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Sample records for gen iv service

  1. Gen IV Materials Handbook Implementation Plan

    International Nuclear Information System (INIS)

    Rittenhouse, P.; Ren, W.

    2005-01-01

    A Gen IV Materials Handbook is being developed to provide an authoritative single source of highly qualified structural materials information and materials properties data for use in design and analyses of all Generation IV Reactor Systems. The Handbook will be responsive to the needs expressed by all of the principal government, national laboratory, and private company stakeholders of Gen IV Reactor Systems. The Gen IV Materials Handbook Implementation Plan provided here addresses the purpose, rationale, attributes, and benefits of the Handbook and will detail its content, format, quality assurance, applicability, and access. Structural materials, both metallic and ceramic, for all Gen IV reactor types currently supported by the Department of Energy (DOE) will be included in the Gen IV Materials Handbook. However, initial emphasis will be on materials for the Very High Temperature Reactor (VHTR). Descriptive information (e.g., chemical composition and applicable technical specifications and codes) will be provided for each material along with an extensive presentation of mechanical and physical property data including consideration of temperature, irradiation, environment, etc. effects on properties. Access to the Gen IV Materials Handbook will be internet-based with appropriate levels of control. Information and data in the Handbook will be configured to allow search by material classes, specific materials, specific information or property class, specific property, data parameters, and individual data points identified with materials parameters, test conditions, and data source. Details on all of these as well as proposed applicability and consideration of data quality classes are provided in the Implementation Plan. Website development for the Handbook is divided into six phases including (1) detailed product analysis and specification, (2) simulation and design, (3) implementation and testing, (4) product release, (5) project/product evaluation, and (6) product

  2. Gen IV. Technical and economical aspects

    International Nuclear Information System (INIS)

    Kaluzny, Y.; Legee, F.

    2010-01-01

    In this presentation author deals with development of nuclear reactor type of Generation IV. He concluded that: - Nuclear energy is competitive with regards to the other generation sources; Its competitiveness also increases with CO 2 cost. Considering the nuclear cost breakdown of LWR reactors, it turns out that the uranium is currently not in the range of a threshold for FBR deployment; - The global balance of uranium supply and demand and also innovation required to fulfil GEN IV objectives would probably imply the emergence of fast reactor competitiveness after the turn of the mid-century; - We shall need fast reactors in the coming decade.

  3. Gen IV Materials Handbook Functionalities and Operation

    International Nuclear Information System (INIS)

    Ren, Weiju

    2009-01-01

    This document is prepared for navigation and operation of the Gen IV Materials Handbook, with architecture description and new user access initiation instructions. Development rationale and history of the Handbook is summarized. The major development aspects, architecture, and design principles of the Handbook are briefly introduced to provide an overview of its past evolution and future prospects. Detailed instructions are given with examples for navigating the constructed Handbook components and using the main functionalities. Procedures are provided in a step-by-step fashion for Data Upload Managers to upload reports and data files, as well as for new users to initiate Handbook access.

  4. Gen IV Materials Handbook Functionalities and Operation

    Energy Technology Data Exchange (ETDEWEB)

    Ren, Weiju [ORNL

    2009-12-01

    This document is prepared for navigation and operation of the Gen IV Materials Handbook, with architecture description and new user access initiation instructions. Development rationale and history of the Handbook is summarized. The major development aspects, architecture, and design principles of the Handbook are briefly introduced to provide an overview of its past evolution and future prospects. Detailed instructions are given with examples for navigating the constructed Handbook components and using the main functionalities. Procedures are provided in a step-by-step fashion for Data Upload Managers to upload reports and data files, as well as for new users to initiate Handbook access.

  5. Improvement of Steam Generator Reliability for GEN-IV SFR

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Seong O; Kim Se Yun; Kim, Seok Hoon; Eoh, Jae Hyuk; Lee, Hyeong Yeon; Choi, Byung Seon

    2005-11-15

    The R and D items performed in this study were selected from the R and D task of ' Reliability improvement of Steam Generator' of GEN-IV SFR Component Design and BOP. Since this project deals with one of the most important issues for a GEN-IV SFR system, it needs to enhance the domestic technical backgrounds associated with the corresponding R and D items even for a very short period by 2005. This study provides the R and D results for i) Development of assessment methodology for dissimilar metal weld and ii) Development of multi-dimensional simulation methodology for a SWR event in a SFR steam generator.

  6. Improvement of Steam Generator Reliability for GEN-IV SFR

    International Nuclear Information System (INIS)

    Kim, Seong O; Kim Se Yun; Kim, Seok Hoon; Eoh, Jae Hyuk; Lee, Hyeong Yeon; Choi, Byung Seon

    2005-11-01

    The R and D items performed in this study were selected from the R and D task of ' Reliability improvement of Steam Generator' of GEN-IV SFR Component Design and BOP. Since this project deals with one of the most important issues for a GEN-IV SFR system, it needs to enhance the domestic technical backgrounds associated with the corresponding R and D items even for a very short period by 2005. This study provides the R and D results for i) Development of assessment methodology for dissimilar metal weld and ii) Development of multi-dimensional simulation methodology for a SWR event in a SFR steam generator

  7. New Materials for NGNP/Gen IV

    International Nuclear Information System (INIS)

    Swindeman, Robert W.; Marriott, Douglas L.

    2009-01-01

    The bounding conditions were briefly summarized for the Next Generation Nuclear Plant (NGNP) that is the leading candidate in the Department of Energy Generation IV reactor program. Metallic materials essential to the successful development and proof of concept for the NGNP were identified. The literature bearing on the materials technology for high-temperature gas-cooled reactors was reviewed with emphasis on the needs identified for the NGNP. Several materials were identified for a more thorough study of their databases and behavioral features relative to the requirements ASME Boiler and Pressure Vessel Code, Section III, Division 1, Subsection NH.

  8. ASN’s actions in GEN IV reactors and Sodium Fast Reactors (SFR)

    International Nuclear Information System (INIS)

    Belot, Clotilde

    2013-01-01

    The ASN is involved in 3 actions concerning GEN IV: • Overview of nuclear reactor GEN IV systems; • Specific analysis about transmutation; • Prototype reactor ASTRID (SFR). Furthermore theses actions are in the beginning (no conclusions or results available)

  9. Market share scenarios for Gen-DIII and gen-IV reactors in Europe

    International Nuclear Information System (INIS)

    Roelofs, F.; Heek, A. V.; Durpel, L. V. D.

    2008-01-01

    Nuclear energy is back on the agenda worldwide in order to meet growing energy demand and especially the growth in electricity demand. Many objectives direct to an increased use of nuclear energy, i.e. minimising energy costs, reducing climate change effects and others. In the light of the potential renewed growth of nuclear energy, the public demands a clear view on what nuclear energy may contribute towards meeting these objectives and especially how nuclear energy may address some socio-political obstructions with respect to economics, radioactive waste, safety and proliferation of fissile materials. To address these questions, the future nuclear reactor park mix in Europe has been analysed applying an integrated dynamic process modelling technique. Various market share scenarios for nuclear energy are derived including sub-variants with regard to the intra-nuclear options. In the analyses, it is assumed that different types of new reactors may be built, taking into account the introduction date of considered Gen-Ill (i.e. EPR) and Gen-IV (i.e. SCWR, HTR, FR) reactors, and the economic evaluation of the complete fuel cycle. The assessment was undertaken using the DANESS code (Dynamic Analysis of Nuclear Energy System Strategies). The analyses show that given the considered realistic nuclear energy demand and given a limited number of available Gen-III and Gen-IV reactor types, the future European nuclear park will exist of combinations of Gen-III and Gen-IV reactors. This mix will always consist of a set of reactor types each having its specific strengths. The analyses also highlight the triggers influencing the choice between different nuclear energy deployment scenarios. (authors)

  10. GEN IV reactors: Where we are, where we should go

    International Nuclear Information System (INIS)

    Locatelli, G.; Mancini, M.; Todeschini, N.

    2012-01-01

    GEN IV power plants represent the mid-long term option of the nuclear sector. International literature proposes many papers and reports dealing with these reactors, but there is an evident difference of type and shape of information making impossible each kind of detailed comparison. Moreover, authors are often strongly involved in some particular design; this creates many difficulties in their super-partes position. Therefore it is necessary to put order in the most relevant information to understand strengths and weaknesses of each design and derive an overview useful for technicians and policy makers. This paper presents the state-of the art for GEN IV nuclear reactors providing a comprehensive literature review of the different designs with a relate taxonomy. It presents the more relevant references, data, advantages, disadvantages and barriers to the adoptions. In order to promote an efficient and wide adoption of GEN IV reactors the paper provides the pre-conditions that must be accomplished, enabling factors promoting the implementation and barriers limiting the extent and intensity of its implementation. It concludes outlying the state of the art of the most important R and D areas and the future achievements that must be accomplished for a wide adoption of these technologies. (authors)

  11. Reactor physics challenges in GEN-IV reactor design

    International Nuclear Information System (INIS)

    Driscoll, Michael K.; Hejzlar, Pavel

    2005-01-01

    An overview of the reactor physics aspects of GENeration Four (GEN-IV) advanced reactors is presented, emphasizing how their special requirements for enhanced sustainability, safety and economics motivates consideration of features not thoroughly analyzed in the past. The resulting concept-specific requirements for better data and methods are surveyed, and some approaches and initiatives are suggested to meet the challenges faced by the international reactor physics community. No unresolvable impediments to successful development of any of the six major types of proposed reactors are identified, given appropriate and timely devotion of resources

  12. Reactor physics challenges in GEN-IV reactor design

    Energy Technology Data Exchange (ETDEWEB)

    Driscoll, Michael K.; Hejzlar, Pavel [Massachusetts Institute of Technology, MA (United States)

    2005-02-15

    An overview of the reactor physics aspects of GENeration Four (GEN-IV) advanced reactors is presented, emphasizing how their special requirements for enhanced sustainability, safety and economics motivates consideration of features not thoroughly analyzed in the past. The resulting concept-specific requirements for better data and methods are surveyed, and some approaches and initiatives are suggested to meet the challenges faced by the international reactor physics community. No unresolvable impediments to successful development of any of the six major types of proposed reactors are identified, given appropriate and timely devotion of resources.

  13. A Virtual Reality Framework to Optimize Design, Operation and Refueling of GEN-IV Reactors

    International Nuclear Information System (INIS)

    Rizwan-uddin; Nick Karancevic; Stefano Markidis; Joel Dixon; Cheng Luo; Jared Reynolds

    2008-01-01

    Many GEN-IV candidate designs are currently under investigation. Technical issues related to material, safety and economics are being addressed at research laboratories, industry and in academia. After safety, economic feasibility is likely to be the most important criterion in the success of GEN-IV design(s). Lessons learned from the designers and operators of GEN-II (and GEN-III) reactors must play a vital role in achieving both safety and economic feasibility goals

  14. A Virtual Reality Framework to Optimize Design, Operation and Refueling of GEN-IV Reactors.

    Energy Technology Data Exchange (ETDEWEB)

    Rizwan-uddin; Nick Karancevic; Stefano Markidis; Joel Dixon; Cheng Luo; Jared Reynolds

    2008-04-23

    many GEN-IV candidate designs are currently under investigation. Technical issues related to material, safety and economics are being addressed at research laboratories, industry and in academia. After safety, economic feasibility is likely to be the most important crterion in the success of GEN-IV design(s). Lessons learned from the designers and operators of GEN-II (and GEN-III) reactors must play a vital role in achieving both safety and economic feasibility goals.

  15. JRC-IE's research of safety of Gen IV systems

    International Nuclear Information System (INIS)

    Tsige-Tamirat, H.; Ranguelova, V.; Feutterer, M.; Ammirabile, L.; Carlsson, J.; D'Agata, E.; Laurie, M.; Magallon, D.

    2010-01-01

    The Institute for Energy (IE), one of the seven scientific Institutes of the Joint Research Centre (JRC) of the European Commission, has the mission to provide scientific and technical support for the conception, development, implementation and monitoring of community policies related to energy. To accomplish its mission, IE performs research in the areas of renewable energies, safety and sustainability of nuclear energy for current and future reactor systems, energy technic/economic assessment, and security of energy supply. The Generation IV International Forum (GIF) is a cooperative international endeavour organized to carry out R and D needed to establish the feasibility and performance capabilities of the next generation nuclear energy systems and support the progress towards their realization. The EU, represented by EURATOM and with the JRC as implementing agent, is working together with other GIF partners to perform pre-competitive R and D on key technologies to be implemented in future nuclear systems. IE is engaged in experimental research, simulation and modeling, scientific, feasibility and engineering studies on innovative nuclear reactor systems needed to support the EURATOM contribution to GEN IV initiative, in particular in assessment of innovative fuels and materials, development of new reactor core concepts and safety solutions and knowledge management and preservation. IE's research activities on Generation IV reactor systems are focused on the assessment of the potential of such systems to meet long term EU energy needs with respect to economical advantages, enhanced safety, sustainability, and proliferation resistance. IE participates in international collaborations and has bilateral research cooperation both with European and non-European partners. This paper gives an overview of IE's current research activities on the Gen IV reactor systems related to safety. (authors)

  16. Developing new nuclear curricula for GEN IV needs

    International Nuclear Information System (INIS)

    Ghitescu, P.; Pavel, G.L.

    2014-01-01

    States who wish to start and develop a nuclear program must take into consideration a strong proven strategy for developing a sustainable program. A complete nuclear research program must include: a good national strategy and support on the topic; strong research laboratories supported by good personnel; education component to provide sustainable and qualified workforce; national/international interest from stakeholders and governments and a well informed society. New demonstrators are foreseen for the next period to be built in Europe and skilled supporting personnel is strongly needed. Current situation in nuclear higher education with perspective will be analysed. EURATOM strongly supports development of multidisciplinary co-operational projects in order to built such novel initiatives. An example of such program supported by European Commission, ARCADIA, will be given. The project is based on the cooperation of a large number of participants all over Europe and the main purpose is to develop a road-map for Gen IV reactor. (authors)

  17. Development of Basic Key Technologies for Gen IV SFR

    International Nuclear Information System (INIS)

    Han, Do Hee; Kim, Young In; Won, Byung Chool

    2008-11-01

    Technical specifications such as power capacity, type of core, clad alloy, clad barrier material, number of loops, type of SG tube have been evaluated and a optimal design concept has been identified to satisfy the technology goals of Generation IV nuclear systems. The concept for breakeven design is featured by the heat capacity of 1,200 MWe, enrichment-separated core, 2-loop, double-walled SG tube, and a long-life sensor system for in-service inspection

  18. Environmental sensitivity studies for Gen-IV roadmap DUPIC scenario

    International Nuclear Information System (INIS)

    Jeong, Chang Joon

    2004-03-01

    The environmental effect of the DUPIC (Direct Use of Spent PWR Fuel in CANDU Reactors) fuel cycle, which is considered as one of the partial recycle scenario in Gen-IV roadmap, has been analyzed by using the dynamic analysis method. Through the parametric calculations for the DUPIC fuel cycle deployment time and the fraction of the DUPIC reactors, the environmental effects of the fuel cycle for important parameters such as the amount of spent fuel and the combined amounts of plutonium and minor actinides were estimated and compared to those of the once-through LWR fuel cycle. The results of the sensitivity calculations showed that an early deployment of the DUPIC fuel cycle with a high DUPIC reactor fraction can reduce the accumulation of spent fuel by up to 40%. More important is the associated reduction in the combined amount of plutonium and minor actinides, which may reduce the key repository parameter (long term decay heat). Therefore it is expected that favorable environmental effects will be the outcome of the implementation of the DUPIC fuel cycle

  19. Structural materials for Gen-IV nuclear reactors: Challenges and opportunities

    Science.gov (United States)

    Murty, K. L.; Charit, I.

    2008-12-01

    Generation-IV reactor design concepts envisioned thus far cater toward a common goal of providing safer, longer lasting, proliferation-resistant and economically viable nuclear power plants. The foremost consideration in the successful development and deployment of Gen-IV reactor systems is the performance and reliability issues involving structural materials for both in-core and out-of-core applications. The structural materials need to endure much higher temperatures, higher neutron doses and extremely corrosive environment, which are beyond the experience of the current nuclear power plants. Materials under active consideration for use in different reactor components include various ferritic/martensitic steels, austenitic stainless steels, nickel-base superalloys, ceramics, composites, etc. This paper presents a summary of various Gen-IV reactor concepts, with emphasis on the structural materials issues depending on the specific application areas. This paper also discusses the challenges involved in using the existing materials under both service and off-normal conditions. Tasks become increasingly complex due to the operation of various fundamental phenomena like radiation-induced segregation, radiation-enhanced diffusion, precipitation, interactions between impurity elements and radiation-produced defects, swelling, helium generation and so forth. Further, high temperature capability (e.g. creep properties) of these materials is a critical, performance-limiting factor. It is demonstrated that novel alloy and microstructural design approaches coupled with new materials processing and fabrication techniques may mitigate the challenges, and the optimum system performance may be achieved under much demanding conditions.

  20. Safety Design Criteria (SDC) for Gen-IV Sodium-cooled Fast Reactor

    International Nuclear Information System (INIS)

    Nakai, Ryodai

    2013-01-01

    SDC Development Background & Objectives: • Safety Design Criteria (SDC) Development for Gen-IV SFR: – Proposed at the GIF Policy Group (PG) meeting in October 2010 –SDC “harmonization” is increasingly important for: • Realization of enhanced safety designs meeting to Gen-IV safety goals and safety approach common to SFR systems; • Preparation for the forthcoming licensing in the near future; • Because Gen-IV SFR are progressing into conceptual design stage. • The SDC is the Reference criteria: – Of the designs of safety-related Structures, Systems & Components that are specific to the SFR system; – For clarifying the requisites systematically & comprehensively; – When the technology developers apply the basic safety approach and use the codes & standards for conceptual design of the Gen-IV SFR system

  1. European project SARGEN IV: safety approach and assessment of GEN IV reactors

    International Nuclear Information System (INIS)

    Ammirabile, L.

    2013-01-01

    • SARGEN I V has elaborated a proposal for the harmonization of safety assessment practices for GEN IV NPP. • An overall reinforcement of DiD is expected for GEN I V NPP, including improved independence between all levels of DiD. • An inherent approach should reinforce the fulfillment of fundamental safety functions e.g. the consequences for some situations should be reduced and the grace periods should be extended. For the same reason, the use of passive systems can be envisaged. • The need of complementary and integrated deterministic and probabilistic approaches is reiterated. • Methodologies: Some of them are not yet applied. • Assessment of hazards would be a challenging aspect of next generation of NPP safety assessment and should be improved, which is confirmed by the first insights of Fukushima Daiichi TEPCO reactors accidents. • Provisions to cope with extreme events notably to improve the grace period before cliff-edge effects and thus allowing back-up measures to be implemented have to be defined and should be considered as hardened equipments

  2. Gen IV International Forum - GIF, 2010 Annual Report

    International Nuclear Information System (INIS)

    Anon.

    2011-01-01

    The Generation IV International Forum (GIF), created in 2000 to foster international collaboration at a detailed level of actual R and D, is a cooperative international endeavor, organized to develop the research necessary to test the feasibility and performance capabilities of fourth generation nuclear systems, with the goal of making such systems deployable in large numbers around 2030. Since its beginning, GIF members stated the following goals for the fourth generation of nuclear power plants when compared to previous generations: a) improve sustainability (including effective fuel utilization and minimization of waste); b) improve economics (competitiveness with respect to other energy sources); c) improve safety and reliability (e.g. no need for offsite emergency response); and d) improve proliferation resistance and physical protection. After an in-depth analysis of the different available concepts, whatever their level of development, the Forum selected six concepts as the most promising, and decided to focus R and D on these systems: - the very-high-temperature reactor (VHTR); - the sodium-cooled fast reactor (SFR); - the supercritical-water-cooled reactor (SCWR); - the gas-cooled fast reactor (GFR); - the lead-cooled fast reactor (LFR); - the molten salt reactor (MSR). Active members of the GIF are Canada, Euratom, France, Japan, People's Republic of China, Republic of Korea, Republic of South Africa, Russian Federation, Switzerland and the United States. Altogether, they represent around 90% of the world installed nuclear capacity for producing electricity, and all key technology holders. The forum is led by the policy group, where all members are represented, and currently chaired by Japan since December 2009, assisted by vice-chairs from France and United States. The year 2010 has seen some important achievements and decisions regarding these six systems. For example, two sodium-cooled fast reactors (re)started this year: Monju in Japan restarted after

  3. GIF (Gen-IV International Forum) Symposium 2009. Proceedings

    International Nuclear Information System (INIS)

    2009-01-01

    The objective of this symposium is to give a well documented state of the art of the initiative and to report and discuss the most significant technical progress and evolution in the different areas during these last ten years. Another significant objective is to provide a forum for an open and hopefully lively discussion of the perspectives, priorities and challenges for the next few years, accounting for a rapidly evolving environment. The symposium has been organized into three sessions that have dealt with the following issues: -) Generation IV International Forum (GIF): 10 years of achievements and the path forward, -) Methodology Overviews and Focus on Applications, -) Very High Temperature Reactor (VHTR), -) Gas-cooled Fast Reactor (GFR), -) Super-Critical Water-cooled Reactor (SCWR), -) Lead-cooled Fast Reactor (LFR), -) Molten Salt Reactor (MSR), -) Sodium-cooled Fast Reactor (SFR), -) International Project on Innovative Nuclear Reactors and Fuel Cycles (INPRO) and its potential synergy with GIF, and -) GIF priority objectives for the next 5 years

  4. Development of basic key technologies for Gen IV SFR

    International Nuclear Information System (INIS)

    Kim, Yeongil; Kim, Sungoh; Choi, Sukgi

    2012-04-01

    The advanced concepts, for the breakeven reactor(1,200MWe) and TRU burner(600MWe), were defined to satisfy the technology goals of Generation IV nuclear systems. Based on the advanced design concepts, a conceptual design of the demonstration SFR has been developed using the available licensing technology. The conceptual core design has been developed for the TRU burner in which an initial core is fueled with less than 20wt% enriched U235, and finally transformed to a self-recycled TRU core. The passive decay heat removal circuit ensuring reactor safety even in case of loss of emergency power has been developed and minimization of a reactor vessel and simplification of reactor internals have been conducted in the conceptual design. For development of advanced technologies, control logics for various power levels and the optimal design concept of heat exchanger applicable to supercritical CO 2 Brayton cycle as an energy conversion system was developed. A novel under-sodium waveguide sensor and a prototype under-sodium inspection system have been developed for under-sodium viewing of in-vessel structures submerged in an opaque liquid sodium. The fabrication technology of fuel slugs using the advanced fuel slug casting system was developed, and U-Zr alloy fuel rods were fabricated and examined. And a HT 9 cladding tube was manufactured using the developed cladding tube fabrication technology. For development of basic technologies, the cross section adjustment code ATCROSS and the MATRA-LMR code with HCFs have been developed to reduce core design uncertainties. The SIE ASME-NH computer program to evaluate high temperature structural design for 60 years design life, and the safety analysis code MARS-LMR with thermal-hydraulic and reactivity feedback models have been developed and validated. In addition, the sodium impurity measurement and control technology, the sodium water reaction event propagation model to predict the sodium leak propagation in a steam generator, and

  5. Safeguards Licensing Aspects of a Future Gen IV Test Facility - a Case Study

    International Nuclear Information System (INIS)

    Lindell, M. Aberg; Grape, S.; Hakansson, A.; Svaerd, S. Jacobsson

    2010-01-01

    The scope of this study covers safeguards licensing aspects of a possible future Gen IV demonstration facility. As a basis for the investigation, the facility was assumed to be located in Sweden, comprising a lead-cooled fast reactor and a reprocessing plant with fuel fabrication. The aim has been to identify safeguards requirements that may be set by the IAEA and the Swedish Radiation Safety Authority, and also to suggest how the safeguards system could be implemented in practice. The changed usage and handling of nuclear fuel, as compared to that of today, has been examined in order to determine how today's safeguards measures can be modified and extended to meet the needs of the demonstration facility. This work is part of GENIUS, the Swedish Gen IV research and development programme, which emphasizes lead-cooled fast reactors. (author)

  6. Thermal stability study for candidate stainless steels of GEN IV reactors

    International Nuclear Information System (INIS)

    Simeg Veternikova, J.; Degmova, J.; Pekarcikova, M.; Simko, F.; Petriska, M.; Skarba, M.; Mikula, P.; Pupala, M.

    2016-01-01

    Highlights: • Thermal resistance of advanced stainless steels were observed at 1000 °C. • GEN IV candidate steels were confronted to classic AISI steels. • ODS AISI 316 has weaker thermal resistance than classic AISI steel. • Ferritic ODS steels and NF 709 has better thermal resistance than AISI steels. - Abstract: Candidate stainless steels for GEN IV reactors were investigated in term of thermal and corrosion stability at high temperatures. New austenitic steel (NF 709), austenitic ODS steel (ODS 316) and two ferritic ODS steels (MA 956 and MA 957) were exposed to around 1000 °C in inert argon atmosphere at pressure of ∼8 MPa. The steels were further studied in a light of vacancy defects presence by positron annihilation spectroscopy and their thermal resistance was confronted to classic AISI steels. The thermal strain supported a creation of oxide layers observed by scanning electron microscopy (SEM).

  7. Thermal stability study for candidate stainless steels of GEN IV reactors

    Energy Technology Data Exchange (ETDEWEB)

    Simeg Veternikova, J., E-mail: jana.veternikova@stuba.sk [Institute of Nuclear and Physical Engineering, Faculty of Electrical and Information Technology, Slovak University of Technology, Ilkovicova 3, 812 19 Bratislava (Slovakia); Degmova, J. [Institute of Nuclear and Physical Engineering, Faculty of Electrical and Information Technology, Slovak University of Technology, Ilkovicova 3, 812 19 Bratislava (Slovakia); Pekarcikova, M. [Institute of Materials Science, Faculty of Materials Science and Technology, Slovak University of Technology, Paulinska 16, 917 24 Trnava (Slovakia); Simko, F. [Department of Molten Salts, Institute of Inorganic Chemistry, Slovak Academy of Sciences, Dubravska cesta 9, 845 36 Bratislava (Slovakia); Petriska, M. [Institute of Nuclear and Physical Engineering, Faculty of Electrical and Information Technology, Slovak University of Technology, Ilkovicova 3, 812 19 Bratislava (Slovakia); Skarba, M. [Slovak University of Technology, Vazovova 5, 812 43 Bratislava (Slovakia); Mikula, P. [Institute of Nuclear and Physical Engineering, Faculty of Electrical and Information Technology, Slovak University of Technology, Ilkovicova 3, 812 19 Bratislava (Slovakia); Pupala, M. [Department of Molten Salts, Institute of Inorganic Chemistry, Slovak Academy of Sciences, Dubravska cesta 9, 845 36 Bratislava (Slovakia)

    2016-11-30

    Highlights: • Thermal resistance of advanced stainless steels were observed at 1000 °C. • GEN IV candidate steels were confronted to classic AISI steels. • ODS AISI 316 has weaker thermal resistance than classic AISI steel. • Ferritic ODS steels and NF 709 has better thermal resistance than AISI steels. - Abstract: Candidate stainless steels for GEN IV reactors were investigated in term of thermal and corrosion stability at high temperatures. New austenitic steel (NF 709), austenitic ODS steel (ODS 316) and two ferritic ODS steels (MA 956 and MA 957) were exposed to around 1000 °C in inert argon atmosphere at pressure of ∼8 MPa. The steels were further studied in a light of vacancy defects presence by positron annihilation spectroscopy and their thermal resistance was confronted to classic AISI steels. The thermal strain supported a creation of oxide layers observed by scanning electron microscopy (SEM).

  8. Fuel research for subcritical and critical GEN-IV systems cooled by heavy liquid metal

    International Nuclear Information System (INIS)

    Sobolev, V.; Verwerft, M.

    2009-01-01

    The participation of the Belgian Nuclear Research Centre SCK-CEN in the worldwide GEN-IV research can be considered as an opportunity. Today's GEN-IV research at SCK-CEN is mainly driven by the interests of the project MYRRHA (Multipurpose hYbrid Research Reactor for High-tech Applications). The main goal of this project is to build at SCK-CEN in Mol a new generation fast spectrum, subcritical, research and materials testing reactor MYRRHA driven by a high-energy proton accelerator. This GEN-IV MTR is cooled by heavy liquid metal (Pb-Bi) and will be used for the ADS concept demonstration, testing and qualification of new fuels, transmutation targets and innovative materials. On the European scale, MYRRHA is integrated in the Euratom FP6 Integrated Project (IP) EUROTRANS (EUROpean research programme for TRANSmutation of high level nuclear waste in an accelerator driven system), as the small-scale experimental machine for transmutation demonstration called XT-ADS. Last but not least, this experimental facility will also demonstrate the technological feasibility of the LFR (Lead-cooled Fast Reactor) GEN-IV concept; in EU the LFR design studies are performed in the framework of the Euratom FP6 ELSY (European Lead-cooled SYstem) project, where SCK-CEN is a partner. Among the research needed to ensure a safe and reliable operation of the MYRRHA/XT ADS reactor, the development and qualification of fuel and cladding materials have been recognized as one of the main key issues to be addressed

  9. Gen IV Materials Handbook Functionalities and Operation (2B) Handbook Version 2.0

    International Nuclear Information System (INIS)

    Ren, Weiju

    2011-01-01

    This document is prepared for navigation and operation of the Gen IV Materials Handbook, with architecture description and new user access initiation instructions. Development rationale and history of the Handbook is summarized. The major development aspects, architecture, and design principles of the Handbook are briefly introduced to provide an overview of its past evolution and future prospects. Detailed instructions are given with examples for navigating the constructed Handbook components and using the main functionalities. Procedures are provided in a step-by-step fashion for Data Upload Managers to upload reports and data files, as well as for new users to initiate Handbook access.

  10. Gen IV Materials Handbook Functionalities and Operation (4A) Handbook Version 4.0

    Energy Technology Data Exchange (ETDEWEB)

    Ren, Weiju [ORNL

    2013-09-01

    This document is prepared for navigation and operation of the Gen IV Materials Handbook, with architecture description and new user access initiation instructions. Development rationale and history of the Handbook is summarized. The major development aspects, architecture, and design principles of the Handbook are briefly introduced to provide an overview of its past evolution and future prospects. Detailed instructions are given with examples for navigating the constructed Handbook components and using the main functionalities. Procedures are provided in a step-by-step fashion for Data Upload Managers to upload reports and data files, as well as for new users to initiate Handbook access.

  11. Gen IV Materials Handbook Functionalities and Operation (2B) Handbook Version 2.0

    Energy Technology Data Exchange (ETDEWEB)

    Ren, Weiju [ORNL

    2011-08-01

    This document is prepared for navigation and operation of the Gen IV Materials Handbook, with architecture description and new user access initiation instructions. Development rationale and history of the Handbook is summarized. The major development aspects, architecture, and design principles of the Handbook are briefly introduced to provide an overview of its past evolution and future prospects. Detailed instructions are given with examples for navigating the constructed Handbook components and using the main functionalities. Procedures are provided in a step-by-step fashion for Data Upload Managers to upload reports and data files, as well as for new users to initiate Handbook access.

  12. The status of proliferation resistance evaluation methodology development in GEN IV international forum

    International Nuclear Information System (INIS)

    Inoue, Naoko; Kawakubo, Yoko; Seya, Michio; Suzuki, Mitsutoshi; Kuno, Yusuke; Senzaki, Masao

    2010-01-01

    The Generation IV Nuclear Energy Systems International Forum (GIF) Proliferation Resistance and Physical Protection Working Group (PR and PP WG) was established in December 2002 in order to develop the PR and PP evaluation methodology for GEN IV nuclear energy systems. The methodology has been studied and established by international consensus. The PR and PP WG activities include development of the measures and metrics; establishment of the framework of PR and PP evaluation, the demonstration study using Example Sodium Fast Reactor (ESFR), which included the development of three evaluation approaches; the Case Study using ESFR and four kinds of threat scenarios; the joint study with GIF System Steering Committees (SSCs) of the six reactor design concepts; and the harmonization study with the IAEA's International Project on Innovative Nuclear Reactors and Fuel Cycles (INPRO). This paper reviews the status of GIF PR and PP studies and identifies the challenges and directions for applying the methodology to evaluate future nuclear energy systems in Japan. (author)

  13. Study on high temperature design methodology of heat-resistant materials for GEN-IV systems

    Energy Technology Data Exchange (ETDEWEB)

    Ryu, Woo Seog; Kim, D. W.; Kim, S. H.; Kim, W. G.; Kim, J. H.; Park, D. G.; Yoon, J. H.; Lee, H. Y.; Hing, J. H

    2005-08-15

    Analysis of the existing high temperature design and assessment codes such as US(ASME-NH,Draft Code Case for Alloy 617), France(RCC-MR), UK(R5), Japan(BDS/DDS/FDS) for Gen IV reactor structure has been carried out. In addition the scope and fields for research and development is needed in the future have been defined. For assessing the high temperature creep cracks, time dependent fracture mechanics (TDFM) parameters of the C and Ct were analyzed. The creep propagation data were obtained from the creep crack growth tests for type 316LN stainless steels, and creep crack growth testing machine for Gen-IV system up to 950 .deg. C was set up. Damage mechanism and causes for creep-fatigue were investigated. The difference between prediction creep-fatigue life and experimental life were investigated. Material properties for analysis creep-fatigue damage were recommended. The assessment procedure (Draft) on creep-fatigue crack initiation has been developed based on the technical appendix A16 of French RCC-MR code. Ultrasonic wave signal against creep ruptured specimens of type 316LN stainless steel was obtained. It was identified that creep damage can be evaluated by ultrasonic method. The NDT techniques evaluated include Barkhausen noise, magnetic hysteresis parameters, positron annihilation, X-ray diffraction and small angle neutron scattering. Experimental procedure and evaluation method of material integrity were developed through the fracture toughness test of Cr-Mo steel.

  14. Overview of Generation IV (Gen IV) Reactor Designs - Safety and Radiological Protection Considerations

    International Nuclear Information System (INIS)

    Baudrand, Olivier; Blanc, Daniel; Ivanov, Evgeny; Bonneville, Herve; Clement, Bernard; Kissane, Martin; Meignen, Renaud; Monhardt, Daniel; Nicaise, Gregory; Bourgois, Thierry; Bruna, Giovanni; Hache, Georges; Repussard, Jacques

    2012-01-01

    The purpose of this document is to provide an updated overview of specific safety and radiological protection issues for all the reactor concepts adopted by the GIF (Generation IV International Forum), independent of their advantages or disadvantages in terms of resource optimization or long-lived-waste reduction. In particular, this new document attempts to bring out the advantages and disadvantages of each concept in terms of safety, taking into account the Western European Nuclear Regulators' Association (WENRA) statement concerning safety objectives for new nuclear power plants. Using an identical framework for each reactor concept (sodium-cooled fast reactors or SFR, high / very-high temperature helium-cooled reactors of V/HTR, gas-cooled fast reactors or GFR, lead-or lead / bismuth-cooled fast reactors or LFR, molten salt reactors or MSR, and supercritical-water-cooled reactors or SCWR), this summary report provides some general conclusions regarding their safety and radiological protection issues, inspired by WENRA's safety objectives and on the basis of available information. Initial lessons drawn from the events at the Fukushima-Daiichi nuclear power plant in March 2011 have also been taken into account in IRSN's analysis of each reactor concept

  15. Decay Heat Removal in GEN IV Gas-Cooled Fast Reactors

    International Nuclear Information System (INIS)

    Lap-Yan, C.; Wie, T. Y. C.

    2009-01-01

    The safety goal of the current designs of advanced high-temperature thermal gas-cooled reactors (HTRs) is that no core meltdown would occur in a depressurization event with a combination of concurrent safety system failures. This study focused on the analysis of passive decay heat removal (DHR) in a GEN IV direct-cycle gas-cooled fast reactor (GFR) which is based on the technology developments of the HTRs. Given the different criteria and design characteristics of the GFR, an approach different from that taken for the HTRs for passive DHR would have to be explored. Different design options based on maintaining core flow were evaluated by performing transient analysis of a depressurization accident using the system code RELAP5-3D. The study also reviewed the conceptual design of autonomous systems for shutdown decay heat removal and recommends that future work in this area should be focused on the potential for Brayton cycle DHRs.

  16. Overall system description and safety characteristics of Prototype Gen IV Sodium Cooled Fast Reactor in Korea

    International Nuclear Information System (INIS)

    Yoo, Jae Woon; Chang, Jin Wook; Lim, Jae Yong; Cheon, Jin Sik; Lee, Tae Ho; Kim, Sung Kyun; Lee, Kwi Lim; Joo, Hyung Kook

    2016-01-01

    The Prototype Gen IV sodium cooled fast reactor (PGSFR) has been developed for the last 4 years, fulfilling the technology demonstration of the burning capability of transuranic elements included in light water reactor spent nuclear fuel. The PGSFR design has been focused on the robustness of safety systems by enhancing inherent safety characteristics of metal fuel and strengthening passive safety features using natural circulation and thermal expansion. The preliminary safety information document as a major outcome of the first design phase of PGSFR development was issued at the end of 2015. The project entered the second design phase at the beginning of 2016. This paper summarizes the overall structures, systems, and components of nuclear steam supply system and safety characteristics of the PGSFR. The research and development activities to demonstrate the safety performance are also briefly introduced in the paper

  17. Overall System Description and Safety Characteristics of Prototype Gen IV Sodium Cooled Fast Reactor in Korea

    Directory of Open Access Journals (Sweden)

    Jaewoon Yoo

    2016-10-01

    Full Text Available The Prototype Gen IV sodium cooled fast reactor (PGSFR has been developed for the last 4 years, fulfilling the technology demonstration of the burning capability of transuranic elements included in light water reactor spent nuclear fuel. The PGSFR design has been focused on the robustness of safety systems by enhancing inherent safety characteristics of metal fuel and strengthening passive safety features using natural circulation and thermal expansion. The preliminary safety information document as a major outcome of the first design phase of PGSFR development was issued at the end of 2015. The project entered the second design phase at the beginning of 2016. This paper summarizes the overall structures, systems, and components of nuclear steam supply system and safety characteristics of the PGSFR. The research and development activities to demonstrate the safety performance are also briefly introduced in the paper.

  18. Environmental sensitivity studies for Gen-IV roadmap fast reactor scenario

    International Nuclear Information System (INIS)

    Jeong, Chang Joon

    2004-03-01

    The environmental effect of the self-sufficient fast reactor scenario, which is considered as one of the full fissile plutonium and transuranic recycle scenario in Gen-IV roadmap, has been analyzed by using the dynamic analysis method. Through the parametric calculations for the fast reactor deployment time and capacity, the environmental effects of the fuel cycle for important parameters such as the amount of spent fuel and the combined amounts of plutonium and minor actinides were estimated and compared to those of the once-through LWR fuel cycle. The results of the sensitivity calculations showed that an early deployment of the fast reactor with a high capacity can reduce the accumulation of spent fuel by up to 37%. Furthermore, the recycling of plutonium and minor actinides can reduce the key repository parameter (long term decay heat). Therefore the favorable environmental effects can be expected with the implementation of the symbiotic fast reactor scenario

  19. A preliminary safety analysis for the prototype Gen IV Sodium-Cooled Fast Reactor

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Kwi Lim; Ha, Kwi Seok; Jeong, Jae Ho; Choi, Chi Woong; Jeong, Tae Kyeong; Ahn, Sang June; Lee, Seung Won; Chang, Won Pyo; Kang, Seok Hun; Yoo, Jae Woon [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2016-10-15

    Korea Atomic Energy Research Institute has been developing a pool-type sodium-cooled fast reactor of the Prototype Gen-IV Sodium-cooled Fast Reactor (PGSFR). To assess the effectiveness of the inherent safety features of the PGSFR, the system transients during design basis accidents and design extended conditions are analyzed with MARS-LMR and the subchannel blockage events are analyzed with MATRA-LMR-FB. In addition, the in-vessel source term is calculated based on the super-safe, small, and simple reactor methodology. The results show that the PGSFR meets safety acceptance criteria with a sufficient margin during the events and keeps accidents from deteriorating into more severe accidents.

  20. Overview of nuclear safety activities performed by JRC-IE on Gen IV fast reactor concepts

    Energy Technology Data Exchange (ETDEWEB)

    Tsige-Tamirat, H.; Ammirabile, L.; D' Agata, E.; Fuetterer, M.; Ranguelova, V. [European Commission, Joint Research Centre, Institute for Energy, Westerduinweg 3, 1755LE Petten (Netherlands)

    2010-07-01

    The European Strategic Energy Technology (SET) Plan recognizes the need to develop new energy technologies, in order to reduce greenhouse gas emissions and secure energy supply in Europe. Besides renewable energy and improved energy efficiency, a new generation of nuclear power plants and innovative nuclear power applications can play a significant role to achieve this goal. The JRC Institute for Energy 'Safety of Future Nuclear Reactors' (SFNR) Unit is engaged in experimental research, numerical simulation and modelling, scientific, feasibility and engineering studies on innovative nuclear reactor systems. This also represents a significant EURATOM contribution to the Generation IV International Forum. Its activities deal with, among others, the performance assessment of innovative fuels and materials, development of new reactor core concepts and safety solutions, and knowledge management and preservation. Special attention is given to fast reactor concepts, namely the sodium (SFR) and lead (LFR) cooled reactors. Recognizing the maturity of the SFR technology, the European Sustainable Nuclear Energy Technology Platform (SNETP) considers a prototype SFR to be built as a next-step towards the deployment of a first-of-a-kind Gen IV SFR. This paper gives an overview of current research preformed at JRC-IE with emphasis on the work performed in the Collaborative Project on European Sodium Fast Reactor (CP-ESFR) within the European Commission's Seventh Framework Program. (authors)

  1. Overview of nuclear safety activities performed by JRC-IE on Gen IV fast reactor concepts

    International Nuclear Information System (INIS)

    Tsige-Tamirat, H.; Ammirabile, L.; D'Agata, E.; Fuetterer, M.; Ranguelova, V.

    2010-01-01

    The European Strategic Energy Technology (SET) Plan recognizes the need to develop new energy technologies, in order to reduce greenhouse gas emissions and secure energy supply in Europe. Besides renewable energy and improved energy efficiency, a new generation of nuclear power plants and innovative nuclear power applications can play a significant role to achieve this goal. The JRC Institute for Energy 'Safety of Future Nuclear Reactors' (SFNR) Unit is engaged in experimental research, numerical simulation and modelling, scientific, feasibility and engineering studies on innovative nuclear reactor systems. This also represents a significant EURATOM contribution to the Generation IV International Forum. Its activities deal with, among others, the performance assessment of innovative fuels and materials, development of new reactor core concepts and safety solutions, and knowledge management and preservation. Special attention is given to fast reactor concepts, namely the sodium (SFR) and lead (LFR) cooled reactors. Recognizing the maturity of the SFR technology, the European Sustainable Nuclear Energy Technology Platform (SNETP) considers a prototype SFR to be built as a next-step towards the deployment of a first-of-a-kind Gen IV SFR. This paper gives an overview of current research preformed at JRC-IE with emphasis on the work performed in the Collaborative Project on European Sodium Fast Reactor (CP-ESFR) within the European Commission's Seventh Framework Program. (authors)

  2. Mechanical Design Concept of Fuel Assembly for Prototype GEN-IV Sodium-cooled Fast Reactor

    International Nuclear Information System (INIS)

    Yoon, K. H.; Lee, C. B.

    2014-01-01

    The prototype GEN-IV sodium-cooled fast reactor (PGSFR) is an advanced fast reactor plant design that utilizes compact modular pool-type reactors sized to enable factory fabrication and an affordable prototype test for design certification at minimum cost and risk. The design concepts of the fuel assembly (FA) were introduced for a PGSFR. Unlike that for the pressurized water reactor, there is a neutron shielding concept in the FA and recycling metal fuel. The PGSFR core is a heterogeneous, uranium-10% zirconium (U-10Zr) metal alloy fuel design with 112 assemblies: 52 inner core fuel assemblies, 60 outer core fuel assemblies, 6 primary control assemblies, 3 secondary control assemblies, 90 reflector assemblies and 102 B4C shield assemblies. This configuration is shown in Fig. 1. The core is designed to produce 150 MWe with an average temperature rise of 155 .deg. C. The inlet temperature is 390 .deg. C and the bulk outlet temperature is 545 .deg. C. The core height is 900 mm and the gas plenum length is 1,250 mm. A mechanical design of a fuel assembly for a PGSFR was established. The mechanical design concepts are well realized in the design. In addition to this, the analytical and experimental works will be carries out for verifying the design soundness

  3. Mechanical Design Concept of Fuel Assembly for Prototype GEN-IV Sodium-cooled Fast Reactor

    Energy Technology Data Exchange (ETDEWEB)

    Yoon, K. H.; Lee, C. B. [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2014-10-15

    The prototype GEN-IV sodium-cooled fast reactor (PGSFR) is an advanced fast reactor plant design that utilizes compact modular pool-type reactors sized to enable factory fabrication and an affordable prototype test for design certification at minimum cost and risk. The design concepts of the fuel assembly (FA) were introduced for a PGSFR. Unlike that for the pressurized water reactor, there is a neutron shielding concept in the FA and recycling metal fuel. The PGSFR core is a heterogeneous, uranium-10% zirconium (U-10Zr) metal alloy fuel design with 112 assemblies: 52 inner core fuel assemblies, 60 outer core fuel assemblies, 6 primary control assemblies, 3 secondary control assemblies, 90 reflector assemblies and 102 B4C shield assemblies. This configuration is shown in Fig. 1. The core is designed to produce 150 MWe with an average temperature rise of 155 .deg. C. The inlet temperature is 390 .deg. C and the bulk outlet temperature is 545 .deg. C. The core height is 900 mm and the gas plenum length is 1,250 mm. A mechanical design of a fuel assembly for a PGSFR was established. The mechanical design concepts are well realized in the design. In addition to this, the analytical and experimental works will be carries out for verifying the design soundness.

  4. Summary of Structural Concept Development and High Temperature Structural Integrity Evaluation Technology for a Gen-IV SFR

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Jae Han; Joo, Young Sang; Lee, Hyeong Yeon (and others)

    2008-04-15

    The economic improvement is a hot issue as one of Gen IV nuclear plant goals. It requires many researches and development works to meet the goal by securing the same level of plant safety. One of the key research items is the increase of the plant capacity with the minimum number of components and loops. Through the successful conceptual design experience for the KALIMER-600, the structural design study for a 1200MWe large capacity of sodium-cooled fast reactor has been performed to achieve the above plant size effects. The component number and reactor structural sizing were determined based on the core and fluid system design information. Several researches were performed to reduce the construction cost of NSSS in structural point of view, for example, a simplified component arrangement, concept proposals of integrated components, a high temperature LBB application technology, and an innovative in-service inspection (ISI) tool, and a computer program development of the ASME-NH design procedure of the class 1 structure and component under high temperature over 500 .deg. C. The IHTS piping arrangement was also proposed to minimize the length through the properly locating the SG and pump by 126m. Further studies of these concepts are required to confirm on the fabricability and the structural integrity for the operating and design loads. The proposed concepts will be optimized to a unified conceptual design through several trade-off studies.

  5. Level II Probabilistic Safety Analysis Methodology for the Application to GEN-IV Sodium-cooled Fast Reactor

    International Nuclear Information System (INIS)

    Park, S. Y.; Kim, T. W.; Han, S. H.; Jeong, H. Y.

    2010-03-01

    The Korea Atomic Energy Research Institute (KAERI) has been developing liquid metal reactor (LMR) design technologies under a National Nuclear R and D Program. Nevertheless, there is no experience of the probabilistic safety assessment (PSA) domestically for a fast reactor with the metal fuel. Therefore, the objective of this study is to establish the methodologies of risk assessment for the reference design of GEN-IV sodium fast reactor (SFR). An applicability of the PSA methodology of U. S. NRC and PRISM plant to the domestic GEN-IV SFR has been studied. The study contains a plant damage state analysis, a containment event tree analysis, and a source-term release category binning process

  6. The ENEN-III project: Technical Training on the Concepts and Design of GEN IV nuclear reactors

    International Nuclear Information System (INIS)

    Berkvens, T.; Renault, C.; Alonso, M.; Salomaa, R.; Schönfelder, C.

    2013-01-01

    Some conclusions: • Not enough training courses to cover the LO’s: – Especially GEN IV; – Many introductory courses, little specific courses; – Reach out to other partners for more courses. • Skills and Attitudes: – Much more difficult to train/measure; – To be treated in a separate project. • Use of Learning Outcomes must be promoted; • Involvement of human resources necessary for the successful implementation of the schemes: – End of project workshop

  7. Development of Basic Key Technologies for Gen IV SFR Safety Evaluation

    International Nuclear Information System (INIS)

    Jeong, Hae Yong; Kwon, Young Min; Kim, Tae Woon; Park, Soo Yong; Suk, Soo Dong; Lee, Kwi Lim; Lee, Yong Bum; Chang, Won Pyo; Ha, Kwi Seok; Hahn, Sang Hoon

    2010-07-01

    Safety issues and design requirements on control rod worth were identified through the evaluation of safety design characteristics and the preliminary safety evaluation. This results will be taken into account for the conceptual design studies of the demonstration reactor in the next stage. The Level-1 Pasa has been performed and a quantitative Cdf value was produced for the selected design from the several candidates. The inherent safety characteristics of the selected design were evaluated through the DBE and ATWS analyses. A surrogate material for Tru has been selected which is applicable to the study of liquidus/solidus temperature test for the metallic fuel containing Tru. A methodology for the regression analysis with surrogate material has been developed and valuable data on metal fuel liquidus/solidus temperature have been measured. A simple mechanistic model describing a bending of subassemblies has been formulated based on the foreign test data and existing models. Its applicability has been evaluated for the Phenix design. New criteria of the core damage for the SFR PSA were identified. The list of initiating events, system response event tree, and core response event tree, which constitute a PSA methodology for an SFR, have been introduced. By developing the SFR PIRT, phenomenological model features, which have to be satisfied in a safety code, were defined and the PIRT results were applied to the design of the PDRC test facility. Bases for a safety evaluation methodology for the SFR DBEs have been also prepared. A draft version of the topical report on the code for local fault analysis has been completed. Since 2007, the MARS-LMR code has been developed and assessments for model validation with the test data from EBR-II and Phenix reactor have been continued. The code has been applied to the evaluation of passive safety of a conceptual design of Gen IV SFR

  8. The Atalante facility at CEA/Marcoule: towards Gen IV systems fuel cycle

    Energy Technology Data Exchange (ETDEWEB)

    Bordier, Gilles; Warin, Dominique; Masson, Michel [CEA/Marcoule Direction, BP 17171 - 30207 - Bagnols-sur-Ceze Cedex (France)

    2008-07-01

    The Atalante facility is a complete set of 18 hot labs and 9 shielded cells devoted to the research and development on fuel cycle. The activities correspond to 4 major sectors of nuclear research: -) to support the operation of actual reprocessing plants with the aim of adapting the head of the process to the increase of the spend fuel burn-up and to different types of new burnt fuels to be reprocessed (including MOX, USi or UMo fuels); -) to develop the COEX{sup TM} process that jointly manages uranium and plutonium from the dissolution of spent fuel to the production of UPuO{sub 2} powder and the fabrication of MOX fuel pellets; -) to prepare the recycling of minor actinides (MA) by partitioning or by grouped actinide extraction, and by MA bearing fuel fabrication; -) to study the long term behavior of high level waste conditioning matrices and especially self irradiation and leaching of vitrified waste. The first hot lab of Atalante was operated in 1992, the process shielded cell (CBP) in 2003 and the last LN1 lab in 2005, while at the same time a large scale demonstration test on the DIAMEX-SANEX MA partitioning process was performed. Now some new challenges involve further necessary evolutions of the facility. Some are related to safety assessment and operating flexibility; the major evolutions will come from new scientific goals and research programs. Furthermore, minor actinides materials irradiation tests in fast reactors will be prepared in the framework of a large international cooperation (GACID program) and need the production of significant amounts of MA bearing mixed U-Pu oxide compounds in new hot labs and shielded cells equipment. The major new research tools are presented and we highlight how Atalante is a unique facility which brings a real opportunity to reinforce the European and international scientific cooperation in order to prepare the next Gen IV fuel cycle. (authors)

  9. The Atalante facility at CEA/Marcoule: towards Gen IV systems fuel cycle

    International Nuclear Information System (INIS)

    Bordier, Gilles; Warin, Dominique; Masson, Michel

    2008-01-01

    The Atalante facility is a complete set of 18 hot labs and 9 shielded cells devoted to the research and development on fuel cycle. The activities correspond to 4 major sectors of nuclear research: -) to support the operation of actual reprocessing plants with the aim of adapting the head of the process to the increase of the spend fuel burn-up and to different types of new burnt fuels to be reprocessed (including MOX, USi or UMo fuels); -) to develop the COEX TM process that jointly manages uranium and plutonium from the dissolution of spent fuel to the production of UPuO 2 powder and the fabrication of MOX fuel pellets; -) to prepare the recycling of minor actinides (MA) by partitioning or by grouped actinide extraction, and by MA bearing fuel fabrication; -) to study the long term behavior of high level waste conditioning matrices and especially self irradiation and leaching of vitrified waste. The first hot lab of Atalante was operated in 1992, the process shielded cell (CBP) in 2003 and the last LN1 lab in 2005, while at the same time a large scale demonstration test on the DIAMEX-SANEX MA partitioning process was performed. Now some new challenges involve further necessary evolutions of the facility. Some are related to safety assessment and operating flexibility; the major evolutions will come from new scientific goals and research programs. Furthermore, minor actinides materials irradiation tests in fast reactors will be prepared in the framework of a large international cooperation (GACID program) and need the production of significant amounts of MA bearing mixed U-Pu oxide compounds in new hot labs and shielded cells equipment. The major new research tools are presented and we highlight how Atalante is a unique facility which brings a real opportunity to reinforce the European and international scientific cooperation in order to prepare the next Gen IV fuel cycle. (authors)

  10. The safety R and D for GEN-IV reactors in the European nuclear energy technology platform strategic research agenda

    International Nuclear Information System (INIS)

    Bruna, G.

    2009-01-01

    In the fall 2007 EC launched the Sustainable Nuclear Energy Technology Platform (SNE-TP). The SNE-TP governing board set-up three working groups (WG): 1) Strategic Research Agenda (SRA) WG, in charge of drafting road-maps to support research, development and demonstration for current and future NPPs; 2) Deployment Strategy (DS) WG, in charge of defining the research road-map implementation and 3) Education, Training and Knowledge management (ETKM) WG, which was aimed at issuing proposal to reinforce European education and attract young in the nuclear field. The SRA WG was mandated to prepare the SRA vision document based on the preliminary road-map sketched in the document published by the Commission earlier in 2007. The SRA WG was originally organized in 5 sub-groups covering specific topics (1) GEN II and III, III+, including Advanced LWR, 2) Advanced Fuel Cycle for waste minimization and resource optimization; 3) GEN IV Fast Systems (SFR, LFR, GFR, ADS); 4) GEN IV (V) HTR and non-electricity-production applications; 5) New Nuclear Large Research Infrastructures) and 5 other sub-groups dealing with more generic cross-cutting research activities applicable to many specific topics, namely: 1) Structural material research; 2) modeling, simulation and methods, including physical data and tools and means for qualification and validation; 3) Reactor Safety, including severe accidents and human factor; 4) Advanced Driver and Minor Actinide Fuels: science and properties; 5) Pre-normative Research, Codes and Standards.The present paper is mainly aimed at summarizing the content of the SRA Safety sub-chapter focusing on GEN-IV aspects

  11. Conceptual Design on Primary Control Rod Drive Mechanism of a Prototype Gen-IV SFR

    International Nuclear Information System (INIS)

    Lee, Jae Han; Koo, Gyeong Hoi

    2013-01-01

    This paper describes the key concept of the drive mechanism, and suggests a required motor power and reducer gears to meet the functional design requirements, and a seismic response analysis of CRDM housing is performed to check its structural integrity. An AC servo motor is selected as a CRA driving power because it uses permanent magnets and is brushless type while DC motor needs a brush and a coil rotates. The control shim motor size is constrained by a housing diameter of 250mm. The driving system has several design requirements. To calculate the motor power, the drive shaft torque is needed. One part of the drive shaft has a lead screw, driving by a ball-nut. The ball screw driver torque (Tr) is calculated by some equations as follow; A servo motor with a nominal power of 100W, a nominal torque of 0.32 N-m (max. 0.48N-m) is selected considering a safety margin. Its diameter is about 50mm. The fast drive-in motor needs a strong power to insert enforcedly the stuck CRA into core within a required time. The motor sizes are calculated by the same procedure. The diameters are in the range of 80mm to 110mm by the insertion time (10 ∼ 24 seconds). The prototype Gen-IV SFR (sodium-cooled Fast Reactor) is of 150MWe capacity. The reactor has six primary control rod assemblies(CRAs). The primary control rod is used for power control, burn-up compensation and reactor shutdown in response to demands from the plant control or protection systems. The control rod drive mechanism (CRDM) consists of the drive motor assembly, the driveline, and its housing. The driveline consists of three concentric members of a drive shaft, a tension tube, and a position indicator rod, and it connects the drive motor assembly to the CRA. Main issue is that these many driving parts shall be enclosed within a limited housing diameter because the available pitch of CRDMs is limited by 300mm

  12. Conceptual Design on Primary Control Rod Drive Mechanism of a Prototype Gen-IV SFR

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Jae Han; Koo, Gyeong Hoi [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2013-10-15

    This paper describes the key concept of the drive mechanism, and suggests a required motor power and reducer gears to meet the functional design requirements, and a seismic response analysis of CRDM housing is performed to check its structural integrity. An AC servo motor is selected as a CRA driving power because it uses permanent magnets and is brushless type while DC motor needs a brush and a coil rotates. The control shim motor size is constrained by a housing diameter of 250mm. The driving system has several design requirements. To calculate the motor power, the drive shaft torque is needed. One part of the drive shaft has a lead screw, driving by a ball-nut. The ball screw driver torque (Tr) is calculated by some equations as follow; A servo motor with a nominal power of 100W, a nominal torque of 0.32 N-m (max. 0.48N-m) is selected considering a safety margin. Its diameter is about 50mm. The fast drive-in motor needs a strong power to insert enforcedly the stuck CRA into core within a required time. The motor sizes are calculated by the same procedure. The diameters are in the range of 80mm to 110mm by the insertion time (10 ∼ 24 seconds). The prototype Gen-IV SFR (sodium-cooled Fast Reactor) is of 150MWe capacity. The reactor has six primary control rod assemblies(CRAs). The primary control rod is used for power control, burn-up compensation and reactor shutdown in response to demands from the plant control or protection systems. The control rod drive mechanism (CRDM) consists of the drive motor assembly, the driveline, and its housing. The driveline consists of three concentric members of a drive shaft, a tension tube, and a position indicator rod, and it connects the drive motor assembly to the CRA. Main issue is that these many driving parts shall be enclosed within a limited housing diameter because the available pitch of CRDMs is limited by 300mm.

  13. A Qualitative Assessment of Diversion Scenarios for a GEN IV Example Sodium Fast Reactor Using the GEN IV PR and PP Methodology

    Energy Technology Data Exchange (ETDEWEB)

    Zentner, M.D.; Coles, G.A. [PNNL, P.O. Box 999, 902 Battelle Boulvard, Richland, WA 99336 (United States); Therios, I.U. [Argonne National Lab. - ANL (United States)

    2009-06-15

    An experts working group was created in 2002 by The Generation IV International Forum for the purpose of developing an internationally accepted methodology for assessing the proliferation resistance of a nuclear energy system (NES) and its individual elements. A two year case study was performed by the working group using this methodology to assess the proliferation resistance of a hypothetical NES called the Example Sodium Fast Reactor (ESFR). This work demonstrates how the PR and PP methodology can be used to provide important information to designers at various levels of details, including pre-conceptual design stage. The study analyzes the response of the ESFR entire nuclear energy system to different proliferation and theft strategies. The challenges considered comprise concealed diversion, concealed misuse and abrogation strategies. This paper describes the work done in performing a qualitative assessment of potential concealed diversion scenarios from the ESFR, and includes an evaluation of the potential effect of changes in the conversion ratio on diversion strategies. (authors)

  14. Progress reports for Gen IV sodium fast reactor activities FY 2007

    International Nuclear Information System (INIS)

    Cahalan, J. E.; Tentner, A. M.

    2007-01-01

    for prevention of progression into severe accident conditions (prevention of core melting) or for mitigation of severe accident consequences (mitigation of the impact of core melting to protect public health and safety). Because design measures for severe accident prevention and mitigation are beyond the normal design basis, established regulatory guidelines and codes do not provide explicit identification of the design performance requirements for severe accident accommodation. The treatment of severe accidents is one of the key issues of R and D plans for the Gen IV systems in general, and for the Sodium Fast Reactor (SFR) in particular. Despite the lack of an unambiguous definition of safety approach applicable for severe accidents, there is an emerging consensus on the need for their consideration for the design. The US SFR program and Argonne National Laboratory (ANL) in particular have actively studied the potential scenarios and consequences of Hypothetical Core Disruptive Accidents (HCDA) for SFRs with oxide fuel during the Fast Flux Test Facility (FFTF) and Clinch River Breeder Reactor Plant (CRBRP) programs in the 70s and 80s. Later, the focus of the US SFR safety R and D activities shifted to the prevention of all HCDAs through passive safety features of the SFRs with metal fuel in the Integral Fast Reactor (IFR) program, and the study of severe accident consequences was de-emphasized. The goal of this paper is to provide an overview of the current SFR safety approach and the role of severe accidents in Japan and France, in preparation for an expected and more active collaboration in this area between the US, Japan, and France

  15. Conversion of actinide solutions for the production of MA bearing fuels for Gen IV fast reactor systems

    International Nuclear Information System (INIS)

    Fernandez, A.; McGinley, J.; Somers, J.

    2008-01-01

    The conversion of the solution to solid for fuels containing minor actinides for accelerator driven systems or Gen IV fast reactors cannot be made by conventional ammonia or oxalate precipitation as is the case in today's reprocessing plant. The small particle size and concomitant dust that is produced in subsequent processing steps will not permit use of these processes on industrial scale. Innovation is needed to avoid dust generating powders, and indeed to simplify the processes themselves. Two such processing routes have been developed at the JRC-ITU. The sol gel route has been used to produce fuel containing Am and Np for the SUPERFACT, TRABANT and other irradiation experiments. The infiltration process has also been established and fuels have been produced for the FUTURIX and HELIOS experiments. (authors)

  16. Conversion of actinide solutions for the production of MA bearing fuels for Gen IV fast reactor systems

    Energy Technology Data Exchange (ETDEWEB)

    Fernandez, A.; McGinley, J.; Somers, J. [European Commission, Joint Research Centre, Institute for Transuranium Elements P.O.Box 2340, Karlsruhe, D-76125 (Germany)

    2008-07-01

    The conversion of the solution to solid for fuels containing minor actinides for accelerator driven systems or Gen IV fast reactors cannot be made by conventional ammonia or oxalate precipitation as is the case in today's reprocessing plant. The small particle size and concomitant dust that is produced in subsequent processing steps will not permit use of these processes on industrial scale. Innovation is needed to avoid dust generating powders, and indeed to simplify the processes themselves. Two such processing routes have been developed at the JRC-ITU. The sol gel route has been used to produce fuel containing Am and Np for the SUPERFACT, TRABANT and other irradiation experiments. The infiltration process has also been established and fuels have been produced for the FUTURIX and HELIOS experiments. (authors)

  17. Overview of Generation IV (Gen IV) Reactor Designs - Safety and Radiological Protection Considerations. Published on September 24, 2012

    International Nuclear Information System (INIS)

    Couturier, Jean; Bruna, Giovanni; Baudrand, Olivier; Blanc, Daniel; Ivanov, Evgeny; Bonneville, Herve; Clement, Bernard; Kissane, Martin; Meignen, Renaud; Monhardt, Daniel; Nicaise, Gregory; Bourgois, Thierry; Hache, Georges

    2012-01-01

    The purpose of this document is to provide an updated overview of specific safety and radiological protection issues for all the reactor concepts adopted by the GIF (Generation IV International Forum), independent of their advantages or disadvantages in terms of resource optimization or long-lived-waste reduction. In particular, this new document attempts to bring out the advantages and disadvantages of each concept in terms of safety, taking into account the Western European Nuclear Regulators' Association (WENRA) statement concerning safety objectives for new nuclear power plants. Using an identical framework for each reactor concept (sodium-cooled fast reactors or SFR, high / very-high temperature helium-cooled reactors of V/HTR, gas-cooled fast reactors or GFR, lead-or lead / bismuth-cooled fast reactors or LFR, molten salt reactors or MSR, and supercritical-water-cooled reactors or SCWR), this summary report provides some general conclusions regarding their safety and radiological protection issues, inspired by WENRA's safety objectives and on the basis of available information. Initial lessons drawn from the events at the Fukushima-Daiichi nuclear power plant in March 2011 have also been taken into account in IRSN's analysis of each reactor concept

  18. Bolivian Rhinotragini IV: Paraeclipta gen. nov. (Coleoptera, Cerambycidae, new species and new combinations

    Directory of Open Access Journals (Sweden)

    Robin O. S. Clarke

    2011-01-01

    Full Text Available Paraeclipta gen. nov. is described to allocate five new species, and ten transferred from Eclipta Bates, 1873: P. cabrujai sp. nov.; P. clementecruzi sp. nov.; P. melgarae sp. nov.; P. tomhacketti sp. nov.; P. moscosoi sp. nov.; P. bicoloripes (Zajciw, 1965, comb. nov.; P. croceicornis (Gounelle, 1911, comb. nov.; P. flavipes (Melzer, 1922, comb. nov.; P. jejuna (Gounelle, 1911, comb. nov.; P. kawensis (Peñaherrera-Leiva & Tavakilian, 2004, comb. nov.; P. longipennis (Fisher, 1947, comb. nov.; P. rectipennis (Zajciw, 1965, comb. nov.; P. soumourouensis (Tavakilian & Peñaherrera-Leiva, 2003, comb. nov.; P. tenuis (Burmeister, 1865, comb. nov.; and P. unicoloripes (Zajciw, 1965, comb. nov. The Bolivian species are illustrated. A key to their identification and host flower records are provided.

  19. Progress in the development of the neutron flux monitoring system of the French GEN-IV SFR: simulations and experimental validations [ANIMMA--2015-IO-98

    Energy Technology Data Exchange (ETDEWEB)

    Jammes, C.; Filliatre, P.; De Izarra, G. [CEA, DEN, DER, Instrumentation, Sensors and Dosimetry Laboratory, Cadarache, F-13108 Saint-Paul-lez-Durance, (France); Elter, Zs.; Pazsit, I. [Chalmers University of Technology, Department of Applied Physics, Division of Nuclear Engineering, SE-412 96 Goteborg, (Sweden); Verma, V.; Hellesen, C.; Jacobsson, S. [Division of Applied Nuclear Physics, Uppsala University, Box 516, SE-75120 Uppsala, (Sweden); Hamrita, H.; Bakkali, M. [CEA, DRT, LIST, Sensors and Electronic Architecture Laboratory, Saclay, F-91191 Gif Sur Yvette, (France); Chapoutier, N.; Scholer, A-C.; Verrier, D. [AREVA NP, 10 rue Juliette Recamier F-69456 Lyon, (France); Cantonnet, B.; Nappe, J-C. [PHONIS France S.A.S, Nuclear Instrumentation, Avenue Roger Roncier, B.P. 520, F-19106 Brive Cedex, (France); Molinie, P.; Dessante, P.; Hanna, R.; Kirkpatrick, M.; Odic, E. [Supelec, Department of Power and Energy System, F-91192 Gif Sur Yvette, (France); Jadot, F. [CEA, DEN, DER, ASTRID Project Group, Cadarache, F-13108 Saint-Paul-lez-Durance, (France)

    2015-07-01

    The neutron flux monitoring system of the French GEN-IV sodium-cooled fast reactor will rely on high temperature fission chambers installed in the reactor vessel and capable of operating over a wide-range neutron flux. The definition of such a system is presented and the technological solutions are justified with the use of simulation and experimental results. (authors)

  20. Innovative materials for GEN IV systems and transmutation facilities (cross-cutting research project GETMAT)

    International Nuclear Information System (INIS)

    Fazio, Concetta; Rieth, Michael; Gomez Briceno, Dolores; Gessi, Alessandro; Henry, Jean; Malerba, Lorenzo

    2010-01-01

    The objectives of the 'Generation IV and Transmutation Materials' (GETMAT) project is to contribute to the development, qualification and ranking of different types of ODS steels and to qualify Ferritic/Martensitic steels in a wide irradiation condition range. The experimental approach is complemented by the development of physical models with the aim to understand and improve the predictability of the materials performance. The GETMAT consortium is composed of fourteen Research centres, nine Universities and one Utility, from eleven European countries. The R and D tasks address (i) the materials availability, fabricability, weldability and their fundamental mechanical properties, (ii) their compatibility with aggressive coolants and development of corrosion protection methods; (iii) their performance under neutron irradiation, and (iv) starting from model alloys relevant for the two classes of alloys, the development and validation of physical models. The exploitation of results to potential end-users will occur through the 'GETMAT User Group', where exchange of information with the nuclear and steel industries, international (outside Europe) Research Organisations and engineers involved in the design of the new reactors, will occur. The exploitation of results to potential end-users will occur through the G ETMAT User Group , where exchange of information with the nuclear and steel industries, international (outside Europe) Research Organisations and engineers involved in the design of the new reactors, will occur

  1. Safety design approach for JSFR toward the realization of GEN IV SFR

    International Nuclear Information System (INIS)

    Kubo, S.; Yamano, H.; Chikazawa, Y.; Shimakawa, Y.

    2013-01-01

    Conclusion: Safety Design Approach for JSFR: • Based on the safety design criteria for Generation-IV SFR • DECs, Situations practically eliminated and related design measures are identified and selected with due consideration of the safety features of SFR and the lessons learned from the TEPCO’s Fukushima Dai-ichi nuclear power plants accident Safety Design Concept of JSFR: • For failure to shutdown: Passive shutdown capability, Mitigation of core damage (Prevention of severe mechanical energy release, In-Vessel Retention) • For failure to remove heat: Prevention of significant core damage (Natural circulation DHR, Alternative cooling measures) • Containment: Prevention of sever dynamic loads by design measures (IVR, double boundary concept, inertization)

  2. A Stochastic Proof of the Resonant Scattering Kernel and its Applications for Gen IV Reactors Type

    International Nuclear Information System (INIS)

    Becker, B.; Dagan, R.; Broeders, C.H.M.; Lohnert, G.

    2008-01-01

    Monte Carlo codes such as MCNP are widely accepted as almost-reference for reactor analysis. The Monte Carlo Code should therefore use as few as possible approximations in order to produce 'experimental-level' calculations. In this study we deal with one of the most problematic approximations done in MCNP in which the resonances are ignored for the secondary neutron energy distribution, namely the change of the energy and angular direction of the neutron after interaction with a heavy isotope with pronounced resonances. The endeavour of exploiting the influence of the resonances on the scattering kernel goes back to 1944 where E. Wigner and J. Wilkins developed the first temperature dependent scattering kernel. However only in 1998, the full analytical solution for the double differential resonant dependent scattering kernel was suggested by W. Rothenstein and R. Dagan. An independent stochastic approach is presented for the first time to confirm the above analytical kernel with a complete different methodology. Moreover, by manipulating in a subtle manner the scattering subroutine COLIDN of MCNP, it is proven that this very subroutine is, to some extent, inappropriate as well as the relevant explanation in the MCNP manual. The impact of this improved resonance dependent scattering kernel on diverse types of reactors, in particular for the Generation IV innovative core design HTR, is shown to be significant. (authors)

  3. Status of the French R/D program on the severe accident issue to develop Gen IV SFRs - 15373

    International Nuclear Information System (INIS)

    Serre, F.; Bertrand, F.; Journeau, C.; Suteau, C.; Verwaede, D.; Schmitt, D.; Farges, B.

    2015-01-01

    The ASTRID reactor (Advanced Sodium Technological Reactor for Industrial Demonstration) is a technological demonstrator designed by the CEA with its industrial partners, with very high levels of requirements. In the ASTRID project, the safety objectives are to prevent core melting, in particular by the development of an innovative core with complementary safety prevention devices, and to enhance the reactor resistance to severe accident by design. To mitigate the consequences of hypothetical core melting situations, specific dispositions or mitigation devices will be added to the core and to the reactor. It is also required to provide a robust safety demonstration (with high level of confidence). Therefore a new approach for severe accident issue has been defined: to the well-known 'lines of defense' method, a 'lines of mitigation' method is added. To meet these ASTRID, or future SFR, requirements, a large R/D program was launched in the Severe Accident domain, with a large number of partners. This paper will present the status of the CEA R/D related to the SFR Severe Accident issue, the collaboration framework (with industrial partners and R/D foreign organizations), and the future R/D plans to support the ASTRID project and possible developments for future Gen IV commercial SFR. (authors)

  4. Uranium enrichment reduction in the Prototype Gen-IV sodium-cooled fast reactor (PGSFR) with PBO reflector

    Energy Technology Data Exchange (ETDEWEB)

    Hartanto, Donny; Kim, Chi Hyung; Kim, Yong Hee [Dept. of Nuclear and Quantum Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon (Korea, Republic of)

    2016-04-15

    The Korean Prototype Gen-IV sodium-cooled fast reactor (PGSFR) is supposed to be loaded with a relatively-costly low-enriched U fuel, while its envisaged transuranic fuels are not available for transmutation. In this work, the U-enrichment reduction by improving the neutron economy is pursued to save the fuel cost. To improve the neutron economy of the core, a new reflector material, PbO, has been introduced to replace the conventional HT9 reflector in the current PGSFR core. Two types of PbO reflectors are considered: one is the conventional pin-type and the other one is an inverted configuration. The inverted PbO reflector design is intended to maximize the PbO volume fraction in the reflector assembly. In addition, the core radial configuration is also modified to maximize the performance of the PbO reflector. For the baseline PGSFR core with several reflector options, the U enrichment requirement has been analyzed and the fuel depletion analysis is performed to derive the equilibrium cycle parameters. The linear reactivity model is used to determine the equilibrium cycle performances of the core. Impacts of the new PbO reflectors are characterized in terms of the cycle length, neutron leakage, radial power distribution, and operational fuel cost.

  5. Enhanced radiation resistance through interface modification of nano-structured steels for Gen IV in-core applications

    International Nuclear Information System (INIS)

    Jang, Jinsung; Kang, Suk Hoon; Kim, Min Chul

    2013-06-01

    This project is to increase radiation tolerance of candidate alloys for Gen IV core component through the optimization of grain size and grain boundary characteristics. The focus is on nanocrystalline metal alloys with a fcc crystal structure. The long-term goal is to design and develop bulk nanostructured austenitic steels with enhanced void swelling resistance and substantial ductility, and to enhance their creep resistance at elevated temperatures via grain boundary engineering. An austenitic stainless steel, HT-UPS (high temperature ultra-fine precipitates strengthened) was developed at ORNL, and is expected to show enhanced void swelling resistance through the trapping of point defects at nanometer-sized carbides. Reducing the grain size and increasing the fraction-induced point defects (due to the increased sink area of the grain boundaries), to make bubble nucleation at the boundaries less likely (by reducing the fraction of high-energy boundaries), and to improve the strength and ductility under radiation by producing a higher density of nanometer sized carbides on the boundaries

  6. Design and Selection of Innovative Primary Circulation Pumps for GEN-IV Lead Fast Reactors

    Directory of Open Access Journals (Sweden)

    Walter Borreani

    2017-12-01

    Full Text Available Although Lead-cooled Fast Reactor (LFR is not a new concept, it continues to be an example of innovation in the nuclear field. Recently, there has been strong interest in liquid lead (Pb or liquid lead–bismuth eutectic (LBE both critical and subcritical systems in a relevant number of Countries, including studies performed in the frame of GENERATION-IV initiative. In this paper, the theoretical and computational findings for three different designs of Primary Circulation Pump (PCP evolving liquid lead (namely the jet pump, the Archimedean pump and the blade pump are presented with reference to the ALFRED (Advanced Lead Fast Reactor European Demonstrator design. The pumps are first analyzed from the theoretical point of view and then modeled with a 3D CFD code. Required design performance of the pumps are approximatively around an effective head of 2 bar with a mass flow rate of 5000 kg/s. Taking into account the geometrical constraints of the reactor and the fluid dynamics characteristics of the molten lead, the maximum design velocity for molten lead fluid flow of 2 m/s may be exceeded giving rise to unacceptable erosion phenomena of the blade or rotating component of the primary pumping system. For this reason a deep investigation of non-conventional axial pumps has been performed. The results presented shows that the design of the jet pump looks like beyond the current technological feasibility while, once the mechanical challenges of the Archimedean (screw pump and the fluid-dynamic issues of the blade pump will be addressed, both could represent viable solutions as PCP for ALFRED. Particularly, the blade pump shows the best performance in terms of pressure head generated in normal operation conditions as well as pressure drop in locked rotor conditions. Further optimizations (mainly for what the geometrical configuration is concerned are still necessary.

  7. Status of the Gen-IV Proliferation Resistance and Physical Protection (PRPP) Evaluation Methodology

    International Nuclear Information System (INIS)

    Whitlock, J.; Bari, R.; Peterson, P.; Padoani, F.; Cojazzi, G.G.M.; Renda, G.; ); Cazalet, J.; Haas, E.; Hori, K.; Kawakubo, Y.; Chang, S.; Kim, H.; Kwon, E.-H.; Yoo, H.; Chebeskov, A.; Pshakin, G.; Pilat, J.F.; Therios, I.; Bertel, E.

    2015-01-01

    Methodologies have been developed within the Generation IV International Forum (GIF) to support the assessment and improvement of system performance in the areas safeguards, security, economics and safety. Of these four areas, safeguards and security are the subjects of the GIF working group on Proliferation Resistance and Physical Protection (PRPP). Since the PRPP methodology (now at Revision 6) represents a mature, generic, and comprehensive evaluation approach, and is freely available on the GIF public website, several non-GIF technical groups have chosen to utilize the PRPP methodology for their own goals. Indeed, the results of the evaluations performed with the methodology are intended for three types of generic users: system designers, programme policy makers, and external stakeholders. The PRPP Working Group developed the methodology through a series of demonstration and case studies. In addition, over the past few years various national and international groups have applied the methodology to inform nuclear energy system designs, as well as to support the development of approaches to advanced safeguards. A number of international workshops have also been held which have introduced the methodology to design groups and other stakeholders. In this paper we summarize the technical progress and accomplishments of the PRPP evaluation methodology, including applications outside GIF, and we outline the PRPP methodology's relationship with the IAEA's INPRO methodology. Current challenges with the efficient implementation of the methodology are outlined, along with our path forward for increasing its accessibility to a broader stakeholder audience - including supporting the next generation of skilled professionals in the nuclear non-proliferation field. (author)

  8. A Review of Alloy 800H for Applications in the Gen IV Nuclear Energy Systems

    International Nuclear Information System (INIS)

    Ren, Weiju; Swindeman, Robert W.

    2010-01-01

    Alloy 800H is currently under consideration for applications in the Next Generation Nuclear Plant at operational temperatures above 750 C. To provide supporting information in this paper at the attempt to facilitate the consideration, service requirements of the nuclear system for structural materials is first described; and then an extensive review of Alloy 800H is given on its codification with respect to development and research history, mechanical behavior and design allowables, metallurgical aging resistance, environmental effect considerations, data requirements and availability, weldments, as well as many other aspects relevant to the intended nuclear application; an finally further research and development activities to support the materials qualification are suggested.

  9. Preparing Net Gen pre-service teachers for digital native classrooms

    Directory of Open Access Journals (Sweden)

    Valentin Ekiaka Nzai

    2014-09-01

    Full Text Available This paper explored Net Gen Bilingual pre-service teachers’ perspectives future digital native classrooms based on the National Education Technology Plan (2010 postulates. Participants were Seven Net Gen bilingual future teachers enrolled at a semester – long laboratory of practices project for Literacy Development for English Language Learners. Data were collected using Ginsburg’s (1989 narrative strategy, which consisted of analyzing information from participants’ life stories produced during two audiotaped focus group conversations. Findings showed that pre-service teachers had positive perceptions and beliefs toward the laboratory of practices built upon the experimental cyberlearning workstation frame designed by the authors. The hands-on experiences helped them enhance their digital native-like citizenship in order to meet future students’ individual abilities and learning styles, and stimulate teaching with digital technologies. Some recommendations and limitations are also addressed.

  10. Multi-criteria methodology to design a sodium-cooled carbide-fueled Gen-IV reactor

    International Nuclear Information System (INIS)

    Stauff, N.

    2011-01-01

    Compared with earlier plant designs (Phenix, Super-Phenix, EFR), Gen IV Sodium-cooled Fast Reactor requires improved economics while meeting safety and non-proliferation criteria. Mixed Oxide (U-Pu)O 2 fuels are considered as the reference fuels due to their important and satisfactory feedback experience. However, innovative carbide (U-Pu)C fuels can be considered as serious competitors for a prospective SFR fleet since carbide-fueled SFRs can offer another type of optimization which might overtake on some aspects the oxide fuel technology. The goal of this thesis is to reveal the potentials of carbide by designing an optimum carbide-fueled SFR with competitive features and a naturally safe behavior during transients. For a French nuclear fleet, a 1500 MW(e) break-even core is considered. To do so, a multi-physic approach was developed taking into account neutronics, fuel thermo-mechanics and thermal-hydraulic at a pre-design stage. Simplified modeling with the calculation of global neutronic feedback coefficients and a quasi-static evaluation was developed to estimate the behavior of a core during overpower transients, loss of flow and/or loss of heat removal transients. The breakthrough of this approach is to provide the designer with an overall view of the iterative process, emphasizing the well-suited innovations and the most efficient directions that can improve the SFR design project.This methodology was used to design a core that benefits from the favorable features of carbide fuels. The core developed is a large carbide-fueled SFR with high power density, low fissile inventory, break-even capability and forgiving behaviors during the un-scrammed transients studied that should prevent using expensive mitigate systems. However, the core-peak burnup is unlikely to significantly exceed 100 MWd/kg because of the large swelling of the carbide fuel leading to quick pellet-clad mechanical interaction and the low creep capacity of carbide. Moderate linear power fuel

  11. GenBank

    Data.gov (United States)

    U.S. Department of Health & Human ServicesGenBank is the NIH genetic sequence database, an annotated collection of all publicly available DNA sequences. GenBank is designed to provide and encourage access...

  12. Controlling applied to information processing: quality management applied to IP projects and IP services; Informationsverarbeitungs-Controlling: Qualitaetsmanagement fuer IV-Projekte und fuer IV-Service

    Energy Technology Data Exchange (ETDEWEB)

    Becker, B. [Vereinigung Deutscher Elektrizitaetswerke e.V. (VDEW), Frankfurt am Main (Germany); Beckers, F. [Isar-Amperwerke AG, Muenchen (Germany); Dewald, N. [Bayernwerk AG, Muenchen (Germany); Hauffe, P. [Pfalzwerke AG, Ludwigshafen am Rhein (Germany); Hein, F. [EVS AG Stuttgart (Germany); Hoederath, M. [Vereinigte Elektrizitaetswerke Westfalen AG (VEW), Dortmund (Germany); Seyen, R. [Staedtische Werke Nuernberg GmbH (Germany)

    1998-01-12

    The working group on information processing (IP) basics (in German: `IV-Grundlagen`) has prepared this contribution dealing with controlling applied to information processing. This new report, on the one hand, takes into consideration the role of the organizational IP unit as one offering its services to all sections of a company. On the other hand, information processing as an operational infrastructure influencing all business processes becomes increasingly important with respect to the competitiveness of the EVU. Therefore, quality management applied to IP projects and IP services must support this development. (orig./RHM) [Deutsch] Der VDEW Arbeitskreis `IV-Grundlagen` hat einen Beitrag zum Controlling fuer die Informationsverarbeitung erstellt. Hier geht zum einen die Rolle der Organisationseinheit IV als Dienstleister fuer alle Unternehmensbereiche ein. Zum anderen gewinnt die Informationsverarbeitung als betriebliche Infrastruktur fuer alle Geschaeftsprozesse zunehmende Bedeutung fuer die Wettbewerbsfaehigkeit der EVU. Das Qualitaetsmanagement fuer IV-Projekte und fuer IV-Service muss dies unterstuetzen. (orig./RHM)

  13. Optimized, Competitive Supercritical-CO2 Cycle GFR for Gen IV Service

    International Nuclear Information System (INIS)

    M.J. Driscoll; P. Hejzlar; G. Apostolakis

    2008-01-01

    An overall plant design was developed for a gas-cooled fast reactor employing a direct supercritical Brayton power conversion system. The most important findings were that (1) the concept could be capital-cost competitive, but startup fuel cycle costs are penalized by the low core power density, specified in large part to satisfy the goal of significant post-accident passive natural convection cooling; (2) active decay heat removal is preferable as the first line of defense, with passive performance in a backup role; (3) an innovative tube-in-duct fuel assembly, vented to the primary coolant, appears to be practicable; and (4) use of the S-Co2 GFR to support hydrogen production is a synergistic application, since sufficient energy can be recuperated from the product H2 and 02 to allow the electrolysis cell to run 250 C hotter than the reactor coolant, and the water boilers can be used for reactor decay heat removal. Increasing core power density is identified as the top priority for future work on GFRs of this type

  14. Gens Fera. The Wild men in the system of border decoration of the Bible of Wenceslas IV

    Czech Academy of Sciences Publication Activity Database

    Studničková, Milada

    2014-01-01

    Roč. 62, č. 3 (2014), s. 214-239 ISSN 0049-5123 R&D Projects: GA ČR GA13-39192S Institutional support: RVO:68378033 Keywords : book illumination * Bible of Wenceslas IV Subject RIV: AL - Art, Architecture, Cultural Heritage http://www.umeni-art.cz/admin/fileGet.aspx?v=issue-issue-2267-category-2268-paragraph-2269-pdf&l=cz

  15. A Qualitative Assessment Of Diversion Scenarios For A Example Sodium Fast Reactor Using The Gen IV PR And PP Methodology

    International Nuclear Information System (INIS)

    Zentner, Michael D.

    2008-01-01

    A working group was created in 2002 by the Generation IV International Forum (GIF) for the purpose of developing an internationally accepted methodology for assessing the Proliferation Resistance of a nuclear energy system (NES) and its individual elements. A two year case study is being performed by the experts group using this methodology to assess the proliferation resistance of a hypothetical NES called the Example Sodium Fast Reactor (ESFR). This work demonstrates how the PR and PP methodology can be used to provide important information at various levels of details to NES designers, safeguard administrators and decision makers. The study analyzes the response of the complete ESFR nuclear energy system to different proliferation and theft strategies. The challenges considered include concealed diversion, concealed misuse and 'break out' strategies. This paper describes the work done in performing a qualitative assessment of concealed diversion scenarios from the ESFR.

  16. A Qualitative Assessment of Diversion Scenarios for an Example Sodium Fast Reactor Using the GEN IV PR and PP Methodology

    International Nuclear Information System (INIS)

    Zentner, Michael D.; Coles, Garill A.; Therios, Ike

    2012-01-01

    FAST REACTORS;NUCLEAR ENERGY;NUCLEAR MATERIALS MANAGEMENT;PROLIFERATION;SAFEGUARDS;THEFT; A working group was created in 2002 by the Generation IV International Forum (GIF) for the purpose of developing an internationally accepted methodology for assessing the Proliferation Resistance of a nuclear energy system (NES) and its individual elements. A two year case study is being performed by the experts group using this methodology to assess the proliferation resistance of a hypothetical NES called the Example Sodium Fast Reactor (ESFR). This work demonstrates how the PR and PP methodology can be used to provide important information at various levels of details to NES designers, safeguard administrators and decision makers. The study analyzes the response of the complete ESFR nuclear energy system to different proliferation and theft strategies. The challenges considered include concealed diversion, concealed misuse and 'break out' strategies. This paper describes the work done in performing a qualitative assessment of concealed diversion scenarios from the ESFR.

  17. ASAMPSA2 best-practices guidelines for L2 PSA development and applications. Volume 3 - Extension to Gen IV reactors

    International Nuclear Information System (INIS)

    Bassi, C.; Bonneville, H.; Brinkman, H.; Burgazzi, L.; Polidoro, F.; Vincon, L.; Jouve, S.

    2010-01-01

    The main objective assigned to the Work Package 4 (WP4) of the 'ASAMPSA2' project (EC 7. FPRD) consist in the verification of the potential compliance of L2PSA guidelines based on PWR/BWR reactors (which are specific tasks of WP2 and WP3) with Generation IV representative concepts. Therefore, in order to exhibit potential discrepancies between LWRs and new reactor types, the following work was based on the up-to-date designs of: - The European Fast Reactor (EFR) which will be considered as prototypical of a pool-type Sodium-cooled Fast Reactor (SFR); - The ELSY design for the Lead-cooled Fast Reactor (LFR) technology; - The ANTARES project which could be representative of a Very-High Temperature Reactor (VHTR); - The CEA 2400 MWth Gas-cooled Fast Reactor (GFR). (authors)

  18. Economic, energy and GHG emissions performance evaluation of a WhisperGen Mk IV Stirling engine μ-CHP unit in a domestic dwelling

    International Nuclear Information System (INIS)

    Conroy, G.; Duffy, A.; Ayompe, L.M.

    2014-01-01

    Highlights: • The performance of a Stirling engine MK IV micro-CHP unit was evaluated in a domestic dwelling in Ireland. • The performance of the micro-CHP was compare to that of a condensing gas boiler. • The micro-CHP unit resulted in an annual cost saving of €180 compared to the condensing gas boiler. • Electricity imported from the grid decreased by 20.8% while CO 2 emissions decreased by 16.1%. • The micro-CHP unit used 2889 kW h of gas more than the condensing gas boiler during one year of operation. - Abstract: This paper presents an assessment of the energy, economic and greenhouse gas emissions performances of a WhisperGen Mk IV Stirling engine μ-CHP unit for use in a conventional house in the Republic of Ireland. The energy performance data used in this study was obtained from a field trial carried out in Belfast, Northern Ireland during the period June 2004–July 2005 by Northern Ireland Electricity and Phoenix Gas working in collaboration with Whispertech UK. A comparative performance analysis between the μ-CHP unit and a condensing gas boiler revealed that the μ-CHP unit resulted in an annual cost saving of €180 with an incremental simple payback period of 13.8 years when compared to a condensing gas boiler. Electricity imported from the grid decreased by 20.8% while CO 2 emissions decreased by 16.1%. The μ-CHP unit used 2889 kW h of gas more than the condensing gas boiler

  19. Unprotected Accident Analyses of the 1200MWe GEN-IV Sodium-Cooled Fast Reactor Using the SSC-K Code

    International Nuclear Information System (INIS)

    Kwon, Young Min; Lee, Kwi Lim; Ha, Kwi Seok; Jeong, Hae Yong; Chang, Won Pyo; Seok, Su Dong; Lee, Yong Bum

    2010-02-01

    A conceptual design of an advanced breakeven sodium-cooled fast reactor (G4SFR) has recently been developed by KAERI under the national nuclear R and D plan. The G4SFR is a 1,200MWe metal-fueled pool-type sodium-cooled fast reactor adopting advanced safety design features. The G4SFR development plan focuses on particular technology development efforts to effectively meet the goals of the Generation-IV (GEN-IV) nuclear system such as efficient utilization of resources, economic competitiveness, a high standard of safety, and enhanced proliferation resistance. To enhance the safety of G4SFR, advanced design features of metal-fueled core, simple and large sodium-inventory primary heat transport system, and passive safety decay heat removal system are included in the reactor design. To evaluate potential safety characteristics of such advanced design features, the plant responses and safety margins were investigated using the system transient code SSC-K for three unprotected accidents of UTOP, ULOF, and ULOHS. It was shown that the G4SFR design has inherent and passive safety characteristics and is accommodating the selected ATWS events. The inherent safety mechanism of the reactor design makes the core shutdown with sufficient margin and passive removal of decay heat with matching the core power to heat sink by passive self-regulation. The self-regulation of power without scram is mainly due to the inherent negative reactivity feedback in conjunction with the large thermal inertia of the primary heat transport system and the passive decay heat removal. Such favorable inherent and passive safety behaviors of G4SFR are expected to virtually exclude the probability of severe accidents with potential for core damage

  20. The web-enabled database of JRC-EC, a useful tool for managing European Gen IV materials data

    International Nuclear Information System (INIS)

    Over, H.H.; Dietz, W.

    2008-01-01

    Materials and document databases are important tools to conserve knowledge and experimental materials data of European R and D projects. A web-enabled application guarantees a fast access to these data. In combination with analysis tools the experimental data are used for e.g. mechanical design, construction and lifetime predictions of complex components. The effective and efficient handling of large amounts of generic and detailed materials data with regard to properties related to e.g. fabrication processes, joining techniques, irradiation or aging is one of the basic elements of data management within ongoing nuclear safety and design related European research projects and networks. The paper describes the structure and functionality of Mat-DB and gives examples how these tools can be used for the management and evaluation of materials data of European (national or multi-national) R and D activities or future reactor types such as the EURATOM FP7 Generation IV reactor types or the heavy liquid metals cooled reactor

  1. On the safety and performance demonstration tests of Prototype Gen-IV Sodium-Cooled Fast Reactor and validation and verification of computational codes

    International Nuclear Information System (INIS)

    Kim, Jong Bum; Jeong, Ji Young; Lee, Tae Ho; Kim, Sung Kyun; Euh, Dong Jin; Joo, Hyung Kook

    2016-01-01

    The design of Prototype Gen-IV Sodium-Cooled Fast Reactor (PGSFR) has been developed and the validation and verification (V and V) activities to demonstrate the system performance and safety are in progress. In this paper, the current status of test activities is described briefly and significant results are discussed. The large-scale sodium thermal-hydraulic test program, Sodium Test Loop for Safety Simulation and Assessment-1 (STELLA-1), produced satisfactory results, which were used for the computer codes V and V, and the performance test results of the model pump in sodium showed good agreement with those in water. The second phase of the STELLA program with the integral effect tests facility, STELLA-2, is in the detailed design stage of the design process. The sodium thermal-hydraulic experiment loop for finned-tube sodium-to-air heat exchanger performance test, the intermediate heat exchanger test facility, and the test facility for the reactor flow distribution are underway. Flow characteristics test in subchannels of a wire-wrapped rod bundle has been carried out for safety analysis in the core and the dynamic characteristic test of upper internal structure has been performed for the seismic analysis model for the PGSFR. The performance tests for control rod assemblies (CRAs) have been conducted for control rod drive mechanism driving parts and drop tests of the CRA under scram condition were performed. Finally, three types of inspection sensors under development for the safe operation of the PGSFR were explained with significant results

  2. On the safety and performance demonstration tests of Prototype Gen-IV Sodium-Cooled Fast Reactor and validation and verification of computational codes

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Jong Bum; Jeong, Ji Young; Lee, Tae Ho; Kim, Sung Kyun; Euh, Dong Jin; Joo, Hyung Kook [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2016-10-15

    The design of Prototype Gen-IV Sodium-Cooled Fast Reactor (PGSFR) has been developed and the validation and verification (V and V) activities to demonstrate the system performance and safety are in progress. In this paper, the current status of test activities is described briefly and significant results are discussed. The large-scale sodium thermal-hydraulic test program, Sodium Test Loop for Safety Simulation and Assessment-1 (STELLA-1), produced satisfactory results, which were used for the computer codes V and V, and the performance test results of the model pump in sodium showed good agreement with those in water. The second phase of the STELLA program with the integral effect tests facility, STELLA-2, is in the detailed design stage of the design process. The sodium thermal-hydraulic experiment loop for finned-tube sodium-to-air heat exchanger performance test, the intermediate heat exchanger test facility, and the test facility for the reactor flow distribution are underway. Flow characteristics test in subchannels of a wire-wrapped rod bundle has been carried out for safety analysis in the core and the dynamic characteristic test of upper internal structure has been performed for the seismic analysis model for the PGSFR. The performance tests for control rod assemblies (CRAs) have been conducted for control rod drive mechanism driving parts and drop tests of the CRA under scram condition were performed. Finally, three types of inspection sensors under development for the safe operation of the PGSFR were explained with significant results.

  3. Small angle neutron scattering study of nano sized microstructure in Fe-Cr ODS steels for gen IV in-core applications.

    Science.gov (United States)

    Han, Young-Soo; Mao, Xiadong; Jang, Jinsung

    2013-11-01

    The nano-sized microstructures in Fe-Cr oxide dispersion strengthened steel for Gen IV in-core applications were studied using small angle neutron scattering. The oxide dispersion strengthened steel was manufactured through hot isostatic pressing with various chemical compositions and fabrication conditions. Small angle neutron scattering experiments were performed using a 40 m small angle neutron scattering instrument at HANARO. Nano sized microstructures, namely, yttrium oxides and Cr-oxides were quantitatively analyzed by small angle neutron scattering. The yttrium oxides and Cr-oxides were also observed by transmission electron microscopy. The microstructural analysis results from small angle neutron scattering were compared with those obtained by transmission electron microscopy. The effects of the chemical compositions and fabrication conditions on the microstructure were investigated in relation to the quantitative microstructural analysis results obtained by small angle neutron scattering. The volume fraction of Y-oxide increases after fabrication, and this result is considered to be due to the formation of non-stochiometric Y-Ti-oxides.

  4. [Memorandum IV: Theoretical and Normative Grounding of Health Services Research].

    Science.gov (United States)

    Baumann, W; Farin, E; Menzel-Begemann, A; Meyer, T

    2016-05-01

    With Memoranda and other initiatives, the German Network for Health Service Research [Deutsches Netzwerk Versorgungsforschung e.V. (DNVF)] is fostering the methodological quality of care research studies for years. Compared to the standards of empirical research, questions concerning the role and function of theories, theoretical approaches and scientific principles have not been taken up on its own. Therefore, the DNVF e.V. has set up a working group in 2013, which was commissioned to prepare a memorandum on "theories in health care research". This now presented memorandum will primarily challenge scholars in health care services research to pay more attention to questions concerning the theoretical arsenal and the background assumptions in the research process. The foundation in the philosophy of science, the reference to normative principles and the theory-bases of the research process are addressed. Moreover, the memorandum will call on to advance the theorizing in health services research and to strengthen not empirical approaches, research on basic principles or studies with regard to normative sciences and to incorporate these relevant disciplines in health services research. Research structures and funding of health services research needs more open space for theoretical reflection and for self-observation of their own, multidisciplinary research processes. © Georg Thieme Verlag KG Stuttgart · New York.

  5. On the Safety and Performance Demonstration Tests of Prototype Gen-IV Sodium-Cooled Fast Reactor and Validation and Verification of Computational Codes

    Directory of Open Access Journals (Sweden)

    Jong-Bum Kim

    2016-10-01

    Full Text Available The design of Prototype Gen-IV Sodium-Cooled Fast Reactor (PGSFR has been developed and the validation and verification (V&V activities to demonstrate the system performance and safety are in progress. In this paper, the current status of test activities is described briefly and significant results are discussed. The large-scale sodium thermal-hydraulic test program, Sodium Test Loop for Safety Simulation and Assessment-1 (STELLA-1, produced satisfactory results, which were used for the computer codes V&V, and the performance test results of the model pump in sodium showed good agreement with those in water. The second phase of the STELLA program with the integral effect tests facility, STELLA-2, is in the detailed design stage of the design process. The sodium thermal-hydraulic experiment loop for finned-tube sodium-to-air heat exchanger performance test, the intermediate heat exchanger test facility, and the test facility for the reactor flow distribution are underway. Flow characteristics test in subchannels of a wire-wrapped rod bundle has been carried out for safety analysis in the core and the dynamic characteristic test of upper internal structure has been performed for the seismic analysis model for the PGSFR. The performance tests for control rod assemblies (CRAs have been conducted for control rod drive mechanism driving parts and drop tests of the CRA under scram condition were performed. Finally, three types of inspection sensors under development for the safe operation of the PGSFR were explained with significant results.

  6. Multi-scale approach to the modeling of fission gas discharge during hypothetical loss-of-flow accident in gen-IV sodium fast reactor

    Energy Technology Data Exchange (ETDEWEB)

    Behafarid, F.; Shaver, D. R. [Rensselaer Polytechnic Inst., Troy, NY (United States); Bolotnov, I. A. [North Carolina State Univ., Raleigh, NC (United States); Jansen, K. E. [Univ. of Colorado, Boulder, CO (United States); Antal, S. P.; Podowski, M. Z. [Rensselaer Polytechnic Inst., Troy, NY (United States)

    2012-07-01

    The required technological and safety standards for future Gen IV Reactors can only be achieved if advanced simulation capabilities become available, which combine high performance computing with the necessary level of modeling detail and high accuracy of predictions. The purpose of this paper is to present new results of multi-scale three-dimensional (3D) simulations of the inter-related phenomena, which occur as a result of fuel element heat-up and cladding failure, including the injection of a jet of gaseous fission products into a partially blocked Sodium Fast Reactor (SFR) coolant channel, and gas/molten sodium transport along the coolant channels. The computational approach to the analysis of the overall accident scenario is based on using two different inter-communicating computational multiphase fluid dynamics (CMFD) codes: a CFD code, PHASTA, and a RANS code, NPHASE-CMFD. Using the geometry and time history of cladding failure and the gas injection rate, direct numerical simulations (DNS), combined with the Level Set method, of two-phase turbulent flow have been performed by the PHASTA code. The model allows one to track the evolution of gas/liquid interfaces at a centimeter scale. The simulated phenomena include the formation and breakup of the jet of fission products injected into the liquid sodium coolant. The PHASTA outflow has been averaged over time to obtain mean phasic velocities and volumetric concentrations, as well as the liquid turbulent kinetic energy and turbulence dissipation rate, all of which have served as the input to the core-scale simulations using the NPHASE-CMFD code. A sliding window time averaging has been used to capture mean flow parameters for transient cases. The results presented in the paper include testing and validation of the proposed models, as well the predictions of fission-gas/liquid-sodium transport along a multi-rod fuel assembly of SFR during a partial loss-of-flow accident. (authors)

  7. search GenBank: interactive orchestration and ad-hoc choreography of Web services in the exploration of the biomedical resources of the National Center For Biotechnology Information.

    Science.gov (United States)

    Mrozek, Dariusz; Małysiak-Mrozek, Bożena; Siążnik, Artur

    2013-03-01

    Due to the growing number of biomedical entries in data repositories of the National Center for Biotechnology Information (NCBI), it is difficult to collect, manage and process all of these entries in one place by third-party software developers without significant investment in hardware and software infrastructure, its maintenance and administration. Web services allow development of software applications that integrate in one place the functionality and processing logic of distributed software components, without integrating the components themselves and without integrating the resources to which they have access. This is achieved by appropriate orchestration or choreography of available Web services and their shared functions. After the successful application of Web services in the business sector, this technology can now be used to build composite software tools that are oriented towards biomedical data processing. We have developed a new tool for efficient and dynamic data exploration in GenBank and other NCBI databases. A dedicated search GenBank system makes use of NCBI Web services and a package of Entrez Programming Utilities (eUtils) in order to provide extended searching capabilities in NCBI data repositories. In search GenBank users can use one of the three exploration paths: simple data searching based on the specified user's query, advanced data searching based on the specified user's query, and advanced data exploration with the use of macros. search GenBank orchestrates calls of particular tools available through the NCBI Web service providing requested functionality, while users interactively browse selected records in search GenBank and traverse between NCBI databases using available links. On the other hand, by building macros in the advanced data exploration mode, users create choreographies of eUtils calls, which can lead to the automatic discovery of related data in the specified databases. search GenBank extends standard capabilities of the

  8. Progress in the development of the neutron flux monitoring system of the French GEN-IV SFR: simulations and experimental validations [ANIMMA--2015-IO-392

    Energy Technology Data Exchange (ETDEWEB)

    Jammes, C.; Filliatre, P.; Izarra, G. de [CEA, DEN, Cadarache, Reactor Studies Department, 13108 Saint-Paul-lez-Durance (France); Elter, Zs. [CEA, DEN, Cadarache, Reactor Studies Department, 13108 Saint-Paul-lez-Durance (France); Chalmers University of Technology, Department of Applied Physics, Division of Nuclear Engineering, SE-412 96 Goeteborg (Sweden); Verma, V. [CEA, DEN, Cadarache, Reactor Studies Department, 13108 Saint-Paul-lez-Durance (France); Uppsala University, Division of Applied Nuclear Physics, Box 516, SE-75120 Uppsala (Sweden); Hamrita, H.; Bakkali, M. [CEA, DRT, LIST, Metrology, Instrumentation and Information Department, Saclay, 91191 Gif-sur-Yvette (France); Chapoutier, N.; Scholer, A.C.; Verrier, D. [AREVA NP, 10 rue Juliette Recamier F-69456 Lyon (France); Hellesen, C.; Jacobsson, S. [Uppsala University, Division of Applied Nuclear Physics, Box 516, SE-75120 Uppsala (Sweden); Pazsit, I. [Chalmers University of Technology, Department of Applied Physics, Division of Nuclear Engineering, SE-412 96 Goeteborg (Sweden); Cantonnet, B.; Nappe, J.C. [PHOTONIS France, Nuclear Instrumentation, 19100 Brive-la-Gaillarde (France); Molinie, P.; Dessante, P.; Hanna, R.; Kirkpatrick, M.; Odic, E. [Supelec, Energy Department, 3 rue Joliot-Curie, 91191 Gif-sur-Yvette (France)

    2015-07-01

    France has a long experience of about 50 years in designing, building and operating sodium-cooled fast reactors (SFR) such as RAPSODIE, PHENIX and SUPER PHENIX. Fast reactors feature the double capability of reducing nuclear waste and saving nuclear energy resources by burning actinides. Since this reactor type is one of those selected by the Generation IV International Forum, the French government asked, in the year 2006, CEA, namely the French Alternative Energies and Atomic Energy Commission, to lead the development of an innovative GEN-IV nuclear- fission power demonstrator. The major objective is to improve the safety and availability of an SFR. The neutron flux monitoring (NFM) system of any reactor must, in any situation, permit both reactivity control and power level monitoring from startup to full power. It also has to monitor possible changes in neutron flux distribution within the core region in order to prevent any local melting accident. The neutron detectors will have to be installed inside the reactor vessel because locations outside the vessel will suffer from severe disadvantages; radially the neutron shield that is also contained in the reactor vessel will cause unacceptable losses in neutron flux; below the core the presence of a core-catcher prevents from inserting neutron guides; and above the core the distance is too large to obtain decent neutron signals outside the vessel. Another important point is to limit the number of detectors placed in the vessel in order to alleviate their installation into the vessel. In this paper, we show that the architecture of the NFM system will rely on high-temperature fission chambers (HTFC) featuring wide-range flux monitoring capability. The definition of such a system is presented and the justifications of technological options are brought with the use of simulation and experimental results. Firstly, neutron-transport calculations allow us to propose two in-vessel regions, namely the above-core and under

  9. Overview of materials R and D for fusion and Gen-4

    Energy Technology Data Exchange (ETDEWEB)

    Kohyama, A. [Kyoto Univ., lnstitute of Advanced Energy (Japan); Tavassoli, F.; Carre, F.; Billot, P. [CEA Saclay, 91 - Gif sur Yvette (France); Zinide, S. [Oak Ridge National Laboratory, Materials Science and Technology Div., AK TN (United States)

    2007-07-01

    Full text of publication follows: In view of the growing need for energy, the risk of exhaustion of fossil fuel and the problem of global warming, the nuclear energy is receiving added attention as a realistic and viable advanced solution. International collaborations on Generation IV (Gen-IV) fission reactors and on ITER and DEMO fusion reactors are developing. This is particularly the case in the sector of materials, where they hold the key to success of these systems. The international community has recognized and planned its materials R and D work for Fusion and Gen-IV reactors with the following considerations: 1- The time allotted to materials R and D is short and may not allow development of totally new materials. 2- Activities required, to cover existing materials variations and service conditions necessary for reactor design, are very time consuming. 3- The work to be done must build upon the existing knowledge of materials and avoid duplications. Although ITER for fusion and Generation four International Forum (GIF) for Gen-IV are important international collaborative programs, they are insufficient to meet all the national energy policies of the participating countries. This paper provides an overview of the materials R and D carried out for fusion and Gen-IV reactors at international and national levels. Materials programs discussed include both cross-cutting and reactor specific actions, where major tasks can be defined as: + Cross-cutting materials tasks: - materials for high temperature service; - materials with neutron damage tolerance; - materials behavior analysis and modeling; - high temperature design methodology. + Reactor specific materials tasks: - very high temperature alloys; - carbon, high temperature ceramics and their composites; - materials compatibilities. Starting with a brief introduction of materials R and D strategies, ITER and Broader Approach (BA), overall activities for fusion and GIF for Gen-IV will be reviewed. Domestic

  10. The energy consumption of the services and farming sectors 1990 - 2035 - Results of scenarios I - IV

    International Nuclear Information System (INIS)

    Aebischer, B.; Catenazzi, G.

    2007-01-01

    This comprehensive report for the Swiss Federal Office of Energy (SFOE) presents four scenarios concerning the development of energy consumption in the services sector and for farming for the period 1990 - 2035. The four scenarios - status quo, increased co-operation between the state and the economy with various levies, global reduction of energy consumption and, finally, scenario IV 'on the way to a 2000-Watt Society' - are briefly described. In particular, the scenarios are examined for various sensitivities: high gross domestic product GDP, CO 2 levy, high prices and warmer climate. The models and methods used are examined and examples of their use are quoted. The results of the sensitivity analyses are compared and discussed and the necessary instruments are examined. This comprehensive report contains a large number of data-tables and graphical representations

  11. Feasibility study for the computerized automation of the Laboratory Services Branch of EPA Region IV

    International Nuclear Information System (INIS)

    Boyle, W.G. Jr.; Barton, G.W. Jr.; Taber, L.

    1978-01-01

    This report is a study of the feasibility of computerized automation of the Laboratory Services Branch of the Environmental Protection Agency's Region IV. The LSB provides chemical analytical support for a number of EPA divisions; its primary function at present is compliance monitoring, field surveys, and oil identification. Automation of the LSB is not only feasible but also highly desirable. Automation systems are proposed that will make major improvements in analytical capacity, quality control, sample management, and reporting capabilities. Most of these automation systems are similar to those already developed and installed at other EPA laboratories. These systems have options that include limited modifications suggested as a result of the study of the LSB Laboratory, and also include communications hardware and software for a Sample File Control host computer. It is estimated that the initial cost of three of the four options considered would be recouped in approximately three years through increased capacity and efficiency of operation

  12. AN ASSESSMENT OF THE SERVICE HISTORY AND CORROSION SUSCEPTIBILITY OF TYPE IV WASTE TANKS

    International Nuclear Information System (INIS)

    Wiersma, B

    2008-01-01

    Type IV waste tanks were designed and built to store waste that does not require auxiliary cooling. Each Type IV tank is a single-shell tank constructed of a steel-lined pre-stressed concrete tank in the form of a vertical cylinder with a concrete domed roof. There are four such tanks in F-area, Tanks 17-20F, and four in H-Area, Tanks 21-24H. Leak sites were discovered in the liners for Tanks 19 and 20F in the 1980's. Although these leaks were visually observed, the investigation to determine the mechanism by which the leaks had occurred was not completed at that time. Therefore, a concern was raised that the same mechanism which caused the leak sites in the Tanks in F-area may also be operable in the H-Area tanks. Data from the construction of the tanks (i.e., certified mill test reports for the steel, no stress-relief), the service history (i.e., waste sample data, temperature data), laboratory tests on actual wastes and simulants (i.e., electrochemical testing), and the results of the visual inspections were reviewed. The following observations and conclusions were made: (1) Comparison of the compositional and microstructural features indicate that the A212 material utilized for construction of the H-Area tanks are far more resistant to SCC than the A285 materials used for construction of the F-Area tanks. (2) A review of the materials of construction, temperature history, service histories concluded that F-Area tanks likely failed by caustic stress corrosion cracking. (3) The environment in the F-Area tanks was more aggressive than that experienced by the H-Area tanks. (4) Based on a review of the service history, the H-Area tanks have not been exposed to an environment that would render the tanks susceptible to either nitrate stress corrosion cracking (i.e., the cause of failures in the Type I and II tanks) or caustic stress corrosion cracking. (5) Due to the very dilute and uninhibited solutions that have been stored in Tank 23H, vapor space corrosion has

  13. Health services utilization by school going Omani adolescents and youths with DSM IV mental disorders and barriers to service use

    Directory of Open Access Journals (Sweden)

    Morsi Magdi M

    2009-09-01

    Full Text Available Abstract Background Recent corpus of research suggests that psychiatric disorders amongst adolescents and youths are an emerging global challenge, but there is paucity of studies exploring health services utilization by this age group in Arab region. Aim This study focus on the health services utilization and the barriers among school going adolescents and youths with DSM IV disorders in the country Oman, whose population is predominantly youthful. Methods Representative sample of secondary school Omani adolescents and youths were concurrently interviewed for the (i presence of DSM IV mental disorders using the face-to-face interview, World Mental Health-Composite International Diagnostic Interview (WMH-CIDI, (ii tendency for health care utilization and (iii predictors of utilization with clinical and demographic background. Results The proportions of lifetime cases having ever made treatment contact are low, being 5.2% for any anxiety disorder and 13.2% for any mood disorder category. None of these anxiety cases made treatment contact in the year of onset of the disorder, and the median delay when they eventually made treatment contact is about 14 years. In any mood disorders category only 3.6% made contact within the 1st year of onset with the median delay in initial treatment contact is two years for the Bipolar disorder (broad, four years for Any Mood disorder and nine years for the Major Depressive Disorder group. Male gender is significantly associated with less likelihood of making treatment contact when suffering from Social phobia (p = 0.000, Major Depressive Disorder (p = 0.000 and Bipolar Disorder (p = 0.000. The younger cohorts of 14-16 years and 17-18 years of Social phobic made significantly less lifetime any treatment contact (p = 0.000. The 14-16 year olds were significantly less likely to make lifetime any treatment contact for Bipolar Mood disorder (p = 0.000, while the 17-18 group were 1.5 times more likely to do so. Over past

  14. From a LWR monoculture to a synergistic use of nuclear systems. Introducing a new way of looking at GEN-IV economics

    International Nuclear Information System (INIS)

    Laeuferts, U.; Heek, A. van; Anderluh, J.

    2009-01-01

    The authors discuss the value that fast reactor technologies add to the current LWR design by hedging against uncertainties in the front-end and back-end of the fuel cycle. Using Monte Carlo simulation for these underlying uncertainties in fuel cycle costs the authors found in a first explorative attempt an approximation for the real option value. The model oversimplifies the demand/supply site of the fuel cycle services and is not exhaustive concerning all fuel cycle options, but gives first impression over the benefits of introducing real option thinking.Future work could give a good indication about the thresholds of fuel cycle services and transaction costs, including the development and timing of additional reprocessing and fuel fabrication plants.

  15. GenBank.

    OpenAIRE

    Benson, D; Lipman, D J; Ostell, J

    1993-01-01

    The GenBank sequence database has undergone an expansion in data coverage, annotation content and the development of new services for the scientific community. In addition to nucleotide sequences, data from the major protein sequence and structural databases, and from U.S. and European patents is now included in an integrated system. MEDLINE abstracts from published articles describing the sequences provide an important new source of biological annotation for sequence entries. In addition to ...

  16. Condensation and homogenization of cross sections for the deterministic transport codes with Monte Carlo method: Application to the GEN IV fast neutron reactors

    International Nuclear Information System (INIS)

    Cai, Li

    2014-01-01

    In the framework of the Generation IV reactors neutronic research, new core calculation tools are implemented in the code system APOLLO3 for the deterministic part. These calculation methods are based on the discretization concept of nuclear energy data (named multi-group and are generally produced by deterministic codes) and should be validated and qualified with respect to some Monte-Carlo reference calculations. This thesis aims to develop an alternative technique of producing multi-group nuclear properties by a Monte-Carlo code (TRIPOLI-4). At first, after having tested the existing homogenization and condensation functionalities with better precision obtained nowadays, some inconsistencies are revealed. Several new multi-group parameters estimators are developed and validated for TRIPOLI-4 code with the aid of itself, since it has the possibility to use the multi-group constants in a core calculation. Secondly, the scattering anisotropy effect which is necessary for handling neutron leakage case is studied. A correction technique concerning the diagonal line of the first order moment of the scattering matrix is proposed. This is named the IGSC technique and is based on the usage of an approximate current which is introduced by Todorova. An improvement of this IGSC technique is then presented for the geometries which hold an important heterogeneity property. This improvement uses a more accurate current quantity which is the projection on the abscissa X. The later current can represent the real situation better but is limited to 1D geometries. Finally, a B1 leakage model is implemented in the TRIPOLI-4 code for generating multi-group cross sections with a fundamental mode based critical spectrum. This leakage model is analyzed and validated rigorously by the comparison with other codes: Serpent and ECCO, as well as an analytical case.The whole development work introduced in TRIPOLI-4 code allows producing multi-group constants which can then be used in the core

  17. Regulatory Safety Issues in the Structural Design Criteria of ASME Section III Subsection NH and for Very High Temperatures for VHTR and GEN IV

    International Nuclear Information System (INIS)

    O'Donnell, William J.; Griffin, Donald S.

    2007-01-01

    The objective of this task is to identify issues relevant to ASME Section III, Subsection NH [1], and related Code Cases that must be resolved for licensing purposes for VHTGRs (Very High Temperature Gas Reactor concepts such as those of PBMR, Areva, and GA); and to identify the material models, design criteria, and analysis methods that need to be added to the ASME Code to cover the unresolved safety issues. Subsection NH was originally developed to provide structural design criteria and limits for elevated-temperature design of Liquid Metal Fast Breeder Reactor (LMFBR) systems and some gas-cooled systems. The U.S. Nuclear Regulatory Commission (NRC) and its Advisory Committee for Reactor Safeguards (ACRS) reviewed the design limits and procedures in the process of reviewing the Clinch River Breeder Reactor (CRBR) for a construction permit in the late 1970s and early 1980s, and identified issues that needed resolution. In the years since then, the NRC and various contractors have evaluated the applicability of the ASME Code and Code Cases to high-temperature reactor designs such as the VHTGRs, and identified issues that need to be resolved to provide a regulatory basis for licensing. This Report describes: (1) NRC and ACRS safety concerns raised during the licensing process of CRBR , (2) how some of these issues are addressed by the current Subsection NH of the ASME Code; and (3) the material models, design criteria, and analysis methods that need to be added to the ASME Code and Code Cases to cover unresolved regulatory issues for very high temperature service.

  18. Regulatory Safety Issues in the Structural Design Criteria of ASME Section III Subsection NH and for Very High Temperatures for VHTR & GEN IV

    Energy Technology Data Exchange (ETDEWEB)

    William J. O’Donnell; Donald S. Griffin

    2007-05-07

    The objective of this task is to identify issues relevant to ASME Section III, Subsection NH [1], and related Code Cases that must be resolved for licensing purposes for VHTGRs (Very High Temperature Gas Reactor concepts such as those of PBMR, Areva, and GA); and to identify the material models, design criteria, and analysis methods that need to be added to the ASME Code to cover the unresolved safety issues. Subsection NH was originally developed to provide structural design criteria and limits for elevated-temperature design of Liquid Metal Fast Breeder Reactor (LMFBR) systems and some gas-cooled systems. The U.S. Nuclear Regulatory Commission (NRC) and its Advisory Committee for Reactor Safeguards (ACRS) reviewed the design limits and procedures in the process of reviewing the Clinch River Breeder Reactor (CRBR) for a construction permit in the late 1970s and early 1980s, and identified issues that needed resolution. In the years since then, the NRC and various contractors have evaluated the applicability of the ASME Code and Code Cases to high-temperature reactor designs such as the VHTGRs, and identified issues that need to be resolved to provide a regulatory basis for licensing. This Report describes: (1) NRC and ACRS safety concerns raised during the licensing process of CRBR , (2) how some of these issues are addressed by the current Subsection NH of the ASME Code; and (3) the material models, design criteria, and analysis methods that need to be added to the ASME Code and Code Cases to cover unresolved regulatory issues for very high temperature service.

  19. Building competencies for New Gen IV Reactors

    International Nuclear Information System (INIS)

    Pavel, G.L.; Ghitescu, P.

    2015-01-01

    The Advanced Lead Fast Reactor European Demonstrator - ALFRED is designed and sustained by several European countries. It is a 300 MWt (125 MWe) reactor, intended to be built in Romania, near the Pitesti site. Pure lead is used as primary coolant and it is foreseen to have a 40% thermal efficiency. Secondary cycle contains superheated water steam at around 450 Celsius degrees. Through ARCADIA cooperation, 26 partners from all over Europe joined their forces to provide the necessary research support for ALFRED. In Romania, several entities are providing nuclear courses but only the University Politechnica of Bucharest is offering a complete training program for nuclear industry but targeted courses for LFR technology need to be developed and implemented. Issues like physics of breeding, coolant analysis and behavior, targeted computer codes, core design and dynamics, safety still needs to be tackled

  20. Ideation of IoT services with citizen: coupling GenIoT and AloHa! methods

    OpenAIRE

    Negri , Anne-Laure; Trousse , Brigitte; Senach , Bernard

    2012-01-01

    International audience; This paper introduces a methodology for designing service concepts in the specific paradigm of the Internet of Things (IoT). In the frame of the European project ELLIOT - Experiential Living Lab for Internet Of Things -, the Living Lab ICT Usage Lab aims at co-creating "green" services, i.e. services based on air quality and noise measurement. These services are invented in an open innovation setting, by a set of stakeholders and not a given service provider. In this c...

  1. A service evaluation of the Gen-Probe APTIMA nucleic acid amplification test for Trichomonas vaginalis: should it change whom we screen for infection?

    Science.gov (United States)

    Hathorn, Emma; Ng, Andrea; Page, Matthew; Hodson, James; Gaydos, Charlotte; Ross, Jonathan D C

    2015-01-01

    Objective A service evaluation of the new Gen-Probe APTIMA nucleic acid amplification test was performed to determine the prevalence of Trichomonas vaginalis (TV) infection in a UK sexual health clinic and identify risk factors to inform an appropriate TV screening strategy. Method Unselected patients presenting with a new clinical episode were offered TV testing with Gen Probe transcription-mediated amplification (TV TMA) in addition to routine sexually transmitted infection screening. Asymptomatic females provided a self-collected vulvovaginal specimen and asymptomatic men a first-void urine sample. Symptomatic patients were examined and a urethral swab taken from men and two posterior vaginal swabs from females; one for culture and one for TV TMA testing. Demographic and clinical data were collected on all patients positive for TV infection and 100 randomly selected TV-negative controls. Results 3503 patients underwent TV TMA testing during the evaluation period. The prevalence of TV infection was 21/1483, 1.4% (95% CI 0.9% to 2.2%) in men and 72/2020, 3.6% (95% CI 2.8% to 4.5%) in women. The rate of TV positivity was higher in Black Caribbean patients compared with Caucasian patients (men 5.4% vs 0.1%, pwomen 9.0% vs 1.2%, pTV TMA detected an additional 16 infections (38%) in symptomatic women compared with culture. Conclusions While screening all patients with TV TMA will identify more TV infections, the UK prevalence remains low and this approach is unlikely to be cost effective. In addition to testing symptomatic patients, targeted testing of high-risk asymptomatic groups using TV TMA should be considered. PMID:25170162

  2. IVS Organization

    Science.gov (United States)

    2004-01-01

    International VLBI Service (IVS) is an international collaboration of organizations which operate or support Very Long Baseline Interferometry (VLBI) components. The goals are: To provide a service to support geodetic, geophysical and astrometric research and operational activities. To promote research and development activities in all aspects of the geodetic and astrometric VLBI technique. To interact with the community of users of VLBI products and to integrate VLBI into a global Earth observing system.

  3. Service for maintenance of electronic equipment of the RA reactor, Report for 1977 - Annex IV

    International Nuclear Information System (INIS)

    Milosevic, M.

    1977-01-01

    This report describes the tasks and organizational structure of the Service for maintenance of electronic equipment of the RA reactor. The most important task of this Service is control and maintenance of the reactor control and protection instruments, operation control, and dosimetry system. Besides data about this basic instrumentation, the report includes data about control and maintenance of other electronic equipment related to the experimental devices [sr

  4. GenBank

    OpenAIRE

    Benson, Dennis A.; Karsch-Mizrachi, Ilene; Lipman, David J.; Ostell, James; Rapp, Barbara A.; Wheeler, David L.

    2002-01-01

    The GenBank sequence database incorporates publicly available DNA sequences of more than 105 000 different organisms, primarily through direct submission of sequence data from individual laboratories and large-scale sequencing projects. Most submissions are made using the BankIt (web) or Sequin programs and accession numbers are assigned by GenBank staff upon receipt. Data exchange with the EMBL Data Library and the DNA Data Bank of Japan helps ensure comprehensive worldwide coverage. GenBank...

  5. GenBank

    OpenAIRE

    Benson, Dennis A.; Karsch-Mizrachi, Ilene; Lipman, David J.; Ostell, James; Wheeler, David L.

    2006-01-01

    GenBank (R) is a comprehensive database that contains publicly available nucleotide sequences for more than 240 000 named organisms, obtained primarily through submissions from individual laboratories and batch submissions from large-scale sequencing projects. Most submissions are made using the web-based BankIt or standalone Sequin programs and accession numbers are assigned by GenBank staff upon receipt. Daily data exchange with the EMBL Data Library in Europe and the DNA Data Bank of Japan...

  6. GenBank

    OpenAIRE

    Benson, Dennis A.; Karsch-Mizrachi, Ilene; Lipman, David J.; Ostell, James; Sayers, Eric W.

    2008-01-01

    GenBank? is a comprehensive database that contains publicly available nucleotide sequences for more than 300 000 organisms named at the genus level or lower, obtained primarily through submissions from individual laboratories and batch submissions from large-scale sequencing projects. Most submissions are made using the web-based BankIt or standalone Sequin programs, and accession numbers are assigned by GenBank? staff upon receipt. Daily data exchange with the European Molecular Biology Labo...

  7. GenBank

    OpenAIRE

    Benson, Dennis A.; Cavanaugh, Mark; Clark, Karen; Karsch-Mizrachi, Ilene; Lipman, David J.; Ostell, James; Sayers, Eric W.

    2012-01-01

    GenBank? (http://www.ncbi.nlm.nih.gov) is a comprehensive database that contains publicly available nucleotide sequences for almost 260 000 formally described species. These sequences are obtained primarily through submissions from individual laboratories and batch submissions from large-scale sequencing projects, including whole-genome shotgun (WGS) and environmental sampling projects. Most submissions are made using the web-based BankIt or standalone Sequin programs, and GenBank staff assig...

  8. NNDSS - Table IV. Tuberculosis

    Data.gov (United States)

    U.S. Department of Health & Human Services — NNDSS - Table IV. Tuberculosis - 2016.This Table includes total number of cases reported in the United States, by region and by states, in accordance with the...

  9. NNDSS - Table IV. Tuberculosis

    Data.gov (United States)

    U.S. Department of Health & Human Services — NNDSS - Table IV. Tuberculosis - 2014.This Table includes total number of cases reported in the United States, by region and by states, in accordance with the...

  10. NNDSS - Table IV. Tuberculosis

    Data.gov (United States)

    U.S. Department of Health & Human Services — NNDSS - Table IV. Tuberculosis - 2015.This Table includes total number of cases reported in the United States, by region and by states, in accordance with the...

  11. Materials for generation-IV nuclear reactors

    International Nuclear Information System (INIS)

    Alvarez, M. G.

    2009-01-01

    Materials science and materials development are key issues for the implementation of innovative reactor systems such as those defined in the framework of the Generation IV. Six systems have been selected for Generation IV consideration: gas-cooled fast reactor, lead-cooled fast reactor, molten salt-cooled reactor, sodium-cooled fast reactor, supercritical water-cooled reactor, and very high temperature reactor. The structural materials need to resist much higher temperatures, higher neutron doses and extremely corrosive environment, which are beyond the experience of the current nuclear power plants. For this reason, the first consideration in the development of Generation-IV concepts is selection and deployment of materials that operate successfully in the aggressive operating environments expected in the Gen-IV concepts. This paper summarizes the Gen-IV operating environments and describes the various candidate materials under consideration for use in different structural applications. (author)

  12. DETEKSI GEN-GEN PENYANDI FAKTOR VIRULENSI PADA BAKTERI VIBRIO

    Directory of Open Access Journals (Sweden)

    Ince Ayu Khairani Kadriah

    2011-04-01

    menggunakan isolat bakteri yang diisolasi dari budidaya udang windu di berbagai daerah di Sulawesi Selatan dan Jawa. Pada penelitian ini digunakan primer spesifik untuk mendeteksi gen-gen virulen toxR gene, hemolysin (vvh gene, dan GyrB gene dengan metode PCR. Dari 35 isolat yang diisolasi, 20 isolat terdeteksi memiliki gen virulensi dan 8 di antaranya memiliki dua gen virulen. Spesies bakteri yang memiliki gen virulen adalah: V.harveyi, V. parahaemolyticus, V. mimicus, dan V. campbelli

  13. 45 CFR 1357.32 - State fiscal requirements (title IV-B, subpart 2, family preservation and family support services).

    Science.gov (United States)

    2010-10-01

    ... property; data processing and computer services; accounting; budgeting; auditing. (3) Program costs are... (e.g., delivery of services, planning, consultation, coordination, training, quality assurance..., family preservation and family support services). 1357.32 Section 1357.32 Public Welfare Regulations...

  14. MO-DE-304-01: The Abt Study of Medical Physicist Work Values for Radiation Oncology Physics Services: Round IV

    International Nuclear Information System (INIS)

    Mills, M.

    2015-01-01

    The Abt study of medical physicist work values for radiation oncology physics services, Round IV is completed. It supersedes the Abt III study of 2008. The 2015 Abt study measured qualified medical physicist (QMP) work associated with routine radiation oncology procedures as well as some special procedures. As before, a work model was created to allow the medical physicist to defend QMP work based on both routine and special procedures service mix. The work model can be used to develop a cost justification report for setting charges for radiation oncology physics services. The Abt study Round IV was designed to empower the medical physicist to negotiate a service or employment contract with providers based on measured national QMP workforce and staffing data. For a variety of reasons, the diagnostic imaging contingent of AAPM has had a more difficult time trying estimate workforce requirements than their therapy counterparts. Over the past several years, the Diagnostic Work and Workforce Study Subcommittee (DWWSS) has collected survey data from AAPM members, but the data have been very difficult to interpret. The DWWSS has reached out to include more AAPM volunteers to create a more full and accurate representation of actual clinical practice models on the subcommittee. Though much work remains, through hours of discussion and brainstorming, the DWWSS has somewhat of a clear path forward. This talk will provide attendees with an update on the efforts of the subcommittee. Learning Objectives: Understand the new information documented in the Abt studies. Understand how to use the Abt studies to justify medical physicist staffing. Learn relevant historical information on imaging physicist workforce. Understand the process of the DWWSS in 2014. Understand the intended path forward for the DWWSS

  15. MO-DE-304-01: The Abt Study of Medical Physicist Work Values for Radiation Oncology Physics Services: Round IV

    Energy Technology Data Exchange (ETDEWEB)

    Mills, M. [James Graham Brown Cancer Center (United States)

    2015-06-15

    The Abt study of medical physicist work values for radiation oncology physics services, Round IV is completed. It supersedes the Abt III study of 2008. The 2015 Abt study measured qualified medical physicist (QMP) work associated with routine radiation oncology procedures as well as some special procedures. As before, a work model was created to allow the medical physicist to defend QMP work based on both routine and special procedures service mix. The work model can be used to develop a cost justification report for setting charges for radiation oncology physics services. The Abt study Round IV was designed to empower the medical physicist to negotiate a service or employment contract with providers based on measured national QMP workforce and staffing data. For a variety of reasons, the diagnostic imaging contingent of AAPM has had a more difficult time trying estimate workforce requirements than their therapy counterparts. Over the past several years, the Diagnostic Work and Workforce Study Subcommittee (DWWSS) has collected survey data from AAPM members, but the data have been very difficult to interpret. The DWWSS has reached out to include more AAPM volunteers to create a more full and accurate representation of actual clinical practice models on the subcommittee. Though much work remains, through hours of discussion and brainstorming, the DWWSS has somewhat of a clear path forward. This talk will provide attendees with an update on the efforts of the subcommittee. Learning Objectives: Understand the new information documented in the Abt studies. Understand how to use the Abt studies to justify medical physicist staffing. Learn relevant historical information on imaging physicist workforce. Understand the process of the DWWSS in 2014. Understand the intended path forward for the DWWSS.

  16. Generation IV nuclear reactors: Current status and future prospects

    International Nuclear Information System (INIS)

    Locatelli, Giorgio; Mancini, Mauro; Todeschini, Nicola

    2013-01-01

    Generation IV nuclear power plants (GEN IV NPPs) are supposed to become, in many countries, an important source of base load power in the middle–long term (2030–2050). Nowadays there are many designs of these NPPs but for political, strategic and economic reasons only few of them will be deployed. International literature proposes many papers and reports dealing with GEN IV NPPs, but there is an evident difference in the types and structures of the information and a general unbiased overview is missing. This paper fills the gap, presenting the state-of-the-art for GEN IV NPPs technologies (VHTR, SFR, SCWR, GFR, LFR and MSR) providing a comprehensive literature review of the different designs, discussing the major R and D challenges and comparing them with other advanced technologies available for the middle- and long-term energy market. The result of this research shows that the possible applications for GEN IV technologies are wider than current NPPs. The economics of some GEN IV NPPs is similar to actual NPPs but the “carbon cost” for fossil-fired power plants would increase the relative valuation. However, GEN IV NPPs still require substantial R and D effort, preventing short-term commercial adoption. - Highlights: • Generation IV reactors are the middle–long term technology for nuclear energy. • This paper provides an overview and a taxonomy for the designs under consideration. • R and D efforts are in the material, heat exchangers, power conversion unit and fuel. • The life cycle costs are competitive with other innovative technologies. • The hydrogen economy will foster the development of Generation IV reactors

  17. GEN IV: Carbide Fuel Elaboration for the 'Futurix Concepts' experiment

    International Nuclear Information System (INIS)

    Vaudez, Stephane; Riglet-Martial, Chantal; Paret, Laurent; Abonneau, Eric

    2008-01-01

    In order to collect information on the behaviour of the future GFR (Gas Fast Reactor) fuel under fast neutron irradiation, an experimental irradiation program, called 'Futurix-concepts' has been launched at the CEA. The considered concept is a composite material made of a fissile fuel embedded in an inert ceramic matrix. Fissile fuel pellets are made of UPuN or UPuC while ceramics are SiC for the carbide fuel and TiN for the nitride fuel. This paper focuses on the description of the carbide composite fabrication. The UPuC pellets are manufactured using a metallurgical powder process. Fabrication and handling of the fuels are carried out in glove boxes under a nitrogen atmosphere. Carbide fuel is synthesized by carbo-thermic reduction under vacuum of a mixture of actinide oxide and graphitic carbon up to 1550 deg. C. After ball milling, the UPuC powder is pressed to create hexagonal or spherical compacts. They are then sintered up to 1750 deg. C in order to obtain a density of 85 % of the theoretical one. The sintered pellets are inserted into an inert and tight capsule of SiC. In order to control the gap between the fuel and the matrix precisely, the pellets are abraded. The inert matrix is then filled with the pellets and the whole system is sealed by a BRASiC R process at high temperature under a helium atmosphere. Fabrication of the sample to be irradiated was done in 2006 and the irradiation began in May 2007 in the Phenix reactor. This presentation will detail and discuss the results obtained during this fabrication phase. (authors)

  18. Activity of the Service for maintenance of the electronic equipment of the RA reactor in 1976, report - Annex IV

    International Nuclear Information System (INIS)

    Milosevic, M.

    1976-01-01

    Within the organizational structure of the RA reactor staff, the Service for instrumentation maintenance has the following tasks: maintenance of the existing electronic equipment; participating in experiments planning and preparation of electronic equipment; purchasing new equipment, spare parts and components; construction of new equipment for internal needs; implementation of new equipment. Basic instrumentation of the reactor facility includes: control and protection system, and dosimetry system [sr

  19. Internet Economics IV

    Science.gov (United States)

    2004-08-01

    edts.): Internet Economics IV Technical Report No. 2004-04, August 2004 Information Systems Laboratory IIS, Departement of Computer Science University of...level agreements (SLA), Information technology (IT), Internet address, Internet service provider 16. PRICE CODE 17. SECURITY CLASSIFICATION 18... technology and its economic impacts in the Internet world today. The second talk addresses the area of AAA protocol, summarizing authentication

  20. Key Factors for the Linkage Strategy between R and D and Commercialization for Gen-ΙV

    International Nuclear Information System (INIS)

    Lee, Kyoungmi; Hong, Jung Suk

    2013-01-01

    The Fukushima nuclear disaster has leaded to enhance the safety and the cost-effectiveness of technology for the future so that advanced countries such as United Sates and France have concerned about a next generation nuclear power plant, Gen-IV(Generation-IV Reactor). Considering various characteristics of nuclear R and D, it is necessary to have more elaborated strategies for the effective development of the next generation of nuclear technology. In this study, we suggest 5 key factors for the successful commercialization of Gen-IV by analyzing the distinct characteristics of nuclear R and D with Gen-IV and CSF(Critical Success Factor)s of several cases in these field and conducting the FGI(Focus Group Interview). Considering these results, we could find and suggest some important points for further strategy for Gen-IV. That is, following five key factors for the linkage improvement between R and D and commercialization of Gen-IV should be considered: the participation of nuclear power plant operators from the beginning, the establishment of consistent and comprehensive plan/roadmap/detailed strategy, the technology development based on global energy issues and international cooperation, the stable and clear funding plans for long-term projects, the cooperation of relative ministries. Gen-IV system is getting a positive response in that it accompanies long-term R and D plans in Korea. We think that the standard of Gen-IV would lead the next generation of nuclear industry if the proper strategy for the cooperation between the private sector and the regulation from the beginning. Moreover, we expect that this study will facilitate its development process from R and D to commercialization

  1. Key Factors for the Linkage Strategy between R and D and Commercialization for Gen-ΙV

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Kyoungmi; Hong, Jung Suk [Korean Institute of S and T Evaluation and Planning, Seoul (Korea, Republic of)

    2013-05-15

    The Fukushima nuclear disaster has leaded to enhance the safety and the cost-effectiveness of technology for the future so that advanced countries such as United Sates and France have concerned about a next generation nuclear power plant, Gen-IV(Generation-IV Reactor). Considering various characteristics of nuclear R and D, it is necessary to have more elaborated strategies for the effective development of the next generation of nuclear technology. In this study, we suggest 5 key factors for the successful commercialization of Gen-IV by analyzing the distinct characteristics of nuclear R and D with Gen-IV and CSF(Critical Success Factor)s of several cases in these field and conducting the FGI(Focus Group Interview). Considering these results, we could find and suggest some important points for further strategy for Gen-IV. That is, following five key factors for the linkage improvement between R and D and commercialization of Gen-IV should be considered: the participation of nuclear power plant operators from the beginning, the establishment of consistent and comprehensive plan/roadmap/detailed strategy, the technology development based on global energy issues and international cooperation, the stable and clear funding plans for long-term projects, the cooperation of relative ministries. Gen-IV system is getting a positive response in that it accompanies long-term R and D plans in Korea. We think that the standard of Gen-IV would lead the next generation of nuclear industry if the proper strategy for the cooperation between the private sector and the regulation from the beginning. Moreover, we expect that this study will facilitate its development process from R and D to commercialization.

  2. Generation-IV nuclear reactors, SFR concept

    International Nuclear Information System (INIS)

    Dufour, P.

    2010-01-01

    In this presentation author deals with development of sodium-cooled fast reactors and lead-cooled fast reactors. He concluded that: - SFR is a proved concept that has never achieved industrial deployment; - The GEN IV objectives need to reconsider the design of both the core and the reactor design : innovations are being analysed; Future design will benefit from considerable feedback of design, licensing, construction and operation of PX, SPX, etc.

  3. Measuring Gen-Y Customer Experience in the Banking Sector

    Directory of Open Access Journals (Sweden)

    Kyguolienė Asta

    2017-12-01

    Full Text Available The article analyses customer experience as the subject of marketing research and presents methods for assessing customer experience. The results of empirical research revealing the Gen-Y customer experience in using the Lithuanian commercial banks’ services are presented.

  4. Nordic forum for generation IV reactors, status and activities in 2012

    International Nuclear Information System (INIS)

    Van Nieuwenhove, R.; Lauritzen, B.; Nonboel, E.

    2012-12-01

    The Nordic-Gen4 (continuation from NOMAGE4) seminar was this year hosted by DTU Nutech at Risoe, Denmark. The seminar was well attended (49 participants from 12 countries). The presentations covered many aspects in Gen-IV reactor research and gave a good overview of the activities within this field at the various institutes and universities. The present report contains book of abstracts. The individual Power Point presentations are indexed in INIS and may be found at http://nordic-gen4.org/seminars/nordic-gen4-riso-2012-2/ (LN)

  5. Nordic forum for generation IV reactors, status and activities in 2012

    Energy Technology Data Exchange (ETDEWEB)

    Van Nieuwenhove, R. [Institutt for Energiteknikk, OECD Halden Reactor Project, Kjeller (Norway); Lauritzen, B.; Nonboel, E. [Technical Univ. of Denmark. DTU Nutech, Roskilde (Denmark)

    2012-12-15

    The Nordic-Gen4 (continuation from NOMAGE4) seminar was this year hosted by DTU Nutech at Risoe, Denmark. The seminar was well attended (49 participants from 12 countries). The presentations covered many aspects in Gen-IV reactor research and gave a good overview of the activities within this field at the various institutes and universities. The present report contains book of abstracts. The individual Power Point presentations are indexed in INIS and may be found at http://nordic-gen4.org/seminars/nordic-gen4-riso-2012-2/ (LN)

  6. Best-practices guidelines for L2PSA development and applications. Volume 2 - Best practices for the Gen II PWR, Gen II BWR L2PSAs. Extension to Gen III reactors

    International Nuclear Information System (INIS)

    Raimond, E.; Durin, T.; Rahni, N.; Meignen, R.; Cranga, M.; Pichereau, F.; Bentaib, A.; Guigueno, Y.; Loeffler, H.; Mildenberger, O.; Lajtha, G.; Santamaria, C.S.; Dienstbier, J.; Rydl, A.; Holmberg, J.E.; Lindholm, I.; Maennistoe, I.; Pauli, E.M.; Dirksen, G.; Grindon, L.; Peers, K.; Hulqvist, G.; Parozzi, F.; Polidoro, F.; Cazzoli, E.; Vitazkova, J.; Burgazzi, L.; Oury, L.; Ngatchou, C.; Siltanen, S.; Niemela, I.; Routamo, T.; Helstroem, P.; Bassi, C.; Brinkman, H.; Seidel, A.; Schubert, B.; Wohlstein, R.; Guentay, S.; Vincon, L.

    2010-01-01

    The objective of this coordinated action was to develop best practice guidelines for the performance of Level 2 PSA methodologies with a view of harmonisation at EU level and to allow meaningful and practical uncertainty evaluations in a Level 2 PSA. Specific relationships with community in charge of nuclear reactor safety (utilities, safety authorities, vendors, and research or services companies) have been established in order to define the current needs in terms of guidelines for level 2 PSA development and applications. An international workshop was organised in Hamburg, with the support of VATTENFALL, in November 2008. The level 2 PSA experts from the ASAMPSA2 project partners have proposed some guidelines for the development and application of L2PSA based on their experience and on information available from international cooperation (EC Severe Accident network of Excellence - SARNET, IAEA standards, OECD-NEA publications and workshop) or open literature. The number of technical issues addressed in the guideline is very large and all are not covered with the same relevancy in the first version of the guideline. This version is submitted for external review in November 2010 by severe accident experts and PSA, especially, from SARNET and OECD-NEA members. The feedback of the external review will be dis cussed during an international open works hop planned in March 2011 and all outcomes will be taken into consideration in the final version of this guideline (June 2011). The guideline includes 3 volumes: - Volume 1 - General considerations on L2PSA. - Volume 2 - Technical recommendations for Gen II and III reactors. - Volume 3 - Specific considerations for future reactor (Gen IV). The recommendations formulated in the guideline should not be considered as 'mandatory' but should help the L2PSA developers to achieve high quality studies with limited time and resources. It may also help the L2PSA reviewers by positioning one specific study in comparison with some

  7. Asteroids IV

    Science.gov (United States)

    Michel, Patrick; DeMeo, Francesca E.; Bottke, William F.

    . Asteroids, like planets, are driven by a great variety of both dynamical and physical mechanisms. In fact, images sent back by space missions show a collection of small worlds whose characteristics seem designed to overthrow our preconceived notions. Given their wide range of sizes and surface compositions, it is clear that many formed in very different places and at different times within the solar nebula. These characteristics make them an exciting challenge for researchers who crave complex problems. The return of samples from these bodies may ultimately be needed to provide us with solutions. In the book Asteroids IV, the editors and authors have taken major strides in the long journey toward a much deeper understanding of our fascinating planetary ancestors. This book reviews major advances in 43 chapters that have been written and reviewed by a team of more than 200 international authorities in asteroids. It is aimed to be as comprehensive as possible while also remaining accessible to students and researchers who are interested in learning about these small but nonetheless important worlds. We hope this volume will serve as a leading reference on the topic of asteroids for the decade to come. We are deeply indebted to the many authors and referees for their tremendous efforts in helping us create Asteroids IV. We also thank the members of the Asteroids IV scientific organizing committee for helping us shape the structure and content of the book. The conference associated with the book, "Asteroids Comets Meteors 2014" held June 30-July 4, 2014, in Helsinki, Finland, did an outstanding job of demonstrating how much progress we have made in the field over the last decade. We are extremely grateful to our host Karri Muinonnen and his team. The editors are also grateful to the Asteroids IV production staff, namely Renée Dotson and her colleagues at the Lunar and Planetary Institute, for their efforts, their invaluable assistance, and their enthusiasm; they made life as

  8. Coordinator(a) de Servicios Clinicos. Parte I (Unidad I-IV). Parte II (Unidad V-VI). Guia. Documento de Trabajo (Clinical Services Coordinator. Part I. Units I-IV. Part II. Units V-VI. Guide. Working Document).

    Science.gov (United States)

    Puerto Rico State Dept. of Education, Hato Rey. Area for Vocational and Technical Education.

    This guide is intended for instructing secondary students in the occupation of clinical services coordinator in a hospital. The first part contains four units on the following subjects: the occupation of clinical services coordinator; interpersonal relationships; ethical/legal aspects; and communications (telephone, intercom, and others). For each…

  9. FutureGen Project Report

    Energy Technology Data Exchange (ETDEWEB)

    Cabe, Jim; Elliott, Mike

    2010-09-30

    This report summarizes the comprehensive siting, permitting, engineering, design, and costing activities completed by the FutureGen Industrial Alliance, the Department of Energy, and associated supporting subcontractors to develop a first of a kind near zero emissions integrated gasification combined cycle power plant and carbon capture and storage project (IGCC-CCS). With the goal to design, build, and reliably operate the first IGCC-CCS facility, FutureGen would have been the lowest emitting pulverized coal power plant in the world, while providing a timely and relevant basis for coal combustion power plants deploying carbon capture in the future. The content of this report summarizes key findings and results of applicable project evaluations; modeling, design, and engineering assessments; cost estimate reports; and schedule and risk mitigation from initiation of the FutureGen project through final flow sheet analyses including capital and operating reports completed under DOE award DE-FE0000587. This project report necessarily builds upon previously completed siting, design, and development work executed under DOE award DE-FC26- 06NT4207 which included the siting process; environmental permitting, compliance, and mitigation under the National Environmental Policy Act; and development of conceptual and design basis documentation for the FutureGen plant. For completeness, the report includes as attachments the siting and design basis documents, as well as the source documentation for the following: • Site evaluation and selection process and environmental characterization • Underground Injection Control (UIC) Permit Application including well design and subsurface modeling • FutureGen IGCC-CCS Design Basis Document • Process evaluations and technology selection via Illinois Clean Coal Review Board Technical Report • Process flow diagrams and heat/material balance for slurry-fed gasifier configuration • Process flow diagrams and heat/material balance

  10. Algoritmos genéticos locales

    OpenAIRE

    García-Martínez, Carlos; Lozano, Manuel

    2007-01-01

    Los Algoritmos Genéticos Locales son procedimientos que iterativamente re nan soluciones dadas. Su diferencia con procedimientos de mejora iterativa clásicos reside en el uso de operadores genéticos para realizar el re namiento. En este estudio presentamos un nuevo Algoritmo Genético Local Binario basado en un Algoritmo Genético Estacionario. Hemos comparado el Algoritmo Genético Local Binario con otros procedimientos de mejora iterativa de la literatura. Los res...

  11. DEVELOPMENT OF RISK-BASED AND TECHNOLOGY-INDEPENDENT SAFETY CRITERIA FOR GENERATION IV SYSTEMS

    Energy Technology Data Exchange (ETDEWEB)

    William E. Kastenberg; Edward Blandford; Lance Kim

    2009-03-31

    This project has developed quantitative safety goals for Generation IV (Gen IV) nuclear energy systems. These safety goals are risk based and technology independent. The foundations for a new approach to risk analysis has been developed, along with a new operational definition of risk. This project has furthered the current state-of-the-art by developing quantitative safety goals for both Gen IV reactors and for the overall Gen IV nuclear fuel cycle. The risk analysis approach developed will quantify performance measures, characterize uncertainty, and address a more comprehensive view of safety as it relates to the overall system. Appropriate safety criteria are necessary to manage risk in a prudent and cost-effective manner. This study is also important for government agencies responsible for managing, reviewing, and for approving advanced reactor systems because they are charged with assuring the health and safety of the public.

  12. DEVELOPMENT OF RISK-BASED AND TECHNOLOGY-INDEPENDENT SAFETY CRITERIA FOR GENERATION IV SYSTEMS

    International Nuclear Information System (INIS)

    Kastenberg, William E.; Blandford, Edward; Kim, Lance

    2009-01-01

    This project has developed quantitative safety goals for Generation IV (Gen IV) nuclear energy systems. These safety goals are risk based and technology independent. The foundations for a new approach to risk analysis has been developed, along with a new operational definition of risk. This project has furthered the current state-of-the-art by developing quantitative safety goals for both Gen IV reactors and for the overall Gen IV nuclear fuel cycle. The risk analysis approach developed will quantify performance measures, characterize uncertainty, and address a more comprehensive view of safety as it relates to the overall system. Appropriate safety criteria are necessary to manage risk in a prudent and cost-effective manner. This study is also important for government agencies responsible for managing, reviewing, and for approving advanced reactor systems because they are charged with assuring the health and safety of the public

  13. GenLab, Laboratorio Virtual de Genética

    Directory of Open Access Journals (Sweden)

    Fidel Ramírez

    2000-07-01

    Full Text Available GenLab es el nombre que tiene el software diseñado por nosotros, en el cual se modela el proceso meiótico y la fecundación en organismos diploides. El objetivo de esta aplicación es ilustrar el resultado de un cruce determinado, tratando de ser lo más ajustados a la realidad. La modelación de la reproducción sexual se realiza internamente y el GenLab se limita a presentar los resultados según el número de descendencia seleccionado para un cruce específico, esto significa que se puede escoger una gran cantidad de características para los parentales y se puede estudiar la frecuencia de estos en la descendencia. El modelo cuenta con base de datos donde están almacenados algunos de los locus de Drosophila melanogaster junto con su ubicación en centimorgans 1. EI propósito de este modelo es servir como herramienta pedagógica  y didáctica tanto en universidades como en colegios, facilitando el aprendizaje de algunos principios básicos de la genética, por lo cual puede ser usado si se cuenta con una conexión a Internet y un navegador visitando http://biologia.unal.edu.co/fidel.

  14. Taxonomic dissection of the genus Micrococcus: Kocuria gen. nov., Nesterenkonia gen. nov., Kytococcus gen. nov., Dermacoccus gen. nov., and Micrococcus Cohn 1872 gen. emend.

    Science.gov (United States)

    Stackebrandt, E; Koch, C; Gvozdiak, O; Schumann, P

    1995-10-01

    The results of a phylogenetic and chemotaxonomic analysis of the genus Micrococcus indicated that it is significantly heterogeneous. Except for Micrococcus lylae, no species groups phylogenetically with the type species of the genus, Micrococcus luteus. The other members of the genus form three separate phylogenetic lines which on the basis of chemotaxonomic properties can be assigned to four genera. These genera are the genus Kocuria gen. nov. for Micrococcus roseus, Micrococcus varians, and Micrococcus kristinae, described as Kocuria rosea comb. nov., Kocuria varians comb. nov., and Kocuria kristinae comb. nov., respectively; the genus Nesterenkonia gen. nov. for Micrococcus halobius, described as Nesterenkonia halobia comb. nov.; the genus Nesterenkonia gen. nov. for Micrococcus halobius, described as Nesterenkonia halobia comb. nov.; the genus Dermacoccus gen. nov. for Micrococcus nishinomiyaensis, described as Dermacoccus nishinomiyaensis comb. nov.; and the genus Kytocossus gen. nov. for Micrococcus sedentarius, described as Kytococcus sedentarius comb. nov. M. luteus and M. lylae, which are closely related phylogenetically but differ in some chemotaxonomic properties, are the only species that remain in the genus Micrococcus Cohn 1872. An emended description of the genus Micrococcus is given [corrected].

  15. The Long-Term Cost to the UK NHS and Social Services of Different Durations of IV Thiamine (Vitamin B1) for Chronic Alcohol Misusers with Symptoms of Wernicke's Encephalopathy Presenting at the Emergency Department.

    Science.gov (United States)

    Wilson, Edward C F; Stanley, George; Mirza, Zulfiquar

    2016-04-01

    Wernicke's encephalopathy (WE) is an acute neuropsychiatric condition caused by depleted intracellular thiamine, most commonly arising in chronic alcohol misusers, who may present to emergency departments (EDs) for a variety of reasons. Guidelines recommend a minimum 5-day course of intravenous (IV) thiamine in at-risk patients unless WE can be excluded. To estimate the cost impact on the UK public sector (NHS and social services) of a 5-day course of IV thiamine, vs a 2- and 10-day course, in harmful or dependent drinkers presenting to EDs. A Markov chain model compared expected prognosis of patients under alternative admission strategies over 35 years. Model inputs were derived from a prospective cohort study, expert opinion via structured elicitation and NHS costing databases. Costs (2012/2013 price year) were discounted at 3.5 %. Increasing treatment from 2 to 5 days increased acute care costs but reduced the probability of disease progression and thus reduced the expected net costs by GBP87,000 per patient (95 % confidence interval GBP19,300 to GBP172,300) over 35 years. Increasing length of stay to optimize IV thiamine replacement will place additional strain on acute care but has potential UK public sector cost savings. Social services and the NHS should explore collaborations to realise both the health benefits to patients and savings to the public purse.

  16. Nordic Nuclear Materials Forum for Generation IV Reactors

    International Nuclear Information System (INIS)

    Anghel, C.; Penttilae, S.

    2010-03-01

    A network for material issues for Generation IV nuclear power has been initiated within the Nordic countries. The objectives of the Generation IV Nordic Nuclear Materials Forum (NOMAGE4) are to put the basis of a sustainable forum for Gen IV issues, especially focussing on fuels, cladding, structural materials and coolant interaction. Other issues include reactor physics, dynamics and diagnostics, core and fuel design. The present report summarizes the work performed during the year 2009. The efforts made include identification of organisations involved in Gen IV issues in the Nordic countries, update of the forum website, http://www.studsvik.se/GenerationIV, and investigation of capabilities for research within the area of Gen IV. Within the NOMAGE4 project a seminar on Generation IV Nuclear Energy Systems has been organized during 15-16th of October 2009. The aim of the seminar was to provide a forum for exchange of information, discussion on future research needs and networking of experts on Generation IV reactor concepts. As an outcome of the NOMAGE4, a few collaboration project proposals have been prepared/planned in 2009. The network was welcomed by the European Commission and was mentioned as an exemplary network with representatives from industries, universities, power companies and research institutes. NOMAGE4 has been invited to participate to the 'European Energy Research Alliance, EERA, workshop for nuclear structural materials' http://www.eera-set.eu/index.php?index=41 as external observers. Future plans include a new Nordic application for continuation of NOMAGE4 network. (author)

  17. Nordic Nuclear Materials Forum for Generation IV Reactors

    Energy Technology Data Exchange (ETDEWEB)

    Anghel, C. (Studsvik Nuclear AB, Nykoeping (Sweden)); Penttilae, S. (Technical Research Centre of Finland, VTT (Finland))

    2010-03-15

    A network for material issues for Generation IV nuclear power has been initiated within the Nordic countries. The objectives of the Generation IV Nordic Nuclear Materials Forum (NOMAGE4) are to put the basis of a sustainable forum for Gen IV issues, especially focussing on fuels, cladding, structural materials and coolant interaction. Other issues include reactor physics, dynamics and diagnostics, core and fuel design. The present report summarizes the work performed during the year 2009. The efforts made include identification of organisations involved in Gen IV issues in the Nordic countries, update of the forum website, http://www.studsvik.se/GenerationIV, and investigation of capabilities for research within the area of Gen IV. Within the NOMAGE4 project a seminar on Generation IV Nuclear Energy Systems has been organized during 15-16th of October 2009. The aim of the seminar was to provide a forum for exchange of information, discussion on future research needs and networking of experts on Generation IV reactor concepts. As an outcome of the NOMAGE4, a few collaboration project proposals have been prepared/planned in 2009. The network was welcomed by the European Commission and was mentioned as an exemplary network with representatives from industries, universities, power companies and research institutes. NOMAGE4 has been invited to participate to the 'European Energy Research Alliance, EERA, workshop for nuclear structural materials' http://www.eera-set.eu/index.php?index=41 as external observers. Future plans include a new Nordic application for continuation of NOMAGE4 network. (author)

  18. Activities of the Service for maintenance of the RA reactor electronic equipment in 1979 - Report - Annex IV; Prilog IV Rad sluzbe za odrzavanje elektronske opreme reaktora RA u 1979. godini - Izvestaj -

    Energy Technology Data Exchange (ETDEWEB)

    Milosevic, M [Institute of Nuclear Sciences Boris Kidric, Vinca, Beograd (Serbia and Montenegro)

    1979-12-15

    Within the organizational structure of the RA reactor staff, the Service for instrumentation maintenance has the following tasks: maintenance of the existing electronic equipment; participating in experiments planning and preparation of electronic equipment; purchasing new equipment, spare parts and components; construction of new equipment for internal needs; implementation of new equipment. Basic instrumentation of the reactor facility includes: control and protection system, and dosimetry system. [Serbo-Croat] U okviru organizacione seme OOUR nuklearni reaktor RA sluzba za odrzavanje instrumentacije postrojenja ima sledece zadatke: odrzavanje postojece elektronske opreme; ucesce u planiranju eksperimenata i priprema elektronske opreme; nabavka nove opreme, rezervnih delova i komponenti; rad na izradi elektronske opreme i uredjaja za sopstvene potrebe i izrada projekata u domenu reaktorske opreme i ucesce u ugradnji nove opreme. Osnovna instrumentacija postrojenja obuhvata: sistem za upravljanje i zastitu, sistem za tehnolosku kontrolu i sistem za dozimetrijsku kontrolu.

  19. From AWE-GEN to AWE-GEN-2d: a high spatial and temporal resolution weather generator

    Science.gov (United States)

    Peleg, Nadav; Fatichi, Simone; Paschalis, Athanasios; Molnar, Peter; Burlando, Paolo

    2016-04-01

    A new weather generator, AWE-GEN-2d (Advanced WEather GENerator for 2-Dimension grid) is developed following the philosophy of combining physical and stochastic approaches to simulate meteorological variables at high spatial and temporal resolution (e.g. 2 km x 2 km and 5 min for precipitation and cloud cover and 100 m x 100 m and 1 h for other variables variable (temperature, solar radiation, vapor pressure, atmospheric pressure and near-surface wind). The model is suitable to investigate the impacts of climate variability, temporal and spatial resolutions of forcing on hydrological, ecological, agricultural and geomorphological impacts studies. Using appropriate parameterization the model can be used in the context of climate change. Here we present the model technical structure of AWE-GEN-2d, which is a substantial evolution of four preceding models (i) the hourly-point scale Advanced WEather GENerator (AWE-GEN) presented by Fatichi et al. (2011, Adv. Water Resour.) (ii) the Space-Time Realizations of Areal Precipitation (STREAP) model introduced by Paschalis et al. (2013, Water Resour. Res.), (iii) the High-Resolution Synoptically conditioned Weather Generator developed by Peleg and Morin (2014, Water Resour. Res.), and (iv) the Wind-field Interpolation by Non Divergent Schemes presented by Burlando et al. (2007, Boundary-Layer Meteorol.). The AWE-GEN-2d is relatively parsimonious in terms of computational demand and allows generating many stochastic realizations of current and projected climates in an efficient way. An example of model application and testing is presented with reference to a case study in the Wallis region, a complex orography terrain in the Swiss Alps.

  20. Current status of NPP generation IV

    International Nuclear Information System (INIS)

    Yohanes Dwi Anggoro; Dharu Dewi; Nurlaila; Arief Tris Yuliyanto

    2013-01-01

    Today development of nuclear technology has reached the stage of research and development of Generation IV nuclear power plants (advanced reactor systems) which is an innovative development from the previous generation of nuclear power plants. There are six types of power generation IV reactors, namely: Very High Temperature Reactor (VHTR), Sodium-cooled Fast Reactor (SFR), Gas-cooled Fast Reactor (GFR), Lead-cooled Fast Reactor (LFR), Molten Salt Reactor (MSR), and Super Critical Water-cooled Reactor (SCWR). The purpose of this study is to know the development of Generation IV nuclear power plants that have been done by the thirteen countries that are members of the Gen IV International Forum (GIF). The method used is review study and refers to various studies related to the current status of research and development of generation IV nuclear power. The result of this study showed that the systems and technology on Generation IV nuclear power plants offer significant advances in sustainability, safety and reliability, economics, and proliferation resistance and physical protection. In addition, based on the research and development experience is estimated that: SFR can be used optimally in 2015, VHTR in 2020, while NPP types GFR, LFR, MSR, and SCWR in 2025. Utilization of NPP generation IV said to be optimal if fulfill the goal of NPP generation IV, such as: capable to generate energy sustainability and promote long-term availability of nuclear fuel, minimize nuclear waste and reduce the long term stewardship burden, has an advantage in the field of safety and reliability compared to the previous generation of NPP and VHTR technology have a good prospects in Indonesia. (author)

  1. The generation IV nuclear reactor systems - Energy of future

    International Nuclear Information System (INIS)

    Ohai, Dumitru; Jianu, Adrian

    2006-01-01

    Ten nations joined within the Generation IV International Forum (GIF), agreeing on a framework for international cooperation in research. Their goal is to develop future-generation nuclear energy systems that can be licensed, constructed, and operated in an economically competitive way while addressing the issues of safety, proliferation, and other public perception concerns. The objective is for the Gen IV systems to be available for deployment by 2030. Using more than 100 nuclear experts from its 10 member nations, the GIF has developed a Gen IV Technology Roadmap to guide the research and development of the world's most advanced, efficient and safe nuclear power systems. The Gen IV Technology Roadmap calls for extensive research and development of six different potential future reactor systems. These include water-cooled, gas-cooled, liquid metal-cooled and nonclassical systems. One or more of these reactor systems will provide the best combination of safety, reliability, efficiency and proliferation resistance at a competitive cost. The main goals for the Gen IV Nuclear Energy Systems are: - Provide sustainable energy generation that meets clean air objectives and promotes long-term availability of systems and effective fuel use for worldwide energy production; - Minimize and manage their nuclear waste and noticeably reduce the long-term stewardship burden in the future, improving the protection of public health and the environment; - Increase the assurance that these reactors are very unattractive and the least desirable route for diversion or theft of weapons-usable materials, and provide increased protection against acts of terrorism; - Have a clear life-cycle cost advantage over other energy sources; - Have a level of financial risk comparable to other energy projects; - Excel in safety and reliability; - Have a low likelihood and degree of reactor core damage. (authors)

  2. Predictors of hospital stay and home care services use: a population-based, retrospective cohort study in stage IV gastric cancer.

    Science.gov (United States)

    Mahar, Alyson L; Coburn, Natalie G; Viola, Raymond; Johnson, Ana P

    2015-02-01

    Home care services use has been proposed as a means of reducing costs in palliative care by decreasing hospital stay without impacting quality of clinical care; however, little is known about utilization of these services in the time following a terminal cancer diagnosis. To examine disease, patient and healthcare system predictors of hospital stay, and home care services use in metastatic gastric cancer patients. This is a population-based, retrospective cohort study. Chart review and administrative data were linked, using a 26-month time horizon to collect health services data. All patients diagnosed with metastatic gastric cancer in the province of Ontario between 2005 and 2008 were included in the study (n = 1433). Age, comorbidity, tumor location, and burden of metastatic disease were identified as predictors of hospital stay and receipt of home care services. Individuals who received home care services spent fewer days in hospital than individuals who did not (relative risk: 0.44; 95% confidence interval: 0.38-0.51). Patients who interacted with a high-volume oncology specialist had shorter cumulative hospital stay (relative risk: 0.62; 95% confidence interval: 0.54-0.71) and were less likely to receive home care services (relative risk: 0.80; 95% confidence interval: 0.72-0.88) than those who did not. Examining how differences in hospital stay and home care services use impact clinical outcomes and how policies may reduce costs to the healthcare system is necessary. © The Author(s) 2014.

  3. Algoritmos genéticos

    Directory of Open Access Journals (Sweden)

    José Jesús Martínez Páez

    1998-10-01

    Full Text Available Esta técnica se basa en el concepto de evolución a través de selección de los mejores individuos, y de los operadores genéticos de selección, reproducción y mutación. Se trata entonces, de definir un espacio de soluciones para el problema que se quiere solucionar, en una cadena de bits. A esto se le conoce como la codificación del cromosoma, donde cada bit, denominado gen  tiene cierto significado especial. Inicialmente el algoritmo genera al azar muchas de estas cadenas o seres, es decir, una población, que luego confronta can un ambiente, que es el problema solucionar o función que se quiere optimizar. De esta confrontación  o evaluación a que se somete cada ser. Se obtiene información sobre cómo se comporto cada uno. A través de métodos aleatorios, pero con probabilidad de selección proporcional a su comportamiento, es decir, a mejor comportamiento mayor probabilidad, se selecciona una nueva población de seres supuestamente mejores que la generación anterior.

  4. IV treatment at home

    Science.gov (United States)

    ... Other IV treatments you may receive after you leave the hospital include: Treatment for hormone deficiencies Medicines for severe nausea that cancer chemotherapy or pregnancy may cause Patient-controlled analgesia (PCA) for pain (this is IV ...

  5. Genève Reconnaissante

    CERN Multimedia

    2001-01-01

    Robert Cailliau (centre), with Geneva's Mayor Alain Vaissade (left) and Jean Erhardt, Secretary General of the Administrative Council of Geneva (right). Geneva recognised the contribution of two CERN people to the reputation of the city last Tuesday when Mayor Alain Vaissade presented the Genève Reconaissante Medal to Tim Berners-Lee and Robert Cailliau. Berners-Lee, who was not able to be present in person, invented the World Wide Web at CERN just over a decade ago, while Cailliau was his first collaborator. Quoting Cailliau, Vaissade said that whilst there is no doubt that something like the Web would have appeared sooner or later, the fact that it happened at CERN, in Geneva, was no accident. Both the Laboratory and the city are places where people from around the world meet and work in harmony.

  6. The energy consumption of the services and farming sectors 1990 - 2035 - Results of scenarios I - IV; Der Energieverbrauch der Dienstleistungen und der Landwirtschaft, 1990 - 2035. Ergebnisse der Szenarien I bis IV und der zugehoerigen Sensitivitaeten BIP hoch, Preise hoch und Klima waermer

    Energy Technology Data Exchange (ETDEWEB)

    Aebischer, B.; Catenazzi, G.

    2007-07-01

    This comprehensive report for the Swiss Federal Office of Energy (SFOE) presents four scenarios concerning the development of energy consumption in the services sector and for farming for the period 1990 - 2035. The four scenarios - status quo, increased co-operation between the state and the economy with various levies, global reduction of energy consumption and, finally, scenario IV 'on the way to a 2000-Watt Society' - are briefly described. In particular, the scenarios are examined for various sensitivities: high gross domestic product GDP, CO{sub 2} levy, high prices and warmer climate. The models and methods used are examined and examples of their use are quoted. The results of the sensitivity analyses are compared and discussed and the necessary instruments are examined. This comprehensive report contains a large number of data-tables and graphical representations

  7. Report on generation IV technical working group 3 : liquid metal reactors

    International Nuclear Information System (INIS)

    Lineberry, M. J.; Rosen, S. L.; Sagayama, Y.

    2002-01-01

    This paper reports on the first round of R and D roadmap activities of the Generation IV (Gen IV) Technical Working Group (TWG) 3, on liquid metal-cooled reactors. Liquid metal coolants give rise to fast spectrum systems, and thus the reactor systems considered in this TWG are all fast reactors. Gas-cooled fast reactors are considered in the context of TWG 2. As is noted in other Gen IV papers, this first round activity is termed ''screening for potential'', and includes collecting the most complete set of liquid metal reactor/fuel cycle system concepts possible and evaluating the concepts against the Gen IV principles and goals. Those concepts or concept groups that meet the Gen IV principles and which are deemed to have reasonable potential to meet the Gen IV goals will pass to the next round of evaluation. Although we sometimes use the terms ''reactor'' or ''reactor system'' by themselves, the scope of the investigation by TWG 3 includes not only the reactor systems, but very importantly the closed fuel recycle system inevitably required by fast reactors. The response to the DOE Request for Information (RFI) on liquid metal reactor/fuel cycle systems from principal investigators, laboratories, corporations, and other institutions, was robust and gratifying. Thirty three liquid metal concept descriptions, from eight different countries, were ultimately received. The variation in the scope, depth, and completeness of the responses created a significant challenge for the group, but the TWG made a very significant effort not to screen out concepts early in the process

  8. Generating randomised virtualised scenarios for ethical hacking and computer security education: SecGen implementation and deployment

    OpenAIRE

    Schreuders, ZC; Ardern, L

    2015-01-01

    Computer security students benefit from having hands-on experience with hacking tools and with access to vulnerable systems that they can attack and defend. However, vulnerable VMs are static; once they have been exploited by a student there is no repeatable challenge as the vulnerable boxes never change. A new novel solution, SecGen, has been created and deployed. SecGen solves the issue by creating vulnerable machines with randomised vulnerabilities and services, with constraints that ensur...

  9. Generation IV national program

    International Nuclear Information System (INIS)

    Preville, M.; Sadhankar, R.; Brady, D.

    2007-01-01

    This paper outlines the Generation IV National Program. This program involves evolutionary and innovative design with significantly higher efficiencies (∼50% compared to present ∼30%) - sustainable, economical, safe, reliable and proliferation resistant - for future energy security. The Generation IV Forum (GIF) effectively leverages the resources of the participants to meet these goals. Ten countries signed the GIF Charter in 2001

  10. Unleashing Gen Y: Marketing Mars to Millennials

    Science.gov (United States)

    Leahy, Bart D.; Hidalgo, Loretta; Kloberdanz, Cassie

    2007-01-01

    Space advocates need to engage Generation Y (born 1977-1999).This outreach is necessary to recruit the next generation of scientists and engineers to explore Mars. Space advocates in the non-profit, private, and government sectors need to use a combination of technical communication, marketing, and politics, to develop messages that resonate with Gen Y. Until now, space messages have been generated by and for college-educated white males; Gen Y is much more diverse, including as much as one third minorities. Young women, too, need to be reached. My research has shown that messages emphasizing technology, fun, humor, and opportunity are the best means of reaching the Gen Y audience of 60 million (US population is 300 million). The important things space advocates must avoid are talking down to this generation, making false promises, or expecting them to "wait their turn" before they can participate. This is the MTV generation! We need to find ways of engaging Gen Y now to build a future where human beings can live and work on the planet Mars. In addition to the messages themselves, advocates need to keep up with Gen Y' s social networking and use of iPods, cell phones, and the Internet. NASA and space advocacy groups can use these tools for "viral marketing," where young people share targeted space-related information via cell phones or the Internet because they like it. Overall, Gen Y is a socially dynamic and media-savvy group; advocates' space messages need to be sincere, creative, and placed in locations where Gen Y lives. Mars messages must be memorable!

  11. Neptunium (IV) oxalate solubility

    International Nuclear Information System (INIS)

    Luerkens, D.W.

    1983-07-01

    The equilibrium solubility of neptunium (IV) oxalate in nitric/oxalic acid solutions was determined at 22 0 C, 45 0 C, and 60 0 C. The concentrations of nitric/oxalic acid solutions represented a wide range of free oxalate ion concentration. A mathematical solubility model was developed which is based on the formation of the known complexes of neptunium (IV) oxalate. the solubility model uses a simplified concentration parameter which is proportional to the free oxalate ion concentration. The solubility model can be used to estimate the equilibrium solubility of neptunium (IV) oxalate over a wide range of oxalic and nitric acid concentrations at each temperature

  12. Generation IV Reactors Integrated Materials Technology Program Plan: Focus on Very High Temperature Reactor Materials

    Energy Technology Data Exchange (ETDEWEB)

    Corwin, William R [ORNL; Burchell, Timothy D [ORNL; Katoh, Yutai [ORNL; McGreevy, Timothy E [ORNL; Nanstad, Randy K [ORNL; Ren, Weiju [ORNL; Snead, Lance Lewis [ORNL; Wilson, Dane F [ORNL

    2008-08-01

    Since 2002, the Department of Energy's (DOE's) Generation IV Nuclear Energy Systems (Gen IV) Program has addressed the research and development (R&D) necessary to support next-generation nuclear energy systems. The six most promising systems identified for next-generation nuclear energy are described within this roadmap. Two employ a thermal neutron spectrum with coolants and temperatures that enable hydrogen or electricity production with high efficiency (the Supercritical Water Reactor-SCWR and the Very High Temperature Reactor-VHTR). Three employ a fast neutron spectrum to enable more effective management of actinides through recycling of most components in the discharged fuel (the Gas-cooled Fast Reactor-GFR, the Lead-cooled Fast Reactor-LFR, and the Sodium-cooled Fast Reactor-SFR). The Molten Salt Reactor (MSR) employs a circulating liquid fuel mixture that offers considerable flexibility for recycling actinides and may provide an alternative to accelerator-driven systems. At the inception of DOE's Gen IV program, it was decided to significantly pursue five of the six concepts identified in the Gen IV roadmap to determine which of them was most appropriate to meet the needs of future U.S. nuclear power generation. In particular, evaluation of the highly efficient thermal SCWR and VHTR reactors was initiated primarily for energy production, and evaluation of the three fast reactor concepts, SFR, LFR, and GFR, was begun to assess viability for both energy production and their potential contribution to closing the fuel cycle. Within the Gen IV Program itself, only the VHTR class of reactors was selected for continued development. Hence, this document will address the multiple activities under the Gen IV program that contribute to the development of the VHTR. A few major technologies have been recognized by DOE as necessary to enable the deployment of the next generation of advanced nuclear reactors, including the development and qualification of

  13. SAGE IV Pathfinder

    Data.gov (United States)

    National Aeronautics and Space Administration — Utilizing a unique, new occultation technique involving imaging, the SAGE IV concept will meet or exceed the quality of previous SAGE measurements at a small...

  14. Description of Guyruita gen. nov. and two new species (Ischnocolinae, Theraphosidae Descrição de Guyruita gen. nov. e duas novas espécies (Ischnocolinae, Theraphosidae

    Directory of Open Access Journals (Sweden)

    José P.L. Guadanucci

    2007-12-01

    Full Text Available The genus Guyruita gen. nov. and two new species from Brazil are described. Holothele waikoshiemi (Bertani & Araújo, 2005 from Venezuela is transferred here to the new genus. Guyruita gen. nov. differs from the remaining Ischnocolinae by the following features: labium densely occupied by a lot of cuspules (more than 100, intercheliceral intumescence absent, posterior sternal sigilla remote from margin, tarsal claws without teeth, tarsal scopula I-II undivided (tarsus II with a line of sparse setae, which does not divide the scopula, III-IV divided.É descrito o gênero Guyruita gen. nov. e duas espécies novas do Brasil. Holothele waikoshiemi (Bertani & Araújo, 2005 da Venezuela é transferido para o novo gênero. Guyruita gen. nov. difere dos outros Ischnocolinae pelas seguintes caracterísicas: lábio densamente ocupado por muitas cúspides (mais de 100, tumescência interqueliceral ausente, sigilla esternal posterior distante da margem, unhas tarsais sem dentes, escópula tarsal I e II inteiras (tarso II com uma fileira de cerdas esparsas, as quais não dividem a escópula, III e IV divididas.

  15. Algoritmos para genómica comparativa

    OpenAIRE

    Figueiras, Vasco da Rocha

    2010-01-01

    Com o surgimento da Genómica e da Proteómica, a Bioinformática conduziu a alguns dos avanços científicos mais relevantes do século XX. A Unidade de Investigação e Desenvolvimento do Biocant, parque biotecnológico de Cantanhede, assume actualmente o papel de motor no desenvolvimento da Genómica. O Biocant possui um importante sequenciador de larga escala que permite armazenar um elevado número de genomas, nomeadamente, genomas de bactérias. O estudo proposto reflecte a necessidade do Bio...

  16. Services

    International Nuclear Information System (INIS)

    Hardeman, F.

    1998-01-01

    The objectives of the services section is (1) to offer complete services in health-physics measurements according to international quality standards, (2) to improve continuously these measurement techniques and to follow up international recommendations and legislation concerning the surveillance of workers, (3) to support and advise nuclear and non-nuclear industry on problems of radioactive contamination. Achievements related to gamma spectrometry, whole-body counting, beta and alpha spectrometry, dosimetry, radon measurements, calibration, instrumentation, and neutron activation analysis are described

  17. Preserving Accuracy in GenBank

    DEFF Research Database (Denmark)

    Bidartondo, M.I.; Bruns, T. D.; Blackwell, M.

    2008-01-01

    GenBank, the public repository for nucleotide and protein sequences, is a critical resource for molecular biology, evolutionary biology, and ecology. While some attention has been drawn to sequence errors (1), common annotation errors also reduce the value of this database. In fact, for organisms...

  18. Teleport Generation 3 (Teleport Gen 3)

    Science.gov (United States)

    2016-03-01

    for high- throughput multi-band and multimedia connectivity from deployed locations to DISN and DoD Information Network (DoDIN) information sources and...2016 Major Automated Information System Annual Report Teleport Generation 3 (Teleport Gen 3) Defense Acquisition Management Information Retrieval...Program Information 4 Responsible Office 4 References 4 Program Description 5 Business Case 6 Program Status 8 Schedule 9

  19. Telecommunications Relay Services

    Science.gov (United States)

    ... Home » Health Info » Hearing, Ear Infections, and Deafness Telecommunications Relay Services On this page: What are telecommunication ... additional information about telecommunication relay services? What are telecommunication relay services? Title IV of the Americans with ...

  20. Divergência genética entre genótipos de frangos tipo caipira

    Directory of Open Access Journals (Sweden)

    R. C. Veloso

    2015-10-01

    Full Text Available RESUMOObjetivou-se com este trabalho verificar a divergência genética entre sete genótipos de frangos tipo caipira da linhagem Redbro utilizando as características de desempenho por meio de técnicas de análise multivariada. Foram utilizados 840 pintos de um dia, machos, distribuídos em delineamento inteiramente ao acaso, dos seguintes genótipos: Caboclo, Carijó, Colorpak, Gigante Negro, Pesadão Vermelho, Pescoço Pelado e Tricolor. Após a consistência dos dados, foram avaliadas as seguintes variáveis: ganho em peso médio diário, consumo de ração médio diário e conversão alimentar, para os períodos: 1 a 28, 1 a 56, 1 a 70 e 1 a 84 dias de idade; peso corporal ao nascimento, aos 28, 56, 70 e aos 84 dias de idade. O desempenho dos genótipos foi avaliado por meio da análise de variância multivariada e da função discriminante linear de Fisher, usando os testes do maior autovalor de Roy e da união-interseção de Roy para as comparações múltiplas. O estudo da divergência genética foi feito por meio da análise por variáveis canônicas e pelo método de otimização de Tocher. Os genótipos Caboclo e Gigante Negro apresentaram médias canônicas diferentes dos demais genótipos. As duas primeiras variáveis canônicas explicaram 97,41% da variação entre os genótipos. A divergência genética entre os genótipos avaliados permitiu a formação de quatro grupos com os seguintes genótipos: grupo 1 - Colorpak; grupo 2 - Pesadão Vermelho e Pescoço Pelado; grupo 3 - Carijó e Tricolor; e grupo 4 - Caboclo e Gigante Negro.

  1. Next Gen One Portal Usability Evaluation

    Science.gov (United States)

    Cross, E. V., III; Perera, J. S.; Hanson, A. M.; English, K.; Vu, L.; Amonette, W.

    2018-01-01

    Each exercise device on the International Space Station (ISS) has a unique, customized software system interface with unique layouts / hierarchy, and operational principles that require significant crew training. Furthermore, the software programs are not adaptable and provide no real-time feedback or motivation to enhance the exercise experience and/or prevent injuries. Additionally, the graphical user interfaces (GUI) of these systems present information through multiple layers resulting in difficulty navigating to the desired screens and functions. These limitations of current exercise device GUI's lead to increased crew time spent on initiating, loading, performing exercises, logging data and exiting the system. To address these limitations a Next Generation One Portal (NextGen One Portal) Crew Countermeasure System (CMS) was developed, which utilizes the latest industry guidelines in GUI designs to provide an intuitive ease of use approach (i.e., 80% of the functionality gained within 5-10 minutes of initial use without/limited formal training required). This is accomplished by providing a consistent interface using common software to reduce crew training, increase efficiency & user satisfaction while also reducing development & maintenance costs. Results from the usability evaluations showed the NextGen One Portal UI having greater efficiency, learnability, memorability, usability and overall user experience than the current Advanced Resistive Exercise Device (ARED) UI used by astronauts on ISS. Specifically, the design of the One-Portal UI as an app interface similar to those found on the Apple and Google's App Store, assisted many of the participants in grasping the concepts of the interface with minimum training. Although the NextGen One-Portal UI was shown to be an overall better interface, observations by the test facilitators noted specific exercise tasks appeared to have a significant impact on the NextGen One-Portal UI efficiency. Future updates to

  2. The European gen-set market: growth and consolidation mean joy and pain

    International Nuclear Information System (INIS)

    French, Ian

    2000-01-01

    The changes in the European gen-set market are discussed. In recent years the market has undergone a period of increasing consolidation: prices fell and some companies folded. However, the market is not dead and continued growth is expected over the next five years although the compound rate is forecast to be only 1.5%. The article is presented under the sub-headings of (i) current market situation; (ii) product lifecycle; (iii) shipments by technology; (iv) market deregulation; (v) technology overview (spark ignition, compression ignition and gas turbines) (vi) European market: national overview and (vii) key market challenges (competition, emissions and over capacity)

  3. IV access in dental practice.

    LENUS (Irish Health Repository)

    Fitzpatrick, J J

    2009-04-01

    Intravenous (IV) access is a valuable skill for dental practitioners in emergency situations and in IV sedation. However, many people feel some apprehension about performing this procedure. This article explains the basic principles behind IV access, and the relevant anatomy and physiology, as well as giving a step-by-step guide to placing an IV cannula.

  4. Generation IV Nuclear Energy Systems Construction Cost Reductions through the Use of Virtual Environments - Task 5 Report: Generation IV Reactor Virtual Mockup Proof-of-Principle Study

    International Nuclear Information System (INIS)

    Timothy Shaw; Anthony Baratta; Vaughn Whisker

    2005-01-01

    Task 5 report is part of a 3 year DOE NERI-sponsored effort evaluating immersive virtual reality (CAVE) technology for design review, construction planning, and maintenance planning and training for next generation nuclear power plants. Program covers development of full-scale virtual mockups generated from 3D CAD data presented in a CAVE visualization facility. Created a virtual mockup of PBMR reactor cavity and discussed applications of virtual mockup technology to improve Gen IV design review, construction planning, and maintenance planning

  5. Generation IV Nuclear Energy Systems Construction Cost Reductions through the Use of Virtual Environments - Task 5 Report: Generation IV Reactor Virtual Mockup Proof-of-Principle Study

    Energy Technology Data Exchange (ETDEWEB)

    Timothy Shaw; Anthony Baratta; Vaughn Whisker

    2005-02-28

    Task 5 report is part of a 3 year DOE NERI-sponsored effort evaluating immersive virtual reality (CAVE) technology for design review, construction planning, and maintenance planning and training for next generation nuclear power plants. Program covers development of full-scale virtual mockups generated from 3D CAD data presented in a CAVE visualization facility. Created a virtual mockup of PBMR reactor cavity and discussed applications of virtual mockup technology to improve Gen IV design review, construction planning, and maintenance planning.

  6. Uranium (IV) carboxylates - I

    Energy Technology Data Exchange (ETDEWEB)

    Satpathy, K C; Patnaik, A K [Sambalpur Univ. (India). Dept. of Chemistry

    1975-11-01

    A few uranium(IV) carboxylates with monochloro and trichloro acetic acid, glycine, malic, citric, adipic, o-toluic, anthranilic and salicylic acids have been prepared by photolytic methods. The I.R. spectra of these compounds are recorded and basing on the spectral data, structure of the compounds have been suggested.

  7. PLATO IV Accountancy Index.

    Science.gov (United States)

    Pondy, Dorothy, Comp.

    The catalog was compiled to assist instructors in planning community college and university curricula using the 48 computer-assisted accountancy lessons available on PLATO IV (Programmed Logic for Automatic Teaching Operation) for first semester accounting courses. It contains information on lesson access, lists of acceptable abbreviations for…

  8. A Study on the Planning of Technology Development and Research for Generation IV Nuclear Energy Systems

    Energy Technology Data Exchange (ETDEWEB)

    Chang, Moon Hee; Kim, H. R.; Kim, H. J. and others

    2005-08-15

    This study aimed at the planning the domestic technology development of the Gen IV and the formulating the international collaborative project contents and executive plan for 'A Validity Assessment and Policies of the R and D of Generation IV Nuclear Energy Systems'. The results of the study include follows; - Survey of the technology state in the fields of the Gen IV system specific technologies and the common technologies, and the plans of the international collaborative research - Drawing up the executive research and development plan by the experts of the relevant technology field for the systems which Korean will participate in. - Formulating the effective conduction plan of the program reflecting the view of the experts from the industry, the university and the research institute. - Establishing the plan for estimation of the research fund and the manpower for the efficient utilization of the domestic available resources. This study can be useful material for evaluating the appropriateness of the Korea's participation in the international collaborative development of the Gen IV, and can be valuably utilized to establish the strategy for the effective conduction of the program. The executive plan of the research and development which was produced in this study will be used to the basic materials for the establishing the guiding direction and the strategic conduction of the program when the research and development is launched in the future.

  9. Genética humana e sociedade

    OpenAIRE

    Rosa, Vivian Leyser da

    2000-01-01

    Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências da Educação. Análise do campo de estudos sobre o entendimento público da ciência, distinguindo os modelos de deficit cognitivo e interativo, bem como suas implicações na esfera educacional. Estudo do panorama dos avanços atuais da genética humana, do ponto de vista científico, ético e social. Análise de aspectos relativos ao ensino de genética humana nos cursos de graduação da área da saúde, em nove Universidades...

  10. Project planning of Gen-IV sodium cooled fast reactor technology

    International Nuclear Information System (INIS)

    Yoo, Jaewoon; Joo, H. K.; Cho, C. H.; Kim, Y. G.; Lee, D. U.; Jin, M. W.

    2013-05-01

    The project program will be established to shorten the design schedule by sharing the design man power and experimental facility, and by introducing the proven technology through international collaboration and the project plan including preliminary specific design, technology validation and fuel design validation plan will be more detail by reviewing the plan at the International Technical Review Meeting (ITRM). Periodic project progress review meeting will be held to find the technical issues and to resolve them. The results of the progress review meeting will be reflected into the final assessment of research project. The project progress review meeting will be held every quarter and external expert will also participate in the meeting. In parallel with the PGSFR development, innovative small modular SFR will be developed aiming to the international nuclear market. The system and component technologies of both system can be shared but innovative concept will be implemented into the design. Ultra long life core design concept and supercritical CO 2 Brayton cycle will be considered as the innovative concept for enhancing the plant economy and safety

  11. Database of thermophysical properties of liquid metal coolants for GEN-IV

    International Nuclear Information System (INIS)

    Sobolev, V.

    2011-01-01

    The report presents an Fe-Cr interatomic potential to model high-Cr ferritic alloys. The potential is fitted to thermodynamic and point-defect properties obtained from density functional theory (DFT) calculations and experiments. The developed potential is also benchmarked against other potentials available in literature. It shows particularly good agreement with the DFT obtained mixing enthalpy of the random alloy, the formation energy of intermetallics and experimental excess vibrational entropy and phase diagram. In addition, DFT calculated point-defect properties, both interstitial and substitutional, are well reproduced, as is the screw dislocation core structure. As a first validation of the potential, we study the precipitation hardening of Fe-Cr alloys via static simulations of the interaction between Cr precipitates and screw dislocations. It is concluded that the description of the dislocation core modification near a precipitate might have a significant influence on the interaction mechanisms observed in dynamic simulations.

  12. GEN IV: Carbide Fuel Elaboration for the 'Futurix Concepts' experiment

    Energy Technology Data Exchange (ETDEWEB)

    Vaudez, Stephane; Riglet-Martial, Chantal; Paret, Laurent; Abonneau, Eric [Commissariat a l' Energie Atomique (C.E.A.), Direction de l' Energie Nucleaire, Centre d' Etudes de Cadarache, 13108 Saint Paul lez Durance Cedex (France)

    2008-07-01

    In order to collect information on the behaviour of the future GFR (Gas Fast Reactor) fuel under fast neutron irradiation, an experimental irradiation program, called 'Futurix-concepts' has been launched at the CEA. The considered concept is a composite material made of a fissile fuel embedded in an inert ceramic matrix. Fissile fuel pellets are made of UPuN or UPuC while ceramics are SiC for the carbide fuel and TiN for the nitride fuel. This paper focuses on the description of the carbide composite fabrication. The UPuC pellets are manufactured using a metallurgical powder process. Fabrication and handling of the fuels are carried out in glove boxes under a nitrogen atmosphere. Carbide fuel is synthesized by carbo-thermic reduction under vacuum of a mixture of actinide oxide and graphitic carbon up to 1550 deg. C. After ball milling, the UPuC powder is pressed to create hexagonal or spherical compacts. They are then sintered up to 1750 deg. C in order to obtain a density of 85 % of the theoretical one. The sintered pellets are inserted into an inert and tight capsule of SiC. In order to control the gap between the fuel and the matrix precisely, the pellets are abraded. The inert matrix is then filled with the pellets and the whole system is sealed by a BRASiC{sup R} process at high temperature under a helium atmosphere. Fabrication of the sample to be irradiated was done in 2006 and the irradiation began in May 2007 in the Phenix reactor. This presentation will detail and discuss the results obtained during this fabrication phase. (authors)

  13. Millimeter-Wave Thermal Analysis Development and Application to GEN IV Reactor Materials

    Energy Technology Data Exchange (ETDEWEB)

    Wosko, Paul; Sundram, S. K.

    2012-10-16

    New millimeter-wave thermal analysis instrumentation has been developed and studied for characterization of materials required for diverse fuel and structural needs in high temperature reactor environments such as the Next Generation Nuclear Plant (NGNP). A two-receiver 137 GHz system with orthogonal polarizations for anisotropic resolution of material properties has been implemented at MIT. The system was tested with graphite and silicon carbide specimens at temperatures up to 1300 ºC inside an electric furnace. The analytic and hardware basis for active millimeter-wave radiometry of reactor materials at high temperature has been established. Real-time, non contact measurement sensitivity to anisotropic surface emissivity and submillimeter surface displacement was demonstrated. The 137 GHz emissivity of reactor grade graphite (NBG17) from SGL Group was found to be low, ~ 5 %, in the 500 – 1200 °C range and increases by a factor of 2 to 4 with small linear grooves simulating fracturing. The low graphite emissivity would make millimeter-wave active radiometry a sensitive diagnostic of graphite changes due to environmentally induced stress fracturing, swelling, or corrosion. The silicon carbide tested from Ortek, Inc. was found to have a much higher emissivity at 137 GHz of ~90% Thin coatings of silicon carbide on reactor grade graphite supplied by SGL Group were found to be mostly transparent to millimeter-waves, increasing the 137 GHz emissivity of the coated reactor grade graphite to about ~14% at 1250 ºC.

  14. Project planning of Gen-IV sodium cooled fast reactor technology

    Energy Technology Data Exchange (ETDEWEB)

    Yoo, Jaewoon; Joo, H. K.; Cho, C. H.; Kim, Y. G.; Lee, D. U.; Jin, M. W.

    2013-05-15

    The project program will be established to shorten the design schedule by sharing the design man power and experimental facility, and by introducing the proven technology through international collaboration and the project plan including preliminary specific design, technology validation and fuel design validation plan will be more detail by reviewing the plan at the International Technical Review Meeting (ITRM). Periodic project progress review meeting will be held to find the technical issues and to resolve them. The results of the progress review meeting will be reflected into the final assessment of research project. The project progress review meeting will be held every quarter and external expert will also participate in the meeting. In parallel with the PGSFR development, innovative small modular SFR will be developed aiming to the international nuclear market. The system and component technologies of both system can be shared but innovative concept will be implemented into the design. Ultra long life core design concept and supercritical CO{sub 2} Brayton cycle will be considered as the innovative concept for enhancing the plant economy and safety.

  15. Control Rod Withdrawal Events Analyses for the Prototype Gen-IV SFR

    Energy Technology Data Exchange (ETDEWEB)

    Choi, Chiwoong; Ha, Kwiseo; Jeong, Taekyeong; Jeong, Jaeho; Chang, Wonpyo; Lee, Seungwon; An, Sangjun; Lee, Kwilim [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2016-10-15

    To confirm the limiting condition, based on the maximum allowable reactivity insertion of 0.3 $, three cases from the end of cycle (EOC) are selected. In addition, assuming the failure of CRSS by earthquake, additional cases is defined at beginning of cycle (BOC). When the CRW occurs, the reactor can be protected by plant protection system (PPS). In this study, PPS mechanism is sequentially studied for all initiating events. For design basis accidents (DBA), the reactor can be scrammed by reactor protection system (RPS). The first and seconds RPS signals are checked during transients. When RPS is failed, so called as anticipated transient without scram (ATWS), the reactor will be protected by diverse protection system (DPS). In this study, in order to analyze various initiating events related control rod withdrawal, four kinds of operating condition is defined. TOP events are analyzed using MARS-LMR. The influence of various plant protection system such as RPS and DPS are investigated.

  16. Electromagnet Response Time Tests on Primary CRDM of a Prototype Gen-IV SFR

    International Nuclear Information System (INIS)

    Lee, Jae-Han; Koo, Gyeong-Hoi

    2015-01-01

    This paper identifies the electromagnetic response characteristics of the electromagnet of a primary control rod drive mechanism (CRDM) used for the reactor scram function. The test measures the electromagnet response time required to release an armature from a stator controlled by a loss of an electromagnetic force on an armature after shorting a power supply to an electromagnet coil. These tests are carried out while changing the electromagnet core material, an assist spring, and an armature holding current. The main factors influencing the test parameters on the response are found to be the armature holding current for holding the armature loads, and the material type of the electromagnet cores. The minimum response time is 0.13 seconds in the case of using SS410 material as an armature, while the S10C material as an armature has a response time of 0.21 seconds. Electromagnet response time characteristics from the test results will be evaluated by comparing the precise moving data of an electromagnet armature through the use of a high-speed camera and a potentiometer in the future

  17. Tritium Sequestration in Gen IV NGNP Gas Stream via Proton Conducting Ceramic Pumps

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Fanglin Frank [Univ. of South Carolina, Columbia, SC (United States); Adams, Thad M. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL); Brinkman, Kyle [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL); Reifsnider, Kenneth [Univ. of South Carolina, Columbia, SC (United States)

    2011-09-30

    Several types of high-temperature proton conductors based on SrCeO3 and BaCeO3 have been systematically investigated in this project for tritium separation in NGNP applications. One obstacle for the field application is the chemical stability issues in the presence of steam and CO2 for these proton conductors. Several strategies to overcome such issues have been evaluated, including A site doping and B site co-doping method for perovskite-structured proton conductors. Novel zirconium-free proton conductors have also been developed with improved electrical conductivity and enhanced chemical stability. Novel catalytic materials for the proton-conducting separation membranes have been investigated. A tubular geometry proton-conducting membrane has been developed for the proton separation membranes. Total dose rate estimated from tritium decay (beta emission) under realistic membrane operating conditions, combined with electron irradiation experiments, indicates that proton ceramic materials possess the appropriate radiation stability for this application.

  18. Studies on woloszynskioid dinoflagellates IV: the genus Biecheleria gen. nov

    DEFF Research Database (Denmark)

    Moestrup, Øjvind; Lindberg, Karin; Daugbjerg, Niels

    2009-01-01

    in the dinoflagellates. Biecheleria also comprises the brackish water species Biecheleria baltica sp. nov. (presently identified as Woloszynskia halophila) and the marine species Biecheleria natalensis (syn. Gymnodinium natalense). Gymnodinium halophilum described in 1952 by B. Biecheler but apparently not subsequently...... refound, is transferred to Biecheleria. The Suessiaceae further includes the marine species Protodinium simplex, described by Lohmann in 1908 but shortly afterwards (1921) transferred to Gymnodinium by Kofoid and Swezy and subsequently known as Gymnodinium simplex. It only distantly related to Gymnodinium...

  19. Analyses of Design Extended Condition Events for the Prototype Gen-IV SFR

    International Nuclear Information System (INIS)

    Choi, Chiwoong; Jeong, Taekyung; Lee, Kwilim; Jeong, Jaeho; Ha, Kwiseok

    2015-01-01

    In this study, the sensitivity tests are conducted. In the case of the UTOP event, a sensitivity test for the reactivity insertion amount and rate were conducted. This analysis can give a requirement for margin of control rod stop system (CRSS). For example, the CRSS in the PRISM designed based on the 0.4 $ reactivity insertion, which is analyzed with safety analysis of UTOP event. Moreover, the sensitivity tests for weighting factor in the core radial expansion reactivity feedback model were also carried out for all ATWS events. Currently, the reactivity feedback model for the PGSFR is not validated yet. However, the reactivity feedback models in the MARS-LMR are validating with various plant-based data including EBR-II SHRT. The ATWS events for the PGSFR classified in the design extended condition including UTOP, ULOF, and ULOHS are analyzed with MARS-LMR. In this study, the sensitivity tests for reactivity insertion amount and rate in the UTOP event are conducted. The reactivity insertion amount is obviously an influential parameter. The reactivity insertion amount can give a requirement for design of the CRSS, therefore, this sensitivity result is very important to the CRSS. In addition, sensitivity tests for the weighting factor in the radial expansion reactivity model are carried out. The weighting factor for a grid plate, W GP , which means contribution of feedback in the grid plate is changed for all unprotected events. The grid plate expansion is governed by a core inlet temperature. As the W GP is increased, the power in the UTOP and the ULOF is increased, however, the power in the ULOHS is decreased. The higher power during transient means lower reactivity feedback and smaller expansion. Thus, the core outlet temperature rise is dominant in the UTOP and ULOF events, however, the core inlet temperature rise is dominant in the ULOHS. Therefore, the grid plate expansion in the ULOHS is predominant

  20. Training Courses in Support of GEN-IV Development – The Case of SVBR Technology

    International Nuclear Information System (INIS)

    Kondaurov, A.; Zaitseva, N.; Yunikova, A.; Artisiuk, V.

    2014-01-01

    Conclusions: For prototype nuclear power reactor the development of training materials requires high level expertise from the R&D side. The First International Course focusing the SVBR technology was developed and piloted in ROSATOM Central Institute for Continuing Education&Training to support HRD for Open Joint-Stock Company «AKME-engineering» - owner and operator of SVBR-100. The Course is available for international participants

  1. Minor actinides transmutation potential: state of art for GEN IV sodium cooled fast reactors

    International Nuclear Information System (INIS)

    Buiron, Laurent

    2015-01-01

    In the frame of the R and D program relative to the 1991 French act on nuclear waste management, fast neutron systems have shown relevant characteristics that meet both requirements on sustainable resources management and waste minimization. They also offer flexibility by mean of burner or breeder configurations allowing mastering plutonium inventory without significant impact on core safety. From the technological point of view, sodium cooled fast reactor are considered in order to achieve mean term industrial deployment. The present document summaries the main results of R and D program on minor actinides transmutation in sodium fast reactor since 2006 following recommendation of the first part of the 1991 French act. Both homogeneous and heterogeneous management achievable performances are presented for 'evolutionary' SFR V2B core as well as low void worth CFV core for industrial scale configurations (1500 MWe). Minor actinides transmutation could be demonstrated in the ASTRID reactor with the following configurations: - a 2%vol Americium content for the homogeneous mode, - a 10%vol Americium content for the heterogeneous mode, without any substantial modification of the main core safety parameters and only limited impacts on the associated fuel cycle (manufacturing issues are not considered here). In order to achieve such goal, a wide range of experimental irradiations driven by transmutation scenarios have to be performed for both homogeneous and heterogeneous minor actinides management. (author) [fr

  2. Tritium Sequestration in Gen IV NGNP Gas Stream via Proton Conducting Ceramic Pumps

    International Nuclear Information System (INIS)

    Chen, Franglin Frank; Adams, Thad M.; Brinkman, Kyle; Reifsnider, Kenneth

    2011-01-01

    Several perovskite structured proton conductors based on SrCeO 3 and BaCeO 3 have been investigated in the project. The solid solutions for SrCeO 3 and BaCeO 3 were first investigated. The morphological and electrical properties of Ba 1-x Sr x Ce 0.8 Y 0.2 O 3-δ with x varying from 0 to 1 prepared by a modified Pechini method were investigated as potential high temperature proton conductors. Dense microstructures were achieved for all the samples upon sintering at 1500ees)C for 5 h. The phase structure analysis indicated that perovskite phase was formed for 0≤x≤0.2, while for x larger than 0.5, impurity phases of Sr 2 CeO 4 and Y 2 O 3 appeared. The stability tests indicated that the resistance to boiling water for Ba 1-x Sr x Ce 0.8 Y 0.2 O 3-δ was between that of BaCe 0.8 Y 0.2 O 3-δ and SrCe 0.8 Y 0.2 O 3-δ Due to the tendency of the reaction with CO 2 for both BaCe 0.8 Y 0.2 O 3-δ and SrCe 0.8 Y 0.2 O 3-δ , it was not surprising that Ba 1-x Sr x Ce 0.8 Y 0.2 O 3-δ was also not stable in CO 2 containing atmospheres. The conductivity tests indicated that Ba 1-x Sr x Ce 0.8 Y 0.2 O 3-δ possessed the electrical conductivity between BaCe 0.8 Y 0.2 O 3-δ and SrCe 0.8 Y 0.2 O 3-δ . The conductivity decreased and the activation energy increased with the increase in Sr content in Ba 1-x Sr x Ce 0.8 Y 0.2 O 3-δ .

  3. Preliminary Comparative Evaluation Study on Reference Design of GEN-IV SFR

    Energy Technology Data Exchange (ETDEWEB)

    Sim, Yoon Sub; Kim, Yeong Il; Hong, Ser Gi (and others)

    2005-11-15

    A fast reactor has a good transmutation capability and it enables breeding of fuel and use of a closed fuel cycle. By these characteristics of a fast reactor, the limited uranium resources of the world can be much more effectively utilized and the nuclear wastes of a high level of radioactivity and toxicity from the current nuclear power reactors of LWRs and HWRs can be drastically reduced in its volume and the management of the wastes can be easily treated. Also electricity can be generated more effectively since a fast reactor has the feature of high operation temperature. These features of a fast reactor makes it inevitable on a long term basis to construct fast reactors in Korea. The domestic fast reactor technology level, however, is at the level of coming out of a beginning stage and needs utilization of international expertise. Recently an international cooperation program called GIF has been formulated and our KALIMER was selected as one of the two reference designs for the international joint R and D works with JSFR of Japan. In the current frame of the GIF program, the two selected reference designs are supposed to be evaluated against each other in future and one design is to be finally selected. To make the international cooperation program directed more useful to our fast reactor technology development, it is required to strengthen the competitiveness of KALIMER so that it can be selected. To meet the necessity, a study was made in this research for pre-evaluation of the GIF reference designs and setting up plans for development of designs and technology that will enhance the competitiveness of KALIMER.

  4. Sensitivity Tests for the Unprotected Events of the Prototype Gen-IV SFR

    Energy Technology Data Exchange (ETDEWEB)

    Choi, Chiwoong; Lee, Kwilim; Jeong, Jaeho; Yu, Jin; An, Sangjun; Lee, Seung Won; Chang, Wonpyo; Ha, Kwiseok [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2014-10-15

    Unprotected Transient Over Power, (UTOP), Unprotected Loss Of Flow (ULOF), and Unprotected Loss Of Heat Sink (ULOHS) are selected as ATWS events. Among these accidents, the ULOF event shows the lowest clad temperature. However, the ULOHS event showed the highest peak clad temperature, due to the positive CRDL/RV expansion reactivity feedback and insufficient DHRS capacity. In this study, the sensitivity tests are conducted. In the case of the UTOP event, a sensitivity test for the reactivity insertion amount and rate were conducted. This analysis can give a requirement for margin of control rod stop system (CRSS). Currently, the reactivity feedback model for the PGSFR is not validated yet. However, the reactivity feedback models in the MARS-LMR are validating with various plant-based data including EBR-II SHRT. The ATWS events for the PGSFR classified in the design extended condition including UTOP, ULOF, and ULOHS are analyzed with MARS-LMR. In this study, the sensitivity tests for reactivity insertion amount and rate in the UTOP event are conducted. The reactivity insertion amount is obviously an influential parameter. The reactivity insertion amount can give a requirement for design of the CRSS, therefore, this sensitivity result is very important to the CRSS. In addition, sensitivity tests for the weighting factor in the radial expansion reactivity model are carried out. The weighting factor for a grid plate, W{sub GP}, which means contribution of feedback in the grid plate is changed for all unprotected events. The grid plate expansion is governed by a core inlet temperature. As the W{sub GP} is increased, the power in the UTOP and the ULOF is increased, however, the power in the ULOHS is decreased. The higher power during transient means lower reactivity feedback and smaller expansion. Thus, the core outlet temperature rise is dominant in the UTOP and ULOF events, however, the core inlet temperature rise is dominant in the ULOHS. Therefore, the grid plate expansion in the ULOHS is predominant. These analysis results will give better understanding for the unprotected events and provide feedback to design for the PGSFR. In addition, the safety analyses for unprotected events: UTOP, ULOF, and ULOHS will be recalculated with CDF, which is a safety criteria in the near future.

  5. Enhanced Design Alternative IV

    International Nuclear Information System (INIS)

    Kramer, N.E.

    1999-01-01

    This report evaluates Enhanced Design Alternative (EDA) IV as part of the second phase of the License Application Design Selection (LADS) effort. The EDA IV concept was compared to the VA reference design using criteria from the Design Input Request for LADS Phase II EDA Evaluations (CRWMS M and O 1999b) and (CRWMS M and O 1999f). Briefly, the EDA IV concept arranges the waste packages close together in an emplacement configuration known as line load. Continuous pre-closure ventilation keeps the waste packages from exceeding their 350 C cladding and 200 C (4.3.6) drift wall temperature limits. This EDA concept keeps relatively high, uniform emplacement drift temperatures (post-closure) to drive water away from the repository and thus dry out the pillars between emplacement drifts. The waste package is shielded to permit human access to emplacement drifts and includes an integral filler inside the package to reduce the amount of water that can contact the waste form. Closure of the repository is desired 50 years after first waste is emplaced. Both backfill and drip shields will be emplaced at closure to improve post-closure performance. The EDA IV concept includes more defense-in-depth layers than the VA reference design because of its backfill, drip shield, waste package shielding, and integral filler features. These features contribute to the low dose-rate to the public achieved during the first 10,000 years of repository life as shown in Figure 3. Investigation of the EDA IV concept has led to the following general conclusions: (1) The total life cycle cost for EDA IV is about $21.7 billion which equates to a $11.3 billion net present value (both figures rounded up). (2) The incidence of design basis events for EDA IV is similar to the VA reference design. (3) The emplacement of the waste packages in drifts will be similar to the VA reference design. However, heavier equipment may be required because the shielded waste package will be heavier. (4) The heavier

  6. Review on Korea Participation of Generation IV International Forum (GIF)

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Jewhan; Jeong, Ji-Young; Hahn, Dohee [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2015-05-15

    Generation IV International Forum (GIF) originates from US proposal of an initiative in 2000. The vision was to leapfrog LWR technology and collaborate with international partners to share R and D on advanced nuclear systems. Nine countries and EU joined the initiative and Gen IV concept was defined via technology goals and legal framework. Two years study with more than 100 experts worldwide has evaluated nearly 100 reactor designs and down selected six most promising concepts. In 2005, the first signatures on Framework Agreement were collected and the first research projects were defined in 2006. Korea is one of the founding members of GIF and actively participating in various areas. In 2013, TD was assigned to Korean expert and Korea is endeavoring to enhance the benefit of participation since this turning point. In this paper, pros and cons of engaging with GIF were briefly introduced and items to maximize the benefit were suggested.

  7. Review on Korea Participation of Generation IV International Forum (GIF)

    International Nuclear Information System (INIS)

    Lee, Jewhan; Jeong, Ji-Young; Hahn, Dohee

    2015-01-01

    Generation IV International Forum (GIF) originates from US proposal of an initiative in 2000. The vision was to leapfrog LWR technology and collaborate with international partners to share R and D on advanced nuclear systems. Nine countries and EU joined the initiative and Gen IV concept was defined via technology goals and legal framework. Two years study with more than 100 experts worldwide has evaluated nearly 100 reactor designs and down selected six most promising concepts. In 2005, the first signatures on Framework Agreement were collected and the first research projects were defined in 2006. Korea is one of the founding members of GIF and actively participating in various areas. In 2013, TD was assigned to Korean expert and Korea is endeavoring to enhance the benefit of participation since this turning point. In this paper, pros and cons of engaging with GIF were briefly introduced and items to maximize the benefit were suggested

  8. Targeted NextGen Capabilities for 2025

    Science.gov (United States)

    2011-11-01

    increased arrival capacity to single runways by reducing longitudinal wake separation standards for Instrument Flight Rules ( IFR ) operations under certain...b. ABSTRACT unclassified c. THIS PAGE unclassified Standard Form 298 (Rev. 8-98) Prescribed by ANSI Std Z39-18 Targeted NextGen Capabilities...The examples cited are not intended to cover every aircraft and every flight. In some instances, the available capabilities for 2025 will not be

  9. A sputnik IV saga

    Science.gov (United States)

    Lundquist, Charles A.

    2009-12-01

    The Sputnik IV launch occurred on May 15, 1960. On May 19, an attempt to deorbit a 'space cabin' failed and the cabin went into a higher orbit. The orbit of the cabin was monitored and Moonwatch volunteer satellite tracking teams were alerted to watch for the vehicle demise. On September 5, 1962, several team members from Milwaukee, Wisconsin made observations starting at 4:49 a.m. of a fireball following the predicted orbit of Sputnik IV. Requests went out to report any objects found under the fireball path. An early morning police patrol in Manitowoc had noticed a metal object on a street and had moved it to the curb. Later the officers recovered the object and had it dropped off at the Milwaukee Journal. The Moonwarch team got the object and reported the situation to Moonwatch Headquarters at the Smithsonian Astrophysical Observatory. A team member flew to Cambridge with the object. It was a solid, 9.49 kg piece of steel with a slag-like layer attached to it. Subsequent analyses showed that it contained radioactive nuclei produced by cosmic ray exposure in space. The scientists at the Observatory quickly recognized that measurements of its induced radioactivity could serve as a calibration for similar measurements of recently fallen nickel-iron meteorites. Concurrently, the Observatory directorate informed government agencies that a fragment from Sputnik IV had been recovered. Coincidently, a debate in the UN Committee on Peaceful Uses of Outer Space involved the issue of liability for damage caused by falling satellite fragments. On September 12, the Observatory delivered the bulk of the fragment to the US Delegation to the UN. Two days later, the fragment was used by US Ambassador Francis Plimpton as an exhibit that the time had come to agree on liability for damage from satellite debris. He offered the Sputnik IV fragment to USSR Ambassador P.D. Morozov, who refused the offer. On October 23, Drs. Alla Massevitch and E.K. Federov of the USSR visited the

  10. The Contribution of IVS to IGGOS

    Science.gov (United States)

    Nothnagel, A.

    2002-05-01

    Since its inauguration in 1999, the International VLBI Service for Geodesy and Astrometry has made significant progress in the coordination and utilisation of worldwide VLBI resources. Improving the visibility of the IVS components to a wider public in turn led to a higher motivation of the individuals to contribute to the global effort. Not only the number of IVS components but also their investments in terms of funds and manpower demonstrate the increased awareness of the importance of this joint international endeavour. The different demands of the users but also of the contributors often require the definition of priorities which are only being acceptable due to the existence of a strong umbrella organisation like the IVS. Significant progress has also been made in the area of routine data analysis and combination of results. By now, six IVS Analysis Centers provide the redundancy necessary for a robust combination of the results. The use of ITRF2000 station coordinates as the basis for the IVS combined EOP series is the most recent step towards the generation of a consistent chain from the quasi-inertial frame of radio sources to system Earth.

  11. IVS: Current Status and Future Plans

    Science.gov (United States)

    Behrend, D.; Nothnagel, A.; Petrachenko, W. T.; Tuccari, G.

    2016-12-01

    The International VLBI Service for Geodesy and Astrometry (IVS) is a globally operating service that coordinates and performs Very Long Baseline Interferometry (VLBI) activities through its constituent components. The VLBI activities are associated with the creation, provision, dissemination, and archiving of relevant VLBI data and products. The products mostly pertain to the determination of the celestial and terrestrial reference frames, the Earth orientation parameters (EOP), atmospheric parameters as well as other ancillary parameters. The IVS observational network currently consists of about 40 radio telescopes worldwide. Subsets of these telescopes (8-12 stations) participate in 24-hour observing sessions that are run several times per week and in 1-hour intensive sessions for UT1 determination every day. The current VLBI network was developed mainly in the 1970s and 1980s. A number of factors, including aging infrastructure and demanding new scientific requirements, started to challenge its future sustainability and relevance. In response, the IVS and other groups developed and started implementing the next generation VLBI system, called VGOS (VLBI Global Observing System), at existing and new sites. The VGOS network is expected to reach maturity in the early 2020s. We describe the current status, progress, and anticipated prospects of geodetic/astrometric VLBI and the IVS.

  12. Recommendations and Requirements for GenCade Simluations

    Science.gov (United States)

    2014-08-01

    will report whether or not GenCade is enabled. If GenCade is disabled , the user will need a new license that includes GenCade...any depth but usually are not deeper than the seaward edge of the surf - zone. In the same way that some shorelines are less desirable for use in...Conference, 1919–1937. ASCE. Wang, P., N. C. Kraus, and R. A. Davis. 1998. Total rate of longshore sediment transport in the surf zone: Field

  13. O impacto da genética na asma infantil

    OpenAIRE

    Pinto,Leonardo A.; Stein,Renato T.; Kabesch,Michael

    2008-01-01

    OBJETIVO: Apresentar os resultados dos estudos mais importantes e recentes sobre a genética da asma. Estes dados devem auxiliar os clínicos gerais a compreender o impacto da genética sobre este distúrbio complexo e como os genes e polimorfismos influenciam a asma e a atopia. FONTES DOS DADOS: Os dados foram coletados do banco de dados MEDLINE. Os estudos de associação genética foram selecionados do Genetic Association Database, um repositório de estudos de associação genética de doenças e dis...

  14. Aconselhamento genético Genetic counseling

    Directory of Open Access Journals (Sweden)

    João Monteiro de Pina-Neto

    2008-08-01

    Full Text Available OBJETIVO: Esta revisão sobre aconselhamento genético (AG teve o objetivo de mostrar os conceitos atuais e os princípios filosóficos e éticos aceitos na grande maioria dos países e recomendados pela Organização Mundial da Saúde, as fases do processo, seus resultados e o impacto psicológico de uma doença genética em uma família. FONTES DOS DADOS: Os conceitos apresentados são baseados em uma síntese histórica da literatura sobre AG desde a década de 1930 até o momento atual, sendo que os artigos citados representam os principais trabalhos publicados e que hoje fundamentam a teoria e a prática do AG. SÍNTESE DOS DADOS: O AG modernamente é definido como um processo de comunicação que trata dos problemas humanos relacionados à ocorrência de uma doença genética em uma família. É fundamental que os profissionais da saúde conheçam os aspectos psicológicos desencadeados pela doença genética e como estes aspectos podem ser manejados. Vivemos ainda na genética humana e médica uma fase de predomínio dos aspectos técnicos e científicos e de pouca ênfase no estudo das reações emocionais e dos processos de adaptação das pessoas a estas doenças, o que leva ao baixo entendimento dos clientes sobre os fatos ocorridos, com conseqüências negativas sobre a vida familiar e para a sociedade. CONCLUSÕES: Conclui-se pela necessidade de que as famílias com doenças genéticas sejam encaminhadas para AG e que os profissionais desta área invistam mais na humanização do atendimento, desenvolvendo mais as técnicas do AG psicológico não-diretivo.OBJECTIVE: The objective of this review of genetic counseling (GC is to describe the current concepts and philosophical and ethical principles accepted by the great majority of countries and recommended by the World Health Organization, the stages of the process, its results and the psychological impact that a genetic disease has on a family. SOURCES: The concepts presented are

  15. TidGen Power System Commercialization Project

    Energy Technology Data Exchange (ETDEWEB)

    Sauer, Christopher R. [President & CEO; McEntee, Jarlath [VP Engineering & CTO

    2013-12-30

    ORPC Maine, LLC, a wholly-owned subsidiary of Ocean Renewable Power Company, LLC (collectively ORPC), submits this Final Technical Report for the TidGen® Power System Commercialization Project (Project), partially funded by the U.S. Department of Energy (DE-EE0003647). The Project was built and operated in compliance with the Federal Energy Regulatory Commission (FERC) pilot project license (P-12711) and other permits and approvals needed for the Project. This report documents the methodologies, activities and results of the various phases of the Project, including design, engineering, procurement, assembly, installation, operation, licensing, environmental monitoring, retrieval, maintenance and repair. The Project represents a significant achievement for the renewable energy portfolio of the U.S. in general, and for the U.S. marine hydrokinetic (MHK) industry in particular. The stated Project goal was to advance, demonstrate and accelerate deployment and commercialization of ORPC’s tidal-current based hydrokinetic power generation system, including the energy extraction and conversion technology, associated power electronics, and interconnection equipment capable of reliably delivering electricity to the domestic power grid. ORPC achieved this goal by designing, building and operating the TidGen® Power System in 2012 and becoming the first federally licensed hydrokinetic tidal energy project to deliver electricity to a power grid under a power purchase agreement in North America. Located in Cobscook Bay between Eastport and Lubec, Maine, the TidGen® Power System was connected to the Bangor Hydro Electric utility grid at an on-shore station in North Lubec on September 13, 2012. ORPC obtained a FERC pilot project license for the Project on February 12, 2012 and the first Maine Department of Environmental Protection General Permit issued for a tidal energy project on January 31, 2012. In addition, ORPC entered into a 20-year agreement with Bangor Hydro Electric

  16. A Study on planning of promotion for international collaborative development of Generation IV Nuclear Energy Systems

    International Nuclear Information System (INIS)

    Hee, Chang Moon; Yang, M. S.; Ha, J. J.

    2006-06-01

    Korea has participated in the international collaboration programs for the development of future nuclear energy systems driven by the countries holding advanced nuclear technology and Korea and U. S. have cooperated in the INERI. This study is mainly at developing the plan for participation in the collaborative development of the Gen IV, searching the participation strategy for INERI and the INPRO, and the international cooperation in these programs. Contents and scope of the study for successful achievement are as follows; - Investigation and analysis of international and domestic trends related to advanced nuclear technologies - Development of the plan for collaborative development of the Gen IV and conducting the international cooperation activities - Support for the activities related to I-NERI between Korea and U. S. and conducting the international cooperation - International cooperation activities for the INPRO This study can be useful for planning the research plan and setting up of the strategy of integrating the results of the international collaboration and the domestic R and D results by combining the Gen IV and the domestic R and D in the field of future nuclear technology. Furthermore, this study can contribute to establishing the effective foundation and broadening the cooperation activities not only with the advanced countries for acquisition of the advanced technologies but also with the developing countries for the export of the domestic nuclear energy systems

  17. Analysis of a Spanish energy scenario with Generation IV nuclear reactors

    International Nuclear Information System (INIS)

    Ochoa, Raquel; Jimenez, Gonzalo; Perez-Martin, Sara

    2013-01-01

    Highlights: • Spanish energy scenario for the hypothetical deployment of Gen-IV SFR reactors. • Availability of national resources is assessed, considering SFR’s breeding. • An assessment of the impact of transmuting MA on the final repository. • SERPENT code with own pre- and post-processing tools were employed. • The employed SFR core design is based on the specifications of the CP-ESFR. - Abstract: The advantages of fast-spectrum reactors consist not only of an efficient use of fuel through the breeding of fissile material and the use of natural or depleted uranium, but also of the potential reduction of the amount of actinides such as americium and neptunium contained in the irradiated fuel. The first aspect means a guaranteed future nuclear fuel supply. The second fact is key for high-level radioactive waste management, because these elements are the main responsible for the radioactivity of the irradiated fuel in the long term. The present study aims to analyze the hypothetical deployment of a Gen-IV Sodium Fast Reactor (SFR) fleet in Spain. A nuclear fleet of fast reactors would enable a fuel cycle strategy different than the open cycle, currently adopted by most of the countries with nuclear power. A transition from the current Gen-II to Gen-IV fleet is envisaged through an intermediate deployment of Gen-III reactors. Fuel reprocessing from the Gen-II and Gen-III Light Water Reactors (LWR) has been considered. In the so-called advanced fuel cycle, the reprocessed fuel used to produce energy will breed new fissile fuel and transmute minor actinides at the same time. A reference case scenario has been postulated and further sensitivity studies have been performed to analyze the impact of the different parameters on the required reactor fleet. The potential capability of Spain to supply the required fleet for the reference scenario using national resources has been verified. Finally, some consequences on irradiated final fuel inventory are assessed

  18. Data-Link and Surface Map Traffic Intent Displays for NextGen 4DT and Equivalent Visual Surface Operations

    Science.gov (United States)

    Shelton, Kevin J.; Prinzel, Lawrence J., III; Arthur, Jarvis J., III; Jones, Deise R.; Allamandola, Angela S.; Bailey, Randall E.

    2009-01-01

    By 2025, U.S. air traffic is predicted to increase 3-fold and may strain the current air traffic management system, which may not be able to accommodate this growth. In response to this challenge, a consortium of industry, academia and government agencies have proposed a revolutionary new concept for U.S. aviation operations, termed the Next Generation Air Transportation System or "NextGen". Many key capabilities are being identified to enable NextGen, including the concept of "net-centric" operations whereby each aircraft and air services provider shares information to allow real-time adaptability to ever-changing factors such as weather, traffic, flight trajectories, and security. Data-link is likely to be the primary source of communication in NextGen. Because NextGen represents a radically different approach to air traffic management and requires a dramatic shift in the tasks, roles, and responsibilities for the flight deck, there are numerous research issues and challenges that must be overcome to ensure a safe, sustainable air transportation system. Flight deck display and crew-vehicle interaction concepts are being developed that proactively investigate and overcome potential technology and safety barriers that might otherwise constrain the full realization of NextGen.

  19. Hepatic imaging in stage IV-S neuroblastoma

    International Nuclear Information System (INIS)

    Franken, E.A. Jr.; Smith, W.L.; Iowa Univ., Iowa City; Cohen, M.D.; Kisker, C.T.; Platz, C.E.

    1986-01-01

    Stage IV-S neuroblastoma describes a group of infants with tumor spread limited to liver, skin, or bone marrow. Such patients, who constitute about 25% of affected infants with neuroblastoma, may expect spontaneous tumor remission. We report 18 infants with Stage IV-S neuroblastoma, 83% of whom had liver involvement. Imaging investigations included Technetium 99m sulfur colloid scan, ultrasound, and CT. Two patterns of liver metastasis were noted: ill-defined nodules or diffuse tumor throughout the liver. Distinction of normal and abnormal liver with diffuse type metastasis could be quite difficult, particularly with liver scans. We conclude that patients with Stage IV-S neuroblastoma have ultrasound or CT examination as an initial workup, with nuclear medicine scans reserved for followup studies. (orig.)

  20. Diaquatetrabromidotin(IV trihydrate

    Directory of Open Access Journals (Sweden)

    Fei Ye

    2012-09-01

    Full Text Available The title compound, [SnBr4(H2O2]·3H2O, forms large colourless crystals in originally sealed samples of tin tetrabromide. It constitutes the first structurally characterized hydrate of SnBr4 and is isostructural with the corresponding hydrate of SnCl4. It is composed of SnIV atoms octahedrally coordinated by four Br atoms and two cis-related water molecules. The octahedra exhibit site symmetry 2. They are arranged into columns along [001] via medium–strong O—H...O hydrogen bonds involving the two lattice water molecules (one situated on a twofold rotation axis while the chains are interconnected via longer O—H...Br hydrogen bonds, forming a three-dimensional network.

  1. Cyclopentadienyluranium(IV) acetylacetonates

    International Nuclear Information System (INIS)

    Bagnall, K.W.; Edwards, J.; Rickard, C.E.F.; Tempest, A.C.

    1979-01-01

    Cyclopentadienyluranium(IV) acetylacetonate complexes, (eta 5 C 5 H 5 )UClsub(3-x)(acac)sub(x), where x = 1 or 2, and the corresponding bis triphenylphosphine oxide (tppo) complexes have been prepared. The bis cyclopentadienyl complexes, (eta 5 C 5 H 5 ) 2 U(acac) 2 and (eta 5 C 5 H 5 ) 2 UCl(acac)(tppo) 2 have also been prepared and are stable with respect to disproportionation, whereas (eta 5 C 5 H 5 ) 2 UCl(acac) is not. The IR and UV/visible spectra of the complexes are reported, together with some additional information on the UCl 2 (acac) 2 thf and -tppo systems. (author)

  2. Towards an International Culture: Gen Y Students and SNS?

    Science.gov (United States)

    Lichy, Jessica

    2012-01-01

    This article reports the findings of a small-scale investigation into the Internet user behaviour of generation Y (Gen Y) students, with particular reference to social networking sites. The study adds to the literature on cross-cultural Internet user behaviour with specific reference to Gen Y and social networking. It compares how a cohort of…

  3. Complexity analysis of the Next Gen Air Traffic Management System: trajectory based operations.

    Science.gov (United States)

    Lyons, Rhonda

    2012-01-01

    According to Federal Aviation Administration traffic predictions currently our Air Traffic Management (ATM) system is operating at 150 percent capacity; forecasting that within the next two decades, the traffic with increase to a staggering 250 percent [17]. This will require a major redesign of our system. Today's ATM system is complex. It is designed to safely, economically, and efficiently provide air traffic services through the cost-effective provision of facilities and seamless services in collaboration with multiple agents however, contrary the vision, the system is loosely integrated and is suffering tremendously from antiquated equipment and saturated airways. The new Next Generation (Next Gen) ATM system is designed to transform the current system into an agile, robust and responsive set of operations that are designed to safely manage the growing needs of the projected increasingly complex, diverse set of air transportation system users and massive projected worldwide traffic rates. This new revolutionary technology-centric system is dynamically complex and is much more sophisticated than it's soon to be predecessor. ATM system failures could yield large scale catastrophic consequences as it is a safety critical system. This work will attempt to describe complexity and the complex nature of the NextGen ATM system and Trajectory Based Operational. Complex human factors interactions within Next Gen will be analyzed using a proposed dual experimental approach designed to identify hazards, gaps and elicit emergent hazards that would not be visible if conducted in isolation. Suggestions will be made along with a proposal for future human factors research in the TBO safety critical Next Gen environment.

  4. Caracterização genético-clínica de pacientes com fenilcetonúria no Estado de Alagoas = Genetic and clinical characterization of patients with phenylketonuria in Alagoas state, Brazil

    Directory of Open Access Journals (Sweden)

    Santos, Emerson Santana

    2012-01-01

    Conclusões: O genótipo V388M/IVS10nt11G>A foi o mais prevalente. Trinta por cento dos pacientes foram sintomáticos, provavelmente pela natureza das mutações, não adesão ao tratamento, tratamento inadequado e/ou diagnóstico tardio

  5. Variabilidad genética de Plasmodium falciparum en pacientes con malaria grave y malaria no complicada en Iquitos - Perú

    Directory of Open Access Journals (Sweden)

    Gisely Hijar G

    2002-07-01

    Full Text Available Objetivo: Determinar la diversidad genética del gen que codifica la proteína rica en glutamato (GLURP de Plasmodium falciparum en pacientes con malaria complicada y no complicada circulante en un área del departamento de Loreto, distrito de Maynas. Materiales y métodos: La diversidad genética fue analizada usando reacción en cadena de la polimerasa (PCR en 30 muestras sanguíneas de pacientes con malaria no complicada (MNC y 46 con malaria grave complicada (MGC. Resultados: Ocho genotipos fueron detectados en pacientes con MNC (Genotipo I,II,III, IV,V, VI,VII y VIII y cuatro genotipos en los pacientes con MGC (Genotipo V,VI,VII,VIII. Asimismo, en 50% de las muestras con MNC fueron detectadas infecciones múltiples, a diferencia de las muestras de MGC en donde no se detectó infecciones múltiples. Conclusión: Existe una diversidad genética en esta región del gen GLURP de P. falciparum, para esa época (marzo 1998 - abril 1999 y esa área del país. En tal sentido, nuestros resultados podrían servir de base para llevar a cabo estudios epidemiológicos posteriores, ya que permitiría conocer la distribución de las cepas circulantes en nuestro país.

  6. Factors Influencing Retention of Gen Y and Non-Gen Y Teachers Working at International Schools in Asia

    Science.gov (United States)

    Fong, Hoi Wah Benny

    2018-01-01

    Quantitative studies on international-school teacher retention are few, especially studies that differentiate between Gen Y and non-Gen Y teachers. This article reports on the findings of a study that examined the relationship of job satisfaction factors to the likelihood of contract renewal by international-school teachers. Results from the study…

  7. Heat and power from MicroGen

    Energy Technology Data Exchange (ETDEWEB)

    Anon.

    1999-10-01

    This paper reports on the design of a domestic gas-fired cogeneration system developed to replace the central heating boiler. Technical details of the MicroGen demonstration unit are given, and the use of a Linear Free Piston Stirling Engine as the prime mover, and the results of modelling studies of energy demand indicating cost savings compared to conventional boilers are discussed. The enhancement of the benefits of micro-cogeneration through use of thermal and power storage and energy demand management, and the impact of micro-cogeneration on energy use in the home are considered. The UK and European Commission's targets for increased cogeneration capacity are noted.

  8. NextGen Future Safety Assessment Game

    Science.gov (United States)

    Ancel, Ersin; Gheorghe, Adrian; Jones, Sharon Monica

    2011-01-01

    The successful implementation of the next generation infrastructure systems requires solid understanding of their technical, social, political and economic aspects along with their interactions. The lack of historical data that relate to the long-term planning of complex systems introduces unique challenges for decision makers and involved stakeholders which in turn result in unsustainable systems. Also, the need to understand the infrastructure at the societal level and capture the interaction between multiple stakeholders becomes important. This paper proposes a methodology in order to develop a holistic approach aiming to provide an alternative subject-matter expert (SME) elicitation and data collection method for future sociotechnical systems. The methodology is adapted to Next Generation Air Transportation System (NextGen) decision making environment in order to demonstrate the benefits of this holistic approach.

  9. Congenital bilateral neuroblastoma (stage IV-S): case report

    International Nuclear Information System (INIS)

    Lee, Jeong Hee; Lee, Hee Jung; Woo, Seong Ku; Lee, Sang Rak; Kim, Heung Sik

    2002-01-01

    Congenital neonatal neuroblastoma is not uncommon but bilateral adrenal neuroblastoma is rare, accounting for about ten percent of neuroblastomas in children. We report the US the MR findings of a stage IV-S congenital bilateral neuroblastoma occurring in a one-day-old neonate

  10. The GenDev Curriculum Development Workshop.

    Science.gov (United States)

    D'cunha, J

    1997-01-01

    This article describes the second Curriculum Development Workshop held in May 1997 at the Asian Institute of Technology (AIT) in Bangkok, Thailand. The workshop aimed to review critically and restructure the Gender and Development Studies (GenDev) curriculum and to assess AIT's role in training gender experts for the region. Participants included 22 people from 16 countries in Asia, Europe, and the US who were teaching graduate students about gender issues and who were activists with nongovernmental organizations working on gender issues. It was determined that the following were required courses: Culture, Knowledge and Gender Relations; Gender, Technology, and Development; Principles of Gender Research and Methodology in Science and Technology; and Gender Analysis and Field Methods. Other suggested core courses included: Gender and Natural Resource Management; Enterprise Management, Technology, and Gender; Gender and Agrarian Reform; Urbanization: A Gender Perspective; Gender-Responsive Development Planning; and Gender and Economic Change: Past and Present Concerns. Participants distinguished between GenDev courses offered to anyone attending AIT and training courses designed to produce gender experts in the region. The aim of training courses for AIT graduate students was to sensitize potential managers, technologists, and others on gender issues and to create awareness of the importance of including gender perspectives within decision-making, policy formation, and implementation. Training courses to produce gender experts should be directed to those with a prior background in gender studies and include gender analysis in field methods. Participants agreed that there should be an independent and autonomous field of gender and development studies. Participants made six recommendations for such a field of study.

  11. Policy-induced market introduction of Generation IV reactor systems

    International Nuclear Information System (INIS)

    Heek, Aliki Irina van; Roelofs, Ferry

    2011-01-01

    Almost 10 years ago the U.S. Department of Energy (DOE) started the Generation IV Initiative (GenIV) with 9 other national governments with a positive ground attitude towards nuclear energy. Some of these Generation IV systems, like the fast reactors, are nearing the demonstration stage. The question on how their market introduction will be implemented becomes increasingly urgent. One main topic for future reactor technologies is the treatment of radioactive waste products. Technological solutions to this issue are being developed. One possible process is the transformation of long-living radioactive nuclides into short living ones; a process known as transmutation, which can be done in a nuclear reactor only. Various Generation IV reactor concepts are suitable for this process, and of these systems most experience has been gained with the sodium-cooled fast reactor (SFR). However, both these first generation SFR plants and their Generation IV successors are designed as electricity generating plants, and therefore supposed to be commercially viable in the electricity markets. Various studies indicate that the generation costs of a combined LWR-(S)FR nuclear generating park (LWR: light water reactor) will be higher than that of an LWR-only park. To investigate the effects of the deployment of the different reactors and fuel cycles on the waste produced, resources used and costs incurred as a function of time, a dynamic fuel cycle assessment is performed. This study will focus on the waste impact of the introduction of a fraction of fast reactors in the European nuclear reactor park with a cost increase as described in the previous paragraph. The nuclear fuel cycle scenario code DANESS is used for this, as well as the nuclear park model of the EU-27 used for the previous study. (orig.)

  12. Metode Transfer Asam Nukleat sebagai Dasar Terapi Gen

    Directory of Open Access Journals (Sweden)

    Novi Silvia Hardiany

    2017-01-01

    Full Text Available Kemajuan ilmu biologi molekuler memberikan manfaat dalam bidang kedokteran untuk mengembangkanterapi gen. Tujuan terapi gen adalah untuk memperbaiki kerusakan gen atau mengganti gen yang rusakdengan gen yang normal. Pemindahan gen dilakukan dengan teknik transfeksi. Transfeksi merupakanproses pemindahan asam nukleat baik menggunakan vektor virus (transduksi atau menggunakan metodenonviral yaitu zat kimia, lipid dan metode fisik. Vektor virus yang digunakan pada transduksi adalahretrovirus, adenovirus, adeno-associated virus (AAV dan herpes simplex virus (HSV. Keberhasilantransfeksi ditentukan oleh berbagai faktor yang dapat dapat dinilai dengan menggunakan reporter sepertigreen fluorescence protein (GFP. Kata Kunci: terapi gen, transfeksi non viral, transduksi, vektor virus   Methods of Nucleic Acid Transfer as Basic Gene Therapy Abstract The advancement of molecular biology provides benefit in the field of medicine to develop genetherapy. The aim of gene therapy is to repair the genetic damage or to replace damaged gene with thenormal gene. Delivery of gene is carried out by transfection technique, a technique to transfer nucleic acidinto eukaryote cells either using viral vectors (known as transduction, and also using non viral methodsuch as chemical substance, lipid and physical method. Some of the viral vectors used in the transductionare retrovirus, adenovirus, Adeno-associated virus (AAV and Herpes Simplex Virus (HSV. The success oftransfection is determined by various factors which can be assessed using several reporters such as GreenFluorescence Protein (GFP. Key words: gene therapy, non viral transfection, transduction, viral vector. Normal 0 false false false IN X-NONE X-NONE

  13. Glycogen Storage Disease Type IV

    DEFF Research Database (Denmark)

    Bendroth-Asmussen, Lisa; Aksglaede, Lise; Gernow, Anne B

    2016-01-01

    molecular genetic analyses confirmed glycogen storage disease Type IV with the finding of compound heterozygosity for 2 mutations (c.691+2T>C and c.1570C>T, p.R524X) in the GBE1 gene. We conclude that glycogen storage disease Type IV can cause early miscarriage and that diagnosis can initially be made...

  14. Modelo poblacional con algoritmos genéticos

    OpenAIRE

    Veliz Quintero, Eduardo; Rodriguez Ojeda, Luis

    2009-01-01

    Para el desarrollo de este trabajo, “MODELO POBLACIONAL CON ALGORITMOS GENÉTICOS”, he investigado la rama de la inteligencia artificial, como son los algoritmos genéticos. Primero presento en forma general los aspectos que envuelven los algoritmos genéticos, parto de la necesidad de optimizar, así como su historia y posibles aplicaciones y luego he cubierto detalladamente todo lo que pude investigar sobre la teoría de los algoritmos genéticos, sus fundamentos matemáticos, tipos de algoritmos ...

  15. Sobre el significado del descubrimiento del gen FOXP2

    OpenAIRE

    Longa Martínez, Víctor Manuel

    2006-01-01

    El reciente descubrimiento del gen FOXP2 ha ofrecido la primera evidencia clara de la base genética del lenguaje, mostrando una correlación inequívoca desde la perspectiva genética entre una versión mutada de F0XP2 y los trastornos lingüísticos de diferente tipo sufridos por una familia inglesa, conocida como KE. El objetivo central del presente trabajo es discutir diferentes aspectos relacionados con tal descubrimiento; especialmente, la discusión del significado de FOXP2 con ...

  16. About the structure and stability of complex carbonates of thorium (IV), cerium (IV), zirconium (IV), hafnium (IV)

    International Nuclear Information System (INIS)

    Dervin, Jacqueline

    1972-01-01

    This research thesis addressed the study of complex carbonates of cations of metals belonging to the IV A column, i.e. thorium (IV), zirconium (IV), hafnium (IV), and also cerium (IV) and uranium (VI), and more particularly focused on ionic compounds formed in solution, and also on the influence of concentration and nature of cations on stability and nature of the formed solid. The author first presents methods used in this study, discusses their precision and scope of validity. She reports the study of the formation of different complex ions which have been highlighted in solution, and the determination of their formation constants. She reports the preparation and study of the stability domain of solid complexes. The next part reports the use of thermogravimetric analysis, IR spectrometry, and crystallography for the structural study of these compounds

  17. TrayGen: Arranging objects for exhibition and packaging

    KAUST Repository

    Yang, Yongliang; Huang, Qixing

    2013-01-01

    We present a framework, called TrayGen, to generate tray designs for the exhibition and packaging of a collection of objects. Based on principles from shape perception and visual merchandising, we abstract a number of design guidelines on how

  18. EPCGen2 Pseudorandom Number Generators: Analysis of J3Gen

    Directory of Open Access Journals (Sweden)

    Alberto Peinado

    2014-04-01

    Full Text Available This paper analyzes the cryptographic security of J3Gen, a promising pseudo random number generator for low-cost passive Radio Frequency Identification (RFID tags. Although J3Gen has been shown to fulfill the randomness criteria set by the EPCglobal Gen2 standard and is intended for security applications, we describe here two cryptanalytic attacks that question its security claims: (i a probabilistic attack based on solving linear equation systems; and (ii a deterministic attack based on the decimation of the output sequence. Numerical results, supported by simulations, show that for the specific recommended values of the configurable parameters, a low number of intercepted output bits are enough to break J3Gen. We then make some recommendations that address these issues.

  19. Introducing AstroGen: The Astronomy Genealogy Project

    OpenAIRE

    Tenn, Joseph S.

    2016-01-01

    The Astronomy Genealogy Project ("AstroGen"), a project of the Historical Astronomy Division of the American Astronomical Society (AAS), will soon appear on the AAS website. Ultimately, it will list the world's astronomers with their highest degrees, theses for those who wrote them, academic advisors (supervisors), universities, and links to the astronomers or their obituaries, their theses when on-line, and more. At present the AstroGen team is working on those who earned doctorates with ast...

  20. Parapedobacter koreensis gen. nov., sp. nov.

    Science.gov (United States)

    Kim, Myung Kyum; Na, Ju-Ryun; Cho, Dong Ha; Soung, Nak-Kyun; Yang, Deok-Chun

    2007-06-01

    Strain Jip14(T), a Gram-negative, non-spore-forming, rod-shaped, non-motile bacterium, was isolated from dried rice straw and characterized in order to determine its taxonomic position. 16S rRNA gene sequence analysis revealed that strain Jip14(T) belongs to the family Sphingobacteriaceae, and the highest degree of sequence similarity was determined to be to Pedobacter saltans DSM 12145(T) (88.5 %), Pedobacter africanus DSM 12126(T) (87.6 %), Pedobacter heparinus DSM 2366(T) (87.1 %) and Pedobacter caeni LMG 22862(T) (86.9 %). Chemotaxonomic data revealed that strain Jip14(T) possesses menaquinone MK-7 and the predominant fatty acids C(15 : 0) iso, C(16 : 0), C(16 : 0) 10-methyl, C(17 : 0) iso 3-OH and summed feature 3 (C(15 : 0) iso 2-OH/C(16 : 1)omega7c). The results of physiological and biochemical tests clearly demonstrated that strain Jip14(T) represents a distinct species. Based on these data, Jip14(T) should be classified within a novel genus and species, for which the name Parapedobacter koreensis gen. nov., sp. nov. is proposed. The type strain of Parapedobacter koreensis is Jip14(T) (=KCTC 12643(T)=LMG 23493(T)).

  1. Banque Cantonale de Genève

    CERN Multimedia

    Banque Cantonale de Genève

    2011-01-01

    7e Salon Immobilier BCGE le samedi 3 septembre 2011, de 8 h 30 à 13 h 00, au Centre de formation de Conches À cette occasion, les meilleurs spécialistes professionnels genevois de l’immobilier seront réunis en un seul et même lieu. Si vous le souhaitez, un conseiller spécialisé dans les financements hypothécaires évaluera vos possibilités d’investissement immobilier adaptées à votre situation personnelle. En parallèle, les plus importantes régies immobilières de Genève seront à votre disposition pour vous présenter leurs offres actuelles, ainsi que les projets immobiliers futurs et discuter avec vous de la meilleure stratégie à adopter pour trouver l’objet de vos rêves. De plus, vous aurez la possibilité...

  2. Direct Bandgap Group IV Materials

    Science.gov (United States)

    2016-01-21

    AFRL-AFOSR-JP-TR-2017-0049 Direct Bandgap group IV Materials Hung Hsiang Cheng NATIONAL TAIWAN UNIVERSITY Final Report 01/21/2016 DISTRIBUTION A...NAME(S) AND ADDRESS(ES) NATIONAL TAIWAN UNIVERSITY 1 ROOSEVELT RD. SEC. 4 TAIPEI CITY, 10617 TW 8. PERFORMING ORGANIZATION REPORT NUMBER 9. SPONSORING...14. ABSTRACT Direct bandgap group IV materials have been long sought for in both academia and industry for the implementation of photonic devices

  3. IVS contribution to the next ITRF

    Science.gov (United States)

    Bachmann, Sabine; Messerschmitt, Linda; Thaller, Daniela

    2015-04-01

    Generating the contribution of the International VLBI Service (IVS) to the next ITRF (ITRF2013 or ITRF2014) was the main task of the IVS Combination Center at the Federal Agency for Cartography and Geodesy (BKG, Germany) in 2014. Starting with the ITRF2005, the IVS contribution to the ITRF is an intra-technique combined solution using multiple individual contributions from different institutions. For the upcoming ITRF ten international institutions submitted data files for a combined solution. The data files contain 24h VLBI sessions from the late 1970s until the end of 2014 in SINEX file format containing datum free normal equations with station coordinates and Earth Orientation Parameters (EOP). All contributions have to meet the IVS standards for ITRF contribution in order to guarantee a consistent combined solution. In the course of the generation of the intra-technique combined solution, station coordinate time series for each station as well as a Terrestrial Reference Frame based on the contributed VLBI data (VTRF) were generated and analyzed. Preliminary results using data until the end of 2013 show a scaling factor of -0.47 ppb resulting from a 7-parameter Helmert transformation of the VTRF w.r.t. ITRF2008, which is comparable to the scaling factor that was determined in the precedent ITRF generation. An internal comparison of the EOPs between the combined solution and the individual contributions as well as external comparisons of the EOP series were carried out in order to assure a consistent quality of the EOPs. The data analyses, the combination procedure and results of the combined solution for station coordinates and EOP will be presented.

  4. Estimación de parámetros genéticos para características productivas y reproductivas en los sistemas doble propósito del trópico bajo colombiano

    Directory of Open Access Journals (Sweden)

    A. P. Galeano

    2010-01-01

    Full Text Available Con el objetivo de estimar los componentes de varianza, las heredabilidades, repetibilidades y correlaciones genéticas y fenotípicas para la producción de leche por lactancia (PL, el peso al destete (PD, el intervalo entre partos (IEP y el Índice de Vaca (IV, de las hembras bovinas manejadas en los sistemas de producción de doble propósito del trópico bajo colombiano, se analizaron los registros productivos y reproductivos de 1.687 vacas registradas en la Asociación Colombiana de Criadores de Ganado en Doble Propósito (Asodoble, durante el periodo comprendido entre 1998 y 2007. Se empleó un modelo animal mixto que incluyó los efectos fijos del grupo contemporáneo (finca-sexo-época-año, la composición racial, y la duración de la lactancia como covariable; así como los efectos genéticos aleatorios del animal, el medio ambiente permanente y el residual. Las heredabilidades estimadas para IEP (0,04 y PD (0,11 fueron bajas, y moderadas para PL (0,35 e IV (0,24, respectivamente. La repetibilidad estimada para IEP fue baja (0,08, y para PL (0,41 e IV (0,31 moderada; en el caso de PD este valor fue igual a la heredabilidad (0,11. Las correlaciones genéticas y fenotípicas obtenidas entre PL y PD con respecto a IEP fueron positivas, y se determinó una asociación genética negativa entre PL y PD. Los resultados demostraron que el IV es un buen indicador, desde el punto de vista genético, de la eficiencia productiva y reproductiva de los animales manejados en estos sistemas productivos.

  5. Generation IV reactors: economics

    International Nuclear Information System (INIS)

    Dupraz, B.; Bertel, E.

    2003-01-01

    The operating nuclear reactors were built over a short period: no more than 10 years and today their average age rounds 18 years. EDF (French electricity company) plans to renew its reactor park over a far longer period : 30 years from 2020 to 2050. According to EDF this objective implies 3 constraints: 1) a service life of 50 to 60 years for a significant part of the present operating reactors, 2) to be ready to built a generation 3+ unit in 2020 which infers the third constraint: 3) to launch the construction of an EPR (European pressurized reactor) prototype as soon as possible in order to have it operating in 2010. In this scheme, generation 4 reactor will benefit the feedback experience of generation 3 and will take over in 2030. Economic analysis is an important tool that has been used by the generation 4 international forum to select the likely future reactor systems. This analysis is based on 4 independent criteria: the basic construction cost, the construction time, the operation and maintenance costs and the fuel cycle cost. This analysis leads to the evaluation of the global cost of electricity generation and of the total investment required for each of the reactor system. The former defines the economic competitiveness in a de-regulated energy market while the latter is linked to the financial risk taken by the investor. It appears, within the limits of the assumptions and models used, that generation 4 reactors will be characterized by a better competitiveness and an equivalent financial risk when compared with the previous generation. (A.C.)

  6. 45 CFR 309.145 - What costs are allowable for Tribal IV-D programs carried out under § 309.65(a) of this part?

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 2 2010-10-01 2010-10-01 false What costs are allowable for Tribal IV-D programs... ENFORCEMENT (IV-D) PROGRAM Tribal IV-D Program Funding § 309.145 What costs are allowable for Tribal IV-D... maintenance of essential Office Automation capability; (4) Establishment of Intergovernmental Service...

  7. Corrosion of structural materials for Generation IV systems

    International Nuclear Information System (INIS)

    Balbaud-Celerier, F.; Cabet, C.; Courouau, J.L.; Martinelli, L.; Arnoux, P.

    2009-01-01

    The Generation IV International Forum aims at developing future generation nuclear energy systems. Six systems have been selected for further consideration: sodium-cooled fast reactor (SFR), gas-cooled fast reactor (GFR), lead-cooled fast reactor (LFR), molten salt reactor (MSR), supercritical water-cooled reactor (SCWR) and very high temperature reactor (VHTR). CEA, in the frame of a national program, of EC projects and of the GIF, contributes to the structural materials developments and research programs. Particularly, corrosion studies are being performed in the complex environments of the GEN IV systems. As a matter of fact, structural materials encounter very severe conditions regarding corrosion concerns: high temperatures and possibly aggressive chemical environments. Therefore, the multiple environments considered require also a large diversity of materials. On the other hand, the similar levels of working temperatures as well as neutron spectrum imply also similar families of materials for the various systems. In this paper, status of the research performed in CEA on the corrosion behavior of the structural material in the different environments is presented. The materials studied are either metallic materials as austenitic (or Y, La, Ce doped) and ferrito-martensitic steels, Ni base alloys, ODS steels, or ceramics and composites. In all the environments studied, the scientific approach is identical, the objective being in all cases the understanding of the corrosion processes to establish recommendations on the chemistry control of the coolant and to predict the long term behavior of the materials by the development of corrosion models. (author)

  8. Communications strategy representatives of the national population and family planning (BKKBN) of West Sumatera Province in promotion planning program Generasi Berencana (GenRe)

    OpenAIRE

    Endri, Engga Probi

    2017-01-01

    Generasi Berencana (GenRe) is a program of the BKKBN in response to all the problems of adolescence so that teens can be protected from the risk of KRR triad. Promotional activities are highly needed in promoting something – service and things. the media is one of the most influential component to the success of such promotional activities. This study aimed to describe the media campaign that used BKKBN representatives of West Sumatera province through a program GenRe (Generation Planning), k...

  9. Seleção preliminar de genótipos de pinheira em Bom Jesus-PI Preliminary selection of sugar apple genotypes in Bom Jesus county, Piauí state, Brazil

    Directory of Open Access Journals (Sweden)

    Ítalo Herbert Lucena Cavalcante

    2011-01-01

    Full Text Available A pinheira (Annona squamosa L. ocorre espontaneamente no Nordeste Brasileiro, onde é explorada de forma extrativista, caracterizando-se pela falta de manejo adequado e material genético selecionado. Nesse sentido, foi realizado um experimento com objetivo de avaliar a produtividade, as características físicas e químicas de frutos de dez genótipos de pinheira no município de Bom Jesus, PI. Adotou-se delineamento inteiramente casualizado, com tratamentos representados por dez genótipos de pinheira e três repetições. Foram avaliadas as seguintes variáveis: vitamina C, acidez titulável, sólidos solúveis, relação SS/AT "ratio", diâmetros longitudinal e transversal, relação DL/DT, número se sementes por fruto, massa dos frutos e produção por planta. Os genótipos apresentam diferenças quanto às características químicas, físicas e produtivas dos frutos. Os genótipos foram agrupados em sete grupos, com destaque para o grupo III (Gen-02 e grupo IV (Gen-05, fato que explicitou as diferenças entre os genótipos de pinheira quanto às características produtivas e químicas e físicas dos frutos. Genótipos Gen-01 e Gen-02 apresentam potencial para instalação em plantios comerciais, pela produtividade, formato do fruto ou por caracterizarem fontes naturais de vitamina C.The sugar apple (Annona squamosa L. is native to tropical America, occurring spontaneously in Northeastern Brazil, where it is exploited mainly as subsistence without adequate management and without genetic material selection. An experiment was developed aiming to evaluate yield, physical and chemical characteristics of the fruits of ten sugar apple genotypes in Bom Jesus, Piauí State, Brazil. A completely randomized design with treatments represented by ten genotypes and three replications was adopted. The following variables were evaluated: vitamin C, titratable acidity, soluble solids, SS/TA ratio, longitudinal diameter and transverse, LD/TD, number of

  10. Description of the IV + V System Software Package.

    Science.gov (United States)

    Microcomputers for Information Management: An International Journal for Library and Information Services, 1984

    1984-01-01

    Describes the IV + V System, a software package designed by the Institut fur Maschinelle Dokumentation for the United Nations General Information Programme and UNISIST to support automation of local information and documentation services. Principle program features and functions outlined include input/output, databank, text image, output, and…

  11. Generation IV Nuclear Energy Systems Construction Cost Reductions through the Use of Virtual Environments - Final Report

    International Nuclear Information System (INIS)

    Timothy Shaw; Anthony Baratta; Vaughn Whisker

    2005-01-01

    Final report of 3 year DOE NERI-sponsored effort evaluating immersive virtual reality (CAVE) technology for design review, construction planning, and maintenance planning and training for next generation nuclear power plants. Program covers development of full-scale virtual mockups generated from 3D CAD data presented in a CAVE visualization facility. Mockups applied to design review of AP600/1000, Construction planning for AP 600, and AP 1000 maintenance evaluation. Proof of concept study also performed for GenIV PBMR models

  12. Generation IV Nuclear Energy Systems Construction Cost Reductions through the Use of Virtual Environments - Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Timothy Shaw; Anthony Baratta; Vaughn Whisker

    2005-02-28

    Final report of 3 year DOE NERI-sponsored effort evaluating immersive virtual reality (CAVE) technology for design review, construction planning, and maintenance planning and training for next generation nuclear power plants. Program covers development of full-scale virtual mockups generated from 3D CAD data presented in a CAVE visualization facility. Mockups applied to design review of AP600/1000, Construction planning for AP 600, and AP 1000 maintenance evaluation. Proof of concept study also performed for GenIV PBMR models.

  13. Mechanisms Governing the Creep Behavior of High Temperature Alloys for Generation IV Nuclear Energy Systems

    International Nuclear Information System (INIS)

    Vasudevan, Vijay; Carroll, Laura; Sham, Sam

    2015-01-01

    This research project, which includes collaborators from INL and ORNL, focuses on the study of alloy 617 and alloy 800H that are candidates for applications as intermediate heat exchangers in GEN IV nuclear reactors, with an emphasis on the effects of grain size, grain boundaries and second phases on the creep properties; the mechanisms of dislocation creep, diffusional creep and cavitation; the onset of tertiary creep; and theoretical modeling for long-term predictions of materials behavior and for high temperature alloy design.

  14. Mechanisms Governing the Creep Behavior of High Temperature Alloys for Generation IV Nuclear Energy Systems

    Energy Technology Data Exchange (ETDEWEB)

    Vasudevan, Vijay [Univ. of Cincinnati, OH (United States); Carroll, Laura [Idaho National Lab. (INL), Idaho Falls, ID (United States); Sham, Sam [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2015-04-06

    This research project, which includes collaborators from INL and ORNL, focuses on the study of alloy 617 and alloy 800H that are candidates for applications as intermediate heat exchangers in GEN IV nuclear reactors, with an emphasis on the effects of grain size, grain boundaries and second phases on the creep properties; the mechanisms of dislocation creep, diffusional creep and cavitation; the onset of tertiary creep; and theoretical modeling for long-term predictions of materials behavior and for high temperature alloy design.

  15. ANALISIS GEN HAEMAGGLUTININ PADA VIRUS CAMPAK LIAR

    Directory of Open Access Journals (Sweden)

    Subangkit Subangkit

    2015-05-01

    Full Text Available AbstrakPenyakit Campak disebabkan oleh virus campak yang termasuk genus Morbilivirus dan Family Paramyxoviridae. Penyakit campak masih menjadi masalah kesehatan karena masih ditemukan Kejadian Luar Biasa (KLB di Indonesia. Salah satu penyebab terjadinya KLB tersebut diduga sebagaiakibat perbedaan antigenesitas antara strain vaksin yang digunakan dengan strain virus campak liar yang beredar di Indonesia. Penelitian ini bertujuan mendapatkan gambaran tentang karakteristik genetik gen Haemagglutinin virus campak liar yang ada di Indonesia. Spesimen yang digunakan sebanyak 27 isolat virus penyebab KLB dari 17 propinsi selama periode tahun 2003-2010. Isolat virus dilakukan pemeriksaan secara RT-PCR dan sekuensing dengan metode Sanger. Hasil sekuensing dianalisis dengan menggunakan perangkat lunak Bioedit 7.0 dan MEGA 4.0. Hasil penelitian didapatkan perbedaan 10 asam amino antara virus campak strain vaksin CAM-70 dan virus campak liar pada posisi D416N; K424T; V451M; N455T; V466I; I473T; F476L; Y481S atau Y481N; H495N; G505D. Kesimpulan penelitian ini adalah terdapat perbedaan karakteristik genetik antara virus campak liar di Indonesia berbeda dengan strain virus vaksin CAM-70.Kata kunci : Campak, Analisis Molekuler, Hemagglutinin, CD46AbstractMeasles is caused by virus belonging to the genus Morbilivirus and Family Paramyxoviridae. Measles is still a public health problem because outbreak of measles still found in Indonesia. Outbreak is suspected as a result of differences in antigenicity between vaccine strains used with wild-type measles virus strains circulating in Indonesia. This study aims to get genetic characteristics of wild-type measles virus haemagglutinin gene in Indonesia. The specimens were used 27 viral isolates from 17 provinces period 2003-2010. Viral isolates examined by RT-PCR and sequencing with Sanger method. Sequencing analysis were conducted using Bioedit 7.0 and MEGA 4.0 software. The results showed 10 amino acid differences

  16. Advanced Computational Materials Science: Application to Fusion and Generation IV Fission Reactors (Workshop Report)

    Energy Technology Data Exchange (ETDEWEB)

    Stoller, RE

    2004-07-15

    The ''Workshop on Advanced Computational Materials Science: Application to Fusion and Generation IV Fission Reactors'' was convened to determine the degree to which an increased effort in modeling and simulation could help bridge the gap between the data that is needed to support the implementation of these advanced nuclear technologies and the data that can be obtained in available experimental facilities. The need to develop materials capable of performing in the severe operating environments expected in fusion and fission (Generation IV) reactors represents a significant challenge in materials science. There is a range of potential Gen-IV fission reactor design concepts and each concept has its own unique demands. Improved economic performance is a major goal of the Gen-IV designs. As a result, most designs call for significantly higher operating temperatures than the current generation of LWRs to obtain higher thermal efficiency. In many cases, the desired operating temperatures rule out the use of the structural alloys employed today. The very high operating temperature (up to 1000 C) associated with the NGNP is a prime example of an attractive new system that will require the development of new structural materials. Fusion power plants represent an even greater challenge to structural materials development and application. The operating temperatures, neutron exposure levels and thermo-mechanical stresses are comparable to or greater than those for proposed Gen-IV fission reactors. In addition, the transmutation products created in the structural materials by the high energy neutrons produced in the DT plasma can profoundly influence the microstructural evolution and mechanical behavior of these materials. Although the workshop addressed issues relevant to both Gen-IV and fusion reactor materials, much of the discussion focused on fusion; the same focus is reflected in this report. Most of the physical models and computational methods

  17. International VLBI Service for Geodesy and Astronomy

    Science.gov (United States)

    Vandenberg, Nancy R. (Editor); Baver, Karen D. (Editor)

    2004-01-01

    This volume of reports is the 2003 Annual Report of the International VLBI Service for Geodesy and Astrometry (IVS). The individual reports were contributed by VLBI groups in the international geodetic and astrometric community who constitute the permanent components of IVS. The IVS 2003 Annual Report documents the work of the IVS components for the calendar year 2003, our fifih year of existence. The reports describe changes, activities, and progress of the IVS. Many thanks to all IVS components who contributed to this Annual Report. The entire contents of this Annual Report also appear on the IVS web site at http://ivscc.gsfc.nasa.gov/publications/ar2OO3

  18. Free-format RPG IV

    CERN Document Server

    Martin, Jim

    2013-01-01

    This how-to guide offers a concise and thorough introduction to the increased productivity, better readability, and easier program maintenance that comes with the free-format style of programming in RPG IV. Although free-format information is available in IBM manuals, it is not separated from everything else, thereby requiring hours of tedious research to track down the information needed. This book provides everything one needs to know to write RPG IV in the free-format style, and author Jim Martin not only teaches rules and syntax but also explains how this new style of coding has the pot

  19. Genética e hanseníase

    Directory of Open Access Journals (Sweden)

    Bernardo Beiguelman

    Full Text Available As diferentes linhas de pesquisa utilizadas para investigar a importância dos fatores hereditários humanos na determinação da resistência/suscetibilidade à infecção pelo Mycobacterium leprae foram discutidas no presente trabalho. Uma síntese dessas abordagens permitiu analisar os resultados das investigações sobre associação da hanseníase com polimorfismos genéticos, distribuição familial da hanseníase, prevalência da hanseníase e distância genética, concordância da hanseníase em gêmeos e estudos genéticos sobre a reação de Mitsuda.

  20. Estudios sobre plantas andinas,- IV

    Directory of Open Access Journals (Sweden)

    Cuatrecasas José

    1943-04-01

    Full Text Available Caracteres genéricos:-Capitulo radiado, con flores dimorfas, las externas apenas más largas que las interiores. Invólucro cónico, de brácteas pluriseriadas pero poco numerosas, flojas, lineal-lanceoladas, agudas, de consistencia herbácea incluso en la fructificación, más largas que el resto del capitulo. Receptáculo alveolado ,con el margen de las fositas ,escamoso-lacerado. Corolas exteriores femeninas, liguladas, con tubo muy corto y casi rectas, ,con 4 líneas longitudinales y 3 dientes gruesos y callosos, en 2-3 filas, con frecuencia provistas de un apéndice lineal en la garganta, rudimento de labio superior.

  1. Craniostenose em gêmeos: estudo genético

    Directory of Open Access Journals (Sweden)

    Walter Carlos Pereira

    1968-09-01

    Full Text Available É relatada a ocorrência de formas clínicas diversas de craniostenose em gêmeos de sexo diferente. A menina apresentava obliteração completa da sutura coronaria e dos dois terços anteriores da sutura sagital; no menino a sutura sagital era a única afetada. O estudo genético mostrou que a craniostenose independe de aberrações cromossômicas, indicando ser transmitida por gens recessivos raros de natureza autossômica.

  2. Introducing AstroGen: the Astronomy Genealogy Project

    Science.gov (United States)

    Tenn, Joseph S.

    2016-12-01

    The Astronomy Genealogy Project (AstroGen), a project of the Historical Astronomy Division of the American Astronomical Society (AAS), will soon appear on the AAS website. Ultimately, it will list the world's astronomers with their highest degrees, theses for those who wrote them, academic advisors (supervisors), universities, and links to the astronomers or their obituaries, their theses when online, and more. At present the AstroGen team is working on those who earned doctorates with astronomy-related theses. We show what can be learned already, with just ten countries essentially completed.

  3. La genética de las poblaciones centroamericanas

    OpenAIRE

    Barrantes, Ramiro

    2005-01-01

    Las poblaciones centroamericanas no han sido objeto de muchos estudios genéticos con la excepción de análisis esporádicos de la variación entre y dentro de los grupos amerindios y de origen africano ubicados en el área. No obstante, en los últimos 15 años se efectuaron investigaciones sistemáticas en este sentido incluyendo poblaciones mestizas, particularmente las de Costa Rica y Panamá. En los amerindios se efectuaron estudios detallados de su estructura genética y las relaciones filogenéti...

  4. Genes and proteins of Escherichia coli (GenProtEc).

    Science.gov (United States)

    Riley, M; Space, D B

    1996-01-01

    GenProtEc is a database of Escherichia coli genes and their gene products, classified by type of function and physiological role and with citations to the literature for each. Also present are data on sequence similarities among E.coli proteins with PAM values, percent identity of amino acids, length of alignment and percent aligned. The database is available as a PKZip file by ftp from mbl.edu/pub/ecoli.exe. The program runs under MS-DOS on IMB-compatible machines. GenProtEc can also be accessed through the World Wide Web at URL http://mbl.edu/html/ecoli.html.

  5. 11. IV avati Draakoni galeriis...

    Index Scriptorium Estoniae

    2005-01-01

    Tanel Saare (sünd. 1979) näitus "Gott und huhn episode IV: seed shower". Eksponeeritakse väljavõtteid aktsioonidest aastatel 2000-2004 Turus, Nürnbergis, Berliinis, Lohusalus ja Soulis. Osa aktsioone toimus koos rühmitusega Non Grata

  6. Estimación de parámetros genéticos para características productivas y reproductivas en los sistemas doble propósito del trópico bajo colombiano

    Directory of Open Access Journals (Sweden)

    A. P. Galeano

    2010-06-01

    Full Text Available Con el objetivo de estimar los componentes de varianza, las heredabilidades, repetibilidadesy correlaciones genéticas y fenotípicas para la producción de leche por lactancia(PL, el peso al destete (PD, el intervalo entre partos (IEP y el Índice de Vaca (IV,de las hembras bovinas manejadas en los sistemas de producción de doble propósitodel trópico bajo colombiano, se analizaron los registros productivos y reproductivosde 1.687 vacas registradas en la Asociación Colombiana de Criadores de Ganado enDoble Propósito (Asodoble, durante el periodo comprendido entre 1998 y 2007. Seempleó un modelo animal mixto que incluyó los efectos fijos del grupo contemporáneo(finca-sexo-época-año, la composición racial, y la duración de la lactancia comocovariable; así como los efectos genéticos aleatorios del animal, el medio ambientepermanente y el residual. Las heredabilidades estimadas para IEP (0,04 y PD (0,11fueron bajas, y moderadas para PL (0,35 e IV (0,24, respectivamente. La repetibilidadestimada para IEP fue baja (0,08, y para PL (0,41 e IV (0,31 moderada; en el casode PD este valor fue igual a la heredabilidad (0,11. Las correlaciones genéticas y fenotípicasobtenidas entre PL y PD con respecto a IEP fueron positivas, y se determinóuna asociación genética negativa entre PL y PD. Los resultados demostraron que el IVes un buen indicador, desde el punto de vista genético, de la eficiencia productiva yreproductiva de los animales manejados en estos sistemas productivos.

  7. Analisis Mutasi Gen Protein X Virus Hbv Pada Penderita Hepatitis B Akut Di Manado

    OpenAIRE

    Fatimawali; Kepel, Billy

    2014-01-01

    Faktor-faktor yang mempengaruhi perkembangan hepatitis B kronis menjadi kanker hati antara lain mutasi pada gen x. Penelitian ini bertujuan untuk mengidentifikasi gen protein x virus HBV dan menganalisis apakah terjadi mutasi gen yang terkait dengan munculnya tumor ganas sirosis hati (HCC). Penelitian ini menggunakan primer untuk proses nested PCR yang telah dirancang sebelumnya. Proses nested PCR terhadap 10 sampel DNA HBV pasien dilakukan untuk mengamplifikasi fragmen DNA gen x dilanjutkan ...

  8. Fast reactor development and worldwide cooperation in Generation-IV International Forum

    International Nuclear Information System (INIS)

    Sagayama, Yutaka

    2013-01-01

    Objectives of Gen-IV systems development: Goals: Four challenging technology goals have been defined to be applied to innovative nuclear reactor concepts in the 21st century: 1) Safety and Reliability (safe and reliable operation, no offsite emergency response); 2) Sustainability (effective fuel utilization, minimization of nuclear waste); 3) Proliferation Resistance & Physical Protection (to assure unattractive and the least desirable route for diversion or theft of weapons-usable materials, and provide increased physical protection against acts of terrorism); 4) Economic Competitiveness (life-cycle cost advantage over other energy resources). Phase: Each Generation-IV reactor system is one of three stages. 1) Viability Phase; 2) Performance Phase; 3) Demonstration Phase. Target: Commercial Deployment is expected around 2030s or beyond

  9. US Nuclear Regulatory Commission region IV

    International Nuclear Information System (INIS)

    Vanderburch, C.

    1996-01-01

    The NRC has established a policy to provide for the timely through and systematic inspection of significant operational events at nuclear power plants. This includes the use of an Augmented Inspection Team to determine the causes, conditions, and circumstances relevant to an event and to communicate its findings and conclusions to NRC management. In accordance with NRC Inspection Manual Chapter 0325. The Region IV Regional Administrator dispatched an Augmented Inspection Team to the Wolf Creek Nuclear Generating Station to review the circumstances surrounding a manual reactor trip on January 30, 1996, with the failure of five control rods to fully insert into the core, a failure of the turbine-driven auxiliary feedwater pump, and the subsequent loss of one train of the essential service water system

  10. Epidemiologia genética: epidemiologia, genética ou nenhuma das anteriores?

    Directory of Open Access Journals (Sweden)

    Aguinaldo Gonçalves

    1990-12-01

    Full Text Available No esforço de contribuir para melhor entendimento da identidade da Epidemiologia Genética, são revistas sua concepção, campo de atuação, métodos e técnicas pertinentes e algumas instâncias de aplicação. Entendendo-a como a área de interesse dos fatores genéticos das doenças e suas interações ambientais, apresenta-se seu campo de atuação como constituído por dois segmentos: um descritivo, que lida com conhecimento da distribuição de tais afecções em famílias e populações, seu impacto a nível do coletivo e sua vigilância epidemiológica, bem como o estudo de seus determinantes; o segundo, caracterizado pela intervenção, refere-se às respectivas medidas preventivas. Em que pese possível limitação pela não-consideração de todas as situações existentes, particular atenção é destinada à revisão de métodos e técnicas que possam ser convergentemente aplicados, a partir de procedimentos genéticos e epidemiológicos. Entre eles, destacam-se como estudos de casos tanto metodologias laboratoriais (como os dermatóglifos quanto quantitativos, como cálculo de herdabilidade e análise multivariada. Alguns objetos de estudo são tomados como instância de aplicação, por contarem com investigações específicas em nosso meio: a hanseníase, o hidrargirismo e a esquizofrenia.In an attempt to contribute to a better undestanding of the identity of Genetic Epidemiology, we review its conception, its field of influence, its appropriate methods and techniques and, at last, some of its applications. Genetic Epidemiology involves the study of genetic factors acting on diseases and on their environmental interactions. These includes two major areas: a descriptive one, related to the distribution of such conditions in families and populations, to the epidemiologic surveillance and to the study of determinants; and another characterized by intervention, which is related to preventive measures. Because of the dificulty in

  11. Revision of Corallinaceae (Corallinales, Rhodophyta): recognizing Dawsoniolithon gen. nov., Parvicellularium gen. nov. and Chamberlainoideae subfam. nov. containing Chamberlainium gen. nov. and Pneophyllum.

    Science.gov (United States)

    Caragnano, Annalisa; Foetisch, Alexandra; Maneveldt, Gavin W; Millet, Laurent; Liu, Li-Chia; Lin, Showe-Mei; Rodondi, Graziella; Payri, Claude E

    2018-03-25

    A multi-gene (SSU, LSU, psbA and COI) molecular phylogeny of the family Corallinaceae (excluding the subfamilies Lithophylloideae and Corallinoideae) showed a paraphyletic grouping of six monophyletic clades. Pneophyllum and Spongites were reassessed and recircumscribed using DNA sequence data integrated with morpho-anatomical comparisons of type material and recently collected specimens. We propose Chamberlainoideae subfam. nov., including the type genus Chamberlainium gen. nov., with C. tumidum comb. nov. as the generitype, and Pneophyllum. Chamberlainium is established to include several taxa previously ascribed to Spongites, the generitype of which currently resides in Neogoniolithoideae. Additionally we propose two new genera, Dawsoniolithon gen. nov. (Metagoniolithoideae), with D. conicum comb. nov. as the generitype and Parvicellularium gen. nov. (subfamily incertae sedis), with P. leonardi sp. nov. as the generitype. Chamberlainoideae has no diagnostic morpho-anatomical features that enable one to assign specimens to it without DNA sequence data, and it is the first subfamily to possess both Type 1 (Chamberlainium) and Type 2 (Pneophyllum) tetra/bisporangial conceptacle roof development. Two characters distinguish Chamberlainium from Spongites: tetra/biasporangial conceptacle chamber diameter (300 μm in Spongites) and tetra/bisporangial conceptacle roof thickness (8 cells in Spongites). Two characters also distinguish Pneophyllum from Dawsoniolithon: tetra/bisporangial conceptacle roof thickness (8 cells in Dawsoniolithon) and thallus construction (dimerous in Pneophyllum vs. monomerous in Dawsoniolithon). This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

  12. A Novel Role of Human Holliday Junction Resolvase GEN1 in the Maintenance of Centrosome Integrity

    DEFF Research Database (Denmark)

    Gao, M.; Danielsen, Jannie Michaela Rendtlew; Wei, L.-Z.

    2012-01-01

    but not catalytic activity of GEN1 is required for preventing centrosome hyper-amplification, formation of multiple mitotic spindles, and multi-nucleation. Our findings provide novel insight into the biological functions of GEN1 by uncovering an important role of GEN1 in the regulation of centrosome integrity....

  13. Optimal trading strategy for GenCo in LMP-based and bilateral ...

    African Journals Online (AJOL)

    cboonchu

    GenCo) ... In Li and Shahidehpour (2005), a game-based bidding strategy for GenCos with ..... With the different demands, dispatched levels of GenCos vary as shown in Table 6. .... optimisation, AI applications to power systems, and power system ...

  14. GenBank blastn search result: AK064582 [KOME

    Lifescience Database Archive (English)

    Full Text Available AK064582 002-112-F03 AY007820.1 Daucus carota ATPase8 (ATP8) gene, ATP8-Sp1b allele, complete cds; chimeric... ATPase9 (ATP9) gene, ATP9-Sp3 allele, complete cds; and chimeric ATPase6 (ATP6) gen

  15. Safer Systems: A NextGen Aviation Safety Strategic Goal

    Science.gov (United States)

    Darr, Stephen T.; Ricks, Wendell R.; Lemos, Katherine A.

    2008-01-01

    The Joint Planning and Development Office (JPDO), is charged by Congress with developing the concepts and plans for the Next Generation Air Transportation System (NextGen). The National Aviation Safety Strategic Plan (NASSP), developed by the Safety Working Group of the JPDO, focuses on establishing the goals, objectives, and strategies needed to realize the safety objectives of the NextGen Integrated Plan. The three goal areas of the NASSP are Safer Practices, Safer Systems, and Safer Worldwide. Safer Practices emphasizes an integrated, systematic approach to safety risk management through implementation of formalized Safety Management Systems (SMS) that incorporate safety data analysis processes, and the enhancement of methods for ensuring safety is an inherent characteristic of NextGen. Safer Systems emphasizes implementation of safety-enhancing technologies, which will improve safety for human-centered interfaces and enhance the safety of airborne and ground-based systems. Safer Worldwide encourages coordinating the adoption of the safer practices and safer systems technologies, policies and procedures worldwide, such that the maximum level of safety is achieved across air transportation system boundaries. This paper introduces the NASSP and its development, and focuses on the Safer Systems elements of the NASSP, which incorporates three objectives for NextGen systems: 1) provide risk reducing system interfaces, 2) provide safety enhancements for airborne systems, and 3) provide safety enhancements for ground-based systems. The goal of this paper is to expose avionics and air traffic management system developers to NASSP objectives and Safer Systems strategies.

  16. An electronic flight bag for NextGen avionics

    Science.gov (United States)

    Zelazo, D. Eyton

    2012-06-01

    The introduction of the Next Generation Air Transportation System (NextGen) initiative by the Federal Aviation Administration (FAA) will impose new requirements for cockpit avionics. A similar program is also taking place in Europe by the European Organisation for the Safety of Air Navigation (Eurocontrol) called the Single European Sky Air Traffic Management Research (SESAR) initiative. NextGen will require aircraft to utilize Automatic Dependent Surveillance-Broadcast (ADS-B) in/out technology, requiring substantial changes to existing cockpit display systems. There are two ways that aircraft operators can upgrade their aircraft in order to utilize ADS-B technology. The first is to replace existing primary flight displays with new displays that are ADS-B compatible. The second, less costly approach is to install an advanced Class 3 Electronic Flight Bag (EFB) system. The installation of Class 3 EFBs in the cockpit will allow aircraft operators to utilize ADS-B technology in a lesser amount of time with a decreased cost of implementation and will provide additional benefits to the operator. This paper describes a Class 3 EFB, the NexisTM Flight-Intelligence System, which has been designed to allow users a direct interface with NextGen avionics sensors while additionally providing the pilot with all the necessary information to meet NextGen requirements.

  17. Justicia y genética: compensando las diferencias

    Directory of Open Access Journals (Sweden)

    Alejandra Zúñiga-Fajuri

    2013-01-01

    Full Text Available Se analizan los dilemas morales asociados a los avances científicos que en la actualidad nos exigen repensar el concepto de igualdad equitativa de oportunidades. Asimismo, se pasa revista a la discusión filosófica en torno al origen de las desventajas sociales y genéticas que permiten las desigualdades sociales.

  18. Distributed Generation Market Demand Model (dGen): Documentation

    Energy Technology Data Exchange (ETDEWEB)

    Sigrin, Benjamin [National Renewable Energy Lab. (NREL), Golden, CO (United States); Gleason, Michael [National Renewable Energy Lab. (NREL), Golden, CO (United States); Preus, Robert [National Renewable Energy Lab. (NREL), Golden, CO (United States); Baring-Gould, Ian [National Renewable Energy Lab. (NREL), Golden, CO (United States); Margolis, Robert [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2016-02-01

    The Distributed Generation Market Demand model (dGen) is a geospatially rich, bottom-up, market-penetration model that simulates the potential adoption of distributed energy resources (DERs) for residential, commercial, and industrial entities in the continental United States through 2050. The National Renewable Energy Laboratory (NREL) developed dGen to analyze the key factors that will affect future market demand for distributed solar, wind, storage, and other DER technologies in the United States. The new model builds off, extends, and replaces NREL's SolarDS model (Denholm et al. 2009a), which simulates the market penetration of distributed PV only. Unlike the SolarDS model, dGen can model various DER technologies under one platform--it currently can simulate the adoption of distributed solar (the dSolar module) and distributed wind (the dWind module) and link with the ReEDS capacity expansion model (Appendix C). The underlying algorithms and datasets in dGen, which improve the representation of customer decision making as well as the spatial resolution of analyses (Figure ES-1), also are improvements over SolarDS.

  19. Meet Mr. and Mrs. Gen X: A New Parent Generation

    Science.gov (United States)

    Howe, Neil

    2010-01-01

    Slowly but surely, Generation Xers have been taking over from Baby Boomers as the majority of parents in elementary and secondary education. In the early 1990s, Gen Xers began joining parent-teacher associations in the nation's elementary schools. Around 2005, they became the majority of middle school parents. By the fall of 2008, they took over…

  20. PowerGen plc report and accounts 1994

    International Nuclear Information System (INIS)

    1994-01-01

    The annual report and accounts of PowerGen plc for the year 1994 are presented. Financial highlights are quoted, followed by the Chairman's statement, reviews by the Chief Executive and Financial Directors, reports by the Auditors and Directors, balance sheets and details of the consolidated profit and loss account and principal accounting policies. A four year summary and shareholder information are included. (UK)

  1. A New Parent Generation: Meet Mr. and Mrs. Gen X

    Science.gov (United States)

    Howe, Neil

    2010-01-01

    Slowly but surely, Generation Xers have been taking over from Baby Boomers as the majority of parents in elementary and secondary education. Gen-X parents and Boomer parents belong to two neighboring generations, each possessing its own location in history and its own peer personality. They are similar in some respects, but clearly different in…

  2. GenSVM: a generalized multiclass support vector machine

    NARCIS (Netherlands)

    G.J.J. van den Burg (Gertjan); P.J.F. Groenen (Patrick)

    2016-01-01

    textabstractTraditional extensions of the binary support vector machine (SVM) to multiclass problems are either heuristics or require solving a large dual optimization problem. Here, a generalized multiclass SVM is proposed called GenSVM. In this method classification boundaries for a K-class

  3. U.S. Level III and IV Ecoregions (U.S. EPA)

    Data.gov (United States)

    U.S. Environmental Protection Agency — This map service displays Level III and Level IV Ecoregions of the United States and was created from ecoregion data obtained from the U.S. Environmental Protection...

  4. Uruguay; 2011 Article IV Consultation

    OpenAIRE

    International Monetary Fund

    2011-01-01

    This 2011 Article IV Consultation highlights that the growth momentum in Uruguay has continued into 2011 but a slowdown is under way, led by weaker exports and slower public investment. Uruguay’s economic and financial vulnerabilities are modest, and the government has reduced debt vulnerabilities significantly and built important financial buffers. Executive Directors have commended authorities’ skillful macroeconomic management that has underpinned Uruguay’s excellent economic performance, ...

  5. Austria; 2013 Article IV Consultation

    OpenAIRE

    International Monetary Fund

    2013-01-01

    This paper presents details of Austria’s 2013 Article IV Consultation. Austria has been growing economically but is facing challenges in the financial sector. Full implementation of medium-term fiscal adjustment plans require specifying several measures and plans that need gradual strengthening to take expected further bank restructuring cost into account. It suggests that strong early bank intervention and resolution tools, a better designed deposit insurance system, and a bank-financed reso...

  6. Pemotongan dan Menyambung DNA dalam Kloning Gen, Studi pada Kloning Gen Prolidase dari Bakteri Asam Laktat

    Directory of Open Access Journals (Sweden)

    Ketut Suriasih

    2015-03-01

    Full Text Available Gene cloning in lactic acid bacteria (LAB is crucial in term to increase their ability to hydrolyze milk protein such as proline. This proline could be hydrolyzed when the LAB undergone cloning on their genome coding the enzyme. The cloning process need technology to separate/isolate the gene capable of proline hydrolyze. Isolation of DNA containing prolidase gene, need DNA genome cutting. After isolation of DNA gene coding prolidase, it is then recombined with other bacterial DNA to obtained recombinant gene. The process need ligase. In gene cloning, knowledge of cutting and joining the DNA should be understood. The enzyme take the role in cutting and joining the DNA were restriction endonuclease and ligase. The restriction enzyme function (1 in inserting a gen into plasmid contained in a vector during gene cloning, and gene expression experiment, and (2 to identify the gene. It is important that the researcher already have standardized  sequenced gene as control. The DNA contained target gene was cut using some restriction enzyme, then the gene was arrayed in electrophoresis gel using southern blot technique. DNA sequence was elucidated by addition of ethydium bromide. To identify/characterize the isolated gene, this DNA sequence was encountered the control DNA.

  7. ASTRID, the SFR Gen IV technology demonstrator project: where are we, where do we stand for? - 15439

    International Nuclear Information System (INIS)

    Rouault, J.; Abonneau, E.; Settimo, D.; Hamy, J.M.; Hayafune, H.; Gefflot, R.; Benard, R.P.; Mandement, O.; Chauveau, T.; Lambert, G.; Audouin, P.; Mochida, H.; Iitsuka, T.; Fukuie, M; Molyneux, J.; Mazel, J.L.

    2015-01-01

    The Preconceptual Design phase (AVP1) of the ASTRID Project ended late 2012, the main goal was to evaluate innovative options. It is now followed by the AVP2 phase planned until the end of 2015 whose objectives are both to focus the design in order to finalize a coherent reactor outline and to finalize by December 2015 the Safety Option Report. The CEA acts as the industrial architect of the project. In 2014, twelve industrial partners were involved in the project. Japan which participates now in the design studies and also in Research/Development in support of the ASTRID Project and VELAN of the French 'Pole Nucleaire de Bourgogne', are the latest partners to join the Project. The Option Selection Process (RCO) is continuing during the AVP2 phase although structuring decisions remain to be made (the choice of the Energy Conversion System between Rankine cycle and Gas Brayton cycle). Other important option selections, which could nevertheless be reconsidered before starting the core of the Basic Design phase are: the choice of an internal fuel storage and a gas fuel handling chain, a rectangular reactor building with a single wall containment, the steam generator size the vertical handling of components. In addition, BOP studies considering the Marcoule site as a possible one are going on. The next important milestone is at the end of 2015 with the release by the Project team of a convincing and coherent Conceptual Design file. (authors)

  8. New RELAP5-3D Lead and LBE Thermophysical Properties Implementation for Safety Analysis of Gen IV Reactors

    Directory of Open Access Journals (Sweden)

    P. Balestra

    2016-01-01

    Full Text Available The latest versions of RELAP5-3D© code allow the simulation of thermodynamic system, using different type of working fluids, that is, liquid metals, molten salt, diathermic oil, and so forth, thanks to the ATHENA code integration. The RELAP5-3D© water thermophysical properties are largely verified and validated; however there are not so many experiments to generate the liquid metals ones in particular for the Lead and the Lead Bismuth Eutectic. Recently, new and more accurate experimental data are available for liquid metals. The comparison between these state-of-the-art data and the RELAP5-3D© default thermophysical properties shows some discrepancy; therefore a tool for the generation of new properties binary files has been developed. All the available data came from experiments performed at atmospheric pressure. Therefore, to extend the pressure domain below and above this pressure, the tool fits a semiempirical model (soft sphere model with inverse-power-law potential, specific for the liquid metals. New binary files of thermophysical properties, with a detailed mesh grid of point to reduce the code mass error (especially for the Lead, were generated with this tool. Finally, calculations using a simple natural circulation loop were performed to understand the differences between the default and the new properties.

  9. Thermodynamic Data to Model the Interaction Between Coolant and Fuel in Gen IV Sodium Cooled Fast Reactors

    International Nuclear Information System (INIS)

    Dinsdale, Alan; Gisby, John; Davies, Hugh; Konings, Rudy; Benes, Ondrej

    2013-06-01

    Understanding the behaviour of nuclear fuels in various environments is vital to the design and safe operation of nuclear reactors. While this is true if the reactor is operating within its design specification, it is even more so if accidents occur and the fuel is exposed to unexpected temperatures, pressures or chemical environments. It is clearly hazardous and costly to explore all such scenarios experimentally and therefore it is necessary to undertake modelling where possible using well-grounded theoretical approaches. This paper will show examples of where calculations of chemical and phase equilibria have been applied successfully to the long term storage of nuclear waste, phase formation during core meltdown and prediction of fission product release into the atmosphere. It will also highlight the development of thermodynamic data carried out during the European Metrology Research Project Metrofission required to model the potential interaction between the coolant, nuclear fuel, containment materials and atmosphere of a sodium cooled fast reactor. (authors)

  10. Identificación de mutaciones puntuales del gen de la 21-hidroxilasa en pacientes afectados con hiperplasia suprarrenal congénita.

    Directory of Open Access Journals (Sweden)

    Dora Fonseca

    2005-06-01

    Full Text Available lntroducción. La hiperplasia suprarrenal congénita es un trastorno autosómico recesivo debido a la inadecuada secreción de cortisol. Mas del 95% de los casos de hiperplasia suprarrenal congénita son causados por defectos del gen de la 21 hidroxilasa, CYP21A2 . Las manifestaciones clínicas incluyen la forma clásica y la forma no clásica. Objetivos. Determinar la frecuencia de las mutaciones puntuales P30L, IVS2-12AIC-G, Del 8pb, I172N, cluster Ex 6, V281L, Q318X, R356W y P453S en pacientes con hiperplasia suprarrenal congénita. Materiales y métodos. Se estudiaron 58 pacientes, de los cuales, 48 fueron clásicos y 10 no clásicos. Mediante PCR alelo-especifica y ACRS (Amplified Creation Restriction Sites, se analizaron 9 mutaciones puntuales del gen CYP21A2 y se determinó la frecuencia en la población analizada. Resultados. Los alelos afectados se identificaron en el 82,8% de los cromosomas. Las mutaciones mas frecuentes fueron: IVS2-12AIC-G (26,7%, Q318X (21,5%, V281L (12,1% e I172N (12,1%. Conclusiones. Las mutaciones mas frecuentes en Colombia son similares a las de otros países del mundo, excepto para Q318X que presentó una mayor frecuencia, pero similar a la de otros países latinoamericanos. Este hallazgo y la existencia de 17,2% de alelos no identificados puede indicar diferencia entre el acervo genético de las poblaciones. En la forma clásica perdedora de sal predominaron las mutaciones Q318X e IVS2-12AIC-G; en la virilizante simple, IVS2-12AIC-G e I172N y en la no clásica , V281L, lo cual esta relacionado con el grado de actividad enzimática. En la forma no clásica, se encontraron alelos severos en el 66,7% de los casos, lo que determina el riesgo de tener hijos afectados con la forma grave virilizante simple o perdedora de sal. Los resultados reportados permiten ofrecer asesoramiento genético y diagnóstico prenatal.

  11. The PHEDEx next-gen website

    CERN Document Server

    Wildish, Anthony

    2012-01-01

    PhEDEx is the data-transfer management solution written by CMS. It consists of agents running at each site, a website for presentation of information, and a web-based data-service for scripted access to information. The website allows users to monitor the progress of data-transfers, the status of site agents and links between sites, and the overall status and behaviour of everything about PhEDEx. It also allows uses to make and approve requests for data-transfers and for deletion of data. It is the main point-of-entry for all users wishing to interact with PhEDEx. For several years, the website has consisted of a single perl program with about 10K SLOC. This program has limited capabilities for exploring the data, with only coarse filtering capabilities and no context-sensitive awareness. Graphical information is presented as static images, generated on the server, with no interactivity. It is also not well connected to the rest of the PhEDEx codebase, since much of it was written before the data-service wa...

  12. Justicia en salud y genética

    Directory of Open Access Journals (Sweden)

    Maria Graciela De Ortuzar

    2014-06-01

    Full Text Available Las expectativas puestas en el conocimiento genético exceden el ámbito de la medicina tradiciona, debido a que la intervención directa en la lotería natural demandaría el replanteamiento de conceptos centrales de justicia en salud: necesidades médicas, enfermedad, normalidad, e igualdad de oportunidades en el acceso a la salud. El punto en debate es sí el replanteo de dichos conceptos conlleva un cambio radical en las teorías de justicia (libertariana y/o liberal, mostrando su obsolescencia, o sí simplemente se requiere ampliar dichos conceptos claves por fallas estructurales en las mismas teorías. Como hipótesis general considero que los supuestos cuestionamientos, lejos de socavar las bases de las teorías de justicia, sólo ponen en evidencia sus viejos problemas estructurales. Por razones expositivas, dividiré la presentación tres partes. En la Primera parte, analizo la teoría libertariana, estudiando las contradicciones del modelo a través del impacto de la información genética en el seguro privado de salud. En la Segunda Parte, desarrollo la propuesta alternativa liberal rawlsianadanielsiana del modelo de seguro público, evaluando las implicaciones de la genética a partir de la crítica de su concepto biológico de enfermedad y su restricción al acceso a la salud por necesidades naturales. En la Tercera parte presento un modelo integral de necesidades y capacidades básicas, comprendiendo la prevención, el tratamiento y el mejoramiento moralmente permisible (genético y no genético.Mi aporte principal consiste en la elaboración de este modelo normativo integral de necesidades y capacidades para la regulación conjunta de la información y terapia genética con los restantes problemas de salud.

  13. Perda auditiva genética Genetic hearing loss

    Directory of Open Access Journals (Sweden)

    Ricardo Godinho

    2003-01-01

    Full Text Available O progresso das pesquisas relacionadas à perda auditiva genética tem provocado um importante avanço do entendimento dos mecanismos moleculares que governam o desenvolvimento, a função, a resposta ao trauma e o envelhecimento do ouvido interno. Em países desenvolvidos, mais de 50% dos casos de surdez na infância é causada por alterações genéticas e as perdas auditivas relacionadas à idade têm sido associadas com mecanismos genéticos. OBJETIVO: O objetivo desta revisão é relatar as informações mais recentes relacionadas às perdas audtivas de origem genética. FORAMA DE ESTUDO: Revisão sistemática. MATERIAL E MÉTODO: A revisão da literatura inclui artigos indexados à MEDLINE (Biblioteca Nacional de Saúde, NIH-USA e publicados nos últimos 3 anos, além das informações disponíveis na Hereditary Hearing Loss Home Page. CONCLUSÃO: Os recentes avanços no entendimento das perdas auditivas de origem genética têm favorecido a nossa compreensão da função auditiva e tornado o diagnóstico mais apurado. Possivelmente, no futuro, este conhecimento também proporcionará o desenvolvimento de novas terapias para o tratamento das causas genéticas das perdas auditivas.The progress in the research of genetic hearing loss has advanced our understanding of the molecular mechanisms that govern inner ear development, function and response to injury and aging. In the developed world, over 50% of childhood deafness is attributable to genetic causes and even age-related hearing loss has been associated with genetic mechanisms. AIM: The objective of this review is to summarize recent knowledge in genetic hearing loss. STUDY DESIGN: Sistematic review. MATERIAL AND METHODS: The literature review included articles indexed at MEDLINE (The National Library of Medicine, The National Institute of Health - USA focusing on publications from the past 3 years plus the information available at the Hereditary Hearing Loss Home Page. CONCLUSION

  14. FINAL DESIGN REVIEW REPORT Subcritical Experiments Gen 2, 3-ft Confinement Vessel Weldment

    Energy Technology Data Exchange (ETDEWEB)

    Romero, Christopher [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2017-09-28

    A Final Design Review (FDR) of the Subcritical Experiments (SCE) Gen 2, 3-ft. Confinement Vessel Weldment was held at Los Alamos National Laboratory (LANL) on September 14, 2017. The review was a focused review on changes only to the confinement vessel weldment (versus a system design review). The changes resulted from lessons-learned in fabricating and inspecting the current set of confinement vessels used for the SCE Program. The baseline 3-ft. confinement vessel weldment design has successfully been used (to date) for three (3) high explosive (HE) over-tests, two (2) fragment tests, and five (5) integral HE experiments. The design team applied lessons learned from fabrication and inspection of these vessel weldments to enhance fit-up, weldability, inspection, and fitness for service evaluations. The review team consisted of five (5) independent subject matter experts with engineering design, analysis, testing, fabrication, and inspection experience. The

  15. Crystalline cerium(IV) phosphates

    International Nuclear Information System (INIS)

    Herman, R.G.; Clearfield, A.

    1976-01-01

    The ion exchange behaviour of seven crystalline cerium(IV) phosphates towards some of the alkali metal cations is described. Only two of the compounds (A and C) possess ion exchange properties in acidic solutions. Four others show some ion exchange characteristics in basic media with some of the alkali cations. Compound G does not behave as an ion exchanger in solutions of pH + , but show very little Na + uptake. Compound E undergoes ion exchange with Na + and Cs + , but not with Li+. Both Li + and Na + are sorbed by compounds A and C. The results are indicative of structures which show steric exclusion phenomena. (author)

  16. PREPARATION OF OXOPORPHINATOMANGANESE (IV) COMPLEX

    Energy Technology Data Exchange (ETDEWEB)

    Willner, I.; Otvos, J.; Calvin, M.

    1980-07-01

    Oxo-manganese-tetraphenylporphyrin (O=Mn{sup IV}-TPP) has been prepared by an oxygen-transfer reaction from iodosylbenzene to MnIITPP and characterized by its i.r. and field desorption mass spectra, which are identical to those of the product obtained by direct oxidation of Mn{sup III}(TPP) in an aqueous medium; it transfers oxygen to triphenylphosphine to produce triphenylphosphine oxide, and it is suggested that similar intermediates are important in oxygen activation by cytochrome P-450 as well as in the photosynthetic evolution of oxygen.

  17. Norway; Staff Report for the 2001 Article IV Consultation

    OpenAIRE

    International Monetary Fund

    2002-01-01

    This 2001 Article IV Consultation highlights that the real mainland (non-oil) GDP of Norway is estimated to have grown well below potential in 2001, at 1¼ percent. Although high oil prices supported household confidence and domestic activity through most of the year, the global slowdown has recently begun to affect Norway. Labor market conditions remain tight in service sectors, but weakened in technology and traditional export industries. Despite high domestic cost increases, consumer price ...

  18. Luxembourg; Staff Report for the 2015 Article IV Consultation

    OpenAIRE

    International Monetary Fund

    2015-01-01

    This 2015 Article IV Consultation highlights that Luxembourg’s economic model, emphasizing fiscal stability, openness, firm prudential oversight, and responsiveness to investor needs, is delivering strong growth. Buoyant financial services exports contributed to real growth of close to 3 percent in 2014, with strong job creation. Budget 2015 launched a multi-year fiscal consolidation aimed at offsetting falling revenues from electronic commerce. The economy faces important challenges going fo...

  19. Genética e hanseníase

    OpenAIRE

    Beiguelman Bernardo

    2002-01-01

    As diferentes linhas de pesquisa utilizadas para investigar a importância dos fatores hereditários humanos na determinação da resistência/suscetibilidade à infecção pelo Mycobacterium leprae foram discutidas no presente trabalho. Uma síntese dessas abordagens permitiu analisar os resultados das investigações sobre associação da hanseníase com polimorfismos genéticos, distribuição familial da hanseníase, prevalência da hanseníase e distância genética, concordância da hanseníase em gêmeos e est...

  20. Análise de distância genética entre acessos do gênero Psidium via marcadores ISSR

    Directory of Open Access Journals (Sweden)

    Názila Nayara Silva de Oliveira

    2014-12-01

    Full Text Available O objetivo deste trabalho foi avaliar a distância genética entre 37 acessos da espécie cultivada Psidium guajava, L. (goiaba e de araçás do gênero Psidium do banco de germoplasma da Universidade Estadual do Norte Fluminense (UENF, via marcadores moleculares ISSR. Nos 17 marcadores selecionados, foram obtidas 216 bandas polimórficas. Pelo método de agrupamento UPGMA, houve a formação de cinco principais grupos. Os acessos de araçá da espécie P. cattleyanum Sabine , ficaram alocados nos grupos I e II. No grupo II, foi observada, dentro da espécie P cattleyanum, maior proximidade com a goiabeira. No grupo III, ficou alocado o acesso da espécie P. guineense Sw (araçá-do-campo e dentre os araçás, foi o que ficou mais próximo da goiaba. Os genótipos de goiabeira ficaram alocados do grupo IV e V, confirmando sua alta divergência. Os marcadores moleculares foram eficientes em estimar a distância genética intra e interespecífica.

  1. Estructura y diversidad genética en vacas Holstein de Antioquia usando un polimorfismo del gen bGH

    Directory of Open Access Journals (Sweden)

    Juan Rincon F.

    2013-03-01

    Full Text Available Objetivo. Determinar las frecuencias alélicas y genotípicas del polimorfismo del intrón 3 del gen bGH y estimar algunos parámetros de estructura poblacional en ganado Holstein. Materiales y métodos. El estudio se realizó con 1366 vacas Holstein en 120 hatos de 11 municipios del departamento de Antioquia. Se extrajo DNA por el método de Salting out y la genotipificación se realizó usando la técnica de PCR-RFLPs. La diversidad genética se determinó mediante la comparación de las heterocigosidades, El equilibrio de Hardy-Weinberg (HW y la diferenciación genética entre las poblaciones se realizó usando el software Arlequín 2.0 Las frecuencias alélicas y genotípicas se evaluaron mediante el paquete estadístico SAS®. Resultados. Las frecuencias genotípicas encontradas fueron 0.764 (+/+, 0.223 (+/- y 0.013 (-/- y las frecuencias alélicas 0.876 (+ y 0.124 (-. No se encontraron desviaciones del Equilibrio de Hardy Weinberg en ninguna de las subpoblaciones. La diversidad genética determinada mediante la comparación de las heterocigosidades fue relativamente baja entre poblaciones pero al interior de estas no. El valor de FST de toda la población fue de 0.0068 y significativo (p<0.05, algunos FST pareados también lo fueron, tomando valores desde 0.0 a 0.13. Los estadísticos FIT y FIS no fueron significativos. Conclusiones. El gen bGH es un candidato interesante para evaluar características de importancia económica ya que no parece haber sido sometido a selección directa, presenta una variabilidad media en las poblaciones, observándose diferenciación genética significativa entre distintos municipios, producto de los diferentes sistemas de producción y acceso a las biotecnologías.

  2. Test Review: Advanced Clinical Solutions for WAIS-IV and WMS-IV

    Science.gov (United States)

    Chu, Yiting; Lai, Mark H. C.; Xu, Yining; Zhou, Yuanyuan

    2012-01-01

    The authors review the "Advanced Clinical Solutions for WAIS-IV and WMS-IV". The "Advanced Clinical Solutions (ACS) for the Wechsler Adult Intelligence Scale-Fourth Edition" (WAIS-IV; Wechsler, 2008) and the "Wechsler Memory Scale-Fourth Edition" (WMS-IV; Wechsler, 2009) was published by Pearson in 2009. It is a…

  3. Crusticorallina gen. nov., a nongeniculate genus in the subfamily Corallinoideae (Corallinales, Rhodophyta).

    Science.gov (United States)

    Hind, Katharine R; Gabrielson, Paul W; P Jensen, Cassandra; Martone, Patrick T

    2016-12-01

    Molecular phylogenetic analyses of 18S rDNA (SSU) gene sequences confirm the placement of Crusticorallina gen. nov. in Corallinoideae, the first nongeniculate genus in an otherwise geniculate subfamily. Crusticorallina is distinguished from all other coralline genera by the following suite of morpho-anatomical characters: (i) sunken, uniporate gametangial and bi/tetrasporangial conceptacles, (ii) cells linked by cell fusions, not secondary pit connections, (iii) an epithallus of 1 or 2 cell layers, (iv) a hypothallus that occupies 50% or more of the total thallus thickness, (v) elongate meristematic cells, and (vi) trichocytes absent. Four species are recognized based on rbcL, psbA and COI-5P sequences, C. painei sp. nov., the generitype, C. adhaerens sp. nov., C. nootkana sp. nov. and C. muricata comb. nov., previously known as Pseudolithophyllum muricatum. Type material of Lithophyllum muricatum, basionym of C. muricata, in TRH comprises at least two taxa, and therefore we accept the previously designated lectotype specimen in UC that we sequenced to confirm its identity. Crusticorallina species are very difficult to distinguish using morpho-anatomical and/or habitat characters, although at specific sites, some species may be distinguished by a combination of morpho-anatomy, habitat and biogeography. The Northeast Pacific now boasts six coralline endemic genera, far more than any other region of the world. © 2016 Phycological Society of America.

  4. NextGen Avionics Roadmap Version 2.0

    Science.gov (United States)

    2011-09-30

    Systems Analysis ( IPSA ) Division has defined multiple NextGen Operational (NGOps) Levels, projecting relative performance and risk based on differing...degrees of capability improvements, as shown in Figure 4. IPSA forecasts include the most likely performance NGOps level (i.e., NGOps 3-4), as well...in the near-term. Figures 5 through 9 de- pict the various programs and capabilities aligned with the various NGOps levels. Factors from the IPSA

  5. EVALUATION DE LA SENSIBILITE A Bemisia tabaci (GEN) DE 13 ...

    African Journals Online (AJOL)

    AISA

    champ, le comportement de 13 variétés de tomate contre la pression de Bemisia tabaci (Gen), une mouche vecteur du virus de la jaunisse en cuillère des ... en saison sèche il y a une vingtaine d'années atteignaient 100 % et les pertes de production ... semaines. Le semis s'est effectué sur une planche de 9 m2 (9 x 1 m2).

  6. NOMAGE4 activities 2011. Part I, Nordic Nuclear Materials Forum for Generation IV Reactors: Status and activities in 2011

    International Nuclear Information System (INIS)

    Van Nieuwenhove, R.

    2012-01-01

    A network for materials issues has been initiated in 2009 within the Nordic countries. The original objectives of the Generation IV Nordic Nuclear Materials Forum (NOMAGE4) were to form the basis of a sustainable forum for Gen-IV issues, especially focusing on fuels, cladding, structural materials and coolant interaction. Over the last years, other issues such as reactor physics, thermal hydraulics, safety and waste have gained in importance (within the network) and therefore the scope of the forum has been enlarged and a more appropriate and more general name, NORDIC-GEN4, has been chosen for the forum. Further, the interaction with non-Nordic countries (such as The Netherlands (JRC, NRG) and Czech Republic (CVR)) will be increased. Within the NOMAGE4 project, a seminar was organized by IFE-Halden during 31 October - 1 November 2011. The seminar attracted 65 participants from 12 countries. The seminar provided a forum for exchange of information, discussion on future research reactor needs and networking of experts on Generation IV reactor concepts. The participants could also visit the Halden reactor site and the workshop. (Author)

  7. NOMAGE4 activities 2011. Part I, Nordic Nuclear Materials Forum for Generation IV Reactors: Status and activities in 2011

    Energy Technology Data Exchange (ETDEWEB)

    Van Nieuwenhove, R. (Institutt for Energiteknikk, OECD Halden Reactor Project (Norway))

    2012-01-15

    A network for materials issues has been initiated in 2009 within the Nordic countries. The original objectives of the Generation IV Nordic Nuclear Materials Forum (NOMAGE4) were to form the basis of a sustainable forum for Gen-IV issues, especially focusing on fuels, cladding, structural materials and coolant interaction. Over the last years, other issues such as reactor physics, thermal hydraulics, safety and waste have gained in importance (within the network) and therefore the scope of the forum has been enlarged and a more appropriate and more general name, NORDIC-GEN4, has been chosen for the forum. Further, the interaction with non-Nordic countries (such as The Netherlands (JRC, NRG) and Czech Republic (CVR)) will be increased. Within the NOMAGE4 project, a seminar was organized by IFE-Halden during 31 October - 1 November 2011. The seminar attracted 65 participants from 12 countries. The seminar provided a forum for exchange of information, discussion on future research reactor needs and networking of experts on Generation IV reactor concepts. The participants could also visit the Halden reactor site and the workshop. (Author)

  8. SALOME PLATFORM and TetGen for Polyhedral Mesh Generation

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Sang Yong; Park, Chan Eok; Kim, Shin Whan [KEPCO E and C Company, Inc., Daejeon (Korea, Republic of)

    2014-05-15

    SPACE and CUPID use the unstructured mesh and they also require reliable mesh generation system. The combination of CAD system and mesh generation system is necessary to cope with a large number of cells and the complex fluid system with structural materials inside. In the past, a CAD system Pro/Engineer and mesh generator Pointwise were evaluated for this application. But, the cost of those commercial CAD and mesh generator is sometimes a great burden. Therefore, efforts have been made to set up a mesh generation system with open source programs. The evaluation of the TetGen has been made in focusing the application for the polyhedral mesh generation. In this paper, SALOME will be evaluated for the efforts in conjunction with TetGen. In section 2, review will be made on the CAD and mesh generation capability of SALOME. SALOME and TetGen codes are being integrated to construct robust polyhedral mesh generator. Edge removal on the flat surface and vertex reattachment to the solid are two challenging tasks. It is worthwhile to point out that the Python script capability of the SALOME should be fully utilized for the future investigation.

  9. The GenABEL Project for statistical genomics.

    Science.gov (United States)

    Karssen, Lennart C; van Duijn, Cornelia M; Aulchenko, Yurii S

    2016-01-01

    Development of free/libre open source software is usually done by a community of people with an interest in the tool. For scientific software, however, this is less often the case. Most scientific software is written by only a few authors, often a student working on a thesis. Once the paper describing the tool has been published, the tool is no longer developed further and is left to its own device. Here we describe the broad, multidisciplinary community we formed around a set of tools for statistical genomics. The GenABEL project for statistical omics actively promotes open interdisciplinary development of statistical methodology and its implementation in efficient and user-friendly software under an open source licence. The software tools developed withing the project collectively make up the GenABEL suite, which currently consists of eleven tools. The open framework of the project actively encourages involvement of the community in all stages, from formulation of methodological ideas to application of software to specific data sets. A web forum is used to channel user questions and discussions, further promoting the use of the GenABEL suite. Developer discussions take place on a dedicated mailing list, and development is further supported by robust development practices including use of public version control, code review and continuous integration. Use of this open science model attracts contributions from users and developers outside the "core team", facilitating agile statistical omics methodology development and fast dissemination.

  10. Variabilidad genética en Prosopis ferox (Mimosaceae

    Directory of Open Access Journals (Sweden)

    Alicia D. Burghardt

    2004-01-01

    Full Text Available Prosopis ferox (Mimosaceae es una especie arbustiva o arbórea espinosa que se distribuye desde el Sur de Bolivia hasta el noroeste de la Argentina. En la provincia de Jujuy se encuentra a grandes alturas (entre los 2400 y los 3700 m s.m.. Existe una gran variabilidad morfológica, especialmente en cuanto a las dimensiones del fruto y la cantidad de semillas por fruto, ambas características importantes debido al uso de esta planta como forraje. Con el objeto de verificar si existe además variabilidad genética, se realizó un estudio electroforético de proteínas seminales de árboles procedentes de distintas localidades de la provincia de Jujuy. Los patrones polipeptídicos obtenidos por SDS-PAGE presentaron en total 26 bandas. Cada población se caracterizó por sus patrones de presencia-ausencia de bandas, habiéndose encontrado variabilidad intrapoblacional (polimorfismo en algunas de ellas, siendo otras genéticamente homogéneas. Los índices polimórficos en poblaciones de P. ferox son comparables a los obtenidos previamente en P. ruscifolia. La variabilidad genética interpoblacional hallada por medio del estudio electroforético de las proteínas seminales hace suponer la existencia de ecotipos

  11. Canada's largest co-gen project

    International Nuclear Information System (INIS)

    Salaff, S.

    2000-01-01

    In November 2000, the TransAlta Energy Corp. began construction on its $400 million natural gas fuelled cogeneration project in Sarnia Ontario. The Sarnia Regional Cogeneration Project (SRCP) is designed to integrate a new 440 MW cogeneration facility to be built at the Sarnia Division of Dow Chemicals Canada Inc. with nearby existing generators totaling 210 MW at Dow and Bayer Inc. At 650 MW, the new facility will rank as Canada's largest cogeneration installation. Commercial operation is scheduled for October 2002. TransAlta owns three natural gas fuelled cogeneration facilities in Ontario (in Ottawa, Mississauga and Windsor) totaling 250 MW. The cost of electric power in Ontario is currently controlled by rising natural gas prices and the supply demand imbalance. This balance will be significantly affected by the possible return to service of 2000 MW of nuclear generating capacity. The SRCP project was announced just prior to the Ontario Energy Competition Act of October 1998 which committed the province to introduce competition to the electricity sector and which created major uncertainties in the electricity market. Some of the small, 25 MW projects which survived the market uncertainty included the Toronto-based Toromont Energy Ltd. project involving gas fuelled cogeneration and methane gas generation from landfill projects in Sudbury and Waterloo. It was emphasized that cogeneration and combined heat and power projects have significant environmental advantages over large combined cycle facilities. The Ontario Energy Board is currently considering an application from TransAlta to link the SRCP facility to Ontario's Hydro One Network Inc.'s transmission grid. 1 fig

  12. Divergência, variabilidade genética e desempenho agronômico em genótipos de couve.

    OpenAIRE

    Azevedo, Alcinei Mistico

    2012-01-01

    Embora haja grande variabilidade genética para a couve, são poucos trabalhos no Brasil que visão obter informações para programas de melhoramento genético nesta cultura. Assim, objetivou-se neste trabalho caracterizar 30 genótipos de couve a partir de caracteres morfo-agronômicos para estimar a divergência genética, a importância dos caracteres para a divergência, o desempenho agronômico, os parâmetros genéticos e a correlação entre as características avaliadas. O experimento foi conduzido na...

  13. Crescimento de genótipos de frangos tipo caipira

    Directory of Open Access Journals (Sweden)

    R. C. Veloso

    2015-10-01

    Full Text Available RESUMOObjetivou-se com este trabalho comparar o padrão de crescimento, mediante ajustes das respectivas curvas de crescimento por modelos não lineares, bem como estudar o desenvolvimento de cortes de carcaça em relação ao peso da carcaça em diferentes genótipos de frangos tipo caipira. Foram utilizados 840 pintos de um dia, machos, distribuídos em delineamento inteiramente ao acaso, dos seguintes genótipos da linhagem Redbro: Caboclo, Carijó, Colorpak, Gigante Negro, Pesadão Vermelho, Pescoço Pelado e Tricolor. As aves foram alojadas em 28 boxes, sendo 30 aves/boxe, em galpão de alvenaria com acesso a um piquete de 45m², com quatro repetições. O peso corporal individual dos frangos foi medido ao nascer, aos 14, 28, 42, 56, 70 e 84 dias de idade. Para a determinação das curvas de crescimento do peso corporal das aves, os dados coletados foram avaliados por meio dos modelos não lineares: Brody, Gompertz, Logístico, Richards e von Bertalanffy. Foi empregado o PROC NLIN do SAS, utilizando-se o método interativo de Gauss-Newton. Os critérios usados para escolha do modelo de melhor ajuste da curva de crescimento foram o coeficiente de determinação, o desvio padrão assintótico, o desvio médio absoluto dos resíduos e o índice assintótico. As análises para obtenção dos coeficientes alométricos foram realizadas por meio do PROC GLM do SAS para os genótipos Carijó, Colorpak, Pesadão Vermelho, Pescoço Pelado e Tricolor. Foram avaliados os pesos da carcaça, do peito, das coxas, das sobrecoxas, das pernas e das asas das aves abatidas aos 85 dias de idade. Apenas as equações propostas por Gompertz, von Bertalanffy e Logístico atingiram a convergência, e o modelo proposto por von Bertalanffy foi o mais adequado para descrever o crescimento dos genótipos de frangos caipiras. Todos os cortes avaliados apresentaram crescimento tardio em relação ao peso da carcaça em genótipos de frangos tipo caipira.

  14. Some oxozirconium(IV) compounds

    Energy Technology Data Exchange (ETDEWEB)

    Paul, R C; Gupta, S K; Parmar, S S; Vasisht, S K [Punjab Univ., Chandigarh (India). Dept. of Chemistry

    1976-01-01

    Some new oxozirconium(IV) complexes, ZrO(An)/sub 2/, ZrO(Gly)/sub 2/, ZrO(HSal)/sub 2/, ZrO(HPth)/sub 2/, ZrO(Pic)/sub 2/(HPic)/sub 2/, and ZrO(Quin)/sub 2/(HQuin)/sub 2/ have been isolated from the reactions of ZrO(CH/sub 3/COO)/sub 2/CH/sub 3/COOH with anthranilic acid (HAn), glycine (HGly), salicylic acid (H/sub 2/Sal), phthalic acid (H/sub 2/Pth), picolinic acid (HPic), and 8-quinolinol (HQuin) respectively. Their important infrared bands and wherever possible molar conductance and molecular weight have been reported.

  15. 76 FR 52718 - Complaint About Postal Services

    Science.gov (United States)

    2011-08-23

    ... Pleadings III. Statutory Alternatives for Commission Action IV. Analysis and Written Determination V....C. 403(c). Id. at 12. II. Postal Service Pleadings On June 7, 2011, the Postal Service filed a...)(1)(B). \\8\\ The statute does not specify the precise nature of the proceedings. IV. Analysis and...

  16. J3Gen: A PRNG for Low-Cost Passive RFID

    Directory of Open Access Journals (Sweden)

    Jordi Herrera-Joancomartí

    2013-03-01

    Full Text Available Pseudorandom number generation (PRNG is the main security tool in low-cost passive radio-frequency identification (RFID technologies, such as EPC Gen2. We present a lightweight PRNG design for low-cost passive RFID tags, named J3Gen. J3Gen is based on a linear feedback shift register (LFSR configured with multiple feedback polynomials. The polynomials are alternated during the generation of sequences via a physical source of randomness. J3Gen successfully handles the inherent linearity of LFSR based PRNGs and satisfies the statistical requirements imposed by the EPC Gen2 standard. A hardware implementation of J3Gen is presented and evaluated with regard to different design parameters, defining the key-equivalence security and nonlinearity of the design. The results of a SPICE simulation confirm the power-consumption suitability of the proposal.

  17. Genetics Home Reference: glycogen storage disease type IV

    Science.gov (United States)

    ... Home Health Conditions Glycogen storage disease type IV Glycogen storage disease type IV Printable PDF Open All ... Javascript to view the expand/collapse boxes. Description Glycogen storage disease type IV (GSD IV) is an ...

  18. A cerium(IV)-carbon multiple bond

    Energy Technology Data Exchange (ETDEWEB)

    Gregson, Matthew; Lu, Erli; McMaster, Jonathan; Lewis, William; Blake, Alexander J.; Liddle, Stephen T. [Nottingham Univ. (United Kingdom). School of Chemistry

    2013-12-02

    Straightforward access to a cerium(IV)-carbene complex was provided by one-electron oxidation of an anionic ''ate'' cerium(III)-carbene precursor, thereby avoiding decomposition reactions that plague oxidations of neutral cerium(III) compounds. The cerium(IV)-carbene complex is the first lanthanide(IV)-element multiple bond and involves a twofold bonding interaction of two electron pairs between cerium and carbon. [German] Auf direktem Wege zu einem Cer(IV)-Carbenkomplex gelangt man durch die Einelektronenoxidation einer anionischen Carben-Cerat(III)-Vorstufe. So werden Zersetzungsprozesse vermieden, die die Oxidation neutraler Cer(III)-Verbindungen erschweren. Der Cer(IV)-Carbenkomplex enthaelt die erste Lanthanoid(IV)-Element-Mehrfachbindung; dabei binden Cer und Kohlenstoff ueber zwei Elektronenpaare.

  19. iväkoti Riemula

    OpenAIRE

    Alanko, Reetta; Ihanamäki, Katja

    2012-01-01

    Opinnäytetyössä kuvataan yleisesti päivähoidon kehitystä Suomessa sekä päivähoitoa yrittäjän näkökulmasta, tuoden esille sen tämän päivän haasteet ja mahdollisuudet. Työssä on pohdittu yhteistyön merkitystä kunnan kanssa ja sitä, miten kunta voi osaltaan joko rajoittaa tai edesauttaa yksityisen päivähoitoyrityksen toimintaa. Opinnäytetyössä kerrotaan teoriassa Päiväkoti Riemula nimisen, erityispäivähoitopalveluita tarjoavan yrityksen perustamiseen liittyvistä suunnitelmista. Suunnitelluss...

  20. Update History of This Database - GenLibi | LSDB Archive [Life Science Database Archive metadata

    Lifescience Database Archive (English)

    Full Text Available switchLanguage; BLAST Search Image Search Home About Archive Update History Data ...List Contact us GenLibi Update History of This Database Date Update contents 2014/03/25 GenLibi English archi...base Description Download License Update History of This Database Site Policy | Contact Us Update History of This Database - GenLibi | LSDB Archive ... ...ve site is opened. 2007/03/01 GenLibi ( http://gene.biosciencedbc.jp/ ) is opened. About This Database Data

  1. Seleção de genótipos parentais de acerola com base na divergência genética multivariada

    Directory of Open Access Journals (Sweden)

    CARPENTIERI-PÍPOLO VALÉRIA

    2000-01-01

    Full Text Available Este trabalho teve por objetivo identificar e selecionar genótipos parentais de acerola (Malpighia emarginata L. adequadas a programas de melhoramento genético. Nove caracteres quantitativos de maior importância agronômica foram usados para determinação da distância genética e formação de grupos similares de acessos. O agrupamento pelo método de Tocher, a partir das distâncias generalizadas de Mahalanobis, possibilitou a divisão de 14 genótipos em três grupos. Com base na divergência genética e no caráter agronômico-chave (teor de vitamina C, destacaram-se como mais promissores os cruzamentos dos genótipos: AM Mole pertencente ao grupo III, com os genótipos PR AM, N° 18, PR 17, PR 16, Eclipse, AM 22 e Dominga, todos pertencentes ao grupo I.

  2. Updated Generation IV Reactors Integrated Materials Technology Program Plan, Revision 2

    Energy Technology Data Exchange (ETDEWEB)

    Corwin, William R [ORNL; Burchell, Timothy D [ORNL; Halsey, William [Lawrence Livermore National Laboratory (LLNL); Hayner, George [Idaho National Laboratory (INL); Katoh, Yutai [ORNL; Klett, James William [ORNL; McGreevy, Timothy E [ORNL; Nanstad, Randy K [ORNL; Ren, Weiju [ORNL; Snead, Lance Lewis [ORNL; Stoller, Roger E [ORNL; Wilson, Dane F [ORNL

    2005-12-01

    The Department of Energy's (DOE's) Generation IV Nuclear Energy Systems Program will address the research and development (R&D) necessary to support next-generation nuclear energy systems. Such R&D will be guided by the technology roadmap developed for the Generation IV International Forum (GIF) over two years with the participation of over 100 experts from the GIF countries. The roadmap evaluated over 100 future systems proposed by researchers around the world. The scope of the R&D described in the roadmap covers the six most promising Generation IV systems. The effort ended in December 2002 with the issue of the final Generation IV Technology Roadmap [1.1]. The six most promising systems identified for next generation nuclear energy are described within the roadmap. Two employ a thermal neutron spectrum with coolants and temperatures that enable hydrogen or electricity production with high efficiency (the Supercritical Water Reactor - SCWR and the Very High Temperature Reactor - VHTR). Three employ a fast neutron spectrum to enable more effective management of actinides through recycling of most components in the discharged fuel (the Gas-cooled Fast Reactor - GFR, the Lead-cooled Fast Reactor - LFR, and the Sodium-cooled Fast Reactor - SFR). The Molten Salt Reactor (MSR) employs a circulating liquid fuel mixture that offers considerable flexibility for recycling actinides, and may provide an alternative to accelerator-driven systems. A few major technologies have been recognized by DOE as necessary to enable the deployment of the next generation of advanced nuclear reactors, including the development and qualification of the structural materials needed to ensure their safe and reliable operation. Accordingly, DOE has identified materials as one of the focus areas for Gen IV technology development.

  3. Extended analysis of Cu IV

    International Nuclear Information System (INIS)

    Meinders, E.; Uijlings, P.

    1980-01-01

    Wavelength data and classifications of 974 Cu IV lines in the region 750-1275 Angstroem are presented. Most of the lines have been classified as transitions from the previously unknown high even configurations 3d 7 5s and 3d 7 4d to 3d 7 4p. The configuration 3d 7 4d is seriously perturbed by 3d 6 4s 2 . The analysis resulted in the identification of 27 levels of 3d 7 5s and 113 levels of (3d 7 4d + 3d 6 4s 2 ) which are reported. The earlier published levels of 3d 7 4s and 3d 7 4p have to be shifted downward as a consequence of improved wavelength data. Radial paramter values, resulting from least-squares fits, are compared to Hartree-Fock values. The eigenvectors obtained in the parametric fitting are used to calculate transition probabilities in intermediate coupling. The relation between the observed intensities of the transitions 3d 7 4d-3d 7 4p and 3d 7 Ss-3d 7 4p is compared to the relation between theoretical values of the transition integrals obtained from Hartree-Fock calculations. A spectroscopic value for the ionization potentials is calculated from the 3d 7 ns configurations. (orig.)

  4. Studies of binary cerium(IV)-praseodymium(IV) and cerium(IV)-terbium(IV) oxides as pigments for ceramic applications

    International Nuclear Information System (INIS)

    Furtado, L.M.L.

    1991-01-01

    It was investigated a series of pigments of general composition Ce 1-x Pr x O 2 , and Ce x Tb y O 2 , exhibiting radish and brown colors, respectively, and high temperature stability. The pigments were obtained by dissolving appropriate amounts of the pure lanthanide oxides in acids and precipitating the rare earths as mixed oxalates, which were isolated and calcined under air, at 1000 0 C. X-Ray powder diffractograms were consistent with a cubic structure for the pigments. Magnetic susceptibility measurements, using Gouy method, indicated the presence of Pr(IV) ions in the Ce 1-x Pr x O 2 pigments and of Terbium predominantly as Tb(III) ions in the Ce-tb mixed oxides. A new method, based on suspension of solid samples in PVA-STB gels (STB = sodium tetradecaborate), was employed for the measurements of the electronic spectra of the pigments. The thermal behaviour the pigments was investigated by the calcination of the oxalates in the temperature range of 500 to 1200 O C, from 10 to 60 minutes. (author)

  5. Distancias genéticas en poblaciones del NOA

    Directory of Open Access Journals (Sweden)

    Acreche, Noemí

    1996-01-01

    Full Text Available La mayor parte de los trabajos realizados en nuestro país sobre polimorfismos hematológicos, abordan la necesaria descripción de las poblaciones. Se pone de relieve la importancia de encarar estudios, en base a la valiosa información publicada, que vinculen los grupos con técnicas que permitan realizar nuevas inferencias sobre sus relaciones. Conocidas en gran medida en cuanto a sus manifestaciones culturales, pueden aportar desde lo genético a la comprensión de los procesos microevolutivos ocurridos en una región. Para el NOA, se ha considerado la presencia de comunidades aborígenes incluídas en cuatro familias lingüísticas. Se tendrán en cuenta estos complejos como representativos de afinidades que se establecen a partir de estrechas relaciones entre las etnias, no sólo por la lengua, sino también por las características de sus sistemas productivos, religiosidad y organización. En base a las frecuencias génicas publicadas correspondientes a los siguientes alelos: I*A, I*B, I*O; M, N, S, s; Dia , Dib; P1, P2; C, c; D, d, E, e; Le, le; Fya, Fyb; Jka, Jkb; K y k se construyeron tablas de frecuencias. Se estimaron los coeficientes de distancias genéticas que fueron analizados y posteriormente incluídos en la construcción de un fenograma de los grupos de estudio, mediante agrupaciones (Sahn Cluster secuenciales, aglomerativas, jerárquicas y anidadas. De acuerdo a la información recopilada de las frecuencias de los 25 alelos estudiados en trece poblaciones de aborígenes del NOA y Paraguay, las distancias genéticas obtenidas reflejan los caracteres lingüístico-culturales.

  6. An Antarctic hypotrichous ciliate, Parasterkiella thompsoni (Foissner) nov. gen., nov. comb., recorded in Argentinean peat-bogs: morphology, morphogenesis, and molecular phylogeny.

    Science.gov (United States)

    Küppers, Gabriela Cristina; Paiva, Thiago da Silva; Borges, Bárbara do Nascimento; Harada, Maria Lúcia; Garraza, Gabriela González; Mataloni, Gabriela

    2011-05-01

    The ciliate Parasterkiella thompsoni (Foissner, 1996) nov. gen., nov. comb. was originally described from Antarctica. In the present study, we report the morphology, morphogenesis during cell division, and molecular phylogeny inferred from the 18S-rDNA sequence of a population isolated from the Rancho Hambre peat bog, Tierra del Fuego Province (Argentina). The study is based on live and protargol-impregnated specimens. Molecular phylogeny was inferred from trees constructed by means of the maximum parsimony, neighbor joining, and Bayesian analyses. The interphase morphology matches the original description of the species. During the cell division, stomatogenesis begins with the de novo proliferation of two fields of basal bodies, each one left of the postoral ventral cirri and of transverse cirri, which later unify. Primordia IV-VI of the proter develop from disaggregation of cirrus IV/3, while primordium IV of the opisthe develops from cirrus IV/2 and primordia V and VI from cirrus V/4. Dorsal morphogenesis occurs in the Urosomoida pattern-that is, the fragmentation of kinety 3 is lacking. Three macronuclear nodules are generated before cytokinesis. Phylogenetic analyses consistently placed P. thompsoni within the stylonychines. New data on the morphogenesis of the dorsal ciliature justifies the transference of Sterkiella thompsoni to a new genus Parasterkiella. Copyright © 2011 Elsevier GmbH. All rights reserved.

  7. La fiction de Madame de Genlis, espace d’interrogation

    Directory of Open Access Journals (Sweden)

    Isabelle Tremblay

    2013-09-01

    Full Text Available The novel constitutes an ideal genre in which to discuss a central question in the eighteenth century: virtue. As opposed to her contemporaries, Mme de Genlis depicts virtue as a state of mind attained through independence and self-confidence rather than through the atonement of one’s faults. How do her heroines realize their potential? Are they able to find a middle ground between their perception of their roles and identity and the expectations that weigh on them? What paths are available to them?

  8. Sistema genérico de replicación

    OpenAIRE

    Jiménez Ortiz, Raúl

    2014-01-01

    Este proyecto se desarrolla en una de las principales compañías eléctricas de España, y trata sobre la creación de un sistema genérico de replicación de datos. La idea surge de la necesidad de estandarizar la forma de traspasar información entre departamentos o sistemas, debido a que existen gran variedad de interfaces diferentes, y cada vez que surge la necesidad de crear una implica nuevos costes de desarrollo, mantenimiento y futuros evolutivos. Entre los diferentes departamentos de ...

  9. TrayGen: Arranging objects for exhibition and packaging

    KAUST Repository

    Yang, Yongliang

    2013-10-01

    We present a framework, called TrayGen, to generate tray designs for the exhibition and packaging of a collection of objects. Based on principles from shape perception and visual merchandising, we abstract a number of design guidelines on how to organize the objects on the tray for the exhibition of their individual features and mutual relationships. Our framework realizes these guidelines by analyzing geometric shapes of the objects and optimizing their arrangement. We demonstrate that the resultant tray designs not only save space, but also highlight the characteristic of each object and the inter-relations between objects. © 2013 The Eurographics Association and John Wiley & Sons Ltd.

  10. Justicia en salud y genética

    OpenAIRE

    Maria Graciela De Ortuzar

    2014-01-01

    Las expectativas puestas en el conocimiento genético exceden el ámbito de la medicina tradiciona, debido a que la intervención directa en la lotería natural demandaría el replanteamiento de conceptos centrales de justicia en salud: necesidades médicas, enfermedad, normalidad, e igualdad de oportunidades en el acceso a la salud. El punto en debate es sí el replanteo de dichos conceptos conlleva un cambio radical en las teorías de justicia (libertariana y/o liberal), mostrando su obsolescencia,...

  11. 45 CFR 310.25 - What conditions apply to acquisitions of Computerized Tribal IV-D Systems?

    Science.gov (United States)

    2010-10-01

    ... FAMILIES, DEPARTMENT OF HEALTH AND HUMAN SERVICES COMPUTERIZED TRIBAL IV-D SYSTEMS AND OFFICE AUTOMATION Funding for Computerized Tribal IV-D Systems and Office Automation § 310.25 What conditions apply to... 45 Public Welfare 2 2010-10-01 2010-10-01 false What conditions apply to acquisitions of...

  12. Analysis of Phoenix Anomalies and IV and V Findings Applied to the GRAIL Mission

    Science.gov (United States)

    Larson, Steve

    2012-01-01

    Analysis of patterns in IV&V findings and their correlation with post-launch anomalies allowed GRAIL to make more efficient use of IV&V services . Fewer issues. . Higher fix rate. . Better communication. . Increased volume of potential issues vetted, at lower cost. . Hard to make predictions of post-launch performance based on IV&V findings . Phoenix made sound fix/use as-is decisions . Things that were fixed eliminated some problems, but hard to quantify. . Broad predictive success in one area, but inverse relationship in others.

  13. International VLBI Service for Geodesy and Astrometry: 1999 Annual Report

    Science.gov (United States)

    Vandenberg, Nancy R. (Editor)

    1999-01-01

    This volume of reports is the 1999 Annual Report of the International VLBI Service for Geodesy and Astrometry -IVS. The individual reports were contributed by VLBI groups in the international geodetic community who constitute the components of IVS. The 1999 Annual Report documents the work of the IVS components for the year ending March 1, 1999, the official inauguration date of IVS. As the newest of the space technique services, IVS decided to publish this Annual Report as a reference to our organization and its components. The entire contents of this Annual Report also appear on the IVS website at: http://ivscc.gsfc.nasa.gov/pub/arl999. The IVS 1999 Annual Report will be a valuable reference for information about IVS and its components. This Annual Report will serve as a baseline from which we can measure the anticipated progress of IVS in coming years.

  14. International VLBI Service for Geodesy and Astrometry

    Science.gov (United States)

    Vandenberg, Nancy R. (Editor); Baver, Karen D. (Editor)

    2001-01-01

    This volume of reports is the 2000 Annual Report of the International Very Long Base Interferometry (VLBI) Service for Geodesy and Astrometry (IVS). The individual reports were contributed by VLBI groups in the international geodetic and astrometric community who constitute the components of IVS. The 2000 Annual Report documents the work of these IVS components over the period March 1, 1999, through December 31, 2000. The reports document changes, activities, and progress of the IVS. The entire contents of this Annual Report also appear on the IVS web site at http://ivscc.gsfc.nasa.gov/publications/ar2000.

  15. Zirconium (IV) complexes with some polymethylenediimines | Na ...

    African Journals Online (AJOL)

    The syntheses of zirconium (IV) complexes have been carried out by the reaction of oxozirconium (IV) chloride with the appropriate diimines (Schiff bases). The complexes were isolated as yellow solids which are stable to heat. The complexes were found to be insoluble in most solvents. The infrared spectra, elemental ...

  16. Astragaloside IV liposomes ameliorates adriamycin-induced ...

    African Journals Online (AJOL)

    Methods: The rats were given a single tail intravenous injection of adriamycin (6 mg/kg) within 1 week, and then divided into four groups including normal, model, benazepril and astragaloside IV liposomes group. They were all orally administered dosage of benazepril and astragaloside IV liposomes once daily for 8 weeks.

  17. Generation IV reactors: international projects

    International Nuclear Information System (INIS)

    Carre, F.; Fiorini, G.L.; Kupitz, J.; Depisch, F.; Hittner, D.

    2003-01-01

    Generation IV international forum (GIF) was initiated in 2000 by DOE (American department of energy) in order to promote nuclear energy in a long term view (2030). GIF has selected 6 concepts of reactors: 1) VHTR (very high temperature reactor system, 2) GHR (gas-cooled fast reactor system), 3) SFR (sodium-cooled fast reactor system, 4) SCWR (super-critical water-cooled reactor system), 5) LFR (lead-cooled fast reactor system), and 6) MFR (molten-salt reactor system). All these 6 reactor systems have been selected on criteria based on: - a better contribution to sustainable development (through their aptitude to produce hydrogen or other clean fuels, or to have a high energy conversion ratio...) - economic profitability, - safety and reliability, and - proliferation resistance. The 6 concepts of reactors are examined in the first article, the second article presents an overview of the results of the international project on innovative nuclear reactors and fuel cycles (INPRO) within IAEA. The project finished its first phase, called phase-IA. It has produced an outlook into the future role of nuclear energy and defined the need for innovation. The third article is dedicated to 2 international cooperations: MICANET and HTR-TN. The purpose of MICANET is to propose to the European Commission a research and development strategy in order to develop the assets of nuclear energy for the future. Future reactors are expected to be more multiple-purposes, more adaptable, safer than today, all these developments require funded and coordinated research programs. The aim of HTR-TN cooperation is to promote high temperature reactor systems, to develop them in a long term perspective and to define their limits in terms of burn-up and operating temperature. (A.C.)

  18. Thermodynamic data for predicting concentrations of Th(IV), U(IV), Np(IV), and Pu(IV) in geologic environments

    Energy Technology Data Exchange (ETDEWEB)

    Rai, Dhanpat; Roa, Linfeng; Weger, H.T.; Felmy, A.R. [Battelle, Pacific Northwest National Laboratory (PNNL) (United States); Choppin, G.R. [Florida State University (United States); Yui, Mikazu [Waste Isolation Research Division, Tokai Works, Japan Nuclear Cycle Development Inst., Tokai, Ibaraki (Japan)

    1999-01-01

    This report provides thermodynamic data for predicting concentrations of Th(IV), U(IV), Np(IV), and Pu(IV) in geologic environments, and contributes to an integration of the JNC chemical thermodynamic database, JNC-TDB (previously PNC-TDB), for the performance analysis of geological isolation system for high-level radioactive wastes. Thermodynamic data for the formation of complexes or compounds with hydroxide, chloride, fluoride, carbonate, nitrate, sulfate and phosphate are discussed in this report. Where data for specific actinide(IV) species was lacking, the data were selected based on chemical analogy to other tetravalent actinides. In this study, the Pitzer ion-interaction model is used to extrapolate thermodynamic constants to zero ionic strength at 25degC. (author)

  19. Basis for the safety approach for design and assessment of Generation IV nuclear systems

    International Nuclear Information System (INIS)

    Fiorini, G.L.; Leahy, T.

    2009-01-01

    The primary objective of the RSWG is the implementation of a harmonized approach on long-term safety, and to address risk and regulatory issues in development of the next generation of nuclear systems. To this end, the group is proposing safety goals and evaluation methodology applicable for the design and assessment of future systems. The paper resumes the content of the first RSWG report which provides insights for the safety approach and assists the GIF Systems Steering Committee as well as the GIF Experts Group and the GIF Policy Group for the definition of the most adequate safety related Gen IV R and D. The document is also an essential contributor to help identifying the needed supportive crosscut R and D effort (i.e. applicable to all the innovative nuclear technologies). Although the report presents a number of thoughts and recommendations, it really represents only the start of the efforts for the RSWG. (author)

  20. Advanced Corrosion-Resistant Zr Alloys for High Burnup and Generation IV Application

    International Nuclear Information System (INIS)

    Jeong, Y. H.; Park, S. Y.; Lee, M. H.; Choi, B. K.; Baek, J. H.; Park, J. Y.; Kim, J. H.; Kim, H. G.; Jung, Y. H.; Bang, B. G.

    2006-08-01

    The systematic study was performed to develop the advanced corrosion-resistant Zr alloys for high burnup and Gen IV application. The corrosion behavior was significantly changed with the alloy composition and the corrosion environment. In general, the model alloys with a higher alloying elements showed a higher corrosion resistance. Among the model alloys tested in this study, Zr-10Cr-0.2Fe showed the best corrosion resistance regardless of the corrosion condition. The oxide on the higher corrosion-resistant alloy such as Zr-1.0Cr-0.2Fe consisted of mainly columnar grains, and it have a higher tetragonal phase stability. In comparison with other alloys being considered for the SCWR, the Zr alloys showed a lower corrosion rate than ferritic-martensitic steels. The results of this study imply that, at least from a corrosion standpoint, Zr alloys deserve consideration as potential cladding or structural materials in supercritical water cooled reactors

  1. Enfermedades genéticas del ADN mitocondrial humano

    Directory of Open Access Journals (Sweden)

    Solano Abelardo

    2001-01-01

    Full Text Available Las enfermedades mitocondriales son un grupo de trastornos que están producidos por un fallo en el sistema de fosforilación oxidativa (sistema Oxphos, la ruta final del metabolismo energético mitocondrial, con la consiguiente deficiencia en la biosíntesis del trifosfato de adenosina (ATP, por sus siglas en inglés. Parte de los polipéptidos que componen este sistema están codificados en el ácido desoxirribonucleico (DNA mitocondrial y, en los últimos años, se han descrito mutaciones que se han asociado con síndromes clínicos bien definidos. Las características genéticas del DNA mitocondrial, herencia materna, poliplasmia y segregación mitótica, confieren a estas enfermedades propiedades muy particulares. Las manifestaciones clínicas de estas enfermedades son muy heterogéneas y afectan a distintos órganos y tejidos por lo que su correcto diagnóstico implica la obtención de datos clínicos, morfológicos, bioquímicos y genéticos. El texto completo en inglés de este artículo está disponible en: http://www.insp.mx/salud/index.html

  2. PowerGen plc report and accounts 1995

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-12-31

    Detailed financial results are presented for the United Kingdom power generation company PowerGen for the year ended 2 April 1995. A review is given of operating and financial performance. Significant reductions in operating costs and improvements in productivity have been achieved. Diversity of fuels and plant portfolio has been enhanced by building 3000 MW of gas fired CCGT plant. Investment in coal import facilities has increased access to international coal markets. Environmental performance has improved with further reductions in SO{sub 2}, NO{sub x} and CO{sub 2} emissions. Overseas projects include construction of 990 MW CCGT power station in Portugal and a contract to build the 1200 MW Paiton 2 coal-fired power station in Indonesia. Investment in lignite mining and power generation assets of MIBRAG in Germany is contributing to profits. PowerGen`s five year contract for coal supply was assigned to RJB Mining (UK) Ltd. during the year. Stocks of coal fell during the year and further reductions are expected during 1995/96.

  3. Divergence and genetic variability among superior rubber tree genotypes Divergência e variabilidade genética de genótipos superiores de seringueira

    Directory of Open Access Journals (Sweden)

    Lígia Regina Lima Gouvêa

    2010-02-01

    Full Text Available The objective of this work was to estimate the genetic variability and divergence among 22 superior rubber tree (Hevea sp. genotypes of the IAC 400 series. Univariate and multivariate analyses were performed using eight quantitative traits (descriptors, including yield. In the univariate analyses, the estimated parameters were: genetic and environmental variances; genetic and environmental coefficients of variation; and the variation index. The Mahalanobis generalized distance, the Tocher agglomerative method and canonical variables were used for the multivariate analyses. In the univariate analyses, variability was verified among the genotypes for all the variables evaluated. The Tocher method grouped the genotypes into 11 clusters of dissimilarity. The first four canonical variables explained 87.93% of the cumulative variation. The highest genetic variability was found in rubber yield-related traits, which contributed the most to the genetic divergence. The most divergent pairs of genotypes are suggested for crossbreeding. The genotypes evaluated are suitable for breeding and may be used to continue the IAC rubber tree breeding program.O objetivo deste trabalho foi estimar a divergência e a variabilidade genética entre 22 genótipos superiores de seringueira (Hevea sp. da série IAC 400. Análises univariadas e multivariadas foram realizadas com oito caracteres quantitativos (descritores, incluindo produtividade. Na análise univariada, os parâmetros estimados foram: variâncias genética e ambiental, coeficientes de variação genética e ambiental, e índice de variação. A distância generalizada de Mahalanobis, o método aglomerativo de Tocher e variáveis canônicas foram utilizados nas análises multivariadas. Nas análises univariadas, verificou-se variabilidade entre os genótipos para todas as variáveis avaliadas. O método de Tocher agrupou os genótipos em 11 grupos de dissimilaridade. As quatro primeiras variáveis can

  4. Annual report 1990 annex IV

    International Nuclear Information System (INIS)

    Smith, B.; Foskolos, K.

    1991-01-01

    The Nuclear Energy Research Department consists of three Laboratories: Reactor Physics and Systems Engineering (LRS), Thermal Hydraulics (LTH), and Materials and Nuclear Processes (LWV). There are additionally two Research Programmes: 'Waste Disposal' (PES) and LWR-Safety (PLS). The Department's activities focus on three main areas: safety and safety-related operational problems of the Swiss nuclear power plants (NPPs), contributions to the issues involved in radioactive waste disposal, future reactors. In addition, scientific-technical services are provided in the nuclear and non-nuclear sectors and for the operation of the relevant site facilities. (author) figs., tabs., refs

  5. Importância da análise cromossômica dos fibroblastos em casos suspeitos de mosaicismo: experiência de um serviço de Genética Clínica Importancia del análisis cromosómico de los fibroblastos en casos sospechosos de mosaicismo: experiencia de un servicio de Genética Clínica Importance of the fibroblast chromosomal analysis in suspected cases of mosaicism: experience of a clinical Genetics service

    Directory of Open Access Journals (Sweden)

    Giorgio Adriano Paskulin

    2011-03-01

    Full Text Available OBJETIVOS: Verificar características clínicas e achados citogenéticos de pacientes com suspeita de mosaicismo submetidos à avaliação cromossômica por meio do cariótipo por bandas GTG de linfócitos e fibroblastos. MÉTODOS: Realizou-se uma análise retrospectiva dos pacientes avaliados no Serviço de Genética Clínica do Complexo Hospitalar Santa Casa de Porto Alegre da Universidade Federal de Ciências da Saúde de Porto Alegre, entre 1975 e 2009, por meio da coleta de dados clínicos e resultados da avaliação citogenética. RESULTADOS: A amostra foi composta de 15 pacientes, seis (40% do sexo masculino, e idades variando de dez dias a 14 anos. Na análise cromossômica do sangue, alterações foram observadas em quatro pacientes (26,7%, incluindo-se um caso de translocação balanceada [t(2;9pat] e três de mosaicismo [um caso, respectivamente, de mos 45,X/46,X,+mar; mos 46,XY,r(12/45,XY,-12/47,XY,r(12,+r(12 e mos 46,XY/47,XY,+9]. Com o objetivo de confirmar ou mesmo identificar um mosaicismo cromossômico, os pacientes foram submetidos posteriormente ao cariótipo de pele. Os principais motivos pelos quais os pacientes com cariótipo do sangue sem mosaicismo apresentaram tal suspeita foram a presença de hemi-hipertrofia (n=5 e de manchas hipocrômicas seguindo as linhas de Blaschko (n=4. Mosaicismo foi confirmado em dois casos e identificado em outros dois (dois casos de mos 46,XX/47,XX,+22. O mos 46,XY/47,XY,+9 não foi verificado no estudo dos fibroblastos. CONCLUSÕES: Os resultados ilustram a variabilidade tecidual característica dos casos de mosaicismo cromossômico, bem como confirmam a importância da avaliação de um segundo tecido para a determinação diagnóstica. Achados clínicos, como assimetria de membros e anomalias pigmentares seguindo as linhas de Blaschko, são fortemente indicativos da presença de mosaicismo.OBJETIVOS: Verificar características clínicas y hallazgos citogenéticos de pacientes con sospecha

  6. Gridded precipitation dataset for the Rhine basin made with the genRE interpolation method

    NARCIS (Netherlands)

    Osnabrugge, van B.; Uijlenhoet, R.

    2017-01-01

    A high resolution (1.2x1.2km) gridded precipitation dataset with hourly time step that covers the whole Rhine basin for the period 1997-2015. Made from gauge data with the genRE interpolation scheme. See "genRE: A method to extend gridded precipitation climatology datasets in near real-time for

  7. A 48-plex autosomal SNP GenPlex™ assay for human individualization and relationship testing

    DEFF Research Database (Denmark)

    Tomas Mas, Carmen; Børsting, Claus; Morling, Niels

    2012-01-01

    SNPs are being increasingly used by forensic laboratories. Different platforms have been developed for SNP typing. We describe the GenPlex™ HID system protocol, a new SNP-typing platform developed by Applied Biosystems where 48 of the 52 SNPforID SNPs and amelogenin are included. The GenPlex™ HID...

  8. ANALISIS SEKUEN GEN GLUTATION PEROKSIDASE (GPX1 SEBAGAI DETEKSI STRES OKSIDATIF AKIBAT INFEKSI MYCOBACTERIUM TUBERCULOSIS

    Directory of Open Access Journals (Sweden)

    Ari Yuniastuti

    2013-02-01

    Full Text Available Glutation merupakan antioksidan yang berperan dalam fungsi imun, dan diekspresikan secara genetik oleh urutan gen yang membentuk protein enzim Glutation Peroxidase (GPx1. Bila ekspresi gen berubah maka terjadi perubahan fungsi glutation dan kerentanan terhadap stress oksidatif. Metode yang digunakan adalah Kasus-kontrol. Sampel yang digunakan adalah sampel darah. Kelompok kasus adalah sampel darah pasien tuberkulosis paru sedangkan kelompok kontrol adalah sampel darah orang sehat. Pemeriksaan gen Glutation peroxidase (GPx1 menggunakan metode Polymerase Chain Reaction (PCR untuk melihat pita DNA pada pasien tuberkulosis par serta elektroforesis produk PCR-RFLP gen GPx1 kelompok sampel tuberkulosis. Hasil penelitian menunjukkan bahwa tidak terdapat hubungan yang bermakna antara polimorfisme gen GPx1 (p=0,365 pasein tuberkulois dengan individu sehat, sehingga tidak dapat digunakan sebagai alat deteksi kerentanan terhadap stress oksidatif pada pasien tuberkulosis. Perlu penelitian lanjutan yang menggunakan sampel lebih besar dan populasi etnik yang berbeda.

  9. Sistema inmune y genética: un abordaje diferente a la diversidad de anticuerpos.

    OpenAIRE

    Matta Camacho, Nubia Estela

    2011-01-01

    RESUMEN Es común encontrar en los libros de inmunología o de genética un capítulo con el título de “sistema inmune y genética”, sin embargo su asociación se centra en cómo la generación de anticuerpos rompió el paradigma “un gen, una proteína”, pues en el caso de la producción de anticuerpos, un gen produce millones de proteínas. El sistema inmune tiene muchos vínculos con la genética y la herencia; esta asociación se da porque cualquier sustancia o compuesto que produzca un organi...

  10. Eustochomorpha Girault, Neotriadomerus gen. n., and Proarescon gen. n. (Hymenoptera, Mymaridae, early extant lineages in evolution of the family

    Directory of Open Access Journals (Sweden)

    John T. Huber

    2017-06-01

    Full Text Available Eustochomorpha Girault, with one described species, E. haeckeli Girault, from Australia is redescribed. Neotriadomerus Huber, gen. n., is described, together with seven new species, all from Australia: N. burwelli Huber, sp. n., N. crassus Huber, sp. n., N. darlingi Huber, sp. n., N. gloriosus Huber, sp. n., N. longiovipositor Huber, sp. n., N. longissimus Huber, sp. n. (one of the largest species of Mymaridae, and N. powerae Huber, sp. n. Proarescon Huber, gen. n., is described for P. primitivum (Huber, comb. n., transferred from Borneomymar Huber, and P. similis Huber, sp. n., from Thailand. The previously unknown male of Borneomymar madagascar Huber is described and the genus is redescribed from critical point dried and slide mounted specimens. Triadomerini, stat. n., is proposed to include six genera: Borneomymar, Eustochomorpha and Neotriadomerus, and the Cretaceous Carpenteriana Yoshimoto, Macalpinia Yoshimoto and Triadomerus Yoshimoto. Aresconini is proposed to include five (possibly six genera: Arescon Enock, Kikiki Huber and Beardsley, Proarescon Huber and Tinkerbella Huber and Noyes, and the Cretaceous Myanmymar Huber and, tentatively, also Enneagmus Yoshimoto. The two tribes are proposed as being the earliest lineages in Mymaridae, with Neotriadomerus and Triadomerus being sister genera to the remaining extant and extinct genera, respectively.

  11. Adduct formation in Ce(IV) thenolytrifluoroacetonate

    International Nuclear Information System (INIS)

    Anufrieva, S.I.; Polyakova, G.V.; Snezhko, N.I.; Pechurova, N.I.; Martynenko, L.I.; Spitsyn, V.I.

    1982-01-01

    The literature contains no information on adduct formation in Ce(IV) β-diketonates with additional ligands. Since tetrakis-β-diketonates of Ce(IV) have four six-membered chelate rings, we can suppose that the introduction of an additional monodentate or bidentate ligand into the coordination sphere of Ce(IV) β-diketonates would lead to an increase in the coordination number (CN) of the Ce(IV) to nine or ten. The possibility of realization of such a high CN for Ce(IV) has not been proved; a study of adduct formation by Ce(IV) tetrakis-β-diketonates is thus of theoretical interest. Such an investigation might also be of practical interest, because the introduction of an additional ligand into the coordination sphere of a rare-earth β-diketonate usually increases the solubility of the β-diketonate in nonpolar solvents and increases the volatility of the compound; such a modification of the properties is important for various practical purposes. The aim of our work was to study the possibility of separating solid adducts of Ce(IV) tetrakis-thenoyltrifluoroacetonate with certain oxygen-containing and nitrogen-containing donor monodentate and bidentate ligands, and also to investigate their properties. As the β-diketone we used thenoyltrifluoroacetone (HTTFA), since in a parallel investigation it was found that Ce(TTFA) 4 has a high oxidation-reduction stability

  12. Potencial de vida útil pós-colheita de quatro genótipos de melão tipo Galia Potential of postharvest shelf life of four genotypes of Galia type melons

    Directory of Open Access Journals (Sweden)

    Patrícia Lígia Dantas de Morais

    2004-12-01

    Full Text Available Avaliou-se o potencial de vida útil pós-colheita de melões (Cucumis melo L. tipo Galia (genótipos Primal, Solarking, Total e Vicar. Utilizou-se o delineamento inteiramente casualizado em esquema fatorial 4 (genótipos x 4 (tempos de armazenamento: 0, 3, 6 e 9 dias, com três repetições. Os frutos foram colhidos no estádio de maturação IV (predominantemente amarelo e armazenados à temperatura de 20 ± 1ºC e umidade relativa de 50 ± 2%. O genótipo Solarking apresentou uma firmeza média de polpa superior aos demais, do inicio ao final do período de armazenamento. Em todos os genótipos, os valores de sólidos solúveis no início do armazenamento encontraram-se dentro da faixa aceitável para comercialização no mercado externo, havendo pouca variação com o decorrer do período de armazenamento. A aparência interna limitou o tempo de vida útil pós-colheita do genótipo Total em apenas seis dias. Os genótipos Solarking, Vicar e Primal apresentaram maior potencial na conservação pós-colheita, principalmente o híbrido Solarking, que chegou aos nove dias de armazenamento com boa aparência interna.The postharvest life span of Galia (genotypes Primal, Solarking, Total, and Vicar melons (Cucumis melo L. was evaluated by a four (genotypes x four (storage periods: 0, 3, 6, and 9 days factorial experiment, in a completely randomized design with three replications. The fruits were harvested at maturation stage IV (yellow color predominance, and stored under 20 ± 1ºC and HR 50 ± 2%. Solarking's average firmness was better than that of the other genotypes during the experimental period. At the beginning of the experiment all genotypes had soluble solids contents at the level (eight to ten percent required for exportation, with these levels varying slightly during storage. The internal aspect limited to six days the postharvest life span of genotype Total. Solarking, Vicar, and Primal showed great postharvest conservation potential

  13. Market opportunities: U.S. - PADD IV

    International Nuclear Information System (INIS)

    Garner, R.P.

    1997-01-01

    The current supply and demand balance, the short and long term expectations and marketing opportunities for Canadian crude oil in PADD IV, the Rocky Mountain region in the US, were reviewed. It was suggested that market opportunities in PADD IV are derived from the following four factors: (1) crude oil declines within that area, (2) federal regulations, (3) competitive presence with markets, and (4) population growth. The overall conclusion was that Canadian producers and PADD IV refiners will be looking at an ever-growing relationship based on freight equalized world crude prices. 8 tabs., 5 figs

  14. Type IV Wind Turbine Model

    DEFF Research Database (Denmark)

    Hansen, Anca Daniela; Margaris, Ioannis D.

    . In the project, this wind turbine model will be further incorporated in a wind power plant model together with the implementation in the wind power control level of the new control functionalities (inertial response, synchronising power and power system damping). For this purpose an aggregate wind power plant......This document is created as part of the EaseWind project. The goal of this project is to develop and investigate new control features for primary response provided by wind power plants. New control features as inertial response, synchronising power and power system damping are of interest to EaseWind...... project to be incorporated in the wind power plant level. This document describes the Type 4 wind turbine simulation model, implemented in the EaseWind project. The implemented wind turbine model is one of the initial necessary steps toward integrating new control services in the wind power plant level...

  15. Aconselhamento genético do paciente com doença falciforme Genetic counseling in the sickle cell disease

    Directory of Open Access Journals (Sweden)

    Antonio Sérgio Ramalho

    2007-09-01

    Full Text Available O aconselhamento genético é um componente importante da conduta médica na doença falciforme, apresentando relevantes implicações médicas, psicológicas, sociais, éticas e jurídicas. No presente trabalho são apresentadas as considerações sobre esse processo, elaboradas pelo Serviço de Aconselhamento Genético em Hemoglobinopatias da Unicamp, mediante solicitação do Programa Nacional de Atenção Integral às Pessoas com Doença Falciforme e outras Hemoglobinopatias do Ministério da Saúde.Genetic counseling is a major component of medical conduct in sickle cell disease with relevant medical, psychological, social, ethical and judicial implications. In the current work considerations of this process elaborated by the Genetic Counseling Service on Hemoglobinopathies of Unicamp at the request of the National Program of Comprehensive Care to Sufferers of Sickle Cell Disease and other Hemoglobinopathies, of the Brazilian Ministry of Health, are presentedl.

  16. Diorganotin(IV) Complexes with Methionine Methyl Ester. Equilibria ...

    African Journals Online (AJOL)

    IV) (DBT) and diphenyltin(IV) (DPT) was investigated at 25 °C and 0.1 mol dm–3 ionic strength in water for dimethyltin(IV) and in 50 % dioxane–water mixture for dibutyltin(IV) and diphenyltin(IV). Methionine methyl ester forms1:1 and 1:2 ...

  17. Periodontal Disease Part IV: Periodontal Infections

    OpenAIRE

    Turnbull, Robert S.

    1988-01-01

    In Part IV of this article, the author describes two periodontal infections, acute necrotizing ulcerative gingivitis (trench mouth) and periodontal abscess, both acute painful conditions for which patients may seek advice from their family physician rather than their dentist.

  18. Safety assessment for Generation IV nuclear systems

    International Nuclear Information System (INIS)

    Leahy, T.J.

    2012-01-01

    The Generation IV International Forum (GIF) Risk and Safety Working Group (RSWG) was created to develop an effective approach for the safety of Generation IV advanced nuclear energy systems. Recent RSWG work has focused on the definition of an integrated safety assessment methodology (ISAM) for evaluating the safety of Generation IV systems. ISAM is an integrated 'tool-kit' consisting of 5 analytical techniques that are available and matched to appropriate stages of Generation IV system concept development: 1) qualitative safety features review - QSR, 2) phenomena identification and ranking table - PIRT, 3) objective provision tree - OPT, 4) deterministic and phenomenological analyses - DPA, and 5) probabilistic safety analysis - PSA. The integrated methodology is intended to yield safety-related insights that help actively drive the evolving design throughout the technology development cycle, potentially resulting in enhanced safety, reduced costs, and shortened development time

  19. Determination of uranium (IV) by flow voltammetry

    International Nuclear Information System (INIS)

    Ding Anqing

    1987-01-01

    According to the quantitative reaction of U(IV) and Fe(III) in H 2 SO 4 as well as the relation between current and concentration of substance detected, U(IV) has been determined indirectly by measurement of the electrolysis current of residual Fe(III). The columniform electrode used is made of glass carbon particles. At the range of U(IV) from a few micrograms to 40 μg, the linear relation is excellent. The relative standard deviation is within ±4%. The interference of Fe(II), Ti(IV) and U(VI) is negligible but of Ti(III) is serious. This method has been successfully applied in the determination of actual samples (both out line and on line). Main advantages of this procedure are rapid, simple, small amount of sample (only at microgram level) and easy to realize automation, able to use for on line or process analysis

  20. IV&V Project Assessment Process Validation

    Science.gov (United States)

    Driskell, Stephen

    2012-01-01

    The Space Launch System (SLS) will launch NASA's Multi-Purpose Crew Vehicle (MPCV). This launch vehicle will provide American launch capability for human exploration and travelling beyond Earth orbit. SLS is designed to be flexible for crew or cargo missions. The first test flight is scheduled for December 2017. The SLS SRR/SDR provided insight into the project development life cycle. NASA IV&V ran the standard Risk Based Assessment and Portfolio Based Risk Assessment to identify analysis tasking for the SLS program. This presentation examines the SLS System Requirements Review/System Definition Review (SRR/SDR), IV&V findings for IV&V process validation correlation to/from the selected IV&V tasking and capabilities. It also provides a reusable IEEE 1012 scorecard for programmatic completeness across the software development life cycle.

  1. Genetics Home Reference: mucopolysaccharidosis type IV

    Science.gov (United States)

    ... enzymes, GAGs accumulate within cells, specifically inside the lysosomes . Lysosomes are compartments in the cell that break down ... that cause molecules to build up inside the lysosomes are called lysosomal storage disorders. In MPS IV, ...

  2. International Conference on NextGen Electronic Technologies

    CERN Document Server

    Thalmann, Nadia; Bhaaskaran, V

    2017-01-01

    This book is a collection of keynote lectures from international experts presented at International Conference on NextGen Electronic Technologies (ICNETS2-2016). ICNETS2 encompasses six symposia covering all aspects of electronics and communications domains, including relevant nano/micro materials and devices . This volume comprises of recent research in areas like computational signal processing analysis, intelligent embedded systems, nanoelectronic materials and devices, optical and microwave technologies, VLSI design: circuits systems and application, and wireless communication networks, and the internet of things. The contents of this book will be useful to researchers, professionals, and students working in the core areas of electronics and their applications, especially to signal processing, embedded systems, and networking.

  3. Els orígens de la tuberculosi

    OpenAIRE

    Bueno i Torrens, David, 1965-

    2014-01-01

    La tuberculosi és una de les primeres malalties infeccioses de la història de la humanitat. Es dedueix del registre fòssil, per les empremtes que deixa en els ossos d"algunes de les persones que l"han patit. Tradicionalment s"ha assumit que la tuberculosi ve del bestiar boví, que la va transmetre per primer cop a les persones durant el neolític. Però l"anàlisi genètica dels bacteris causants d"aquesta malaltia en diversos indrets del món i de bacteris fòssils trobats en mòmies precolombines h...

  4. Commissioning and Performance Analysis of WhisperGen Stirling Engine

    Science.gov (United States)

    Pradip, Prashant Kaliram

    Stirling engine based cogeneration systems have potential to reduce energy consumption and greenhouse gas emission, due to their high cogeneration efficiency and emission control due to steady external combustion. To date, most studies on this unit have focused on performance based on both experimentation and computer models, and lack experimental data for diversified operating ranges. This thesis starts with the commissioning of a WhisperGen Stirling engine with components and instrumentation to evaluate power and thermal performance of the system. Next, a parametric study on primary engine variables, including air, diesel, and coolant flowrate and temperature were carried out to further understand their effect on engine power and efficiency. Then, this trend was validated with the thermodynamic model developed for the energy analysis of a Stirling cycle. Finally, the energy balance of the Stirling engine was compared without and with heat recovery from the engine block and the combustion chamber exhaust.

  5. Festival du rire de Genève

    CERN Document Server

    Staff Association

    2015-01-01

    Connaissez-vous le Festival du rire de Genève ? La deuxième édition aura lieu du 25 au 28 mars 2015 au Casino-Théâtre à Carouge. Côté programmation, Marc Donnet-Monay ouvre les festivités avant trois autres soirées de folie et d’humour que nous vous laissons le soin de découvrir dans le programme : http://www.rire-geneve.ch/#programme. Réduction de 30% sur l’achat de places pour les membres du personnel du CERN. Pour cela, il suffit de se rendre sur la billetterie en ligne de notre site : www.rire-geneve.ch et d’utiliser le code promotionnel. Contacter le secrétariat de l’Association du personnel (Staff.Association@cern.ch) pour connaitre ce code promotionnel.

  6. How Gen Y and Boomers will reshape your agenda.

    Science.gov (United States)

    Hewlett, Sylvia Ann; Sherbin, Laura; Sumberg, Karen

    2009-01-01

    When it comes to workplace preferences, Generation Y workers closely resemble Baby Boomers. Because these two huge cohorts now coexist in the workforce, their shared values will hold sway in the companies that hire them. The authors, from the Center for Work-Life Policy, conducted two large-scale surveys that reveal those values. Gen Ys and Boomers are eager to contribute to positive social change, and they seek out workplaces where they can do that. They expect flexibility and the option to work remotely, but they also want to connect deeply with colleagues. They believe in employer loyalty but desire to embark on learning odysseys. Innovative firms are responding by crafting reward packages that benefit both generations of workers--and their employers.

  7. The sale of National Power and PowerGen

    International Nuclear Information System (INIS)

    1992-06-01

    In March 1991, the Secretary of State for Energy sold approximately 60 per cent of the shares in National Power and PowerGen who generate most of the electricity produced in England and Wales. The Government's overriding objective was to complete the privatisation of the electricity industry during the lifetime of the Parliament. Within that overriding objective, the Department sought: to maximise net proceeds; to deepen share ownership among individuals; to achieve the overall recognition that the sale of the two companies had been a success; and to achieve a modest premium on the issue price following the state of share dealings. This report sets out the results of a National Audit Office examination of how far the Department achieved their objectives for the sale, and how they controlled its costs. (author)

  8. Genética de las epilepsias Genetics of epilepsy

    Directory of Open Access Journals (Sweden)

    Gustavo A. Charria-Ortiz

    2007-01-01

    Full Text Available En años recientes se ha podido definir con gran exactitud la existencia de alteraciones genéticas específicas en una gran variedad de síndromes epilépticos tradicionales. Es decir, por vez primera se ha podido relacionar de manera contundente y predecible la presencia de alteraciones genómicas y/o proteómicas con síndromes epilépticos antes considerados como "idiopáticos". La gran mayoría de dichos defectos han sido encontrados en genes codificadores para canales iónicos y/o receptores de membrana, lo cual en cierto modo confirma la ya antes postulada relevancia que estas estructuras tienen en la actividad electroquímica espontánea neuronal cuyo desajuste conllevaría a ciertas formas de epilepsia. Esta revisión se centra en los aspectos genéticos y clínicos de dichas condiciones y alteraciones. También se revisarán brevemente los estudios más relevantes de la literatura médica según los cuales -aun a pesar de no haberse definido con la misma exactitud el tipo de anomalías etiológicas- puede tranquilamente inferirse el gran componente genético que parece subyacer a la etiología de las epilepsias. Por ultimo se enfatizará en que a pesar de dichos descubrimientos, su aplicación en la práctica clínica diaria aun es muy limitada, no solo por la relativa rareza de algunos de tales síndromes neurológicos sino también por la poca relevancia que hasta ahora ellos han tenido en el manejo médico rutinario de la mayoría de los pacientes. Las posibilidades inmediatas de tales avances -incluida la farmacogenómica-, así como los posibles conflictos éticos en que se podría incurrir serán también brevemente discutidos.In the last few years, the presence of specific genetic abnormalities leading to some of the classical epileptic syndromes has been clearly elucidated. This means that for the first time, it has become possible to create a strong relationship between the presence of specific genomic and/or proteomic

  9. Big Bang à Genève - French version only

    CERN Multimedia

    2005-01-01

    C'est la dernière conférence du cycle organisé par la section de physique de l'Université de Genève à l'occasion de l'Année internationale de la physique. Pour le bouquet final, la section de physique a choisi le grand boum du Big Bang. Intitulée « Big Bang à Genève », la conférence donnée par Laurent Chevalier de l'institut français CEA Saclay évoquera les expériences qui se préparent au CERN avec le LHC. Leur but est de reproduire et d'analyser les conditions qui prévalaient à l'origine de l'Univers, juste après le Big Bang. L'exposé décrira de façon simple les techniques utilisées pour cette exploration, qui démarrera en 2007. Laurent Chevalier se demandera avec le public quels phénomènes nouveaux les physiciens espèrent découvrir dans ce monde inexploré. Comme les précédentes, la conférence débutera par une démonstration de détection de rayons cosmiques dans l'auditoire et l'utilisation de ces signaux pour créer une « musique cosmique », en collaboration avec le Pr...

  10. Dsm-iv hypochondriasis in primary care

    OpenAIRE

    Escobar, JI; Gara, M; Waitzkin, H; Silver, RC; Holman, A; Compton, W

    1998-01-01

    The object of this study was to assess the prevalence and correlates of the DSM-IV diagnosis of hypochondriasis in a primary care setting. A large sample (N = 1456) of primary care users was given a structured interview to make diagnoses of mood, anxiety, and somatoform disorders and estimate levels of disability. The prevalence of hypochondriasis (DSM-IV) was about 3%. Patients with this disorder had higher levels of medically unexplained symptoms (abridged somatization) and were more impair...

  11. COBRA-IV wire wrap data comparisons

    International Nuclear Information System (INIS)

    Donovan, T.E.; George, T.L.; Wheeler, C.L.

    1979-02-01

    Thermal hydraulic analyses of hexagonally packed wire-wrapped fuel assemblies are complicated by the induced crossflow between adjacent subchannels. The COBRA-IV computer code simultaneously solves the hydrodynamics and thermodynamics of fuel assemblies. The modifications and the results are presented which are predicted by the COBRA-IV calculation. Comparisons are made with data measured in five experimental models of a wire-wrapped fuel assembly

  12. Quantificação da divergência genética entre acessos de goibeira por meio da estratégia Ward-MLM

    Directory of Open Access Journals (Sweden)

    Bianca Machado Campos

    2013-06-01

    Full Text Available O presente trabalho teve como objetivo quantificar a divergência genética entre 138 acessos de goiabeira procedentes do banco de germoplasma da Universidade Estadual do Norte Fluminense Darcy Ribeiro (UENF, com base em descritores morfológicos, agronômicos e físico-químicos, por meio do procedimento Ward - Modified Location Model (MLM. Para tanto, foram avaliados 13 descritores, sendo cinco qualitativos (coloração da polpa, superfície do fruto, formato do fruto ao final do pedúnculo, largura do pescoço e uniformidade da cor da polpa e oito quantitativos (massa média do fruto, diâmetro longitudinal do fruto, diâmetro transversal do fruto, rendimento da polpa, teor de sólidos solúveis totais, acidez do fruto, relação teor de sólidos solúveis totais e acidez do fruto e teor de ácido ascórbico. Detectou-se ampla variabilidade genética pelos dados morfológicos, agronômicos e físico-químicos nos 138 acessos de goiaba. Pelo procedimento da função da verossimilhança, determinou-se oito o número ideal de grupos, com um valor de incremento de 67,51. O grupo III foi considerado o mais distante, enquanto os grupos I, II, IV, V e VI, os mais próximos. O procedimento Ward-MLM é uma ferramenta útil para detectar divergência genética e agrupar os acessos utilizando, simultaneamente, variáveis qualitativas e quantitativas.

  13. Frecuencia de algunas enfermedades genéticas en Neuropediatría Frequency of some genetic diseases in Neuropediatrics

    Directory of Open Access Journals (Sweden)

    Tatiana Zaldívar Vaillant

    2012-12-01

    Full Text Available Introducción: las enfermedades neurológicas en Pediatría son diversas y obedecen a un gran número de causas: infecciosas, genéticas, metabólicas y degenerativas, entre otras. El diagnóstico genético, dentro del método clínico en Neurología, está relacionado con el diagnóstico etiológico. Existen muy pocas publicaciones que reflejen la frecuencia de las enfermedades neurogenéticas como grupo etiológico. Objetivo: describir la frecuencia de algunas enfermedades neuropediátricas en la Consulta de Neurogenética del Instituto de Neurología y Neurocirugía. Métodos: se realizó una investigación descriptiva y prospectiva en el periodo 2008-2010. Se clasificó a los pacientes por grupos etarios, y se calculó el porcentaje de frecuencia para la atrofia muscular espinal de la infancia, la distrofia muscular tipo Duchenne/Becker, las lesiones estáticas del sistema nervioso central de causa prenatal genética, y para la clasificación de los grupos según tipo de herencia. Resultados: el universo de estudio estuvo conformado por 161 pacientes, 72,6 % del sexo masculino, para una razón de la variable sexo de 2,5. Los escolares fueron mayoría (37,8 %, y la edad promedio 5 años. La distrofia muscular tipo Duchenne fue la enfermedad más frecuente (24,8 %. El 41,40 % clasificó en la herencia autosómica recesiva. Los resultados coinciden con lo reportado en la literatura. Conclusiones: las enfermedades neuromusculares hereditarias, y las lesiones estáticas del sistema nervioso central de causa prenatal genética, son las más frecuentes de solicitud de asesoramiento genético en un servicio de Neurogenética.Introduction: diverse neurological diseases are present in pediatrics and respond to a great number of causes, that is, infectious, genetic, metabolic and degenerative, among others. Within the clinical method in neurology, the genetic diagnosis is related to the etiological diagnosis. There are very few publications that show

  14. Synthesis and characterization of chiral thorium(IV) and uranium(IV) benzamidinate complexes

    Energy Technology Data Exchange (ETDEWEB)

    Schoene, Sebastian; Maerz, Juliane; Kaden, Peter; Patzschke, Michael; Ikeda-Ohno, Atsushi [Helmholtz-Zentrum Dresden-Rossendorf e.V., Dresden (Germany). Chemistry of the F-Elements

    2017-06-01

    Two chiral benzamidinate complexes of tetravalent actinides (Th(IV) and U(IV)) were synthesized using a salt metathesis reaction of the corresponding actinide(IV) tetrachlorides and the potassium salt of the chiral benzamidine (S,S)-N,N-Bis-(1-phenylethyl)-benzamidine ((S)-HPEBA). The structure of the complexes was determined with single crystal X-ray diffraction. These are the first examples of chiral amidinate complexes of actinides.

  15. Description of Sharon gen. nov. for the Chilean species Asaphes amoenus Philippi, 1861 (Coleoptera: Elateridae

    Directory of Open Access Journals (Sweden)

    Elizabeth T. Arias-Bohart

    2015-10-01

    Full Text Available Sharon gen. nov. is here described to include Asaphes? amoenus Philippi, 1861 comb. nov. from Chile. A redescription of the species is based on the female holotype and material from different geographic locations. Candèze (1891 placed Asaphes amoenus and Parasaphes elegans in the suprageneric group Asaphites. We discuss differences between Sharon gen. nov. and Hemicrepidius Germar, 1839, where Asaphes amoenus was later placed by Blackwelder (1944. Based on morphological characters, Sharon gen. nov. appears to be related to Parasaphes Candèze, 1881, Wynarka Calder, 1986, and Tasmanelater Calder, 1996, all from Australia, suggesting Gondwanan relationships.

  16. Estudio de la variabilidad genética en camélidos bolivianos

    OpenAIRE

    Barreta Pinto, Julia

    2013-01-01

    El estudio de los camélidos sudamericanos es de gran interés en los países andinoscomo Perú, Bolivia, Chile, Argentina, debido a su importante valor económico y suimportancia en el mantenimiento y desarrollo de las poblaciones rurales en dichos países. Dada la falta de estudios genéticos centrados en las poblaciones de camélidos quehabitan en Bolivia, y la necesidad de realizar una valoración de la diversidad genética deestas poblaciones, la presente Tesis doctoral ha abordado el estudio gené...

  17. Consideraciones genéticas sobre las dislipidemias y la aterosclerosis

    OpenAIRE

    Julio César Fernández Travieso

    2008-01-01

    La interacción entre factores genéticos y ambientales explican muchos aspectos de la aterosclerosis y las variaciones genéticas constituyen marcadores de riesgo de la enfermedad coronaria (EC), la cual ocupa el primer lugar entre las causas de morbilidad y mortalidad a nivel mundial. La predisposición familiar a padecer EC, junto al avance vertiginoso en técnicas de análisis de ADN y la disponibilidad de secuencias del genoma humano, han orientado la investigación de alteraciones genéticas re...

  18. Conceptos básicos de programación genética

    Directory of Open Access Journals (Sweden)

    José Jesús Martínez Páez

    2001-04-01

    Full Text Available La Programación Genética, PG, es un retoño de los Algoritmos Genéticos, en la cual los cromosomas que sufren la adaptación son en sí mismos programas de computador. Se usan operadores genéticos  especializados que generalizan la recombinación sexual y la mutación, para los programas de computador estructurados en árbol que están bajo adaptación.

  19. Manipulación genética de seres humanos

    OpenAIRE

    Manuel Santos Alcántara

    2006-01-01

    El gran avance que ha tenido la Genética en los últimos años y, particularmente, aquello relacionado con el desciframiento del genoma humano, ha traído a la discusión pública la posibilidad concreta de manipular genéticamente a los seres humanos. El mejoramiento o perfeccionamiento genético de los seres humanos, denominado eugenesia, actualmente se ha convertido técnicamente en una realidad, motivando una profunda reflexión de tipo ético. La pregunta básica es la siguiente: aquello que es téc...

  20. Polimorfismos del gen ob en bovinos de raza holstein en la Comarca Lagunera, México

    OpenAIRE

    Sarai S. Mendoza-Retana; Miguel A. Gallegos-Robles; Uriel González-Salas; José L. García-Hernández; Manuel Fortis-Hernández; Cirilo Vázquez-Vázquez; Héctor I. Trejo-Escareño

    2017-01-01

    La Comarca Lagunera es la cuenca lechera más importante de México. En la actualidad se están utilizando diversas técnicas que permiten evaluar genéticamente el animal a una edad temprana, permitiendo seleccionar futuros reproductores con características deseables. Entre los genes relacionados con la producción de leche, se encuentran el gen Ob también llamado gen Leptina el cual actúa sobre el sistema nervioso central y tejidos periféricos jugando un papel muy importante ...

  1. Discusión: Explicaciones genéticas y psicológicas de la esquizofrenia.Genética de la esperanza

    Directory of Open Access Journals (Sweden)

    Silvio Bolaños-Salvatierra

    2003-01-01

    Full Text Available En este documento se rebaten críticas hechas por Raventós y Jensen al artículo “Genética y comportamiento”. Cuatro temas fueron seleccionados: 1 se determina que los antipsicóticos aparecieron veinte años después de la concepción hereditaria de la esquizofrenia; 2 se considera que la discusión es altamente pertinente, para nada bizantina o irrelevante, debido que persisten prácticas epistémicas riesgosas en los investigadores genético-conductuales; 3 aunque ninguna conducta humana está exenta de influencia constitucional, el enfoque biologicista se ha propasado al pretender explicar genéticamente casi todo, desconfirmando solapadamente la importancia de la historia personal; y, 4 se plantea que la investigación biológica sobrevalora el peso de las anomalías genéticas frente a la historia social, por lo que solo aparenta cautela. Se propone investigar genéticamente la esperanza con el objetivo de saturar a la humanidad con ese tipo de explicaciones, para alcanzar más rápido una convivencia basada en la tolerancia y el respeto.

  2. The 1st reveal of Gen-V nuclear energy. Prospecting investigation of nuclear power 2050 (A2050) for energy innovation in the nuclear industry

    International Nuclear Information System (INIS)

    Woo, Tae Ho; Lee, Soon Ho

    2012-01-01

    The proposed strategy for the future nuclear energy is analyzed. The conventional nuclear power plants (NPPs) are investigated by the 21 st style interdisciplinary research as the information technology (IT), nanotechnology (NT), and biological technology (BT). New kinds of energy production methods as spherical isotropic power reactor (SIPR) and nano lattice power (NLP) are introduced. In addition, the problems of Gen-IV technologies are challenged to be solved, which is the matters of the mechanical and thermal controls of several coolants cases. The simulation result shows the increasing for the usefulness of the business. The core and vessel are very tractable due to moving core vessel (SIPR). The concept of safety system is changed to be submerged into coolant instead of injection concept (SIPR). The commercial fusion energy is realized for mass energy productions (NLP). Eventually, the safety as well as economical status is increased comparing to previous NPPs. (orig.)

  3. The 1{sup st} reveal of Gen-V nuclear energy. Prospecting investigation of nuclear power 2050 (A2050) for energy innovation in the nuclear industry

    Energy Technology Data Exchange (ETDEWEB)

    Woo, Tae Ho [Seoul National Univ. (Korea, Republic of). Dept. of Nuclear Engineering; Lee, Seok Jong [POSCO Engineering and Construction Co., Ltd., Incheon (Korea, Republic of); Lee, Soon Ho [SK Engineering and Construction Co., Ltd., Seoul (Korea, Republic of)

    2012-11-15

    The proposed strategy for the future nuclear energy is analyzed. The conventional nuclear power plants (NPPs) are investigated by the 21{sup st} style interdisciplinary research as the information technology (IT), nanotechnology (NT), and biological technology (BT). New kinds of energy production methods as spherical isotropic power reactor (SIPR) and nano lattice power (NLP) are introduced. In addition, the problems of Gen-IV technologies are challenged to be solved, which is the matters of the mechanical and thermal controls of several coolants cases. The simulation result shows the increasing for the usefulness of the business. The core and vessel are very tractable due to moving core vessel (SIPR). The concept of safety system is changed to be submerged into coolant instead of injection concept (SIPR). The commercial fusion energy is realized for mass energy productions (NLP). Eventually, the safety as well as economical status is increased comparing to previous NPPs. (orig.)

  4. Solubility study of Tc(IV) oxides

    International Nuclear Information System (INIS)

    Liu, D.J.; Fan, X.H.

    2005-01-01

    The deep geological disposal of the high level radioactive wastes is expected to be a safer disposal method in most countries. The long-lived fission product 99 Tc is present in large quantities in nuclear wastes and its chemical behavior in aqueous solution is of considerable interest. Under oxidizing conditions technetium exists as the anionic species TcO 4 - whereas under the reducing conditions, expected to exist in a deep geological repository, it is generally predicted that technetium will be present as TcO 2 ·nH 2 O. Hence, the mobility of Tc(IV) in reducing groundwater may be limited by the solubility of TcO 2 ·nH 2 O under these conditions. Due to this fact it is important to investigate the solubility of TcO 2 ·nH 2 O. The solubility determines the release of radionuclides from waste form and is used as a source term in radionuclide migration analysis in performance assessment of radioactive waste repository. Technetium oxide was prepared by reduction of a technetate solution with Sn 2 + . The solubility of Tc(IV) oxide has been determined in simulated groundwater and redistilled water under aerobic and anaerobic conditions. The effects of pH and CO 3 2- concentration of solution on solubility of Tc(IV) oxide were studied. The concentration of total technetium and Tc(IV) species in the solutions were periodically determined by separating the oxidized and reduced technetium species using a solvent extraction procedure and counting the beta activity of the 99 Tc with a liquid scintillation counter. The experimental results show that the rate of oxidation of Tc(IV) in simulated groundwater and redistilled water is about (1.49-1.86) x 10 -9 mol/(L·d) under aerobic conditions, but Tc(IV) in simulated groundwater and redistilled water is not oxidized under anaerobic conditions. Under aerobic or anaerobic conditions the solubility of Tc(IV) oxide in simulated groundwater and redistilled water is equal on the whole after centrifugation or ultrafiltration. The

  5. Solubility of Tc(IV) oxides

    International Nuclear Information System (INIS)

    Liu, D.J.; Fan, X.H.

    2005-01-01

    Full text of publication follows: The deep geological disposal of the high level radioactive wastes is expected to be a safer disposal method in most countries. The long-lived fission product 99 Tc is present in large quantities in nuclear wastes and its chemical behavior in aqueous solution is of considerable interest. Under the reducing conditions, expected to exist in a deep geological repository, it is generally predicted that technetium will be present as TcO 2 .nH 2 O. The solubility of Tc(IV) is used as a source term in performance assessment of radioactive waste repository. Technetium oxide was prepared by reduction of a technetate solution with Sn 2+ . The solubility of Tc(IV) oxide has been determined in simulated groundwater and re-distilled water under aerobic and anaerobic conditions. The effects of pH and CO 3 2- concentration of solution on solubility of Tc(IV) oxide were studied. The concentration of total technetium and Tc(IV) species in the solutions were periodically determined by separating the oxidized and reduced technetium species using a solvent extraction procedure and counting the beta activity of the 99 Tc with a liquid scintillation counter. The experimental results show that the rate of oxidation of Tc(IV) in simulated groundwater and re-distilled water is about (1.49∼1.86) x 10 -9 mol/(L.d) under aerobic conditions, but Tc(IV) in simulated groundwater and re-distilled water is not oxidized under anaerobic conditions. Under aerobic or anaerobic conditions the solubility of Tc(IV) oxide in simulated groundwater and re-distilled water is equal on the whole after centrifugation or ultrafiltration. The solubility of Tc(IV) oxide decreases with the increase of pH at pH 10 and is pH independent in the range 2 -8 to 10 -9 mol/L at 2 3 2- concentration. These data could be used to estimate the Tc(IV) solubility for cases where solubility limits transport of technetium in reducing environments of high-level waste repositories. (authors)

  6. High cost of stage IV pressure ulcers.

    Science.gov (United States)

    Brem, Harold; Maggi, Jason; Nierman, David; Rolnitzky, Linda; Bell, David; Rennert, Robert; Golinko, Michael; Yan, Alan; Lyder, Courtney; Vladeck, Bruce

    2010-10-01

    The aim of this study was to calculate and analyze the cost of treatment for stage IV pressure ulcers. A retrospective chart analysis of patients with stage IV pressure ulcers was conducted. Hospital records and treatment outcomes of these patients were followed up for a maximum of 29 months and analyzed. Costs directly related to the treatment of pressure ulcers and their associated complications were calculated. Nineteen patients with stage IV pressure ulcers (11 hospital-acquired and 8 community-acquired) were identified and their charts were reviewed. The average hospital treatment cost associated with stage IV pressure ulcers and related complications was $129,248 for hospital-acquired ulcers during 1 admission, and $124,327 for community-acquired ulcers over an average of 4 admissions. The costs incurred from stage IV pressure ulcers are much greater than previously estimated. Halting the progression of early stage pressure ulcers has the potential to eradicate enormous pain and suffering, save thousands of lives, and reduce health care expenditures by millions of dollars. Copyright © 2010 Elsevier Inc. All rights reserved.

  7. Direct complexonometric determination of thorium (IV), uranium (IV), neptunium (IV), plutonium (IV) by titration of diethylenetriaminepentaacetic acid with xylenol orange as indicator

    International Nuclear Information System (INIS)

    Rykov, A.G.; Piskunov, E.M.; Timofeev, G.A.

    1975-01-01

    The purpose of the present work was to develop a method of determining Th(IV), U(IV), Np(N) and Pu(IV) in acid solutions by titration with diethylenetriamine pentacetic acid, the indicator being xylenol orange. It has been established that Th, U, Np and Pu can be determined to within 0.5-1.5%. Th and U in quantities of tens of milligrams can be determined with greater accuracy, attaining hundredths of one per cent. During titration the determination is not hindered by singly- and doubly-charged metal ions, trivalent lanthanides and actinides, except plutonium. The proposed method can be used to determine U(IV) in the presence of considerable quantities of U(VI) and Np(IV) in the presence of Np(V). Total concentrations of uranium or neptunium are determined by reducing uranium (VI) or neptunium (V) by a standard method (for example, using metallic lead, cadmium or zinc amalgam) to the tetravalent state and applying the method described in the paper. (E.P.)

  8. Solubility studies of Np(IV)

    International Nuclear Information System (INIS)

    Zhang Yingjie; Yao Jun; Jiao Haiyang; Ren Lihong; Zhou Duo; Fan Xianhua

    2001-01-01

    The solubility of Np(IV) in simulated underground water and redistilled water has been measured with the variations of pH(6-12) and storage time (0-100 d) in the presence of reductant (Na 2 S 2 O 4 , metallic Fe). All experiments are performed in a low oxygen concentration glove box containing high purity Ar(99.99%), with an oxygen content of less than 5 x 10 -6 mol/mol. Experimental results show that the variation of pH in solution has little effect on the solubility of Np(IV) in the two kinds of water; the measured solubility of Np(IV) is affected by the composition of solution; with Na 2 S 2 O 4 as a reductant, the solubility of Np(IV) in simulated underground water is (9.23 +- 0.48) x 10 -10 mol/L, and that in redistilled water is (8.31 +- 0.35) x 10 -10 mol/L; with metallic Fe as a reductant, the solubility of Np(IV) in simulated underground water is (1.85 +- 0.56) x 10 -9 mol/L, and that in redistilled water is (1.48 +- 0.66) x 10 -9 mol/L

  9. Barriers and attitudes towards hIV Voluntary counselling and Testing ...

    African Journals Online (AJOL)

    Official Publication of the Tanzania Medical Students' Association. 20. Barriers and attitudes towards hIV ... risk reduction in certain groups, behaviour change and reduced transmission2. Young people are the ... Of those who ever used VCT services 32.7% were just interested in knowing their HIV status and to get HIV ...

  10. 75 FR 33761 - Notice of Proposed Change to Section IV of the Virginia State Technical Guide

    Science.gov (United States)

    2010-06-15

    ... revisions made after enactment of the law to NRCS State technical guides used to carry out highly erodible... Section IV of the Virginia State Technical Guide AGENCY: Natural Resources Conservation Service (NRCS), U... NRCS State Technical Guide for review and comment. SUMMARY: It has been determined by the NRCS State...

  11. 75 FR 34974 - Notice of Proposed Change to Section IV of the Virginia State Technical Guide

    Science.gov (United States)

    2010-06-21

    ... revisions made after enactment of the law to NRCS State technical guides used to carry out highly erodible... Section IV of the Virginia State Technical Guide AGENCY: Natural Resources Conservation Service (NRCS), U... NRCS State Technical Guide for review and comment. SUMMARY: It has been determined by the NRCS State...

  12. 75 FR 62759 - Notice of Proposed Change to Section IV of the Virginia State Technical Guide

    Science.gov (United States)

    2010-10-13

    ... revisions made after enactment of the law to NRCS State technical guides used to carry out highly erodible... Section IV of the Virginia State Technical Guide AGENCY: Natural Resources Conservation Service (NRCS), U... NRCS State Technical Guide for review and comment. SUMMARY: It has been determined by the NRCS State...

  13. 75 FR 8508 - Computerized Tribal IV-D Systems and Office Automation

    Science.gov (United States)

    2010-02-25

    ... operating comprehensive Tribal Child Support Enforcement programs under Title IV-D of the Social Security... security and privacy safeguarding requirements reflects our position that security and privacy of child... DEPARTMENT OF HEALTH AND HUMAN SERVICES Administration for Children and Families 45 CFR Parts 309...

  14. Dimensions of normal and abnormal personality: Elucidating DSM-IV personality disorder symptoms in adolescents

    NARCIS (Netherlands)

    Tromp, N.B.; Koot, H.M.

    2010-01-01

    The present study aimed to elucidate dimensions of normal and abnormal personality underlying DSM-IV personality disorder (PD) symptoms in 168 adolescents referred to mental health services. Dimensions derived from the Big Five of normal personality and from Livesley's (2006) conceptualization of

  15. ClinGen Pathogenicity Calculator: a configurable system for assessing pathogenicity of genetic variants.

    Science.gov (United States)

    Patel, Ronak Y; Shah, Neethu; Jackson, Andrew R; Ghosh, Rajarshi; Pawliczek, Piotr; Paithankar, Sameer; Baker, Aaron; Riehle, Kevin; Chen, Hailin; Milosavljevic, Sofia; Bizon, Chris; Rynearson, Shawn; Nelson, Tristan; Jarvik, Gail P; Rehm, Heidi L; Harrison, Steven M; Azzariti, Danielle; Powell, Bradford; Babb, Larry; Plon, Sharon E; Milosavljevic, Aleksandar

    2017-01-12

    The success of the clinical use of sequencing based tests (from single gene to genomes) depends on the accuracy and consistency of variant interpretation. Aiming to improve the interpretation process through practice guidelines, the American College of Medical Genetics and Genomics (ACMG) and the Association for Molecular Pathology (AMP) have published standards and guidelines for the interpretation of sequence variants. However, manual application of the guidelines is tedious and prone to human error. Web-based tools and software systems may not only address this problem but also document reasoning and supporting evidence, thus enabling transparency of evidence-based reasoning and resolution of discordant interpretations. In this report, we describe the design, implementation, and initial testing of the Clinical Genome Resource (ClinGen) Pathogenicity Calculator, a configurable system and web service for the assessment of pathogenicity of Mendelian germline sequence variants. The system allows users to enter the applicable ACMG/AMP-style evidence tags for a specific allele with links to supporting data for each tag and generate guideline-based pathogenicity assessment for the allele. Through automation and comprehensive documentation of evidence codes, the system facilitates more accurate application of the ACMG/AMP guidelines, improves standardization in variant classification, and facilitates collaborative resolution of discordances. The rules of reasoning are configurable with gene-specific or disease-specific guideline variations (e.g. cardiomyopathy-specific frequency thresholds and functional assays). The software is modular, equipped with robust application program interfaces (APIs), and available under a free open source license and as a cloud-hosted web service, thus facilitating both stand-alone use and integration with existing variant curation and interpretation systems. The Pathogenicity Calculator is accessible at http

  16. Characterization of Romboutsia ilealis gen. nov., sp. nov., isolated from the gastro-intestinal tract of a rat, and proposal for the reclassification of five closely related members of the genus Clostridium into the genera Romboutsia gen. nov., Intestinibacter gen. nov., Terrisporobacter gen. nov. and Asaccharospora gen. nov.

    Science.gov (United States)

    Gerritsen, Jacoline; Fuentes, Susana; Grievink, Wieke; van Niftrik, Laura; Tindall, Brian J; Timmerman, Harro M; Rijkers, Ger T; Smidt, Hauke

    2014-05-01

    A Gram-positive staining, rod-shaped, non-motile, spore-forming obligately anaerobic bacterium, designated CRIBT, was isolated from the gastro-intestinal tract of a rat and characterized. The major cellular fatty acids of strain CRIBT were saturated and unsaturated straight-chain C12-C19 fatty acids, with C16:0 being the predominant fatty acid. The polar lipid profile comprised six glycolipids, four phospholipids and one lipid that did not stain with any of the specific spray reagents used. The only quinone was MK-6. The predominating cell-wall sugars were glucose and galactose. The peptidoglycan type of strain CRIBT was A1σ lanthionine-direct. The genomic DNA G+C content of strain CRIBT was 28.1 mol%. On the basis of 16S rRNA gene sequence similarity, strain CRIBT was most closely related to a number of species of the genus Clostridium, including Clostridium lituseburense (97.2%), Clostridium glycolicum (96.2%), Clostridium mayombei (96.2%), Clostridium bartlettii (96.0%) and Clostridium irregulare (95.5%). All these species show very low 16S rRNA gene sequence similarity (genus Clostridium. DNA-DNA hybridization with closely related reference strains indicated reassociation values below 32%. On the basis of phenotypic and genetic studies, a novel genus, Romboutsia gen. nov., is proposed. The novel isolate CRIBT (=DSM 25109T=NIZO 4048T) is proposed as the type strain of the type species, Romboutsia ilealis gen. nov., sp. nov., of the proposed novel genus. It is proposed that C. lituseburense is transferred to this genus as Romboutsia lituseburensis comb. nov. Furthermore, the reclassification into novel genera is proposed for C. bartlettii, as Intestinibacter bartlettii gen. nov., comb. nov. (type species of the genus), C. glycolicum, as Terrisporobacter glycolicus gen. nov., comb. nov. (type species of the genus), C. mayombei, as Terrisporobacter mayombei gen. nov., comb. nov., and C. irregulare, as Asaccharospora irregularis gen. nov., comb. nov. (type species

  17. On the stabilization of niobium(V) solutions by zirconium(IV) and hafnium(IV)

    DEFF Research Database (Denmark)

    Sørensen, E.; Bjerre, A.B.

    1992-01-01

    Niobium cannot be separated from zirconium or hafnium when these elements occur together in solution with common anions such as chloride and sulphate. This is ascribed to the co-polymerization of niobium(V) and the hydrolysed ionic species of zirconium(IV) and hafnium(IV) to form colloidal...

  18. Complexation of the An(IV) by NTA; Complexation des An(IV) par le NTA

    Energy Technology Data Exchange (ETDEWEB)

    Bonin, L. [Paris-11 Univ., 91 - Orsay (France)]|[CEA Valrho, Lab. de Chimie des Actinides (LCA), 30 - Marcoule (France)

    2006-07-01

    In the framework of the Nuclear and Environmental Toxicology program, developed in France, it has been decided to take again the studies concerning the actinides decorporation. A similar study of the neptunium complexation by the citrate ions has been carried out on the complexation of Np(IV) with the nitrilotriacetic acid (NTA). The NTA can be considered as a model molecule of the de-corporating molecules (amino-carboxy- ligand). The results of the spectrophotometric measurements being encouraging, the behaviour of several actinides at the same oxidation state (+IV) (Th(IV), U(IV), Np(IV), and Pu(IV)) has been determined. The experimental results are presented. In order to determine the structure of the complexes of stoichiometry 1:2 An(IV)-(NTA){sub 2} in solution, quantic chemistry calculations and EXAFS measurements have been carried out in parallel. These studies confirm the presence of An(IV)-nitrogen bonds whose length decreases from thorium to plutonium and indicate the presence of a water molecule bound to the thorium and the uranium (coordination number 8 for Np/Pu, 9 for Th/U). The evolution of the complexation constants determined in this study in terms of 1/r (r ionic radius of the cation taking into account its coordination number 8 or 9) confirms the change of the coordination number between Th/U and Np/Pu. (O.M.)

  19. Transuranium perrhenates: Np(IV), Pu(IV) and (III), Am (III)

    International Nuclear Information System (INIS)

    Silvestre, Jean-Paul; Freundlich, William; Pages, Monique

    1977-01-01

    Synthesis in aqueous solution and by solid state reactions, crystallographical characterization and study of the stability of some transuranium perrhenates: Asup(n+)(ReO 4 - )sub(n) (A=Np(IV), Pu(IV), Pu(III), Am(III) [fr

  20. Siamia luxuriosa gen. et sp. nov., a new synnematous hyphomycete from Thailand

    NARCIS (Netherlands)

    Robert, Vincent; Decock, Cony; Castañeda Ruíz, Rafael F.

    2000-01-01

    A new synnematous hyphomycete, Siamia luxuriosa gen. et sp. nov., is described from Khao Yai National Park, Thailand. The genus is characterised by having long, dark synnemata, conidiogenous cells with numerous protuberant, cylindrical, thickened unilaterally arranged scars, and long, slightly

  1. Download - GenLibi | LSDB Archive [Life Science Database Archive metadata

    Lifescience Database Archive (English)

    Full Text Available switchLanguage; BLAST Search Image Search Home About Archive Update History Data ...access [here]. About This Database Database Description Download License Update History of This Database Site Policy | Contact Us Download - GenLibi | LSDB Archive ...

  2. License - GenLibi | LSDB Archive [Life Science Database Archive metadata

    Lifescience Database Archive (English)

    Full Text Available switchLanguage; BLAST Search Image Search Home About Archive Update History Data ...nse Update History of This Database Site Policy | Contact Us License - GenLibi | LSDB Archive ...

  3. Transformação genética em espécies florestais.

    OpenAIRE

    Claudia Studart-Guimarães; Cristiano Lacorte; Ana Cristina Miranda Brasileiro

    2010-01-01

    A transformação genética, que compreende a introdução de genes exógenos de forma controlada no genoma de uma célula vegetal e posterior regeneração da planta transgênica, tem contribuído com os programas de melhoramento genético de plantas pela obtenção de genótipos com novas características de interesse. O melhoramento de espécies florestais é limitado por características intrínsecas a tais espécies, como a altura dos indivíduos e o ciclo longo de vida. A transformação genética constitui, po...

  4. A Software-Assurance Design Approach for NextGen Enabling Technologies, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — The Next Generation Air Transportation System (NextGen) brings significant advancements to the current management of the National Airspace (NAS). These fundamental...

  5. Ekspresi Gen CYP19 Aromatase, Estrogen, Androgen pada penderita Periodontitis Agresif

    Directory of Open Access Journals (Sweden)

    Dahlia Herawati

    2016-11-01

    Full Text Available Kepadatan tulang tubuh ditentukan oleh gen CYP19 aromatase, hormon estrogen dan androgen. Pada periodontitis agresif terjadi perkembangan cepat kerusakan tulang alveolar, dan kerusakan tulang alveoler tersebut tidak diimbangioleh regenerasi tulang. Tujuan penelitian ini adalah menunjukkan ekspresi gen CYP19 aromatase, estrogen, androgen pada penderita periodontitis agresif agar dapat untuk menjadi pertimbangan pada saat melakukan perawatan periodontal. Metode penelitian, pemeriksaan ekspresi gen aromatse CYP19 berasal dari spesimen tulang alveolar menggunakan imunohistokimia, pengukuran hormon estrogen dan androgen dari serum menggunakan Vidas: Elfa. Hasil penelitian ekspresi gene CYP19 aromatase pada periodontitis agresif menunjukkan gambaran lebih rendah densitasnya dibandingkan pada nonperiodontitis. Estrogen dan androgen pad aperiodontitis agresif ada kecenderungan lebih rendah dibandingkan pada nonperiodontitis. Kesimpulan regenerasi tulang alveoler pad a periodontitis agresif terhambat karena sedikitnya gen CYP19 aromatase dan hormon estrogen dan androgen yang berperan pada pembentukan tulang alveoler kurang memadai.

  6. Neofomitella polyzonata gen. et sp. nov., and N. fumosipora and N. rhodophaea transferred from Fomitella

    Czech Academy of Sciences Publication Activity Database

    Li, H.J.; Li, X.C.; Vlasák, Josef; Dai, Y.C.

    2014-01-01

    Roč. 129, č. 1 (2014), s. 7-20 ISSN 0093-4666 Institutional support: RVO:60077344 Keywords : Basidiomycota * phylogeny * polyporaceae * taxonomy Subject RIV: EB - Gen etics ; Molecular Biology Impact factor: 0.705, year: 2014

  7. CLONACIÓN Y FILOGENIA MOLECULAR DE UN SEGMENTO DEL GEN CODANTE DE LA ACTINA DE MYRCIARIA DUBIA “CAMU-CAMU”: UN CANDIDATO PARA GEN DE REFERENCIA

    Directory of Open Access Journals (Sweden)

    Juan Carlos Castro Gómez

    2012-12-01

    Full Text Available Myrciaria dubia “camu-camu” es un frutal amazónico caracterizado por su amplia variación de vitamina C. Pero los estudios genético moleculares que puedan explicar esta variación son limitados. Por ello nuestro objetivo fue realizar la clonación y filogenia molecular de un segmento del gen codante de la actina de M. dubia. Las muestras fueron obtenidas de la colección de germoplasma del INIA. Luego, el ARN fue purificado y mediante RT-PCR con cebadores degenerados se amplificó un segmento del gen. En base a la secuencia obtenida se diseñaron cebadores específicos para PCR en tiempo real. Los resultados muestran que se ha aislado, clonado y secuenciado un segmento del gen codante de actina de M. dubia y detectado su expresión en hojas, pulpa y cáscara de M. dubia. Así, con el soporte de herramientas bioinformáticas y uso de técnicas de biología molecular hemos aislado, clonado y secuenciado un segmento del gen codante de la actina de M. dubia. Asimismo, los análisis realizados muestran que el gen se expresa y presenta niveles similares de expresión en hojas, pulpa y cáscara de M. dubia. Sin embargo, es necesario realizar más experimentos a fin de verificar su estabilidad de expresión.

  8. TRANSFER GEN ANTIVIRUS PADA EMBRIO UDANG WINDU, Penaeus monodon DALAM BERBAGAI KONSENTRASI DEOXYRIBO NUCLEIC ACID

    Directory of Open Access Journals (Sweden)

    Andi Parenrengi

    2011-12-01

    Full Text Available Teknologi transgenesis khususnya rekayasa genetik untuk menghasilkan udang windu resisten penyakit merupakan salah satu strategi yang dapat dilakukan dalam upaya pemecahan masalah penyakit yang menimpa budidaya udang windu. Teknologi transgenesis khususnya transfer gen antivirus pada udang windu telah berhasil dilakukan melalui teknik transfeksi. Meskipun demikian optimalisasi komponen teknologi tersebut masih perlu dilakukan. Konsentrasi DNA gen merupakan salah satu komponen teknologi transgenesis yang harus dioptimalkan untuk mendapatkan efisiensi dalam transfer gen. Penelitian bertujuan untuk mengetahui konsentrasi DNA gen antivirus yang optimal sebagai bahan transfer gen ke embrio menggunakan metode transfeksi. Embrio udang windu yang diperoleh dari hasil pemijahan induk asal Aceh, dikoleksi 5-10 menit setelah memijah dengan kepadatan 625 telur/2 mL. Transfeksi dilakukan dengan menggunakan media larutan transfeksi jetPEI dengan konsentrasi DNA gen antivirus sebagai perlakuan, yakni: 5, 10, dan 15 µg serta kontrol positif (tanpa plasmid DNA dan negatif (tanpa plasmid DNA dan larutan transfeksi, masing-masing 3 ulangan. Embrio hasil transfeksi ditetaskan pada stoples berisi air laut sebanyak 2 L yang diletakkan pada waterbath. Hasil penelitian menunjukkan bahwa gen antivirus telah berhasil diintroduksi ke embrio udang windu. Hasil analisis ragam menunjukkan bahwa perbedaan konsentrasi DNA (5-15 µg tidak berpengaruh nyata (P>0,05 terhadap daya tetas embrio udang windu. Analisis ekspresi gen pada larva udang windu juga menunjukkan adanya aktivitas ekspresi gen antivirus pada semua perlakuan konsentrasi DNA, di mana ekspresi gen antivirus pada larva transgenik lebih tinggi dibandingkan dengan kontrol (tanpa transfeksi. Sintasan pasca-larva PL-1 yang didapatkan pada penelitian ini adalah 12,0%; 10,0%; 10,6%; 12,3%; dan 14,2% masing-masing untuk perlakuan konsentrasi plasmid DNA 5 µg, 10 µg, 15 µg, kontrol positif dan negatif, di mana

  9. KARAKTERISTIK SEKUEN cDNA PENGKODE GEN ANTI VIRUS DARI UDANG WINDU, Penaeus monodon

    Directory of Open Access Journals (Sweden)

    Andi Parenrengi

    2016-11-01

    Full Text Available Transgenesis pada ikan merupakan sebuah teknik modern yang berpotensi besar dalam menghasilkan organisme yang memiliki karakter lebih baik melalui rekombinan DNA gen target termasuk gen anti virus dalam peningkatan resistensi pada udang. Gen anti virus PmAV (Penaeus monodon Anti Viral gene merupakan salah satu gen pengkode anti virus yang berasal dari spesies krustase. Penelitian ini dilakukan untuk mengetahui karakteristik gen anti virus yang diisolasi dari udang windu, Penaeus monodon. Isolasi gen anti virus menggunakan metode Polymerase Chain Reaction (PCR dan selanjutnya dipurifikasi untuk sekuensing. Data yang dihasilkan dianalisis dengan program Genetyx Versi 7 dan basic local alignment search tool (BLAST. Hasil penelitian menunjukkan bahwa gen anti virus PmAV yang berhasil diisolasi dari cDNA udang windu dengan panjang sekuen 520 bp yang mengkodekan 170 asam amino. BLAST-N menunjukkan tingkat similaritas yang sangat tinggi (100% dengan gen anti virus yang ada di GeneBank. Komposisi asam amino penyusun gen anti virus yang paling besar adalah serin (10,00%, sedangkan yang terkecil adalah asam amino prolin dan lisin masing-masing 1,76%. Analisis sekuen gen dan deduksi asam amino (BLAST-P memperlihatkan adanya C-type lectin-like domain (CTLD yang memiliki kemiripan dengan gen C-type lectin yang diisolasi dari beberapa spesies krustase. Transgenic fish technology is a potential modern technique in producing better character organism through DNA recombinant of target genes including anti viral gene for improvement of shrimp immunity. PmAV (Penaeus monodon Anti Viral gene is one of anti viral genes isolated from crustacean species. The research was conducted to analyze the characteristics anti viral gene isolated from tiger prawn, Penaeus monodon. Anti viral gene was isolated using Polymerase Chain Reaction (PCR technique and then purified for sequencing. Data obtained were analyzed using Genetyx Version 7 software and basic local alignment

  10. Oxochloroalkoxide of the Cerium (IV and Titanium (IV as oxides precursor

    Directory of Open Access Journals (Sweden)

    Machado Luiz Carlos

    2002-01-01

    Full Text Available The Cerium (IV and Titanium (IV oxides mixture (CeO2-3TiO2 was prepared by thermal treatment of the oxochloroisopropoxide of Cerium (IV and Titanium (IV. The chemical route utilizing the Cerium (III chloride alcoholic complex and Titanium (IV isopropoxide is presented. The compound Ce5Ti15Cl16O30 (iOPr4(OH-Et15 was characterized by elemental analysis, FTIR and TG/DTG. The X-ray diffraction patterns of the oxides resulting from the thermal decomposition of the precursor at 1000 degreesC for 36 h indicated the formation of cubic cerianite (a = 5.417Å and tetragonal rutile (a = 4.592Å and (c = 2.962 Å, with apparent crystallite sizes around 38 and 55nm, respectively.

  11. Uranium Enrichment Reduction in the Prototype Gen-IV Sodium-Cooled Fast Reactor (PGSFR with PBO Reflector

    Directory of Open Access Journals (Sweden)

    Chihyung Kim

    2016-04-01

    Full Text Available The Korean Prototype Gen-IV sodium-cooled fast reactor (PGSFR is supposed to be loaded with a relatively-costly low-enriched U fuel, while its envisaged transuranic fuels are not available for transmutation. In this work, the U-enrichment reduction by improving the neutron economy is pursued to save the fuel cost. To improve the neutron economy of the core, a new reflector material, PbO, has been introduced to replace the conventional HT9 reflector in the current PGSFR core. Two types of PbO reflectors are considered: one is the conventional pin-type and the other one is an inverted configuration. The inverted PbO reflector design is intended to maximize the PbO volume fraction in the reflector assembly. In addition, the core radial configuration is also modified to maximize the performance of the PbO reflector. For the baseline PGSFR core with several reflector options, the U enrichment requirement has been analyzed and the fuel depletion analysis is performed to derive the equilibrium cycle parameters. The linear reactivity model is used to determine the equilibrium cycle performances of the core. Impacts of the new PbO reflectors are characterized in terms of the cycle length, neutron leakage, radial power distribution, and operational fuel cost.

  12. Deferribacter thermophilus gen. nov., sp. nov., a novel thermophilic manganese- and iron-reducing bacterium isolated from a petroleum reservoir.

    Science.gov (United States)

    Greene, A C; Patel, B K; Sheehy, A J

    1997-04-01

    A thermophilic anaerobic bacterium, designated strain BMAT (T = type strain), was isolated from the production water of Beatrice oil field in the North Sea (United Kingdom). The cells were straight to bent rods (1 to 5 by 0.3 to 0.5 microns) which stained gram negative. Strain BMAT obtained energy from the reduction of manganese (IV), iron(III), and nitrate in the presence of yeast extract, peptone, Casamino Acids, tryptone, hydrogen, malate, acetate, citrate, pyruvate, lactate, succinate, and valerate. The isolate grew optimally at 60 degrees C (temperature range for growth, 50 to 65 degrees C) and in the presence of 2% (wt/vol) NaCl (NaCl range for growth, 0 to 5% [wt/vol]). The DNA base composition was 34 mol% G + C. Phylogenetic analyses of the 16S rRNA gene indicated that strain BMAT is a member of the domain Bacteria. The closest known bacterium is the moderate thermophile Flexistipes sinusarabici (similarity value, 88%). Strain BMAT possesses phenotypic and phylogenetic traits that do not allow its classification as a member of any previously described genus; therefore, we propose that this isolate should be described as a member of a novel species of a new genus, Deferribacter thermophilus gen. nov., sp. nov.

  13. Spectroscopy and chemistry of uranium IV

    International Nuclear Information System (INIS)

    Folcher, G.; Rigny, P.

    1980-06-01

    Different fundamental research papers on uranium IV are presented, some were never edited. Molecular spectroscopy was used for identification and structural study of uranium IV in aqueous or organic solutions. The fields studied are: coordination, stereochemistry, electronic structure and chemical properties. For interpretation of results some studies were made with solid compounds or with thorium compounds or thorium complexes. Knowledge of actinides chemistry is improved, uranium and thorium being models for 5 f ions, extractive chemistry is better understood and new applications are possible [fr

  14. Vectorization at the KENO-IV code

    International Nuclear Information System (INIS)

    Asai, K.; Higuchi, K.; Katakura, J.

    1986-01-01

    The multigroup criticality safety code KENO-IV has been vectorized and tested on the FACOM VP-100 vector processor. At first, the vectorized KENO-IV on a scalar processor was slower than the original one by a factor of 1.4 because of the overhead introduced by vectorization. Making modifications of algorithms and techniques for vectorization, the vectorized version has become faster than the original one by a factor of 1.4 on the vector processor. For further speedup of the code, some improvements on compiler and hardware, especially on addition of Monte Carlo pipelines to the vector processor, are discussed

  15. Functions in Free-Format RPG IV

    CERN Document Server

    Martin, Jim

    2009-01-01

    Written especially for programmers adopting a free-format style, this manual explores the role of functions in writing RPG IV programs. Demonstrating the potential of functions, many topics are explored such as details about existing RPG IV built-in functions, writing new functions, using ILE concepts to use C functions, and utilizing IBM API's functions. Explaining how to write small programs, either as sub-procedures or modules, and how to gather those parts together to make programs that are easy to write and maintain, this is a natural next step for programmers familiar with a free-format

  16. Description of Sharon gen. nov. for the Chilean species Asaphes amoenus Philippi, 1861 (Coleoptera: Elateridae)

    OpenAIRE

    Elizabeth T. Arias-Bohart; Mario Elgueta

    2015-01-01

    Sharon gen. nov. is here described to include Asaphes? amoenus Philippi, 1861 comb. nov. from Chile. A redescription of the species is based on the female holotype and material from different geographic locations. Candèze (1891) placed Asaphes amoenus and Parasaphes elegans in the suprageneric group Asaphites. We discuss differences between Sharon gen. nov. and Hemicrepidius Germar, 1839, where Asaphes amoenus was later placed by Blackwelder (1944). Based on morphological characters, Sharon g...

  17. GenRGenS: Software for Generating Random Genomic Sequences and Structures

    OpenAIRE

    Ponty , Yann; Termier , Michel; Denise , Alain

    2006-01-01

    International audience; GenRGenS is a software tool dedicated to randomly generating genomic sequences and structures. It handles several classes of models useful for sequence analysis, such as Markov chains, hidden Markov models, weighted context-free grammars, regular expressions and PROSITE expressions. GenRGenS is the only program that can handle weighted context-free grammars, thus allowing the user to model and to generate structured objects (such as RNA secondary structures) of any giv...

  18. GenMapDB: a database of mapped human BAC clones

    OpenAIRE

    Morley, Michael; Arcaro, Melissa; Burdick, Joshua; Yonescu, Raluca; Reid, Thomas; Kirsch, Ilan R.; Cheung, Vivian G.

    2001-01-01

    GenMapDB (http://genomics.med.upenn.edu/genmapdb) is a repository of human bacterial artificial chromosome (BAC) clones mapped by our laboratory to sequence-tagged site markers. Currently, GenMapDB contains over 3000 mapped clones that span 19 chromosomes, chromosomes 2, 4, 5, 9–22, X and Y. This database provides positional information about human BAC clones from the RPCI-11 human male BAC library. It also contains restriction fragment analysis data and end sequen...

  19. Medicamentos genéricos y de marca-Calidad e intercambiabilidad

    Directory of Open Access Journals (Sweden)

    Rua F.

    2012-03-01

    Full Text Available El interés por los medicamentos genéricos procede de la necesidad de los sistemas sanitarios de reducir la factura sanitaria sin merma de los objetivos de salud. Su expansión y uso requieren la aceptación de la población y de los profesionales. También requieren que se despejen algunas dudas sobre su verdadera equivalencia respecto a los medicamentos originales. Desde su introducción en el mercado farmacéutico existe el debate de si son correctamente investigados y de alta calidad. No son infrecuentes los conceptos equivocados entre los profesionales sobre los genéricos, en especial, el supuesto hecho de que pueden llegar a contener hasta un 20% menos de concentración en principio activo. Estas creencias erróneas sugieren una situación de desventaja en la eficacia y la tolerabilidad de los medicamentos genéricos comparados con sus equivalentes de marca, disminuyendo la credibilidad de los mismos. Así, en una encuesta realizada en 2008 los farmacéuticos opinaron que los genéricos y las marcas son diferentes en eficacia (26%, equivalencia (28% y, sobre todo, en la calidad del excipiente (46%, aumentando la percepción de que los genéricos son diferentes en función del laboratorio que los fabrica (52,8%. En este artículo, con el fin de ampliar los conocimientos sobre medicamentos genéricos, solucionar dudas y proporcionar información, objetiva, clara y rigurosa, se revisan los posibles prejuicios sobre genéricos y se exponen las evidencias que existen en torno a los mismos, como los requisitos de bioequivalencia de los productos genéricos, analizando si ésta corrobora adecuadamente la equivalencia terapéutica y de intercambio.

  20. Genes and proteins of Escherichia coli K-12 (GenProtEC).

    Science.gov (United States)

    Riley, M

    1997-01-01

    GenProtEC is a database of Escherichia coli genes and their gene products, classified by type of function and physiological role and with citations to the literature for each. Also present are data on sequence similarities amongE.coliproteins with PAM values, percent identity of amino acids, length of alignment and percent aligned. GenProtEC can also be accessed through the World Wide Web at URL http://mbl.edu/html/ecoli.html .

  1. Traffic Generator (TrafficGen) Version 1.4.2: Users Guide

    Science.gov (United States)

    2016-06-01

    the network with Transmission Control Protocol and User Datagram Protocol Internet Protocol traffic. Each node generating network traffic in an...TrafficGen Graphical User Interface (GUI) 3 3.1 Anatomy of the User Interface 3 3.2 Scenario Configuration and MGEN Files 4 4. Working with...for public release; distribution is unlimited. vi List of Figures Fig. 1 TrafficGen user interface

  2. PRODUCTIVE GENERATIONS AND CAREERS: WHAT DO (Y GEN WOMEN WANT?

    Directory of Open Access Journals (Sweden)

    Ana Heloísa Costa Lemos

    2014-07-01

    Full Text Available Despite the attention that Generation Y has received in recent times, studies that map the attitudes related to work of these individuals has devoted little attention to understanding the differences that gender can produce in the same generational group. However, we believe that gender differences should be better understood, because, according to the IBGE (2012, women represent 45.4% of the current Brazilian labor force. The growing importance of women in the labor market brings the challenge for organizations to attract and retain that portion of the workforce, whose demands are not necessarily equal those of men. The scarcity of studies on the expectations related to career of Gen Y women motivated the present work, which sought to understand the desires of young professionals with regard to the construction of their professional careers. To answer these questions we carried out a qualitative research, interviewing young women born between 1980 and 2000. We tried to understand what these professionals expect from its insertion in the labor market. The results confirm the analysis of the descriptions of the recent literature on Yrs, because the interviewees proved eager for success, professional recognition and attractive remuneration, but also highlight differences and indicate some specifics aspects related to the gender considerations, as expressed by these young woman, which expect to lower their work dedication when they become mothers and wives.

  3. De compras por el supermercado genético

    Directory of Open Access Journals (Sweden)

    Singer, Peter

    2002-12-01

    Full Text Available Should we say that selective abortion is a “powerful message that we seek to eliminate future persons”? When deaf parents want to have a deaf children, Are they crazy? Are they advocates of a culture –the Deaf culture? If genetic engineering can give us health, intelligent, and athletic childrens, why say not to this advantages? The aim of this article is not to deal with all objections that could be urged against these options; the purpose is developing a clear understanding of the central values at stake.

    ¿Estamos eliminando una cultura, la de los sordos, cuando tratamos de evitar que nazcan niños sordos? El aborto terapéutico, ¿significa que, por ejemplo, creemos que las vidas de los afectados por síndrome de Down son vidas de menor valor que las vidas “normales”? Si se permitiera la manipulación genética de los embriones ¿sería poco ético encargar hijos guapos y altos? Este artículo no aporta respuestas a estas preguntas, pero sí que plantea los términos para dar cuenta de ellas y eleva acta de lo difícil que es dar una respuesta concluyente.

  4. Université de Genève

    CERN Multimedia

    2008-01-01

    Ecole de physique - Département de physique nucléaire et corspusculaire 24, quai Ernest-Ansermet 1211 GENÈVE 4 Tél: (022) 379 62 73 - Fax: (022) 379 69 92 Lundi 1er décembre 2008 PARTICLE PHYSICS SEMINAR at 17.00 hrs – Stückelberg Auditorium Superconducting Interfaces between Insulating Oxide Prof. Jean-Marc TRISCONE / Université de Genève At interfaces between complex oxides, electronic systems with unusual properties can be generated. A striking example is the interface between LaAlO3 and SrTiO3, two good insulating perovskite oxides, which was found in 2004 to be conducting with a high mobility. We recently discovered that the ground state of this system is a superconducting condensate, with a critical temperature of about 200 mK. The characteristics observed for the superconducting transitions are consistent with a two-dimensional superconducting sheet as thin as a few nanometers. Recent field effect experiments revealed the sensitivity of the normal and superconducting states to the carrier d...

  5. Université de Genève

    CERN Multimedia

    2008-01-01

    Ecole de physique - Département de physique nucléaire et corspusculaire 24, quai Ernest-Ansermet - 1211 GENÈVE 4 Tél: (022) 379 62 73 - Fax: (022) 379 69 92 Lundi 1er décembre 2008 PARTICLE PHYSICS SEMINAR at 17.00 hrs – Stückelberg Auditorium Superconducting Interfaces between Insulating Oxide Prof. Jean-Marc TRISCONE / Université de Genève At interfaces between complex oxides, electronic systems with unusual properties can be generated. A striking example is the interface between LaAlO3 and SrTiO3, two good insulating perovskite oxides, which was found in 2004 to be conducting with a high mobility. We recently discovered that the ground state of this system is a superconducting condensate, with a critical temperature of about 200 mK. The characteristics observed for the superconducting transitions are consistent with a two-dimensional superconducting sheet as thin as a few nanometers. Recent field effect experiments revealed the sensitivity of the normal and superconducting states to the carrier ...

  6. Testes genéticos na eqüideocultura

    Directory of Open Access Journals (Sweden)

    Eduardo Geraldo Alves Coelho

    2008-07-01

    Full Text Available Nos últimos anos a equideocultura deu um salto qualitativo, havendo hoje, no mercado, animais de alto valor e geneticamente superiores. Isso é possível, em grande parte, devido aos avanços na área da genética animal, os quais permitem identificar, não apenas anomalias, mas também diversos genes de interesse econômico. Com o auxílio da citogenética pode-se identificar indivíduos com alterações no número ou na estrutura dos cromossomos, o que em muitos casos afeta principalmente a reprodução. Também a confirmação de genealogia, anteriormente feita por tipagem sangüínea e atualmente por testes de DNA, tem papel extremamente importante, não apenas por garantir a ascendência dos animais, mas também porque um pedigree confiável pode permitir ao criador identificar a origem de problemas genéticos em seu rebanho e reduzi-los ou mesmo, eliminá-los. Ainda com as ferramentas da biologia molecular, podemos hoje, identificar indivíduos que apresentam genes desejáveis ou indesejáveis, o que nos permite selecioná-los precocemente, reduzindo assim, os custos do produtor e aumentando o valor agregado dos animais. Entre tais genes podemos destacar os que identificam portadores ou afetados por mutações genéticas indesejáveis como: SCID (Síndrome da Imunodeficiência Combinada, HYPP (Parilisa Hipercalêmica, HERDA (Astenia Dérmica Regional Hereditária Eqüina, etc. Também a identificação dos genes que determinam a cor ou padrão da pelagem já pode ser feita direta ou indiretamente (por meio de marcadores genéticos, como é o caso dos genes para as pelagens Overo, Tobiano, etc. Com os avanços no estudo do genoma eqüino muito mais estará disponível em breve, o que certamente só trará maiores contribuições à equideocultura mundial.In the last few years the horse breeding industry is achieving significant progresses producing animals of high commercial value and genetically superior. It was possible, mainly due to

  7. Caracterización del gen mecA de Staphylococcus aureus resistentes a meticilina aislados de tres grupos poblacionales de la ciudad de Medellín

    Directory of Open Access Journals (Sweden)

    Marcela Sanchez

    Full Text Available Introducción: Staphylococcus aureus resistente a la meticilina (SARM es responsable de infecciones intrahospitalarias, las que constituyen una importante causa de morbilidad y mortalidad en nuestro medio, por lo cual la rápida identificación y tipificación molecular de la resistencia como el complejo SSCmec es esencial para entender la epidemiología de la infección. Objetivo: Caracterizar fenotípicamente la resistencia a meticilina y genotípicamente el casete cromosomal SSCmec en cepas de S. aureus aislados de individuos de la ciudad de Medellín mediante PCR múltiple. Materiales y métodos: A 41 aislamientos (hospitalarios y de la comunidad de S. aureus se les estableció la resistencia a cefoxitin mediante la técnica de Kirby-Bauer y la concentración inhibitoria mínima para oxacilina. Mediante PCR convencional se les confirmó la presencia del gen mecA. Para la tipificación del complejo SSCmec se utilizó PCR múltiple para amplificar 6 loci diferentes de este gen. Resultados: A todos los aislamientos se les confirmó resistencia a meticilina y la presencia del gen mecA, de los cuales 17 fueron clasificados como SSC mec I, 1 como SSC mec II, 21 como SSC mecIV; dos aislamientos no fue posible clasificarlos. Conclusiones: Con el uso de esta técnica clasificamos el 95% de los aislamientos del estudio, encontrando una mayor prevalencia de los SSCmec I y IV. La implementación de esta técnica permite una fácil caracterización de los aislamientos SARM y un apropiado manejo de la información de los integrantes de los comités de infecciones hospitalarios, lo cual podría impactar positivamente en el tratamiento a los pacientes y el control de enfermedades infecciosas intrahospitalarias.

  8. NextGen Weather Plan, Version 1.1

    Science.gov (United States)

    2009-09-17

    to-point transport of the weather products. Some data such as the Aviation Digital Data Service (ADDS) are also available via access to special web ...Aeronautics and Space Administration NCV National Ceiling & Visibility NDFD National Digital Forecast Database NEO Net Enabled Operations NEVS Network...World Area Forecast Center WAFS World Area Forecast System WBS Work Breakdown Structure WCS Web Coverage Service WFS Web Feature Service Wx Weather

  9. Bis(4-methylpiperidinium hexachloridostannate(IV

    Directory of Open Access Journals (Sweden)

    Madeleine Helliwell

    2008-04-01

    Full Text Available The crystal structure of the title compound, (C6H14N2[SnCl6], is built of 4-methylpiperidinium cations, occupying special positions on the mirror plane, and hexachloridostannate(IV anions on a special position of 2/m symmetry. The ions are linked via N—H...Cl hydrogen bonds into chains running along the b axis.

  10. The carbonate complexation of plutonium(IV)

    International Nuclear Information System (INIS)

    Hobart, D.E.; Palmer, P.D.; Newton, T.W.

    1985-01-01

    Plutonium(IV) carbonate complexes are expected to be of particular importance in typical groundwaters at the Yucca Mountain site of the candidate nuclear waste repository being studied by the Nevada Nuclear Waste Storage Investigations Project. The chemistry of these complexes is also important in the areas of nuclear fuel reprocessing and purification, actinide separations, and environmental studies. This report describes initial experiments performed to determine the identity and equilibrium quotients of plutonium(IV) carbonate complexes. These experiments were performed at pH values between 7.2 and 9.6 using a spectrophotometric method. In addition, a brief review of the published literature on Pu(IV) carbonate complexes is presented. Since Pu(IV) exhibits low solubility in the near-neutral pH range, a complex-competition reaction where citrate ligands compete with carbonate ions for the plutonium will be employed. This will permit us to study the pure carbonate system; study the mixed carbonate/citrate system, and confirm and extend the literature work on the pure citrate system. The current experiments have demonstrated the existence of at least three distinct species in the pH region studied. This work will continue in the extended study of the pure citrate system, followed by the investigation of the citrate/carbonate complex/competition reaction. 9 refs., 4 figs., 2 tabs

  11. Painlevé IV coherent states

    International Nuclear Information System (INIS)

    Bermudez, David; Contreras-Astorga, Alonso; Fernández C, David J.

    2014-01-01

    A simple way to find solutions of the Painlevé IV equation is by identifying Hamiltonian systems with third-order differential ladder operators. Some of these systems can be obtained by applying supersymmetric quantum mechanics (SUSY QM) to the harmonic oscillator. In this work, we will construct families of coherent states for such subset of SUSY partner Hamiltonians which are connected with the Painlevé IV equation. First, these coherent states are built up as eigenstates of the annihilation operator, then as displaced versions of the extremal states, both involving the related third-order ladder operators, and finally as extremal states which are also displaced but now using the so called linearized ladder operators. To each SUSY partner Hamiltonian corresponds two families of coherent states: one inside the infinite subspace associated with the isospectral part of the spectrum and another one in the finite subspace generated by the states created through the SUSY technique. - Highlights: • We use SUSY QM to obtain Hamiltonians with third-order differential ladder operators. • We show that these systems are related with the Painlevé IV equation. • We apply different definitions of coherent states to these Hamiltonians using the third-order ladder operators and some linearized ones. • We construct families of coherent states for such systems, which we called Painlevé IV coherent states

  12. Resonance transition array of Yb IV

    International Nuclear Information System (INIS)

    Kaufman, V.; Sugar, J.

    1976-01-01

    Nineteen pairs of lines in the wavelength range of 800--1300 A were identified as transitions to the two levels of the ground term of Yb IV, 4f 13 2 F. The 2 F 5 / 2 -- 2 F 7 / 2 interval is 10 214.0 cm -1 with an rms deviation of 0.4 cm -1

  13. Industrial Waste Landfill IV upgrade package

    International Nuclear Information System (INIS)

    1994-01-01

    The Y-12 Plant, K-25 Site, and ORNL are managed by DOE's Operating Contractor (OC), Martin Marietta Energy Systems, Inc. (Energy Systems) for DOE. Operation associated with the facilities by the Operating Contractor and subcontractors, DOE contractors and the DOE Federal Building result in the generation of industrial solid wastes as well as construction/demolition wastes. Due to the waste streams mentioned, the Y-12 Industrial Waste Landfill IV (IWLF-IV) was developed for the disposal of solid industrial waste in accordance to Rule 1200-1-7, Regulations Governing Solid Waste Processing and Disposal in Tennessee. This revised operating document is a part of a request for modification to the existing Y-12 IWLF-IV to comply with revised regulation (Rule Chapters 1200-1-7-.01 through 1200-1-7-.08) in order to provide future disposal space for the ORR, Subcontractors, and the DOE Federal Building. This revised operating manual also reflects approved modifications that have been made over the years since the original landfill permit approval. The drawings referred to in this manual are included in Drawings section of the package. IWLF-IV is a Tennessee Department of Environmental and Conservation/Division of Solid Waste Management (TDEC/DSWM) Class 11 disposal unit

  14. IV-DSA of vertigo patients

    International Nuclear Information System (INIS)

    Watanabe, Hiromi; Ito, Masatoshi; Takita, Kimio; Matsuzawa, Taiju.

    1988-01-01

    With IV-DSA(Intra-Venous Digital Subtraction Angiography), we examined the relations between vertigo or dizziness and asymmetries of cervical vertebral arteries. In this time, as the asymmetries we chose next three; hemi-stenosis, hemi-occulusion and hemi-strong tortuosity. In the appearance of the asymmetries, there was no differance between those who complain vertigo or dizziness and others. (author)

  15. 21 CFR 1308.14 - Schedule IV.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 9 2010-04-01 2010-04-01 false Schedule IV. 1308.14 Section 1308.14 Food and... isomers is possible: (1) Fenfluramine 1670 (e) Stimulants. Unless specifically excepted or unless listed... the following substances having a stimulant effect on the central nervous system, including its salts...

  16. Painlevé IV coherent states

    Energy Technology Data Exchange (ETDEWEB)

    Bermudez, David, E-mail: david.bermudez@weizmann.ac.il [Department of Physics of Complex Systems, Weizmann Institute of Science, Rehovot 76100 (Israel); Departamento de Física, Cinvestav, A.P. 14-740, 07000 México D.F. (Mexico); Contreras-Astorga, Alonso, E-mail: aloncont@iun.edu [Department of Mathematics and Actuarial Science, Indiana University Northwest, 3400 Broadway, Gary IN 46408 (United States); Departamento de Física, Cinvestav, A.P. 14-740, 07000 México D.F. (Mexico); Fernández C, David J., E-mail: david@fis.cinvestav.mx [Departamento de Física, Cinvestav, A.P. 14-740, 07000 México D.F. (Mexico)

    2014-11-15

    A simple way to find solutions of the Painlevé IV equation is by identifying Hamiltonian systems with third-order differential ladder operators. Some of these systems can be obtained by applying supersymmetric quantum mechanics (SUSY QM) to the harmonic oscillator. In this work, we will construct families of coherent states for such subset of SUSY partner Hamiltonians which are connected with the Painlevé IV equation. First, these coherent states are built up as eigenstates of the annihilation operator, then as displaced versions of the extremal states, both involving the related third-order ladder operators, and finally as extremal states which are also displaced but now using the so called linearized ladder operators. To each SUSY partner Hamiltonian corresponds two families of coherent states: one inside the infinite subspace associated with the isospectral part of the spectrum and another one in the finite subspace generated by the states created through the SUSY technique. - Highlights: • We use SUSY QM to obtain Hamiltonians with third-order differential ladder operators. • We show that these systems are related with the Painlevé IV equation. • We apply different definitions of coherent states to these Hamiltonians using the third-order ladder operators and some linearized ones. • We construct families of coherent states for such systems, which we called Painlevé IV coherent states.

  17. National Coastal Condition Report IV (2012)

    Science.gov (United States)

    The NCCR IV data shows an overall condition score of 3.0 for the nation’s coastal waters; although this score has improved substantially since 1990, the overall condition of the nation’s coastal resources continues to be rated fair.

  18. Scylla IV-P theta pinch

    International Nuclear Information System (INIS)

    Bailey, A.G.; Chandler, G.I.; Ekdahl, C.A. Jr.; Lillberg, J.W.; Machalek, M.D.; Seibel, F.T.

    1976-01-01

    Scylla IV-P is a flexible, linear theta pinch designed to investigate high-density linear concepts, end-stoppering, alternate heating methods, and plasma injection techniques relevant to a pure fusion reactor and/or a fusion-fission hybrid system. The construction and experimental arrangement of the device are briefly described

  19. Coordination and solvent extraction behaviour of oxozirconium(IV), thorium(IV) and dioxouranium(VI)

    International Nuclear Information System (INIS)

    Dash, K.C.

    1989-01-01

    The systematic liquid-liquid extraction behaviour of oxozirconium (IV), thorium(IV) and dioxouranium(VI) have been investigated using a number of synthesised and commercial chelating extractants. The synergism or antagonism for these processes in presence of neutral donor ligands have also been identified and the conditions for separation and isolation of pure individual metal ions have been established. The coordination behaviour of oxozirconium(IV), thorium(IV) and dioxouranium(VI) with a large number of mono- and polydentate ligands have been studied. With oxozirconium(IV), invariably always a cyclic, tetranuclear species is obtained, derived from the tetrameric structure of the parent ZrOCl 2 .8H 2 O which is actually (Zr 4 (OH) 8 (H 2 O) 16 )Cl 8 .12H 2 O. No simple, monomeric oxozirconium(IV) complex was obtained. Uranium(VI) and thorium(IV) form a wide variety of complexes of higher coordination numbers and several bi- and trinuclear complexes were also characterised where the two adjacent metal centres are joined to each other by a double hydroxo-bridge. (author). 69 refs., 3 figs., 4 tabs

  20. Ehlers-Danlos syndrome type IV

    Directory of Open Access Journals (Sweden)

    Germain Dominique P

    2007-07-01

    Full Text Available Abstract Ehlers-Danlos syndrome type IV, the vascular type of Ehlers-Danlos syndromes (EDS, is an inherited connective tissue disorder defined by characteristic facial features (acrogeria in most patients, translucent skin with highly visible subcutaneous vessels on the trunk and lower back, easy bruising, and severe arterial, digestive and uterine complications, which are rarely, if at all, observed in the other forms of EDS. The estimated prevalence for all EDS varies between 1/10,000 and 1/25,000, EDS type IV representing approximately 5 to 10% of cases. The vascular complications may affect all anatomical areas, with a tendency toward arteries of large and medium diameter. Dissections of the vertebral arteries and the carotids in their extra- and intra-cranial segments (carotid-cavernous fistulae are typical. There is a high risk of recurrent colonic perforations. Pregnancy increases the likelihood of a uterine or vascular rupture. EDS type IV is inherited as an autosomal dominant trait that is caused by mutations in the COL3A1 gene coding for type III procollagen. Diagnosis is based on clinical signs, non-invasive imaging, and the identification of a mutation of the COL3A1 gene. In childhood, coagulation disorders and Silverman's syndrome are the main differential diagnoses; in adulthood, the differential diagnosis includes other Ehlers-Danlos syndromes, Marfan syndrome and Loeys-Dietz syndrome. Prenatal diagnosis can be considered in families where the mutation is known. Choriocentesis or amniocentesis, however, may entail risk for the pregnant woman. In the absence of specific treatment for EDS type IV, medical intervention should be focused on symptomatic treatment and prophylactic measures. Arterial, digestive or uterine complications require immediate hospitalisation, observation in an intensive care unit. Invasive imaging techniques are contraindicated. Conservative approach is usually recommended when caring for a vascular

  1. Ehlers-Danlos syndrome type IV

    Science.gov (United States)

    Germain, Dominique P

    2007-01-01

    Ehlers-Danlos syndrome type IV, the vascular type of Ehlers-Danlos syndromes (EDS), is an inherited connective tissue disorder defined by characteristic facial features (acrogeria) in most patients, translucent skin with highly visible subcutaneous vessels on the trunk and lower back, easy bruising, and severe arterial, digestive and uterine complications, which are rarely, if at all, observed in the other forms of EDS. The estimated prevalence for all EDS varies between 1/10,000 and 1/25,000, EDS type IV representing approximately 5 to 10% of cases. The vascular complications may affect all anatomical areas, with a tendency toward arteries of large and medium diameter. Dissections of the vertebral arteries and the carotids in their extra- and intra-cranial segments (carotid-cavernous fistulae) are typical. There is a high risk of recurrent colonic perforations. Pregnancy increases the likelihood of a uterine or vascular rupture. EDS type IV is inherited as an autosomal dominant trait that is caused by mutations in the COL3A1 gene coding for type III procollagen. Diagnosis is based on clinical signs, non-invasive imaging, and the identification of a mutation of the COL3A1 gene. In childhood, coagulation disorders and Silverman's syndrome are the main differential diagnoses; in adulthood, the differential diagnosis includes other Ehlers-Danlos syndromes, Marfan syndrome and Loeys-Dietz syndrome. Prenatal diagnosis can be considered in families where the mutation is known. Choriocentesis or amniocentesis, however, may entail risk for the pregnant woman. In the absence of specific treatment for EDS type IV, medical intervention should be focused on symptomatic treatment and prophylactic measures. Arterial, digestive or uterine complications require immediate hospitalisation, observation in an intensive care unit. Invasive imaging techniques are contraindicated. Conservative approach is usually recommended when caring for a vascular complication in a patient suffering

  2. ASTRID, Generation IV advanced sodium technological reactor for industrial demonstration

    International Nuclear Information System (INIS)

    Gauche, F.

    2013-01-01

    ASTRID (Advanced Sodium Technological Reactor for Industrial Demonstration) is an integrated technology demonstrator designed to demonstrate the operability of the innovative choices enabling fast neutron reactor technology to meet the Generation IV criteria. ASTRID is a sodium-cooled fast reactor with an electricity generating power of 600 MWe. In order to meet the generation IV goals, ASTRID will incorporate the following decisive innovations: -) an improved core with a very low, even negative void coefficient; -) the possible installation of additional safety devices in the core. For example, passive anti-reactivity insertion devices are explored; -) more core instrumentation; -) an energy conversion system with modular steam generators, to limit the effects of a possible sodium-water reaction, or sodium-nitrogen exchangers; -) considerable thermal inertia combined with natural convection to deal with decay heat; -)elimination of major sodium fires by bunkerization and/or inert atmosphere in the premises; -) to take into account off-site hazards (earthquake, airplane crash,...) right from the design stage; -) a complete rethink of the reactor architecture in order to limit the risk of proliferation. ASTRID will also include systems for reducing the length of refueling outages and increasing the burn-up and the duration of the cycle. In-service inspection, maintenance and repair are also taken into account right from the start of the project. The ASTRID prototype should be operational by about 2023. (A.C.)

  3. Programa nacional de prevención y consejería genética del retinoblastoma mediante detección de mutaciones en el gen RB.

    Directory of Open Access Journals (Sweden)

    H. Frayle

    2001-07-01

    una la doble mutación inactivante del gen Rb, exclusivamente somática en los esporádicos y germinal más somática en los hereditarios. Esta investigacin tuvo como objetivo caracterizar las mutaciones en el gen Rb mediante secuenciación directa y evaluar su utilidad en la consejería genética.

  4. Enfermedades genéticas más frecuentes en pacientes atendidos en consulta de genética clínica

    Directory of Open Access Journals (Sweden)

    Elibett Carcasés Carcasés

    2015-02-01

    Full Text Available La estimación de la prevalencia de las enfermedades genéticas se dificulta, entre otras causas, por su rareza. Se realizó un estudio descriptivo retrospectivo, para identificar las enfermedades genéticas de mayor prevalencia en pacientes atendidos por este programa en el Centro Provincial de Genética Médica de Las Tunas, Cuba; desde el año 1989 hasta julio de 2014. Se revisaron todas las historias clínicas. Predominó el origen monogénico (69 %, siendo los síndromes dismórficos los más numerosos y diversos, entre ellos los neurocutáneos, que representaron el 35 %. La enfermedad genética monogénica con mayor número de casos fue la Neurofibromatosis I con el 14,4 % y el 22,2 % de las enfermedades eran de origen monogénico y dismórfico. La Trisomía 21 representó el 77 % de la causa cromosómica. En el origen multifactorial prevalecieron los defectos congénitos mayores, entre ellos los defectos reductivos de miembros (27 %

  5. Genética de la preeclampsia: una aproximación a los estudios de ligamiento genético.

    Directory of Open Access Journals (Sweden)

    Nora Alejandra Zuluaga

    2004-06-01

    Full Text Available La preeclampsia es considerada un problema de salud pública debido a su alta prevalencia. Muchas investigaciones coinciden en que su origen se relaciona con la interacción entre factores genéticos y ambientales. Por esta razón, múltiples estudios han explorado tales factores genéticos tratando de identificar regiones cromosómicas y genes candidatos cuyas variantes se relacionen con una mayor susceptibilidad a la enfermedad. Diversos estudios de asociación han identificado algunos genes de susceptibilidad a la preeclampsia, pero los resultados no se han replicado consistentemente en todas las poblaciones, quizá por su complejidad clínica y genética. El levantamiento de mapas de genes y regiones cromosómicas basado en análisis de ligamiento ha mostrado resultados interesantes con algunos marcadores en los cromosomas 2 y 4. En este sentido, hay muchas expectativas con respecto a los genes localizados en tales regiones candidatas, debido a que la identificación de los factores de riesgo genético podría ayudar al entendimiento de esta condición y en proveer claves para su prevención y tratamiento.

  6. Marinagarivorans algicola gen. nov., sp. nov., isolated from marine algae.

    Science.gov (United States)

    Guo, Ling-Yun; Li, Dong-Qi; Sang, Jin; Chen, Guan-Jun; Du, Zong-Jun

    2016-03-01

    Two novel agar-degrading, Gram-stain-negative, motile, heterotrophic, facultatively anaerobic and pale yellow-pigmented bacterial strains, designated Z1 T and JL1, were isolated from marine algae Gelidium amansii (Lamouroux) and Gracilaria verrucosa , respectively. Growth of the isolates was optimal at 28-30 °C, pH 7.0-7.5 and with 2-3 % (w/v) NaCl. Both strains contained Q-8 as the sole respiratory quinone. The major cellular fatty acids in strain Z1 T were C 18 : 1 ω7 c , C 16 : 0 and summed feature 3 (C 16 : 1 ω7 c and/or iso-C 15 : 0 2-OH). The predominant polar lipids in strain Z1 T were phosphatidylethanolamine, phosphatidylglycerol and an aminolipid. The genomic DNA G+C content of both strains was 45.1 mol%. Strains Z1 T and JL1 were closely related, with 99.9 % 16S rRNA gene sequence similarity. The average nucleotide identity (ANI) value between strains Z1 T and JL1 was 99.3 %. Phylogenetic analysis based on 16S rRNA gene sequences revealed that strains Z1 T and JL1 form a distinct phyletic line within the class Gammaproteobacteria , with less than 92.3 % similarity to their closest relatives. Based on data from the current polyphasic study, the isolates are proposed to belong to a novel species of a new genus designated Marinagarivorans algicola gen. nov., sp. nov. The type strain of the type species is Z1 T ( = ATCC BAA-2617 T  = CICC 10859 T ).

  7. Rhabdobacter roseus gen. nov., sp. nov., isolated from soil.

    Science.gov (United States)

    Dahal, Ram Hari; Kim, Jaisoo

    2016-01-01

    An aerobic, Gram-stain-negative, oxidase- and catalase-positive, non-motile, non-spore-forming, rod-shaped, pink-pigmented bacterium, designated strain R49T, was isolated from soil. Flexirubin-type pigments were absent. Phylogenetic analysis based on its 16S rRNA gene sequence revealed that strain R49T formed a lineage within the family Cytophagaceae of the phylum Bacteroidetes that was distinct from the most closely related genera Dyadobacter (91.98-93.85 % sequence similarity), Persicitalea (88.69 %) and Runella (84.79-85.81 %). The major isoprenoid quinone was menaquinone-7 (MK-7) and the major polar lipid was phosphatidylethanolamine. The major cellular fatty acids were summed feature 3 (C16 : 1ω7c and/or C16 : 1ω6c), iso-C15 : 0, C16 : 1ω5c, C16 : 0 and iso-C17 : 0 3-OH. The DNA G+C content of strain R49T was 53.9 mol%. On the basis of phenotypic, genotypic and phylogenetic analysis, strain R49T represents a novel species of a new genus in the family Cytophagaceae, for which the name Rhabdobacter roseus gen. nov., sp. nov. is proposed. The type strain of Rhabdobacter roseus is R49T ( = KEMB 9005-318T = KACC 18395T = JCM 30685T).

  8. Programa nacional de prevención y consejería genética del retinoblastoma mediante detección de mutaciones en el gen rb.

    OpenAIRE

    Frayle, H.; Guevara, G.

    2011-01-01

    El retinoblastoma es un raro tumor ocular que se diagnostica en los niños, 40% de los casos se consideran hereditarios y 60% esporádicos. El modelo genético propuesto por Knudson involucra
    una la doble mutación inactivante del gen Rb, exclusivamente somática en los esporádicos y germinal más somática en los hereditarios. Esta investigacin tuvo como objetivo caracterizar las mutaciones en el gen Rb mediante secuenciación directa y evaluar su utilidad en la consejería genética....

  9. Development and design application of cerium (IV) decontamination process

    International Nuclear Information System (INIS)

    Bray, L.A.; Seay, J.M.

    1988-01-01

    A simple and effective method was developed for decontamination of high-level waste canisters. This method of chemical decontamination is applicable to a wide variety of contaminated equipment found in the nuclear industry. Conceptual design of the cerium [Ce(IV)] decontamination process equipment has been completed for the West Valley Demonstration project (WVDP) vitrification facility. This remote equipment, which is the first engineering scale application of this technology, will remove surface contamination from stainless-steel (SS) containers containing high-level waste (HLW) glass prior to placing them into temporary storage and ultimate shipment to a U.S. Department of Energy (DOE) repository for disposal. The objective of the development and design study was to identify an effective chemical process and to design equipment to decontaminate the HLW glass canisters to limits that meet U.S. DOE requirements. The equipment includes canister-capping and smear stations in addition to the decontamination module and associated services

  10. Development and design application of cerium (IV) decontamination process

    International Nuclear Information System (INIS)

    Bray, L.A.; Seay, J.M.

    1988-10-01

    A simple and effective method was developed for decontamination of high-level waste canisters. This method of chemical decontamination is applicable to a wide variety of contaminated equipment found in the nuclear industry. Conceptual design of the cerium [Ce(IV)] decontamination process equipment has been completed for the West Valley Demonstration Project (WVDP) vitrification facility. This remote equipment, which is the first engineering scale application of this technology, will remove surface contamination from stainless-steel (SS) containers containing high-level waste (HLW) glass prior to placing them into temporary storage and ultimate shipment to a US Department of Energy (DOE) repository for disposal. The objective of the development and design study was to identify an effective chemical process and to design equipment to decontaminate the HLW glass canisters to limits that meet USDOE requirements. The equipment includes canister-capping and smear stations in addition to the decontamination module and associated services. 2 refs., 1 fig

  11. Primary Tumor Thickness is a Prognostic Factor in Stage IV Melanoma: A Retrospective Study of Primary Tumor Characteristics.

    Science.gov (United States)

    Luen, Stephen; Wong, Siew Wei; Mar, Victoria; Kelly, John W; McLean, Catriona; McArthur, Grant A; Haydon, Andrew

    2018-01-01

    Stage IV melanoma exhibits a diverse range of tumor biology from indolent to aggressive disease. Many important prognostic factors have already been identified. Despite this, the behavior of metastatic melanoma remains difficult to predict. We sought to determine if any primary tumor characteristics affect survival following the diagnosis of stage IV melanoma. All patients diagnosed with stage IV melanoma between January 2003 and December 2012 were identified from the Victorian Melanoma Service database. Retrospective chart review was performed to collect data on primary tumor characteristics (thickness, ulceration, mitotic rate, melanoma subtype, or occult primary). Known and suspected prognostic factors were additionally collected (time to diagnosis of stage IV disease, age, sex, stage, receipt of chemotherapy, and era of recurrence). The effect of primary tumor characteristics on overall survival from the date of diagnosis of stage IV disease was assessed. A total of 227 patients with a median follow-up of 5 years from diagnosis of stage IV disease were identified. Median overall survival of the cohort was 250 days.Of the primary tumor characteristics assessed, only tumor thickness affected survival from diagnosis of stage IV disease, hazard ratio=1.09 (1.02 to 1.16), P=0.008. This remained significant in multivariate analysis, P=0.007. Other primary tumor characteristics did not significantly influence survival. Primary tumor thickness is a significant prognostic factor in stage IV melanoma. Our data suggest that the biology of the primary melanoma may persist to influence the behavior of metastatic disease.

  12. Genética em transtornos alimentares: ampliando os horizontes de pesquisa

    Directory of Open Access Journals (Sweden)

    Pinheiro Andréa Poyastro

    2006-01-01

    Full Text Available OBJETIVO: Revisar a literatura atual concernente à pesquisa genética em transtornos do comportamento alimentar e discutir questões relevantes ao desenvolvimento de um projeto de pesquisa genética nessa área no Brasil. MÉTODO: A revisão realizada utilizou a base de dados Medline, no período de 1984 a maio de 2005, com os seguintes termos de busca: "anorexia nervosa", "bulimia nervosa", "eating disorders", "binge eating disorder", "family studies", "twin studies", "molecular genetics studies". RESULTADOS: Os dados atuais apontam para uma contribuição relevante dos fatores genéticos na suscetibilidade à anorexia e à bulimia nervosa. A pesquisa genética com populações miscigenadas deve levar em consideração o tamanho da amostra, a densidade de genotipagem e a estratificação populacional. Através de "admixture mapping" é possível estimar a estrutura genética destas populações e localizar genes relacionados à variação étnica de doenças ou traços de interesse. CONCLUSÕES: O desenvolvimento de uma grande iniciativa de colaboração em genética de transtornos alimentares no Brasil e na América Latina viabilizará estudar os fatores genéticos em transtornos do comportamento alimentar no contexto de grupos inter-étnicos, e integrar uma nova perspectiva biológica à etiologia destes distúrbios.

  13. Salud pública, genética y ética

    Directory of Open Access Journals (Sweden)

    Kottow Miguel H

    2002-01-01

    Full Text Available La investigación genética ha tenido una enorme expansión en recientes décadas, con repercusiones terapéuticas aún inciertas. El análisis bioético tradicional de las complejas prácticas genéticas ha sido insuficiente por sostenerse en la ética de la investigación y en la bioética de corte principialista. Los problemas éticos más importantes de la genética son de orden colectivo y deben ser abordados por una reflexión ético-social cuyo enfoque es más amplio que la agenda interpersonal del principialismo. Temas como exploraciones genéticas, cuestiones patrimoniales, manipulación génica y asignación de recursos, deben todos ser sometidos a un pensamiento inspirado en los requerimientos de la ciudadanía, en el bien común y en la definición del rol del Estado en fiscalizar actividades genéticas y en proteger a la población. El objetivo del estudio es mostrar cómo el amplio campo de la ética y de la genética tiene una mayor relevancia en el campo social que en el clínico. El objetivo del trabajo es señalar que la bioética principialista ha enfatizado los problemas éticos individuales que nacen con la intervención genética, a costa de marginar sus importantes repercusiones sociales.

  14. Salud pública, genética y ética

    Directory of Open Access Journals (Sweden)

    Miguel H Kottow

    2002-10-01

    Full Text Available La investigación genética ha tenido una enorme expansión en recientes décadas, con repercusiones terapéuticas aún inciertas. El análisis bioético tradicional de las complejas prácticas genéticas ha sido insuficiente por sostenerse en la ética de la investigación y en la bioética de corte principialista. Los problemas éticos más importantes de la genética son de orden colectivo y deben ser abordados por una reflexión ético-social cuyo enfoque es más amplio que la agenda interpersonal del principialismo. Temas como exploraciones genéticas, cuestiones patrimoniales, manipulación génica y asignación de recursos, deben todos ser sometidos a un pensamiento inspirado en los requerimientos de la ciudadanía, en el bien común y en la definición del rol del Estado en fiscalizar actividades genéticas y en proteger a la población. El objetivo del estudio es mostrar cómo el amplio campo de la ética y de la genética tiene una mayor relevancia en el campo social que en el clínico. El objetivo del trabajo es señalar que la bioética principialista ha enfatizado los problemas éticos individuales que nacen con la intervención genética, a costa de marginar sus importantes repercusiones sociales.

  15. Mejoramiento genético acelerado de angiospermas perennes vía inducción floral por sobre-expresión del gen FT

    Directory of Open Access Journals (Sweden)

    Rafael Urrea López

    2018-05-01

    Full Text Available Los bosques y selvas enfrentan el reto de satisfacer la demanda por recursos de una población en crecimiento, así como la amenaza del rápido cambio climático que exacerba la magnitud y frecuencia de estreses bióticos y abióticos. Para ello, es urgente acelerar el mejoramiento genético de especies forestales. Sin embargo, sus largas etapas juveniles y asincronía floral retrasan peligrosamente este proceso. El presente ensayo explora los adelantos biotecnológicos en inducción floral y su potencial aplicación en especies forestales. Entre los genes identificados y caracterizados que participan en la ruta de señalización de la floración, especial atención se destina al gen FLOWERING LOCUS T, considerado un integrador de rutas de señalización altamente conservado entre las angiospermas, que, al sobre-expresarse por ingeniería genética, es capaz de inducir la floración de forma eficiente. Esta novedosa estrategia biotecnológica se ha utilizado, recientemente, para segregar genes de resistencia a enfermedades, en un menor tiempo, en germoplasma comercial de manzana y ciruela. Permite soslayar barreras naturales que por mucho tiempo han restringido a las especies forestales al mejoramiento por selección, principalmente. Entre sus ventajas está la de poder restringirla al proceso y no al producto, para acelerar las cruzas sexuales sin modificar genéticamente la progenie; se aleja así de la controversia alrededor de la liberación y consumo de organismos genéticamente modificados, y de los costos y trámites obligatorios para los OGM para monitoreo de posibles riesgos. Se proyecta como una tecnología que puede acelerar, significativamente, el mejoramiento de especies forestales.

  16. Feasibility of a Networked Air Traffic Infrastructure Validation Environment for Advanced NextGen Concepts

    Science.gov (United States)

    McCormack, Michael J.; Gibson, Alec K.; Dennis, Noah E.; Underwood, Matthew C.; Miller,Lana B.; Ballin, Mark G.

    2013-01-01

    Abstract-Next Generation Air Transportation System (NextGen) applications reliant upon aircraft data links such as Automatic Dependent Surveillance-Broadcast (ADS-B) offer a sweeping modernization of the National Airspace System (NAS), but the aviation stakeholder community has not yet established a positive business case for equipage and message content standards remain in flux. It is necessary to transition promising Air Traffic Management (ATM) Concepts of Operations (ConOps) from simulation environments to full-scale flight tests in order to validate user benefits and solidify message standards. However, flight tests are prohibitively expensive and message standards for Commercial-off-the-Shelf (COTS) systems cannot support many advanced ConOps. It is therefore proposed to simulate future aircraft surveillance and communications equipage and employ an existing commercial data link to exchange data during dedicated flight tests. This capability, referred to as the Networked Air Traffic Infrastructure Validation Environment (NATIVE), would emulate aircraft data links such as ADS-B using in-flight Internet and easily-installed test equipment. By utilizing low-cost equipment that is easy to install and certify for testing, advanced ATM ConOps can be validated, message content standards can be solidified, and new standards can be established through full-scale flight trials without necessary or expensive equipage or extensive flight test preparation. This paper presents results of a feasibility study of the NATIVE concept. To determine requirements, six NATIVE design configurations were developed for two NASA ConOps that rely on ADS-B. The performance characteristics of three existing in-flight Internet services were investigated to determine whether performance is adequate to support the concept. Next, a study of requisite hardware and software was conducted to examine whether and how the NATIVE concept might be realized. Finally, to determine a business case

  17. International VLBI Service for Geodesy and Astrometry 2007 Annual Report

    Science.gov (United States)

    Behrend, D. (Editor); Baver, K. D. (Editor)

    2008-01-01

    This volume of reports is the 2007 Annual Report of the International VLBI Service for Geodesy and Astrometry (IVS). The individual reports were contributed by VLBI groups in the international geodetic and astrometric community who constitute the components of IVS. The 2007 Annual Report documents the work of these IVS components over the period January 1, 2007 through December 31, 2007. The reports document changes, activities, and progress of the IVS. The entire contents of this Annual Report also appear on the IVS Web site at http://ivscc.gsfc.nasa.gov/publications/ar2007.

  18. International VLBI Service for Geodesy and Astrometry 2008 Annual Report

    Science.gov (United States)

    Behrend, Dirk; Baver, Karen D.

    2009-01-01

    This volume of reports is the 2008 Annual Report of the International VLBI Service for Geodesy and Astrometry (IVS). The individual reports were contributed by VLBI groups in the international geodetic and astrometric community who constitute the components of IVS. The 2008 Annual Report documents the work of these IVS components over the period January 1, 2008 through December 31, 2008. The reports document changes, activities, and progress of the IVS. The entire contents of this Annual Report also appear on the IVS Web site at http://ivscc.gsfc.nasa.gov/publications/ar2008.

  19. International VLBI Service for Geodesy and Astrometry 2011 Annual Report

    Science.gov (United States)

    Baver, Karen D. (Editor); Behrend, Dirk

    2012-01-01

    This volume of reports is the 2011 Annual Report of the International VLBI Service for Geodesy and Astrometry (IVS). The individual reports were contributed by VLBI groups in the international geodetic and astrometric community who constitute the components of IVS. The 2011 Annual Report documents the work of these IVS components over the period January 1, 2011 through December 31, 2011. The reports document changes, activities, and progress of the IVS. The entire contents of this Annual Report also appear on the IVS Web site at http://ivscc.gsfc.nasa.gov/publications/ar2011.

  20. International VLBI Service for Geodesy and Astrometry 2005 Annual Report

    Science.gov (United States)

    Behrend, Dirk (Editor); Baver, Karen D. (Editor)

    2006-01-01

    This volume of reports is the 2005 Annual Report of the International VLBI Service for Geodesy and Astrometry (IVS). The individual reports were contributed by VLBI groups in the international geodetic and astrometric community who constitute the components of IVS. The 2005 Annual Report documents the work of these IVS components over the period January 1, 2005 through December 31, 2005. The reports document changes, activities, and progress of the IVS. The entire contents of this Annual Report also appear on the IVS Web site at http://ivscc.gsfc.nasa.gov/publications/ar2005.

  1. Identification of novel dipeptidyl peptidase IV (DPP-IV) inhibitory peptides in camel milk protein hydrolysates.

    Science.gov (United States)

    Nongonierma, Alice B; Paolella, Sara; Mudgil, Priti; Maqsood, Sajid; FitzGerald, Richard J

    2018-04-01

    Nine novel dipeptidyl peptidase IV (DPP-IV) inhibitory peptides (FLQY, FQLGASPY, ILDKEGIDY, ILELA, LLQLEAIR, LPVP, LQALHQGQIV, MPVQA and SPVVPF) were identified in camel milk proteins hydrolysed with trypsin. This was achieved using a sequential approach combining liquid chromatography tandem mass spectrometry (LC-MS/MS), qualitative/quantitative structure activity relationship (QSAR) and confirmatory studies with synthetic peptides. The most potent camel milk protein-derived DPP-IV inhibitory peptides, LPVP and MPVQA, had DPP-IV half maximal inhibitory concentrations (IC 50 ) of 87.0 ± 3.2 and 93.3 ± 8.0 µM, respectively. DPP-IV inhibitory peptide sequences identified within camel and bovine milk protein hydrolysates generated under the same hydrolysis conditions differ. This was linked to differences in enzyme selectivity for peptide bond cleavage of camel and bovine milk proteins as well as dissimilarities in their amino acid sequences. Camel milk proteins contain novel DPP-IV inhibitory peptides which may play a role in the regulation of glycaemia in humans. Copyright © 2017 Elsevier Ltd. All rights reserved.

  2. Divergência genética em linhagens de melancia Genetic divergence in watermelon lines

    Directory of Open Access Journals (Sweden)

    Flávio de França Souza

    2005-06-01

    Full Text Available A divergência genética entre 31 genótipos de melancia foi avaliada por meio da análise de variáveis canônicas e de técnicas de agrupamento (Tocher e método hierárquico de Ward baseadas na distância generalizada de Mahalanobis (D²ii'. Trinta linhagens, obtidas a partir de acessos coletados no Nordeste brasileiro e a cultivar 'Crimson Sweet' foram avaliadas quanto ao número de dias para o aparecimento da primeira flor masculina e da primeira flor feminina (NDM e NDF; número do nó da primeira flor masculina e da primeira flor feminina (NGM e NGF; número de frutos por planta (NFP; comprimento de rama principal (CRP; peso médio de fruto (PMF; teor de sólidos solúveis (TSS; diâmetro transversal e longitudinal do fruto (DTF e DLF e espessura média de casca (EMC. O experimento foi realizado em delineamento de blocos ao acaso com três repetições, compostas por parcelas de sete plantas. As características que mais contribuíram para a divergência entre as linhagens foram número de frutos por planta, diâmetro longitudinal, teor de sólidos solúveis e peso médio de fruto. Foram formados três grupos por meio do método de otimização de Tocher, três por meio do método hierárquico de Ward e quatro grupos pela dispersão gráfica baseada nas duas primeiras variáveis canônicas. Neste caso, o grupo I compôs-se de sete linhagens de Pernambuco e uma da Bahia; o grupo II reuniu todas as 21 linhagens do Maranhão; os grupos III e IV foram compostos pela linhagem 97-0247.008 (Pernambuco e pela cultivar Crimson Sweet, respectivamente. As linhagens 87-019.021 e 87-019.022 foram as mais semelhantes, enquanto a linhagem 87-019.023 e 'Crimson Sweet' apresentaram maior dissimilaridade pela distância generalizada Mahalanobis (D²ii'. Os cruzamentos mais promissores serão aqueles realizados entre Crimson Sweet e as linhagens do grupo II. Cruzamentos entre Crimson Sweet e as linhagens do grupo I serão interessantes para a obtenção de

  3. DSM-IV hypochondriasis in primary care.

    Science.gov (United States)

    Escobar, J I; Gara, M; Waitzkin, H; Silver, R C; Holman, A; Compton, W

    1998-05-01

    The object of this study was to assess the prevalence and correlates of the DSM-IV diagnosis of hypochondriasis in a primary care setting. A large sample (N = 1456) of primary care users was given a structured interview to make diagnoses of mood, anxiety, and somatoform disorders and estimate levels of disability. The prevalence of hypochondriasis (DSM-IV) was about 3%. Patients with this disorder had higher levels of medically unexplained symptoms (abridged somatization) and were more impaired in their physical functioning than patients without the disorder. Of the various psychopathologies examined, major depressive syndromes were the most frequent among patients with hypochondriasis. Interestingly, unlike somatization disorder, hypochondriasis was not related to any demographic factor. Hypochondriasis is a relatively rare condition in primary care that is largely separable from somatization disorder but seems closely intertwined with the more severe depressive syndromes.

  4. Generation IV nuclear plant design strategies

    International Nuclear Information System (INIS)

    Altin, V.

    2007-01-01

    In this presentation Generation IV nuclear reactor design criteria are examined under the light of known nuclear properties of fissile and fertile nuclei. Their conflicting nature is elucidated along with the resulting inevitability of a multitude of designs. The designs selected as candidates for further development are evaluated with respect to their potential to serve the different design criteria, thereby revealing their more difficult aspects of realization and the strong research challenges lying ahead

  5. Genome Sequencing and Analysis Conference IV

    Energy Technology Data Exchange (ETDEWEB)

    1993-12-31

    J. Craig Venter and C. Thomas Caskey co-chaired Genome Sequencing and Analysis Conference IV held at Hilton Head, South Carolina from September 26--30, 1992. Venter opened the conference by noting that approximately 400 researchers from 16 nations were present four times as many participants as at Genome Sequencing Conference I in 1989. Venter also introduced the Data Fair, a new component of the conference allowing exchange and on-site computer analysis of unpublished sequence data.

  6. United Arab Emirates; 2013 Article IV Consultation

    OpenAIRE

    International Monetary Fund

    2013-01-01

    This staff report on United Arab Emirates 2013 Article IV Consultation highlights economic policies and development. Against a backdrop of political stability, confidence has further increased, tourism has been firm, demand from expatriates from the broader region has increased, and capital inflows have strengthened amid high global liquidity. The real estate sector, which had been impaired since the 2009 crisis, has stabilized in Abu Dhabi and has started to recover in Dubai. Dubai aims to b...

  7. Dipyridinium tribromidochloridobis(4-chlorophenylstannate(IV

    Directory of Open Access Journals (Sweden)

    Kong Mun Lo

    2009-06-01

    Full Text Available The tin atom in the substituted ammonium stannate(IV, (C5H6N2[SnBr3(C6H4Cl2Cl], lies on a center of symmetry in a distorted octahedral coordination geometry. Each independent halogen site is occupied by bromine and chlorine anions in an approximate 3:1 ratio. The pyridinium cation forms a hydrogen bond to only one of the halogen atoms.

  8. Structure of tetrakis(salicylaldehydato)thorium(IV)

    Energy Technology Data Exchange (ETDEWEB)

    Hill, R J; Rickard, C E.F. [Auckland Univ. (New Zealand). Dept. of Chemistry

    1977-01-01

    The structure of tetrakis(salicylaldehydato)thorium(IV) has been determined by single crystal X-ray crystallography. The crystals are tetragonal, a = 10.214, b = 23.744 A, space group P4/sub 1/. The molecules are eight coordinate, the coordination polyhedron being a dodecahedron with approximate Dsub(2d) symmetry. The dodecahedral A sites are occupied by the aldehydic oxygens and the phenolic oxygens occupy the B sites.

  9. Sandia Pulse Reactor-IV Project

    International Nuclear Information System (INIS)

    Reuscher, J.A.

    1983-01-01

    Sandia National Laboratories has developed, designed and operated fast burst reactors for over 20 years. These reactors have been used for a variety of radiation effects programs. During this period, programs have required larger irradiation volumes primarily to expose complex electronic systems to postulated threat environments. As experiment volumes increased, a new reactor was built so that these components could be tested. The Sandia Pulse Reactor-IV is a logical evolution of the two decades of fast burst reactor development at Sandia

  10. Plutonium(IV) hydrous polymer chemistry

    International Nuclear Information System (INIS)

    Toth, L.M.; Dodson, K.E.

    1985-01-01

    The hydrous polymer chemistry of Pu(IV) in aqueous nitric acid solutions has been a subject of considerable interest for several years. This interest stems mainly from the fact that most nuclear fuel reprocessing schemes based on the Purex process can be hampered by the occurrence of polymer. As a result, an understanding and control of the parameters that affect polymer formation during reprocessing are studied. 2 refs

  11. Biometria e armazenamento de sementes de genótipos de cacaueiro

    Directory of Open Access Journals (Sweden)

    Lucimara Ribeiro Venial

    2017-03-01

    Full Text Available Genótipos de Theobroma cacao L. devem ser melhor estudados, para se identificar aqueles que produzem sementes mais desenvolvidas e viáveis após o armazenamento. Objetivou-se com este trabalho estudar a biometria e dois tempos de armazenamento de sementes de genótipos de cacaueiro. A biometria foi avaliada em oito genótipos de cacaueiro (tratamentos. Foram instalados testes de germinação em delineamento inteiramente ao acaso, no esquema fatorial 8 x 2 (genótipos: CCN51, PH16, CEPEC2002, Ipiranga, SJ02, PS1319, TSH1188 e Comum x dois períodos de armazenamento: 0 e dois dias. O genótipo TSH1188 apresentou maior comprimento, relação comprimento/largura, espessura e massa de 100 sementes. A absorção de água das sementes recém-colhidas dos genótipos é lenta, justificada pelos altos teores de água, o que não caracteriza padrão-trifásico. Os teores de água reduziram em média 2,3 vezes nas sementes armazenadas em relação às recém-colhidas. A germinação das sementes recém-colhidas dos genótipos foi de 100%. Após o armazenamento, as sementes do PS1319 apresentaram a menor redução da germinação (39%, enquanto as dos PH16, CEPEC2002 e SJ02 reduziram 96%. A velocidade de germinação foi maior e o tempo médio menor que dois dias nas sementes recém-colhidas do PS1319, indicando serem mais tolerante à dessecação. Sugere-se o uso dos genótipos TSH1188 e PS1319 em programas de melhoramento genético.

  12. Ionizing radiation risk assessment, BEIR IV

    International Nuclear Information System (INIS)

    1991-10-01

    This report of the Subpanel discusses the potential impact on Federal agencies and indicates individual risk factors that could be used by them in risk assessment. The approach used in this CIRRPC report was to consider the risk factors presented in BEIR IV for each radionuclide (or group radioelements) and to make some judgments regarding their validity and/or the uncertainties involved. The coverage of Radon-222 and its progeny dominated the BEIR IV report and this Subpanel felt is was proper to devote more attention to this radionuclide family. This risk factor presented in BEIR IV for radon is 350 cancer deaths per million person-working level months (WLM) of exposure for a lifetime. There is a range of opinions on the conversion from WLM to absorbed dose. As discussed in the text, the use of the WLM concept makes it difficult or infeasible to compare the risk factor for radon with that of other radionuclides which are based on organ dose. This report also includes a discussion of certain fundamental scientific and operational issues that may have decisive effect upon risk factor selection. These adjunct items are dealt with under separate headings and include discussions of threshold dose considerations, extrapolation to low doses, and age at exposure

  13. TimeSet: A computer program that accesses five atomic time services on two continents

    Science.gov (United States)

    Petrakis, P. L.

    1993-01-01

    TimeSet is a shareware program for accessing digital time services by telephone. At its initial release, it was capable of capturing time signals only from the U.S. Naval Observatory to set a computer's clock. Later the ability to synchronize with the National Institute of Standards and Technology was added. Now, in Version 7.10, TimeSet is able to access three additional telephone time services in Europe - in Sweden, Austria, and Italy - making a total of five official services addressable by the program. A companion program, TimeGen, allows yet another source of telephone time data strings for callers equipped with TimeSet version 7.10. TimeGen synthesizes UTC time data strings in the Naval Observatory's format from an accurately set and maintained DOS computer clock, and transmits them to callers. This allows an unlimited number of 'freelance' time generating stations to be created. Timesetting from TimeGen is made feasible by the advent of Becker's RighTime, a shareware program that learns the drift characteristics of a computer's clock and continuously applies a correction to keep it accurate, and also brings .01 second resolution to the DOS clock. With clock regulation by RighTime and periodic update calls by the TimeGen station to an official time source via TimeSet, TimeGen offers the same degree of accuracy within the resolution of the computer clock as any official atomic time source.

  14. GenMAPP 2: new features and resources for pathway analysis

    Directory of Open Access Journals (Sweden)

    Dahlquist Kam D

    2007-06-01

    Full Text Available Abstract Background Microarray technologies have evolved rapidly, enabling biologists to quantify genome-wide levels of gene expression, alternative splicing, and sequence variations for a variety of species. Analyzing and displaying these data present a significant challenge. Pathway-based approaches for analyzing microarray data have proven useful for presenting data and for generating testable hypotheses. Results To address the growing needs of the microarray community we have released version 2 of Gene Map Annotator and Pathway Profiler (GenMAPP, a new GenMAPP database schema, and integrated resources for pathway analysis. We have redesigned the GenMAPP database to support multiple gene annotations and species as well as custom species database creation for a potentially unlimited number of species. We have expanded our pathway resources by utilizing homology information to translate pathway content between species and extending existing pathways with data derived from conserved protein interactions and coexpression. We have implemented a new mode of data visualization to support analysis of complex data, including time-course, single nucleotide polymorphism (SNP, and splicing. GenMAPP version 2 also offers innovative ways to display and share data by incorporating HTML export of analyses for entire sets of pathways as organized web pages. Conclusion GenMAPP version 2 provides a means to rapidly interrogate complex experimental data for pathway-level changes in a diverse range of organisms.

  15. Manipulación genética de seres humanos

    Directory of Open Access Journals (Sweden)

    Manuel Santos Alcántara

    2006-08-01

    Full Text Available El gran avance que ha tenido la Genética en los últimos años y, particularmente, aquello relacionado con el desciframiento del genoma humano, ha traído a la discusión pública la posibilidad concreta de manipular genéticamente a los seres humanos. El mejoramiento o perfeccionamiento genético de los seres humanos, denominado eugenesia, actualmente se ha convertido técnicamente en una realidad, motivando una profunda reflexión de tipo ético. La pregunta básica es la siguiente: aquello que es técnicamente posible de realizar ¿es ético hacerlo? ¿Tienen derecho los padres a acceder a la tecnología genética para mejorar las características de sus hijos? En este artículo se revisan las bases científicas del mejoramiento genético de los seres humanos, y se plantean los cuestionamientos éticos más relevantes derivados de esta manipulación.

  16. Contribuciones de Sir Roland Fisher a la Estadística Genética

    Directory of Open Access Journals (Sweden)

    Jaime Cuadros

    2004-11-01

    Full Text Available Sir Ronald Fisher (18901962 fue profesor de genética y muchas de sus innovaciones estadísticas encontraron expresión en el desarrollo de metodología en estadística genética. Sin embargo, mientras sus contribuciones en estadística matemática son fácilmente identificadas, en genética de poblaciones compartió su supremacía con Sewall Wright (1889 1988 y J. S. S. Haldane (1892 1965. Este documento muestra algunas de las mejores contribuciones de Fisher a las bases de la estadística genética, y sus interacciones con Wright y Haldane, los cuales contribuyeron al desarrollo del tema. Con la tecnología moderna, tanto la metodología la estadística como la información genética están cambiando. No obstante, muchos de los trabajos de Fisher permanecen relevantes, y pueden aun servir como una base para investigaciones futuras en el análisis estadístico de datos de DNA. El trabajo de este autor refleja su visión del papel de Ia estadística en Ia inferencia científica expresada en 1949

  17. Divergencia genética en poblaciones peruanas detectada a partir de las frecuencias haplotípicas del mtDNA y del gen nuclear MBL

    Directory of Open Access Journals (Sweden)

    Jesús H. Córdova

    2011-01-01

    Full Text Available Objetivos: Avanzar en el conocimiento del origen de las poblaciones peruanas estudiadas en un contexto filogeográfico. Diseño: Estudio genético poblacional. Instituciones: Laboratorio de Genética Humana, Facultad de Ciencias Biológicas, Universidad Nacional Mayor de San Marcos, e Instituto de Genética y Biología Molecular, Facultad de Medicina, Universidad San Martín de Porras, Lima, Perú. Participantes: Siete poblaciones peruanas. Metodología: Análisis comparativo de los resultados a partir del estudio del mtDNA y el gen nuclear MBL de siete poblaciones peruanas, procesados de manera separada y luego combinados, utilizando el programa PHYLYP 3.65, para obtener valores FST de diferenciación genética y la construcción de árboles de distancias por aplicación del algorritmo UPGMA y el análisis subsecuente de los agrupamientos (clusters generados. Principales medidas de resultados: Árboles genéticos generados. Resultados: De manera separada, los árboles generados para cada marcador genético tuvieron topologías propias y diferentes entre sí. Procesados de manera combinada, el árbol resultante demostró que los mayores valores de diferenciación genética se hallaron en las Islas del Lago Titicaca (Puno, Perú conocidas -Taquile, Amantani y Anapia-, que fue calificada como muy alta, porque mostró valores de FST de 0.3113, 0.2949 y 0.3348 respecto de las poblaciones estudiadas, tanto fuera del Departamento de Puno -como Chachapoyas, Pucallpa y Chiclayo, respectivamente-, así como a la de los Uro del mismo Puno y del mismo Lago Titicaca (0.2837. Fuera de Puno, el par de poblaciones Chachapoyas-Pucallpa fue el menos divergente, al alcanzar entre ellas un valor de FST de 0.0108, calificándosele de pequeña. Conclusiones: El árbol obtenido del procesamiento de los marcadores vía una matriz combinada demostró que las poblaciones que habitan las islas de Taquile, Amantani y Anapia, divergen notablemente de las restantes cuatro

  18. Estudio molecular del gen MLL en 30 pacientes con leucemias agudas Molecular study of MLL gen in 30 patients with acute leukemias

    Directory of Open Access Journals (Sweden)

    Raquel Levón Herrera

    2000-04-01

    Full Text Available Los reordenamientos del gen MLL en la banda cromosómica 11q23 son frecuentes en leucemias agudas (LA en niños y en las LA secundarias desarrolladas después de la terapia con inhibidores de la enzima topoisomerasa II. En menor medida también se aprecia en adultos con LA. La presencia de estos reordenamientos se considera un indicador de mal pronóstico asociado con resultados clínicos desfavorables, por ello es muy importante realizar su determinación en las LA. En este trabajo mostramos los resultados preliminares de la introducción del estudio del gen MLL en nuestro país mediante la técnica de Southern. Analizamos ADN de 30 pacientes con LA, incluidos niños y adultos, que en el momento del estudio se encontraban al debut o en recaída. El estudio molecular se realizó con la sonda FA4, que es un inserto genómico del gen MLL. Sólo uno de los 30 pacientes mostró bandas de reordenamiento con 2 enzimas de restricción diferentes, el resto mostró el gen MLL en configuración germinal. Es interesante destacar que el paciente con el reordenamiento era un niño con leucemia mieloblástica aguda subtipo M5b, lo cual concuerda con la literatura, donde se describe que estos reordenamientos están estrechamente correlacionados con los subtipos mielomonocítico (M4 y monocítico (M5 de leucemia mieloide aguda (LMARearrangements of MLL gen in llq23 chromosomal band are frequents in childhood type of acute leukemia (AL and in secondary AL, developed after therapy with II topoisomerase enzyme. To a lesser extent also is seen in adults with AL. Presence of theses rearrangements is considered to be a worse prognosis indicator, associated with unfavourable clinical results, that is why it is very important to carry our its assessment in AL. In this paper authors present preliminary results from introduction of study on MLL gen in our country through Southern technique. DNA from 30 patients was analized, including children and adults, that at the

  19. 76 FR 38709 - Excepted Service

    Science.gov (United States)

    2011-07-01

    ... for External Affairs and Environmental Education. Federal Communications Office of Media... Director of Public DH110070 4/4/2011 Services. Assistant Secretary Affairs. for Children and Families.... Administrator for Region Iv. Office of the Senior Policy Advisor SB110023 4/11/2011 Administrator. Social...

  20. Revised and extended analysis of Br IV

    International Nuclear Information System (INIS)

    Riyaz, A.; Rahimullah, K.; Tauheed, A.

    2014-01-01

    The spectrum of three-times ionized bromine Br IV has been studied in the 319–2350 Å wavelength region. The spectrum was recorded on a 3-m normal incidence vacuum spectrograph at the St. Francis Xavier University, Antigonish (Canada) and 6.65-m grazing incidence spectrograph at the Zeeman laboratory (Amsterdam). The light sources used were a triggered spark and sliding spark, respectively. The ground configuration of Br IV 3d 10 4s 2 4p 2 , the excited configurations 3d 10 4s4p 3 +3d 10 4s 2 4p (4d+5d+6d+5s+6s+7s) in the odd parity system and 3d 10 4s 2 4p (5p+4f+5f)+3d 10 4s4p 2 (4d+5s)+3d 10 4p 4 in the even parity system have been studied. Relativistic Hartree–Fock (HFR) and least squares fitted (LSF) parametric calculations were used to interpret the observed spectrum. 120 Levels of Br IV have now been established, 58 being new. Among 424 spectral lines, 277 are newly classified. The levels 4s4p 35 S 2 , 4s 2 4p4d 3 F 4 and 4p5p ( 3 P 0,1 , 3 D 1,2 , 3 S 1 ) are revised. We estimate the accuracy of our measured wavelength for sharp and unblended lines to be ±0.005 Å. The ionization limit is determined as 385,390±100 cm −1 (47.782±0.012 eV). -- Highlights: • The spectrum of Br was recorded on a 3-m spectrograph with triggered spark source. • Atomic transitions for Br IV were identified to established new energy levels. • CI calculations with relativistic corrections were made for theoretical predictions. • Weighted oscillator strength (gf) and transition probabilities (gA) were calculated. • Ionization potential of Br IV was determined experimentally

  1. Jurados ciudadanos y organismos genéticamente modificados

    Directory of Open Access Journals (Sweden)

    Luque, Emilio

    2005-04-01

    Full Text Available Apolitical sociology of food must look into the processes whereby regulatory decisions on food are made, and also into the democratic potential of their alternatives. Five "experiments in democracy" are described, in which a promising deliberative device has been used: citizens' juries. Indian and Brazilian peasants, on the one hand, and British consumers in the other took part in them, and they focused on Genetically Modified Organisms. These processes, whose defining trait is granting jurors access to expert witnesses presented by all stakeholders in the controversy, show the impressive ability of ordinary citizens to articulate their analysis of complex issues, a reassessment of risks, and a recontextualization of the use of GMOs. At any rate, deliberative democracy is not a magic bullet for the epistemic and political crisis that underlies food crisis; instead, it points at a paradigm change towards an experimental democratic polity in which the instances of representation of the public and publics are multiplied.

    Una sociología política de la alimentación debe analizar los procesos a través de los cuales se alcanzan las decisiones de regulación y control alimentario y examinar el potencial de sus alternativas. Se describen aquí cinco experimentos democráticos en los que se ha empleado uno de los dispositivos deliberativos más prometedores en condiciones de alta complejidad cognitiva, los llamados jurados ciudadanos, con la participación de campesinos hindúes y brasileños y consumidores británicos, y centrados en los Organismos Genéticamente Modificados. Estos procesos, caracterizados por el acceso de los miembros del jurado a testigos expertos presentados por los distintos participantes en la controversia, muestran la enorme capacidad de los ciudadanos "de a pie" para articular el análisis de un problema complejo, reevaluar sus riesgos y recontextualizar el uso de los OGM. En todo caso, la democracia deliberativa no es

  2. An External Independent Validation of APACHE IV in a Malaysian Intensive Care Unit.

    Science.gov (United States)

    Wong, Rowena S Y; Ismail, Noor Azina; Tan, Cheng Cheng

    2015-04-01

    Intensive care unit (ICU) prognostic models are predominantly used in more developed nations such as the United States, Europe and Australia. These are not that popular in Southeast Asian countries due to costs and technology considerations. The purpose of this study is to evaluate the suitability of the acute physiology and chronic health evaluation (APACHE) IV model in a single centre Malaysian ICU. A prospective study was conducted at the single centre ICU in Hospital Sultanah Aminah (HSA) Malaysia. External validation of APACHE IV involved a cohort of 916 patients who were admitted in 2009. Model performance was assessed through its calibration and discrimination abilities. A first-level customisation using logistic regression approach was also applied to improve model calibration. APACHE IV exhibited good discrimination, with an area under receiver operating characteristic (ROC) curve of 0.78. However, the model's overall fit was observed to be poor, as indicated by the Hosmer-Lemeshow goodness-of-fit test (Ĉ = 113, P discrimination was not affected. APACHE IV is not suitable for application in HSA ICU, without further customisation. The model's lack of fit in the Malaysian study is attributed to differences in the baseline characteristics between HSA ICU and APACHE IV datasets. Other possible factors could be due to differences in clinical practice, quality and services of health care systems between Malaysia and the United States.

  3. Tools for Designing, Evaluating, and Certifying NextGen Technologies and Procedures: Automation Roles and Responsibilities

    Science.gov (United States)

    Kanki, Barbara G.

    2011-01-01

    Barbara Kanki from NASA Ames Research Center will discuss research that focuses on the collaborations between pilots, air traffic controllers and dispatchers that will change in NextGen systems as automation increases and roles and responsibilities change. The approach taken by this NASA Ames team is to build a collaborative systems assessment template (CSAT) based on detailed task descriptions within each system to establish a baseline of the current operations. The collaborative content and context are delineated through the review of regulatory and advisory materials, policies, procedures and documented practices as augmented by field observations and interviews. The CSAT is developed to aid the assessment of key human factors and performance tradeoffs that result from considering different collaborative arrangements under NextGen system changes. In theory, the CSAT product may be applied to any NextGen application (such as Trajectory Based Operations) with specified ground and aircraft capabilities.

  4. International VLBI Service for Geodesy and Astrometry 2000 Annual Report

    Science.gov (United States)

    Vandenberg, N. R. (Editor); Baver, K. D. (Editor); Smith, David E. (Technical Monitor)

    2000-01-01

    This volume of reports is the 2000 Annual Report of the International Very Long Base Interferometry (VLBI) Service for Geodesy and Astrometry (IVS). The individual reports were contributed by VLBI groups in the international geodetic and astrometric community who constitute the permanent components of IVS. The IVS 2000 Annual Report documents the work of the IVS components for the period March 1, 1999 (the official inauguration date of IVS) through December 31, 2000. The reports document changes, activities, and progress of the IVS. The entire contents of this Annual Report also appear on the IVS web site at http://ivscc.gsfc.nasa.gov/publications/ar2000. This book and the web site are organized as follows: (1) The first section contains general information about IVS, a map showing the location of the components, information about the Directing Board members, and the report of the IVS Chair; (2) The second section of Special Reports contains a status report of the IVS Working Group on GPS phase center mapping, a reproduction of the resolution making IVS a Service of the International Astronomical Union (IAU), and a reprint of the VLBI Standard Interface (VSI); (3) The next seven sections hold the component reports from the Coordinators, Network Stations, Operation Centers, Correlators, Data Centers, Analysis Centers, and Technology Development Centers; and (4) The last section includes reference information about IVS: the Terms of Reference, the lists of Member and Affiliated organizations, the IVS Associate Member list, a complete list of IVS components, the list of institutions contributing to this report, and a list of acronyms. The 2000 Annual Report demonstrates the vitality of the IVS and the outstanding progress we have made during our first 22 months.

  5. Synthesis and evaluation of artificial antigens for astragaloside IV

    Directory of Open Access Journals (Sweden)

    Sheng-lan Yu

    Full Text Available The objective of this study was to produce artificial antigens for astragaloside IV that could be used to prepare antibodies against astragaloside IV screened in Radix astragali (Astragalus membranaceus (Fisch Bunge, Fabaceae and its preparations, using an indirect ELISA. Astragaloside IV was coupled to carrier proteins, bovine serum albumin and ovalbumin using the sodium periodate method and was then evaluated using SDS-PAGE, MALDI-TOF MS and animal immunizations. The coupling ratio of astragaloside IV to bovine serum albumin ratio was determined to be thirteen, and the indirect ELISA demonstrated that three groups of mice immunized with astragaloside IV-bovine serum albumin produced anti-astragaloside IV- bovine serum albumin-specific antibody, with a minimum serum titer of 1:9600. A method for synthesizing highly immunogenic astragaloside IV artificial antigens was successfully developed thus indicating its feasibility in the establishment of a fast immunoassay for astragaloside IV content determination in Radix astragali and its products.

  6. A Si IV/O IV Electron Density Diagnostic for the Analysis of IRIS Solar Spectra

    Science.gov (United States)

    Young, P. R.; Keenan, F. P.; Milligan, R. O.; Peter, H.

    2018-04-01

    Solar spectra of ultraviolet bursts and flare ribbons from the Interface Region Imaging Spectrograph (IRIS) have suggested high electron densities of > {10}12 cm‑3 at transition region temperatures of 0.1 MK, based on large intensity ratios of Si IV λ1402.77 to O IV λ1401.16. In this work, a rare observation of the weak O IV λ1343.51 line is reported from an X-class flare that peaked at 21:41 UT on 2014 October 24. This line is used to develop a theoretical prediction of the Si IV λ1402.77 to O IV λ1401.16 ratio as a function of density that is recommended to be used in the high-density regime. The method makes use of new pressure-dependent ionization fractions that take account of the suppression of dielectronic recombination at high densities. It is applied to two sequences of flare kernel observations from the October 24 flare. The first shows densities that vary between 3× {10}12 and 3× {10}13 cm‑3 over a seven-minute period, while the second location shows stable density values of around 2× {10}12 cm‑3 over a three-minute period.

  7. O futuro da epidemiologia genética de características complexas

    Directory of Open Access Journals (Sweden)

    Feitosa Mary F.

    2002-01-01

    Full Text Available A epidemiologia genética evoluiu de um enfoque em estudos sobre doenças mendelianas raras para a análise genética de características complexas. Com o advento de informações sobre a completa seqüência de genes ao longo do genoma humano e de outros organismos, o interesse da epidemiologia genética em desvendar a natureza dos fatores que influenciam essas características se tornou primordial. São apresentados os principais métodos empregados no estudo de doenças complexas bem como suas principais vantagens e desvantagens. Discute-se a importância na determinação da amostra e o uso de fenótipos e marcadores genéticos apropriados. Como exemplo das estratégias citadas tomamos o estudo de índice de massa corporal (BMI para ilustrar um fator genético principal localizado no cromossomo 7. Em uma discussão sobre tendências no estudo de ligação, embora reconhecendo que famílias e genealogias continuarão sendo o foco principal das amostras, discute-se alguns novos e eficientes tipos de amostragem (como por exemplo, controles não-relacionados em que amostras de conjunto de DNA serão universalmente empregadas. O reconhecimento da heterogeneidade genética entre estudos e sua interpretação será uma das mais importantes características no futuro das análises de características complexas.

  8. Coeficiente de repetibilidade e parâmetros genéticos em capim-elefante

    Directory of Open Access Journals (Sweden)

    Marcelo Cavalcante

    2012-04-01

    Full Text Available O objetivo deste trabalho foi determinar os coeficientes de repetibilidade de caracteres morfofisiológicos em genótipos de capim-elefante (Pennisetum spp., a partir de dados obtidos durante seis ciclos de avaliação. Foram estimados: número mínimo de medições e parâmetros genéticos. Utilizou-se o delineamento experimental de blocos ao acaso, em arranjo de parcelas subdivididas, com quatro níveis de N (controle, 30, 60 e 90 kg ha‑1 por corte e 16 genótipos de Pennisetum (11 híbridos interespecíficos e cinco cultivares. Os ciclos consistiram de avaliações em 2010 (21/4, 19/7 e 28/9 e 2011 (6/1, 7/4 e 3/8. Os coeficientes de repetibilidade foram de média‑alta magnitude para todas as variáveis, o que indica que houve regularidade entre as medidas repetidas. Para as variáveis massa de forragem, altura da planta, comprimento e largura da folha, diâmetro do colmo, clorose e índice de área foliar, três ciclos de avaliação são suficientes para obter R² de 90%, pela análise de componentes principais. Para o comprimento do entrenó, o mínimo de sete avaliações é necessário para predizer o valor real dos genótipos. Os parâmetros genéticos das variáveis massa de forragem, comprimento e largura da folha, diâmetro do colmo e clorose foliar são de alta magnitude, o que favorece a seleção de genótipos superiores de Pennisetum.

  9. Loci asociados con enfermedades genéticas y calidad de carne en bovinos Charolais Mexicanos

    Directory of Open Access Journals (Sweden)

    Ana María Sifuentes Rincón

    2015-01-01

    Full Text Available Se determinaron las frecuencias alélicas y genotípicas de ocho marcadores localizados en los genes calpaína (CAPN, 4 751 y 316, calpastatina (CASTT1 y tiroglobulina (TG5, asociados a calidad de carne, y en los genes, m iost atina (MSTN, Q204X, arginino succinato sintasa (ASS, monofosfato sintasa (UMPS y miofosforilasa (PYGM, asocia dos a enfermedade s genéticas de ganado bovino. Se muestrearon 493 animales Charolais de registro de dos hatos ubicado s en Sonora (n=157 y tres en Nuevo León (n=336. No se encontraron portadores de los alelos T-ASS y T-UM PS, pero sí portadores del alelo Q204X del gen MSTN en frecuencias de  1 % en las poblaciones de Sonora y de 8.6 a 14.4 % en las de Nuevo León. Además, se identificaron portadores del marcador del gen PYGM, en frecuencias del 6.5 y de 1.0 % para un hato de Sonora y otro de Nuevo León, respectivamente. El análisis de diferenciación génica p areado entre las poblaciones y con los cuatro loci mostró que hay diferencias altamente significativas dentro de pobl aciones del noroeste ( P <0.0001 y entre éstas y las del noreste ( P <0.001, la cual es explicada principalmente por los loci CAPN-316 y TG5. De acuerdo a los resultados obtenidos se recomienda el monitoreo del marcador del gen PYGM y del ale lo Q204X del gen MSTN, así como también implementar estrategias para confirmar la utilidad de los marcadores asociado s a calidad y productividad como herramienta para complementar los progra mas de mejoramiento genético.

  10. SIPSMetGen: It's Not Just For Aircraft Data and ECS Anymore.

    Science.gov (United States)

    Schwab, M.

    2015-12-01

    The SIPSMetGen utility, developed for the NASA EOSDIS project, under the EED contract, simplified the creation of file level metadata for the ECS System. The utility has been enhanced for ease of use, efficiency, speed and increased flexibility. The SIPSMetGen utility was originally created as a means of generating file level spatial metadata for Operation IceBridge. The first version created only ODL metadata, specific for ingest into ECS. The core strength of the utility was, and continues to be, its ability to take complex shapes and patterns of data collection point clouds from aircraft flights and simplify them to a relatively simple concave hull geo-polygon. It has been found to be a useful and easy to use tool for creating file level metadata for many other missions, both aircraft and satellite. While the original version was useful it had its limitations. In 2014 Raytheon was tasked to make enhancements to SIPSMetGen, this resulted a new version of SIPSMetGen which can create ISO Compliant XML metadata; provides optimization and streamlining of the algorithm for creating the spatial metadata; a quicker runtime with more consistent results; a utility that can be configured to run multi-threaded on systems with multiple processors. The utility comes with a java based graphical user interface to aid in configuration and running of the utility. The enhanced SIPSMetGen allows more diverse data sets to be archived with file level metadata. The advantage of archiving data with file level metadata is that it makes it easier for data users, and scientists to find relevant data. File level metadata unlocks the power of existing archives and metadata repositories such as ECS and CMR and search and discovery utilities like Reverb and Earth Data Search. Current missions now using SIPSMetGen include: Aquarius, Measures, ARISE, and Nimbus.

  11. Collagen type IV at the fetal-maternal interface

    OpenAIRE

    Oefner, C M; Sharkey, A; Gardner, L; Critchley, H; Oyen, M; Moffett, A

    2015-01-01

    Introduction Extracellular matrix proteins play a crucial role in influencing the invasion of trophoblast cells. However the role of collagens and collagen type IV (col-IV) in particular at the implantation site is not clear. Methods Immunohistochemistry was used to determine the distribution of collagen types I, III, IV and VI in endometrium and decidua during the menstrual cycle and the first trimester of pregnancy. Expression of col-IV alpha chains during the reproductive cycle ...

  12. Alimentos Transgénicos : Organismos Genéticamente Modificados (OGM)

    OpenAIRE

    Martín López, Jimena

    2016-01-01

    Los alimentos transgénicos son aquellos que proceden de un organismo modificado genéticamente. La introducción de este tipo de productos en nuestra dieta es un tema que genera controversia ya que en muchos casos no se conoce con exactitud los efectos que esta modificación puede tener en el ser humano. A lo largo de las páginas de este trabajo se explica la historia de la aparición de estos organismos gracias a procedimientos de ingeniería genética, en los que se modifican fragmentos de su ADN...

  13. Prevalencia de bacterias Gram negativas portadoras del gen blaKPC en hospitales de Colombia

    Directory of Open Access Journals (Sweden)

    Robinson Pacheco

    2014-04-01

    Full Text Available Introducción. Las enzimas carbapenemasas de tipo KPC tienen gran capacidad de diseminación, son causantes de epidemias y se asocian a mayor mortalidad y estancia hospitalaria. En Colombia se han venido reportando cada vez más desde 2007, pero se desconoce la prevalencia hospitalaria. Objetivo. Estimar la prevalencia hospitalaria del gen blaKPC. Materiales y métodos. Se evaluó la presencia del gen blaKPC y su ‘clonalidad’ en aislamientos de enterobacterias y Pseudomonas aeruginosa de pacientes hospitalizados. Resultados. De los 424 aislamientos evaluados durante el periodo de estudio, 273 cumplieron con criterios de elegibilidad, 31,1 % fue positivo para el gen blaKPC y, al ajustar por ‘clonalidad’, la positividad fue de 12,8 %. El gen blaKPC se encontró con mayor frecuencia en Klebsiella pneumoniae seguido de P. aeruginosa y otras enterobacterias. A pesar de que la unidad de cuidados intensivos aportó el mayor número de aislamientos, no se encontró un patrón más prevalente del gen blaKPC en las ellas que en las otras salas. El aparato respiratorio fue el sitio anatómico de origen con la mayor prevalencia. No se presentó estacionalidad en la frecuencia de los aislamientos portadores del gen blaKPC. Conclusión. Este estudio reveló la alta prevalencia del gen blaKPC en diferentes microorganismos aislados en varias instituciones hospitalarias del país. La extraordinaria capacidad de propagación del gen blaKPC, las dificultades del diagnóstico y la limitada disponibilidad de antibióticos plantean la apremiante necesidad de fortalecer los sistemas de vigilancia epidemiológica y ajustar oportunamente las políticas institucionales de uso racional de antibióticos con el fin de contener su diseminación a otras instituciones de salud del país.

  14. Prevalencia de bacterias Gram negativas portadoras del gen blaKPC en hospitales de Colombia

    OpenAIRE

    Robinson Pacheco; Lyda Osorio; Adriana M. Correa; Maria Virginia Villegas

    2014-01-01

    Introducción. Las enzimas carbapenemasas de tipo KPC tienen gran capacidad de diseminación, son causantes de epidemias y se asocian a mayor mortalidad y estancia hospitalaria. En Colombia se han venido reportando cada vez más desde 2007, pero se desconoce la prevalencia hospitalaria. Objetivo. Estimar la prevalencia hospitalaria del gen blaKPC. Materiales y métodos. Se evaluó la presencia del gen blaKPC y su ‘clonalidad’ en aislamientos de enterobacterias y Pseudomonas aeruginosa de p...

  15. Microsatélites, distancias genéticas y estructura de poblaciones nativas sudamericanas

    Directory of Open Access Journals (Sweden)

    Demarchi, Darío Alfredo

    2009-01-01

    Full Text Available En este trabajo se investigaron las relaciones genéticas entre 17 poblaciones nativas sudamericanas en relación a 15 microsatélites (STRs autosómicos, utilizando 3 distancias genéticas- DST, DAy (δu2-que se ajustan a diferentes postulados teóricos. A través de diferentes técnicas de análisis (escalamiento multidimensional, correlación y correlación parcial de matrices se puso a prueba si las distancias genéticas reflejaban las relaciones interpoblacionales esperadas a partir de la distribución geográfica o de relaciones lingüísticas entre las poblaciones. Además, se estimó en que grado las distintas medidas de distancias genéticas eran influenciadas por la diversidad (He de cada población. Los mapas genéticos muestran, principalmente para DST y DA, que las poblaciones aisladas y con bajo tamaño efectivo (Ne aparecen como outliers, mientras que las poblaciones con alto Ne y mayor flujo génico ocupan una posición central a bajos valores de distancia unas de otras y sin un patrón definido de agrupamiento. La falta de asociación entre distancias genéticas y lingüísticas o geográficas y por otra parte, la alta correlación negativa entre He y distancias génicas promedio por población confiman ese patrón, demostrando que la mayor parte de la variación interpoblacional puede ser explicada en función del grado de diversidad intrapoblacional. Es decir, las distancias genéticas no reflejan relaciones filogenéticas, lingüísticas o geográficas, sino más bien eventos demográficos recientes tales como cuellos de botella genético, efecto fundador o migración externa masiva. Este hecho puede ser comprobado por medio de otra metodología analítica, el modelo de Harpending y Ward.

  16. Description of a new genus, Galgoria gen. nov. (Hemiptera: Cicadidae: Cicadinae: Leptopsaltriini: Leptopsaltriina).

    Science.gov (United States)

    Lee, Young June

    2016-05-10

    A new cicada genus, Galgoria gen. nov., is described with Tanna herzbergi Schmidt, 1932 (from southern China) as its type species, which is placed in the subtribe Leptopsaltriina Moulton, 1923 of the tribe Leptopsaltriini Moulton, 1923 in the subfamily Cicadinae Latreille, 1802 (Hemiptera: Cicadidae). Tanna herzbergi Schmidt, 1932 is transferred from Tanna Distant, 1905 to Galgoria gen. nov. to become Galgoria herzbergi (Schmidt, 1932) comb. nov. Tanna apicalis Chen, 1940 syn. nov. and Tanna pseudocalis Lei & Chou, 1997 syn. nov. are synonymized here with Galgoria herzbergi (Schmidt, 1932) comb. nov.

  17. LEPINOCONUS CHIOCCHINII GEN. N., N. SP., A CONICAL AGGLUTINATED FORAMINIFERA FROM THE UPPER CRETACEOUS OF ITALY

    Directory of Open Access Journals (Sweden)

    ERZIKA CRUZ-ABAD

    2017-04-01

    Full Text Available A new conical agglutinated foraminifer, Lepinoconus chiocchinii gen n., n. sp. from the lower Campanian shallow-water platform deposits of the Lepini Mountains (central Apennines, Italy, is described. It has a pseudo-keriothecal wall structure, uniserial arrangement of the adult chambers and multiple apertures. The exoskeleton is constituted by beams (main and intercalary continuous from one chamber to the next, while the endoskeleton bears pillars. The new taxon is included in the Coskinolinidae family. Lepinoconus chiocchinii gen. n., n. sp. is known from southern Italy, Greece and Albania.

  18. Reporte de familias con neurofibromatosis y otras enfermedades genéticas

    OpenAIRE

    Orraca Castillo, Miladys; Licourt Otero, Deysi; Sánchez Álvarez de La Campa, Ana Isabel

    2011-01-01

    La neurofibromatosis tipo 1, es una enfermedad genética que primariamente afecta el desarrollo y crecimiento celular del sistema nervioso, clínicamente se caracteriza por máculas café con leche, neurofibromas, pecas en regiones no expuestas al sol, nódulos de Lisch, lesiones óseas y glioma óptico. En el presente trabajo se describen dos familias, en las cuales algunos individuos padecen esta enfermedad y otros miembros de la misma familia muestran una diferente enfermedad genética. La coexist...

  19. InGen Inconsistencies: The "Dinosaurs" Of Jurassic Park May Not Be What The Corporation Claims

    Science.gov (United States)

    Haupt, R. J.; Traer, M. M.

    2017-12-01

    InGen has made and continues to make dubious claims about proprietary technology developed to clone non-avian dinosaurs for exhibition within their "Jurassic Park." Notably, there are several inconsistencies between their claims for how their technology works and what has been observed within the park. Here we investigate several of these inconsistencies in the hopes that it will push for increased transparency between corporations and academia. First, we highlight a disconnect between supposedly Jurassic amber used for dinosaur DNA extraction and the overwhelming presence of Late Cretaceous dinosaurs within the park. Further, InGen's mining operations only publicly operate in Jurassic-aged formations of the Dominican Republic, which clashes with the presence of Velociraptor and Gallimimus, known only from Mongolia. Second, the park contains seemingly full-grown adult specimens despite InGen's claims that they first successfully cloned a prehistoric animal in 1984, though there is no publicly available information as to what animal this was. That the park was nearly ready to open by 1993 precludes the presence of fully mature dinosaurs and suggests that InGen might be misrepresenting their technologies. Third, we must point out that fossil DNA denatures to the point of uselessness within thousands, not millions, of years. Additionally, the use of anuran DNA to fill in gaps from fossil dinosaurian DNA is a dubious choice given that more closely related organisms are available. Either there is an unexplained reason for this choice, or little attention has been paid to dinosaurian phylogeny by InGen geneticists. Finally, rumors of a secret InGen project to produce a dinosaur not currently known to paleontologists suggests one of two things: they were able to find DNA from a dinosaur previously unknown in the fossil record, which is highly plausible if their techniques are valid, or that InGen is able to artificially manipulate DNA to a degree far beyond what other

  20. Aspectos genéticos y neuroendocrinos en el trastorno del espectro autista

    OpenAIRE

    Oviedo, Norma; Manuel-Apolinar, Leticia; de la Chesnaye, Elsa; Guerra-Araiza, Christian

    2015-01-01

    El autismo, hoy en día definido como trastornos del espectro autista, fue descrito inicialmente en 1943. Se caracteriza por alteraciones en la comunicación, la interacción social y un espectro restringido de intereses del paciente. Generalmente se identifica en etapas tempranas del desarrollo a partir de los 18 meses de edad. Actualmente el autismo se considera un desorden neurológico con un espectro que abarca diferentes grados que se asocian con factores genéticos, no genéticos y del medio ...

  1. Melostelis gen. nov., espécies novas e notas complementares sobre Anthidiini (Hymenoptera, Apidae

    Directory of Open Access Journals (Sweden)

    Danúncia Urban

    2011-06-01

    Full Text Available Melostelis gen. nov., espécies novas e notas complementares sobre Anthidiini (Hymenoptera, Apidae. Melostelis gen. nov. é proposto para um novo Anthidiini cleptoparasita. São descritas e ilustradas duas espécies novas: Melostelis amazonensis sp. nov. de Manaus, Amazonas e Larocanthidium chacoense sp. nov. de Porto Murtinho, Mato Grosso do Sul. São dados a conhecer os machos de Epanthidium bolivianum Urban, 1995 e Epanthidium araranguense Urban, 2006 e, registrados pela primeira vez no Brasil, na sub-região do chaco, Ketianthidium zanolae Urban, 2000 e Epanthidium bolivianum.

  2. Clasificador genérico de objetos en imágenes AVHRR

    OpenAIRE

    Pascual Ramírez, Fermín; Paz Pellat, Fernando; Martínez Menes, Mario; Palacios Vélez, Enrique; Mejía Sáenz, Enrique; Rubio Granados, Erasmo

    2010-01-01

    El presente artículo describe un algoritmo para llevar a cabo una clasificación genérica de objetos utilizando imágenes del sensor advanced very high resolution radiometer (AVHRR), basado en la firma espectral de los objetos genéricos (suelo, mezcla suelo-vegetación, cuerpos de agua, nubes, etc.). Debido a las particularidades de las bandas disponibles en el sensor AVHRR, se presenta un algoritmo específico utilizando la banda 3a (B3a) y otro utilizando la banda 3b (B3b) de este sensor. Los a...

  3. Inventering av Suldalslågen. Produksjonspotensial for sjøvandrende laksefisk

    OpenAIRE

    Foldvik, Anders; Pettersen, Oskar

    2017-01-01

    Foldvik, A. & Pettersen, O. 2017. Inventering av Suldalslågen. Produksjonspotensial for sjøvandrende laksefisk. - NINA Kortrapport 75, 18 s. Reguleringen av Suldalslågen til kraftproduksjon har hatt negative effekter for habitat for laksefisk, blant annet i form av sedimentering og begroing av substratet. Disse prosessene har blitt forsøkt motvirket ved å ha en serie med spyleflommer på over 200 m3/s om høsten. På oppdrag fra Statkraft inverterte NINA oppvekst- og gyteforhold for laks i Su...

  4. História da genética no Brasil: um olhar a partir do Museu da Genética da Universidade Federal do Rio Grande do Sul

    Directory of Open Access Journals (Sweden)

    Vanderlei Sebastiao de Souza

    2013-06-01

    Full Text Available Aborda o contexto de criação do Museu da Genética, em 2011 no Departamento de Genética na Universidade Federal do Rio Grande do Sul, em Porto Alegre, e apresenta sua estrutura e conteúdo. Argumenta-se que os materiais disponibilizados no Museu da Genética constituem uma rica fonte para pesquisas sobre a história da genética no Brasil (e da genética de populações humanas em particular a partir da segunda metade do século XX, tema ainda pouco investigado, apesar da proeminência dessa área do conhecimento no Brasil.

  5. Reflexo da interação genótipo x ambiente sobre o melhoramento genético de feijão

    OpenAIRE

    Pereira, Thayse Cristine Vieira; Schmit, Rodolfo; Haveroth, Eduardo José; Melo, Rita Carolina de; Coimbra, Jefferson Luís Meirelles; Guidolin, Altamir Frederico; Backes, Rogério Luiz

    2015-01-01

    RESUMO: O objetivo foi avaliar os componentes da variância fenotípica e estimar a influência da interação genótipo*ambiente no rendimento de grãos em feijão. Os componentes da variância fenotípica foram estimados pelo método da máxima verossimilhança restrita e do melhor preditor linear não viesado (REML/BLUP), juntamente com o espaço de inferência específico. As avaliações foram realizadas nas safras agrícolas de 2006/07 a 2011/12 no município de Lages/SC. Durante o período, 104 genótipos fo...

  6. Dipeptidyl peptidase IV inhibitory activity of protein hydrolyzates ...

    African Journals Online (AJOL)

    Background: Type 2 diabetes is a chronic metabolic disorder. Recently, dipeptidyl peptidase IV (DPP-IV) inhibitors that protect incretin hormones from being cleaved by DPP-IV have been used as drugs to control glycemia. This study examined the potential hypoglycemic effect of amaranth grain storage protein hydrolyzates ...

  7. 77 FR 64398 - Order of Succession for HUD Region IV

    Science.gov (United States)

    2012-10-19

    ... Region IV AGENCY: Office of Field Policy and Management, HUD. ACTION: Notice of Order of Succession... Field Offices (Region IV). This Order of Succession supersedes all previous Orders of Succession for HUD Region IV. DATES: Effective Date: October 9, 2012. FOR FURTHER INFORMATION CONTACT: Lawrence D. Reynolds...

  8. Revised and extended analysis of Br IV

    Science.gov (United States)

    Riyaz, A.; Rahimullah, K.; Tauheed, A.

    2014-01-01

    The spectrum of three-times ionized bromine Br IV has been studied in the 319-2350 Å wavelength region. The spectrum was recorded on a 3-m normal incidence vacuum spectrograph at the St. Francis Xavier University, Antigonish (Canada) and 6.65-m grazing incidence spectrograph at the Zeeman laboratory (Amsterdam). The light sources used were a triggered spark and sliding spark, respectively. The ground configuration of Br IV 3d104s24p2, the excited configurations 3d104s4p3+3d104s24p (4d+5d+6d+5s+6s+7s) in the odd parity system and 3d104s24p (5p+4f+5f)+3d104s4p2 (4d+5s)+3d104p4 in the even parity system have been studied. Relativistic Hartree-Fock (HFR) and least squares fitted (LSF) parametric calculations were used to interpret the observed spectrum. 120 Levels of Br IV have now been established, 58 being new. Among 424 spectral lines, 277 are newly classified. The levels 4s4p35S2, 4s24p4d 3F4 and 4p5p (3P0, 1, 3D1, 2, 3S1) are revised. We estimate the accuracy of our measured wavelength for sharp and unblended lines to be ±0.005 Å. The ionization limit is determined as 385,390±100 cm-1 (47.782±0.012 eV).

  9. 20 CFR 638.523 - Food service.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Food service. 638.523 Section 638.523 Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION, DEPARTMENT OF LABOR JOB CORPS PROGRAM UNDER TITLE IV-B OF THE JOB TRAINING PARTNERSHIP ACT Center Operations § 638.523 Food service. (a) The center...

  10. Allocation of Laophonte trispinosa Sewell to Xanthilaophonte gen. nov. and the description of X. carcinicola spec. nov. (Harpacticoida: Laophontidae)

    NARCIS (Netherlands)

    Fiers, F.

    1991-01-01

    Laophonte trispinosa Sewell is reported here from various localities in the Indian and the West Pacific Ocean, and is allocated to the herein erected genus Xanthilaophonte gen. nov. A second species, X. carcinicola spec. nov. is described from Indon »sia. The genus Xanthilaophonte gen. nov. is most

  11. 75 FR 1052 - Terra-Gen Dixie Valley, LLC; TGP Dixie Development Company, LLC; New York Canyon, LLC; Notice of...

    Science.gov (United States)

    2010-01-08

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. EL10-29-000] Terra-Gen Dixie Valley, LLC; TGP Dixie Development Company, LLC; New York Canyon, LLC; Notice of Filing December 30, 2009. Take notice that on December 24, 2009, Terra-Gen Dixie Valley, LLC, TGP Dixie Development Company, LLC...

  12. Using the kaleidoscope career model to examine generational differences in work attitudes between Gen X and Gen Y– within Malaysia Perspective

    OpenAIRE

    Koay, Chee Hua Alwyn

    2016-01-01

    Generation Y (also known as Yers) has started to take a prominent position in today’s workforce. With this new position comes a new territory of research. The research about this generation has increased over the past years, with most of this research focusing on characteristics of GenY (Sheahan (2005), Martin (2005), Armour (2005)) and the differences between generations (Smola and Sutton (2002), Cennamo and Gardner (2008)). Noticeably, there has been many literature and news (Hoi J., 2013) ...

  13. Synthesis and characterization of thorium(IV) and uranium(IV) complexes with Schiff bases

    Energy Technology Data Exchange (ETDEWEB)

    Radoske, Thomas; Maerz, Juliane; Kaden, Peter; Patzschke, Michael; Ikeda-Ohno, Atsushi [Helmholtz-Zentrum Dresden-Rossendorf e.V., Dresden (Germany). Chemistry of the F-Elements

    2017-06-01

    We report herein the synthesis and characterization of several imine complexes of tetravalent thorium (Th(IV)) and uranium (U(IV)). The ligands investigated in this study are a Schiff base type, including the well-known salen ligand (H{sub 2}Le, Fig. 1). The complexation in solution was investigated by NMR measurements indicating paramagnetic effects of unpaired f-electrons of U(IV) on the ligand molecule. We also determined the solid-state molecular structures of the synthesized complexes by single crystal X-ray diffraction. The synthesized complexes show an eight-fold coordination geometry around the actinide center surrounded by two tetradentate ligands with 2N- and 2O-donor atoms.

  14. The kinetics of the cerium(IV)-uranium(IV) reaction at low sulfate concentrations

    International Nuclear Information System (INIS)

    Michaille, P.; Kikindai, T.

    1977-01-01

    The rate of oxidation of uranium(IV) by cerium(IV) was measured with a stopped-flow spectrophotometer at sulfuric acid concentrations of 2 x 10 -6 to 0.5 M. At a constant hydrogen ion concentration of 0.5 M, the maximum rate constant was observed for 2 x 10 -3 M sulfuric acid; at that concentration, two sulfate ions were involved in the activated complex. The dependence of the rate constant on the hydrogen ion concentration showed that the reaction paths involving one or two sulfate ions also involved one hydroxyl ion, whereas one hydrogen ion was involved in the five sulfate dependent path. Spectrophotometric measurements supported the existence of a hydrolyzed monosulfatocomplex of cerium(IV). (author)

  15. Thorium(IV) and zirconium(IV) complexes of oxygen donor ligands. Pt. 12

    International Nuclear Information System (INIS)

    Agarwal, R.K.; Jain, P.C.; Kapur, V.; Sharma, S.; Srivastava, A.K.

    1980-01-01

    Crystalline thorium (IV) chelates with mono N-oxides of 2,2'-bipyridine (bipyNO) and 1,10-phenanthroline (phenNO), ThX 4 x 2L(X = Cl,Br,NO 3 or NCS) and ThX 4 x 3L(X = I or ClO 4 and L = bipyNO or phenNO) have been synthesised and characterized on the basis of i.r. spectra, molar conductance, molecular weights, t.g.a. and d.t.a. data. All the complexes are weakly diamagnetic and contain bipyNO and phenNO bonded to thorium(IV) through nitrogen and oxygen. The coordination number of thorium(IV) varies from six to twelve depending on the nature of the anions. (orig.) [de

  16. General report of Technical Committee IV

    International Nuclear Information System (INIS)

    Feinendegen, L.E.

    1979-01-01

    During the report period, work in section IV of the Committee was continued on the molecular, cellular and organic levels with the aim to elucidate the origin, course and treatment possibility of the syndrome that may occur in the mammalian organism upon acute and chronic ionizing irradiation as a function of the radiation dose received. The investigations dealt a.o. with the effect of O 2 in protein radiolysis, recovery processes of the haematopoietic stem cells, delayed effects in the gastrointestical tract subsequent to local irradiation, and combination damage in the lungs and liver of rats upon combined cytostatic and radiation therapy. (orig./HP) [de

  17. Research in collegiate mathematics education IV

    CERN Document Server

    Dubinsky, Ed; Kaput, Jim

    2001-01-01

    This fourth volume of Research in Collegiate Mathematics Education (RCME IV) reflects the themes of student learning and calculus. Included are overviews of calculus reform in France and in the U.S. and large-scale and small-scale longitudinal comparisons of students enrolled in first-year reform courses and in traditional courses. The work continues with detailed studies relating students' understanding of calculus and associated topics. Direct focus is then placed on instruction and student comprehension of courses other than calculus, namely abstract algebra and number theory. The volume co

  18. A Gaussian IV estimator of cointegrating relations

    DEFF Research Database (Denmark)

    Bårdsen, Gunnar; Haldrup, Niels

    2006-01-01

    In static single equation cointegration regression modelsthe OLS estimator will have a non-standard distribution unless regressors arestrictly exogenous. In the literature a number of estimators have been suggestedto deal with this problem, especially by the use of semi-nonparametricestimators. T......In static single equation cointegration regression modelsthe OLS estimator will have a non-standard distribution unless regressors arestrictly exogenous. In the literature a number of estimators have been suggestedto deal with this problem, especially by the use of semi...... in cointegrating regressions. These instruments are almost idealand simulations show that the IV estimator using such instruments alleviatethe endogeneity problem extremely well in both finite and large samples....

  19. Topological characterisation and identification of critical domains within glucosyltransferase IV (GtrIV of Shigella flexneri

    Directory of Open Access Journals (Sweden)

    Nair Anesh

    2011-12-01

    Full Text Available Abstract Background The three bacteriophage genes gtrA, gtrB and gtr(type are responsible for O-antigen glucosylation in Shigella flexneri. Both gtrA and gtrB have been demonstrated to be highly conserved and interchangeable among serotypes while gtr(type was found to be specific to each serotype, leading to the hypothesis that the Gtr(type proteins are responsible for attaching glucosyl groups to the O-antigen in a site- and serotype- specific manner. Based on the confirmed topologies of GtrI, GtrII and GtrV, such interaction and attachment of the glucosyl groups to the O-antigen has been postulated to occur in the periplasm. Results In this study, the topology of GtrIV was experimentally determined by creating different fusions between GtrIV and a dual-reporter protein, PhoA/LacZ. This study shows that GtrIV consists of 8 transmembrane helices, 2 large periplasmic loops, 2 small cytoplasmic N- and C- terminal ends and a re-entrant loop that occurs between transmembrane helices III and IV. Though this topology differs from that of GtrI, GtrII, GtrV and GtrX, it is very similar to that of GtrIc. Furthermore, both the N-terminal periplasmic and the C-terminal periplasmic loops are important for GtrIV function as shown via a series of loop deletion experiments and the creation of chimeric proteins between GtrIV and its closest structural homologue, GtrIc. Conclusion The current study provides the basis for elucidating the structure and mechanism of action of this important O-antigen modifying glucosyltransferase.

  20. Discusión: Explicaciones genéticas y psicológicas de la esquizofrenia. Bases genéticas de la esquizofrenia: "Nurture vrs Nature

    Directory of Open Access Journals (Sweden)

    Henriette Raventós-Vorst

    2003-01-01

    Full Text Available El presente artículo revisa la evidencia científica que muestra la heredabilidad de la esquizofrenia, su forma de herencia compleja y la posible heterogeneidad genética y ambiental. Se presentan las regiones cromosómicas que han sido ligadas a la enfermedad y algunos de los genes candidatos. El objetivo es presentar los resultados más importantes en el campo de la investigación genética de la enfermedad. Aunque se acepta que factores ambientales deben estar presentes en la etiopatogenia de la enfermedad, no se profundiza en ellos. Finalmente, se comenta el modelo lamarquiano sugerido por el Prof.. Bolaños. El fin es transmitir que en la actualidad no hay contradicción entre el modelo biologista o psicológico que explicaban esta enfermedad. La concepción moderna une ambos modelos: se considera una enfermedad del neurodesarrollo en la que participan factores genéticos, factores epigenéticos y noxas ambientales, incluyendo los factores psicosociales.