24 CFR 891.560 - HAP contract.

Science.gov (United States)

2010-04-01

... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false HAP contract. 891.560 Section 891... Assistance § 891.560 HAP contract. (a) HAP contract. The housing assistance payments contract sets forth.... (b) HAP contract execution. (1) Upon satisfactory completion of the project, the Borrower and HUD...

IDENTIFICACIÓN DE HIDROCARBUROS AROMÁTICOS POLICÍCLICOS (HAPS EN EL AIRE DE CÚCUTA-COLOMBIA: EFECTO GEN TÓXICO

Directory of Open Access Journals (Sweden)

Alfonso Quijano Parra

Full Text Available En los últimos tiempos ha tomado un gran auge en los países del tercer mundo, incluidos los de América Latina, el estudio de la exposición humana a las emisiones de combustión, incluyendo las partículas ultrafinas (PM2,5 y componentes mutagénicos y carcinógenos como los hidrocarburos aromáticos policíclicos (HAPs. En este trabajo se identificó en la ciudad de Cúcuta un grupo de HAPs reconocidos por su afectación a la salud de la población; los HAPs encontrados fueron: metilcriseno, benzo[a]antraceno, benzo[j]fluoranteno, benzo[b]fluoranteno, benzo[a]pireno, dibenzo[a,l]pireno, dibenzo[a,e]pireno, benzo[c]fluoreno, benzo[k]fluoranteno, Indeno[1,2,3-cd]pireno, dibenzo[a,h]antraceno y benzo[g,h.i]perileno. Adicionalmente también se evaluó in vitro usando el ensayo cometa, el efecto genotóxico del material particulado PM2,5 extraído con acetona y diclorometano.

Arnold Rüütel: 1994. aasta kevad ja suvi / Arnold Rüütel ; intervjueerinud Toivo Tootsen

Index Scriptorium Estoniae

Rüütel, Arnold, 1928-

2003-01-01

1994. aasta kevad-sügisel raadiosaate "Keskööprogramm" jaoks tehtud intervjuud Arnold Rüütliga. Vabariigi Presidendi kõne Eesti Vabariigi 85. aastapäeval Estonia teatris 24. veebruaril 2003. Fotod

Kolmogorov-Arnold-Moser Theorem

Indian Academy of Sciences (India)

system (not necessarily the 2-body system). Kolmogorov was the first to provide a solution to the above general problem in a theorem formulated in 1954 (see Suggested. Reading). However, he provided only an outline of the proof. The actual proof (with all the details) turned to be quite difficult and was provided by Arnold ...

Arnold Rüütel: Eesti riigipead peaks valima rahvas või valijamehed / Arnold Rüütel ; intervjueerinud Tuuli Koch, Ingvar Bärenklau

Index Scriptorium Estoniae

Rüütel, Arnold, 1928-

2006-01-01

Ilmunud ka: Postimees : na russkom jazõke (2006) 14. sept., lk. 4-5; Virumaa Teataja (2006) 20. sept., lk. 6, pealk.: Arnold Rüütel presidendivalimisi Riigikogule ei usaldaks, lüh. President Arnold Rüütel pooldab presidendi otsevalimist või ilma Riigikogu vooruta kohe valimiskogus, tutvustab oma valimisplatvormi, räägib oma tervisest ja presidendiametist. Vt. samas: Rüütel: üks aasta selles neetud keskkomitee sekretäri ametis

Integrated Satellite-HAP Systems

DEFF Research Database (Denmark)

Cianca, Ernestina; De Sanctis, Mauro; De Luise, Aldo

2005-01-01

Thus far, high-altitude platform (HAP)-based systems have been mainly conceived as an alternative to satellites for complementing the terrestrial network. This article aims to show that HAP should no longer be seen as a competitor technology by investors of satellites, but as a key element for an...

40 CFR Table 2 to Subpart Tttt of... - Leather Finishing HAP Emission Limits for Determining the Allowable HAP Loss

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 12 2010-07-01 2010-07-01 true Leather Finishing HAP Emission Limits for Determining the Allowable HAP Loss 2 Table 2 to Subpart TTTT of Part 63 Protection of Environment... Finishing HAP Emission Limits for Determining the Allowable HAP Loss As required in § 63.5450, you must meet...

40 CFR 63.2465 - What requirements must I meet for process vents that emit hydrogen halide and halogen HAP or HAP...

Science.gov (United States)

2010-07-01

... process vents that emit hydrogen halide and halogen HAP or HAP metals? 63.2465 Section 63.2465 Protection... and halogen HAP or HAP metals? (a) You must meet each emission limit in Table 3 to this subpart that... section. (b) If any process vents within a process emit hydrogen halide and halogen HAP, you must...

40 CFR Table 1 to Subpart Tttt of... - Leather Finishing HAP Emission Limits for Determining the Allowable HAP Loss

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 12 2010-07-01 2010-07-01 true Leather Finishing HAP Emission Limits for Determining the Allowable HAP Loss 1 Table 1 to Subpart TTTT of Part 63 Protection of Environment... Finishing HAP Emission Limits for Determining the Allowable HAP Loss As required in §§ 63.5305 and 63.5340(b...

President Arnold Rüütel siirdas Kalevipojale südame / Meelis Lainvoo

Index Scriptorium Estoniae

Lainvoo, Meelis

2003-01-01

Rakvere Teatri suvelavastuse "Kalevipoeg" viimasel etendusel osalesid Arnold ja Ingrid Rüütel ning poliitikud Tõnis Palts, Tõnis Lukas, Arvo Haug ja Tõnu Kõiv. President Arnold Rüütel pani Neerutis Sadulamäel Kalevipoja kujule viimase kivi. Skulptuuri autori Seaküla Simsoni kommentaar

24 CFR 891.580 - HAP contract administration.

Science.gov (United States)

2010-04-01

... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false HAP contract administration. 891... Handicapped-Section 8 Assistance § 891.580 HAP contract administration. HUD is responsible for the administration of the HAP contract. ...

40 CFR Table 3 to Subpart Ffff of... - Emission Limits for Hydrogen Halide and Halogen HAP Emissions or HAP Metals Emissions From...

Science.gov (United States)

2010-07-01

... Halogen HAP Emissions or HAP Metals Emissions From Process Vents 3 Table 3 to Subpart FFFF of Part 63... to Subpart FFFF of Part 63—Emission Limits for Hydrogen Halide and Halogen HAP Emissions or HAP... following table that applies to your process vents that contain hydrogen halide and halogen HAP emissions or...

What Arnold Gesell Would Advocate Today

Science.gov (United States)

Bergen, Doris

2017-01-01

The first issue of "Childhood Education," published in 1924, included an article by the eminent physician, Arnold Gesell. In the article, "The Significance of the Nursery School" he advocated for early childhood education, indicating its importance for both promoting the development of young children and supporting and…

HAPS, a Handy Analog Programming System

DEFF Research Database (Denmark)

Højberg, Kristian Søe

1975-01-01

HAPS (Hybrid Analog Programming System) is an analog compiler that can be run on a minicomputer in an interactive mode. Essentially HAPS is written in FORTRAN. The equations to be programmed for an ana log computer are read in by using a FORTRAN-like notation. The input must contain maximum...... and emphasizes the limitations HAPS puts on equation structure, types of computing circuit, scaling, and static testing....

Matthew Arnold and Minimal Competency Testing.

Science.gov (United States)

Tuman, Myron C.

1979-01-01

Presents arguments by Robert Lowe and Matthew Arnold on the 19th century British "Payment by Results" Plan, whereby schools received funds for students who passed minimal competency tests. Emphasizes that the Victorian experience produced acrimonious teachers with low morale and encourages contemporary minimal testing advocates not to…

President Arnold Rüütel : kui ma poleks president, siis oleksin talupidaja / Arnold Rüütel ; intervjueerinud Toivo Tänavsuu

Index Scriptorium Estoniae

Rüütel, Arnold, 1928-

2005-01-01

President Arnold Rüütel vastab küsimustele, mis puudutavad Ettevõtluse Auhinna konkurssi, EL-iga liitumisega kaasnenud eeliseid Eesti majandusele, lähiaastatel lahendamist vajavaid probleeme Eesti majanduses

24 CFR 983.202 - Purpose of HAP contract.

Science.gov (United States)

2010-04-01

... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false Purpose of HAP contract. 983.202... DEVELOPMENT PROJECT-BASED VOUCHER (PBV) PROGRAM Housing Assistance Payments Contract § 983.202 Purpose of HAP contract. (a) Requirement. The PHA must enter into a HAP contract with the owner. The HAP contract must be...

24 CFR 891.565 - Term of HAP contract.

Science.gov (United States)

2010-04-01

... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false Term of HAP contract. 891.565... 8 Assistance § 891.565 Term of HAP contract. The term of the HAP contract for assisted units shall be 20 years. If the project is completed in stages, the term of the HAP contract for assisted units...

Characterization of a new sealer MTA/HAp; Caracterizacao de um novo cimento endodontico MTA/HAp

Energy Technology Data Exchange (ETDEWEB)

Barros, C.M.B.; Oliveira, S.V.; Costa, A.C.F.M. [Universidade Federal de Campina Grande (UFCG), PB (Brazil); Dantas, D.C.R.E.; Fontes, L.B.C. [Universidade Estadual da Paraiba (UEPB), PB (Brazil); Viana, K.M.S., E-mail: kalineviana@ect.ufrn.br [Universidade Federal do Rio Grande do Norte (UFRN), Natal, RN (Brazil)

2012-07-01

Filling materials (cement-based calcium hydroxide, amalgam, glass ionomer and IRM) are often used as sealers. However, none of them meets the desirable characteristics of a suitable sealing material. This study aims to characterize the new sealer, MTA/HAp from the incorporation of 5% by weight of synthetic hydroxyapatite to the MTA and to investigate the influence of the addition of HAp on the characteristic structural, chemical and consistency of the MTA. For this, we used MTA Angelus ® and HAp synthesized in the laboratory. We used the ratio by mass 95%MTA/5%HAp, where the hydroxyapatite added the characteristic of the MTA osteoconduction. The tests were performed: XRD, XRF and consistency. The results showed that both the new cement had the same crystalline phases as the same chemical composition of its precursors, yet having suitable consistency (plastic mass) of a sealer as well as the pure MTA. (author)

24 CFR 983.203 - HAP contract information.

Science.gov (United States)

2010-04-01

... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false HAP contract information. 983.203... DEVELOPMENT PROJECT-BASED VOUCHER (PBV) PROGRAM Housing Assistance Payments Contract § 983.203 HAP contract information. The HAP contract must specify: (a) The total number of contract units by number of bedrooms; (b...

Arnold Rüütel: e-hääletamine tuleb niikuinii / Arnold Rüütel ; intervjueerinud Kai Kalamees

Index Scriptorium Estoniae

Rüütel, Arnold, 1928-

2005-01-01

President Arnold Rüütel vastab küsimustele, mis on seotud tema otsusega mitte kuulutada välja e-hääletamist lubavat seadust. Presidendi sõnul ei mõjuta tema otsus kuidagi e-hääletuse tänavust toimumist

HAp physical investigation - the effect of sintering temperature

International Nuclear Information System (INIS)

Mohd Reusmaazran Yusof; Idris Besar; Rusnah Mustaffa; Cik Rohaida Che Hak

2004-01-01

The paper presents the effect of sintering temperature on the physical properties of porous hydroxyapatite (HAp). In this study, the HAp was prepared using polymeric sponge techniques with different binder concentration. The sintering process was carried out in air for temperature ranging from 1200 degree C to 1600 degree C. Different physical properties namely density and porosity were observed at different sintering temperatures. The HAp prepared with higher PVP binder showed a slightly decreased in apparent density with increasing sintering temperature, while those HAp prepared with lower PVP showed a slightly increase in apparent density with increasing sintering temperature. The total porosity was found to be approximately constant in the whole sintering temperature range. However, closed porosity decreases with increasing sintering temperature for HAp prepared by lower binder concentration. On the other hand, the HAp prepared by higher binder concentration HAp showed increasing closed porosity with increasing sintering temperature. Other features such as the influence of sintering temperatures on grain and strut also be presented in this paper. (Author)

President Arnold Rüütel : "Me ei tohi seda teed enam edasi minna" / Arnold Rüütel ; intervjueerinud Harda Roosna

Index Scriptorium Estoniae

Rüütel, Arnold, 1928-

2006-01-01

President Arnold Rüütli visiidist Hiiumaale. President vastas küsimustele meditsiini, tööhõive, päästeteenistuse kohta. Vabariigi President Hiiumaal 26.-27.07.2006. Vt. samas: President poebussis ja kirikus

Intersystem Interference Reduction for Overlaid HAPS-Terrestrial CDMA System

Science.gov (United States)

Huang, Jeng-Ji; Wang, Wei-Ting; Li, Mingfu; Shiung, David; Ferng, Huei-Wen

In this letter, we propose that directional antennas, combined with power management, be incorporated to reduce intersystem interference in a shared band overlaid high altitude platform station (HAPS)-terrestrial code division multiple access (CDMA) system. To eliminate the HAPS to terrestrial interference, the HAPS is accessed only via directional antennas under the proposed scheme. By doing so, the uplink power to the HAPS can accordingly be increased, so that the terrestrial to HAPS interference is also effectively suppressed.

24 CFR 983.204 - When HAP contract is executed.

Science.gov (United States)

2010-04-01

... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false When HAP contract is executed. 983... When HAP contract is executed. (a) PHA inspection of housing. (1) Before execution of the HAP contract... into a HAP contract for any contract unit until the PHA has determined that the unit complies with the...

24 CFR 891.590 - Notice upon HAP contract expiration.

Science.gov (United States)

2010-04-01

... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false Notice upon HAP contract expiration... Handicapped-Section 8 Assistance § 891.590 Notice upon HAP contract expiration. (a) Notice required. The HAP contract will provide that the Borrower will, at least one year before the end of the HAP contract term...

An Awkward Echo: Matthew Arnold and John Dewey. Research in Curriculum and Instruction

Science.gov (United States)

Dietz, Mark David

2010-01-01

Matthew Arnold, 19th century English poet, literary critic and school inspector, felt that each age had to determine that philosophy that was most adequate to its own concerns and contexts. This study looks at the influence that Matthew Arnold had on John Dewey and attempts to fashion a philosophy of education that is adequate for our own…

Arnold Rüütel: "Kohati jääb meie erakondadel puudu sisemisest demokraatiast." / Arnold Rüütel ; intervjueerinud Urmo Soonvald

Index Scriptorium Estoniae

Rüütel, Arnold, 1928-

2004-01-01

President Arnold Rüütel vastab küsimustele, mis puudutavad vedurijuhtide streiki, noorte arstide lahkumist välismaale, Rahvaliidu saadikurühma tekkimist Tallinna volikogus, Res Publica ja Reformierakonna võimalikku liitumist, Leedu-visiiti

Optimization in obtaining PLA nanofibers/nHAP for pharmaceuticals release; Otimizacao na obtencao de nanofibras de PLA/nHAP para liberacao de farmacos

Energy Technology Data Exchange (ETDEWEB)

Becaro, A.A.; Paris, E.C.; Mattoso, L.H.C., E-mail: elaine.paris@embrapa.br [EMBRAPA Instrumentacao, Sao Carlos, SP (Brazil); Sciena, C.R.; Malafatti, J.D. [Universidade Federal de Sao Carlos (UFSCar), SP (Brazil). Departamento de Quimica

2016-07-01

Hydroxyapatite (HAP) belongs to the family of calcium apatites. In nanometric form (nHAP) can be used as a drug carrier. The objective was to improve PLA nanofibers with nHAP insert for use in drug delivery. nHAP were obtained by coprecipitation method and characterized by XRD and TEM techniques. PLA fibers (10%) and 5% nHAP were obtained at a distance of 6 cm and flow rate of 0.1, 0.3 and 0.5 ml h{sup -1}, and characterized by SEM. The nHAP were single phase with rod shape, rounded tip and from 10 to 20 nm in diameter. The fibers obtained from pure PLA had to be more porous than in the presence of HAP. The diameters ranged from 0.2 to 2.4 micrometers. Among the fibers obtained that showed the best result was to flow 0.3 ml h{sup -1}. (author)

Antenna Beam Pattern Characteristics of HAPS User Terminal

Science.gov (United States)

Ku, Bon-Jun; Oh, Dae Sub; Kim, Nam; Ahn, Do-Seob

High Altitude Platform Stations (HAPS) are recently considered as a green infrastructure to provide high speed multimedia services. The critical issue of HAPS is frequency sharing with satellite systems. Regulating antenna beam pattern using adaptive antenna schemes is one of means to facilitate the sharing with a space receiver for fixed satellite services on the uplink of a HAPS system operating in U bands. In this letter, we investigate antenna beam pattern characteristics of HAPS user terminals with various values of scan angles of main beam, null position angles, and null width.

Arnold Gesell and the maturation controversy.

Science.gov (United States)

Dalton, Thomas C

2005-01-01

This article examines the work of Arnold Lucius Gesell and argues that he not only paved the way for contemporary research in motor development, but that he and colleagues anticipated fundamental issues about growth that must be addressed by psychologists and neuroscientists who are committed to the advancement of developmental science. Arnold Lucius Gesell was a pioneer in developmental psychology when the field was in its infancy. He worked diligently for the rights of physically and mentally handicapped children to receive special education that would enable them to find gainful employment. Gesell's writings in books and popular magazines increased public awareness of and support for preschool education and better foster care for orphans. Despite these achievements, many of his successors have questioned his views about infant development. Developmental psychologists have criticized Gesell for proposing a stage theory of infant growth that has fallen into disfavor among contemporary researchers. His conception of development as a maturational process has been challenged for allegedly reducing complex behavioral, perceptual, and learning processes to genetic factors. The author rejects this overly simplistic interpretation and contends that Gesell's work continues to stand the test of time.

24 CFR 983.205 - Term of HAP contract.

Science.gov (United States)

2010-04-01

... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false Term of HAP contract. 983.205... DEVELOPMENT PROJECT-BASED VOUCHER (PBV) PROGRAM Housing Assistance Payments Contract § 983.205 Term of HAP contract. (a) Ten-year initial term. The PHA may enter into a HAP contract with an owner for an initial...

Revalidacion de Bombax Ceiba L. como especie típica del genero Bombax L. y descripcion de Pseudobombax gen. nov

Directory of Open Access Journals (Sweden)

Dugand Armando

1943-04-01

Full Text Available En este trabajo se determina por razones históricas que Bombax Ceiba L. es la especie típica del genero Bombax L. y se tipifica dicha especie a su vez sobre Bombax quinatum Jacq. Refútase así la recomendación de B. malabaricum DC. como lectotipo de Bombax. Se propone una nueva definición, sensu maxime strictissimo, de Bombax L. y de B. Ceiba L. fundada en B. quinatum Jacq.; se mencionan los sinónimos conocidos y los ejemplares botánicos examinados. Esta tipificación causa una completa alteración del concepto genérico de Bombax por cuanto B. quinatum ha sido considerado generalmente como representativo de un género intermedio (Bombacopsis Pittier cuya definición sistemática resulta ahora justamente aplicable al genera linneano. Por consiguiente es necesario hacer un ajuste nomenclatural y se propone una nueva denominación genérica (Pseudobombax Dugand que abarca, por lo pronto, tres especies: septenatum Jacq. (como tipo , ellipticum HBK. y Palmeri S. Wats., antes considerados como verdaderos Bombax. La preparación de este estudio fue realizada en su mayor parte compilando numerosos datos históricos en las bibliotecas del Arnold Arboretum y del Gray Herbarium, merced a las prerrogativas que me fueron generosamente concedidas por la Universidad de Harvard al designarme Research Fellow del Arnold Arboretum durante la visita que hice recientemente a varias instituciones botanicas de los Estados Unidos como invitado del Comité de Relaciones Artísticas e Intelectuales Inter-Americanas.

Hap1 and GABA: thinking about food intake.

Science.gov (United States)

Woods, Stephen C; Seeley, Randy J

2006-06-01

GABA stimulation of hypothalamic GABAA receptors increases food intake and body weight. Huntingtin-associated protein-1 (Hap1), is highly expressed in the hypothalamus and increases activity at GABAA receptors; mice lacking Hap1 are hypophagic. A recent paper (Sheng et al.,2006) further explores the role of Hap1 in the control of food intake.

Difusión de Arnold en un modelo simple

Science.gov (United States)

Cincotta, P. M.; Nuñez, J. A.; Miloni, O.

Investigadores como Merritt, Valluri, Pfenniger o Contopoulos (por citar los más relevantes) consideran seriamente la hipótesis que la difusión de Arnold juega un rol importante en la evolución dinámica de los sistemas estelares y planetarios. Sin embargo no existe ninguna evidencia. El mayor problema para investigar fenómenos como éste es que uno debe estudiar numéricamente sistemas multidimensionales (más de dos grados de libertad) y visualizar de alguna manera el espacio de fases (más de cuatro dimensiones). Más complicado aún es el caso de difusión de Arnold, donde deben considerarse tiempos de movimiento extremadamente largos y tratar con parámetros exponencialmente pequeños. El propósito de este trabajo es estudiar, en un modelo simple 3D, la existencia o no de difusión de Arnold mediante experimentos numéricos y estimaciones analíticas. Siguiendo los trabajos de Cincotta (2000) y Cincotta, Nuñez y Simo (2000), aquí se pretende ``visualizar" la difusión y, a la vez, determinar la escala de tiempo en la que ésta se podría manifestar. Este trabajo es el escalón inicial para luego abordar este problema en modelos.

President Arnold Rüütel tahab anda noortele peredele maad / Mati Määrits

Index Scriptorium Estoniae

Määrits, Mati, 1958-

2005-01-01

Põlvamaa omavalitsusjuhid avaldasid toetust president Arnold Rüütli ettepanekule anda maad eelkõige noortele peredele. Presidendi juuresolekul ei leitud aga üksmeelt haridusinvesteeringute jaotamises laste arvust lähtudes. President Arnold Rüütel vastab küsimusele, kas kaks päeva Põlvamaal suutsid teda millegagi üllatada. Maakonnavisiit Põlvamaale 08.-09.06.2005

Presidentidest usaldas rahvas kõige enam Arnold Rüütlit / Vahur Koorits

Index Scriptorium Estoniae

Koorits, Vahur, 1981-

2009-01-01

Kaitseministeeriumi korraldatud institutsioonide usaldusväärsuse küsitlusest selgus, et president Arnold Rüütlit usaldas tema ametiajal keskmiselt 79 % Eesti inimestest. President Toomas Hendrik Ilves pälvis 73 % vastanute usalduse ja president Lennart Meri usaldas tema viimasel ametiaastal 70 % küsitletutest. Lisatud joonis: Usaldus taasiseseisvuseaegsete presidentide vastu (aastatel 2001-2008). Arvamust avaldavad president Arnold Rüütel, Postimehe kolumnist Enn Soosaar, uuringufirma Saar Poll juhataja Andrus Saar ja president T. H. Ilvese avalike suhete nõunik Toomas Sildam

Chitosan Fibers Modified with HAp/β–TCP Nanoparticles

Directory of Open Access Journals (Sweden)

Dariusz Wawro

2011-10-01

Full Text Available This paper describes a method for preparing chitosan fibers modified with hydroxyapatite (HAp, tricalcium phosphate (β-TCP, and HAp/β-TCP nanoparticles. Fiber-grade chitosan derived from the northern shrimp (Pandalus borealis and nanoparticles of tricalcium phosphate (β-TCP and hydroxyapatite (HAp suspended in a diluted chitosan solution were used in the investigation. Diluted chitosan solution containing nanoparticles of Hap/β-TCP was introduced to a 5.16 wt% solution of chitosan in 3.0 wt% acetic acid. The properties of the spinning solutions were examined. Chitosan fibers modified with nanoparticles of HAp/β-TCP were characterized by a level of tenacity and calcium content one hundred times higher than that of regular chitosan fibers.

40 CFR Table 7 to Subpart Vvvvvv... - Partially Soluble HAP

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 14 2010-07-01 2010-07-01 false Partially Soluble HAP 7 Table 7 to... Pt. 63, Subpt. VVVVVV, Table 7 Table 7 to Subpart VVVVVV of Part 63—Partially Soluble HAP As required... partially soluble HAP listed in the following table. Partially soluble HAP name CAS No. 1. 1,1,1...

Optimization in obtaining PLA nanofibers/nHAP for pharmaceuticals release

International Nuclear Information System (INIS)

Becaro, A.A.; Paris, E.C.; Mattoso, L.H.C.; Sciena, C.R.; Malafatti, J.D.

2016-01-01

Hydroxyapatite (HAP) belongs to the family of calcium apatites. In nanometric form (nHAP) can be used as a drug carrier. The objective was to improve PLA nanofibers with nHAP insert for use in drug delivery. nHAP were obtained by coprecipitation method and characterized by XRD and TEM techniques. PLA fibers (10%) and 5% nHAP were obtained at a distance of 6 cm and flow rate of 0.1, 0.3 and 0.5 ml h"-"1, and characterized by SEM. The nHAP were single phase with rod shape, rounded tip and from 10 to 20 nm in diameter. The fibers obtained from pure PLA had to be more porous than in the presence of HAP. The diameters ranged from 0.2 to 2.4 micrometers. Among the fibers obtained that showed the best result was to flow 0.3 ml h"-"1. (author)

Recombinant C-terminal 311 amino acids of HapS adhesin as a vaccine candidate for nontypeable Haemophilus influenzae: A study on immunoreactivity in Balb/C mouse.

Science.gov (United States)

Tabatabaee Bafroee, Akram Sadat; Siadat, Seyed Davar; Mousavi, Seyed Fazlollah; Aghasadeghi, Mohammad Reza; Khorsand, Hashem; Nejati, Mehdi; Sadat, Seyed Mehdi; Mahdavi, Mehdi

2016-09-01

Hap, an auto-transporter protein, is an antigenically conserved adhesion protein which is present on both typeable and nontypeable Haemophilus influenzae. This protein has central role in bacterial attachment to respiratory tract epithelial cells. A 1000bp C-terminal fragment of Hap passenger domain (HapS) from nontypeable Haemophilus influenzae was cloned into a prokaryotic expression vector, pET-24a. BALB/c mice were immunized subcutaneously with purified rC-HapS. Serum IgG responses to purified rC-HapS, serum IgG subclasses were determined by ELISA and functional activity of antibodies was examined by Serum Bactericidal Assay. The output of rC-HapS was approximately 62% of the total bacterial proteins. Serum IgG responses were significantly increased in immunized group with rC-HapS mixed with Freund's adjuvant in comparison with control groups. Analysis of the serum IgG subclasses showed that the IgG1 subclass was predominant after subcutaneous immunization in BALB/c mice (IgG2a/IgG1 HapS immunized animals were strongly bactericidal against nontypeable Haemophilus influenzae. These results suggest that rC-HapS may be a potential vaccine candidate for nontypeable Haemophilus influenzae. Copyright © 2016 Elsevier Ltd. All rights reserved.

Essays in mathematics and its applications in honor of Vladimir Arnold

CERN Document Server

Pardalos, Panos

2016-01-01

This volume, dedicated to the eminent mathematician Vladimir Arnold, presents a collection of research and survey papers written on a large spectrum of theories and problems that have been studied or introduced by Arnold himself. Emphasis is given to topics relating to dynamical systems, stability of integrable systems, algebraic and differential topology, global analysis, singularity theory and classical mechanics. A number of applications of Arnold’s groundbreaking work are presented. This publication will assist graduate students and research mathematicians in acquiring an in-depth understanding and insight into a wide domain of research of an interdisciplinary nature.

24 CFR 982.603 - SRO: Lease and HAP contract.

Science.gov (United States)

2010-04-01

... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false SRO: Lease and HAP contract. 982... Types Single Room Occupancy (sro) § 982.603 SRO: Lease and HAP contract. For SRO housing, there is a separate lease and HAP contract for each assisted person. ...

Biochemical Removal of HAP Precursors From Coal

Energy Technology Data Exchange (ETDEWEB)

Olson, G.; Tucker, L.; Richards, J.

1997-07-01

This project addresses DOE`s interest in advanced concepts for controlling emissions of air toxics from coal-fired utility boilers. We are determining the feasibility of developing a biochemical process for the precombustion removal of substantial percentages of 13 inorganic hazardous air pollutant (HAP) precursors from coal. These HAP precursors are Sb, As, Be, Cd, Cr, Cl, Co, F, Pb, Hg, Mn, Ni, and Se. Although rapid physical coal cleaning is done routinely in preparation plants, biochemical processes for removal of HAP precursors from coal potentially offer advantages of deeper cleaning, more specificity, and less coal loss. Compared to chemical processes for coal cleaning, biochemical processes potentially offer lower costs and milder process conditions. Pyrite oxidizing bacteria, most notably Thiobacillusferrooxidans, are being evaluated in this project for their ability to remove HAP precursors from U.S. coals.

Biochemical Removal of HAP Precursors From Coal

International Nuclear Information System (INIS)

Olson, G.; Tucker, L.; Richards, J.

1997-07-01

This project addresses DOE's interest in advanced concepts for controlling emissions of air toxics from coal-fired utility boilers. We are determining the feasibility of developing a biochemical process for the precombustion removal of substantial percentages of 13 inorganic hazardous air pollutant (HAP) precursors from coal. These HAP precursors are Sb, As, Be, Cd, Cr, Cl, Co, F, Pb, Hg, Mn, Ni, and Se. Although rapid physical coal cleaning is done routinely in preparation plants, biochemical processes for removal of HAP precursors from coal potentially offer advantages of deeper cleaning, more specificity, and less coal loss. Compared to chemical processes for coal cleaning, biochemical processes potentially offer lower costs and milder process conditions. Pyrite oxidizing bacteria, most notably Thiobacillusferrooxidans, are being evaluated in this project for their ability to remove HAP precursors from U.S. coals

President kutsub koostööle / Arnold Rüütel

Index Scriptorium Estoniae

Rüütel, Arnold, 1928-

2002-01-01

Ilmunud ka: Postimees (2002) 25. veebr., lk. 11, pealk.: Vajame uut ühiskondlikku lepet; SL Õhtuleht (2002) 25. veebr., lk. 10, pealk.: Aeg rahvuslikuks leppeks, vt. samas karikatuur; Virumaa Teataja (2002) 26. veebr., lk. 7, pealk.: Eestis tuleb taastada sotsiaalne tasakaal; Maaleht (2002) 28. veebr., lk. 8, pealk.: Uhkus ajab upakile; Põhjarannik (2002) 26. veebr., lk. 5, pealk.: President Arnold Rüütli kõne Eesti Vabariigi 84. aastapäeval; Severnoje Poberezhje (2002) 26. veebr., lk. 5; Meie Maa (2002) 26. veebr., lk. 2, pealk.: Vajame põlvkondlikku järjepidevust ja uut ühiskondlikku lepet. President Arnold Rüütli kõne Eesti Vabariigi 84. aastapäeval Estonia teatris 24. veebruaril 2002. Lühendatult

Arnold Rüütli valimisplatvorm / Arnold Rüütel

Index Scriptorium Estoniae

Rüütel, Arnold, 1928-

2006-01-01

Ilmunud ka: Äripäev (2006) 13. sept., lk. 23, pealk.: Eesti peab olema inimestele turvaline kodu ; Kesknädal (2006) 13. sept., lk. 4-5, pealk.: Muudame riigi turvaliseks rahvakoduks ; Sakala (2006) 14. sept., lk. 2, pealk.: Eesti olgu inimestele turvaline kodu ; Pärnu Postimees (2006) 14. sept., lk. 15, pealk.: Eesti peab olema inimestele turvaline kodu ; Põhjarannik (2006) 14. sept., lk. 2, Eesti peab olema inimestele turvaline kodu ; Severnoje Poberezhje (2006) 14. sept., lk. 2 ; Vesti Nedeli Den za Dnjom (2006) 15. sept., lk. 20 ; Lääne-Harju Ekspress (2006) 16. sept., lk. 7 ; Hiiu Leht (2006) 19. sept., lk. 4. President Arnold Rüütel rõhutab oma valimisplatvormis, et Eesti ülim eesmärk on rahva püsimajäämine ja oma riigi hoidmine. Kommenteerib Toomas Hendrik Ilves. Lisa: Presidendikultuuri seitse alusmõtet. Ajal. Äripäev kommenteerib Aivar Hundimägi, T. H. Ilvese kommentaar ainult Eesti Päevalehes

ANAESTHETIC MANAGEMENT IN A PATIENT WITH ARNOLD-CHI ARI MALFORMATION TYPE I AND SYRINGOMYELIA

OpenAIRE

Kartika; Pratap; Vijayalaxmi; Kalyan Chakravarthy; Nagaraju

2013-01-01

ABSTRACT: Syringomyelia is an unusual neurological condition characterised by the the presence of cystic cavity in the spinal cord resultin g in neurological manifestations. Here, we report a safe anesthetic management of patient with Arnold-Ch iari malformation type I and syringomyelia posted for foramen magnum decompression . INTRODUCTION: Arnold-Chiari malformation (ACM) is a developmental malformation characterised by downward displacement of cere...

32 CFR 239.15 - List of HAP field offices.

Science.gov (United States)

2010-07-01

... 32 National Defense 2 2010-07-01 2010-07-01 false List of HAP field offices. 239.15 Section 239.15...) MISCELLANEOUS HOMEOWNERS ASSISTANCE PROGRAM-APPLICATION PROCESSING § 239.15 List of HAP field offices. Homeowners Assistance Program field offices that process HAP applications for installations and applicants...

24 CFR 982.455 - Automatic termination of HAP contract.

Science.gov (United States)

2010-04-01

... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false Automatic termination of HAP contract. 982.455 Section 982.455 Housing and Urban Development Regulations Relating to Housing and Urban... Payments Contract and Owner Responsibility § 982.455 Automatic termination of HAP contract. The HAP...

Analysis of the fuel influence in obtaining HAp by combustion reaction; Analise da influencia do combustivel na obtencao de HAp via reacao de combustao

Energy Technology Data Exchange (ETDEWEB)

Santos, T.L.; Leite, A.M.D.; Viana, K.M.S., E-mail: kalineviana@ect.ufrn.br [Universidade Federal do Rio Grande do Norte (UFRN), Natal, RN (Brazil). Escola de Ciencias e Tecnologia

2016-07-01

The search for new materials for biomedical applications has led to investigation of the calcium phosphate bioceramics, and in particular hydroxyapatite (HAp), being a material similar to bone tissue, with excellent biocompatibility and high osteoconduction, enabling bone regeneration which allows the use at implants and prostheses. The synthesis of the nanometric HAp by combustion reaction enables obtaining the nanometric HAp with a more similar structure biological apatite as possible. This work aims to synthesize HAp by combustion reaction using two different routes of synthesis, first, using urea as fuel and the second using glycine, after this, evaluate the influence of fuels used in the microstructure of the hydroxyapatite obtained. The HAp obtained was characterized by: XRD, FTIR and SEM. Through analysis of the results, there is the synthesis conditions used that glycine has performed more favorable to obtaining HAp. (author)

Structural Determinants of Autoproteolysis of the Haemophilus influenzae Hap Autotransporter▿

Science.gov (United States)

Kenjale, Roma; Meng, Guoyu; Fink, Doran L.; Juehne, Twyla; Ohashi, Tomoo; Erickson, Harold P.; Waksman, Gabriel; St. Geme, Joseph W.

2009-01-01

Haemophilus influenzae is a gram-negative bacterium that initiates infection by colonizing the upper respiratory tract. The H. influenzae Hap autotransporter protein mediates adherence, invasion, and microcolony formation in assays with respiratory epithelial cells and presumably facilitates colonization. The serine protease activity of Hap is associated with autoproteolytic cleavage and extracellular release of the HapS passenger domain, leaving the Hapβ C-terminal domain embedded in the outer membrane. Cleavage occurs most efficiently at the LN1036-37 peptide bond and to a lesser extent at three other sites. In this study, we utilized site-directed mutagenesis, homology modeling, and assays with a peptide library to characterize the structural determinants of Hap proteolytic activity and cleavage specificity. In addition, we used homology modeling to predict the S1, S2, and S4 subsite residues of the Hap substrate groove. Our results indicate that the P1 and P2 positions at the Hap cleavage sites are critical for cleavage, with leucine preferred over larger hydrophobic residues or other amino acids in these positions. The substrate groove is formed by L263 and N274 at the S1 subsite, R264 at the S2 subsite, and E265 at the S4 subsite. This information may facilitate design of approaches to block Hap activity and interfere with H. influenzae colonization. PMID:19687208

Arnold Rüütel: meie küla käis käest kätte / Arnold Rüütel ; intervjueerinud Enno Tammer

Index Scriptorium Estoniae

Rüütel, Arnold, 1928-

2005-01-01

President Arnold Rüütel Teise maailmasõjaga seotud mälestustest, Molotov-Ribbentropi paktist, Moskvas võidupüha tähistamisel mitteosalemise põhjustest ja 2006. a. presidendivalimistel osalemisest

Characterization of a new sealer MTA/HAp

International Nuclear Information System (INIS)

Barros, C.M.B.; Oliveira, S.V.; Costa, A.C.F.M.; Dantas, D.C.R.E.; Fontes, L.B.C.; Viana, K.M.S.

2012-01-01

Filling materials (cement-based calcium hydroxide, amalgam, glass ionomer and IRM) are often used as sealers. However, none of them meets the desirable characteristics of a suitable sealing material. This study aims to characterize the new sealer, MTA/HAp from the incorporation of 5% by weight of synthetic hydroxyapatite to the MTA and to investigate the influence of the addition of HAp on the characteristic structural, chemical and consistency of the MTA. For this, we used MTA Angelus ® and HAp synthesized in the laboratory. We used the ratio by mass 95%MTA/5%HAp, where the hydroxyapatite added the characteristic of the MTA osteoconduction. The tests were performed: XRD, XRF and consistency. The results showed that both the new cement had the same crystalline phases as the same chemical composition of its precursors, yet having suitable consistency (plastic mass) of a sealer as well as the pure MTA. (author)

Lennart Meri rännak jätkub ajaloos / Arnold Rüütel

Index Scriptorium Estoniae

Rüütel, Arnold, 1928-

2006-01-01

Ilmunud ka: Eesti Päevaleht 27. märts, lk. 3, pealkiri: VAbariigi presidendi Arnold Rüütli mälestuskõne president Lennart Mei ärasaatmisel Kadriorus, 26. märtsil 2006 SL Õhtuleht 27. märts lk. 2,8, Järva Teataja 28. märts lk. 2. Eesti Vabariigi presidendi Arnold Rüütli mälestuskõne president Lennart Meri riiklikul hüvastijätutseremoonial 26. märtsil 2006 Kadriorus

24 CFR 891.595 - HAP contract extension or renewal.

Science.gov (United States)

2010-04-01

... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false HAP contract extension or renewal... Handicapped-Section 8 Assistance § 891.595 HAP contract extension or renewal. Upon expiration of the term of the HAP contract, HUD and the Borrower may agree (subject to available funds) to extend the term of...

Arnold Rüütel: riigikogu peab hoiduma Iraagi küsimuses populismist / Arnold Rüütel ; intervjueerinud Urmet Kook

Index Scriptorium Estoniae

Rüütel, Arnold, 1928-

2006-01-01

President Arnold Rüütel vastab küsimustele, mis puudutavad tema tervist, presidendiks kandideerimist, tema maailmavaadet ja minevikku ning suhet religiooniga, Keskerakonna ja Rahvaliidu koostöölepingut, 1991. aasta putšistide nimetatud Eesti asevalitsejat, Venemaa hiljutist nooti seoses piirilepinguga, presidendi edasisi plaane, samuti tema suhtumist kohustuslikku religiooniõpetusse, Iraagi-missiooni pikendamisse, võõrtööjõu sissetoomisse

Structural determinants of the interaction between the Haemophilus influenzae Hap autotransporter and fibronectin.

Science.gov (United States)

Spahich, Nicole A; Kenjale, Roma; McCann, Jessica; Meng, Guoyu; Ohashi, Tomoo; Erickson, Harold P; St Geme, Joseph W

2014-06-01

Haemophilus influenzae is a Gram-negative cocco-bacillus that initiates infection by colonizing the upper respiratory tract. Hap is an H. influenzae serine protease autotransporter protein that mediates adherence, invasion and microcolony formation in assays with human epithelial cells and is presumed to facilitate the process of colonization. Additionally, Hap mediates adherence to fibronectin, laminin and collagen IV, extracellular matrix (ECM) proteins that are present in the respiratory tract and are probably important targets for H. influenzae colonization. The region of Hap responsible for adherence to ECM proteins has been localized to the C-terminal 511 aa of the Hap passenger domain (HapS). In this study, we characterized the structural determinants of the interaction between HapS and fibronectin. Using defined fibronectin fragments, we established that Hap interacts with the fibronectin repeat fragment called FNIII(1-2). Using site-directed mutagenesis, we found a series of motifs in the C-terminal region of HapS that contribute to the interaction with fibronectin. Most of these motifs are located on the F1 and F3 faces of the HapS structure, suggesting that the F1 and F3 faces may be responsible for the HapS-fibronectin interaction. © 2014 The Authors.

Household air pollution (HAP), microenvironment and child health: Strategies for mitigating HAP exposure in urban Rwanda

Science.gov (United States)

Das, Ipsita; Pedit, Joseph; Handa, Sudhanshu; Jagger, Pamela

2018-04-01

Exposure to household air pollution (HAP) from cooking and heating with solid fuels is a major risk factor for morbidity and mortality in sub-Saharan Africa. Children under five are particularly at risk for acute lower respiratory infection. We use baseline data from a randomized controlled trial evaluating a household energy intervention in Gisenyi, Rwanda to investigate the role of the microenvironment as a determinant of children’s HAP-related health symptoms. Our sample includes 529 households, with 694 children under five. We examine the association between likelihood of HAP-related health symptom prevalence and characteristics of the microenvironment including: dwelling and cooking area structure; distance to nearest road; and tree cover. We find that children residing in groups of enclosed dwellings, in households that cook indoors, and in households proximate to tree cover, are significantly more likely to experience symptoms of respiratory infection, illness with cough and difficulty breathing. On the other hand, children in households with cemented floors and ventilation holes in the cooking area, are significantly less likely to experience the same symptoms. Our findings suggest that in addition to promoting increased access to clean cooking technologies, there are important infrastructure and microenvironment-related interventions that mitigate HAP exposure.

CT findings in Arnold-Chiari malformation

Energy Technology Data Exchange (ETDEWEB)

Tanaka, Y.; Nakamura, S. (Aichi Prefecture Colony, Kasugai (Japan). Central Hospital); Yamada, H.; Kageyama, N.

1981-12-01

CT scans of Arnold-Chiari malformations demonstrate many abnormal findings that are considered to be specific for this type of malformation. Fifty patients with Arnold-Chiari malformations were studied, and their CT findings were analyzed. This number included 14 preshunted neonatal cases and 36 post-shunted infantile cases. Craniolacunia was recognized only in the neonatal cases, but other skull changes, including scaphocephaly and petrous scalloping, were found more frequently in the infantile cases. The posterior fossa abnormality was composed of several specific changes, such as a non-visualized fourth ventricle, a lateral or upward growth of the cerebellum, or a beaking deformity of the midbrain. These findings were far more common in the infantile cases. However, in 7 neonatal cases on which CT cisternography was performed, these posterior fossa changes were well recognized in the majority of cases. Hydrocephalus was found in all cases. In half of the post-shunted infantile cases, the lateral ventricles were markedly collapsed. Characteristic features of the lateral ventricles, such as a protruding of the caudate nuclei, a pointing of the frontal and/or occipital horns, an absent septum pellucidum, or dominently dilated occipital horns, were commonly found in both neonatal and infantile cases. The subarachnoid space was remarkably widened at the retrothalamic cistern and/or the interhemispheric fissure in many cases.

Image encryption with chaotic map and Arnold transform in the gyrator transform domains

Science.gov (United States)

Sang, Jun; Luo, Hongling; Zhao, Jun; Alam, Mohammad S.; Cai, Bin

2017-05-01

An image encryption method combing chaotic map and Arnold transform in the gyrator transform domains was proposed. Firstly, the original secret image is XOR-ed with a random binary sequence generated by a logistic map. Then, the gyrator transform is performed. Finally, the amplitude and phase of the gyrator transform are permutated by Arnold transform. The decryption procedure is the inverse operation of encryption. The secret keys used in the proposed method include the control parameter and the initial value of the logistic map, the rotation angle of the gyrator transform, and the transform number of the Arnold transform. Therefore, the key space is large, while the key data volume is small. The numerical simulation was conducted to demonstrate the effectiveness of the proposed method and the security analysis was performed in terms of the histogram of the encrypted image, the sensitiveness to the secret keys, decryption upon ciphertext loss, and resistance to the chosen-plaintext attack.

Functional study of the Hap4-like genes suggests that the key regulators of carbon metabolism HAP4 and oxidative stress response YAP1 in yeast diverged from a common ancestor.

Directory of Open Access Journals (Sweden)

Nataliya Petryk

Full Text Available The transcriptional regulator HAP4, induced by respiratory substrates, is involved in the balance between fermentation and respiration in S. cerevisiae. We identified putative orthologues of the Hap4 protein in all ascomycetes, based only on a conserved sixteen amino acid-long motif. In addition to this motif, some of these proteins contain a DNA-binding motif of the bZIP type, while being nonetheless globally highly divergent. The genome of the yeast Hansenula polymorpha contains two HAP4-like genes encoding the protein HpHap4-A which, like ScHap4, is devoid of a bZIP motif, and HpHap4-B which contains it. This species has been chosen for a detailed examination of their respective properties. Based mostly on global gene expression studies performed in the S. cerevisiae HAP4 disruption mutant (ScΔhap4, we show here that HpHap4-A is functionally equivalent to ScHap4, whereas HpHap4-B is not. Moreover HpHAP4-B is able to complement the H2O2 hypersensitivity of the ScYap1 deletant, YAP1 being, in S. cerevisiae, the main regulator of oxidative stress. Finally, a transcriptomic analysis performed in the ScΔyap1 strain overexpressing HpHAP4-B shows that HpHap4-B acts both on oxidative stress response and carbohydrate metabolism in a manner different from both ScYap1 and ScHap4. Deletion of these two genes in their natural host, H. polymorpha, confirms that HpHAP4-A participates in the control of the fermentation/respiration balance, while HpHAP4-B is involved in oxidative stress since its deletion leads to hypersensitivity to H2O2. These data, placed in an evolutionary context, raise new questions concerning the evolution of the HAP4 transcriptional regulation function and suggest that Yap1 and Hap4 have diverged from a unique regulatory protein in the fungal ancestor.

24 CFR 982.607 - Congregate housing: Lease and HAP contract.

Science.gov (United States)

2010-04-01

... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false Congregate housing: Lease and HAP... Types Congregate Housing § 982.607 Congregate housing: Lease and HAP contract. For congregate housing, there is a separate lease and HAP contract for each assisted family. ...

Quantum watermarking scheme through Arnold scrambling and LSB steganography

Science.gov (United States)

Zhou, Ri-Gui; Hu, Wenwen; Fan, Ping

2017-09-01

Based on the NEQR of quantum images, a new quantum gray-scale image watermarking scheme is proposed through Arnold scrambling and least significant bit (LSB) steganography. The sizes of the carrier image and the watermark image are assumed to be 2n× 2n and n× n, respectively. Firstly, a classical n× n sized watermark image with 8-bit gray scale is expanded to a 2n× 2n sized image with 2-bit gray scale. Secondly, through the module of PA-MOD N, the expanded watermark image is scrambled to a meaningless image by the Arnold transform. Then, the expanded scrambled image is embedded into the carrier image by the steganography method of LSB. Finally, the time complexity analysis is given. The simulation experiment results show that our quantum circuit has lower time complexity, and the proposed watermarking scheme is superior to others.

Comparison of Broadband Wireless Access Technology for HAPS Communication

Directory of Open Access Journals (Sweden)

Mingxiang GUAN

2014-03-01

Full Text Available An information system formed by HAP (High Altitude Platform will be a new generation-system for the wireless communications and HAPS (HAP Station communication system combines the advantages of both terrestrial and satellite communication systems and avoids, to different extents, their disadvantages. Third generation (3G mobile technology which is specified by the third generation partnership project (3 GPP is definitely one of the candidates. With the success of wireless network, the IEEE 802.16 standard, with its wireless metropolitan area network (MAN air interface appears to be a strong competitor. We provide initial practical comparison of these two technologies for HAPS Communication.

24 CFR 982.611 - Group home: Lease and HAP contract.

Science.gov (United States)

2010-04-01

... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false Group home: Lease and HAP contract... Types Group Home § 982.611 Group home: Lease and HAP contract. For assistance in a group home, there is a separate HAP contract and lease for each assisted person. ...

24 CFR 982.454 - Termination of HAP contract: Insufficient funding.

Science.gov (United States)

2010-04-01

... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false Termination of HAP contract... Assistance Payments Contract and Owner Responsibility § 982.454 Termination of HAP contract: Insufficient funding. The PHA may terminate the HAP contract if the PHA determines, in accordance with HUD requirements...

24 CFR 982.616 - Shared housing: Lease and HAP contract.

Science.gov (United States)

2010-04-01

... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false Shared housing: Lease and HAP... Types Shared Housing § 982.616 Shared housing: Lease and HAP contract. For assistance in a shared housing unit, there is a separate HAP contract and lease for each assisted family. ...

Difficult intubation in a parturient with syringomyelia and Arnold-Chiari malformation: Use of Airtraq™ laryngoscope

Directory of Open Access Journals (Sweden)

Bensghir Mustapha

2011-01-01

Full Text Available Anesthetic technique in parturient with syringomyelia and Arnold-Chiari malformation is variable depending on the teams. Difficult intubation is one of the risks when general anesthesia is opted. Different devices have been used to manage the difficult intubation in pregnant women. We report the use of Airtraq™ laryngoscope after failed standard laryngoscopy in a parturient with syringomyelia and Arnold-Chiari type I malformation.

Integrated Sensing of Alcohols by CNT Blended HAp Nano Ceramics

Directory of Open Access Journals (Sweden)

Shaikh R. ANJUM

2016-11-01

Full Text Available The research work reports the application of carbon nanotubes (CNT blended Hydroxyapatite (HAp composites as ideal thick film substrates for the detection of hazardous and flammable methanol vapours. The main objective of this work is to improve the temperature-dependent sensitivity of the sensor for the detection of lower methanol concentration. In this study, the sensing ability of native HAp and CNT blended HAp thick films is studied for the detection of methanol vapours present in ambient air individually and in the form of a mixture of methanol, ethanol, and propanol. The sensing parameters are studied using two probe electrical method. The sensor substrate is made by means of doping of different concentrations of CNT in HAp. The sensing of methanol vapours is studied at a fixed concentration of 100 ppm. Native HAp substrate shows good sensitivity for methanol at room temperature; however, its sensing performance is inferior to the CNT blended materials. The blended composites exhibit impressive sensing ability compared with native HAp in terms of sensitivity, response/ recovery time and maximum uptake limit. The sensing mechanism for methanol detection, the role of HAp as a parent material and CNT as an additive, is explained using a suitable sensing mechanism.

HAP1 gene expression is associated with radiosensitivity in breast cancer cells

International Nuclear Information System (INIS)

Wu, Jing; Zhang, Jun-ying; Yin, Li; Wu, Jian-zhong; Guo, Wen-jie; Wu, Jian-feng; Chen, Meng; Xia, You-you; Tang, Jin-hai; Ma, Yong-chao; He, Xia

2015-01-01

Highlights: • Overexpression of HAP1 gene promotes apoptosis in MCF-7 cells after irradiation. • HAP1 reduces tumor volume in nude mice xenograft models after irradiation. • HAP1 increases radiosensitivity of breast cancer cells in vitro and vivo. - Abstract: Objectives: The purpose of this study was to investigate the relationship between huntingtin-associated protein1 (HAP1) gene and radiation therapy of breast cancer cells. Methods: HAP1 gene was transfected into breast cancer MCF-7 cells, which was confirmed by quantitative reverse transcription-polymerase chain reaction analysis (qRT-PCR) and Western blot in vitro. The changes of cell radiosensitivity were assessed by colony formation assay. Apoptosis were examined by flow cytometry. The expressions of two radiation-induced genes were evaluated by Western blot. Tumor growth was investigated in nude mice xenograft models in vivo. Results: Our data showed that HAP1 gene expression was significantly increased in HAP1-transfected MCF-7 cells in comparison with the parental cells or negative control cells. The survival rate in MCF-7/HAP1 cells was significantly decreased after irradiation (0, 2, 4, 6, 8 Gy), compared to cells in MCF-7 and MCF-7/Pb groups in vitro. HAP1 gene increased apoptosis in MCF-7 cells after irradiation. Additionally, the tumor volume and weight in MCF-7/HAP1 + RT group were observably lower than in MCF-7/HAP1 group and MCF-7/Pb + RT group. Conclusion: The present study indicated that HAP1 gene expression was related to the radiosensitivity of breast cancer cells and may play an important role in the regulation of cellular radiosensitivity

Is HAPS Viable for the Next-Generation Telecommunication Platform in Korea?

OpenAIRE

Jonghwa Kim; Deokjoo Lee; Jaekyoung Ahn; Do-Seob Ahn; Bon-Jun Ku

2008-01-01

Abstract HAPS is a promising technology capable of providing broadband multimedia services as an alternative to the satellite communication system or terrestrial network. In this study, economic aspects of HAPS service are analyzed, HAPS services are defined, and revenues from the defined services are forecasted assuming nine scenarios. Capital expenditure as well as operating expenditure is estimated. To evaluate the profitability of HAPS service, the net present value (NPV), payback period,...

Fabrication of CTP/HAp novel gradient composite bioceramics

Institute of Scientific and Technical Information of China (English)

无

2007-01-01

Calcium-titanium-phosphate(CaTi4(PO4)6, CTP)/hydroxyapatite(HAp) is a kind of novel gradient composite bioceramics,which has excellent biocompatibility and bioactivity. CTP ceramic film was synthesized one-step on the surface of titanium using micro-arc oxidation(MAO). The CTP/HAp composite bioceramics were prepared by soaking CTP film in HAp inducing solution for several days. XRD, SEM and EDX were used to characterize the bio-ceramic films phase and composition, morphology and component. The influence of electrolyte molar ratio of Ca to P and the current density to the synthesis of film was studied, and the optimized value of parameters above were 1/6 and 15A/dm2. The parameters of HAp inducing solution, such as component and pH value were also studied and the best pH value which is adjusted by NaOH is 6.4.

Analysis of the fuel influence in obtaining HAp by combustion reaction

International Nuclear Information System (INIS)

Santos, T.L.; Leite, A.M.D.; Viana, K.M.S.

2016-01-01

The search for new materials for biomedical applications has led to investigation of the calcium phosphate bioceramics, and in particular hydroxyapatite (HAp), being a material similar to bone tissue, with excellent biocompatibility and high osteoconduction, enabling bone regeneration which allows the use at implants and prostheses. The synthesis of the nanometric HAp by combustion reaction enables obtaining the nanometric HAp with a more similar structure biological apatite as possible. This work aims to synthesize HAp by combustion reaction using two different routes of synthesis, first, using urea as fuel and the second using glycine, after this, evaluate the influence of fuels used in the microstructure of the hydroxyapatite obtained. The HAp obtained was characterized by: XRD, FTIR and SEM. Through analysis of the results, there is the synthesis conditions used that glycine has performed more favorable to obtaining HAp. (author)

Émile Durkheim between Gabriel Tarde and Arnold van Gennep

DEFF Research Database (Denmark)

Thomassen, Bjørn

2012-01-01

This article will situate Durkheim's work by revisiting two debates that influenced his attempt to define and give direction to sociology and anthropology: the debates between Durkheim and Gabriel Tarde and the debates between Durkheim and Arnold van Gennep. The battle between Tarde and Durkheim...... has in recent years been the object of several conferences and publications. This has happened alongside a much needed Tarde revival in sociology. However, Tarde was only one of Durkheim's opponents. For a long period, following Tarde's death in 1904, Arnold van Gennep represented the strongest...... critique of Durkheim's project. This ‘debate’ is little known among anthropologists and social scientists. The aim of this article is to situate Durkheim and the birth of the social sciences in France between both of these two figures. The aim is therefore also to bring together two disciplinary debates...

Is HAPS Viable for the Next-Generation Telecommunication Platform in Korea?

Directory of Open Access Journals (Sweden)

Jonghwa Kim

2008-07-01

Full Text Available HAPS is a promising technology capable of providing broadband multimedia services as an alternative to the satellite communication system or terrestrial network. In this study, economic aspects of HAPS service are analyzed, HAPS services are defined, and revenues from the defined services are forecasted assuming nine scenarios. Capital expenditure as well as operating expenditure is estimated. To evaluate the profitability of HAPS service, the net present value (NPV, payback period, and the internal rate of return (IRR are calculated. The results show that HAPS is economically justifiable in all the scenarios. Assuming that ARPU for the service is $35 per month in the average scenario, NPV is calculated as $2964 million, IRR becomes 31.9%, and payback occurs in 2017, which implies that HAPS service is profitable in Korea. In addition, the results of the sensitivity analysis show that the results are fairly robust.

Is HAPS Viable for the Next-Generation Telecommunication Platform in Korea?

Directory of Open Access Journals (Sweden)

Lee Deokjoo

2008-01-01

Full Text Available Abstract HAPS is a promising technology capable of providing broadband multimedia services as an alternative to the satellite communication system or terrestrial network. In this study, economic aspects of HAPS service are analyzed, HAPS services are defined, and revenues from the defined services are forecasted assuming nine scenarios. Capital expenditure as well as operating expenditure is estimated. To evaluate the profitability of HAPS service, the net present value (NPV, payback period, and the internal rate of return (IRR are calculated. The results show that HAPS is economically justifiable in all the scenarios. Assuming that ARPU for the service is $35 per month in the average scenario, NPV is calculated as $2964 million, IRR becomes 31.9%, and payback occurs in 2017, which implies that HAPS service is profitable in Korea. In addition, the results of the sensitivity analysis show that the results are fairly robust.

Arnold Rüütel - tshelovek goda!

Index Scriptorium Estoniae

2001-01-01

Saar Polli küsitlusuuringu tulemusel pidas 35% vastanuist aasta inimeseks Arnold Rüütlit. Pealk. ajalehes Molodjozh Estonii (2001) 28. dets.: "Glavnõi tshelovek", lk. 2 ; pealk. ajalehes Narvskaja Gazeta (2001) 28. dets.: "Tshelovekom goda v Estonii stal novõi prezident stranõ", lk. 3 ; pealk. ajalehes Narvskaja Nedelja (2001) 29. dets.: "Titula tshelovek goda zhiteli Estonii udostoili Arnolda Rüütelja i ben Ladena", lk. 3 ; pealk. ajalehes Severnoje Poberezhje (2001) 28. dets.: "Tshelovekom goda stal novõi prezident", lk. 3. Arvamust avaldavad Tiit Sinissaar ja Villu Reiljan

[Optimized isolation and purification of non-typeable Haemophilus influenzae Haps protein].

Science.gov (United States)

Li, Wan-yi; Kuang, Yu; Li, Ming-yuan; Yang, Yuan; Jiang, Zhong-hua; Yao, Feng; Chen, Chang-chun

2007-12-01

To optimize the isolation and purification conditions for Hap(s) protein of non-typeable Haemophilus influenzae. Hap(s) protein was purified by ammonium sulfate precipitation, dialysis desalting and Hitrap weak cation exchange columns of CM Sepharose Fast Flow. The condition of the elution was optimized for pH and ionic strength, the absorbance at 280 nm of the elution samples were detected, and the targeted protein band in the collected samples was observed by SDS-PAGE electrophoresis. The Hitrap ion exchange column was eluted with buffer 1, which resulted in a baseline distribution of absorbance at 280 nm. Buffer 2 elution of the column resulted in the presence of peak absorbance with trails, which was identified to be constituted by some low molecular weight bands by subsequent SDS-PAGE. In serial column elution with buffer 3 with different ionic strength, a peak absorbance was observed with the ionic strength of 100 mmol/L NaCl, and SDS-PAGE confirmed that the peak was generated by the target protein. No obvious peaks or bands in SDS-PAGE occurred with the other ionic strengths. The pH of the buffer only affect the elution of the irrelevant proteins rather than the Hap(s) protein, and elution with the buffer containing 100 mmol/L NaCl can be optimal for eluting the Hap(s) protein.

Anesthesia management for pregnant patient with Arnold-Chiari malformation type I: A case report

Directory of Open Access Journals (Sweden)

Şaban Yalçın

2012-06-01

Full Text Available The Arnold-Chiari I malformation (ACM is a congenitalanomaly characterized by downward herniation of thecerebellar tonsils into the spinal canal. The anomaly maypresent in a variety of ways with vague symptoms suchas head and limb pains, vertigo, hypoesthesia, weaknessin the extremities. Diagnosis is often difficult and thereforedelayed. Measurement of intracranial pressure in thesepatients is an important measure thus precautions shoulbe taken for avoidance of increased intracranial pressure.In this case report, we discussed the anesthetic managementof a pregnant patient with Arnold Chiari I malformationwho underwent an emergency caesarean section.

Adhesion Regulating Molecule 1 Mediates HAP40 Overexpression-Induced Mitochondrial Defects

Science.gov (United States)

Huang, Zih-Ning; Chung, Her Min; Fang, Su-Chiung; Her, Lu-Shiun

2017-01-01

Striatal neuron death in Huntington's disease is associated with abnormal mitochondrial dynamics and functions. However, the mechanisms for this mitochondrial dysregulation remain elusive. Increased accumulation of Huntingtin-associated protein 40 (HAP40) has been shown to be associated with Huntington's disease. However, the link between increased HAP40 and Huntington's disease remains largely unknown. Here we show that HAP40 overexpression causes mitochondrial dysfunction and reduces cell viability in the immortalized mouse striatal neurons. HAP40-associated mitochondrial dysfunction is associated with reduction of adhesion regulating molecule 1 (ADRM1) protein. Consistently, depletion of ADRM1 by shRNAs impaired mitochondrial functions and increased mitochondrial fragmentation in mouse striatal cells. Moreover, reducing ADRM1 levels enhanced activity of fission factor dynamin-related GTPase protein 1 (Drp1) via increased phosphorylation at serine 616 of Drp1 (Drp1Ser616). Restoring ADRM1 protein levels was able to reduce HAP40-induced ROS levels and mitochondrial fragmentation and improved mitochondrial functions and cell viability. Moreover, reducing Drp1 activity by Drp1 inhibitor, Mdivi-1, ameliorates both HAP40 overexpression- and ADRM1 depletion-induced mitochondrial dysfunction. Taken together, our studies suggest that HAP40-mediated reduction of ADRM1 alters the mitochondrial fission activity and results in mitochondrial fragmentation and mitochondrial dysfunction. PMID:29209146

Arnold Rüütel rikkus betoonpaneelidest kai ehitamisega seadust / Oliver Rand

Index Scriptorium Estoniae

Rand, Oliver, 1971-

2007-01-01

Laimjala vallas Saarekülas president Arnold Rüütli omavolilist ehitustegevust kontrollimas käinud keskkonnainspektorid leidsid, et paadisilla rajamiseks oleks president pidanud taotlema erikasutusluba. Ilmunud ka: Meie Maa (2007) 24. aug. 2007, lk. 1

Arnold Rüütel superstar ehk kevadine veinituur Gruusiasse / Raul Ranne

Index Scriptorium Estoniae

Ranne, Raul

2006-01-01

President Arnold Rüütli visiidist Gruusiasse. Vt. samas lk. A14 intervjuud presidendi kaaskonnas olnud suurettevõtja Urmas Sõõrumaaga. Sõõrumaa: "Ma soovitan Gruusiat!". Vabariigi Presidendi ametlik visiit Gruusia Vabariiki 9.-13.05.2006

DETEKSI GEN-GEN PENYANDI FAKTOR VIRULENSI PADA BAKTERI VIBRIO

Directory of Open Access Journals (Sweden)

Ince Ayu Khairani Kadriah

2011-04-01

menggunakan isolat bakteri yang diisolasi dari budidaya udang windu di berbagai daerah di Sulawesi Selatan dan Jawa. Pada penelitian ini digunakan primer spesifik untuk mendeteksi gen-gen virulen toxR gene, hemolysin (vvh gene, dan GyrB gene dengan metode PCR. Dari 35 isolat yang diisolasi, 20 isolat terdeteksi memiliki gen virulensi dan 8 di antaranya memiliki dua gen virulen. Spesies bakteri yang memiliki gen virulen adalah: V.harveyi, V. parahaemolyticus, V. mimicus, dan V. campbelli

President Arnold Rüütel: Eestis on alanud valimiste eelne sisepoliitiline võitlus / Arnold Rüütel ; intervjueerinud Urmo Soonvald

Index Scriptorium Estoniae

Rüütel, Arnold, 1928-

2005-01-01

President Arnold Rüütel vastab küsimustele, mis puudutavad tema kohtumist Venemaa presidendi Vladimir Putiniga, Eesti-Vene piirilepingule allakirjutamist, Läti presidendi Vaira Vike-Freiberga otsust sõita 9. maiks Moskvasse, välisministeeriumiga seotud skandaali, poliitikute selgitusi riigisaladuse ümber tekkinud skandaali kohta, erakorralisi valimisi kui võimalikku lahendust praegusele sisepoliitilisele olukorrale, Eesti välisministri puudumist Brüsselis toimuval kohtumisel USA presidendiga, kohtumist välisministrikandidaat Rein Langiga

Success of Arnol'd's method in hierarchy of ocean models

International Nuclear Information System (INIS)

Ripa, P.

1993-01-01

The method of Arnol'd is used to derive stability conditions of Hamiltonian systems with singular Poisson brackets; notably, those of fluid mechanics. Let the field(s) var-phi(x,t) represent the state variables, and Hamiltonian H [var-phi] and Poisson bracket (.,.) be such that ∂ t var-phi = (var-phi, H). The bracket must have the usual properties; in addition, it may be singular, i.e. there may exist non-trivial functional(s) of state C(var-phi) - called Casimir(s) - such that (C,F) ≡ 0, for any admissible functional of state F(var-phi). Arnol'd's theorms on stability are applied to put constraints on the solutions var-phi(x,t). This model is then applied to the problem of circulation within ocean models, in particular to two families of classical ocean models, primitive equations (PEN) and quasi-geostrophic (QGM) models. These models are layered vertical structures with top and bottom boundaries which may be either rigid or free

Presidendi kantselei tellis Arnold Rüütli büsti / Kadri Paas

Index Scriptorium Estoniae

Paas, Kadri, 1982-

2007-01-01

Presidendi kantselei sõlmis kunstnik Endel Tanilooga 31. oktoobril 2007 lepingu president Arnold Rüütli pronksbüsti tegemiseks. Kuju valmib 2008. a. jaanuaris ja paigutatakse tulevikus kantselei roosiaeda

Positive semidefinite matrix completion, universal rigidity and the Strong Arnold Property

NARCIS (Netherlands)

M. Laurent (Monique); A. Varvitsiotis (Antonios)

2014-01-01

htmlabstractThis paper addresses the following three topics: positive semidefinite (psd) matrix completions, universal rigidity of frameworks, and the Strong Arnold Property (SAP). We show some strong connections among these topics, using semidefinite programming as unifying theme. Our main

Composition of the essential oils of Pinus nigra Arnold from Turkey

OpenAIRE

Turkey, Composition of the essential oils of Pin

2010-01-01

Essential oil composition of the needles of Pinus nigra Arnold collected from different localities in Turkey was investigated by GC and GC/MS. The main components in the oils were a-pinene, b-pinene, b-caryophyllene, and germacrene D.

Composition of the essential oils of Pinus nigra Arnold from Turkey

OpenAIRE

Turkey, Composition of the essential oils of Pin; SEZİK, Ekrem; ÜSTÜN, Osman; DEMİRCİ, Betül; BAŞER, K. Hüsnü Can

2014-01-01

Essential oil composition of the needles of Pinus nigra Arnold collected from different localities in Turkey was investigated by GC and GC/MS. The main components in the oils were a-pinene, b-pinene, b-caryophyllene, and germacrene D.

40 CFR 63.494 - Back-end process provisions-residual organic HAP limitations.

Science.gov (United States)

2010-07-01

... organic HAP limitations. 63.494 Section 63.494 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... § 63.494 Back-end process provisions—residual organic HAP limitations. (a) The monthly weighted average residual organic HAP content of all grades of elastomer processed, measured after the stripping operation...

Positive semidefinite matrix completion, universal rigidity and the Strong Arnold Property

NARCIS (Netherlands)

Laurent, Monique; Varvitsiotis, A.

This paper addresses the following three topics: positive semidefinite (psd) matrix completions, universal rigidity of frameworks, and the Strong Arnold Property (SAP). We show some strong connections among these topics, using semidefinite programming as unifying theme. Our main contribution is a

Olulisim interdistsiplinaarne sündmus anno domini 2004? / Arnold Rüütel

Index Scriptorium Estoniae

Rüütel, Arnold

2004-01-01

President Arnold Rüütel, kultuuriminister Urmas Paet, Tallinna linnapea Tõnis Palts ja Tartu linnapea Laine Jänes vastavad ajalehe Postimees küsimusele mööduva aasta interdistsiplinaarsematest kultuurisündmustest

Assessment of HAPs emissions from advanced power systems

International Nuclear Information System (INIS)

Erickson, T.A.; Brekke, D.W.

1996-01-01

The 1990 Clean Air Act Amendments (CAAA) identified 189 substances as air toxics or hazardous air pollutants (HAPs). Under the CAAA, the U. S. Environmental Protection Agency (EPA) must regulate emissions of these HAPs at their sources, including advanced power systems used for the production of electricity. Eleven trace elements are included in the CAAA list of HAPS, as shown in Table 1. The EPA will define those sources that require regulation and limit their emissions according to regulatory directives. This project focused on evaluating and manipulating the advanced power systems HAPs data currently available for presentation to the U.S. Department of Energy (DOE). Trace components included in the 189 HAPs of the 1990 CAAA are: antimony compounds; arsenic compounds; beryllium compounds; cadmium compounds; chromium compounds; cobalt compounds; lead compounds; manganese compounds; mercury compounds; nickel compounds; and selenium compounds. The review of trace element emissions from advanced power systems and hot-gas cleanup systems included data from Tidd Station, General Electric hot-gas cleanup, Louisiana Gasification Technology Incorporated, and the Cool Water plant. Very few other sources of information were located, and those that were contained significantly flawed information that was not of value to this project. To offset the shortage of information, thermochemical equilibrium predictions were used in evaluating advanced control systems. An outline of the systems reviewed is given in Table 2. In addition to the four demonstration and 1 full-scale systems reviewed, nine conventional systems were also reviewed for comparison with the advanced systems

"To Hell with the Paperwork:" Deciphering the Culture of the Air Commandos

National Research Council Canada - National Science Library

Hoffman, Justin

2008-01-01

The title of this thesis refers to a quote attributed to General "Hap" Arnold as he parted ways with the two commanders of a newly created unit that would soon become designated the 1st Air Commando Group...

24 CFR 982.403 - Terminating HAP contract when unit is too small.

Science.gov (United States)

2010-04-01

... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false Terminating HAP contract when unit... Terminating HAP contract when unit is too small. (a) Violation of HQS space standards. (1) If the PHA... by the family, the PHA must terminate the HAP contract in accordance with its terms. (b) Certificate...

Huntingtin-associated protein-1 (HAP1) regulates endocytosis and interacts with multiple trafficking-related proteins.

Science.gov (United States)

Mackenzie, Kimberly D; Lim, Yoon; Duffield, Michael D; Chataway, Timothy; Zhou, Xin-Fu; Keating, Damien J

2017-07-01

Huntingtin-associated protein 1 (HAP1) was initially identified as a binding partner of huntingtin, mutations in which underlie Huntington's disease. Subcellular localization and protein interaction data indicate that HAP1 may be important in vesicle trafficking, cell signalling and receptor internalization. In this study, a proteomics approach was used for the identification of novel HAP1-interacting partners to attempt to shed light on the physiological function of HAP1. Using affinity chromatography with HAP1-GST protein fragments bound to Sepharose columns, this study identified a number of trafficking-related proteins that bind to HAP1. Interestingly, many of the proteins that were identified by mass spectrometry have trafficking-related functions and include the clathrin light chain B and Sec23A, an ER to Golgi trafficking vesicle coat component. Using co-immunoprecipitation and GST-binding assays the association between HAP1 and clathrin light chain B has been validated in vitro. This study also finds that HAP1 co-localizes with clathrin light chain B. In line with a physiological function of the HAP1-clathrin interaction this study detected a dramatic reduction in vesicle retrieval and endocytosis in adrenal chromaffin cells. Furthermore, through examination of transferrin endocytosis in HAP1 -/- cortical neurons, this study has determined that HAP1 regulates neuronal endocytosis. In this study, the interaction between HAP1 and Sec23A was also validated through endogenous co-immunoprecipitation in rat brain homogenate. Through the identification of novel HAP1 binding partners, many of which have putative trafficking roles, this study provides us with new insights into the mechanisms underlying the important physiological function of HAP1 as an intracellular trafficking protein through its protein-protein interactions. Copyright © 2017 Elsevier Inc. All rights reserved.

Characterization of biomimetically synthesized Hap-Gel nanocomposites as bone substitute

International Nuclear Information System (INIS)

Bera, Tanmay; Vivek, A N; Saraf, S K; Ramachandrarao, P

2008-01-01

There is an increasing demand for an affordable and easy-to-fabricate material to help patients having a long bone gap. In this paper, we describe the biomimetic synthesis of Hap-Gel in situ nanocomposite powders with varied proportions. Their biocompatibility and bone regeneration abilities were assessed on a rabbit model. The use of Hap crystals and Gel molecule, the soluble form of bone protein, makes the nanocomposites comparable to natural bone in constituents. The application of biomimetic principles improves crystal morphology and the interaction of Hap crystals with the Gel molecules as seen through in vitro characterizations. Out of the various compositions studied, one with 80:20 proportions of Hap to Gel proved to be closest to the characteristics of natural bone. The immunological response to this composite, assessed through intradermal inoculation, did not reveal any reaction. The in vivo implantation studies in the femoral condyle of the animals, as assessed by serial post-operative follow-up radiography and the histological evaluation, revealed a good biocompatibility and bone-regeneration ability of the material. Thus, nanocomposites of Hap-Gel have a great potential for serving as an effective and affordable biomaterial for bone grafting applications

Coexistence of Terrestrial and HAP 3G Networks during Disaster Scenarios

Directory of Open Access Journals (Sweden)

P. Pechac

2008-12-01

Full Text Available The aim of this paper is to show the possible coexistence of an HAP and a terrestrial component of 3G networks at a single carrier frequency. The main goal is to compare the basic parameters of terrestrial and HAP com-ponent 3G networks modeled in suburban (macrocell and urban (macro/microcell areas and to demonstrate the way they impact on each other. This study should present what we assume are the better capabilities of HAP 3G networks compared to their terrestrial counterparts. The parameters of the HAP and terrestrial component of 3G networks, were the terrestrial cells to be disabled during disasters, are also presented.

POLLUTION PREVENTION CASE STUDIES: LOW-VOC/HAP WOOD FURNITURE COATINGS

Science.gov (United States)

This article provides a brief profile of the wood furniture industry, discusses pollution prevention activities typically implemented, describes the four low-VOC/HAP coating technologies studied. and summarizes one case study for each of the low-VOC/HAP coating yechnologies inves...

Biochemical Removal of HAP Precursors from Coal

Energy Technology Data Exchange (ETDEWEB)

Olson, Gregory J

1997-05-12

Column biooxidation tests with Kentucky coal confirmed results of earlier shake flask tests showing significant removal from the coal of arsenic, selenium, cobalt, manganese, nickel and cadmium. Rates of pyrite biooxidation in Kentucky coal were only slightly more than half the rates found previously for Indiana and Pittsburgh coals. Removal of pyrite from Pittsburgh coal by ferric ion oxidation slows markedly as ferrous ions accumulate in solution, requiring maintenance of high redox potentials in processes designed for removal of pyrite and hazardous air pollutant (HAP) precursors by circulation of ferric solutions through coal. The pyrite oxidation rates obtained in these tests were used by Unifield Engineering to support the conceptual designs for alternative pyrite and HAP precursor bioleaching processes for the phase 2 pilot plant. Thermophilic microorganisms were tested to determine if mercury could be mobilized from coal under elevated growth temperatures. There was no evidence for mercury removal from coal under these conditions. However, the activity of the organisms may have liberated mercury physically. It is also possible that the organisms dissolved mercury and it readsorbed to the clay preferentially. Both of these possibilities are undergoing further testing. The Idaho National Engineering and Environmental Laboratory's (INEEL) slurry column reactor was operated and several batches of feed coal, product coal, waste solids and leach solutions were submitted to LBL for HAP precursor analysis. Results to date indicate significant removal of mercury, arsenic and other HAP precursors in the combined physical-biological process.

Heteroaryldihydropyrimidine (HAP) and Sulfamoylbenzamide (SBA) Inhibit Hepatitis B Virus Replication by Different Molecular Mechanisms

Science.gov (United States)

Zhou, Zheng; Hu, Taishan; Zhou, Xue; Wildum, Steffen; Garcia-Alcalde, Fernando; Xu, Zhiheng; Wu, Daitze; Mao, Yi; Tian, Xiaojun; Zhou, Yuan; Shen, Fang; Zhang, Zhisen; Tang, Guozhi; Najera, Isabel; Yang, Guang; Shen, Hong C.; Young, John A. T.; Qin, Ning

2017-01-01

Heteroaryldihydropyrimidine (HAP) and sulfamoylbenzamide (SBA) are promising non-nucleos(t)ide HBV replication inhibitors. HAPs are known to promote core protein mis-assembly, but the molecular mechanism of abnormal assembly is still elusive. Likewise, the assembly status of core protein induced by SBA remains unknown. Here we show that SBA, unlike HAP, does not promote core protein mis-assembly. Interestingly, two reference compounds HAP_R01 and SBA_R01 bind to the same pocket at the dimer-dimer interface in the crystal structures of core protein Y132A hexamer. The striking difference lies in a unique hydrophobic subpocket that is occupied by the thiazole group of HAP_R01, but is unperturbed by SBA_R01. Photoaffinity labeling confirms the HAP_R01 binding pose at the dimer-dimer interface on capsid and suggests a new mechanism of HAP-induced mis-assembly. Based on the common features in crystal structures we predict that T33 mutations generate similar susceptibility changes to both compounds. In contrast, mutations at positions in close contact with HAP-specific groups (P25A, P25S, or V124F) only reduce susceptibility to HAP_R01, but not to SBA_R01. Thus, HAP and SBA are likely to have distinctive resistance profiles. Notably, P25S and V124F substitutions exist in low-abundance quasispecies in treatment-naïve patients, suggesting potential clinical relevance. PMID:28205569

40 CFR 63.5340 - How do I determine the allowable HAP loss?

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 12 2010-07-01 2010-07-01 true How do I determine the allowable HAP... Requirements § 63.5340 How do I determine the allowable HAP loss? (a) By the fifteenth of each month, you must determine the allowable HAP loss in pounds from your leather finishing operation for the previous month. (b...

40 CFR 63.5335 - How do I determine the actual HAP loss?

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 12 2010-07-01 2010-07-01 true How do I determine the actual HAP loss... Requirements § 63.5335 How do I determine the actual HAP loss? (a) This section describes the information and procedures you must use to determine the actual HAP loss from your leather finishing operation. By the...

Taxonomic dissection of the genus Micrococcus: Kocuria gen. nov., Nesterenkonia gen. nov., Kytococcus gen. nov., Dermacoccus gen. nov., and Micrococcus Cohn 1872 gen. emend.

Science.gov (United States)

Stackebrandt, E; Koch, C; Gvozdiak, O; Schumann, P

1995-10-01

The results of a phylogenetic and chemotaxonomic analysis of the genus Micrococcus indicated that it is significantly heterogeneous. Except for Micrococcus lylae, no species groups phylogenetically with the type species of the genus, Micrococcus luteus. The other members of the genus form three separate phylogenetic lines which on the basis of chemotaxonomic properties can be assigned to four genera. These genera are the genus Kocuria gen. nov. for Micrococcus roseus, Micrococcus varians, and Micrococcus kristinae, described as Kocuria rosea comb. nov., Kocuria varians comb. nov., and Kocuria kristinae comb. nov., respectively; the genus Nesterenkonia gen. nov. for Micrococcus halobius, described as Nesterenkonia halobia comb. nov.; the genus Nesterenkonia gen. nov. for Micrococcus halobius, described as Nesterenkonia halobia comb. nov.; the genus Dermacoccus gen. nov. for Micrococcus nishinomiyaensis, described as Dermacoccus nishinomiyaensis comb. nov.; and the genus Kytocossus gen. nov. for Micrococcus sedentarius, described as Kytococcus sedentarius comb. nov. M. luteus and M. lylae, which are closely related phylogenetically but differ in some chemotaxonomic properties, are the only species that remain in the genus Micrococcus Cohn 1872. An emended description of the genus Micrococcus is given [corrected].

The HAP Complex Governs Fumonisin Biosynthesis and Maize Kernel Pathogenesis in Fusarium verticillioides.

Science.gov (United States)

Ridenour, John B; Smith, Jonathon E; Bluhm, Burton H

2016-09-01

Contamination of maize ( Zea mays ) with fumonisins produced by the fungus Fusarium verticillioides is a global concern for food safety. Fumonisins are a group of polyketide-derived secondary metabolites linked to esophageal cancer and neural tube birth defects in humans and numerous toxicoses in livestock. Despite the importance of fumonisins in global maize production, the regulation of fumonisin biosynthesis during kernel pathogenesis is poorly understood. The HAP complex is a conserved, heterotrimeric transcriptional regulator that binds the consensus sequence CCAAT to modulate gene expression. Recently, functional characterization of the Hap3 subunit linked the HAP complex to the regulation of secondary metabolism and stalk rot pathogenesis in F. verticillioides . Here, we determine the involvement of HAP3 in fumonisin biosynthesis and kernel pathogenesis. Deletion of HAP3 suppressed fumonisin biosynthesis on both nonviable and live maize kernels and impaired pathogenesis in living kernels. Transcriptional profiling via RNA sequencing indicated that the HAP complex regulates at least 1,223 genes in F. verticillioides , representing nearly 10% of all predicted genes. Disruption of the HAP complex caused the misregulation of biosynthetic gene clusters underlying the production of secondary metabolites, including fusarins. Taken together, these results reveal that the HAP complex is a central regulator of fumonisin biosynthesis and kernel pathogenesis and works as both a positive and negative regulator of secondary metabolism in F. verticillioides .

Rüütel declines May 9 Moscow invitation / Arnold Rüütel

Index Scriptorium Estoniae

Rüütel, Arnold, 1928-

2005-01-01

President Arnold Rüütli avaldus 7. märtsil 2005, milles ta teatab oma otsusest mitte vastu võtta kutset osaleda selle aasta 9. mail Suures Isamaasõjas saavutatud võidu 60. aastapäeva pidustustel Moskvas

Intra- and interpopulation relationships and taxonomic status of Pinus nigra Arnold in Croatia according to morphology and anatomy of needles

Directory of Open Access Journals (Sweden)

Zlatko Liber

2014-01-01

Full Text Available Intra- and interpopulational relationships and taxonomic status of six natural black pine populations (Pinus nigra Arnold from Croatia were analyzed. Special attention in this research was paid to the establishment of taxonomic status and distribution of stenoendemic Dalmatian black pine (Pinus nigra Arnold subsp. dalmatica (Vis. Franco. Three morphological and twenty-one anatomical traits of needles were used as well as analysis by the methods of multivariate statistics. Most of the researched individuals showed strong population affiliation, whereas a clinal transition of morphological and anatomical traits of needles was determined among the populations. The opinion of the existence of three subspecies of black pine on the territory of Republic of Croatia (Pinus nigra Arnold subsp. nigra, Pinus nigra Arnold subsp. dalmatica (Vis. Franco and Pinus nigra Arnold subsp. illyrica (Vid. Fukarek was confirmed. For each of the three subspecies new ranges were represented. Four Croatian populations were included in the stenoendemic subspecies of the Dalmatian black pine (Brač, Hvar, Grobnik and Pelješac, and a new distribution, broken in two, was suggested. Since the Dalmatian black pine has been reduced to several populations only, and there are some signs of continuous diminishing of its range, this research points out the need of making an action plan to preserve all natural populations of this subspecies.

Ando Lepsi sõnavõtt Arnold Rüütli juubelil / Ando Leps

Index Scriptorium Estoniae

Leps, Ando, 1935-

2008-01-01

10. mail 2008 Eesti Rahvusraamatukogu konverentsisaalis Rahvusliku Arengu Fondi ettekandehommikul peetud tervituskõne president Arnold Rüütli 80. sünnipäeva puhul. Kõnes saavad kriitika osaliseks presidendid Konstantin Päts, Lennart Meri ja Toomas Hendrik Ilves

DksA-HapR-RpoS axis regulates haemagglutinin protease production in Vibrio cholerae.

Science.gov (United States)

Basu, Pallabi; Pal, Ritesh Ranjan; Dasgupta, Shreya; Bhadra, Rupak K

2017-06-01

DksA acts as a co-factor for the intracellular small signalling molecule ppGpp during the stringent response. We recently reported that the expression of the haemagglutinin protease (HAP), which is needed for shedding of the cholera pathogen Vibrio cholerae during the late phase of infection, is significantly downregulated in V. cholerae ∆dksA mutant (∆dksAVc) cells. So far, it has been shown that HAP production by V. cholerae cells is critically regulated by HapR and also by RpoS. Here, we provide evidence that V. cholerae DksA (DksAVc) positively regulates HapR at both the transcriptional and post-transcriptional levels. We show that in ∆dksAVc cells the CsrB/C/D sRNAs, required for the maintenance of intracellular levels of hapR transcripts during the stationary growth, are distinctly downregulated. Moreover, the expression of exponential phase regulatory protein Fis, a known negative regulator of HapR, was found to continue even during the stationary phase in ∆dksAVc cells compared to that of wild-type strain, suggesting another layer of complex regulation of HapR by DksAVc. Extensive reporter construct-based and quantitative reverse-transcriptase PCR (qRT-PCR) analyses supported that RpoS is distinctly downregulated at the post-transcriptional/translational levels in stationary phase-grown ∆dksAVc cells. Since HAP expression through HapR and RpoS is stationary phase-specific in V. cholerae, it appears that DksAVc is also a critical stationary phase regulator for fine tuning of the expression of HAP. Moreover, experimental evidence provided in this study clearly supports that DksAVc is sitting at the top of the hierarchy of regulation of expression of HAP in V. cholerae.

40 CFR Table 3 to Subpart Ggg of... - Soluble HAP

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 11 2010-07-01 2010-07-01 true Soluble HAP 3 Table 3 to Subpart GGG of Part 63 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED... HAP Compound 1,1-Dimethylhydrazine. 1,4-Dioxane. Acetonitrile. Acetophenone. Diethyl sulfate. Dimethyl...

Translation of the V. I. Arnold paper "From Superpositions to KAM Theory" (Vladimir Igorevich Arnold. Selected — 60, Moscow: PHASIS, 1997, pp. 727-740)

Science.gov (United States)

Sevryuk, Mikhail B.

2014-11-01

V. I. Arnold (12 June 1937-3 June 2010) published several papers where he described, in the form of recollections, his two earliest research problems (superpositions of continuous functions and quasi-periodic motions in dynamical systems), the main results and their interrelations: [A1], then [A2] (reprinted as [A4, A6]), and [A3] (translated into English by the author as [A5]). The first exposition [A1] has never been translated into English; however, it contains many details absent in the subsequent articles. It seems therefore that publishing the English translation of the paper [A1] would not be superfluous. What follows is this translation. In many cases, the translator gives complete bibliographic descriptions of various papers mentioned briefly in the original Russian text. The English translations of papers in Russian are also pointed out where possible. A related material is contained also in Arnold's recollections "On A.N. Kolmogorov". Slightly different versions of these reminiscences were published several times in Russian and English [A7-A12]. The early history of KAM theory is also discussed in detail in the recent brilliant semi-popular book [A13].

Effect of ultrasound irradiation on the production of nHAp/MWCNT nanocomposites

Energy Technology Data Exchange (ETDEWEB)

Lobo, Anderson O., E-mail: aolobo@univap.br [Laboratory of Biomedical Nanotechnology, Development Research Institute (IP and D), Universidade do Vale do Paraiba (Univap), Av. ShishimaHifumi, 2911, São José dos Campos, 12244-000 SP (Brazil); Zanin, Hudson [Associated Laboratory for Sensors and Materials (LAS), National Institute for Space Research (INPE), Av. dos Astronautas 1758, São José dos Campos, 12227-010 SP (Brazil); Siqueira, Idalia A.W.B.; Leite, Nelly C.S.; Marciano, Fernanda R. [Laboratory of Biomedical Nanotechnology, Development Research Institute (IP and D), Universidade do Vale do Paraiba (Univap), Av. ShishimaHifumi, 2911, São José dos Campos, 12244-000 SP (Brazil); Corat, Evaldo J. [Associated Laboratory for Sensors and Materials (LAS), National Institute for Space Research (INPE), Av. dos Astronautas 1758, São José dos Campos, 12227-010 SP (Brazil)

2013-10-15

Large amounts of nanohydroxyapatite (nHAp)-multiwall carbon nanotube (MWCNT) nanocomposites are produced by two different aqueous precipitation methods. The ultrasonic irradiation (UI) and slow-drip addition under continuous magnetic stirring (DMS) methods were used to investigate the precipitation of nHAp acicular crystals. Calcium-nitrate, diammonium hydrogen phosphate, and ammonium hydroxide were used as precursor reagents. Superhydrophilic MWCNT were also employed. XPS analysis evidences that the functionalized MWCNTs are composed of 18 to 20 at.% of oxygen and that this property influences the nHAp formation. The high surface area of the MWCNT decreases the mean free path of ions, favoring the nHAp formation assisted by UI. The crystallinity was evaluated using the Scherrer equation. Semi-qualitative energy dispersive spectroscopy (EDS) analysis showed that the main components of HAp powders were calcium and phosphorus in the ratio Ca/P around of 1.67. Bioactivity properties of the nHAp/MWCNT-UI nanocomposites could be evaluated after 14 days soaking in simulated body fluid medium. Scanning electron microscopy, EDS, Fourier transform infrared attenuated total reflection spectroscopy, and X-ray diffraction techniques proved that the apatites formed on the surface and to points that the nHAp/MWCNT-UI have potential biological applications. - Highlights: • Nanohydroxyapatite/multiwalled carbon nanotube nanocomposites were produced via aqueous precipitation. • Two methodologies were compared, such as: dropwise and ultrasound irradiation (UI). • Analysis found strong connections between UI and the crystallization process.

iHAP – integrated haplotype analysis pipeline for characterizing the haplotype structure of genes

Directory of Open Access Journals (Sweden)

Lim Yun Ping

2006-12-01

Full Text Available Abstract Background The advent of genotype data from large-scale efforts that catalog the genetic variants of different populations have given rise to new avenues for multifactorial disease association studies. Recent work shows that genotype data from the International HapMap Project have a high degree of transferability to the wider population. This implies that the design of genotyping studies on local populations may be facilitated through inferences drawn from information contained in HapMap populations. Results To facilitate analysis of HapMap data for characterizing the haplotype structure of genes or any chromosomal regions, we have developed an integrated web-based resource, iHAP. In addition to incorporating genotype and haplotype data from the International HapMap Project and gene information from the UCSC Genome Browser Database, iHAP also provides capabilities for inferring haplotype blocks and selecting tag SNPs that are representative of haplotype patterns. These include block partitioning algorithms, block definitions, tag SNP definitions, as well as SNPs to be "force included" as tags. Based on the parameters defined at the input stage, iHAP performs on-the-fly analysis and displays the result graphically as a webpage. To facilitate analysis, intermediate and final result files can be downloaded. Conclusion The iHAP resource, available at http://ihap.bii.a-star.edu.sg, provides a convenient yet flexible approach for the user community to analyze HapMap data and identify candidate targets for genotyping studies.

Arnold Rüütel saab kõrgeima autasu / Silja Lättemäe

Index Scriptorium Estoniae

Lättemäe, Silja, 1952-

2008-01-01

President Arnold Rüütel saab president Toomas Hendrik Ilveselt Riigivapi ketiklassi teenetemärgi. Rahvaliit pole rahul, et A. Rüütel pole saanud ühtki riiklikku autasu oma panuse eest Eesti taasiseseisvumisse

24 CFR 983.206 - HAP contract amendments (to add or substitute contract units).

Science.gov (United States)

2010-04-01

... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false HAP contract amendments (to add or... Contract § 983.206 HAP contract amendments (to add or substitute contract units). (a) Amendment to substitute contract units. At the discretion of the PHA and subject to all PBV requirements, the HAP contract...

Deletion of HAPS_2096 Increases Sensitivity to Cecropin B in Haemophilus parasuis.

Science.gov (United States)

Chen, Fanjie; Hu, Han; Li, Zhonghua; Huang, Jiacheng; Cai, Xuwang; Wang, Chunmei; He, Qigai; Cao, Jiyue

2015-01-01

Cecropin B (CB) is a very effective natural antimicrobial peptide that has shown great potential for future antimicrobial drug development. HAPS_2096 is a Haemophilus parasuis gene that encodes the periplasmic substrate-binding protein of an ATP-binding cassette-type amino acid transporter. In this research, we constructed and verified an HAPS_2096 deletion mutant and a complementary HAPS_2096 mutant of H. parasuis JS0135. A bactericidal assay revealed that the HAPS_2096 deletion mutant was significantly more sensitive than the wild-type strain to 0.25-0.5 µg/ml CB. However, the gene complementation alleviated the CB sensitivity of the mutant. Immunoelectron microscopy observation following a 30-min treatment with a sublethal concentration of CB (0.25 μg/ml) revealed more extensive morphological damage in the mutant strain than in the wild-type strain. Hence, our results suggest that the HAPS_2096 gene contributes to H. parasuis resistance to CB. © 2015 S. Karger AG, Basel.

Navigation and Positioning System Using High Altitude Platforms Systems (HAPS)

Science.gov (United States)

Tsujii, Toshiaki; Harigae, Masatoshi; Harada, Masashi

Recently, some countries have begun conducting feasibility studies and R&D projects on High Altitude Platform Systems (HAPS). Japan has been investigating the use of an airship system that will function as a stratospheric platform for applications such as environmental monitoring, communications and broadcasting. If pseudolites were mounted on the airships, their GPS-like signals would be stable augmentations that would improve the accuracy, availability, and integrity of GPS-based positioning systems. Also, the sufficient number of HAPS can function as a positioning system independent of GPS. In this paper, a system design of the HAPS-based positioning system and its positioning error analyses are described.

40 CFR Table 1 to Subpart Nnnnnn... - HAP Emissions Sources

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 14 2010-07-01 2010-07-01 false HAP Emissions Sources 1 Table 1 to Subpart NNNNNN of Part 63 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR...: Chromium Compounds Pt. 63, Subpt. NNNNNN, Table 1 Table 1 to Subpart NNNNNN of Part 63—HAP Emissions...

[Demise of the wound physician vocation exemplified by the political representative Arnold Schlegel (1850-1924)].

Science.gov (United States)

Gross, D

1996-01-01

The name of Arnold Schlegel stands for a dazzling and complex personality. After being apprenticed to a barber surgeon in Württemberg, he spent about four decades in Switzerland working as an innkeeper. Yet, Schlegel distinguished himself as one of the leading representatives of the last non-academic surgeons in Württemberg. In contrast to most of his surgical colleagues, most of Schlegel's vocational activities are documented. This study is based on unpublished documents of different archives of Württemberg and Switzerland. The aim of the study is to illuminate the life of Arnold Schlegel and, in view of his policy, to illustrate the trying circumstances of contemporary barber surgery.

40 CFR 63.1298 - Standards for slabstock flexible polyurethane foam production-HAP emissions from equipment cleaning.

Science.gov (United States)

2010-07-01

... polyurethane foam production-HAP emissions from equipment cleaning. 63.1298 Section 63.1298 Protection of... foam production—HAP emissions from equipment cleaning. Each owner or operator of a new or existing...(a)(1) shall not use a HAP or a HAP-based material as an equipment cleaner. ...

Geographical affinities of the HapMap samples.

Directory of Open Access Journals (Sweden)

Miao He

Full Text Available The HapMap samples were collected for medical-genetic studies, but are also widely used in population-genetic and evolutionary investigations. Yet the ascertainment of the samples differs from most population-genetic studies which collect individuals who live in the same local region as their ancestors. What effects could this non-standard ascertainment have on the interpretation of HapMap results?We compared the HapMap samples with more conventionally-ascertained samples used in population- and forensic-genetic studies, including the HGDP-CEPH panel, making use of published genome-wide autosomal SNP data and Y-STR haplotypes, as well as producing new Y-STR data. We found that the HapMap samples were representative of their broad geographical regions of ancestry according to all tests applied. The YRI and JPT were indistinguishable from independent samples of Yoruba and Japanese in all ways investigated. However, both the CHB and the CEU were distinguishable from all other HGDP-CEPH populations with autosomal markers, and both showed Y-STR similarities to unusually large numbers of populations, perhaps reflecting their admixed origins.The CHB and JPT are readily distinguished from one another with both autosomal and Y-chromosomal markers, and results obtained after combining them into a single sample should be interpreted with caution. The CEU are better described as being of Western European ancestry than of Northern European ancestry as often reported. Both the CHB and CEU show subtle but detectable signs of admixture. Thus the YRI and JPT samples are well-suited to standard population-genetic studies, but the CHB and CEU less so.

Arnold Hauser e a literatura espanhola

Directory of Open Access Journals (Sweden)

Mario M. González

2010-01-01

Full Text Available The reading of Arnold Hauser´s work, in particular his book Der Manierismus, written in 1964, that deals with Spanish literature, allows us to overcome the usual classifications found in manuals of this area based only on chronological data. Hauser calls "Mannerism" the crisis of the Renaissance, distinguishing it from European Baroque movements. Some of the Spanish authors and their works from the sixteenth and seventeenth centuries respond to the characteristics of Mannerism, if one takes into account their perspectivism, the presence of paradox, their cerebral construction, the discovery of the modern reader, their autonomy as literary works, the overcoming of the classical genders, the use of dialog, etc, and can, therefore, be seen as the basis of the literary Modernity.

Kõrgeid ja inimlikke sihte / Arnold Rüütel

Index Scriptorium Estoniae

Rüütel, Arnold, 1928-

2006-01-01

Eesti Päevaleht lüh. Ilmunud ka: Postimees : na russkom jazõke 3. jaan. lk. 7; Pärnu Postimees 3. jaan. lk. 11; Virumaa Teataja 3. jaan. lk. 11; Järva Teataja 3. jaan. lk. 7; Võrumaa Teataja 3. jaan. lk. 2; Põhjarannik 3. jaan. lk. 2; Severnoje Poberezhje 3. jaan. lk. 2; Meie Maa 3. jaan. lk. 2; Hiiu Leht 3. jaan. lk. 2; Eesti Päevaleht 3. jaan. lk. 2; Maaleht 5. jaan. lk. 6, Lääne-Harju Ekspress 7. jaan. lk. 3. President Arnold Rüütli uusaastaläkitus

Siringomielia y malformación de Arnold-Chiari

Directory of Open Access Journals (Sweden)

Jairo Muñoz Escobar

1971-01-01

Full Text Available Presentamos en este informe, nuestra experiencia en ocho casos de siringomielia en dos de ellos asociada a malformación de Arnold Chiari, que hemos analizado desde el punto de vista clínico y de los hallazgos de radiología simple y contrastada. Analizamos igualmente las técnicas quirúrgicas empleadas y los resultados obtenidos en siete casos que fueron intervenidos quirúrgicamente. Finalmente comparamos nuestros hallazgos y resultados con los mencionados en la literatura y hacemos algunos comentarios sobre fisio-patología.

HAPS Gateway Link in the 5850-7075 MHz and Coexistence with Fixed Satellite Service

Directory of Open Access Journals (Sweden)

M. Ahmed

2013-09-01

Full Text Available Gateway link is essential to connect HAPS platform to terrestrial based networks. This crucial link is incorporated in HAPS fixed service spectrum allocation in considerably high frequencies, renders the link for more attenuations by atmospheric gases, and rain effects, especially when the regional climate is not favorable. However, under the agenda item 1.20 of World Radio Conference-2012 (WRC-12 new HAPS allocation in the 5850-7075 MHz band is proposed. Although, spectrum features are incomparably reliable, on the contrary, Fixed Satellite Service (FSS uplink transmissions will have signal levels much higher than those in HAPS systems and have the potential for causing interference at the HAPS gateway receiver. In this article a key aspect of co-channel interference phenomena is investigated to facilitate optimum frequency sharing in the band in question. By proposing mitigation techniques and statistical method this generic prediction model enhances the capability of the HAPS spectrum sharing and provides flexibility in spectrum planning for different fixed services.

A Chaotic Cryptosystem for Images Based on Henon and Arnold Cat Map

Science.gov (United States)

Sundararajan, Elankovan

2014-01-01

The rapid evolution of imaging and communication technologies has transformed images into a widespread data type. Different types of data, such as personal medical information, official correspondence, or governmental and military documents, are saved and transmitted in the form of images over public networks. Hence, a fast and secure cryptosystem is needed for high-resolution images. In this paper, a novel encryption scheme is presented for securing images based on Arnold cat and Henon chaotic maps. The scheme uses Arnold cat map for bit- and pixel-level permutations on plain and secret images, while Henon map creates secret images and specific parameters for the permutations. Both the encryption and decryption processes are explained, formulated, and graphically presented. The results of security analysis of five different images demonstrate the strength of the proposed cryptosystem against statistical, brute force and differential attacks. The evaluated running time for both encryption and decryption processes guarantee that the cryptosystem can work effectively in real-time applications. PMID:25258724

Arnold Rüütel : kui lapsi ei sünni, kes siis Eesti ühiskonnas väärtusi loob? / Arnold Rüütel ; intervjueerinud Kärt Karpa

Index Scriptorium Estoniae

Rüütel, Arnold, 1928-

2007-01-01

President Arnold Rüütel vastab küsimustele, mis puudutavad tema praegust tegevust, Eestis taasiseseisvumise järel tehtud vigu, maapiirkondade kõrvalejäämist, Eesti poliitika ideoloogia muutumist taasiseseisvumisest alates, suhtumist ülemnõukogu saadikuisse, pronksööd, Rahvaliitu, suhtumist Rahvaliidu ja SDE võimalikku ühinemisse

GenBank

OpenAIRE

Benson, Dennis A.; Karsch-Mizrachi, Ilene; Lipman, David J.; Ostell, James; Rapp, Barbara A.; Wheeler, David L.

2002-01-01

The GenBank sequence database incorporates publicly available DNA sequences of more than 105 000 different organisms, primarily through direct submission of sequence data from individual laboratories and large-scale sequencing projects. Most submissions are made using the BankIt (web) or Sequin programs and accession numbers are assigned by GenBank staff upon receipt. Data exchange with the EMBL Data Library and the DNA Data Bank of Japan helps ensure comprehensive worldwide coverage. GenBank...

President Rüütel's speech at UN / Arnold Rüütel

Index Scriptorium Estoniae

Rüütel, Arnold

2004-01-01

President Arnold Rüütli 22. septembril New Yorgis ÜRO peaassamblee 59. istungjärgu peadebatil peetud kõne, milles ta keskendus ÜRO aastatuhande deklaratsioonis sõnastatud eesmärkide täitmise ja digitaalse lõhe ületamise võimalustele ning põlisrahvaste õiguste kaitsele. Töövisiit New Yorki 19.-24.09.2004

In situ remediation and phytotoxicity assessment of lead-contaminated soil by biochar-supported nHAP.

Science.gov (United States)

Yang, Zhangmei; Fang, Zhanqiang; Tsang, Pokeung Eric; Fang, Jianzhang; Zhao, Dongye

2016-11-01

In this study, a kind of biochar-supported nano-hydroxyapatite (nHAP@BC) material was used in in-situ remediation of lead-contaminated soil. Column experiments were performed to compare the mobility of nHAP@BC and Bare-nHAP. The immobilization, accumulation and toxic effects of Pb in the after-amended soil were assessed by the in vitro toxicity tests and pot experiments. The column experiments showed a significant improvement in the mobility of nHAP@BC. The immobilization rate of Pb in the soil was 74.8% after nHAP@BC remediation. Sequential extraction procedures revealed that the residual fraction of Pb increased by 66.6% after nHAP@BC remediation, which greatly reduced the bioavailability of Pb in the soil. In addition, pot experiments indicated that nHAP@BC could effectively reduce the upward translocation capacity of Pb in a soil-plant system. The concentration of Pb in the aerial part of the cabbage mustard was 0.1 mg/kg, which is lower than the tolerance limit (0.3 mg/kg). nHAP@BC can remediate Pb-contaminated soil effectively, which can restore soil quality for planting. Copyright © 2016 Elsevier Ltd. All rights reserved.

GenBank

Data.gov (United States)

U.S. Department of Health & Human Services — GenBank is the NIH genetic sequence database, an annotated collection of all publicly available DNA sequences. GenBank is designed to provide and encourage access...

Hazardous air pollutant (HAP) emission characterization of sewage treatment facilities in Korea.

Science.gov (United States)

Kang, Kyoung-Hee; Dong, Jong-In

2010-04-01

Until recently, nearly all sewage treatment-related regulations and researches have focused on the removal of the conventional and toxic pollutants from liquid effluents. The discharge of toxic compounds to the atmosphere has been implicitly regarded as a way of removal or destruction. During sewage treatment, the fate mechanism of volatilization/stripping, sorption and biotransformation primarily determines the fate of volatile HAPs. The objectives of this study are to investigate the emission characteristics of HAPs, which are generated from the liquid surface of sewage treatment facilities, by using an emission isolation flux chamber. HAP emissions increased at the inlet of the aerobic chamber during summer due to the relatively high atmospheric temperature. The percent ratio of flux for toluene reached its peak in winter, accounting for 33.6-34.2% of the total, but decreased to 25.1-28.6% in summer. In autumn, trichloroethene (TCE) was the highest, recording 17.6-18.1%, with chloroform and toluene showing similar levels. It seems that the ratio of chlorinated hydrocarbons increases in both summer and autumn because the chamber temperature during that time is higher than winter. This study is the initial study to investigate the emission characteristics of volatile HAPs emitted from domestic sewage treatment facilities to the air in Korea. Therefore, the isolation flux chamber will be used as an emission estimations tool to measure HAPs from sewage treatment facilities and may be applied to develop the emission factor and national source inventory of HAPs.

In vitro and in vivo tests of PLA/d-HAp nanocomposite

Science.gov (United States)

Thom Nguyen, Thi; Hoang, Thai; Mao Can, Van; Son Ho, Anh; Hai Nguyen, Song; Thu Trang Nguyen, Thi; Pham, Thi Nam; Phuong Nguyen, Thu; Le Hien Nguyen, Thi; Thanh Dinh Thi, Mai

2017-12-01

The bioactivity of the PLA/d-HAp nanocomposite with 30 wt.% d-HAp was evaluated by in vitro tests and indicated that after 7 immersion days in SBF solution, PLA amorphous part was hydrolyzed and PLA crystal part was remained. The formation of apatite on the surface of the material was observed. The in vivo test results of PLA/d-HAp nanocomposite (70/30 wt/wt) on femur of dogs displayed that 3 months after grafting, the materials did not induce any osteitis, osteomyelitis or structural abnormalities. The histological and x-ray image demonstrated a growth of the bone into the material area, while osteitis and osteomyelitis were not observed.

Diversity Performance Analysis on Multiple HAP Networks

Science.gov (United States)

Dong, Feihong; Li, Min; Gong, Xiangwu; Li, Hongjun; Gao, Fengyue

2015-01-01

One of the main design challenges in wireless sensor networks (WSNs) is achieving a high-data-rate transmission for individual sensor devices. The high altitude platform (HAP) is an important communication relay platform for WSNs and next-generation wireless networks. Multiple-input multiple-output (MIMO) techniques provide the diversity and multiplexing gain, which can improve the network performance effectively. In this paper, a virtual MIMO (V-MIMO) model is proposed by networking multiple HAPs with the concept of multiple assets in view (MAV). In a shadowed Rician fading channel, the diversity performance is investigated. The probability density function (PDF) and cumulative distribution function (CDF) of the received signal-to-noise ratio (SNR) are derived. In addition, the average symbol error rate (ASER) with BPSK and QPSK is given for the V-MIMO model. The system capacity is studied for both perfect channel state information (CSI) and unknown CSI individually. The ergodic capacity with various SNR and Rician factors for different network configurations is also analyzed. The simulation results validate the effectiveness of the performance analysis. It is shown that the performance of the HAPs network in WSNs can be significantly improved by utilizing the MAV to achieve overlapping coverage, with the help of the V-MIMO techniques. PMID:26134102

Diversity Performance Analysis on Multiple HAP Networks

Directory of Open Access Journals (Sweden)

Feihong Dong

2015-06-01

Full Text Available One of the main design challenges in wireless sensor networks (WSNs is achieving a high-data-rate transmission for individual sensor devices. The high altitude platform (HAP is an important communication relay platform for WSNs and next-generation wireless networks. Multiple-input multiple-output (MIMO techniques provide the diversity and multiplexing gain, which can improve the network performance effectively. In this paper, a virtual MIMO (V-MIMO model is proposed by networking multiple HAPs with the concept of multiple assets in view (MAV. In a shadowed Rician fading channel, the diversity performance is investigated. The probability density function (PDF and cumulative distribution function (CDF of the received signal-to-noise ratio (SNR are derived. In addition, the average symbol error rate (ASER with BPSK and QPSK is given for the V-MIMO model. The system capacity is studied for both perfect channel state information (CSI and unknown CSI individually. The ergodic capacity with various SNR and Rician factors for different network configurations is also analyzed. The simulation results validate the effectiveness of the performance analysis. It is shown that the performance of the HAPs network in WSNs can be significantly improved by utilizing the MAV to achieve overlapping coverage, with the help of the V-MIMO techniques.

Spectral decomposition of the stretching dynamics of the Arnold cat map

International Nuclear Information System (INIS)

Hasegawa, Hiroshi H.; Driebe, Dean J.; Li, C.-B.

2003-01-01

Using the Markov partition of the Arnold cat map on the covering space allows for the introduction of a stable basis in which the Frobenius-Perron operator may be decomposed. We consider in detail the stretching dynamics on the partition of the transformation that yields the cat map under two iterations. The discrete decay modes of the system are constructed

40 CFR 63.5390 - How do I measure the HAP content of a finish?

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 12 2010-07-01 2010-07-01 true How do I measure the HAP content of a... Initial Compliance Requirements § 63.5390 How do I measure the HAP content of a finish? (a) To determine the HAP content of a finish, the reference method is EPA Method 311 of appendix A of 40 CFR part 63...

Eestit peab esindama Moskvas valitsuse liige / Arnold Rüütel

Index Scriptorium Estoniae

Rüütel, Arnold

2005-01-01

Ilmunud ka Järva Teataja (2005/Mar/8) lk. 2 ; Põhjarannik (2005/Mar/8) lk. 2 ; Severnoje Poberezhje (2005/Mar/8) lk. 2 ; Vooremaa (2005/Mar/10) lk. 2 ; Harjumaa (2005/Mar/11) lk. 2. President Arnold Rüütli avaldus 7. märtsil 2005, milles ta teatab oma otsusest mitte vastu võtta kutset osaleda selle aasta 9. mail Suures Isamaasõjas saavutatud võidu 60. aastapäeva pidustustel Moskvas

Arnold Rüütel vassis taas aastaarvuga / Anneli Ammas

Index Scriptorium Estoniae

Ammas, Anneli, 1962-

2006-01-01

President Arnold Rüütel väitis 31. augusti Eesti Päevalehes, et temast sai kommunistlik noor 1949. aastal, autori sõnul algas A. Rüütli liikmelisus ELKNÜ-s juba 1946. aastal. Lähiajaloo uurija Meelis Maripuu väitel ei olnud 1946. aastal ELKNÜ veel massiorganisatsioon. Vt. samas: Varasem intervjuu - see oli 1949, pärast küüditamist; Rüütel: ma pole midagi salanud ; Ilves: Eesti vajab iga inimest. Toomas Hendrik Ilvese avaldusest seoses Johannes Hindi kohtuasja käsitlemisega ajakirjanduses

Eesti esinaivisti 100. sünniaastapäev / Tiiu Männiste

Index Scriptorium Estoniae

Männiste, Tiiu, 1959-

2000-01-01

Paul Kondase 100. sünniaastapäeva puhul tema maalide näitus Viljandi kunstisaalis. Avamisel demonstreeris Mark Soosaar oma filmi "Pühapäevamaalijad". Kilpkonna galeriis näitusel "Veel naiviste" Joan (?Joann) Sõstra (1913-1992) (puuskulptuurid), Osvald Raba (1909-1996) ja Arnold Vihmandi (1912) looming.

Arnold tongues and the Devil's Staircase in a discrete-time Hindmarsh–Rose neuron model

International Nuclear Information System (INIS)

Felicio, Carolini C.; Rech, Paulo C.

2015-01-01

We investigate a three-dimensional discrete-time dynamical system, described by a three-dimensional map derived from a continuous-time Hindmarsh–Rose neuron model by the forward Euler method. For a fixed integration step size, we report a two-dimensional parameter-space for this system, where periodic structures, the so-called Arnold tongues, can be seen with periods organized in a Farey tree sequence. We also report possible modifications in this parameter-space, as a function of the integration step size. - Highlights: • We investigate the parameter-space of a particular 3D map. • Periodic structures, namely Arnold tongues, can be seen there. • They are organized in a Farey tree sequence. • The map was derived from a continuous-time Hindmarsh–Rose neuron model. • The forward Euler method was used for such purpose.

40 CFR Table 8 to Subpart Wwww of... - Initial Compliance With Organic HAP Emissions Limits

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 12 2010-07-01 2010-07-01 true Initial Compliance With Organic HAP... Organic HAP Emissions Limits As specified in § 63.5860(a), you must demonstrate initial compliance with organic HAP emissions limits as specified in the following table: For . . . That must meet the following...

40 CFR 63.1296 - Standards for slabstock flexible polyurethane foam production-HAP ABA equipment leaks.

Science.gov (United States)

2010-07-01

... polyurethane foam production-HAP ABA equipment leaks. 63.1296 Section 63.1296 Protection of Environment... production—HAP ABA equipment leaks. Each owner or operator of a new or existing slabstock affected source complying with the emission point specific limitation option provided in § 63.1293(a) shall control HAP ABA...

40 CFR 63.1295 - Standards for slabstock flexible polyurethane foam production-HAP ABA storage vessels.

Science.gov (United States)

2010-07-01

... polyurethane foam production-HAP ABA storage vessels. 63.1295 Section 63.1295 Protection of Environment... production—HAP ABA storage vessels. Each owner or operator of a new or existing slabstock affected source complying with the emission point specific limitation option provided in § 63.1293(a) shall control HAP ABA...

Vladimir I. Arnold collected works : hydrodynamics, bifurcation theory, algebraic geometry : 1965-1972

CERN Document Server

Arnold, Vladimir I; Khesin, Boris; Marsden, Jerrold E; Varchenko, AN; Vassiliev, Victor A; Viro, Oleg Yanovich; Zakalyukin, Vladimir

2013-01-01

Vladimir Arnold was one of the great mathematical scientists of our time. He is famous for both the breadth and the depth of his work. At the same time he is one of the most prolific and outstanding mathematical authors. This second volume of his ""Collected Works"" focuses on hydrodynamics, bifurcation theory, and algebraic geometry.

SimHap GUI: an intuitive graphical user interface for genetic association analysis.

Science.gov (United States)

Carter, Kim W; McCaskie, Pamela A; Palmer, Lyle J

2008-12-25

Researchers wishing to conduct genetic association analysis involving single nucleotide polymorphisms (SNPs) or haplotypes are often confronted with the lack of user-friendly graphical analysis tools, requiring sophisticated statistical and informatics expertise to perform relatively straightforward tasks. Tools, such as the SimHap package for the R statistics language, provide the necessary statistical operations to conduct sophisticated genetic analysis, but lacks a graphical user interface that allows anyone but a professional statistician to effectively utilise the tool. We have developed SimHap GUI, a cross-platform integrated graphical analysis tool for conducting epidemiological, single SNP and haplotype-based association analysis. SimHap GUI features a novel workflow interface that guides the user through each logical step of the analysis process, making it accessible to both novice and advanced users. This tool provides a seamless interface to the SimHap R package, while providing enhanced functionality such as sophisticated data checking, automated data conversion, and real-time estimations of haplotype simulation progress. SimHap GUI provides a novel, easy-to-use, cross-platform solution for conducting a range of genetic and non-genetic association analyses. This provides a free alternative to commercial statistics packages that is specifically designed for genetic association analysis.

HapX positively and negatively regulates the transcriptional response to iron deprivation in Cryptococcus neoformans.

Directory of Open Access Journals (Sweden)

Won Hee Jung

2010-11-01

Full Text Available The fungal pathogen Cryptococcus neoformans is a major cause of illness in immunocompromised individuals such as AIDS patients. The ability of the fungus to acquire nutrients during proliferation in host tissue and the ability to elaborate a polysaccharide capsule are critical determinants of disease outcome. We previously showed that the GATA factor, Cir1, is a major regulator both of the iron uptake functions needed for growth in host tissue and the key virulence factors such as capsule, melanin and growth at 37°C. We are interested in further defining the mechanisms of iron acquisition from inorganic and host-derived iron sources with the goal of understanding the nutritional adaptation of C. neoformans to the host environment. In this study, we investigated the roles of the HAP3 and HAPX genes in iron utilization and virulence. As in other fungi, the C. neoformans Hap proteins negatively influence the expression of genes encoding respiratory and TCA cycle functions under low-iron conditions. However, we also found that HapX plays both positive and negative roles in the regulation of gene expression, including a positive regulatory role in siderophore transporter expression. In addition, HapX also positively regulated the expression of the CIR1 transcript. This situation is in contrast to the negative regulation by HapX of genes encoding GATA iron regulatory factors in Aspergillus nidulans and Schizosaccharomyces pombe. Although both hapX and hap3 mutants were defective in heme utilization in culture, only HapX made a contribution to virulence, and loss of HapX in a strain lacking the high-affinity iron uptake system did not cause further attenuation of disease. Therefore, HapX appears to have a minimal role during infection of mammalian hosts and instead may be an important regulator of environmental iron uptake functions. Overall, these results indicated that C. neoformans employs multiple strategies for iron acquisition during infection.

Abnormalities in auditory evoked potentials of 75 patients with Arnold-Chiari malformations types I and II

Directory of Open Access Journals (Sweden)

Henriques Filho Paulo Sergio A.

2006-01-01

Full Text Available OBJECTIVE: To evaluate the frequency and degree of severity of abnormalities in the auditory pathways in patients with Chiari malformations type I and II. METHOD: This is a series-of-case descriptive study in which the possible presence of auditory pathways abnormalities in 75 patients (48 children and 27 adults with Chiari malformation types I and II were analyzed by means of auditory evoked potentials evaluation. The analysis was based on the determination of intervals among potentials peak values, absolute latency and amplitude ratio among potentials V and I. RESULTS: Among the 75 patients studied, 27 (36% disclosed Arnold-Chiari malformations type I and 48 (64% showed Arnold-Chiari malformations type II. Fifty-three (71% of these patients showed some degree of auditory evoked potential abnormalities. Tests were normal in the remaining 22 (29% patients. CONCLUSION: Auditory evoked potentials testing can be considered a valuable instrument for diagnosis and evaluation of brain stem functional abnormalities in patients with Arnold-Chiari malformations type I and II. The determination of the presence and degree of severity of these abnormalities can be contributory to the prevention of further handicaps in these patients either through physical therapy or by means of precocious corrective surgical intervention.

[Study on the anti-NTHi infection of Hap recombinant protein in vivo].

Science.gov (United States)

Li, Wan-yi; Wang, Bao-ning; Zuo, Feng-qiong; Zeng, Wei; Feng, Feng; Kuang, Yu; Jiang, Zhong-hua; Li, Ming-yuan

2010-07-01

To observe the immune effect of Hap recombinant protein on murine model of bronchopneumonia infected with NTHi, and explore the mechanism about the anti-NTHi infection. The C57BL/6 mice intranasally immunized with purified Hap recombinant protein and CT-B were challenged by NTHi encased in agar beads. The immunifaction of anti-infection was observed through encocyte counting of BALF, bacteria detection of lung and the pathologyical change of lung tissue. In the challenge with NTHi experiment, the inflammatory exudation of the infected murine and pathological change of lung tissue was relieved by combined immunization of Hap recombinant protein and CT-B, and quantity of NTHi in lung of the infected murine was reduced obviously. The Hap recombinant protein also had good ability of anti-NTHi infection in the murine model of NTHi bronchopneumonia. This study could offer the oretical and experimental basis for development of new vaccine against NTHi.

40 CFR 63.1565 - What are my requirements for organic HAP emissions from catalytic cracking units?

Science.gov (United States)

2010-07-01

... HAP emissions from catalytic cracking units? 63.1565 Section 63.1565 Protection of Environment... are my requirements for organic HAP emissions from catalytic cracking units? (a) What emission... according to the procedures in the plan. (4) The emission limitations and operating limits for organic HAP...

40 CFR Table 5 to Subpart Oooo of... - Default Organic HAP Mass Fraction for Petroleum Solvent Groups a

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 12 2010-07-01 2010-07-01 true Default Organic HAP Mass Fraction for... 63—Default Organic HAP Mass Fraction for Petroleum Solvent Groups a You may use the mass fraction... formulation data: Solvent type Averageorganic HAP mass fraction Typical organic HAP, percent by mass Aliphatic...

40 CFR Table 4 to Subpart Oooo of... - Default Organic HAP Mass Fraction for Solvents and Solvent Blends

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 12 2010-07-01 2010-07-01 true Default Organic HAP Mass Fraction for... 63—Default Organic HAP Mass Fraction for Solvents and Solvent Blends You may use the mass fraction... formulation data. Solvent/solvent blend CAS. No. Averageorganic HAP mass fraction Typical organic HAP, percent...

Anesthetic management in a child with Arnold-Chiari malformation and bilateral vocal cord paralysis.

NARCIS (Netherlands)

Setz, A.C.W.; Boer, H.D. de; Driessen, J.J.; Scheffer, G.J.

2005-01-01

We report a case of a child who was scheduled for an emergency ventriculoperitoneal shunt procedure. The patient had a type II Arnold-Chiari malformation (ACM) and associated hydrocephalus and presented with near complete respiratory obstruction from bilateral abductor vocal cord palsy. Early

40 CFR Table 3 to Subpart IIIi of... - Default Organic HAP Mass Fraction for Solvents and Solvent Blends

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 12 2010-07-01 2010-07-01 true Default Organic HAP Mass Fraction for... Organic HAP Mass Fraction for Solvents and Solvent Blends You may use the mass fraction values in the... Solvent/solvent blend CAS. No. Averageorganic HAP mass fraction Typical organic HAP, percent by mass 1...

40 CFR Table 4 to Subpart Mmmm of... - Default Organic HAP Mass Fraction for Petroleum Solvent Groups a

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 12 2010-07-01 2010-07-01 true Default Organic HAP Mass Fraction for... Part 63—Default Organic HAP Mass Fraction for Petroleum Solvent Groups a You may use the mass fraction... formulation data. Solvent type Average organic HAP mass fraction Typical organic HAP, percent by mass...

40 CFR Table 4 to Subpart Pppp of... - Default Organic HAP Mass Fraction for Petroleum Solvent Groups a

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 12 2010-07-01 2010-07-01 true Default Organic HAP Mass Fraction for... Organic HAP Mass Fraction for Petroleum Solvent Groups a You may use the mass fraction values in the.... Solvent type Averageorganic HAP mass fraction Typical organic HAP, percent by mass Aliphatic b 0.03 1...

40 CFR Table 4 to Subpart IIIi of... - Default Organic HAP Mass Fraction for Petroleum Solvent Groups a

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 12 2010-07-01 2010-07-01 true Default Organic HAP Mass Fraction for... Organic HAP Mass Fraction for Petroleum Solvent Groups a You may use the mass fraction values in the... Solvent type Averageorganic HAP mass fraction Typical organic HAP, percent by mass Aliphatic b 0.03 1...

40 CFR Table 5 to Subpart Qqqq of... - Default Organic HAP Mass Fraction for Solvents and Solvent Blends

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 12 2010-07-01 2010-07-01 true Default Organic HAP Mass Fraction for... HAP Mass Fraction for Solvents and Solvent Blends You may use the mass fraction values in the.... Solvent/solvent blend CAS. No. Average organic HAP mass fraction Typical organic HAP, percent by mass 1...

Maandatud pinged igavas provintsiriigis - Arnold Rüütli viis aastat Kadriorus / Ivar Tallo

Index Scriptorium Estoniae

Tallo, Ivar, 1964-

2006-01-01

Avaliku halduse ekspert analüüsib president Arnold Rüütli tegevust. Võrdlus president Lennart Meriga. Presidendi kantseleist. Vt. samas: Eesti Vabariigi president on meie põhiseaduse järgi Eesti riigipea, kellel on 20 konkreetset ametiülesannet. Lisa: President Rüütli tähtsamad abilised esimesel ametiajal

40 CFR Table 6 to Subpart Qqqq of... - Default Organic HAP Mass Fraction for Petroleum Solvent Groups a

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 12 2010-07-01 2010-07-01 true Default Organic HAP Mass Fraction for... HAP Mass Fraction for Petroleum Solvent Groups a You may use the mass fraction values in the following... type Average organic HAP mass fraction Typical organic HAP, percent by mass Aliphatic b 0.03 1% xylene...

40 CFR Table 3 to Subpart Nnnn of... - Default Organic HAP Mass Fraction for Solvents and Solvent Blends

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 12 2010-07-01 2010-07-01 true Default Organic HAP Mass Fraction for... Large Appliances Pt. 63, Subpt. NNNN, Table 3 Table 3 to Subpart NNNN of Part 63—Default Organic HAP.../solvent blend CAS. No. Average organic HAP mass fraction Typical organic HAP, percent by mass 1. Toluene...

40 CFR 63.1564 - What are my requirements for metal HAP emissions from catalytic cracking units?

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 12 2010-07-01 2010-07-01 true What are my requirements for metal HAP... requirements for metal HAP emissions from catalytic cracking units? (a) What emission limitations and work... and operating limits for metal HAP emissions from catalytic cracking units required in paragraphs (a...

Algoritmos genéticos locales

OpenAIRE

García-Martínez, Carlos; Lozano, Manuel

2007-01-01

Los Algoritmos Genéticos Locales son procedimientos que iterativamente re nan soluciones dadas. Su diferencia con procedimientos de mejora iterativa clásicos reside en el uso de operadores genéticos para realizar el re namiento. En este estudio presentamos un nuevo Algoritmo Genético Local Binario basado en un Algoritmo Genético Estacionario. Hemos comparado el Algoritmo Genético Local Binario con otros procedimientos de mejora iterativa de la literatura. Los res...

40 CFR Table 3 to Subpart Rrrr of... - Default Organic HAP Mass Fraction for Solvents and Solvent Blends

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 12 2010-07-01 2010-07-01 true Default Organic HAP Mass Fraction for... Metal Furniture Pt. 63, Subpt. RRRR, Table 3 Table 3 to Subpart RRRR of Part 63—Default Organic HAP Mass... blend CAS. No. Average organic HAP mass fraction Typical organic HAP, percent by mass 1. Toluene 108-88...

40 CFR Table 6 to Subpart Kkkk of... - Default Organic HAP Mass Fraction for Solvents and Solvent Blends

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 12 2010-07-01 2010-07-01 true Default Organic HAP Mass Fraction for... Metal Cans Pt. 63, Subpt. KKKK, Table 6 Table 6 to Subpart KKKK of Part 63—Default Organic HAP Mass... blend CAS. No. Averageorganic HAP mass fraction Typical organic HAP, percent by mass 1. Toluene 108-88-3...

40 CFR Table 4 to Subpart Rrrr of... - Default Organic HAP Mass Fraction for Petroleum Solvent Groups 1

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 12 2010-07-01 2010-07-01 true Default Organic HAP Mass Fraction for... Metal Furniture Pt. 63, Subpt. RRRR, Table 4 Table 4 to Subpart RRRR of Part 63—Default Organic HAP Mass... Average organic HAP mass fraction Typical organic percent HAP, by mass Aliphatic 2 0.03 1% Xylene, 1...

40 CFR Table 4 to Subpart Nnnn of... - Default Organic HAP Mass Fraction for Petroleum Solvent Groups a

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 12 2010-07-01 2010-07-01 true Default Organic HAP Mass Fraction for... Large Appliances Pt. 63, Subpt. NNNN, Table 4 Table 4 to Subpart NNNN of Part 63—Default Organic HAP... type Average organic HAP mass fraction Typical organic HAP, percent by mass Aliphatic b 0.03 1% Xylene...

40 CFR Table 7 to Subpart Kkkk of... - Default Organic HAP Mass Fraction for Petroleum Solvent Groups a

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 12 2010-07-01 2010-07-01 true Default Organic HAP Mass Fraction for... Metal Cans Pt. 63, Subpt. KKKK, Table 7 Table 7 to Subpart KKKK of Part 63—Default Organic HAP Mass... Averageorganic HAP mass fraction Typicalorganic HAP, percent by mass Aliphatic b 0.03 1% Xylene, 1% toluene, and...

Parallel nano-assembling of a multifunctional GO/HapNP coating on ultrahigh-purity magnesium for biodegradable implants

International Nuclear Information System (INIS)

Santos, C.; Piedade, C.; Uggowitzer, P.J.; Montemor, M.F.; Carmezim, M.J.

2015-01-01

Graphical abstract: - Highlights: • A GO/HapNP thin coating was applied on XHP-Mg using a parallel nano-assembling route. • The coating surface wettability can be controlled by adding HapNP and/or GO. • Nanostructured GO/HapNP/phosphate coating promotes the apatite mineralization. • Critical properties, including degradation on SBF, of the coating were studied. - Abstract: This work reports the one-step fabrication of a novel coating on ultra high purity magnesium using a parallel nano assembling process. The multifunctional biodegradable surface was obtained by adding hydroxyapatite nanoparticles (HapNP) plus graphene oxide (GO). The coating was characterized by scanning electron microscope (SEM), transmission electron microscope (TEM), X-ray diffractometer (XRD), micro-Raman spectroscopy. The thin phosphate coating (thickness of 1 μm) reveals a uniform coverage with cypress like structures. The incorporation of HapNP and GO promotes the hydrophilic behavior of the coating surface. The results revealed that the proposed coating can be used to tailor the surface properties such as wettability by adjusting the contents of HapNP and GO. The in vitro degradation rate of the coated magnesium suggests that the presence of HapNP and GO/HapNP in the phosphate coating decreased the current density compared to the single phosphate coating and uncoated magnesium. This study also reveals the HapNP/GO/phosphate coating induces apatite formation, showing suitable degradability that makes it a promising coating candidate for enhanced bone regeneration

Parallel nano-assembling of a multifunctional GO/HapNP coating on ultrahigh-purity magnesium for biodegradable implants

Energy Technology Data Exchange (ETDEWEB)

Santos, C., E-mail: catarina.santos@estsetubal.ips.pt [EST Setúbal, DEM, Instituto Politécnico de Setúbal, Campus IPS, 2914-508 Setúbal (Portugal); CQE, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisboa (Portugal); Piedade, C. [EST Setúbal, DEM, Instituto Politécnico de Setúbal, Campus IPS, 2914-508 Setúbal (Portugal); Uggowitzer, P.J. [Laboratory of Metal Physics and Technology, ETH Zurich, 8093 Zurich (Switzerland); Montemor, M.F. [CQE, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisboa (Portugal); Carmezim, M.J. [EST Setúbal, DEM, Instituto Politécnico de Setúbal, Campus IPS, 2914-508 Setúbal (Portugal); CQE, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisboa (Portugal)

2015-08-01

Graphical abstract: - Highlights: • A GO/HapNP thin coating was applied on XHP-Mg using a parallel nano-assembling route. • The coating surface wettability can be controlled by adding HapNP and/or GO. • Nanostructured GO/HapNP/phosphate coating promotes the apatite mineralization. • Critical properties, including degradation on SBF, of the coating were studied. - Abstract: This work reports the one-step fabrication of a novel coating on ultra high purity magnesium using a parallel nano assembling process. The multifunctional biodegradable surface was obtained by adding hydroxyapatite nanoparticles (HapNP) plus graphene oxide (GO). The coating was characterized by scanning electron microscope (SEM), transmission electron microscope (TEM), X-ray diffractometer (XRD), micro-Raman spectroscopy. The thin phosphate coating (thickness of 1 μm) reveals a uniform coverage with cypress like structures. The incorporation of HapNP and GO promotes the hydrophilic behavior of the coating surface. The results revealed that the proposed coating can be used to tailor the surface properties such as wettability by adjusting the contents of HapNP and GO. The in vitro degradation rate of the coated magnesium suggests that the presence of HapNP and GO/HapNP in the phosphate coating decreased the current density compared to the single phosphate coating and uncoated magnesium. This study also reveals the HapNP/GO/phosphate coating induces apatite formation, showing suitable degradability that makes it a promising coating candidate for enhanced bone regeneration.

Theology of Arnold of Villanova: between Bible and politics

Directory of Open Access Journals (Sweden)

Bogusław Kochaniewicz

2011-09-01

Full Text Available Biblical interpretation of Arnold of Villanova manifests us not only a specific and particular current of exegesis within 14th century. He emphasised the idea of eschaton fullfilled, manifested through the history more and more clear and perfect. His exegesis, based on Joachim de Fiore’s work presented the Bible as an instrument of the historical knowledge. The Bible, interpreted in allegorical perspective, manifested the meaning of the events pasted and presents and future. In order that Bible could be always actual, it required miracles and apparitions, which would support and manifest extraordinary divine interventions within the history of the world. In Arnold’s opinion, the Bible, without miracles and mistical experiences, could lost its own meaning. Arnold of Villanova, being inspired by the Franciscan spiritual movement, strived to evidence the ideas of the nearness of the end of the world. Even if he was not an eminent theologian, he impressed and inspired his epoch. Therefore his name is mentioned by the manuals of the history of theology.

40 CFR 63.1297 - Standards for slabstock flexible polyurethane foam production-HAP ABA emissions from the...

Science.gov (United States)

2010-07-01

... polyurethane foam production-HAP ABA emissions from the production line. 63.1297 Section 63.1297 Protection of... foam production—HAP ABA emissions from the production line. (a) Each owner or operator of a new or... § 63.1293(a)(1) shall control HAP ABA emissions from the slabstock polyurethane foam production line in...

Unique C-terminal region of Hap3 is required for methanol-regulated gene expression in the methylotrophic yeast Candida boidinii.

Science.gov (United States)

Oda, Saori; Yurimoto, Hiroya; Nitta, Nobuhisa; Sakai, Yasuyoshi

2016-05-01

The Hap complex of the methylotrophic yeast Candida boidinii was found to be required for methanol-regulated gene expression. In this study, we performed functional characterization of CbHap3p, one of the Hap complex components in C. boidinii. Sequence alignment of Hap3 proteins revealed the presence of a unique extended C-terminal region, which is not present in Hap3p from Saccharomyces cerevisiae (ScHap3p), but is found in Hap3p proteins of methylotrophic yeasts. Deletion of the C-terminal region of CbHap3p (Δ256-292 or Δ107-237) diminished activation of methanol-regulated genes and abolished the ability to grow on methanol, but did not affect nuclear localization or DNA-binding ability. However, deletion of the N-terminal region of CbHap3p (Δ1-20) led to not only a growth defect on methanol and a decreased level of methanol-regulated gene expression, but also impaired nuclear localization and binding to methanol-regulated gene promoters. We also revealed that CbHap3p could complement the growth defect of the Schap3Δ strain on glycerol, although ScHap3p could not complement the growth defect of a Cbhap3Δ strain on methanol. We conclude that the unique C-terminal region of CbHap3p contributes to maximum activation of methanol-regulated genes, whilst the N-terminal region is required for nuclear localization and binding to DNA.

The Quantum Arnold Transformation for the damped harmonic oscillator: from the Caldirola-Kanai model toward the Bateman model

Science.gov (United States)

López-Ruiz, F. F.; Guerrero, J.; Aldaya, V.; Cossío, F.

2012-08-01

Using a quantum version of the Arnold transformation of classical mechanics, all quantum dynamical systems whose classical equations of motion are non-homogeneous linear second-order ordinary differential equations (LSODE), including systems with friction linear in velocity such as the damped harmonic oscillator, can be related to the quantum free-particle dynamical system. This implies that symmetries and simple computations in the free particle can be exported to the LSODE-system. The quantum Arnold transformation is given explicitly for the damped harmonic oscillator, and an algebraic connection between the Caldirola-Kanai model for the damped harmonic oscillator and the Bateman system will be sketched out.

The Quantum Arnold Transformation for the damped harmonic oscillator: from the Caldirola-Kanai model toward the Bateman model

International Nuclear Information System (INIS)

López-Ruiz, F F; Guerrero, J; Aldaya, V; Cossío, F

2012-01-01

Using a quantum version of the Arnold transformation of classical mechanics, all quantum dynamical systems whose classical equations of motion are non-homogeneous linear second-order ordinary differential equations (LSODE), including systems with friction linear in velocity such as the damped harmonic oscillator, can be related to the quantum free-particle dynamical system. This implies that symmetries and simple computations in the free particle can be exported to the LSODE-system. The quantum Arnold transformation is given explicitly for the damped harmonic oscillator, and an algebraic connection between the Caldirola-Kanai model for the damped harmonic oscillator and the Bateman system will be sketched out.

Divergência genética entre genótipos de frangos tipo caipira

Directory of Open Access Journals (Sweden)

R. C. Veloso

2015-10-01

Full Text Available RESUMOObjetivou-se com este trabalho verificar a divergência genética entre sete genótipos de frangos tipo caipira da linhagem Redbro utilizando as características de desempenho por meio de técnicas de análise multivariada. Foram utilizados 840 pintos de um dia, machos, distribuídos em delineamento inteiramente ao acaso, dos seguintes genótipos: Caboclo, Carijó, Colorpak, Gigante Negro, Pesadão Vermelho, Pescoço Pelado e Tricolor. Após a consistência dos dados, foram avaliadas as seguintes variáveis: ganho em peso médio diário, consumo de ração médio diário e conversão alimentar, para os períodos: 1 a 28, 1 a 56, 1 a 70 e 1 a 84 dias de idade; peso corporal ao nascimento, aos 28, 56, 70 e aos 84 dias de idade. O desempenho dos genótipos foi avaliado por meio da análise de variância multivariada e da função discriminante linear de Fisher, usando os testes do maior autovalor de Roy e da união-interseção de Roy para as comparações múltiplas. O estudo da divergência genética foi feito por meio da análise por variáveis canônicas e pelo método de otimização de Tocher. Os genótipos Caboclo e Gigante Negro apresentaram médias canônicas diferentes dos demais genótipos. As duas primeiras variáveis canônicas explicaram 97,41% da variação entre os genótipos. A divergência genética entre os genótipos avaliados permitiu a formação de quatro grupos com os seguintes genótipos: grupo 1 - Colorpak; grupo 2 - Pesadão Vermelho e Pescoço Pelado; grupo 3 - Carijó e Tricolor; e grupo 4 - Caboclo e Gigante Negro.

Kõrgeid ja inimlikke sihte / Arnold Rüütel

Index Scriptorium Estoniae

Rüütel, Arnold

2006-01-01

President Arnold Rüütli uusaastaläkitus. Ilmunud ka Postimees : na russkom jazõke (2006/Jan/3) lk. 7 ; Pärnu Postimees (2006/Jan/3) lk. 11 ; Virumaa Teataja (2006/Jan/3) lk. 7 ; Järva Teataja (2006/Jan/3) lk. 2 ; Võrumaa Teataja (2006/Jan/3) lk. 2 ; Põhjarannik (2006/Jan/3) lk. 2 ; Severnoje Poberezhje (2006/Jan/3) lk. 2 ; Meie Maa (2006/Jan/3) lk. 2 ; Hiiu Leht (2006/Jan/3) lk. 2; Eesti Päevaleht, lüh. (2006/Jan/3) lk. 3; Maaleht (2006/Jan/5) lk. 6 ; Lääne-Harju Ekspress (2006/Jan/7) lk. 3; Vaba Eesti Sõna = Free Estonian Word, 2006/Jan/5, lk. 2

40 CFR Table 6 to Subpart Vvvv of... - Default Organic HAP Contents of Petroleum Solvent Groups

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 12 2010-07-01 2010-07-01 true Default Organic HAP Contents of... Manufacturing Pt. 63, Subpt. VVVV, Table 6 Table 6 to Subpart VVVV of Part 63—Default Organic HAP Contents of Petroleum Solvent Groups As specified in § 63.5758(a)(6), when detailed organic HAP content data for solvent...

40 CFR Table 2 to Subpart II of... - Volatile Organic HAP (VOHAP) Limits for Marine Coatings

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 10 2010-07-01 2010-07-01 false Volatile Organic HAP (VOHAP) Limits... (Surface Coating) Pt. 63, Subpt. II, Table 2 Table 2 to Subpart II of Part 63—Volatile Organic HAP (VOHAP...) through (4). b VOC (including exempt compounds listed as HAP) shall be used as a surrogate for VOHAP for...

Electrospun PVA/HAp nanocomposite nanofibers: biomimetics of mineralized hard tissues at a lower level of complexity.

Science.gov (United States)

Kim, Gyeong-Man; Asran, Ashraf Sh; Michler, Georg H; Simon, Paul; Kim, Jeong-Sook

2008-12-01

Based on the biomimetic approaches the present work describes a straightforward technique to mimic not only the architecture (the morphology) but also the chemistry (the composition) of the lowest level of the hierarchical organization of bone. This technique uses an electrospinning (ES) process with polyvinyl alcohol (PVA) and hydroxyapatite (HAp) nanoparticles. To determine morphology, crystalline structures and thermal properties of the resulting electrospun fibers with the pure PVA and PVA/HAp nanocomposite (NC) before electrospinning various techniques were employed, including transmission electron microscopy (TEM), high-resolution TEM (HR-TEM), scanning electron microscopy (SEM), x-ray diffraction (XRD), differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA). In addition, FT-IR spectroscopy was carried out to analyze the complex structural changes upon undergoing electrospinning as well as interactions between HAp and PVA. The morphological and crystallographic investigations revealed that the rod-like HAp nanoparticles exhibit a nanoporous morphology and are embedded within the electrospun fibers. A large number of HAp nanorods are preferentially oriented parallel to the longitudinal direction of the electrospun PVA fibers, which closely resemble the naturally mineralized hard tissues of bones. Due to abundant OH groups present in PVA and HAp nanorods, they strongly interact via hydrogen bonding within the electrospun PVA/HAp NC fibers, which results in improved thermal properties. The unique physiochemical features of the electrospun PVA/HAp NC nanofibers prepared by the ES process will open up a wide variety of future applications related to hard tissue replacement and regeneration (bone and dentin), not limited to coating implants.

Electrospun PVA/HAp nanocomposite nanofibers: biomimetics of mineralized hard tissues at a lower level of complexity

Energy Technology Data Exchange (ETDEWEB)

Kim, Gyeong-Man; Asran, Ashraf Sh; Michler, Georg H [Institute of Physics, Martin-Luther-University Halle-Wittenberg, D-06099 Halle/S (Germany); Simon, Paul [Max-Planck Institute for Chemical Physics of Solids, Noethnitzer Strasse 40, D-01187 Dresden (Germany); Kim, Jeong-Sook [Department of Dental Technology, Daegu Health College, 702-722 Daegu (Korea, Republic of)], E-mail: gyeong.kim@physik.uni-halle.de

2008-12-01

Based on the biomimetic approaches the present work describes a straightforward technique to mimic not only the architecture (the morphology) but also the chemistry (the composition) of the lowest level of the hierarchical organization of bone. This technique uses an electrospinning (ES) process with polyvinyl alcohol (PVA) and hydroxyapatite (HAp) nanoparticles. To determine morphology, crystalline structures and thermal properties of the resulting electrospun fibers with the pure PVA and PVA/HAp nanocomposite (NC) before electrospinning various techniques were employed, including transmission electron microscopy (TEM), high-resolution TEM (HR-TEM), scanning electron microscopy (SEM), x-ray diffraction (XRD), differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA). In addition, FT-IR spectroscopy was carried out to analyze the complex structural changes upon undergoing electrospinning as well as interactions between HAp and PVA. The morphological and crystallographic investigations revealed that the rod-like HAp nanoparticles exhibit a nanoporous morphology and are embedded within the electrospun fibers. A large number of HAp nanorods are preferentially oriented parallel to the longitudinal direction of the electrospun PVA fibers, which closely resemble the naturally mineralized hard tissues of bones. Due to abundant OH groups present in PVA and HAp nanorods, they strongly interact via hydrogen bonding within the electrospun PVA/HAp NC fibers, which results in improved thermal properties. The unique physiochemical features of the electrospun PVA/HAp NC nanofibers prepared by the ES process will open up a wide variety of future applications related to hard tissue replacement and regeneration (bone and dentin), not limited to coating implants.

Presidendi kõne Eesti Vabariigi 87. aastapäeval / Arnold Rüütel

Index Scriptorium Estoniae

Rüütel, Arnold, 1928-

2005-01-01

Ilmunud ka: Teataja : Eestimaa Rahvaliidu Ajaleht (2005) märts, nr. 3, lk. 1 ; Narva Postiljon (2005) 26. veebr.. lk. 2 ; SL Õhtuleht (2005) 25. veebr. (lüh.) ; Narva Postiljon (2005) 25. veebr. (lüh.). President Arnold Rüütli kõne 24. veebruaril Estonia teatrisaalis. Presidendi sõnul peab Eesti edasine areng olema tasakaalustatud

Hap2, a novel gene in Babesia bigemina is expressed in tick stages, and specific antibodies block zygote formation

Directory of Open Access Journals (Sweden)

Minerva Camacho-Nuez

2017-11-01

Full Text Available Abstract Background Bovine babesiosis is a tick-borne disease caused by the protozoan parasites of the genus Babesia. In their host vector, Babesia spp. undergo sexual reproduction. Therefore, the development of sexual stages and the subsequent formation of the zygote are essential for the parasite to invade the intestinal cells of the vector tick and continue its life-cycle. HAP2/GCS1 is a protein identified in plants, protozoan parasites and other organisms that has an important role during membrane fusion in fertilization processes. The identification and characterization of HAP-2 protein in Babesia would be very significant to understand the biology of the parasite and to develop a transmission-blocking vaccine in the future. Results To isolate and sequence the hap2 gene DNA from an infected bovine with Babesia bigemina was purified. The hap2 gene was amplified, cloned and sequenced. The sequences of hap2 from four geographically different strains showed high conservation at the amino acid level, including the typical structure with a signal peptide and the HAP2/GSC domain. Antisera anti-HAP2 against the conserved extracellular region of the HAP2 amino acid sequence were obtained from rabbits. The expression of hap2 in the host and vector tissues was analyzed by using semi-quantitative RT-PCR, and the protein was examined by western blot and immunofluorescence. Based on the RT-PCR and WB results, HAP2 is expressed in both, sexual stages induced in vitro, and in infected ticks as well. We did not detect any expression in asexual erythrocytic stages of B. bigemina, relevantly anti-HAP2 specific antibodies were able to block zygotes formation in vitro. Conclusion Babesia bigemina HAP2 is expressed only in tick-infecting stages, and specific antibodies block zygote formation. Further studies regarding the function of HAP2 during tick infection may provide new insights into the molecular mechanisms of sexual reproduction of the parasite.

Evaluation of model-predicted hazardous air pollutants (HAPs) near a mid-sized U.S. airport

Science.gov (United States)

Vennam, Lakshmi Pradeepa; Vizuete, William; Arunachalam, Saravanan

2015-10-01

Accurate modeling of aircraft-emitted pollutants in the vicinity of airports is essential to study the impact on local air quality and to answer policy and health-impact related issues. To quantify air quality impacts of airport-related hazardous air pollutants (HAPs), we carried out a fine-scale (4 × 4 km horizontal resolution) Community Multiscale Air Quality model (CMAQ) model simulation at the T.F. Green airport in Providence (PVD), Rhode Island. We considered temporally and spatially resolved aircraft emissions from the new Aviation Environmental Design Tool (AEDT). These model predictions were then evaluated with observations from a field campaign focused on assessing HAPs near the PVD airport. The annual normalized mean error (NME) was in the range of 36-70% normalized mean error for all HAPs except for acrolein (>70%). The addition of highly resolved aircraft emissions showed only marginally incremental improvements in performance (1-2% decrease in NME) of some HAPs (formaldehyde, xylene). When compared to a coarser 36 × 36 km grid resolution, the 4 × 4 km grid resolution did improve performance by up to 5-20% NME for formaldehyde and acetaldehyde. The change in power setting (from traditional International Civil Aviation Organization (ICAO) 7% to observation studies based 4%) doubled the aircraft idling emissions of HAPs, but led to only a 2% decrease in NME. Overall modeled aircraft-attributable contributions are in the range of 0.5-28% near a mid-sized airport grid-cell with maximum impacts seen only within 4-16 km from the airport grid-cell. Comparison of CMAQ predictions with HAP estimates from EPA's National Air Toxics Assessment (NATA) did show similar annual mean concentrations and equally poor performance. Current estimates of HAPs for PVD are a challenge for modeling systems and refinements in our ability to simulate aircraft emissions have made only incremental improvements. Even with unrealistic increases in HAPs aviation emissions the model

Influence of Growth Parameters on the Formation of Hydroxyapatite (HAp) Nanostructures and Their Cell Viability Studies

OpenAIRE

Manoj, Murugesan; Subbiah, Ramesh; Mangalaraj, Devanesan; Ponpandian, Nagamony; Viswanathan, Chinnuswamy; Park, Kwideok

2015-01-01

Morphology controlled hydroxyapatite (HAp) nanostruc‐ tures play a vital role in biomedical engineering, tissue regenerative medicine, biosensors, chemotherapeutic applications, environmental remediation, etc. The present work investigates the influence of temperature, pH and time on the growth of HAp nanostructures using a simple, cost effective and surfactant free chemical approach. The obtained HAp nanostructures were systematically investi‐ gated by analytical techniques such as XRD, FESE...

GenBank

OpenAIRE

Benson, Dennis A.; Cavanaugh, Mark; Clark, Karen; Karsch-Mizrachi, Ilene; Lipman, David J.; Ostell, James; Sayers, Eric W.

2012-01-01

GenBank? (http://www.ncbi.nlm.nih.gov) is a comprehensive database that contains publicly available nucleotide sequences for almost 260 000 formally described species. These sequences are obtained primarily through submissions from individual laboratories and batch submissions from large-scale sequencing projects, including whole-genome shotgun (WGS) and environmental sampling projects. Most submissions are made using the web-based BankIt or standalone Sequin programs, and GenBank staff assig...

40 CFR Table 9 to Subpart Ggg of... - Default Biorates for Soluble HAP

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 11 2010-07-01 2010-07-01 true Default Biorates for Soluble HAP 9 Table 9 to Subpart GGG of Part 63 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED... Subpart GGG of Part 63—Default Biorates for Soluble HAP Compound name Biorate (K1),L/g MLVSS-hr...

Personal benefits of public open space: a case study in Boston's Arnold Arboretum

Science.gov (United States)

Thomas A. More; John Blackwell

1998-01-01

Managers of urban parks need to document the benefits that their parks produce. Use level is a typical measure of such benefits, but simple use statistics can mask the rich diversity of people and activities that the parks serve. This study examined the uses and users of Boston's Arnold Arboretum during late summer in 1992. On 25 sample days, we recorded...

40 CFR Table 4 to Subpart Vvvvvv... - Emission Limits and Compliance Requirements for Metal HAP Process Vents

Science.gov (United States)

2010-07-01

... Requirements for Metal HAP Process Vents 4 Table 4 to Subpart VVVVVV of Part 63 Protection of Environment... of Part 63—Emission Limits and Compliance Requirements for Metal HAP Process Vents As required in § 63.11496(f), you must comply with the requirements for metal HAP process vents as shown in the...

Arnold tongues and the Devil's Staircase in a discrete-time Hindmarsh–Rose neuron model

Energy Technology Data Exchange (ETDEWEB)

Felicio, Carolini C., E-mail: carolini.cf@gmail.com; Rech, Paulo C., E-mail: paulo.rech@udesc.br

2015-11-06

We investigate a three-dimensional discrete-time dynamical system, described by a three-dimensional map derived from a continuous-time Hindmarsh–Rose neuron model by the forward Euler method. For a fixed integration step size, we report a two-dimensional parameter-space for this system, where periodic structures, the so-called Arnold tongues, can be seen with periods organized in a Farey tree sequence. We also report possible modifications in this parameter-space, as a function of the integration step size. - Highlights: • We investigate the parameter-space of a particular 3D map. • Periodic structures, namely Arnold tongues, can be seen there. • They are organized in a Farey tree sequence. • The map was derived from a continuous-time Hindmarsh–Rose neuron model. • The forward Euler method was used for such purpose.

Parallel nano-assembling of a multifunctional GO/HapNP coating on ultrahigh-purity magnesium for biodegradable implants

Science.gov (United States)

Santos, C.; Piedade, C.; Uggowitzer, P. J.; Montemor, M. F.; Carmezim, M. J.

2015-08-01

This work reports the one-step fabrication of a novel coating on ultra high purity magnesium using a parallel nano assembling process. The multifunctional biodegradable surface was obtained by adding hydroxyapatite nanoparticles (HapNP) plus graphene oxide (GO). The coating was characterized by scanning electron microscope (SEM), transmission electron microscope (TEM), X-ray diffractometer (XRD), micro-Raman spectroscopy. The thin phosphate coating (thickness of 1 μm) reveals a uniform coverage with cypress like structures. The incorporation of HapNP and GO promotes the hydrophilic behavior of the coating surface. The results revealed that the proposed coating can be used to tailor the surface properties such as wettability by adjusting the contents of HapNP and GO. The in vitro degradation rate of the coated magnesium suggests that the presence of HapNP and GO/HapNP in the phosphate coating decreased the current density compared to the single phosphate coating and uncoated magnesium. This study also reveals the HapNP/GO/phosphate coating induces apatite formation, showing suitable degradability that makes it a promising coating candidate for enhanced bone regeneration.

Arnold Rüütel alustas oma Valgamaa visiiti Tõrvas ja Otepääl / Urve Sinisalu

Index Scriptorium Estoniae

Sinisalu, Urve, 1945-

2002-01-01

President Arnold Rüütli visiidist Valgamaale. Kohtumisest Tõrva Gümnaasiumi direktori Ivar Hanvere ja Tõrva linnapea Väino Tõemetsaga, külaskäigust Ants Tauli torupillitallu. Kommenteerib Ingrid Rüütel. Maakonnavisiit Valgamaale 23.-24.09.2002

40 CFR Table 1 to Subpart Dd of... - List of Hazardous Air Pollutants (HAP) for Subpart DD

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 10 2010-07-01 2010-07-01 false List of Hazardous Air Pollutants (HAP... Hazardous Air Pollutants (HAP) for Subpart DD CAS No. a Chemical name fm 305 75-07-0 Acetaldehyde 1.000 75... mixtures of compounds. b. Denotes a HAP that hydrolyzes quickly in water, but the hydrolysis products are...

40 CFR Table 5 to Subpart Vvvv of... - Default Organic HAP Contents of Solvents and Solvent Blends

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 12 2010-07-01 2010-07-01 true Default Organic HAP Contents of... Manufacturing Pt. 63, Subpt. VVVV, Table 5 Table 5 to Subpart VVVV of Part 63—Default Organic HAP Contents of Solvents and Solvent Blends As specified in § 63.5758(a)(6), when detailed organic HAP content data for...

GenBank

OpenAIRE

Benson, Dennis A.; Karsch-Mizrachi, Ilene; Lipman, David J.; Ostell, James; Sayers, Eric W.

2008-01-01

GenBank? is a comprehensive database that contains publicly available nucleotide sequences for more than 300 000 organisms named at the genus level or lower, obtained primarily through submissions from individual laboratories and batch submissions from large-scale sequencing projects. Most submissions are made using the web-based BankIt or standalone Sequin programs, and accession numbers are assigned by GenBank? staff upon receipt. Daily data exchange with the European Molecular Biology Labo...

Reparación de fracturas de suelo orbitario con hidroxiapatita HAP-200 Repair of orbital floor fractures with HAP-200 hydroxyapatite

Directory of Open Access Journals (Sweden)

Juan Carlos Quintana Díaz

2005-12-01

Full Text Available Se realizó un estudio clínico y radiográfico pre y posoperatorio en 4 pacientes con fracturas del suelo orbitario reparadas con hidroxiapatita HAP-200. En ninguno de los pacientes se encontró reacción adversa ante este material implantalógico y sí muy buena tolerancia y adaptabilidad, lo que nos reafirmó su alta biocompatibilidad, por lo que lo recomendamos en el tratamiento de esta afección.A pre- and postoperative clinical and X-ray study was conducted in 4 patients with orbital floor fractures repaired with HAP-200hydroxyapatite. . No adverse reaction to this material was observed in any of the patients, who showed a good tolerance and adaptability that confirmed its high biocompatibility and make it recommendable for treating this affection.

Rüütel jäi kommunistinagi iseendaks / Arnold Rüütel ; intervjueerinud Hille Tänavsuu

Index Scriptorium Estoniae

Rüütel, Arnold, 1928-

2001-01-01

Arnold Rüütlile esitatud küsimused puudutavad tema minevikku, suhtumist noorte pahameeleavaldustesse pärast A. Rüütli valimist presidendiks, presidendi võimalusi mõjutada asjade käiku, president Lennart Merit, salaalkoholi leviku põhjusi jm. Parlamendisaadik

Combined Spinal-Epidural Analgesia for Laboring Parturient with Arnold-Chiari Type I Malformation: A Case Report and a Review of the Literature

Directory of Open Access Journals (Sweden)

Clark K. Choi

2013-01-01

Full Text Available Anesthetic management of laboring parturients with Arnold-Chiari type I malformation poses a difficult challenge for the anesthesiologist. The increase in intracranial pressure during uterine contractions, coughing, valsalva maneuvers, and expulsion of the fetus can be detrimental to the mother during the process of labor and delivery. No concrete evidence has implicated high cerebral spinal fluid pressure on maternal and fetal complications. The literature on the use of neuraxial techniques for managing parturients with Arnold-Chiari is extremely scarce. While most anesthesiologists advocate epidural analgesia for management of labor pain and spinal anesthesia for cesarean section, we are the first to report the use of combined spinal-epidural analgesia for managing labor pain in a pregnant woman with Arnold-Chiari type I malformation. Also, we have reviewed the literature and presented information from case reports and case series to support the safe usage of neuraxial techniques in these patients.

GenBank

OpenAIRE

Benson, Dennis A.; Karsch-Mizrachi, Ilene; Lipman, David J.; Ostell, James; Wheeler, David L.

2006-01-01

GenBank (R) is a comprehensive database that contains publicly available nucleotide sequences for more than 240 000 named organisms, obtained primarily through submissions from individual laboratories and batch submissions from large-scale sequencing projects. Most submissions are made using the web-based BankIt or standalone Sequin programs and accession numbers are assigned by GenBank staff upon receipt. Daily data exchange with the EMBL Data Library in Europe and the DNA Data Bank of Japan...

Tackling the problem of fine particulate (HAP) collection

Energy Technology Data Exchange (ETDEWEB)

Parker, K.; Sanyal, A.

2000-07-01

With increasing concern over the emission of hazardous air pollutants (HAPs), measures are being considered to limit their discharge from many industrial sources. The main thrust o the proposed legislation is towards the power generators, because of their potentially large mass emissions, but also at specific targets, such as incinerators. Legislation already exists governing the emission of heavy metals, etc., from various types of incineration process and regulations controlling the emission of pM 2.5 material are proposed for the US. Provided the HAPs are in a solid particulate phase then their collection can be accomplished by correctly designed and operated control systems, such as electrostatic precipitators and bag filters. There are, however, other HAP species which are usually in a gaseous phase at normal back end temperatures, such as elemental mercury, dioxins, furans, etc. These need special consideration and equipment in order to satisfy the proposed regulations. one of the difficulties facing the designers and operators of processes giving rise to these species is the accurate measurement of these trace elements and predicting the uncontrolled emission level in order to size the collection system such as to remain in compliance. The options for the effective collection of these normally gaseous phase pollutants will be examined; these methods will include combined wet and dry collection, absorption and carbon injection systems. Finally, whichever system is finally considered and adopted, in order to satisfy and proposed regulations, will add significant capital and operating cost to the overall installation.

40 CFR 63.5752 - How do I calculate the organic HAP content of aluminum recreational boat surface coatings?

Science.gov (United States)

2010-07-01

... Manufacturing Standards for Aluminum Recreational Boat Surface Coating Operations § 63.5752 How do I calculate... fraction of organic HAP in coating i, kilograms of organic HAP per kilogram of coating. p = number of..., activator, or additive k, kilograms per liter. Wk= mass fraction of organic HAP in thinner, activator, or...

Comparison of HapMap and 1000 Genomes Reference Panels in a Large-Scale Genome-Wide Association Study.

Directory of Open Access Journals (Sweden)

Paul S de Vries

Full Text Available An increasing number of genome-wide association (GWA studies are now using the higher resolution 1000 Genomes Project reference panel (1000G for imputation, with the expectation that 1000G imputation will lead to the discovery of additional associated loci when compared to HapMap imputation. In order to assess the improvement of 1000G over HapMap imputation in identifying associated loci, we compared the results of GWA studies of circulating fibrinogen based on the two reference panels. Using both HapMap and 1000G imputation we performed a meta-analysis of 22 studies comprising the same 91,953 individuals. We identified six additional signals using 1000G imputation, while 29 loci were associated using both HapMap and 1000G imputation. One locus identified using HapMap imputation was not significant using 1000G imputation. The genome-wide significance threshold of 5×10-8 is based on the number of independent statistical tests using HapMap imputation, and 1000G imputation may lead to further independent tests that should be corrected for. When using a stricter Bonferroni correction for the 1000G GWA study (P-value < 2.5×10-8, the number of loci significant only using HapMap imputation increased to 4 while the number of loci significant only using 1000G decreased to 5. In conclusion, 1000G imputation enabled the identification of 20% more loci than HapMap imputation, although the advantage of 1000G imputation became less clear when a stricter Bonferroni correction was used. More generally, our results provide insights that are applicable to the implementation of other dense reference panels that are under development.

Hilson Adolescent Profile (HAP): Hilson Research Abstracts.

Science.gov (United States)

Hilson Research Inc., Kew Gardens, NY.

Abstracts and bibliographic citations are given for the following documents concerned with the use and characteristics of the Hilson Adolescent Profile (HAP): (1) "Use of the Hilson Adolescent Profile To Compare Juvenile Offenders with Junior and Senior High School Students" (R. E. Inwald and K. E. Brobst); (2) "The Effectiveness of…

A new series of HAPs as anti-HBV agents targeting at capsid assembly.

Science.gov (United States)

Yang, Xiu-yan; Xu, Xiao-qian; Guan, Hua; Wang, Li-li; Wu, Qin; Zhao, Guo-ming; Li, Song

2014-09-01

A series of novel Heteroaryldihydropyrimidines (HAPs) derivatives were designed and synthesized as potent inhibitors of HBV capsid assembly. These compounds were prepared from efforts to optimize an earlier series of HAPs, and compounds Mo1, Mo7, Mo8, Mo10, Mo12, and Mo13 demonstrated potent inhibition of HBV DNA replication at submicromolar range. Copyright © 2014. Published by Elsevier Ltd.

40 CFR Table 6 to Subpart Jjj of... - Known Organic HAP Emitted From the Production of Thermoplastic Products

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 11 2010-07-01 2010-07-01 true Known Organic HAP Emitted From the... HAP Emitted From the Production of Thermoplastic Products Thermoplastic product/Subcategory Organic HAP/chemical name(CAS No.) Acet-aldehyde (75-07-0) Acrylo-nitrile (107-13-1) 1,3 Buta-diene (106-99-0...

EXAMINING THE INFLAMMATORY RESPONSES OF HAPS: THE ROLE OF OZONE AND OTHER PHTOTCHEMICAL TRANSFORMATION PRODUCTS

Science.gov (United States)

The chemistry and health effects of individual hazardous air pollutants (HAPS) have been studied for many years. Once released into the atmosphere, HAPS interact with hydroxyl radicals and ozone (created by photochemical processes), to produce many different products, whose toxic...

40 CFR 63.1569 - What are my requirements for HAP emissions from bypass lines?

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 12 2010-07-01 2010-07-01 true What are my requirements for HAP emissions from bypass lines? 63.1569 Section 63.1569 Protection of Environment ENVIRONMENTAL PROTECTION... HAP emissions from bypass lines? (a) What work practice standards must I meet? (1) You must meet each...

Morphological and Structural Analysis of Nano-hydroxyapatite (n-hap) Coatings Electrodeposited on Titanium Substrate : Effect of Deposition Solution Concentration

International Nuclear Information System (INIS)

Nik Norziehana Che Isa; Norjanah Yury; Yusairie Mohd

2011-01-01

Various concentration of deposition solutions containing CaCl 2 and NH 4 H 2 PO 4 (with Ca/P ratio equal to 1.67) were used to study the effect of deposition solution concentration on the surface morphology and structure of Hydroxyapatite (HAp) coatings. Each HAp coating was deposited onto Ti substrate by applying a constant potential of 1.5 V (vs Ag/ AgCl) at 80 degree Celsius. The formation of HAp coatings was confirmed by FTIR and XRD analyses. Various morphologies consisting of HAp nanoparticles were produced from different deposition solutions as observed by SEM. The concentration of deposition solution has significantly affected the morphology of n-HAp coatings. (author)

40 CFR Table 3 to Subpart Pppp of... - Default Organic HAP Mass Fraction for Solvents and Solvent Blends

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 12 2010-07-01 2010-07-01 true Default Organic HAP Mass Fraction for... Organic HAP Mass Fraction for Solvents and Solvent Blends You may use the mass fraction values in the... solvent blend matches both the name and CAS number for an entry, that entry's organic HAP mass fraction...

Health Activities Project (HAP): Action/Reaction Module.

Science.gov (United States)

Buller, Dave; And Others

Contained within this Health Activities Project (HAP) learning packet are activities for children in grades 5-8. Design of the activities centers around the idea that students can control their own health and safety. Within this module are teacher and student folios describing activities in timing, improving, and practicing to improve reaction…

Health Activities Project (HAP), Trial Edition III.

Science.gov (United States)

Buller, Dave; And Others

Contained within this Health Activities Project (HAP) trial edition (set III) are a teacher information folio and numerous student activity folios which center around the idea that students in grades 5-8 can control their own health and safety. Each student folio is organized into an Overview, Health Background, Materials, Setting Up, and…

Streamlining cooperation between public authorities and civil society : Exclusive Baltinfo interview with Arnold Rüütel, president of Estonia and patron of the IV Baltic Sea NGO Forum in Pärnu 16-17 April / Arnold Rüütel

Index Scriptorium Estoniae

Rüütel, Arnold

2004-01-01

Intervjuu mittetulundusühingute seminari "IV BALTIC SEA NGO FORUM" patrooni Arnold Rüütliga kodanikeühenduste ja avaliku sektori koostööst, ühiskondlikust lepingust, 2002. aastal Riigikogus vastu võetud Eesti kodanikuühiskonna arengu kontseptsioonist

Achados cirúrgicos em 260 casos de impressão basilar e/ou malformação de Arnold-Chiari

Directory of Open Access Journals (Sweden)

José Alberto Gonçalves da Silva

1994-09-01

Full Text Available A impressão basilar é malformação frequentemente observada no Nordeste do Brasil. No período de 1971 a 1992 foram operados, em nosso Serviço, 260 pacientes com malformações occipitocervicais, sendo 29 (11,1% casos de impressão basilar pura, 18 (6,9% com malformação de Arnold-Chiari e 213 (81,9% com impressão basilar associada à malformação de Arnold-Chiari. São relatados os achados cirúrgicos do plano ósseo, da dura-máter, do tecido nervoso e dos vasos da fossa posterior.

40 CFR Table 3 to Subpart Mmmm of... - Default Organic HAP Mass Fraction for Solvents and Solvent Blends

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 12 2010-07-01 2010-07-01 true Default Organic HAP Mass Fraction for... Part 63—Default Organic HAP Mass Fraction for Solvents and Solvent Blends You may use the mass fraction.... If a solvent blend matches both the name and CAS number for an entry, that entry's organic HAP mass...

Channel modelling for free-space optical inter-HAP links using adaptive ARQ transmission

Science.gov (United States)

Parthasarathy, S.; Giggenbach, D.; Kirstädter, A.

2014-10-01

Free-space optical (FSO) communication systems have seen significant developments in recent years due to growing need for very high data rates and tap-proof communication. The operation of an FSO link is suited to diverse variety of applications such as satellites, High Altitude Platforms (HAPs), Unmanned Aerial Vehicles (UAVs), aircrafts, ground stations and other areas involving both civil and military situations. FSO communication systems face challenges due to different effects of the atmospheric channel. FSO channel primarily suffers from scintillation effects due to Index of Refraction Turbulence (IRT). In addition, acquisition and pointing becomes more difficult because of the high directivity of the transmitted beam: Miss-pointing of the transmitted beam and tracking errors at the receiver generate additional fading of the optical signal. High Altitude Platforms (HAPs) are quasi-stationary vehicles operating in the stratosphere. The slowly varying but precisely determined time-of-flight of the Inter-HAP channel adds to its characteristics. To propose a suitable ARQ scheme, proper theoretical understanding of the optical atmospheric propagation and modeling of a specific scenario FSO channel is required. In this paper, a bi-directional symmetrical Inter-HAP link has been selected and modeled. The Inter-HAP channel model is then investigated via simulations in terms of optical scintillation induced by IRT and in presence of pointing error. The performance characteristic of the model is then quantified in terms of fading statistics from which the Packet Error Probability (PEP) is calculated. Based on the PEP characteristics, we propose suitable ARQ schemes.

Microstructure and mechanical properties of Mg–HAP composites

Indian Academy of Sciences (India)

Administrator

tion of load bearing capacity and suitable mechanical and metallurgical properties. ... lity as compared to β-TCP in our body fluid (Kwon et al. 2003). The HAP ... steel crucible under the protection of gas mixture contain- ing SF6 and CO2.

President : olen sügavas mures / Arnold Rüütel ; interv. Toomas Sildam

Index Scriptorium Estoniae

Rüütel, Arnold, 1928-

2006-01-01

President Arnold Rüütel nendib, et oma uusaastaläkituses noorte probleemidest Eesti ühiskonnas kõneldes ei teadnud ta, et samad probleemid puudutavad teravalt ka ta oma tütretütreid. Lisa: Lossiskandaal. Vt. samas: Ihukaitsjad vaikivad Rüütli eraelust; Ingvar Bärenklau. Rüütli lapselapsed elavad Kadriorus juba aastaid; Arvamust avaldavad Andrus Ansip, Urmas Reinsalu, Andres Herkel, Ain Seppik, Jaanus Männik ja Ivari Padar

Health Activities Project (HAP): Breathing Fitness Module.

Science.gov (United States)

Buller, Dave; And Others

Contained within this Health Activities Project (HAP) learning packet are activities for children in grades 5-8. Design of the activities centers around the idea that students can control their own health and safety. Within this module are teacher and student folios describing four activities which involve students in learning how to measure their…

Health Activities Project (HAP), Trial Edition II.

Science.gov (United States)

Buller, Dave; And Others

Contained within this Health Activities Project (HAP) trial edition (set II) are a teacher information folio and numerous student activity folios which center around the idea that students in grades 5-8 can control their own health and safety. Each student folio is organized into a Synopsis, Health Background, Materials, Setting Up, and Activities…

Increased ethanol production by deletion of HAP4 in recombinant xylose-assimilating Saccharomyces cerevisiae.

Science.gov (United States)

Matsushika, Akinori; Hoshino, Tamotsu

2015-12-01

The Saccharomyces cerevisiae HAP4 gene encodes a transcription activator that plays a key role in controlling the expression of genes involved in mitochondrial respiration and reductive pathways. This work examines the effect of knockout of the HAP4 gene on aerobic ethanol production in a xylose-utilizing S. cerevisiae strain. A hap4-deleted recombinant yeast strain (B42-DHAP4) showed increased maximum concentration, production rate, and yield of ethanol compared with the reference strain MA-B42, irrespective of cultivation medium (glucose, xylose, or glucose/xylose mixtures). Notably, B42-DHAP4 was capable of producing ethanol from xylose as the sole carbon source under aerobic conditions, whereas no ethanol was produced by MA-B42. Moreover, the rate of ethanol production and ethanol yield (0.44 g/g) from the detoxified hydrolysate of wood chips was markedly improved in B42-DHAP4 compared to MA-B42. Thus, the results of this study support the view that deleting HAP4 in xylose-utilizing S. cerevisiae strains represents a useful strategy in ethanol production processes.

A Novel Image Encryption Based on Algebraic S-box and Arnold Transform

Science.gov (United States)

Farwa, Shabieh; Muhammad, Nazeer; Shah, Tariq; Ahmad, Sohail

2017-09-01

Recent study shows that substitution box (S-box) only cannot be reliably used in image encryption techniques. We, in this paper, propose a novel and secure image encryption scheme that utilizes the combined effect of an algebraic substitution box along with the scrambling effect of the Arnold transform. The underlying algorithm involves the application of S-box, which is the most imperative source to create confusion and diffusion in the data. The speciality of the proposed algorithm lies, firstly, in the high sensitivity of our S-box to the choice of the initial conditions which makes this S-box stronger than the chaos-based S-boxes as it saves computational labour by deploying a comparatively simple and direct approach based on the algebraic structure of the multiplicative cyclic group of the Galois field. Secondly the proposed method becomes more secure by considering a combination of S-box with certain number of iterations of the Arnold transform. The strength of the S-box is examined in terms of various performance indices such as nonlinearity, strict avalanche criterion, bit independence criterion, linear and differential approximation probabilities etc. We prove through the most significant techniques used for the statistical analyses of the encrypted image that our image encryption algorithm satisfies all the necessary criteria to be usefully and reliably implemented in image encryption applications.

Divergência, variabilidade genética e desempenho agronômico em genótipos de couve.

OpenAIRE

Azevedo, Alcinei Mistico

2012-01-01

Embora haja grande variabilidade genética para a couve, são poucos trabalhos no Brasil que visão obter informações para programas de melhoramento genético nesta cultura. Assim, objetivou-se neste trabalho caracterizar 30 genótipos de couve a partir de caracteres morfo-agronômicos para estimar a divergência genética, a importância dos caracteres para a divergência, o desempenho agronômico, os parâmetros genéticos e a correlação entre as características avaliadas. O experimento foi conduzido na...

40 CFR 63.1568 - What are my requirements for HAP emissions from sulfur recovery units?

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 12 2010-07-01 2010-07-01 true What are my requirements for HAP emissions from sulfur recovery units? 63.1568 Section 63.1568 Protection of Environment ENVIRONMENTAL... requirements for HAP emissions from sulfur recovery units? (a) What emission limitations and work practice...

Market share scenarios for Gen-DIII and gen-IV reactors in Europe

International Nuclear Information System (INIS)

Roelofs, F.; Heek, A. V.; Durpel, L. V. D.

2008-01-01

Nuclear energy is back on the agenda worldwide in order to meet growing energy demand and especially the growth in electricity demand. Many objectives direct to an increased use of nuclear energy, i.e. minimising energy costs, reducing climate change effects and others. In the light of the potential renewed growth of nuclear energy, the public demands a clear view on what nuclear energy may contribute towards meeting these objectives and especially how nuclear energy may address some socio-political obstructions with respect to economics, radioactive waste, safety and proliferation of fissile materials. To address these questions, the future nuclear reactor park mix in Europe has been analysed applying an integrated dynamic process modelling technique. Various market share scenarios for nuclear energy are derived including sub-variants with regard to the intra-nuclear options. In the analyses, it is assumed that different types of new reactors may be built, taking into account the introduction date of considered Gen-Ill (i.e. EPR) and Gen-IV (i.e. SCWR, HTR, FR) reactors, and the economic evaluation of the complete fuel cycle. The assessment was undertaken using the DANESS code (Dynamic Analysis of Nuclear Energy System Strategies). The analyses show that given the considered realistic nuclear energy demand and given a limited number of available Gen-III and Gen-IV reactor types, the future European nuclear park will exist of combinations of Gen-III and Gen-IV reactors. This mix will always consist of a set of reactor types each having its specific strengths. The analyses also highlight the triggers influencing the choice between different nuclear energy deployment scenarios. (authors)

The Babesia bovis hap2 gene is not required for blood stage replication, but expressed upon in vitro sexual stage induction

Science.gov (United States)

Hussein, Hala E.; Bastos, Reginaldo G.; Schneider, David A.; Johnson, Wendell C.; Adham, Fatma K.; Davis, William C.; Laughery, Jacob M.; Herndon, David R.; Alzan, Heba F.

2017-01-01

Babesia bovis, is a tick borne apicomplexan parasite responsible for important cattle losses globally. Babesia parasites have a complex life cycle including asexual replication in the mammalian host and sexual reproduction in the tick vector. Novel control strategies aimed at limiting transmission of the parasite are needed, but transmission blocking vaccine candidates remain undefined. Expression of HAP2 has been recognized as critical for the fertilization of parasites in the Babesia-related Plasmodium, and is a leading candidate for a transmission blocking vaccine against malaria. Hereby we identified the B. bovis hap2 gene and demonstrated that it is widely conserved and differentially transcribed during development within the tick midgut, but not by blood stage parasites. The hap2 gene was disrupted by transfecting B. bovis with a plasmid containing the flanking regions of the hap2 gene and the GPF-BSD gene under the control of the ef-1α-B promoter. Comparison of in vitro growth between a hap2-KO B. bovis clonal line and its parental wild type strain showed that HAP2 is not required for the development of B. bovis in erythrocytes. However, xanthurenic acid-in vitro induction experiments of sexual stages of parasites recovered after tick transmission resulted in surface expression of HAP2 exclusively in sexual stage induced parasites. In addition, hap2-KO parasites were not able to develop such sexual stages as defined both by morphology and by expression of the B. bovis sexual marker genes 6-Cys A and B. Together, the data strongly suggests that tick midgut stage differential expression of hap2 is associated with the development of B. bovis sexual forms. Overall these studies are consistent with a role of HAP2 in tick stages of the parasite and suggest that HAP2 is a potential candidate for a transmission blocking vaccine against bovine babesiosis. PMID:28985216

Presidendipaari avaldus / Rüütel Arnold, Ingrid Rüütel

Index Scriptorium Estoniae

Rüütel, Arnold, 1928-

2006-01-01

Ilmunud ka Postimees : na russkom jazõke (2006) 23. jaan., lk. 2 ; Eesti Päevaleht (2006) 23. jaan., lk. 6 ; SL Õhtuleht (2006) 23. jaan., lk. 2 ; Hiiu Leht (2006) 24. jaan., lk. 2 ; Harjumaa (2006) 24. jaan., lk. 1 ; Pärnu Postimees (2006) 24. jaan., lk. 19 ; Virumaa Teataja (2006) 24. jaan., lk. 7 ; Sakala (2006) 24. jaan., lk. 2 ; Võrumaa Teataja (2006) 24. jaan., lk. 2 ; Põhjarannik (2006) 24. jaan., lk. 2 ; Severnoje Poberezhje (2006) 24. jaan., lk. 2 ; Meie Maa (2006/) 24. jaan., lk. 2. President Arnold Rüütli ja proua Ingrid Rüütli avaldus seoses Kadrioru lossis toimunud noortepidudega

The C-Terminal Fragment of the Internal 110-Kilodalton Passenger Domain of the Hap Protein of Nontypeable Haemophilus influenzae Is a Potential Vaccine Candidate

OpenAIRE

Liu, Dai-Fang; Mason, Kathryn W.; Mastri, Maria; Pazirandeh, Mehran; Cutter, David; Fink, Doran L.; St. Geme, Joseph W.; Zhu, Duzhang; Green, Bruce A.

2004-01-01

Nontypeable Haemophilus influenzae is a major causative agent of bacterial otitis media in children. H. influenzae Hap autotransporter protein is an adhesin composed of an outer membrane Hapβ region and a moiety of an extracellular internal 110-kDa passenger domain called HapS. The HapS moiety promotes adherence to human epithelial cells and extracellular matrix proteins, and it also mediates bacterial aggregation and microcolony formation. A recent work (D. L. Fink, A. Z. Buscher, B. A. Gree...

Vladimir I Arnold - Collected Works Representations of Functions, Celestial Mechanics, and KAM Theory 1957-1965

CERN Document Server

Arnold, Vladimir I; Khesin, Boris

2010-01-01

Vladimir Arnold is one of the great mathematical scientists of our time. He is famous for both the breadth and the depth of his work. At the same time he is one of the most prolific and outstanding mathematical authors. This first volume of his Collected Works focuses on representations of functions, celestial mechanics, and KAM theory.

Quantum color image watermarking based on Arnold transformation and LSB steganography

Science.gov (United States)

Zhou, Ri-Gui; Hu, Wenwen; Fan, Ping; Luo, Gaofeng

In this paper, a quantum color image watermarking scheme is proposed through twice-scrambling of Arnold transformations and steganography of least significant bit (LSB). Both carrier image and watermark images are represented by the novel quantum representation of color digital images model (NCQI). The image sizes for carrier and watermark are assumed to be 2n×2n and 2n‑1×2n‑1, respectively. At first, the watermark is scrambled into a disordered form through image preprocessing technique of exchanging the image pixel position and altering the color information based on Arnold transforms, simultaneously. Then, the scrambled watermark with 2n‑1×2n‑1 image size and 24-qubit grayscale is further expanded to an image with size 2n×2n and 6-qubit grayscale using the nearest-neighbor interpolation method. Finally, the scrambled and expanded watermark is embedded into the carrier by steganography of LSB scheme, and a key image with 2n×2n size and 3-qubit information is generated at the meantime, which only can use the key image to retrieve the original watermark. The extraction of watermark is the reverse process of embedding, which is achieved by applying a sequence of operations in the reverse order. Simulation-based experimental results involving different carrier and watermark images (i.e. conventional or non-quantum) are simulated based on the classical computer’s MATLAB 2014b software, which illustrates that the present method has a good performance in terms of three items: visual quality, robustness and steganography capacity.

40 CFR Table 4 to Subpart Ppp of... - Known Organic HAP From Polyether Polyol Products

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 11 2010-07-01 2010-07-01 true Known Organic HAP From Polyether Polyol... CATEGORIES National Emission Standards for Hazardous Air Pollutant Emissions for Polyether Polyols Production Pt. 63, Subpt. PPP, Table 4 Table 4 to Subpart PPP of Part 63—Known Organic HAP From Polyether Polyol...

Characterization of derived natural hydroxyapatite (HAp) obtained from different types of tilapia fish bones and scales

Science.gov (United States)

Fara, A. N. K. A.; Abdullah, H. Z.

2015-07-01

Hydroxyapatite, (HAp), Ca10(PO4)6(OH)2, is recognised as a biomaterial that is widely used for bone implant due to its chemical and structural similarity to the mineral components in human bone and enamel. The elements of HAp are primarily composed of calcium and phosphorus molar ratio of calcium to phosphorous is 1.67 capable to promote bone in-growth into prosthetic implant. Enormous amounts of by-product waste produced from fish factories generated an undesirable environmental impact. Thus, this study was conducted to obtain natural biological HAp from different types of tilapia fish bones and scales from fishery waste. Therefore, fish bones and scales can be as cheap source to produce biological HAp for medical applications. For this purpose, fish bones and scales of tilapia fish were boiled at 100°C to remove adhering meat and other impurities. Later, fish bones and scales were separated into several groups and subjected to different calcination temperatures of 800° C and 900° C for 3h respectively. Afterward, all calcined samples were crushed to form a fine powder. The XRD result revealed the presence of derived Hapfrom the samples powder and were identical with standard Hap. Thermo Gravimetric Analysis was carried out to show the thermal stability of the HAp powder from different types of fish bones and scales. SEM results show porous structure appeared in calcined samples compared to raw samples. The findings are the promising alternative to produce calcium and phosphorus from fishery wastes that beneficial to medical applications.

CINR Performance of Downlink Mobile WiMAX IEEE 802.16e Deployed Using Coexistence Cellular Terrestrial and HAPS

Directory of Open Access Journals (Sweden)

I. Iskandar

2014-11-01

Full Text Available Deploying WiMAX through High Altitude Platform Station (HAPS system is a new means of wireless delivery method and thus attracting much the attention in a telecommunication society. However delivering WiMAX through the terrestrial network has already been started a few years ago. Therefore, we need to look at the scenario of coexistence system both of HAPS and terrestrial in delivering WiMAX services. This paper evaluates the performance of coexistence system between cellular HAPS and terrestrial for the downlink scenario when they are transmitting WiMAX mobile 802.16e services. Our evaluation is based on the performance simulation of coexistence model using two methods. First method is a footprint exchange between the two systems.The second method is a combination of footprint exchange and HAPS footprint enhancement. The proposed methodsare then evaluated by computer simulation in terms of carrier to interference plus noise ratio (CINR performance. In general, both methods resulting performance enhancement in CINR quality compared with coexistence deployment with normal scenario of the cell configuration used by HAPS and terrestrial. The method of combining footprint exchange and HAPS footprint enhancement is able to improve CINR more than 10 dB compared with the normal footprint configuration for all users location inside the coverage.

Electric field-assisted formation of organically modified hydroxyapatite (ormoHAP) spheres in carboxymethylated gelatin gels.

Science.gov (United States)

Heinemann, C; Heinemann, S; Kruppke, B; Worch, H; Thomas, J; Wiesmann, H P; Hanke, T

2016-10-15

A biomimetic strategy was developed in order to prepare organically modified hydroxyapatite (ormoHAP) with spherical shape. The technical approach is based on electric field-assisted migration of calcium ions and phosphate ions into a hydrogel composed of carboxymethylated gelatin. The electric field as well as the carboxymethylation using glucuronic acid (GlcA) significantly accelerates the mineralization process, which makes the process feasible for lab scale production of ormoHAP spheres and probably beyond. A further process was developed for gentle separation of the ormoHAP spheres from the gelatin gel without compromising the morphology of the mineral. The term ormoHAP was chosen since morphological analyses using electron microscopy (SEM, TEM) and element analysis (EDX, FT-IR, XRD) confirmed that carboxymethylated gelatin molecules use to act as organic templates for the formation of nanocrystalline HAP. The hydroxyapatite (HAP) crystals self-organize to form hollow spheres with diameters ranging from 100 to 500nm. The combination of the biocompatible chemical composition and the unique structure of the nanocomposites is considered to be a useful basis for future applications in functionalized degradable biomaterials. A novel bioinspired mineralization process was developed based on electric field-assisted migration of calcium and phosphate ions into biochemically carboxymethylated gelatin acting as organic template. Advantages over conventional hydroxyapatite include particle size distribution and homogeneity as well as achievable mechanical properties of relevant composites. Moreover, specifically developed calcium ion or phosphate ion release during degradation can be useful to adjust the fate of bone cells in order to manipulate remodeling processes. The hollow structure of the spheres can be useful for embedding drugs in the core, encapsulated by the highly mineralized outer shell. In this way, controlled drug release could be achieved, which enables

40 CFR Appendix: Table 1 to... - List of Hazardous Air Pollutants (HAP) for Subpart HHH

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 11 2010-07-01 2010-07-01 true List of Hazardous Air Pollutants (HAP) for Subpart HHH Table Appendix: Table 1 to Subpart HHH of Part 63 Protection of Environment... HHH of Part 63—List of Hazardous Air Pollutants (HAP) for Subpart HHH CAS Number a Chemical name 75070...

Investigation of Catalytic effect sewage sludge combustion ash in the formation of HAPs

Energy Technology Data Exchange (ETDEWEB)

Fullana, A.; Sidhu, S.; Font, R.; Conesa, A.

2002-07-01

Incineration is a very important technique in the treatment of sewage sludge. In 1998 approximately 1,5 million and 2,5 million dry tons of sewage sludge were incinerated in the United States and European Union (EU), respectively. In 1985, only 10% of EU sludge was incinerated, but by 2005 approximately 40% of EU sludge is expected to be incinerated. Use of sewage sludge as agricultural fertilizer was considered the best application for sludge until it was discovered that the presence of heavy metals in sludge could contaminate farmland. The limitations facing landfills and recycling plants and the planned ban on sea disposal has led to the expectation that the role of incineration will increase in the future. The expected increase in sludge incineration has also led to increased scrutiny of the main drawback to the incineration of sewage sludge: the formation of hazard air pollutants (HAP). Sewage sludge incineration has been identified as a very important source of HAPs such as chloro benzenes, chloro phenols, and PCDD/Fs. One of the more important characteristics of sewage sludge incineration is the formation of large amounts of ash, which is rich in known HAP formation catalysts such as Cu and Fe. Thus, the sludge incineration ash is expected to play an important role in the formation of HAPs in the post-combustion zone of a sludge incinerator. in this paper, we present results of our investigation of the catalytic effect of sewage sludge ash on the formation of chloro benzenes and chloro phenols. In this study, pyrolytic gas from sewage sludge was used as reaction gas instead of the synthetic organic mix that has been used in most previous HAPs formation studies. (Author) 4 refs.

The Babesia bovis hap2 gene is not required for blood stage replication, but expressed upon in vitro sexual stage induction.

Directory of Open Access Journals (Sweden)

Hala E Hussein

2017-10-01

Full Text Available Babesia bovis, is a tick borne apicomplexan parasite responsible for important cattle losses globally. Babesia parasites have a complex life cycle including asexual replication in the mammalian host and sexual reproduction in the tick vector. Novel control strategies aimed at limiting transmission of the parasite are needed, but transmission blocking vaccine candidates remain undefined. Expression of HAP2 has been recognized as critical for the fertilization of parasites in the Babesia-related Plasmodium, and is a leading candidate for a transmission blocking vaccine against malaria. Hereby we identified the B. bovis hap2 gene and demonstrated that it is widely conserved and differentially transcribed during development within the tick midgut, but not by blood stage parasites. The hap2 gene was disrupted by transfecting B. bovis with a plasmid containing the flanking regions of the hap2 gene and the GPF-BSD gene under the control of the ef-1α-B promoter. Comparison of in vitro growth between a hap2-KO B. bovis clonal line and its parental wild type strain showed that HAP2 is not required for the development of B. bovis in erythrocytes. However, xanthurenic acid-in vitro induction experiments of sexual stages of parasites recovered after tick transmission resulted in surface expression of HAP2 exclusively in sexual stage induced parasites. In addition, hap2-KO parasites were not able to develop such sexual stages as defined both by morphology and by expression of the B. bovis sexual marker genes 6-Cys A and B. Together, the data strongly suggests that tick midgut stage differential expression of hap2 is associated with the development of B. bovis sexual forms. Overall these studies are consistent with a role of HAP2 in tick stages of the parasite and suggest that HAP2 is a potential candidate for a transmission blocking vaccine against bovine babesiosis.

40 CFR 63.1566 - What are my requirements for organic HAP emissions from catalytic reforming units?

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 12 2010-07-01 2010-07-01 true What are my requirements for organic HAP emissions from catalytic reforming units? 63.1566 Section 63.1566 Protection of Environment... are my requirements for organic HAP emissions from catalytic reforming units? (a) What emission...

40 CFR 63.1567 - What are my requirements for inorganic HAP emissions from catalytic reforming units?

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 12 2010-07-01 2010-07-01 true What are my requirements for inorganic HAP emissions from catalytic reforming units? 63.1567 Section 63.1567 Protection of Environment... are my requirements for inorganic HAP emissions from catalytic reforming units? (a) What emission...

Arnold Rüütlile tuleb anda võimalus rääkida / Jarno Laur

Index Scriptorium Estoniae

Laur, Jarno, 1975-

2006-01-01

Autori arvates on ebaaus nii ametisoleva presidendi Arnold Rüütli, presidenti valivate saadikute ja volinike kui ka teiste presidendikandidaatide suhtes, et praegust presidenti pole sisulistesse debattidesse üldse kaasatud. Ta soovitab lisaks Rahvaliidu 16. allkirjale anda kõigil teistel parlamendierakondadel vähemalt üks allkiri president Rüütli toetuseks, et viimane saaks võimaluse rääkida ning osaleda valimiskampaanias teistega võrdsetel alustel

40 CFR Table 29 to Subpart Uuu of... - HAP Emission Limits for Sulfur Recovery Units

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 12 2010-07-01 2010-07-01 true HAP Emission Limits for Sulfur Recovery Units 29 Table 29 to Subpart UUU of Part 63 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... to Subpart UUU of Part 63—HAP Emission Limits for Sulfur Recovery Units As stated in § 63.1568(a)(1...

Liminality and Traces of Affectivity in the Work of Arnold van Gennep

DEFF Research Database (Denmark)

Thomassen, Bjørn

2013-01-01

Linking liminality with affectivity does not mean to propose new and alternative interpretations of what liminality is or could be, taking it to territories distant from its place of origin, quite the contrary: it means to move the concept back to its rightful place in intellectual history, back ...... to the centre of human emotions trembling at the threshold. This can best be indicated by tracing how affectivity was a theme in Arnold van Gennep’s (AvG) life-work, even if it was not a word he used....

Experimental Study on 3D Chi - Hap Scaffolds for Thyroid Cartilage Repairing

Science.gov (United States)

Sun, Nannan; Shi, Tingchun; Fan, Yuan; Hu, Binbin

2018-01-01

Due to the limitation of self-repairing capability for cartilage injury, the construction of tissue engineering in vitro has been an ideal treatment to repair tissue injury. In this paper, hydroxyapatite (Hap) and chitosan (Chi) were selected to fabricate the scaffold through low temperature deposition manufacturing (LDM) technique. The scaffold was characterized with interconnected structure and high porosity, as well as lower toxicity to cells (TDC-5-EGPE). Animal experiment was performed, Twelve white New Zealand rabbits were randomly divided into two groups, the side of the thyroid cartilage was removed, Chi-HAP composite scaffold was implanted into the cartilage defect as the experimental group A. Group B was treated for thyroid cartilage defects without any treatment. After 10 weeks, hematoxylin-eosin (HE) staining and S-O staining were carried out on the injured tissues. The result showed that newborn chondrocytes were found in repaired areas for group A, and there are no new cells found for group B. Therefore, Chi-HAP composite scaffolds formed by LDM possess biological activity for repairing injury cartilage.

All-optical two-way relaying free-space optical communications for HAP-based broadband backhaul networks

Science.gov (United States)

Vu, Minh Q.; Nguyen, Nga T. T.; Pham, Hien T. T.; Dang, Ngoc T.

2018-03-01

High-altitude platforms (HAPs) are flexible, non-pollutant and cost-effective infrastructures compared to satellite or old terrestrial systems. They are being researched and developed widely in Europe, USA, Japan, Korea, and so on. However, the current limited data rates and the overload of radio frequency (RF) spectrum are problems which the developers for HAPs are confronting because most of them use RF links to communicate with the ground stations (GSs) or each other. In this paper, we propose an all-optical two-way half-duplex relaying free-space optical (FSO) communication for HAP-based backhaul networks, which connect the base transceiver station (BTS) to the core network (CN) via a single HAP. Our proposed backhaul solution can be deployed quickly and flexibly for disaster relief and for serving users in both urban environments and remote areas. The key subsystem of HAP is an optical regenerate-and-forward (ORF) equipped with an optical hard-limiter (OHL) and an optical XOR gate to perform all-optical processing and help mitigate the background noise. In addition, two-way half-duplex relaying can be provided thanks to the use of network coding scheme. The closed-form expression for the bit error rate (BER) of our proposed system under the effect of path loss, atmospheric turbulence, and noise induced by the background light is formulated. The numerical results are demonstrated to prove the feasibility of our proposed system with the verification by using Monte-Carlo (M-C) simulations.

Health Activities Project (HAP): Sight and Sound Module.

Science.gov (United States)

Buller, Dave; And Others

Contained within this Health Activities Project (HAP) learning packet are activities for children in grades 5-8. Design of the activities centers around the idea that students can control their own health and safety. Within this module are teacher and student folios describing six activities which involve students in restricting their vision by…

Arnold Gesell's progressive vision: child hygiene, socialism and eugenics.

Science.gov (United States)

Harris, Ben

2011-08-01

In October 1913, The American Magazine published an article by Arnold Gesell that portrayed Alma, Wisconsin (his hometown) as overflowing with the mentally and morally unfit. In "The Village of a Thousand Souls", Gesell called for the observation and segregation of the unfit as a eugenic measure. This article explores the reasons behind this infamous article by someone who became a famous developmental psychologist and pediatrician. Gesell's papers at the Library of Congress reveal his socialist views of poverty, injustice, and human development. The archives of his father's photography studio at the Wisconsin Historical Society reveal his manipulation of the photographic record to fit his negative view of Alma. Typical of the era, Gesell's Progressive vision combined social control and negative eugenics with egalitarianism and the benevolent engineering of the environment.

Annual National Logistics Conference and Exhibition (26th) (BRIEFING CHARTS)

Science.gov (United States)

2010-04-15

Operations Division, Office of the Chief of Naval Operations (OPNAV N41) Luncheon Speaker · BrigGen Mike Dana , USMC, Director of Logistics...Speaker u BrigGen Mike Dana , USMC, Director of Logistics & Engineering, J4, NORAD and USNORTHCOM u Col Alex Vohr, USMC, Director of Logistics, J4...are the Core Elements of a Curriculum on Contemporary Strategy, and What are the Best Methods of Teaching Them? Dr Richard Betts, Arnold A. Saltzman

National Test and Evaluation Conference (26th)

Science.gov (United States)

2010-03-04

Operations Division, Office of the Chief of Naval Operations (OPNAV N41) Luncheon Speaker · BrigGen Mike Dana , USMC, Director of Logistics...Speaker u BrigGen Mike Dana , USMC, Director of Logistics & Engineering, J4, NORAD and USNORTHCOM u Col Alex Vohr, USMC, Director of Logistics, J4...are the Core Elements of a Curriculum on Contemporary Strategy, and What are the Best Methods of Teaching Them? Dr Richard Betts, Arnold A. Saltzman

Management of uncommon secondary trigeminal neuralgia related to a rare Arnold Chiari type I malformation

Directory of Open Access Journals (Sweden)

Zafar Ali Khan

2017-12-01

Full Text Available Background Trigeminal neuralgia (TN may sometimes present secondary to an intra-cranial cause. Arnold Chiari Malformation (ACM is downward herniation of the cerebellar tonsils through the foramen magnum that may be a cause of TN like pain in very rare cases. Aims The aim of this brief report is to suggest the proper management of uncommon secondary trigeminal neuralgia related to a rare Arnold Chiari type I malformation. Methods A male patient presented electric shock like stabbing pain on the right side of the face for more than ten years. The symptoms were typical of trigeminal neuralgia except that there was loss of corneal reflex on the right side and the patient also complained of gait & sleep disturbances. Complex and multilevel diagnosis was made. Results A multiplanar imaging through brain acquiring T1/T2W1 revealed ACM Type I Malformation with caudal displacement of cerebellar tonsils through foramen magnum. Conclusion Dental surgeons and oral and Maxillofacial Surgeons should exclude intra-cranial causes by Magnetic Resonance Imaging(MRI in patients of TN presenting with loss of corneal reflex, gait and sleep disturbances due to night time pain episodes.

Kas Arnold Rüütel valetas süümevannet andes? / Anneli Ammas, Garel Püüa

Index Scriptorium Estoniae

Ammas, Anneli, 1962-

2006-01-01

Autorite hinnangul tekib 31. augustil Eesti Ekspressis ilmunud artikli põhjal, milles käsitleti Johannes Hindi represseerimist, küsimus, kas Arnold Rüütel on valetanud Eesti Vabariigile korduvalt süümevannet andes. TÜ professori Kalle Meruski seisukoht. Lisa: Rüütel käskis kontrolli tugevdada

President Arnold Rüütel andis president George W. H. Bushile üle Maarjamaa Risti / Kärt Ulman

Index Scriptorium Estoniae

Ulman, Kärt

2005-01-01

President Arnold Rüütel andis New Yorgis endisele USA presidendile Georg Bushile Eesti iseseisvuspüüdluste toetamise eest Maarjamaa Risti I klassi ordeni. Vt. samas lühiintervjuud president George W. H. Bushiga. Töövisiit New Yorki 13.-17.09.2005

40 CFR Table 22 to Subpart Uuu of... - Inorganic HAP Emission Limits for Catalytic Reforming Units

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 12 2010-07-01 2010-07-01 true Inorganic HAP Emission Limits for Catalytic Reforming Units 22 Table 22 to Subpart UUU of Part 63 Protection of Environment ENVIRONMENTAL..., Table 22 Table 22 to Subpart UUU of Part 63—Inorganic HAP Emission Limits for Catalytic Reforming Units...

40 CFR Table 8 to Subpart Uuu of... - Organic HAP Emission Limits for Catalytic Cracking Units

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 12 2010-07-01 2010-07-01 true Organic HAP Emission Limits for Catalytic Cracking Units 8 Table 8 to Subpart UUU of Part 63 Protection of Environment ENVIRONMENTAL..., Table 8 Table 8 to Subpart UUU of Part 63—Organic HAP Emission Limits for Catalytic Cracking Units As...

40 CFR Table 15 to Subpart Uuu of... - Organic HAP Emission Limits for Catalytic Reforming Units

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 12 2010-07-01 2010-07-01 true Organic HAP Emission Limits for Catalytic Reforming Units 15 Table 15 to Subpart UUU of Part 63 Protection of Environment ENVIRONMENTAL..., Table 15 Table 15 to Subpart UUU of Part 63—Organic HAP Emission Limits for Catalytic Reforming Units As...

Disease: H01561 [KEGG MEDICUS

Lifescience Database Archive (English)

Full Text Available RS ... Grazzi L, Andrasik F ... TITLE ... Headaches and Arnold-Chiari syndrome: when to suspect and how to inves...tigate. ... JOURNAL ... Curr Pain Headache Rep 16:350-3 (2012) DOI:10.1007/s11916-012-0270-2 ... PMID:25653995 (gen

Hemiplegia cruzada associada a impressão basilar, malformação de Arnold-Chiari e siringomielia: relato de caso Cruciate hemiplegia associated with basilar impression, Arnold-Chiari malformation and syringomyelia: case report

Directory of Open Access Journals (Sweden)

José Alberto Gonçalves da Silva

1996-12-01

Full Text Available Os autores apresentam um caso de hemiplegia cruzada associada a impressão basilar, malformação de Arnold-Chiari e siringomielia. Discutem as propostas anatômicas e a fiopatogenia desta síndrome de ocorrência bastante rara.The authors report a case of cruciate hemiplegia associated with basilar impression, Chiari malformation and syringomyelia. The neuroanatomical controversy, the surgical treatment and the good outcome of the patient are discussed.

GenLab, Laboratorio Virtual de Genética

Directory of Open Access Journals (Sweden)

Fidel Ramírez

2000-07-01

Full Text Available GenLab es el nombre que tiene el software diseñado por nosotros, en el cual se modela el proceso meiótico y la fecundación en organismos diploides. El objetivo de esta aplicación es ilustrar el resultado de un cruce determinado, tratando de ser lo más ajustados a la realidad. La modelación de la reproducción sexual se realiza internamente y el GenLab se limita a presentar los resultados según el número de descendencia seleccionado para un cruce específico, esto significa que se puede escoger una gran cantidad de características para los parentales y se puede estudiar la frecuencia de estos en la descendencia. El modelo cuenta con base de datos donde están almacenados algunos de los locus de Drosophila melanogaster junto con su ubicación en centimorgans 1. EI propósito de este modelo es servir como herramienta pedagógica  y didáctica tanto en universidades como en colegios, facilitando el aprendizaje de algunos principios básicos de la genética, por lo cual puede ser usado si se cuenta con una conexión a Internet y un navegador visitando http://biologia.unal.edu.co/fidel.

Use of a crossed high alcohol preferring (cHAP) mouse model with the NIAAA-model of chronic-binge ethanol intake to study liver injury.

Science.gov (United States)

Thompson, Kyle J; Nazari, Shayan S; Jacobs, W Carl; Grahame, Nicholas J; McKillop, Iain H

2017-11-01

This study sought to compare mice bred to preferentially consume high amounts of alcohol (crossed-high alcohol preferring, cHAP) to c57BL/6 (C57) mice using a chronic-binge ethanol ingestion model to induce alcoholic liver disease (ALD). Male C57 and cHAP mice were randomized to a Lieber-DeCarli control (LDC) diet, Lieber-DeCarli 5% (v/v) ethanol (LDE) diet or free-choice between 10% (v/v) ethanol in drinking water (EtOH-DW) and DW. After 4 weeks mice were gavaged with either 9 g/kg maltose-dextrin (LDC+MD) or 5 g/kg EtOH (LDE+Binge, EtOH-DW+Binge). Nine hours later tissue and serum were collected and analyzed. cHAP mice on EtOH-DW consumed significantly more ethanol than cHAP or C57 mice maintained on LDE. However, cHAP and C57 mice on the LDE+Binge regiment had greater hepatosteatosis and overall degree of liver injury compared to EtOH-DW+Binge. Changes in pro-inflammatory gene expression was more pronounced in cHAP mice than C57 mice. Analysis of liver enzymes revealed a robust induction of CYP2E1 in C57 and cHAP mice maintained on EtOH-DW+Binge or LDE+Binge. However, while C57 mice exhibited higher basal hepatic glutathione than cHAP mice, these mice appeared more susceptible to oxidative stress following LDE+Binge than cHAP counterparts. Despite cHAP mice consuming more total ethanol prior to gavage when maintained on EtOH-DW, LDE followed by gavage created a more severe model of ALD in both C57 and cHAP mice. These data suggest factors other than total amount of alcohol consumed affect degree of ALD development in the chronic-binge model in cHAP mice. cHAP mice voluntarily consume high amounts of ethanol and exhibited hepatic injury when subject to chronic-binge ethanol feeding with the Lieber-DeCarli diet. However, hepatic injury was reduced in cHAP mice in a chronic-binge model following voluntary high ethanol consumption in drinking water. © The Author 2017. Medical Council on Alcohol and Oxford University Press. All rights reserved.

40 CFR Table 1 to Subpart Uuu of... - Metal HAP Emission Limits for Catalytic Cracking Units

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 12 2010-07-01 2010-07-01 true Metal HAP Emission Limits for Catalytic Cracking Units 1 Table 1 to Subpart UUU of Part 63 Protection of Environment ENVIRONMENTAL PROTECTION... Table 1 to Subpart UUU of Part 63—Metal HAP Emission Limits for Catalytic Cracking Units As stated in...

HapX-Mediated Iron Homeostasis Is Essential for Rhizosphere Competence and Virulence of the Soilborne Pathogen Fusarium oxysporum[C][W][OA

Science.gov (United States)

López-Berges, Manuel S.; Capilla, Javier; Turrà, David; Schafferer, Lukas; Matthijs, Sandra; Jöchl, Christoph; Cornelis, Pierre; Guarro, Josep; Haas, Hubertus; Di Pietro, Antonio

2012-01-01

Soilborne fungal pathogens cause devastating yield losses and are highly persistent and difficult to control. During the infection process, these organisms must cope with limited availability of iron. Here we show that the bZIP protein HapX functions as a key regulator of iron homeostasis and virulence in the vascular wilt fungus Fusarium oxysporum. Deletion of hapX does not affect iron uptake but causes derepression of genes involved in iron-consuming pathways, leading to impaired growth under iron-depleted conditions. F. oxysporum strains lacking HapX are reduced in their capacity to invade and kill tomato (Solanum lycopersicum) plants and immunodepressed mice. The virulence defect of ΔhapX on tomato plants is exacerbated by coinoculation of roots with a biocontrol strain of Pseudomonas putida, but not with a siderophore-deficient mutant, indicating that HapX contributes to iron competition of F. oxysporum in the tomato rhizosphere. These results establish a conserved role for HapX-mediated iron homeostasis in fungal infection of plants and mammals. PMID:22968717

Seleção de genótipos parentais de acerola com base na divergência genética multivariada

Directory of Open Access Journals (Sweden)

CARPENTIERI-PÍPOLO VALÉRIA

2000-01-01

Full Text Available Este trabalho teve por objetivo identificar e selecionar genótipos parentais de acerola (Malpighia emarginata L. adequadas a programas de melhoramento genético. Nove caracteres quantitativos de maior importância agronômica foram usados para determinação da distância genética e formação de grupos similares de acessos. O agrupamento pelo método de Tocher, a partir das distâncias generalizadas de Mahalanobis, possibilitou a divisão de 14 genótipos em três grupos. Com base na divergência genética e no caráter agronômico-chave (teor de vitamina C, destacaram-se como mais promissores os cruzamentos dos genótipos: AM Mole pertencente ao grupo III, com os genótipos PR AM, N° 18, PR 17, PR 16, Eclipse, AM 22 e Dominga, todos pertencentes ao grupo I.

Augmentation of Quasi-Zenith Satellite Positioning System Using High Altitude Platforms Systems (HAPS)

Science.gov (United States)

Tsujii, Toshiaki; Harigae, Masatoshi

Recently, some feasibility studies on a regional positioning system using the quasi-zenith satellites and the geostationary satellites have been conducted in Japan. However, the geometry of this system seems to be unsatisfactory in terms of the positioning accuracy in north-south direction. In this paper, an augmented satellite positioning system by the High Altitude Platform Systems (HAPS) is proposed since the flexibility of the HAPS location is effective to improve the geometry of satellite positioning system. The improved positioning performance of the augmented system is also demonstrated.

Association of HTLV-I with Arnold Chiari syndrome and syringomyelia

Directory of Open Access Journals (Sweden)

Graça Maria de Castro Viana

Full Text Available HTLV-I is associated with a broad spectrum of manifestations, including tropical spastic paraparesis and adult T-cell leukemia/lymphoma. Arnold Chiari syndrome is a condition characterized by herniation of the cerebellar tonsils through the foramen magnum. This condition should be suspected in all patients with headache and impaired motor coordination. Syringomyelia is a developmental anomaly that leads to the formation of an intramedullary cavity. Its clinical presentation is classically characterized by syringomyelic dissociation of sensation, with suspended distribution in the proximal portion of the trunk and upper limbs and preservation in other regions. We report here a case of association of the three diseases, which is rare in clinical practice, illustrating the difficulty in the diagnosis and therapeutic management of these conditions.

Age at onset in Huntington's disease: replication study on the association of HAP1.

Science.gov (United States)

Karadima, Georgia; Dimovasili, Christina; Koutsis, Georgios; Vassilopoulos, Demetris; Panas, Marios

2012-11-01

In recent years two association studies investigating the HAP1 T441M (rs4523977) polymorphism as a potential modifying factor of the age at onset (AAO) of Huntington's disease (HD), have been reported. Initially evidence for association was found between the M441 risk allele and the AAO. Subsequently, a second study, although failing to replicate these findings, found evidence for association between the same risk allele and AAO of motor symptoms (mAAO). In the present study, the role of the HAP1 T441M polymorphism as a modifier of the AAO in HD was investigated in a cohort of 298 Greek HD patients. In this cohort the CAG repeat number accounted for 55% of the variance in AAO. No association was found between the HAP1 T441M polymorphism and the AAO of HD. © 2012 Elsevier Ltd. All rights reserved.

40 CFR 63.8055 - How do I comply with a weight percent HAP limit in coating products?

Science.gov (United States)

2010-07-01

... HAP limit in coating products? 63.8055 Section 63.8055 Protection of Environment ENVIRONMENTAL...: Miscellaneous Coating Manufacturing Alternative Means of Compliance § 63.8055 How do I comply with a weight percent HAP limit in coating products? (a) As an alternative to complying with the requirements in Table 1...

DEMONSTRATION OF NO-VOC/NO-HAP WOOD FURNITURE COATING SYSTEM

Science.gov (United States)

The United States Environmental Protection Agency has contracted with AeroVironment Environmental Services, Inc. and its subcontractor, Adhesives Coating Co., to develop and demonstrate a no-VOC (volatile organic compound)/no-HAP (hazardous air pollutant) wood furniture coating s...

Evidence on How a Conserved Glycine in the Hinge Region of HapR Regulates Its DNA Binding Ability: LESSONS FROM A NATURAL VARIANT.

Energy Technology Data Exchange (ETDEWEB)

M Dongre; N Singh; C Dureja; N Peddada; A Solanki; F Ashish; S Raychaudhuri

2011-12-31

HapR has been recognized as a quorum-sensing master regulator in Vibrio cholerae. Because it controls a plethora of disparate cellular events, the absence of a functional HapR affects the physiology of V. cholerae to a great extent. In the current study, we pursued an understanding of an observation of a natural protease-deficient non-O1, non-O139 variant V. cholerae strain V2. Intriguingly, a nonfunctional HapR (henceforth designated as HapRV2) harboring a substitution of glycine to aspartate at position 39 of the N-terminal hinge region has been identified. An in vitro gel shift assay clearly suggested the inability of HapRV2 to interact with various cognate promoters. Reinstatement of glycine at position 39 restores DNA binding ability of HapRV2 (HapRV2G), thereby rescuing the protease-negative phenotype of this strain. The elution profile of HapRV2 and HapRV2G proteins in size-exclusion chromatography and their circular dichroism spectra did not reflect any significant differences to explain the functional discrepancies between the two proteins. To gain insight into the structure-function relationship of these two proteins, we acquired small/wide angle x-ray scattering data from samples of the native and G39D mutant. Although Guinier analysis and indirect Fourier transformation of scattering indicated only a slight difference in the shape parameters, structure reconstruction using dummy amino acids concluded that although HapR adopts a 'Y' shape similar to its crystal structure, the G39D mutation in hinge drastically altered the DNA binding domains by bringing them in close proximity. This altered spatial orientation of the helix-turn-helix domains in this natural variant provides the first structural evidence on the functional role of the hinge region in quorum sensing-related DNA-binding regulatory proteins of Vibrio spp.

Nanomechanical properties of hydroxyapatite (HAP) with DAB dendrimers (poly-propylene imine) coatings onto titanium surfaces

International Nuclear Information System (INIS)

Charitidis, Costas A.; Skarmoutsou, Amalia; Tsetsekou, Athena; Brasinika, Despina; Tsiourvas, Dimitris

2013-01-01

Highlights: ► The synthesis of hydroxyapatite (HAP) nanoparticles in the presence of a cationic fourth generation diaminobutane poly(propylene imine) dendrimer (DAB). ► The nanomechanical properties of different HAP-DAB coatings onto titanium surfaces. ► Wear resistance and adhesion properties of the synthesized coatings quantified by nanoindentation data analysis. -- Abstract: Coatings of hydroxyapatite (HAP) nanorods onto titanium surfaces were synthesized with the aim to improve coatings’ mechanical properties and adhesion to the substrate. The coatings are consisting of HAP nanorods synthesized in the presence of a cationic fourth generation diaminobutane poly(propylene imine) dendrimer (DAB) bearing 32 amine end groups employing varying calcium: dendrimer ratios and varying hydrothermal treatments. The quality, surface morphology and structure of the coatings were characterized with X-ray diffraction, thermogravimetric analysis, scanning electron microscopy and energy dispersive microanalysis. Wear resistance and adhesion properties of the coatings onto titanium substrates were studied through nanoindentation analysis. The experimental conditions, namely the calcium: dendrimer molar ratio and the hydrothermal treatment temperature were carefully selected; thus, it was possible to produce coatings of high hardness and elastic modulus values (ranging between 1–4.5 GPa and 40–150 GPa, respectively) and/or high wear resistance and plastic deformation values

Nanomechanical properties of hydroxyapatite (HAP) with DAB dendrimers (poly-propylene imine) coatings onto titanium surfaces

Energy Technology Data Exchange (ETDEWEB)

Charitidis, Costas A., E-mail: charitidis@chemeng.ntua.gr [School of Chemical Engineering, National Technical University of Athens, Iroon Polytechniou, Zografou, 15780 Athens (Greece); Skarmoutsou, Amalia [School of Chemical Engineering, National Technical University of Athens, Iroon Polytechniou, Zografou, 15780 Athens (Greece); Tsetsekou, Athena; Brasinika, Despina [School of Mining Engineering and Metallurgy, National Technical University of Athens, Iroon Polytechniou, Zografou, 15780 Athens (Greece); Tsiourvas, Dimitris [National Centre for Scientific Research “Demokritos”, Institute of Physical Chemistry, Agia Paraskevi, 15310 Athens (Greece)

2013-04-20

Highlights: ► The synthesis of hydroxyapatite (HAP) nanoparticles in the presence of a cationic fourth generation diaminobutane poly(propylene imine) dendrimer (DAB). ► The nanomechanical properties of different HAP-DAB coatings onto titanium surfaces. ► Wear resistance and adhesion properties of the synthesized coatings quantified by nanoindentation data analysis. -- Abstract: Coatings of hydroxyapatite (HAP) nanorods onto titanium surfaces were synthesized with the aim to improve coatings’ mechanical properties and adhesion to the substrate. The coatings are consisting of HAP nanorods synthesized in the presence of a cationic fourth generation diaminobutane poly(propylene imine) dendrimer (DAB) bearing 32 amine end groups employing varying calcium: dendrimer ratios and varying hydrothermal treatments. The quality, surface morphology and structure of the coatings were characterized with X-ray diffraction, thermogravimetric analysis, scanning electron microscopy and energy dispersive microanalysis. Wear resistance and adhesion properties of the coatings onto titanium substrates were studied through nanoindentation analysis. The experimental conditions, namely the calcium: dendrimer molar ratio and the hydrothermal treatment temperature were carefully selected; thus, it was possible to produce coatings of high hardness and elastic modulus values (ranging between 1–4.5 GPa and 40–150 GPa, respectively) and/or high wear resistance and plastic deformation values.

Suggestibility, expectancy, trance state effects, and hypnotic depth: II. Assessment via the PCI-HAP.

Science.gov (United States)

Pekala, Ronald J; Kumar, V K; Maurer, Ronald; Elliott-Carter, Nancy; Moon, Edward; Mullen, Karen

2010-04-01

This study sought to determine if self-reported hypnotic depth (srHD) could be predicted from the variables of the Phenomenology of Consciousness Inventory - Hypnotic Assessment Procedure (PCI-HAP) (Pekala, 1995a, 1995b; Pekala & Kumar, 2007; Pekala et al., 2010), assessing several of the processes theorized by researchers to be associated with hypnotism: trance (altered state effects), suggestibility, and expectancy. One hundred and eighty participants completed the PCI-HAP. Using regression analyses, srHD scores were predicted from the PCI-HAP pre-hypnotic and post-hypnotic assessment items, and several other variables. The results suggested that the srHD scores were found to be a function of imagoic suggestibility, expectancy (both estimated hypnotic depth and expected therapeutic efficacy), and trance state and eye catalepsy effects; effects that appear to be additive and not (statistically) interactive. The results support the theorizing of many investigators concerning the involvement of the aforementioned component processes with this particular aspect of hypnotism, the self-reported hypnotic depth score.

Pühapäeval toimub kunstihoones esimene JazziMaali võistlus

Index Scriptorium Estoniae

2008-01-01

Rahvusvahelise dzhässikuu raames toimub Tallinna Kunstihoones JazziMaali pühapäev, kus musitseerib Estonian Guitar Octet ning maalivad Pelgulinna gümnaasiumi, Tallinna kunstikooli ja Sally Stuudio õpilased

Influence of HAp on the polymerization processes of a possible radioactive bone cement

Energy Technology Data Exchange (ETDEWEB)

Montaño, Carlos J.; Campos, Tarcísio P.R., E-mail: carlmont@ucm.es, E-mail: tprcampos@yahoo.com.br [Universidade Federal de Minas Gerais (UFMG), Belo Horizonte (Brazil). Dept. de Engenharia Nuclear. Lab. de Radiações Ionizantes; Silva, Adolfo H.M.; Araujo, Maria H., E-mail: adolfohmoraes@ufmg.br, E-mail: mharaujo1993@gmail.com [Universidade Federal de Minas Gerais (RMN/UFMG), Belo Horizonte (Brazil). Dept. de Ressonância Magnética Nuclear

2017-07-01

Polymethylmethacrylate PMMA is an acrylic that has been already proposed as a composite to adhere together the fractured bone structures. Subsequently, augmentation bone cements have incorporated Calcium Biophosphonates as vital part of its components to increase the biocompatibility with osseous tissues. Minimally invasive percutaneous techniques such as Vertebroplasty and Kyphoplasty have been developed to reduce surgical impact on patients, but in turn have been reported undesirable effects as extravasation of the cement outside of the planning target volume due to the compression of the internal bone fluids or other tissues. An in situ variable that helps favoring of the PMMA polymerization process is the temperature; however, it may bring deleterious effects. On the methodology, an assay was addressed varying the Hydroxyapatite HAp concentration. Also the cement processing was modified by setting water as a vehicle for particle dispersion. The ratios of HAp/PMMA concentrations were: 0.00000, 0.02167, 0.09062, 0.16619 and 0.50000 mixed in PMMA and liquid catalyst and monomer. The thermal profiles were measured during polymerization and analyzed. Nuclear magnetic resonance NMR analysis was carried out on the polymerization process in an aqueous state to monitor the H-H{sub 2}O proton signal. As results, an increasing in the cement hardness time was found in the proportion of the HAp concentration. The highest τ polymerization time was found for the x{sub 5} concentration and the signal from the water trapped in the HAp amorphous lattice was determined around ∼5 ppm in the {sup 1}H NMR spectra. (author)

Influence of HAp on the polymerization processes of a possible radioactive bone cement

International Nuclear Information System (INIS)

Montaño, Carlos J.; Campos, Tarcísio P.R.; Silva, Adolfo H.M.; Araujo, Maria H.

2017-01-01

Polymethylmethacrylate PMMA is an acrylic that has been already proposed as a composite to adhere together the fractured bone structures. Subsequently, augmentation bone cements have incorporated Calcium Biophosphonates as vital part of its components to increase the biocompatibility with osseous tissues. Minimally invasive percutaneous techniques such as Vertebroplasty and Kyphoplasty have been developed to reduce surgical impact on patients, but in turn have been reported undesirable effects as extravasation of the cement outside of the planning target volume due to the compression of the internal bone fluids or other tissues. An in situ variable that helps favoring of the PMMA polymerization process is the temperature; however, it may bring deleterious effects. On the methodology, an assay was addressed varying the Hydroxyapatite HAp concentration. Also the cement processing was modified by setting water as a vehicle for particle dispersion. The ratios of HAp/PMMA concentrations were: 0.00000, 0.02167, 0.09062, 0.16619 and 0.50000 mixed in PMMA and liquid catalyst and monomer. The thermal profiles were measured during polymerization and analyzed. Nuclear magnetic resonance NMR analysis was carried out on the polymerization process in an aqueous state to monitor the H-H 2 O proton signal. As results, an increasing in the cement hardness time was found in the proportion of the HAp concentration. The highest τ polymerization time was found for the x 5 concentration and the signal from the water trapped in the HAp amorphous lattice was determined around ∼5 ppm in the 1 H NMR spectra. (author)

40 CFR Table 30 to Subpart Uuu of... - Operating Limits for HAP Emissions From Sulfur Recovery Units

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 12 2010-07-01 2010-07-01 true Operating Limits for HAP Emissions From Sulfur Recovery Units 30 Table 30 to Subpart UUU of Part 63 Protection of Environment ENVIRONMENTAL..., Table 30 Table 30 to Subpart UUU of Part 63—Operating Limits for HAP Emissions From Sulfur Recovery...

Evolution of the paralogous hap and iga genes in Haemophilus influenzae: evidence for a conserved hap pseudogene associated with microcolony formation in the recently diverged Haemophilus aegyptius and H. influenzae biogroup aegyptius

DEFF Research Database (Denmark)

Kilian, Mogens; Poulsen, Knud; Lomholt, Hans Bredsted

2002-01-01

genetic polymorphism and pronounced mosaic-like patterns in both genes, but no evidence of intrastrain recombination between the two genes. A conserved hap pseudogene was present in all strains of H. aegyptius and H. influenzae biogroup aegyptius, each of which constituted distinct subpopulations...... on conjunctival cells, previously termed microcolony formation. The fact that individual hap pseudogenes differed from the ancestral sequence by zero to two positions within a 1.5 kb stretch suggests that the silencing event happened approximately 2000-11,000 years ago. Divergence of H. aegyptius and H...

Crystal structure of the Haemophilus influenzae Hap adhesin reveals an intercellular oligomerization mechanism for bacterial aggregation

Science.gov (United States)

Meng, Guoyu; Spahich, Nicole; Kenjale, Roma; Waksman, Gabriel; St Geme, Joseph W

2011-01-01

Bacterial biofilms are complex microbial communities that are common in nature and are being recognized increasingly as an important determinant of bacterial virulence. However, the structural determinants of bacterial aggregation and eventual biofilm formation have been poorly defined. In Gram-negative bacteria, a major subgroup of extracellular proteins called self-associating autotransporters (SAATs) can mediate cell–cell adhesion and facilitate biofilm formation. In this study, we used the Haemophilus influenzae Hap autotransporter as a prototype SAAT to understand how bacteria associate with each other. The crystal structure of the H. influenzae HapS passenger domain (harbouring the SAAT domain) was determined to 2.2 Å by X-ray crystallography, revealing an unprecedented intercellular oligomerization mechanism for cell–cell interaction. The C-terminal SAAT domain folds into a triangular-prism-like structure that can mediate Hap–Hap dimerization and higher degrees of multimerization through its F1–F2 edge and F2 face. The intercellular multimerization can give rise to massive buried surfaces that are required for overcoming the repulsive force between cells, leading to bacterial cell–cell interaction and formation of complex microcolonies. PMID:21841773

Improvement of the mechanical properties of spark plasma sintered hap bioceramics by decreasing the grain size and by adding multi-walled carbon nanotubes

Directory of Open Access Journals (Sweden)

Veljović Đ.

2013-01-01

Full Text Available Composites based on HAP and oxidized multi-walled carbon nanotubes (o-MWCNT and monophase HAP materials were processed by spark plasma sintering. Starting from stoichiometric nano-sized HAP powder, monophase bioceramics were obtained with a density close to the theoretical one and with an average grain size of several hundred nanometers to micron dimensions. It was shown that decreasing the sintering temperature resulted in a decrease of the grain size, which affected an increase in the fracture toughness and hardness. The fracture toughness of an HAP/ o-MWCNT bioceramic processed at 900°C for only 5 min was 30 % higher than that of monophase HAP materials obtained under the same conditions. The addition of MWCNT during SPS processing of HAP materials caused a decrease in the grain size to the nano-dimension, which was one of the reasons for the improved mechanical properties. [Projekat Ministarstva nauke Republike Srbije, br. III45019 i FP7-REGPOT-2009-1 NANOTECH FTM, Grant Agreement Number: 245916

Health Activities Project (HAP): Heart Fitness and Action Module.

Science.gov (United States)

Buller, Dave; And Others

Contained within this Health Activities Project (HAP) learning packet are activities for children in grades 5-8. Design of the activities centers around the idea that students can control their own health and safety. Within the Heart Fitness and Action Module are teacher and student folios describing five activities which involve students in…

40 CFR Table 36 to Subpart Uuu of... - Work Practice Standards for HAP Emissions From Bypass Lines

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 12 2010-07-01 2010-07-01 true Work Practice Standards for HAP Emissions From Bypass Lines 36 Table 36 to Subpart UUU of Part 63 Protection of Environment ENVIRONMENTAL..., Table 36 Table 36 to Subpart UUU of Part 63—Work Practice Standards for HAP Emissions From Bypass Lines...

"Tangible as tissue": Arnold Gesell, infant behavior, and film analysis.

Science.gov (United States)

Curtis, Scott

2011-09-01

From 1924 to 1948, developmental psychologist Arnold Gesell regularly used photographic and motion picture technologies to collect data on infant behavior. The film camera, he said, records behavior "in such coherent, authentic and measurable detail that ... the reaction patterns of infant and child become almost as tangible as tissue." This essay places his faith in the fidelity and tangibility of film, as well as his use of film as evidence, in the context of developmental psychology's professed need for legitimately scientific observational techniques. It also examines his use of these same films as educational material to promote his brand of scientific child rearing. But his analytic techniques - his methods of extracting data from the film frames - are the key to understanding the complex relationship between his theories of development and his chosen research technology.

Optical image encryption using multilevel Arnold transform and noninterferometric imaging

Science.gov (United States)

Chen, Wen; Chen, Xudong

2011-11-01

Information security has attracted much current attention due to the rapid development of modern technologies, such as computer and internet. We propose a novel method for optical image encryption using multilevel Arnold transform and rotatable-phase-mask noninterferometric imaging. An optical image encryption scheme is developed in the gyrator transform domain, and one phase-only mask (i.e., phase grating) is rotated and updated during image encryption. For the decryption, an iterative retrieval algorithm is proposed to extract high-quality plaintexts. Conventional encoding methods (such as digital holography) have been proven vulnerably to the attacks, and the proposed optical encoding scheme can effectively eliminate security deficiency and significantly enhance cryptosystem security. The proposed strategy based on the rotatable phase-only mask can provide a new alternative for data/image encryption in the noninterferometric imaging.

FutureGen Project Report

Energy Technology Data Exchange (ETDEWEB)

Cabe, Jim; Elliott, Mike

2010-09-30

This report summarizes the comprehensive siting, permitting, engineering, design, and costing activities completed by the FutureGen Industrial Alliance, the Department of Energy, and associated supporting subcontractors to develop a first of a kind near zero emissions integrated gasification combined cycle power plant and carbon capture and storage project (IGCC-CCS). With the goal to design, build, and reliably operate the first IGCC-CCS facility, FutureGen would have been the lowest emitting pulverized coal power plant in the world, while providing a timely and relevant basis for coal combustion power plants deploying carbon capture in the future. The content of this report summarizes key findings and results of applicable project evaluations; modeling, design, and engineering assessments; cost estimate reports; and schedule and risk mitigation from initiation of the FutureGen project through final flow sheet analyses including capital and operating reports completed under DOE award DE-FE0000587. This project report necessarily builds upon previously completed siting, design, and development work executed under DOE award DE-FC26- 06NT4207 which included the siting process; environmental permitting, compliance, and mitigation under the National Environmental Policy Act; and development of conceptual and design basis documentation for the FutureGen plant. For completeness, the report includes as attachments the siting and design basis documents, as well as the source documentation for the following: • Site evaluation and selection process and environmental characterization • Underground Injection Control (UIC) Permit Application including well design and subsurface modeling • FutureGen IGCC-CCS Design Basis Document • Process evaluations and technology selection via Illinois Clean Coal Review Board Technical Report • Process flow diagrams and heat/material balance for slurry-fed gasifier configuration • Process flow diagrams and heat/material balance

Orofacial clinical features in Arnold Chiari type I malformation: A case series.

Science.gov (United States)

de Arruda, José-Alcides; Figueiredo, Eugênia; Monteiro, João-Luiz; Barbosa, Livia-Mirelle; Rodrigues, Cleomar; Vasconcelos, Belmiro

2018-04-01

Arnold Chiari malformation (ACM) is characterized by an anatomical defect at the base of the skull where the cerebellum and the spinal cord herniate through the foramen magnum into the cervical spinal canal. Among the subtypes of the condition, ACM type I (ACM-I) is particularly outstanding because of the severity of symptoms. This study aimed to analyze the orofacial clinical manifestations of patients with ACM-I, and discuss their demographic distribution and clinical features in light of the literature. A case series with patients with ACM-I treated between 2012 and 2015 was described. The sample consisted of patients who were referred by the Department of Neurosurgery to the Oral and Maxillofacial Surgery Service of Hospital da Restauração in Brazil for the assessment of facial symptomatology. A questionnaire was applied to evaluate the presence of painful orofacial findings. Data are reported using descriptive statistical methods. Mean patient age was 39.3 years and the sample consisted mostly of male patients. A high prevalence of headache (50%) and pain in the neck (66.7%) and masticatory muscles (50%) was found. Only one patient reported difficulty in performing mandibular movements and two reported jaw clicking sounds. Mean mouth opening was 40.83 mm. ACM-I patients may exhibit orofacial symptoms which may mimic temporomandibular joint disorders. This study brings interesting information that could help clinicians and oral and maxillofacial surgeons to understand this uncommon condition and also help with the diagnosis of patients with similar physical characteristics by referring them to a neurosurgeon. Key words: Arnold-Chiari malformation, facial pain, diagnosis, orofacial.

Oxygen-Dependent Transcriptional Regulator Hap1p Limits Glucose Uptake by Repressing the Expression of the Major Glucose Transporter Gene RAG1 in Kluyveromyces lactis▿

Science.gov (United States)

Bao, Wei-Guo; Guiard, Bernard; Fang, Zi-An; Donnini, Claudia; Gervais, Michel; Passos, Flavia M. Lopes; Ferrero, Iliana; Fukuhara, Hiroshi; Bolotin-Fukuhara, Monique

2008-01-01

The HAP1 (CYP1) gene product of Saccharomyces cerevisiae is known to regulate the transcription of many genes in response to oxygen availability. This response varies according to yeast species, probably reflecting the specific nature of their oxidative metabolism. It is suspected that a difference in the interaction of Hap1p with its target genes may explain some of the species-related variation in oxygen responses. As opposed to the fermentative S. cerevisiae, Kluyveromyces lactis is an aerobic yeast species which shows different oxygen responses. We examined the role of the HAP1-equivalent gene (KlHAP1) in K. lactis. KlHap1p showed a number of sequence features and some gene targets (such as KlCYC1) in common with its S. cerevisiae counterpart, and KlHAP1 was capable of complementing the hap1 mutation. However, the KlHAP1 disruptant showed temperature-sensitive growth on glucose, especially at low glucose concentrations. At normal temperature, 28°C, the mutant grew well, the colony size being even greater than that of the wild type. The most striking observation was that KlHap1p repressed the expression of the major glucose transporter gene RAG1 and reduced the glucose uptake rate. This suggested an involvement of KlHap1p in the regulation of glycolytic flux through the glucose transport system. The ΔKlhap1 mutant showed an increased ability to produce ethanol during aerobic growth, indicating a possible transformation of its physiological property to Crabtree positivity or partial Crabtree positivity. Dual roles of KlHap1p in activating respiration and repressing fermentation may be seen as a basis of the Crabtree-negative physiology of K. lactis. PMID:18806211

HapHop-Physio: a computer game to support cognitive therapies in children.

Science.gov (United States)

Rico-Olarte, Carolina; López, Diego M; Narváez, Santiago; Farinango, Charic D; Pharow, Peter S

2017-01-01

Care and support of children with physical or mental disabilities are accompanied with serious concerns for parents, families, healthcare institutions, schools, and their communities. Recent studies and technological innovations have demonstrated the feasibility of providing therapy and rehabilitation services to children supported by computer games. The aim of this paper is to present HapHop-Physio, an innovative computer game that combines exercise with fun and learning, developed to support cognitive therapies in children. Conventional software engineering methods such as the Scrum methodology, a functionality test and a related usability test, were part of the comprehensive methodology adapted to develop HapHop-Physio. The game supports visual and auditory attention therapies, as well as visual and auditory memory activities. The game was developed by a multidisciplinary team, which was based on the Hopscotch ® platform provided by Fraunhofer Institute for Digital Media Technology IDMT Institute in Germany, and designed in collaboration with a rehabilitation clinic in Colombia. HapHop-Physio was tested and evaluated to probe its functionality and user satisfaction. The results show the development of an easy-to-use and funny game by a multidisciplinary team using state-of-the-art videogame technologies and software methodologies. Children testing the game concluded that they would like to play again while undergoing rehabilitation therapies.

Time-dependent cytokine expression in bone of experimental animals after hydroxyapatite (Hap) implantation

International Nuclear Information System (INIS)

Pilmane, M; Salms, G; Salma, I; Skagers, A; Locs, J; Loca, D; Berzina-Cimdina, L

2011-01-01

Proinflammatory cytokines mediate bone loss around the implants in patients with peri-implant disease. However, there is no complete data about the expression of cytokines into the bone around the implants. The aim of this work was to investigate the distribution and appearance of inflammatory cytokines and anti-inflammatory proteins in the bone of jaw of experimental rabbits in different time periods after HAp implantation. Material was obtained from 8 rabbits in lower jaw 6 and 8 months after HAp implants were placed. Tissues were processed for immunohistochemical detection of tumor necrosis factor alfa (TNFα), Interleukin 1, 6, 8, 10 (IL-1, IL-6, IL-8, IL-10) and defensin 2. Results demonstrated practically unchanged expression of IL-6 and IL-10 between both - experimental and control side 6 months after implantation, while IL-1 and IL-8 notably increased in control side. IL-1 and IL-10 expression did not change in either the experimental side nor the controle side after 8 months HAP implantation, but IL-6 and IL-8 demonstrated a decrease in the control sites. Only IL-8 was elevated with time in experimental sites, while IL-10 showed individual variations in 2 cases.

Time-dependent cytokine expression in bone of experimental animals after hydroxyapatite (Hap) implantation

Energy Technology Data Exchange (ETDEWEB)

Pilmane, M [Riga Stradins University, Institute of Anatomy and Anthropology, Dzirciema 16, LV-1007, Riga (Latvia); Salms, G; Salma, I; Skagers, A [Riga Stradins University, Department of Oral and Maxillofacial Surgery, Dzirciema 20. LV-1007, Riga (Latvia); Locs, J; Loca, D; Berzina-Cimdina, L, E-mail: pilmane@latnet.lv [Riga Technical University, Riga Biomaterials innovation and development centre, Pulka 3/3, LV-1007, Riga (Latvia)

2011-06-23

Proinflammatory cytokines mediate bone loss around the implants in patients with peri-implant disease. However, there is no complete data about the expression of cytokines into the bone around the implants. The aim of this work was to investigate the distribution and appearance of inflammatory cytokines and anti-inflammatory proteins in the bone of jaw of experimental rabbits in different time periods after HAp implantation. Material was obtained from 8 rabbits in lower jaw 6 and 8 months after HAp implants were placed. Tissues were processed for immunohistochemical detection of tumor necrosis factor alfa (TNF{alpha}), Interleukin 1, 6, 8, 10 (IL-1, IL-6, IL-8, IL-10) and defensin 2. Results demonstrated practically unchanged expression of IL-6 and IL-10 between both - experimental and control side 6 months after implantation, while IL-1 and IL-8 notably increased in control side. IL-1 and IL-10 expression did not change in either the experimental side nor the controle side after 8 months HAP implantation, but IL-6 and IL-8 demonstrated a decrease in the control sites. Only IL-8 was elevated with time in experimental sites, while IL-10 showed individual variations in 2 cases.

Low HAP/VOC Compliant Resins for Military Applications

Science.gov (United States)

2011-09-01

commumty that was dooradng the perchlorote. Soy Oil 1Walls’ Win Against Perchlorate Texas Military Facility Gets EPA, State OK for Reuse T he...accomplishment is rhe soy - bean, or to be more precise its derivative, soy oil , which cleaned up the chemicals and saved millions of dollars. 5 Army’s Soy ...Fourier Transform Infrared Spectroscopy GM: Glycidyl methacrylate GPC: Gel Permeation Chromatography HAP: Hazardous Air Pollutants HMMWV: High

Relative Contribution of P5 and Hap Surface Proteins to Nontypable Haemophilus influenzae Interplay with the Host Upper and Lower Airways

Science.gov (United States)

Viadas, Cristina; Ruiz de los Mozos, Igor; Valle, Jaione; Bengoechea, José Antonio; Garmendia, Junkal

2015-01-01

Nontypable Haemophilus influenzae (NTHi) is a major cause of opportunistic respiratory tract disease, and initiates infection by colonizing the nasopharynx. Bacterial surface proteins play determining roles in the NTHi-airways interplay, but their specific and relative contribution to colonization and infection of the respiratory tract has not been addressed comprehensively. In this study, we focused on the ompP5 and hap genes, present in all H. influenzae genome sequenced isolates, and encoding the P5 and Hap surface proteins, respectively. We employed isogenic single and double mutants of the ompP5 and hap genes generated in the pathogenic strain NTHi375 to evaluate P5 and Hap contribution to biofilm growth under continuous flow, to NTHi adhesion, and invasion/phagocytosis on nasal, pharyngeal, bronchial, alveolar cultured epithelial cells and alveolar macrophages, and to NTHi murine pulmonary infection. We show that P5 is not required for bacterial biofilm growth, but it is involved in NTHi interplay with respiratory cells and in mouse lung infection. Mechanistically, P5NTHi375 is not a ligand for CEACAM1 or α5 integrin receptors. Hap involvement in NTHi375-host interaction was shown to be limited, despite promoting bacterial cell adhesion when expressed in H. influenzae RdKW20. We also show that Hap does not contribute to bacterial biofilm growth, and that its absence partially restores the deficiency in lung infection observed for the ΔompP5 mutant. Altogether, this work frames the relative importance of the P5 and Hap surface proteins in NTHi virulence. PMID:25894755

HapTip: Displaying Haptic Shear Forces at the Fingertips for Multi-Finger Interaction in Virtual Environments

Directory of Open Access Journals (Sweden)

Adrien eGirard

2016-04-01

Full Text Available The fingertips are one of the most important and sensitive parts of our body.They are the first stimulated areas of the hand when we interact with our environment.Providing haptic feedback to the fingertips in virtual reality could thus drastically improve perception and interaction with virtual environments.In this paper, we present a modular approach called HapTip to display such haptic sensations at the level of the fingertips.This approach relies on a wearable and compact haptic device able to simulate 2 Degree of Freedom (DoF shear forces on the fingertip with a displacement range of +/- 2 mm. Several modules can be added and used jointly in order to address multi-finger and/or bimanual scenarios in virtual environments.For that purpose, we introduce several haptic rendering techniques to cover different cases of 3D interaction such as touching a rough virtual surface, or feeling the inertia or weight of a virtual object.In order to illustrate the possibilities offered by HapTip, we provide four use cases focused on touching or grasping virtual objects.To validate the efficiency of our approach, we also conducted experiments to assess the tactile perception obtained with HapTip.Our results show that participants can successfully discriminate the directions of the 2 DoF stimulation of our haptic device.We found also that participants could well perceive different weights of virtual objects simulated using two HapTip devices. We believe that HapTip could be used in numerous applications in virtual reality for which 3D manipulation and tactile sensations are often crucial, such as in virtual prototyping or virtual training.

Pühapäev kunsti ja muusikaga / Mari Hiiemäe

Index Scriptorium Estoniae

Hiiemäe, Mari

2008-01-01

Jazzkaare 20. aprillil korraldatavast kunsti ja muusika pühapäevast Niguliste muuseumis (esineb East-West Quartet), Tallinna Kunstihoones (Estonian Guitar Octet), Rotermanni soolalaos (Raivo Tafenau ja Meelis Vindi duo) ja Kumu auditooriumis (laulja Kelli Uustani plaadiesitlus)

40 CFR Table 31 to Subpart Uuu of... - Continuous Monitoring Systems for HAP Emissions From Sulfur Recovery Units

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 12 2010-07-01 2010-07-01 true Continuous Monitoring Systems for HAP Emissions From Sulfur Recovery Units 31 Table 31 to Subpart UUU of Part 63 Protection of Environment..., Subpt. UUU, Table 31 Table 31 to Subpart UUU of Part 63—Continuous Monitoring Systems for HAP Emissions...

40 CFR Table 34 to Subpart Uuu of... - Continuous Compliance With HAP Emission Limits for Sulfur Recovery Units

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 12 2010-07-01 2010-07-01 true Continuous Compliance With HAP Emission Limits for Sulfur Recovery Units 34 Table 34 to Subpart UUU of Part 63 Protection of Environment..., Subpt. UUU, Table 34 Table 34 to Subpart UUU of Part 63—Continuous Compliance With HAP Emission Limits...

40 CFR 63.5753 - How do I calculate the combined organic HAP content of aluminum wipedown solvents and aluminum...

Science.gov (United States)

2010-07-01

... HAP content of aluminum wipedown solvents and aluminum recreational boat surface coatings? 63.5753... Standards for Hazardous Air Pollutants for Boat Manufacturing Standards for Aluminum Recreational Boat Surface Coating Operations § 63.5753 How do I calculate the combined organic HAP content of aluminum...

Arnold Sommerfeld science, life and turbulent times : 1868-1951

CERN Document Server

Eckert, Michael

2013-01-01

Arnold Sommerfeld (1868-1951) belongs with Max Planck (1858-1947), Albert Einstein (1879-1955) and Niels Bohr (1885-1962) among the founders of modern theoretical physics, a science that developed into a budding discipline during his lifetime. Sommerfeld witnessed many of the most dramatic scientific, cultural and political events of this era. His correspondence with his family offers a vivid testament to the challenges and joys of a life in science. This biography attempts to reconstruct Sommerfeld’s life and work not only from the perspective of his achievements in theoretical physics but also with the goal of portraying the career of a scientist within the social and political environment in which it evolved. It is based to a large extent on Sommerfeld’s voluminous correspondence, which sheds light both on his private and scientific life. Furthermore, it provides an authentic view on the circumstances that shaped Sommerfeld’s career in different places – Königsberg, Göttingen, Clausthal, Aachen, ...

40 CFR Table 33 to Subpart Uuu of... - Initial Compliance With HAP Emission Limits for Sulfur Recovery Units

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 12 2010-07-01 2010-07-01 true Initial Compliance With HAP Emission Limits for Sulfur Recovery Units 33 Table 33 to Subpart UUU of Part 63 Protection of Environment..., Subpt. UUU, Table 33 Table 33 to Subpart UUU of Part 63—Initial Compliance With HAP Emission Limits for...

40 CFR Table 9 to Subpart Uuu of... - Operating Limits for Organic HAP Emissions From Catalytic Cracking Units

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 12 2010-07-01 2010-07-01 true Operating Limits for Organic HAP Emissions From Catalytic Cracking Units 9 Table 9 to Subpart UUU of Part 63 Protection of Environment..., Subpt. UUU, Table 9 Table 9 to Subpart UUU of Part 63—Operating Limits for Organic HAP Emissions From...

40 CFR Table 16 to Subpart Uuu of... - Operating Limits for Organic HAP Emissions From Catalytic Reforming Units

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 12 2010-07-01 2010-07-01 true Operating Limits for Organic HAP Emissions From Catalytic Reforming Units 16 Table 16 to Subpart UUU of Part 63 Protection of Environment..., Subpt. UUU, Table 16 Table 16 to Subpart UUU of Part 63—Operating Limits for Organic HAP Emissions From...

Final Environmental Assessment: Construction of SWMU 74 Groundwater Extraction and Convenience System Arnold Air Force Base, Tennessee

Science.gov (United States)

2004-08-01

trillium) Vaccinium macrocarpon ( Cranberry ) Zigadenus leimanthoides (Death camas) Conservation Target Species Occurring in Wetland Depressions ...890 feet above sea level in the valleys. In the areas north and northeast of Arnold AFB, there are many swamps and internally drained depressions ...also is found in the area. Dickson soils occur primarily on undulating or nearly level to depressed areas. The upper layers of these soils are

Tähtis kokkuvõtteid teha : EPA - 35 / Minna Klementi, Arnold Rüütel, Nikolai Kozlov ... [jt.] ; [intervjueerinud] Tiina Siimets

Index Scriptorium Estoniae

1986-01-01

Küsimustele vastavad EPA endised rektorid Minna Klementi ja Arnold Rüütel, rektor Nikolai Kozlov, ATK esimees Heino Veldi, ATK esimehe esimene asetäitja, ENSV minister Vello Lind, ATK esimehe asetäitja Jüri Kulbin, ATK esimehe asetäitja, EPA põllumajandusloomade aretuse kateedri professori kt. Olev Saveli

"Kui riigikogu presidenti valida ei suuda, siis ma ei soovitaks Arnold Rüütlil uuesti Kadriorgu kandideerida / Arno Almann ; interv. Urmo Soonvald

Index Scriptorium Estoniae

Almann, Arno, 1950-

2006-01-01

Nõukogude Eestis Arnold Rüütlit nõustanud Arno Almann on üks endistest kommunistliku partei liikmetest, kes tänavu presidendilt ordeni saab. Lähiajaloo ja endiste liidrite tegevusele hinnangu andmine. Lisa: kes on Arno Almann?

"Kui riigikogu presidenti valida ei suuda, siis ma ei soovitaks Arnold Rüütlil uuesti Kadriorgu kandideerida." / Arno Almann ; interv. Urmo Soonvald

Index Scriptorium Estoniae

Almann, Arno 1950-

2006-01-01

Nõukogude Eestis Arnold Rüütlit nõustanud Arno Almann on üks endistest kommunistliku partei liikmetest, kes tänavu presidendilt ordeni saab. Lähiajaloo ja endiste liidrite tegevusele hinnangu andmine. Lisa: Kes on Arno Almann?

Biocorrosion and osteoconductivity of PCL/nHAp composite porous film-based coating of magnesium alloy

Science.gov (United States)

Abdal-hay, Abdalla; Amna, Touseef; Lim, Jae Kyoo

2013-04-01

The present study was aimed at designing a novel porous hydroxyapatite/poly(ɛ-caprolactone) (nHAp/PCL) hybrid nanocomposite matrix on a magnesium substrate with high and low porosity. The coated samples were prepared using a dip-coating technique in order to enhance the bioactivity and biocompatibility of the implant and to control the degradation rate of magnesium alloys. The mechanical and biocompatible properties of the coated and uncoated samples were investigated and an in vitro test for corrosion was conducted by electrochemical polarization and measurement of weight loss. The corrosion test results demonstrated that both the pristine PCL and nHAp/PCL composites showed good corrosion resistance in SBF. However, during the extended incubation time, the composite coatings exhibited more uniform and superior resistance to corrosion attack than pristine PCL, and were able to survive severe localized corrosion in physiological solution. Furthermore, the bioactivity of the composite film was determined by the rapid formation of uniform CaP nanoparticles on the sample surfaces during immersion in SBF. The mechanical integrity of the composite coatings displayed better performance (˜34% higher) than the uncoated samples. Finally, our results suggest that the nHAp incorporated with novel PCL composite membranes on magnesium substrates may serve as an excellent 3-D platform for cell attachment, proliferation, migration, and growth in bone tissue. This novel as-synthesized nHAp/PCL membrane on magnesium implants could be used as a potential material for orthopedic applications in the future.

Recommendations and Requirements for GenCade Simluations

Science.gov (United States)

2014-08-01

will report whether or not GenCade is enabled. If GenCade is disabled , the user will need a new license that includes GenCade...any depth but usually are not deeper than the seaward edge of the surf - zone. In the same way that some shorelines are less desirable for use in...Conference, 1919–1937. ASCE. Wang, P., N. C. Kraus, and R. A. Davis. 1998. Total rate of longshore sediment transport in the surf zone: Field

40 CFR Table 27 to Subpart Uuu of... - Continuous Compliance With Inorganic HAP Emission Limits for Catalytic Reforming Units

Science.gov (United States)

2010-07-01

... HAP Emission Limits for Catalytic Reforming Units 27 Table 27 to Subpart UUU of Part 63 Protection of... Pollutants for Petroleum Refineries: Catalytic Cracking Units, Catalytic Reforming Units, and Sulfur Recovery... Inorganic HAP Emission Limits for Catalytic Reforming Units As stated in § 63.1567(c)(1), you shall meet...

Performance Assessment of Hazardous Air Pollutant (HAP)Free Chemical Paint Strippers on Military Coatings for Validation to Federal Specification TT-R-2918A

Science.gov (United States)

2016-03-01

ARL-TN-0742 ● MAR 2016 US Army Research Laboratory Performance Assessment of Hazardous Air Pollutant (HAP)–Free Chemical Paint...the originator. ARL-TN-0742 ● MAR 2016 US Army Research Laboratory Performance Assessment of Hazardous Air Pollutant (HAP...COVERED (From - To) 1–30 April 2014 4. TITLE AND SUBTITLE Performance Assessment of Hazardous Air Pollutant (HAP)–Free Chemical Paint Strippers

On the High Altitude Platform (HAP W-CDMA System Capacity

Directory of Open Access Journals (Sweden)

L. de Haro-Ariet

2004-06-01

Full Text Available The performance of a downlink power control model, based on a n-thpower distance law, is evaluated for high altitude platform station(HAPS W-CDMA systems. The downlink capacity using this model iscompared with the uplink capacity. It is shown that the uplink capacityis higher than the downlink capacity.

Unleashing Gen Y: Marketing Mars to Millennials

Science.gov (United States)

Leahy, Bart D.; Hidalgo, Loretta; Kloberdanz, Cassie

2007-01-01

Space advocates need to engage Generation Y (born 1977-1999).This outreach is necessary to recruit the next generation of scientists and engineers to explore Mars. Space advocates in the non-profit, private, and government sectors need to use a combination of technical communication, marketing, and politics, to develop messages that resonate with Gen Y. Until now, space messages have been generated by and for college-educated white males; Gen Y is much more diverse, including as much as one third minorities. Young women, too, need to be reached. My research has shown that messages emphasizing technology, fun, humor, and opportunity are the best means of reaching the Gen Y audience of 60 million (US population is 300 million). The important things space advocates must avoid are talking down to this generation, making false promises, or expecting them to "wait their turn" before they can participate. This is the MTV generation! We need to find ways of engaging Gen Y now to build a future where human beings can live and work on the planet Mars. In addition to the messages themselves, advocates need to keep up with Gen Y' s social networking and use of iPods, cell phones, and the Internet. NASA and space advocacy groups can use these tools for "viral marketing," where young people share targeted space-related information via cell phones or the Internet because they like it. Overall, Gen Y is a socially dynamic and media-savvy group; advocates' space messages need to be sincere, creative, and placed in locations where Gen Y lives. Mars messages must be memorable!

Unilateral phrenic nerve stimulation for neurogenic hypoventilation in Arnold Chiari malformation

Directory of Open Access Journals (Sweden)

Nitin Garg

2013-01-01

Full Text Available Long- term ventilator dependence in patients with neurogenic hypoventilation is associated with significant morbidity and restricts mobility. Diaphragmatic pacing by phrenic nerve stimulation (PNS is a viable alternative. This is a case report of patient with Arnold-Chiari malformation with extensive syrinx who had neurogenic hypoventilation during sleep even after foramen magnum decompression and resolution of the syrinx. Unilateral PNS was done using spinal cord stimulator. With intermittent stimulation for 8 h while asleep, patient could be weaned off the ventilator completely. At 2 years follow- up, patient is ambulant and has returned to his routine activities. PNS is a good treatment tool in patients with neurogenic hypoventilation. Spinal cord stimulator can be used with optimal results. This is first such reported case of using spinal cord stimulator for PNS from India.

40 CFR Table 19 to Subpart Uuu of... - Initial Compliance With Organic HAP Emission Limits for Catalytic Reforming Units

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 12 2010-07-01 2010-07-01 true Initial Compliance With Organic HAP Emission Limits for Catalytic Reforming Units 19 Table 19 to Subpart UUU of Part 63 Protection of... HAP Emission Limits for Catalytic Reforming Units As stated in § 63.1566(b)(7), you shall meet each...

40 CFR Table 12 to Subpart Uuu of... - Initial Compliance With Organic HAP Emission Limits for Catalytic Cracking Units

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 12 2010-07-01 2010-07-01 true Initial Compliance With Organic HAP Emission Limits for Catalytic Cracking Units 12 Table 12 to Subpart UUU of Part 63 Protection of... HAP Emission Limits for Catalytic Cracking Units As stated in § 63.1565(b)(4), you shall meet each...

40 CFR Table 17 to Subpart Uuu of... - Continuous Monitoring Systems for Organic HAP Emissions From Catalytic Reforming Units

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 12 2010-07-01 2010-07-01 true Continuous Monitoring Systems for Organic HAP Emissions From Catalytic Reforming Units 17 Table 17 to Subpart UUU of Part 63 Protection of... Organic HAP Emissions From Catalytic Reforming Units As stated in § 63.1566(b)(1), you shall meet each...

40 CFR Table 13 to Subpart Uuu of... - Continuous Compliance With Organic HAP Emission Limits for Catalytic Cracking Units

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 12 2010-07-01 2010-07-01 true Continuous Compliance With Organic HAP Emission Limits for Catalytic Cracking Units 13 Table 13 to Subpart UUU of Part 63 Protection of... HAP Emission Limits for Catalytic Cracking Units As stated in § 63.1565(c)(1), you shall meet each...

40 CFR Table 20 to Subpart Uuu of... - Continuous Compliance With Organic HAP Emission Limits for Catalytic Reforming Units

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 12 2010-07-01 2010-07-01 true Continuous Compliance With Organic HAP Emission Limits for Catalytic Reforming Units 20 Table 20 to Subpart UUU of Part 63 Protection of... HAP Emission Limits for Catalytic Reforming Units As stated in § 63.1566(c)(1), you shall meet each...

40 CFR Table 10 to Subpart Uuu of... - Continuous Monitoring Systems for Organic HAP Emissions From Catalytic Cracking Units

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 12 2010-07-01 2010-07-01 true Continuous Monitoring Systems for Organic HAP Emissions From Catalytic Cracking Units 10 Table 10 to Subpart UUU of Part 63 Protection of... Organic HAP Emissions From Catalytic Cracking Units As stated in § 63.1565(b)(1), you shall meet each...

Present and future emissions of HAPs from crematories in China

Science.gov (United States)

Xue, Yifeng; Tian, Hezhong; Yan, Jing; Xiong, Chengcheng; Pan, Tao; Nie, Lei; Wu, Xiaoqing; Li, Jing; Wang, Wei; Gao, Jiajia; Zhu, Chuanyong; Wang, Kun

2016-01-01

China is the most populous country in the world. The amount of death population has reached 9.65 million and 49.5% of human corpses are cremated by about 1700 crematories spread throughout the country in 2012, leading to considerable discharge of various hazardous air pollutants (HAPs) into the atmosphere and great concerns on regional air quality and health risks for surrounding residents. By using the practicable or best available emission factors, for the first time, a multiple-year emission inventory of typical hazardous air pollutants discharged from crematories in the Chinese mainland, has been established for the historical period of 1990-2012, and the future trends of HAPs emissions until 2030 are forecasted based on three scenarios analysis. Our results show that the total emissions have gradually increased to 906 t of NOX, 443 t of SO2, 2713 t of CO, 477.7 t of PM, 377 t of HCl, 36 t of H2S, 25 t of NH3, 62 t of NMVOCs, 592 kg of Hg, 48 kg of Pb, 14 kg of Cd, 53 kg of As, 40 kg of Cr, 37 kg of Cu, 51 kg of Ni, and 96 g of PCDD/Fs as TEQ (toxic equivalent quantity) by the year 2012. Under the business-as-usual (BAU) scenario, various HAPs emitted from cremators would continuously increase with an average growth rate of 3% till to 2030; whereas the emissions will peak at around 2015 and then decline gradually with varied speed under the two improved control scenarios. To mitigate the associated air pollution and health risks caused by crematories, it is of great necessary for implementing more strict emission standards, applying combustion optimization and requiring installation of best available flue gas purification system, as well as powerful supervision for sound operation of crematories.

40 CFR 63.2854 - How do I determine the weighted average volume fraction of HAP in the actual solvent loss?

Science.gov (United States)

2010-07-01

... volume fraction of HAP in the actual solvent loss? 63.2854 Section 63.2854 Protection of Environment... AIR POLLUTANTS FOR SOURCE CATEGORIES National Emission Standards for Hazardous Air Pollutants: Solvent... average volume fraction of HAP in the actual solvent loss? (a) This section describes the information and...

40 CFR Table 6 to Subpart Uuu of... - Continuous Compliance With Metal HAP Emission Limits for Catalytic Cracking Units

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 12 2010-07-01 2010-07-01 true Continuous Compliance With Metal HAP Emission Limits for Catalytic Cracking Units 6 Table 6 to Subpart UUU of Part 63 Protection of Environment..., Subpt. UUU, Table 6 Table 6 to Subpart UUU of Part 63—Continuous Compliance With Metal HAP Emission...

40 CFR Table 5 to Subpart Uuu of... - Initial Compliance With Metal HAP Emission Limits for Catalytic Cracking Units

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 12 2010-07-01 2010-07-01 true Initial Compliance With Metal HAP Emission Limits for Catalytic Cracking Units 5 Table 5 to Subpart UUU of Part 63 Protection of Environment..., Subpt. UUU, Table 5 Table 5 to Subpart UUU of Part 63—Initial Compliance With Metal HAP Emission Limits...

Modelo poblacional con algoritmos genéticos

OpenAIRE

Veliz Quintero, Eduardo; Rodriguez Ojeda, Luis

2009-01-01

Para el desarrollo de este trabajo, “MODELO POBLACIONAL CON ALGORITMOS GENÉTICOS”, he investigado la rama de la inteligencia artificial, como son los algoritmos genéticos. Primero presento en forma general los aspectos que envuelven los algoritmos genéticos, parto de la necesidad de optimizar, así como su historia y posibles aplicaciones y luego he cubierto detalladamente todo lo que pude investigar sobre la teoría de los algoritmos genéticos, sus fundamentos matemáticos, tipos de algoritmos ...

Influence of Growth Parameters on the Formation of Hydroxyapatite (HAp Nanostructures and Their Cell Viability Studies

Directory of Open Access Journals (Sweden)

Murugesan Manoj

2015-02-01

Full Text Available Morphology controlled hydroxyapatite (HAp nanostructures play a vital role in biomedical engineering, tissue regenerative medicine, biosensors, chemotherapeutic applications, environmental remediation, etc. The present work investigates the influence of temperature, pH and time on the growth of HAp nanostructures using a simple, cost effective and surfactant free chemical approach. The obtained HAp nanostructures were systematically investigated by analytical techniques such as XRD, FESEM, EDX, FTIR and Raman spectroscopy. The XRD analysis showed that the hexagonal structure of the hydroxyapatite and average crystallite size was estimated from this analysis. The electron microscopic analysis confirmed the different morphologies obtained by varying the synthesis parameters such as temperature, pH and time. The elemental composition was determined through EDS analysis. FTIR and Raman spectroscopic analysis confirmed the presence of functional groups and the purity and crystallinity of the samples. The biocompatibility and adhesion nature of samples was examined with mouse preosteoblast cells. The obtained results demonstrated good biocompatibility and excellent focal adhesion.

HapMap-based study of the DNA repair gene ERCC2 and lung cancer susceptibility in a Chinese population

DEFF Research Database (Denmark)

Yin, Jiaoyang; Vogel, Ulla Birgitte; Ma, Yegang

2009-01-01

-nucleotide polymorphisms (htSNPs) (rs238403, rs50871, rs3916840, rs238415, rs3916874 and rs1799787) from HapMap database were analyzed, which provide an almost complete coverage of the genetic variations in the ERCC2 gene. Although none of the six htSNPs was individually associated with lung cancer risk, we found that two...... ratio, OR (95% confidence interval, CI) = 2.62 (1.53–4.50), P = 0.0003 for hap4; OR (95% CI) = 3.01 (1.36–6.63), P = 0.004 for hap7]. Furthermore, diplotype analyses also strengthened the significant associations of risk haplotype 4 [OR (95% CI) = 3.56 (2.12–5.87), P

Factors Influencing Retention of Gen Y and Non-Gen Y Teachers Working at International Schools in Asia

Science.gov (United States)

Fong, Hoi Wah Benny

2018-01-01

Quantitative studies on international-school teacher retention are few, especially studies that differentiate between Gen Y and non-Gen Y teachers. This article reports on the findings of a study that examined the relationship of job satisfaction factors to the likelihood of contract renewal by international-school teachers. Results from the study…

The study on electromagnetic compatibility of DC electric motor in HAPS

Energy Technology Data Exchange (ETDEWEB)

Junping, Geng; Ronghong, Jin; Yu, Fan; Bo, Liu; Jiaqiang, Li; Yuebo, Cheng; Zhongyuan, Wang [Shanghai Jiao Tong Univ., Dpt. Electronic Engineering, Shanghai (China)

2005-10-01

The electromagnetic compatibility (EMC) problem of high altitude platform systems (HAPS) is investigated in this paper. A physical model for electromagnetic interferences (EMI) of electromagnetic radiation of spark discharge in DC electric motor is proposed. Based on this model, EMI frequency points has been estimated by approximative equation for the given structure and size of a motor, and EMI frequency points, peak values that received by the ports of antennas and far-field pattern have been calculated. The estimated results are consistent with the calculated ones. These frequency bands and spatial directions with max EMI should be avoided in the valid information when the HAPS system is being designed. Two methods are taken to shield electromagnetic radiation, either to mount a metal plate near the DC electric motor (EMI source), or to mount a perfect conductor board near the antenna array (sensitive element), are valid to shield electromagnetic radiation, but to mount a metal plate near the EMI source is more effective. (authors)

Arnold-Chiari Type II Malformation: A Case Report and Review of Prenatal Sonographic Findings

Directory of Open Access Journals (Sweden)

Maryam Nik Nejadi

2008-01-01

Full Text Available The Arnold-Chiari malformation is a congenital abnormality of CNS, characterized by downwarddisplacement the parts of the cerebellum, fourth ventricle, pons and medulla oblongata into thespinal canal. This malformation is one of causative factor of death in neonates and infants. Athorough understanding of the direct and indirect sonographic findings is necessary for diagnosis ofChiari II malformation in the developing fetus.In this case report, we present a Chiari malformation II detected at 23 weeks of gestation by routinelysonographic screening. The Role of prenatal sonography in recognition of the malformation andprognostic value of these features are discussed.

Arnold Sommerfeld. Atomic physicist and messenger of culture 1868-1951. A biography; Arnold Sommerfeld. Atomphysiker und Kulturbote 1868-1951. Eine Biografie

Energy Technology Data Exchange (ETDEWEB)

Eckert, Michael

2013-09-01

Arnold Sommerfeld is beside Albert Einstein, Niels Bohr, and Max Planck one of the founders of modern atomic and quantum theory. His career began in the 1890th years at the University of Goettingen, the world center of mathematics of that time. Since 1906 he created on the professorship for theoretical physics at the Munich university one of the most important schools of science, the students of which are well-known theorists of the atomic era like as the Nobel-price winners Hans Bethe, Peter Debye, Wolfgang Pauli, and Werner Heisenberg. He also developed far beyond his subject an unprecedented impact. He travelled as ''messenger of culture'' in many countries in order to advertise in the years after the first world war for the reputation of Germany as culture nation. By the nationalsocialism the Munich ''nursery of theoretical physics'' however was prepared an inglorious end, because Sommerfeld counted for a ''main propagandist of Jewish theories''. By the example of this life of a physicist also the eventful history of a whole subject.

Metode Transfer Asam Nukleat sebagai Dasar Terapi Gen

Directory of Open Access Journals (Sweden)

Novi Silvia Hardiany

2017-01-01

Full Text Available Kemajuan ilmu biologi molekuler memberikan manfaat dalam bidang kedokteran untuk mengembangkanterapi gen. Tujuan terapi gen adalah untuk memperbaiki kerusakan gen atau mengganti gen yang rusakdengan gen yang normal. Pemindahan gen dilakukan dengan teknik transfeksi. Transfeksi merupakanproses pemindahan asam nukleat baik menggunakan vektor virus (transduksi atau menggunakan metodenonviral yaitu zat kimia, lipid dan metode fisik. Vektor virus yang digunakan pada transduksi adalahretrovirus, adenovirus, adeno-associated virus (AAV dan herpes simplex virus (HSV. Keberhasilantransfeksi ditentukan oleh berbagai faktor yang dapat dapat dinilai dengan menggunakan reporter sepertigreen fluorescence protein (GFP. Kata Kunci: terapi gen, transfeksi non viral, transduksi, vektor virus   Methods of Nucleic Acid Transfer as Basic Gene Therapy Abstract The advancement of molecular biology provides benefit in the field of medicine to develop genetherapy. The aim of gene therapy is to repair the genetic damage or to replace damaged gene with thenormal gene. Delivery of gene is carried out by transfection technique, a technique to transfer nucleic acidinto eukaryote cells either using viral vectors (known as transduction, and also using non viral methodsuch as chemical substance, lipid and physical method. Some of the viral vectors used in the transductionare retrovirus, adenovirus, Adeno-associated virus (AAV and Herpes Simplex Virus (HSV. The success oftransfection is determined by various factors which can be assessed using several reporters such as GreenFluorescence Protein (GFP. Key words: gene therapy, non viral transfection, transduction, viral vector. Normal 0 false false false IN X-NONE X-NONE

Monitoring by Control Technique - Compliant (Low/No VOC/HAP) Inks and Coatings

Science.gov (United States)

Stationary source emissions monitoring is required to demonstrate that a source is meeting the requirements in Federal or state rules. This page is about Compliant (Low/No VOC/HAP) Inks and Coatings control techniques used to reduce pollutant emissions.

Täna on ülim aeg Eestile öelda, et ta on armastamist väärt / Arnold Rüütel

Index Scriptorium Estoniae

Rüütel, Arnold

2001-01-01

Ilmunud ka Estonija (2001/Oct/10) lk. 2 (lüh.) ; ERL Teataja (2001/Oct) nr.10, lk. 2 ; Raamatus "President". -Tallinn, 2003, lk. 24-29, pealkiri: Eesti iseseisvuse tagatised on riigi ja rahvuslikus eneseväärikuses. President Arnold Rüütli kõne Riigikogus ametisse astumise tseremoonial

An Evaluation of Interference Mitigation Schemes for HAPS Systems

Directory of Open Access Journals (Sweden)

Nam Kim

2008-07-01

Full Text Available The International Telecommunication Union-Radiocommunication sector (ITU-R has conducted frequency sharing studies between fixed services (FSs using a high altitude platform station (HAPS and fixed-satellite services (FSSs. In particular, ITU-R has investigated the power limitations related to HAPS user terminals (HUTs to facilitate frequency sharing with space station receivers. To reduce the level of interference from the HUTs that can harm a geostationary earth orbit (GEO satellite receiver in a space station, previous studies have taken two approaches: frequency sharing using a separated distance (FSSD and frequency sharing using power control (FSPC. In this paper, various performance evaluation results of interference mitigation schemes are presented. The results include performance evaluations using a new interference mitigation approach as well as conventional approaches. An adaptive beamforming scheme (ABS is introduced as a new scheme for efficient frequency sharing, and the interference mitigation effect on the ABS is examined considering pointing mismatch errors. The results confirm that the application of ABS enables frequency sharing between two systems with a smaller power reduction of HUTs in a cocoverage area compared to this reduction when conventional schemes are utilized. In addition, the analysis results provide the proper amount of modification at the transmitting power level of the HUT required for the suitable frequency sharing.

Gamma irradiation of melt processed biomedical PDLLA/HAP nanocomposites

International Nuclear Information System (INIS)

Dadbin, Susan; Kheirkhah, Yahya

2014-01-01

Poly(D-L lactide) PDLLA/hydroxyapatite (HAP) nanocomposites at various compositions were prepared by melt-compounding process and then subjected to gamma irradiation at a dose of 30 kGy. The morphology of the nanocomposites, characterized by transmission electron microscopy (TEM), displayed HAP nanoparticles at various sizes ranging from 10 to 100 nm distributed almost evenly within the polymer matrix. Differential scanning calorimetric (DSC) analysis of the irradiated nanocomposites showed an increase in the degree of crystallinity along with a melting peak split. The double melting peak suggested formation of different crystalline structures in the radiation exposed nanocomposites. Also the cold crystallization peak shifted to lower temperatures and became much sharper upon irradiation, indicating higher crystallization rate. The irradiated nanocomposites showed lower tensile strength and elongation at break, suggesting occurrence of some chain scission reactions in the PLA. - Highlights: • Biomedical polylactic acid/hydroxyapatite nanocomposites prepared by melt-compounding were gamma irradiated. • Transmission electron microscopy showed hydroxyapatite nanoparticles evenly distributed within polylactic acid ranging from 10 to 100 nm. • A halo appeared around hydroxyapatite particles showing interfacial interactions between polylactic acid and the particles. • Double melting peak appeared for polylactic acid in DSC thermograms upon gamma irradiation of the nanocomposites

Exploring multilocus associations of inflammation genes and colorectal cancer risk using hapConstructor

Directory of Open Access Journals (Sweden)

Abo Ryan

2010-12-01

Full Text Available Abstract Background In candidate-gene association studies of single nucleotide polymorphisms (SNPs, multilocus analyses are frequently of high dimensionality when considering haplotypes or haplotype pairs (diplotypes and differing modes of expression. Often, while candidate genes are selected based on their biological involvement in a given pathway, little is known about the functionality of SNPs to guide association studies. Investigators face the challenge of exploring multiple SNP models to elucidate which variants, independently or in combination, might be associated with a disease of interest. A data mining module, hapConstructor (freely-available in Genie software performs systematic construction and association testing of multilocus genotype data in a Monte Carlo framework. Our objective was to assess its utility to guide statistical analyses of haplotypes within a candidate region (or combined genotypes across candidate genes beyond that offered by a standard logistic regression approach. Methods We applied the hapConstructor method to a multilocus investigation of candidate genes involved in pro-inflammatory cytokine IL6 production, IKBKB, IL6, and NFKB1 (16 SNPs total hypothesized to operate together to alter colorectal cancer risk. Data come from two U.S. multicenter studies, one of colon cancer (1,556 cases and 1,956 matched controls and one of rectal cancer (754 cases and 959 matched controls. Results HapConstrcutor enabled us to identify important associations that were further analyzed in logistic regression models to simultaneously adjust for confounders. The most significant finding (nominal P = 0.0004; false discovery rate q = 0.037 was a combined genotype association across IKBKB SNP rs5029748 (1 or 2 variant alleles, IL6 rs1800797 (1 or 2 variant alleles, and NFKB1 rs4648110 (2 variant alleles which conferred an ~80% decreased risk of colon cancer. Conclusions Strengths of hapConstructor were: systematic identification of

40 CFR Table 18 to Subpart Uuu of... - Requirements for Performance Tests for Organic HAP Emissions From Catalytic Reforming Units

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 12 2010-07-01 2010-07-01 true Requirements for Performance Tests for Organic HAP Emissions From Catalytic Reforming Units 18 Table 18 to Subpart UUU of Part 63 Protection of... for Organic HAP Emissions From Catalytic Reforming Units As stated in § 63.1566(b)(2) and (3), you...

Characterization of Romboutsia ilealis gen. nov., sp. nov., isolated from the gastro-intestinal tract of a rat, and proposal for the reclassification of five closely related members of the genus Clostridium into the genera Romboutsia gen. nov., Intestinibacter gen. nov., Terrisporobacter gen. nov. and Asaccharospora gen. nov.

Science.gov (United States)

Gerritsen, Jacoline; Fuentes, Susana; Grievink, Wieke; van Niftrik, Laura; Tindall, Brian J; Timmerman, Harro M; Rijkers, Ger T; Smidt, Hauke

2014-05-01

A Gram-positive staining, rod-shaped, non-motile, spore-forming obligately anaerobic bacterium, designated CRIBT, was isolated from the gastro-intestinal tract of a rat and characterized. The major cellular fatty acids of strain CRIBT were saturated and unsaturated straight-chain C12-C19 fatty acids, with C16:0 being the predominant fatty acid. The polar lipid profile comprised six glycolipids, four phospholipids and one lipid that did not stain with any of the specific spray reagents used. The only quinone was MK-6. The predominating cell-wall sugars were glucose and galactose. The peptidoglycan type of strain CRIBT was A1σ lanthionine-direct. The genomic DNA G+C content of strain CRIBT was 28.1 mol%. On the basis of 16S rRNA gene sequence similarity, strain CRIBT was most closely related to a number of species of the genus Clostridium, including Clostridium lituseburense (97.2%), Clostridium glycolicum (96.2%), Clostridium mayombei (96.2%), Clostridium bartlettii (96.0%) and Clostridium irregulare (95.5%). All these species show very low 16S rRNA gene sequence similarity (genus Clostridium. DNA-DNA hybridization with closely related reference strains indicated reassociation values below 32%. On the basis of phenotypic and genetic studies, a novel genus, Romboutsia gen. nov., is proposed. The novel isolate CRIBT (=DSM 25109T=NIZO 4048T) is proposed as the type strain of the type species, Romboutsia ilealis gen. nov., sp. nov., of the proposed novel genus. It is proposed that C. lituseburense is transferred to this genus as Romboutsia lituseburensis comb. nov. Furthermore, the reclassification into novel genera is proposed for C. bartlettii, as Intestinibacter bartlettii gen. nov., comb. nov. (type species of the genus), C. glycolicum, as Terrisporobacter glycolicus gen. nov., comb. nov. (type species of the genus), C. mayombei, as Terrisporobacter mayombei gen. nov., comb. nov., and C. irregulare, as Asaccharospora irregularis gen. nov., comb. nov. (type species

J3Gen: A PRNG for Low-Cost Passive RFID

Directory of Open Access Journals (Sweden)

Jordi Herrera-Joancomartí

2013-03-01

Full Text Available Pseudorandom number generation (PRNG is the main security tool in low-cost passive radio-frequency identification (RFID technologies, such as EPC Gen2. We present a lightweight PRNG design for low-cost passive RFID tags, named J3Gen. J3Gen is based on a linear feedback shift register (LFSR configured with multiple feedback polynomials. The polynomials are alternated during the generation of sequences via a physical source of randomness. J3Gen successfully handles the inherent linearity of LFSR based PRNGs and satisfies the statistical requirements imposed by the EPC Gen2 standard. A hardware implementation of J3Gen is presented and evaluated with regard to different design parameters, defining the key-equivalence security and nonlinearity of the design. The results of a SPICE simulation confirm the power-consumption suitability of the proposal.

O impacto da genética na asma infantil

OpenAIRE

Pinto,Leonardo A.; Stein,Renato T.; Kabesch,Michael

2008-01-01

OBJETIVO: Apresentar os resultados dos estudos mais importantes e recentes sobre a genética da asma. Estes dados devem auxiliar os clínicos gerais a compreender o impacto da genética sobre este distúrbio complexo e como os genes e polimorfismos influenciam a asma e a atopia. FONTES DOS DADOS: Os dados foram coletados do banco de dados MEDLINE. Os estudos de associação genética foram selecionados do Genetic Association Database, um repositório de estudos de associação genética de doenças e dis...

Discusión: Explicaciones genéticas y psicológicas de la esquizofrenia.Genética de la esperanza

Directory of Open Access Journals (Sweden)

Silvio Bolaños-Salvatierra

2003-01-01

Full Text Available En este documento se rebaten críticas hechas por Raventós y Jensen al artículo “Genética y comportamiento”. Cuatro temas fueron seleccionados: 1 se determina que los antipsicóticos aparecieron veinte años después de la concepción hereditaria de la esquizofrenia; 2 se considera que la discusión es altamente pertinente, para nada bizantina o irrelevante, debido que persisten prácticas epistémicas riesgosas en los investigadores genético-conductuales; 3 aunque ninguna conducta humana está exenta de influencia constitucional, el enfoque biologicista se ha propasado al pretender explicar genéticamente casi todo, desconfirmando solapadamente la importancia de la historia personal; y, 4 se plantea que la investigación biológica sobrevalora el peso de las anomalías genéticas frente a la historia social, por lo que solo aparenta cautela. Se propone investigar genéticamente la esperanza con el objetivo de saturar a la humanidad con ese tipo de explicaciones, para alcanzar más rápido una convivencia basada en la tolerancia y el respeto.

DEMONSTRATION OF A NO-VOC/NO-HAP WOOD KITCHEN CABINET COATING SYSTEM

Science.gov (United States)

The report gives results of the development and demonstration of a no-VOC (volatile organic compound)/no-HAP (hazardous air pollutant) wood furniture coating system at two cabinet manufacturing plants: one in Portland, OR, and the other in Redwood City, CA. Technology transfer ef...

A cancer-associated RING finger protein, RNF43, is a ubiquitin ligase that interacts with a nuclear protein, HAP95

International Nuclear Information System (INIS)

Sugiura, Takeyuki; Yamaguchi, Aya; Miyamoto, Kentaro

2008-01-01

RNF43 is a recently discovered RING finger protein that is implicated in colon cancer pathogenesis. This protein possesses growth-promoting activity but its mechanism remains unknown. In this study, to gain insight into the biological action of RNF43 we characterized it biochemically and intracellularly. A combination of indirect immunofluorescence analysis and biochemical fractionation experiments suggests that RNF43 resides in the endoplasmic reticulum (ER) as well as in the nuclear envelope. Sucrose density gradient fractionation demonstrates that RNF43 co-exists with emerin, a representative inner nuclear membrane protein in the nuclear subcompartment. The cell-free system with pure components reveals that recombinant RNF43 fused with maltose-binding protein has autoubiquitylation activity. By the yeast two-hybrid screening we identified HAP95, a chromatin-associated protein interfacing the nuclear envelope, as an RNF43-interacting protein and substantiated this interaction in intact cells by the co-immunoprecipitation experiments. HAP95 is ubiquitylated and subjected to a proteasome-dependent degradation pathway, however, the experiments in which 293 cells expressing both RNF43 and HAP95 were treated with a proteasome inhibitor, MG132, show that HAP95 is unlikely to serve as a substrate of RNF43 ubiquitin ligase. These results infer that RNF43 is a resident protein of the ER and, at least partially, the nuclear membrane, with ubiquitin ligase activity and may be involved in cell growth control potentially through the interaction with HAP95

40 CFR Table 14 to Subpart Uuu of... - Continuous Compliance With Operating Limits for Organic HAP Emissions From Catalytic Cracking Units

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 12 2010-07-01 2010-07-01 true Continuous Compliance With Operating Limits for Organic HAP Emissions From Catalytic Cracking Units 14 Table 14 to Subpart UUU of Part 63... Compliance With Operating Limits for Organic HAP Emissions From Catalytic Cracking Units As stated in § 63...

40 CFR Table 21 to Subpart Uuu of... - Continuous Compliance With Operating Limits for Organic HAP Emissions From Catalytic Reforming Units

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 12 2010-07-01 2010-07-01 true Continuous Compliance With Operating Limits for Organic HAP Emissions From Catalytic Reforming Units 21 Table 21 to Subpart UUU of Part 63... Compliance With Operating Limits for Organic HAP Emissions From Catalytic Reforming Units As stated in § 63...

Arnold Roosendaal, Digital Personae and Profiles in Law. Protecting Individuals’ Rights in Online Contexts [Bespreking van: Digital Personae and Profiles in Law

NARCIS (Netherlands)

Lodder, A.R.

2014-01-01

Op 21 mei 2013 verdedigde Arnold Roosendaal aan de Universiteit Tilburg zijn proefschrift Digital Personae and Profiles in Law, promotoren waren Ronald Leenes en Bert-Jaap Koops. In de openingszin wordt het belang van het proefschrift direct duidelijk: “Personal data is the new oil of the Internet

Effects of water stress on germination of Pinus nigra Arnold. seeds

International Nuclear Information System (INIS)

Topacoglu, O.; Sevik, H.; Akkuzu, E.

2016-01-01

Climate change, global warming and the deterioration of related environmental conditions cause an important problem for forest tree species. For this reason, it is necessary to determine the response of trees to these conditions. The Objective of this study was to investigate the effects of water stress on seed germination of fifteen Pinus nigra Arnold. provenances in Turkey. For this purpose, the water stresses between 0 and -8.0 bars were obtained using polyethylene glycol-6000 (PEG) solutions. Seeds were kept for 35 days at 20 ± 0.5 degree C. In this study, significant variations between the provenances were found. Ankara Uluhan ( percent 95, 08) and Isparta Tota ( percent 85, 41) provenances at -8.0 bars having the highest cumulative germination percentages were the most resistant provenances against the water stress. This study has shown that the water stress reduced the germination speed, germination percentage and germination value. (author)

40 CFR Table 7 to Subpart Uuu of... - Continuous Compliance With Operating Limits for Metal HAP Emissions From Catalytic Cracking Units

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 12 2010-07-01 2010-07-01 true Continuous Compliance With Operating Limits for Metal HAP Emissions From Catalytic Cracking Units 7 Table 7 to Subpart UUU of Part 63... With Operating Limits for Metal HAP Emissions From Catalytic Cracking Units As stated in § 63.1564(c)(1...

40 CFR Table 3 to Subpart Wwww of... - Organic HAP Emissions Limits for Existing Open Molding Sources, New Open Molding Sources Emitting...

Science.gov (United States)

2010-07-01

.../ton.4 Use the appropriate open molding emission limit.5 9. pultrusion 6 N/A reduce total organic HAP... CATEGORIES National Emissions Standards for Hazardous Air Pollutants: Reinforced Plastic Composites...: If your operation type is . . . And you use . . . 1 Your organic HAP emissions limit is . . . 1. open...

The influence of gamma radiation on the molecular weight and glass transition of PLLA and HAp/PLLA nanocomposite

International Nuclear Information System (INIS)

Milicevic, D.; Trifunovic, S.; Dojcilovic, J.; Ignjatovic, N.; Suljovrujic, E.

2010-01-01

The influence of gamma radiation on the molecular weight and glass transition behaviour of poly-L-lactide (PLLA) and hydroxyapatite/poly-L-lactide (HAp/PLLA) nanocomposite has been studied. Since PLLA exposed to high-energy radiation in the presence of air is prone to chain scission reactions and large degradation, changes in molecular weight were obtained by gel permeation chromatography (GPC). Alterations in the glass transition behaviour were investigated by differential scanning calorimetry (DSC). The apparent activation energy (ΔH*) for glass transition was determined on the basis of the heating rate dependence of the glass transition temperature (T g ). Our findings support the fact that chain scission is the main reason for the decrease of T g and ΔH* with the absorbed dose. Furthermore, more intensive chain scission degradation of PLLA was observed in HAp/PLLA and can only be ascribed to the presence of HAp nanoparticles. Consequently, initial differences in the glass transition temperature and/or apparent activation energy of PLLA and HAp/PLLA became more pronounced with absorbed dose. This study reveals that radiation-induced changes in molecular weight and glass transition temperature occur in a predictable and fairly accurate manner. Therefore, gamma radiation can be used not only for sterilization but also for tailoring desirable end-use properties of these biomaterials.

40 CFR Table 2 to Subpart Ooo of... - Known Organic Hazardous Air Pollutants (HAP) From the Manufacture of Amino/Phenolic Resins

Science.gov (United States)

2010-07-01

... (HAP) From the Manufacture of Amino/Phenolic Resins 2 Table 2 to Subpart OOO of Part 63 Protection of... Pollutant Emissions: Manufacture of Amino/Phenolic Resins Pt. 63, Subpt. OOO, Table 2 Table 2 to Subpart OOO of Part 63—Known Organic Hazardous Air Pollutants (HAP) From the Manufacture of Amino/Phenolic Resins...

An Evaluation of Interference Mitigation Schemes for HAPS Systems

Directory of Open Access Journals (Sweden)

Kim Nam

2008-01-01

Full Text Available Abstract The International Telecommunication Union-Radiocommunication sector (ITU-R has conducted frequency sharing studies between fixed services (FSs using a high altitude platform station (HAPS and fixed-satellite services (FSSs. In particular, ITU-R has investigated the power limitations related to HAPS user terminals (HUTs to facilitate frequency sharing with space station receivers. To reduce the level of interference from the HUTs that can harm a geostationary earth orbit (GEO satellite receiver in a space station, previous studies have taken two approaches: frequency sharing using a separated distance (FSSD and frequency sharing using power control (FSPC. In this paper, various performance evaluation results of interference mitigation schemes are presented. The results include performance evaluations using a new interference mitigation approach as well as conventional approaches. An adaptive beamforming scheme (ABS is introduced as a new scheme for efficient frequency sharing, and the interference mitigation effect on the ABS is examined considering pointing mismatch errors. The results confirm that the application of ABS enables frequency sharing between two systems with a smaller power reduction of HUTs in a cocoverage area compared to this reduction when conventional schemes are utilized. In addition, the analysis results provide the proper amount of modification at the transmitting power level of the HUT required for the suitable frequency sharing.

Genética e hanseníase

Directory of Open Access Journals (Sweden)

Bernardo Beiguelman

Full Text Available As diferentes linhas de pesquisa utilizadas para investigar a importância dos fatores hereditários humanos na determinação da resistência/suscetibilidade à infecção pelo Mycobacterium leprae foram discutidas no presente trabalho. Uma síntese dessas abordagens permitiu analisar os resultados das investigações sobre associação da hanseníase com polimorfismos genéticos, distribuição familial da hanseníase, prevalência da hanseníase e distância genética, concordância da hanseníase em gêmeos e estudos genéticos sobre a reação de Mitsuda.

Genética de la preeclampsia: una aproximación a los estudios de ligamiento genético.

Directory of Open Access Journals (Sweden)

Nora Alejandra Zuluaga

2004-06-01

Full Text Available La preeclampsia es considerada un problema de salud pública debido a su alta prevalencia. Muchas investigaciones coinciden en que su origen se relaciona con la interacción entre factores genéticos y ambientales. Por esta razón, múltiples estudios han explorado tales factores genéticos tratando de identificar regiones cromosómicas y genes candidatos cuyas variantes se relacionen con una mayor susceptibilidad a la enfermedad. Diversos estudios de asociación han identificado algunos genes de susceptibilidad a la preeclampsia, pero los resultados no se han replicado consistentemente en todas las poblaciones, quizá por su complejidad clínica y genética. El levantamiento de mapas de genes y regiones cromosómicas basado en análisis de ligamiento ha mostrado resultados interesantes con algunos marcadores en los cromosomas 2 y 4. En este sentido, hay muchas expectativas con respecto a los genes localizados en tales regiones candidatas, debido a que la identificación de los factores de riesgo genético podría ayudar al entendimiento de esta condición y en proveer claves para su prevención y tratamiento.

Divergence and genetic variability among superior rubber tree genotypes Divergência e variabilidade genética de genótipos superiores de seringueira

Directory of Open Access Journals (Sweden)

Lígia Regina Lima Gouvêa

2010-02-01

Full Text Available The objective of this work was to estimate the genetic variability and divergence among 22 superior rubber tree (Hevea sp. genotypes of the IAC 400 series. Univariate and multivariate analyses were performed using eight quantitative traits (descriptors, including yield. In the univariate analyses, the estimated parameters were: genetic and environmental variances; genetic and environmental coefficients of variation; and the variation index. The Mahalanobis generalized distance, the Tocher agglomerative method and canonical variables were used for the multivariate analyses. In the univariate analyses, variability was verified among the genotypes for all the variables evaluated. The Tocher method grouped the genotypes into 11 clusters of dissimilarity. The first four canonical variables explained 87.93% of the cumulative variation. The highest genetic variability was found in rubber yield-related traits, which contributed the most to the genetic divergence. The most divergent pairs of genotypes are suggested for crossbreeding. The genotypes evaluated are suitable for breeding and may be used to continue the IAC rubber tree breeding program.O objetivo deste trabalho foi estimar a divergência e a variabilidade genética entre 22 genótipos superiores de seringueira (Hevea sp. da série IAC 400. Análises univariadas e multivariadas foram realizadas com oito caracteres quantitativos (descritores, incluindo produtividade. Na análise univariada, os parâmetros estimados foram: variâncias genética e ambiental, coeficientes de variação genética e ambiental, e índice de variação. A distância generalizada de Mahalanobis, o método aglomerativo de Tocher e variáveis canônicas foram utilizados nas análises multivariadas. Nas análises univariadas, verificou-se variabilidade entre os genótipos para todas as variáveis avaliadas. O método de Tocher agrupou os genótipos em 11 grupos de dissimilaridade. As quatro primeiras variáveis can

Estructura y diversidad genética en vacas Holstein de Antioquia usando un polimorfismo del gen bGH

Directory of Open Access Journals (Sweden)

Juan Rincon F.

2013-03-01

Full Text Available Objetivo. Determinar las frecuencias alélicas y genotípicas del polimorfismo del intrón 3 del gen bGH y estimar algunos parámetros de estructura poblacional en ganado Holstein. Materiales y métodos. El estudio se realizó con 1366 vacas Holstein en 120 hatos de 11 municipios del departamento de Antioquia. Se extrajo DNA por el método de Salting out y la genotipificación se realizó usando la técnica de PCR-RFLPs. La diversidad genética se determinó mediante la comparación de las heterocigosidades, El equilibrio de Hardy-Weinberg (HW y la diferenciación genética entre las poblaciones se realizó usando el software Arlequín 2.0 Las frecuencias alélicas y genotípicas se evaluaron mediante el paquete estadístico SAS®. Resultados. Las frecuencias genotípicas encontradas fueron 0.764 (+/+, 0.223 (+/- y 0.013 (-/- y las frecuencias alélicas 0.876 (+ y 0.124 (-. No se encontraron desviaciones del Equilibrio de Hardy Weinberg en ninguna de las subpoblaciones. La diversidad genética determinada mediante la comparación de las heterocigosidades fue relativamente baja entre poblaciones pero al interior de estas no. El valor de FST de toda la población fue de 0.0068 y significativo (p<0.05, algunos FST pareados también lo fueron, tomando valores desde 0.0 a 0.13. Los estadísticos FIT y FIS no fueron significativos. Conclusiones. El gen bGH es un candidato interesante para evaluar características de importancia económica ya que no parece haber sido sometido a selección directa, presenta una variabilidad media en las poblaciones, observándose diferenciación genética significativa entre distintos municipios, producto de los diferentes sistemas de producción y acceso a las biotecnologías.

Next Gen One Portal Usability Evaluation

Science.gov (United States)

Cross, E. V., III; Perera, J. S.; Hanson, A. M.; English, K.; Vu, L.; Amonette, W.

2018-01-01

Each exercise device on the International Space Station (ISS) has a unique, customized software system interface with unique layouts / hierarchy, and operational principles that require significant crew training. Furthermore, the software programs are not adaptable and provide no real-time feedback or motivation to enhance the exercise experience and/or prevent injuries. Additionally, the graphical user interfaces (GUI) of these systems present information through multiple layers resulting in difficulty navigating to the desired screens and functions. These limitations of current exercise device GUI's lead to increased crew time spent on initiating, loading, performing exercises, logging data and exiting the system. To address these limitations a Next Generation One Portal (NextGen One Portal) Crew Countermeasure System (CMS) was developed, which utilizes the latest industry guidelines in GUI designs to provide an intuitive ease of use approach (i.e., 80% of the functionality gained within 5-10 minutes of initial use without/limited formal training required). This is accomplished by providing a consistent interface using common software to reduce crew training, increase efficiency & user satisfaction while also reducing development & maintenance costs. Results from the usability evaluations showed the NextGen One Portal UI having greater efficiency, learnability, memorability, usability and overall user experience than the current Advanced Resistive Exercise Device (ARED) UI used by astronauts on ISS. Specifically, the design of the One-Portal UI as an app interface similar to those found on the Apple and Google's App Store, assisted many of the participants in grasping the concepts of the interface with minimum training. Although the NextGen One-Portal UI was shown to be an overall better interface, observations by the test facilitators noted specific exercise tasks appeared to have a significant impact on the NextGen One-Portal UI efficiency. Future updates to

Salud pública, genética y ética

Directory of Open Access Journals (Sweden)

Kottow Miguel H

2002-01-01

Full Text Available La investigación genética ha tenido una enorme expansión en recientes décadas, con repercusiones terapéuticas aún inciertas. El análisis bioético tradicional de las complejas prácticas genéticas ha sido insuficiente por sostenerse en la ética de la investigación y en la bioética de corte principialista. Los problemas éticos más importantes de la genética son de orden colectivo y deben ser abordados por una reflexión ético-social cuyo enfoque es más amplio que la agenda interpersonal del principialismo. Temas como exploraciones genéticas, cuestiones patrimoniales, manipulación génica y asignación de recursos, deben todos ser sometidos a un pensamiento inspirado en los requerimientos de la ciudadanía, en el bien común y en la definición del rol del Estado en fiscalizar actividades genéticas y en proteger a la población. El objetivo del estudio es mostrar cómo el amplio campo de la ética y de la genética tiene una mayor relevancia en el campo social que en el clínico. El objetivo del trabajo es señalar que la bioética principialista ha enfatizado los problemas éticos individuales que nacen con la intervención genética, a costa de marginar sus importantes repercusiones sociales.

Salud pública, genética y ética

Directory of Open Access Journals (Sweden)

Miguel H Kottow

2002-10-01

Full Text Available La investigación genética ha tenido una enorme expansión en recientes décadas, con repercusiones terapéuticas aún inciertas. El análisis bioético tradicional de las complejas prácticas genéticas ha sido insuficiente por sostenerse en la ética de la investigación y en la bioética de corte principialista. Los problemas éticos más importantes de la genética son de orden colectivo y deben ser abordados por una reflexión ético-social cuyo enfoque es más amplio que la agenda interpersonal del principialismo. Temas como exploraciones genéticas, cuestiones patrimoniales, manipulación génica y asignación de recursos, deben todos ser sometidos a un pensamiento inspirado en los requerimientos de la ciudadanía, en el bien común y en la definición del rol del Estado en fiscalizar actividades genéticas y en proteger a la población. El objetivo del estudio es mostrar cómo el amplio campo de la ética y de la genética tiene una mayor relevancia en el campo social que en el clínico. El objetivo del trabajo es señalar que la bioética principialista ha enfatizado los problemas éticos individuales que nacen con la intervención genética, a costa de marginar sus importantes repercusiones sociales.

Analysis of materials of the mural painting 'Los Prometeos' of Arnold Belkin, Managua, Nicaragua

International Nuclear Information System (INIS)

Espinosa, M.E.; Tapia, M.

2004-01-01

Arnold Belkin was one of the most important exponents of the new muralism, in his paintings topics like war, dead, injustice, as well as hope, peace, society transformation and science benefits to the humankind were always related. One of these murals is the 'Los Prometeos' located at Managua, Nicaragua. This mural painting actually is suffering a localized deterioration by weather conditions (humidity) and manufacture techniques. Samples were collected from different spots of mural which shows the deterioration problem, in order to characterized them scanning electron microscopy, energy dispersive X-ray spectroscopy and X-ray diffraction were used to analyzed the soluble salts influences (sulfates and chlorides) in the deterioration mechanism problem. (Author) 9 refs., 10 tabs., 17 figs

Fate of trace element haps when applying mercury control technologies

Energy Technology Data Exchange (ETDEWEB)

Nyberg, Carolyn M.; Thompson, Jeffrey S.; Zhuang, Ye; Pavlish, John H. [University of North Dakota Energy and Environmental Research Center 15 North 23rd Street, Stop 9018, Grand Forks, North Dakota 58202-9018 (United States); Brickett, Lynn; Pletcher, Sara [U.S. Department of Energy National Energy Technology Laboratory 626 Cochrans Mill Road, PO Box 10940, MS 922-273C, Pittsburgh, PA 15236-0940 (United States)

2009-11-15

During the past several years, and particularly since the Clean Air Mercury Rule (CAMR) was promulgated in June of 2005, the electric utility industry, product vendors, and the research community have been working diligently to develop and test Hg control strategies for a variety of coal types and plant configurations. Some of these strategies include sorbent injection and chemical additives designed to increase mercury capture efficiency in particulate control devices. These strategies have the potential to impact the fate of other inorganic hazardous air pollutants (HAPs), which typically include As, Be, Cd, Cr, Co, Mn, Ni, Pb, Se, and Sb. To evaluate this impact, flue gas samples using EPA Method 29, along with representative coal and ash samples, were collected during recent pilot-scale and field test projects that were evaluating Hg control technologies. These test programs included a range of fuel types with varying trace element concentrations, along with different combustion systems and particulate control devices. The results show that the majority of the trace element HAPs are associated with the particulate matter in the flue gas, except for Se. However, for five of the six projects, Se partitioning was shifted to the particulate phase and total emissions reduced when Hg control technologies were applied. (author)

Optimal trading strategy for GenCo in LMP-based and bilateral ...

African Journals Online (AJOL)

cboonchu

GenCo) ... In Li and Shahidehpour (2005), a game-based bidding strategy for GenCos with ..... With the different demands, dispatched levels of GenCos vary as shown in Table 6. .... optimisation, AI applications to power systems, and power system ...

História da genética no Brasil: um olhar a partir do Museu da Genética da Universidade Federal do Rio Grande do Sul

Directory of Open Access Journals (Sweden)

Vanderlei Sebastiao de Souza

2013-06-01

Full Text Available Aborda o contexto de criação do Museu da Genética, em 2011 no Departamento de Genética na Universidade Federal do Rio Grande do Sul, em Porto Alegre, e apresenta sua estrutura e conteúdo. Argumenta-se que os materiais disponibilizados no Museu da Genética constituem uma rica fonte para pesquisas sobre a história da genética no Brasil (e da genética de populações humanas em particular a partir da segunda metade do século XX, tema ainda pouco investigado, apesar da proeminência dessa área do conhecimento no Brasil.

Performance simulation in high altitude platforms (HAPs) communications systems

Science.gov (United States)

Ulloa-Vásquez, Fernando; Delgado-Penin, J. A.

2002-07-01

This paper considers the analysis by simulation of a digital narrowband communication system for an scenario which consists of a High-Altitude aeronautical Platform (HAP) and fixed/mobile terrestrial transceivers. The aeronautical channel is modelled considering geometrical (angle of elevation vs. horizontal distance of the terrestrial reflectors) and statistical arguments and under these circumstances a serial concatenated coded digital transmission is analysed for several hypothesis related to radio-electric coverage areas. The results indicate a good feasibility for the communication system proposed and analysed.

Manipulación genética de seres humanos

Directory of Open Access Journals (Sweden)

Manuel Santos Alcántara

2006-08-01

Full Text Available El gran avance que ha tenido la Genética en los últimos años y, particularmente, aquello relacionado con el desciframiento del genoma humano, ha traído a la discusión pública la posibilidad concreta de manipular genéticamente a los seres humanos. El mejoramiento o perfeccionamiento genético de los seres humanos, denominado eugenesia, actualmente se ha convertido técnicamente en una realidad, motivando una profunda reflexión de tipo ético. La pregunta básica es la siguiente: aquello que es técnicamente posible de realizar ¿es ético hacerlo? ¿Tienen derecho los padres a acceder a la tecnología genética para mejorar las características de sus hijos? En este artículo se revisan las bases científicas del mejoramiento genético de los seres humanos, y se plantean los cuestionamientos éticos más relevantes derivados de esta manipulación.

Programa nacional de prevención y consejería genética del retinoblastoma mediante detección de mutaciones en el gen RB.

Directory of Open Access Journals (Sweden)

H. Frayle

2001-07-01

una la doble mutación inactivante del gen Rb, exclusivamente somática en los esporádicos y germinal más somática en los hereditarios. Esta investigacin tuvo como objetivo caracterizar las mutaciones en el gen Rb mediante secuenciación directa y evaluar su utilidad en la consejería genética.

Large-scale lysimeter site St. Arnold, Germany: analysis of 40 years of precipitation, leachate and evapotranspiration

Directory of Open Access Journals (Sweden)

N. Harsch

2009-03-01

Full Text Available This study deals with a lysimetrical-meteorological data series collected on the large-scale lysimeter site "St. Arnold", Germany, from November 1965 to April 2007. The particular relevance of this data rests both upon its perdurability and upon the fact that the site is comprised of a grassland basin, an oak/beech and a pine basin.

Apart from analyzing long term trends of the meteorological measurements, the primary objective of this study is to investigate the water balance in grassland and forested basins, in particular comparing the precipitation term to leachate quantities and potential and actual evapotranspiration. The latter are based upon the Penman and the Penman-Monteith approaches, respectively.

The main results of this survey are that, on a long-term average, the grassland basin turns more than half (53% of its annually incoming precipitation into leachate and only 36% into water vapour, while the deciduous forest exhibits a ratio of 37% for leachate and 56% for evapotranspiration, and the evergreen coniferous forest shows the highest evaporation rate (65% and the lowest leachate rate (26%.

Concerning these water balances, considerable differences both between basins and between seasons stand out. While summer periods exhibit high evapotranspiration rates for the forests and moderate ones for the grassland, winter periods are characterised by considerable leachate quantities for grassland and the deciduous forest and moderate ones for the coniferous forest. Following the analysis of the climatic development in St. Arnold, trends towards a milder and more humid regional climate were detected.

Programa nacional de prevención y consejería genética del retinoblastoma mediante detección de mutaciones en el gen rb.

OpenAIRE

Frayle, H.; Guevara, G.

2011-01-01

El retinoblastoma es un raro tumor ocular que se diagnostica en los niños, 40% de los casos se consideran hereditarios y 60% esporádicos. El modelo genético propuesto por Knudson involucra
una la doble mutación inactivante del gen Rb, exclusivamente somática en los esporádicos y germinal más somática en los hereditarios. Esta investigacin tuvo como objetivo caracterizar las mutaciones en el gen Rb mediante secuenciación directa y evaluar su utilidad en la consejería genética....

The Antiaircraft Journal. Volume 92, Number 6, November-December 1949

Science.gov (United States)

1949-12-01

Hq., 68th AAA Group, Ft. Ord, Calif. McLean, Donald, Hq., South Post, Ft. Myer, Va. Musselman, Arthur c., 91 Cornwell Ave., Valley Stream, L.I., N. Y...27 Atomic Defense-A Constructive Approach .. , , 6-29 Australia’s Long-Range \\X’eapons Range , 6-40 ANTIAIRCRAFT JOURNAL N...... dP~ B Bernard M...always cool-minded, and as close to being nnal as we are likely ever to get. - BERNARD DE VOTO. General ’Hap’ Arnold’s Memoirs GLOBAL MISSION. By H. H

Justicia en salud y genética

Directory of Open Access Journals (Sweden)

Maria Graciela De Ortuzar

2014-06-01

Full Text Available Las expectativas puestas en el conocimiento genético exceden el ámbito de la medicina tradiciona, debido a que la intervención directa en la lotería natural demandaría el replanteamiento de conceptos centrales de justicia en salud: necesidades médicas, enfermedad, normalidad, e igualdad de oportunidades en el acceso a la salud. El punto en debate es sí el replanteo de dichos conceptos conlleva un cambio radical en las teorías de justicia (libertariana y/o liberal, mostrando su obsolescencia, o sí simplemente se requiere ampliar dichos conceptos claves por fallas estructurales en las mismas teorías. Como hipótesis general considero que los supuestos cuestionamientos, lejos de socavar las bases de las teorías de justicia, sólo ponen en evidencia sus viejos problemas estructurales. Por razones expositivas, dividiré la presentación tres partes. En la Primera parte, analizo la teoría libertariana, estudiando las contradicciones del modelo a través del impacto de la información genética en el seguro privado de salud. En la Segunda Parte, desarrollo la propuesta alternativa liberal rawlsianadanielsiana del modelo de seguro público, evaluando las implicaciones de la genética a partir de la crítica de su concepto biológico de enfermedad y su restricción al acceso a la salud por necesidades naturales. En la Tercera parte presento un modelo integral de necesidades y capacidades básicas, comprendiendo la prevención, el tratamiento y el mejoramiento moralmente permisible (genético y no genético.Mi aporte principal consiste en la elaboración de este modelo normativo integral de necesidades y capacidades para la regulación conjunta de la información y terapia genética con los restantes problemas de salud.

HapHop-Physio: a computer game to support cognitive therapies in children

Directory of Open Access Journals (Sweden)

Rico-Olarte C

2017-07-01

Full Text Available Carolina Rico-Olarte,1 Diego M López,1 Santiago Narváez,1 Charic D Farinango,1 Peter S Pharow2 1Faculty of Electronics and Telecommunications Engineering, Universidad del Cauca, Telematics Engineering Research Group, Popayán, Colombia; 2Fraunhofer Institute of Digital Media and Technology IDMT, Ilmenau, Germany Background: Care and support of children with physical or mental disabilities are accompanied with serious concerns for parents, families, healthcare institutions, schools, and their communities. Recent studies and technological innovations have demonstrated the feasibility of providing therapy and rehabilitation services to children supported by computer games. Objective: The aim of this paper is to present HapHop-Physio, an innovative computer game that combines exercise with fun and learning, developed to support cognitive therapies in children. Methods: Conventional software engineering methods such as the Scrum methodology, a functionality test and a related usability test, were part of the comprehensive methodology adapted to develop HapHop-Physio. Results: The game supports visual and auditory attention therapies, as well as visual and auditory memory activities. The game was developed by a multidisciplinary team, which was based on the Hopscotch® platform provided by Fraunhofer Institute for Digital Media Technology IDMT Institute in Germany, and designed in collaboration with a rehabilitation clinic in Colombia. HapHop-Physio was tested and evaluated to probe its functionality and user satisfaction. Conclusion: The results show the development of an easy-to-use and funny game by a multidisciplinary team using state-of-the-art videogame technologies and software methodologies. Children testing the game concluded that they would like to play again while undergoing rehabilitation therapies. Keywords: computer game, exer-games, cognitive therapies, rehabilitation

Southern Vermont College (SVC) and Wheelock College (WC): 2010 Urban and Rural Healthcare Academy Program (HAP) for College Progress and Workforce Development

Science.gov (United States)

DeCiccio, Albert C.

2010-01-01

(Purpose) This is a report about the Urban and Rural Healthcare Academy Pilot Program (HAP) that launched at Southern Vermont College (SVC) and Wheelock College (WC) in summer 2010. HAP enabled 18 vulnerable high school students to learn about how to progress to college, how to transition when they arrive on a college campus, and how to prepare…

Nuclear magnetic resonance (NMR) imaging of Arnold-Chiari type I malformation with hydromyelia

International Nuclear Information System (INIS)

DeLaPaz, R.L.; Brady, T.J.; Buonanno, F.S.; New, P.F.; Kistler, J.P.; McGinnis, B.D.; Pykett, I.L.; Taveras, J.M.

1983-01-01

Saturation recovery nuclear magnetic resonance (NMR) images and metrizamide computed tomography (CT) scans were obtained in an adult patient with a clinical history suggestive of syringomyelia. Both NMR and CT studies showed low lying cerebellar tonsils. The CT study demonstrated central cavitation of the spinal cord from the midthoracic to midcervical levels but could not exclude an intramedullary soft tissue mass at the cervico-medullary junction. The NMR images in transverse, coronal, and sagittal planes demonstrated extension of an enlarged central spinal cord cerebrospinal fluid space to the cervico-medullary junction. This was felt to be strong evidence for exclusion of an intramedullary soft tissue mass and in favor of a diagnosis of Arnold-Chiari Type I malformation with hydromyelia. The noninvasive nature of spinal cord and cervico-medullary junction evaluation with NMR is emphasized

Evaluation of environmental data relating to selected nuclear power plant sites. The Duane Arnold Energy Center site

International Nuclear Information System (INIS)

Vaslow, F.; Murarka, I.P.

1976-08-01

Analyses were made on 1974-1975 data pertaining to water quality and the use of biocides at the Duane Arnold Energy Center, which began operating in February 1975. The analyses showed no immediate deleterious effects due to plant operations. Although the plant has not been in operation long enough to reveal any long-term deleterious effects, present indications do not lead to a concerned prediction that any are developing. The data utilized, the methods of analysis, and the results obtained are presented in detail along with recommendations for improving the current monitoring techniques

An evaluation of the performance of tag SNPs derived from HapMap in a Caucasian population.

Directory of Open Access Journals (Sweden)

Alexandre Montpetit

2006-03-01

Full Text Available The Haplotype Map (HapMap project recently generated genotype data for more than 1 million single-nucleotide polymorphisms (SNPs in four population samples. The main application of the data is in the selection of tag single-nucleotide polymorphisms (tSNPs to use in association studies. The usefulness of this selection process needs to be verified in populations outside those used for the HapMap project. In addition, it is not known how well the data represent the general population, as only 90-120 chromosomes were used for each population and since the genotyped SNPs were selected so as to have high frequencies. In this study, we analyzed more than 1,000 individuals from Estonia. The population of this northern European country has been influenced by many different waves of migrations from Europe and Russia. We genotyped 1,536 randomly selected SNPs from two 500-kbp ENCODE regions on Chromosome 2. We observed that the tSNPs selected from the CEPH (Centre d'Etude du Polymorphisme Humain from Utah (CEU HapMap samples (derived from US residents with northern and western European ancestry captured most of the variation in the Estonia sample. (Between 90% and 95% of the SNPs with a minor allele frequency of more than 5% have an r2 of at least 0.8 with one of the CEU tSNPs. Using the reverse approach, tags selected from the Estonia sample could almost equally well describe the CEU sample. Finally, we observed that the sample size, the allelic frequency, and the SNP density in the dataset used to select the tags each have important effects on the tagging performance. Overall, our study supports the use of HapMap data in other Caucasian populations, but the SNP density and the bias towards high-frequency SNPs have to be taken into account when designing association studies.

GenBank.

OpenAIRE

Benson, D; Lipman, D J; Ostell, J

1993-01-01

The GenBank sequence database has undergone an expansion in data coverage, annotation content and the development of new services for the scientific community. In addition to nucleotide sequences, data from the major protein sequence and structural databases, and from U.S. and European patents is now included in an integrated system. MEDLINE abstracts from published articles describing the sequences provide an important new source of biological annotation for sequence entries. In addition to ...

Gen IV Materials Handbook Implementation Plan

International Nuclear Information System (INIS)

Rittenhouse, P.; Ren, W.

2005-01-01

A Gen IV Materials Handbook is being developed to provide an authoritative single source of highly qualified structural materials information and materials properties data for use in design and analyses of all Generation IV Reactor Systems. The Handbook will be responsive to the needs expressed by all of the principal government, national laboratory, and private company stakeholders of Gen IV Reactor Systems. The Gen IV Materials Handbook Implementation Plan provided here addresses the purpose, rationale, attributes, and benefits of the Handbook and will detail its content, format, quality assurance, applicability, and access. Structural materials, both metallic and ceramic, for all Gen IV reactor types currently supported by the Department of Energy (DOE) will be included in the Gen IV Materials Handbook. However, initial emphasis will be on materials for the Very High Temperature Reactor (VHTR). Descriptive information (e.g., chemical composition and applicable technical specifications and codes) will be provided for each material along with an extensive presentation of mechanical and physical property data including consideration of temperature, irradiation, environment, etc. effects on properties. Access to the Gen IV Materials Handbook will be internet-based with appropriate levels of control. Information and data in the Handbook will be configured to allow search by material classes, specific materials, specific information or property class, specific property, data parameters, and individual data points identified with materials parameters, test conditions, and data source. Details on all of these as well as proposed applicability and consideration of data quality classes are provided in the Implementation Plan. Website development for the Handbook is divided into six phases including (1) detailed product analysis and specification, (2) simulation and design, (3) implementation and testing, (4) product release, (5) project/product evaluation, and (6) product

Future aerospace ground test facility requirements for the Arnold Engineering Development Center

Science.gov (United States)

Kirchner, Mark E.; Baron, Judson R.; Bogdonoff, Seymour M.; Carter, Donald I.; Couch, Lana M.; Fanning, Arthur E.; Heiser, William H.; Koff, Bernard L.; Melnik, Robert E.; Mercer, Stephen C.

1992-01-01

Arnold Engineering Development Center (AEDC) was conceived at the close of World War II, when major new developments in flight technology were presaged by new aerodynamic and propulsion concepts. During the past 40 years, AEDC has played a significant part in the development of many aerospace systems. The original plans were extended through the years by some additional facilities, particularly in the area of propulsion testing. AEDC now has undertaken development of a master plan in an attempt to project requirements and to plan for ground test and computational facilities over the coming 20 to 30 years. This report was prepared in response to an AEDC request that the National Research Council (NRC) assemble a committee to prepare guidance for planning and modernizing AEDC facilities for the development and testing of future classes of aerospace systems as envisaged by the U.S. Air Force.

Algoritmos para genómica comparativa

OpenAIRE

Figueiras, Vasco da Rocha

2010-01-01

Com o surgimento da Genómica e da Proteómica, a Bioinformática conduziu a alguns dos avanços científicos mais relevantes do século XX. A Unidade de Investigação e Desenvolvimento do Biocant, parque biotecnológico de Cantanhede, assume actualmente o papel de motor no desenvolvimento da Genómica. O Biocant possui um importante sequenciador de larga escala que permite armazenar um elevado número de genomas, nomeadamente, genomas de bactérias. O estudo proposto reflecte a necessidade do Bio...

Energy-Efficient Transmissions for Remote Wireless Sensor Networks: An Integrated HAP/Satellite Architecture for Emergency Scenarios.

Science.gov (United States)

Dong, Feihong; Li, Hongjun; Gong, Xiangwu; Liu, Quan; Wang, Jingchao

2015-09-03

A typical application scenario of remote wireless sensor networks (WSNs) is identified as an emergency scenario. One of the greatest design challenges for communications in emergency scenarios is energy-efficient transmission, due to scarce electrical energy in large-scale natural and man-made disasters. Integrated high altitude platform (HAP)/satellite networks are expected to optimally meet emergency communication requirements. In this paper, a novel integrated HAP/satellite (IHS) architecture is proposed, and three segments of the architecture are investigated in detail. The concept of link-state advertisement (LSA) is designed in a slow flat Rician fading channel. The LSA is received and processed by the terminal to estimate the link state information, which can significantly reduce the energy consumption at the terminal end. Furthermore, the transmission power requirements of the HAPs and terminals are derived using the gradient descent and differential equation methods. The energy consumption is modeled at both the source and system level. An innovative and adaptive algorithm is given for the energy-efficient path selection. The simulation results validate the effectiveness of the proposed adaptive algorithm. It is shown that the proposed adaptive algorithm can significantly improve energy efficiency when combined with the LSA and the energy consumption estimation.

Energy-Efficient Transmissions for Remote Wireless Sensor Networks: An Integrated HAP/Satellite Architecture for Emergency Scenarios

Science.gov (United States)

Dong, Feihong; Li, Hongjun; Gong, Xiangwu; Liu, Quan; Wang, Jingchao

2015-01-01

A typical application scenario of remote wireless sensor networks (WSNs) is identified as an emergency scenario. One of the greatest design challenges for communications in emergency scenarios is energy-efficient transmission, due to scarce electrical energy in large-scale natural and man-made disasters. Integrated high altitude platform (HAP)/satellite networks are expected to optimally meet emergency communication requirements. In this paper, a novel integrated HAP/satellite (IHS) architecture is proposed, and three segments of the architecture are investigated in detail. The concept of link-state advertisement (LSA) is designed in a slow flat Rician fading channel. The LSA is received and processed by the terminal to estimate the link state information, which can significantly reduce the energy consumption at the terminal end. Furthermore, the transmission power requirements of the HAPs and terminals are derived using the gradient descent and differential equation methods. The energy consumption is modeled at both the source and system level. An innovative and adaptive algorithm is given for the energy-efficient path selection. The simulation results validate the effectiveness of the proposed adaptive algorithm. It is shown that the proposed adaptive algorithm can significantly improve energy efficiency when combined with the LSA and the energy consumption estimation. PMID:26404292

Energy-Efficient Transmissions for Remote Wireless Sensor Networks: An Integrated HAP/Satellite Architecture for Emergency Scenarios

Directory of Open Access Journals (Sweden)

Feihong Dong

2015-09-01

Full Text Available A typical application scenario of remote wireless sensor networks (WSNs is identified as an emergency scenario. One of the greatest design challenges for communications in emergency scenarios is energy-efficient transmission, due to scarce electrical energy in large-scale natural and man-made disasters. Integrated high altitude platform (HAP/satellite networks are expected to optimally meet emergency communication requirements. In this paper, a novel integrated HAP/satellite (IHS architecture is proposed, and three segments of the architecture are investigated in detail. The concept of link-state advertisement (LSA is designed in a slow flat Rician fading channel. The LSA is received and processed by the terminal to estimate the link state information, which can significantly reduce the energy consumption at the terminal end. Furthermore, the transmission power requirements of the HAPs and terminals are derived using the gradient descent and differential equation methods. The energy consumption is modeled at both the source and system level. An innovative and adaptive algorithm is given for the energy-efficient path selection. The simulation results validate the effectiveness of the proposed adaptive algorithm. It is shown that the proposed adaptive algorithm can significantly improve energy efficiency when combined with the LSA and the energy consumption estimation.

Medicamentos genéricos y de marca-Calidad e intercambiabilidad

Directory of Open Access Journals (Sweden)

Rua F.

2012-03-01

Full Text Available El interés por los medicamentos genéricos procede de la necesidad de los sistemas sanitarios de reducir la factura sanitaria sin merma de los objetivos de salud. Su expansión y uso requieren la aceptación de la población y de los profesionales. También requieren que se despejen algunas dudas sobre su verdadera equivalencia respecto a los medicamentos originales. Desde su introducción en el mercado farmacéutico existe el debate de si son correctamente investigados y de alta calidad. No son infrecuentes los conceptos equivocados entre los profesionales sobre los genéricos, en especial, el supuesto hecho de que pueden llegar a contener hasta un 20% menos de concentración en principio activo. Estas creencias erróneas sugieren una situación de desventaja en la eficacia y la tolerabilidad de los medicamentos genéricos comparados con sus equivalentes de marca, disminuyendo la credibilidad de los mismos. Así, en una encuesta realizada en 2008 los farmacéuticos opinaron que los genéricos y las marcas son diferentes en eficacia (26%, equivalencia (28% y, sobre todo, en la calidad del excipiente (46%, aumentando la percepción de que los genéricos son diferentes en función del laboratorio que los fabrica (52,8%. En este artículo, con el fin de ampliar los conocimientos sobre medicamentos genéricos, solucionar dudas y proporcionar información, objetiva, clara y rigurosa, se revisan los posibles prejuicios sobre genéricos y se exponen las evidencias que existen en torno a los mismos, como los requisitos de bioequivalencia de los productos genéricos, analizando si ésta corrobora adecuadamente la equivalencia terapéutica y de intercambio.

40 CFR Table 1 to Subpart III of... - HAP ABA Formulation Limitations Matrix for New Sources [see § 63.1297(d)(2)

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 11 2010-07-01 2010-07-01 true HAP ABA Formulation Limitations Matrix for New Sources [see § 63.1297(d)(2)] 1 Table 1 to Subpart III of Part 63 Protection of Environment... Flexible Polyurethane Foam Production Pt. 63, Subpt. III, Table 1 Table 1 to Subpart III of Part 63—HAP ABA...

Sobre el significado del descubrimiento del gen FOXP2

OpenAIRE

Longa Martínez, Víctor Manuel

2006-01-01

El reciente descubrimiento del gen FOXP2 ha ofrecido la primera evidencia clara de la base genética del lenguaje, mostrando una correlación inequívoca desde la perspectiva genética entre una versión mutada de F0XP2 y los trastornos lingüísticos de diferente tipo sufridos por una familia inglesa, conocida como KE. El objetivo central del presente trabajo es discutir diferentes aspectos relacionados con tal descubrimiento; especialmente, la discusión del significado de FOXP2 con ...

Building Entry Loss and Delay Spread Measurements on a Simulated HAP-to-Indoor Link at S-Band

Directory of Open Access Journals (Sweden)

Delgado-Penín JA

2008-01-01

Full Text Available Results from a measurement campaign emulating the high altitude platform (HAP-to-indoor communication channel at S-band are presented in this paper. A link was established between a transmitter carried by a helicopter, representing the HAP, and a receiver placed at several locations in different building types including an airport, an office building, a shopping mall, a residential house, and a skyscraper. A wideband, directive channel sounder was used to measure building entry loss and time delay spread. Results of the building entry loss are presented as a function of building type, elevation, and building entry angle. Results of delay spread for each building are also provided.

Building Entry Loss and Delay Spread Measurements on a Simulated HAP-to-Indoor Link at S-Band

Directory of Open Access Journals (Sweden)

P. Valtr

2008-07-01

Full Text Available Results from a measurement campaign emulating the high altitude platform (HAP-to-indoor communication channel at S-band are presented in this paper. A link was established between a transmitter carried by a helicopter, representing the HAP, and a receiver placed at several locations in different building types including an airport, an office building, a shopping mall, a residential house, and a skyscraper. A wideband, directive channel sounder was used to measure building entry loss and time delay spread. Results of the building entry loss are presented as a function of building type, elevation, and building entry angle. Results of delay spread for each building are also provided.

Distributed Generation Market Demand Model (dGen): Documentation

Energy Technology Data Exchange (ETDEWEB)

Sigrin, Benjamin [National Renewable Energy Lab. (NREL), Golden, CO (United States); Gleason, Michael [National Renewable Energy Lab. (NREL), Golden, CO (United States); Preus, Robert [National Renewable Energy Lab. (NREL), Golden, CO (United States); Baring-Gould, Ian [National Renewable Energy Lab. (NREL), Golden, CO (United States); Margolis, Robert [National Renewable Energy Lab. (NREL), Golden, CO (United States)

2016-02-01

The Distributed Generation Market Demand model (dGen) is a geospatially rich, bottom-up, market-penetration model that simulates the potential adoption of distributed energy resources (DERs) for residential, commercial, and industrial entities in the continental United States through 2050. The National Renewable Energy Laboratory (NREL) developed dGen to analyze the key factors that will affect future market demand for distributed solar, wind, storage, and other DER technologies in the United States. The new model builds off, extends, and replaces NREL's SolarDS model (Denholm et al. 2009a), which simulates the market penetration of distributed PV only. Unlike the SolarDS model, dGen can model various DER technologies under one platform--it currently can simulate the adoption of distributed solar (the dSolar module) and distributed wind (the dWind module) and link with the ReEDS capacity expansion model (Appendix C). The underlying algorithms and datasets in dGen, which improve the representation of customer decision making as well as the spatial resolution of analyses (Figure ES-1), also are improvements over SolarDS.

Revision of Corallinaceae (Corallinales, Rhodophyta): recognizing Dawsoniolithon gen. nov., Parvicellularium gen. nov. and Chamberlainoideae subfam. nov. containing Chamberlainium gen. nov. and Pneophyllum.

Science.gov (United States)

Caragnano, Annalisa; Foetisch, Alexandra; Maneveldt, Gavin W; Millet, Laurent; Liu, Li-Chia; Lin, Showe-Mei; Rodondi, Graziella; Payri, Claude E

2018-03-25

A multi-gene (SSU, LSU, psbA and COI) molecular phylogeny of the family Corallinaceae (excluding the subfamilies Lithophylloideae and Corallinoideae) showed a paraphyletic grouping of six monophyletic clades. Pneophyllum and Spongites were reassessed and recircumscribed using DNA sequence data integrated with morpho-anatomical comparisons of type material and recently collected specimens. We propose Chamberlainoideae subfam. nov., including the type genus Chamberlainium gen. nov., with C. tumidum comb. nov. as the generitype, and Pneophyllum. Chamberlainium is established to include several taxa previously ascribed to Spongites, the generitype of which currently resides in Neogoniolithoideae. Additionally we propose two new genera, Dawsoniolithon gen. nov. (Metagoniolithoideae), with D. conicum comb. nov. as the generitype and Parvicellularium gen. nov. (subfamily incertae sedis), with P. leonardi sp. nov. as the generitype. Chamberlainoideae has no diagnostic morpho-anatomical features that enable one to assign specimens to it without DNA sequence data, and it is the first subfamily to possess both Type 1 (Chamberlainium) and Type 2 (Pneophyllum) tetra/bisporangial conceptacle roof development. Two characters distinguish Chamberlainium from Spongites: tetra/biasporangial conceptacle chamber diameter (300 μm in Spongites) and tetra/bisporangial conceptacle roof thickness (8 cells in Spongites). Two characters also distinguish Pneophyllum from Dawsoniolithon: tetra/bisporangial conceptacle roof thickness (8 cells in Dawsoniolithon) and thallus construction (dimerous in Pneophyllum vs. monomerous in Dawsoniolithon). This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

Biometria e armazenamento de sementes de genótipos de cacaueiro

Directory of Open Access Journals (Sweden)

Lucimara Ribeiro Venial

2017-03-01

Full Text Available Genótipos de Theobroma cacao L. devem ser melhor estudados, para se identificar aqueles que produzem sementes mais desenvolvidas e viáveis após o armazenamento. Objetivou-se com este trabalho estudar a biometria e dois tempos de armazenamento de sementes de genótipos de cacaueiro. A biometria foi avaliada em oito genótipos de cacaueiro (tratamentos. Foram instalados testes de germinação em delineamento inteiramente ao acaso, no esquema fatorial 8 x 2 (genótipos: CCN51, PH16, CEPEC2002, Ipiranga, SJ02, PS1319, TSH1188 e Comum x dois períodos de armazenamento: 0 e dois dias. O genótipo TSH1188 apresentou maior comprimento, relação comprimento/largura, espessura e massa de 100 sementes. A absorção de água das sementes recém-colhidas dos genótipos é lenta, justificada pelos altos teores de água, o que não caracteriza padrão-trifásico. Os teores de água reduziram em média 2,3 vezes nas sementes armazenadas em relação às recém-colhidas. A germinação das sementes recém-colhidas dos genótipos foi de 100%. Após o armazenamento, as sementes do PS1319 apresentaram a menor redução da germinação (39%, enquanto as dos PH16, CEPEC2002 e SJ02 reduziram 96%. A velocidade de germinação foi maior e o tempo médio menor que dois dias nas sementes recém-colhidas do PS1319, indicando serem mais tolerante à dessecação. Sugere-se o uso dos genótipos TSH1188 e PS1319 em programas de melhoramento genético.

Enfermedades genéticas más frecuentes en pacientes atendidos en consulta de genética clínica

Directory of Open Access Journals (Sweden)

Elibett Carcasés Carcasés

2015-02-01

Full Text Available La estimación de la prevalencia de las enfermedades genéticas se dificulta, entre otras causas, por su rareza. Se realizó un estudio descriptivo retrospectivo, para identificar las enfermedades genéticas de mayor prevalencia en pacientes atendidos por este programa en el Centro Provincial de Genética Médica de Las Tunas, Cuba; desde el año 1989 hasta julio de 2014. Se revisaron todas las historias clínicas. Predominó el origen monogénico (69 %, siendo los síndromes dismórficos los más numerosos y diversos, entre ellos los neurocutáneos, que representaron el 35 %. La enfermedad genética monogénica con mayor número de casos fue la Neurofibromatosis I con el 14,4 % y el 22,2 % de las enfermedades eran de origen monogénico y dismórfico. La Trisomía 21 representó el 77 % de la causa cromosómica. En el origen multifactorial prevalecieron los defectos congénitos mayores, entre ellos los defectos reductivos de miembros (27 %

Enhanced Control of Mercury and other HAPs by Innovative Modifications to Wet FGD Processes

International Nuclear Information System (INIS)

Hargrove, O.W.; Carey, T.R.; Richardson, C.F.; Skarupa, R.C.; Meserole, F.B.; Rhudy, R.G.; Brown, Thomas D.

1997-01-01

The overall objective of this project was to learn more about controlling emissions of hazardous air pollutants (HAPs) from coal-fired power plants that are equipped with wet flue gas desulfurization (FGD) systems. The project was included by FETC as a Phase I project in its Mega-PRDA program. Phase I of this project focused on three research areas. These areas in order of priority were: (1) Catalytic oxidation of vapor-phase elemental mercury; (2) Enhanced particulate-phase HAPs removal by electrostatic charging of liquid droplets; and (3) Enhanced mercury removal by addition of additives to FGD process liquor. Mercury can exist in two forms in utility flue gas--as elemental mercury and as oxidized mercury (predominant form believed to be HgCl 2 ). Previous test results have shown that wet scrubbers effectively remove the oxidized mercury from the gas but are ineffective in removing elemental mercury. Recent improvements in mercury speciation techniques confirm this finding. Catalytic oxidation of vapor-phase elemental mercury is of interest in cases where a wet scrubber exists or is planned for SO 2 control. If a loW--cost process could be developed to oxidize all of the elemental mercury in the flue gas, then the maximum achievable mercury removal across the existing or planned wet scrubber would increase. Other approaches for improving control of HAPs included a method for improving particulate removal across the FGD process and the use of additives to increase mercury solubility. This paper discusses results related only to catalytic oxidation of elemental mercury

From AWE-GEN to AWE-GEN-2d: a high spatial and temporal resolution weather generator

Science.gov (United States)

Peleg, Nadav; Fatichi, Simone; Paschalis, Athanasios; Molnar, Peter; Burlando, Paolo

2016-04-01

A new weather generator, AWE-GEN-2d (Advanced WEather GENerator for 2-Dimension grid) is developed following the philosophy of combining physical and stochastic approaches to simulate meteorological variables at high spatial and temporal resolution (e.g. 2 km x 2 km and 5 min for precipitation and cloud cover and 100 m x 100 m and 1 h for other variables variable (temperature, solar radiation, vapor pressure, atmospheric pressure and near-surface wind). The model is suitable to investigate the impacts of climate variability, temporal and spatial resolutions of forcing on hydrological, ecological, agricultural and geomorphological impacts studies. Using appropriate parameterization the model can be used in the context of climate change. Here we present the model technical structure of AWE-GEN-2d, which is a substantial evolution of four preceding models (i) the hourly-point scale Advanced WEather GENerator (AWE-GEN) presented by Fatichi et al. (2011, Adv. Water Resour.) (ii) the Space-Time Realizations of Areal Precipitation (STREAP) model introduced by Paschalis et al. (2013, Water Resour. Res.), (iii) the High-Resolution Synoptically conditioned Weather Generator developed by Peleg and Morin (2014, Water Resour. Res.), and (iv) the Wind-field Interpolation by Non Divergent Schemes presented by Burlando et al. (2007, Boundary-Layer Meteorol.). The AWE-GEN-2d is relatively parsimonious in terms of computational demand and allows generating many stochastic realizations of current and projected climates in an efficient way. An example of model application and testing is presented with reference to a case study in the Wallis region, a complex orography terrain in the Swiss Alps.

EPCGen2 Pseudorandom Number Generators: Analysis of J3Gen

Directory of Open Access Journals (Sweden)

Alberto Peinado

2014-04-01

Full Text Available This paper analyzes the cryptographic security of J3Gen, a promising pseudo random number generator for low-cost passive Radio Frequency Identification (RFID tags. Although J3Gen has been shown to fulfill the randomness criteria set by the EPCglobal Gen2 standard and is intended for security applications, we describe here two cryptanalytic attacks that question its security claims: (i a probabilistic attack based on solving linear equation systems; and (ii a deterministic attack based on the decimation of the output sequence. Numerical results, supported by simulations, show that for the specific recommended values of the configurable parameters, a low number of intercepted output bits are enough to break J3Gen. We then make some recommendations that address these issues.

Introducing AstroGen: The Astronomy Genealogy Project

OpenAIRE

Tenn, Joseph S.

2016-01-01

The Astronomy Genealogy Project ("AstroGen"), a project of the Historical Astronomy Division of the American Astronomical Society (AAS), will soon appear on the AAS website. Ultimately, it will list the world's astronomers with their highest degrees, theses for those who wrote them, academic advisors (supervisors), universities, and links to the astronomers or their obituaries, their theses when on-line, and more. At present the AstroGen team is working on those who earned doctorates with ast...

Genética humana e sociedade

OpenAIRE

Rosa, Vivian Leyser da

2000-01-01

Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências da Educação. Análise do campo de estudos sobre o entendimento público da ciência, distinguindo os modelos de deficit cognitivo e interativo, bem como suas implicações na esfera educacional. Estudo do panorama dos avanços atuais da genética humana, do ponto de vista científico, ético e social. Análise de aspectos relativos ao ensino de genética humana nos cursos de graduação da área da saúde, em nove Universidades...

Manipulación genética de seres humanos

OpenAIRE

Manuel Santos Alcántara

2006-01-01

El gran avance que ha tenido la Genética en los últimos años y, particularmente, aquello relacionado con el desciframiento del genoma humano, ha traído a la discusión pública la posibilidad concreta de manipular genéticamente a los seres humanos. El mejoramiento o perfeccionamiento genético de los seres humanos, denominado eugenesia, actualmente se ha convertido técnicamente en una realidad, motivando una profunda reflexión de tipo ético. La pregunta básica es la siguiente: aquello que es téc...

From the 'Village of a Thousand Souls' to 'Race Crossing in Jamaica': Arnold Gesell, eugenics and child development.

Science.gov (United States)

Weizmann, Fredric

2010-01-01

Perhaps best known for providing age-related norms in early development, norms that are still used as a basis for measures of developmental maturity, Arnold Gesell was a key figure in developmental psychology from the 1920s through the 1950s. After examining Gesell's reputation and status in the field, we explore Gesell's changing relationship to eugenics, both in terms of Gesell's often contradictory attitudes about the role of hereditary and environmental influences in development, and in terms of the broader relationship between the eugenics movement and science.

VOC and HAP recovery using ionic liquids

Energy Technology Data Exchange (ETDEWEB)

Michael R. Milota : Kaichang Li

2007-05-29

During the manufacture of wood composites, paper, and to a lesser extent, lumber, large amounts of volatile organic compounds (VOCs) such as terpenes, formaldehyde, and methanol are emitted to air. Some of these compounds are hazardous air pollutants (HAPs). The air pollutants produced in the forest products industry are difficult to manage because the concentrations are very low. Presently, regenerative thermal oxidizers (RTOs and RCOs) are commonly used for the destruction of VOCs and HAPs. RTOs consume large amounts of natural gas to heat air and moisture. The combustion of natural gas generates increased CO2 and NOx, which have negative implications for global warming and air quality. The aforementioned problems are addressed by an absorption system containing a room-temperature ionic liquid (RTIL) as an absorbent. RTILs are salts, but are in liquid states at room temperature. RTILs, an emerging technology, are receiving much attention as replacements for organic solvents in industrial processes with significant cost and environmental benefits. Some of these processes include organic synthesis, extraction, and metal deposition. RTILs would be excellent absorbents for exhausts from wood products facilities because of their unique properties: no measurable vapor pressure, high solubility of wide range of organic compounds, thermal stability to 200°C (almost 400°F), and immisciblity with water. Room temperature ionic liquids were tested as possible absorbents. Four were imidizolium-based and were eight phosphonium-based. The imidizolium-based ionic liquids proved to be unstable at the conditions tested and in the presence of water. The phosphonium-based ionic liquids were stable. Most were good absorbents; however, cleaning the contaminates from the ionic liquids was problematic. This was overcome with a higher temperature (120°C) than originally proposed and a very low pressure (1 kPa. Absorption trials were conducted with tetradecy

40 CFR 63.5749 - How do I calculate the organic HAP content of aluminum wipedown solvents?

Science.gov (United States)

2010-07-01

... Manufacturing Standards for Aluminum Recreational Boat Surface Coating Operations § 63.5749 How do I calculate... fraction of organic HAP in aluminum wipedown solvent j. m = number of different aluminum surface coatings...

Estudio molecular del gen MLL en 30 pacientes con leucemias agudas Molecular study of MLL gen in 30 patients with acute leukemias

Directory of Open Access Journals (Sweden)

Raquel Levón Herrera

2000-04-01

Full Text Available Los reordenamientos del gen MLL en la banda cromosómica 11q23 son frecuentes en leucemias agudas (LA en niños y en las LA secundarias desarrolladas después de la terapia con inhibidores de la enzima topoisomerasa II. En menor medida también se aprecia en adultos con LA. La presencia de estos reordenamientos se considera un indicador de mal pronóstico asociado con resultados clínicos desfavorables, por ello es muy importante realizar su determinación en las LA. En este trabajo mostramos los resultados preliminares de la introducción del estudio del gen MLL en nuestro país mediante la técnica de Southern. Analizamos ADN de 30 pacientes con LA, incluidos niños y adultos, que en el momento del estudio se encontraban al debut o en recaída. El estudio molecular se realizó con la sonda FA4, que es un inserto genómico del gen MLL. Sólo uno de los 30 pacientes mostró bandas de reordenamiento con 2 enzimas de restricción diferentes, el resto mostró el gen MLL en configuración germinal. Es interesante destacar que el paciente con el reordenamiento era un niño con leucemia mieloblástica aguda subtipo M5b, lo cual concuerda con la literatura, donde se describe que estos reordenamientos están estrechamente correlacionados con los subtipos mielomonocítico (M4 y monocítico (M5 de leucemia mieloide aguda (LMARearrangements of MLL gen in llq23 chromosomal band are frequents in childhood type of acute leukemia (AL and in secondary AL, developed after therapy with II topoisomerase enzyme. To a lesser extent also is seen in adults with AL. Presence of theses rearrangements is considered to be a worse prognosis indicator, associated with unfavourable clinical results, that is why it is very important to carry our its assessment in AL. In this paper authors present preliminary results from introduction of study on MLL gen in our country through Southern technique. DNA from 30 patients was analized, including children and adults, that at the

Targeting the Conserved Fusion Loop of HAP2 Inhibits the Transmission of Plasmodium berghei and falciparum

Directory of Open Access Journals (Sweden)

Fiona Angrisano

2017-12-01

Full Text Available Summary: Inhibiting transmission of Plasmodium is a central strategy in malarial eradication, and the biological process of gamete fusion during fertilization is a proven target for this approach. The lack of a structure or known molecular function of current anti-malarial vaccine targets has previously been a hindrance in the development of transmission-blocking vaccines. Structure/function studies have indicated that the conserved gamete membrane fusion protein HAP2 is a class II viral fusion protein. Here, we demonstrate that targeting a function-critical site of the fusion/cd loop with species-specific antibodies reduces Plasmodium berghei transmission in vivo by 58.9% and in vitro fertilization by up to 89.9%. A corresponding reduction in P. falciparum transmission (75.5%/36.4% reductions in intensity/prevalence is observed in complimentary field studies. These results emphasize conserved mechanisms of fusion in Apicomplexa, while highlighting an approach to design future anti-malarial transmission-blocking vaccines. : Angrisano et al. find that the HAP2 cd-loop can be targeted as an anti-malarial intervention, is immunogenic across multiple plasmodial species, can induce antibodies that specifically recognize the sexual stages of the parasitic life cycle, and can mediate transmission-blocking immunity in the lab and the field. Keywords: HAP2, malaria, transmission, fusion, vaccine

Bonding techniques for hybrid active pixel sensors (HAPS)

Energy Technology Data Exchange (ETDEWEB)

Bigas, M. [Centre Nacional de Microelectronica, CNM-IMB (CSIC), Campus Universitat Autonoma de Barcelona, 08193 Bellaterra, Barcelona (Spain)]. E-mail: Marc.Bigas@cnm.es; Cabruja, E. [Centre Nacional de Microelectronica, CNM-IMB (CSIC), Campus Universitat Autonoma de Barcelona, 08193 Bellaterra, Barcelona (Spain)]. E-mail: Enric.Cabruja@cnm.es; Lozano, M. [Centre Nacional de Microelectronica, CNM-IMB (CSIC), Campus Universitat Autonoma de Barcelona, 08193 Bellaterra, Barcelona (Spain)

2007-05-01

A hybrid active pixel sensor (HAPS) consists of an array of sensing elements which is connected to an electronic read-out unit. The most used way to connect these two different devices is bump bonding. This interconnection technique is very suitable for these systems because it allows a very fine pitch and a high number of I/Os. However, there are other interconnection techniques available such as direct bonding. This paper, as a continuation of a review [M. Lozano, E. Cabruja, A. Collado, J. Santander, M. Ullan, Nucl. Instr. and Meth. A 473 (1-2) (2001) 95-101] published in 2001, presents an update of the different advanced bonding techniques available for manufacturing a hybrid active pixel detector.

Ultra-fine structures of Pd-Ag-HAp nanoparticle deposition on protruded TiO2 barrier layer for dental implant

Science.gov (United States)

Jang, Jae-Myung; Kim, Seung-Dai; Park, Tae-Eon; Choe, Han-Cheol

2018-02-01

The biocompatibility structure of an implant surface is of great importance to the formation of new bone tissue around the dental implant and also has a significant chemical reaction in the osseointegration process. Thus, ultra-fine Pd-Ag-HAp nanoparticles have been electrodeposited on protruded TiO2 barrier layer in mixed electrolyte solutions. Unusual protrusions patterns, which are assigned to Pd-Ag-HAp nanoparticles, can be clearly differentiated from a TiO2 nanotube oxide layer formed by an anodizing process. In the chemical bonding state, the surface characteristics of Pd/Ag/HAp compounds have been investigated by FE-SEM, EDS mapping analysis, and XPS analysis. The mapping dots of the elements including Ti, Ca, Pd, Ag, and P showed a homogeneous distribution throughout the entire surface when deposited onto the protruded TiO2 barrier layer. The XPS spectra of Ti-2p, O-1S, Pd-3d, and Ag-3d have been investigated, with the major XPS peak indicating Pd-3d. The Ag-3d level was clearly observed with further scanning of the Ca-2p region. Based on the results of the chemical states, the structural properties of the protrusion patterns were also examined after being deposited onto the barrier oxide film, resulting in the representative protrusion patterns being mainly composed of Pd-Ag-HAp compounds. The results of the soaking evaluation showed that the protrusion patterns and the protruded TiO2 barrier layer were all effective in regards to biocompatibility.

Genética em transtornos alimentares: ampliando os horizontes de pesquisa

Directory of Open Access Journals (Sweden)

Pinheiro Andréa Poyastro

2006-01-01

Full Text Available OBJETIVO: Revisar a literatura atual concernente à pesquisa genética em transtornos do comportamento alimentar e discutir questões relevantes ao desenvolvimento de um projeto de pesquisa genética nessa área no Brasil. MÉTODO: A revisão realizada utilizou a base de dados Medline, no período de 1984 a maio de 2005, com os seguintes termos de busca: "anorexia nervosa", "bulimia nervosa", "eating disorders", "binge eating disorder", "family studies", "twin studies", "molecular genetics studies". RESULTADOS: Os dados atuais apontam para uma contribuição relevante dos fatores genéticos na suscetibilidade à anorexia e à bulimia nervosa. A pesquisa genética com populações miscigenadas deve levar em consideração o tamanho da amostra, a densidade de genotipagem e a estratificação populacional. Através de "admixture mapping" é possível estimar a estrutura genética destas populações e localizar genes relacionados à variação étnica de doenças ou traços de interesse. CONCLUSÕES: O desenvolvimento de uma grande iniciativa de colaboração em genética de transtornos alimentares no Brasil e na América Latina viabilizará estudar os fatores genéticos em transtornos do comportamento alimentar no contexto de grupos inter-étnicos, e integrar uma nova perspectiva biológica à etiologia destes distúrbios.

Resistência genética em genótipos de feijoeiro a Curtobacterium flaccumfaciens pv. flaccumfaciens Genetic resistance to Curtobacterium flaccumfaciens pv. flaccumfaciens in bean genotypes

Directory of Open Access Journals (Sweden)

Valmir Luiz de Souza

2006-09-01

Full Text Available Curtobacterium flaccumfaciens pv. flaccumfaciens (Cff agente causal da murcha-de-curtobacterium em feijoeiro (Phaseolus vulgaris, é um patógeno vascular de difícil controle. A doença foi detectada pela primeira vez no Brasil na safra das águas de 1995, no Estado de São Paulo. Por se tratar de uma doença de difícil controle, a resistência genética tem sido a melhor opção. O objetivo deste trabalho foi avaliar a reação de genótipos de feijoeiro à murcha-de-curtobacterium, frente a 333 acessos pertencentes ao banco de germoplasma de feijoeiro do Instituto Agronômico de Campinas (IAC. Oportunamente, foram selecionados genótipos de feijoeiro altamente resistentes e suscetíveis, com a finalidade de comparar a colonização de Cff no vaso do xilema a partir da visualização sob microscopia eletrônica de varredura. Os resultados da triagem da resistência genética em genótipos de feijoeiro indicaram a existência de variabilidade genética nas amostras dos 333 genótipos avaliados, ao isolado de Cff Feij 2634. Os materiais foram classificados em 4 grupos de resistência: 29 genótipos (8,7% comportaram-se como altamente resistentes, 13 genótipos (3,9% como resistentes, 18 genótipos (5% como moderadamente resistentes e 273 genótipos (81% suscetíveis. A partir dos resultados obtidos, cerca de 18% dos genótipos de feijoeiros, desde altamente resistentes à moderadamente resistentes, poderão ser úteis para o programa de melhoramento genético como fonte de genes para resistência a Cff. Através da microscopia eletrônica de varredura, foram observadas em genótipos altamente resistentes, várias aglutinações da bactéria envolvidas por filamentos e estruturas rendilhadas sob pontuações da parede do vaso do xilema, não verificados em genótipos suscetíveis, o que sugere a ativação de mecanismos de defesa estruturais e bioquímicos nas plantas resistentes.Curtobacterium flaccumfaciens pv. flaccumfaciens (Cff, the causal

Consideraciones genéticas sobre las dislipidemias y la aterosclerosis

OpenAIRE

Julio César Fernández Travieso

2008-01-01

La interacción entre factores genéticos y ambientales explican muchos aspectos de la aterosclerosis y las variaciones genéticas constituyen marcadores de riesgo de la enfermedad coronaria (EC), la cual ocupa el primer lugar entre las causas de morbilidad y mortalidad a nivel mundial. La predisposición familiar a padecer EC, junto al avance vertiginoso en técnicas de análisis de ADN y la disponibilidad de secuencias del genoma humano, han orientado la investigación de alteraciones genéticas re...

Divergencia genética en poblaciones peruanas detectada a partir de las frecuencias haplotípicas del mtDNA y del gen nuclear MBL

Directory of Open Access Journals (Sweden)

Jesús H. Córdova

2011-01-01

Full Text Available Objetivos: Avanzar en el conocimiento del origen de las poblaciones peruanas estudiadas en un contexto filogeográfico. Diseño: Estudio genético poblacional. Instituciones: Laboratorio de Genética Humana, Facultad de Ciencias Biológicas, Universidad Nacional Mayor de San Marcos, e Instituto de Genética y Biología Molecular, Facultad de Medicina, Universidad San Martín de Porras, Lima, Perú. Participantes: Siete poblaciones peruanas. Metodología: Análisis comparativo de los resultados a partir del estudio del mtDNA y el gen nuclear MBL de siete poblaciones peruanas, procesados de manera separada y luego combinados, utilizando el programa PHYLYP 3.65, para obtener valores FST de diferenciación genética y la construcción de árboles de distancias por aplicación del algorritmo UPGMA y el análisis subsecuente de los agrupamientos (clusters generados. Principales medidas de resultados: Árboles genéticos generados. Resultados: De manera separada, los árboles generados para cada marcador genético tuvieron topologías propias y diferentes entre sí. Procesados de manera combinada, el árbol resultante demostró que los mayores valores de diferenciación genética se hallaron en las Islas del Lago Titicaca (Puno, Perú conocidas -Taquile, Amantani y Anapia-, que fue calificada como muy alta, porque mostró valores de FST de 0.3113, 0.2949 y 0.3348 respecto de las poblaciones estudiadas, tanto fuera del Departamento de Puno -como Chachapoyas, Pucallpa y Chiclayo, respectivamente-, así como a la de los Uro del mismo Puno y del mismo Lago Titicaca (0.2837. Fuera de Puno, el par de poblaciones Chachapoyas-Pucallpa fue el menos divergente, al alcanzar entre ellas un valor de FST de 0.0108, calificándosele de pequeña. Conclusiones: El árbol obtenido del procesamiento de los marcadores vía una matriz combinada demostró que las poblaciones que habitan las islas de Taquile, Amantani y Anapia, divergen notablemente de las restantes cuatro

40 CFR 63.5758 - How do I determine the organic HAP content of materials?

Science.gov (United States)

2010-07-01

... operations and use that value as a substitute for mass fraction of organic HAP. (4) Alternative method. You... for each material used in your open molding resin and gel coat operations, carpet and fabric adhesive operations, or aluminum recreational boat surface coating operations, you must use one of the options in...

Towards an International Culture: Gen Y Students and SNS?

Science.gov (United States)

Lichy, Jessica

2012-01-01

This article reports the findings of a small-scale investigation into the Internet user behaviour of generation Y (Gen Y) students, with particular reference to social networking sites. The study adds to the literature on cross-cultural Internet user behaviour with specific reference to Gen Y and social networking. It compares how a cohort of…

Introducing AstroGen: the Astronomy Genealogy Project

Science.gov (United States)

Tenn, Joseph S.

2016-12-01

The Astronomy Genealogy Project (AstroGen), a project of the Historical Astronomy Division of the American Astronomical Society (AAS), will soon appear on the AAS website. Ultimately, it will list the world's astronomers with their highest degrees, theses for those who wrote them, academic advisors (supervisors), universities, and links to the astronomers or their obituaries, their theses when online, and more. At present the AstroGen team is working on those who earned doctorates with astronomy-related theses. We show what can be learned already, with just ten countries essentially completed.

An electronic flight bag for NextGen avionics

Science.gov (United States)

Zelazo, D. Eyton

2012-06-01

The introduction of the Next Generation Air Transportation System (NextGen) initiative by the Federal Aviation Administration (FAA) will impose new requirements for cockpit avionics. A similar program is also taking place in Europe by the European Organisation for the Safety of Air Navigation (Eurocontrol) called the Single European Sky Air Traffic Management Research (SESAR) initiative. NextGen will require aircraft to utilize Automatic Dependent Surveillance-Broadcast (ADS-B) in/out technology, requiring substantial changes to existing cockpit display systems. There are two ways that aircraft operators can upgrade their aircraft in order to utilize ADS-B technology. The first is to replace existing primary flight displays with new displays that are ADS-B compatible. The second, less costly approach is to install an advanced Class 3 Electronic Flight Bag (EFB) system. The installation of Class 3 EFBs in the cockpit will allow aircraft operators to utilize ADS-B technology in a lesser amount of time with a decreased cost of implementation and will provide additional benefits to the operator. This paper describes a Class 3 EFB, the NexisTM Flight-Intelligence System, which has been designed to allow users a direct interface with NextGen avionics sensors while additionally providing the pilot with all the necessary information to meet NextGen requirements.

Espasmo hemifacial e impressão basilar associados a malformação de arnold-chiari relato de caso

Directory of Open Access Journals (Sweden)

Manoel Baldoino Leal Filho

1992-09-01

Full Text Available Os autores relatam o caso de uma paciente com espasmo hemifacial e impressão basilar associados a malformação de Arnold-Chiari. Com a descompressão cirúrgica da fossa posterior, empregada no tratamento da impressão basilar, houve melhora do quadro clínico e o espasmo hemifacial se reduziu quanto à frequência, duração e intensidade. É enfatizada a necessidade do tratamento etiológico do espasmo hemifacial, antes de se recorrer à toxina botulínica.

Conceptos básicos de programación genética

Directory of Open Access Journals (Sweden)

José Jesús Martínez Páez

2001-04-01

Full Text Available La Programación Genética, PG, es un retoño de los Algoritmos Genéticos, en la cual los cromosomas que sufren la adaptación son en sí mismos programas de computador. Se usan operadores genéticos  especializados que generalizan la recombinación sexual y la mutación, para los programas de computador estructurados en árbol que están bajo adaptación.

SNPexp - A web tool for calculating and visualizing correlation between HapMap genotypes and gene expression levels

Directory of Open Access Journals (Sweden)

Franke Andre

2010-12-01

Full Text Available Abstract Background Expression levels for 47294 transcripts in lymphoblastoid cell lines from all 270 HapMap phase II individuals, and genotypes (both HapMap phase II and III of 3.96 million single nucleotide polymorphisms (SNPs in the same individuals are publicly available. We aimed to generate a user-friendly web based tool for visualization of the correlation between SNP genotypes within a specified genomic region and a gene of interest, which is also well-known as an expression quantitative trait locus (eQTL analysis. Results SNPexp is implemented as a server-side script, and publicly available on this website: http://tinyurl.com/snpexp. Correlation between genotype and transcript expression levels are calculated by performing linear regression and the Wald test as implemented in PLINK and visualized using the UCSC Genome Browser. Validation of SNPexp using previously published eQTLs yielded comparable results. Conclusions SNPexp provides a convenient and platform-independent way to calculate and visualize the correlation between HapMap genotypes within a specified genetic region anywhere in the genome and gene expression levels. This allows for investigation of both cis and trans effects. The web interface and utilization of publicly available and widely used software resources makes it an attractive supplement to more advanced bioinformatic tools. For the advanced user the program can be used on a local computer on custom datasets.

Co-ordinate control of synthesis of mitochondrial and non-mitochondrial hemoproteins: a binding site for the HAP1 (CYP1) protein in the UAS region of the yeast catalase T gene (CTT1).

Science.gov (United States)

Winkler, H; Adam, G; Mattes, E; Schanz, M; Hartig, A; Ruis, H

1988-01-01

Control of expression of the Saccharomyces cerevisiae CTT1 (catalase T) gene by the HAP1 (CYP1) gene, a mediator of heme control of mitochondrial cytochromes, was studied. Expression of a CTT1-lacZ fusion in a hap1 mutant showed that the CTT1 promoter is under HAP1 control. As demonstrated by a gel retardation assay, the HAP1 protein binds to a heme control region of the CTT1 gene. This binding in vitro is stimulated by hemin. The HAP1-binding sequence was localized by using DNA fragments spanning different regions, by DNase I footprinting and by methylation interference of DNA-protein binding. The binding site was compared to the HAP1-binding sequences previously characterized in detail (UAS1CYC1, UASCYC7). There is strikingly little similarity between the three sequences, which have only four of those 23 bp in common which are protected from DNase I digestion. However, the pattern of major and minor groove contacts in the complex is quite similar in all three cases. The results obtained show that there is true co-ordinate control of expression of mitochondrial cytochromes and at least some extra-mitochondrial hemoproteins. Heme acts as a metabolic signal in this coordination, which is mediated by the HAP1 protein. Images PMID:2844525

CLONACIÓN Y FILOGENIA MOLECULAR DE UN SEGMENTO DEL GEN CODANTE DE LA ACTINA DE MYRCIARIA DUBIA “CAMU-CAMU”: UN CANDIDATO PARA GEN DE REFERENCIA

Directory of Open Access Journals (Sweden)

Juan Carlos Castro Gómez

2012-12-01

Full Text Available Myrciaria dubia “camu-camu” es un frutal amazónico caracterizado por su amplia variación de vitamina C. Pero los estudios genético moleculares que puedan explicar esta variación son limitados. Por ello nuestro objetivo fue realizar la clonación y filogenia molecular de un segmento del gen codante de la actina de M. dubia. Las muestras fueron obtenidas de la colección de germoplasma del INIA. Luego, el ARN fue purificado y mediante RT-PCR con cebadores degenerados se amplificó un segmento del gen. En base a la secuencia obtenida se diseñaron cebadores específicos para PCR en tiempo real. Los resultados muestran que se ha aislado, clonado y secuenciado un segmento del gen codante de actina de M. dubia y detectado su expresión en hojas, pulpa y cáscara de M. dubia. Así, con el soporte de herramientas bioinformáticas y uso de técnicas de biología molecular hemos aislado, clonado y secuenciado un segmento del gen codante de la actina de M. dubia. Asimismo, los análisis realizados muestran que el gen se expresa y presenta niveles similares de expresión en hojas, pulpa y cáscara de M. dubia. Sin embargo, es necesario realizar más experimentos a fin de verificar su estabilidad de expresión.

Action Movie in Election Day: Eraser (1996, Arnold Chwarzenegger and Other Politics Medias

Directory of Open Access Journals (Sweden)

Fabro Boaz Steibel

2008-08-01

Full Text Available This article aims to explore methodological frontiers between movie theory and political ommunication studies. When identifying traces of how politics, art and entertainment interact, it is possible to understand how movie celebrities can act as politicians, and vice versa. Arnold Schwarzenegger is a world famous actor who has twice won the Californian gubernatorial election. The principal purpose of this article is not to discuss political spectacle or analyse Schwarzenegger’s approach to government. The idea is to understand how a film in which Schwarzenegger starred over a decade ago (Eraser, 1996 has influenced his campaign image construction. The article’s methodological basis is a collective text by the Editors of Cahiers du Cinéma, based on John Ford’s Young Mr. Lincoln (1939. Its methodology allows us to observe important characteristics of Schwarzenegger’s role in the Eraser movie, which are then compared to the 2002 election scenario.

Pühapäeva hommik : [luuletused] / Wallace Stevens ; tõlk. Hasso Krull, Märt Väljataga

Index Scriptorium Estoniae

Stevens, Wallace

2008-01-01

Sisu: Pühapäeva hommik ; Peter Quince klahvide ees ; Mozart, 1935 ; Postkaart vulkaanist ; Moodsast luulest ; Paks punane mees loeb ette ; Seesmise armukese viimane üksikõne ; Ühe üksikasja kulg. Elu- ja loomeloolisi andmeid autori kohta lk. 531-532

Safety Design Criteria (SDC) for Gen-IV Sodium-cooled Fast Reactor

International Nuclear Information System (INIS)

Nakai, Ryodai

2013-01-01

SDC Development Background & Objectives: • Safety Design Criteria (SDC) Development for Gen-IV SFR: – Proposed at the GIF Policy Group (PG) meeting in October 2010 –SDC “harmonization” is increasingly important for: • Realization of enhanced safety designs meeting to Gen-IV safety goals and safety approach common to SFR systems; • Preparation for the forthcoming licensing in the near future; • Because Gen-IV SFR are progressing into conceptual design stage. • The SDC is the Reference criteria: – Of the designs of safety-related Structures, Systems & Components that are specific to the SFR system; – For clarifying the requisites systematically & comprehensively; – When the technology developers apply the basic safety approach and use the codes & standards for conceptual design of the Gen-IV SFR system

Aproximación genómica al diagnóstico genético de las distrofias hereditarias de retina y búsqueda de nuevos genes relacionados

OpenAIRE

González del Pozo, María

2014-01-01

Diagnosticar genéticamente a las familias afectas de alguna de las distrofias hereditarias de retina (DHR) es, desde el punto de vista del genetista, una tarea ardua y complicada, si atendemos a la gran cantidad de genes y mutaciones reportados hasta la fecha. La gran heterogeneidad clínica y genética que caracteriza a este conjunto de enfermedades, es sin duda el mayor impedimento para su resolución genética. En este escenario, el empleo de herramientas cada vez más poderosas es indispensabl...

Genética e hanseníase

OpenAIRE

Beiguelman Bernardo

2002-01-01

As diferentes linhas de pesquisa utilizadas para investigar a importância dos fatores hereditários humanos na determinação da resistência/suscetibilidade à infecção pelo Mycobacterium leprae foram discutidas no presente trabalho. Uma síntese dessas abordagens permitiu analisar os resultados das investigações sobre associação da hanseníase com polimorfismos genéticos, distribuição familial da hanseníase, prevalência da hanseníase e distância genética, concordância da hanseníase em gêmeos e est...

Arnold Sommerfeld. Atomic physicist and messenger of culture 1868-1951. A biography

International Nuclear Information System (INIS)

Eckert, Michael

2013-01-01

Arnold Sommerfeld is beside Albert Einstein, Niels Bohr, and Max Planck one of the founders of modern atomic and quantum theory. His career began in the 1890th years at the University of Goettingen, the world center of mathematics of that time. Since 1906 he created on the professorship for theoretical physics at the Munich university one of the most important schools of science, the students of which are well-known theorists of the atomic era like as the Nobel-price winners Hans Bethe, Peter Debye, Wolfgang Pauli, and Werner Heisenberg. He also developed far beyond his subject an unprecedented impact. He travelled as ''messenger of culture'' in many countries in order to advertise in the years after the first world war for the reputation of Germany as culture nation. By the nationalsocialism the Munich ''nursery of theoretical physics'' however was prepared an inglorious end, because Sommerfeld counted for a ''main propagandist of Jewish theories''. By the example of this life of a physicist also the eventful history of a whole subject.

Geography of resonances and Arnold diffusion in a priori unstable Hamiltonian systems

International Nuclear Information System (INIS)

Delshams, Amadeu; Huguet, Gemma

2009-01-01

In this paper we consider the case of a general C r+2 perturbation, for r large enough, of an a priori unstable Hamiltonian system of 2 + 1/2 degrees of freedom, and we provide explicit conditions on it, which turn out to be C 2 generic and are verifiable in concrete examples, which guarantee the existence of Arnold diffusion. This is a generalization of the result in Delshams et al (2006 Mem. Am. Math. Soc.) where the case of a perturbation with a finite number of harmonics in the angular variables was considered. The method of proof is based on a careful analysis of the geography of resonances created by a generic perturbation and it contains a deep quantitative description of the invariant objects generated by the resonances therein. The scattering map is used as an essential tool to construct transition chains of objects of different topology. The combination of quantitative expressions for both the geography of resonances and the scattering map provides, in a natural way, explicit computable conditions for instability

Analisis Mutasi Gen Protein X Virus Hbv Pada Penderita Hepatitis B Akut Di Manado

OpenAIRE

Fatimawali; Kepel, Billy

2014-01-01

Faktor-faktor yang mempengaruhi perkembangan hepatitis B kronis menjadi kanker hati antara lain mutasi pada gen x. Penelitian ini bertujuan untuk mengidentifikasi gen protein x virus HBV dan menganalisis apakah terjadi mutasi gen yang terkait dengan munculnya tumor ganas sirosis hati (HCC). Penelitian ini menggunakan primer untuk proses nested PCR yang telah dirancang sebelumnya. Proses nested PCR terhadap 10 sampel DNA HBV pasien dilakukan untuk mengamplifikasi fragmen DNA gen x dilanjutkan ...

40 CFR Appendix - Alternative Organic HAP Emissions Limits for Open Molding, Centrifugal Casting, and SMC...

Science.gov (United States)

2010-07-01

... Limits for Open Molding, Centrifugal Casting, and SMC Manufacturing Operations Where the Standards Are..., Table 5 Alternative Organic HAP Emissions Limits for Open Molding, Centrifugal Casting, and SMC... casting—CR/HS 3,4 A vent system that moves heated air through the mold 27 lb/ton. 8. Centrifugal casting...

GLIDERS - A web-based search engine for genome-wide linkage disequilibrium between HapMap SNPs

Directory of Open Access Journals (Sweden)

Broxholme John

2009-10-01

Full Text Available Abstract Background A number of tools for the examination of linkage disequilibrium (LD patterns between nearby alleles exist, but none are available for quickly and easily investigating LD at longer ranges (>500 kb. We have developed a web-based query tool (GLIDERS: Genome-wide LInkage DisEquilibrium Repository and Search engine that enables the retrieval of pairwise associations with r2 ≥ 0.3 across the human genome for any SNP genotyped within HapMap phase 2 and 3, regardless of distance between the markers. Description GLIDERS is an easy to use web tool that only requires the user to enter rs numbers of SNPs they want to retrieve genome-wide LD for (both nearby and long-range. The intuitive web interface handles both manual entry of SNP IDs as well as allowing users to upload files of SNP IDs. The user can limit the resulting inter SNP associations with easy to use menu options. These include MAF limit (5-45%, distance limits between SNPs (minimum and maximum, r2 (0.3 to 1, HapMap population sample (CEU, YRI and JPT+CHB combined and HapMap build/release. All resulting genome-wide inter-SNP associations are displayed on a single output page, which has a link to a downloadable tab delimited text file. Conclusion GLIDERS is a quick and easy way to retrieve genome-wide inter-SNP associations and to explore LD patterns for any number of SNPs of interest. GLIDERS can be useful in identifying SNPs with long-range LD. This can highlight mis-mapping or other potential association signal localisation problems.

Craniostenose em gêmeos: estudo genético

Directory of Open Access Journals (Sweden)

Walter Carlos Pereira

1968-09-01

Full Text Available É relatada a ocorrência de formas clínicas diversas de craniostenose em gêmeos de sexo diferente. A menina apresentava obliteração completa da sutura coronaria e dos dois terços anteriores da sutura sagital; no menino a sutura sagital era a única afetada. O estudo genético mostrou que a craniostenose independe de aberrações cromossômicas, indicando ser transmitida por gens recessivos raros de natureza autossômica.

In vitro study of 3D PLGA/n-HAp/β-TCP composite scaffolds with etched oxygen plasma surface modification in bone tissue engineering

Energy Technology Data Exchange (ETDEWEB)

Roh, Hee-Sang [Department of Dental Materials, School of Dentistry, Chosun University, 309 Pilmun-daero, Dong-gu, Gwangju 61452 (Korea, Republic of); Jung, Sang-Chul [Department of Environmental Engineering, Sunchon National University, 255 Jungang-ro, Sunchon 57922 (Korea, Republic of); Kook, Min-Suk [Department of Oral and Maxillofacial Surgery, School of Dentistry, Chonnam National University, 77 Yongbong-ro, Buk-gu, Gwangju 61186 (Korea, Republic of); Kim, Byung-Hoon, E-mail: kim5055@chosun.ac.kr [Department of Dental Materials, School of Dentistry, Chosun University, 309 Pilmun-daero, Dong-gu, Gwangju 61452 (Korea, Republic of)

2016-12-01

Highlights: • PLGA and PLGA/n-HAp/β-TCP scaffolds were successfully fabricated by 3D printing. • Oxygen plasma etching increases the wettability and surface roughness. • Bioceramics and oxygen plasma etching and could be used to improve the cell affinity. - Abstract: Three-dimensional (3D) scaffolds have many advantageous properties for bone tissue engineering application, due to its controllable properties such as pore size, structural shape and interconnectivity. In this study, effects on oxygen plasma surface modification and adding of nano-hydroxyapatite (n-HAp) and β-tricalcium phosphate (β-TCP) on the 3D PLGA/n-HAp/β-TCP scaffolds for improving preosteoblast cell (MC3T3-E1) adhesion, proliferation and differentiation were investigated. The 3D PLGA/n-HAp/β-TCP scaffolds were fabricated by 3D Bio-Extruder equipment. The 3D scaffolds were prepared with 0°/90° architecture and pore size of approximately 300 μm. In addition 3D scaffolds surface were etched by oxygen plasma to enhance the hydrophilic property and surface roughness. After oxygen plasma treatment, the surface chemistry and morphology were investigated by Fourier transform infrared spectroscopy, scanning electron microscopy, and atomic force microscopy. And also hydrophilic property was measured by contact angle. The MC3T3-E1 cell proliferation and differentiation were investigated by MTT assay and ALP activity. In present work, the 3D PLGA/HAp/beta-TCP composite scaffold with suitable structure for the growth of osteoblast cells was successfully fabricated by 3D rapid prototyping technique. The surface hydrophilicity and roughness of 3D scaffold increased by oxygen plasma treatment had a positive effect on cell adhesion, proliferation, and differentiation. Furthermore, the differentiation of MC3T3-E1 cell was significantly enhanced by adding of n-HAp and β-TCP on 3D PLGA scaffold. As a result, combination of bioceramics and oxygen plasma treatment showed a synergistic effect on

Overexpression and Purification of C-terminal Fragment of the Passenger Domain of Hap Protein from Nontypeable Haemophilus influenzae in a Highly Optimized Escherichia coli Expression System

Science.gov (United States)

Tabatabaee, Akram; Siadat, Seyed Davar; Moosavi, Seyed Fazllolah; Aghasadeghi, Mohammad Reza; Memarnejadian, Arash; Pouriayevali, Mohammad Hassan; Yavari, Neda

2013-01-01

Background Nontypeable Haemophilus influenzae (NTHi) is a common cause of respiratory tract disease and initiates infection by colonization in nasopharynx. The Haemophilus influenzae (H. influenzae) Hap adhesin is an auto transporter protein that promotes initial interaction with human epithelial cells. Hap protein contains a 110 kDa internal passenger domain called “HapS” and a 45 kDa C-terminal translocator domain called “Hapβ”. Hap adhesive activity has been recently reported to be connected to its Cell Binding Domain (CBD) which resides within the 311 C-terminal residues of the internal passenger domain of the protein. Furthermore, immunization with this CBD protein has been shown to prevent bacterial nasopharynx colonization in animal models. Methods To provide enough amounts of pure HapS protein for vaccine studies, we sought to develop a highly optimized system to overexpress and purify the protein in large quantities. To this end, pET24a-cbd plasmid harboring cbd sequence from NTHi ATCC49766 was constructed and its expression was optimized by testing various expression parameters such as growth media, induction temperature, IPTG inducer concentration, induction stage and duration. SDS-PAGE and Western-blotting were used for protein analysis and confirmation and eventually the expressed protein was easily purified via immobilized metal affinity chromatography (IMAC) using Ni-NTA columns. Results The highest expression level of target protein was achieved when CBD expressing E. coli BL21 (DE3) cells were grown at 37°C in 2xTY medium with 1.0 mM IPTG at mid-log phase (OD600 nm equal to 0.6) for 5 hrs. Amino acid sequence alignment of expressed CBD protein with 3 previously published CBD amino acid sequences were more than %97 identical and antigenicity plot analysis further revealed 9 antigenic domains which appeared to be well conserved among different analyzed CBD sequences. Conclusion Due to the presence of high similarity among CBD from NTHi ATCC

A Virtual Reality Framework to Optimize Design, Operation and Refueling of GEN-IV Reactors

International Nuclear Information System (INIS)

Rizwan-uddin; Nick Karancevic; Stefano Markidis; Joel Dixon; Cheng Luo; Jared Reynolds

2008-01-01

Many GEN-IV candidate designs are currently under investigation. Technical issues related to material, safety and economics are being addressed at research laboratories, industry and in academia. After safety, economic feasibility is likely to be the most important criterion in the success of GEN-IV design(s). Lessons learned from the designers and operators of GEN-II (and GEN-III) reactors must play a vital role in achieving both safety and economic feasibility goals

A Virtual Reality Framework to Optimize Design, Operation and Refueling of GEN-IV Reactors.

Energy Technology Data Exchange (ETDEWEB)

Rizwan-uddin; Nick Karancevic; Stefano Markidis; Joel Dixon; Cheng Luo; Jared Reynolds

2008-04-23

many GEN-IV candidate designs are currently under investigation. Technical issues related to material, safety and economics are being addressed at research laboratories, industry and in academia. After safety, economic feasibility is likely to be the most important crterion in the success of GEN-IV design(s). Lessons learned from the designers and operators of GEN-II (and GEN-III) reactors must play a vital role in achieving both safety and economic feasibility goals.

Transformação genética em espécies florestais.

OpenAIRE

Claudia Studart-Guimarães; Cristiano Lacorte; Ana Cristina Miranda Brasileiro

2010-01-01

A transformação genética, que compreende a introdução de genes exógenos de forma controlada no genoma de uma célula vegetal e posterior regeneração da planta transgênica, tem contribuído com os programas de melhoramento genético de plantas pela obtenção de genótipos com novas características de interesse. O melhoramento de espécies florestais é limitado por características intrínsecas a tais espécies, como a altura dos indivíduos e o ciclo longo de vida. A transformação genética constitui, po...

Preserving Accuracy in GenBank

DEFF Research Database (Denmark)

Bidartondo, M.I.; Bruns, T. D.; Blackwell, M.

2008-01-01

GenBank, the public repository for nucleotide and protein sequences, is a critical resource for molecular biology, evolutionary biology, and ecology. While some attention has been drawn to sequence errors (1), common annotation errors also reduce the value of this database. In fact, for organisms...

GenMAPP 2: new features and resources for pathway analysis

Directory of Open Access Journals (Sweden)

Dahlquist Kam D

2007-06-01

Full Text Available Abstract Background Microarray technologies have evolved rapidly, enabling biologists to quantify genome-wide levels of gene expression, alternative splicing, and sequence variations for a variety of species. Analyzing and displaying these data present a significant challenge. Pathway-based approaches for analyzing microarray data have proven useful for presenting data and for generating testable hypotheses. Results To address the growing needs of the microarray community we have released version 2 of Gene Map Annotator and Pathway Profiler (GenMAPP, a new GenMAPP database schema, and integrated resources for pathway analysis. We have redesigned the GenMAPP database to support multiple gene annotations and species as well as custom species database creation for a potentially unlimited number of species. We have expanded our pathway resources by utilizing homology information to translate pathway content between species and extending existing pathways with data derived from conserved protein interactions and coexpression. We have implemented a new mode of data visualization to support analysis of complex data, including time-course, single nucleotide polymorphism (SNP, and splicing. GenMAPP version 2 also offers innovative ways to display and share data by incorporating HTML export of analyses for entire sets of pathways as organized web pages. Conclusion GenMAPP version 2 provides a means to rapidly interrogate complex experimental data for pathway-level changes in a diverse range of organisms.

Update History of This Database - GenLibi | LSDB Archive [Life Science Database Archive metadata

Lifescience Database Archive (English)

Full Text Available switchLanguage; BLAST Search Image Search Home About Archive Update History Data ...List Contact us GenLibi Update History of This Database Date Update contents 2014/03/25 GenLibi English archi...base Description Download License Update History of This Database Site Policy | Contact Us Update History of This Database - GenLibi | LSDB Archive ... ...ve site is opened. 2007/03/01 GenLibi ( http://gene.biosciencedbc.jp/ ) is opened. About This Database Data

Sistema inmune y genética: un abordaje diferente a la diversidad de anticuerpos.

OpenAIRE

Matta Camacho, Nubia Estela

2011-01-01

RESUMEN Es común encontrar en los libros de inmunología o de genética un capítulo con el título de “sistema inmune y genética”, sin embargo su asociación se centra en cómo la generación de anticuerpos rompió el paradigma “un gen, una proteína”, pues en el caso de la producción de anticuerpos, un gen produce millones de proteínas. El sistema inmune tiene muchos vínculos con la genética y la herencia; esta asociación se da porque cualquier sustancia o compuesto que produzca un organi...

HOT SPOT RELIEF WITH EMBEDDED BEAM FOR CDMA SYSTEMS IN HAPS

Institute of Scientific and Technical Information of China (English)

无

2006-01-01

This paper proposes a novel micro/macro beam coverage scheme used in High Altitude Platform System (HAPS) Code Division Multiple Access (CDMA) systems. A relief of traffic burden in hot spot areas is achieved by embedding micro-beams into the macro-beams at the hot spot locations, together with appropriate power ratio control and user ratio control. The simulation results show that the hot spot problem can be relieved efficiently with the presented configuration, and a higher and more stable system capacity is expectable despite the variation of user distribution.

Perda auditiva genética Genetic hearing loss

Directory of Open Access Journals (Sweden)

Ricardo Godinho

2003-01-01

Full Text Available O progresso das pesquisas relacionadas à perda auditiva genética tem provocado um importante avanço do entendimento dos mecanismos moleculares que governam o desenvolvimento, a função, a resposta ao trauma e o envelhecimento do ouvido interno. Em países desenvolvidos, mais de 50% dos casos de surdez na infância é causada por alterações genéticas e as perdas auditivas relacionadas à idade têm sido associadas com mecanismos genéticos. OBJETIVO: O objetivo desta revisão é relatar as informações mais recentes relacionadas às perdas audtivas de origem genética. FORAMA DE ESTUDO: Revisão sistemática. MATERIAL E MÉTODO: A revisão da literatura inclui artigos indexados à MEDLINE (Biblioteca Nacional de Saúde, NIH-USA e publicados nos últimos 3 anos, além das informações disponíveis na Hereditary Hearing Loss Home Page. CONCLUSÃO: Os recentes avanços no entendimento das perdas auditivas de origem genética têm favorecido a nossa compreensão da função auditiva e tornado o diagnóstico mais apurado. Possivelmente, no futuro, este conhecimento também proporcionará o desenvolvimento de novas terapias para o tratamento das causas genéticas das perdas auditivas.The progress in the research of genetic hearing loss has advanced our understanding of the molecular mechanisms that govern inner ear development, function and response to injury and aging. In the developed world, over 50% of childhood deafness is attributable to genetic causes and even age-related hearing loss has been associated with genetic mechanisms. AIM: The objective of this review is to summarize recent knowledge in genetic hearing loss. STUDY DESIGN: Sistematic review. MATERIAL AND METHODS: The literature review included articles indexed at MEDLINE (The National Library of Medicine, The National Institute of Health - USA focusing on publications from the past 3 years plus the information available at the Hereditary Hearing Loss Home Page. CONCLUSION

KARAKTERISTIK SEKUEN cDNA PENGKODE GEN ANTI VIRUS DARI UDANG WINDU, Penaeus monodon

Directory of Open Access Journals (Sweden)

Andi Parenrengi

2016-11-01

Full Text Available Transgenesis pada ikan merupakan sebuah teknik modern yang berpotensi besar dalam menghasilkan organisme yang memiliki karakter lebih baik melalui rekombinan DNA gen target termasuk gen anti virus dalam peningkatan resistensi pada udang. Gen anti virus PmAV (Penaeus monodon Anti Viral gene merupakan salah satu gen pengkode anti virus yang berasal dari spesies krustase. Penelitian ini dilakukan untuk mengetahui karakteristik gen anti virus yang diisolasi dari udang windu, Penaeus monodon. Isolasi gen anti virus menggunakan metode Polymerase Chain Reaction (PCR dan selanjutnya dipurifikasi untuk sekuensing. Data yang dihasilkan dianalisis dengan program Genetyx Versi 7 dan basic local alignment search tool (BLAST. Hasil penelitian menunjukkan bahwa gen anti virus PmAV yang berhasil diisolasi dari cDNA udang windu dengan panjang sekuen 520 bp yang mengkodekan 170 asam amino. BLAST-N menunjukkan tingkat similaritas yang sangat tinggi (100% dengan gen anti virus yang ada di GeneBank. Komposisi asam amino penyusun gen anti virus yang paling besar adalah serin (10,00%, sedangkan yang terkecil adalah asam amino prolin dan lisin masing-masing 1,76%. Analisis sekuen gen dan deduksi asam amino (BLAST-P memperlihatkan adanya C-type lectin-like domain (CTLD yang memiliki kemiripan dengan gen C-type lectin yang diisolasi dari beberapa spesies krustase. Transgenic fish technology is a potential modern technique in producing better character organism through DNA recombinant of target genes including anti viral gene for improvement of shrimp immunity. PmAV (Penaeus monodon Anti Viral gene is one of anti viral genes isolated from crustacean species. The research was conducted to analyze the characteristics anti viral gene isolated from tiger prawn, Penaeus monodon. Anti viral gene was isolated using Polymerase Chain Reaction (PCR technique and then purified for sequencing. Data obtained were analyzed using Genetyx Version 7 software and basic local alignment

Algoritmos genéticos

Directory of Open Access Journals (Sweden)

José Jesús Martínez Páez

1998-10-01

Full Text Available Esta técnica se basa en el concepto de evolución a través de selección de los mejores individuos, y de los operadores genéticos de selección, reproducción y mutación. Se trata entonces, de definir un espacio de soluciones para el problema que se quiere solucionar, en una cadena de bits. A esto se le conoce como la codificación del cromosoma, donde cada bit, denominado gen  tiene cierto significado especial. Inicialmente el algoritmo genera al azar muchas de estas cadenas o seres, es decir, una población, que luego confronta can un ambiente, que es el problema solucionar o función que se quiere optimizar. De esta confrontación  o evaluación a que se somete cada ser. Se obtiene información sobre cómo se comporto cada uno. A través de métodos aleatorios, pero con probabilidad de selección proporcional a su comportamiento, es decir, a mejor comportamiento mayor probabilidad, se selecciona una nueva población de seres supuestamente mejores que la generación anterior.

Ekspresi Gen CYP19 Aromatase, Estrogen, Androgen pada penderita Periodontitis Agresif

Directory of Open Access Journals (Sweden)

Dahlia Herawati

2016-11-01

Full Text Available Kepadatan tulang tubuh ditentukan oleh gen CYP19 aromatase, hormon estrogen dan androgen. Pada periodontitis agresif terjadi perkembangan cepat kerusakan tulang alveolar, dan kerusakan tulang alveoler tersebut tidak diimbangioleh regenerasi tulang. Tujuan penelitian ini adalah menunjukkan ekspresi gen CYP19 aromatase, estrogen, androgen pada penderita periodontitis agresif agar dapat untuk menjadi pertimbangan pada saat melakukan perawatan periodontal. Metode penelitian, pemeriksaan ekspresi gen aromatse CYP19 berasal dari spesimen tulang alveolar menggunakan imunohistokimia, pengukuran hormon estrogen dan androgen dari serum menggunakan Vidas: Elfa. Hasil penelitian ekspresi gene CYP19 aromatase pada periodontitis agresif menunjukkan gambaran lebih rendah densitasnya dibandingkan pada nonperiodontitis. Estrogen dan androgen pad aperiodontitis agresif ada kecenderungan lebih rendah dibandingkan pada nonperiodontitis. Kesimpulan regenerasi tulang alveoler pad a periodontitis agresif terhambat karena sedikitnya gen CYP19 aromatase dan hormon estrogen dan androgen yang berperan pada pembentukan tulang alveoler kurang memadai.

Unexpected Relationships and Inbreeding in HapMap Phase III Populations

Science.gov (United States)

Stevens, Eric L.; Baugher, Joseph D.; Shirley, Matthew D.; Frelin, Laurence P.; Pevsner, Jonathan

2012-01-01

Correct annotation of the genetic relationships between samples is essential for population genomic studies, which could be biased by errors or omissions. To this end, we used identity-by-state (IBS) and identity-by-descent (IBD) methods to assess genetic relatedness of individuals within HapMap phase III data. We analyzed data from 1,397 individuals across 11 ethnic populations. Our results support previous studies (Pemberton et al., 2010; Kyriazopoulou-Panagiotopoulou et al., 2011) assessing unknown relatedness present within this population. Additionally, we present evidence for 1,657 novel pairwise relationships across 9 populations. Surprisingly, significant Cotterman's coefficients of relatedness K1 (IBD1) values were detected between pairs of known parents. Furthermore, significant K2 (IBD2) values were detected in 32 previously annotated parent-child relationships. Consistent with a hypothesis of inbreeding, regions of homozygosity (ROH) were identified in the offspring of related parents, of which a subset overlapped those reported in previous studies (Gibson et al. 2010; Johnson et al. 2011). In total, we inferred 28 inbred individuals with ROH that overlapped areas of relatedness between the parents and/or IBD2 sharing at a different genomic locus between a child and a parent. Finally, 8 previously annotated parent-child relationships had unexpected K0 (IBD0) values (resulting from a chromosomal abnormality or genotype error), and 10 previously annotated second-degree relationships along with 38 other novel pairwise relationships had unexpected IBD2 (indicating two separate paths of recent ancestry). These newly described types of relatedness may impact the outcome of previous studies and should inform the design of future studies relying on the HapMap Phase III resource. PMID:23185369

Assessing the feasibility of a web-based registry for multiple orphan lung diseases: the Australasian Registry Network for Orphan Lung Disease (ARNOLD) experience

OpenAIRE

Casamento, K.; Laverty, A.; Wilsher, M.; Twiss, J.; Gabbay, E.; Glaspole, I.; Jaffe, A.

2016-01-01

Background We investigated the feasibility of using an online registry to provide prevalence data for multiple orphan lung diseases in Australia and New Zealand. Methods A web-based registry, The Australasian Registry Network of Orphan Lung Diseases (ARNOLD) was developed based on the existing British Paediatric Orphan Lung Disease Registry. All adult and paediatric respiratory physicians who were members of the Thoracic Society of Australia and New Zealand in Australia and New Zealand were s...

La genética de las poblaciones centroamericanas

OpenAIRE

Barrantes, Ramiro

2005-01-01

Las poblaciones centroamericanas no han sido objeto de muchos estudios genéticos con la excepción de análisis esporádicos de la variación entre y dentro de los grupos amerindios y de origen africano ubicados en el área. No obstante, en los últimos 15 años se efectuaron investigaciones sistemáticas en este sentido incluyendo poblaciones mestizas, particularmente las de Costa Rica y Panamá. En los amerindios se efectuaron estudios detallados de su estructura genética y las relaciones filogenéti...

Anesthesia for a patient of acromesomelic dysplasia with associated hydrocephalus, Arnold Chiari malformation and syringomyelia

Directory of Open Access Journals (Sweden)

Rudrashish Haldar

2013-01-01

Full Text Available Acromesomelic dysplasias are autosomal recessive osteochondrodysplasias. Acromesomelic dysplasia Maroteaux-type (AMDM, also known as St Helena dysplasia, is of two types: The classical and the mild variety. About 50 cases of AMDM have been reported till date, most of them being the classical variety. There is scarcity of literature on anesthesia for such patients. We are reporting a case of general anesthetic management of AMDM, associated with hydrocephalus, Arnold Chiari malformation type-1 and syringomyelia. The patient was a 10-year-old short-statured boy who presented with symptomatic thoracic kyphoscoliosis, gibbus deformity and back pain. On examination, there was no neurological deficit. Radiology revealed thoracic kyphoscoliosis, mild ventriculomegaly and upper cervical syringomyelia. The patient underwent posterior fossa decompression in the prone position under general anesthesia. We will discuss the anesthetic considerations for such patients and review the pertinent literature.

Modulating the distribution of fluxes among respiration and fermentation by overexpression of HAP4 in Saccharomyces cerevisiae.

NARCIS (Netherlands)

van Maris, A.J.A.; Bakker, B.M.; Brandt, M.; Boorsma, A.; Teixeira de Mattos, M.J.; Grivell, L.A.; Pronk, J.T.

2001-01-01

The tendency of Saccharomyces cerevisiae to favor alcoholic fermentation over respiration is a complication in aerobic, biomass-directed applications of this yeast. Overproduction of Hap4p, a positive transcriptional regulator of genes involved in respiratory metabolism, has been reported to

HDPE-Al2O3-HAp composites for biomedical applications: processing and characterizations.

Science.gov (United States)

Nath, Shekhar; Bodhak, Subhadip; Basu, Bikramjit

2009-01-01

The objective of this work is to demonstrate how the stiffness, hardness, as well as the biocompatibility property, of bioinert high-density polyethylene (HDPE) can be significantly improved by the combined addition of both bioinert and bioactive ceramic fillers. For this purpose, different volume fractions of hydroxyapatite and alumina, limited to a total of 40 vol %, have been incorporated in HDPE matrix. All the hybrid composites and monolithic HDPE were developed under optimized hot pressing condition (130 degrees C, 0.5 h, 92 MPa pressure). The results of the mechanical property characterization reveal that higher elastic modulus (6.2 GPa) and improved hardness (226.5 MPa) could be obtained in the developed HDPE-20 vol %-HAp-20 vol % Al(2)O(3) composite. Under the selected fretting conditions against various counterbody materials (steel, Al(2)O(3), and ZrO(2)), an extremely low COF of (0.07-0.11) and higher wear resistance (order of 10(-6) mm(3)/Nm) are obtained with the HDPE/20 vol % HAp/20 vol % Al(2)O(3) composite in both air and simulated body fluid environment. Importantly, in-vitro cell culture study using L929 fibroblast cells confirms favorable cell adhesion properties in the developed hybrid composite. (c) 2008 Wiley Periodicals, Inc.

National and sub-national age-sex specific and cause-specific mortality and disability-adjusted life years (DALYs) attributable to household air pollution from solid cookfuel use (HAP) in Iran, 1990-2013.

Science.gov (United States)

Abtahi, Mehrnoosh; Koolivand, Ali; Dobaradaran, Sina; Yaghmaeian, Kamyar; Mohseni-Bandpei, Anoushiravan; Khaloo, Shokooh Sadat; Jorfi, Sahand; Saeedi, Reza

2017-07-01

National and sub-national mortality, years of life lost due to premature mortality (YLLs), years lived with disability (YLDs) and disability-adjusted life years (DALYs) for household air pollution from solid cookfuel use (HAP) in Iran, 1990-2013 were estimated based on the Global Burden of Disease Study 2013 (GBD 2013). The burden of disease attributable to HAP was quantified by the comparative risk assessment method using four inputs: (1) exposure to HAP, (2) the theoretical minimum risk exposure level (TMREL), (3) exposure-response relationships of related causes (4) disease burden of related causes. All across the country, solid fuel use decreased from 5.26% in 1990 to 0.15% in 2013. The drastic reduction of solid fuel use leaded to DALYs attributable to HAP fell by 97.8% (95% uncertainty interval 97.7-98.0%) from 87,433 (51072-144303) in 1990 to 1889 (1016-3247) in 2013. Proportion of YLLs in DALYs from HAP decreased from 95.7% in 1990 to 86.6% in 2013. Contribution of causes in the attributable DALYs was variable during the study period and in 2013 was in the following order: ischemic heart disease for 43.4%, chronic obstructive pulmonary disease for 24.7%, hemorrhagic stroke for 9.7%, lower respiratory infections for 9.3%, ischemic stroke for 7.8%, lung cancer for 3.4% and cataract for 1.8%. Based on the Gini coefficient, the spatial inequality of the disease burden from HAP increased during the study period. The remained burden of disease was relatively scarce and it mainly occurred in seven southern provinces. Further reduction of the disease burden from HAP as well as compensation of the increasing spatial inequality in Iran could be attained through an especial plan for providing cleaner fuels in the southern provinces. Copyright © 2017 Elsevier Inc. All rights reserved.

A Gas Chromatographic Continuous Emissions Monitoring System for the Determination of VOCs and HAPs.

Science.gov (United States)

Coleman, William M; Gordon, Bert M

1996-01-01

This article describes a new gas chromatography-based emissions monitoring system for measuring volatile organic compounds (VOCs) and hazardous air pollutants (HAPs). The system is composed of a dual-column gas chromatograph equipped with thermal conductivity detectors, in which separation is optimized for fast chromatography. The system has the necessary valving for stream selection, which allows automatic calibration of the system at predetermined times and successive measurement of individual VOCs before and after a control device. Nine different VOCs (two of which are HAPs), plus methane (CH4) and carbon dioxide (CO2) are separated and quantified every two minutes. The accuracy and precision of this system has been demonstrated to be greater than 95%. The system employs a mass flow measurement device and also calculates and displays processed emission data, such as control device efficiency and total weight emitted during given time periods. Two such systems have been operational for one year in two separate gravure printing facilities; minimal upkeep is required, about one hour per month. One of these systems, used before and after a carbon adsorber, has been approved by the pertinent local permitting authority.

Estimating HAPs and radionuclide emissions from a laboratory complex at a nuclear processing site

International Nuclear Information System (INIS)

Paul, R.A.; Faugl, T.

1993-01-01

A unique methodology was developed for conducting an air emission inventory (AEI) at a DOE nuclear processing facility. This methodology involved the use of computer-assisted design (CAD) drawings to document emission points, computerized process drawings to document industrial processes leading to emissions, and a computerized data base of AEI forms to document emission estimates and related process data. A detailed air emissions inventory for operating years 1985--1991 was recently implemented for the entire site using this methodology. One industrial area at the DOE Site is comprised of laboratory facilities that provide direct support to the nuclear reactor and recovery operations, developmental studies to support reactor and separation operations, and developmental studies to support waste handling and storage. The majority of the functions are conducted in a single large building complex wherein bench scale and pilot scale experiments are carried out involving radionuclides, hazardous air pollutants (HAP), and other chemicals reportable under the Clean Air Act Amendments (CAAA) and Superfund Amendments and Re-authorization Act (SARA) Title 111. The results of the inventory showed that HAP and radionuclide emissions from the laboratory complex were relatively minor

Traffic Generator (TrafficGen) Version 1.4.2: Users Guide

Science.gov (United States)

2016-06-01

the network with Transmission Control Protocol and User Datagram Protocol Internet Protocol traffic. Each node generating network traffic in an...TrafficGen Graphical User Interface (GUI) 3 3.1 Anatomy of the User Interface 3 3.2 Scenario Configuration and MGEN Files 4 4. Working with...for public release; distribution is unlimited. vi List of Figures Fig. 1 TrafficGen user interface

Corrosion, wettability and thrombogenicity investigation of ion beam modified HAP/Al{sub 2}O{sub 3}

Energy Technology Data Exchange (ETDEWEB)

Shikha, Deep; Shahid, Md.; Jha, Ush [Department of Chemistry, BIT Mesra, Ranchi 835215 (India); Sinha, Sanjay Kumar, E-mail: sksinha@bitmesra.ac.in [Department of Physics, BIT Mesra, Ranchi 835215 (India); Reddy, V. Raghavendra [UGC-DAE Consortium for Scientific Research Indore (India); Ojha, Sunil; Kumar, P.; Kanjilal, Dinakar [IUAC, Aruna Asaf Ali road, New Delhi (India)

2015-08-01

Hydroxyapatite Ca{sub 10}(PO4){sub 6}(OH){sub 2}, is a biosensitive ceramic which promotes bone growth in human fluid. However due to its weak mechanical strength it is often coated on chemically inert material such as alumina. In the present work hydroxyapatite (HAP) of thickness 1 μm is deposited on alumina using sol–gel process and the stoichiometric ratio of Ca:P = 1.67 is maintained. Surface property of HAP is further improved by Ar{sup +} ion implantation. The samples were irradiated with 1.4 MeV Ar{sup +} ions with fluence ranging from 5 × 10{sup 14} to 1 × 10{sup 16} ions/cm{sup 2}. After irradiation, the surface is characterized using Atomic Force Microscope (AFM), Scanning Electron Microscope (SEM), electron dispersive X-ray spectroscopy (EDX), Glancing incidence X-ray diffraction (GXRD) and Rutherford backscattering Spectroscopy (RBS) techniques. Corrosion resistances and impedance analysis were carried out in Ringer solution. RBS and EDX were used to confirm the stoichiometric ratio of the film. Compound formation before and after ion implantation was studied using GXRD. Nanohardness, wettability and thrombogenicity of all the samples were studied. Correlation among surface morphology, improvement in corrosion resistance, hardness, wetability and thrombogenicity before and after ion implantation are discussed in this paper. - Highlights: • .People have worked on HAP coated on metallic alloy and even alumina but the characterization done here are all different. • Throbmobogenicity, corrosion resistance and wetability have all been carried out first time. • Improvement of Surface and interface using energetic inert ions like argon is carried out first time. • The best ion fluence for orthopaedic implants is proposed.

TRANSFER GEN ANTIVIRUS PADA EMBRIO UDANG WINDU, Penaeus monodon DALAM BERBAGAI KONSENTRASI DEOXYRIBO NUCLEIC ACID

Directory of Open Access Journals (Sweden)

Andi Parenrengi

2011-12-01

Full Text Available Teknologi transgenesis khususnya rekayasa genetik untuk menghasilkan udang windu resisten penyakit merupakan salah satu strategi yang dapat dilakukan dalam upaya pemecahan masalah penyakit yang menimpa budidaya udang windu. Teknologi transgenesis khususnya transfer gen antivirus pada udang windu telah berhasil dilakukan melalui teknik transfeksi. Meskipun demikian optimalisasi komponen teknologi tersebut masih perlu dilakukan. Konsentrasi DNA gen merupakan salah satu komponen teknologi transgenesis yang harus dioptimalkan untuk mendapatkan efisiensi dalam transfer gen. Penelitian bertujuan untuk mengetahui konsentrasi DNA gen antivirus yang optimal sebagai bahan transfer gen ke embrio menggunakan metode transfeksi. Embrio udang windu yang diperoleh dari hasil pemijahan induk asal Aceh, dikoleksi 5-10 menit setelah memijah dengan kepadatan 625 telur/2 mL. Transfeksi dilakukan dengan menggunakan media larutan transfeksi jetPEI dengan konsentrasi DNA gen antivirus sebagai perlakuan, yakni: 5, 10, dan 15 µg serta kontrol positif (tanpa plasmid DNA dan negatif (tanpa plasmid DNA dan larutan transfeksi, masing-masing 3 ulangan. Embrio hasil transfeksi ditetaskan pada stoples berisi air laut sebanyak 2 L yang diletakkan pada waterbath. Hasil penelitian menunjukkan bahwa gen antivirus telah berhasil diintroduksi ke embrio udang windu. Hasil analisis ragam menunjukkan bahwa perbedaan konsentrasi DNA (5-15 µg tidak berpengaruh nyata (P>0,05 terhadap daya tetas embrio udang windu. Analisis ekspresi gen pada larva udang windu juga menunjukkan adanya aktivitas ekspresi gen antivirus pada semua perlakuan konsentrasi DNA, di mana ekspresi gen antivirus pada larva transgenik lebih tinggi dibandingkan dengan kontrol (tanpa transfeksi. Sintasan pasca-larva PL-1 yang didapatkan pada penelitian ini adalah 12,0%; 10,0%; 10,6%; 12,3%; dan 14,2% masing-masing untuk perlakuan konsentrasi plasmid DNA 5 µg, 10 µg, 15 µg, kontrol positif dan negatif, di mana

The biosorption of Cd2+ ions by wood pulp of Pinus negra Arnold

International Nuclear Information System (INIS)

Loucka, T.; Janos, P.

2001-01-01

Biosorption is one of those processes that use biomass (mostly inanimate) for elimination of various chemical substances (e.g. heavy metals) from environment. Until now algae have been studied as bio-sorbents in most cases, but we can also take advantage of wood pulp (or sawdust) that is normal waste material resulting in large amounts from various productions. Considering the fact that bio-sorbent can be taken as natural ion exchanger containing slightly acidic or basic functional groups (2,3,4), it is necessary to suppose that part of functional groups is filled by various metals before starting the measurements. Substituting these bound metallic cations by protonization we can gain biomass in given condition and some important information about the content of cations bound to bio-sorbent through ion exchange. The material used for biosorption observation was sawdust of Pinus negra Arnold. For measurements we used the part which passed through the 0.6 mm sieve. By dehydrating at the 1200 C for the time of 24 hours we gained the water part that was 5.44% of original weight

Malformación de Arnold-Chiari: la pérdida de la sonrisa

Directory of Open Access Journals (Sweden)

Antonio Martínez-Sabater

2014-12-01

Full Text Available La Malformación de Arnold-Chiari es una enfermedad rara caracterizada por la presencia de síntomas insidiosos que pueden suponer un retraso en el diagnóstico. Las características sintomatológicas como el dolor, la pérdida de fuerza progresiva, los mareos, etc., junto con los efectos secundarios de los fármacos indicados para el tratamiento sintomático (anticonvulsionantes, antidepresivos, analgésicos, etc. supone una pérdida de la calidad de vida de la persona. Aspectos de la calidad de vida que en un entorno biomédico suelen pasar desapercibidos, y juntamente, con la falta de repercusión exterior de la patología, supone la incomprensión de las personas del entorno. Con el fin de poder conocer las percepciones y experiencias de una persona afecta se ha utilizado la historia de vida, presentando la historia de Javi, que por su doble vertiente de persona afecta y personal sanitario, se convierte en informante clave.

Who will save the tokamak - Harry Potter, Arnold Schwarzenegger, or Shaquille O'Neil?

Science.gov (United States)

Freidberg, J.; Mangiarotti, F.; Minervini, J.

2014-10-01

The tokamak is the current leading contender for a fusion power reactor. The reason for the preeminence of the tokamak is its high quality plasma physics performance relative to other concepts. Even so, it is well known that the tokamak must still overcome two basic physics challenges before becoming viable as a DEMO and ultimately a reactor: (1) the achievement of non-inductive steady state operation, and (2) the achievement of robust disruption free operation. These are in addition to the PMI problems faced by all concepts. The work presented here demonstrates by means of a simple but highly credible analytic calculation that a ``standard'' tokamak cannot lead to a reactor - it is just not possible to simultaneously satisfy all the plasma physics plus engineering constraints. Three possible solutions, some more well-known than others, to the problem are analyzed. These visual image generating solutions are defined as (1) the Harry Potter solution, (2) the Arnold Schwarzenegger solution, and (3) the Shaquille O'Neil solution. Each solution will be described both qualitatively and quantitatively at the meeting.

Mejoramiento genético acelerado de angiospermas perennes vía inducción floral por sobre-expresión del gen FT

Directory of Open Access Journals (Sweden)

Rafael Urrea López

2018-05-01

Full Text Available Los bosques y selvas enfrentan el reto de satisfacer la demanda por recursos de una población en crecimiento, así como la amenaza del rápido cambio climático que exacerba la magnitud y frecuencia de estreses bióticos y abióticos. Para ello, es urgente acelerar el mejoramiento genético de especies forestales. Sin embargo, sus largas etapas juveniles y asincronía floral retrasan peligrosamente este proceso. El presente ensayo explora los adelantos biotecnológicos en inducción floral y su potencial aplicación en especies forestales. Entre los genes identificados y caracterizados que participan en la ruta de señalización de la floración, especial atención se destina al gen FLOWERING LOCUS T, considerado un integrador de rutas de señalización altamente conservado entre las angiospermas, que, al sobre-expresarse por ingeniería genética, es capaz de inducir la floración de forma eficiente. Esta novedosa estrategia biotecnológica se ha utilizado, recientemente, para segregar genes de resistencia a enfermedades, en un menor tiempo, en germoplasma comercial de manzana y ciruela. Permite soslayar barreras naturales que por mucho tiempo han restringido a las especies forestales al mejoramiento por selección, principalmente. Entre sus ventajas está la de poder restringirla al proceso y no al producto, para acelerar las cruzas sexuales sin modificar genéticamente la progenie; se aleja así de la controversia alrededor de la liberación y consumo de organismos genéticamente modificados, y de los costos y trámites obligatorios para los OGM para monitoreo de posibles riesgos. Se proyecta como una tecnología que puede acelerar, significativamente, el mejoramiento de especies forestales.

The interaction between Otto fuel II and aqueous hydroxylammonium perchlorate (HAP). Pt. 3: depletion of components within the reacting liquids

Energy Technology Data Exchange (ETDEWEB)

Bellerby, John M.; Blackman, Christopher S. [Department of Environmental and Ordnance Systems, Cranfield University, Defence College of Management and Technology, Shrivenham, Swindon SN6 8LA (United Kingdom)

2007-06-15

Gas chromatography (GC) with a Flame Ionisation Detector (FID) has been used to determine changes in the concentrations of the components of Otto Fuel II (OF) in contact with an 82% aqueous solution of hydroxylammonium perchlorate (HAP) in sealed vials at 31.7 C during the period leading up to auto-ignition of the two liquids. The concentration of hydroxylamine in HAP was monitored over the same period using a titration method. It was found that 2-nitrodiphenylamine (2NDPA), the stabiliser in the OF, is completely consumed after about 65-70 h and that the concentration of hydroxylamine begins to fall at this point. 1,2-Propanediol dinitrate (propylene glycol dinitrate, PGDN), the energetic component in the OF, is not depleted significantly until after about 90 h. The evolution of nitrous oxide (N{sub 2}O) between 65 and 90 h is attributed to the reaction of the hydroxylammonium ion with nitrous acids produced by PGDN decomposition at the liquid-liquid interface. Carbon dioxide (CO{sub 2}) is evolved after 90 h and is attributed to PGDN decomposition. HAP and PGDN are each thought to contribute to N{sub 2}O evolution after 90 h. (Abstract Copyright [2007], Wiley Periodicals, Inc.)

Aconselhamento genético Genetic counseling

Directory of Open Access Journals (Sweden)

João Monteiro de Pina-Neto

2008-08-01

Full Text Available OBJETIVO: Esta revisão sobre aconselhamento genético (AG teve o objetivo de mostrar os conceitos atuais e os princípios filosóficos e éticos aceitos na grande maioria dos países e recomendados pela Organização Mundial da Saúde, as fases do processo, seus resultados e o impacto psicológico de uma doença genética em uma família. FONTES DOS DADOS: Os conceitos apresentados são baseados em uma síntese histórica da literatura sobre AG desde a década de 1930 até o momento atual, sendo que os artigos citados representam os principais trabalhos publicados e que hoje fundamentam a teoria e a prática do AG. SÍNTESE DOS DADOS: O AG modernamente é definido como um processo de comunicação que trata dos problemas humanos relacionados à ocorrência de uma doença genética em uma família. É fundamental que os profissionais da saúde conheçam os aspectos psicológicos desencadeados pela doença genética e como estes aspectos podem ser manejados. Vivemos ainda na genética humana e médica uma fase de predomínio dos aspectos técnicos e científicos e de pouca ênfase no estudo das reações emocionais e dos processos de adaptação das pessoas a estas doenças, o que leva ao baixo entendimento dos clientes sobre os fatos ocorridos, com conseqüências negativas sobre a vida familiar e para a sociedade. CONCLUSÕES: Conclui-se pela necessidade de que as famílias com doenças genéticas sejam encaminhadas para AG e que os profissionais desta área invistam mais na humanização do atendimento, desenvolvendo mais as técnicas do AG psicológico não-diretivo.OBJECTIVE: The objective of this review of genetic counseling (GC is to describe the current concepts and philosophical and ethical principles accepted by the great majority of countries and recommended by the World Health Organization, the stages of the process, its results and the psychological impact that a genetic disease has on a family. SOURCES: The concepts presented are

Estudio de la variabilidad genética en camélidos bolivianos

OpenAIRE

Barreta Pinto, Julia

2013-01-01

El estudio de los camélidos sudamericanos es de gran interés en los países andinoscomo Perú, Bolivia, Chile, Argentina, debido a su importante valor económico y suimportancia en el mantenimiento y desarrollo de las poblaciones rurales en dichos países. Dada la falta de estudios genéticos centrados en las poblaciones de camélidos quehabitan en Bolivia, y la necesidad de realizar una valoración de la diversidad genética deestas poblaciones, la presente Tesis doctoral ha abordado el estudio gené...

ASN’s actions in GEN IV reactors and Sodium Fast Reactors (SFR)

International Nuclear Information System (INIS)

Belot, Clotilde

2013-01-01

The ASN is involved in 3 actions concerning GEN IV: • Overview of nuclear reactor GEN IV systems; • Specific analysis about transmutation; • Prototype reactor ASTRID (SFR). Furthermore theses actions are in the beginning (no conclusions or results available)

Evaluation of Effective Parameters on Labeling of Hydroxyapatite Compound with 90Y and Introducing the Best Method to Produce 90Y-HAp Radiopharmaceutical for Radio synovectomy

International Nuclear Information System (INIS)

Davarpanah, M. R.; Khoshhosn, H. A.; Attar Nosrati, S.; Harati, S. M.; Aghamiri, S. M.; Ghannadi Maragheh, M.

2012-01-01

Radio synovectomy is a local intra-articular injection of radionuclides in colloidal form for treatment of articular inflammatory in rheumatoid arthritis, hemophilia or orthopedic troubles. β-emitting radionuclides can be used for various joints based on radiation energy. 90 Y is a pure β-emitter with a half-life of 64.1 hours that is used for treatment of the knee joint. β-radiation of this radionuclide possesses maximum energy of 2.281 MeV (99.98%), mean pathway of 3.6 mm in the soft tissue and maximum 11 mm. In this project, hydroxyapatite (HAp) is applied as a colloid maker agent that interacts with 90 Y 3+ ions via ion-dipole bonds and produces 90 Y-HAp. The colloidal pharmaceutical is produced by adding an acidic solution of 90 YCl 3 to an HAp suspension in saline. Effective parameters within which the colloid is applied, such as the volume of diluent, HAp particle size and sonication effect were evaluated and tested. First, these determinative parameters were optimized in the simulated conditions and then examined in the active phase. Finally, the best procedure was determined for the production of the radiopharmaceutical. Radionuclide purity of the radiopharmaceutical according to the primary 90 YCl 3 solution was over 99.9%. Labeling yield and radiochemical purity were obtained over 99% using TLC method in saline solvent up to three days after production of radiopharmaceutical. Radiochemical purity of 90 Y-HAp colloid was also evaluated in human serum albumin solution for three days at room temperature. The amount of released activity was between 0.3 to 2%.

Performance Evaluation of Hap-Free Paint Strippers vs. Methylene-Chloride-Based Strippers for Removing Army Chemical Agent Resistant Coatings (CARC)

National Research Council Canada - National Science Library

Kelley, John; Considine, Thomas

2006-01-01

...). The purpose of this effort is to investigate HAP-free alternative chemical paint strippers as potential replacements for the methylene-chloride- based chemical strippers currently used in both processes...

SIPSMetGen: It's Not Just For Aircraft Data and ECS Anymore.

Science.gov (United States)

Schwab, M.

2015-12-01

The SIPSMetGen utility, developed for the NASA EOSDIS project, under the EED contract, simplified the creation of file level metadata for the ECS System. The utility has been enhanced for ease of use, efficiency, speed and increased flexibility. The SIPSMetGen utility was originally created as a means of generating file level spatial metadata for Operation IceBridge. The first version created only ODL metadata, specific for ingest into ECS. The core strength of the utility was, and continues to be, its ability to take complex shapes and patterns of data collection point clouds from aircraft flights and simplify them to a relatively simple concave hull geo-polygon. It has been found to be a useful and easy to use tool for creating file level metadata for many other missions, both aircraft and satellite. While the original version was useful it had its limitations. In 2014 Raytheon was tasked to make enhancements to SIPSMetGen, this resulted a new version of SIPSMetGen which can create ISO Compliant XML metadata; provides optimization and streamlining of the algorithm for creating the spatial metadata; a quicker runtime with more consistent results; a utility that can be configured to run multi-threaded on systems with multiple processors. The utility comes with a java based graphical user interface to aid in configuration and running of the utility. The enhanced SIPSMetGen allows more diverse data sets to be archived with file level metadata. The advantage of archiving data with file level metadata is that it makes it easier for data users, and scientists to find relevant data. File level metadata unlocks the power of existing archives and metadata repositories such as ECS and CMR and search and discovery utilities like Reverb and Earth Data Search. Current missions now using SIPSMetGen include: Aquarius, Measures, ARISE, and Nimbus.

Comparison of HapMap and 1000 Genomes Reference Panels in a Large-Scale Genome-Wide Association Study

DEFF Research Database (Denmark)

de Vries, Paul S; Sabater-Lleal, Maria; Chasman, Daniel I

2017-01-01

An increasing number of genome-wide association (GWA) studies are now using the higher resolution 1000 Genomes Project reference panel (1000G) for imputation, with the expectation that 1000G imputation will lead to the discovery of additional associated loci when compared to HapMap imputation. In...

O futuro da epidemiologia genética de características complexas

Directory of Open Access Journals (Sweden)

Feitosa Mary F.

2002-01-01

Full Text Available A epidemiologia genética evoluiu de um enfoque em estudos sobre doenças mendelianas raras para a análise genética de características complexas. Com o advento de informações sobre a completa seqüência de genes ao longo do genoma humano e de outros organismos, o interesse da epidemiologia genética em desvendar a natureza dos fatores que influenciam essas características se tornou primordial. São apresentados os principais métodos empregados no estudo de doenças complexas bem como suas principais vantagens e desvantagens. Discute-se a importância na determinação da amostra e o uso de fenótipos e marcadores genéticos apropriados. Como exemplo das estratégias citadas tomamos o estudo de índice de massa corporal (BMI para ilustrar um fator genético principal localizado no cromossomo 7. Em uma discussão sobre tendências no estudo de ligação, embora reconhecendo que famílias e genealogias continuarão sendo o foco principal das amostras, discute-se alguns novos e eficientes tipos de amostragem (como por exemplo, controles não-relacionados em que amostras de conjunto de DNA serão universalmente empregadas. O reconhecimento da heterogeneidade genética entre estudos e sua interpretação será uma das mais importantes características no futuro das análises de características complexas.

Doping Genético e Eugenia: Diálogos além do esporte

Directory of Open Access Journals (Sweden)

Tiago Vieira Bomtempo

2016-01-01

Full Text Available La ingeniería genética trajo posibilidades antes inimaginables, en la que no hace mucho tiempo era visto sólo en las películas. De la terapia génica, dirigida hacia una corrección o cura de una enfermedad, pasa a la posibilidad del mejoramiento genético, actualmente vislumbrado en el mundo del deporte con el doping genético. ¿Pero, el doping genético no estaría violando el derecho al patrimonio genético no modificado? Aunque la intervención genética no se transmita a los descendentes, habría un mejoramiento genético, que afectaría el genoma del atleta y lo diferenciaría de los demás atletas y otros individuos, hiriendo el principio de igualdad en detrimento de la autonomía privada, pudiéndose estar hablando inicialmente de una relación de dominación, aunque sea en razón al rendimiento físico en el deporte. En este sentido, estas innovaciones que atraviesan el campo de la ingeniería genética, infunden una preocupación acerca de la manipulación genética en las generaciones futuras, punto de discusión no sólo biomédica, sino también bioético y biojurídico. Así, surge una preocupación si estos nuevos avances pueden afectar a la dignidad humana delante de una posible eugenesia, debido a la proyección de personas y la consecuente discriminación por determinada identidad genética. Junto a esto, el objetivo de este artículo es investigar si el dopaje genético ofendería el derecho al patrimonio genético no modificado y los derechos de las generaciones futuras, dando lugar a una nueva forma de eugenesia, al no permitir el ejercicio igualitario de las libertades fundamentales. Por lo tanto, se hace necesaria una investigación basada en los autores de la bioética y el bioderecho, así como también los textos legales nacionales e internacionales que involucran el tema. Es indispensable la discusión de estas cuestiones, sobre todo con la proximidad de los Juegos Olímpicos de Verano en Brasil en este año 2016

Restoration of the efferent phase of the sneeze reflex after regression of an Arnold-Chiari malformation with compression of the medulla oblongata.

Science.gov (United States)

Songu, Murat; Can, Nazan; Gelal, Fazil

2013-01-01

The precise location of the sneeze center in the human brain has not been definitively identified. The aim of this report is to contribute to the effort to detect its location. We report the case of a 13-year-old boy who presented to our outpatient clinic for evaluation of an inability to sneeze. In an attempt to trigger the afferent (nasal) phase of the sneeze reflex, we first applied a cotton swab and later a silver nitrate stick to the patient's nasal mucosa. Once that was accomplished, we observed that the patient could not complete the efferent (expiratory) phase of the sneeze reflex, and thus he did not sneeze. Cranial magnetic resonance imaging (MRI) revealed that his cerebellar tonsils extended approximately 10 mm inferiorly through the foramen magnum, which represented a type I Arnold-Chiari malformation. The tonsils were noted to have compressed the posterolateral portion of the medulla oblongata. At follow-up 21 months later, we noted that the patient was able to sneeze spontaneously as well as with nasal stimulation. Repeat MRI revealed that the Arnold-Chiari malformation had undergone a spontaneous partial regression, which resulted in relief of the compression of the medulla oblongata. We believe that the patient's earlier inability to sneeze might have been attributable to the compression of the medulla oblongata by the cerebellar tonsils and that the site of the compression might represent the location of his sneeze center.

Microsatélites, distancias genéticas y estructura de poblaciones nativas sudamericanas

Directory of Open Access Journals (Sweden)

Demarchi, Darío Alfredo

2009-01-01

Full Text Available En este trabajo se investigaron las relaciones genéticas entre 17 poblaciones nativas sudamericanas en relación a 15 microsatélites (STRs autosómicos, utilizando 3 distancias genéticas- DST, DAy (δu2-que se ajustan a diferentes postulados teóricos. A través de diferentes técnicas de análisis (escalamiento multidimensional, correlación y correlación parcial de matrices se puso a prueba si las distancias genéticas reflejaban las relaciones interpoblacionales esperadas a partir de la distribución geográfica o de relaciones lingüísticas entre las poblaciones. Además, se estimó en que grado las distintas medidas de distancias genéticas eran influenciadas por la diversidad (He de cada población. Los mapas genéticos muestran, principalmente para DST y DA, que las poblaciones aisladas y con bajo tamaño efectivo (Ne aparecen como outliers, mientras que las poblaciones con alto Ne y mayor flujo génico ocupan una posición central a bajos valores de distancia unas de otras y sin un patrón definido de agrupamiento. La falta de asociación entre distancias genéticas y lingüísticas o geográficas y por otra parte, la alta correlación negativa entre He y distancias génicas promedio por población confiman ese patrón, demostrando que la mayor parte de la variación interpoblacional puede ser explicada en función del grado de diversidad intrapoblacional. Es decir, las distancias genéticas no reflejan relaciones filogenéticas, lingüísticas o geográficas, sino más bien eventos demográficos recientes tales como cuellos de botella genético, efecto fundador o migración externa masiva. Este hecho puede ser comprobado por medio de otra metodología analítica, el modelo de Harpending y Ward.

Safer Systems: A NextGen Aviation Safety Strategic Goal

Science.gov (United States)

Darr, Stephen T.; Ricks, Wendell R.; Lemos, Katherine A.

2008-01-01

The Joint Planning and Development Office (JPDO), is charged by Congress with developing the concepts and plans for the Next Generation Air Transportation System (NextGen). The National Aviation Safety Strategic Plan (NASSP), developed by the Safety Working Group of the JPDO, focuses on establishing the goals, objectives, and strategies needed to realize the safety objectives of the NextGen Integrated Plan. The three goal areas of the NASSP are Safer Practices, Safer Systems, and Safer Worldwide. Safer Practices emphasizes an integrated, systematic approach to safety risk management through implementation of formalized Safety Management Systems (SMS) that incorporate safety data analysis processes, and the enhancement of methods for ensuring safety is an inherent characteristic of NextGen. Safer Systems emphasizes implementation of safety-enhancing technologies, which will improve safety for human-centered interfaces and enhance the safety of airborne and ground-based systems. Safer Worldwide encourages coordinating the adoption of the safer practices and safer systems technologies, policies and procedures worldwide, such that the maximum level of safety is achieved across air transportation system boundaries. This paper introduces the NASSP and its development, and focuses on the Safer Systems elements of the NASSP, which incorporates three objectives for NextGen systems: 1) provide risk reducing system interfaces, 2) provide safety enhancements for airborne systems, and 3) provide safety enhancements for ground-based systems. The goal of this paper is to expose avionics and air traffic management system developers to NASSP objectives and Safer Systems strategies.

Genetic similarity between coriander genotypes using ISSR markers Similaridade genética entre genótipos de coentro por marcadores ISSR

Directory of Open Access Journals (Sweden)

Roberto de A Melo

2011-12-01

Full Text Available With the development of new cultivars, a precise genetic characterization is essential for improvement programs or for cultivar registration and protection. Molecular markers have been complementing the traditional morphological and agronomic characterization techniques because they are virtually unlimited, cover the whole genome and are not environmentally influenced. Genetic characterization constitutes the basis for studies involving estimates of genetic similarity. Therefore, the objective of the present study was to evaluate the genetic similarity between ten coriander genotypes (nine cultivars and one line using ISSR markers. The cultivars used were: Americano, Asteca, Palmeira, Português, Santo, Supéria, Tabocas, Tapacurá, Verdão and the experimental line HTV-9299. The genetic similarity between the cultivars was estimated using 227 banded regions of ISSR molecular markers. The UBC 897 oligonucleotide generated the highest number of fragments (16, resulting in a higher polymorphism. The results indicate that the twenty-nine oligonucleotides chosen were satisfactory for detecting polymorphism. Based on the grouping analysis determined from the similarity data, there were two groups and two sub-groups. The calculated similarity for the genotypes varied from 52 to 75%. The lowest similarity was observed between Português and Verdão, at 52%. The highest similarity was found between Português and Palmeira, at 75%. The ISSR is efficient for identifying DNA polymorphism in coriander.Com o surgimento de novas cultivares, uma caracterização genética precisa é essencial, visando à utilização em programas de melhoramento ou para fins de registros e ou proteção de cultivares. Marcadores moleculares vêm complementando a caracterização morfológica e agronômica tradicional, uma vez que são virtualmente ilimitados, cobrem todo o genoma e não são influenciados pelo ambiente. A caracterização genética constitui a base para

Crystal Structure of a Eukaryotic GEN1 Resolving Enzyme Bound to DNA

Directory of Open Access Journals (Sweden)

Yijin Liu

2015-12-01

Full Text Available We present the crystal structure of the junction-resolving enzyme GEN1 bound to DNA at 2.5 Å resolution. The structure of the GEN1 protein reveals it to have an elaborated FEN-XPG family fold that is modified for its role in four-way junction resolution. The functional unit in the crystal is a monomer of active GEN1 bound to the product of resolution cleavage, with an extensive DNA binding interface for both helical arms. Within the crystal lattice, a GEN1 dimer interface juxtaposes two products, whereby they can be reconnected into a four-way junction, the structure of which agrees with that determined in solution. The reconnection requires some opening of the DNA structure at the center, in agreement with permanganate probing and 2-aminopurine fluorescence. The structure shows that a relaxation of the DNA structure accompanies cleavage, suggesting how second-strand cleavage is accelerated to ensure productive resolution of the junction.

Detección de metabolitos de biodegradación de HAPS en suelos contaminados.

OpenAIRE

Calero Cáceres, William Ricardo

2012-01-01

Los Hidrocarburos Aromáticos Policíclicos (HAPs) son un grupo de contaminantes orgánicos persistentes comúnmente encontrados en emplazamientos industriales. En muchos casos, estos compuestos provienen de la creosota utilizada como presevante de la madera. Debido a su toxicidad y persistencia ambiental, en 1979 la Agencia de Protección Ambiental de Estados Unidos US EPA incluyó 16 de estos compuestos en la lista de contaminantes prioritarios (Keith & Telliard, 1976)...

Variable Step Closed Loop Power Control with Space Diversity for Low Elevation Angle High Altitude Platforms Communication Channel [Langkah Variabel Kontrol Daya Loop Tertutup dengan Keragaman Ruang untuk Sudut Elevasi Rendah pada Kanal Komunikasi HAPs

Directory of Open Access Journals (Sweden)

Iskandar Iskandar

2016-07-01

Full Text Available This paper proposes variable step closed loop power control algorithm combined with space diversity to improve the performance of High Altitude Platforms (HAPs communication at low elevation angle using Code Division Multiple Access (CDMA. In this contribution, we first develop HAPs channel model which is derived from experimental measurement. From our experiment, we found HAPs channel characteristic can be modeled as a Ricean distribution because the presence of line of sight path. Different elevation angle resulting different K factor value.  This value is then used in Signal to Interference Ratio (SIR based closed loop power control evaluation. The variable step algorithm is simulated under various elevation angles with different speed of mobile user. The performance is presented in terms of user elevation angle, user speed, step size and space diversity order. We found that the performance of variable step closed-loop power control less effective at low elevation angle. However our simulation shows that space diversity is able to improve the performance of closed loop power control for HAPs channel at low elevation angle.*****Kajian ini mengusulkan suatu algoritma kontrol daya langkah variabel loop tertutup dikombinasikan dengan keragaman ruang untuk meningkatkan kinerja komunikasi High Altitude Platforms(HAPs pada sudut elevasi rendah menggunakan Code Division Multiple Access (CDMA. Kami berkontribusi untuk mengembangkan model kanal HAPs yang berasal dari pengukuran eksperimental sebelumnya. Dari percobaan tersebut, kami menemukan karakteristik kanal HAPs yang dapat dimodelkan sebagai distribusi Ricean karena kehadiran jalur tanpa penghalang. Eksperimen menunjukkan bahwa perbedaan sudut elevasi menghasilkan perbedaan nilai factor K. Nilai ini kemudian digunakan dalam Signal to Interference Ratio (SIR berbasiskan evaluasi kontrol daya loop tertutup. Algoritma langkah variabel disimulasikan dibawah sudut elevasi yang berbeda dengan kecepatan

Weak chaos in the disordered nonlinear Schroedinger chain: Destruction of Anderson localization by Arnold diffusion

International Nuclear Information System (INIS)

Basko, D.M.

2011-01-01

Research highlights: → In a one-dimensional disordered chain of oscillators all normal modes are localized. → Nonlinearity leads to chaotic dynamics. → Chaos is concentrated on rare chaotic spots. → Chaotic spots drive energy exchange between oscillators. → Macroscopic transport coefficients are obtained. - Abstract: The subject of this study is the long-time equilibration dynamics of a strongly disordered one-dimensional chain of coupled weakly anharmonic classical oscillators. It is shown that chaos in this system has a very particular spatial structure: it can be viewed as a dilute gas of chaotic spots. Each chaotic spot corresponds to a stochastic pump which drives the Arnold diffusion of the oscillators surrounding it, thus leading to their relaxation and thermalization. The most important mechanism of equilibration at long distances is provided by random migration of the chaotic spots along the chain, which bears analogy with variable-range hopping of electrons in strongly disordered solids. The corresponding macroscopic transport equations are obtained.

40 CFR Table 5 to Subpart U of... - Known Organic HAP Emitted From the Production of Elastomer Products

Science.gov (United States)

2010-07-01

... Rubber. EPI = Epichlorohydrin Rubber. EPR = Ethylene Propylene Rubber. HBR = Halobutyl Rubber. HYP = Hypalon TM. NEO = Neoprene. NBL = Nitrile Butadiene Latex. NBR = Nitrile Butadiene Rubber. PBR/SBRS... products] Organic HAP/chemical name (CAS No.) Elastomer product/subcategory BR EPI EPR HBR HYP NEO NBL NBR...

GenMapDB: a database of mapped human BAC clones

OpenAIRE

Morley, Michael; Arcaro, Melissa; Burdick, Joshua; Yonescu, Raluca; Reid, Thomas; Kirsch, Ilan R.; Cheung, Vivian G.

2001-01-01

GenMapDB (http://genomics.med.upenn.edu/genmapdb) is a repository of human bacterial artificial chromosome (BAC) clones mapped by our laboratory to sequence-tagged site markers. Currently, GenMapDB contains over 3000 mapped clones that span 19 chromosomes, chromosomes 2, 4, 5, 9–22, X and Y. This database provides positional information about human BAC clones from the RPCI-11 human male BAC library. It also contains restriction fragment analysis data and end sequen...

Surgical treatment of Arnold-Chiari malformation type I in an adult patient

Directory of Open Access Journals (Sweden)

Marković Marko

2008-01-01

Full Text Available Background. Herniation of the cerebellar tonsils through the foramen magnum into the cervical spinal canal with obliteration of the cerebellomedullary cistern is the primary feature of Arnold-Chiari type I malformation (ACM I. It is considered to be congenital malformation, although there have been reported cases of an acquired form. Case report. We presented a female patient, 45-year old, with ACM I without syringomyelia as a rare and unusual clinical image, as well as the effect of decompressive surgery in the treatment of this malformation. The patient was admitted to the Department of Neurosurgery with clinical signs of truncal ataxia worsening during the last six years. Moderate quadriparesis with predominant lower extremity involvement and the signs of the cranial nerves damages occured during the last seven months before admission, with progressive clinical course up to the date of admission. Neurosurgical treatment that included suboccipital medial craniectomy with resection of posterior arch C1 vertebrae and C2 laminectomy resulted in a significant clinical improvement and a much better quality of life. Conclusion. Posterior craniovertebral decompression with microsurgical reduction of the cerebellar tonsils and placement of an artificial dural graft is a treatment of choice in severe forms of ACM I without syringomyelia. .

Description of Guyruita gen. nov. and two new species (Ischnocolinae, Theraphosidae Descrição de Guyruita gen. nov. e duas novas espécies (Ischnocolinae, Theraphosidae

Directory of Open Access Journals (Sweden)

José P.L. Guadanucci

2007-12-01

Full Text Available The genus Guyruita gen. nov. and two new species from Brazil are described. Holothele waikoshiemi (Bertani & Araújo, 2005 from Venezuela is transferred here to the new genus. Guyruita gen. nov. differs from the remaining Ischnocolinae by the following features: labium densely occupied by a lot of cuspules (more than 100, intercheliceral intumescence absent, posterior sternal sigilla remote from margin, tarsal claws without teeth, tarsal scopula I-II undivided (tarsus II with a line of sparse setae, which does not divide the scopula, III-IV divided.É descrito o gênero Guyruita gen. nov. e duas espécies novas do Brasil. Holothele waikoshiemi (Bertani & Araújo, 2005 da Venezuela é transferido para o novo gênero. Guyruita gen. nov. difere dos outros Ischnocolinae pelas seguintes caracterísicas: lábio densamente ocupado por muitas cúspides (mais de 100, tumescência interqueliceral ausente, sigilla esternal posterior distante da margem, unhas tarsais sem dentes, escópula tarsal I e II inteiras (tarso II com uma fileira de cerdas esparsas, as quais não dividem a escópula, III e IV divididas.

What Is Physics Problem-Solving Competency? The Views of Arnold Sommerfeld and Enrico Fermi

Science.gov (United States)

Niss, Martin

2018-05-01

A central goal of physics education is to teach problem-solving competency, but the description of the nature of this competency is somehwat fragmentary and implicit in the literature. The present article uses recent historical scholarship on Arnold Sommerfeld and Enrico Fermi to identify and characterize two positions on the nature of physics problem-solving competency. The first, Sommerfeld's, is a "theory first, phenomenon second" approach. Here, the relevant problems originate in one of the theories of physics and the goal of the problem-solver is to make a mathematical analysis of the relevant equation(s) and then give a qualitative analysis of the phenomenon that arise from these mathematical results. Fermi's position is a "phenomenon first, theory second" approach, where the starting point is a physical phenomenon that is analyzed and then brought into the realm of a physics theory. The two positions are illustrated with solutions to two problems and it is shown that the two positions are reflected in problem collections of university educations in physics.

A Novel Role of Human Holliday Junction Resolvase GEN1 in the Maintenance of Centrosome Integrity

DEFF Research Database (Denmark)

Gao, M.; Danielsen, Jannie Michaela Rendtlew; Wei, L.-Z.

2012-01-01

but not catalytic activity of GEN1 is required for preventing centrosome hyper-amplification, formation of multiple mitotic spindles, and multi-nucleation. Our findings provide novel insight into the biological functions of GEN1 by uncovering an important role of GEN1 in the regulation of centrosome integrity....

Environmental Information for the U.S. Next Generation Air Transportation System (NextGen)

Science.gov (United States)

Murray, J.; Miner, C.; Pace, D.; Minnis, P.; Mecikalski, J.; Feltz, W.; Johnson, D.; Iskendarian, H.; Haynes, J.

2009-09-01

It is estimated that weather is responsible for approximately 70% of all air traffic delays and cancellations in the United States. Annually, this produces an overall economic loss of nearly 40B. The FAA and NASA have determined that weather impacts and other environmental constraints on the U.S. National Airspace System (NAS) will increase to the point of system unsustainability unless the NAS is radically transformed. A Next Generation Air Transportation System (NextGen) is planned to accommodate the anticipated demand for increased system capacity and the super-density operations that this transformation will entail. The heart of the environmental information component that is being developed for NextGen will be a 4-dimensional data cube which will include a single authoritative source comprising probabilistic weather information for NextGen Air Traffic Management (ATM) systems. Aviation weather constraints and safety hazards typically comprise meso-scale, storm-scale and microscale observables that can significantly impact both terminal and enroute aviation operations. With these operational impacts in mind, functional and performance requirements for the NextGen weather system were established which require significant improvements in observation and forecasting capabilities. This will include satellite observations from geostationary and/or polar-orbiting hyperspectral sounders, multi-spectral imagers, lightning mappers, space weather monitors and other environmental observing systems. It will also require improved in situ and remotely sensed observations from ground-based and airborne systems. These observations will be used to better understand and to develop forecasting applications for convective weather, in-flight icing, turbulence, ceilings and visibility, volcanic ash, space weather and the environmental impacts of aviation. Cutting-edge collaborative research efforts and results from NASA, NOAA and the FAA which address these phenomena are summarized

The GenABEL Project for statistical genomics.

Science.gov (United States)

Karssen, Lennart C; van Duijn, Cornelia M; Aulchenko, Yurii S

2016-01-01

Development of free/libre open source software is usually done by a community of people with an interest in the tool. For scientific software, however, this is less often the case. Most scientific software is written by only a few authors, often a student working on a thesis. Once the paper describing the tool has been published, the tool is no longer developed further and is left to its own device. Here we describe the broad, multidisciplinary community we formed around a set of tools for statistical genomics. The GenABEL project for statistical omics actively promotes open interdisciplinary development of statistical methodology and its implementation in efficient and user-friendly software under an open source licence. The software tools developed withing the project collectively make up the GenABEL suite, which currently consists of eleven tools. The open framework of the project actively encourages involvement of the community in all stages, from formulation of methodological ideas to application of software to specific data sets. A web forum is used to channel user questions and discussions, further promoting the use of the GenABEL suite. Developer discussions take place on a dedicated mailing list, and development is further supported by robust development practices including use of public version control, code review and continuous integration. Use of this open science model attracts contributions from users and developers outside the "core team", facilitating agile statistical omics methodology development and fast dissemination.