data Exchange (ETDEWEB)

Ko, Won Il; Kwon, Eun Ha; Kim, Ho Dong; Yoon, Ji Sup; Park, Seong Won

2006-12-15

As a nation develops strategies that provide nuclear energy while meeting its various objectives, it must begin with identification of a fuel cycle option that can be best suitable for the country. For such a purpose, this paper takes four different fuel cycle options - Once-through Cycle, DUPIC Recycle, Thermal Reactor Recycle and GEN-IV Recycle, and evaluates each option in terms of sustainability, environment-friendliness, proliferation-resistance and economics. The analysis shows that the GEN-IV Recycle appears to have an advantage in terms of sustainability, environment-friendliness and long-term proliferation-resistance, while it is expected to be more economically competitive, if uranium ore prices increase or costs of pyroprocessing and fuel fabrication decrease.

Recommendations and Requirements for GenCade Simluations

Science.gov (United States)

2014-08-01

will report whether or not GenCade is enabled. If GenCade is disabled , the user will need a new license that includes GenCade...any depth but usually are not deeper than the seaward edge of the surf - zone. In the same way that some shorelines are less desirable for use in...Conference, 1919–1937. ASCE. Wang, P., N. C. Kraus, and R. A. Davis. 1998. Total rate of longshore sediment transport in the surf zone: Field

45 CFR 310.25 - What conditions apply to acquisitions of Computerized Tribal IV-D Systems?

Science.gov (United States)

2010-10-01

... FAMILIES, DEPARTMENT OF HEALTH AND HUMAN SERVICES COMPUTERIZED TRIBAL IV-D SYSTEMS AND OFFICE AUTOMATION Funding for Computerized Tribal IV-D Systems and Office Automation § 310.25 What conditions apply to... 45 Public Welfare 2 2010-10-01 2010-10-01 false What conditions apply to acquisitions of...

Unleashing Gen Y: Marketing Mars to Millennials

Science.gov (United States)

Leahy, Bart D.; Hidalgo, Loretta; Kloberdanz, Cassie

2007-01-01

Space advocates need to engage Generation Y (born 1977-1999).This outreach is necessary to recruit the next generation of scientists and engineers to explore Mars. Space advocates in the non-profit, private, and government sectors need to use a combination of technical communication, marketing, and politics, to develop messages that resonate with Gen Y. Until now, space messages have been generated by and for college-educated white males; Gen Y is much more diverse, including as much as one third minorities. Young women, too, need to be reached. My research has shown that messages emphasizing technology, fun, humor, and opportunity are the best means of reaching the Gen Y audience of 60 million (US population is 300 million). The important things space advocates must avoid are talking down to this generation, making false promises, or expecting them to "wait their turn" before they can participate. This is the MTV generation! We need to find ways of engaging Gen Y now to build a future where human beings can live and work on the planet Mars. In addition to the messages themselves, advocates need to keep up with Gen Y' s social networking and use of iPods, cell phones, and the Internet. NASA and space advocacy groups can use these tools for "viral marketing," where young people share targeted space-related information via cell phones or the Internet because they like it. Overall, Gen Y is a socially dynamic and media-savvy group; advocates' space messages need to be sincere, creative, and placed in locations where Gen Y lives. Mars messages must be memorable!

Tools for Designing, Evaluating, and Certifying NextGen Technologies and Procedures: Automation Roles and Responsibilities

Science.gov (United States)

Kanki, Barbara G.

2011-01-01

Barbara Kanki from NASA Ames Research Center will discuss research that focuses on the collaborations between pilots, air traffic controllers and dispatchers that will change in NextGen systems as automation increases and roles and responsibilities change. The approach taken by this NASA Ames team is to build a collaborative systems assessment template (CSAT) based on detailed task descriptions within each system to establish a baseline of the current operations. The collaborative content and context are delineated through the review of regulatory and advisory materials, policies, procedures and documented practices as augmented by field observations and interviews. The CSAT is developed to aid the assessment of key human factors and performance tradeoffs that result from considering different collaborative arrangements under NextGen system changes. In theory, the CSAT product may be applied to any NextGen application (such as Trajectory Based Operations) with specified ground and aircraft capabilities.

Status of the Polyhedral Mesh Generator using SALOME PLATFORM and TetGen

International Nuclear Information System (INIS)

Lee, Sang Yong; Park, Chan Eok; Kim, Shin Whan

2014-01-01

Recently developed porous body approach codes such as SPACE and CUPID require a CAD system to estimate the porosity. Since they use the unstructured mesh and they also require reliable mesh generation system. The combination of CAD system and mesh generation system is necessary to cope with a large number of cells and the complex fluid system with structural materials inside. In the past, a CAD system Pro/Engineer and mesh generator Pointwise were evaluated for this application. But, the cost of those commercial CAD and mesh generator is sometimes a great burden. Therefore, efforts have been made to set up a mesh generation system with open source programs. The evaluation of the TetGen has been made in focusing the application for the polyhedral mesh generation. In this paper, SALOME will be described for the efforts to combine TetGen with it. In section 2, brief introduction will be made on the CAD and mesh generation capability of SALOME and Tetgen. SALOME and TetGen codes are being integrated to construct robust polyhedral mesh generator. Procedures to merge boundary faces and to cut concave cells are developed to remove concave cells to get final convex polyhedral mesh. Treating the internal boundary face, i.e. non-manifold face will be the next task in the future investigation

Generation IV Nuclear Energy Systems Ten-Year Program Plan Fiscal Year 2005, Volume 1

International Nuclear Information System (INIS)

None

2005-01-01

As reflected in the U.S. ''National Energy Policy'', nuclear energy has a strong role to play in satisfying our nation's future energy security and environmental quality needs. The desirable environmental, economic, and sustainability attributes of nuclear energy give it a cornerstone position, not only in the U.S. energy portfolio, but also in the world's future energy portfolio. Accordingly, on September 20, 2002, U.S. Energy Secretary Spencer Abraham announced that, ''The United States and nine other countries have agreed to develop six Generation IV nuclear energy concepts''. The Secretary also noted that the systems are expected to ''represent significant advances in economics, safety, reliability, proliferation resistance, and waste minimization''. The six systems and their broad, worldwide research and development (R and D) needs are described in ''A Technology Roadmap for Generation IV Nuclear Energy Systems'' (hereafter referred to as the Generation IV Roadmap). The first 10 years of required U.S. R and D contributions to achieve the goals described in the Generation IV Roadmap are outlined in this Program Plan

Modelo poblacional con algoritmos genéticos

OpenAIRE

Veliz Quintero, Eduardo; Rodriguez Ojeda, Luis

2009-01-01

Para el desarrollo de este trabajo, “MODELO POBLACIONAL CON ALGORITMOS GENÉTICOS”, he investigado la rama de la inteligencia artificial, como son los algoritmos genéticos. Primero presento en forma general los aspectos que envuelven los algoritmos genéticos, parto de la necesidad de optimizar, así como su historia y posibles aplicaciones y luego he cubierto detalladamente todo lo que pude investigar sobre la teoría de los algoritmos genéticos, sus fundamentos matemáticos, tipos de algoritmos ...

pGenN, a Gene Normalization Tool for Plant Genes and Proteins in Scientific Literature

Science.gov (United States)

Ding, Ruoyao; Arighi, Cecilia N.; Lee, Jung-Youn; Wu, Cathy H.; Vijay-Shanker, K.

2015-01-01

Background Automatically detecting gene/protein names in the literature and connecting them to databases records, also known as gene normalization, provides a means to structure the information buried in free-text literature. Gene normalization is critical for improving the coverage of annotation in the databases, and is an essential component of many text mining systems and database curation pipelines. Methods In this manuscript, we describe a gene normalization system specifically tailored for plant species, called pGenN (pivot-based Gene Normalization). The system consists of three steps: dictionary-based gene mention detection, species assignment, and intra species normalization. We have developed new heuristics to improve each of these phases. Results We evaluated the performance of pGenN on an in-house expertly annotated corpus consisting of 104 plant relevant abstracts. Our system achieved an F-value of 88.9% (Precision 90.9% and Recall 87.2%) on this corpus, outperforming state-of-art systems presented in BioCreative III. We have processed over 440,000 plant-related Medline abstracts using pGenN. The gene normalization results are stored in a local database for direct query from the pGenN web interface (proteininformationresource.org/pgenn/). The annotated literature corpus is also publicly available through the PIR text mining portal (proteininformationresource.org/iprolink/). PMID:26258475

Factors Influencing Retention of Gen Y and Non-Gen Y Teachers Working at International Schools in Asia

Science.gov (United States)

Fong, Hoi Wah Benny

2018-01-01

Quantitative studies on international-school teacher retention are few, especially studies that differentiate between Gen Y and non-Gen Y teachers. This article reports on the findings of a study that examined the relationship of job satisfaction factors to the likelihood of contract renewal by international-school teachers. Results from the study…

Metode Transfer Asam Nukleat sebagai Dasar Terapi Gen

Directory of Open Access Journals (Sweden)

Novi Silvia Hardiany

2017-01-01

Full Text Available Kemajuan ilmu biologi molekuler memberikan manfaat dalam bidang kedokteran untuk mengembangkanterapi gen. Tujuan terapi gen adalah untuk memperbaiki kerusakan gen atau mengganti gen yang rusakdengan gen yang normal. Pemindahan gen dilakukan dengan teknik transfeksi. Transfeksi merupakanproses pemindahan asam nukleat baik menggunakan vektor virus (transduksi atau menggunakan metodenonviral yaitu zat kimia, lipid dan metode fisik. Vektor virus yang digunakan pada transduksi adalahretrovirus, adenovirus, adeno-associated virus (AAV dan herpes simplex virus (HSV. Keberhasilantransfeksi ditentukan oleh berbagai faktor yang dapat dapat dinilai dengan menggunakan reporter sepertigreen fluorescence protein (GFP. Kata Kunci: terapi gen, transfeksi non viral, transduksi, vektor virus   Methods of Nucleic Acid Transfer as Basic Gene Therapy Abstract The advancement of molecular biology provides benefit in the field of medicine to develop genetherapy. The aim of gene therapy is to repair the genetic damage or to replace damaged gene with thenormal gene. Delivery of gene is carried out by transfection technique, a technique to transfer nucleic acidinto eukaryote cells either using viral vectors (known as transduction, and also using non viral methodsuch as chemical substance, lipid and physical method. Some of the viral vectors used in the transductionare retrovirus, adenovirus, Adeno-associated virus (AAV and Herpes Simplex Virus (HSV. The success oftransfection is determined by various factors which can be assessed using several reporters such as GreenFluorescence Protein (GFP. Key words: gene therapy, non viral transfection, transduction, viral vector. Normal 0 false false false IN X-NONE X-NONE

Data-Link and Surface Map Traffic Intent Displays for NextGen 4DT and Equivalent Visual Surface Operations

Science.gov (United States)

Shelton, Kevin J.; Prinzel, Lawrence J., III; Arthur, Jarvis J., III; Jones, Deise R.; Allamandola, Angela S.; Bailey, Randall E.

2009-01-01

By 2025, U.S. air traffic is predicted to increase 3-fold and may strain the current air traffic management system, which may not be able to accommodate this growth. In response to this challenge, a consortium of industry, academia and government agencies have proposed a revolutionary new concept for U.S. aviation operations, termed the Next Generation Air Transportation System or "NextGen". Many key capabilities are being identified to enable NextGen, including the concept of "net-centric" operations whereby each aircraft and air services provider shares information to allow real-time adaptability to ever-changing factors such as weather, traffic, flight trajectories, and security. Data-link is likely to be the primary source of communication in NextGen. Because NextGen represents a radically different approach to air traffic management and requires a dramatic shift in the tasks, roles, and responsibilities for the flight deck, there are numerous research issues and challenges that must be overcome to ensure a safe, sustainable air transportation system. Flight deck display and crew-vehicle interaction concepts are being developed that proactively investigate and overcome potential technology and safety barriers that might otherwise constrain the full realization of NextGen.

Perda auditiva genética Genetic hearing loss

Directory of Open Access Journals (Sweden)

Ricardo Godinho

2003-01-01

Full Text Available O progresso das pesquisas relacionadas à perda auditiva genética tem provocado um importante avanço do entendimento dos mecanismos moleculares que governam o desenvolvimento, a função, a resposta ao trauma e o envelhecimento do ouvido interno. Em países desenvolvidos, mais de 50% dos casos de surdez na infância é causada por alterações genéticas e as perdas auditivas relacionadas à idade têm sido associadas com mecanismos genéticos. OBJETIVO: O objetivo desta revisão é relatar as informações mais recentes relacionadas às perdas audtivas de origem genética. FORAMA DE ESTUDO: Revisão sistemática. MATERIAL E MÉTODO: A revisão da literatura inclui artigos indexados à MEDLINE (Biblioteca Nacional de Saúde, NIH-USA e publicados nos últimos 3 anos, além das informações disponíveis na Hereditary Hearing Loss Home Page. CONCLUSÃO: Os recentes avanços no entendimento das perdas auditivas de origem genética têm favorecido a nossa compreensão da função auditiva e tornado o diagnóstico mais apurado. Possivelmente, no futuro, este conhecimento também proporcionará o desenvolvimento de novas terapias para o tratamento das causas genéticas das perdas auditivas.The progress in the research of genetic hearing loss has advanced our understanding of the molecular mechanisms that govern inner ear development, function and response to injury and aging. In the developed world, over 50% of childhood deafness is attributable to genetic causes and even age-related hearing loss has been associated with genetic mechanisms. AIM: The objective of this review is to summarize recent knowledge in genetic hearing loss. STUDY DESIGN: Sistematic review. MATERIAL AND METHODS: The literature review included articles indexed at MEDLINE (The National Library of Medicine, The National Institute of Health - USA focusing on publications from the past 3 years plus the information available at the Hereditary Hearing Loss Home Page. CONCLUSION

Evaluation of Mixed-Mode Data-Link Communications for NextGen 4DT and Equivalent Visual Surface Operations

Science.gov (United States)

Prinzel, Lawrence J., III; Shelton, Kevin J.; Jones, Denise R.; Allamandola, Angela S.; Arthur, Jarvis, J., III; Bailey, Randall E.

2010-01-01

By 2025, U.S. air traffic is predicted to increase 3-fold and may strain the current air traffic management system, which may not be able to accommodate this growth. In response to this challenge, a revolutionary new concept has been proposed for U.S. aviation operations, termed the Next Generation Air Transportation System or NextGen. Many key capabilities are being identified to enable NextGen, including the use of data-link communications. Because NextGen represents a radically different approach to air traffic management and requires a dramatic shift in the tasks, roles, and responsibilities for the flight deck, there are numerous research issues and challenges that must be overcome to ensure a safe, sustainable air transportation system. Flight deck display and crew-vehicle interaction concepts are being developed that proactively investigate and overcome potential technology and safety barriers that might otherwise constrain the full realization of NextGen. The paper describes simulation research examining data-link communications during 4DT and equivalent visual surface operations.

Caracterização genético-clínica de pacientes com fenilcetonúria no Estado de Alagoas = Genetic and clinical characterization of patients with phenylketonuria in Alagoas state, Brazil

Directory of Open Access Journals (Sweden)

Santos, Emerson Santana

2012-01-01

Conclusões: O genótipo V388M/IVS10nt11G>A foi o mais prevalente. Trinta por cento dos pacientes foram sintomáticos, provavelmente pela natureza das mutações, não adesão ao tratamento, tratamento inadequado e/ou diagnóstico tardio

Characterization of Romboutsia ilealis gen. nov., sp. nov., isolated from the gastro-intestinal tract of a rat, and proposal for the reclassification of five closely related members of the genus Clostridium into the genera Romboutsia gen. nov., Intestinibacter gen. nov., Terrisporobacter gen. nov. and Asaccharospora gen. nov.

Science.gov (United States)

Gerritsen, Jacoline; Fuentes, Susana; Grievink, Wieke; van Niftrik, Laura; Tindall, Brian J; Timmerman, Harro M; Rijkers, Ger T; Smidt, Hauke

2014-05-01

A Gram-positive staining, rod-shaped, non-motile, spore-forming obligately anaerobic bacterium, designated CRIBT, was isolated from the gastro-intestinal tract of a rat and characterized. The major cellular fatty acids of strain CRIBT were saturated and unsaturated straight-chain C12-C19 fatty acids, with C16:0 being the predominant fatty acid. The polar lipid profile comprised six glycolipids, four phospholipids and one lipid that did not stain with any of the specific spray reagents used. The only quinone was MK-6. The predominating cell-wall sugars were glucose and galactose. The peptidoglycan type of strain CRIBT was A1σ lanthionine-direct. The genomic DNA G+C content of strain CRIBT was 28.1 mol%. On the basis of 16S rRNA gene sequence similarity, strain CRIBT was most closely related to a number of species of the genus Clostridium, including Clostridium lituseburense (97.2%), Clostridium glycolicum (96.2%), Clostridium mayombei (96.2%), Clostridium bartlettii (96.0%) and Clostridium irregulare (95.5%). All these species show very low 16S rRNA gene sequence similarity (genus Clostridium. DNA-DNA hybridization with closely related reference strains indicated reassociation values below 32%. On the basis of phenotypic and genetic studies, a novel genus, Romboutsia gen. nov., is proposed. The novel isolate CRIBT (=DSM 25109T=NIZO 4048T) is proposed as the type strain of the type species, Romboutsia ilealis gen. nov., sp. nov., of the proposed novel genus. It is proposed that C. lituseburense is transferred to this genus as Romboutsia lituseburensis comb. nov. Furthermore, the reclassification into novel genera is proposed for C. bartlettii, as Intestinibacter bartlettii gen. nov., comb. nov. (type species of the genus), C. glycolicum, as Terrisporobacter glycolicus gen. nov., comb. nov. (type species of the genus), C. mayombei, as Terrisporobacter mayombei gen. nov., comb. nov., and C. irregulare, as Asaccharospora irregularis gen. nov., comb. nov. (type species

J3Gen: A PRNG for Low-Cost Passive RFID

Directory of Open Access Journals (Sweden)

Jordi Herrera-Joancomartí

2013-03-01

Full Text Available Pseudorandom number generation (PRNG is the main security tool in low-cost passive radio-frequency identification (RFID technologies, such as EPC Gen2. We present a lightweight PRNG design for low-cost passive RFID tags, named J3Gen. J3Gen is based on a linear feedback shift register (LFSR configured with multiple feedback polynomials. The polynomials are alternated during the generation of sequences via a physical source of randomness. J3Gen successfully handles the inherent linearity of LFSR based PRNGs and satisfies the statistical requirements imposed by the EPC Gen2 standard. A hardware implementation of J3Gen is presented and evaluated with regard to different design parameters, defining the key-equivalence security and nonlinearity of the design. The results of a SPICE simulation confirm the power-consumption suitability of the proposal.

O impacto da genética na asma infantil

OpenAIRE

Pinto,Leonardo A.; Stein,Renato T.; Kabesch,Michael

2008-01-01

OBJETIVO: Apresentar os resultados dos estudos mais importantes e recentes sobre a genética da asma. Estes dados devem auxiliar os clínicos gerais a compreender o impacto da genética sobre este distúrbio complexo e como os genes e polimorfismos influenciam a asma e a atopia. FONTES DOS DADOS: Os dados foram coletados do banco de dados MEDLINE. Os estudos de associação genética foram selecionados do Genetic Association Database, um repositório de estudos de associação genética de doenças e dis...

Discusión: Explicaciones genéticas y psicológicas de la esquizofrenia.Genética de la esperanza

Directory of Open Access Journals (Sweden)

Silvio Bolaños-Salvatierra

2003-01-01

Full Text Available En este documento se rebaten críticas hechas por Raventós y Jensen al artículo “Genética y comportamiento”. Cuatro temas fueron seleccionados: 1 se determina que los antipsicóticos aparecieron veinte años después de la concepción hereditaria de la esquizofrenia; 2 se considera que la discusión es altamente pertinente, para nada bizantina o irrelevante, debido que persisten prácticas epistémicas riesgosas en los investigadores genético-conductuales; 3 aunque ninguna conducta humana está exenta de influencia constitucional, el enfoque biologicista se ha propasado al pretender explicar genéticamente casi todo, desconfirmando solapadamente la importancia de la historia personal; y, 4 se plantea que la investigación biológica sobrevalora el peso de las anomalías genéticas frente a la historia social, por lo que solo aparenta cautela. Se propone investigar genéticamente la esperanza con el objetivo de saturar a la humanidad con ese tipo de explicaciones, para alcanzar más rápido una convivencia basada en la tolerancia y el respeto.

GenExp: an interactive web-based genomic DAS client with client-side data rendering.

Directory of Open Access Journals (Sweden)

Bernat Gel Moreno

Full Text Available BACKGROUND: The Distributed Annotation System (DAS offers a standard protocol for sharing and integrating annotations on biological sequences. There are more than 1000 DAS sources available and the number is steadily increasing. Clients are an essential part of the DAS system and integrate data from several independent sources in order to create a useful representation to the user. While web-based DAS clients exist, most of them do not have direct interaction capabilities such as dragging and zooming with the mouse. RESULTS: Here we present GenExp, a web based and fully interactive visual DAS client. GenExp is a genome oriented DAS client capable of creating informative representations of genomic data zooming out from base level to complete chromosomes. It proposes a novel approach to genomic data rendering and uses the latest HTML5 web technologies to create the data representation inside the client browser. Thanks to client-side rendering most position changes do not need a network request to the server and so responses to zooming and panning are almost immediate. In GenExp it is possible to explore the genome intuitively moving it with the mouse just like geographical map applications. Additionally, in GenExp it is possible to have more than one data viewer at the same time and to save the current state of the application to revisit it later on. CONCLUSIONS: GenExp is a new interactive web-based client for DAS and addresses some of the short-comings of the existing clients. It uses client-side data rendering techniques resulting in easier genome browsing and exploration. GenExp is open source under the GPL license and it is freely available at http://gralggen.lsi.upc.edu/recerca/genexp.

A Software-Assurance Design Approach for NextGen Enabling Technologies, Phase I

Data.gov (United States)

National Aeronautics and Space Administration — The Next Generation Air Transportation System (NextGen) brings significant advancements to the current management of the National Airspace (NAS). These fundamental...

Design and Selection of Innovative Primary Circulation Pumps for GEN-IV Lead Fast Reactors

Directory of Open Access Journals (Sweden)

Walter Borreani

2017-12-01

Full Text Available Although Lead-cooled Fast Reactor (LFR is not a new concept, it continues to be an example of innovation in the nuclear field. Recently, there has been strong interest in liquid lead (Pb or liquid lead–bismuth eutectic (LBE both critical and subcritical systems in a relevant number of Countries, including studies performed in the frame of GENERATION-IV initiative. In this paper, the theoretical and computational findings for three different designs of Primary Circulation Pump (PCP evolving liquid lead (namely the jet pump, the Archimedean pump and the blade pump are presented with reference to the ALFRED (Advanced Lead Fast Reactor European Demonstrator design. The pumps are first analyzed from the theoretical point of view and then modeled with a 3D CFD code. Required design performance of the pumps are approximatively around an effective head of 2 bar with a mass flow rate of 5000 kg/s. Taking into account the geometrical constraints of the reactor and the fluid dynamics characteristics of the molten lead, the maximum design velocity for molten lead fluid flow of 2 m/s may be exceeded giving rise to unacceptable erosion phenomena of the blade or rotating component of the primary pumping system. For this reason a deep investigation of non-conventional axial pumps has been performed. The results presented shows that the design of the jet pump looks like beyond the current technological feasibility while, once the mechanical challenges of the Archimedean (screw pump and the fluid-dynamic issues of the blade pump will be addressed, both could represent viable solutions as PCP for ALFRED. Particularly, the blade pump shows the best performance in terms of pressure head generated in normal operation conditions as well as pressure drop in locked rotor conditions. Further optimizations (mainly for what the geometrical configuration is concerned are still necessary.

NextGen Avionics Roadmap Version 2.0

Science.gov (United States)

2011-09-30

Systems Analysis ( IPSA ) Division has defined multiple NextGen Operational (NGOps) Levels, projecting relative performance and risk based on differing...degrees of capability improvements, as shown in Figure 4. IPSA forecasts include the most likely performance NGOps level (i.e., NGOps 3-4), as well...in the near-term. Figures 5 through 9 de- pict the various programs and capabilities aligned with the various NGOps levels. Factors from the IPSA

NextGen Future Safety Assessment Game

Science.gov (United States)

Ancel, Ersin; Gheorghe, Adrian; Jones, Sharon Monica

2011-01-01

The successful implementation of the next generation infrastructure systems requires solid understanding of their technical, social, political and economic aspects along with their interactions. The lack of historical data that relate to the long-term planning of complex systems introduces unique challenges for decision makers and involved stakeholders which in turn result in unsustainable systems. Also, the need to understand the infrastructure at the societal level and capture the interaction between multiple stakeholders becomes important. This paper proposes a methodology in order to develop a holistic approach aiming to provide an alternative subject-matter expert (SME) elicitation and data collection method for future sociotechnical systems. The methodology is adapted to Next Generation Air Transportation System (NextGen) decision making environment in order to demonstrate the benefits of this holistic approach.

Methods and criterions for IV generation system choice

International Nuclear Information System (INIS)

Carre, F; Fiorini, G. L.

2005-01-01

The international forum of IV generation has been built up in 2000, initiated by the American Energy Department with an initial participation of nine countries (and of ten today). In a primary phase of these works, which was finished in October 2002, the forum objects were to define the list of nuclear systems conditions which could be ready to use in 2030 to make a sustainable energy development, and select previously the most promising technology to attain these purposes. This article presents, with its trumps and limits, the methodology which was used to select, starting from 120 propositions, one set of 6 systems which includes key technologies for the nuclears of the 21st century. (Authors)

Boron-bearing Influences of 9Cr-0.5Mo-2W-V-Nb Ferritic/Martensitic Steels for a SFR Fuel Cladding

International Nuclear Information System (INIS)

Baek, Jong-Hyuk; Han, Chang-Hee; Kim, Woo-Gon; Kim, Sung-Ho; Lee, Chan-Bock

2008-01-01

Currently the principal materials in a SFR (sodium-cooled fast reactor) of Gen-IV nuclear system are considering stainless steels (e.g. austenitic steels and ferritic/martensitic steels) for pressure boundary and structural applications in the primary circuit (cladding, duct, cold and hot leg piping, and pressure vessel). There are sound technical justifications for these material selections, and the adoption of these stainless steels for a wide range of nuclear and non-nuclear applications has generated much industrial technology and experience. However, there are strong incentives to develop advanced materials, especially cladding, for the Gen-IV SFR. The Gen-IV SFR is to have a considerable increase in safety and be economically competitive when compared with the conventional water reactors. To accomplish these objectives, the development of the fuel cladding material should be set forth as a premise because its integrity is directly related to those of the reactor system as well as the fuel in the Gen-IV SFR. Since last year, a R and D program was launched to develop the improved ferritic/martensitic steel for the Gen-IV SFR fuel cladding. Categories of materials considered in the program included 8 - 12% Cr ferritic/ martensitic steels. A strong recommendation was made for the development of a high strength steel equivalent to or superior to ASTM Gr.92 steel to offset the difficulties encountered with commercial available steels of the 8 - 12% Cr group. That is, since fuel cladding in the Gen-IV SFR would operate under higher temperatures than 600 .deg. C, contacting with liquid sodium, and be irradiated by neutrons to as high as 200dpa, the cladding should thus sustain both superior irradiation and temperature stabilities during an operational life. The newly developed advanced steel should overcome the severe drawback; mechanical properties, especially creep, are deteriorated at a higher temperature over 600 .deg. C. In this study, as one of the composition

45 CFR 310.40 - What requirements apply for accessing systems and records for monitoring Computerized Tribal IV-D...

Science.gov (United States)

2010-10-01

... 45 Public Welfare 2 2010-10-01 2010-10-01 false What requirements apply for accessing systems and records for monitoring Computerized Tribal IV-D Systems and Office Automation? 310.40 Section 310.40... COMPUTERIZED TRIBAL IV-D SYSTEMS AND OFFICE AUTOMATION Accountability and Monitoring Procedures for...

Best-practices guidelines for L2PSA development and applications. Volume 2 - Best practices for the Gen II PWR, Gen II BWR L2PSAs. Extension to Gen III reactors

International Nuclear Information System (INIS)

Raimond, E.; Durin, T.; Rahni, N.; Meignen, R.; Cranga, M.; Pichereau, F.; Bentaib, A.; Guigueno, Y.; Loeffler, H.; Mildenberger, O.; Lajtha, G.; Santamaria, C.S.; Dienstbier, J.; Rydl, A.; Holmberg, J.E.; Lindholm, I.; Maennistoe, I.; Pauli, E.M.; Dirksen, G.; Grindon, L.; Peers, K.; Hulqvist, G.; Parozzi, F.; Polidoro, F.; Cazzoli, E.; Vitazkova, J.; Burgazzi, L.; Oury, L.; Ngatchou, C.; Siltanen, S.; Niemela, I.; Routamo, T.; Helstroem, P.; Bassi, C.; Brinkman, H.; Seidel, A.; Schubert, B.; Wohlstein, R.; Guentay, S.; Vincon, L.

2010-01-01

The objective of this coordinated action was to develop best practice guidelines for the performance of Level 2 PSA methodologies with a view of harmonisation at EU level and to allow meaningful and practical uncertainty evaluations in a Level 2 PSA. Specific relationships with community in charge of nuclear reactor safety (utilities, safety authorities, vendors, and research or services companies) have been established in order to define the current needs in terms of guidelines for level 2 PSA development and applications. An international workshop was organised in Hamburg, with the support of VATTENFALL, in November 2008. The level 2 PSA experts from the ASAMPSA2 project partners have proposed some guidelines for the development and application of L2PSA based on their experience and on information available from international cooperation (EC Severe Accident network of Excellence - SARNET, IAEA standards, OECD-NEA publications and workshop) or open literature. The number of technical issues addressed in the guideline is very large and all are not covered with the same relevancy in the first version of the guideline. This version is submitted for external review in November 2010 by severe accident experts and PSA, especially, from SARNET and OECD-NEA members. The feedback of the external review will be dis cussed during an international open works hop planned in March 2011 and all outcomes will be taken into consideration in the final version of this guideline (June 2011). The guideline includes 3 volumes: - Volume 1 - General considerations on L2PSA. - Volume 2 - Technical recommendations for Gen II and III reactors. - Volume 3 - Specific considerations for future reactor (Gen IV). The recommendations formulated in the guideline should not be considered as 'mandatory' but should help the L2PSA developers to achieve high quality studies with limited time and resources. It may also help the L2PSA reviewers by positioning one specific study in comparison with some

Design of Radiation-Tolerant Structural Alloys for Generation IV Nuclear Energy Systems

Energy Technology Data Exchange (ETDEWEB)

Allen, T.R.; Was, G.S.; Bruemmer, S.M.; Gan, J.; Ukai, S.

2005-12-28

The objective of this program is to improve the radiation tolerance of both austenitic and ferritic-martensitic (F-M) alloys projected for use in Generation IV systems. The expected materials limitations of Generation IV components include: creep strength, dimensional stability, and corrosion/stress corrosion compatibility. The material design strategies to be tested fall into three main categories: (1) engineering grain boundaries; (2) alloying, by adding oversized elements to the matrix; and (3) microstructural/nanostructural design, such as adding matrix precipitates. These three design strategies were tested across both austenitic and ferritic-martensitic alloy classes

Genética e hanseníase

Directory of Open Access Journals (Sweden)

Bernardo Beiguelman

Full Text Available As diferentes linhas de pesquisa utilizadas para investigar a importância dos fatores hereditários humanos na determinação da resistência/suscetibilidade à infecção pelo Mycobacterium leprae foram discutidas no presente trabalho. Uma síntese dessas abordagens permitiu analisar os resultados das investigações sobre associação da hanseníase com polimorfismos genéticos, distribuição familial da hanseníase, prevalência da hanseníase e distância genética, concordância da hanseníase em gêmeos e estudos genéticos sobre a reação de Mitsuda.

Genética de la preeclampsia: una aproximación a los estudios de ligamiento genético.

Directory of Open Access Journals (Sweden)

Nora Alejandra Zuluaga

2004-06-01

Full Text Available La preeclampsia es considerada un problema de salud pública debido a su alta prevalencia. Muchas investigaciones coinciden en que su origen se relaciona con la interacción entre factores genéticos y ambientales. Por esta razón, múltiples estudios han explorado tales factores genéticos tratando de identificar regiones cromosómicas y genes candidatos cuyas variantes se relacionen con una mayor susceptibilidad a la enfermedad. Diversos estudios de asociación han identificado algunos genes de susceptibilidad a la preeclampsia, pero los resultados no se han replicado consistentemente en todas las poblaciones, quizá por su complejidad clínica y genética. El levantamiento de mapas de genes y regiones cromosómicas basado en análisis de ligamiento ha mostrado resultados interesantes con algunos marcadores en los cromosomas 2 y 4. En este sentido, hay muchas expectativas con respecto a los genes localizados en tales regiones candidatas, debido a que la identificación de los factores de riesgo genético podría ayudar al entendimiento de esta condición y en proveer claves para su prevención y tratamiento.

Divergence and genetic variability among superior rubber tree genotypes Divergência e variabilidade genética de genótipos superiores de seringueira

Directory of Open Access Journals (Sweden)

Lígia Regina Lima Gouvêa

2010-02-01

Full Text Available The objective of this work was to estimate the genetic variability and divergence among 22 superior rubber tree (Hevea sp. genotypes of the IAC 400 series. Univariate and multivariate analyses were performed using eight quantitative traits (descriptors, including yield. In the univariate analyses, the estimated parameters were: genetic and environmental variances; genetic and environmental coefficients of variation; and the variation index. The Mahalanobis generalized distance, the Tocher agglomerative method and canonical variables were used for the multivariate analyses. In the univariate analyses, variability was verified among the genotypes for all the variables evaluated. The Tocher method grouped the genotypes into 11 clusters of dissimilarity. The first four canonical variables explained 87.93% of the cumulative variation. The highest genetic variability was found in rubber yield-related traits, which contributed the most to the genetic divergence. The most divergent pairs of genotypes are suggested for crossbreeding. The genotypes evaluated are suitable for breeding and may be used to continue the IAC rubber tree breeding program.O objetivo deste trabalho foi estimar a divergência e a variabilidade genética entre 22 genótipos superiores de seringueira (Hevea sp. da série IAC 400. Análises univariadas e multivariadas foram realizadas com oito caracteres quantitativos (descritores, incluindo produtividade. Na análise univariada, os parâmetros estimados foram: variâncias genética e ambiental, coeficientes de variação genética e ambiental, e índice de variação. A distância generalizada de Mahalanobis, o método aglomerativo de Tocher e variáveis canônicas foram utilizados nas análises multivariadas. Nas análises univariadas, verificou-se variabilidade entre os genótipos para todas as variáveis avaliadas. O método de Tocher agrupou os genótipos em 11 grupos de dissimilaridade. As quatro primeiras variáveis can

Development of generation IV nuclear energy systems

International Nuclear Information System (INIS)

Matsui, Kazuaki; Oka, Yoshiaki; Ogawa, Masuro; Ichimiya, Masakazu; Noda, Hiroshi

2003-01-01

The fifth 'Generation IV International Forum (GIF), Policy Group Meetings' was held at the Zen-Nikku Hotel in Tokyo, on September 19-20, 2002, under participations of Abraham, Secretary of DOE in U.S.A., Columbani, Secretary of CEA in France, Fujiie, Chairman of CAE in Japan, Kano, Parliamental Minister of MIS in Japan, and so on. Ten nations entering GIF (Argentina, Brazil, Canada, France, Japan, Korea, South Africa, Switzerland, U.K., and U.S.A.) selected six next generation nuclear energy concepts for objects of international cooperative research and development aiming at its practice by 2030. These concepts applicable to not only power generation, but also hydrogen production, sea water purification, and so on, are sodium liquid metal cooled reactor (Japan), high temperature gas cooled reactor (France), Super-critical pressure water cooled reactor (SCWR: Canada), Lead metal cooled reactor (Switzerland), Gas cooled fast reactor (U.S.A.), and molten salts reactor. On the generation IV nuclear reactor systems aiming to further upgrade their sustainability, safety, economical efficiency, and nuclear non proliferation, the 'Plans on Technical Development' (Road-map) to decide priority of their R and Ds has been cooperatively discussed under frameworks of international research cooperation by the GIF members nations. Here were shared descriptions on nuclear fuel cycle as a remise of technical evaluation and adopted concepts by Japanese participants contributing to making up the Road-map. (G.K.)

Estructura y diversidad genética en vacas Holstein de Antioquia usando un polimorfismo del gen bGH

Directory of Open Access Journals (Sweden)

Juan Rincon F.

2013-03-01

Full Text Available Objetivo. Determinar las frecuencias alélicas y genotípicas del polimorfismo del intrón 3 del gen bGH y estimar algunos parámetros de estructura poblacional en ganado Holstein. Materiales y métodos. El estudio se realizó con 1366 vacas Holstein en 120 hatos de 11 municipios del departamento de Antioquia. Se extrajo DNA por el método de Salting out y la genotipificación se realizó usando la técnica de PCR-RFLPs. La diversidad genética se determinó mediante la comparación de las heterocigosidades, El equilibrio de Hardy-Weinberg (HW y la diferenciación genética entre las poblaciones se realizó usando el software Arlequín 2.0 Las frecuencias alélicas y genotípicas se evaluaron mediante el paquete estadístico SAS®. Resultados. Las frecuencias genotípicas encontradas fueron 0.764 (+/+, 0.223 (+/- y 0.013 (-/- y las frecuencias alélicas 0.876 (+ y 0.124 (-. No se encontraron desviaciones del Equilibrio de Hardy Weinberg en ninguna de las subpoblaciones. La diversidad genética determinada mediante la comparación de las heterocigosidades fue relativamente baja entre poblaciones pero al interior de estas no. El valor de FST de toda la población fue de 0.0068 y significativo (p<0.05, algunos FST pareados también lo fueron, tomando valores desde 0.0 a 0.13. Los estadísticos FIT y FIS no fueron significativos. Conclusiones. El gen bGH es un candidato interesante para evaluar características de importancia económica ya que no parece haber sido sometido a selección directa, presenta una variabilidad media en las poblaciones, observándose diferenciación genética significativa entre distintos municipios, producto de los diferentes sistemas de producción y acceso a las biotecnologías.

Monitoring and Fault Detection in Photovoltaic Systems Based On Inverter Measured String I-V Curves

DEFF Research Database (Denmark)

Spataru, Sergiu; Sera, Dezso; Kerekes, Tamas

2015-01-01

Most photovoltaic (PV) string inverters have the hardware capability to measure at least part of the current-voltage (I-V) characteristic curve of the PV strings connected at the input. However, this intrinsic capability of the inverters is not used, since I-V curve measurement and monitoring...... functions are not implemented in the inverter control software. In this paper, we aim to show how such a functionality can be useful for PV system monitoring purposes, to detect the presence and cause of power-loss in the PV strings, be it due to shading, degradation of the PV modules or balance......-of-system components through increased series resistance losses, or shunting of the PV modules. To achieve this, we propose and experimentally demonstrate three complementary PV system monitoring methods that make use of the I-V curve measurement capability of a commercial string inverter. The first method is suitable...

Salud pública, genética y ética

Directory of Open Access Journals (Sweden)

Kottow Miguel H

2002-01-01

Full Text Available La investigación genética ha tenido una enorme expansión en recientes décadas, con repercusiones terapéuticas aún inciertas. El análisis bioético tradicional de las complejas prácticas genéticas ha sido insuficiente por sostenerse en la ética de la investigación y en la bioética de corte principialista. Los problemas éticos más importantes de la genética son de orden colectivo y deben ser abordados por una reflexión ético-social cuyo enfoque es más amplio que la agenda interpersonal del principialismo. Temas como exploraciones genéticas, cuestiones patrimoniales, manipulación génica y asignación de recursos, deben todos ser sometidos a un pensamiento inspirado en los requerimientos de la ciudadanía, en el bien común y en la definición del rol del Estado en fiscalizar actividades genéticas y en proteger a la población. El objetivo del estudio es mostrar cómo el amplio campo de la ética y de la genética tiene una mayor relevancia en el campo social que en el clínico. El objetivo del trabajo es señalar que la bioética principialista ha enfatizado los problemas éticos individuales que nacen con la intervención genética, a costa de marginar sus importantes repercusiones sociales.

Salud pública, genética y ética

Directory of Open Access Journals (Sweden)

Miguel H Kottow

2002-10-01

Full Text Available La investigación genética ha tenido una enorme expansión en recientes décadas, con repercusiones terapéuticas aún inciertas. El análisis bioético tradicional de las complejas prácticas genéticas ha sido insuficiente por sostenerse en la ética de la investigación y en la bioética de corte principialista. Los problemas éticos más importantes de la genética son de orden colectivo y deben ser abordados por una reflexión ético-social cuyo enfoque es más amplio que la agenda interpersonal del principialismo. Temas como exploraciones genéticas, cuestiones patrimoniales, manipulación génica y asignación de recursos, deben todos ser sometidos a un pensamiento inspirado en los requerimientos de la ciudadanía, en el bien común y en la definición del rol del Estado en fiscalizar actividades genéticas y en proteger a la población. El objetivo del estudio es mostrar cómo el amplio campo de la ética y de la genética tiene una mayor relevancia en el campo social que en el clínico. El objetivo del trabajo es señalar que la bioética principialista ha enfatizado los problemas éticos individuales que nacen con la intervención genética, a costa de marginar sus importantes repercusiones sociales.

Aerodynamic performance analysis of an airborne wind turbine system with NREL Phase IV rotor

International Nuclear Information System (INIS)

Saeed, Muhammad; Kim, Man-Hoe

2017-01-01

Highlights: • Aerodynamic predictions for a buoyant airborne system at an altitude of 400 m. • Aerodynamic characteristics of NREL Phase IV rotor operating in a shell casing. • Buoyant shell aerodynamics under varying wind conditions. - Abstract: Wind energy becomes more powerful and consistent with an increase in altitude, therefore, harvesting the wind energy at high altitude results in a naturally restocked source of energy which is cheaper and far more efficient than the conventional wind power system. Airborne wind turbine (AWT), one of the many techniques being employed for this purpose, stands out due to its uninterrupted scheme of energy production. This paper presents the aerodynamic performance of AWT system with NREL Phase IV rotor at an altitude of 400 m. Unsteady simulation of the airborne system has been carried out and variations in the rotor’s torque for a complete revolution are reported and discussed. In order to compare the performance of the shell mounted configuration of Phase IV rotor with its standard test configuration, steady state simulations of the rotor are also conducted under various wind conditions for both configurations. Finally, for stable design of the buoyant airborne system, aerodynamic forces on the shell body are computed and reported.

The use of IV-tubing as a closed-suction drainage system during neurosurgical cases in Tanzania.

Science.gov (United States)

Bonfield, Christopher M; Shabani, Hamisi K; Kanumba, Emmanuel S; Ellegala, Dilantha B; Nicholas, Joyce

2013-01-01

Commercial closed-suctions drainage systems are commonly used in the United States and many other countries for use in neurosurgical cases. However, in Tanzania and other developing nations with fewer resources, these are not available. This report explores another option for a closed-system drainage system utilizing inexpensive supplies found commonly in hospitals around the world. Sterile IV-tubing is cut, inserted into the wound, and brought out through an adjacent puncture incision. For suction, an empty plastic bottle can be attached to the tubing. The IV-tubing closed-suction drainage system was applied in both cranial and spinal neurosurgical procedures, including as subdural, subgaleal, epidural, and suprafacial drains. It maintained suction and was an adequate substitute when commercial drains are unavailable. This report illustrates how sterile IV-tubing can be adapted for use as a closed-drainage system. It utilizes inexpensive supplies commonly found in many hospitals throughout the world and can be applied to both cranial and spinal neurosurgical procedures.

História da genética no Brasil: um olhar a partir do Museu da Genética da Universidade Federal do Rio Grande do Sul

Directory of Open Access Journals (Sweden)

Vanderlei Sebastiao de Souza

2013-06-01

Full Text Available Aborda o contexto de criação do Museu da Genética, em 2011 no Departamento de Genética na Universidade Federal do Rio Grande do Sul, em Porto Alegre, e apresenta sua estrutura e conteúdo. Argumenta-se que os materiais disponibilizados no Museu da Genética constituem uma rica fonte para pesquisas sobre a história da genética no Brasil (e da genética de populações humanas em particular a partir da segunda metade do século XX, tema ainda pouco investigado, apesar da proeminência dessa área do conhecimento no Brasil.

Manipulación genética de seres humanos

Directory of Open Access Journals (Sweden)

Manuel Santos Alcántara

2006-08-01

Full Text Available El gran avance que ha tenido la Genética en los últimos años y, particularmente, aquello relacionado con el desciframiento del genoma humano, ha traído a la discusión pública la posibilidad concreta de manipular genéticamente a los seres humanos. El mejoramiento o perfeccionamiento genético de los seres humanos, denominado eugenesia, actualmente se ha convertido técnicamente en una realidad, motivando una profunda reflexión de tipo ético. La pregunta básica es la siguiente: aquello que es técnicamente posible de realizar ¿es ético hacerlo? ¿Tienen derecho los padres a acceder a la tecnología genética para mejorar las características de sus hijos? En este artículo se revisan las bases científicas del mejoramiento genético de los seres humanos, y se plantean los cuestionamientos éticos más relevantes derivados de esta manipulación.

Overview of Generation IV (Gen IV) Reactor Designs - Safety and Radiological Protection Considerations. Published on September 24, 2012

International Nuclear Information System (INIS)

Couturier, Jean; Bruna, Giovanni; Baudrand, Olivier; Blanc, Daniel; Ivanov, Evgeny; Bonneville, Herve; Clement, Bernard; Kissane, Martin; Meignen, Renaud; Monhardt, Daniel; Nicaise, Gregory; Bourgois, Thierry; Hache, Georges

2012-01-01

The purpose of this document is to provide an updated overview of specific safety and radiological protection issues for all the reactor concepts adopted by the GIF (Generation IV International Forum), independent of their advantages or disadvantages in terms of resource optimization or long-lived-waste reduction. In particular, this new document attempts to bring out the advantages and disadvantages of each concept in terms of safety, taking into account the Western European Nuclear Regulators' Association (WENRA) statement concerning safety objectives for new nuclear power plants. Using an identical framework for each reactor concept (sodium-cooled fast reactors or SFR, high / very-high temperature helium-cooled reactors of V/HTR, gas-cooled fast reactors or GFR, lead-or lead / bismuth-cooled fast reactors or LFR, molten salt reactors or MSR, and supercritical-water-cooled reactors or SCWR), this summary report provides some general conclusions regarding their safety and radiological protection issues, inspired by WENRA's safety objectives and on the basis of available information. Initial lessons drawn from the events at the Fukushima-Daiichi nuclear power plant in March 2011 have also been taken into account in IRSN's analysis of each reactor concept

Programa nacional de prevención y consejería genética del retinoblastoma mediante detección de mutaciones en el gen RB.

Directory of Open Access Journals (Sweden)

H. Frayle

2001-07-01

una la doble mutación inactivante del gen Rb, exclusivamente somática en los esporádicos y germinal más somática en los hereditarios. Esta investigacin tuvo como objetivo caracterizar las mutaciones en el gen Rb mediante secuenciación directa y evaluar su utilidad en la consejería genética.

Human-Automation Cooperation for Separation Assurance in Future NextGen Environments

Science.gov (United States)

Mercer, Joey; Homola, Jeffrey; Cabrall, Christopher; Martin, Lynne; Morey, Susan; Gomez, Ashley; Prevot, Thomas

2014-01-01

A 2012 Human-In-The-Loop air traffic control simulation investigated a gradual paradigm-shift in the allocation of functions between operators and automation. Air traffic controllers staffed five adjacent high-altitude en route sectors, and during the course of a two-week experiment, worked traffic under different function-allocation approaches aligned with four increasingly mature NextGen operational environments. These NextGen time-frames ranged from near current-day operations to nearly fully-automated control, in which the ground systems automation was responsible for detecting conflicts, issuing strategic and tactical resolutions, and alerting the controller to exceptional circumstances. Results indicate that overall performance was best in the most automated NextGen environment. Safe operations were achieved in this environment for twice todays peak airspace capacity, while being rated by the controllers as highly acceptable. However, results show that sector operations were not always safe; separation violations did in fact occur. This paper will describe in detail the simulation conducted, as well discuss important results and their implications.

Synthetic and Enhanced Vision Systems for NextGen (SEVS) Simulation and Flight Test Performance Evaluation

Science.gov (United States)

Shelton, Kevin J.; Kramer, Lynda J.; Ellis,Kyle K.; Rehfeld, Sherri A.

2012-01-01

The Synthetic and Enhanced Vision Systems for NextGen (SEVS) simulation and flight tests are jointly sponsored by NASA's Aviation Safety Program, Vehicle Systems Safety Technology project and the Federal Aviation Administration (FAA). The flight tests were conducted by a team of Honeywell, Gulfstream Aerospace Corporation and NASA personnel with the goal of obtaining pilot-in-the-loop test data for flight validation, verification, and demonstration of selected SEVS operational and system-level performance capabilities. Nine test flights (38 flight hours) were conducted over the summer and fall of 2011. The evaluations were flown in Gulfstream.s G450 flight test aircraft outfitted with the SEVS technology under very low visibility instrument meteorological conditions. Evaluation pilots flew 108 approaches in low visibility weather conditions (600 ft to 2400 ft visibility) into various airports from Louisiana to Maine. In-situ flight performance and subjective workload and acceptability data were collected in collaboration with ground simulation studies at LaRC.s Research Flight Deck simulator.

Estudo do polimorfismo genético no gene p53 (códon 72 em câncer colorretal Role of the genetic polymorphism of p53 (codon 72 gene in colorectal cancer

Directory of Open Access Journals (Sweden)

Jacqueline Miranda de Lima

2006-03-01

Full Text Available RACIONAL: Polimorfismos genéticos são variações genéticas que podem ocorrer em seqüências codificadoras e não-codificadoras, levando a alterações qualitativas e/ou quantitativas das proteínas em questão. O p53 é o gene mais comumente alterado no câncer humano. O polimorfismo desse gene no códon 72 ocorre por substituição de uma base e tem sido associado a maior risco de câncer. OBJETIVO: Determinar a possível associação entre o polimorfismo no códon 72 (72 arginina/prolina do gene p53 e câncer colorretal. CASUÍSTICA E MÉTODOS: Foram avaliados em 100 pacientes com câncer colorretal e em 100 indivíduos sem câncer, pareados quanto ao sexo idade, o hábito de fumar, o etilismo e no grupo caso o estádio, o grau de diferenciação e a evolução da doença. O genótipo (72 arginina/prolina foi determinado por PCR, utilizando-se primers (seqüências de nucleotídeos específicos. RESULTADOS: O genótipo homozigoto arginina/arginina foi prevalente em 56% no grupo controle e em 58% no grupo caso. Não se observou diferença entre os dois grupos. No estádio IV este genótipo foi mais freqüente quando comparado ao estádio I (80% versus 14%. Não se observou diferença entre as variações do genótipo e fumo, álcool, evolução clínica ou grau de diferenciação. CONCLUSÃO: A prevalência do genótipo arginina/arginina foi a mais freqüente nos dois grupos. Não foi encontrada correlação entre maior risco de câncer e o polimorfismo no códon 72 prolina/arginina do gene p53. Apesar do pequeno número de doentes com câncer em estádio avançado (IV, estes tiveram maior prevalência do genótipo arginina/arginina.BACKGROUND: Polymorphisms are genetic variations that can occur in sequences of codons, leading to defective proteins. p53 is the most commonly gene affected in human cancer. The polymorphism of this gene occurs by a substitution of a base in codon 72 and may increase the risk of cancer. AIM: To investigate the

Programa nacional de prevención y consejería genética del retinoblastoma mediante detección de mutaciones en el gen rb.

OpenAIRE

Frayle, H.; Guevara, G.

2011-01-01

El retinoblastoma es un raro tumor ocular que se diagnostica en los niños, 40% de los casos se consideran hereditarios y 60% esporádicos. El modelo genético propuesto por Knudson involucra
una la doble mutación inactivante del gen Rb, exclusivamente somática en los esporádicos y germinal más somática en los hereditarios. Esta investigacin tuvo como objetivo caracterizar las mutaciones en el gen Rb mediante secuenciación directa y evaluar su utilidad en la consejería genética....

Surface Map Traffic Intent Displays and Net-Centric Data-link Communications for NextGen

Science.gov (United States)

Shelton, Kevin J.; Prinzel, Lawrence J., III; Jones, Denise R.; Allamandola, Angela S.; Arthur, Jarvis J., III; Bailey, Randall E.

2009-01-01

By 2025, U.S. air traffic is predicted to increase three fold and may strain the current air traffic management system, which may not be able to accommodate this growth. In response to this challenge, a revolutionary new concept has been proposed for U.S. aviation operations, termed the Next Generation Air Transportation System or "NextGen". Many key capabilities are being identified to enable NextGen, including the use of data-link communications. Because NextGen represents a radically different approach to air traffic management and requires a dramatic shift in the tasks, roles, and responsibilities for the flight deck, there are numerous research issues and challenges that must be overcome to ensure a safe, sustainable air transportation system. Flight deck display and crew-vehicle interaction concepts are being developed that proactively investigate and overcome potential technology and safety barriers that might otherwise constrain the full realization of NextGen. The paper describes simulation research, conducted at National Aeronautics and Space Administration (NASA) Langley Research Center, examining data-link communications and traffic intent data during envisioned four-dimensional trajectory (4DT)-based and equivalent visual (EV) surface operations. Overall, the results suggest that controller pilot data-link communications (CPDLC) with the use of mandatory pilot read-back of all clearances significantly enhanced situation awareness for 4DT and EV surface operations. The depiction of graphical traffic state and intent information on the surface map display further enhanced off-nominal detection and pilot qualitative reports of safety and awareness.

Airspace Systems Program: Next Generation Air Transportation System, NextGen Systems Analysis, Integration and Evaluation Project. Version 1.0; Project Plan

Science.gov (United States)

Quon, Leighton

2010-01-01

The key objectives of the NASA ASP are to: Improve mobility, capacity efficiency and access of the airspace system. Improve collaboration, predictability, and flexibility for the airspace users. Enable accurate modeling and simulation of air transportation systems. Accommodate operations of all classes of aircraft. Maintain system safety and environmental protection. In support of these program objectives, the major goal of the NextGen-SAIE Project is to enable the transition of key capacity and efficiency improvements to the NAS. Since many aspects of the NAS are unique to specific airport or airspace environments, demand on various parts of the NAS is not expected to increase equally as system demand grows. SAIE will provide systems level analysis of the NAS characteristics, constraints, and demands such that a suite of capacity-increasing concepts and technologies for system solutions are enabled and facilitated. The technical objectives in support of this goal are the following: Integration, evaluation, and transition of more mature concepts and technologies in an environment that faithfully emulates real-world complexities. Interoperability research and analysis of ASP technologies across ATM functions is performed to facilitate integration and take ASP concepts and technologies to higher Technology Readiness Level (TRL). Analyses are conducted on the program s concepts to identify the system benefits or impacts. System level analysis is conducted to increase understanding of the characteristics and constraints of airspace system and its domains.

Generation IV nuclear energy systems: road map and concepts. 2. Generation II Measurement Systems for Generation IV Nuclear Power Plants

International Nuclear Information System (INIS)

Miller, Don W.

2001-01-01

need for substantial research. As we consider I and C systems in Generation IV reactors, we have the opportunity to take a much less 'timid' design philosophy than was taken in the design of I and C systems in the ALWRs. We need to make use of advanced technology to design an I and C system for the Generation IV multi-unit plant designs currently being considered. Such a design should accomplish the following: 1. provides for multi-unit control; 2. contributes to a plant design objective of a very low core damage frequency; 3. maximizes plant thermal efficiency (>50%); 4. maximizes plant capacity factor (>90%); 5. optimizes operability; 6. maximizes maintainability; 7. provides for on-line monitoring, calibration, and diagnostics; 8. provides optimum response to disturbances; 9. provides excellent load-following capability. When we consider the current situation in operating Generation I and II nuclear power plants and even Generation III ALWR design, we conclude that Generation IV reactors should employ at least Generation II measurement systems. Let us first consider data transmission, which is a form of communication, and ask the question: Do new communication-transferring methods by electrons flow in copper wires? The obvious answer is no. Virtually all new communication systems are using some electromagnetic method, such as light, microwaves, HF or VHF radio signals, and virtually no copper wires. When we envision Generation IV nuclear power plants, we should minimize the use of copper wires for data transmission. We should transmit data primarily by fiber optics and various wireless methods, some of which can penetrate thick barriers. Now let us consider sensors. If we use light for data transmission, then we should also use optical-based sensors. We should also take advantage of microprocessors, which provide opportunities to embed 'intelligence' in the sensor that can be used to increase accuracy, stability, and tolerance to external stressors (i.e., radiation

Justicia en salud y genética

Directory of Open Access Journals (Sweden)

Maria Graciela De Ortuzar

2014-06-01

Full Text Available Las expectativas puestas en el conocimiento genético exceden el ámbito de la medicina tradiciona, debido a que la intervención directa en la lotería natural demandaría el replanteamiento de conceptos centrales de justicia en salud: necesidades médicas, enfermedad, normalidad, e igualdad de oportunidades en el acceso a la salud. El punto en debate es sí el replanteo de dichos conceptos conlleva un cambio radical en las teorías de justicia (libertariana y/o liberal, mostrando su obsolescencia, o sí simplemente se requiere ampliar dichos conceptos claves por fallas estructurales en las mismas teorías. Como hipótesis general considero que los supuestos cuestionamientos, lejos de socavar las bases de las teorías de justicia, sólo ponen en evidencia sus viejos problemas estructurales. Por razones expositivas, dividiré la presentación tres partes. En la Primera parte, analizo la teoría libertariana, estudiando las contradicciones del modelo a través del impacto de la información genética en el seguro privado de salud. En la Segunda Parte, desarrollo la propuesta alternativa liberal rawlsianadanielsiana del modelo de seguro público, evaluando las implicaciones de la genética a partir de la crítica de su concepto biológico de enfermedad y su restricción al acceso a la salud por necesidades naturales. En la Tercera parte presento un modelo integral de necesidades y capacidades básicas, comprendiendo la prevención, el tratamiento y el mejoramiento moralmente permisible (genético y no genético.Mi aporte principal consiste en la elaboración de este modelo normativo integral de necesidades y capacidades para la regulación conjunta de la información y terapia genética con los restantes problemas de salud.

Multi-scale approach to the modeling of fission gas discharge during hypothetical loss-of-flow accident in gen-IV sodium fast reactor

Energy Technology Data Exchange (ETDEWEB)

Behafarid, F.; Shaver, D. R. [Rensselaer Polytechnic Inst., Troy, NY (United States); Bolotnov, I. A. [North Carolina State Univ., Raleigh, NC (United States); Jansen, K. E. [Univ. of Colorado, Boulder, CO (United States); Antal, S. P.; Podowski, M. Z. [Rensselaer Polytechnic Inst., Troy, NY (United States)

2012-07-01

The required technological and safety standards for future Gen IV Reactors can only be achieved if advanced simulation capabilities become available, which combine high performance computing with the necessary level of modeling detail and high accuracy of predictions. The purpose of this paper is to present new results of multi-scale three-dimensional (3D) simulations of the inter-related phenomena, which occur as a result of fuel element heat-up and cladding failure, including the injection of a jet of gaseous fission products into a partially blocked Sodium Fast Reactor (SFR) coolant channel, and gas/molten sodium transport along the coolant channels. The computational approach to the analysis of the overall accident scenario is based on using two different inter-communicating computational multiphase fluid dynamics (CMFD) codes: a CFD code, PHASTA, and a RANS code, NPHASE-CMFD. Using the geometry and time history of cladding failure and the gas injection rate, direct numerical simulations (DNS), combined with the Level Set method, of two-phase turbulent flow have been performed by the PHASTA code. The model allows one to track the evolution of gas/liquid interfaces at a centimeter scale. The simulated phenomena include the formation and breakup of the jet of fission products injected into the liquid sodium coolant. The PHASTA outflow has been averaged over time to obtain mean phasic velocities and volumetric concentrations, as well as the liquid turbulent kinetic energy and turbulence dissipation rate, all of which have served as the input to the core-scale simulations using the NPHASE-CMFD code. A sliding window time averaging has been used to capture mean flow parameters for transient cases. The results presented in the paper include testing and validation of the proposed models, as well the predictions of fission-gas/liquid-sodium transport along a multi-rod fuel assembly of SFR during a partial loss-of-flow accident. (authors)

Gen2 RFID-Based System Framework for Resource Circulation in Closed-Loop Supply Chains

Directory of Open Access Journals (Sweden)

Young-woo Kim

2017-10-01

Full Text Available Product recycling has become a mandatory activity under extended producer responsibility. Therefore, it is important to operate a closed-loop supply chain that integrates sourcing, production, delivery, and recycling to achieve not only environmental sustainability, but also economic benefits. However, this goal is affected by chronic problems caused by uncertainties relating to the return timing, quantity, and quality of returned items. Many studies proved that information visibility could solve these problems. In this context, a system framework for closed-loop supply chain management is proposed that gathers real-time information within a supply chain and product lifecycle by using the Internet-of-Things, including radio frequency identification (RFID. Specifically, the most recent Gen2 RFID protocol, which provides new features to create new positive effects, is considered. Additionally, an information system is designed, including RFID tag encoding, which supports the operation of the proposed system. Finally, the lifecycle benefits are examined, such as counterfeit prevention, real-time monitoring and maintenance in the middle-of-life phase, and reverse process streamlining. The ultimate aim is to design a system that facilitates the profitable and environmentally friendly operation of the closed-loop supply chain.

Identification of Anaplasma marginale type IV secretion system effector proteins.

Directory of Open Access Journals (Sweden)

Svetlana Lockwood

Full Text Available Anaplasma marginale, an obligate intracellular alphaproteobacterium in the order Rickettsiales, is a tick-borne pathogen and the leading cause of anaplasmosis in cattle worldwide. Complete genome sequencing of A. marginale revealed that it has a type IV secretion system (T4SS. The T4SS is one of seven known types of secretion systems utilized by bacteria, with the type III and IV secretion systems particularly prevalent among pathogenic Gram-negative bacteria. The T4SS is predicted to play an important role in the invasion and pathogenesis of A. marginale by translocating effector proteins across its membrane into eukaryotic target cells. However, T4SS effector proteins have not been identified and tested in the laboratory until now.By combining computational methods with phylogenetic analysis and sequence identity searches, we identified a subset of potential T4SS effectors in A. marginale strain St. Maries and chose six for laboratory testing. Four (AM185, AM470, AM705 [AnkA], and AM1141 of these six proteins were translocated in a T4SS-dependent manner using Legionella pneumophila as a reporter system.The algorithm employed to find T4SS effector proteins in A. marginale identified four such proteins that were verified by laboratory testing. L. pneumophila was shown to work as a model system for A. marginale and thus can be used as a screening tool for A. marginale effector proteins. The first T4SS effector proteins for A. marginale have been identified in this work.

45 CFR 310.35 - Under what circumstances would emergency FFP be available for Computerized Tribal IV-D Systems?

Science.gov (United States)

2010-10-01

... 45 Public Welfare 2 2010-10-01 2010-10-01 false Under what circumstances would emergency FFP be... AND OFFICE AUTOMATION Funding for Computerized Tribal IV-D Systems and Office Automation § 310.35 Under what circumstances would emergency FFP be available for Computerized Tribal IV-D Systems? (a...

International Conference on NextGen Electronic Technologies

CERN Document Server

Thalmann, Nadia; Bhaaskaran, V

2017-01-01

This book is a collection of keynote lectures from international experts presented at International Conference on NextGen Electronic Technologies (ICNETS2-2016). ICNETS2 encompasses six symposia covering all aspects of electronics and communications domains, including relevant nano/micro materials and devices . This volume comprises of recent research in areas like computational signal processing analysis, intelligent embedded systems, nanoelectronic materials and devices, optical and microwave technologies, VLSI design: circuits systems and application, and wireless communication networks, and the internet of things. The contents of this book will be useful to researchers, professionals, and students working in the core areas of electronics and their applications, especially to signal processing, embedded systems, and networking.

Algoritmos para genómica comparativa

OpenAIRE

Figueiras, Vasco da Rocha

2010-01-01

Com o surgimento da Genómica e da Proteómica, a Bioinformática conduziu a alguns dos avanços científicos mais relevantes do século XX. A Unidade de Investigação e Desenvolvimento do Biocant, parque biotecnológico de Cantanhede, assume actualmente o papel de motor no desenvolvimento da Genómica. O Biocant possui um importante sequenciador de larga escala que permite armazenar um elevado número de genomas, nomeadamente, genomas de bactérias. O estudo proposto reflecte a necessidade do Bio...

IV&V Project Assessment Process Validation

Science.gov (United States)

Driskell, Stephen

2012-01-01

The Space Launch System (SLS) will launch NASA's Multi-Purpose Crew Vehicle (MPCV). This launch vehicle will provide American launch capability for human exploration and travelling beyond Earth orbit. SLS is designed to be flexible for crew or cargo missions. The first test flight is scheduled for December 2017. The SLS SRR/SDR provided insight into the project development life cycle. NASA IV&V ran the standard Risk Based Assessment and Portfolio Based Risk Assessment to identify analysis tasking for the SLS program. This presentation examines the SLS System Requirements Review/System Definition Review (SRR/SDR), IV&V findings for IV&V process validation correlation to/from the selected IV&V tasking and capabilities. It also provides a reusable IEEE 1012 scorecard for programmatic completeness across the software development life cycle.

Medicamentos genéricos y de marca-Calidad e intercambiabilidad

Directory of Open Access Journals (Sweden)

Rua F.

2012-03-01

Full Text Available El interés por los medicamentos genéricos procede de la necesidad de los sistemas sanitarios de reducir la factura sanitaria sin merma de los objetivos de salud. Su expansión y uso requieren la aceptación de la población y de los profesionales. También requieren que se despejen algunas dudas sobre su verdadera equivalencia respecto a los medicamentos originales. Desde su introducción en el mercado farmacéutico existe el debate de si son correctamente investigados y de alta calidad. No son infrecuentes los conceptos equivocados entre los profesionales sobre los genéricos, en especial, el supuesto hecho de que pueden llegar a contener hasta un 20% menos de concentración en principio activo. Estas creencias erróneas sugieren una situación de desventaja en la eficacia y la tolerabilidad de los medicamentos genéricos comparados con sus equivalentes de marca, disminuyendo la credibilidad de los mismos. Así, en una encuesta realizada en 2008 los farmacéuticos opinaron que los genéricos y las marcas son diferentes en eficacia (26%, equivalencia (28% y, sobre todo, en la calidad del excipiente (46%, aumentando la percepción de que los genéricos son diferentes en función del laboratorio que los fabrica (52,8%. En este artículo, con el fin de ampliar los conocimientos sobre medicamentos genéricos, solucionar dudas y proporcionar información, objetiva, clara y rigurosa, se revisan los posibles prejuicios sobre genéricos y se exponen las evidencias que existen en torno a los mismos, como los requisitos de bioequivalencia de los productos genéricos, analizando si ésta corrobora adecuadamente la equivalencia terapéutica y de intercambio.

Sobre el significado del descubrimiento del gen FOXP2

OpenAIRE

Longa Martínez, Víctor Manuel

2006-01-01

El reciente descubrimiento del gen FOXP2 ha ofrecido la primera evidencia clara de la base genética del lenguaje, mostrando una correlación inequívoca desde la perspectiva genética entre una versión mutada de F0XP2 y los trastornos lingüísticos de diferente tipo sufridos por una familia inglesa, conocida como KE. El objetivo central del presente trabajo es discutir diferentes aspectos relacionados con tal descubrimiento; especialmente, la discusión del significado de FOXP2 con ...

Potencial de vida útil pós-colheita de quatro genótipos de melão tipo Galia Potential of postharvest shelf life of four genotypes of Galia type melons

Directory of Open Access Journals (Sweden)

Patrícia Lígia Dantas de Morais

2004-12-01

Full Text Available Avaliou-se o potencial de vida útil pós-colheita de melões (Cucumis melo L. tipo Galia (genótipos Primal, Solarking, Total e Vicar. Utilizou-se o delineamento inteiramente casualizado em esquema fatorial 4 (genótipos x 4 (tempos de armazenamento: 0, 3, 6 e 9 dias, com três repetições. Os frutos foram colhidos no estádio de maturação IV (predominantemente amarelo e armazenados à temperatura de 20 ± 1ºC e umidade relativa de 50 ± 2%. O genótipo Solarking apresentou uma firmeza média de polpa superior aos demais, do inicio ao final do período de armazenamento. Em todos os genótipos, os valores de sólidos solúveis no início do armazenamento encontraram-se dentro da faixa aceitável para comercialização no mercado externo, havendo pouca variação com o decorrer do período de armazenamento. A aparência interna limitou o tempo de vida útil pós-colheita do genótipo Total em apenas seis dias. Os genótipos Solarking, Vicar e Primal apresentaram maior potencial na conservação pós-colheita, principalmente o híbrido Solarking, que chegou aos nove dias de armazenamento com boa aparência interna.The postharvest life span of Galia (genotypes Primal, Solarking, Total, and Vicar melons (Cucumis melo L. was evaluated by a four (genotypes x four (storage periods: 0, 3, 6, and 9 days factorial experiment, in a completely randomized design with three replications. The fruits were harvested at maturation stage IV (yellow color predominance, and stored under 20 ± 1ºC and HR 50 ± 2%. Solarking's average firmness was better than that of the other genotypes during the experimental period. At the beginning of the experiment all genotypes had soluble solids contents at the level (eight to ten percent required for exportation, with these levels varying slightly during storage. The internal aspect limited to six days the postharvest life span of genotype Total. Solarking, Vicar, and Primal showed great postharvest conservation potential

Distributed Generation Market Demand Model (dGen): Documentation

Energy Technology Data Exchange (ETDEWEB)

Sigrin, Benjamin [National Renewable Energy Lab. (NREL), Golden, CO (United States); Gleason, Michael [National Renewable Energy Lab. (NREL), Golden, CO (United States); Preus, Robert [National Renewable Energy Lab. (NREL), Golden, CO (United States); Baring-Gould, Ian [National Renewable Energy Lab. (NREL), Golden, CO (United States); Margolis, Robert [National Renewable Energy Lab. (NREL), Golden, CO (United States)

2016-02-01

The Distributed Generation Market Demand model (dGen) is a geospatially rich, bottom-up, market-penetration model that simulates the potential adoption of distributed energy resources (DERs) for residential, commercial, and industrial entities in the continental United States through 2050. The National Renewable Energy Laboratory (NREL) developed dGen to analyze the key factors that will affect future market demand for distributed solar, wind, storage, and other DER technologies in the United States. The new model builds off, extends, and replaces NREL's SolarDS model (Denholm et al. 2009a), which simulates the market penetration of distributed PV only. Unlike the SolarDS model, dGen can model various DER technologies under one platform--it currently can simulate the adoption of distributed solar (the dSolar module) and distributed wind (the dWind module) and link with the ReEDS capacity expansion model (Appendix C). The underlying algorithms and datasets in dGen, which improve the representation of customer decision making as well as the spatial resolution of analyses (Figure ES-1), also are improvements over SolarDS.

Revision of Corallinaceae (Corallinales, Rhodophyta): recognizing Dawsoniolithon gen. nov., Parvicellularium gen. nov. and Chamberlainoideae subfam. nov. containing Chamberlainium gen. nov. and Pneophyllum.

Science.gov (United States)

Caragnano, Annalisa; Foetisch, Alexandra; Maneveldt, Gavin W; Millet, Laurent; Liu, Li-Chia; Lin, Showe-Mei; Rodondi, Graziella; Payri, Claude E

2018-03-25

A multi-gene (SSU, LSU, psbA and COI) molecular phylogeny of the family Corallinaceae (excluding the subfamilies Lithophylloideae and Corallinoideae) showed a paraphyletic grouping of six monophyletic clades. Pneophyllum and Spongites were reassessed and recircumscribed using DNA sequence data integrated with morpho-anatomical comparisons of type material and recently collected specimens. We propose Chamberlainoideae subfam. nov., including the type genus Chamberlainium gen. nov., with C. tumidum comb. nov. as the generitype, and Pneophyllum. Chamberlainium is established to include several taxa previously ascribed to Spongites, the generitype of which currently resides in Neogoniolithoideae. Additionally we propose two new genera, Dawsoniolithon gen. nov. (Metagoniolithoideae), with D. conicum comb. nov. as the generitype and Parvicellularium gen. nov. (subfamily incertae sedis), with P. leonardi sp. nov. as the generitype. Chamberlainoideae has no diagnostic morpho-anatomical features that enable one to assign specimens to it without DNA sequence data, and it is the first subfamily to possess both Type 1 (Chamberlainium) and Type 2 (Pneophyllum) tetra/bisporangial conceptacle roof development. Two characters distinguish Chamberlainium from Spongites: tetra/biasporangial conceptacle chamber diameter (300 μm in Spongites) and tetra/bisporangial conceptacle roof thickness (8 cells in Spongites). Two characters also distinguish Pneophyllum from Dawsoniolithon: tetra/bisporangial conceptacle roof thickness (8 cells in Dawsoniolithon) and thallus construction (dimerous in Pneophyllum vs. monomerous in Dawsoniolithon). This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

MODERATE C IV ABSORBER SYSTEMS REQUIRE 10{sup 12} M{sub Sun} DARK MATTER HALOS AT z {approx} 2.3: A CROSS-CORRELATION STUDY OF C IV ABSORBER SYSTEMS AND QUASARS IN SDSS-III BOSS DR9

Energy Technology Data Exchange (ETDEWEB)

Vikas, Shailendra; Wood-Vasey, W. Michael [Pittsburgh Particle Physics, Astrophysics, and Cosmology Center (PITT PACC), Department of Physics and Astronomy, University of Pittsburgh, Pittsburgh, PA 15260 (United States); Lundgren, Britt [Department of Physics, Yale University, New Haven, CT 06511 (United States); Ross, Nicholas P. [Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 92420 (United States); Myers, Adam D. [Department of Physics and Astronomy, University of Wyoming, Laramie, WY 82071 (United States); AlSayyad, Yusra [Department of Astronomy, University of Washington, Seattle, WA 98195 (United States); York, Donald G. [Department of Astronomy, University of Chicago, 5640 S. Ellis Ave, Chicago, IL 60637 (United States); Schneider, Donald P. [Department of Astronomy and Astrophysics, Pennsylvania State University, University Park, PA 16802 (United States); Brinkmann, J.; Bizyaev, Dmitry; Brewington, Howard; Malanushenko, Elena; Malanushenko, Viktor; Oravetz, Daniel; Pan, Kaike; Snedden, Stephanie [Apache Point Observatory, P.O. Box 59, Sunspot, NM 88349-0059 (United States); Ge, Jian [Department of Astronomy, University of Florida, Gainesville, FL 32611 (United States); Muna, Demitri [Center for Cosmology and Particle Physics, New York University, New York, NY 10003 (United States); Paris, Isabelle; Petitjean, Patrick, E-mail: skv4@pitt.edu [UPMC-CNRS, UMR7095, Institut d' Astrophysique de Paris, F-75014 Paris (France); and others

2013-05-01

We measure the two-point cross-correlation function of C IV absorber systems and quasars, using spectroscopic data from the Sloan Digital Sky Survey III Baryon Oscillation Spectroscopic Survey (BOSS; Data Release 9). The 19,701 quasars and 6149 C IV ''moderate'' absorbers, 0.28 A < rest-frame equivalent width (EW) < 5 A, in our study cover a redshift range of 2.1 < z < 2.5 over 3300 deg{sup 2} and represent a factor of two increase in sample size over previous investigations. We find a correlation scale length and slope of the redshift-space cross-correlation function of s{sub 0} = 8.46 {+-} 1.24 Mpc, {gamma} = 1.68 {+-} 0.19, in the redshift-space range 10 < s < 100 Mpc. We find a projected cross-correlation function of C IV absorption systems and quasars of r{sub 0} = 7.76 {+-} 2.80 Mpc, {gamma} = 1.74 {+-} 0.21. We measure the combined quasar and C IV bias to be b{sub QSO} b{sub C{sub IV}} = 8.81 {+-} 2.28. Using an estimate of b{sub QSO} from the quasar auto-correlation function we find b{sub CIV} = 2.38 {+-} 0.62. This b{sub CIV} implies that EW > 0.28 A C IV absorbers at z {approx} 2.3 are typically found in dark matter halos that have masses {>=}10{sup 11.3}-10{sup 13.4} M{sub Sun} at that redshift. The complete BOSS sample will triple the number of both quasars and absorption systems and increase the power of this cross-correlation measurement by a factor of two.

A Qualitative Assessment Of Diversion Scenarios For A Example Sodium Fast Reactor Using The Gen IV PR And PP Methodology

International Nuclear Information System (INIS)

Zentner, Michael D.

2008-01-01

A working group was created in 2002 by the Generation IV International Forum (GIF) for the purpose of developing an internationally accepted methodology for assessing the Proliferation Resistance of a nuclear energy system (NES) and its individual elements. A two year case study is being performed by the experts group using this methodology to assess the proliferation resistance of a hypothetical NES called the Example Sodium Fast Reactor (ESFR). This work demonstrates how the PR and PP methodology can be used to provide important information at various levels of details to NES designers, safeguard administrators and decision makers. The study analyzes the response of the complete ESFR nuclear energy system to different proliferation and theft strategies. The challenges considered include concealed diversion, concealed misuse and 'break out' strategies. This paper describes the work done in performing a qualitative assessment of concealed diversion scenarios from the ESFR.

Biometria e armazenamento de sementes de genótipos de cacaueiro

Directory of Open Access Journals (Sweden)

Lucimara Ribeiro Venial

2017-03-01

Full Text Available Genótipos de Theobroma cacao L. devem ser melhor estudados, para se identificar aqueles que produzem sementes mais desenvolvidas e viáveis após o armazenamento. Objetivou-se com este trabalho estudar a biometria e dois tempos de armazenamento de sementes de genótipos de cacaueiro. A biometria foi avaliada em oito genótipos de cacaueiro (tratamentos. Foram instalados testes de germinação em delineamento inteiramente ao acaso, no esquema fatorial 8 x 2 (genótipos: CCN51, PH16, CEPEC2002, Ipiranga, SJ02, PS1319, TSH1188 e Comum x dois períodos de armazenamento: 0 e dois dias. O genótipo TSH1188 apresentou maior comprimento, relação comprimento/largura, espessura e massa de 100 sementes. A absorção de água das sementes recém-colhidas dos genótipos é lenta, justificada pelos altos teores de água, o que não caracteriza padrão-trifásico. Os teores de água reduziram em média 2,3 vezes nas sementes armazenadas em relação às recém-colhidas. A germinação das sementes recém-colhidas dos genótipos foi de 100%. Após o armazenamento, as sementes do PS1319 apresentaram a menor redução da germinação (39%, enquanto as dos PH16, CEPEC2002 e SJ02 reduziram 96%. A velocidade de germinação foi maior e o tempo médio menor que dois dias nas sementes recém-colhidas do PS1319, indicando serem mais tolerante à dessecação. Sugere-se o uso dos genótipos TSH1188 e PS1319 em programas de melhoramento genético.

Enfermedades genéticas más frecuentes en pacientes atendidos en consulta de genética clínica

Directory of Open Access Journals (Sweden)

Elibett Carcasés Carcasés

2015-02-01

Full Text Available La estimación de la prevalencia de las enfermedades genéticas se dificulta, entre otras causas, por su rareza. Se realizó un estudio descriptivo retrospectivo, para identificar las enfermedades genéticas de mayor prevalencia en pacientes atendidos por este programa en el Centro Provincial de Genética Médica de Las Tunas, Cuba; desde el año 1989 hasta julio de 2014. Se revisaron todas las historias clínicas. Predominó el origen monogénico (69 %, siendo los síndromes dismórficos los más numerosos y diversos, entre ellos los neurocutáneos, que representaron el 35 %. La enfermedad genética monogénica con mayor número de casos fue la Neurofibromatosis I con el 14,4 % y el 22,2 % de las enfermedades eran de origen monogénico y dismórfico. La Trisomía 21 representó el 77 % de la causa cromosómica. En el origen multifactorial prevalecieron los defectos congénitos mayores, entre ellos los defectos reductivos de miembros (27 %

Wien Automatic System Planning (WASP) Package. A computer code for power generating system expansion planning. Version WASP-IV. User's manual

International Nuclear Information System (INIS)

2001-01-01

As a continuation of its efforts to provide methodologies and tools to Member States to carry out comparative assessment and analyse priority environmental issues related to the development of the electric power sector, the IAEA has completed a new version of the Wien Automatic System Planning (WASP) Package WASP-IV for carrying out power generation expansion planning taking into consideration fuel availability and environmental constraints. This manual constitutes a part of this work and aims to provide users with a guide to use effectively the new version of the model WASP-IV. WASP was originally developed in 1972 by the Tennessee Valley Authority and the Oak Ridge National Laboratory in the USA to meet the IAEA needs to analyse the economic competitiveness of nuclear power in comparison to other generation expansion alternatives for supplying the future electricity requirements of a country or region. Previous versions of the model were used by Member States in many national and regional studies to analyse the electric power system expansion planning and the role of nuclear energy in particular. Experience gained from its application allowed development of WASP into a very comprehensive planning tool for electric power system expansion analysis. New, improved versions were developed, which took into consideration the needs expressed by the users of the programme in order to address important emerging issues being faced by the electric system planners. In 1979, WASP-IV was released and soon after became an indispensable tool in many Member States for generation expansion planning. The WASP-IV version was continually upgraded and the development of version WASP-III Plus commenced in 1992. By 1995, WASP-III Plus was completed, which followed closely the methodology of the WASP-III but incorporated new features. In order to meet the needs of electricity planners and following the recommendations of the Helsinki symposium, development of a new version of WASP was

Coupled CFD - system-code simulation of a gas cooled reactor

International Nuclear Information System (INIS)

Yan, Yizhou; Rizwan-uddin

2011-01-01

A generic coupled CFD - system-code thermal hydraulic simulation approach was developed based on FLUENT and RELAP-3D, and applied to LWRs. The flexibility of the coupling methodology enables its application to advanced nuclear energy systems. Gas Turbine - Modular Helium Reactor (GT-MHR) is a Gen IV reactor design which can benefit from this innovative coupled simulation approach. Mixing in the lower plenum of the GT-MHR is investigated here using the CFD - system-code coupled simulation tool. Results of coupled simulations are presented and discussed. The potential of the coupled CFD - system-code approach for next generation of nuclear power plants is demonstrated. (author)

Next-Gen³: Sequencing, Modeling, and Advanced Biofuels - Final Technical Report

Energy Technology Data Exchange (ETDEWEB)

Zengler, Karsten [Univ. of California, San Diego, CA (United States). Dept. of Pediatrics; Palsson, Bernhard [Univ. of California, San Diego, CA (United States). Dept. of Bioengineering; Lewis, Nathan [Univ. of California, San Diego, CA (United States). Dept. of Pediatrics

2017-12-27

Successful, scalable implementation of biofuels is dependent on the efficient and near complete utilization of diverse biomass sources. One approach is to utilize the large recalcitrant biomass fraction (or any organic waste stream) through the thermochemical conversion of organic compounds to syngas, a mixture of carbon monoxide (CO), carbon dioxide (CO₂), and hydrogen (H₂), which can subsequently be metabolized by acetogenic microorganisms to produce next-gen biofuels. The goal of this proposal was to advance the development of the acetogen Clostridium ljungdahlii as a chassis organism for next-gen biofuel production from cheap, renewable sources and to detail the interconnectivity of metabolism, energy conservation, and regulation of acetogens using next-gen sequencing and next-gen modeling. To achieve this goal we determined optimization of carbon and energy utilization through differential translational efficiency in C. ljungdahlii. Furthermore, we reconstructed a next-generation model of all major cellular processes, such as macromolecular synthesis and transcriptional regulation and deployed this model to predicting proteome allocation, overflow metabolism, and metal requirements in this model acetogen. In addition we explored the evolutionary significance of tRNA operon structure using the next-gen model and determined the optimal operon structure for bioproduction. Our study substantially enhanced the knowledgebaase for chemolithoautotrophs and their potential for advanced biofuel production. It provides next-generation modeling capability, offer innovative tools for genome-scale engineering, and provide novel methods to utilize next-generation models for the design of tunable systems that produce commodity chemicals from inexpensive sources.

Introducing AstroGen: The Astronomy Genealogy Project

OpenAIRE

Tenn, Joseph S.

2016-01-01

The Astronomy Genealogy Project ("AstroGen"), a project of the Historical Astronomy Division of the American Astronomical Society (AAS), will soon appear on the AAS website. Ultimately, it will list the world's astronomers with their highest degrees, theses for those who wrote them, academic advisors (supervisors), universities, and links to the astronomers or their obituaries, their theses when on-line, and more. At present the AstroGen team is working on those who earned doctorates with ast...

Genética humana e sociedade

OpenAIRE

Rosa, Vivian Leyser da

2000-01-01

Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências da Educação. Análise do campo de estudos sobre o entendimento público da ciência, distinguindo os modelos de deficit cognitivo e interativo, bem como suas implicações na esfera educacional. Estudo do panorama dos avanços atuais da genética humana, do ponto de vista científico, ético e social. Análise de aspectos relativos ao ensino de genética humana nos cursos de graduação da área da saúde, em nove Universidades...

Manipulación genética de seres humanos

OpenAIRE

Manuel Santos Alcántara

2006-01-01

El gran avance que ha tenido la Genética en los últimos años y, particularmente, aquello relacionado con el desciframiento del genoma humano, ha traído a la discusión pública la posibilidad concreta de manipular genéticamente a los seres humanos. El mejoramiento o perfeccionamiento genético de los seres humanos, denominado eugenesia, actualmente se ha convertido técnicamente en una realidad, motivando una profunda reflexión de tipo ético. La pregunta básica es la siguiente: aquello que es téc...

Application of part-whole training methods to evaluate when to introduce NextGen air traffic management tools to students.

Science.gov (United States)

Vu, Kim-Phuong L; Kiken, Ariana; Chiappe, Dan; Strybel, Thomas Z; Battiste, Vernol

2013-01-01

The Next Generation Air Transportation System (NextGen) will use advanced technologies and new concepts of operation to accommodate projected increases in air travel over the next few decades. Use of NextGen tools requires air traffic controllers (ATCos) to use different procedures than those required to manage NextGen-unequipped aircraft, and ATCos will need to integrate the 2 skill sets when managing a sector consisting of NextGen-equipped and unequipped aircraft. The goal of the present study was to determine the effectiveness of 2 procedures in the training of student controllers to manage both equipage types. We applied a variant of the part-whole training paradigm in the present study. Using a quasi-experimental design, we trained students from 2 different labs of an internship course to manage air traffic with potential NextGen tools concurrent with their traditional training (whole-task group) or after they had time to learn traditional air traffic management skills (part-whole group). Participants were then tested in their ability to manage a simulated sector consisting of different percentages of NextGen-equipped and unequipped aircraft at the mid-term and after the final week of their internship. Results showed that it is better to train students in manual ATCo skills before introducing NextGen tools, unless the students are of higher aptitude. For more skilled students, simultaneously introducing NextGen and manual tools into their curriculum had little negative impact.

MODERATE C IV ABSORBER SYSTEMS REQUIRE 1012 M☉ DARK MATTER HALOS AT z ∼ 2.3: A CROSS-CORRELATION STUDY OF C IV ABSORBER SYSTEMS AND QUASARS IN SDSS-III BOSS DR9

International Nuclear Information System (INIS)

Vikas, Shailendra; Wood-Vasey, W. Michael; Lundgren, Britt; Ross, Nicholas P.; Myers, Adam D.; AlSayyad, Yusra; York, Donald G.; Schneider, Donald P.; Brinkmann, J.; Bizyaev, Dmitry; Brewington, Howard; Malanushenko, Elena; Malanushenko, Viktor; Oravetz, Daniel; Pan, Kaike; Snedden, Stephanie; Ge, Jian; Muna, Demitri; Pâris, Isabelle; Petitjean, Patrick

2013-01-01

We measure the two-point cross-correlation function of C IV absorber systems and quasars, using spectroscopic data from the Sloan Digital Sky Survey III Baryon Oscillation Spectroscopic Survey (BOSS; Data Release 9). The 19,701 quasars and 6149 C IV ''moderate'' absorbers, 0.28 Å 2 and represent a factor of two increase in sample size over previous investigations. We find a correlation scale length and slope of the redshift-space cross-correlation function of s 0 = 8.46 ± 1.24 Mpc, γ = 1.68 ± 0.19, in the redshift-space range 10 0 = 7.76 ± 2.80 Mpc, γ = 1.74 ± 0.21. We measure the combined quasar and C IV bias to be b QSO b C I V = 8.81 ± 2.28. Using an estimate of b QSO from the quasar auto-correlation function we find b CIV = 2.38 ± 0.62. This b CIV implies that EW > 0.28 Å C IV absorbers at z ∼ 2.3 are typically found in dark matter halos that have masses ≥10 11.3 -10 13.4 M ☉ at that redshift. The complete BOSS sample will triple the number of both quasars and absorption systems and increase the power of this cross-correlation measurement by a factor of two.

Development of a real-time fuel cell stack modelling solution with integrated test rig interface for the generic fuel cell modelling environment (GenFC) software

Energy Technology Data Exchange (ETDEWEB)

Fraser, S.D.; Monsberger, M.; Hacker, V. [Graz Univ. of Technology, Graz (Austria). Christian Doppler Laboratory for Fuel Cell Systems; Gubner, A.; Reimer, U. [Forschungszentrum Julich, Julich (Germany)

2007-07-01

Since the late 1980s, numerous FC models have been developed by scientists and engineers worldwide to design, control and optimize fuel cells (FCs) and fuel cell (FC) power systems. However, state-of-the-art FC models have only a small range of applications within the versatile field of FC modelling. As fuel cell technology approaches commercialization, the scientific community is faced with the challenge of providing robust fuel cell models that are compatible with established processes in industrial product development. One such process, known as Hardware in the Loop (HiL), requires real-time modelling capability. HiL is used for developing and testing hardware components by adding the complexity of the related dynamic systems with mathematical representations. Sensors and actuators are used to interface simulated and actual hardware components. As such, real-time fuel cell models are among the key elements in the development of the Generic Fuel Cell Modelling Environment (GenFC) software. Six European partners are developing GenFC under the support of the Sixth European Framework Programme for Research and Technological Development (FP6). GenFC is meant to increase the use of fuel cell modelling for systems design and to enable cost- and time-efficient virtual experiments for optimizing operating parameters. This paper presented an overview of the GenFC software and the GenFC HiL functionality. It was concluded that GenFC is going to be an extendable software tool providing FC modelling techniques and solutions to a wide range of different FC modelling applications. By combining the flexibility of the GenFC software with this HiL-specific functionality, GenFC is going to promote the use of FC model-based HiL technology in FC system development. 9 figs.

Estudio molecular del gen MLL en 30 pacientes con leucemias agudas Molecular study of MLL gen in 30 patients with acute leukemias

Directory of Open Access Journals (Sweden)

Raquel Levón Herrera

2000-04-01

Full Text Available Los reordenamientos del gen MLL en la banda cromosómica 11q23 son frecuentes en leucemias agudas (LA en niños y en las LA secundarias desarrolladas después de la terapia con inhibidores de la enzima topoisomerasa II. En menor medida también se aprecia en adultos con LA. La presencia de estos reordenamientos se considera un indicador de mal pronóstico asociado con resultados clínicos desfavorables, por ello es muy importante realizar su determinación en las LA. En este trabajo mostramos los resultados preliminares de la introducción del estudio del gen MLL en nuestro país mediante la técnica de Southern. Analizamos ADN de 30 pacientes con LA, incluidos niños y adultos, que en el momento del estudio se encontraban al debut o en recaída. El estudio molecular se realizó con la sonda FA4, que es un inserto genómico del gen MLL. Sólo uno de los 30 pacientes mostró bandas de reordenamiento con 2 enzimas de restricción diferentes, el resto mostró el gen MLL en configuración germinal. Es interesante destacar que el paciente con el reordenamiento era un niño con leucemia mieloblástica aguda subtipo M5b, lo cual concuerda con la literatura, donde se describe que estos reordenamientos están estrechamente correlacionados con los subtipos mielomonocítico (M4 y monocítico (M5 de leucemia mieloide aguda (LMARearrangements of MLL gen in llq23 chromosomal band are frequents in childhood type of acute leukemia (AL and in secondary AL, developed after therapy with II topoisomerase enzyme. To a lesser extent also is seen in adults with AL. Presence of theses rearrangements is considered to be a worse prognosis indicator, associated with unfavourable clinical results, that is why it is very important to carry our its assessment in AL. In this paper authors present preliminary results from introduction of study on MLL gen in our country through Southern technique. DNA from 30 patients was analized, including children and adults, that at the

A Qualitative Assessment of Diversion Scenarios for an Example Sodium Fast Reactor Using the GEN IV PR and PP Methodology

International Nuclear Information System (INIS)

Zentner, Michael D.; Coles, Garill A.; Therios, Ike

2012-01-01

FAST REACTORS;NUCLEAR ENERGY;NUCLEAR MATERIALS MANAGEMENT;PROLIFERATION;SAFEGUARDS;THEFT; A working group was created in 2002 by the Generation IV International Forum (GIF) for the purpose of developing an internationally accepted methodology for assessing the Proliferation Resistance of a nuclear energy system (NES) and its individual elements. A two year case study is being performed by the experts group using this methodology to assess the proliferation resistance of a hypothetical NES called the Example Sodium Fast Reactor (ESFR). This work demonstrates how the PR and PP methodology can be used to provide important information at various levels of details to NES designers, safeguard administrators and decision makers. The study analyzes the response of the complete ESFR nuclear energy system to different proliferation and theft strategies. The challenges considered include concealed diversion, concealed misuse and 'break out' strategies. This paper describes the work done in performing a qualitative assessment of concealed diversion scenarios from the ESFR.

A Study on intensifying efficiency for international collaborative development of Advanced Nuclear Energy Technology

Energy Technology Data Exchange (ETDEWEB)

Hahn, Dohee; Park, Seongwon; Chang, Moonhee

2013-08-15

All the countries of the world are promoting the use of atomic energy to provide against high oil prices, climatic changes, and energy security initiative. A domestic and foreign environment for nuclear energy is changing rapidly and 13 leading countries including Korea are trying to develop advanced technologies on Gen IV nuclear energy system through Gen IV International Forum (GIF). To enhance the effectiveness of the future nuclear energy system development plan, a strategic approach is necessary for GIF program and the connection process with the 4th Nuclear Energy Promotion Program and Nuclear Energy R and D Medium and Long Term 5 year Plan for 2012 ∼ 2016 needs to be prepared. This study was to analyze the global nuclear trends of 2012 and the status of GIF program which is international cooperation activities. Also we examined the domestic R and D status of future nuclear energy systems for developing core technology and commercialization of Gen-IV nuclear energy system. A successful performance of this project enables the effective national cooperation with GIF and promotes the public acceptance by suggesting the technical alternatives for the nuclear safety and the spent fuel management.

Preliminary Economic Assessment of KALIMER-600

International Nuclear Information System (INIS)

Moon, Kee-Hwan; Kim, Seung-Su; Hahn, Do-Hee

2008-01-01

The GIF(GEN IV International Forum) established an Economic Modelling Working Group(EMWG) in 2003 to create economic models and guidelines to facilitate in a future evaluation of the Generation IV nuclear energy systems and assess progress toward the GIF economic goals. These goals are to have a life cycle cost advantage over other energy sources, and to have a level of financial risk comparable to other energy projects. To do this, EMWG has been developed the G4-ECONS model, which is a generic EXCEL-based model for computation of the projected levelized unit electricity cost and/or levelized non-electricity unit product cost from GEN IV energy systems. KALIMER-600 has been developed as a new design concept based on the KALIMER-150 design. KALIMER-600 is a unique design concept which has a potential to achieve GEN IV technology goals even though there is a room for a design improvement in order to make the KALIMER-600 more competitive with future generation reactors. The objective of this study is to the assess economics of KALIMER-600 by using the G4-ECONS model

Development of the Sodium-cooled Fast Reactor R and D and Technology Monitoring System

International Nuclear Information System (INIS)

Lee, Dong Uk; Won, Byung Chool; Kim, Young In; Hahn, Do Hee

2008-01-01

This study presents a R and D performance monitoring system that is applicable for managing the generation IV sodium-cooled fast reactor development. The prime goal of this system is to furnish project manager with reliable and accurate information of status of progress, performance and resource allocation, and attain traceability and visibility of project implementation for effective project management. In this study, the work breakdown structure, the related schedule and the expected outputs were established to derive the interfaces between projects and the above parameters was loaded PCs. The R and D performance monitoring system is composed of about 750 R and D activities within 'Development of Basic Key Technologies for Gen IV SFR' project in 2007. The Microsoft Project Professional software was used to monitor the progress, evaluate the results and analyze the resource distribution to activities

Development of the Sodium-cooled Fast Reactor R and D and Technology Monitoring System

Energy Technology Data Exchange (ETDEWEB)

Lee, Dong Uk; Won, Byung Chool; Kim, Young In; Hahn, Do Hee

2008-01-15

This study presents a R and D performance monitoring system that is applicable for managing the generation IV sodium-cooled fast reactor development. The prime goal of this system is to furnish project manager with reliable and accurate information of status of progress, performance and resource allocation, and attain traceability and visibility of project implementation for effective project management. In this study, the work breakdown structure, the related schedule and the expected outputs were established to derive the interfaces between projects and the above parameters was loaded PCs. The R and D performance monitoring system is composed of about 750 R and D activities within 'Development of Basic Key Technologies for Gen IV SFR' project in 2007. The Microsoft Project Professional software was used to monitor the progress, evaluate the results and analyze the resource distribution to activities.

Generating randomised virtualised scenarios for ethical hacking and computer security education: SecGen implementation and deployment

OpenAIRE

Schreuders, ZC; Ardern, L

2015-01-01

Computer security students benefit from having hands-on experience with hacking tools and with access to vulnerable systems that they can attack and defend. However, vulnerable VMs are static; once they have been exploited by a student there is no repeatable challenge as the vulnerable boxes never change. A new novel solution, SecGen, has been created and deployed. SecGen solves the issue by creating vulnerable machines with randomised vulnerabilities and services, with constraints that ensur...

Comparative kinetic and equilibrium investigations on the extraction of U(IV) in nitric acid/Tbp or TLA-Kerosene systems

Energy Technology Data Exchange (ETDEWEB)

Daoud, J A; Khalifa, S M; Abdel Rahman, N; Aly, H F [Hot laboratories center, Atomic energy authority post code 13758, (Egypt)

1995-10-01

The extraction equilibrium of U(IV) by tributyl-phosphate (Tbp) or trilaurylamine (TLA) in kerosene from nitric acid media was investigated. The effect of the different parameters affecting the extraction was separately studied and compared. The kinetics of extraction of U(IV) by Tbp or TLA was also investigated using a stirred lewis cell. The data showed that the rate of extraction of U(IV) by Tbp is controlled by chemical reactions at the interface. In the TLA system, the extraction of U(IV) is controlled by chemical reactions at the interface and bulk phase. Rate equations show that the extraction of U(IV) is first order dependent on Tbp concentration while it is of fractional negative order with respect to TLA. The effect of temperature on the rate of extraction was also studied and the thermodynamic functions were evaluated for the two systems. 5 figs.

Genética em transtornos alimentares: ampliando os horizontes de pesquisa

Directory of Open Access Journals (Sweden)

Pinheiro Andréa Poyastro

2006-01-01

Full Text Available OBJETIVO: Revisar a literatura atual concernente à pesquisa genética em transtornos do comportamento alimentar e discutir questões relevantes ao desenvolvimento de um projeto de pesquisa genética nessa área no Brasil. MÉTODO: A revisão realizada utilizou a base de dados Medline, no período de 1984 a maio de 2005, com os seguintes termos de busca: "anorexia nervosa", "bulimia nervosa", "eating disorders", "binge eating disorder", "family studies", "twin studies", "molecular genetics studies". RESULTADOS: Os dados atuais apontam para uma contribuição relevante dos fatores genéticos na suscetibilidade à anorexia e à bulimia nervosa. A pesquisa genética com populações miscigenadas deve levar em consideração o tamanho da amostra, a densidade de genotipagem e a estratificação populacional. Através de "admixture mapping" é possível estimar a estrutura genética destas populações e localizar genes relacionados à variação étnica de doenças ou traços de interesse. CONCLUSÕES: O desenvolvimento de uma grande iniciativa de colaboração em genética de transtornos alimentares no Brasil e na América Latina viabilizará estudar os fatores genéticos em transtornos do comportamento alimentar no contexto de grupos inter-étnicos, e integrar uma nova perspectiva biológica à etiologia destes distúrbios.

Resistência genética em genótipos de feijoeiro a Curtobacterium flaccumfaciens pv. flaccumfaciens Genetic resistance to Curtobacterium flaccumfaciens pv. flaccumfaciens in bean genotypes

Directory of Open Access Journals (Sweden)

Valmir Luiz de Souza

2006-09-01

Full Text Available Curtobacterium flaccumfaciens pv. flaccumfaciens (Cff agente causal da murcha-de-curtobacterium em feijoeiro (Phaseolus vulgaris, é um patógeno vascular de difícil controle. A doença foi detectada pela primeira vez no Brasil na safra das águas de 1995, no Estado de São Paulo. Por se tratar de uma doença de difícil controle, a resistência genética tem sido a melhor opção. O objetivo deste trabalho foi avaliar a reação de genótipos de feijoeiro à murcha-de-curtobacterium, frente a 333 acessos pertencentes ao banco de germoplasma de feijoeiro do Instituto Agronômico de Campinas (IAC. Oportunamente, foram selecionados genótipos de feijoeiro altamente resistentes e suscetíveis, com a finalidade de comparar a colonização de Cff no vaso do xilema a partir da visualização sob microscopia eletrônica de varredura. Os resultados da triagem da resistência genética em genótipos de feijoeiro indicaram a existência de variabilidade genética nas amostras dos 333 genótipos avaliados, ao isolado de Cff Feij 2634. Os materiais foram classificados em 4 grupos de resistência: 29 genótipos (8,7% comportaram-se como altamente resistentes, 13 genótipos (3,9% como resistentes, 18 genótipos (5% como moderadamente resistentes e 273 genótipos (81% suscetíveis. A partir dos resultados obtidos, cerca de 18% dos genótipos de feijoeiros, desde altamente resistentes à moderadamente resistentes, poderão ser úteis para o programa de melhoramento genético como fonte de genes para resistência a Cff. Através da microscopia eletrônica de varredura, foram observadas em genótipos altamente resistentes, várias aglutinações da bactéria envolvidas por filamentos e estruturas rendilhadas sob pontuações da parede do vaso do xilema, não verificados em genótipos suscetíveis, o que sugere a ativação de mecanismos de defesa estruturais e bioquímicos nas plantas resistentes.Curtobacterium flaccumfaciens pv. flaccumfaciens (Cff, the causal

Assessment of Proliferation Resistance of Closed Nuclear Fuel Cycle System with Sodium Cooled Fast Reactors Using INPRO Evaluation Methodology

International Nuclear Information System (INIS)

Kim, Young In; Hahn, Do Hee; Won, Byung Chool; Lee, Dong Uk

2007-11-01

Using the INPRO methodology, the proliferation resistance of an innovative nuclear energy system(INS) defined as a closed nuclear fuel cycle system consisting of KALIMER and pyroprocessing, has been assessed. Considering a very early development stage of the INS concept, the PR assessment is carried out based on intrinsic features, if required information and data are not available. The PR assessment of KALIMER and JSFR using the INPRO methodology affirmed that an adequate proliferation resistance has been achieved in both INSs CNFC-SFR, considering the assessor's progress and maturity of design development. KALIMER and JSFR are developed or being developed conforming to the targets and criteria defined for developing Gen IV nuclear reactor system. Based on these assessment results, proliferation resistance and physical protection(PR and PP) of KALIMER and JSFR are evaluated from the viewpoint of requirements for future nuclear fuel cycle system. The envisioned INSs CNFC-SFR rely on active plutonium management based on a closed fuel cycle, in which a fissile material is recycled in an integrated fuel cycle facility within proper safeguards. There is no isolated plutonium in the closed fuel cycle. The material remains continuously in a sequence of highly radioactive matrices within inaccessible facilities. The proliferation resistance assessment should be an ongoing analysis that keeps up with the progress and maturity of the design of Gen IV SFR

Assessment of Proliferation Resistance of Closed Nuclear Fuel Cycle System with Sodium Cooled Fast Reactors Using INPRO Evaluation Methodology

Energy Technology Data Exchange (ETDEWEB)

Kim, Young In; Hahn, Do Hee; Won, Byung Chool; Lee, Dong Uk

2007-11-15

Using the INPRO methodology, the proliferation resistance of an innovative nuclear energy system(INS) defined as a closed nuclear fuel cycle system consisting of KALIMER and pyroprocessing, has been assessed. Considering a very early development stage of the INS concept, the PR assessment is carried out based on intrinsic features, if required information and data are not available. The PR assessment of KALIMER and JSFR using the INPRO methodology affirmed that an adequate proliferation resistance has been achieved in both INSs CNFC-SFR, considering the assessor's progress and maturity of design development. KALIMER and JSFR are developed or being developed conforming to the targets and criteria defined for developing Gen IV nuclear reactor system. Based on these assessment results, proliferation resistance and physical protection(PR and PP) of KALIMER and JSFR are evaluated from the viewpoint of requirements for future nuclear fuel cycle system. The envisioned INSs CNFC-SFR rely on active plutonium management based on a closed fuel cycle, in which a fissile material is recycled in an integrated fuel cycle facility within proper safeguards. There is no isolated plutonium in the closed fuel cycle. The material remains continuously in a sequence of highly radioactive matrices within inaccessible facilities. The proliferation resistance assessment should be an ongoing analysis that keeps up with the progress and maturity of the design of Gen IV SFR.

Consideraciones genéticas sobre las dislipidemias y la aterosclerosis

OpenAIRE

Julio César Fernández Travieso

2008-01-01

La interacción entre factores genéticos y ambientales explican muchos aspectos de la aterosclerosis y las variaciones genéticas constituyen marcadores de riesgo de la enfermedad coronaria (EC), la cual ocupa el primer lugar entre las causas de morbilidad y mortalidad a nivel mundial. La predisposición familiar a padecer EC, junto al avance vertiginoso en técnicas de análisis de ADN y la disponibilidad de secuencias del genoma humano, han orientado la investigación de alteraciones genéticas re...

Hepatic imaging in stage IV-S neuroblastoma

International Nuclear Information System (INIS)

Franken, E.A. Jr.; Smith, W.L.; Iowa Univ., Iowa City; Cohen, M.D.; Kisker, C.T.; Platz, C.E.

1986-01-01

Stage IV-S neuroblastoma describes a group of infants with tumor spread limited to liver, skin, or bone marrow. Such patients, who constitute about 25% of affected infants with neuroblastoma, may expect spontaneous tumor remission. We report 18 infants with Stage IV-S neuroblastoma, 83% of whom had liver involvement. Imaging investigations included Technetium 99m sulfur colloid scan, ultrasound, and CT. Two patterns of liver metastasis were noted: ill-defined nodules or diffuse tumor throughout the liver. Distinction of normal and abnormal liver with diffuse type metastasis could be quite difficult, particularly with liver scans. We conclude that patients with Stage IV-S neuroblastoma have ultrasound or CT examination as an initial workup, with nuclear medicine scans reserved for followup studies. (orig.)

Divergencia genética en poblaciones peruanas detectada a partir de las frecuencias haplotípicas del mtDNA y del gen nuclear MBL

Directory of Open Access Journals (Sweden)

Jesús H. Córdova

2011-01-01

Full Text Available Objetivos: Avanzar en el conocimiento del origen de las poblaciones peruanas estudiadas en un contexto filogeográfico. Diseño: Estudio genético poblacional. Instituciones: Laboratorio de Genética Humana, Facultad de Ciencias Biológicas, Universidad Nacional Mayor de San Marcos, e Instituto de Genética y Biología Molecular, Facultad de Medicina, Universidad San Martín de Porras, Lima, Perú. Participantes: Siete poblaciones peruanas. Metodología: Análisis comparativo de los resultados a partir del estudio del mtDNA y el gen nuclear MBL de siete poblaciones peruanas, procesados de manera separada y luego combinados, utilizando el programa PHYLYP 3.65, para obtener valores FST de diferenciación genética y la construcción de árboles de distancias por aplicación del algorritmo UPGMA y el análisis subsecuente de los agrupamientos (clusters generados. Principales medidas de resultados: Árboles genéticos generados. Resultados: De manera separada, los árboles generados para cada marcador genético tuvieron topologías propias y diferentes entre sí. Procesados de manera combinada, el árbol resultante demostró que los mayores valores de diferenciación genética se hallaron en las Islas del Lago Titicaca (Puno, Perú conocidas -Taquile, Amantani y Anapia-, que fue calificada como muy alta, porque mostró valores de FST de 0.3113, 0.2949 y 0.3348 respecto de las poblaciones estudiadas, tanto fuera del Departamento de Puno -como Chachapoyas, Pucallpa y Chiclayo, respectivamente-, así como a la de los Uro del mismo Puno y del mismo Lago Titicaca (0.2837. Fuera de Puno, el par de poblaciones Chachapoyas-Pucallpa fue el menos divergente, al alcanzar entre ellas un valor de FST de 0.0108, calificándosele de pequeña. Conclusiones: El árbol obtenido del procesamiento de los marcadores vía una matriz combinada demostró que las poblaciones que habitan las islas de Taquile, Amantani y Anapia, divergen notablemente de las restantes cuatro

Heat and power from MicroGen

Energy Technology Data Exchange (ETDEWEB)

Anon.

1999-10-01

This paper reports on the design of a domestic gas-fired cogeneration system developed to replace the central heating boiler. Technical details of the MicroGen demonstration unit are given, and the use of a Linear Free Piston Stirling Engine as the prime mover, and the results of modelling studies of energy demand indicating cost savings compared to conventional boilers are discussed. The enhancement of the benefits of micro-cogeneration through use of thermal and power storage and energy demand management, and the impact of micro-cogeneration on energy use in the home are considered. The UK and European Commission's targets for increased cogeneration capacity are noted.

Towards an International Culture: Gen Y Students and SNS?

Science.gov (United States)

Lichy, Jessica

2012-01-01

This article reports the findings of a small-scale investigation into the Internet user behaviour of generation Y (Gen Y) students, with particular reference to social networking sites. The study adds to the literature on cross-cultural Internet user behaviour with specific reference to Gen Y and social networking. It compares how a cohort of…

Introducing AstroGen: the Astronomy Genealogy Project

Science.gov (United States)

Tenn, Joseph S.

2016-12-01

The Astronomy Genealogy Project (AstroGen), a project of the Historical Astronomy Division of the American Astronomical Society (AAS), will soon appear on the AAS website. Ultimately, it will list the world's astronomers with their highest degrees, theses for those who wrote them, academic advisors (supervisors), universities, and links to the astronomers or their obituaries, their theses when online, and more. At present the AstroGen team is working on those who earned doctorates with astronomy-related theses. We show what can be learned already, with just ten countries essentially completed.

An Antarctic hypotrichous ciliate, Parasterkiella thompsoni (Foissner) nov. gen., nov. comb., recorded in Argentinean peat-bogs: morphology, morphogenesis, and molecular phylogeny.

Science.gov (United States)

Küppers, Gabriela Cristina; Paiva, Thiago da Silva; Borges, Bárbara do Nascimento; Harada, Maria Lúcia; Garraza, Gabriela González; Mataloni, Gabriela

2011-05-01

The ciliate Parasterkiella thompsoni (Foissner, 1996) nov. gen., nov. comb. was originally described from Antarctica. In the present study, we report the morphology, morphogenesis during cell division, and molecular phylogeny inferred from the 18S-rDNA sequence of a population isolated from the Rancho Hambre peat bog, Tierra del Fuego Province (Argentina). The study is based on live and protargol-impregnated specimens. Molecular phylogeny was inferred from trees constructed by means of the maximum parsimony, neighbor joining, and Bayesian analyses. The interphase morphology matches the original description of the species. During the cell division, stomatogenesis begins with the de novo proliferation of two fields of basal bodies, each one left of the postoral ventral cirri and of transverse cirri, which later unify. Primordia IV-VI of the proter develop from disaggregation of cirrus IV/3, while primordium IV of the opisthe develops from cirrus IV/2 and primordia V and VI from cirrus V/4. Dorsal morphogenesis occurs in the Urosomoida pattern-that is, the fragmentation of kinety 3 is lacking. Three macronuclear nodules are generated before cytokinesis. Phylogenetic analyses consistently placed P. thompsoni within the stylonychines. New data on the morphogenesis of the dorsal ciliature justifies the transference of Sterkiella thompsoni to a new genus Parasterkiella. Copyright © 2011 Elsevier GmbH. All rights reserved.

Modeling and Evaluating Pilot Performance in NextGen: Review of and Recommendations Regarding Pilot Modeling Efforts, Architectures, and Validation Studies

Science.gov (United States)

Wickens, Christopher; Sebok, Angelia; Keller, John; Peters, Steve; Small, Ronald; Hutchins, Shaun; Algarin, Liana; Gore, Brian Francis; Hooey, Becky Lee; Foyle, David C.

2013-01-01

NextGen operations are associated with a variety of changes to the national airspace system (NAS) including changes to the allocation of roles and responsibilities among operators and automation, the use of new technologies and automation, additional information presented on the flight deck, and the entire concept of operations (ConOps). In the transition to NextGen airspace, aviation and air operations designers need to consider the implications of design or system changes on human performance and the potential for error. To ensure continued safety of the NAS, it will be necessary for researchers to evaluate design concepts and potential NextGen scenarios well before implementation. One approach for such evaluations is through human performance modeling. Human performance models (HPMs) provide effective tools for predicting and evaluating operator performance in systems. HPMs offer significant advantages over empirical, human-in-the-loop testing in that (1) they allow detailed analyses of systems that have not yet been built, (2) they offer great flexibility for extensive data collection, (3) they do not require experimental participants, and thus can offer cost and time savings. HPMs differ in their ability to predict performance and safety with NextGen procedures, equipment and ConOps. Models also vary in terms of how they approach human performance (e.g., some focus on cognitive processing, others focus on discrete tasks performed by a human, while others consider perceptual processes), and in terms of their associated validation efforts. The objectives of this research effort were to support the Federal Aviation Administration (FAA) in identifying HPMs that are appropriate for predicting pilot performance in NextGen operations, to provide guidance on how to evaluate the quality of different models, and to identify gaps in pilot performance modeling research, that could guide future research opportunities. This research effort is intended to help the FAA

A Study of Future Communications Concepts and Technologies for the National Airspace System - Part IV

Science.gov (United States)

Ponchak, Denise S.; Apaza, Rafael D.; Wichgers, Joel M.; Haynes, Brian; Roy, Aloke

2015-01-01

The National Aeronautics and Space Administration (NASA) Glenn Research Center (GRC) is investigating current and anticipated wireless communications concepts and technologies that the National Airspace System (NAS) may need in the next 50 years. NASA has awarded three NASA Research Announcements (NAR) studies with the objective to determine the most promising candidate technologies for air-to-air and air-to-ground data exchange and analyze their suitability in a post-NextGen NAS environment. This paper will present the final results describing the communications challenges and opportunities that have been identified as part of the study.

The 1st reveal of Gen-V nuclear energy. Prospecting investigation of nuclear power 2050 (A2050) for energy innovation in the nuclear industry

International Nuclear Information System (INIS)

Woo, Tae Ho; Lee, Soon Ho

2012-01-01

The proposed strategy for the future nuclear energy is analyzed. The conventional nuclear power plants (NPPs) are investigated by the 21 st style interdisciplinary research as the information technology (IT), nanotechnology (NT), and biological technology (BT). New kinds of energy production methods as spherical isotropic power reactor (SIPR) and nano lattice power (NLP) are introduced. In addition, the problems of Gen-IV technologies are challenged to be solved, which is the matters of the mechanical and thermal controls of several coolants cases. The simulation result shows the increasing for the usefulness of the business. The core and vessel are very tractable due to moving core vessel (SIPR). The concept of safety system is changed to be submerged into coolant instead of injection concept (SIPR). The commercial fusion energy is realized for mass energy productions (NLP). Eventually, the safety as well as economical status is increased comparing to previous NPPs. (orig.)

Painlevé IV coherent states

Energy Technology Data Exchange (ETDEWEB)

Bermudez, David, E-mail: david.bermudez@weizmann.ac.il [Department of Physics of Complex Systems, Weizmann Institute of Science, Rehovot 76100 (Israel); Departamento de Física, Cinvestav, A.P. 14-740, 07000 México D.F. (Mexico); Contreras-Astorga, Alonso, E-mail: aloncont@iun.edu [Department of Mathematics and Actuarial Science, Indiana University Northwest, 3400 Broadway, Gary IN 46408 (United States); Departamento de Física, Cinvestav, A.P. 14-740, 07000 México D.F. (Mexico); Fernández C, David J., E-mail: david@fis.cinvestav.mx [Departamento de Física, Cinvestav, A.P. 14-740, 07000 México D.F. (Mexico)

2014-11-15

A simple way to find solutions of the Painlevé IV equation is by identifying Hamiltonian systems with third-order differential ladder operators. Some of these systems can be obtained by applying supersymmetric quantum mechanics (SUSY QM) to the harmonic oscillator. In this work, we will construct families of coherent states for such subset of SUSY partner Hamiltonians which are connected with the Painlevé IV equation. First, these coherent states are built up as eigenstates of the annihilation operator, then as displaced versions of the extremal states, both involving the related third-order ladder operators, and finally as extremal states which are also displaced but now using the so called linearized ladder operators. To each SUSY partner Hamiltonian corresponds two families of coherent states: one inside the infinite subspace associated with the isospectral part of the spectrum and another one in the finite subspace generated by the states created through the SUSY technique. - Highlights: • We use SUSY QM to obtain Hamiltonians with third-order differential ladder operators. • We show that these systems are related with the Painlevé IV equation. • We apply different definitions of coherent states to these Hamiltonians using the third-order ladder operators and some linearized ones. • We construct families of coherent states for such systems, which we called Painlevé IV coherent states.

Painlevé IV coherent states

International Nuclear Information System (INIS)

Bermudez, David; Contreras-Astorga, Alonso; Fernández C, David J.

2014-01-01

A simple way to find solutions of the Painlevé IV equation is by identifying Hamiltonian systems with third-order differential ladder operators. Some of these systems can be obtained by applying supersymmetric quantum mechanics (SUSY QM) to the harmonic oscillator. In this work, we will construct families of coherent states for such subset of SUSY partner Hamiltonians which are connected with the Painlevé IV equation. First, these coherent states are built up as eigenstates of the annihilation operator, then as displaced versions of the extremal states, both involving the related third-order ladder operators, and finally as extremal states which are also displaced but now using the so called linearized ladder operators. To each SUSY partner Hamiltonian corresponds two families of coherent states: one inside the infinite subspace associated with the isospectral part of the spectrum and another one in the finite subspace generated by the states created through the SUSY technique. - Highlights: • We use SUSY QM to obtain Hamiltonians with third-order differential ladder operators. • We show that these systems are related with the Painlevé IV equation. • We apply different definitions of coherent states to these Hamiltonians using the third-order ladder operators and some linearized ones. • We construct families of coherent states for such systems, which we called Painlevé IV coherent states

Conceptos básicos de programación genética

Directory of Open Access Journals (Sweden)

José Jesús Martínez Páez

2001-04-01

Full Text Available La Programación Genética, PG, es un retoño de los Algoritmos Genéticos, en la cual los cromosomas que sufren la adaptación son en sí mismos programas de computador. Se usan operadores genéticos  especializados que generalizan la recombinación sexual y la mutación, para los programas de computador estructurados en árbol que están bajo adaptación.

AtlasT4SS: a curated database for type IV secretion systems.

Science.gov (United States)

Souza, Rangel C; del Rosario Quispe Saji, Guadalupe; Costa, Maiana O C; Netto, Diogo S; Lima, Nicholas C B; Klein, Cecília C; Vasconcelos, Ana Tereza R; Nicolás, Marisa F

2012-08-09

The type IV secretion system (T4SS) can be classified as a large family of macromolecule transporter systems, divided into three recognized sub-families, according to the well-known functions. The major sub-family is the conjugation system, which allows transfer of genetic material, such as a nucleoprotein, via cell contact among bacteria. Also, the conjugation system can transfer genetic material from bacteria to eukaryotic cells; such is the case with the T-DNA transfer of Agrobacterium tumefaciens to host plant cells. The system of effector protein transport constitutes the second sub-family, and the third one corresponds to the DNA uptake/release system. Genome analyses have revealed numerous T4SS in Bacteria and Archaea. The purpose of this work was to organize, classify, and integrate the T4SS data into a single database, called AtlasT4SS - the first public database devoted exclusively to this prokaryotic secretion system. The AtlasT4SS is a manual curated database that describes a large number of proteins related to the type IV secretion system reported so far in Gram-negative and Gram-positive bacteria, as well as in Archaea. The database was created using the RDBMS MySQL and the Catalyst Framework based in the Perl programming language and using the Model-View-Controller (MVC) design pattern for Web. The current version holds a comprehensive collection of 1,617 T4SS proteins from 58 Bacteria (49 Gram-negative and 9 Gram-Positive), one Archaea and 11 plasmids. By applying the bi-directional best hit (BBH) relationship in pairwise genome comparison, it was possible to obtain a core set of 134 clusters of orthologous genes encoding T4SS proteins. In our database we present one way of classifying orthologous groups of T4SSs in a hierarchical classification scheme with three levels. The first level comprises four classes that are based on the organization of genetic determinants, shared homologies, and evolutionary relationships: (i) F-T4SS, (ii) P-T4SS, (iii

Journal of Sustainable Development of Energy, Water and Environment Systems – Volume IV

Directory of Open Access Journals (Sweden)

Neven Duić

2016-12-01

In total 32 manuscripts were published in Volume IV, all of them reviewed by at least two reviewers. The Journal of Sustainable Development of Energy, Water and Environment Systems would like to thank reviewers for their contribution to the quality of the published manuscripts.

About the structure and stability of complex carbonates of thorium (IV), cerium (IV), zirconium (IV), hafnium (IV)

International Nuclear Information System (INIS)

Dervin, Jacqueline

1972-01-01

This research thesis addressed the study of complex carbonates of cations of metals belonging to the IV A column, i.e. thorium (IV), zirconium (IV), hafnium (IV), and also cerium (IV) and uranium (VI), and more particularly focused on ionic compounds formed in solution, and also on the influence of concentration and nature of cations on stability and nature of the formed solid. The author first presents methods used in this study, discusses their precision and scope of validity. She reports the study of the formation of different complex ions which have been highlighted in solution, and the determination of their formation constants. She reports the preparation and study of the stability domain of solid complexes. The next part reports the use of thermogravimetric analysis, IR spectrometry, and crystallography for the structural study of these compounds

CLONACIÓN Y FILOGENIA MOLECULAR DE UN SEGMENTO DEL GEN CODANTE DE LA ACTINA DE MYRCIARIA DUBIA “CAMU-CAMU”: UN CANDIDATO PARA GEN DE REFERENCIA

Directory of Open Access Journals (Sweden)

Juan Carlos Castro Gómez

2012-12-01

Full Text Available Myrciaria dubia “camu-camu” es un frutal amazónico caracterizado por su amplia variación de vitamina C. Pero los estudios genético moleculares que puedan explicar esta variación son limitados. Por ello nuestro objetivo fue realizar la clonación y filogenia molecular de un segmento del gen codante de la actina de M. dubia. Las muestras fueron obtenidas de la colección de germoplasma del INIA. Luego, el ARN fue purificado y mediante RT-PCR con cebadores degenerados se amplificó un segmento del gen. En base a la secuencia obtenida se diseñaron cebadores específicos para PCR en tiempo real. Los resultados muestran que se ha aislado, clonado y secuenciado un segmento del gen codante de actina de M. dubia y detectado su expresión en hojas, pulpa y cáscara de M. dubia. Así, con el soporte de herramientas bioinformáticas y uso de técnicas de biología molecular hemos aislado, clonado y secuenciado un segmento del gen codante de la actina de M. dubia. Asimismo, los análisis realizados muestran que el gen se expresa y presenta niveles similares de expresión en hojas, pulpa y cáscara de M. dubia. Sin embargo, es necesario realizar más experimentos a fin de verificar su estabilidad de expresión.

Aproximación genómica al diagnóstico genético de las distrofias hereditarias de retina y búsqueda de nuevos genes relacionados

OpenAIRE

González del Pozo, María

2014-01-01

Diagnosticar genéticamente a las familias afectas de alguna de las distrofias hereditarias de retina (DHR) es, desde el punto de vista del genetista, una tarea ardua y complicada, si atendemos a la gran cantidad de genes y mutaciones reportados hasta la fecha. La gran heterogeneidad clínica y genética que caracteriza a este conjunto de enfermedades, es sin duda el mayor impedimento para su resolución genética. En este escenario, el empleo de herramientas cada vez más poderosas es indispensabl...

Genética e hanseníase

OpenAIRE

Beiguelman Bernardo

2002-01-01

As diferentes linhas de pesquisa utilizadas para investigar a importância dos fatores hereditários humanos na determinação da resistência/suscetibilidade à infecção pelo Mycobacterium leprae foram discutidas no presente trabalho. Uma síntese dessas abordagens permitiu analisar os resultados das investigações sobre associação da hanseníase com polimorfismos genéticos, distribuição familial da hanseníase, prevalência da hanseníase e distância genética, concordância da hanseníase em gêmeos e est...

Analisis Mutasi Gen Protein X Virus Hbv Pada Penderita Hepatitis B Akut Di Manado

OpenAIRE

Fatimawali; Kepel, Billy

2014-01-01

Faktor-faktor yang mempengaruhi perkembangan hepatitis B kronis menjadi kanker hati antara lain mutasi pada gen x. Penelitian ini bertujuan untuk mengidentifikasi gen protein x virus HBV dan menganalisis apakah terjadi mutasi gen yang terkait dengan munculnya tumor ganas sirosis hati (HCC). Penelitian ini menggunakan primer untuk proses nested PCR yang telah dirancang sebelumnya. Proses nested PCR terhadap 10 sampel DNA HBV pasien dilakukan untuk mengamplifikasi fragmen DNA gen x dilanjutkan ...

The 1{sup st} reveal of Gen-V nuclear energy. Prospecting investigation of nuclear power 2050 (A2050) for energy innovation in the nuclear industry

Energy Technology Data Exchange (ETDEWEB)

Woo, Tae Ho [Seoul National Univ. (Korea, Republic of). Dept. of Nuclear Engineering; Lee, Seok Jong [POSCO Engineering and Construction Co., Ltd., Incheon (Korea, Republic of); Lee, Soon Ho [SK Engineering and Construction Co., Ltd., Seoul (Korea, Republic of)

2012-11-15

The proposed strategy for the future nuclear energy is analyzed. The conventional nuclear power plants (NPPs) are investigated by the 21{sup st} style interdisciplinary research as the information technology (IT), nanotechnology (NT), and biological technology (BT). New kinds of energy production methods as spherical isotropic power reactor (SIPR) and nano lattice power (NLP) are introduced. In addition, the problems of Gen-IV technologies are challenged to be solved, which is the matters of the mechanical and thermal controls of several coolants cases. The simulation result shows the increasing for the usefulness of the business. The core and vessel are very tractable due to moving core vessel (SIPR). The concept of safety system is changed to be submerged into coolant instead of injection concept (SIPR). The commercial fusion energy is realized for mass energy productions (NLP). Eventually, the safety as well as economical status is increased comparing to previous NPPs. (orig.)

Caracterización del gen mecA de Staphylococcus aureus resistentes a meticilina aislados de tres grupos poblacionales de la ciudad de Medellín

Directory of Open Access Journals (Sweden)

Marcela Sanchez

Full Text Available Introducción: Staphylococcus aureus resistente a la meticilina (SARM es responsable de infecciones intrahospitalarias, las que constituyen una importante causa de morbilidad y mortalidad en nuestro medio, por lo cual la rápida identificación y tipificación molecular de la resistencia como el complejo SSCmec es esencial para entender la epidemiología de la infección. Objetivo: Caracterizar fenotípicamente la resistencia a meticilina y genotípicamente el casete cromosomal SSCmec en cepas de S. aureus aislados de individuos de la ciudad de Medellín mediante PCR múltiple. Materiales y métodos: A 41 aislamientos (hospitalarios y de la comunidad de S. aureus se les estableció la resistencia a cefoxitin mediante la técnica de Kirby-Bauer y la concentración inhibitoria mínima para oxacilina. Mediante PCR convencional se les confirmó la presencia del gen mecA. Para la tipificación del complejo SSCmec se utilizó PCR múltiple para amplificar 6 loci diferentes de este gen. Resultados: A todos los aislamientos se les confirmó resistencia a meticilina y la presencia del gen mecA, de los cuales 17 fueron clasificados como SSC mec I, 1 como SSC mec II, 21 como SSC mecIV; dos aislamientos no fue posible clasificarlos. Conclusiones: Con el uso de esta técnica clasificamos el 95% de los aislamientos del estudio, encontrando una mayor prevalencia de los SSCmec I y IV. La implementación de esta técnica permite una fácil caracterización de los aislamientos SARM y un apropiado manejo de la información de los integrantes de los comités de infecciones hospitalarios, lo cual podría impactar positivamente en el tratamiento a los pacientes y el control de enfermedades infecciosas intrahospitalarias.

Craniostenose em gêmeos: estudo genético

Directory of Open Access Journals (Sweden)

Walter Carlos Pereira

1968-09-01

Full Text Available É relatada a ocorrência de formas clínicas diversas de craniostenose em gêmeos de sexo diferente. A menina apresentava obliteração completa da sutura coronaria e dos dois terços anteriores da sutura sagital; no menino a sutura sagital era a única afetada. O estudo genético mostrou que a craniostenose independe de aberrações cromossômicas, indicando ser transmitida por gens recessivos raros de natureza autossômica.

DEVELOPMENT OF A METHODOLOGY TO ASSESS PROLIFERATION RESISTANCE AND PHYSICAL PROTECTION FOR GENERATION IV SYSTEMS

International Nuclear Information System (INIS)

Nishimura, R.; Bari, R.; Peterson, P.; Roglans-Ribas, J.; Kalenchuk, D.

2004-01-01

Enhanced proliferation resistance and physical protection (PR and PP) is one of the technology goals for advanced nuclear concepts, such as Generation IV systems. Under the auspices of the Generation IV International Forum, the Office of Nuclear Energy, Science and Technology of the U.S. DOE, the Office of Nonproliferation Policy of the National Nuclear Security Administration, and participating organizations from six other countries are sponsoring an international working group to develop an evaluation methodology for PR and PP. This methodology will permit an objective PR and PP comparison between alternative nuclear systems (e.g., different reactor types or fuel cycles) and support design optimization to enhance robustness against proliferation, theft and sabotage. The paper summarizes the proposed assessment methodology including the assessment framework, measures used to express the PR and PP characteristics of the system, threat definition, system element and target identification, pathway identification and analysis, and estimation of the measures

A Review of Alloy 800H for Applications in the Gen IV Nuclear Energy Systems

International Nuclear Information System (INIS)

Ren, Weiju; Swindeman, Robert W.

2010-01-01

Alloy 800H is currently under consideration for applications in the Next Generation Nuclear Plant at operational temperatures above 750 C. To provide supporting information in this paper at the attempt to facilitate the consideration, service requirements of the nuclear system for structural materials is first described; and then an extensive review of Alloy 800H is given on its codification with respect to development and research history, mechanical behavior and design allowables, metallurgical aging resistance, environmental effect considerations, data requirements and availability, weldments, as well as many other aspects relevant to the intended nuclear application; an finally further research and development activities to support the materials qualification are suggested.

Transformação genética em espécies florestais.

OpenAIRE

Claudia Studart-Guimarães; Cristiano Lacorte; Ana Cristina Miranda Brasileiro

2010-01-01

A transformação genética, que compreende a introdução de genes exógenos de forma controlada no genoma de uma célula vegetal e posterior regeneração da planta transgênica, tem contribuído com os programas de melhoramento genético de plantas pela obtenção de genótipos com novas características de interesse. O melhoramento de espécies florestais é limitado por características intrínsecas a tais espécies, como a altura dos indivíduos e o ciclo longo de vida. A transformação genética constitui, po...

A SCWR core design with a conceptual fuel assembly using a cruciform moderator

International Nuclear Information System (INIS)

Bae, Kang Mok; Joo, Hyung Kook; Lee, Hyun Chul; Noh, Jae Man; Bae, Yoon Yong

2005-01-01

A super critical water cooled reactor (SCWR) system has a potential to compete with the advanced fossil plant by achieving a high thermal efficiency up to 44% and a plant simplification by eliminating steam generators, steam dryers, steam separators, and recirculation pumps. Due to these advantages, a SCWR is considered as one of the most promising nuclear plants for the Generation-IV (Gen-IV) system. As a first step of a feasibility study a rectangular fuel assembly with a cruciform solid moderator was suggested as a conceptual assembly design at the Korea Atomic Energy Research Institute (KAERI) for the SCWR on a thermal neutron spectrum. In this paper, based on the system parameters proposed by the Gen-IV road map, a preliminary SCWR core design was performed using a conceptual assembly design focused on the power shape control, reactivity coefficients, and cladding temperature limit

Preserving Accuracy in GenBank

DEFF Research Database (Denmark)

Bidartondo, M.I.; Bruns, T. D.; Blackwell, M.

2008-01-01

GenBank, the public repository for nucleotide and protein sequences, is a critical resource for molecular biology, evolutionary biology, and ecology. While some attention has been drawn to sequence errors (1), common annotation errors also reduce the value of this database. In fact, for organisms...

GenMAPP 2: new features and resources for pathway analysis

Directory of Open Access Journals (Sweden)

Dahlquist Kam D

2007-06-01

Full Text Available Abstract Background Microarray technologies have evolved rapidly, enabling biologists to quantify genome-wide levels of gene expression, alternative splicing, and sequence variations for a variety of species. Analyzing and displaying these data present a significant challenge. Pathway-based approaches for analyzing microarray data have proven useful for presenting data and for generating testable hypotheses. Results To address the growing needs of the microarray community we have released version 2 of Gene Map Annotator and Pathway Profiler (GenMAPP, a new GenMAPP database schema, and integrated resources for pathway analysis. We have redesigned the GenMAPP database to support multiple gene annotations and species as well as custom species database creation for a potentially unlimited number of species. We have expanded our pathway resources by utilizing homology information to translate pathway content between species and extending existing pathways with data derived from conserved protein interactions and coexpression. We have implemented a new mode of data visualization to support analysis of complex data, including time-course, single nucleotide polymorphism (SNP, and splicing. GenMAPP version 2 also offers innovative ways to display and share data by incorporating HTML export of analyses for entire sets of pathways as organized web pages. Conclusion GenMAPP version 2 provides a means to rapidly interrogate complex experimental data for pathway-level changes in a diverse range of organisms.

Update History of This Database - GenLibi | LSDB Archive [Life Science Database Archive metadata

Lifescience Database Archive (English)

Full Text Available switchLanguage; BLAST Search Image Search Home About Archive Update History Data ...List Contact us GenLibi Update History of This Database Date Update contents 2014/03/25 GenLibi English archi...base Description Download License Update History of This Database Site Policy | Contact Us Update History of This Database - GenLibi | LSDB Archive ... ...ve site is opened. 2007/03/01 GenLibi ( http://gene.biosciencedbc.jp/ ) is opened. About This Database Data

Simulating GenCo bidding strategies in electricity markets with an agent-based model

International Nuclear Information System (INIS)

Botterud, Audun; Thimmapuram, Prakash R.; Yamakado, Malo

2005-01-01

In this paper we use an agent-based simulation model, EMCAS, to analyze market power in electricity markets. We focus on the effect of congestion management on the ability of generating companies (GenCos) to raise prices beyond competitive levels. An 11-node test power system is used to compare a market design based on locational marginal pricing with a market design that uses system marginal pricing and congestion management by counter trading. Bidding strategies based on both physical and economic withholding are compared to a base case with production cost bidding. The results show that unilateral market power is exercised under both pricing mechanisms. However, the largest changes in consumer costs and GenCo profits due to strategic bidding occur under the locational marginal pricing scheme. The analysis also illustrates that agent-based modeling can contribute important insights into the complex interactions between the participants in transmission-constrained electricity markets. (Author)

Sistema inmune y genética: un abordaje diferente a la diversidad de anticuerpos.

OpenAIRE

Matta Camacho, Nubia Estela

2011-01-01

RESUMEN Es común encontrar en los libros de inmunología o de genética un capítulo con el título de “sistema inmune y genética”, sin embargo su asociación se centra en cómo la generación de anticuerpos rompió el paradigma “un gen, una proteína”, pues en el caso de la producción de anticuerpos, un gen produce millones de proteínas. El sistema inmune tiene muchos vínculos con la genética y la herencia; esta asociación se da porque cualquier sustancia o compuesto que produzca un organi...

Dual-track CCS stakeholder engagement: Lessons learned from FutureGen in Illinois

Science.gov (United States)

Hund, G.; Greenberg, S.E.

2011-01-01

FutureGen, as originally planned, was to be the world's first coal-fueled, near-zero emissions power plant with fully integrated, 90% carbon capture and storage (CCS). From conception through siting and design, it enjoyed strong support from multiple stakeholder groups, which benefited the overall project. Understanding the stakeholder engagement process for this project provides valuable insights into the design of stakeholder programs for future CCS projects. FutureGen is one of few projects worldwide that used open competition for siting both the power plant and storage reservoir. Most site proposals were coordinated by State governments. It was unique in this and other respects relative to the site selection method used on other DOE-supported projects. At the time of site selection, FutureGen was the largest proposed facility designed to combine an integrated gasification combined cycle (IGCC) coal-fueled power plant with a CCS system. Stakeholder engagement by states and the industry consortium responsible for siting, designing, building, and operating the facility took place simultaneously and on parallel tracks. On one track were states spearheading state-wide site assessments to identify candidate sites that they wanted to propose for consideration. On the other track was a public-private partnership between an industry consortium of thirteen coal companies and electric utilities that comprised the FutureGen Alliance (Alliance) and the U.S. Department of Energy (DOE). The partnership was based on a cooperative agreement signed by both parties, which assigned the lead for siting to the Alliance. This paper describes the stakeholder engagement strategies used on both of these tracks and provides examples from the engagement process using the Illinois semi-finalist sites. ?? 2011 Published by Elsevier Ltd.

PUFF-IV, Code System to Generate Multigroup Covariance Matrices from ENDF/B-VI Uncertainty Files

International Nuclear Information System (INIS)

2007-01-01

1 - Description of program or function: The PUFF-IV code system processes ENDF/B-VI formatted nuclear cross section covariance data into multigroup covariance matrices. PUFF-IV is the newest release in this series of codes used to process ENDF uncertainty information and to generate the desired multi-group correlation matrix for the evaluation of interest. This version includes corrections and enhancements over previous versions. It is written in Fortran 90 and allows for a more modular design, thus facilitating future upgrades. PUFF-IV enhances support for resonance parameter covariance formats described in the ENDF standard and now handles almost all resonance parameter covariance information in the resolved region, with the exception of the long range covariance sub-subsections. PUFF-IV is normally used in conjunction with an AMPX master library containing group averaged cross section data. Two utility modules are included in this package to facilitate the data interface. The module SMILER allows one to use NJOY generated GENDF files containing group averaged cross section data in conjunction with PUFF-IV. The module COVCOMP allows one to compare two files written in COVERX format. 2 - Methods: Cross section and flux values on a 'super energy grid,' consisting of the union of the required energy group structure and the energy data points in the ENDF/B-V file, are interpolated from the input cross sections and fluxes. Covariance matrices are calculated for this grid and then collapsed to the required group structure. 3 - Restrictions on the complexity of the problem: PUFF-IV cannot process covariance information for energy and angular distributions of secondary particles. PUFF-IV does not process covariance information in Files 34 and 35; nor does it process covariance information in File 40. These new formats will be addressed in a future version of PUFF

KARAKTERISTIK SEKUEN cDNA PENGKODE GEN ANTI VIRUS DARI UDANG WINDU, Penaeus monodon

Directory of Open Access Journals (Sweden)

Andi Parenrengi

2016-11-01

Full Text Available Transgenesis pada ikan merupakan sebuah teknik modern yang berpotensi besar dalam menghasilkan organisme yang memiliki karakter lebih baik melalui rekombinan DNA gen target termasuk gen anti virus dalam peningkatan resistensi pada udang. Gen anti virus PmAV (Penaeus monodon Anti Viral gene merupakan salah satu gen pengkode anti virus yang berasal dari spesies krustase. Penelitian ini dilakukan untuk mengetahui karakteristik gen anti virus yang diisolasi dari udang windu, Penaeus monodon. Isolasi gen anti virus menggunakan metode Polymerase Chain Reaction (PCR dan selanjutnya dipurifikasi untuk sekuensing. Data yang dihasilkan dianalisis dengan program Genetyx Versi 7 dan basic local alignment search tool (BLAST. Hasil penelitian menunjukkan bahwa gen anti virus PmAV yang berhasil diisolasi dari cDNA udang windu dengan panjang sekuen 520 bp yang mengkodekan 170 asam amino. BLAST-N menunjukkan tingkat similaritas yang sangat tinggi (100% dengan gen anti virus yang ada di GeneBank. Komposisi asam amino penyusun gen anti virus yang paling besar adalah serin (10,00%, sedangkan yang terkecil adalah asam amino prolin dan lisin masing-masing 1,76%. Analisis sekuen gen dan deduksi asam amino (BLAST-P memperlihatkan adanya C-type lectin-like domain (CTLD yang memiliki kemiripan dengan gen C-type lectin yang diisolasi dari beberapa spesies krustase. Transgenic fish technology is a potential modern technique in producing better character organism through DNA recombinant of target genes including anti viral gene for improvement of shrimp immunity. PmAV (Penaeus monodon Anti Viral gene is one of anti viral genes isolated from crustacean species. The research was conducted to analyze the characteristics anti viral gene isolated from tiger prawn, Penaeus monodon. Anti viral gene was isolated using Polymerase Chain Reaction (PCR technique and then purified for sequencing. Data obtained were analyzed using Genetyx Version 7 software and basic local alignment

Mechanical characterization tests of the X2-Gen fuel assembly and skeleton

International Nuclear Information System (INIS)

Kim, Hyung Kyu; Yoon, Kyung Ho; Lee, Kang Hee; Kim, Jae Yong; Lee, Young Ho; Kang, Heung Seok

2011-01-01

The KNF (KEPCO Nuclear Fuel) requested mechanical characterization tests of a fuel assembly and a skeleton of the X2-Gen fuel. The tests consisted of the lateral vibration and lateral/axial stiffness, lateral/axial impact and combined deflection tests carried out by using the FAMeCT (Fuel Assembly Mechanical Characterization Tester) in KAERI. The upper and lower core plate simulators were newly designed and manufactured because the fuel geometry of the X2-Gen was different from the KSNP type fuel assembly. In addition to this, the upper carriage was also revised with the LM guide system from the previous two guide rods system. Therefore, the axial and combined deflection tests were soundly executed. Each test was repeated twice to confirm the repeatability. The discrepancy from the repetition was small enough to be neglected. The mechanical characterization tests were accredited with the KOLAS (Korea Laboratory Accreditation Scheme) standard, and the certified test reports (lateral vibration, lateral/axial bending and lateral/axial impact) and the uncertified test report (combined deflection) were issued together with the current test result report

Medicina genómica aplicada a la salud pública An overview in genomic medicine and public health

Directory of Open Access Journals (Sweden)

Ana Burguete

2009-01-01

Full Text Available La genómica, visualizada como una disciplina científica encargada del mapeo, secuenciación y análisis de los genomas, ha facilitado la identificación y comprensión de las formas de organización y función de los genes de los organismos, lo cual ha generado un amplio conocimiento de la estructura y la función de los genomas. La influencia de la genómica en la medicina ha creado una nueva visión acerca de la forma de percibir los episodios patológicos y fisiológicos, tras conocer la influencia de las variaciones genéticas sobre la susceptibilidad a la enfermedad. En la salud pública, mediante la epidemiología genética, el conocimiento genético ha promovido acciones individuales y poblacionales para evaluar el efecto de la distribución de los determinantes genéticos y su interacción con factores ambientales en la etiología de las enfermedades humanas. De modo adicional, la medicina genómica propone nuevos sistemas de diagnóstico, relaciones genéticas y alteraciones alimenticias, respuesta específica a diversos medicamentos y diseño de nuevos fármacos para grupos susceptibles. Sin embargo, los grandes avances de la medicina genómica en el campo de la salud aún son sólo promisorios.Genomics, as a scientific discipline responsible for genome maps, sequencing and functional analysis of genomes, allows for continually expanding knowledge of the structure and function of genomes. The influence of genomics on medicine generates a new perspective for how we perceive health and disease, knowing the influence of genetic variations on susceptibility to disease. In the area of public health, genetic epidemiology translates genetic knowledge into individual and public actions, evaluating the effect of the distribution of genetic determinants and their interaction with environmental factors involved in the etiology of human diseases. In addition, genomic medicine suggests new diagnostic systems, genetic associations and nutritional

Algoritmos genéticos

Directory of Open Access Journals (Sweden)

José Jesús Martínez Páez

1998-10-01

Full Text Available Esta técnica se basa en el concepto de evolución a través de selección de los mejores individuos, y de los operadores genéticos de selección, reproducción y mutación. Se trata entonces, de definir un espacio de soluciones para el problema que se quiere solucionar, en una cadena de bits. A esto se le conoce como la codificación del cromosoma, donde cada bit, denominado gen  tiene cierto significado especial. Inicialmente el algoritmo genera al azar muchas de estas cadenas o seres, es decir, una población, que luego confronta can un ambiente, que es el problema solucionar o función que se quiere optimizar. De esta confrontación  o evaluación a que se somete cada ser. Se obtiene información sobre cómo se comporto cada uno. A través de métodos aleatorios, pero con probabilidad de selección proporcional a su comportamiento, es decir, a mejor comportamiento mayor probabilidad, se selecciona una nueva población de seres supuestamente mejores que la generación anterior.

Ekspresi Gen CYP19 Aromatase, Estrogen, Androgen pada penderita Periodontitis Agresif

Directory of Open Access Journals (Sweden)

Dahlia Herawati

2016-11-01

Full Text Available Kepadatan tulang tubuh ditentukan oleh gen CYP19 aromatase, hormon estrogen dan androgen. Pada periodontitis agresif terjadi perkembangan cepat kerusakan tulang alveolar, dan kerusakan tulang alveoler tersebut tidak diimbangioleh regenerasi tulang. Tujuan penelitian ini adalah menunjukkan ekspresi gen CYP19 aromatase, estrogen, androgen pada penderita periodontitis agresif agar dapat untuk menjadi pertimbangan pada saat melakukan perawatan periodontal. Metode penelitian, pemeriksaan ekspresi gen aromatse CYP19 berasal dari spesimen tulang alveolar menggunakan imunohistokimia, pengukuran hormon estrogen dan androgen dari serum menggunakan Vidas: Elfa. Hasil penelitian ekspresi gene CYP19 aromatase pada periodontitis agresif menunjukkan gambaran lebih rendah densitasnya dibandingkan pada nonperiodontitis. Estrogen dan androgen pad aperiodontitis agresif ada kecenderungan lebih rendah dibandingkan pada nonperiodontitis. Kesimpulan regenerasi tulang alveoler pad a periodontitis agresif terhambat karena sedikitnya gen CYP19 aromatase dan hormon estrogen dan androgen yang berperan pada pembentukan tulang alveoler kurang memadai.

La genética de las poblaciones centroamericanas

OpenAIRE

Barrantes, Ramiro

2005-01-01

Las poblaciones centroamericanas no han sido objeto de muchos estudios genéticos con la excepción de análisis esporádicos de la variación entre y dentro de los grupos amerindios y de origen africano ubicados en el área. No obstante, en los últimos 15 años se efectuaron investigaciones sistemáticas en este sentido incluyendo poblaciones mestizas, particularmente las de Costa Rica y Panamá. En los amerindios se efectuaron estudios detallados de su estructura genética y las relaciones filogenéti...

Investigation of a Novel NDE Method for Monitoring Thermomechanical Damage and Microstructure Evolution in Ferritic-Martensitic Steels for Generation IV Nuclear Energy Systems

Energy Technology Data Exchange (ETDEWEB)

Nagy, Peter

2013-09-30

The main goal of the proposed project is the development of validated nondestructive evaluation (NDE) techniques for in situ monitoring of ferritic-martensitic steels like Grade 91 9Cr-1Mo, which are candidate materials for Generation IV nuclear energy structural components operating at temperatures up to ~650{degree}C and for steam-generator tubing for sodium-cooled fast reactors. Full assessment of thermomechanical damage requires a clear separation between thermally activated microstructural evolution and creep damage caused by simultaneous mechanical stress. Creep damage can be classified as "negligible" creep without significant plastic strain and "ordinary" creep of the primary, secondary, and tertiary kind that is accompanied by significant plastic deformation and/or cavity nucleation and growth. Under negligible creep conditions of interest in this project, minimal or no plastic strain occurs, and the accumulation of creep damage does not significantly reduce the fatigue life of a structural component so that low-temperature design rules, such as the ASME Section III, Subsection NB, can be applied with confidence. The proposed research project will utilize a multifaceted approach in which the feasibility of electrical conductivity and thermo-electric monitoring methods is researched and coupled with detailed post-thermal/creep exposure characterization of microstructural changes and damage processes using state-of-the-art electron microscopy techniques, with the aim of establishing the most effective nondestructive materials evaluation technique for particular degradation modes in high-temperature alloys that are candidates for use in the Next Generation Nuclear Plant (NGNP) as well as providing the necessary mechanism-based underpinnings for relating the two. Only techniques suitable for practical application in situ will be considered. As the project evolves and results accumulate, we will also study the use of this technique for monitoring other GEN IV

The carbonate complexation of plutonium(IV)

International Nuclear Information System (INIS)

Hobart, D.E.; Palmer, P.D.; Newton, T.W.

1985-01-01

Plutonium(IV) carbonate complexes are expected to be of particular importance in typical groundwaters at the Yucca Mountain site of the candidate nuclear waste repository being studied by the Nevada Nuclear Waste Storage Investigations Project. The chemistry of these complexes is also important in the areas of nuclear fuel reprocessing and purification, actinide separations, and environmental studies. This report describes initial experiments performed to determine the identity and equilibrium quotients of plutonium(IV) carbonate complexes. These experiments were performed at pH values between 7.2 and 9.6 using a spectrophotometric method. In addition, a brief review of the published literature on Pu(IV) carbonate complexes is presented. Since Pu(IV) exhibits low solubility in the near-neutral pH range, a complex-competition reaction where citrate ligands compete with carbonate ions for the plutonium will be employed. This will permit us to study the pure carbonate system; study the mixed carbonate/citrate system, and confirm and extend the literature work on the pure citrate system. The current experiments have demonstrated the existence of at least three distinct species in the pH region studied. This work will continue in the extended study of the pure citrate system, followed by the investigation of the citrate/carbonate complex/competition reaction. 9 refs., 4 figs., 2 tabs

Electrochemistry and Spectroelectrochemistry of the Pu (III/IV) and (IV/VI) Couples in Nitric Acid Systems

Energy Technology Data Exchange (ETDEWEB)

Lines, Amanda M. [Nuclear Chemistry and Engineering, Pacific Northwest National Laboratory, Richland WA 99352; Adami, Susan R. [Nuclear Chemistry and Engineering, Pacific Northwest National Laboratory, Richland WA 99352; Casella, Amanda J. [Nuclear Chemistry and Engineering, Pacific Northwest National Laboratory, Richland WA 99352; Sinkov, Sergey I. [Nuclear Chemistry and Engineering, Pacific Northwest National Laboratory, Richland WA 99352; Lumetta, Gregg J. [Nuclear Chemistry and Engineering, Pacific Northwest National Laboratory, Richland WA 99352; Bryan, Samuel A. [Nuclear Chemistry and Engineering, Pacific Northwest National Laboratory, Richland WA 99352

2017-09-20

The solution chemistry of Pu in nitric acid is explored via electrochemistry and spectroelectrochemistry. By utilizing and comparing these techniques, an improved understanding of Pu behavior and its dependence on nitric acid concentration can be achieved. Here the Pu (III/IV) couple is characterized using cyclic voltammetry, square wave voltammetry, and a spectroelectrochemical Nernst step. Results indicate the formal reduction potential of the couple shifts negative with increasing acid concentration and reversible electrochemistry is no longer attainable above 6 M HNO3. Spectroelectrochemistry is also used to explore the irreversible oxidation of Pu(IV) to Pu(VI) and shine light on the mechanism and acid dependence of the redox reaction.

Traffic Generator (TrafficGen) Version 1.4.2: Users Guide

Science.gov (United States)

2016-06-01

the network with Transmission Control Protocol and User Datagram Protocol Internet Protocol traffic. Each node generating network traffic in an...TrafficGen Graphical User Interface (GUI) 3 3.1 Anatomy of the User Interface 3 3.2 Scenario Configuration and MGEN Files 4 4. Working with...for public release; distribution is unlimited. vi List of Figures Fig. 1 TrafficGen user interface

Quantificação da divergência genética entre acessos de goibeira por meio da estratégia Ward-MLM

Directory of Open Access Journals (Sweden)

Bianca Machado Campos

2013-06-01

Full Text Available O presente trabalho teve como objetivo quantificar a divergência genética entre 138 acessos de goiabeira procedentes do banco de germoplasma da Universidade Estadual do Norte Fluminense Darcy Ribeiro (UENF, com base em descritores morfológicos, agronômicos e físico-químicos, por meio do procedimento Ward - Modified Location Model (MLM. Para tanto, foram avaliados 13 descritores, sendo cinco qualitativos (coloração da polpa, superfície do fruto, formato do fruto ao final do pedúnculo, largura do pescoço e uniformidade da cor da polpa e oito quantitativos (massa média do fruto, diâmetro longitudinal do fruto, diâmetro transversal do fruto, rendimento da polpa, teor de sólidos solúveis totais, acidez do fruto, relação teor de sólidos solúveis totais e acidez do fruto e teor de ácido ascórbico. Detectou-se ampla variabilidade genética pelos dados morfológicos, agronômicos e físico-químicos nos 138 acessos de goiaba. Pelo procedimento da função da verossimilhança, determinou-se oito o número ideal de grupos, com um valor de incremento de 67,51. O grupo III foi considerado o mais distante, enquanto os grupos I, II, IV, V e VI, os mais próximos. O procedimento Ward-MLM é uma ferramenta útil para detectar divergência genética e agrupar os acessos utilizando, simultaneamente, variáveis qualitativas e quantitativas.

A Feasibility Study on the Application of the ScriptGenE Framework as an Anomaly Detection System in Industrial Control Systems

Science.gov (United States)

2015-09-17

protocol xii TN true negative TP true positive TNR true negative rate TPR true positive rate UDP user datagram protocol UPGMA unweighted pair group method...Smith-Waterman, Needleman-Wunsch and tree creation via unweighted pair group method with arithmetic mean ( UPGMA ) clustering. ScriptGen extends PI by using

Polygonal Prism Mesh in the Viscous Layers for the Polyhedral Mesh Generator, PolyGen

International Nuclear Information System (INIS)

Lee, Sang Yong; Park, Chan Eok; Kim, Shin Whan

2015-01-01

Polyhedral mesh has been known to have some benefits over the tetrahedral mesh. Efforts have been made to set up a polyhedral mesh generation system with open source programs SALOME and TetGen. The evaluation has shown that the polyhedral mesh generation system is promising. But it is necessary to extend the capability of the system to handle the viscous layers to be a generalized mesh generator. A brief review to the previous works on the mesh generation for the viscous layers will be made in section 2. Several challenging issues for the polygonal prism mesh generation will be discussed as well. The procedure to generate a polygonal prism mesh will be discussed in detail in section 3. Conclusion will be followed in section 4. A procedure to generate meshes in the viscous layers with PolyGen has been successfully designed. But more efforts have to be exercised to find the best way for the generating meshes for viscous layers. Using the extrusion direction of the STL data will the first of the trials in the near future

TRANSFER GEN ANTIVIRUS PADA EMBRIO UDANG WINDU, Penaeus monodon DALAM BERBAGAI KONSENTRASI DEOXYRIBO NUCLEIC ACID

Directory of Open Access Journals (Sweden)

Andi Parenrengi

2011-12-01

Full Text Available Teknologi transgenesis khususnya rekayasa genetik untuk menghasilkan udang windu resisten penyakit merupakan salah satu strategi yang dapat dilakukan dalam upaya pemecahan masalah penyakit yang menimpa budidaya udang windu. Teknologi transgenesis khususnya transfer gen antivirus pada udang windu telah berhasil dilakukan melalui teknik transfeksi. Meskipun demikian optimalisasi komponen teknologi tersebut masih perlu dilakukan. Konsentrasi DNA gen merupakan salah satu komponen teknologi transgenesis yang harus dioptimalkan untuk mendapatkan efisiensi dalam transfer gen. Penelitian bertujuan untuk mengetahui konsentrasi DNA gen antivirus yang optimal sebagai bahan transfer gen ke embrio menggunakan metode transfeksi. Embrio udang windu yang diperoleh dari hasil pemijahan induk asal Aceh, dikoleksi 5-10 menit setelah memijah dengan kepadatan 625 telur/2 mL. Transfeksi dilakukan dengan menggunakan media larutan transfeksi jetPEI dengan konsentrasi DNA gen antivirus sebagai perlakuan, yakni: 5, 10, dan 15 µg serta kontrol positif (tanpa plasmid DNA dan negatif (tanpa plasmid DNA dan larutan transfeksi, masing-masing 3 ulangan. Embrio hasil transfeksi ditetaskan pada stoples berisi air laut sebanyak 2 L yang diletakkan pada waterbath. Hasil penelitian menunjukkan bahwa gen antivirus telah berhasil diintroduksi ke embrio udang windu. Hasil analisis ragam menunjukkan bahwa perbedaan konsentrasi DNA (5-15 µg tidak berpengaruh nyata (P>0,05 terhadap daya tetas embrio udang windu. Analisis ekspresi gen pada larva udang windu juga menunjukkan adanya aktivitas ekspresi gen antivirus pada semua perlakuan konsentrasi DNA, di mana ekspresi gen antivirus pada larva transgenik lebih tinggi dibandingkan dengan kontrol (tanpa transfeksi. Sintasan pasca-larva PL-1 yang didapatkan pada penelitian ini adalah 12,0%; 10,0%; 10,6%; 12,3%; dan 14,2% masing-masing untuk perlakuan konsentrasi plasmid DNA 5 µg, 10 µg, 15 µg, kontrol positif dan negatif, di mana

Mejoramiento genético acelerado de angiospermas perennes vía inducción floral por sobre-expresión del gen FT

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Rafael Urrea López

2018-05-01

Full Text Available Los bosques y selvas enfrentan el reto de satisfacer la demanda por recursos de una población en crecimiento, así como la amenaza del rápido cambio climático que exacerba la magnitud y frecuencia de estreses bióticos y abióticos. Para ello, es urgente acelerar el mejoramiento genético de especies forestales. Sin embargo, sus largas etapas juveniles y asincronía floral retrasan peligrosamente este proceso. El presente ensayo explora los adelantos biotecnológicos en inducción floral y su potencial aplicación en especies forestales. Entre los genes identificados y caracterizados que participan en la ruta de señalización de la floración, especial atención se destina al gen FLOWERING LOCUS T, considerado un integrador de rutas de señalización altamente conservado entre las angiospermas, que, al sobre-expresarse por ingeniería genética, es capaz de inducir la floración de forma eficiente. Esta novedosa estrategia biotecnológica se ha utilizado, recientemente, para segregar genes de resistencia a enfermedades, en un menor tiempo, en germoplasma comercial de manzana y ciruela. Permite soslayar barreras naturales que por mucho tiempo han restringido a las especies forestales al mejoramiento por selección, principalmente. Entre sus ventajas está la de poder restringirla al proceso y no al producto, para acelerar las cruzas sexuales sin modificar genéticamente la progenie; se aleja así de la controversia alrededor de la liberación y consumo de organismos genéticamente modificados, y de los costos y trámites obligatorios para los OGM para monitoreo de posibles riesgos. Se proyecta como una tecnología que puede acelerar, significativamente, el mejoramiento de especies forestales.

Aconselhamento genético Genetic counseling

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João Monteiro de Pina-Neto

2008-08-01

Full Text Available OBJETIVO: Esta revisão sobre aconselhamento genético (AG teve o objetivo de mostrar os conceitos atuais e os princípios filosóficos e éticos aceitos na grande maioria dos países e recomendados pela Organização Mundial da Saúde, as fases do processo, seus resultados e o impacto psicológico de uma doença genética em uma família. FONTES DOS DADOS: Os conceitos apresentados são baseados em uma síntese histórica da literatura sobre AG desde a década de 1930 até o momento atual, sendo que os artigos citados representam os principais trabalhos publicados e que hoje fundamentam a teoria e a prática do AG. SÍNTESE DOS DADOS: O AG modernamente é definido como um processo de comunicação que trata dos problemas humanos relacionados à ocorrência de uma doença genética em uma família. É fundamental que os profissionais da saúde conheçam os aspectos psicológicos desencadeados pela doença genética e como estes aspectos podem ser manejados. Vivemos ainda na genética humana e médica uma fase de predomínio dos aspectos técnicos e científicos e de pouca ênfase no estudo das reações emocionais e dos processos de adaptação das pessoas a estas doenças, o que leva ao baixo entendimento dos clientes sobre os fatos ocorridos, com conseqüências negativas sobre a vida familiar e para a sociedade. CONCLUSÕES: Conclui-se pela necessidade de que as famílias com doenças genéticas sejam encaminhadas para AG e que os profissionais desta área invistam mais na humanização do atendimento, desenvolvendo mais as técnicas do AG psicológico não-diretivo.OBJECTIVE: The objective of this review of genetic counseling (GC is to describe the current concepts and philosophical and ethical principles accepted by the great majority of countries and recommended by the World Health Organization, the stages of the process, its results and the psychological impact that a genetic disease has on a family. SOURCES: The concepts presented are

Estudio de la variabilidad genética en camélidos bolivianos

OpenAIRE

Barreta Pinto, Julia

2013-01-01

El estudio de los camélidos sudamericanos es de gran interés en los países andinoscomo Perú, Bolivia, Chile, Argentina, debido a su importante valor económico y suimportancia en el mantenimiento y desarrollo de las poblaciones rurales en dichos países. Dada la falta de estudios genéticos centrados en las poblaciones de camélidos quehabitan en Bolivia, y la necesidad de realizar una valoración de la diversidad genética deestas poblaciones, la presente Tesis doctoral ha abordado el estudio gené...

A comparison of outcomes according to different diagnostic systems for delirium (DSM-5, DSM-IV, CAM, and DRS-R98).

Science.gov (United States)

Adamis, Dimitrios; Meagher, David; Rooney, Siobhan; Mulligan, Owen; McCarthy, Geraldine

2018-04-01

ABSTRACTStudies indicate that DSM-5 criteria for delirium are relatively restrictive, and identify different cases of delirium compared with previous systems. We evaluate four outcomes of delirium (mortality, length of hospital stay, institutionalization, and cognitive improvement) in relation to delirium defined by different DSM classification systems.Prospective, longitudinal study of patients aged 70+ admitted to medical wards of a general hospital. Participants were assessed up to a maximum of four times during two weeks, using DSM-5 and DSM-IV criteria, DRS-R98 and CAM scales as proxies for DSM III-R and DSM III.Of the 200 assessed patients (mean age 81.1, SD = 6.5; and 50% female) during hospitalization, delirium was identified in 41 (20.5%) using DSM-5, 45 (22.5%) according to DSM-IV, 46 (23%) with CAM positive, and 37 (18.5%) with DRS-R98 severity score >15. Mortality was significantly associated with delirium according to any classification system, but those identified with DSM-5 were at greater risk. Length of stay was significantly longer for those with DSM-IV delirium. Discharge to a care home was associated only with DRS-R98 defined delirium. Cognitive improvement was only associated with CAM and DSM-IV. Different classification systems for delirium identify populations with different outcomes.

Mitigation of severe accidents in AREVA's Gen 3+ nuclear power plants

Energy Technology Data Exchange (ETDEWEB)

Fischer, M., E-mail: manfred.fischer@areva.com; Henning, A.; Surmann, R.

2014-04-01

The current AREVA Gen 3+ PWR designs (EPR™ and ATMEA1) are based on the proven defense-in-depth safety concepts inherited from their predecessors, the French “N4” and the German “Konvoi” reactors. Complemented by specific enhancements, including higher redundancy and diversity as well as the use of passive systems, this leads to very low values of the core damage frequency (CDF). Notwithstanding this very low probability, dedicated design measures have been implemented to improve the response of the plant in case of a postulated severe accident (SA) with core melting. This way not only the frequency of large-early-releases (LERF) but also the related radiological consequences are drastically reduced. Situations that potentially lead to high loads that can challenge the short-term integrity of the containment, like RPV melt-through under high pressure, energetic hydrogen/steam explosions, as well as long-term containment failure caused by internal over-pressure are avoided by a combination of preventive measures and dedicated systems. At the example of the EPR{sup TM}, the paper gives an overview of the severe accident mitigation strategy and the related measures and systems of AREVAs current Gen 3+ reactors, with special focus on the function of the core melt stabilization system.

Preparation, spectrometric analysis and determination of the electrochemical transport characteristics of uranium (IV) in aqueous systems

International Nuclear Information System (INIS)

Schwarzer, W.G.

1985-01-01

A process for the quantitative development of uranium-(IV) solutions in nitric and perchloric acid media was developed. After appropriate concentration setting of the solutions, the conductivity of the uranium (IV) in the dependence on concentration were analysed. The conversion of the measuring results on the standard system water was done by means of a conductivity theory; this allows a comparison with the conductivity data of other ions. The conductivity calculated, at an ion strength I tending to zero, provided the suitable data for the ion mobility and the transference number. (orig./PW) [de

A simple Cr(VI)–S(IV)–O{sub 2} system for rapid and simultaneous reduction of Cr(VI) and oxidative degradation of organic pollutants

Energy Technology Data Exchange (ETDEWEB)

Yuan, Yanan; Yang, Shaojie [Department of Environmental Science, Hubei Key Lab of Biomass Resource Chemistry and Environmental Biotechnology, School of Resources and Environmental Science, Wuhan University, 430079 (China); Zhou, Danna, E-mail: zdncug@163.com [Faculty of Material Science and Chemistry, China University of Geosciences, Wuhan 430074 (China); Wu, Feng [Department of Environmental Science, Hubei Key Lab of Biomass Resource Chemistry and Environmental Biotechnology, School of Resources and Environmental Science, Wuhan University, 430079 (China)

2016-04-15

Highlights: • Rapid and simultaneous reduction of Cr(VI) and degradation of organic pollutants occur. • Oxysulfur radicals generated in Cr(VI)–S(IV)–O{sub 2} system oxidize the organic pollutants. • Acidic pH facilitates the reactions from both directions of reduction and oxidation. • Degradation potential of aromatic amines depends on the substituted groups. • Cr(VI)–S(IV)–O{sub 2} system is promising for “waste control by waste”. - Abstract: Hexavalent chromium (Cr(VI)), a heavy-metal contaminant, can be easily reduced to less toxic trivalent chromium (Cr(III)) by sulfite ions (S(IV)). However, S(IV) has not drawn as much attention as the ferrous ion has. We report herein a novel Cr(VI)–S(IV)–O{sub 2} system containing sulfite ions that rapidly and simultaneously reduces Cr(VI) and oxidize organic pollutants in the presence of oxygen in aqueous solutions. This Cr(VI)–S(IV)-O{sub 2} system contains the initiator Cr(VI), the reductant S(IV), and the oxidant O{sub 2}, which produce oxysulfur radicals (mainly SO{sub 4}·{sup −} and SO{sub 5}·{sup −}) and hydroxyl radicals (OH·). The Cr(VI)/S(IV) molar ratio, pH, and oxygen content play important roles in the entire reaction system. Acidic conditions (pH 3.0) facilitated degradation of organic compounds and reduction of Cr(VI) as well. In addition, experiments of rapid degradation of several kinds of organic pollutants such as azo dye (acid orange 7, AO7), aniline, phenol, bisphenol A etc were also conducted. Preliminary results show that the removal rates of the analogs of phenols or aromatic amines in this Cr(VI)–S(IV)–O{sub 2} system have a relationship with the electronic parameters (Hammett constant, σ) of the substituted groups. Thus, the Cr(VI)–S(IV)–O{sub 2} system, provides an excellent strategy of “waste control by waste” for removing multiple industrial contaminants.

O futuro da epidemiologia genética de características complexas

Directory of Open Access Journals (Sweden)

Feitosa Mary F.

2002-01-01

Full Text Available A epidemiologia genética evoluiu de um enfoque em estudos sobre doenças mendelianas raras para a análise genética de características complexas. Com o advento de informações sobre a completa seqüência de genes ao longo do genoma humano e de outros organismos, o interesse da epidemiologia genética em desvendar a natureza dos fatores que influenciam essas características se tornou primordial. São apresentados os principais métodos empregados no estudo de doenças complexas bem como suas principais vantagens e desvantagens. Discute-se a importância na determinação da amostra e o uso de fenótipos e marcadores genéticos apropriados. Como exemplo das estratégias citadas tomamos o estudo de índice de massa corporal (BMI para ilustrar um fator genético principal localizado no cromossomo 7. Em uma discussão sobre tendências no estudo de ligação, embora reconhecendo que famílias e genealogias continuarão sendo o foco principal das amostras, discute-se alguns novos e eficientes tipos de amostragem (como por exemplo, controles não-relacionados em que amostras de conjunto de DNA serão universalmente empregadas. O reconhecimento da heterogeneidade genética entre estudos e sua interpretação será uma das mais importantes características no futuro das análises de características complexas.

Doping Genético e Eugenia: Diálogos além do esporte

Directory of Open Access Journals (Sweden)

Tiago Vieira Bomtempo

2016-01-01

Full Text Available La ingeniería genética trajo posibilidades antes inimaginables, en la que no hace mucho tiempo era visto sólo en las películas. De la terapia génica, dirigida hacia una corrección o cura de una enfermedad, pasa a la posibilidad del mejoramiento genético, actualmente vislumbrado en el mundo del deporte con el doping genético. ¿Pero, el doping genético no estaría violando el derecho al patrimonio genético no modificado? Aunque la intervención genética no se transmita a los descendentes, habría un mejoramiento genético, que afectaría el genoma del atleta y lo diferenciaría de los demás atletas y otros individuos, hiriendo el principio de igualdad en detrimento de la autonomía privada, pudiéndose estar hablando inicialmente de una relación de dominación, aunque sea en razón al rendimiento físico en el deporte. En este sentido, estas innovaciones que atraviesan el campo de la ingeniería genética, infunden una preocupación acerca de la manipulación genética en las generaciones futuras, punto de discusión no sólo biomédica, sino también bioético y biojurídico. Así, surge una preocupación si estos nuevos avances pueden afectar a la dignidad humana delante de una posible eugenesia, debido a la proyección de personas y la consecuente discriminación por determinada identidad genética. Junto a esto, el objetivo de este artículo es investigar si el dopaje genético ofendería el derecho al patrimonio genético no modificado y los derechos de las generaciones futuras, dando lugar a una nueva forma de eugenesia, al no permitir el ejercicio igualitario de las libertades fundamentales. Por lo tanto, se hace necesaria una investigación basada en los autores de la bioética y el bioderecho, así como también los textos legales nacionales e internacionales que involucran el tema. Es indispensable la discusión de estas cuestiones, sobre todo con la proximidad de los Juegos Olímpicos de Verano en Brasil en este año 2016

Microsatélites, distancias genéticas y estructura de poblaciones nativas sudamericanas

Directory of Open Access Journals (Sweden)

Demarchi, Darío Alfredo

2009-01-01

Full Text Available En este trabajo se investigaron las relaciones genéticas entre 17 poblaciones nativas sudamericanas en relación a 15 microsatélites (STRs autosómicos, utilizando 3 distancias genéticas- DST, DAy (δu2-que se ajustan a diferentes postulados teóricos. A través de diferentes técnicas de análisis (escalamiento multidimensional, correlación y correlación parcial de matrices se puso a prueba si las distancias genéticas reflejaban las relaciones interpoblacionales esperadas a partir de la distribución geográfica o de relaciones lingüísticas entre las poblaciones. Además, se estimó en que grado las distintas medidas de distancias genéticas eran influenciadas por la diversidad (He de cada población. Los mapas genéticos muestran, principalmente para DST y DA, que las poblaciones aisladas y con bajo tamaño efectivo (Ne aparecen como outliers, mientras que las poblaciones con alto Ne y mayor flujo génico ocupan una posición central a bajos valores de distancia unas de otras y sin un patrón definido de agrupamiento. La falta de asociación entre distancias genéticas y lingüísticas o geográficas y por otra parte, la alta correlación negativa entre He y distancias génicas promedio por población confiman ese patrón, demostrando que la mayor parte de la variación interpoblacional puede ser explicada en función del grado de diversidad intrapoblacional. Es decir, las distancias genéticas no reflejan relaciones filogenéticas, lingüísticas o geográficas, sino más bien eventos demográficos recientes tales como cuellos de botella genético, efecto fundador o migración externa masiva. Este hecho puede ser comprobado por medio de otra metodología analítica, el modelo de Harpending y Ward.

Meeting Air Transportation Demand in 2025 by Using Larger Aircraft and Alternative Routing to Complement NextGen Operational Improvements

Science.gov (United States)

Smith, Jeremy C.; Guerreiro, Nelson M.; Viken, Jeffrey K.; Dollyhigh, Samuel M.; Fenbert, James W.

2010-01-01

A study was performed that investigates the use of larger aircraft and alternative routing to complement the capacity benefits expected from the Next Generation Air Transportation System (NextGen) in 2025. National Airspace System (NAS) delays for the 2025 demand projected by the Transportation Systems Analysis Models (TSAM) were assessed using NASA s Airspace Concept Evaluation System (ACES). The shift in demand from commercial airline to automobile and from one airline route to another was investigated by adding the route delays determined from the ACES simulation to the travel times used in the TSAM and re-generating new flight scenarios. The ACES simulation results from this study determined that NextGen Operational Improvements alone do not provide sufficient airport capacity to meet the projected demand for passenger air travel in 2025 without significant system delays. Using larger aircraft with more seats on high-demand routes and introducing new direct routes, where demand warrants, significantly reduces delays, complementing NextGen improvements. Another significant finding of this study is that the adaptive behavior of passengers to avoid congested airline-routes is an important factor when projecting demand for transportation systems. Passengers will choose an alternative mode of transportation or alternative airline routes to avoid congested routes, thereby reducing delays to acceptable levels for the 2025 scenario; the penalty being that alternative routes and the option to drive increases overall trip time by 0.4% and may be less convenient than the first-choice route.

Genetic similarity between coriander genotypes using ISSR markers Similaridade genética entre genótipos de coentro por marcadores ISSR

Directory of Open Access Journals (Sweden)

Roberto de A Melo

2011-12-01

Full Text Available With the development of new cultivars, a precise genetic characterization is essential for improvement programs or for cultivar registration and protection. Molecular markers have been complementing the traditional morphological and agronomic characterization techniques because they are virtually unlimited, cover the whole genome and are not environmentally influenced. Genetic characterization constitutes the basis for studies involving estimates of genetic similarity. Therefore, the objective of the present study was to evaluate the genetic similarity between ten coriander genotypes (nine cultivars and one line using ISSR markers. The cultivars used were: Americano, Asteca, Palmeira, Português, Santo, Supéria, Tabocas, Tapacurá, Verdão and the experimental line HTV-9299. The genetic similarity between the cultivars was estimated using 227 banded regions of ISSR molecular markers. The UBC 897 oligonucleotide generated the highest number of fragments (16, resulting in a higher polymorphism. The results indicate that the twenty-nine oligonucleotides chosen were satisfactory for detecting polymorphism. Based on the grouping analysis determined from the similarity data, there were two groups and two sub-groups. The calculated similarity for the genotypes varied from 52 to 75%. The lowest similarity was observed between Português and Verdão, at 52%. The highest similarity was found between Português and Palmeira, at 75%. The ISSR is efficient for identifying DNA polymorphism in coriander.Com o surgimento de novas cultivares, uma caracterização genética precisa é essencial, visando à utilização em programas de melhoramento ou para fins de registros e ou proteção de cultivares. Marcadores moleculares vêm complementando a caracterização morfológica e agronômica tradicional, uma vez que são virtualmente ilimitados, cobrem todo o genoma e não são influenciados pelo ambiente. A caracterização genética constitui a base para

Control Rod Withdrawal Events Analyses for the Prototype Gen-IV SFR

Energy Technology Data Exchange (ETDEWEB)

Choi, Chiwoong; Ha, Kwiseo; Jeong, Taekyeong; Jeong, Jaeho; Chang, Wonpyo; Lee, Seungwon; An, Sangjun; Lee, Kwilim [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

2016-10-15

To confirm the limiting condition, based on the maximum allowable reactivity insertion of 0.3 $, three cases from the end of cycle (EOC) are selected. In addition, assuming the failure of CRSS by earthquake, additional cases is defined at beginning of cycle (BOC). When the CRW occurs, the reactor can be protected by plant protection system (PPS). In this study, PPS mechanism is sequentially studied for all initiating events. For design basis accidents (DBA), the reactor can be scrammed by reactor protection system (RPS). The first and seconds RPS signals are checked during transients. When RPS is failed, so called as anticipated transient without scram (ATWS), the reactor will be protected by diverse protection system (DPS). In this study, in order to analyze various initiating events related control rod withdrawal, four kinds of operating condition is defined. TOP events are analyzed using MARS-LMR. The influence of various plant protection system such as RPS and DPS are investigated.

X-Band Electron Paramagnetic Resonance Comparison of Mononuclear Mn(IV)-oxo and Mn(IV)-hydroxo Complexes and Quantum Chemical Investigation of Mn(IV) Zero-Field Splitting.

Science.gov (United States)

Leto, Domenick F; Massie, Allyssa A; Colmer, Hannah E; Jackson, Timothy A

2016-04-04

X-band electron paramagnetic resonance (EPR) spectroscopy was used to probe the ground-state electronic structures of mononuclear Mn(IV) complexes [Mn(IV)(OH)2(Me2EBC)](2+) and [Mn(IV)(O)(OH)(Me2EBC)](+). These compounds are known to effect C-H bond oxidation reactions by a hydrogen-atom transfer mechanism. They provide an ideal system for comparing Mn(IV)-hydroxo versus Mn(IV)-oxo motifs, as they differ by only a proton. Simulations of 5 K EPR data, along with analysis of variable-temperature EPR signal intensities, allowed for the estimation of ground-state zero-field splitting (ZFS) and (55)Mn hyperfine parameters for both complexes. From this analysis, it was concluded that the Mn(IV)-oxo complex [Mn(IV)(O)(OH)(Me2EBC)](+) has an axial ZFS parameter D (D = +1.2(0.4) cm(-1)) and rhombicity (E/D = 0.22(1)) perturbed relative to the Mn(IV)-hydroxo analogue [Mn(IV)(OH)2(Me2EBC)](2+) (|D| = 0.75(0.25) cm(-1); E/D = 0.15(2)), although the complexes have similar (55)Mn values (a = 7.7 and 7.5 mT, respectively). The ZFS parameters for [Mn(IV)(OH)2(Me2EBC)](2+) were compared with values obtained previously through variable-temperature, variable-field magnetic circular dichroism (VTVH MCD) experiments. While the VTVH MCD analysis can provide a reasonable estimate of the magnitude of D, the E/D values were poorly defined. Using the ZFS parameters reported for these complexes and five other mononuclear Mn(IV) complexes, we employed coupled-perturbed density functional theory (CP-DFT) and complete active space self-consistent field (CASSCF) calculations with second-order n-electron valence-state perturbation theory (NEVPT2) correction, to compare the ability of these two quantum chemical methods for reproducing experimental ZFS parameters for Mn(IV) centers. The CP-DFT approach was found to provide reasonably acceptable values for D, whereas the CASSCF/NEVPT2 method fared worse, considerably overestimating the magnitude of D in several cases. Both methods were poor in

Crystal Structure of a Eukaryotic GEN1 Resolving Enzyme Bound to DNA

Directory of Open Access Journals (Sweden)

Yijin Liu

2015-12-01

Full Text Available We present the crystal structure of the junction-resolving enzyme GEN1 bound to DNA at 2.5 Å resolution. The structure of the GEN1 protein reveals it to have an elaborated FEN-XPG family fold that is modified for its role in four-way junction resolution. The functional unit in the crystal is a monomer of active GEN1 bound to the product of resolution cleavage, with an extensive DNA binding interface for both helical arms. Within the crystal lattice, a GEN1 dimer interface juxtaposes two products, whereby they can be reconnected into a four-way junction, the structure of which agrees with that determined in solution. The reconnection requires some opening of the DNA structure at the center, in agreement with permanganate probing and 2-aminopurine fluorescence. The structure shows that a relaxation of the DNA structure accompanies cleavage, suggesting how second-strand cleavage is accelerated to ensure productive resolution of the junction.

Project planning of Gen-IV sodium cooled fast reactor technology

Energy Technology Data Exchange (ETDEWEB)

Yoo, Jaewoon; Joo, H. K.; Cho, C. H.; Kim, Y. G.; Lee, D. U.; Jin, M. W.

2013-05-15

The project program will be established to shorten the design schedule by sharing the design man power and experimental facility, and by introducing the proven technology through international collaboration and the project plan including preliminary specific design, technology validation and fuel design validation plan will be more detail by reviewing the plan at the International Technical Review Meeting (ITRM). Periodic project progress review meeting will be held to find the technical issues and to resolve them. The results of the progress review meeting will be reflected into the final assessment of research project. The project progress review meeting will be held every quarter and external expert will also participate in the meeting. In parallel with the PGSFR development, innovative small modular SFR will be developed aiming to the international nuclear market. The system and component technologies of both system can be shared but innovative concept will be implemented into the design. Ultra long life core design concept and supercritical CO{sub 2} Brayton cycle will be considered as the innovative concept for enhancing the plant economy and safety.

Project planning of Gen-IV sodium cooled fast reactor technology

International Nuclear Information System (INIS)

Yoo, Jaewoon; Joo, H. K.; Cho, C. H.; Kim, Y. G.; Lee, D. U.; Jin, M. W.

2013-05-01

The project program will be established to shorten the design schedule by sharing the design man power and experimental facility, and by introducing the proven technology through international collaboration and the project plan including preliminary specific design, technology validation and fuel design validation plan will be more detail by reviewing the plan at the International Technical Review Meeting (ITRM). Periodic project progress review meeting will be held to find the technical issues and to resolve them. The results of the progress review meeting will be reflected into the final assessment of research project. The project progress review meeting will be held every quarter and external expert will also participate in the meeting. In parallel with the PGSFR development, innovative small modular SFR will be developed aiming to the international nuclear market. The system and component technologies of both system can be shared but innovative concept will be implemented into the design. Ultra long life core design concept and supercritical CO 2 Brayton cycle will be considered as the innovative concept for enhancing the plant economy and safety

Thermodynamic properties of actinide complexes. IV. Thorium(IV)- and uranyl(VI)-malonate systems

Energy Technology Data Exchange (ETDEWEB)

Di Bernardo, P; Di Napoli, V; Cassol, A; Magon, L [Consiglio Nazionale delle Ricerche, Padua (Italy). Lab. di Chimica e Tecnologia dei Radioelementi

1977-01-01

The stability constants and the enthalpies of formation of thorium(IV)- and uranyl(VI)-malonate complexes have been determined by potentiometric and calorimetric titrations in 1.00 M solutions of Na(ClO/sub 4/) at 25/sup 0/C. All complexes formed are found to be stabilized by a large entropy gain. The values for the stability constants agree with an ionic bonding model. The malonate behaves as a bidentate ligand forming only chelate complexes.

GenMapDB: a database of mapped human BAC clones

OpenAIRE

Morley, Michael; Arcaro, Melissa; Burdick, Joshua; Yonescu, Raluca; Reid, Thomas; Kirsch, Ilan R.; Cheung, Vivian G.

2001-01-01

GenMapDB (http://genomics.med.upenn.edu/genmapdb) is a repository of human bacterial artificial chromosome (BAC) clones mapped by our laboratory to sequence-tagged site markers. Currently, GenMapDB contains over 3000 mapped clones that span 19 chromosomes, chromosomes 2, 4, 5, 9–22, X and Y. This database provides positional information about human BAC clones from the RPCI-11 human male BAC library. It also contains restriction fragment analysis data and end sequen...

Biomek®-3000 and GenPlex in Forensic Genetics

DEFF Research Database (Denmark)

Stangegaard, Michael; Tomas Mas, Carmen; Hansen, Anders Johannes

  SNP genotyping provides a supplement for conventional STR-based kits currently used for human identification. GenPlex (Applied Biosystems) is a SNP genotyping kit based on a multiplex of 48 informative, autosomal SNPs from the SNPforID Consortium. Our objective was to setup, implement and valid...... extension system. Full concordance of the results was obtained in all but one sample.   The results demonstrate that the Biomek-3000 can perform a series of complex reactions leading to highly consistent forensic genetic SNP typing results....

ClinGen Pathogenicity Calculator: a configurable system for assessing pathogenicity of genetic variants.

Science.gov (United States)

Patel, Ronak Y; Shah, Neethu; Jackson, Andrew R; Ghosh, Rajarshi; Pawliczek, Piotr; Paithankar, Sameer; Baker, Aaron; Riehle, Kevin; Chen, Hailin; Milosavljevic, Sofia; Bizon, Chris; Rynearson, Shawn; Nelson, Tristan; Jarvik, Gail P; Rehm, Heidi L; Harrison, Steven M; Azzariti, Danielle; Powell, Bradford; Babb, Larry; Plon, Sharon E; Milosavljevic, Aleksandar

2017-01-12

The success of the clinical use of sequencing based tests (from single gene to genomes) depends on the accuracy and consistency of variant interpretation. Aiming to improve the interpretation process through practice guidelines, the American College of Medical Genetics and Genomics (ACMG) and the Association for Molecular Pathology (AMP) have published standards and guidelines for the interpretation of sequence variants. However, manual application of the guidelines is tedious and prone to human error. Web-based tools and software systems may not only address this problem but also document reasoning and supporting evidence, thus enabling transparency of evidence-based reasoning and resolution of discordant interpretations. In this report, we describe the design, implementation, and initial testing of the Clinical Genome Resource (ClinGen) Pathogenicity Calculator, a configurable system and web service for the assessment of pathogenicity of Mendelian germline sequence variants. The system allows users to enter the applicable ACMG/AMP-style evidence tags for a specific allele with links to supporting data for each tag and generate guideline-based pathogenicity assessment for the allele. Through automation and comprehensive documentation of evidence codes, the system facilitates more accurate application of the ACMG/AMP guidelines, improves standardization in variant classification, and facilitates collaborative resolution of discordances. The rules of reasoning are configurable with gene-specific or disease-specific guideline variations (e.g. cardiomyopathy-specific frequency thresholds and functional assays). The software is modular, equipped with robust application program interfaces (APIs), and available under a free open source license and as a cloud-hosted web service, thus facilitating both stand-alone use and integration with existing variant curation and interpretation systems. The Pathogenicity Calculator is accessible at http

Guide on Project Web Access of SFR R and D and Technology Monitoring System

International Nuclear Information System (INIS)

Lee, Dong Uk; Won, Byung Chool; Lee, Yong Bum; Kim, Young In; Hahn, Do Hee

2008-09-01

The SFR R and D and technology monitoring system based on the MS enterprise project management is developed for systematic effective management of 'Development of Basic Key Technologies for Gen IV SFR' project which was performed under the Mid- and Long-term Nuclear R and D Program sponsored by the Ministry of Education, Science and Technology. This system is a tool for project management based on web access. Therefore this manual is a detailed guide for Project Web Access(PWA). Section 1 describes the common guide for using of system functions such as project server 2007 client connection setting, additional outlook function setting etc. The section 2 describes the guide for system administrator. It is described the guide for project management in section 3, 4

Guide on Project Web Access of SFR R and D and Technology Monitoring System

Energy Technology Data Exchange (ETDEWEB)

Lee, Dong Uk; Won, Byung Chool; Lee, Yong Bum; Kim, Young In; Hahn, Do Hee

2008-09-15

The SFR R and D and technology monitoring system based on the MS enterprise project management is developed for systematic effective management of 'Development of Basic Key Technologies for Gen IV SFR' project which was performed under the Mid- and Long-term Nuclear R and D Program sponsored by the Ministry of Education, Science and Technology. This system is a tool for project management based on web access. Therefore this manual is a detailed guide for Project Web Access(PWA). Section 1 describes the common guide for using of system functions such as project server 2007 client connection setting, additional outlook function setting etc. The section 2 describes the guide for system administrator. It is described the guide for project management in section 3, 4.

A Novel Role of Human Holliday Junction Resolvase GEN1 in the Maintenance of Centrosome Integrity

DEFF Research Database (Denmark)

Gao, M.; Danielsen, Jannie Michaela Rendtlew; Wei, L.-Z.

2012-01-01

but not catalytic activity of GEN1 is required for preventing centrosome hyper-amplification, formation of multiple mitotic spindles, and multi-nucleation. Our findings provide novel insight into the biological functions of GEN1 by uncovering an important role of GEN1 in the regulation of centrosome integrity....

Université de Genève

CERN Multimedia

2008-01-01

Ecole de physique - Département de physique nucléaire et corspusculaire 24, quai Ernest-Ansermet 1211 GENÈVE 4 Tél: (022) 379 62 73 - Fax: (022) 379 69 92 Lundi 1er décembre 2008 PARTICLE PHYSICS SEMINAR at 17.00 hrs – Stückelberg Auditorium Superconducting Interfaces between Insulating Oxide Prof. Jean-Marc TRISCONE / Université de Genève At interfaces between complex oxides, electronic systems with unusual properties can be generated. A striking example is the interface between LaAlO3 and SrTiO3, two good insulating perovskite oxides, which was found in 2004 to be conducting with a high mobility. We recently discovered that the ground state of this system is a superconducting condensate, with a critical temperature of about 200 mK. The characteristics observed for the superconducting transitions are consistent with a two-dimensional superconducting sheet as thin as a few nanometers. Recent field effect experiments revealed the sensitivity of the normal and superconducting states to the carrier d...

Université de Genève

CERN Multimedia

2008-01-01

Ecole de physique - Département de physique nucléaire et corspusculaire 24, quai Ernest-Ansermet - 1211 GENÈVE 4 Tél: (022) 379 62 73 - Fax: (022) 379 69 92 Lundi 1er décembre 2008 PARTICLE PHYSICS SEMINAR at 17.00 hrs – Stückelberg Auditorium Superconducting Interfaces between Insulating Oxide Prof. Jean-Marc TRISCONE / Université de Genève At interfaces between complex oxides, electronic systems with unusual properties can be generated. A striking example is the interface between LaAlO3 and SrTiO3, two good insulating perovskite oxides, which was found in 2004 to be conducting with a high mobility. We recently discovered that the ground state of this system is a superconducting condensate, with a critical temperature of about 200 mK. The characteristics observed for the superconducting transitions are consistent with a two-dimensional superconducting sheet as thin as a few nanometers. Recent field effect experiments revealed the sensitivity of the normal and superconducting states to the carrier ...

IVS Organization

Science.gov (United States)

2004-01-01

International VLBI Service (IVS) is an international collaboration of organizations which operate or support Very Long Baseline Interferometry (VLBI) components. The goals are: To provide a service to support geodetic, geophysical and astrometric research and operational activities. To promote research and development activities in all aspects of the geodetic and astrometric VLBI technique. To interact with the community of users of VLBI products and to integrate VLBI into a global Earth observing system.

The GenABEL Project for statistical genomics.

Science.gov (United States)

Karssen, Lennart C; van Duijn, Cornelia M; Aulchenko, Yurii S

2016-01-01

Development of free/libre open source software is usually done by a community of people with an interest in the tool. For scientific software, however, this is less often the case. Most scientific software is written by only a few authors, often a student working on a thesis. Once the paper describing the tool has been published, the tool is no longer developed further and is left to its own device. Here we describe the broad, multidisciplinary community we formed around a set of tools for statistical genomics. The GenABEL project for statistical omics actively promotes open interdisciplinary development of statistical methodology and its implementation in efficient and user-friendly software under an open source licence. The software tools developed withing the project collectively make up the GenABEL suite, which currently consists of eleven tools. The open framework of the project actively encourages involvement of the community in all stages, from formulation of methodological ideas to application of software to specific data sets. A web forum is used to channel user questions and discussions, further promoting the use of the GenABEL suite. Developer discussions take place on a dedicated mailing list, and development is further supported by robust development practices including use of public version control, code review and continuous integration. Use of this open science model attracts contributions from users and developers outside the "core team", facilitating agile statistical omics methodology development and fast dissemination.

Genética, performance física humana e doping genético: o senso comum versus a realidade científica

Directory of Open Access Journals (Sweden)

Rodrigo Gonçalves Dias

2011-02-01

Full Text Available Atletas de elite são reconhecidos como fenômenos esportivos e o potencial para atingir níveis superiores de performance no esporte está parcialmente sob o controle de genes. A excelência atlética é essencialmente multifatorial e determinada por complexas interações entre fatores ambientais e genéticos. Existem aproximadamente 10 milhões de variantes genéticas dispersas por todo o genoma humano e uma parcela destas variantes têm demonstrado influenciar a responsividade ao treinamento físico. Os fenótipos de performance física humana parecem ser altamente poligênicos e alguns estudos têm comprovado a existência de raras combinações genotípicas em atletas. No entanto, os mecanismos pelos quais genes se interagem para amplificar a performance física são desconhecidos. O conhecimento sobre os genes que influenciam a treinabilidade somado ao potencial uso indevido dos avanços da terapia gênica, como a possível introdução de genes em células de atletas, fez surgir o termo doping genético, um novo e censurado método de amplificação da performance física, além dos limites fisiológicos. Aumentos na hipertrofia muscular esquelética e nos níveis de hematócrito estão sendo conseguidos através da manipulação da expressão de genes específicos, mas a grande parte das impressionáveis alterações foi obtida em experimentação com animais de laboratório. A compreensão dos resultados científicos envolvendo genética, performance física humana e doping genético é uma difícil tarefa. Com o propósito de evitar a contínua má interpretação e propagação de conceitos errôneos, esta revisão, intencionalmente, vem discutir as evidências científicas produzidas até o momento sobre o tema, permitindo a compreensão do atual "estado da arte"

Test Review: Advanced Clinical Solutions for WAIS-IV and WMS-IV

Science.gov (United States)

Chu, Yiting; Lai, Mark H. C.; Xu, Yining; Zhou, Yuanyuan

2012-01-01

The authors review the "Advanced Clinical Solutions for WAIS-IV and WMS-IV". The "Advanced Clinical Solutions (ACS) for the Wechsler Adult Intelligence Scale-Fourth Edition" (WAIS-IV; Wechsler, 2008) and the "Wechsler Memory Scale-Fourth Edition" (WMS-IV; Wechsler, 2009) was published by Pearson in 2009. It is a…

Genes and proteins of Escherichia coli (GenProtEc).

Science.gov (United States)

Riley, M; Space, D B

1996-01-01

GenProtEc is a database of Escherichia coli genes and their gene products, classified by type of function and physiological role and with citations to the literature for each. Also present are data on sequence similarities among E.coli proteins with PAM values, percent identity of amino acids, length of alignment and percent aligned. The database is available as a PKZip file by ftp from mbl.edu/pub/ecoli.exe. The program runs under MS-DOS on IMB-compatible machines. GenProtEc can also be accessed through the World Wide Web at URL http://mbl.edu/html/ecoli.html.

Reflexo da interação genótipo x ambiente sobre o melhoramento genético de feijão

OpenAIRE

Pereira, Thayse Cristine Vieira; Schmit, Rodolfo; Haveroth, Eduardo José; Melo, Rita Carolina de; Coimbra, Jefferson Luís Meirelles; Guidolin, Altamir Frederico; Backes, Rogério Luiz

2015-01-01

RESUMO: O objetivo foi avaliar os componentes da variância fenotípica e estimar a influência da interação genótipo*ambiente no rendimento de grãos em feijão. Os componentes da variância fenotípica foram estimados pelo método da máxima verossimilhança restrita e do melhor preditor linear não viesado (REML/BLUP), juntamente com o espaço de inferência específico. As avaliações foram realizadas nas safras agrícolas de 2006/07 a 2011/12 no município de Lages/SC. Durante o período, 104 genótipos fo...

ANALISIS SEKUEN GEN GLUTATION PEROKSIDASE (GPX1 SEBAGAI DETEKSI STRES OKSIDATIF AKIBAT INFEKSI MYCOBACTERIUM TUBERCULOSIS

Directory of Open Access Journals (Sweden)

Ari Yuniastuti

2013-02-01

Full Text Available Glutation merupakan antioksidan yang berperan dalam fungsi imun, dan diekspresikan secara genetik oleh urutan gen yang membentuk protein enzim Glutation Peroxidase (GPx1. Bila ekspresi gen berubah maka terjadi perubahan fungsi glutation dan kerentanan terhadap stress oksidatif. Metode yang digunakan adalah Kasus-kontrol. Sampel yang digunakan adalah sampel darah. Kelompok kasus adalah sampel darah pasien tuberkulosis paru sedangkan kelompok kontrol adalah sampel darah orang sehat. Pemeriksaan gen Glutation peroxidase (GPx1 menggunakan metode Polymerase Chain Reaction (PCR untuk melihat pita DNA pada pasien tuberkulosis par serta elektroforesis produk PCR-RFLP gen GPx1 kelompok sampel tuberkulosis. Hasil penelitian menunjukkan bahwa tidak terdapat hubungan yang bermakna antara polimorfisme gen GPx1 (p=0,365 pasein tuberkulois dengan individu sehat, sehingga tidak dapat digunakan sebagai alat deteksi kerentanan terhadap stress oksidatif pada pasien tuberkulosis. Perlu penelitian lanjutan yang menggunakan sampel lebih besar dan populasi etnik yang berbeda.

Industrial Waste Landfill IV upgrade package

International Nuclear Information System (INIS)

1994-01-01

The Y-12 Plant, K-25 Site, and ORNL are managed by DOE's Operating Contractor (OC), Martin Marietta Energy Systems, Inc. (Energy Systems) for DOE. Operation associated with the facilities by the Operating Contractor and subcontractors, DOE contractors and the DOE Federal Building result in the generation of industrial solid wastes as well as construction/demolition wastes. Due to the waste streams mentioned, the Y-12 Industrial Waste Landfill IV (IWLF-IV) was developed for the disposal of solid industrial waste in accordance to Rule 1200-1-7, Regulations Governing Solid Waste Processing and Disposal in Tennessee. This revised operating document is a part of a request for modification to the existing Y-12 IWLF-IV to comply with revised regulation (Rule Chapters 1200-1-7-.01 through 1200-1-7-.08) in order to provide future disposal space for the ORR, Subcontractors, and the DOE Federal Building. This revised operating manual also reflects approved modifications that have been made over the years since the original landfill permit approval. The drawings referred to in this manual are included in Drawings section of the package. IWLF-IV is a Tennessee Department of Environmental and Conservation/Division of Solid Waste Management (TDEC/DSWM) Class 11 disposal unit

IVS: Current Status and Future Plans

Science.gov (United States)

Behrend, D.; Nothnagel, A.; Petrachenko, W. T.; Tuccari, G.

2016-12-01

The International VLBI Service for Geodesy and Astrometry (IVS) is a globally operating service that coordinates and performs Very Long Baseline Interferometry (VLBI) activities through its constituent components. The VLBI activities are associated with the creation, provision, dissemination, and archiving of relevant VLBI data and products. The products mostly pertain to the determination of the celestial and terrestrial reference frames, the Earth orientation parameters (EOP), atmospheric parameters as well as other ancillary parameters. The IVS observational network currently consists of about 40 radio telescopes worldwide. Subsets of these telescopes (8-12 stations) participate in 24-hour observing sessions that are run several times per week and in 1-hour intensive sessions for UT1 determination every day. The current VLBI network was developed mainly in the 1970s and 1980s. A number of factors, including aging infrastructure and demanding new scientific requirements, started to challenge its future sustainability and relevance. In response, the IVS and other groups developed and started implementing the next generation VLBI system, called VGOS (VLBI Global Observing System), at existing and new sites. The VGOS network is expected to reach maturity in the early 2020s. We describe the current status, progress, and anticipated prospects of geodetic/astrometric VLBI and the IVS.

Polimorfismos del gen BoLA-DRB3.2* en ganado criollo colombiano

Directory of Open Access Journals (Sweden)

Darwin Hernández H.

2013-10-01

Full Text Available Objetivo. Caracterizar el polimorfismo del gen BoLA-DRB3.2* en las razas bovinas criollas y colombianas. Materiales y métodos. En 360 muestras de ADN de ocho razas bovinas criollas (Blanco Orejinegro, Casanareño, Costeño con Cuernos, Chino Santandereano, Caqueteño, Hartón del Valle, Romosinuano y San Martinero, dos razas sintéticas Colombianas (Lucerna y Velásquez y dos razas foráneas (Brahman y Holstein se evaluó el polimorfismo del gen BoLA-DRB3.2 mediante técnicas moleculares (PCR-RFLP; se calculó el número promedio de alelos (NPA, las frecuencias, la heterocigocidad esperada (He y observada (Ho, el equilibrio de Hardy-Weinberg, la estructura genética y los valores de FST y FIS. Resultados. El NPA fue 14.6 ± 3.8 siendo Caqueteño la raza con mayor NPA (25 y el menor el Chino Santandereano (10. Se encontraron 41 alelos BoLA-DRB3.2* los más frecuentes fueron *28, *37, *24, *23, *20, *27, *8, *16, *39 (0.17, 0.11, 0.10, 0.09, 0.09, 0.07, 0.07 y 0.06 respectivamente. Se encontró alta diversidad genética (He = 0.878 con mayor valor en Caqueteño (0.96 y menor en San Martinero (0.81. Todas las razas se encontraron en equilibrio de Hardy-Weinberg, se encontraron valores altamente significativos de diferenciación genética (FST= 0.044 y de coeficiente de endogamia (FIS = 0.249. Conclusiones. El ganado criollo colombiano posee alto polimorfismo del gen BoLA-DRB3.2* representado en los altos valores de NPA y diversidad génetica.

Direct complexonometric determination of thorium (IV), uranium (IV), neptunium (IV), plutonium (IV) by titration of diethylenetriaminepentaacetic acid with xylenol orange as indicator

International Nuclear Information System (INIS)

Rykov, A.G.; Piskunov, E.M.; Timofeev, G.A.

1975-01-01

The purpose of the present work was to develop a method of determining Th(IV), U(IV), Np(N) and Pu(IV) in acid solutions by titration with diethylenetriamine pentacetic acid, the indicator being xylenol orange. It has been established that Th, U, Np and Pu can be determined to within 0.5-1.5%. Th and U in quantities of tens of milligrams can be determined with greater accuracy, attaining hundredths of one per cent. During titration the determination is not hindered by singly- and doubly-charged metal ions, trivalent lanthanides and actinides, except plutonium. The proposed method can be used to determine U(IV) in the presence of considerable quantities of U(VI) and Np(IV) in the presence of Np(V). Total concentrations of uranium or neptunium are determined by reducing uranium (VI) or neptunium (V) by a standard method (for example, using metallic lead, cadmium or zinc amalgam) to the tetravalent state and applying the method described in the paper. (E.P.)

Variabilidade genética da produção anual da seringueira: estimativas de parâmetros genéticos e estudo de interação genótipo x ambiente Genetic variability of rubber tree annual yielding: estimates of genetic parameters and study of genotype x environment interaction

Directory of Open Access Journals (Sweden)

Paulo de Souza Gonçalves

1990-01-01

Full Text Available Selecionaram-se dezenove genótipos de seringueira (Hevea brasiliensis Muell. Arg. considerados como os melhores em vigor e produção em uma população de pés francos estabelecidos no campo de ensaios da Estação Experimental de Pindorama, com o objetivo de estudar a variabilidade genética e ambiental e a interação genótipo x ambiente sobre a produção durante cinco anos. Com base na análise da variância anual e conjunta, estimaram-se parâmetros genéticos para produção, na tentativa de quantificar o ganho genético com a seleção, e as correlações genéticas e fenotfpicas das produções ano a ano. Os resultados das análises da variância dentro de anos mostraram efeitos significativos para genótipos, sendo os efeitos da interação genótipo x ambiente altamente significativos. As estimativas de herdabilídade, no sentido amplo, ao nível de médias de parcelas, foram altas, com amplitude de 0,57 a 0,77, respectivamente, para o segundo e quinto ano de produção. As maiores percentagens de ganho genético foram obtidas no primeiro e quinto ano de produção, 39,03 e 27,57 respectivamente. Correlações genéticas e fenotípicas entre anos de sangria foram altas e significativas. Os altos valores de herdabilidade e ganho genético para o primeiro ano de sangria indicam que a seleção massal conduzida nesta fase proporciona, efetivamente, maior ganho na seleção.Nineteen rubber trees (Hevea brasiliensis Muell. Arg. considered as the best in growth and yield performance, were selected from a mature seedling population in the experimental field at the Pindorama Experiment Station of the "Instituto Agronômico de Campinas", São Paulo State, Brazil. Studies were carried out aiming to assess the annual environmental influence on genetic variation in five years of yielding. Components of variance were estimated from these analyses in an attempt to quantify genotype x environment interactions. The results of the analysis of

Investigating the reasons of variability in Si IV and C IV broad absorption line troughs of quasars

Science.gov (United States)

Stathopoulos, Dimitrios; Lyratzi, Evangelia; Danezis, Emmanuel; Antoniou, Antonios; Tzimeas, Dimitrios

2017-09-01

In this paper we analyze the C IV and Si IV broad absorption troughs of two BALQSOs (J101056.69+355833.3, J114548.38+393746.6) to the individual components they consist of. By analyzing a BAL trough to its components we have the advantage to study the variations of the individual absorbing systems in the line of sight and not just the variations of the whole absorption trough or the variations of selected portions of BAL troughs exhibiting changes. We find that the velocity shifts and FWHMs (Full Width at Half Maximum) of the individual components do not vary between an interval of six years. All variable components show changes in the optical depths at line centers which are manifested as variations in the EW (Equivalent Width) of the components. In both BALQSOs, over corresponding velocities, Si IV has higher incidence of variability than C IV. From our analysis, evidence is in favour of different covering fractions between C IV and Si IV. Finally, although most of our results favour the crossing cloud scenario as the cause of variability, there is also strong piece of evidence indicating changing ionization as the source of variability. Thus, a mixed situation where both physical mechanisms contribute to BAL variability is the most possible scenario.

Library generation and tests for the HAMMER system from the ENDF/B-IV data

International Nuclear Information System (INIS)

Queiroz Bogado Leite, S. de; Chalhoub, E.S.; Moraes, Marisa de.

1983-05-01

The modifications made to a number of programs belonging to the HAMMER system in order to process data from ENDF/B-IV are presented. An alternate scheme of representing the resonance region by means of extensive tabulation of profiles is made available for selected materials. Numerical examples illustrate comparisons of the results obtained with these libraries against those from the literature. (Author) [pt

APEnet+ 34 Gbps data transmission system and custom transmission logic

International Nuclear Information System (INIS)

Ammendola, R; Biagioni, A; Frezza, O; Lonardo, A; Cicero, F Lo; Paolucci, P S; Rossetti, D; Simula, F; Tosoratto, L; Vicini, P

2013-01-01

APEnet+ is a point-to-point, low-latency, 3D-torus network controller integrated in a PCIe Gen2 board based on the Altera Stratix IV FPGA. We characterize the transmission system (embedded transceivers driving external QSFP+ modules) analyzing signal integrity, throughput, latency, BER and jitter at different data rates up to 34 Gbps. We estimate the efficiency of a custom logic able to sustain 2.6 GB/s per link with an FPGA on-chip memory footprint of 40 KB, providing deadlock-free routing and systemic awareness of faults. Finally, we show the preliminary results obtained with the embedded transceivers of a next-generation FPGA and outline some ideas to increase the performance with the same FPGA memory footprint

APEnet+ 34 Gbps data transmission system and custom transmission logic

Energy Technology Data Exchange (ETDEWEB)

Ammendola, R [INFN Sezione di Roma Tor Vergata, Via della Ricerca Scientifica, 1 - 00133 Roma Italy (Italy); Biagioni, A; Frezza, O; Lonardo, A; Cicero, F Lo; Paolucci, P S; Rossetti, D; Simula, F; Tosoratto, L; Vicini, P [INFN Sezione di Roma, P.le Aldo Moro, 2 - 00185 Roma Italy (Italy)

2013-12-01

APEnet+ is a point-to-point, low-latency, 3D-torus network controller integrated in a PCIe Gen2 board based on the Altera Stratix IV FPGA. We characterize the transmission system (embedded transceivers driving external QSFP+ modules) analyzing signal integrity, throughput, latency, BER and jitter at different data rates up to 34 Gbps. We estimate the efficiency of a custom logic able to sustain 2.6 GB/s per link with an FPGA on-chip memory footprint of 40 KB, providing deadlock-free routing and systemic awareness of faults. Finally, we show the preliminary results obtained with the embedded transceivers of a next-generation FPGA and outline some ideas to increase the performance with the same FPGA memory footprint.

Explorations of new phases in the Ga(III)/In(III)-Mo(VI)-Se(IV)/Te(IV)-O systems.

Science.gov (United States)

Kong, Fang; Hu, Chun-Li; Hu, Ting; Zhou, Yong; Mao, Jiang-Gao

2009-07-07

Systematic explorations of new phases in the Ga(III)/In(III)-Mo(VI)-Se(IV)/Te(IV)-O systems by hydrothermal syntheses or solid-state reactions at high-temperature led to four new quaternary compounds, namely, Ga(2)MoQ(2)O(10) (Q = Se, Te), In(2)Mo(2)Se(2)O(13)(H(2)O) and In(2)MoTe(2)O(10). Ga(2)MoQ(2)O(10) (Q = Se, Te) are isostructural and their structures feature a 3D network of gallium selenite/tellurite with 12-member ring tunnels along b-axis, the distorted MoO(6) octahedra are attached on the wall of the above tunnels. The structure of In(2)Mo(2)Se(2)O(13)(H(2)O) features a new pillared-layered architecture composed of 2D indium(III) selenite layers that are interconnected by Mo(2)O(10) dimers, forming 8-membered ring tunnels along the b-axis. The structure of In(2)MoTe(2)O(10) features a 2D indium oxide layer formed by corner- and edge-sharing InO(6) and InO(7) polyhedra with MoO(4) tetrahedra and TeO(n) (n = 4, 5) polyhedra hanging on both sides of the layer, there are weak interlayer Te-O bonds of 2.512 A. Results of optical diffuse reflectance spectrum measurements indicate that all four compounds are insulators, which are in agreement with results of band structure calculations based on DFT methods.

Computational prediction of secretion systems and secretomes of Brucella: identification of novel type IV effectors and their interaction with the host.

Science.gov (United States)

Sankarasubramanian, Jagadesan; Vishnu, Udayakumar S; Dinakaran, Vasudevan; Sridhar, Jayavel; Gunasekaran, Paramasamy; Rajendhran, Jeyaprakash

2016-01-01

Brucella spp. are facultative intracellular pathogens that cause brucellosis in various mammals including humans. Brucella survive inside the host cells by forming vacuoles and subverting host defence systems. This study was aimed to predict the secretion systems and the secretomes of Brucella spp. from 39 complete genome sequences available in the databases. Furthermore, an attempt was made to identify the type IV secretion effectors and their interactions with host proteins. We predicted the secretion systems of Brucella by the KEGG pathway and SecReT4. Brucella secretomes and type IV effectors (T4SEs) were predicted through genome-wide screening using JVirGel and S4TE, respectively. Protein-protein interactions of Brucella T4SEs with their hosts were analyzed by HPIDB 2.0. Genes coding for Sec and Tat pathways of secretion and type I (T1SS), type IV (T4SS) and type V (T5SS) secretion systems were identified and they are conserved in all the species of Brucella. In addition to the well-known VirB operon coding for the type IV secretion system (T4SS), we have identified the presence of additional genes showing homology with T4SS of other organisms. On the whole, 10.26 to 14.94% of total proteomes were found to be either secreted (secretome) or membrane associated (membrane proteome). Approximately, 1.7 to 3.0% of total proteomes were identified as type IV secretion effectors (T4SEs). Prediction of protein-protein interactions showed 29 and 36 host-pathogen specific interactions between Bos taurus (cattle)-B. abortus and Ovis aries (sheep)-B. melitensis, respectively. Functional characterization of the predicted T4SEs and their interactions with their respective hosts may reveal the secrets of host specificity of Brucella.

Avaliação genética de touros usando produção em lactações completas ou parciais projetadas: 3. Confiabilidade e ganhos genéticos

Directory of Open Access Journals (Sweden)

Melo Cláudio Manoel Rodrigues de

2000-01-01

Full Text Available Para estudar a viabilidade de se usarem produções em lactações parciais, projetadas, na avaliação do mérito genético de touros, foram utilizadas 4595 lactações de 2254 vacas, filhas de 145 touros de 1618 matrizes, distribuídas em 18 rebanhos, com partos entre 1980 e 1997. A partir de 91, 151, 211 ou 241 dias de lactação, projetaram-se 10, 30, 50 ou 70% das lactações, para a duração da lactação observada e para 305 dias. As estimativas dos parâmetros genéticos foram obtidas pelo sistema MTDFREML. Incluíram-se no modelo, independente da característica, efeitos fixos de rebanho-ano, época de parto e idade da vaca ao parto, com termos linear e quadrático, considerando-se efeitos aleatórios de animal, efeito permanente de ambiente e erro. A média das confiabilidades, obtida por meio das produções estimadas (PE, variou de 0,60 a 0,67, utilizando-se P305 igual a 0,60. O ganho genético anual pela seleção dos touros utilizando as PE foi, em média, 24,27% maior que o ganho genético anual da P305, quando as lactações foram projetadas para a duração da lactação observada, e 25,65% superior, quando as lactações foram projetadas para P305. As confiabilidades obtidas, bem como os ganhos genéticos anuais estimados nas avaliações genéticas, usando as PE, foram semelhantes àquelas obtidas para a produção de leite até 305 dias.

Prevalencia de bacterias Gram negativas portadoras del gen blaKPC en hospitales de Colombia

Directory of Open Access Journals (Sweden)

Robinson Pacheco

2014-04-01

Full Text Available Introducción. Las enzimas carbapenemasas de tipo KPC tienen gran capacidad de diseminación, son causantes de epidemias y se asocian a mayor mortalidad y estancia hospitalaria. En Colombia se han venido reportando cada vez más desde 2007, pero se desconoce la prevalencia hospitalaria. Objetivo. Estimar la prevalencia hospitalaria del gen blaKPC. Materiales y métodos. Se evaluó la presencia del gen blaKPC y su ‘clonalidad’ en aislamientos de enterobacterias y Pseudomonas aeruginosa de pacientes hospitalizados. Resultados. De los 424 aislamientos evaluados durante el periodo de estudio, 273 cumplieron con criterios de elegibilidad, 31,1 % fue positivo para el gen blaKPC y, al ajustar por ‘clonalidad’, la positividad fue de 12,8 %. El gen blaKPC se encontró con mayor frecuencia en Klebsiella pneumoniae seguido de P. aeruginosa y otras enterobacterias. A pesar de que la unidad de cuidados intensivos aportó el mayor número de aislamientos, no se encontró un patrón más prevalente del gen blaKPC en las ellas que en las otras salas. El aparato respiratorio fue el sitio anatómico de origen con la mayor prevalencia. No se presentó estacionalidad en la frecuencia de los aislamientos portadores del gen blaKPC. Conclusión. Este estudio reveló la alta prevalencia del gen blaKPC en diferentes microorganismos aislados en varias instituciones hospitalarias del país. La extraordinaria capacidad de propagación del gen blaKPC, las dificultades del diagnóstico y la limitada disponibilidad de antibióticos plantean la apremiante necesidad de fortalecer los sistemas de vigilancia epidemiológica y ajustar oportunamente las políticas institucionales de uso racional de antibióticos con el fin de contener su diseminación a otras instituciones de salud del país.

Contribuciones de Sir Roland Fisher a la Estadística Genética

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Jaime Cuadros

2004-11-01

Full Text Available Sir Ronald Fisher (18901962 fue profesor de genética y muchas de sus innovaciones estadísticas encontraron expresión en el desarrollo de metodología en estadística genética. Sin embargo, mientras sus contribuciones en estadística matemática son fácilmente identificadas, en genética de poblaciones compartió su supremacía con Sewall Wright (1889 1988 y J. S. S. Haldane (1892 1965. Este documento muestra algunas de las mejores contribuciones de Fisher a las bases de la estadística genética, y sus interacciones con Wright y Haldane, los cuales contribuyeron al desarrollo del tema. Con la tecnología moderna, tanto la metodología la estadística como la información genética están cambiando. No obstante, muchos de los trabajos de Fisher permanecen relevantes, y pueden aun servir como una base para investigaciones futuras en el análisis estadístico de datos de DNA. El trabajo de este autor refleja su visión del papel de Ia estadística en Ia inferencia científica expresada en 1949

Emissivity of Candidate Materials for VHTR Applicationbs: Role of Oxidation and Surface Modification Treatments

International Nuclear Information System (INIS)

Sridharan, Kumar; Allen, Todd; Anderson, Mark; Cao, Guoping; Kulcinski, Gerald

2011-01-01

The Generation IV (GEN IV) Nuclear Energy Systems Initiative was instituted by the Department of Energy (DOE) with the goal of researching and developing technologies and materials necessary for various types of future reactors. These GEN IV reactors will employ advanced fuel cycles, passive safety systems, and other innovative systems, leading to significant differences between these future reactors and current water-cooled reactors. The leading candidate for the Next Generation Nuclear Plant (NGNP) to be built at Idaho National Lab (INL) in the United States is the Very High Temperature Reactor (VHTR). Due to the high operating temperatures of the VHTR, the Reactor Pressure Vessel (RPV) will partially rely on heat transfer by radiation for cooling. Heat expulsion by radiation will become all the more important during high temperature excursions during off-normal accident scenarios. Radiant power is dictated by emissivity, a material property. The NGNP Materials Research and Development Program Plan (1) has identified emissivity and the effects of high temperature oxide formation on emissivity as an area of research towards the development of the VHTR.

U(IV) fluorescence spectroscopy. A new speciation tool

Energy Technology Data Exchange (ETDEWEB)

Lehmann, Susanne; Brendler, Vinzenz [Helmholtz-Zentrum Dresden-Rossendorf e.V., Dresden (Germany). Surface Processes; Steudtner, Robin [Helmholtz-Zentrum Dresden-Rossendorf e.V., Dresden (Germany). Inst. of Resource Ecology

2017-06-01

We combined absorption and fluorescence spectroscopy to study the speciation of U(IV) in solution in concentrations down to 10{sup -6} M uranium. With our time-resolved laser-induced fluorescence setup we could determine the fluorescence decay time of U(IV) in perchloric as well as in chloric acid with 2.6 ± 0.3 ns at room temperature and 148.4 ± 6.5 ns at liquid nitrogen temperature. For the U(IV) sulfate system, we observed a bathochromic shift and a peak shape modification in the fluorescence spectra with increasing sulfate concentration in solution. Thus, the potential of U(IV) fluorescence for speciation analysis could be proven.

Caracterização e estimativa da variabilidade genética de genótipos de cebola Characterization and estimation of genetic variability of onion genotypes

Directory of Open Access Journals (Sweden)

Gerson Henrique Wamser

2012-06-01

Full Text Available Este trabalho teve como objetivo caracterizar genótipos de cebola cultivados em Santa Catarina e estimar a variabilidade genética existente entre os mesmos. Para isto foram avaliados quinze genótipos de cebola em dois ambientes, Ituporanga e Lages. O delineamento utilizado foi de blocos casualizados, com três repetições em cada ambiente. Foram avaliados o comprimento do pseudocaule; número de folhas por pseudocaule; diâmetro do pseudocaule; diâmetro do bulbo; altura do bulbo; peso do bulbo; relação altura:diâmetro do bulbo; produção total de bulbos; formato do bulbo; porcentagem de florescimento e porcentagem de bulbos podres. Os dados foram submetidos à análise de variância multivariada. Houve efeito significativo para a interação genótipos x ambientes, fato que causou diferenças nos valores de dissimilaridade em cada local. Foi elaborada uma matriz de dissimilaridade utilizando a distância de Mahalanobis. Os caracteres morfológicos e agronômicos utilizados foram suficientes para caracterizar os genótipos, indicando que os programas de melhoramento dispõem de uma ampla base genética para o desenvolvimento de novas cultivares.This study aimed to characterize onion genotypes grown in Santa Catarina state, Brazil and to estimate their genetic variability. Fifteen onion genotypes were evaluated in two locations, Ituporanga and Lages. The experimental design was of randomized blocks with three replications in each environment. We evaluated the length of the pseudostem, number of leaves per pseudostem, stem diameter, bulb diameter, height of the bulb, bulb weight, height:diameter ratio; total production of bulbs, bulb shape, flowering percentage and percentage of rotten bulbs. The data were subjected to multivariate analysis of variance. The results showed significant effects for genotype-environment interaction, fact that was reflected in the values of dissimilarity in each location. A matrix of dissimilarity was prepared

Internet Economics IV

Science.gov (United States)

2004-08-01

edts.): Internet Economics IV Technical Report No. 2004-04, August 2004 Information Systems Laboratory IIS, Departement of Computer Science University of...level agreements (SLA), Information technology (IT), Internet address, Internet service provider 16. PRICE CODE 17. SECURITY CLASSIFICATION 18... technology and its economic impacts in the Internet world today. The second talk addresses the area of AAA protocol, summarizing authentication

GeoBoost: accelerating research involving the geospatial metadata of virus GenBank records.

Science.gov (United States)

Tahsin, Tasnia; Weissenbacher, Davy; O'Connor, Karen; Magge, Arjun; Scotch, Matthew; Gonzalez-Hernandez, Graciela

2018-05-01

GeoBoost is a command-line software package developed to address sparse or incomplete metadata in GenBank sequence records that relate to the location of the infected host (LOIH) of viruses. Given a set of GenBank accession numbers corresponding to virus GenBank records, GeoBoost extracts, integrates and normalizes geographic information reflecting the LOIH of the viruses using integrated information from GenBank metadata and related full-text publications. In addition, to facilitate probabilistic geospatial modeling, GeoBoost assigns probability scores for each possible LOIH. Binaries and resources required for running GeoBoost are packed into a single zipped file and freely available for download at https://tinyurl.com/geoboost. A video tutorial is included to help users quickly and easily install and run the software. The software is implemented in Java 1.8, and supported on MS Windows and Linux platforms. gragon@upenn.edu. Supplementary data are available at Bioinformatics online.

The Contribution of IVS to IGGOS

Science.gov (United States)

Nothnagel, A.

2002-05-01

Since its inauguration in 1999, the International VLBI Service for Geodesy and Astrometry has made significant progress in the coordination and utilisation of worldwide VLBI resources. Improving the visibility of the IVS components to a wider public in turn led to a higher motivation of the individuals to contribute to the global effort. Not only the number of IVS components but also their investments in terms of funds and manpower demonstrate the increased awareness of the importance of this joint international endeavour. The different demands of the users but also of the contributors often require the definition of priorities which are only being acceptable due to the existence of a strong umbrella organisation like the IVS. Significant progress has also been made in the area of routine data analysis and combination of results. By now, six IVS Analysis Centers provide the redundancy necessary for a robust combination of the results. The use of ITRF2000 station coordinates as the basis for the IVS combined EOP series is the most recent step towards the generation of a consistent chain from the quasi-inertial frame of radio sources to system Earth.

Advanced Corrosion-Resistant Zr Alloys for High Burnup and Generation IV Application

International Nuclear Information System (INIS)

Jeong, Y. H.; Park, S. Y.; Lee, M. H.; Choi, B. K.; Baek, J. H.; Park, J. Y.; Kim, J. H.; Kim, H. G.; Jung, Y. H.; Bang, B. G.

2006-08-01

The systematic study was performed to develop the advanced corrosion-resistant Zr alloys for high burnup and Gen IV application. The corrosion behavior was significantly changed with the alloy composition and the corrosion environment. In general, the model alloys with a higher alloying elements showed a higher corrosion resistance. Among the model alloys tested in this study, Zr-10Cr-0.2Fe showed the best corrosion resistance regardless of the corrosion condition. The oxide on the higher corrosion-resistant alloy such as Zr-1.0Cr-0.2Fe consisted of mainly columnar grains, and it have a higher tetragonal phase stability. In comparison with other alloys being considered for the SCWR, the Zr alloys showed a lower corrosion rate than ferritic-martensitic steels. The results of this study imply that, at least from a corrosion standpoint, Zr alloys deserve consideration as potential cladding or structural materials in supercritical water cooled reactors

The Development of the Genital Psoriasis Sexual Frequency Questionnaire (GenPs-SFQ) to Assess the Impact of Genital Psoriasis on Sexual Health.

Science.gov (United States)

Gottlieb, Alice B; Kirby, Brian; Ryan, Caitriona; Naegeli, April N; Burge, Russel; Potts Bleakman, Alison; Anatchkova, Milena D; Cather, Jennifer

2018-03-01

Patient-reported outcome measures (PROs) exist for psoriasis but not genital psoriasis (GenPs). This cross-sectional, qualitative study in patients with moderate-to-severe GenPs was conducted to support development of a PRO for measuring the impact of GenPs on sexual activity and to establish content validity. The impacts of GenPs were identified in a literature review. Findings from the literature review were discussed with clinicians, and then patients with GenPs were interviewed. From the literature review, 52 articles, 44 abstracts, and 41 clinical trials met predefined search criteria. Of these, 11 concepts emerged as having theoretical support for use as measurable impacts of psoriasis symptoms on patients; these concepts included sexual functioning and general health-related quality of life (HRQoL). These concepts were confirmed and expanded upon by two clinicians who routinely care for patients with GenPs. Interviews were then conducted with GenPs patients (n = 20) to discuss the impact of GenPs on their HRQoL. Eighty percent of patients reported that GenPs impacted sexual frequency. The two-item GenPs Sexual Frequency Questionnaire (GenPs-SFQ) was developed to assess limitations on sexual activity frequency because of GenPs. Cognitive debriefing with an additional 50 patients with GenPs confirmed the utility and understandability of the GenPs-SFQ. The GenPs-SFQ may have utility in clinical trials involving GenPs patients and in routine clinical practice. Eli Lilly and Company. Plain language summary available for this article.

Discusión: Explicaciones genéticas y psicológicas de la esquizofrenia. Bases genéticas de la esquizofrenia: "Nurture vrs Nature

Directory of Open Access Journals (Sweden)

Henriette Raventós-Vorst

2003-01-01

Full Text Available El presente artículo revisa la evidencia científica que muestra la heredabilidad de la esquizofrenia, su forma de herencia compleja y la posible heterogeneidad genética y ambiental. Se presentan las regiones cromosómicas que han sido ligadas a la enfermedad y algunos de los genes candidatos. El objetivo es presentar los resultados más importantes en el campo de la investigación genética de la enfermedad. Aunque se acepta que factores ambientales deben estar presentes en la etiopatogenia de la enfermedad, no se profundiza en ellos. Finalmente, se comenta el modelo lamarquiano sugerido por el Prof.. Bolaños. El fin es transmitir que en la actualidad no hay contradicción entre el modelo biologista o psicológico que explicaban esta enfermedad. La concepción moderna une ambos modelos: se considera una enfermedad del neurodesarrollo en la que participan factores genéticos, factores epigenéticos y noxas ambientales, incluyendo los factores psicosociales.

Genes and proteins of Escherichia coli K-12 (GenProtEC).

Science.gov (United States)

Riley, M

1997-01-01

GenProtEC is a database of Escherichia coli genes and their gene products, classified by type of function and physiological role and with citations to the literature for each. Also present are data on sequence similarities amongE.coliproteins with PAM values, percent identity of amino acids, length of alignment and percent aligned. GenProtEC can also be accessed through the World Wide Web at URL http://mbl.edu/html/ecoli.html .

Variabilidad genética de la respuesta inflamatoria: I. Polimorfismo -511 C/T en el gen IL1β en diferentes subpoblaciones peruanas

Directory of Open Access Journals (Sweden)

Óscar Acosta

2012-07-01

Full Text Available El polimorfismo -511 citosina/timina (-511 C/T en la región promotora del gen interleuquina 1 beta (IL1β estα implicado en la producciσn diferencial de la citoquina y por tanto puede estar asociado a la respuesta inmuno-inflamatoria en obesidad, dislipidemias, cardiopatías, cáncer, infecciones, y el tratamiento con nutrientes y fármacos. Objetivos: Establecer la distribución de frecuencias de los genotipos y alelos del polimorfismo -511 C/T del gen IL1β en diferentes subpoblaciones peruanas. Diseño: Estudio descriptivo, observacional, transversal. Instituciones: Centro de Investigación de Bioquímica y Nutrición e Instituto de Medicina Tropical D.A. Carrión, Facultad de Medicina, UNMSM y Centro de Genética y Biología Molecular, Facultad de Medicina, USMP, Lima, Perú. Participantes: Pobladores peruanos. Intervenciones: Extracción de ADN genómico a partir de muestras sanguíneas o epitelio bucal según metodología estándar, de 168 individuos de 9 grupos subpoblacionales: 23 mestizos de Lima, 33 amazónicos (20 de Pucallpa y 13 de Amazonas y 112 andinos (12 de Ancash, 10 de Cajamarca, 18 de Huarochirí-Lima, 25 de Puno-Taquile, 25 de Puno-Uros y 22 de Puno-Anapia. Análisis del polimorfismo -511 C/T mediante la técnica de PCR/RFLP, con primers específicos y digestión con la enzima de restricción AvaI, detectándose los fragmentos por electroforesis en geles de agarosa al 2% y tinción con bromuro de etidio. Principales medidas de resultados: Frecuencias genotípicas y alélicas del gen IL1β. Resultados: Se encontró las siguientes frecuencias genotípicas CC=0,024; CT=0,369 y TT=0,607, consistentes con el equilibrio de Hardy-Weinberg; y las frecuencias alélicas fueron alelo C=0,208 y aleloT= 0,792. La frecuencia del alelo T, considerado el mutante, fue muy alta en los Uros de Puno (0.940 y más baja en los mestizos de Lima (0.609. La comparación de las frecuencias genotípicas (TT versus CT+CC y alélicas (T versus C

World Energy Data System (WENDS). Volume IV. Country data, SG-YO

Energy Technology Data Exchange (ETDEWEB)

None

1979-06-01

The World Energy Data System contains organized data on those countries and international organizations that may have critical impact on the world energy scene. Included in this volume, Vol. IV, are Senegal, South Africa, Soviet Union, Spain, Sweden, Switzerland, Taiwan, Tanzania, Thailand, Turkey, United Kingdom, United States, Upper Volta, Venezuela, and Yugoslavia. The following topics are covered for most of the countries: economic, demographic, and educational profiles; energy policy; indigenous energy resources and uses; forecasts, demand, exports, imports of energy supplies; environmental considerations of energy supplies; power production facilities; energy industries; commercial applications of energy; research and development activities of energy; and international activities.

Oxygen Atom Transfer Using an Iron(IV)-Oxo Embedded in a Tetracyclic N-Heterocyclic Carbene System: How Does the Reactivity Compare to Cytochrome P450 Compound I?

Science.gov (United States)

Cantú Reinhard, Fabián G; de Visser, Sam P

2017-02-24

N-Heterocyclic carbenes (NHC) are commonly featured as ligands in transition metal catalysis. Recently, a cyclic system containing four NHC groups with a central iron atom was synthesized and its iron(IV)-oxo species, [Fe IV (O)(cNHC 4 )] 2+ , was characterized. This tetracyclic NHC ligand system may give the iron(IV)-oxo species unique catalytic properties as compared to traditional non-heme and heme iron ligand systems. Therefore, we performed a computational study on the structure and reactivity of the [Fe IV (O)(cNHC 4 )] 2+ complex in substrate hydroxylation and epoxidation reactions. The reactivity patterns are compared with cytochrome P450 Compound I and non-heme iron(IV)-oxo models and it is shown that the [Fe IV (O)(cNHC 4 )] 2+ system is an effective oxidant with oxidative power analogous to P450 Compound I. Unfortunately, in polar solvents, a solvent molecule will bind to the sixth ligand position and decrease the catalytic activity of the oxidant. A molecular orbital and valence bond analysis provides insight into the origin of the reactivity differences and makes predictions of how to further exploit these systems in chemical catalysis. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

A study on a political trend about fuel cycle in U.S.A

Energy Technology Data Exchange (ETDEWEB)

Whang, Jooho; Shin, Sanghwa [Kyunghee Univ., Seoul (Korea, Republic of)

2008-05-15

Analyzing US policy-making mechanism and trends relating to GNEP (Global Nuclear Energy Partnership) and GEN-IV (Generation IV of Nuclear Energy System) - Need to prepare a comprehensive road map for negotiation of amendment to the current ROK-US Atomic Energy Agreement that provides for exercise of unilateral control. - Covering developments and trends relating to nuclear energy industry under discussion in Korea and elsewhere - Reviewing nuclear energy partnership arrangements between US and other countries and analyzing the contents of US-Japan nuclear energy agreement - Analyzing nuclear cycle policy trends relating to the US energy issues and spent fuel management. - Providing inputs for nuclear energy partnership between the US and ROK and negotiation of potential amendment to the ROK-US Atomic Energy Agreement in consideration of the US nuclear energy policy trends relating to GNEP and GEN-IV underway in the US.

Congenital bilateral neuroblastoma (stage IV-S): case report

International Nuclear Information System (INIS)

Lee, Jeong Hee; Lee, Hee Jung; Woo, Seong Ku; Lee, Sang Rak; Kim, Heung Sik

2002-01-01

Congenital neonatal neuroblastoma is not uncommon but bilateral adrenal neuroblastoma is rare, accounting for about ten percent of neuroblastomas in children. We report the US the MR findings of a stage IV-S congenital bilateral neuroblastoma occurring in a one-day-old neonate

Kinetics of a redox reaction in the system Ce(IV) β-diketonate - additional ligand

International Nuclear Information System (INIS)

Anufrieva, S.I.; Snezhko, N.I.; Pechurova, N.I.; Martynenko, L.N.; Spitsyn, V.I.

1982-01-01

Preparation of solutions containing stable compounds of Ce(IV) with organic ligands is difficult, because even strong Ce(IV) complexes undergo intramolecular reduction and have a tendency to hydrolysis. It is known that Ce(IV) β-diketonates have different resistances to reduction inorganic solvents, depending on the structure. Using spectrophotometric analysis we have investigated the oxidation-reduction characteristics of solutions of certain Ce(IV) β-diketonates in benzene in the absence and presence of neutral ligands containing donor O or N atoms

Epidemiologia genética: epidemiologia, genética ou nenhuma das anteriores?

Directory of Open Access Journals (Sweden)

Aguinaldo Gonçalves

1990-12-01

Full Text Available No esforço de contribuir para melhor entendimento da identidade da Epidemiologia Genética, são revistas sua concepção, campo de atuação, métodos e técnicas pertinentes e algumas instâncias de aplicação. Entendendo-a como a área de interesse dos fatores genéticos das doenças e suas interações ambientais, apresenta-se seu campo de atuação como constituído por dois segmentos: um descritivo, que lida com conhecimento da distribuição de tais afecções em famílias e populações, seu impacto a nível do coletivo e sua vigilância epidemiológica, bem como o estudo de seus determinantes; o segundo, caracterizado pela intervenção, refere-se às respectivas medidas preventivas. Em que pese possível limitação pela não-consideração de todas as situações existentes, particular atenção é destinada à revisão de métodos e técnicas que possam ser convergentemente aplicados, a partir de procedimentos genéticos e epidemiológicos. Entre eles, destacam-se como estudos de casos tanto metodologias laboratoriais (como os dermatóglifos quanto quantitativos, como cálculo de herdabilidade e análise multivariada. Alguns objetos de estudo são tomados como instância de aplicação, por contarem com investigações específicas em nosso meio: a hanseníase, o hidrargirismo e a esquizofrenia.In an attempt to contribute to a better undestanding of the identity of Genetic Epidemiology, we review its conception, its field of influence, its appropriate methods and techniques and, at last, some of its applications. Genetic Epidemiology involves the study of genetic factors acting on diseases and on their environmental interactions. These includes two major areas: a descriptive one, related to the distribution of such conditions in families and populations, to the epidemiologic surveillance and to the study of determinants; and another characterized by intervention, which is related to preventive measures. Because of the dificulty in

Variabilidad genética en Prosopis ferox (Mimosaceae

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Alicia D. Burghardt

2004-01-01

Full Text Available Prosopis ferox (Mimosaceae es una especie arbustiva o arbórea espinosa que se distribuye desde el Sur de Bolivia hasta el noroeste de la Argentina. En la provincia de Jujuy se encuentra a grandes alturas (entre los 2400 y los 3700 m s.m.. Existe una gran variabilidad morfológica, especialmente en cuanto a las dimensiones del fruto y la cantidad de semillas por fruto, ambas características importantes debido al uso de esta planta como forraje. Con el objeto de verificar si existe además variabilidad genética, se realizó un estudio electroforético de proteínas seminales de árboles procedentes de distintas localidades de la provincia de Jujuy. Los patrones polipeptídicos obtenidos por SDS-PAGE presentaron en total 26 bandas. Cada población se caracterizó por sus patrones de presencia-ausencia de bandas, habiéndose encontrado variabilidad intrapoblacional (polimorfismo en algunas de ellas, siendo otras genéticamente homogéneas. Los índices polimórficos en poblaciones de P. ferox son comparables a los obtenidos previamente en P. ruscifolia. La variabilidad genética interpoblacional hallada por medio del estudio electroforético de las proteínas seminales hace suponer la existencia de ecotipos

12 CFR Appendix IV to Part 27 - Home Loan Data Submission

Science.gov (United States)

2010-01-01

... 12 Banks and Banking 1 2010-01-01 2010-01-01 false Home Loan Data Submission IV Appendix IV to Part 27 Banks and Banking COMPTROLLER OF THE CURRENCY, DEPARTMENT OF THE TREASURY FAIR HOUSING HOME LOAN DATA SYSTEM Pt. 27, App. IV Appendix IV to Part 27—Home Loan Data Submission ER21JN94.003 ER21JN94...

Conceptual study of a complementary scram system for liquid metal cooled nuclear reactors

International Nuclear Information System (INIS)

Vanmaercke, S.; Van den Eynde, G.; Tijskens, E.; Bartosiewicz, Y.

2009-01-01

GEN-IV reactors promise higher safety and reliability as one of the major improvements over previous generations of reactors. To achieve that, all GEN-IV reactor concepts require two completely independent shutdown systems that rely on different operating principles. For liquid metal cooled reactors the first system is an absorber-rod based solution. The second system that by requirement should rely on another principle, is however quite a challenge to design. The second system used in current PWR reactors is to dissolve a neutron absorber, boric acid, into the primary coolant. This method cannot be used in liquid metal cooled reactors because of the high cost of cleaning the coolant. In this paper an overview of the existing literature on scram systems is given, each with their advantages and limitations. A promising new concept is also presented. This concept leads to a totally passive self activating device using small absorbing particles that flow into a dedicated channel to shutdown the reactor. The system consists of tubes filled with particles of an absorber material. During normal operation, these particles are kept above the active core by means of a metallic seal. In case of an accident, the system is activated by the temperature increase in the coolant. This leads to melting of the metal seal. The ongoing work conducted at SCK·CEN and UCL/TERM aims at assessing the reliability of this new concept both experimentally and numerically. This study is multidisciplinary as neutronic and thermal hydraulics issues are tackled. Most challenging is however the thermal hydraulics related to understanding and predicting the liberation and flow of the absorber particles during a shutdown. Simple experiments are envisaged to compare to numerical simulations using the Discrete Element Method for simulating the particles. In a later stage this will be coupled with Smoothed Particles Hydrodynamics for simulating the melting of the seal. Some preliminary experimental and

Construcción de un vector de expresión derivado de virus adenoasociados para corregir in vitro el defecto genético de la enfermedad de Morquio A

Directory of Open Access Journals (Sweden)

Luis Alejandro Barrera

2008-09-01

Full Text Available Introducción. La mucopolisacaridosis IV A (Morquio A es una enfermedad de depósito lisosómico causada por la deficiencia en la actividad de la enzima N-acetil-galactosamina- 6-sulfato-sulfatasa que produce la acumulación intralisosómica de queratán y condroitín-6-sulfato. Hasta el momento, su manejo es paliativo, por lo que las investigaciones se han enfocado en establecer una terapia que pueda aplicarse tempranamente y garantice la expresión estable de la enzima. En este sentido, la terapia génica se presenta como una de las potenciales alternativas terapéuticas para corregir el defecto genético en la mucopolisacaridosis IV A. Objetivo. Construir vectores de expresión derivados de virus adenoasociados para corregir in vitro la deficiencia enzimática en la mucopolisacaridosis IV A. Materiales y métodos. Se produjeron vectores derivados de virus adenoasociados que portaban el gen humano de la enzima N-acetil-galactosamina-6-sulfato-sulfatasa dirigido por el promotor temprano del citomegalovirus humano, empleando un sistema libre de adenovirus. Se transfectaron células HEK293 y fibroblastos humanos Morquio A con los virus recombinantes, y se determinó la actividad enzimática en el lisado celular a las 24 y 48 horas después de la transfección. Resultados. Se obtuvieron virus adenoasociados recombinantes, libres de adenovirus, con títulos hasta de 2,08 x 1010 cápsides/ml. Tanto en células HEK293 como en fibroblastos Morquio A transfectados, se obtuvieron actividades enzimáticas hasta de 3,05 nmoles/mg por hora, 48 horas después de la transfección. Conclusión. Los virus recombinantes producidos expresaron in vitro la enzima GALNS en las células transfectadas. Estos resultados constituyen el paso inicial para el desarrollo de una terapia génica para la enfermedad de Morquio A empleando vectores derivados de virus adenoasociados.

GenRGenS: Software for Generating Random Genomic Sequences and Structures

OpenAIRE

Ponty , Yann; Termier , Michel; Denise , Alain

2006-01-01

International audience; GenRGenS is a software tool dedicated to randomly generating genomic sequences and structures. It handles several classes of models useful for sequence analysis, such as Markov chains, hidden Markov models, weighted context-free grammars, regular expressions and PROSITE expressions. GenRGenS is the only program that can handle weighted context-free grammars, thus allowing the user to model and to generate structured objects (such as RNA secondary structures) of any giv...

Permanence of a predator-prey discrete system with Holling-IV functional response and distributed delays.

Science.gov (United States)

Zhang, X; Wu, Z; Zhou, T

2016-01-01

A predator-prey discrete-time model with Holling-IV functional response and distributed delays is investigated in this paper. By using the comparison theorem of the difference equation and some analysis technique, some sufficient conditions are obtained for the permanence of the discrete predator-prey system. Two examples are given to illustrate the feasibility of the obtained result.

Frecuencia de algunas enfermedades genéticas en Neuropediatría

Directory of Open Access Journals (Sweden)

Tatiana Zaldívar Vaillant

2012-12-01

Full Text Available Introducción: las enfermedades neurológicas en Pediatría son diversas y obedecen a un gran número de causas: infecciosas, genéticas, metabólicas y degenerativas, entre otras. El diagnóstico genético, dentro del método clínico en Neurología, está relacionado con el diagnóstico etiológico. Existen muy pocas publicaciones que reflejen la frecuencia de las enfermedades neurogenéticas como grupo etiológico. Objetivo: describir la frecuencia de algunas enfermedades neuropediátricas en la Consulta de Neurogenética del Instituto de Neurología y Neurocirugía. Métodos: se realizó una investigación descriptiva y prospectiva en el periodo 2008-2010. Se clasificó a los pacientes por grupos etarios, y se calculó el porcentaje de frecuencia para la atrofia muscular espinal de la infancia, la distrofia muscular tipo Duchenne/Becker, las lesiones estáticas del sistema nervioso central de causa prenatal genética, y para la clasificación de los grupos según tipo de herencia. Resultados: el universo de estudio estuvo conformado por 161 pacientes, 72,6 % del sexo masculino, para una razón de la variable sexo de 2,5. Los escolares fueron mayoría (37,8 %, y la edad promedio 5 años. La distrofia muscular tipo Duchenne fue la enfermedad más frecuente (24,8 %. El 41,40 % clasificó en la herencia autosómica recesiva. Los resultados coinciden con lo reportado en la literatura. Conclusiones: las enfermedades neuromusculares hereditarias, y las lesiones estáticas del sistema nervioso central de causa prenatal genética, son las más frecuentes de solicitud de asesoramiento genético en un servicio de Neurogenética.

Tantalum-Addition Effect on Tensile and Creep Properties in 9Cr-0.5Mo-2W-V-Nb Steels

International Nuclear Information System (INIS)

Kim, Woo Gon; Kim, Sung Ho; Back, Jong Hyuk; Kim, Tae Kyu; Lee, Chan Bock

2011-01-01

Ferritic/martensitic steels (FMS) are being considered prospectively as cladding materials of a SFR fuel in Gen-IV nuclear systems. There are sound technical justifications for these material selections, and the adoption of the FM steels for a wide range of nuclear and non-nuclear applications has generated much industrial technology and experience. However, there are strong incentives to develop advanced materials, especially cladding, for a Gen-IV SFR. To develop an improved FM steel for the Gen-IV SFR fuel cladding in Korea, a R and D program has been progressed since 2007. Categories of materials considered in the program included 8∼12% Cr FM steels. A strong recommendation was made for the development of a high strength steel equivalent to or superior to ASTM Gr.92 steel (hereafter Gr. 92) to offset the difficulties encountered with commercial available high Cr (8∼12%) steels. Since the fuel cladding in a Gen-IV SFR would operate under higher temperatures than 600 .deg. C, contacting with liquid sodium, and be irradiated by neutrons to as high as 200dpa, the developed cladding should thus sustain both superior irradiation and temperature stabilities during its operational life. The newly developed advanced steel should also overcome severe drawbacks: mechanical properties, especially creep, are deteriorated at a higher temperature over 600 .deg. C. The aim of this study is to investigate the effect of Ta addition on the tensile and creep properties of the three alloys which are designed, manufactured and tested. Their properties are obtained and compared for developing new FM fuel cladding materials

Hold your horSSEs: controlling structure-selective endonucleases MUS81 and Yen1/GEN1.

Science.gov (United States)

Blanco, Miguel G; Matos, Joao

2015-01-01

Repair of DNA lesions through homologous recombination promotes the establishment of stable chromosomal interactions. Multiple helicases, topoisomerases and structure-selective endonucleases (SSEs) act upon recombining joint molecules (JMs) to disengage chromosomal connections and safeguard chromosome segregation. Recent studies on two conserved SSEs - MUS81 and Yen1/GEN1- uncovered multiple layers of regulation that operate to carefully tailor JM-processing according to specific cellular needs. Temporal restriction of SSE function imposes a hierarchy in pathway usage that ensures efficient JM-processing while minimizing reciprocal exchanges between the recombining DNAs. Whereas a conserved strategy of fine-tuning SSE functions exists in different model systems, the precise molecular mechanisms to implement it appear to be significantly different. Here, we summarize the current knowledge on the cellular switches that are in place to control MUS81 and Yen1/GEN1 functions.

Diffuse reticuloendothelial system involvement in type IV glycogen storage disease with a novel GBE1 mutation: a case report and review.

Science.gov (United States)

Magoulas, Pilar L; El-Hattab, Ayman W; Roy, Angshumoy; Bali, Deeksha S; Finegold, Milton J; Craigen, William J

2012-06-01

Glycogen storage disease type IV is a rare autosomal recessive disorder of glycogen metabolism caused by mutations in the GBE1 gene that encodes the 1,4-alpha-glucan-branching enzyme 1. Its clinical presentation is variable, with the most common form presenting in early childhood with primary hepatic involvement. Histologic manifestations in glycogen storage disease type IV typically consist of intracytoplasmic non-membrane-bound inclusions containing abnormally branched glycogen (polyglucosan bodies) within hepatocytes and myocytes. We report a female infant with classic hepatic form of glycogen storage disease type IV who demonstrated diffuse reticuloendothelial system involvement with the spleen, bone marrow, and lymph nodes infiltrated by foamy histiocytes with intracytoplasmic polyglucosan deposits. Sequence analysis of the GBE1 gene revealed compound heterozygosity for a previously described frameshift mutation (c.1239delT) and a novel missense mutation (c.1279G>A) that is predicted to alter a conserved glycine residue. GBE enzyme analysis revealed no detectable activity. A review of the literature for glycogen storage disease type IV patients with characterized molecular defects and deficient enzyme activity reveals most GBE1 mutations to be missense mutations clustering in the catalytic enzyme domain. Individuals with the classic hepatic form of glycogen storage disease type IV tend to be compound heterozygotes for null and missense mutations. Although the extensive reticuloendothelial system involvement that was observed in our patient is not typical of glycogen storage disease type IV, it may be associated with severe enzymatic deficiency and a poor outcome. Copyright © 2012 Elsevier Inc. All rights reserved.

Development of Preliminary PIRTs of Thermal-Hydraulic Phenomena for KALIMER-600

International Nuclear Information System (INIS)

Kwon, Young Min; Jeong, Hae Yong; Ha, Kwi Seok; Chang, Won Pyo

2009-01-01

Sodium Cooled Fast Reactors (SFRs) are the most technologically developed of the GEN IV systems. The primary mission of the SFRs is the management of high-level wastes, in particular management of plutonium and other actinides. The SFR system is the nearest-term actinide management system among the GEN-IV system candidates. The mission of the SFR can be extended to electricity production if design innovations that reduce capital cost. KAERI has been performing design studies of KALIMER-600 at the conceptual level. To bring KALIMER-600 to deployment, several technology gaps in fuel cycle and reactor system must be closed. Research on both sides of the fuel cycle and the reactor system is necessary to bring KALIMER-600 to deployment. For the reactor system, technology gaps exist in assurance or verification of passive safety, and completion of the metallic fuel database including irradiation performance data. R and D programs for the KALIMER-600 safety are necessary to support the SFR deployment. The safety R and D challenges for the KALIMER-600 in the context of the GEN IV systems are: (a) to verify the predictability and effectiveness of the inherent passive benign responses to design basis events and accommodated beyond design basis events (b) to provide assurance that accommodated beyond design basis events considered in licensing can be sustained without loss of coolability of fuel and structural integrity. The Phenomena Identification and Ranking Table (PIRT) is an effective tool for providing an expert assessment of safety-related phenomena and for assessing R and D needs for KALIMER-600 licensing. The nine-step PIRT process has been established as a methodology for providing expert assessments of safety-relevant phenomena

Nuclear Fuel Cycle System Analysis (II)

Energy Technology Data Exchange (ETDEWEB)

Ko, Won Il; Kwon, Eun Ha; Yoon, Ji Sup; Park, Seong Won

2007-04-15

As a nation develops strategies that provide nuclear energy while meeting its various objectives, it must begin with identification of a fuel cycle option that can be best suitable for the country. For such a purpose, this paper takes four different fuel cycle options that are likely adopted by the Korean government, considering the current status of nuclear power generation and the 2nd Comprehensive Nuclear Energy Promotion Plan (CNEPP) - Once-through Cycle, DUPIC Recycle, Thermal Reactor Recycle and GEN-IV Recycle. The paper then evaluates each option in terms of sustainability, environment-friendliness, proliferation-resistance, economics and technologies. Like all the policy decision, however, a nuclear fuel cycle option can not be superior in all aspects of sustainability, environment-friendliness, proliferation-resistance, economics, technologies and so on, which makes the comparison of the options extremely complicated. Taking this into consideration, the paper analyzes all the four fuel cycle options using the Multi-Attribute Utility Theory (MAUT) and the Analytic Hierarchy Process (AHP), methods of Multi-Attribute Decision Making (MADM), that support systematical evaluation of the cases with multi- goals or criteria and that such goals are incompatible with each other. The analysis shows that the GEN-IV Recycle appears to be most competitive.

Irradiation Alters MMP-2/TIMP-2 System and Collagen Type IV Degradation in Brain

Energy Technology Data Exchange (ETDEWEB)

Lee, Won Hee [School of Biomedical Engineering and Sciences, Virginia Polytechnic Institute and State University, Blacksburg, Virginia (United States); Warrington, Junie P.; Sonntag, William E. [Reynolds Oklahoma Center on Aging, Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma (United States); Lee, Yong Woo, E-mail: ywlee@vt.edu [School of Biomedical Engineering and Sciences, Virginia Polytechnic Institute and State University, Blacksburg, Virginia (United States); Department of Biomedical Sciences and Pathobiology, Virginia Polytechnic Institute and State University, Blacksburg, Virginia (United States)

2012-04-01

Purpose: Blood-brain barrier (BBB) disruption is one of the major consequences of radiation-induced normal tissue injury in the central nervous system. We examined the effects of whole-brain irradiation on matrix metalloproteinases (MMPs)/tissue inhibitors of metalloproteinases (TIMPs) and extracellular matrix (ECM) degradation in the brain. Methods and Materials: Animals received either whole-brain irradiation (a single dose of 10 Gy {gamma}-rays or a fractionated dose of 40 Gy {gamma}-rays, total) or sham-irradiation and were maintained for 4, 8, and 24 h following irradiation. mRNA expression levels of MMPs and TIMPs in the brain were analyzed by real-time reverse transcriptase-polymerase chain reaction (PCR). The functional activity of MMPs was measured by in situ zymography, and degradation of ECM was visualized by collagen type IV immunofluorescent staining. Results: A significant increase in mRNA expression levels of MMP-2, MMP-9, and TIMP-1 was observed in irradiated brains compared to that in sham-irradiated controls. In situ zymography revealed a strong gelatinolytic activity in the brain 24 h postirradiation, and the enhanced gelatinolytic activity mediated by irradiation was significantly attenuated in the presence of anti-MMP-2 antibody. A significant reduction in collagen type IV immunoreactivity was also detected in the brain at 24 h after irradiation. In contrast, the levels of collagen type IV were not significantly changed at 4 and 8 h after irradiation compared with the sham-irradiated controls. Conclusions: The present study demonstrates for the first time that radiation induces an imbalance between MMP-2 and TIMP-2 levels and suggests that degradation of collagen type IV, a major ECM component of BBB basement membrane, may have a role in the pathogenesis of brain injury.

Irradiation Alters MMP-2/TIMP-2 System and Collagen Type IV Degradation in Brain

International Nuclear Information System (INIS)

Lee, Won Hee; Warrington, Junie P.; Sonntag, William E.; Lee, Yong Woo

2012-01-01

Purpose: Blood-brain barrier (BBB) disruption is one of the major consequences of radiation-induced normal tissue injury in the central nervous system. We examined the effects of whole-brain irradiation on matrix metalloproteinases (MMPs)/tissue inhibitors of metalloproteinases (TIMPs) and extracellular matrix (ECM) degradation in the brain. Methods and Materials: Animals received either whole-brain irradiation (a single dose of 10 Gy γ-rays or a fractionated dose of 40 Gy γ-rays, total) or sham-irradiation and were maintained for 4, 8, and 24 h following irradiation. mRNA expression levels of MMPs and TIMPs in the brain were analyzed by real-time reverse transcriptase-polymerase chain reaction (PCR). The functional activity of MMPs was measured by in situ zymography, and degradation of ECM was visualized by collagen type IV immunofluorescent staining. Results: A significant increase in mRNA expression levels of MMP-2, MMP-9, and TIMP-1 was observed in irradiated brains compared to that in sham-irradiated controls. In situ zymography revealed a strong gelatinolytic activity in the brain 24 h postirradiation, and the enhanced gelatinolytic activity mediated by irradiation was significantly attenuated in the presence of anti-MMP-2 antibody. A significant reduction in collagen type IV immunoreactivity was also detected in the brain at 24 h after irradiation. In contrast, the levels of collagen type IV were not significantly changed at 4 and 8 h after irradiation compared with the sham-irradiated controls. Conclusions: The present study demonstrates for the first time that radiation induces an imbalance between MMP-2 and TIMP-2 levels and suggests that degradation of collagen type IV, a major ECM component of BBB basement membrane, may have a role in the pathogenesis of brain injury.

The G4-ECONS Economic Evaluation Tool for Generation IV Reactor Systems and its Proposed Application to Deliberately Small Reactor Systems and Proposed New Nuclear Fuel Cycle Facilities. Annex IX

Energy Technology Data Exchange (ETDEWEB)

NONE

2013-12-15

At the outset of the international Generation IV programme, it was decided that the six candidate reactor systems will ultimately be evaluated on the basis of safety, sustainability, non-proliferation attributes, technical readiness and projected economics. It is likely that the same factors will influence the evaluation of deliberately small reactor systems1 and new fuel cycle facilities, such as reprocessing plants that are being considered under the more recent Global Nuclear Energy Partnership (GNEP). This annex describes how the development of an economic modelling system has evolved to address the issue of economic competitiveness for both the Generation IV and GNEP programmes. In 2004, the Generation IV Economic Modelling Working Group (EMWG) commissioned the development of a Microsoft Excel based model capable of calculating the levelized unit electricity cost (LUEC) in mills/kW.h (1 mill = $10{sup -3}) or $/MW.h for multiple types of reactor system being developed under the Generation IV programme. This overall modelling system is now called the Generation IV spreadsheet calculation of nuclear systems (G4-ECONS), and is being expanded to calculate costs of energy products in addition to electricity, such as hydrogen and desalinated water. A version has also been developed to evaluate the costs of products or services from fuel cycle facilities. The cost estimating methodology and algorithms are explained in detail in the Generation IV Cost Estimating Guidelines and in the G4-ECONS User's Manual. The model was constructed with relatively simple economic algorithms such that it could be used by almost any nation without regard to country specific taxation, cost accounting, depreciation or capital cost recovery methodologies. It was also designed with transparency to the user in mind (i.e. all algorithms and cell contents are visible to the user). A short description of version 1.0 G4-ECONS-R (reactor economics model) has also been published in the

The G4-ECONS Economic Evaluation Tool for Generation IV Reactor Systems and its Proposed Application to Deliberately Small Reactor Systems and Proposed New Nuclear Fuel Cycle Facilities. Annex IX

International Nuclear Information System (INIS)

2013-01-01

At the outset of the international Generation IV programme, it was decided that the six candidate reactor systems will ultimately be evaluated on the basis of safety, sustainability, non-proliferation attributes, technical readiness and projected economics. It is likely that the same factors will influence the evaluation of deliberately small reactor systems1 and new fuel cycle facilities, such as reprocessing plants that are being considered under the more recent Global Nuclear Energy Partnership (GNEP). This annex describes how the development of an economic modelling system has evolved to address the issue of economic competitiveness for both the Generation IV and GNEP programmes. In 2004, the Generation IV Economic Modelling Working Group (EMWG) commissioned the development of a Microsoft Excel based model capable of calculating the levelized unit electricity cost (LUEC) in mills/kW.h (1 mill = $10 -3 ) or $/MW.h for multiple types of reactor system being developed under the Generation IV programme. This overall modelling system is now called the Generation IV spreadsheet calculation of nuclear systems (G4-ECONS), and is being expanded to calculate costs of energy products in addition to electricity, such as hydrogen and desalinated water. A version has also been developed to evaluate the costs of products or services from fuel cycle facilities. The cost estimating methodology and algorithms are explained in detail in the Generation IV Cost Estimating Guidelines and in the G4-ECONS User's Manual. The model was constructed with relatively simple economic algorithms such that it could be used by almost any nation without regard to country specific taxation, cost accounting, depreciation or capital cost recovery methodologies. It was also designed with transparency to the user in mind (i.e. all algorithms and cell contents are visible to the user). A short description of version 1.0 G4-ECONS-R (reactor economics model) has also been published in the Proceedings of

Ganho de seleção no melhoramento genético intrapopulacional do maracujazeiro-amarelo

Directory of Open Access Journals (Sweden)

Willian Krause

2012-01-01

Full Text Available O objetivo deste trabalho foi estimar o ganho de seleção associado a características agronômicas de importância no melhoramento intrapopulacional do maracujazeiro-amarelo. O experimento foi realizado em campo, no Município de Terra Nova do Norte, MT, com a avaliação de 111 famílias de irmãos completos (FIC e seis cultivares comerciais, utilizadas como testemunhas. Utilizou-se o delineamento de blocos ao acaso, com três repetições e quatro plantas por parcela. Foram avaliadas as seguintes características: produtividade, comprimento, diâmetro e peso médio dos frutos, percentagem e peso de polpa, espessura de casca e teor de sólidos solúveis. Para verificar a existência de variabilidade genética entre os genótipos, estimaram-se os parâmetros genéticos da população com base na média das famílias. Os 30 genótipos com o menor valor da soma de postos, de acordo com o índice de seleção de Mulamba & Mock, foram selecionados para estimar os ganhos genéticos. Observaram-se altos valores médios para as características e parâmetros genéticos avaliados nas 26 FIC e nas quatro testemunhas selecionadas. O uso do índice de seleção proporciona ganhos genéticos positivos em produtividade, percentagem e peso de polpa, comprimento, diâmetro e peso de frutos, e espessura de casca.

Coeficiente de repetibilidade e parâmetros genéticos em capim-elefante

Directory of Open Access Journals (Sweden)

Marcelo Cavalcante

2012-04-01

Full Text Available O objetivo deste trabalho foi determinar os coeficientes de repetibilidade de caracteres morfofisiológicos em genótipos de capim-elefante (Pennisetum spp., a partir de dados obtidos durante seis ciclos de avaliação. Foram estimados: número mínimo de medições e parâmetros genéticos. Utilizou-se o delineamento experimental de blocos ao acaso, em arranjo de parcelas subdivididas, com quatro níveis de N (controle, 30, 60 e 90 kg ha‑1 por corte e 16 genótipos de Pennisetum (11 híbridos interespecíficos e cinco cultivares. Os ciclos consistiram de avaliações em 2010 (21/4, 19/7 e 28/9 e 2011 (6/1, 7/4 e 3/8. Os coeficientes de repetibilidade foram de média‑alta magnitude para todas as variáveis, o que indica que houve regularidade entre as medidas repetidas. Para as variáveis massa de forragem, altura da planta, comprimento e largura da folha, diâmetro do colmo, clorose e índice de área foliar, três ciclos de avaliação são suficientes para obter R² de 90%, pela análise de componentes principais. Para o comprimento do entrenó, o mínimo de sete avaliações é necessário para predizer o valor real dos genótipos. Os parâmetros genéticos das variáveis massa de forragem, comprimento e largura da folha, diâmetro do colmo e clorose foliar são de alta magnitude, o que favorece a seleção de genótipos superiores de Pennisetum.

Divergência entre genótipos de soja, cultivados em várzea irrigada

Directory of Open Access Journals (Sweden)

Elonha Rodrigues dos Santos

2011-12-01

Full Text Available A divergência genética é um dos mais importantes parâmetros avaliados por melhoristas de plantas, na fase inicial de um programa de melhoramento genético. Diante disso, objetivou-se com este trabalho avaliar, por meio de técnicas multivariadas, a divergência genética entre 48 genótipos de soja, cultivados em várzea irrigada no Estado do Tocantins, com o intuito de identificar as combinações mais promissoras para produzir recombinações superiores, tanto destinados a produção de óleo e farelo, como do grupo especial, destinados ao consumo humano. O experimento foi conduzido no município de Formoso do Araguaia, TO, em cultivo de várzea irrigada na entressafra de 2010. O delineamento experimental foi o de blocos ao acaso, com quatro repetições. Verificou-se variabilidade entre os genótipos testados. Os resultados dos métodos de agrupamento de Tocher, UPGMA e Variáveis Canônicas foram concordantes entre si e detectaram quatro grupos distintos. As seguintes hibridações são promissoras para produção de grãos de soja destinados a óleo e farelo: M-Soy 8766, M-Soy 9144, A 7002 e M-Soy 9056 com Amaralina e cruzamentos entre M-Soy 8766, M-Soy 9144 e Amaralina com BRSMG 790A, BRS 257, BRS 216 e BRS 213 e são indicados visando a genótipos de soja especiais para alimentação humana.

Two-stage precipitation of neptunium (IV) oxalate

International Nuclear Information System (INIS)

Luerkens, D.W.

1983-07-01

Neptunium (IV) oxalate was precipitated using a two-stage precipitation system. A series of precipitation experiments was used to identify the significant process variables affecting precipitate characteristics. Process variables tested were input concentrations, solubility conditions in the first stage precipitator, precipitation temperatures, and residence time in the first stage precipitator. A procedure has been demonstrated that produces neptunium (IV) oxalate particles that filter well and readily calcine to the oxide

Caracteres clínico-patológicos y perfil genético en el carcinoma colorrectal

Directory of Open Access Journals (Sweden)

Florencia Perazzo

2013-10-01

Full Text Available El cáncer colorrectal es el tercer cáncer más frecuente en hombres y el segundo más frecuente en mujeres, con una incidencia mundial aproximada de 1.2 millones de casos nuevos por año. Nuestro objetivo primario fue estudiar la relación existente entre las características clínico-histológicas en individuos con cáncer colorrectal y el estado mutacional de los codones 12 y 13 del gen KRAS (7 mutaciones validadas, con el fin de hallar un marcador histopatológico para los tumores mutados. El objetivo secundario fue determinar cuántos pacientes tenían mutaciones adicionales en los codones 15 y 61 del gen KRAS y 600 del gen BRAF que podrían modificar el fenotipo tumoral. Fueron seleccionados 60 individuos con cáncer colorrectal (30 wild-type y 30 con mutaciones validadas en los codones 12 y 13 del gen KRAS. Se amplificaron y secuenciaron del gen KRAS los exones 2 y 3, y del gen BRAF el exón 15. La información recolectada se examinó mediante un análisis descriptivo, análisis univariado y/o análisis multivariado, según correspondiese. En conclusión, no se encontró relación entre las características clínico-histológicas de los tumores de individuos con diagnóstico de cáncer colorrectal y el estado mutacional de los codones 12 y 13 del gen KRAS. No hallamos un marcador histopatológico para los tumores mutados. En pacientes con adenocarcinomas colorrectales avanzados y KRAS wild-type resulta de interés considerar el estudio del codón 600 del gen BRAF.

Real Time Corrosion Monitoring in Lead and Lead-Bismuth Systems

Energy Technology Data Exchange (ETDEWEB)

James F. Stubbins; Alan Bolind; Ziang Chen

2010-02-25

The objective of this research program is to develop a real-time, in situ corrosion monitoring technique for flowing liquid Pb and eutectic PbBi (LBE) systems in a temperature range of 400 to 650 C. These conditions are relevant to future liquid metal cooled fast reactor operating parameters. THis program was aligned with the Gen IV Reactor initiative to develp technologies to support the design and opertion of a Pb or LBE-cooled fast reactor. The ability to monitor corrosion for protection of structural components is a high priority issue for the safe and prolonged operation of advanced liquid metal fast reactor systems. In those systems, protective oxide layers are intentionally formed and maintained to limit corrosion rates during operation. This program developed a real time, in situ corrosion monitoring tecnique using impedance spectroscopy (IS) technology.

Alimentos Transgénicos : Organismos Genéticamente Modificados (OGM)

OpenAIRE

Martín López, Jimena

2016-01-01

Los alimentos transgénicos son aquellos que proceden de un organismo modificado genéticamente. La introducción de este tipo de productos en nuestra dieta es un tema que genera controversia ya que en muchos casos no se conoce con exactitud los efectos que esta modificación puede tener en el ser humano. A lo largo de las páginas de este trabajo se explica la historia de la aparición de estos organismos gracias a procedimientos de ingeniería genética, en los que se modifican fragmentos de su ADN...

Sistema reprodutivo e diversidade genética de quatro espécies de Myrciaria (Myrtaceae, jabuticabeiras Reproductive system and genetic diversity of four species of Myrciaria (Myrtaceae, jabuticabeiras

Directory of Open Access Journals (Sweden)

Regina Célia Freitas Vilela

2012-12-01

Full Text Available A jabuticabeira é uma planta nativa da América do Sul e tem sofrido grande erosão genética devido à expansão da agricultura e desmatamento. Neste trabalho buscou-se investigar: a o sistema reprodutivo de quatro espécies de Myrciaria spp. (Myrciaria cauliflora, M. jaboticaba, M. coronata e M. trunciflora; b a compatibilidade de cruzamentos, utilizando tratamentos de polinização cruzada interespecíficos entre M. trunciflora x M. cauliflora e M. jaboticaba x M. coronata visando identificação de possíveis mecanismos de isolamento reprodutivos pós-zigóticos e c relacionar a distância genética destas espécies e outros 14 táxons conservados ex situ, através de marcadores moleculares tipo RAPD. Os tratamentos reprodutivos mostraram que as jabuticabeiras são espécies autocompatíveis e não se observa apomixia. Os cruzamentos bidirecionais de polinização entre M. trunciflora x M. cauliflora e entre M. jaboticaba x M. coronata, produziram taxa de obtenção de frutos de 22 a 27% cujas sementes produziram plântulas normais evidenciando a falta de barreiras genéticas entre as espécies testadas, além de frutos abortados precocemente. Esta compatibilidade de intercruzamentos pode ser explorada no melhoramento genético, visando a transferência de caracteres de interesse em genótipos agronomicamente superiores. Foi encontrada pouca diferenciação genética entre os diferentes táxons, sugerindo que a similaridade genética observada não é compatível com a similaridade morfológica e os principais caracteres de valor taxonômico são polimórficos dentro do gênero.The jabuticaba tree is a native plant from South America and has undergone genetic erosion due to agricultural expansion and deforestation. The present study aimed to investigate: a the reproductive system of four species of Myrciaria spp. (Myrciaria cauliflora, M. jaboticaba, M. coronata and M. trunciflora; b the compatibility of cross breeding using interspecific

Evaluation of the Hologic gen-probe PANTHER, APTIMA Combo 2 assay in a tertiary care teaching hospital.

Science.gov (United States)

Cheng, Annie; Kirby, James E

2014-03-01

To evaluate the performance of the Hologic Gen-Probe (San Diego, CA) PANTHER system. The performance of PANTHER was compared with the Hologic Gen-Probe TIGRIS and/or Roche (Indianapolis, IN) COBAS AMPLICOR systems through testing of patient specimens and the spiked-urine matrix. After discrepant resolution, PANTHER demonstrated a 99.3% (95% confidence interval [CI], 96.0%-99.9%) positive and 100% (98.5%-100.0%) negative agreement for Chlamydia trachomatis (CT) and 100% (96.6%-100.0%) positive and 100% (98.6%-100.0%) negative agreement for Neisseria gonorrhoeae (NG) for all male, female, unsexed, and NG-spiked female urine specimens combined. For other specimen types collectively, the PANTHER demonstrated 100% (95% CI, 90.6%-100.0%) positive and 100% (88.3%-100.0%) negative agreement for CT and 90.9% (62.8%-98.4%) positive and 100% (93.5%-100.0%) negative agreement for NG. Analytical sensitivity of the PANTHER in urine matrix was similar to the TIGRIS system. The PANTHER system provides an excellent new addition to options for detecting CT and NG, is appropriate for testing urine samples, and will facilitate high-throughput testing in the clinical laboratory.

Crescimento de genótipos de frangos tipo caipira

Directory of Open Access Journals (Sweden)

R. C. Veloso

2015-10-01

Full Text Available RESUMOObjetivou-se com este trabalho comparar o padrão de crescimento, mediante ajustes das respectivas curvas de crescimento por modelos não lineares, bem como estudar o desenvolvimento de cortes de carcaça em relação ao peso da carcaça em diferentes genótipos de frangos tipo caipira. Foram utilizados 840 pintos de um dia, machos, distribuídos em delineamento inteiramente ao acaso, dos seguintes genótipos da linhagem Redbro: Caboclo, Carijó, Colorpak, Gigante Negro, Pesadão Vermelho, Pescoço Pelado e Tricolor. As aves foram alojadas em 28 boxes, sendo 30 aves/boxe, em galpão de alvenaria com acesso a um piquete de 45m², com quatro repetições. O peso corporal individual dos frangos foi medido ao nascer, aos 14, 28, 42, 56, 70 e 84 dias de idade. Para a determinação das curvas de crescimento do peso corporal das aves, os dados coletados foram avaliados por meio dos modelos não lineares: Brody, Gompertz, Logístico, Richards e von Bertalanffy. Foi empregado o PROC NLIN do SAS, utilizando-se o método interativo de Gauss-Newton. Os critérios usados para escolha do modelo de melhor ajuste da curva de crescimento foram o coeficiente de determinação, o desvio padrão assintótico, o desvio médio absoluto dos resíduos e o índice assintótico. As análises para obtenção dos coeficientes alométricos foram realizadas por meio do PROC GLM do SAS para os genótipos Carijó, Colorpak, Pesadão Vermelho, Pescoço Pelado e Tricolor. Foram avaliados os pesos da carcaça, do peito, das coxas, das sobrecoxas, das pernas e das asas das aves abatidas aos 85 dias de idade. Apenas as equações propostas por Gompertz, von Bertalanffy e Logístico atingiram a convergência, e o modelo proposto por von Bertalanffy foi o mais adequado para descrever o crescimento dos genótipos de frangos caipiras. Todos os cortes avaliados apresentaram crescimento tardio em relação ao peso da carcaça em genótipos de frangos tipo caipira.

A Study on planning of the international collaboration foundation for the Advanced Nuclear Technology Development Project

Energy Technology Data Exchange (ETDEWEB)

Chang, Moon Hee; Kim, H. R.; Kim, H. J. and others

2005-03-15

Korea has participated in the international collaboration programs for the development of future nuclear energy systems driven by the countries holding advanced nuclear technology and Korea and U.S. have cooperated in the INERI. This study aimed mainly at developing the plan for participation in the collaborative development of the Gen IV, searching the participation strategy for INERI and the INPRO, and the international cooperation in these programs. Contents and scope of the study for successful achievement are as follows; Investigation and analysis of international and domestic trends related to advanced nuclear technologies, Development of the plan for collaborative development of the Gen IV and conducting the international cooperation activities, Support for the activities related to I-NERI between Korea and U.S. and conducting the international cooperation, International cooperation activities for the INPRO. This study can be useful for planning the research plan and setting up of the strategy of integrating the results of the international collaboration and the domestic R and D results by combining the Gen IV and the domestic R and D in the field of future nuclear technology. Futhermore, this study can contribute to establishing the effective foundation and broadening the cooperation activities not only with the advanced countries for acquisition of the advanced technologies but also with the developing countries for the export of the domestic nuclear energy systems.

A Study on planning of the international collaboration foundation for the Advanced Nuclear Technology Development Project

International Nuclear Information System (INIS)

Chang, Moon Hee; Kim, H. R.; Kim, H. J. and others

2005-03-01

Korea has participated in the international collaboration programs for the development of future nuclear energy systems driven by the countries holding advanced nuclear technology and Korea and U.S. have cooperated in the INERI. This study aimed mainly at developing the plan for participation in the collaborative development of the Gen IV, searching the participation strategy for INERI and the INPRO, and the international cooperation in these programs. Contents and scope of the study for successful achievement are as follows; Investigation and analysis of international and domestic trends related to advanced nuclear technologies, Development of the plan for collaborative development of the Gen IV and conducting the international cooperation activities, Support for the activities related to I-NERI between Korea and U.S. and conducting the international cooperation, International cooperation activities for the INPRO. This study can be useful for planning the research plan and setting up of the strategy of integrating the results of the international collaboration and the domestic R and D results by combining the Gen IV and the domestic R and D in the field of future nuclear technology. Futhermore, this study can contribute to establishing the effective foundation and broadening the cooperation activities not only with the advanced countries for acquisition of the advanced technologies but also with the developing countries for the export of the domestic nuclear energy systems

System Design Strategies of Post-Accident Monitoring System for a PGSFR in Korea

International Nuclear Information System (INIS)

Jang, Gwi-sook; Jeong, Kwang-il; Keum, Jong-yong; Seong, Seung-hwan

2013-06-01

Monitoring systems of a PGSFR (Prototype Gen-IV Sodium-cooled Fast Reactor) in Korea provide alarms, integrity information in the reactor building, sodium-water reaction information in the steam generator, fuel failure information, and supporting information for maintenance and inspection. In particular, a Post-Accident Monitoring System (PAMS) provides primary information for operators to assess the plant conditions and perform their role in bringing the plant to a safe condition during an accident. Some PAM variables can be allocated as more two types. It is important for system designers to confirm the suitability of the selection of PAM variables. In addition, the PAMS is a position 4 display against common cause failures of safety I and C systems. The position 4 display should be independent and diverse from the safety I and C systems. The diversity of safety I and C equipment has led to an increase in the design and verification and validation cost. Thus, this paper proposes the system design strategies on the PAMS design problems of the PGSFR in KOREA. The results will be input into a conceptual system design for the PAMS of the PGSFR in KOREA. (authors)

Internal combustion engine report: Spark ignited ICE GenSet optimization and novel concept development

Energy Technology Data Exchange (ETDEWEB)

Keller, J.; Blarigan, P. Van [Sandia National Labs., Livermore, CA (United States)

1998-08-01

In this manuscript the authors report on two projects each of which the goal is to produce cost effective hydrogen utilization technologies. These projects are: (1) the development of an electrical generation system using a conventional four-stroke spark-ignited internal combustion engine generator combination (SI-GenSet) optimized for maximum efficiency and minimum emissions, and (2) the development of a novel internal combustion engine concept. The SI-GenSet will be optimized to run on either hydrogen or hydrogen-blends. The novel concept seeks to develop an engine that optimizes the Otto cycle in a free piston configuration while minimizing all emissions. To this end the authors are developing a rapid combustion homogeneous charge compression ignition (HCCI) engine using a linear alternator for both power take-off and engine control. Targeted applications include stationary electrical power generation, stationary shaft power generation, hybrid vehicles, and nearly any other application now being accomplished with internal combustion engines.

Transformação genética em espécies florestais.

Directory of Open Access Journals (Sweden)

Claudia Studart-Guimarães

2010-08-01

Full Text Available A transformação genética, que compreende a introdução de genes exógenos de forma controlada no genoma de uma célula vegetal e posterior regeneração da planta transgênica, tem contribuído com os programas de melhoramento genético de plantas pela obtenção de genótipos com novas características de interesse. O melhoramento de espécies florestais é limitado por características intrínsecas a tais espécies, como a altura dos indivíduos e o ciclo longo de vida. A transformação genética constitui, portanto, uma alternativa para a obtenção de espécies florestais com características desejáveis em um menor espaço de tempo. Plantas transgênicas com resistência a determinadas pragas, com melhor qualidade de madeira, maior produção de biomassa, tolerância a herbicidas, entre outras características de interesse, já foram obtidas para diferentes espécies florestais de importância econômica como álamo, eucalipto e pinheiros em geral. Este trabalho mostra a importância da transformação genética, associada a outras técnicas biotecnológicas no melhoramento de espécies florestais, as técnicas de transformação mais utilizadas e as características que já foram introduzidas nessas espécies pela transformação.

Reporte de familias con neurofibromatosis y otras enfermedades genéticas

OpenAIRE

Orraca Castillo, Miladys; Licourt Otero, Deysi; Sánchez Álvarez de La Campa, Ana Isabel

2011-01-01

La neurofibromatosis tipo 1, es una enfermedad genética que primariamente afecta el desarrollo y crecimiento celular del sistema nervioso, clínicamente se caracteriza por máculas café con leche, neurofibromas, pecas en regiones no expuestas al sol, nódulos de Lisch, lesiones óseas y glioma óptico. En el presente trabajo se describen dos familias, en las cuales algunos individuos padecen esta enfermedad y otros miembros de la misma familia muestran una diferente enfermedad genética. La coexist...

Inventering av Suldalslågen. Produksjonspotensial for sjøvandrende laksefisk

OpenAIRE

Foldvik, Anders; Pettersen, Oskar

2017-01-01

Foldvik, A. & Pettersen, O. 2017. Inventering av Suldalslågen. Produksjonspotensial for sjøvandrende laksefisk. - NINA Kortrapport 75, 18 s. Reguleringen av Suldalslågen til kraftproduksjon har hatt negative effekter for habitat for laksefisk, blant annet i form av sedimentering og begroing av substratet. Disse prosessene har blitt forsøkt motvirket ved å ha en serie med spyleflommer på over 200 m3/s om høsten. På oppdrag fra Statkraft inverterte NINA oppvekst- og gyteforhold for laks i Su...

TrayGen: Arranging objects for exhibition and packaging

KAUST Repository

Yang, Yongliang; Huang, Qixing

2013-01-01

We present a framework, called TrayGen, to generate tray designs for the exhibition and packaging of a collection of objects. Based on principles from shape perception and visual merchandising, we abstract a number of design guidelines on how

Genética do transtorno bipolar Genetics of bipolar disorder

Directory of Open Access Journals (Sweden)

Leandro Michelon

2004-10-01

Full Text Available O Transtorno bipolar (TB possui alta prevalência na população mundial e causa perdas significativas na vida dos portadores. É uma doença cuja herança genética se caracteriza por mecanismos complexos de transmissão envolvendo múltiplos genes. Na tentativa de identificar genes de vulnerabilidade para o TB, várias estratégias de investigação genética têm sido utilizadas. Estudos de ligação apontam diversas regiões cromossômicas potencialmente associadas ao TB, cujos marcadores ou genes podem ser candidatos para os estudos de associação. Genes associados aos sistemas monoaminérgicos e vias de sinalização intracelulares são candidatos para investigação da etiologia genética do TB. Novas técnicas de mapeamento de expressão gênica em tecidos especializados apontam para novos genes cujas mutações possam ser responsáveis pelo aparecimento da doença. Em virtude da complexidade do modo de transmissão do TB e de sua heterogeneidade fenotípica, muitas dificuldades são encontradas na determinação desses genes de vulnerabilidade. Até o momento, há apenas resultados preliminares identificando alguns genes associados à vulnerabilidade para desenvolver o TB. Entretanto, a compreensão crescente dos mecanismos epigenéticos de controle da expressão gênica e a abordagem dimensional dos transtornos mentais podem colaborar nas investigações futuras em genética psiquiátrica.Bipolar disorder (BD is a worldwide highly prevalent mental disease. This disorder has a genetic inheritance characterized by complex transmission mechanisms involving multiple genes. Many investigation strategies have been put forward in order to identify BD susceptibility genes. Linkage studies reveal markers and candidate genes for the association studies. Monoaminergic system genes and intracellular signaling pathway genes are also important candidates to be investigated in the etiology of this disorder. Recent techniques of gene expression

Oxochloroalkoxide of the Cerium (IV and Titanium (IV as oxides precursor

Directory of Open Access Journals (Sweden)

Machado Luiz Carlos

2002-01-01

Full Text Available The Cerium (IV and Titanium (IV oxides mixture (CeO2-3TiO2 was prepared by thermal treatment of the oxochloroisopropoxide of Cerium (IV and Titanium (IV. The chemical route utilizing the Cerium (III chloride alcoholic complex and Titanium (IV isopropoxide is presented. The compound Ce5Ti15Cl16O30 (iOPr4(OH-Et15 was characterized by elemental analysis, FTIR and TG/DTG. The X-ray diffraction patterns of the oxides resulting from the thermal decomposition of the precursor at 1000 degreesC for 36 h indicated the formation of cubic cerianite (a = 5.417Å and tetragonal rutile (a = 4.592Å and (c = 2.962 Å, with apparent crystallite sizes around 38 and 55nm, respectively.

Polimorfismos del gen ob en bovinos de raza holstein en la Comarca Lagunera, México

OpenAIRE

Sarai S. Mendoza-Retana; Miguel A. Gallegos-Robles; Uriel González-Salas; José L. García-Hernández; Manuel Fortis-Hernández; Cirilo Vázquez-Vázquez; Héctor I. Trejo-Escareño

2017-01-01

La Comarca Lagunera es la cuenca lechera más importante de México. En la actualidad se están utilizando diversas técnicas que permiten evaluar genéticamente el animal a una edad temprana, permitiendo seleccionar futuros reproductores con características deseables. Entre los genes relacionados con la producción de leche, se encuentran el gen Ob también llamado gen Leptina el cual actúa sobre el sistema nervioso central y tejidos periféricos jugando un papel muy importante ...

Evaluación genética de los salmónidos asturianos como recurso natural

OpenAIRE

Abad García, David

2012-01-01

En este proyecto se analiza la estructura genética de los stocks utilizados para la repoblación de trucha común en el Principado de Asturias, pertenecientes a dos piscifactorías diferentes, con el fin de establecer si los repobladores cumplen con la normativa vigente sobre la liberación de individuos no autóctonos al medio natural, que está actualmente prohibida. Para ello se utiliza como marcador genético el gen del enzima lactato deshidrogenasa LDH-C, que permite diferenciar las poblaciones...

Modelling and simulation of the fuel cell energy source for the Hydro-Gen vehicle; Modelisation et simulation de la source d'energie a pile a combustible du vehicule Hydro-Gen

Energy Technology Data Exchange (ETDEWEB)

Schott, P.; Baurens, P. [CEA Grenoble, Dept. d' Etudes des Materiaux, DEM, 38 (France); Poirot, J.Ph. [PSA/DRIA/SEE, 78 - Velizy Villacoublay (France)

2000-07-01

A fuel cell generating set is a complex system in which the interactions between the different elements are chemical, hydraulic, thermal, mechanical and electric. The implementation and the optimization of such a system cannot be limited to the study of each element; the system analysis and then the modelling and the dynamical simulation are necessarily required. The bond-graphs theory is particularly well adapted to the multiplicity of the involved phenomena. In this article is presented the modelling used for the generating set of the Hydro-Gen plan. Some representative examples are given as well as the first qualitative results of the simulations. (O.M.)

Objective Provision Tree for K-DEMO

International Nuclear Information System (INIS)

Oh, Kyemin; Kang, Myung-suk; Heo, Gyunyoung; Kim, Hyoung-chan

2014-01-01

In current nuclear field based on technology-neutral approach, safety principles and design have been considered for Generation IV (Gen-IV) nuclear power plants in parallel. This strategy can save resource, time, and manpower while keeping achievable safety. For this reason, the studies related with safety affecting significant design parameters for planned construction or fusion plants was needed and required even though K-DEMO is staying in pre-conceptual design phase. Objective Provision Tree (OPT) is one of the tools of Integrated Safety Assessment Methodology (ISAM) developed by Risk and Safety Working Group (RSWG) for design and assessment of Gen-IV. This is suitable tool to recognize and investigate safety issues from previous engineering experience. The purpose of this paper is to suggest multiple barriers/critical safety function and to describe the current status of the OPT for the conceptual design of K-DEMO. In this paper, critical safety functions were defined and OPT for K-DEMO was described and performed. We have carried out researches related to safety for fusion power plant in collaboration with the academies funded by NFRI during the past 4 years. As part of this research, Integrated Safety Assessment Methodology (ISAM), which was used to develop GEN-IV nuclear systems, was used to determine the technical safety issues and regulatory requirements for K-DEMO. OPT is one of ISAM tools

Lessons learned from Gen II NPP staffing approaches applicable to new reactors - 15003

International Nuclear Information System (INIS)

Goodnight, C.

2015-01-01

This paper discusses lessons learned from the operation of the Gen II fleet of existing nuclear power plants (NPPs), in terms of staffing, that can be applied to the final design, deployment, and operation of new reactor designs. The most significant of these lessons is the need to appropriately staff the facility, having the right number of people with the required skills and experience. This begs the question of how to identify those personnel requirements. For NPPs, there are five key factors that ultimately will determine the effectiveness and costs of operating nuclear power plants (NPPs): 1) The Nuclear Steam Supply System (NSSS) and the layout of the plant site; 2) The processes which the operating organization applies; 3) The organizational structure of the operating organization; 4) The organizational culture of the operating organization, and 5) The regulatory framework under which the licensee must operate. In summary, this paper identifies opportunities to minimize staffing and costs learned from Gen II NPPs that may be applicable for new nuclear plants. (author)

POTENSI GEN dtx DAN dtxR SEBAGAI MARKER UNTUK DETEKSI DAN PEMERIKSAAN TOKSIGENISITAS Corynebacterium diphtheriae

Directory of Open Access Journals (Sweden)

Sunarno Sunarno

2013-05-01

Full Text Available Abstract.   Corynebacterium diphtheriae is the causative agent of diphtheria. The main virulence determinant of the bacteria is diphtheria toxin, the cause of the systemic complication seen with diphtheria. Production of diphtheria toxin by toxigenic strain encoded by dtx/tox gene and repressed by dtxR gene. Gold standard for bacterial toxigenicity test carried out by conventional methods (Elek test, Guinea pig and vero cell cytotoxicity. However, Elek test have variety result, time consume and problem of the reagent availability. On the other hand, the animal (Guinea pig testing was opposed by many animal lovers and the vero cell cytotoxicity test require high cost. The study purposed to evaluate the using of dtx and dtxR genes as a detection marker of C.diphtheriae and bacterial toxigenicity test simultaneusly by Multiplex PCR. The study examined 44 bacterial and fungal isolates, included 22 C.diphtheriae (4 reference strains and 18 clinical isolates, 5 other specieses of Corynebacterium  (reference strains and 17 non-Corynebacterium (10 reference strains and 7 stock cultures . All of sample were examined by Multiplex PCR for 2 primer pairs targeted dtx and dtxR genes. The study showed that the Multiplex PCR for dtx and dtxR as target genes able to detect all of sample correctly thus concluded that dtx and dtxR genes could be used as a marker for alternative detection and toxigenicity test of C.diphtheriae by Multiplex PCR rapidly and accuratelly. Key words: Corynebacterium diphtheriae, dtx, dan dtxR Abstrak. Corynebacterium diphtheriae merupakan agen penyebab penyakit difteri.. Faktor virulensi utama  C. diphtheriae adalah toksigenisitas (kemampuan memproduksi toksin bakteri toxin. Produksi toksin diatur seperangkat gen yang disebut gen tox/dtx dan diregulasi oleh gen dtxR. Gold standard untuk pemeriksaan toksigenisitas C.diphtheriae adalah dengan metode konvensional (Elek test, Guinea pig dan vero cell cytotoxigenicity,namun  Elek test

Incidência de tripes em genótipos de cebola

Directory of Open Access Journals (Sweden)

Paulo Antonio de Souza Gonçalves

2017-05-01

Full Text Available Os objetivos deste estudo foram avaliar a incidência de tripes em genótipos de cebola, verificar sua correlação com o teor de clorofila, arquitetura e coloração foliar, e produtividade. O experimento foi conduzido na Epagri, Estação Experimental de Ituporanga, SC, Brasil, na safra de 2015. O número de genótipos comerciais ou em desenvolvimento avaliados foi 48, sendo doze híbridos e 36 de polinização livre. A incidência de tripes foi semelhante na maioria dos genótipos. As exceções foram os híbridos precoces Roxa 10039 e 10160, que apresentaram menores notas de incidência que RDW Luthy e Conesul. A arquitetura foliar mais aberta associada com a cor verde clara favoreceu uma menor incidência de tripes. Os cultivares de polinização livre e com origem no programa de melhoramento da Epagri (Superprecoce-Agroecológica, Bola Precoce-Agroecológica, Juporanga-Agroecológica, Valessul, Bola Suprema e Crioula Alto Vale foram os mais produtivos.

Design and application of the MARK IV scanning system for radionuclide computed tomography of the brain

International Nuclear Information System (INIS)

Kuhl, D.E.; Hoffman, E.J.; Phelps, M.E.; Ricci, A.; Reivich, M.

1976-01-01

The MARK IV radioisotope scanning system was built to provide fast and accurate radionuclide computed tomography (RCT). It is designed primarily for detecting commonly available radioactive labels such as /sup 99m/Tc, but it is also adapted to detecting positron emitters such as 18 F. The system has interlaced convergent collimation in a 4-sided arrangement of 32-independent detectors which continuously rotate as a unit, detecting, processing, and displaying the reconstructed data while the study progresses

Data flow methods for dynamic system simulation - A CSSL-IV microcomputer network interface

Science.gov (United States)

Makoui, A.; Karplus, W. J.

1983-01-01

A major problem in employing networks of microcomputers for the real-time simulation of complex systems is to allocate computational tasks to the various microcomputers in such a way that idle time and time lost in interprocess communication is minimized. The research reported in this paper is directed to the development of a software interface between a higher-level simulation language and a network of microcomputers. A CSSL-IV source program is translated to a data flow graph. This graph is then analyzed automatically so as to allocate computing tasks to the various processors.

Caracterização de genótipos de cebola com a utilização de marcadores moleculares RAPD

Directory of Open Access Journals (Sweden)

Gerson Henrique Wamser

Full Text Available A divergência genética foi avaliada entre quinze genótipos de cebola cultivados em Santa Catarina, com a utilização de marcadores moleculares RAPD. Onze oligonucleotídeos iniciadores da série Operon Technologies foram utilizados e produziram 35 marcadores, destes, 28 foram polimórficos. Os produtos da amplificação foram visualizados em gel de agarose 1,4%, corado com brometo de etídeo. Uma matriz de similaridade utilizando-se o coeficiente de Jaccard foi construída a partir dos dados moleculares. Um dendrograma foi gerado para melhor visualização da similaridade genética através do método de agrupamento UPGMA. Três grupos foram formados utilizando o coeficiente de similaridade 0,6 como ponto de corte. O primeiro grupo reuniu os genótipos Super Superprecoce e Gauchinha. O segundo grupo reuniu doze genótipos. Dentro desse grupo, os genótipos Bella Vista e Bella Dura foram os que apresentaram o maior coeficiente de similaridade, em torno de 0,89. Bela Vista e Superprecoce, Catarina e o híbrido Bella Vista, com coeficiente de similaridade de 0,88 entre os pares. O terceiro grupo apresentou apenas o genótipo Crioula Roxa, que obteve o menor valor (0,31 para o coeficiente de similaridade. Tendo em vista os resultados obtidos, cruzamentos entre os genótipos do primeiro e segundo grupo e destes com o genótipo Crioula Roxa, podem ser melhores por apresentarem maior divergência entre si. A técnica de RAPD mostrou-se eficaz na caracterização molecular dos genótipos de cebola, evidenciando que existe variabilidade entre os genótipos estudados.

Community Microgrid Based on Micro-Wind Generation System

OpenAIRE

Mariam, Lubna; Basu, Malabika; Conlon, Michael

2013-01-01

Penetration of renewable energy sources (such as solar/wind) are being explored mostly as micro power generation (μGen) or mega power plant system. In recent years, emphasis has been given on Microgrid (μGrid) systems because of their few advantages over μGen systems in terms of power quality, stability, reliability, economics etc. But the commercial installation of the μGrid system is not yet progressing significantly. This paper presents the techno-economic aspects of μGen and μGrid systems...

InGen Inconsistencies: The "Dinosaurs" Of Jurassic Park May Not Be What The Corporation Claims

Science.gov (United States)

Haupt, R. J.; Traer, M. M.

2017-12-01

InGen has made and continues to make dubious claims about proprietary technology developed to clone non-avian dinosaurs for exhibition within their "Jurassic Park." Notably, there are several inconsistencies between their claims for how their technology works and what has been observed within the park. Here we investigate several of these inconsistencies in the hopes that it will push for increased transparency between corporations and academia. First, we highlight a disconnect between supposedly Jurassic amber used for dinosaur DNA extraction and the overwhelming presence of Late Cretaceous dinosaurs within the park. Further, InGen's mining operations only publicly operate in Jurassic-aged formations of the Dominican Republic, which clashes with the presence of Velociraptor and Gallimimus, known only from Mongolia. Second, the park contains seemingly full-grown adult specimens despite InGen's claims that they first successfully cloned a prehistoric animal in 1984, though there is no publicly available information as to what animal this was. That the park was nearly ready to open by 1993 precludes the presence of fully mature dinosaurs and suggests that InGen might be misrepresenting their technologies. Third, we must point out that fossil DNA denatures to the point of uselessness within thousands, not millions, of years. Additionally, the use of anuran DNA to fill in gaps from fossil dinosaurian DNA is a dubious choice given that more closely related organisms are available. Either there is an unexplained reason for this choice, or little attention has been paid to dinosaurian phylogeny by InGen geneticists. Finally, rumors of a secret InGen project to produce a dinosaur not currently known to paleontologists suggests one of two things: they were able to find DNA from a dinosaur previously unknown in the fossil record, which is highly plausible if their techniques are valid, or that InGen is able to artificially manipulate DNA to a degree far beyond what other

Gridded precipitation dataset for the Rhine basin made with the genRE interpolation method

NARCIS (Netherlands)

Osnabrugge, van B.; Uijlenhoet, R.

2017-01-01

A high resolution (1.2x1.2km) gridded precipitation dataset with hourly time step that covers the whole Rhine basin for the period 1997-2015. Made from gauge data with the genRE interpolation scheme. See "genRE: A method to extend gridded precipitation climatology datasets in near real-time for

GenSVM: a generalized multiclass support vector machine

NARCIS (Netherlands)

G.J.J. van den Burg (Gertjan); P.J.F. Groenen (Patrick)

2016-01-01

textabstractTraditional extensions of the binary support vector machine (SVM) to multiclass problems are either heuristics or require solving a large dual optimization problem. Here, a generalized multiclass SVM is proposed called GenSVM. In this method classification boundaries for a K-class

Análisis genético del virus peruano de la fiebre amarilla

Directory of Open Access Journals (Sweden)

Carlos Yábar V

2002-01-01

Full Text Available Objetivo: Determinar las variantes genéticas de aislamientos del virus peruano de la Fiebre Amarilla (FA. Materiales y métodos: la región carboxiterminal del gen de la envoltura (E de cinco aislamientos de FA obtenidas de pacientes provenientes de Ayacucho 1978 (PER1, Junín 1995 (PER2, Cerro de Pasco (PER3, Cusco (1998 y San Martín (1999 fue amplificada por PCR, secuenciada y analizada con programas software de ADN. Resultados: el índice de similaridad de la secuencia de nucleótidos entre los cinco aislamientos reveló valores oscilantes entre 94,3% y 99,3%, mientras que la secuencia de aminoácidos presentó valores entre 97,6% y 99,7% de similaridad. El análisis filogenético demostró una distancia genética entre 0,40 y 6,50 mediante la secuencia de nucleótidos y a través de la secuencia de aminoácidos se observó un rango de 0,30 y 4,29. Sin embargo, las secuencias correspondientes a los sitios de glicosilación y a los epítopes de reconocimiento humoral fueron conservadas entre los cinco aislamientos, con excepción de algunos aislamientos de referencia reportados por otros autores. Conclusiones: los virus de FA peruanos forman un grupo filogenético distinto a otros virus de FA sudamericanos, basados en el análisis genéticos del gen E.

Genome-scale data suggest reclassifications in the Leisingera-Phaeobacter cluster including proposals for Sedimentitalea gen. nov. and Pseudophaeobacter gen. nov.

Directory of Open Access Journals (Sweden)

Sven eBreider

2014-08-01

Full Text Available Earlier phylogenetic analyses of the marine Rhodobacteraceae (class Alphaproteobacteria genera Leisingera and Phaeobacter indicated that neither genus might be monophyletic. We here used phylogenetic reconstruction from genome-scale data, MALDI-TOF mass-spectrometry analysis and a re-assessment of the phenotypic data from the literature to settle this matter, aiming at a reclassification of the two genera. Neither Phaeobacter nor Leisingera formed a clade in any of the phylogenetic analyses conducted. Rather, smaller monophyletic assemblages emerged, which were phenotypically more homogeneous, too. We thus propose the reclassification of Leisingera nanhaiensis as the type species of a new genus as Sedimentitalea nanhaiensis gen. nov., comb. nov., the reclassification of Phaeobacter arcticus and Phaeobacter leonis as Pseudophaeobacter arcticus gen. nov., comb. nov. and Pseudophaeobacter leonis comb. nov., and the reclassification of Phaeobacter aquaemixtae, Phaeobacter caeruleus and Phaeobacter daeponensis as Leisingera aquaemixtae comb. nov., Leisingera caerulea comb. nov. and Leisingera daeponensis comb. nov. The genera Phaeobacter and Leisingera are accordingly emended.

Targeted NextGen Capabilities for 2025

Science.gov (United States)

2011-11-01

increased arrival capacity to single runways by reducing longitudinal wake separation standards for Instrument Flight Rules ( IFR ) operations under certain...b. ABSTRACT unclassified c. THIS PAGE unclassified Standard Form 298 (Rev. 8-98) Prescribed by ANSI Std Z39-18 Targeted NextGen Capabilities...The examples cited are not intended to cover every aircraft and every flight. In some instances, the available capabilities for 2025 will not be

PowerGen plc report and accounts 1995

Energy Technology Data Exchange (ETDEWEB)

NONE

1995-12-31

Detailed financial results are presented for the United Kingdom power generation company PowerGen for the year ended 2 April 1995. A review is given of operating and financial performance. Significant reductions in operating costs and improvements in productivity have been achieved. Diversity of fuels and plant portfolio has been enhanced by building 3000 MW of gas fired CCGT plant. Investment in coal import facilities has increased access to international coal markets. Environmental performance has improved with further reductions in SO{sub 2}, NO{sub x} and CO{sub 2} emissions. Overseas projects include construction of 990 MW CCGT power station in Portugal and a contract to build the 1200 MW Paiton 2 coal-fired power station in Indonesia. Investment in lignite mining and power generation assets of MIBRAG in Germany is contributing to profits. PowerGen`s five year contract for coal supply was assigned to RJB Mining (UK) Ltd. during the year. Stocks of coal fell during the year and further reductions are expected during 1995/96.

Algoritmo genético permutacional para el despliegue y la planificación de sistemas de tiempo real distribuidos

Directory of Open Access Journals (Sweden)

Ekain Azketa

2013-07-01

Full Text Available Resumen: El despliegue y la planificación de tareas y mensajes en sistemas de tiempo real distribuidos son problemas NP-difíciles (NP- hard, por lo que no existen métodos óptimos para solucionarlos en tiempo polinómico. En consecuencia, estos problemas son adecuados para abordarse mediante algoritmos genéricos de búsqueda y optimización. En este artículo se propone un algoritmo genético multiobjetivo basado en una codificación permutacional de las soluciones para abordar el despliegue y la planificación de sistemas de tiempo real distribuidos. Además de desplegar tareas en computadores y de planificar tareas y mensajes, este algoritmo puede minimizar el número de computadores utilizados, la cantidad de recursos computacionales y de comunicaciones empleados y el tiempo de respuesta de peor caso medio de las aplicaciones. Los resultados experimentales muestran que este algoritmo genético permutacional puede desplegar y planificar sistemas de tiempo real distribuidos de forma satisfactoria y en tiempos razonables. Abstract: The deployment and scheduling of tasks and messages in distributed real-time systems are NP-hard problems, so there are no optimal methods to solve them in polynomial time. Consequently, these problems are suitable to be approached with generic search and optimisation algorithms. In this paper we propose a multi-objective genetic algorithm based on a permutational solution encoding for the deployment and scheduling of distributed real-time systems. Besides deploying and scheduling tasks and messages, the algorithm can minimize the number of the used computers, the utilization of computing and networking resources and the average worst-case response times of the applications. The experiments show that this genetic algorithm can successfully synthesize complex distributed real-time systems in reasonable times. Palabras clave: Sistemas de tiempo real, Algoritmos de planificaci

Description of Sharon gen. nov. for the Chilean species Asaphes amoenus Philippi, 1861 (Coleoptera: Elateridae

Directory of Open Access Journals (Sweden)

Elizabeth T. Arias-Bohart

2015-10-01

Full Text Available Sharon gen. nov. is here described to include Asaphes? amoenus Philippi, 1861 comb. nov. from Chile. A redescription of the species is based on the female holotype and material from different geographic locations. Candèze (1891 placed Asaphes amoenus and Parasaphes elegans in the suprageneric group Asaphites. We discuss differences between Sharon gen. nov. and Hemicrepidius Germar, 1839, where Asaphes amoenus was later placed by Blackwelder (1944. Based on morphological characters, Sharon gen. nov. appears to be related to Parasaphes Candèze, 1881, Wynarka Calder, 1986, and Tasmanelater Calder, 1996, all from Australia, suggesting Gondwanan relationships.

Actividad del Sistema Renina-Angiotensina en relación con sus polimorfismos genéticos

OpenAIRE

Morcillo Hidalgo, Luis

2015-01-01

La realización del presente estudio sobre sujetos jóvenes y sanos no hipertensos tiene dos objetivos primordiales: El primero es analizar la relación de los polimorfismos de los genes del Sistema Renina-Angiotensina, el M235T del gen del angiotensinógeno, el Inserción/Delección del gen de la ECA y el A1166C del gen del receptor AT1 para la angiotensina II, con los niveles en plasma de angiotensina I, angiotensina II y angiotensina-(1-7), todas sustancias peptídicas activas del sistema E...

Diagnostico genético prenatal y aborto. Dos cuestiones de eugenesia y discriminación

OpenAIRE

Villela Cortés, Fabiola; Linares Salgado, Jorge E.

2012-01-01

Los avances en genética seguidos de las nuevas tecnologías en la detección temprana de afecciones genéticas conllevan dilemas bioéticos sobre el uso adecuado de estas técnicas, la información que se le da a la mujer embarazada y la decisión que ella tomará al recibirla. Detectar a tiempo anomalías genéticas permite, en algunas ocasiones, el inicio de un tratamiento adecuado que permita que el niño por nacer no desarrolle una enfermedad discapacitante, como el caso de la fenilcetonuria, o una ...

DNA Delivery and Genomic Integration into Mammalian Target Cells through Type IV A and B Secretion Systems of Human Pathogens

Directory of Open Access Journals (Sweden)

Dolores L. Guzmán-Herrador

2017-08-01

Full Text Available We explore the potential of bacterial secretion systems as tools for genomic modification of human cells. We previously showed that foreign DNA can be introduced into human cells through the Type IV A secretion system of the human pathogen Bartonella henselae. Moreover, the DNA is delivered covalently attached to the conjugative relaxase TrwC, which promotes its integration into the recipient genome. In this work, we report that this tool can be adapted to other target cells by using different relaxases and secretion systems. The promiscuous relaxase MobA from plasmid RSF1010 can be used to deliver DNA into human cells with higher efficiency than TrwC. MobA also promotes DNA integration, albeit at lower rates than TrwC. Notably, we report that DNA transfer to human cells can also take place through the Type IV secretion system of two intracellular human pathogens, Legionella pneumophila and Coxiella burnetii, which code for a distantly related Dot/Icm Type IV B secretion system. This suggests that DNA transfer could be an intrinsic ability of this family of secretion systems, expanding the range of target human cells. Further analysis of the DNA transfer process showed that recruitment of MobA by Dot/Icm was dependent on the IcmSW chaperone, which may explain the higher DNA transfer rates obtained. Finally, we observed that the presence of MobA negatively affected the intracellular replication of C. burnetii, suggesting an interference with Dot/Icm translocation of virulence factors.

Commissioning and Performance Analysis of WhisperGen Stirling Engine

Science.gov (United States)

Pradip, Prashant Kaliram

Stirling engine based cogeneration systems have potential to reduce energy consumption and greenhouse gas emission, due to their high cogeneration efficiency and emission control due to steady external combustion. To date, most studies on this unit have focused on performance based on both experimentation and computer models, and lack experimental data for diversified operating ranges. This thesis starts with the commissioning of a WhisperGen Stirling engine with components and instrumentation to evaluate power and thermal performance of the system. Next, a parametric study on primary engine variables, including air, diesel, and coolant flowrate and temperature were carried out to further understand their effect on engine power and efficiency. Then, this trend was validated with the thermodynamic model developed for the energy analysis of a Stirling cycle. Finally, the energy balance of the Stirling engine was compared without and with heat recovery from the engine block and the combustion chamber exhaust.

Transuranium perrhenates: Np(IV), Pu(IV) and (III), Am (III)

International Nuclear Information System (INIS)

Silvestre, Jean-Paul; Freundlich, William; Pages, Monique

1977-01-01

Synthesis in aqueous solution and by solid state reactions, crystallographical characterization and study of the stability of some transuranium perrhenates: Asup(n+)(ReO 4 - )sub(n) (A=Np(IV), Pu(IV), Pu(III), Am(III) [fr

GenGIS 2: geospatial analysis of traditional and genetic biodiversity, with new gradient algorithms and an extensible plugin framework.

Directory of Open Access Journals (Sweden)

Donovan H Parks

Full Text Available GenGIS is free and open source software designed to integrate biodiversity data with a digital map and information about geography and habitat. While originally developed with microbial community analyses and phylogeography in mind, GenGIS has been applied to a wide range of datasets. A key feature of GenGIS is the ability to test geographic axes that can correspond to routes of migration or gradients that influence community similarity. Here we introduce GenGIS version 2, which extends the linear gradient tests introduced in the first version to allow comprehensive testing of all possible linear geographic axes. GenGIS v2 also includes a new plugin framework that supports the development and use of graphically driven analysis packages: initial plugins include implementations of linear regression and the Mantel test, calculations of alpha-diversity (e.g., Shannon Index for all samples, and geographic visualizations of dissimilarity matrices. We have also implemented a recently published method for biomonitoring reference condition analysis (RCA, which compares observed species richness and diversity to predicted values to determine whether a given site has been impacted. The newest version of GenGIS supports vector data in addition to raster files. We demonstrate the new features of GenGIS by performing a full gradient analysis of an Australian kangaroo apple data set, by using plugins and embedded statistical commands to analyze human microbiome sample data, and by applying RCA to a set of samples from Atlantic Canada. GenGIS release versions, tutorials and documentation are freely available at http://kiwi.cs.dal.ca/GenGIS, and source code is available at https://github.com/beiko-lab/gengis.

Scylla IV-P theta pinch

International Nuclear Information System (INIS)

Bailey, A.G.; Chandler, G.I.; Ekdahl, C.A. Jr.; Lillberg, J.W.; Machalek, M.D.; Seibel, F.T.

1976-01-01

Scylla IV-P is a flexible, linear theta pinch designed to investigate high-density linear concepts, end-stoppering, alternate heating methods, and plasma injection techniques relevant to a pure fusion reactor and/or a fusion-fission hybrid system. The construction and experimental arrangement of the device are briefly described

AtlA Functions as a Peptidoglycan Lytic Transglycosylase in the Neisseria gonorrhoeae Type IV Secretion System▿

OpenAIRE

Kohler, Petra L.; Hamilton, Holly L.; Cloud-Hansen, Karen; Dillard, Joseph P.

2007-01-01

Type IV secretion systems require peptidoglycan lytic transglycosylases for efficient secretion, but the function of these enzymes is not clear. The type IV secretion system gene cluster of Neisseria gonorrhoeae encodes two peptidoglycan transglycosylase homologues. One, LtgX, is similar to peptidoglycan transglycosylases from other type IV secretion systems. The other, AtlA, is similar to endolysins from bacteriophages and is not similar to any described type IV secretion component. We chara...

Thermal fluid dynamics study of nuclear advanced reactors of high temperature using RELAP5-3D; Estudo termofluidodinâmico de reatores nucleares avançados de alta temperatura utilizando o RELAP5-3D

Energy Technology Data Exchange (ETDEWEB)

Scari, Maria Elizabeth

2017-07-01

Fourth Generation nuclear reactors (GEN-IV) are being designed with special features such as intrinsic safety, reduction of isotopic inventory and use of fuel in proliferation-resistant cycles. Therefore, the investigation and evaluation of operational and safety aspects of the GEN-IV reactors have been the subject of numerous studies by the international community and also in Brazil. In 2008, in Brazil, was created the National Institute of Science and Technology of Innovative Nuclear Reactors, focusing on studies of projects and systems of new generation reactors, which included GEN-IV reactors as well as advanced PWR (Pressurized Water Reactor) concepts. The Department of Nuclear Engineering of the Federal University of Minas Gerais (DEN-UFMG) is a partner of this Institute, having started studies on the GEN-IV reactors in the year 2007. Therefore, in order to add knowledge to these studies, in this work, three projects of advanced reactors were considered to verify the simulation capability of the thermo-hydraulic RELAP5-3D code for these systems, either in stationary operation or in transient situations. The addition of new working fluids such as ammonia, carbon dioxide, helium, hydrogen, various types of liquid salts, among them Flibe, lead, lithium-bismuth, lithium-lead, was a major breakthrough in this version of the code, allowing also the simulation of GEN-IV reactors. The modeling of the respective core of an HTTR (High Temperature Engineering Test Reactor), HTR-10 (High Temperature Test Module Reactor) and LS-VHTR (Liquid-Salt-Cooled Very-High-Temperature Reactor) were developed and verified in steady state comparing the values found through the calculations with reference data from other simulations, when it is possible. The first two reactors use helium gas as coolant and the LS-VHTR uses a mixture of 66% LiF and 34% of BeF{sub 2}, the LiF-BeF{sub 2}, also know as Flibe. All the studied reactors use enriched uranium as fuel, in form of TRISO

Thermal fluid dynamics study of nuclear advanced reactors of high temperature using RELAP5-3D

International Nuclear Information System (INIS)

Scari, Maria Elizabeth

2017-01-01

Fourth Generation nuclear reactors (GEN-IV) are being designed with special features such as intrinsic safety, reduction of isotopic inventory and use of fuel in proliferation-resistant cycles. Therefore, the investigation and evaluation of operational and safety aspects of the GEN-IV reactors have been the subject of numerous studies by the international community and also in Brazil. In 2008, in Brazil, was created the National Institute of Science and Technology of Innovative Nuclear Reactors, focusing on studies of projects and systems of new generation reactors, which included GEN-IV reactors as well as advanced PWR (Pressurized Water Reactor) concepts. The Department of Nuclear Engineering of the Federal University of Minas Gerais (DEN-UFMG) is a partner of this Institute, having started studies on the GEN-IV reactors in the year 2007. Therefore, in order to add knowledge to these studies, in this work, three projects of advanced reactors were considered to verify the simulation capability of the thermo-hydraulic RELAP5-3D code for these systems, either in stationary operation or in transient situations. The addition of new working fluids such as ammonia, carbon dioxide, helium, hydrogen, various types of liquid salts, among them Flibe, lead, lithium-bismuth, lithium-lead, was a major breakthrough in this version of the code, allowing also the simulation of GEN-IV reactors. The modeling of the respective core of an HTTR (High Temperature Engineering Test Reactor), HTR-10 (High Temperature Test Module Reactor) and LS-VHTR (Liquid-Salt-Cooled Very-High-Temperature Reactor) were developed and verified in steady state comparing the values found through the calculations with reference data from other simulations, when it is possible. The first two reactors use helium gas as coolant and the LS-VHTR uses a mixture of 66% LiF and 34% of BeF 2 , the LiF-BeF 2 , also know as Flibe. All the studied reactors use enriched uranium as fuel, in form of TRISO (Tristructural

The affinity plutonium(IV) for nitrogen donor ligands

International Nuclear Information System (INIS)

Jarvis, N.V.; Hancock, R.D.

1994-01-01

Established ligand design principles are used to predict the solution chemistry of Pu(IV) with nitrogen donor ligands which do not contain carboxylate donors. pK a 's of the nitrogen donors are lowered by addition of hydroxyalkyl groups causing Pu(IV) to have a greater affinity for these ligands than for hydroxide. Potentiometric studies using the ligands N,N,N'N',N''-pentakis(2-hydroxypropyl)-1,4,7-triazaheptane; N,N,N',N',N''-pentakis(2-hydroxyethyl)-1,4,7-triazaheptane; N,N,N',N',N'-tetrakis(2-hydroxyethyl)-1,2-diaminoethane; N,N,N',N'-tetrakis(2-hydroxyethyl)-trans-1,2-diaminocyclohexane; 1,4,8,11-tetrakis(2-hydroxyethyl)-1,4,8,11-tetraazacyclotetradecane and N,N-bis(2-hydroxyethyl)glycine with Pu(IV) showed that Pu(IV) has a considerable aqueous solution chemistry with these ligands. Data were processed by the ESTA library of programs and stability constants for all the systems are reported. Implications for selective ligand design for Pu(IV) are discussed. (orig.)

XEUS: Exploratory Energy Utilization Systemic s for Fission Fusion Hybrid Application

International Nuclear Information System (INIS)

Suh, Kune Y.; Jeong, Wi S.; Son, Hyung M.

2008-01-01

World energy outlook requires environmental friendliness, sustain ability and improved economic feasibility. The Exploratory Energy Utilization Systemic s (XEUS) is being developed at the Seoul National University (SNU) to satisfy these demands. Generation IV (Gen IV) and fusion reactors are considered as candidates for the primary system. Battery Omnibus Reactor Integral System (BORIS) is a liquid-metal cooled fast reactor which is one of the Gen IV concepts. Fusion Engineering Lifetime Integral Explorer (FELIX) is a fusion demonstration reactor for power generation. These two concepts are considered as dominant options for future nuclear energy source from the environmental, commercial and nonproliferation points of view. XEUS may as well be applied to the fusion-fission hybrid system. The system code is being developed to analyze the steady state and transient behavior of the primary system. Compact and high efficiency heat exchangers are designed in the Loop Energy Exchanger Integral System (LEXIS). Modular Optimized Brayton Integral System (MOBIS) incorporates a Brayton cycle with supercritical fluid to achieve high power conversion ratio. The high volumetric energy density of the Brayton cycle enables designers to reduce the size and eventually the cost of the system when compared with that of the Rankine cycle. MOBIS is home to heat exchangers and turbo machineries. The advanced shell-and-tube or printed circuit heat exchanger is considered as heat transfer components to reduce size of the system. The supercritical fluid driven turbines and compressor are designed to achieve higher component efficiency. Thermo hydrodynamic characteristics of each component in MOBIS are demonstrated utilizing computational fluid dynamics software CFX R . Another key contributor to the reduction of capital costs per unit energy has to do with manufacturing and assembly processes that streamline plant construction by minimizing construction work and time. In a three

The web-enabled database of JRC-EC, a useful tool for managing European Gen IV materials data

International Nuclear Information System (INIS)

Over, H.H.; Dietz, W.

2008-01-01

Materials and document databases are important tools to conserve knowledge and experimental materials data of European R and D projects. A web-enabled application guarantees a fast access to these data. In combination with analysis tools the experimental data are used for e.g. mechanical design, construction and lifetime predictions of complex components. The effective and efficient handling of large amounts of generic and detailed materials data with regard to properties related to e.g. fabrication processes, joining techniques, irradiation or aging is one of the basic elements of data management within ongoing nuclear safety and design related European research projects and networks. The paper describes the structure and functionality of Mat-DB and gives examples how these tools can be used for the management and evaluation of materials data of European (national or multi-national) R and D activities or future reactor types such as the EURATOM FP7 Generation IV reactor types or the heavy liquid metals cooled reactor

Pré-melhoramento do camucamuzeiro: estudo de parâmetros genéticos e dissimilaridade

Directory of Open Access Journals (Sweden)

Walnice Maria Oliveira do Nascimento

2014-08-01

Full Text Available O camucamuzeiro pertence à família Myrtaceae e é espécie em processo de domesticação, encontrada na forma extrativa, a partir de plantas crescendo naturalmente nas margens dos rios e lagos, ou cultivadas em pequenas áreas de terra firme. As estimativas e a compreensão dos parâmetros genéticos desta espécie são importantes para o conhecimento da estrutura genética das populações e para a inferência da diversidade genética presente, além de proporcionar subsídios para predizer os ganhos genéticos e o possível sucesso no programa de melhoramento dessa cultura. Neste sentido, o objetivo deste trabalho foi estimar parâmetros genéticos e a dissimilaridade genética, em acessos existentes no Banco Ativo de Germoplasma de camucamuzeiro, da Embrapa Amazônia Oriental. Para o estudo, foram analisados 46 progênies, colhidos 40 frutos por planta matriz em completo estádio de maturação (frutos com epicarpo totalmente roxo, sendo avaliados sete caracteres morfoagronômicos: peso de fruto (g, PFR, comprimento de fruto (cm, CFR, diâmetro de fruto (cm, DFR, peso da casca (g, PCS, espessura da casca (cm, ECS, número de sementes (n, NSE, peso de sementes (g, PSE. Por meio do Programa Genes, estimaram-se os componentes de variância, herdabilidade e a variabilidade. A importância relativa de caracteres e dissimilaridades entre as progênies, bem como as correlações genéticas entres os caracteres avaliados também foram estudadas. Verificou-se que há dissimilaridade entre os acessos do BAG de camucamuzeiro e que, por causa das correlações significativas entre as variáveis, podem-se adotar métodos de seleção indireta como ferramenta auxiliar no processo de domesticação e melhoramento desta espécie.

Genética molecular de caracteres cuantitativos en cruzamientos dialélicos de tomate

Directory of Open Access Journals (Sweden)

Guillermo Raúl Pratta

2011-05-01

Full Text Available El objetivo de este trabajo fue evaluar marcadores moleculares y caracteres cuantitativos en un cruzamiento dialélico completo sin recíprocos, entre cinco líneas recombinantes de tomate y sus híbridos. Se obtuvieron perfiles de AFLP ("amplified fragment length polymorphism" y de polipéptidos del pericarpio en cuatro estados de madurez del fruto de 15 genotipos. Se evaluaron, entre otros: peso, acidez titulable, pH, vida poscosecha y firmeza. Se calculó el porcentaje de polimorfismo para los marcadores moleculares y el porcentaje de variabilidad genética para los caracteres cuantitativos en el grupo de líneas recombinantes, el de híbridos y el conjunto de genotipos. Se realizaron análisis de agrupamiento con cada nivel de variación genética. Para AFLP, el porcentaje de polimorfismo varió entre 34 y 54% y, para los perfiles polipeptídicos, entre 40 y 78%. Mayor polimorfismo fue observado en el grupo de híbridos. La variabilidad genética fue de 100% para acidez y 34% para firmeza, con los mayores valores en los parentales. La similitud genética varió entre los genotipos según el nivel de variación genética; pero la consistencia en el agrupamiento de algunas líneas recombinantes y sus híbridos fue conservada, lo que evidenció asociaciones entre los datos moleculares y fenotípicos.

Clasificador genérico de objetos en imágenes AVHRR

OpenAIRE

Pascual Ramírez, Fermín; Paz Pellat, Fernando; Martínez Menes, Mario; Palacios Vélez, Enrique; Mejía Sáenz, Enrique; Rubio Granados, Erasmo

2010-01-01

El presente artículo describe un algoritmo para llevar a cabo una clasificación genérica de objetos utilizando imágenes del sensor advanced very high resolution radiometer (AVHRR), basado en la firma espectral de los objetos genéricos (suelo, mezcla suelo-vegetación, cuerpos de agua, nubes, etc.). Debido a las particularidades de las bandas disponibles en el sensor AVHRR, se presenta un algoritmo específico utilizando la banda 3a (B3a) y otro utilizando la banda 3b (B3b) de este sensor. Los a...

GenBank blastn search result: AK064582 [KOME