WorldWideScience

Sample records for gbm briefing book

  1. The nuclear materials control technology briefing book

    Energy Technology Data Exchange (ETDEWEB)

    Hartwell, J.K.; Fernandez, S.J.

    1992-03-01

    As national and international interests in nuclear arms control and non-proliferation of nuclear weapons, intensify, it becomes ever more important that contributors be aware of the technologies available for the measurement and control of the nuclear materials important to nuclear weapons development. This briefing book presents concise, nontechnical summaries of various special nuclear material (SNM) and tritium production monitoring technologies applicable to the control of nuclear materials and their production. Since the International Atomic Energy Agency (IAEA) operates a multinational, on-site-inspector-based safeguards program in support of the Treaty on the Non-Proliferation of Nuclear Weapons (NPT), many (but not all) of the technologies reported in this document are in routine use or under development for IAEA safeguards.

  2. Quarterly Briefing Book on Environmental and Waste Management Activities

    Energy Technology Data Exchange (ETDEWEB)

    Brown, M.C.

    1991-06-01

    The purpose of the Quarterly Briefing Book on Environmental and Waste Management Activities is to provide managers and senior staff at the US Department of Energy-Richland Operations Office and its contractors with timely and concise information on Hanford Site environmental and waste management activities. Each edition updates the information on the topics in the previous edition, deletes those determined not to be of current interest, and adds new topics to keep up to date with changing environmental and waste management requirements and issues. Section A covers current waste management and environmental restoration issues. In Section B are writeups on national or site-wide environmental and waste management topics. Section C has writeups on program- and waste-specific environmental and waste management topics. Section D provides information on waste sites and inventories on the site. 15 figs., 4 tabs.

  3. Briefing Book for the Zeuthen Workshop, v.1

    CERN Document Server

    CERN. Geneva. Council Strategy Group; Aleksan, Roy; Bertolucci, Sergio; Blondel, A; Cavalli-Sforza, M; Heuer, R D; Linde, Frank L; Mangano, Michelangelo L; Peach, Kenneth J; Rondio, Ewa; Webber, Bryan R; Allanach, Benjamin C; Butterworth, J; Cervera-Villanueva, Anselmo; Davidson, J; De Naurois, Mathieu; Desch, Klaus; Egede, U; Giudice, Gian Francesco; Glover, N; Höcker, A; Huber, P; Jungmann, Klaus; Lombardi, A; Mezzetto, Mauro; Ollitrault, Jean Yves; Onderwater, Gerco; Palanque-Delabrouille, Nathalie; Polosa, Antonio; Raimondi, Pantaleo; Weiglein, Georg; Womersley, John William; Landua, Rolf; Le Goff, J M; Wurr, K

    2006-01-01

    On Jun 18th 2004, the CERN Council, upon the initiative of its President, Prof. Enzo Iarocci, established an ad hoc scientific advisory group (the Strategy Group), to produce a draft strategy for European particle physics, which is to be considered by a special meeting of the CERN Council, to be held in Lisbon on Jul 14th 2006. There are three volumes to the Briefing Book. This first volume contains an introductory essay on particle physics, a summary of the issues discussed at the Open Symposium, and discussions of the other themes that the Strategy should address. The introductory essay on particle physics and the other themes were commissioned by the Preparatory Group. The summary of the issues discussed in the Symposium was prepared by the chairs of the sessions, the session speakers and the scientific secretaries. We acknowledge that this has been a difficult task, again on a very tight timescale, and we would like to thank all of those who have contributed to this volume.

  4. Briefing book on the energy situation in New England

    Energy Technology Data Exchange (ETDEWEB)

    Brainard, J P; Munson, J S; Palmedo, P F

    1976-10-01

    This briefing book is designed to give a concise overview of the facts of the energy situation in New England and of attitudes within the region towards current energy issues. Many of the central problems of U.S. energy policy are manifested in the region in a magnified form. The region entered the period of energy shortages and increasing prices in an economically declining condition. Energy prices were already high in 1970, 30% higher than the rest of the country; the difference increased to 38% by 1974. With essentially no indigenous energy resources, New England is an energy-importing region. For various reasons it is also more dependent on petroleum than other regions of the country and, at the same time, distant from domestic petroleum-producing regions. The result is that over 60% of the fuels it consumes is imported from abroad. Although the future supply of energy to the region is critically dependent on energy-resource policies, policies related for example to coal and oil shale development, the region's concerns cluster around policies and technologies that are perceived to have a more direct impact on its energy welfare. Thus, energy conservation, solar energy, nuclear power, offshore oil development and, in general, the price of energy to the region are paramount issues of concern and debate. Following the Introductory chapter, these issues are discussed in four additional chapters: The Energy Situation in New England; Regional Energy Issues; Energy-Related Institutions; and State Legislation.

  5. Maine State Briefing Book on low-level radioactive waste management

    Energy Technology Data Exchange (ETDEWEB)

    1981-08-01

    The Maine State Briefing Book is one of a series of state briefing books on low-level radioactive waste management practices. It has been prepared to assist state and Federal agency officials in planning for safe low-level radioactive waste disposal. The report contains a profile of low-level radioactive waste generators in Maine. The profile is the result of a survey of radioactive material licensees in Maine. The briefing book also contains a comprehensive assessment of low-level radioactive waste management issues and concerns as defined by all major interested partices including industry, government, the media, and interest groups. The assessment was developed through personal communications with representatives of interested parties, and through a review of media sources. Lastly, the briefing book provides demographic and socioeconomic data and a discussion of relevant goverment agencies and activities, all of which may impact management practices in Maine.

  6. South Dakota State Briefing Book for low-level radioactive waste management

    Energy Technology Data Exchange (ETDEWEB)

    1981-10-01

    The South Dakota State Briefing Book is one of a series of state briefing books on low-level radioactive waste management practices. It has been prepared to assist state and federal agency officials in planning for safe low-level radioactive waste disposal. The report contains a profile of low-level radioactive waste generators in South Dakota. The profile is the result of a survey of NRC licensees in South Dakota. The briefing book also contains a comprehensive assessment of low-level radioactive waste management issues and concerns as defined by all major interested parties including industry, government, the media, and interest groups. The assessment was developed through personal communications with representatives of interested parties, and through a review of media sources. Lastly, the briefing book provides demographic and socioeconomic data and a discussion of relevant government agencies and activities, all of which may impact waste management practices in South Dakota.

  7. Florida State Briefing Book for low-level radioactive-waste management

    Energy Technology Data Exchange (ETDEWEB)

    None

    1981-06-01

    The Florida State Briefing Book is one of a series of state briefing books on low-level radioactive waste management practices. It has been prepared to assist state and federal agency officials in planning for safe low-level radioactive waste disposal. The report contains a profile of low-level radioactive waste generators in Florida. The profile is the result of a survey of NRC licensees in Florida. The briefing book also contains a comprehensive assessment of low-level radioactive waste management issues and concerns as defined by all major interested parties including industry, government, the media, and interest groups. The assessment was developed through personal communications with representatives of interested parties, and through a review of media sources. Lastly, the briefing book provides demographic and socioeconomic data and a discussion of relevant government agencies and activities, all of which may impact waste management practices in Florida.

  8. Kentucky State Briefing Book for low-level radioactive waste management

    Energy Technology Data Exchange (ETDEWEB)

    1981-08-01

    The Kentucky State Briefing Book is one of a series of State briefing books on low-level radioactive waste management practices. It has been prepared to assist State and Federal agency officials in planning for safe low-level radioactive waste disposal. The report contains a profile of low-level radioactive waste generators in Kentucky. The profile is the result of a survey of NRC licensees in Kentucky. The briefing book also contains a comprehensive assessment of low-level radioactive waste management issues and concerns as defined by all major interested parties including industry, government, the media, and interest groups. The assessment was developed through personal communications with representatives of interested parties, and through a review of media sources. Lastly, the briefing book provides demographic and socioeconomic data and a discussion of relevant government agencies and activities, all of which may impact waste management practices in Kentucky.

  9. Washington State Briefing Book for low-level radioactive waste management

    Energy Technology Data Exchange (ETDEWEB)

    1980-12-01

    The Washington State Briefing Book is one of a series of state briefing books on low-level radioactive waste management practices. It has been prepared to assist state and federal agency officials in planning for safe low-level radioactive waste disposal. The report contains a profile of low-level radioactive waste generators in Washington. The profile is the result of a survey of NRC licensees in Washington. The briefing book also contains a comprehensive assessment of low-level radioactive waste management issues and concerns as defined by all major interested parties including industry, government, the media, and interest groups. The assessment was developed through personal communications with representatives of interested parties, and through a review of media sources. Lastly, the briefing book provides demographic and socioeconomic data and a discussion of relevant government agencies and activities, all of which may impact waste management practices in Washington.

  10. Rhode Island State Briefing Book on low-level radioactive-waste management

    Energy Technology Data Exchange (ETDEWEB)

    1981-07-01

    The Rhode Island State Briefing Book is one of a series of state briefing books on low-level radioactive waste management practices. It has been prepared to assist state and federal agency officials in planning for safe low-level radioactive waste disposal. The report contains a profile of low-level radioactive waste generators in Rhode Island. The profile is the result of a survey of radioactive material licensees in Rhode Island. The briefing book also contains a comprehensive assessment of low-level radioactive waste management issues and concerns as defined by all major interested parties including industry, government, the media, and interest groups. The assessment was developed through personal communications with representatives of interested parties, and through a review of media sources. Lastly, the briefing book provides demographic and socioeconomic data and a discussion of relevant government agencies and activities, all of which may affect waste management practices in Rhode Island.

  11. Oregon State Briefing Book for low-level radioactive waste management

    Energy Technology Data Exchange (ETDEWEB)

    1980-12-01

    The Oregon State Briefing Book is one of a series of state briefing books on low-level radioactive waste management practices. It has been prepared to assist state and federal agency officials in planning for safe low-level radioactive waste disposal. The report contains a profile of low-level radioactive waste generators in Oregon. The profile is a result of a survey of NRC licensees in Oregon. The briefing book also contains a comprehensive assessment of low-level radioactive waste management issues and concerns as defined by all major interested parties including industry, government, the media, and interest groups. The assessment was developed through personal communications with representatives of interested parties, and through a review of media sources. Lastly, the briefing book provides demographic and socioeconomic data and a discussion of relevant government agencies and activities, all of which may impact waste management practices in Oregon.

  12. North Carolina State Briefing Book for low-level radioactive waste management

    Energy Technology Data Exchange (ETDEWEB)

    1981-08-01

    The North Carolina State Briefing Book is one of a series of state briefing books on low-level radioactive waste management practices. It has been prepared to assist state and federal agency officials in planning for safe low-level radioactive waste disposal. The report contains a profile of low-level radioactive waste generators in North Carolina. The profile is the result of a survey of NRC licensees in North Carolina. The briefing book also contains a comprehensive assessment of low-level radioactive waste management issues and concerns as defined by all major interested parties including industry, government, the media, and interest groups. The assessment was developed through personal communications with representatives of interested parties, and through a review of media sources. Lastly, the briefing book provides demographic and socioeconomic data and a discussion of relevant government agencies and activities, all of which may impact waste management practices in North Carolina.

  13. Utah State Briefing Book for low-level radioactive waste management

    Energy Technology Data Exchange (ETDEWEB)

    1981-10-01

    The Utah State Briefing Book is one of a series of state briefing books on low-level radioactive waste management practices. It has been prepared to assist state and federal agency officials in planning for safe low-level radioactive waste disposal. The report contains a profile of low-level radioactive waste generators in Utah. The profile is the result of a survey of NRC licensees in Utah. The briefing book also contains a comprehensive assessment of low-level radioactive waste management issues and concerns as defined by all major interested parties including industry, government, the media, and interest groups. The assessment was developed through personal communications with representatives of interested parties, and through a review of media sources. Lastly, the briefing book provides demographic and socioeconomic data and a discussion of relevant government agencies and activities, all of which may impact waste management practices in Utah.

  14. South Carolina State Briefing Book for low-level radioactive waste management

    Energy Technology Data Exchange (ETDEWEB)

    1981-08-01

    The South Carolina State Briefing Book is one of a series of state briefing books on low-level radioactive waste management practices. It has been prepared to assist state and federal agency officials in planning for safe low-level radioactive waste disposal. The report contains a profile of low-level radioactive waste generators in South Carolina. The profile is the result of a survey of NRC licensees in South Carolina. The briefing book also contains a comprehensive assessment of low-level radioactive waste management issues and concerns as definied by all major interested parties including industry, government, the media, and interest groups. The assessment was developed through personal communications with representatives of interested parties, and through a review of media sources. Lastly, the briefing book provides demographic and socioeconomic data and a discussion of relevant government agencies and activities, all of which may impact waste management practices in South Carolina.

  15. Texas State Briefing Book for low-level radioactive waste management

    Energy Technology Data Exchange (ETDEWEB)

    1981-08-01

    The Texas State Briefing Book is one of a series of state briefing books on low-level radioactivee waste management practices. It has been prepared to assist state and federal agency officials in planning for safe low-level radioactive waste disposal. The report contains a profile of low-level radioactive waste generators in Texas. The profile is the result of a survey of NRC licensees in Texas. The briefing book also contains a comprehensive assessment of low-level radioactive waste management issues and concerns as defined by all major interested parties including industry, government, the media, and interest groups. The assessment was developed through personal communications with representatives of interested parties, and through a review of media sources. Lastly, the briefing book provides demographic and socioeconomic data and a discussion of relevant government agencies and activities, all of which may impact waste management practices in Texas.

  16. New Jersey State Briefing Book for low-level radioactive waste management

    Energy Technology Data Exchange (ETDEWEB)

    1981-04-01

    The New Jersey state Briefing Book is one of a series of State briefing books on low-level radioactive waste management practices. It has been prepared to assist state and federal agency officials in planning for safe low-level radioactive waste disposal. The report contains a profile of low-level radioactive waste generators in New Jersey. The profile is the result of a survey of NRC licensees in New Jersey. The briefing book also contains a comprehensive assessment of low-level radioactive waste management issues and concerns as defined by all major interested parties including industry, government, the media, and interest groups. The assessment was developed through personal communications with representatives of interested parties, and through a review of media sources. Lastly, the briefing book provides demographic and socioeconomic data and a discussion of relevant government agencies and activities, all of which may impact waste management practices in New Jersey.

  17. Tennessee State Briefing Book for low-level radioactive waste management

    Energy Technology Data Exchange (ETDEWEB)

    1981-08-01

    The Tennessee State Briefing Book is one of a series of state briefing books on low-level radioactive waste management practices. It has been prepared to assist state and federal agency officials in planning for safe low-level radioactive waste disposal. The report contains a profile of low-level radioactive waste generators in Tennessee. The profile is the result of a survey of NRC licensees in Tennessee. The briefing book also contains a comprehensive assessment of low-level radioactive waste management issues and concerns as defined by all major interested parties including industry, government, the media, and interest groups. The assessment was developed through personal communications with representatives of interested parties, and through a review of media sources. Lastly, the briefing book provides demographic and socioeconomic data and a discussion of relevant government agencies and activities, all of which may impact waste management practices in Tennessee.

  18. Ohio State Briefing Book for low-level radioactive waste management

    Energy Technology Data Exchange (ETDEWEB)

    1981-04-01

    The Ohio State Briefing Book is one of a series of state briefing books on low-level radioactive waste management practices. It has been prepared to assist state and federal agency officials in planning for safe low-level radioactive waste disposal. The report contains a profile of low-level radioactive waste generators in Ohio. The profile is the result of a survey of NRC licensees in Ohio. The briefing book also contains a comprehensive assessment of low-level radioactive waste management issues and concerns as defined by all major interested parties including industry, government, the media, and interest groups. The assessment was developed through personal communications with representatives of interested parties, and through a review of media sources. Lastly, the briefing book provides demographic and socioeconomic data and a discussion of relevant government agencies and activities, all of which may impact waste management practices in Ohio.

  19. Wyoming State Briefing Book for low-level radioactive waste management

    Energy Technology Data Exchange (ETDEWEB)

    1981-10-01

    The Wyoming State Briefing Book is one of a series of state briefing books on low-level radioactive waste management practices. It has been prepared to assist state and federal agency officials in planning for safe low-level radioactive waste disposal. The report contains a profile of low-level radioactive waste generators in Wyoming. The profile is the result of a survey of NRC licensees in Wyoming. The briefing book also contains a comprehensive assessment of low-level radioactive waste management issues and concerns as defined by all major interested parties including industry, government, the media, and interest groups. The assessment was developed through personal communications with representatives of interested parties, and through a review of media sources. Lastly, the briefing book provides demographic and socioeconomic data and a discussion of relevant government agencies and activities, all of which may impact waste management practices in Wyoming.

  20. Mississippi State Briefing Book for low-level radioactive waste management

    Energy Technology Data Exchange (ETDEWEB)

    None

    1981-08-01

    The Mississippi State Briefing Book is one of a series of state briefing books on low-level radioactive waste management practices. It has been prepared to assist state an federal agency officials in planning for safe low-level radioactive waste disposal. The report contains a profile of low-level radioactive waste generators in Mississippi. The profile is the result of a survey of NRC licensees in Mississippi. The briefing book also contains a comprehensive assessment of low-level radioactive waste management issues and concerns as defined by all major interested parties including industry, government, the media, and interest groups. The assessment was developed through personal communications with representatives of interested parties, and through a review of media sources. Lastly, the briefing book provides demographic and socioeconomic data and a discussion of relevant government agencies and activities, all of which may impact waste management practices in Mississippi.

  1. Rhode Island State Briefing Book on low-level radioactive-waste management

    Energy Technology Data Exchange (ETDEWEB)

    1981-07-01

    The Rhode Island State Briefing Book is one of a series of state briefing books on low-level radioactive waste management practices. It has been prepared to assist state and federal agency officials in planning for safe low-level radioactive waste disposal. The report contains a profile of low-level radioactive waste generators in Rhode Island. The profile is the result of a survey of radioactive material licensees in Rhode Island. The briefing book also contains a comprehensive assessment of low-level radioactive waste management issues and concerns as defined by all major interested parties including industry, government, the media, and interest groups. The assessment was developed through personal communications with representatives of interested parties, and through a review of media sources. Lastly, the briefing book provides demographic and socioeconomic data and a discussion of relevant government agencies and activities, all of which may affect waste management practices in Rhode Island.

  2. Massachusetts State Briefing Book for low-level radioactive waste management

    Energy Technology Data Exchange (ETDEWEB)

    1981-03-12

    The Massachusetts State Briefing Book is one of a series of State briefing books on low-level radioactive waste management practices. It has been prepared to assist State and Federal agency officials in planning for safe low-level radioactive waste disposal. The report contains a profile of low-level radioactive waste generators in Massachusetts. The profile is the result of a survey of NRC licensees in Massachusetts. The briefing book also contains a comprehensive assessment of low-level radioactive waste management issues and concerns as defined by all major interested parties including industry, government, the media, and interest groups. The assessment was developed through personal communications with representatives of interested parties, and through a review of media sources. Lastly, the briefing book provides demographic and socioeconomic data and a discussion of relevant government agencies and activities, all of which may impact waste management practices in Massachusetts.

  3. Vermont State Briefing Book on low-level radioactive waste management

    Energy Technology Data Exchange (ETDEWEB)

    1981-07-01

    The Vermont State Briefing Book is one of a series of state briefing books on low-level radioactive waste management practices. It has been prepared to assist state and federal agency officials in planning for safe low-level radioactive waste disposal. The report contains a profile of low-level radioactive waste generators in Vermont. The profile is the result of a survey of Nuclear Regulatory Commission licensees in Vermont. The briefing book also contains a comprehensive assessment of low-level radioactive waste management issues and concerns as defined by all major interested parties including industry, government, the media, and interest groups. The assessment was developed through personal communications with representatives of interested parties, and through a review of media sources. Lastly, the briefing book provides demographic and socioeconomic data and a discussion of relevant government agencies and activities, all of which may affect waste management practices in Vermont.

  4. Pennsylvania State Briefing Book for low-level radioactive waste management

    Energy Technology Data Exchange (ETDEWEB)

    1981-04-01

    The Pennsylvania State Briefing Book is one of a series of state briefing books on low-level radioactive waste management practices. It has been prepared to assist state and federal agency officials in planning for safe low-level radioactive waste disposal. The report contains a profile of low-level radioactive waste generators in Pennsylvania. The profile is the result of a survey of NRC licensees in Pennsylvania. The briefing book also contains a comprehensive assessment of low-level radioactive waste management issues and concerns as defined by all major interested parties including industry, government, the media, and interest groups. The assessment was developed through personal communications with representatives of interested parties, and through a review of media sources. Lastly, the briefing book provides demographic and socioeconomic data and a discussion of relevant government agencies and activities, all of which may impact waste management practices in Pennsylvania.

  5. Puerto Rico State Briefing Book for low-level radioactive waste management

    Energy Technology Data Exchange (ETDEWEB)

    1981-10-01

    The Puerto Rico State Briefing Book is one of a series of state briefing books on low-level radioactive waste management practices. It has been prepared to assist state and federal agency officials in planning for safe low-level radioactive waste disposal. The report contains a profile of low-level radioactive waste generators in Puerto Rico. The profile is the result of a survey of NRC licensees in Puerto Rico. The briefing book also contains a comprehensive assessment of low-level radioactive waste management issues and concerns as defined by all major interested parties including industry, government, the media, and interest groups. The assessment was developed through personal communications with representatives of interested parties, and through a review of media sources. Lastly, the briefing book provides demographic and socioeconomic data and a discussion of relevant government agencies and activities, all of which may impact waste management practices in Puerto Rico.

  6. Wisconsin State Briefing Book for low-level radioactive waste management

    Energy Technology Data Exchange (ETDEWEB)

    1980-11-01

    The Wisconsin State Briefing Book is one of a series of state briefing books on low-level radioactive waste management practices. It has been prepared to assist state and federal agency officials in planning for safe low-level radioactive waste disposal. The report contains a profile of low-level radioactive waste generators in Wisconsin. The profile is the result of a survey of NRC licensees in Wisconsin. The briefing book also contains a comprehensive assessment of low-level radioactive waste management issues and concerns as defined by all major interested parties including industry, government, the media, and interest groups. The assessment was developed through personal communications with representatives of interested parties, and through a review of media sources. Lastly, the briefing book provides demographic and socioeconomic data and a discussion of relevant government agencies and activities, all of which may impact waste management practices in Wisconsin.

  7. North Dakota State Briefing Book for low-level radioactive waste management

    Energy Technology Data Exchange (ETDEWEB)

    None

    1981-10-01

    The North Dakota State Briefing Book is one of a series of state briefing books on low-level radioactive waste management practices. It has been prepared to assist state and federal agency officials in planning for safe low-level radioactive waste disposal. The report contains a profile of low-level radioactive waste generators in North Dakota. The profile is the result of a survey of NRC licensees in North Dakota. The briefing book also contains a comprehensive assessment of low-level radioactive waste management issues and concerns as defined by all major interested parties including industry, government, the media, and interest groups. The assessment was developed through personal communications with representatives of interested parties, and through a review of media sources. Lastly, the briefing book provides demographic and socioeconomic data and a discussion of relevant government agencies and activities, all of which may impact waste management practices in North Dakota.

  8. Connecticut State Briefing Book for low-level radioactive-waste management

    Energy Technology Data Exchange (ETDEWEB)

    None

    1981-06-01

    The Connecticut State Briefing Book is one of a series of state briefing books on low-level radioactive waste management practices. It has been prepared to assist state and federal agency officials in planning for safe low-level radioactive waste disposal. The report contains a profile of low-level radioactive waste generators in Connecticut. The profile is the result of a survey of Nuclear Regulatory Commission licensees in Connecticut. The briefing book also contains a comprehensive assessment of low-level radioactive waste management issues and concerns as defined by all major interested parties including industry, government, the media, and interest groups. The assessment was developed through personal communications with representatives of interested parties, and through a review of media sources. Lastly, the briefing book provides demographic and socioeconomic data and a discussion of relevant government agencies and activities, all of which may affect waste management practices in Connecticut.

  9. Towards the european strategy for particle physics : The briefing book

    NARCIS (Netherlands)

    Akesson, T.; Aleksan, R.; Allanach, B.; Bertolucci, S.; Blondel, A.; Butterworth, J.; Cavalli-Sforza, M.; Cervera, A.; de Naurois, M.; Desch, K.; Egede, U.; Heuer, R.; Hoecker, A.; Huber, P.; Jungmann, K.; Linde, F.; Lombardi, A.; Mangano, M.; Mezzetto, M.; Onderwater, G.; Palanque-Delabrouille, N.; Peach, K.; Polosa, A.; Rondio, E.; Webber, B.; Weiglein, G.; Womersley, J.

    2007-01-01

    This document was prepared as part of the briefing material for the Workshop of the CERN Council Strategy Group, held in DESY Zeuthen from 2nd to 6th May 2006. It gives an overview of the physics issues and of the technological challenges that will shape the future of the field, and incorporates mat

  10. GBM Accreting Pulsar Histories

    Data.gov (United States)

    National Aeronautics and Space Administration — For each source we plot the history of pulse frequency and pulsed flux measured using the Fermi Gamma-Ray Burst Monitor (GBM) NaI detectors. For these measurements...

  11. GBM Spectral Analysis

    Data.gov (United States)

    National Aeronautics and Space Administration — For GBM, input is daily or trigger CSPEC or CTIME file from Fermi archive and corresponding response file from our archive. For LAT, input is daily spectrum file and...

  12. Towards the European strategy for particle physics: The briefing book

    Energy Technology Data Exchange (ETDEWEB)

    Aakesson, T. [Lund University, Lund (Sweden); Aleksan, R. [CPPM/IN2P3-CNRS and DAPNIA/CEA, Marseille (France); Allanach, B.; Webber, B. [Cambridge University and DAMTP, Cambridge (United Kingdom); Bertolucci, S. [INFN and Laboratori Nazionali di Frascati, Frascati (Italy); Blondel, A. [University of Geneva, Geneva (Switzerland); Butterworth, J. [University College London, London (United Kingdom); Cavalli-Sforza, M. [IFAE, Universitat Autonoma de Barcelona, Barcelona (Spain); Cervera, A. [University of Valencia, Valencia (Spain); Naurois, M. de [LPNHE-IN2P3-CNRS and University of Paris VI and VII, Paris (France); Desch, K. [Freiburg University, Freiburg (Germany); Egede, U. [Imperial College London, London (United Kingdom); Heuer, R. [University of Hamburg and DESY, Hamburg (Germany); Hoecker, A.; Lombardi, A.; Mangano, M. [CERN, Geneva 23 (Switzerland); Huber, P. [University of Wisconsin, Madison (United States); Jungmann, K.; Onderwater, G. [KVI, Groningen (Netherlands); Linde, F. [NIKHEF, Amsterdam (Netherlands); Mezzetto, M. [INFN and University of Padova, Padova (Italy); Palanque-Delabrouille, N. [DAPNIA, Saclay (France); Peach, K. [University of Oxford and Royal Holloway University of London, John Adams Institute, London (United Kingdom); Polosa, A. [University of Rome, La Sapienza (Italy); Rondio, E. [Soltan Institute for Nuclear Studies, Warsaw (Poland); Weiglein, G. [Durham University, IPPP, Durham (United Kingdom)

    2007-07-15

    This document was prepared as part of the briefing material for the Workshop of the CERN Council Strategy Group, held in DESY Zeuthen from 2nd to 6th May 2006. It gives an overview of the physics issues and of the technological challenges that will shape the future of the field, and incorporates material presented and discussed during the Symposium on the European Strategy for Particle Physics, held in Orsay from 30th January to 2nd February 2006, reflecting the various opinions of the European community as recorded in written submissions to the Strategy Group and in the discussions at the Symposium. (orig.)

  13. Towards the European strategy for particle physics the Briefing Book

    CERN Document Server

    Åkesson, T; Allanach, Benjamin C; Bertolucci, S; Blondel, A; Butterworth, J; Cavalli-Sforza, M; Cervera-Villanueva, Anselmo; Davidson, S; De Naurois, Mathieu; Desch, K; Egede, U; Glover, N; Heuer, R D; Huber, P; Höcker, A; Jungmann, K; Landua, Rolf; Le Goff, J M; Linde, Frank L; Lombardi, A; Mangano, Michelangelo L; Mezzetto, M; Onderwater, G; Palanque-Delabrouille, Nathalie; Peach, Kenneth J; Polosa, A; Rondio, E; Webber, Bryan R; Weiglein, G; Womersley, J; Wurr, K

    2007-01-01

    This document was prepared as part of the briefing material for the Workshop of the CERN Council Strategy Group, held in DESY Zeuthen from 2nd to 6th May 2006. It gives an overview of the physics issues and of the technological challenges that will shape the future of the field, and incorporates material presented and discussed during the Symposium on the European Strategy for Particle Physics, held in Orsay from 30th January to 2nd February 2006, reflecting the various opinions of the European community as recorded in written submissions to the Strategy Group and in the discussions at the Symposium.

  14. GBM Response Matrix FITS Files

    Data.gov (United States)

    National Aeronautics and Space Administration — Time-dependent detector response matrices for each GBM detector covering the duration of every GBM flare. Needed in the spectral analysis software to relate observed...

  15. FERMIGTRIG - Fermi GBM Trigger Catalog

    Data.gov (United States)

    National Aeronautics and Space Administration — This table lists all of the triggers observed by one or more of the 14 GBM detectors (12 NaI and 2 BGO). Note that there are two Browse catalogs resulting from GBM...

  16. Reviews DVD: Nuclear Radiation Books: The Theoretical Minimum and Time Reborn Equipment: Cobra4 Data Logger Book: Stuff Matters Book: Hunting the Higgs Book: My Brief History Apps Web Watch

    Science.gov (United States)

    2014-01-01

    WE RECOMMEND Nuclear Radiation DVD is an excellent introduction to nuclear radiation WORTH A LOOK The Theoretical Minimum and Time Reborn Can mathematics be the key to reality? Cobra4 Data Logger Apparatus provides an extensive collection of sensors Stuff Matters Materials book deserves a wide readership Hunting the Higgs Higgs book a bit light on detail but good for visits to CERN My Brief History Hawking's book is readable but inconclusive APPS Using apps to help students visualize fields WEB WATCH Vintage film of Eric Laithwaite ... induction hobs as an example of electromagnetic induction ... the deconstruction of a CRO tube ... the Brocken spectre ... the Square Kilometre Array telescope

  17. Briefing Book for the Zeuthen Workshop, v.3 Working Group Instruments and Templates

    CERN Document Server

    CERN. Geneva. Council Strategy Group; Aleksan, Roy; Bertolucci, Sergio; Blondel, A; Cavalli-Sforza, M; Heuer, R D; Linde, Frank L; Mangano, Michelangelo L; Peach, Kenneth J; Rondio, Ewa; Webber, Bryan R

    2006-01-01

    On Jun 18th 2004, the CERN Council, upon the initiative of its President, Prof. Enzo Iarocci, established an ad hoc scientific advisory group (the Strategy Group), to produce a draft strategy for European particle physics, which is to be considered by a special meeting of the CERN Council, to be held in Lisbon on Jul 14th 2006. There are three volumes to the Briefing Book. This, the third volume, has the templates and other instruments that will be needed to help the debate. It contains the detailed agenda for the Zeuthen workshop, a briefing on the objectives for each of the items on the agenda, a standardised vocabulary to be used to describe the initiatives, a detailed list of the working groups and the themes that they should address, and the allocation of members of the Strategy Group to the working groups.

  18. Briefing Book, Interagency Geothermal Coordinating Council (IGCC) Meeting of April 28, 1988

    Energy Technology Data Exchange (ETDEWEB)

    None

    1988-04-28

    The IGCC of the U.S. government was created under the intent of Public Law 93-410 (1974) to serve as a forum for the discussion of Federal plans, activities, and policies that are related to or impact on geothermal energy. Eight Federal Departments were represented on the IGCC at the time of this meeting. The main presentations in this report were on: Department of Energy Geothermal R&D Program, the Ormat binary power plant at East Mesa, CA, Potential for direct use of geothermal at Defense bases in U.S. and overseas, Department of Defense Geothermal Program at China Lake, and Status of the U.S. Geothermal Industry. The IGCC briefing books and minutes provide a historical snapshot of what development and impact issues were important at various time. (DJE 2005)

  19. The GLAST Burst Monitor (GBM)

    OpenAIRE

    Lichti, G. G.; Briggs, M.S.; Diehl, R.; Fishman, G.; Georgii, R.; Kippen, R. M.; Kouveliotou, C.; Meegan, C.; Paciesas, W.; Preece, R.; Schoenfelder, V.; von Kienlin, A.

    2001-01-01

    The selection of the GLAST burst monitor (GBM) by NASA will allow the investigation of the relation between the keV and the MeV-GeV emission from gamma-ray bursts. The GBM consists of 12 NaI and 2 BGO crystals allowing a continuous measurement of the energy spectra of gamma-ray bursts from ~5 keV to \\~30 MeV. One feature of the GBM is its high time resolution for time-resolved gamma-ray spectroscopy. Moreover the arrangement of the NaI crystals allows a rapid on-board location (

  20. The question of the existence of God in the book of Stephen Hawking: A brief history of time

    NARCIS (Netherlands)

    Driessen, A.; Driessen, A; Suarez, A.

    1997-01-01

    The continuing interest in the book of S. Hawking "A Brief History of Time" makes a philosophical evaluation of the content highly desirable. As will be shown, the genre of this work can be identified as a speciality in philosophy, namely the proof of the existence of God. In this study an attempt

  1. Briefing Book for the Zeuthen Workshop, v.2 Input received from the particle physics community, funding agencies, and other resources

    CERN Document Server

    CERN. Geneva. Council Strategy Group; Aleksan, Roy; Bertolucci, Sergio; Blondel, A; Cavalli-Sforza, M; Heuer, R D; Linde, Frank L; Mangano, Michelangelo L; Peach, Kenneth J; Rondio, Ewa; Webber, Bryan R

    2006-01-01

    On Jun 18th 2004, the CERN Council, upon the initiative of its President, Prof. Enzo Iarocci, established an ad hoc scientific advisory group (the Strategy Group), to produce a draft strategy for European particle physics, which is to be considered by a special meeting of the CERN Council, to be held in Lisbon on Jul 14th 2006. There are three volumes to the Briefing Book. This second volume contains input that the Preparatory Group has received. The structure of this volume of the Briefing Book is summarised here. In the following chapter we collect the documents received as input to the Strategy Group from individual scientists, collaborations, working groups, etc. Most of these documents were submitted before the Orsay Open Symposium, and contributed to the material presented by the Symposium speakers, and to the ensuing discussions. They are reproduced here unedited, and grouped by topic following the chapter subdivision of Briefing Book 1, Part 1. Chapter 3 presents contributions received from national s...

  2. FERMIGBRST - Fermi GBM Burst Catalog

    Data.gov (United States)

    National Aeronautics and Space Administration — This table lists all of the triggers observed by a subset of the 14 GBM detectors (12 NaI and 2 BGO) which have been classified as gamma-ray bursts (GRBs). Note that...

  3. Books

    Science.gov (United States)

    White, Daniel O.

    1973-01-01

    Reviews books and curriculum materials for law-related courses for public schools coordinated by the National Center for Law-Focused Education in Chicago. Police and police behavior is the focus of this review. (DM)

  4. Dissenting view. A Brief, Liberal, Catholic Defense of Abortion [by] Daniel A. Dombrowski and Robert Deltete. Book review.

    Science.gov (United States)

    Padovano, A T

    2000-01-01

    This paper reviews the book "A Brief, Liberal, Catholic Defense of Abortion", by Daniel A. Dombrowski and Robert Deltete. In this book, the authors argue that the Catholic tradition on abortion is very different from the present teaching of the Catholic Church. The issue of abortion is explored in the book through two different philosophies and two major Catholic theologians. The two philosophies are the perversity of sex (abortion distorts sex) and the ontological (the fetus as a person) philosophies. Saint Augustine primarily identified with the perversity of sex and viewed early and late stages of abortion as evil, because it destroys the conceptus, which is the only justification for sex and because human life is present--after sensation and quickening occur. On the other hand, Saint Thomas Aquinas with the ontological approach was less interested in abortion, rather developed hylomorphism. He stated that there is no human life in the womb until the 5th or 6th month, but rather a cluster of cells; thus God cannot infuse a soul into a small cluster of cells since body and soul belong together. The authors believe that this book is a model of reasoned discourse about abortion issues and is proves to be beneficial to a Catholic as well as any thoughtful person.

  5. Sustainable Agriculture in Print: Current Books. Special Reference Briefs: SRB 95-02.

    Science.gov (United States)

    National Agricultural Library, Beltsville, MD.

    Prepared by the Alternative Farming Systems Information Center (AFSIC) staff and volunteers, this annotated bibliography provides a list of 85 recently published books pertaining to sustainable agriculture. AFSIC focuses on alternative farming systems (e.g., sustainable, low-input, regenerative, biodynamic, and organic) that maintain agricultural…

  6. Gamma-Ray Astrophysics NSSTC Fermi GBM

    Data.gov (United States)

    National Aeronautics and Space Administration — The Fermi Gamma-Ray Burst Monitor (GBM) is not a pointed or imaging instrument. To determine fluxes for known sources, we measure the change in the count rate...

  7. Magnetar Observations with Fermi/GBM

    Science.gov (United States)

    Kouveliotou, Chryssa

    2009-01-01

    NASA's Fermi Observatory was launched June 11, 2009; the Fermi Gamma Ray Burst Monitor (GBM) began normal operations on July 14, about a month after launch, when the trigger algorithms were enabled. In the first year of operations we recorded emission from four magnetar sources; of these, only one was an old magnetar: SGR 1806+20. The other three detections were: SGR J0501+4516, newly discovered with Swift and extensively monitored with both Swift and GBM, SGR J1550-5418, a source originally classified as an Anomalous X-ray Pulsar (AXP) and a very recently discovered new source, SGR 0418+5729. I report below on the current status of the analyses efforts of the GBM data.

  8. Anti-GBM Disease in Pregnancy

    Directory of Open Access Journals (Sweden)

    Mohammed Muqeet Adnan MD

    2015-12-01

    Full Text Available Antiglomerular basement membrane (GBM disease presenting during pregnancy is uncommon. We present a case of a pregnant female who presented with acute renal failure requiring dialysis due to anti-GBM disease. She responded well to plasma exchange, high-dose steroids, and hemodialysis. Cyclophosphamide was discussed but not given at the patient’s request due to concerns for the well-being of the fetus. Unfortunately, she suffered a spontaneous abortion in her eighth week of pregnancy. Subsequently, she had progressive improvement in her renal function and became hemodialysis independent at 2 weeks after diagnosis. Her renal function returned to baseline 3 months after diagnosis. We present this case in detail and review the literature regarding anti-GBM disease in pregnancy.

  9. Three years of Transients with Fermi GBM

    Science.gov (United States)

    Wilson-Hodge, Colleen A.

    2012-01-01

    The Gamma-ray Burst Monitor (GBM) is an all-sky monitoring instrument, sensitive between 8 keV and 40 MeV, with a primary objective of supporting the Large Area Telescope (LAT) in observations of Gamma-Ray Bursts (GRBs). Both instruments are part of the Fermi Gamma-ray Space Telescope. Together, the GBM and LAT instruments have provided ground-breaking measurements of GRBs that have, after 10 years of focus on GRB afterglows, inspired renewed interest in the prompt emission phase of GRBs and the physical mechanisms that fuel them. In addition to GRB science, GBM has made significant contributions to the astrophysics of galactic transient sources including long-term variations in the Crab nebula, spin state transitions in accretion powered pulsars, state transitions in black hole X-ray binaries, and unprecedented time-resolved spectral studies of soft gamma-ray repeater bursts. Closer to home, GBM also contributes to solar flare and terrestrial gamma flash science.

  10. TCGA Workshop: Genomics and Biology of Glioblastoma Multiforme (GBM) - TCGA

    Science.gov (United States)

    The National Cancer Institute (NCI) and National Human Genome Research Institute (NHGRI) held a workshop entitled, “Genomics and Biology of Glioblastoma Multiforme (GBM),” to review the initial GBM data from the TCGA pilot project.

  11. The Shrinking Scholarly Book.

    Science.gov (United States)

    Heller, Scott

    1999-01-01

    Economic pressures in the publishing industry are causing faculty to write shorter books. The authors want their books to be readable, and publishers want to reduce costs and make the books affordable for a wider audience, including students. Brief but broad surveys, short introductory primers, quick biographies, and books with very basic themes…

  12. Diagnosis and classification of Goodpasture's disease (anti-GBM).

    Science.gov (United States)

    Hellmark, Thomas; Segelmark, Mårten

    2014-01-01

    Goodpasture's disease or anti-glomerular basement membrane disease (anti-GBM-disease) is included among immune complex small vessel vasculitides. The definition of anti-GBM disease is a vasculitis affecting glomerular capillaries, pulmonary capillaries, or both, with GBM deposition of anti-GBM autoantibodies. The disease is a prototype of autoimmune disease, where the patients develop autoantibodies that bind to the basement membranes and activate the classical pathway of the complement system, which start a neutrophil dependent inflammation. The diagnosis of anti-GBM disease relies on the detection of anti-GBM antibodies in conjunction with glomerulonephritis and/or alveolitis. Overt clinical symptoms are most prominent in the glomeruli where the inflammation usually results in a severe rapidly progressive glomerulonephritis. Despite modern treatment less than one third of the patients survive with a preserved kidney function after 6 months follow-up. Frequencies vary from 0.5 to 1 cases per million inhabitants per year and there is a strong genetic linkage to HLA-DRB1(∗)1501 and DRB1(∗)1502. Essentially, anti-GBM disease is now a preferred term for what was earlier called Goodpasture's syndrome or Goodpasture's disease; anti-GBM disease is now classified as small vessel vasculitis caused by in situ immune complex formation; the diagnosis relies on the detection of anti-GBM in tissues or circulation in conjunction with alveolar or glomerular disease; therapy is effective only when detected at an early stage, making a high degree of awareness necessary to find these rare cases; 20-35% have anti-GBM and MPO-ANCA simultaneously, which necessitates testing for anti-GBM whenever acute test for ANCA is ordered in patients with renal disease. Copyright © 2014 Elsevier Ltd. All rights reserved.

  13. All-Sky Monitoring of Variable Sources with Fermi GBM

    Science.gov (United States)

    Wilson-Hodge, Colleen A.; Cherry, Michael L.; Case, Gary L.; Camero-Arranz, Ascension; Chaplin, Vandiver; Connaughton, Valerie; Finger, Mark H.; Jenke, Pater; Rodi, James C.; Baumgartner, Wayne H.; Beklen, Elif; Bhat, P. Narayana; Briggs, Michael S.; Gehrels, Neil; Greiner, Jochen; Jahoda, Keith; Kippen, R. Marc; Kouveliotou, Chryssa; Krimm, Hans A.; Kuulkers, Erik; Lund, Niels; Meegan, Charles A.; Natalucci, Lorenzo; Paciesas, William S.; Preece, Robert

    2011-01-01

    This slide presentation reviews the monitoring of variable sources with the Fermi Gamma Ray Burst Monitor (GBM). It reviews the use of the Earth Occultation technique, the observations of the Crab Nebula with the GBM, and the comparison with other satellite's observations. The instruments on board the four satellites indicate a decline in the Crab from 2008-2010.

  14. Comparative analyses of gene copy number and mRNA expression in GBM tumors and GBM xenografts

    Energy Technology Data Exchange (ETDEWEB)

    Hodgson, J. Graeme; Yeh, Ru-Fang; Ray, Amrita; Wang, Nicholas J.; Smirnov, Ivan; Yu, Mamie; Hariono, Sujatmi; Silber, Joachim; Feiler, Heidi S.; Gray, Joe W.; Spellman, Paul T.; Vandenberg, Scott R.; Berger, Mitchel S.; James, C. David

    2009-04-03

    Development of model systems that recapitulate the molecular heterogeneity observed among glioblastoma multiforme (GBM) tumors will expedite the testing of targeted molecular therapeutic strategies for GBM treatment. In this study, we profiled DNA copy number and mRNA expression in 21 independent GBM tumor lines maintained as subcutaneous xenografts (GBMX), and compared GBMX molecular signatures to those observed in GBM clinical specimens derived from the Cancer Genome Atlas (TCGA). The predominant copy number signature in both tumor groups was defined by chromosome-7 gain/chromosome-10 loss, a poor-prognosis genetic signature. We also observed, at frequencies similar to that detected in TCGA GBM tumors, genomic amplification and overexpression of known GBM oncogenes, such as EGFR, MDM2, CDK6, and MYCN, and novel genes, including NUP107, SLC35E3, MMP1, MMP13, and DDX1. The transcriptional signature of GBMX tumors, which was stable over multiple subcutaneous passages, was defined by overexpression of genes involved in M phase, DNA replication, and chromosome organization (MRC) and was highly similar to the poor-prognosis mitosis and cell-cycle module (MCM) in GBM. Assessment of gene expression in TCGA-derived GBMs revealed overexpression of MRC cancer genes AURKB, BIRC5, CCNB1, CCNB2, CDC2, CDK2, and FOXM1, which form a transcriptional network important for G2/M progression and/or checkpoint activation. Our study supports propagation of GBM tumors as subcutaneous xenografts as a useful approach for sustaining key molecular characteristics of patient tumors, and highlights therapeutic opportunities conferred by this GBMX tumor panel for testing targeted therapeutic strategies for GBM treatment.

  15. Fully automatic GBM segmentation in the TCGA-GBM dataset: Prognosis and correlation with VASARI features.

    Science.gov (United States)

    Rios Velazquez, Emmanuel; Meier, Raphael; Dunn, William D; Alexander, Brian; Wiest, Roland; Bauer, Stefan; Gutman, David A; Reyes, Mauricio; Aerts, Hugo J W L

    2015-11-18

    Reproducible definition and quantification of imaging biomarkers is essential. We evaluated a fully automatic MR-based segmentation method by comparing it to manually defined sub-volumes by experienced radiologists in the TCGA-GBM dataset, in terms of sub-volume prognosis and association with VASARI features. MRI sets of 109 GBM patients were downloaded from the Cancer Imaging archive. GBM sub-compartments were defined manually and automatically using the Brain Tumor Image Analysis (BraTumIA). Spearman's correlation was used to evaluate the agreement with VASARI features. Prognostic significance was assessed using the C-index. Auto-segmented sub-volumes showed moderate to high agreement with manually delineated volumes (range (r): 0.4 - 0.86). Also, the auto and manual volumes showed similar correlation with VASARI features (auto r = 0.35, 0.43 and 0.36; manual r = 0.17, 0.67, 0.41, for contrast-enhancing, necrosis and edema, respectively). The auto-segmented contrast-enhancing volume and post-contrast abnormal volume showed the highest AUC (0.66, CI: 0.55-0.77 and 0.65, CI: 0.54-0.76), comparable to manually defined volumes (0.64, CI: 0.53-0.75 and 0.63, CI: 0.52-0.74, respectively). BraTumIA and manual tumor sub-compartments showed comparable performance in terms of prognosis and correlation with VASARI features. This method can enable more reproducible definition and quantification of imaging based biomarkers and has potential in high-throughput medical imaging research.

  16. Time-Domain Astronomy with the Fermi GBM

    Science.gov (United States)

    Hui, C. M.

    2017-01-01

    The Fermi Gamma-ray Burst Monitor (GBM) is an all-sky monitoring instrument sensitive to energies from 8 keV to 40 MeV. Over the past 8 years of operation, the GBM has detected over 240 gamma-ray bursts per year and provided timely GCN notices with localization to few-degree accuracy for follow-up observations. In addition to GRBs, Galactic transients, solar flares, and terrestrial gamma-ray flashes have also been observed. In recent years we have also been searching the continuous GBM data for electromagnetic counterpart to astrophysical neutrinos and gravitational wave events, as these are believed to be associated with gamma-ray bursts. With continuous data downlink every few hours and a temporal resolution of 2 microseconds, GBM is well suited for observing transients and supporting EM follow-up in the era of multi-messenger astronomy.

  17. Magnetar Observations in the Swift-Fermi/GBM Era

    Science.gov (United States)

    Kouveliotou, Chryssa

    2010-01-01

    NASA's Fermi Observatory was launched June 11, 2008; the Fermi Gamma Ray Burst Monitor (GBM) began normal operations on July 14, about a month after launch, when the trigger algorithms were enabled. Since then, and against all odds, GBM recorded over 600 bursts from 4 SGRs. Of these four sources, only one was an old magnetar: SGR J1806+20. SGR J0501+4516, was discovered with Swift and extensively monitored with GBM. A source originally classified as AXP 1E1547.0-5408 exhibited SGR-like bursting behavior and we reclassified it as SGR J1550-5418. Finally, GBM discovered SGR J0418+5729 on 2009 June. Finally, on March 2010, a third new magnetar was discovered with Swift, SGR J1833-0832. I report below on the current status of the field and on several results combining multi-satellite and ground-based data

  18. Anti-GBM disease and renal vein thrombosis.

    Science.gov (United States)

    Bailey, Phillippa; Sarfraz, Farook; Ravanan, Rommel

    2011-11-15

    A 23-year-old female who presented with advanced renal failure was subsequently diagnosed with renal vein thrombosis and antiglomerular basement membrane (GBM) antibody disease. A previous case of renal vein thrombosis has been reported in association with anti-GBM disease, but to our knowledge, this is the first reported case in which the presentation of anti-GBM disease and renal vein thrombosis was concurrent. Further study is essential to understand if the association of anti-GBM disease and renal vein thrombosis as seen in our case was pure coincidence or is in fact occurs more frequently. It may be that the dual diagnosis is not made as establishing one sufficient diagnosis for renal failure may halt further investigations for additional diagnoses.

  19. GBM heterogeneity characterization by radiomic analysis of phenotype anatomical planes

    Science.gov (United States)

    Chaddad, Ahmad; Desrosiers, Christian; Toews, Matthew

    2016-03-01

    Glioblastoma multiforme (GBM) is the most common malignant primary tumor of the central nervous system, characterized among other traits by rapid metastatis. Three tissue phenotypes closely associated with GBMs, namely, necrosis (N), contrast enhancement (CE), and edema/invasion (E), exhibit characteristic patterns of texture heterogeneity in magnetic resonance images (MRI). In this study, we propose a novel model to characterize GBM tissue phenotypes using gray level co-occurrence matrices (GLCM) in three anatomical planes. The GLCM encodes local image patches in terms of informative, orientation-invariant texture descriptors, which are used here to sub-classify GBM tissue phenotypes. Experiments demonstrate the model on MRI data of 41 GBM patients, obtained from the cancer genome atlas (TCGA). Intensity-based automatic image registration is applied to align corresponding pairs of fixed T1˗weighted (T1˗WI) post-contrast and fluid attenuated inversion recovery (FLAIR) images. GBM tissue regions are then segmented using the 3D Slicer tool. Texture features are computed from 12 quantifier functions operating on GLCM descriptors, that are generated from MRI intensities within segmented GBM tissue regions. Various classifier models are used to evaluate the effectiveness of texture features for discriminating between GBM phenotypes. Results based on T1-WI scans showed a phenotype classification accuracy of over 88.14%, a sensitivity of 85.37% and a specificity of 96.1%, using the linear discriminant analysis (LDA) classifier. This model has the potential to provide important characteristics of tumors, which can be used for the sub-classification of GBM phenotypes.

  20. Visualizing molecular profiles of glioblastoma with GBM-BioDP.

    Directory of Open Access Journals (Sweden)

    Orieta Celiku

    Full Text Available Validation of clinical biomarkers and response to therapy is a challenging topic in cancer research. An important source of information for virtual validation is the datasets generated from multi-center cancer research projects such as The Cancer Genome Atlas project (TCGA. These data enable investigation of genetic and epigenetic changes responsible for cancer onset and progression, response to cancer therapies, and discovery of the molecular profiles of various cancers. However, these analyses often require bulk download of data and substantial bioinformatics expertise, which can be intimidating for investigators. Here, we report on the development of a new resource available to scientists: a data base called Glioblastoma Bio Discovery Portal (GBM-BioDP. GBM-BioDP is a free web-accessible resource that hosts a subset of the glioblastoma TCGA data and enables an intuitive query and interactive display of the resultant data. This resource provides visualization tools for the exploration of gene, miRNA, and protein expression, differential expression within the subtypes of GBM, and potential associations with clinical outcome, which are useful for virtual biological validation. The tool may also enable generation of hypotheses on how therapies impact GBM molecular profiles, which can help in personalization of treatment for optimal outcome. The resource can be accessed freely at http://gbm-biodp.nci.nih.gov (a tutorial is included.

  1. Data communications pocket book

    CERN Document Server

    Tooley, Michael

    2014-01-01

    Data Communications Pocket Book, Second Edition presents information relevant to data communication. The book provides tabulated reference materials with a brief description and diagrams. The coverage of the text includes abbreviations, terminal control codes, and conversion tables. The text will be of great use to individuals involved in the interconnection of computer systems.

  2. Death, Children, and Books.

    Science.gov (United States)

    Carr, Robin L.

    The books listed in this annotated bibliography are intended to help children understand the reality of death and deal with the mystery and emotions that accompany it. Each entry indicates the genre and reading level of the book and provides a brief description of the attitude toward death that it conveys. The selections include fables, fantasy,…

  3. THE FIVE YEAR FERMI/GBM MAGNETAR BURST CATALOG

    Energy Technology Data Exchange (ETDEWEB)

    Collazzi, A. C. [SciTec, Inc., 100 Wall Street, Princeton, NJ 08540 (United States); Kouveliotou, C.; Horst, A. J. van der; Younes, G. A. [Department of Physics, The George Washington University, 725 21st Street NW, Washington, DC 20052 (United States); Kaneko, Y.; Göğüş, E. [Sabancı University, Orhanlı-Tuzla, İstanbul 34956 (Turkey); Lin, L. [François Arago Centre, APC, 10 rue Alice Domon et Léonie Duquet, F-75205 Paris (France); Granot, J. [Department of Natural Sciences, The Open University of Israel, 1 University Road, P.O. Box 808, Raanana 43537 (Israel); Finger, M. H. [Universities Space Research Association, NSSTC, 320 Sparkman Drive, Huntsville, AL 35805 (United States); Chaplin, V. L. [School of Medicine, Vanderbilt University, 1161 21st Avenue S, Nashville, TN 37232 (United States); Huppenkothen, D. [Center for Data Science, New York University, 726 Broadway, 7th Floor, New York, NY 10003 (United States); Watts, A. L. [Anton Pannekoek Institute, University of Amsterdam, Postbus 94249, 1090 GE Amsterdam (Netherlands); Kienlin, A. von [Max-Planck-Institut für extraterrestrische Physik, Giessenbachstrasse 1, D-85748 Garching (Germany); Baring, M. G. [Department of Physics and Astronomy, Rice University, MS-108, P.O. Box 1892, Houston, TX 77251 (United States); Gruber, D. [Planetarium Südtirol, Gummer 5, I-39053 Karneid (Italy); Bhat, P. N. [CSPAR, University of Alabama in Huntsville, 320 Sparkman Drive, Huntsville, AL 35899 (United States); Gibby, M. H., E-mail: acollazzi@scitec.com [Jacobs Technology, Inc., Huntsville, AL (United States); and others

    2015-05-15

    Since launch in 2008, the Fermi Gamma-ray Burst Monitor (GBM) has detected many hundreds of bursts from magnetar sources. While the vast majority of these bursts have been attributed to several known magnetars, there is also a small sample of magnetar-like bursts of unknown origin. Here, we present the Fermi/GBM magnetar catalog, providing the results of the temporal and spectral analyses of 440 magnetar bursts with high temporal and spectral resolution. This catalog covers the first five years of GBM magnetar observations, from 2008 July to 2013 June. We provide durations, spectral parameters for various models, fluences, and peak fluxes for all the bursts, as well as a detailed temporal analysis for SGR J1550–5418 bursts. Finally, we suggest that some of the bursts of unknown origin are associated with the newly discovered magnetar 3XMM J185246.6+0033.7.

  4. The Real E-books.

    Science.gov (United States)

    Ditlea, Steve

    2000-01-01

    Focuses on the "real" e-books. Discusses Stephen King's novella released exclusively for electronic publication, and discusses experiences of another author writing on a specialized subject. Presents a brief background of e-books. Examines the differences between Portable Document Format (PDF) technology and the new Open eBook (OEB) standard.…

  5. Fermi GBM Observations of LIGO Gravitational Wave event GW150914

    CERN Document Server

    Connaughton, V; Goldstein, A; Briggs, M S; Zhang, B -B; Hui, C M; Jenke, P; Racusin, J; Wilson-Hodge, C A; Bhat, P N; Cleveland, W; Fitzpatrick, G; Giles, M M; Gibby, M H; Greiner, J; von Kienlin, A; Kippen, R M; McBreen, S; Mailyan, B; Meegan, C A; Paciesas, W S; Preece, R D; Roberts, O; Sparke, L; Stanbro, M; Toelge, K; Veres, P; Yu, H -F; authors, other

    2016-01-01

    With an instantaneous view of 70% of the sky, the Fermi Gamma-ray Burst Monitor (GBM) is an excellent partner in the search for electromagnetic counterparts to gravitational wave (GW) events. GBM observations at the time of the Laser Interferometer Gravitational-wave Observatory (LIGO)event GW150914 reveal the presence of a weak transient source above 50 keV, 0.4 s after the GW event was detected, with a false alarm probability of 0.0022. This weak transient lasting 1 s does not appear connected with other previously known astrophysical, solar, terrestrial, or magnetospheric activity. Its localization is ill-constrained but consistent with the direction of GW150914. The duration and spectrum of the transient event suggest it is a weak short Gamma-Ray Burst arriving at a large angle to the direction in which Fermi was pointing, where the GBM detector response is not optimal. If the GBM transient is associated with GW150914, this electromagnetic signal from a stellar mass black hole binary merger is unexpected....

  6. The Five Year Fermi/GBM Magnetar Burst Catalog

    NARCIS (Netherlands)

    A.C. Collazzi; C. Kouveliotou; A.J. van der Horst; G.A. Younes; Y. Kaneko; E. Göğüş; L. Lin; J. Granot; M.H. Finger; V.L. Chaplin; D. Huppenkothen; A.L. Watts; A. von Kienlin; M.G. Baring; D. Gruber; P.N. Bhat; M.H. Gibby; N. Gehrels; J. Mcenery; M. van der Klis; R.A.M.J. Wijers

    2015-01-01

    Since launch in 2008, the Fermi Gamma-ray Burst Monitor (GBM) has detected many hundreds of bursts from magnetar sources. While the vast majority of these bursts have been attributed to several known magnetars, there is also a small sample of magnetar-like bursts of unknown origin. Here, we present

  7. Recruitment of bone marrow derived cells during anti-angiogenic therapy in GBM : Bone marrow derived cell in GBM

    NARCIS (Netherlands)

    Boer, Jennifer C.; Walenkamp, Annemiek M. E.; den Dunnen, Wilfred F. A.

    2014-01-01

    Glioblastoma (GBM) is a highly vascular tumor characterized by rapid and invasive tumor growth, followed by oxygen depletion, hypoxia and neovascularization, which generate a network of disorganized, tortuous and permeable vessels. Recruitment of bone marrow derived cells (BMDC) is crucial for vascu

  8. 《周易》智慧简析%A Brief Analysis on the Wisdom of "Book of Changes"

    Institute of Scientific and Technical Information of China (English)

    于文杰

    2012-01-01

    Book of Changes" is the most ancient cultural books, one of the wonderful work oft.he Oriental culture. Chron- icles scholars from different angles, "Book of Changes", including study and research" Book of Changes" wisdom is one of the important work continuously. "Book of Changes" Wisdom is multifaceted, multi-level, this article attempts to briefly hex- agrams, hexagram and line statements, easy to pass the three areas to explore the wisdom of "Book of Changes ".%《周易》是我国最古老的文化典籍之一,是东方文化之奇葩。历代学者从不同角度研究《周易》,其中学习研究《周易》智慧是其中一项重要连续工作。《周易》智慧是多方面、多层次的,本文试图简单地从卦爻本身、卦爻辞、易大传三方面探讨《周易》智慧。

  9. High-energy transients with Fermi/GBM

    Energy Technology Data Exchange (ETDEWEB)

    Gruber, David

    2012-10-09

    For most of mankind's history, astronomy was performed on-ground in the optical energy range. It was only when space-based missions, built more than 50 years ago, detected photons with mind-boggling energies that the exploration of the violent Universe really began. These {gamma}-ray photons still provide us with an unprecedented wealth of information for the most energetic processes taking place in the cosmos. Faithful to the olympic slogan ''higher, faster, further'', an increasing armada of {gamma}-ray satellites was built and launched over the last couple of decades with Fermi being the youngest of its kind. In this thesis, I use data from the Gamma-Ray Burst Monitor (GBM) onboard the Fermi satellite. The focus of this work lies on three very different classes of high-energy astrophysical transients: Gamma-Ray Bursts (GRBs), solar flares and Soft Gamma Repeaters (SGRs). In Chapter 2, I present GRB 091024A, a burst of very long duration in {gamma}-rays where optical data could be acquired well during its active phase. The optical light curve shows very intriguing features which I subsequently interpret as the so called ''optical flash'', a fundamental property of the ''fireball'' model. Although predicted by the latter model, only a handful of GRBs show such a behavior, making them interesting transients to study. Furthermore, I present the fundamental temporal and spectral properties of 47 GBM-detected GRBs with known redshifts. As GRBs explode at cosmological distances it is of uttermost importance to study them in their restframe to get a better understanding of their emission mechanisms. I confirm several correlations already found in the past together with an intriguing connection between redshift and the peak energy (E{sub peak}) of GRBs. Although this correlation is heavily influenced by instrumental effects, it is not unexpected from other experimental results, giving it more credibility

  10. Book Review: Book review

    Science.gov (United States)

    Manohar, C. S.

    2015-02-01

    The subject of the theory of vibrations has carried an aesthetic appeal to generations of engineering students for its richness of ideas, and for the intellectual challenges it offers. Also, the diverse range of its applications (covering civil, mechanical, automotive, and aerospace structures) has provided obvious motivations for its study. For most students, the subject provides, perhaps, the first encounter in substantial application of mathematical tools (differential equations, calculus of variations, Fourier/Laplace transforms, and matrix algebra) to engineering problems. The intimate relationship that the subject of mechanics has with mathematics strikes home probably for the first time. While teaching this subject, the instructor is spoilt for choice in selecting a text book and so are the students who wish to pursue a self-study of the subject. Many luminaries in the field have offered their own exposition of the subject: starting from the classics of Rayleigh, Timoshenko, Den Hartog, Bishop and Johnson, and the works of more recent vintage (e.g., the books by Meirovich, Clough, and Penzien, and works with computational flavour, such as, those by Bathe and Petyt), several works easily come to one's mind. Given this milieu, it requires a distinctive conviction to write a new book on this subject. And, here we have a book, written by a practitioner, which aims to deal with fundamental aspects of vibrations of engineering systems. The scepticism that this reviewer had on the need for having one more such book vanished as he browsed through the book and read selectively a few sections. The author's gift for elegant explanations is immediately noticeable even in such a preliminary reading. After a more careful reading, the reviewer has found this book to be insightful and he considers the book to be a welcome addition to the family of books on vibration engineering. The author has struck a fine balance between physical explanations, mathematical niceties

  11. The Interplanetary Network Supplement to the Fermi GBM Catalog - An AO-2 and AO-3 Guest Investigator Project

    Science.gov (United States)

    Hurley, K.; Briggs, M.; Connaughton, V.; Meegan, C.; von Kienlin, A.; Rau, A.; Zhang, X.; Golenetskii, S.; Aptekar, R.; Mazets, E.; Pal'shin, V.; Fredericks, D.; Barthelmy, S.; Cummings, J.; Gehrels, N.; Krimm, H. A.; Mitrofanov, I. G.; Golovin, D.; Litvak, M. L.; Sanin, A. B.; Boynton, W.; Fellows, C.; Harshman, K.; Starr, R.; Goldsten, J.

    2012-01-01

    In the first two years of operation of the Fermi GBM, the 9-spacecraft Interplanetary Network (IPN) detected 158 GBM bursts with one or two distant spacecraft, and triangulated them to annuli or error boxes. Combining the IPN and GBM localizations leads to error boxes which are up to 4 orders of magnitude smaller than those of the GBM alone. These localizations comprise the IPN supplement to the GBM catalog, and they support a wide range of scientific investigations.

  12. The Interplanetary Network Supplement to the Fermi GBM Catalog - An AO-2 and AO-3 Guest Investigator Project

    CERN Document Server

    Hurley, K; Connaughton, V; Meegan, C; von Kienlin, A; Rau, A; Zhang, X; Golenetskii, S; Aptekar, R; Mazets, E; Pal'shin, V; Frederiks, D; Barthelmy, S; Cline, T; Cummings, J; Gehrels, N; Krimm, H A; Mitrofanov, I G; Golovin, D; Litvak, M L; Sanin, A B; Boynton, W; Fellows, C; Harshman, K; Starr, R; Smith, D M; Hajdas, W; Yamaoka, K; Ohno, M; Fukazawa, Y; Takahashi, T; Tashiro, M; Terada, Y; Murakami, T; Makishima, K; Palmer, D M; Goldsten, J; Del Monte, E; Feroci, M; Marisaldi, M

    2011-01-01

    In the first two years of operation of the Fermi GBM, the 9-spacecraft Interplanetary Network (IPN) detected 158 GBM bursts with one or two distant spacecraft, and triangulated them to annuli or error boxes. Combining the IPN and GBM localizations leads to error boxes which are up to 4 orders of magnitude smaller than those of the GBM alone. These localizations comprise the IPN supplement to the GBM catalog, and they support a wide range of scientific investigations.

  13. GBM: a gamma-ray burst monitor for GLAST

    Science.gov (United States)

    Lichti, Giselher G.; Briggs, Michael S.; Diehl, Roland; Fishman, Gerald J.; Kippen, Richard M.; Kouveliotou, Chryssa; Meegan, Charles A.; Paciesas, William S.; Preece, Robert S.; Schoenfelder, Volker; von Kienlin, Andreas

    2003-03-01

    One of the scientific objectives of the GLAST mission is the study of gamma-ray bursts (GRBs) which will be measured by the Large-Area Telescope, the main instrument of GLAST, in the energy range from ~20 MeV to ~300 GeV. In order to extend the energy measurement towards lower energies a secondary instrument, the GLAST Burst Monitor (GBM) will measure GRBs from ~10 keV to ~25 MeV and will thus allow the investigation of the relation between the keV and the MeV-GeV emission from GRBs. The GBM consists of 12 circular NaI crystal discs and 2 cylindrical BGO crystals. The NaI crystals are optimized for gamma radiation from ~10 keV to ~1 MeV and the BGO crystals from ~150 keV to ~25 MeV. The NaI crystals are oriented in such a way that the measured relative counting rates allow a rapid determination of the position of a gamma-ray burst within a wide FoV of ~8.6 sr. This position will be communicated within seconds to the LAT which may then be reoriented to observe the long-lasting high-energy gamma-ray emission from GRBs. This will allow the exploration of the unknown aspects of the high-energy burst emission and their connection with the well-known low-energy emission. Another important feature of the GBM is its high time resolution of ~10 microseconds for time-resolved gamma-ray spectroscopy.

  14. Vietnam in Childrens' Books.

    Science.gov (United States)

    United Nations Children's Fund, New York, NY. United States Committee.

    Twenty-five nonfiction and 18 fiction and folklore listings are included in this bulletin on Vietnam in childrens' books. Slides, filmstrips, and film listings are also included. Each listing is accompanied by a brief annotation. Subjects include customs and culture, the country and the people, Ho Chi Min, the Vietnamese revolution, Vietnamese…

  15. Connect the Book. Benjamin Franklin

    Science.gov (United States)

    Brodie, Carolyn S.

    2004-01-01

    This article presents a brief review of James Cross Giblin's "The Amazing Life of Benjamin Franklin" (Scholastic, 2000). This book provides a real look at the life of one of America's most famous statesmen who was also a printer, inventor, and writer. The book additionally includes a chronology of Franklin's life, information about his many…

  16. AI-05IMPACT OF GBM MICROENVIRONMENT ON EXPRESSION PROFILE OF BONE MARROW DERIVED PROGENITOR CELLS

    OpenAIRE

    Burrell, Kelly; Singh, Sanjay; Agnihotri, Sameer; Hill, Richard; Aldape, Kenneth; Zadeh, Gelareh

    2014-01-01

    We have recently shown that bone marrow derived cells (BMDC) provide a distinct tumor region dependent contribution to glioblastoma multiforme (GBM) neovascularization. The influence of GBM microenvironment on differentiation and modulation of expression factors by BMDC however remains unknown. In this study we establish the differential expression profile of BMDC as a consequence of recruitment and interaction with the GBM microenvironment and in response to radiation (RTx) and anti-angiogen...

  17. A possible association of partial lipodystrophy with anti-GBM nephritis (Goodpasture's syndrome).

    OpenAIRE

    Blake, D. R.; Rashid, H.; McHugh, M.; Morley, A. R.

    1980-01-01

    Partial lipodystrophy is known to be associated with mesangiocapillary glomerulonephritis. A case is described of a possible association of partial lipodystrophy with anti-GBM nephritis (Goodpasture's syndrome).

  18. Book Review: Book review

    Science.gov (United States)

    Clevers, Jan G. P. W.

    2016-09-01

    For many years a good introductory book for undergraduate and postgraduate students on remote sensing of the Earth's land surface, which was not starting with an emphasis on traditional photographic techniques, was missing. In 2010 the first edition of the book Fundamentals of Satellite Remote Sensing by Emilio Chuvieco and Alfredo Huete was published by CRC Press and it was filling this gap. Now the second edition by Emilio Chuvieco was published by CRC Press. This second edition is made more attractive by the use of colour and including colour illustrations instead of the black-and-white ones in the first edition.

  19. Book Review: Book review

    Science.gov (United States)

    Mishchenko, Michael I.

    2017-07-01

    This fundamental (and in many respects encyclopedic) 755-page monograph was published as part of the ;Mario Boella Series on Electromagnetism in Information and Communication; edited by P. L. E. Uslenghi. The main purpose of the book is systematic exposition of several important aspects of the electromagnetic scattering theory along with the presentation of the requisite mathematical apparatus and illustrative numerical results. What distinguishes this volume from the vast majority of related books is the extensive treatment of the time-domain scattering theory.

  20. Book Review:

    Science.gov (United States)

    Folacci, Antoine; Jensen, Bruce

    2003-12-01

    Thanks to its impressive success in the second half of the 20th century, both in high-energy physics and in critical phenomena, quantum field theory has enjoyed an abundant literature. We therefore greet yet another book on this subject with caution: what can a monograph on quantum field theory bring now that is new, either conceptually or pedagogically? But when it is written by a physicist such as Bryce DeWitt, who has made his own contribution to the collection of field theory books with The Global Approach to Quantum Field Theory, all suspicion is naturally abandoned. One knows in advance that this book can only lead to a genuine enrichment of the literature. DeWitt has made a formidable contribution to various areas of physics: general relativity, the interpretation of quantum mechanics, and most of all the quantization of non-Abelian gauge theories and quantum gravity. In addition, his pedagogical publications, especially the Les Houches schools of 1963 and 1983 [1, 2], have had a great impact on quantum field theory. All this makes the reader keen to pick up his new work and a deeper reading confirms the reviewer's initial enthusiasm. We must begin by alerting the potential readers of this book that it cannot be compared to any other book in the field (unless of course we are talking about references [1] and [2], of which the book under review is an extension and reworking). This uniqueness applies to both the scientific content and the way the ideas are presented. A quick description of this book and a brief explanation of its title should convince the reader of the book's unique quality. For DeWitt, a central concept of field theory is that of `space of histories'. For a field varphii defined on a given spacetime M, the set of all varphii(x) for all x in all charts of M defines its history. It is the space Phi of all possible histories (dynamically allowed or not) of the fields defined on M which is called the `space of histories' by DeWitt. If only

  1. The Fermi-GBM Gamma-Ray Burst Catalogs: The First Six Years

    Directory of Open Access Journals (Sweden)

    Bissaldi E.

    2017-01-01

    Full Text Available Since its launch in 2008, the Fermi Gamma-ray Burst Monitor (GBM has triggered and located on average approximately two gamma-ray bursts (GRBs every three days. Here we present the main results from the latest two catalogs provided by the Fermi-GBM science team, namely the third GBM GRB catalog [1] and the first GBM time-resolved spectral catalog [2]. The intention of the GBM GRB catalog is to provide information to the community on the most important observables of the GBM detected bursts. It comprises 1405 triggers identified as GRBs. For each one, location and main characteristics of the prompt emission, the duration, the peak flux and the fluence are derived. The GBM time-resolved spectral catalog presents high-quality time-resolved spectral analysis with high temporal and spectral resolution of the brightest bursts observed by Fermi GBM in a shorter period than the former catalog, namely four years. It comprises 1491 spectra from 81 bursts. Distributions of parameters, statistics of the parameter populations, parameter-parameter and parameter-uncertainty correlations, and their exact values are obtained.

  2. Book Review:

    Science.gov (United States)

    Das, Ashok

    2007-01-01

    It is not usual for someone to write a book on someone else's Ph.D. thesis, but then Feynman was not a usual physicist. He was without doubt one of the most original physicists of the twentieth century, who has strongly influenced the developments in quantum field theory through his many ingenious contributions. Path integral approach to quantum theories is one such contribution which pervades almost all areas of physics. What is astonishing is that he developed this idea as a graduate student for his Ph.D. thesis which has been printed, for the first time, in the present book along with two other related articles. The early developments in quantum theory, by Heisenberg and Schrödinger, were based on the Hamiltonian formulation, where one starts with the Hamiltonian description of a classical system and then promotes the classical observables to noncommuting quantum operators. However, Dirac had already stressed in an article in 1932 (this article is also reproduced in the present book) that the Lagrangian is more fundamental than the Hamiltonian, at least from the point of view of relativistic invariance and he wondered how the Lagrangian may enter into the quantum description. He had developed this idea through his 'transformation matrix' theory and had even hinted on how the action of the classical theory may enter such a description. However, although the brief paper by Dirac contained the basic essential ideas, it did not fully develop the idea of a Lagrangian description in detail in the functional language. Feynman, on the other hand, was interested in the electromagnetic interactions of the electron from a completely different point of view rooted in a theory involving action-at-a-distance. His theory (along with John Wheeler) did not have a Hamiltonian description and, in order to quantize such a theory, he needed an alternative formulation of quantum mechanics. When the article by Dirac was brought to his attention, he immediately realized what he was

  3. Apparent diffusion coefficient in glioblastoma with PNET-like components, a GBM variant.

    Science.gov (United States)

    Ali, Saad; Joseph, Nancy M; Perry, Arie; Barajas, Ramon F; Cha, Soonmee

    2014-09-01

    Glioblastoma (GBM) with primitive neuroectodermal tumor (PNET)-like (GBM-PNET) components is a rare variant of GBM. Recent studies describe PNET-like clinical behavior in these patients-with significantly increased propensity for CSF dissemination and a benefit of "PNET-like" chemotherapy. The imaging appearance of GBM-PNET is not well-described and given areas of marked cellularity in the PNET components one might expect significantly reduced diffusion on MRI. The purpose of this study is to quantitatively evaluate the diffusion characteristics in GBM-PNET and compare them with conventional GBMs. Nine patients with surgical specimens yielding GBM-PNET were identified from the UCSF Pathology files. MR images of these patients were reviewed retrospectively. DWI (diffusion-weighted imaging) sequences were analyzed with multiple regions of interests placed within the tumor, and ADC (apparent diffusion coefficient) values were measured. Results were compared to previously published ADC values in pathology-proven conventional GBM cases from our institution. Reduced ADC was seen in GBM-PNET (mean 581 × 10(-6) mm(2)/s, range 338-817) compared to previously published mean of 1,030 × 10(-6) mm(2)/s in the enhancing components of conventional GBMs. We report substantially reduced ADC values in GBM-PNETs compared to conventional GBMs. If demonstrated in a larger sample, when areas of marked reduced diffusion are seen in a suspected GBM, MRI may appropriately direct tissue sampling and can advocate a thorough search for PNET-like components on histopathology. These patients may have a higher chance of developing CSF dissemination and may benefit from "PNET-like" platinum-based chemotherapy.

  4. Book Review: Book review

    Science.gov (United States)

    van der Linden, Sebastian

    2016-05-01

    Compiling a good book on urban remote sensing is probably as hard as the research in this disciplinary field itself. Urban areas comprise various environments and show high heterogeneity in many respects, they are highly dynamic in time and space and at the same time of greatest influence on connected and even tele-connected regions due to their great economic importance. Urban remote sensing is therefore of great importance, yet as manifold as its study area: mapping urban areas (or sub-categories thereof) plays an important (and challenging) role in land use and land cover (change) monitoring; the analysis of urban green and forests is by itself a specialization of ecological remote sensing; urban climatology asks for spatially and temporally highly resolved remote sensing products; the detection of artificial objects is not only a common and important remote sensing application but also a typical benchmark for image analysis techniques, etc. Urban analyses are performed with all available spaceborne sensor types and at the same time they are one of the most relevant fields for airborne remote sensing. Several books on urban remote sensing have been published during the past 10 years, each taking a different perspective. The book Global Urban Monitoring and Assessment through Earth Observation is motivated by the objectives of the Global Urban Observation and Information Task (SB-04) in the GEOSS (Global Earth Observation System of Systems) 2012-2015 workplan (compare Chapter 2) and wants to highlight the global aspects of state-of-the-art urban remote sensing.

  5. Book Review: Book review

    Science.gov (United States)

    Wang, Christina Yan

    2017-02-01

    The world class Ni-Cu-PGE sulfide deposits associated with the Sudbury Igneous Complex (SIC) are quite unique on earth in the sense that the energy source and origin were triggered by a large meteorite impact event. The ore deposits in the SIC make up one of the largest Ni-Cu-PGE sulfide deposit camps in the world and have now been mined for over 100 years. This is the first complete reference book that focuses entirely on the SIC and covers the fields of economic geology, petrology, geochemistry and geophysics. The purpose of this book is to explore the linkage between sulfide and silicate magmas generated by the 1.85 Ga Sudbury impact event and to unite an understanding of the process of crustal melt sheet evolution with the formation of the magmatic sulfide mineralization. The author, Peter Lightfoot, has been based in Sudbury for 25 years. As a top scientist on magmatic Ni-Cu-PGE sulfide deposits and a Chief Geologist with the Brownfield Exploration group at Vale Base Metals, Peter has been positioned to develop and assemble the ideas presented in this book, which are perfectly balanced between industry and academia.

  6. 中國大陸非國有書業發展歷程研究 A Brief History of Non-state-owned Book Industry on the Mainland of P. R. China

    Directory of Open Access Journals (Sweden)

    Qing Fang

    2005-06-01

    Full Text Available 文章對中華人民共和國成立以來,中國大陸非國有書業發展歷程進行了系統回顧與分析。作者將1949年以來大陸書業的發展以1980年為界劃分為前後兩個階 段,前一階段為非國有書業的限制發展時期;後一階段為鼓勵發展時期。文章重點分析了1980年以來大陸非國有書業發展的三個步驟,即1980年非國有經濟 開始進入圖書零售領域;1988年非國有經濟得以進入圖書二級批發環節;2003年圖書的總發行權和全國連鎖經營權的大門開始向非國有經濟敞開。This article reviews and analyzes the brief history of the Non-state-owned Book Industry on the Mainland of P. R. China since 1949, which is divided into two stages by the year of 1980. The first phase is a restriction period and the second one is an encouragement period. The article focuses especially on the 3 steps of the second stage, namely: firstly, Non-state-owned enterprises was permitted to enter the book retailing sector in 1980; secondly, Second level wholesale right could he delegated to privately-owned enterprises in 1988; thirdly, general distribution right and the chain bookstores operation right were opened tip to the Non-state-owned enterprises.

  7. Book Review: Book review

    Science.gov (United States)

    Pulte, Helmut

    In his Erkenntnisproblem, Ernst Cassirer described Heinrich Hertz (1857-1894) as the first great physicist who consequently elaborated a both hypothetical and objective concept of scientific theory, i.e. an understanding of physical theory, which combines a logical rigorous analysis of the different possibilities of conceptual foundation with a carefully thought-out renunciation of absolute truth for one of these possibilities. This judgment mainly refers to Hertz's book Die Prinzipien der Mechanik, in neuem Zusammenhange dargestellt (1894), which was the main result of his scientific research during the last 3 years of his short life.

  8. Book Review: Book review

    Science.gov (United States)

    da Costa, Newton C. A.; Krause, Décio

    This book contains a representative selection of Erhard Scheibe's writings on the philosophy of physics. It encompasses eight sections, with 38 papers, distributed as follows: (I) Between Rationalism and Empiricism (five papers from 1969 to 1994); (II) The Philosophy of the Physicists (five papers from 1988 to 1995); (III) Reconstruction (four papers, from 1979 to 1988); (IV) Laws of Nature (five papers, from 1989 to 1998); (V) Reduction (five papers from 1973 to 1995); (VI) Foundations of Quantum Mechanics (six papers from 1985 to 1993); (VII) Spacetime, Invariance, Covariance (four papers from 1982 to 1994), and (VIII) Mathematics and Physics (four papers from 1977 to 1997).

  9. Book Review: Book review

    Science.gov (United States)

    Mishchenko, Michael I.

    2017-01-01

    The second - revised and enlarged - edition of this popular monograph is co-authored by Michael Kahnert and is published as Volume 145 of the Springer Series in Optical Sciences. As in the first edition, the main emphasis is on the mathematics of electromagnetic scattering and on numerically exact computer solutions of the frequency-domain macroscopic Maxwell equations for particles with complex shapes. The book is largely centered on Green-function solution of relevant boundary value problems and the T-matrix methodology, although other techniques (the method of lines, integral equation methods, and Lippmann-Schwinger equations) are also covered. The first four chapters serve as a thorough overview of key theoretical aspects of electromagnetic scattering intelligible to readers with undergraduate training in mathematics. A separate chapter provides an instructive analysis of the Rayleigh hypothesis which is still viewed by many as a highly controversial aspect of electromagnetic scattering by nonspherical objects. Another dedicated chapter introduces basic quantities serving as optical observables in practical applications. A welcome extension of the first edition is the new chapter on group theoretical aspects of electromagnetic scattering by particles with discrete symmetries. An essential part of the book is the penultimate chapter describing in detail popular public-domain computer programs mieschka and Tsym which can be applied to a wide range of particle shapes. The final chapter provides a general overview of available literature on electromagnetic scattering by particles and gives useful reading advice.

  10. Recent Noteworthy Young Adult Books about Latinos/as.

    Science.gov (United States)

    Schon, Isabel

    1999-01-01

    Offers brief descriptions of 16 books in English (published in 1997 and 1998) about Latino people and cultures. Arranges these noteworthy books into five broad areas: fiction, history, literature, poetry, and sociology. (SR)

  11. THE FERMI GBM GAMMA-RAY BURST CATALOG: THE FIRST TWO YEARS

    Energy Technology Data Exchange (ETDEWEB)

    Paciesas, William S.; Bhat, P. N.; Briggs, Michael S.; Burgess, J. Michael; Chaplin, Vandiver; Connaughton, Valerie; Goldstein, Adam; Guiriec, Sylvain [Center for Space Plasma and Aeronomic Research, University of Alabama in Huntsville, 320 Sparkman Drive, Huntsville, AL 35805 (United States); Meegan, Charles A.; Van der Horst, Alexander J. [Universities Space Research Association, 320 Sparkman Drive, Huntsville, AL 35805 (United States); Von Kienlin, Andreas; Diehl, Roland; Foley, Suzanne; Greiner, Jochen; Gruber, David [Max-Planck-Institut fuer extraterrestrische Physik, Giessenbachstrasse 1, 85748 Garching (Germany); Bissaldi, Elisabetta [Institute of Astro and Particle Physics, University Innsbruck, Technikerstrasse 25, 6176 Innsbruck (Austria); Fishman, Gerald J. [Space Science Office, VP62, NASA/Marshall Space Flight Center, Huntsville, AL 35812 (United States); Fitzpatrick, Gerard [School of Physics, University College Dublin, Belfield, Stillorgan Road, Dublin 4 (Ireland); Gibby, Melissa; Giles, Misty [Jacobs Technology, Inc., 1525 Perimeter Pkwy NW, Huntsville, AL 35806 (United States); and others

    2012-03-01

    The Fermi Gamma-ray Burst Monitor (GBM) is designed to enhance the scientific return from Fermi in studying gamma-ray bursts (GRBs). In its first two years of operation GBM triggered on 491 GRBs. We summarize the criteria used for triggering and quantify the general characteristics of the triggered GRBs, including their locations, durations, peak flux, and fluence. This catalog is an official product of the Fermi GBM science team, and the data files containing the complete results are available from the High-Energy Astrophysics Science Archive Research Center.

  12. Selecting "App"ealing and "App"ropriate Book Apps for Beginning Readers

    Science.gov (United States)

    Cahill, Maria; McGill-Franzen, Anne

    2013-01-01

    Beginning with a brief rationale for selecting quality digital picture book apps for beginning readers, the authors describe the elements of digital picture books and provide a brief review of the instructional benefits of digital picture book use for beginning readers. They then present a detailed taxonomy for selecting quality picture book apps.…

  13. Selecting "App"ealing and "App"ropriate Book Apps for Beginning Readers

    Science.gov (United States)

    Cahill, Maria; McGill-Franzen, Anne

    2013-01-01

    Beginning with a brief rationale for selecting quality digital picture book apps for beginning readers, the authors describe the elements of digital picture books and provide a brief review of the instructional benefits of digital picture book use for beginning readers. They then present a detailed taxonomy for selecting quality picture book apps.…

  14. Computer Implementation of a New Therapeutic Model for GBM Tumor

    Directory of Open Access Journals (Sweden)

    Ali Jamali Nazari

    2014-01-01

    Full Text Available Modeling the tumor behavior in the host organ as function of time and radiation dose has been a major study in the previous decades. Here the effort in estimation of cancerous and normal cell proliferation and growth in glioblastoma multiform (GBM tumor is presented. This paper introduces a new mathematical model in the form of differential equation of tumor growth. The model contains dose delivery amount in the treatment scheme as an input term. It also can be utilized to optimize the treatment process in order to increase the patient survival period. Gene expression programming (GEP as a new concept is used for estimating this model. The LQ model has also been applied to GEP as an initial value, causing acceleration and improvement of the algorithm estimation. The model shows the number of the tumor and normal brain cells during the treatment process using the status of normal and cancerous cells in the initiation of treatment, the timing and amount of dose delivery to the patient, and a coefficient that describes the brain condition. A critical level is defined for normal cell when the patient’s death occurs. In the end the model has been verified by clinical data obtained from previous accepted formulae and some of our experimental resources. The proposed model helps to predict tumor growth during treatment process in which further treatment processes can be controlled.

  15. Fermi/GBM Observations of SGR J0501+4516

    Science.gov (United States)

    Lin, Lin; Kouveliotou, Chryssa; van der Horst, Alexander J.

    2011-08-01

    The magnetar candidate SGR J0501+4516 was discovered when it became active for about 13 days from August 22 to September 3, 2008. During this period, the Gamma-ray Burst Monitor (GBM) onboard Fermi detected over 30 bursts. We present here our results on the temporal and spectral analysis of the 29 bursts for which high spectral and time resolution data is available. We find that the T90 durations of the bursts follow a log-normal distribution with a mean value of ~123 ms. We fit the time-integrated spectrum of each burst with several models: a black body function, optically thin thermal brehmsstrahlung, a power law with an exponential cut-off, two black body functions, and the combination of a black body and a power law. We discuss our results in the context of the spectral properties of other magnetar bursts and we also present some correlations between the spectral parameters of the best fit models for all bursts. Finally, we present the results of our time-resolved spectral analysis of the five brightest bursts and discuss how they compare with our time-integrated results.

  16. Book Review:

    Science.gov (United States)

    Kiefer, C.

    2005-10-01

    with respect to this external time. But in quantum gravity there is no background structure, in particular no external time. Secondly, there exist two important operators that are connected, respectively, with area and volume in the classical limit. These operators have a discrete spectrum and thus provide elementary 'quanta' of area and volume. This gives a vague hint of a discrete structure at the Planck scale, about which there were speculations for many decades. In spite of these promising results, loop quantum gravity is still far away from a physical theory. This is also reflected in this volume where the technical treatment prevails and where physical applications are relegated to about 20 pages. These applications deal with quantum cosmology and black holes. The part on loop quantum cosmology summarizes briefly recent results about a possible singularity avoidance and a new mechanism for inflation. These results are not derived from loop quantum gravity but from imposing the discrete structure of the full theory directly on the quantum cosmological models. The part on black holes discusses the derivation of the Bekenstein-Hawking entropy from counting the number of relevant spin-network states. Since the theory contains a free parameter (the 'Barbero-Immirzi parameter'), the best one can do is to determine this parameter by demanding that the result be the Bekenstein-Hawking entropy. The book does not yet contain the results of recent papers, published in 2004, that correct the earlier entropy calculations presented here. From the new value of the Barbero-Immirzi parameter, the appealing connection with quasi-normal modes, as discussed in the book, may be lost. The book concludes with a brief discussion of the major open issues. Among these are the following: a well-defined and physically sensible semiclassical limit, the precise form of the Hamiltonian, the role of unification (most of the work in loop quantum gravity deals only with pure gravity) and, last

  17. Book Review:

    Science.gov (United States)

    Barbour, J. B.

    2007-02-01

    These colloquium proceedings will be valuable, the blurb says, for graduate students and researchers in cosmology and theoretical astrophysics. Specifically, the book 'looks at both the strengths and weaknesses of the current big bang model in explaining certain puzzling data' and gives a 'comprehensive coverage of the expanding field of cosmology'. The reality is rather different. Conference proceedings rarely compare in value with a solid monograph or good review articles, and Current Issues in Cosmology is no exception. The colloquium was convened by the two editors, who have both long harboured doubts about the big bang, and was held in Paris in June 2004. The proceedings contain 19 presented papers and relatively brief summary comments by four panel speakers. The questions and answers at the end of each talk and a general discussion at the end were recorded and transcribed but contain little of interest. The nature of the colloquium is indicated by panellist Francesco Bertola's comment: 'While in the 1950s it was possible to speak of rival theories in cosmology, now the big-bang picture has no strong rivals. This is confirmed by the fact that out of 1500 members of the IAU Division VIII (Galaxies and the Universe) only a dozen, although bright people, devote their time to the heterodox views.' This was largely a platform for them to give their views. At least half of the dozen, all the 'usual suspects', were present: Geoffery and Margaret Burbidge, Jayant Narlikar, Halton Arp, Chandra Wickramasinghe and, in spirit only but playing a role somewhat like the ghost of Hamlet's father, the late Fred Hoyle. Doubters presented 12 of the 19 papers. Orthodoxy should certainly be challenged and the sociology of science questioned, but I found two main problems with this book. The papers putting the orthodox view are too short, even perfunctory. The most that a serious graduate student would get out of them is a reference to a far better review article or book on modern

  18. Book Review:

    Science.gov (United States)

    Poisson, E.

    2005-10-01

    of cosmological perturbations; this is a surprising omission, since the presentation of the linearized theory in chapter 7 is so clearly inspired by the cosmological problem. I am equally disappointed not to find a detailed discussion of the CMBR anisotropies; this omission also is surprising, since the peak structure of their multipole moments makes such a compelling case for inflationary ideas. Given that Carroll is a working cosmologist, it is indeed a surprise to me that this chapter on cosmology happens to be so brief. The ninth and final chapter of Carroll's book is devoted to a topic that has never been covered in an introductory text: quantum field theory in curved spacetime. To include this was a truly inspired thought, and Carroll is to be congratulated for this initiative. Quantum-field processes play an essential role in the physics of structure formation in the early universe, and they give rise to the famous Hawking effect which causes a black hole to behave as a thermal body. A complete education in general relativity cannot exclude this important subject, and we now have a textbook which presents it in a clear, accessible way. In summary, I am positively impressed by this book, in spite of the fact that I find it to be flawed in certain places. I firmly believe that the book stands proud among the best relativity texts. Would I use it in a general relativity course? The answer is: surely, given the right group of students. In the past I have had the pleasure of teaching both an introductory course for undergraduates and an advanced course for graduate students. In my opinion, none of these student groups are a good match for Carroll's book. For the undergraduate course I would choose Hartle over Carroll, as I much favour the physics-first approach. For the graduate course I rely on an existing working knowledge of general relativity and I cover advanced topics that are not found in Carroll's text. The right target group, I imagine, would be graduate

  19. Demethoxycurcumin Retards Cell Growth and Induces Apoptosis in Human Brain Malignant Glioma GBM 8401 Cells

    Directory of Open Access Journals (Sweden)

    Tzuu-Yuan Huang

    2012-01-01

    Full Text Available Demethoxycurcumin (DMC; a curcumin-related demethoxy compound has been recently shown to display antioxidant and antitumor activities. It has also produced a potent chemopreventive action against cancer. In the present study, the antiproliferation (using the MTT assay, DMC was found to have cytotoxic activities against GBM 8401 cell with IC50 values at 22.71 μM and induced apoptosis effects of DMC have been investigated in human brain malignant glioma GBM 8401 cells. We have studied the mitochondrial membrane potential (MMP, DNA fragmentation, caspase activation, and NF-κB transcriptional factor activity. By these approaches, our results indicated that DMC has produced an inhibition of cell proliferation as well as the activation of apoptosis in GBM 8401 cells. Both effects were observed to increase in proportion with the dosage of DMC treatment, and the apoptosis was induced by DMC in human brain malignant glioma GBM 8401 cells via mitochondria- and caspase-dependent pathways.

  20. Crescentic Glomerulonephritis with Anti-GBM and p-ANCA Antibodies

    Directory of Open Access Journals (Sweden)

    Tariq Javed

    2012-01-01

    Full Text Available We are presenting a case of renal failure with anti-GBM and p-ANCA antibodies positive. Patients with dual antibodies are considered to be a vasculitis-variant of anti-GBM antibody nephritis. These patients may have atypical presentation and it may delay diagnosis and treatment. Recurrence rate is higher in these patients. We reviewed the literature of cases and studies on cresenteric glomerulonephritis with anti-GBM and p-ANCA positive patients. We recommend that patients suspected with pulmonary-renal syndrome should be checked for anti-GBM and p-ANCA antibodies, should undergo renal biopsy and should should have close long term follow up to watch for recurrence.

  1. Dismantling of the EB experiment: Experimental research on the retrieved GBM and bentonite blocks

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Jiang-Feng, E-mail: jeafliu@hotmail.com [State Key Laboratory for Geomchanics & Deep Underground Engineering, and School of Mechanics and Civil Engineering, China University of Mining & Technology, Xuzhou, Jiangsu 221116 (China); Laboratoire de Méchanique de Lille (LML), and École Centrale de Lille, BP 48, F-59651 Villeneuve d’Ascq Cedex (France); Skoczylas, Frédéric [Laboratoire de Méchanique de Lille (LML), and École Centrale de Lille, BP 48, F-59651 Villeneuve d’Ascq Cedex (France); Talandier, Jean [ANDRA, 1-7 rue Jean Monnet, 92298 Châtenay-Malabry Cedex (France); Pu, Hai [State Key Laboratory for Geomchanics & Deep Underground Engineering, and School of Mechanics and Civil Engineering, China University of Mining & Technology, Xuzhou, Jiangsu 221116 (China)

    2016-04-15

    Graphical abstract: - Highlights: • We present a demonstration of a new concept of HLW (high-level waste) repositories. • The hydro-mechanical characteristics of GBM and blocks were determined. • The water retention curves (WRCs) of GBM and blocks were presented. • The effective gas permeability of the GBM and blocks were measured. • The homogeneity of the GBM and blocks were investigated. - Abstract: The Engineered Barrier Emplacement Experiment in Opalinus Clay (EB experiment) was a full-scale test for the demonstration of a new concept of high-level waste (HLW) repositories in horizontal drifts in the Opalinus Clay formation. After 10.5 years of hydration, the EB experiment was dismantled in autumn 2012. Samples obtained from the granular bentonite material (GBM), and bentonite blocks were sent to a laboratory for further analysis. The bentonite samples analyzed at the Laboratory of Mechanic of Lille (LML) were obtained from the CMT1, CMT2, CMT3 and RW sections. Their physical states were determined, as were their effective gas permeability and swelling capacity at different relative humidity (RH) levels. The results indicate that the water contents of the GBM determined in the laboratory ranged between 25.63% and 44.88% and that the dry densities ranged between 1.13 and 1.44 g/cm{sup 3}. The blocks had water contents similar to (or slightly higher than) those of the GBM, and their dry densities had decreased from an initial value of 1.69 g/cm{sup 3} to values close to 1.30 g/cm{sup 3}, which were similar to the average values found in the GBM. The effective gas permeabilities of the GBM samples were within the range of 1.50 × 10{sup −22} m{sup 2} and 1.03 × 10{sup −17} m{sup 2}, whereas, the corresponding values of the samples obtained from the blocks were between 2.20 × 10{sup −21} m{sup 2} and 5.12 × 10{sup −21} m{sup 2}. The permeability values are primarily related to the dry densities and water contents of the samples. Contact with

  2. THE INTERPLANETARY NETWORK SUPPLEMENT TO THE FERMI GBM CATALOG OF COSMIC GAMMA-RAY BURSTS

    Energy Technology Data Exchange (ETDEWEB)

    Hurley, K. [University of California, Berkeley, Space Sciences Laboratory, 7 Gauss Way, Berkeley, CA 94720-7450 (United States); Pal' shin, V. D.; Aptekar, R. L.; Golenetskii, S. V.; Frederiks, D. D.; Mazets, E. P.; Svinkin, D. S. [Ioffe Physical Technical Institute, St. Petersburg 194021 (Russian Federation); Briggs, M. S.; Connaughton, V. [University of Alabama in Huntsville, NSSTC, 320 Sparkman Drive, Huntsville, AL 35805 (United States); Meegan, C. [Universities Space Research Association, NSSTC, 320 Sparkman Drive, Huntsville, AL 35805 (United States); Goldsten, J. [Applied Physics Laboratory, Johns Hopkins University, Laurel, MD 20723 (United States); Boynton, W.; Fellows, C.; Harshman, K. [University of Arizona, Department of Planetary Sciences, Tucson, AZ 85721 (United States); Mitrofanov, I. G.; Golovin, D. V.; Kozyrev, A. S.; Litvak, M. L.; Sanin, A. B. [Space Research Institute, 84/32, Profsoyuznaya, Moscow 117997 (Russian Federation); Rau, A., E-mail: khurley@ssl.berkeley.edu [Max-Planck-Institut fuer extraterrestrische Physik, Giessenbachstrasse, Postfach 1312, D-85748 Garching (Germany); and others

    2013-08-15

    We present Interplanetary Network (IPN) data for the gamma-ray bursts in the first Fermi Gamma-Ray Burst Monitor (GBM) catalog. Of the 491 bursts in that catalog, covering 2008 July 12 to 2010 July 11, 427 were observed by at least one other instrument in the nine-spacecraft IPN. Of the 427, the localizations of 149 could be improved by arrival time analysis (or {sup t}riangulation{sup )}. For any given burst observed by the GBM and one other distant spacecraft, triangulation gives an annulus of possible arrival directions whose half-width varies between about 0.'4 and 32 Degree-Sign , depending on the intensity, time history, and arrival direction of the burst, as well as the distance between the spacecraft. We find that the IPN localizations intersect the 1{sigma} GBM error circles in only 52% of the cases, if no systematic uncertainty is assumed for the latter. If a 6 Degree-Sign systematic uncertainty is assumed and added in quadrature, the two localization samples agree about 87% of the time, as would be expected. If we then multiply the resulting error radii by a factor of three, the two samples agree in slightly over 98% of the cases, providing a good estimate of the GBM 3{sigma} error radius. The IPN 3{sigma} error boxes have areas between about 1 arcmin{sup 2} and 110 deg{sup 2}, and are, on the average, a factor of 180 smaller than the corresponding GBM localizations. We identify two bursts in the IPN/GBM sample that did not appear in the GBM catalog. In one case, the GBM triggered on a terrestrial gamma flash, and in the other, its origin was given as ''uncertain''. We also discuss the sensitivity and calibration of the IPN.

  3. On the GBM event seen 0.4 sec after GW 150914

    CERN Document Server

    Greiner, J; Savchenko, V; Yu, H -F

    2016-01-01

    In view of the recent report by Connaughton [arXiv:1602.03920.v3] we analyse continuous TTE data of Fermi-GBM around the time of the gravitational wave event GW 150914. We find that after proper accounting for low count statistics, the GBM transient event at 0.4 s after GW 150914 is likely not due to an astrophysical source, but consistent with a background fluctuation, removing the tension between the INTEGRAL/ACS non-detection and GBM. Additionally, reanalysis of other short GRBs shows that without proper statistical modeling the fluence of faint events is over-predicted, as verified for some joint GBM-ACS detections of short GRBs. We detail the statistical procedure to correct these biases. As a result, faint short GRBs, verified by ACS detections, with significances in the broad-band light curve even smaller than that of the GBM-GW150914 event are recovered as proper non-zero source, while the GBM-GW150914 event is consistent with zero fluence.

  4. Investigating a signature of temozolomide resistance in GBM cell lines using metabolomics.

    Science.gov (United States)

    St-Coeur, Patrick-Denis; Poitras, Julie J; Cuperlovic-Culf, Miroslava; Touaibia, Mohamed; Morin, Pier

    2015-10-01

    Glioblastoma multiforme (GBM) is the most common form of malignant glioma. Current therapeutic approach to treat this malignancy involves a combination of surgery, radiotherapy and chemotherapy with temozolomide. Numerous mechanisms contributing to inherent and acquired resistance to this chemotherapeutic agent have been identified and can lead to treatment failure. This study undertook a metabolomics-based approach to characterize the metabolic profiles observed in temozolomide-sensitive and temozolomide-resistant GBM cell lines as well as in a small sub-set of primary GBM tumors. This approach was also utilized to explore the metabolic changes modulated upon cell treatment with temozolomide and lomeguatrib, an MGMT inhibitor with temozolomide-sensitizing potential. Metabolites previously explored for their potential role in chemoresistance including glucose, citrate and isocitrate demonstrated elevated levels in temozolomide-resistant GBM cells. In addition, a signature of metabolites comprising alanine, choline, creatine and phosphorylcholine was identified as up-regulated in sensitive GBM cell line across different treatments. These results present the metabolic profiles associated with temozolomide response in selected GBM models and propose interesting leads that could be leveraged for the development of therapeutic or diagnostic tools to impact temozolomide response in GBMs.

  5. Time Domain Astronomy with Fermi GBM in the Multi-messenger Era

    Science.gov (United States)

    Wilson-Hodge, Colleen A.

    2017-08-01

    As the Multi-Messenger era begins with detections of gravitational waves with LIGO and neutrinos with IceCube, the Fermi Gamma-ray Burst Monitor provides context observations of gamma-ray transients between 8 keV and 40 MeV. Fermi GBM has a wide field of view, high uptime, and both in-orbit triggering and high time resolution continuous data enabling offline searches for weaker transients. GBM detects numerous gamma-ray bursts (GRBs), soft gamma-ray repeaters, X-ray bursters, solar flares and terrestrial gamma-ray flashes. Longer timescale transients, predominantly in our galaxy so far, are detected using the Earth occultation technique and epoch-folding for periodic sources. The GBM team has developed two ground-based searches to enhance detections of faint transients, especially short GRBs. The targeted search uses the time and location of an event detected with another instrument to coherently search the GBM data, increasing the sensitivity to a transient. The untargeted search agnostically searches the GBM data for all directions and times to find weaker transients. This search finds about 80 short GRBs per year, in addition to the 40 per year triggered on-orbit. With its large field of view, high duty cycle and increasingly sophisticated detection methods, Fermi GBM is expected to have a major role in the Multi-Messenger era.

  6. On the Fermi-GBM Event 0.4 s after GW150914

    Science.gov (United States)

    Greiner, J.; Burgess, J. M.; Savchenko, V.; Yu, H.-F.

    2016-08-01

    In view of the recent report by Connaughton et al., we analyze continuous time-tagged event (TTE) data of Fermi-gamma-ray burst monitor (GBM) around the time of the gravitational-wave event GW 150914. We find that after proper accounting for low-count statistics, the GBM transient event at 0.4 s after GW 150914 is likely not due to an astrophysical source, but consistent with a background fluctuation, removing the tension between the INTEGRAL/ACS non-detection and GBM. Additionally, reanalysis of other short GRBs shows that without proper statistical modeling the fluence of faint events is over-predicted, as verified for some joint GBM-ACS detections of short GRBs. We detail the statistical procedure to correct these biases. As a result, faint short GRBs, verified by ACS detections, with significances in the broadband light curve even smaller than that of the GBM-GW150914 event are recovered as proper non-zero source, while the GBM-GW150914 event is consistent with zero fluence.

  7. Is the GW150914-GBM really associated with the GW150914?

    CERN Document Server

    Xiong, Shaolin

    2016-01-01

    Finding the electromagnetic (EM) counterpart is critically important for a gravitational wave event. Although many efforts have been made to search for the purported EM counterpart of GW150914, the first gravitational wave event detected by LIGO, only Fermi/GBM reported an excess above background (i.e. GW150914-GBM) at 0.4 s after the LIGO trigger time, that is possibly associated with this GW event (Connaughton et al. 2016). However, since there is no significant detection by the INTEGRAL/SPI-ACS around the time of GW150914-GBM, a great debate has been raised about whether GW150914-GBM is of astrophysical origin and associated with the GW150914 (Savchenko et al. 2016). In order to answer this question, we re-analyzed the GBM data with a straightforward but sophisticated method. We find that the excess of GW150914-GBM mostly comes from those detectors with bad viewing angles to the GW event, whereas the good viewing detectors see nothing significant beyond background fluctuation around the trigger time of GW1...

  8. CERN Book Fair 2010 - Events and book presentations

    CERN Multimedia

    CERN Library

    2010-01-01

    A series of events and book presentations is scheduled for the 2010 CERN Book Fair.   -Springer will present its new products and services (eBooks, MyCopy Softcover Editions, SpringerBriefs, and a new physics journal: "Historical Perspectives on Contemporary Physics") and SpringerMaterials, the electronic version of the Landolt Boernstein book series. -Wiley will present two books: "A History of International Research Networking : The People who Made it Happen", edited by B. Bressan and H. Davies, and "Field computation for accelerator magnets : analytical and numerical methods for electromagnetic design and optimization" by S. Russenschuck. -Finally, World Scientific will present the series "Reviews of Accelerator Science and Technology (RAST)". The calendar is available here: http://indico.cern.ch/conferenceDisplay.py?confId=105651      

  9. My brief history

    CERN Document Server

    Hawking, Stephen

    2013-01-01

    My Brief History recounts Stephen Hawking’s improbable journey, from his postwar London boyhood to his years of international acclaim and celebrity. Lavishly illustrated with rarely seen photographs, this concise, witty, and candid account introduces readers to a Hawking rarely glimpsed in previous books: the inquisitive schoolboy whose classmates nicknamed him Einstein; the jokester who once placed a bet with a colleague over the existence of a particular black hole; and the young husband and father struggling to gain a foothold in the world of physics and cosmology. Writing with characteristic humility and humor, Hawking opens up about the challenges that confronted him following his diagnosis of ALS at age twenty-one. Tracing his development as a thinker, he explains how the prospect of an early death urged him onward through numerous intellectual breakthroughs, and talks about the genesis of his masterpiece A Brief History of Time—one of the iconic books of the twentieth century.

  10. Book Review:

    Science.gov (United States)

    Peacock, John

    2007-04-01

    The award of the 2006 Nobel Prize for Physics is a reminder to non-specialists that the cosmic microwave background (CMB) has yielded astonishing advances in our understanding of cosmology. Mather and Smoot received their prize for work done with NASA's COBE satellite in the early 1990s, but the subject has if anything accelerated since then. The results from NASA's WMAP satellite, reported in 2003 and 2006, have proved COBE's equal in importance and have generated huge worldwide interest. There could therefore hardly be a better time to be writing a detailed textbook to explain what the fuss is all about to a new generation of research students. A comprehensive treatment of the physics of the CMB is not easy to achieve, because it is connected to so much else in cosmology. A student must have a background knowledge of the geometry and dynamics of an expanding universe, plus a deep exposure to the physics of quantum fields, in order to understand the modern `inflationary' view in which the universe was set expanding by the tension of the vacuum, and was seeded with small inhomogeneities as a result of quantum fluctuations. Although the theory of inflation is not yet verified, the CMB has the potential to accomplish this; testing inflation is undoubtedly one of the principal aims of cosmology over the next decade. Even with this preparation, understanding the properties of the CMB is quite hard at the professional level, requiring the perturbation expansion of the relativistic Boltzmann equation. These technical difficulties are particularly strong in the frontier area of CMB polarization. Naselsky and his collaborators have allocated themselves a relatively brief 255 pages in which to meet these challenges, so some compromise is inevitable. Although the preface is not explicit about the assumed prior knowledge, no systematic material on background cosmology or on inflation is to be found. The former is reasonable in a graduate-level text (which this certainly is

  11. Design issues in the production of hyper-books and visual-books

    Directory of Open Access Journals (Sweden)

    Nadia Catenazzi

    1993-12-01

    Full Text Available This paper describes an ongoing research project in the area of electronic books. After a brief overview of the state of the art in this field, two new forms of electronic book are presented: hyper-books and visual-books. A flexible environment allows them to be produced in a semi-automatic way starting from different sources: electronic texts (as input for hyper-books and paper books (as input for visual-books. The translation process is driven by the philosophy of preserving the book metaphor in order to guarantee that electronic information is presented in a familiar way. Another important feature of our research is that hyper-books and visual-books are conceived not as isolated objects but as entities within an electronic library, which inherits most of the features of a paper-based library but introduces a number of new properties resulting from its non-physical nature.

  12. Solar consumer assurance network briefing book

    Energy Technology Data Exchange (ETDEWEB)

    Connor, Lynda

    1980-06-01

    Background information is provided on the rationale and purpose of the Solar Consumer Assurance Network (SOLCAN) program. Mechanisms being instituted by states to meet solar consumer assurance needs are identified. Mechanisms being developed with Federal government support to encourage solar consumer assurance activities are described. The operation of the FY 80 SOLCAN effort is described. (MHR)

  13. Paradox of Migration in Kolkata: A Megacity in GBM Delta

    Science.gov (United States)

    Das, S.; Hazra, S.; Ghosh, T.

    2015-12-01

    Contrary to other coastal cities (Mumbai, Chennai, Bhubaneswar etc.) in India, Kolkata, the largest city of India until 1990, has been showing a persistent trend of out-migration over the last decade. The situation is more paradoxical when compared to Dhaka in Bangladesh, the other coastal city in Ganga-Brahmaputra-Meghna (GBM) delta. Exacerbating impacts of Climate Change like accelerated sea level rise, impact of cyclones, rising temperature and high rainfall events and waterlogging, vis-à-vis the density of poor population in slums, Kolkata has been assessed as one of the most vulnerable cities of the world. However, Kolkata has long been a preferred destination for migrants for its port based economy, existence of industrial belt with labour intensive industries. The city and its surrounding districts attracted a massive influx of trans-border migrants when India and Bangladesh gained Independence in 1947 and 1971 respectively. The paper attempts to explore reasons behind the present trend of depopulation in the erstwhile preferred migration destination. This paper distinguishes between 'Kolkata City' (census district) with 4.5 million residents and 'Kolkata Megacity' which encompasses also the peri-urban areas and home to almost 14.1 million people according to Census 2011. Analysing migration as an ongoing research activity under DECCMA project, an overall 'in-migration' pattern can be deciphered in Kolkata 'megacity'. On the contrary, the Kolkata 'city' located right in the heart of the megacity exhibits negative net migration (-5.11%) i.e. high 'out-migration'. Plausible causes can be movement of people from Kolkata 'city' to peri-urban areas and satellite towns (urban to urban migration) probably due to closure of labour intensive industries, comparatively lower land prices, availability of space and accommodation, lower costs of living, development of different modes of commutation and communication. Further growth of population in the Kolkata Megacity

  14. Censoring the Imagination: Challenges to Children's Books.

    Science.gov (United States)

    Saltman, Judith

    1998-01-01

    Presents a brief history of the censorship of children's books, and then focuses on recent challenges. The view of literature as a socializing force is discussed, and examples of challenged books in the United States and Canada are provided, illustrating different reasons for censorship on both sides of the political and social spectrum. (AEF)

  15. Book Bonding.

    Science.gov (United States)

    Elleman, Barbara

    1998-01-01

    Discusses nine books (fiction, nonfiction, and poetry) for children that center on bats. Focuses on one book ("Silverwing") as an example of the animal fantasy genre, which can tell the adventures of a particular animal, impart environmental knowledge and concerns, and include intriguing, solid facts about the animal in question. Offers…

  16. Professional Books.

    Science.gov (United States)

    Gilstrap, Robert L.

    1994-01-01

    Reviews five books: "Garbage Pizza, Patchwork Quilts and Math Magic" (Ohanian), about elementary math instruction; "Ready for What?" (Graue), on school readiness; "The Braid of Literature: Children's Worlds of Reading" (Wolf and Heath); "The Best Years of Their Lives" (Zvirin), a book of resources for teenagers; and "Teaching and Learning in the…

  17. Book Reviews.

    Science.gov (United States)

    Powicke, J. C.; And Others

    1986-01-01

    Reviews of 10 recent books and one new journal ("Catalyst: A Journal of Policy Debate") are provided. Topics of the books reviewed include: economics in modern Britain, world economics, the mixed economy, Milton Friedman's thought, British industry, economic issues, and London as a financial center. (JDH)

  18. The 3rd Fermi GBM Gamma-Ray Burst Catalog: The First Six Years

    CERN Document Server

    Bhat, P Narayana; von Kienlin, Andreas; Paciesas, William S; Briggs, Michael S; Burgess, J Michael; Burns, Eric; Chaplin, Vandiver; Cleveland, William H; Collazzi, Andrew C; Connaughto, Valerie; Diekmann, Anne M; Fitzpatrick, Gerard; Gibby, Melissa H; Giles, Misty M; Goldstein, Adam M; Greiner, Jochen; Jenke, Peter A; Kippen, R Marc; Kouveliotou, Chryssa; Mailyan, Bagrat; McBreen, Sheila; Pelassa, Veronique; Preece, Robert D; Roberts, Oliver J; Sparke, Linda S; Stanbro, Matthew; Veres, Peter; Wilson-Hodge, Colleen A; Xiong, Shaolin; Younes, George; Yu, Hoi-Fung; Zhang, Binbin

    2016-01-01

    Since its launch in 2008, the Fermi Gamma-ray Burst Monitor (GBM) has triggered and located on average approximately two gamma-ray bursts (GRB) every three days. Here we present the third of a series of catalogs of GRBs detected by GBM, extending the second catalog by two more years, through the middle of July 2014. The resulting list includes 1405 triggers identified as GRBs. The intention of the GBM GRB catalog is to provide information to the community on the most important observables of the GBM detected GRBs. For each GRB the location and main characteristics of the prompt emission, the duration, peak flux and fluence are derived. The latter two quantities are calculated for the 50-300~keV energy band, where the maximum energy release of GRBs in the instrument reference system is observed, and also for a broader energy band from 10-1000 keV, exploiting the full energy range of GBM's low-energy NaI(Tl) detectors. Using statistical methods to assess clustering, we find that the hardness and duration of GRB...

  19. The 2nd Fermi GBM Gamma-Ray Burst Catalog: The First Four Years

    CERN Document Server

    von Kienlin, Andreas; Paciesas, William S; Bhat, P N; Bissaldi, Elisabetta; Briggs, Michael S; Burgess, J Michael; Byrne, David; Chaplin, Vandiver; Cleveland, William; Connaughton, Valerie; Collazzi, Andrew C; Fitzpatrick, Gerard; Foley, Suzanne; Gibby, Melissa; Giles, Misty; Goldstein, Adam; Greiner, Jochen; Gruber, David; Guiriec, Sylvain; van der Horst, Alexander J; Kouveliotou, Chryssa; Layden, Emily; McBreen, Sheila; McGlynn, Sinead; Pelassa, Veronique; Preece, Robert D; Rau, Arne; Tierney, Dave; Wilson-Hodge, Colleen A; Xiong, Shaolin; Younes, George; Yu, Hoi-Fung

    2014-01-01

    This is the second of a series of catalogs of gamma-ray bursts (GRBs) observed with the Fermi Gamma-ray Burst Monitor (GBM). It extends the first two-year catalog by two more years, resulting in an overall list of 953 GBM triggered GRBs. The intention of the GBM GRB catalog is to provide information to the community on the most important observables of the GBM detected GRBs. For each GRB the location and main characteristics of the prompt emission, the duration, peak flux and fluence are derived. The latter two quantities are calculated for the 50 - 300 keV energy band, where the maximum energy release of GRBs in the instrument reference system is observed and also for a broader energy band from 10 - 1000 keV, exploiting the full energy range of GBMs low-energy detectors. Furthermore, information is given on the settings and modifications of the triggering criteria and exceptional operational conditions during years three and four in the mission. This second catalog is an official product of the Fermi GBM sci...

  20. Implication of the association between GBM transient 150914 and LIGO Gravitational Wave event GW150914

    CERN Document Server

    Li, Xiang; Yuan, Qiang; Jin, Zhi-Ping; Fan, Yi-Zhong; Liu, Si-Ming; Wei, Da-Ming

    2016-01-01

    On September 14, 2015 the two detectors of LIGO simultaneously detected a transient gravitational-wave signal GW150914 and the Fermi GBM observations found a weak short gamma-ray burst (SGRB)-like transient (i.e., the GBM transient 150914). The time and location coincidences favor the association between GW150904 and GBM transient 150914. We compared GBM transient 150914 with other SGRBs and found that such an event is indeed a distinct outlier in the $E_{\\rm p,rest}-E_{\\rm iso}$ and $E_{\\rm p,rest}-L_{\\gamma}$ diagrams ($E_{\\rm iso}$ is the isotropic-equivalent energy, $L_\\gamma$ is the luminosity and $E_{\\rm p,rest}$ is the rest frame peak energy of the prompt emission), possibly due to its specific binary-black-hole merger origin. However, the presence of a "new" group of SGRBs with "low" $L_\\gamma$ and $E_{\\rm iso}$ but high $E_{\\rm p,rest}$ is also possible. If the outflow of GBM transient 150914 was launched by the accretion onto the nascent black hole, we estimate the accretion disk mass to be $\\sim 10...

  1. THE SECOND FERMI GBM GAMMA-RAY BURST CATALOG: THE FIRST FOUR YEARS

    Energy Technology Data Exchange (ETDEWEB)

    Von Kienlin, Andreas; Greiner, Jochen; Gruber, David [Max-Planck-Institut für extraterrestrische Physik, Giessenbachstrasse 1, D-85748 Garching (Germany); Meegan, Charles A.; Bhat, P. N.; Briggs, Michael S.; Burgess, J. Michael; Chaplin, Vandiver; Connaughton, Valerie; Goldstein, Adam [University of Alabama in Huntsville, 320 Sparkman Drive, Huntsville, AL 35805 (United States); Paciesas, William S.; Cleveland, William [Universities Space Research Association, 320 Sparkman Drive, Huntsville, AL 35805 (United States); Bissaldi, Elisabetta [Istituto Nazionale di Fisica Nucleare, Sezione di Trieste, I-34127 Trieste (Italy); Byrne, David; Fitzpatrick, Gerard; Foley, Suzanne [School of Physics, University College Dublin, Belfield, Stillorgan Road, Dublin 4 (Ireland); Collazzi, Andrew C. [Astrophysics Office, ZP 12, NASA-Marshall Space Flight Center, Huntsville, AL 35812 (United States); Gibby, Melissa; Giles, Misty [Jacobs Technology, Inc., Huntsville, AL 35806 (United States); Guiriec, Sylvain [NASA-Goddard Space Flight Center, Greenbelt, MD 20771 (United States); and others

    2014-03-01

    This is the second of a series of catalogs of gamma-ray bursts (GRBs) observed with the Fermi Gamma-ray Burst Monitor (GBM). It extends the first two-year catalog by two more years, resulting in an overall list of 953 GBM triggered GRBs. The intention of the GBM GRB catalog is to provide information to the community on the most important observables of the GBM detected GRBs. For each GRB the location and main characteristics of the prompt emission, the duration, peak flux and fluence are derived. The latter two quantities are calculated for the 50-300 keV energy band, where the maximum energy release of GRBs in the instrument reference system is observed and also for a broader energy band from 10-1000 keV, exploiting the full energy range of GBMs low-energy detectors. Furthermore, information is given on the settings and modifications of the triggering criteria and exceptional operational conditions during years three and four in the mission. This second catalog is an official product of the Fermi GBM science team, and the data files containing the complete results are available from the High-Energy Astrophysics Science Archive Research Center.

  2. An Unusual Case of Anti-GBM Antibody Elevation in HIV-Associated Nephropathy

    Directory of Open Access Journals (Sweden)

    Vinay Minocha

    2014-01-01

    Full Text Available Introduction. The most commonly seen glomerular disease in HIV infected patients is HIV-associated nephropathy (HIVAN; however, a multitude of other nephropathies can occur in HIV infection with an almost equal cumulative frequency. We report an unusual case of a patient with clinical and histological evidence of HIVAN in which the diagnosis was initially confounded by the finding of an elevated serum anti-glomerular basement membrane (anti-GBM antibody. Case Presentation. We present a case of a 27-year-old African American female with a history of schizophrenia, cocaine abuse, and HIV infection who upon admission to our hospital was found to have severe acute kidney injury requiring hemodialysis. Urine studies revealed nephrotic range proteinuria and a serological workup was positive for anti-GBM antibody elevation with a value of 91 units (normal: 0–20 units. A renal biopsy revealed HIVAN with no evidence of crescentic glomerulonephritis or anti-GBM disease. Conclusion. This case highlights the need for careful interpretation of anti-GBM antibody tests in HIV infected patients with kidney disease and, in particular, the need for biopsy confirmation of the diagnosis prior to starting therapy. More research is needed to study the prognostic correlation between the degree of anti-GBM antibody elevation in HIVAN and disease severity.

  3. 孙思邈《千金要方》针灸学术思想浅析%Academic Ideology of Acupuncture in the Book of Precious & Brief Prescription by SUN Si-miao

    Institute of Scientific and Technical Information of China (English)

    潘思安; 赵钊; 李成文; 卢享君; 常小荣

    2014-01-01

    The book Emergency Precious&Brief Prescription was written by Sun Si-miao in 652 A.D,and it was called as Precious &Brief Prescription for short,which included 30 volumes, 232 chapters, 5300 prescriptions,and this writing summarized the achievement of medical science prior to the Tang Dynasty systematically.It reflected the medical theory and experience of SUN,and the paper also recruited experience and theories of famous doctors in different dynasties such as GUO Yu,ZHANG Wen-zhong,FAN Wang as well.The substance it documented was both profound and methodical, which involved Internal, Surgery, Gynecology, Pediatrics, Features and other subjects.It also illustrated the information about acupuncture,massage,ChiKung,health preserving,food treatment and first aid thoroughly.Thousands of contents about acupuncture were mentioned,and in vol.29 and vol.30 acupuncture was discussed systematically and it was also mentioned in other volumes.This article summarized his academic ideology of acupuncture in aspects of prevention before treatment,incipient treatment; operation after sphygmus-check,prudent needling and moxibustion; choosing the best way,the best acupoint and the best medicine according to dialectics;suitable methods of moxibustion for different disea-ses;emphasizing the extra-acupoint and finding the Ashi acupoint;acupuncture prescription and guiding clinics,which laid a foundation for the further development of acupuncture and moxibustion of traditional Chinese medicine theory.%《备急千金要方》成书于公元652年,为唐代孙思邈所著,世人简称《千金要方》。全书共30卷,232门,合方论5300首,系统的总结了唐代以前的医学成就。不仅反映了孙氏的医学理论与临床经验,还收录了许多历代名医如郭玉、张文仲、范汪等的医学理论与经验。其内容载述广博、条理清晰,不仅涉及内、外、妇、儿、五官等临床各科,还对针灸、推拿、气功

  4. NEW BOOKS

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    4th Dalai Lama Yundain GyamcoAuthored by 5th Dalai Lama and translated by Chen Qingying and Ma Lianlong, the book tells the life of the 4th Dalai Lama who was the only non-Tibetan among the various generations of the Dalai Lama.As he was the first reincarnated Mongolian Living Buddha of the Gelug Sect, he held an important position in the history of the Gelug Sect. His period was a period filled with social changes, and little historical materials are found to cover his period. Publication of the book, published by the Tapei All Buddhist Cultural Undertakings Co. Ltd., is obviously a must-read book.

  5. The First Fermi Gamma-ray Burst Monitor (GBM) Terrestrial Gamma-ray Flash (TGF) Catalog

    Science.gov (United States)

    Briggs, Michael; Connaughton, Valerie; Stanbro, Matthew; Zhang, Binbin; Bhat, Narayana; Fishman, Gerald; Roberts, Oliver; Fitzpatrick, Gerard; McBreen, Shelia; Grove, Eric; Chekhtman, Alexandre

    2015-04-01

    We present summary results from the first catalog of Terrestrial Gamma-ray Flashes (TGFs) detected with the Gamma-ray Burst Monitor (GBM) on the Fermi Space Telescope. The catalog reports parameters for over 2700 TGFs. Since the launch of Fermi in 2008 the TGF detection sensitivity of GBM has been improved several times, both in the flight software and in ground analysis. Starting in 2010 July individual photons were downloaded for portions of the orbits, enabling an off-line search that found weaker and shorter TGFs. Since 2012 November 26 this telemetry mode has been extended to continuous coverage. The TGF sample is reliable, with cosmic rays rejected using data both from Fermi GBM and from the Large Area Telescope on Fermi. The online catalog include times (UTC and solar), spacecraft geographic positions, durations, count intensities and Bayesian Block durations. The catalog includes separate tables for bright TGFs detected by the flight software and for Terrestrial Electron Beams (TEBs).

  6. Earth Occultation Monitoring of the Hard X-ray/Low-Energy Gamma Ray Sky with GBM

    Science.gov (United States)

    Cherry, Michael L.; Camero-Arranz, A.; Case, G. L.; Chaplin, V.; Finger, M. H.; Jenke, P. A.; Rodi, J. C.; Wilson-Hodge, C. A.; GBM Earth Occultation Team

    2012-01-01

    By utilizing the Earth occultation technique (EOT), the Gamma-Ray Burst Monitor (GBM) instrument aboard Fermi has been used to make nearly continuous full-sky observations in the 8-1000 keV energy range. The GBM EOT analysis program currently monitors an input catalog containing 235 sources. We will present the GBM catalog of sources observed in the first 3 years of the EOT monitoring program, with special emphasis on the high energy (>100 keV) and time-variable sources, in particular the Crab, Cyg X-1, and A0535+26. We will also describe the initial results of an all-sky imaging analysis of the EOT data, with comparisons to the Swift, INTEGRAL, and Fermi LAT catalogs. This work is supported by the NASA Fermi Guest Investigator program, NASA/Louisiana Board of Regents, and Spanish Ministerio de Ciencia de Innovacion.

  7. The Fermi GBM and LAT follow-up of GW150914

    Directory of Open Access Journals (Sweden)

    Bissaldi E.

    2017-01-01

    Here we present observations by the Fermi Gamma-Ray BurstMonitor (GBM [1] and by the Large Area Telescope (LAT [2] of the LIGO Gravitational Wave event GW150914, which has been associated to the merger of two stellar-mass BHs. We report the presence of a weak transient event in GBM data, close in time to the LIGO one. We discuss the characteristics of this GBM transient, which are consistent with a weak short GRB arriving at a large angle to the direction in which Fermi was pointing. Furthermore, we report LAT upper limits (ULs for GW150914, and we present the strategy for follow-up observations of GW events with the LAT.

  8. Book Review:

    Science.gov (United States)

    Gregory, Ruth

    2007-06-01

    The study of braneworlds has been an area of intense activity over the past decade, with thousands of papers being written, and many important technical advances being made. This book focuses on a particular aspect of braneworlds, namely perturbative gravity in one specific model: the Randall-Sundrum model. The book starts with an overview of the Randall-Sundrum model, discussing anti-de Sitter (AdS) space and the Israel equations in some detail. It then moves on to discuss cosmological branes, focusing on branes with constant curvature. The book then turns to brane gravity, i.e. what do we, as brane observers, perceive the gravitational interaction to be on the brane as derived from the actual five-dimensional gravitational physics? After a derivation of the general brane equations from the Israel equations, the remainder of the book deals with perturbative gravity. This part of the book is extremely detailed, with calculations given explicitly. Overall, the book is quite pedagogical in style, with the aim being to explain in detail the topics it chooses to cover. While it is not unusual to have books written on current and extremely popular research areas, it is unusual to have calculations written so explicitly. This is both a strength and a weakness of this book. It is a strength because the calculations are presented in a detail that students learning the topic will definitely appreciate; however, the narrow focus of the book also means that it lacks perspective and fails to present the broader context. In choosing to focus on one particular aspect of Randall-Sundrum branes, the book has not managed to communicate why a large number of theorists have worked so intensively on this model. In its early stages, the explicit detail of the Randall-Sundrum model would be extremely useful for a student starting out in this research area. In addition, the calculational detail later in the computation of the graviton propagator on the brane would also be welcome not

  9. The Third Fermi GBM Gamma-Ray Burst Catalog: The First Six Years

    Science.gov (United States)

    Narayana Bhat, P.; Meegan, Charles A.; von Kienlin, Andreas; Paciesas, William S.; Briggs, Michael S.; Burgess, J. Michael; Burns, Eric; Chaplin, Vandiver; Cleveland, William H.; Collazzi, Andrew C.; Connaughton, Valerie; Diekmann, Anne M.; Fitzpatrick, Gerard; Gibby, Melissa H.; Giles, Misty M.; Goldstein, Adam M.; Greiner, Jochen; Jenke, Peter A.; Kippen, R. Marc; Kouveliotou, Chryssa; Mailyan, Bagrat; McBreen, Sheila; Pelassa, Veronique; Preece, Robert D.; Roberts, Oliver J.; Sparke, Linda S.; Stanbro, Matthew; Veres, Péter; Wilson-Hodge, Colleen A.; Xiong, Shaolin; Younes, George; Yu, Hoi-Fung; Zhang, Binbin

    2016-04-01

    Since its launch in 2008, the Fermi Gamma-ray Burst Monitor (GBM) has triggered and located on average approximately two γ-ray bursts (GRBs) every three days. Here, we present the third of a series of catalogs of GRBs detected by GBM, extending the second catalog by two more years through the middle of 2014 July. The resulting list includes 1405 triggers identified as GRBs. The intention of the GBM GRB catalog is to provide information to the community on the most important observables of the GBM-detected GRBs. For each GRB, the location and main characteristics of the prompt emission, the duration, peak flux, and fluence are derived. The latter two quantities are calculated for the 50-300 keV energy band where the maximum energy release of GRBs in the instrument reference system is observed, and also for a broader energy band from 10 to 1000 keV, exploiting the full energy range of GBM's low-energy [Nai[Tl)] detectors. Using statistical methods to assess clustering, we find that the hardness and duration of GRBs are better fit by a two-component model with short-hard and long-soft bursts than by a model with three components. Furthermore, information is provided on the settings and modifications of the triggering criteria and exceptional operational conditions during years five and six in the mission. This third catalog is an official product of the Fermi GBM science team, and the data files containing the complete results are available from the High-Energy Astrophysics Science Archive Research Center.

  10. Book Review

    Directory of Open Access Journals (Sweden)

    Adrian Brown

    2012-01-01

    Full Text Available The second edition of Computational Physics by Rubin Landau, Manuel Paez and Cristian C. Bordeianu (published by Wiley hit bookshelves in 2007, and is steadily making its way into physics classrooms across the United States. Your reviewer first encountered the book at the Stanford Campus Book Store, where it is presumably being put to good use by students and faculty. The first edition was published in 1997 with Landau and Paez as authors [Computational Physics, 1st edn, Wiley, New York, 1997]. Rubin Landau is a very experienced computational physicist and staff member of the Oregon State University in Corvallis, where he directs the Computational Physics for Undergraduates course and teaches using this book. Landau is an incredibly active teacher to put it mildly – the code for the book is supplied in an accompanying DVD and he also posts applets and video lectures for his courses on his web page (http://www.physics.orst.edu/~rubin/.

  11. Reviews: Books.

    Science.gov (United States)

    Weiss, Bretta; And Others

    1993-01-01

    Reviews three books: "The Schoolhome: Rethinking Schools for Changing Families," by Jane Martin; "Godly Play," by Jerome Berryman; and "Five Kingdoms: An Illustrated Guide to the Phyla of Life on Earth," by Margulis and Schwartz. (TJQ)

  12. Nightmare book

    Science.gov (United States)

    judithku; jajustin; tyler, d.

    2017-02-01

    In response to Kate Brown's review of Kate Moore's book The Radium Girls, which tells the depressing but important tale of female radium-dial painters in the early 1900s who contracted radiation poisoning.

  13. Book review

    African Journals Online (AJOL)

    questions enabling readers to consider how their organisation embodies each model. The ... discussed in detail and has more examples than other models in this book. ... theories and causes of organisational change and the second outlining ...

  14. Orange Book

    Data.gov (United States)

    U.S. Department of Health & Human Services — The Approved Drug Products with Therapeutic Equivalence (Orange Book or OB) is a list of drugs approved under Section 505 of the Federal Food, Drug and Cosmetic Act...

  15. Fermi GBM detects pulsations from Swift J0243.6+6124

    Science.gov (United States)

    Jenke, P.; Wilson-Hodge, C. A.

    2017-10-01

    On October 1, 2017, blind searches of Fermi GBM data detected strong pulsations from an unknown source with a pulse period of 4.927 seconds. Upon the Swift discovery of the new 9.86 second accreting NS, Swift J0243.6+6124 (ATeL #10809), the GBM pulsar project performed a dedicated search for pulsations around the pulse period of 9.86 seconds from the direction of Swift J0243.6+6124 starting September 01 through October 2, 2017.

  16. NEW BOOKS

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    CHINA'S SPACE TRAVEL On October 16, 2003 China successfully launched its first manned space flight. This book records the course of China's manned space undertaking, and development of its manned space flight. It includes 200 color plates relating to the Seven Systems of China's Manned Space Mission; Development of the Shenzhou Spacecraft; City of Dreams in the Gobi Desert; Yang Liwei-China's First Astronaut; and Chronology of the First Manned Space Flight. The book is appended with Memorabilia of China'...

  17. Book Reviews

    Directory of Open Access Journals (Sweden)

    Redactie KITLV

    2002-01-01

    Full Text Available -Stephen J. Appold, Heidi Dahles ,Tourism and small entrepreneurs; Development, national policy, and entrepreneurial culture: Indonesian cases. Elmsford, New York: Cognizant Communication Corporation, 1999, vi + 165 pp., Karin Bras (eds -Jean-Pascal Bassino, Peter Boothroyd ,Socioeconomic renovation in Vietnam; The origin, evolution and impact of Doi Moi. Singapore: Institute of Southeast Asian Studies, 2001, xv + 175 pp., Pham Xuan Nam (eds -Peter Boomgaard, Patrick Vinton Kirch, The wet and the dry; Irrigation and agricultural intensification in Polynesia. Chicago: The University of Chicago Press, 1994, xxii + 385 pp. -A.Th. Boone, Chr.G.F. de Jong, De Gereformeerde Zending in Midden-Java 1931-1975; Een bronnenpublicatie. Zoetermeer: Boekencentrum, 1997, xxiv + 890 pp. [Uitgaven van de Werkgroep voor de Geschiedenis van de Nederlandse Zending en Overzeese Kerken, Grote Reeks 6.] -Okke Braadbaart, Colin Barlow, Institutions and economic change in Southeast Asia; The context of development from the 1960s to the 1990s. Cheltenham: Edward Elgar, xi + 204 pp. -Freek Colombijn, Abidin Kusno, Behind the postcolonial; Architecture, urban space, and political cultures in Indonesia. London: Routledge, 2000, xiv + 250 pp. -Raymond Corbey, Michael O'Hanlon ,Hunting the gatherers; Ethnographic collectors, agents and agency in Melanesia, 1870s -1930s. Oxford: Bergahn Books, 2000, xviii + 286 pp. [Methodology and History in Anthropology 6.], Robert L. Welsch (eds -Olga Deshpande, Hans Penth, A brief histroy of Lan Na; Civilizations of North Thailand. Chiang Mai: Silkworm Books, 2000, v + 74 pp. -Aone van Engelenhoven, I Ketut Artawa, Ergativity and Balinese syntax. Jakarta: Badan Penyelenggaran Seri NUSA, Universitas Katolik Indonesia Atma Jaya, 1998, v + 169 pp (in 3 volumes. [NUSA Linguistic Studies of Indonesian and Other Languages in Indonesia 42, 43, 44.] -Rens Heringa, Jill Forshee, Between the folds; Stories of cloth, lives, and travels from Sumba

  18. Iowa Books for Young Adults Poll (Books for the Teenage Reader).

    Science.gov (United States)

    Conner, John W.

    1989-01-01

    Presents the results of the 1988 Books for Young Adults Poll. Includes the 31 most popular reading choices of Iowa and Illinois high school students. Provides brief summaries and publication information on books in the following categories: contemporary realism; historical fiction; science fiction; nonfiction; and adventure, mystery, suspense. (MM)

  19. BOOK MANAGER'S CHOICE BOOKS RECEIVED

    African Journals Online (AJOL)

    ... of higher cerebral functions like language, memory and problem solving. ... hormonal responses to exercise and the impact of these responses on different ... text to sports medicine. This book is not ... and classical music. He was widely read ...

  20. Electronic book – paperless book

    Directory of Open Access Journals (Sweden)

    Mateja Ločniškar-Fidler

    2003-01-01

    Full Text Available The article presents the electronic book, which is accessible on the Internet, with particularities and drawbacks that the present and future users and librarians may encounter.It also presents devices (such as scanners and hand-helds and software required for reading and designing electronic books, as well as the details we should pay attention to when buying and using the above mentioned devices. Some of the most significant web pages dedicated to the selling and promoting of electronic books are also presented. The protection of authors’ works, distributed via the Internet and digital media, is gaining importance. In September 1999, Slovenia also joined the international agreement on the protection of copyrights. It is expected that electronic books will gradually become part of the collection of all types of libraries. Therefore, libraries will need appropriate technical equipment as well as trained personnel for the usage of this new medium.

  1. Book Review:

    Science.gov (United States)

    Fulling, S. A.

    2006-05-01

    Witt's starting point. Chapter 35 covers Yang Mills fields and quantum gravity. The discussion of gravity is surprisingly brief, in view of DeWitt's lifelong preoccupation with that subject. One gathers that he came to accept that quantization of ordinary GR was a nonrenormalizable dead end and he did not feel able to delve into modern alternatives such as string theory. He rejects renormalizable fourth-order modifications of four-dimensional gravity because he could not stomach unfriendly ghosts (states of negative norm or unboundedly negative energy) nor the technical difficulties of integrating such theories into the functional-integral formalism (see pp 866 7). Finally, there is part VIII, entitled 'Examples. Simple Exercises in the Use of the Global Formalism'. It consists of 25 short chapters numbered separately from those of the main text. The preface recommends reading these and the main text in parallel. Most valuable in my opinion is a string of successively more complicated fermionic models, from which one can, with effort, come to understand the book's concern with anticommuting quantities. Hidden in an appendix (p 1001) is a crucial motivational paragraph: Super Hilbert spaces are generalizations of ordinary Hilbert spaces, designed so as to enable one to consider quantum systems with supernumber-valued parameters (e.g., a-type external sources) which, themselves, are introduced in order to present, in a compact algebraic way, certain relationships between real physical amplitudes. Real physics is restricted to the ordinary Hilbert space that fits inside the super Hilbert space. That is, anticommuting classical quantities (a-numbers) serve to fit anticommuting quantum fields naturally into the formalism of actions and functional integrals. Ultimately, the quantum theory of a conventional fermion field is expressible in the same spinors and Dirac matrices as before supersymmetry was invented. On the other hand, since products of two a-numbers are commuting objects

  2. Rituximab for the treatment of refractory simultaneous anti-glomerular basement membrane (anti-GBM) and membranous nephropathy.

    Science.gov (United States)

    Bandak, Ghassan; Jones, Bruce A; Li, Jian; Yee, Jerry; Umanath, Kausik

    2014-02-01

    Antibody-mediated anti-glomerular basement membrane (anti-GBM) disease occurs rarely in the presence of another B-cell disorder, membranous nephropathy. The coexistence of these two autoimmune disorders would be anticipated to require differing, specific therapies targeted to each disease process. We describe a case of concomitant membranous nephropathy and anti-GBM disease in which conventional therapy, including steroids, plasmapheresis and cyclophosphamide, failed to attenuate the anti-GBM disease, yet responded to an alternative treatment of rituximab. This B-cell directed, monoclonal, chimeric antibody treatment substantially reduced anti-GBM antibody titers and led to discontinuation of plasmapheresis, while maintaining the remission of membranous nephropathy and anti-GBM disease.

  3. Correlative Spectral Analysis of Gamma-Ray Bursts using Swift-BAT and GLAST-GBM

    CERN Document Server

    Stamatikos, Michael; Band, David L

    2008-01-01

    We discuss the preliminary results of spectral analysis simulations involving anticipated correlated multi-wavelength observations of gamma-ray bursts (GRBs) using Swift's Burst Alert Telescope (BAT) and the Gamma-Ray Large Area Space Telescope's (GLAST) Burst Monitor (GLAST-GBM), resulting in joint spectral fits, including characteristic photon energy (Epeak) values, for a conservative annual estimate of ~30 GRBs. The addition of BAT's spectral response will (i) complement in-orbit calibration efforts of GBM's detector response matrices, (ii) augment GLAST's low energy sensitivity by increasing the ~20-100 keV effective area, (iii) facilitate ground-based follow-up efforts of GLAST GRBs by increasing GBM's source localization precision, and (iv) help identify a subset of non-triggered GRBs discovered via off-line GBM data analysis. Such multi-wavelength correlative analyses, which have been demonstrated by successful joint-spectral fits of Swift-BAT GRBs with other higher energy detectors such as Konus-WIND ...

  4. Performance of two strategies for urgent ANCA and anti-GBM analysis in vasculitis

    NARCIS (Netherlands)

    de Joode, Anoek A. E.; Roozendaal, Caroline; van der Leij, Marcel J.; Bungener, Laura B.; Sanders, Jan Stephan; Stegeman, Coen A.

    2014-01-01

    Background: In anti-neutrophil cytoplasmic antibodies (ANCA) associated small vessel vasculitis (AAV), rapid testing for ANCA and anti-glomerular basement membrane (GBM) antibodies may be beneficial for therapeutic purpose. Objective: We analysed the diagnostic performance of two rapid ANCA and anti

  5. Implications of the Tentative Association between GW150914 and a Fermi-GBM Transient

    Science.gov (United States)

    Li, Xiang; Zhang, Fu-Wen; Yuan, Qiang; Jin, Zhi-Ping; Fan, Yi-Zhong; Liu, Si-Ming; Wei, Da-Ming

    2016-08-01

    The merger-driven gamma-ray bursts (GRBs) and their associated gravitational-wave (GW) radiation, if both are successfully detected, have some far-reaching implications, including, for instance: (i) the statistical comparison of the physical properties of the short/long-short GRBs with and without GW detection can test the general origin model; (ii) revealing the physical processes taking place at the central engine; (iii) measuring the velocity of the gravitational wave directly/accurately. In this work, we discuss these implications in the case of a possible association of GW150914/Gamma-ray Burst Monitor (GBM) transient 150914. We compared GBM transient 150914 with other SGRBs and found that such an event may be a distinct outlier in some statistical diagrams, possibly due to its specific binary black hole merger origin. However, the presence of a “new” group of SGRBs with “unusual” physical parameters is also possible. If the outflow of GBM transient 150914 was launched by the accretion onto the nascent black hole, the magnetic activity rather than the neutrino process is likely responsible for the energy extraction, and the accretion disk mass is estimated to be ˜10-5 M ⊙. The GW150914/GBM transient 150914 association, if confirmed, would provide the first opportunity to directly measure the GW velocity, and its departure from the speed of the light should be within a factor of ˜10-17.

  6. Earth Occultation Imaging of the Low Energy Gamma-Ray Sky with GBM

    CERN Document Server

    Rodi, J; Case, G L; Camero-Arranz, A; Chaplin, C; Finger, M H; Jenke, P; Wilson-Hodge, C A

    2013-01-01

    The Earth Occultation Technique (EOT) has been applied to Fermi's Gamma-ray Burst Monitor (GBM) to perform all-sky monitoring for a predetermined catalog of hard X-ray/soft gamma-ray sources. Imaging with a Differential filter using the Earth Occultation Method (IDEOM) has been developed to search for sources not in the catalog, thus completing the catalog and reducing a source of systematic error in EOT. IDEOM is a tomographic imaging method that takes advantage of the orbital precession of the Fermi satellite. Using IDEOM, all-sky images have been generated for ~4 years of GBM data in the 12-50 keV, 50-100 keV and 100-300 keV energy bands in search of sources otherwise unmodeled by the GBM occultation analysis. Analysis resulted in the detection of 43 sources in the 12-50 keV energy band, 23 sources in the 50-100 keV energy band, and 7 sources in the 100-300 keV energy band. IDEOM analysis has resulted in the addition of 16 sources to the GBM-EOT catalog. We also present the first joined averaged spectra fo...

  7. Book Review

    Science.gov (United States)

    Fritz, Steffen

    2017-07-01

    The book titled European Landscape Dynamics is a comprehensive compendium on the European CORINE land cover (CLC) and some other aspects such as fragmentation and ecosystem services in Europe. The authors constitute a wide selection of researchers and practitioners from across Europe active in this field. It contains 29 chapters of very different sizes ranging between 2 pages (Chapter 8) to 43 pages (Chapter 20). The book is structured in 5 different sections: 1. Introduction; 2. Methodology; 3. European CORINE data layers; 4. Case studies; and 5. CORINE Land Cover Perspective.

  8. Book Review

    Science.gov (United States)

    Mishchenko, Michael I.

    2016-08-01

    The main purpose of this exemplary book is to provide a systematic exposition of the entire field of optical tweezers and their applications. The book is divided into three (approximately equal) parts summarizing the electromagnetic theory of optical tweezers (Part I), the practice of designing and building optical tweezers (Part II), and extensive applications of optical tweezers in various branches of science (Part III). The exposition is highly methodical and addresses the needs of anyone dealing with optical tweezers, be it a theoretician, an engineer/experimentalist, a routine practitioner, or an interested scientist.

  9. MGMT inactivation and clinical response in newly diagnosed GBM patients treated with Gliadel.

    Science.gov (United States)

    Grossman, Rachel; Burger, Peter; Soudry, Ethan; Tyler, Betty; Chaichana, Kaisorn L; Weingart, Jon; Olivi, Alessandro; Gallia, Gary L; Sidransky, David; Quiñones-Hinojosa, Alfredo; Ye, Xiaobu; Brem, Henry

    2015-12-01

    We examined the relationship between the O(6)-methylguanine-methyltransferase (MGMT) methylation status and clinical outcomes in newly diagnosed glioblastoma multiforme (GBM) patients who were treated with Gliadel wafers (Eisai, Tokyo, Japan). MGMT promoter methylation has been associated with increased survival among patients with GBM who are treated with various alkylating agents. MGMT promoter methylation, in DNA from 122 of 160 newly diagnosed GBM patients treated with Gliadel, was determined by a quantitative methylation-specific polymerase chain reaction, and was correlated with overall survival (OS) and recurrence-free survival (RFS). The MGMT promoter was methylated in 40 (32.7%) of 122 patients. The median OS was 13.5 months (95% confidence interval [CI] 11.0-14.5) and RFS was 9.4 months (95% CI 7.8-10.2). After adjusting for age, Karnofsky performance score, extent of resection, temozolomide (TMZ) and radiation therapy (RT), the newly diagnosed GBM patients with MGMT methylation had a 15% reduced mortality risk, compared to patients with unmethylated MGMT (hazard ratio 0.85; 95% CI 0.56-1.31; p=0.46). The patients aged over 70 years with MGMT methylation had a significantly longer median OS of 13.5 months, compared to 7.6 months in patients with unmethylated MGMT (p=0.027). A significant difference was also found in older patients, with a median RFS of 13.1 versus 7.6 months for methylated and unmethylated MGMT groups, respectively (p=0.01). Methylation of the MGMT promoter in newly diagnosed GBM patients treated with Gliadel, RT and TMZ, was associated with significantly improved OS compared to the unmethylated population. In elderly patients, methylation of the MGMT promoter was associated with significantly better OS and RFS.

  10. Rituximab in anti-GBM disease: A retrospective study of 8 patients.

    Science.gov (United States)

    Touzot, Maxime; Poisson, Johanne; Faguer, Stanislas; Ribes, David; Cohen, Pascal; Geffray, Loic; Anguel, Nadia; François, Helene; Karras, Alexandre; Cacoub, Patrice; Durrbach, Antoine; Saadoun, David

    2015-06-01

    Anti-glomerular basement membrane (GBM) disease is a rare autoantibody-mediated disorder presenting as rapidly progressive glomerulonephritis, and often with pulmonary hemorrhage. Antibody removal with plasmapheresis and immunosuppressive drugs are the cornerstones of the treatment. Data regarding the use of specific B-cell depleting therapy such as rituximab are lacking. We conducted a retrospective observational study of 8 patients with severe and/or refractory GBM disease that received rituximab therapy. Eight patients (2 men, 6 women) with a mean age of 26 ± 13.1 years old were included. Seven had severe renal involvement [median creatinin level was 282 μmol/l, range (65-423)] requiring high immunosuppressive or plasmapheresis dependent, and two had relapse of pulmonary hemorrhage including one with renal failure. Patients received an initial immunosuppressive treatment including steroid and cyclosphosphamide (n = 8) and plasmapheresis (n = 5). Except one late relapse, rituximab therapy was started within two months after diagnosis. All patients except one received 4 weekly dose of rituximab (375 mg(2)). Anti-GBM antibodies were still present in 6/8 patients, at rituximab initiation. Complete remission was observed in 7 out of 8 patients, mostly 3 months after rituximab therapy. After a mean follow-up of 25.6 months (range 4-93), patient and renal survival were 100% and 75% respectively, but rituximab use did not improve GFR. Anti-GBM antibodies remained negative for all patients during follow-up. Only one patient developed a severe bacterial infection but no opportunistic or viral infections were reported. Rituximab may represent an additional and/or alternative therapy in the induction treatment of anti-GBM disease. Copyright © 2015 Elsevier Ltd. All rights reserved.

  11. CABOZANTINIB IS EFFECTIVE IN A SUBSET OF XENOGRAFT GBM TUMORS AND AFFECTS MULTIPLE SIGNALING PATHWAYS

    Science.gov (United States)

    Mikkelsen, Tom; deCarvalho, Ana C.; Arnold, Kimberly; Mueller, Claudius; Petricoin, Emanuel F; Poisson, Laila M.; Irtenkauf, Susan; Hasselbach, Laura

    2014-01-01

    BACKGROUND: (blind field). METHODS: Neurospheres enriched in CSCs were cultured from resected GBM tumors. Sensitivity to cabozantinib was determined in vitro. Cells were treated (IC40) in triplicate, and cell lysates were analyzed by reverse phase protein microarrays (RPPAs). GBM CSCs were implanted intracranially into nude mice. Cabozantinib was administered by oral gavage at a dose of 60 mg/kg for 4 weeks (5 days/week) as a single agent or in combination with 40 mg/kg TMZ. Tumor growth and response to treatment were monitored by non-invasive in vivo bioluminescence imaging (BLI) using the Xenogen IVIS System (Caliper Life Sciences), and overall survival. RESULTS: Sensitivity to cabozantinib treatment varied for the different GBM CSCs. From 70 proteins and phosphoproteins measured, 29 distributed among several signaling pathways were significantly altered after treatment in both resistant and sensitive GBM CSCs, including Met, Ret, AKT, MAPK/ERK. Cabozantinib single agent treatment reduced GBM tumor growth and increased mouse survival in two xenograft lines. Cabozantinib monotherapy reduced tumor size, as measured by BLI, but had no significant effect on overall survival for another xenograft line, however, the combination treatment resulted in sensitization of these xenografts to TMZ treatment. RPPA confirmed downregulation of the described targets for XL184, including activated Met, VEGFR2 and Ret (in vitro). CONCLUSIONS: Consistent with the clinical experience, both sensitive and resistant GBMs are represented in our CSC xenografts. More extensive evaluation will likely identify baseline biomarkers which might be valuable in identifying potentially sensitive sub-populations for subsequent clinical trials. RPPA and next-gen sequencing (NGS) on terminal tumors is underway. SECONDARY CATEGORY: Tumor Biology.

  12. Fermi GBM Observations of LIGO Gravitational-wave Event GW150914

    Science.gov (United States)

    Connaughton, V.; Burns, E.; Goldstein, A.; Blackburn, L.; Briggs, M. S.; Zhang, B.-B.; Camp, J.; Christensen, N.; Hui, C. M.; Jenke, P.; Littenberg, T.; McEnery, J. E.; Racusin, J.; Shawhan, P.; Singer, L.; Veitch, J.; Wilson-Hodge, C. A.; Bhat, P. N.; Bissaldi, E.; Cleveland, W.; Fitzpatrick, G.; Giles, M. M.; Gibby, M. H.; von Kienlin, A.; Kippen, R. M.; McBreen, S.; Mailyan, B.; Meegan, C. A.; Paciesas, W. S.; Preece, R. D.; Roberts, O. J.; Sparke, L.; Stanbro, M.; Toelge, K.; Veres, P.

    2016-07-01

    With an instantaneous view of 70% of the sky, the Fermi Gamma-ray Burst Monitor (GBM) is an excellent partner in the search for electromagnetic counterparts to gravitational-wave (GW) events. GBM observations at the time of the Laser Interferometer Gravitational-wave Observatory (LIGO) event GW150914 reveal the presence of a weak transient above 50 keV, 0.4 s after the GW event, with a false-alarm probability of 0.0022 (2.9σ). This weak transient lasting 1 s was not detected by any other instrument and does not appear to be connected with other previously known astrophysical, solar, terrestrial, or magnetospheric activity. Its localization is ill-constrained but consistent with the direction of GW150914. The duration and spectrum of the transient event are consistent with a weak short gamma-ray burst (GRB) arriving at a large angle to the direction in which Fermi was pointing where the GBM detector response is not optimal. If the GBM transient is associated with GW150914, then this electromagnetic signal from a stellar mass black hole binary merger is unexpected. We calculate a luminosity in hard X-ray emission between 1 keV and 10 MeV of {1.8}-1.0+1.5× {10}49 erg s-1. Future joint observations of GW events by LIGO/Virgo and Fermi GBM could reveal whether the weak transient reported here is a plausible counterpart to GW150914 or a chance coincidence, and will further probe the connection between compact binary mergers and short GRBs.

  13. microRNA expression pattern modulates temozolomide response in GBM tumors with cancer stem cells.

    Science.gov (United States)

    Tezcan, Gulcin; Tunca, Berrin; Bekar, Ahmet; Preusser, Matthias; Berghoff, Anna Sophie; Egeli, Unal; Cecener, Gulsah; Ricken, Gerda; Budak, Ferah; Taskapılıoglu, Mevlut Ozgur; Kocaeli, Hasan; Tolunay, Sahsine

    2014-07-01

    Temozolomide (TMZ) is widely used to treat glioblastoma multiforme (GBM). Although the MGMT gene methylation status is postulated to correlate with TMZ response, some patients with a methylated MGMT gene still do not benefit from TMZ therapy. Cancer stem cells (CSCs) may be one of the causes of therapeutic resistance, but the molecular mechanism underlying this resistance is unclear. microRNA (miRNA) deregulation has been recognized as another chemoresistance modulating mechanism. Thus, we aimed to evaluate the miRNA expression patterns associated with chemoresistance that is dependent on the CSC status in GBM tumors to identify therapeutic biomarkers. CSCs were identified in 5 of 20 patients' tumor tissues using magnetic separation. CSC (+) tumors displayed a significant induction of CpG island methylation in the MGMT gene promoter (p = 0.009). Using real-time reverse transcription polymerase chain reaction (qRT-PCR), 9 miRNAs related to GBM (mir-181b, miR-153, miR-137, miR-145, miR-10a, miR-10b, let-7d, miR-9, and miR-455-3p), which are associated with cell cycle and invasion was analyzed in tumor samples. Low miR-181b and high miR-455-3p expression levels were detected (p = 0.053, p = 0.004; respectively) in CSC (+) tumors. Analysis revealed a significant correlation between miR-455-3p expression and Smad2 protein levels as analyzed by immunohistochemistry in CSC (+) tumors (p = 0.002). Thus, miR-455-3p may be involved in TMZ resistance in MGMT methylated CSC (+) GBM patients. Further studies and evaluations are required, but this miRNA may provide novel therapeutic molecular targets for GBM treatment and new directions for the development of anticancer drugs.

  14. Book Review:

    Science.gov (United States)

    Botet, R.

    2004-09-01

    The second edition of Mathematical Methods for Physics and Engineering by Riley et al is a great scientific textbook. The reader should not be intimidated by its size - over 1200 pages - and skimming through it, one is confronted with a vast amount of information (which could be daunting for students). However, when reading it in detail one realizes that the number of pages is justified and the result is a self-contained reference on mathematical methods for physics. The book is well organized: it starts at basic university undergraduate level and progresses to the highest graduate level. It is a tour de force to write mathematical sections that are both complete and at a appropriate academic level; the sequence of sections (and their content) has been chosen with great care in order that each section may introduce the following ones. The authors have clearly succeeded with this challenge, making this a remarkable pedagogical book. No precise knowledge is needed at the beginning, and all the material is presented in a logical progression. The student can confidently follow the material as it is presented. Even though this book is devoted to physics and engineering, it can be used by students in other scientific fields. The material covered in the book concentrates on applied theorems and formulae. But as the title of the book indicates, it is primarily written 'for physics and engineering' so this is to be expected and it greatly simplifies the text of the course. Consequently, derivations of the main results are essentially 'for physicists'. Frequently proofs are briefly outlined and are not as detailed as many mathematicians would like. Nevertheless, the final results are always clearly stated together with the technical conditions under which they should be used, thus providing a very comprehensive and practical textbook. The only criticism is that the sections on probability and statistics do not fit comfortably between their previous and following sections

  15. Book Reviews.

    Science.gov (United States)

    Lance, Larry M.; And Others

    1987-01-01

    Reviews the following Human Sexuality books: "Taking Sides: Clashing Views on Controversial Issues in Human Sexuality" (Francoeur, R.T., 1987); "Annual Editions: Human Sexuality" (Pocs, O., 1987); "Personal Issues in Human Sexuality" (Gordon, S. and Snyder, W., 1986); "Journey Into Sexuality: An Exploratory Voyage" (Reiss, I.L., 1986); and…

  16. Book review

    NARCIS (Netherlands)

    NN,

    2003-01-01

    This book is entirely dedicated to the functional role of fungi in all kind of ecosystems, and it attempts to show how the world would function if fungi were not there. It is conceived as an introduction to the subject for students in mycology and ecology. The introductory chapters deal with fundame

  17. BOOKS JBOEKE

    African Journals Online (AJOL)

    tions of the survivors of the Coconut Grove fire disaster. Since then, every aspect of ... preface to the first edition, 'as any grown child knows, the quality of a book is in ... undertaken, and will be of particular value for preparation for postgraduate ...

  18. Electronic Books

    Science.gov (United States)

    Clyde, Laurel A.

    2005-01-01

    Terje Hillesund points out that "information technology and especially the Internet have profoundly changed the ways of publishing." Recently, the book publishing industry has started to catch up, making digitized texts--including multimedia texts--available for sale through online bookstores, and in some cases, available for free downloading.…

  19. Recommended Books

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    Book 1: (Editor-in-Chief: Shi Yafeng; Published by Elsevier and Science Press Beijing in 2008, 539 pages) Glaciers and Related Environments in China Since the professional institution for glaciology attached to the Chinese Academy of Sciences was established in 1958, studies of glaciers in alpine regions, and of Quaternary glaciations throughout

  20. Book review

    NARCIS (Netherlands)

    NN,

    2003-01-01

    This book is entirely dedicated to the functional role of fungi in all kind of ecosystems, and it attempts to show how the world would function if fungi were not there. It is conceived as an introduction to the subject for students in mycology and ecology. The introductory chapters deal with

  1. Book reviews

    NARCIS (Netherlands)

    NN,

    2004-01-01

    Since the publication of the first edition of this book, important developments in biotechnology and mushroom production made a new, revised version necessary. As it is written for the mushroom industry, it emphasizes on nutritional, medical, and cultivating aspects of edible and medicinal fungi. A

  2. Thin book

    DEFF Research Database (Denmark)

    En lille bog om teater og organisationer, med bidrag fra 19 teoretikere og praktikere, der deltog i en "Thin Book Summit" i Danmark i 2005. Bogen bidrager med en state-of-the-art antologi om forskellige former for samarbejde imellem teater og organisationer. Bogen fokuserer både på muligheder og...

  3. BOOK REVIEW

    Institute of Scientific and Technical Information of China (English)

    CHEN Shuaifeng; ZHANG Yun

    2011-01-01

    @@ The generic term"Chinese tradition"can be viewed from various perspectives.One thinks first of classic texts like The Four Books and The Five Classics,or the poetry of the Tang and the Song,as key parts of the genealogy of the "Chinese tradition."

  4. Book reviews

    NARCIS (Netherlands)

    NN,

    1961-01-01

    H.H. Allan, Flora of New Zealand. Vol. 1, 1961, liv + 1085 pp., 40 text figs., 4 end paper maps. Owen, Wellington. The author died in 1957; this volume, which contains the pteridophytes, gymnosperms, and dicots, was seen through the press by Lucy B. Moore. The book weighs no more than 560 grams, so

  5. Book fair

    CERN Multimedia

    2006-01-01

    The Swiss academic publishing house 'Presses Polytechniques Universitaires Romandes'will be presenting its most recent scientific and technical publications at a book fair in the lobby of the Main Building (60) from 10 a.m. to 4 p.m. on Thursday 28 September 2006.

  6. Book Reviews.

    Science.gov (United States)

    Joyner, Christopher C.; And Others

    1986-01-01

    Scholarly reviews of nine books are presented. Topics include nuclear deterrence, urban planning in France, human rights in the Republic of China, the United States' support of Israel, U. S. military policy, an analysis of Rousseau's social contract, political influences on the U. S. presidency, the state and political theory, and the loss of…

  7. Book reviews

    NARCIS (Netherlands)

    NN,

    2003-01-01

    The mycoflora of Nepal, a remote and not easily accessible country, has been poorly known so far. This book offers a welcome compilation of current knowledge, brought together by the author, and supplemented with his extensive own research. Introductory chapters deal with the phytogeography and

  8. Book Reviews.

    Science.gov (United States)

    Cole, Michael; And Others

    1993-01-01

    Reviews four books: (1) "On Intelligence. . .More or Less: A Bioecological Treatise on Intellectual Development" (Stephen J. Ceci); (2) "Knowing Children: Experiments in Conversation and Cognition" (Michael Siegal); (3) "Adolescents and Their Families: Paths of Ego Development" (S. T. Hauser and others); and (4) "Adolescence: An Anthropological…

  9. Book review

    African Journals Online (AJOL)

    up for the new scientific outlook that these elite readily covet was relegated to the ... ness: Culture, Ideology and Discourse, his book published as issue number 44 of .... It Would Take Time projects two categories of pantheons with the first ... rin's recent text is a piece of poetry, a work of drama or a short form of prose fiction.

  10. Book Review

    African Journals Online (AJOL)

    New York: Columbia ... ISBN: 978-0-231-13350-2 by Archana Barua. The Present Personal is a book of our time. .... Chapter 2 (“The Limits of Language and the Dream ..... Archana Barua has also published a number of poems and short.

  11. Book review

    African Journals Online (AJOL)

    There is considerable overlap between the prison poems in the first section ... with which the new book opens, 'The Following Dawn the Boots', talks about the first ... Two spir- ited efforts express solidarity with the executed Nigerian writer, Ken ...

  12. !Book review

    African Journals Online (AJOL)

    In view of the fact that Soko's book was published in 1994, this is a belated review. The ... in by the further sub-title /zibongo Zesingoni (Ngoni praise poetry). ... two praise poets who are mentioned in the first chapter should have been .... attracts almost the whole population which is keen to witness the crowning of its new.

  13. NEW BOOKS

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    Zhang Jingwu and Tibetan Liberation The Research Office of Party History of the Committee of the Tibet Autonomous Region edited this book. In the 1950s, Zhang Jingwu received orders to Tibet. He was designated as the representative of the Central Government

  14. Books Reviews

    OpenAIRE

    家本, 秀太郎

    1998-01-01

    Books Reviewed: "The Balance of Payments: Free Versus Fixed Exchange Rates"; "The Economics of Irrigation"; "Farmers and a Hungry World"; "French and EEC Grain Policies and Their Price Effects, 1920-1970"; "Growth and Structure in the Economy of Modern Italy"; "Production Yearbook 1966"; "The Cotton Industry: An Essay in American Economic History. Part I. The Cotton Culture and the Cotton Trade"

  15. NEW BOOKS

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    Selected Works on Historical Documents of Tibet (XXI);Collection of Journals on Tibetan Studies;Guidance to Traditional Architecture in Tibet;Concise History of Tibetan Music;Concise History of Tibetan Fine Arts;Series Books on Himalayas;Trekking in Tibet。

  16. Digital books.

    Science.gov (United States)

    Wink, Diane M

    2011-01-01

    In this bimonthly series, the author examines how nurse educators can use the Internet and Web-based computer technologies such as search, communication, and collaborative writing tools; social networking and social bookmarking sites; virtual worlds; and Web-based teaching and learning programs. This article describes digital books.

  17. Book notice

    NARCIS (Netherlands)

    Adema, Frits

    1999-01-01

    FOCKO WEBERLING & WILHELM TROLL: Die Infloreszenzen Band II, Teil 2, Monotele und polytele Synfloreszenzen. Gustav Fischer Verlag, Jena, Germany, 1998. 483 pp., illus. ISBN 3-437-35436-1. Price: DEM 238. A new volume in the monumental series of books on inflorescences in the tradition of Troll’s mor

  18. Book reviews

    NARCIS (Netherlands)

    NN,

    2004-01-01

    Since the publication of the first edition of this book, important developments in biotechnology and mushroom production made a new, revised version necessary. As it is written for the mushroom industry, it emphasizes on nutritional, medical, and cultivating aspects of edible and medicinal fungi. A

  19. Book Reviews.

    Science.gov (United States)

    Coates, Elizabeth; And Others

    1993-01-01

    Reviews three books: (1) "Jeux Populaires Traditionnels pour les Enfants d'aujourd'hui" (Traditional Popular Games for Today's Children) (Jacqueline Theriault and Denise Garon); "Early Childhood Education" (B. Persky and L. Golubchick, editors); and "Playing to Learn: The Young Child, Teacher and the Classroom" (Weininger and Daniel). (AC)

  20. Electronic Books

    Science.gov (United States)

    Clyde, Laurel A.

    2005-01-01

    Terje Hillesund points out that "information technology and especially the Internet have profoundly changed the ways of publishing." Recently, the book publishing industry has started to catch up, making digitized texts--including multimedia texts--available for sale through online bookstores, and in some cases, available for free downloading.…

  1. Book reviews

    NARCIS (Netherlands)

    NN,

    2003-01-01

    This book is dedicated to the world-known specialist in marine mycology, E. B. Gareth Jones on the occasion of his 65th birthday, for his substantial contribution to marine mycology. It contains 22 contributions by a multitude of authors, grouped around the central theme of Fungi in marine environme

  2. Book reviews

    NARCIS (Netherlands)

    NN,

    2004-01-01

    This book is a concise and rewritten version of the author’s ‘Anatomie der Hymenomyceten’, published in 1997 by Koeltz Verlag (CH), which, unfortunately, never has been reviewed in this journal. In almost 500 pages the author leads us through the exciting world of the anatomy, cytology, and histolog

  3. NEW BOOKS

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    CHINA'S SPACE TRAVEL On October 16, 2003 China successfully launched its first manned space flight. This book records the course of China's manned space undertaking, and development of its manned space flight. It includes 200 color plates relating to the Seven Systems of China's Manned Space Mission; Development of the Shenzhou Spacecraft; City of Dreams in the Gobi Desert; Yang

  4. NEW BOOKS

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    CHINA'S SPACE TRAVEL On October 16, 2003 China successfully launched its first manned space flight. This book records the course of China's manned space undertaking, and development of its manned space flight. It includes 200 color plates relating to the Seven Systems of China's Manned Space Mission; Development of the

  5. Book Reviews.

    Science.gov (United States)

    Eron, Leonard D.; And Others

    1994-01-01

    Reviews six books on developmental psychology: (1) "Children and Violence" (David Reiss and others); (2) "Television and the American Child" (George Comstock); (3) "Intellectual Development" (Robert Sternberg and Cynthia Berg); (4) "Context and Development" (Robert Cohen and Alexander Siegel); (5) "Adolescent Identity Formation" (Gerald Adams and…

  6. Book Reviews

    OpenAIRE

    Tauer, Loren; Dalrymple, Dana G.; Brink, Lars

    2004-01-01

    Books Reviewed include: A Comprehensive Assessment of the Role of Risk in US Agriculture by Just Richard E., Rulon D. Pope; Providing Global Public Goods: Managing Globalization by Inge Kaul, Pedro Conceicao, Katell Le Goulven and Ronald U. Mendoza; Agricultural Policy Reform-Politics and Process in the EU and US in the 1990s by Wayne Moyer and Tim Josling

  7. NEW BOOKS

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    CHINA’S SPACE TRAVEL On October 16, 2003 China successfully launched its first manned space flight. This book records the course of China’s manned space undertaking, and development of its manned space flight. It includes 200 color plates relating to the Seven Systems

  8. NEW BOOKS

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    Study of Nuns of Tibetan Buddhism Nuns constitute a part of members of Tibetan Buddhism. Recent years have seen more girls and women apply to be nuns. Studying the why and the female body of the members of Tibetan Buddhism is therefore of practical significance. Authored by Degyi Zholma, the book provides a panoramic description of nuns, including history and status quo. To write

  9. BOOK REVIEWS

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    This book by Professor Chen Yunü is a multi-faceted study of Buddhism during the Ming dynasty (1368-1644).The aim of the research as stated by the author is to clarify the social role of Buddhist institutions during that period and to explicate the "laicization" of Buddhism during the Ming (pp.30-31).

  10. Book Review:

    Science.gov (United States)

    Fallone, B. G.

    2004-01-01

    This book represents the proceedings of the five day programme on IMRT techniques presented at the 2003 American Association of Physicists in Medicine (AAPM) Summer School held in Colorado Springs, Colorado. The book is essentially an overview of IMRT techniques, discussing the history, the mathematical processes involved in the planning stages, the biological indices for evaluations, the off-line and on-line medical imaging that is required, the various IMRT delivery techniques available, positioning and motion verification, shielding and QA issues, and some clinical applications. There is some additional discussion on modulated electron and proton therapy, views on the clinical and financial impact of IMRT, as well as some speculation on the future uses of IMRT. The fact that the book is an `overview' must be emphasized. Medical physicists who are well-read in IMRT, or have implemented IMRT, even partially, may be a little disappointed with the book. Although specific details were purposely omitted, the well-read physicist would have preferred to go right to the `heart of the matter', something this book fails to do. As is typical of many proceedings-type books, there is a certain level of inconsistency of writing styles, as well as some redundancy between the different chapters. It is unfortunate that such a large volume does not have an index to allow a reader to explore a particular subject pertaining to IMRT. The reader would have to guide himself/herself by the table of contents before each chapter which could be a problem if the reader requires some information quickly. It is interesting to note that the book lends itself to a variety of professionals interested in IMRT, including administrators. It may be a source of help for medical physicists who wish to discuss IMRT issues with higher level administration, for example. Some clinical applications are also reviewed. The lack of details concerning the advantages of IMRT with respect to clinical outcome is

  11. TU-AB-BRA-11: Evaluation of Fully Automatic Volumetric GBM Segmentation in the TCGA-GBM Dataset: Prognosis and Correlation with VASARI Features

    Energy Technology Data Exchange (ETDEWEB)

    Rios Velazquez, E [Dana-Farber Cancer Institute | Harvard Medical School, Boston, MA (United States); Meier, R [Institute for Surgical Technology and Biomechanics, Bern, NA (Switzerland); Dunn, W; Gutman, D [Emory University School of Medicine, Atlanta, GA (United States); Alexander, B [Dana- Farber Cancer Institute, Brigham and Womens Hospital, Harvard Medic, Boston, MA (United States); Wiest, R; Reyes, M [Institute for Surgical Technology and Biomechanics, University of Bern, Bern, NA (Switzerland); Bauer, S [Institute for Surgical Technology and Biomechanics, Support Center for Adva, Bern, NA (Switzerland); Aerts, H [Dana-Farber/Brigham Womens Cancer Center, Boston, MA (United States)

    2015-06-15

    Purpose: Reproducible definition and quantification of imaging biomarkers is essential. We evaluated a fully automatic MR-based segmentation method by comparing it to manually defined sub-volumes by experienced radiologists in the TCGA-GBM dataset, in terms of sub-volume prognosis and association with VASARI features. Methods: MRI sets of 67 GBM patients were downloaded from the Cancer Imaging archive. GBM sub-compartments were defined manually and automatically using the Brain Tumor Image Analysis (BraTumIA), including necrosis, edema, contrast enhancing and non-enhancing tumor. Spearman’s correlation was used to evaluate the agreement with VASARI features. Prognostic significance was assessed using the C-index. Results: Auto-segmented sub-volumes showed high agreement with manually delineated volumes (range (r): 0.65 – 0.91). Also showed higher correlation with VASARI features (auto r = 0.35, 0.60 and 0.59; manual r = 0.29, 0.50, 0.43, for contrast-enhancing, necrosis and edema, respectively). The contrast-enhancing volume and post-contrast abnormal volume showed the highest C-index (0.73 and 0.72), comparable to manually defined volumes (p = 0.22 and p = 0.07, respectively). The non-enhancing region defined by BraTumIA showed a significantly higher prognostic value (CI = 0.71) than the edema (CI = 0.60), both of which could not be distinguished by manual delineation. Conclusion: BraTumIA tumor sub-compartments showed higher correlation with VASARI data, and equivalent performance in terms of prognosis compared to manual sub-volumes. This method can enable more reproducible definition and quantification of imaging based biomarkers and has a large potential in high-throughput medical imaging research.

  12. SU-C-BRE-03: Dual Compartment Mathematical Modeling of Glioblastoma Multiforme (GBM)

    Energy Technology Data Exchange (ETDEWEB)

    Yu, V; Nguyen, D; Kupelian, P; Kaprealian, T; Selch, M; Low, D; Pajonk, F; Sheng, K [UCLA, Los Angeles, CA (United States)

    2014-06-15

    Purpose: To explore the aggressive recurrence and radioresistence of GBM with a dual compartment tumor survival mathematical model based on intrinsic tumor heterogeneity, cancer stem cells (CSC) and differentiated cancer cells (DCC). Methods: The repopulation and differentiation responses to radiotherapy of a solid tumor were simulated using an Ordinary Differential Equation (ODE). To obtain the tumor radiobiological parameters, we assumed that a tumor consists of two subpopulations, each with its distinctive linear quadratic parameters. The dual compartment cell survival model was constructed as SF(D)=F × exp(-α{sub 1} D-β{sub 1}D{sup 2}) + (1-F) × exp(-α{sub 2}D-β{sub 2}D{sup 2}) for a single fraction of treatment, with F as the fraction of CSC, and α and β describing the radiological properties of each population. Robust least square fitting was performed on clonogenic survival data from one GBM (U373MG) and one NSCLC (H460) cell line. The fit parameters were then used in the ODE model to predict treatment outcome of various treatment schemes. Results: The fit parameters from GBM cell survival data were (F, α{sub 1}, β{sub 1}, α{sub 2}, β{sub 2})=(0.0396, 0.0801, 0.0006, 0.1363, 0.0279), exhibiting two populations with distinctive radiological properties, CSC more radioresistant than DCC. The GBM cell line exhibited significantly poorer tumor control than its single compartment model prediction and NSCLC, which responded well to hypofrationation. The increased radioresistance was due to rapid regrowth of the DCC compartment triggered by its depletion while maintaining a viable CSC population. The rapid regrowth can be reduced by treating dose fractions ≤ 2 Gy with a prolonged treatment period. Conclusion: The interaction between a radioresistant CSC compartment and DCC compartment can explain the poor clinical outcome of GBM after radiotherapy despite dose escalation and hypofractionation attempts. Lower dose fractions result in better treatment

  13. BOOK REVIEW: Supergravity Supergravity

    Science.gov (United States)

    Gregory, Ruth

    2013-02-01

    Supergravity is an essential ingredient in so many areas of ultra high energy physics, yet it is rarely taught systematically, even at the graduate level. Students most often have to learn along with applying, and must use the now classic older texts. For such core material, it is surprising that there are so few good texts on the subject. It is not necessarily that supergravity is so much more conceptually complex, rather that it is technical and therefore easy for a text to become dry, dense and rather indigestible. This book, written by two experts in the field, is therefore a breath of fresh air. It not only represents a comprehensive modern overview of the subject, but achieves this with clarity, accessibility, and even humour! To paraphrase the authors, if you are not impressed by this book, you should put it down and watch television instead. It starts by reviewing, or overviewing, aspects of field theory, basic supersymmetry and gravity that will be needed for the rest of the book. This first third or so of the book is very condensed, and will not be easy to follow for those who have not encountered the material before. However, the authors acknowledge this and give plenty of suggestions for more pedagogical texts in the relevant areas, thus it does not feel overly brief. The middle section deals with the construction of supergravity, starting with basic N = 1 supergravity in 4 and 11 dimensions and gradually extending the discussion to include matter multiplets. This part of the book systematically builds up understanding and construction of models, before moving on to superconformal methods. The purpose is not to cover all supergravity theories, but to focus on a few examples in detail, and to give sufficient expertise and information for the reader to be able to deal with any other models they might need. The final part of the book deals with applications, and includes two chapters on applications in adS/CFT, which will be of most interest to new

  14. Book Review

    Directory of Open Access Journals (Sweden)

    Peralam Yegneswaran Prakash

    2016-08-01

    Full Text Available Since its primary release in 1992 and a second version in 2007 the book ‘Descriptions of Medical Fungi’ has been impressively advanced in its utility for identification of fungi. The initial editions of this book titled ‘Descriptions of Medical QAP Fungi’ were prepared as description sheets to facilitate identification of fungi at participant laboratories in the Royal College of Pathologists of Australasia (RCPA Mycology Quality Assurance Program (QAP. Keeping pace with the major shifts in fungal nomenclature, an updated and refurbished third edition is now available. The authors have attempted to reconcile and portray the present-day morphological description of medically important fungi with supplementary phylogenetic studies.

  15. Book Review

    Science.gov (United States)

    Tanona, Scott

    There is more to this book than readers of this journal might expect from an author who has associated Bohr and Heisenberg with Derrida and Lacan (Plotnitsky, 1994, 2002). Plotnitsky has written in the past on trying to bridge the "two cultures" of the "science wars" by defending Derrida and others against what he perceives to have been too-quickly dismissive critiques (Plotnitsky, 1997), but he has not provided an extended philosophical analysis of Bohr to support the connections he has made. This book seems to be an attempt to engage in a careful analysis of Bohr in a way meant to satisfy critical readers and also support what he here calls "nonclassical epistemology".

  16. Book review

    Directory of Open Access Journals (Sweden)

    Agnieszka Szefer

    2012-10-01

    Full Text Available Sally Meets Harry: Practical Primer to English Pronunciation and Spelling Author: Marta Nowacka, Piotr Cymbalista and Grzegorz A. Kleparski Publisher: Wydawnictwo Uniwersytetu Rzeszowskiego ISBN: 978-837-33867-3-0 Pages: 208;How Much Wood Would a Woodchuck Chuck?’ English Pronunciation Practice Book Author: Anna Mańkowska, Marta Nowacka and Magdalena Kłoczowska Publisher: Konsorcjum Akademickie ISBN: 978-839-28763-2-8 Pages: 200.

  17. Book Review

    Directory of Open Access Journals (Sweden)

    Salvatore Filippone

    2014-01-01

    Full Text Available The book by Arjen Markus is a veritable tour de force among the possibilities opened up by the latest incarnation of Fortran, the longest-lived programming language on the planet and still one of the favourites by scientific programmers. It is not an introduction to the syntax and semantics of the latest language standard: it is more of a gourmet cookbook showing off a wide range of examples of what the new features allow a daring programmer to do.

  18. Book Reviews

    OpenAIRE

    Adrianus Koster; Peter Gathercole; Simon Kooijman; Roland Werner; P.E. de Josselin de Jong; John Ingleson; C.K. Jonker-de Putter; M. Jacq-Hergoualc’h; R. Hagesteijn; William Wood; B.G. Grijpstra; Robert Wessing; D.C. Geirnaert-Martin; Carl Lumholtz; P. van Emst

    1981-01-01

    - H.J.M. Claessen, David Lewis, From Maui to Cook: The discovery and settlement of the Pacific, Drawings by Walter Stackpool. Sydney: Doubleday, 1977. Bibliography. - P. van Emst, Carl Lumholtz, Among Cannibals. An account of four years travel in Australia and of camp life with the aborigines of Queensland. Firle: Caliban Books. 383 pp. Maps, illustrations and index. Reprinted from the first edition, London: John Murray. - D.C. Geirnaert-Martin, Robert Wessing, Cosmology and social behaviour ...

  19. Book Information

    Institute of Scientific and Technical Information of China (English)

    Li; Caige

    2015-01-01

    The Cultural Gene of Ancient Chinese SpaceAuthor:Zhang Jie Year:2012Publisher:Tsinghua University Press ISBN:9787302273646(413 pages,in Chinese)From multiple perspectives of ancient astronomy,cultural geography and mountain modes,etiquette culture and system,artifacts and space archaeology,traditional painting,geomantic theory,etc.,this book systematically explores the main origins,concepts,con-

  20. NEW BOOKS

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    CHINA'S SPACE TRAVEL On October 16, 2003 China successfully launched its first manned space flight. This book records the course of China's manned space undertaking, and development of its manned space flight. It includes 200 color plates relating to the Seven Systems of China's Manned Space Mission; Development of the Shenzhou Spacecraft; City of Dreams in the Gobi Desert; Yang Liwei-China's First Astronaut; and Chronology of the First

  1. Book Information

    Institute of Scientific and Technical Information of China (English)

    Qian; Fang

    2015-01-01

    Worlding Cities:Asian Experiments anthe Art of Being Global Author:Ananya Roy;Editor:Aihwa Ong Year:2012Publisher:Wiley-Blackwell ISBN:1405192763(376 pages,in English)From Dubai to Delhi and from Singapore to Shanghai,cities across Asia are sites of intense experiments with different ways of being global.This book intervenes in urban theory focused on established

  2. Book Review:

    Science.gov (United States)

    Truscott, J. G.

    2004-05-01

    A book of this nature is long overdue; as could be expected from the pedigree of the editors, the coverage is comprehensive and, thanks to the authors selected, is of high quality. The book is divided into five sections, the central three of which are concerned with the measurement techniques themselves. The invasive techniques of mechanical testing and bone histology are dealt with in great detail at a level suitable for postgraduate students looking for an introduction to these techniques at a practical level. In the section dealing with the measurement techniques which use ionizing radiation, the chapters on DXA, neutron activation and radiogrammetry are well detailed and again at the appropriate level for postgraduate students. However, the chapters dealing with quantitative CT techniques are missing the sort of information that would have given them more authority. There is no mention of reconstruction algorithms or some of the typical shortcomings (e.g. partial volume artefacts) of these techniques and, given the excellent quality of the rest of the book, this was disappointing. The third of these technique sections deals with methods that do not use ionizing radiation. As one might expect with these two editors, the chapter on ultrasound is excellent and the coverage thorough and deep. The chapter on MRI and bone is particularly useful and timely as little has been published in this area and the debate about how best to measure bone quality in vivo has recently been rejoined. The chapters on finite element modelling and vibration analysis give a useful overview of the topics and have comprehensive reference lists for anyone who wishes to deepen their studies. The book has a useful introductory section. Bone biology is discussed in some detail, providing sufficient knowledge for the reader to be able to understand the basis and significance of the measurement techniques that follow. Exhaustive coverage is given to biological and radiation safety issues which

  3. The Successful Synergy of Swift and Fermi/GBM in Magnetars

    Science.gov (United States)

    Kouveliotou, Chryssa

    2011-01-01

    The magnetar rate of discovery has increased dramatically in the last decade. Five sources were discovered in the last three years alone as a result of the very efficient synergy among three X- and .gamma-ray instruments on NASA satellites: the Swift/Burst Alert Telescope (BAT), the Fermi/Gamma ray Burst Monitor (GBM), and the Rossi X-Ray Timing Explorer; RXTE/Proportional Counter Array (PCA). To date, there are approx. 25 magnetar candidates, of which two are (one each) in the Large and Small Magellanic Cloud and the rest reside on the Galactic plane of our Milky Way. I will discuss here the main properties of the Magnetar Population and the common projects that can be achieved with the synergy of Swift and GBM.

  4. Searching for Unmodeled Sources Using the Earth Occultation Data from the Fermi GBM

    CERN Document Server

    Rodi, James; Cherry, Michael L; Camero-Arranz, Ascension; Finger, Mark H; Jenke, Peter; Wilson-Hodge, Colleen A; Chaplin, Vandiver

    2011-01-01

    Employing the 12 NaI detectors in the Fermi GBM, the Earth Occultation Technique (EOT) can be used to measure the fluxes of x-ray and gamma-ray sources. Each time a source passes behind the Earth (or emerges from behind the Earth), a step-like feature is produced in the detector count rate. With a predefined catalog of source positions, the times of the occultation steps can be calculated, the individual steps fit, and the fluxes derived. However, in order to find new sources and generate a complete catalog, a method is needed for generating an image of the sky. An imaging algorithm has been developed to generate all-sky images using the GBM data. Here we present imaging results from ~2.5 years of data in the 12-25 keV and 100-300 keV energy bands.

  5. THE FERMI GBM GAMMA-RAY BURST SPECTRAL CATALOG: THE FIRST TWO YEARS

    Energy Technology Data Exchange (ETDEWEB)

    Goldstein, Adam; Burgess, J. Michael; Preece, Robert D.; Briggs, Michael S.; Guiriec, Sylvain; Connaughton, Valerie; Paciesas, William S.; Bhat, P. N.; Chaplin, Vandiver [Physics Department, University of Alabama in Huntsville, 320 Sparkman Drive, Huntsville, AL 35805 (United States); Van der Horst, Alexander J.; Meegan, Charles A. [Universities Space Research Association, 320 Sparkman Drive, Huntsville, AL 35805 (United States); Wilson-Hodge, Colleen A.; Fishman, Gerald J. [Space Science Office, VP62, NASA/Marshall Space Flight Center, Huntsville, AL 35812 (United States); Von Kienlin, Andreas; Bissaldi, Elisabetta; Diehl, Roland; Foley, Suzanne [Max-Planck-Institut fuer extraterrestrische Physik, Giessenbachstrasse 1, 85748 Garching (Germany); Fitzpatrick, Gerard [School of Physics, University College Dublin, Belfield, Stillorgan Road, Dublin 4 (Ireland); Gibby, Melissa; Giles, Misty [Jacobs Technology, 1500 Perimeter Parkway, Huntsville, AL 35806 (United States); and others

    2012-03-01

    We present systematic spectral analyses of gamma-ray bursts (GRBs) detected by the Fermi Gamma-Ray Burst Monitor (GBM) during its first two years of operation. This catalog contains two types of spectra extracted from 487 GRBs, and by fitting four different spectral models, this results in a compendium of over 3800 spectra. The models were selected based on their empirical importance to the spectral shape of many GRBs, and the analysis performed was devised to be as thorough and objective as possible. We describe in detail our procedure and criteria for the analyses, and present the bulk results in the form of parameter distributions. This catalog should be considered an official product from the Fermi GBM Science Team, and the data files containing the complete results are available from the High-Energy Astrophysics Science Archive Research Center.

  6. Book Review:

    Science.gov (United States)

    Beenakker, C. W. J.

    2005-08-01

    Quantum Noise is advertised as a handbook, and this is indeed how it functions for me these days: it is a book that I keep within hand's reach, ready to be consulted on the proper use of quantum stochastic methods in the course of my research on quantum dots. I should point out that quantum optics, the target field for this book, is not my field by training. So I have much to learn, and find this handbook to be a reliable and helpful guide. Crispin Gardiner previously wrote the Handbook of Stochastic Methods (also published by Springer), which provides an overview of methods in classical statistical physics. Quantum Noise, written jointly with Peter Zoller, is the counterpart for quantum statistical physics, and indeed the two books rely on each other by frequent cross referencing. The fundamental problem addressed by Quantum Noise is how the quantum dynamics of an open system can be described statistically by treating the environment as a source of noise. This is a general problem in condensed matter physics (in particular in the context of Josephson junctions) and in quantum optics. The emphasis in this book in on the optical applications (for condensed matter applications one could consult Quantum Dissipative Systems by Ulrich Weiss, published by World Scientific). The optical applications centre around the interaction of light with atoms, where the atoms represent the open system and the light is the noisy environment. A complete description of the production and detection of non-classical states of radiation (such as squeezed states) can be obtained using one of the equivalent quantum stochastic formulations: the quantum Langevin equation for the field operators (in either the Ito or the Stratonovich form), the Master equation for the density matrix, or the stochastic Schrödinger equation for the wave functions. Each formulation is fully developed here (as one would expect from a handbook), with detailed instructions on how to go from one to the other. The

  7. The Interplanetary Network Supplement to the Fermi GBM Catalog of Cosmic Gamma-Ray Bursts

    CERN Document Server

    Hurley, K; Aptekar, R L; Golenetskii, S V; Frederiks, D D; Mazets, E P; Svinkin, D S; Briggs, M S; Connaughton, V; Meegan, C; Goldsten, J; Boynton, W; Fellows, C; Harshman, K; Mitrofanov, I G; Golovin, D V; Kozyrev, A S; Litvak, M L; Sanin, A B; Rau, A; von Kienlin, A; Zhang, X; Yamaoka, K; Fukazawa, Y; Hanabata, Y; Ohno, M; Takahashi, T; Tashiro, M; Terada, Y; Murakami, T; Makishima, K; Barthelmy, S; Cline, T; Gehrels, N; Cummings, J; Krimm, H A; Smith, D M; Del Monte, E; Feroci, M; Marisaldi, M

    2013-01-01

    We present Interplanetary Network (IPN) data for the gamma-ray bursts in the first Fermi Gamma-Ray Burst Monitor (GBM) catalog. Of the 491 bursts in that catalog, covering 2008 July 12 to 2010 July 11, 393 were observed by at least one other instrument in the 9-spacecraft IPN. Of the 393, the localizations of 146 could be improved by arrival time analysis (or "triangulation"). For any given burst observed by the GBM and one other distant spacecraft, triangulation gives an annulus of possible arrival directions whose half-width varies between about 0.4 arcminutes and 32 degrees, depending on the intensity, time history, and arrival direction of the burst, as well as the distance between the spacecraft. We find that the IPN localizations intersect the 1 sigma GBM error circles in only 52% of the cases, if no systematic uncertainty is assumed for the latter. If a 6 degree systematic uncertainty is assumed and added in quadrature, the two localization samples agree about 87% of the time, as would be expected. If ...

  8. Best Books 1982.

    Science.gov (United States)

    School Library Journal, 1982

    1982-01-01

    This annotated bibliography lists 45 children's books and 29 young adult books selected by School Library Journal's Book Review staff and Young Adult Review committee, respectively. Arrangement is alphabetical by author with the grade level indicated for children's books. (EJS)

  9. The Cross-Calibration of Swift-BAT and Fermi-GBM via Correlative Spectral Analysis of GRBs

    CERN Document Server

    Stamatikos, Michael

    2009-01-01

    We report on recent inter-calibration studies featuring Swift's Burst Alert Telescope (BAT) and Fermi's Gamma-ray Burst Monitor (GBM) based upon correlated observations of GRBs 080804 and 080810, via their resultant joint spectral analysis. Swift's intrinsic multi-wavelength instrumentation and dynamical response complement Fermi's superior energy range. The addition of BAT's spectral response will (i) facilitate in-orbit GBM detector response calibration, (ii) augment Fermi's low energy sensitivity, (iii) enable ground-based follow-up efforts of Fermi GRBs, and (iv) help identify a subset of GRBs discovered via off-line GBM data analysis, for an annual estimate of ~30 GRBs. The synergy of BAT and GBM augments previous successful joint spectral fit efforts by enabling the study of peak photon energies (Epeak), while leveraging the over eleven energy decades afforded by Fermi's Large Area Telescope (LAT), in conjunction with Swift's X-Ray (XRT) and Ultraviolet-Optical (UVOT) Telescopes, for an unprecedented pr...

  10. Book Review:

    Science.gov (United States)

    Vespignani, A.

    2004-09-01

    Networks have been recently recognized as playing a central role in understanding a wide range of systems spanning diverse scientific domains such as physics and biology, economics, computer science and information technology. Specific examples run from the structure of the Internet and the World Wide Web to the interconnections of finance agents and ecological food webs. These networked systems are generally made by many components whose microscopic interactions give rise to global structures characterized by emergent collective behaviour and complex topological properties. In this context the statistical physics approach finds a natural application since it attempts to explain the various large-scale statistical properties of networks in terms of local interactions governing the dynamical evolution of the constituent elements of the system. It is not by chance then that many of the seminal papers in the field have been published in the physics literature, and have nevertheless made a considerable impact on other disciplines. Indeed, a truly interdisciplinary approach is required in order to understand each specific system of interest, leading to a very interesting cross-fertilization between different scientific areas defining the emergence of a new research field sometimes called network science. The book of Dorogovtsev and Mendes is the first comprehensive monograph on this new scientific field. It provides a thorough presentation of the forefront research activities in the area of complex networks, with an extensive sampling of the disciplines involved and the kinds of problems that form the subject of inquiry. The book starts with a short introduction to graphs and network theory that introduces the tools and mathematical background needed for the rest of the book. The following part is devoted to an extensive presentation of the empirical analysis of real-world networks. While for obvious reasons of space the authors cannot analyse in every detail all the

  11. Book Review:

    Science.gov (United States)

    Fabris, Júlio C.

    2004-04-01

    General relativity is one of the cornerstones of modern physics. In spite of this, the teaching of general relativity at undergraduate level remains quite marginal. The reasons for this particular situation are quite well known. We can quote, for example, two of them: general relativity requires specific mathematical tools that are somehow outside the mainstream of undergraduate technical development; moreover, this is a branch of physics whose observational and experimental applications have remained rare until recent times, and even though this scenario has changed dramatically in the last few years, the new situation has not yet been absorbed into undergraduate teaching. However, there are many textbooks devoted to the teaching of general relativity at undergraduate level. The recent book of J B Hartle, Gravity: An Introduction to Einstein's General Relativity, is a new proposal in this sense. It is perhaps one of the most interesting pedagogical approaches seeking to surmount the difficulties that arise when one tries to include general relativity in undergraduate teaching. In this new book, Hartle attempts to address the difficuties that must be faced by anyone who teaches general relativity at undergraduate level. In order to not scare the student with the hard technical preparation needed to obtain the basic equations of general relativity, Einstein's equations, he simply gives up the idea of introducing these equations at the very beginning. Instead, he chooses to present Einstein's equations, with most of the mathematics needed to do them, in the last part of the book. This delicate (and of course dangerous) choice has the advantage of introducing the reader first to the physical aspects of general relativity. This approach can be dangerous because the relevant solutions of the equations necessary to discuss the physical content of general relativiy are presented first without a formal derivation. But the author circumvents this potential drawback in a

  12. Book Reviews

    Directory of Open Access Journals (Sweden)

    Cyril Skinner

    1968-10-01

    Full Text Available - Soebardi, Poerwanto Danoesoegondo, Bahasa Indonesia for beginners. Sydney University Press, 1966, Book I, 160 pp. - Soebardi, J.P. Sarumpaet, The structure of bahasa Indonesia. Department of Indonesian and Malayan Studies, University of Melbourne, 1966, 167 pp. Off-set Print. - Soebardi, J.P. Sarumpaet, Introduction to Bahasa Indonesia. Melbourne University Press, 1967, 111 pp., J.A.C. Mackie (eds. - Soebardi, T.S. Lie, Introducing Indonesian. Sydney, Angus & Robertson Ltd. Book I, 1965, 115 pp. Book II, 1966, 184 pp. - A. Teeuw, Joseph Verguin, Le Malais. Essai d’analyse fonctionnelle et structurale. Cahiers de l’Homme, Ethnologie - Géographie - Linguistique. Nouvelle Série VII. Mouton & Co. Paris, La Haye 1967, 146 pp. - R. Roolvink, Cyril Skinner, The civil war in Kelantan in 1839. Monographs of the Malaysian Branch of the Royal Asiatic Society, II, 1965. vii, 175 pp., 3 maps. - H.J. de Graaf, Generale missiven van Gouverneur-Generaal en Raden aan Heren XVII der Verenidge Oostindische Compagnie. Deel III: 1655-1674. Uitgegeven door Dr. W. Ph. Coolhaas. ‘s-Gravenhage. Rijks Geschiedkundige Publicatiën. Grote Serie 125. Verkrijkbaar bij Martinus Nijhoff. 1968. - Anthony Reid, G.J. Resink, Indonesia’s history between the myths: Essays in legal history and historical theory. Selected Studies on Indonesia, Vol. 7; The Hague, Van Hoeve, 1968, 457 pp. - R.F. Beerling, S. Takdir Alisjahbana, Values as integrating forces in personality, society and culture. University of Oxford Press, Kuala Lumpur, 1966, 248 bldz.

  13. Golden book

    CERN Document Server

    2004-01-01

    On 19 October, CERN reached the climax of its Jubilee with the official celebration in the presence of very high representatives of the Member and Observer States. Above, one of the high moments of the day: the signing of the golden book by the King of Spain, Juan Carlos, and at his right the Director-General of CERN, Robert Aymar, the President of the Swiss Confederation, Joseph Deiss, and the President of the Republic of France, Jacques Chirac. A complete report of this event will be in the next issue of the Bulletin.

  14. Book Reviews

    Directory of Open Access Journals (Sweden)

    Daniel Eltringham

    2016-05-01

    Full Text Available Book reviews of the following academic titles: 'Late Modernism' and The English Intelligencer: 'On the Poetics of Community' by Alex Latter, London: Bloomsbury Academic, 276 pp., 2015 'The Writing Occurs as Song: A Kelvin Corcoran Reader' by Andy Brown (ed., Bristol: Shearsman, 260 pp., 2014 'Out of Everywhere 2: Linguistically Innovative Poetry by Women in North America & the UK' by Emily Critchley (ed., Hastings: Reality Street, 362 pp., 2015  'Women’s Experimental poetry in Britain 1970–2010: Body, Time, Locale' by David Kennedy and Christine Kennedy, Liverpool: Liverpool University Press, 192 pp., 2013

  15. Book Review

    Science.gov (United States)

    Kragh, Helge

    2015-11-01

    Ever since the days of William Blake there has been an underground resistance against the soulless yet triumphant science and its unholy alliance with money, technology and political power. With the nearly undisputed hegemony that science and technological innovation has attained in the post-World War II era, this kind of resistance has resulted in numerous books and articles that in different ways warn against the dark sides of science and the socio-economic system that nourishes a science in degeneration. Classical examples include Herbert Marcuse's One-Dimensional Man (1964), Jacques Ellul's The Technological Society (1965), Theodore Roszak's The Making of a Counter Culture (1968), and Paul Feyerabend's Science in a Free Society (1978). A fair part of the literature written by sociologists and philosophers is not only critical to trends in modern science, but tends to or is overtly anti-science. The book under review belongs in some respects to this heterogeneous literary tradition, but Twilight of the Scientific Age is primarily directed against the institutional system of science and its associated ideology and not against science itself. Indeed, the author is himself a practicing scientist, an astrophysicist, and he emphasizes several times that he firmly believes in science, even that he loves it. He is not a "stupid cultural relativist," he asserts (p. 11), but a critical freethinker independent of dogmatic beliefs.

  16. Book Review:

    Science.gov (United States)

    Poisson, E.

    2006-09-01

    The motion of a charged particle interacting with its own electromagnetic field is an area of research that has a long history; this problem has never ceased to fascinate its investigators. On the one hand the theory ought to be straightforward to formulate: one has Maxwell's equations that tell the field how to behave (given the motion of the particle), and one has the Lorentz-force law that tells the particle how to move (given the field). On the other hand the theory is fundamentally ambiguous because of the field singularities that necessarily come with a point particle. While each separate sub-problem can easily be solved, to couple the field to the particle in a self-consistent treatment turns out to be tricky. I believe it is this dilemma (the theory is straightforward but tricky) that has been the main source of the endless fascination. For readers of Classical and Quantum Gravity, the fascination does not end there. For them it is also rooted in the fact that the electromagnetic self-force problem is deeply analogous to the gravitational self-force problem, which is of direct relevance to future gravitational wave observations. The motion of point particles in curved spacetime has been the topic of a recent Topical Review [1], and it was the focus of a recent Special Issue [2]. It is surprising to me that radiation reaction is a subject that continues to be poorly covered in the standard textbooks, including Jackson's bible [3]. Exceptions are Rohrlich's excellent text [4], which makes a very useful introduction to radiation reaction, and the Landau and Lifshitz classic [5], which contains what is probably the most perfect summary of the foundational ideas (presented in characteristic terseness). It is therefore with some trepidation that I received Herbert Spohn's book, which covers both the classical and quantum theories of a charged particle coupled to its own field (the presentation is limited to flat spacetime). Is this the text that graduate students

  17. Book Review:

    Science.gov (United States)

    Borcherds, P.

    2005-03-01

    This book achieves what its subtitle indicates. The author skilfully weaves together the story of Bragg's life and of the scientific developments with which he was most closely involved. The author has a good understanding of Bragg's scientific work which he explains in considerable detail, with a number of diagrams reproduced from Bragg's papers, and manages to convey the excitement generated by Bragg's discoveries. The salient points of Bragg's life are well known. He was born and brought up in Australia and is still the youngest ever winner of a Nobel prize (though Josephson did his seminal work at a comparable age, it took many years for him to get his Prize). From 1914 to 1918 Bragg was involved with acoustic methods of detecting enemy guns. From 1919 to 1938 he was Professor of Physics in Manchester, and for about a year he was Director of the National Physical Laboratory. He then went to Cambridge as Cavendish Professor until 1953, when he moved to the Royal Institution (where his father had been). While an undergraduate at Cambridge 'Bragg's most influential teacher was...C T R Wilson [Nobel Laureate, 1927]...[whose] lectures "were the best, and delivery the worst, of any lectures to which I have ever been. He mumbled facing the board, he was very hesitant in his delivery, and yet the way he presented the subject was quite brilliant'' '. One wonders how long Wilson's inspirational teaching would survive today, with continual inspections and the requirement to satisfy the demands of the jobsworths. Bragg's comments on this would make interesting reading! Bragg was a very successful public lecturer on science. He made use of vivid analogies, many of which are quoted by Hunter. Since this book is published by Oxford University Press, I hope that some of them may appear in future editions of The Oxford Dictionary of Quotations. (Bragg is included in Mackay's A Dictionary of Scientific Quotations (Bristol: Institute of Physics Publishing)). There are too many

  18. 1987 Books for Young Adults Poll.

    Science.gov (United States)

    Conner, John; Tessmer, Kathleen M.

    1988-01-01

    Presents a list of the 25 most popular reading choices of Iowa high school students. Provides brief summaries and publication information on books in the following categories: autobiography and personal narrative; contemporary realism; historical fiction and nonfiction; humor and satire; sports; and mystery, adventure, and the supernatural. (MM)

  19. Wildlife of New Mexico: A Coloring Book.

    Science.gov (United States)

    MacCarter, Don L.; Oldham, Pat

    This coloring book showing 31 of New Mexico's wild animals was prepared in conjunction with Project WILD, an environmental and conservation education program for elementary and secondary school students. Each page contains a large line drawing of a wild animal, a brief description of its habitat and behavior, and a range map that indicates the…

  20. Kids Count in Delaware: Fact Book, 1995.

    Science.gov (United States)

    Delaware Univ., Newark. Kids Count in Delaware.

    This Kids Count fact book examines statewide trends in the well-being of Delaware's children. The statistical portrait is based on key indicators in four areas: single-parent families, births to teenage mothers, juvenile crime and violence, and education. Following brief sections on the state's demographics and economic status, the fact book…

  1. Book Review:

    Science.gov (United States)

    Webb, Steve

    2008-11-01

    The Polish physicist Józio (Joseph, Josh, Jo) Rotblat was catapulted into the public eye when he (and the 'Pugwash Conferences' organization) received the 1995 Nobel Peace Prize. His life prior to that had been most distinguished but conducted well out of the public eye. Born and raised as a Jewish physicist in pre-World War II Poland, and thus potentially educationally disadvantaged, he battled away for education and scientific achievement. He came to Liverpool University just before the outbreak of World War II, worked in James Chadwick's laboratory on the early beginnings of neutron fission physics, moved to Los Alamos to take part in the US-UK collaborative Manhattan Project to build a nuclear bomb and was motivated by a desire to rid Poland of Nazi 'racial cleansing'. On realizing the US-UK goal was somewhat wider, he resigned this work and dedicated his life to the peaceful uses of radiation and the campaigns to rid the world of the potential world-eliminating possibility of nuclear war. For this purpose he interacted with Albert Einstein and Bertrand Russell, and in July 1957 founded the 'Pugwash Conferences', named for a small fishing village in Nova Scotia, Canada where the first was held. Along the way his personal life was no less dramatic. Cruel events conspired, and his wife Tola remained in Poland and was killed in the Nazi extermination camp at Majdanek. He grieved for his beloved Poland and those left behind or unaccounted for. He was suspected by some Americans of being a spy and had his personal papers and family artefacts impounded. After the war he was Professor of Medical Physics at St Bartholomew's Hospital, London for 30 years up to retirement. After John Roberts, he was the second editor of this journal Physics in Medicine and Biology from 1961-72 (see e.g. Bob Burns' paper in our 50th birthday issue, 2006. Kit Hill's little book which chronicles the life and times of Rotblat weaves together the key events in his personal and professional

  2. Book Review:

    Science.gov (United States)

    Dray, T.

    2006-06-01

    Null hypersurfaces are a mathematical consequence of the Lorentzian signature of general relativity; singularities in mathematical models usually indicate where the interesting physics takes place. This book discusses what happens when you combine these ideas. Right from the preface, this is a no-nonsense book. There are two principal approaches to singular shells, one distributional and the other 'cut and paste'; both are treated in detail. A working knowledge of GR is assumed, including familiarity with null tetrads, differential forms, and 3 + 1 decompositions. Despite my own reasonably extensive, closely related knowledge, there was material unfamiliar to me already in chapter 3, although I was reunited with some old friends in later chapters. The exposition is crisp, with a minimum of transition from chapter to chapter. In fact, my main criticism is that there is no clear statement of the organization of the book, nor is there an index. Everything is here, and the story is compelling if you know what to look for, although it is less easy to follow the story if you are not already familiar with it. But this is really a book for experts, and the authors certainly qualify, having played a significant role in developing and extending the results they describe. It is also entirely appropriate that the book is dedicated to Werner Israel, who pioneered the thin-shell approach to (non-null) singular surfaces and later championed the use of similar methods for analysing null shells. After an introductory chapter on impulsive signals, the authors show how the Bianchi identities can be used to classify spacetimes with singular null hypersurfaces. This approach, due to the authors, generalizes the framework originally proposed by Penrose [1]. While astrophysical applications are discussed only briefly, the authors point out that detailed physical characteristics of signals from isolated sources can be determined in this manner. In particular, they describe the behaviour

  3. Libros de Ciencias en Espanol (Science Trade Books in Spanish).

    Science.gov (United States)

    Schon, Isabel

    1999-01-01

    Presents a list of recently published science books in Spanish. Each entry in the annotated bibliography contains publication information, suggested grade level(s), and a brief description of the publication. Books are listed under the categories of Biology, Physical Science, General Science, and For the Very Young. Also includes references and…

  4. Libros de Ciencias en Espanol (Science Trade Books in Spanish).

    Science.gov (United States)

    Schon, Isabel

    1999-01-01

    Presents a list of recently published science books in Spanish. Each entry in the annotated bibliography contains publication information, suggested grade level(s), and a brief description of the publication. Books are listed under the categories of Biology, Physical Science, General Science, and For the Very Young. Also includes references and…

  5. The Writing Book, by Inky Penguin [and] Teacher's Manual.

    Science.gov (United States)

    Padgett, Ron

    Intended for elementary level students, this book presents 12 writing ideas and several suggestions on how students can make a book using their writing. Each writing idea is presented with a brief description (addressed to the student), several examples of student writing, and a blank page on which to write. Writing ideas include freewriting,…

  6. Book Review:

    Science.gov (United States)

    Unruh, W. G.

    2006-02-01

    Quantum mechanics is one of the most successful theoretical structures in all of science. Developed between 1925-26 to explain the optical spectrum of atoms, the theory over the succeeding 80 years has been extended, first to quantum field theories, gauge field theories, and now even string theory. It is used every day by thousands of physicists to calculate physical phenomena to exquisite precision, with no ambiguity in the results. To claim that this is a theory which is not understood by those physicists is absurd. And yet, as eminent a physicist as Richard Feynman, who did as much as anyone else to extend quantum theory to field theories and was a master at producing those exquisite calculations, could say that anyone who claimed they understood quantum theory clearly did not understand quantum theory. One hundred years ago Einstein postulated one of the most unsettling features of the theory, the wave-particle duality, with his particulate explanation for light of the photoelectric effect, and an explanation which was in direct conflict with Maxwell's brilliant development of a wave, or field, theory of light. Einstein believed that the particulate nature would ultimately be explainable by some sort of non-linear theory of electromagnetism, and was outraged by the acceptance of the community of the probabilistic quantum theory. His programme was of course dealt a (near?) fatal blow by Bell's discovery that the three desiderata - a theory which agrees with experiment, a theory which is local in its effects, and a theory in which nature, at its heart, is not probabilistic - are incompatible. That discomfort felt by Einstein and by Feynman is felt by numerous other people as well. This discomfort is heightened by the fact that the theory of gravity, another of Einstein's great achievements, has resisted all efforts at reconciliation with quantum mechanics. This book explores that discomfort, and tries to pin down what the locus of that discomfort is. For many

  7. Book Reviews

    Directory of Open Access Journals (Sweden)

    J. van Goor

    1997-07-01

    Full Text Available - Peter Boomgaard, Christine Dobbin, Asian entrepreneurial minorities; Conjoint communities in the making of the world economy, 1570-1940. Richmond: Curzon Press, 1996, xiii + 246 pp. [Nordic Institute of Asian Studies Monograph Series 71.] - Ian Brown, Fukuda Shozo, With sweat and abacus; Economic roles of Southeast Asian Chinese on the eve of World War II, edited by George Hicks. Singapore: Select Books, 1995, xii + 246 pp. - Ian Brown, George Hicks, Chinese organisations in Southeast Asia in the 1930s. Singapore: Select Books, 1996, xv + 168 pp. - Matthew I. Cohen, Laurie J. Sears, Shadows of empire; Colonial discourse and Javanese tales. Durham/London: Duke University Press, 1996, xxi + 349 pp. - J. van Goor, Anthony Reid, Southeast Asia in the age of commerce 1450-1680. Vol. II: Expansion and crisis. New Haven/London: Yale University Press, 1993, xv + 390 pp. - J. van Goor, Anthony Reid, Southeast Asia in the age of commerce 1450-1680. Vol. I: The lands below the winds. New Haven/London: Yale University Press, 1988, xvi + 275 pp. - David Henley, Saya S. Shiraishi, Young heroes; The Indnesian family in politics. Ithaca/New York: Southeast Asia Program, Cornell University, Southeast Asia Program Publications, 1997, 183 pp. [Studies on Southeast Asia 22.] - Gerrit Knaap, P. Jobse, Bronnen betreffende de Midden-Molukken 1900-1942. Den Haag: Instituut voor Nederlandse Geschiedenis, 1997. 4 volumes. Rijks Geschiedkundige Publicatiën, Kleine Serie, 81, 82, 83, 84. Volume 1 bewerkt door P. Jobse, 2 en 3 door Ch.F. van Fraassen, 4 door Ch.F van Fraassen en P. Jobse. xii + 578, xii + 578, xii + 711, x + 655, xi + 261 pp., Ch. F. van Fraassen (eds. - Indro Nugroho-Heins, Clara Brakel-Papenhuyzen, Classical Javanese dance; The Surakarta tradition and its terminology. Leiden: KITLV Press, 1995, xi + 252 pp. [Verhandelingen 155.] - László Sluimers, Shigeru Sato, War, nationalism and peasants; Java under the Japanese occupation, 1942-1945. Armonk, New

  8. Best Books of 1977

    Science.gov (United States)

    Gerhardt, Lillian N.; And Others

    1977-01-01

    School Library Journal book review editors have selected and annotated their choices for the best children's and young adults' books from those books that were submitted for review during 1977 by general book trade book publishers. Included in the annotations are: author, title, publisher, price, and recommended reading and interest levels. (JPF)

  9. The Economics of Books

    NARCIS (Netherlands)

    Canoy, M.F.M.; van Ours, J.C.; van der Ploeg, F.

    2005-01-01

    The tensions between books and book markets as expressions of culture and books as products in profit-making businesses are analysed and insights from the theory of industrial organisation are given.Governments intervene in the market for books through laws concerning prices of books, grants for aut

  10. Size of shell universe in light of Fermi GBM transient associated with GW150914

    Directory of Open Access Journals (Sweden)

    Merab Gogberashvili

    2016-12-01

    Full Text Available The possible burst occurred in location and temporal consistence with gravitational wave event GW150914, as reported by Fermi GBM, offers a new way of constraining models with extra dimensions. Using the time delay in arrival of the gamma ray transient observed by Fermi Gamma-ray Burst Monitor (GMB relative to the gravitational waves event triggered by the LIGO detectors we investigate the size of the spherical brane-universe expanding in multi-dimensional space–time. It is shown that a joint observation of gravitational waves in association with gamma ray burst can provide a very stringent bound on the spatial curvature of the brain.

  11. Molecular architecture of the Goodpasture autoantigen in anti-GBM nephritis.

    Science.gov (United States)

    Pedchenko, Vadim; Bondar, Olga; Fogo, Agnes B; Vanacore, Roberto; Voziyan, Paul; Kitching, A Richard; Wieslander, Jörgen; Kashtan, Clifford; Borza, Dorin-Bogdan; Neilson, Eric G; Wilson, Curtis B; Hudson, Billy G

    2010-07-22

    In Goodpasture's disease, circulating autoantibodies bind to the noncollagenous-1 (NC1) domain of type IV collagen in the glomerular basement membrane (GBM). The specificity and molecular architecture of epitopes of tissue-bound autoantibodies are unknown. Alport's post-transplantation nephritis, which is mediated by alloantibodies against the GBM, occurs after kidney transplantation in some patients with Alport's syndrome. We compared the conformations of the antibody epitopes in Goodpasture's disease and Alport's post-transplantation nephritis with the intention of finding clues to the pathogenesis of anti-GBM glomerulonephritis. We used an enzyme-linked immunosorbent assay to determine the specificity of circulating autoantibodies and kidney-bound antibodies to NC1 domains. Circulating antibodies were analyzed in 57 patients with Goodpasture's disease, and kidney-bound antibodies were analyzed in 14 patients with Goodpasture's disease and 2 patients with Alport's post-transplantation nephritis. The molecular architecture of key epitope regions was deduced with the use of chimeric molecules and a three-dimensional model of the alpha345NC1 hexamer. In patients with Goodpasture's disease, both autoantibodies to the alpha3NC1 monomer and antibodies to the alpha5NC1 monomer (and fewer to the alpha4NC1 monomer) were bound in the kidneys and lungs, indicating roles for the alpha3NC1 and alpha5NC1 monomers as autoantigens. High antibody titers at diagnosis of anti-GBM disease were associated with ultimate loss of renal function. The antibodies bound to distinct epitopes encompassing region E(A) in the alpha5NC1 monomer and regions E(A) and E(B) in the alpha3NC1 monomer, but they did not bind to the native cross-linked alpha345NC1 hexamer. In contrast, in patients with Alport's post-transplantation nephritis, alloantibodies bound to the E(A) region of the alpha5NC1 subunit in the intact hexamer, and binding decreased on dissociation. The development of Goodpasture

  12. Techniques for Targeted Fermi-GBM Follow-Up of Gravitational-Wave Events

    Science.gov (United States)

    Blackburn, L.; Camp, J.; Briggs, M. S.; Connaughton, V.; Jenke, P.; Christensen, N.; Veitch, J.

    2012-01-01

    The Advanced LIGO and Advanced Virgo ground-based gravitational-wave (GW) detectors are projected to come online 2015 2016, reaching a final sensitivity sufficient to observe dozens of binary neutron star mergers per year by 2018. We present a fully-automated, targeted search strategy for prompt gamma-ray counterparts in offline Fermi-GBM data. The multi-detector method makes use of a detailed model response of the instrument, and benefits from time and sky location information derived from the gravitational-wave signal.

  13. NEW BOOKS

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    Qing Dynasty Archives On the Dalai lamasThe Dalai Lama was one of the two leaders of the Gelug (Yellow) Sect of Tibetan Buddhism. It won the honorific title of the Dalai lama in 1653 from Qing Emperor Shunzhi, and the Living Buddha had since been following the reincarnation system under the supervision of the Central Government. His soul boy was not legal until he won the confirmation of the Central Government. Whenever there is the need not to go through the set system, Central Government permission is a must.The Dalai Lama also did his best to seek authorization of the Central Government which would therefore issue him certificate of authority and seal of power.All these were recorded in archives, part of which are contained in the book. Its major chapters contain 154 pieces of archives related with certification of the Dalai Lama and the Panchen Erdeni under the reign of Qing Emperor Shunzhi, the demise of the Dalai Lama and the Panchen Erdeni, efforts made to look for their soul boys, selection of th

  14. Book reviews

    Directory of Open Access Journals (Sweden)

    T. Abdel-Motey., C. Urfels., K. Rodriguez., J. Mardikian., J.A. Drobnicki., V. Diodato.

    2000-10-01

    Full Text Available Title:(1 The Library and Information Professional’s Guide to the Internet. (2 Reinvention of the Public Library for the 21st Century. (3 Public Library Collection Development in the Information Age. (4 Making Sense of Journals in the Life Science: From Specialty Origins to Contemporary Assortment. (5 The Holocaust: Memories, Research, Reference. (6 How to Index Your Local Newspaper Using WordPerfect or Microsoft Word for Windows. (7 Effective Utilization and Management of Emerging Information Technologies. (8 Information Technology and Organizations: Challenges of New Technologies. (9 Facilities Planning for School Media and Technology Centers. (10 Libraries Without Walls 2: The Delivery of Library Services to Distance Users. (11 New International Directions in HIV Prevention for Gay and Bisexual Men. (12 Soaring to Excellence Videos: Tools of Our Trade III: Books, the Internet, and Beyond.Author:(1Reviewed by Teresa Abdel-Motey. (2Review by Claire Urfels. (3Reviewed by Dr. Ketty Rodriguez. (4Reviewed by Jackie Mardikian. (5Reviewed by John A. Drobnicki.(6Reviewed by Dr. Virgil Diodato. (7Reviewed by Dr. Lisa M. Covi. (8Reviewed by Tom Zillner. (9Reviewed by Dr. W. Bernard Lukenbill. (10Reviewed by Dr. Elizabeth Buchanan. (11Reviewed by Aisha White. (12Reviewed by Phyllis Tragash

  15. Book Reviews

    Directory of Open Access Journals (Sweden)

    Hans Antlöv

    1996-04-01

    , vii + 231 pp., Ulricht Mai (eds. - Tineke Hellwig, Brigitte Müller, Op de wipstoel; De niet-gewettigde inheemse vrouw van de blanke Europeaan in Nederlands-Indië (1890-1940; Een literatuuronderzoek naar beeldvorming en werkelijkheid. Amsterdam: Vakgroep Culturele Antropologie/Sociologie der Niets-Westerse Samenlevingen, 1995, xii + 131 pp. - Jan van der Putten, Liaw Yock Fang, Standard Malay made simple. Singapore: Times Books International, 1988. - Jan van der Putten, Liaw Yock Fang, Standard Indonesian made simple, written with the assistance of Nini Tiley-Notodisuryo, Singapore: Times Books International, 1990. - Jan van der Putten, Liaw Yock Fang, Speak standard Malay; A beginner’s guide. Singapore: Times Books International, 1993, xxii + 280 pp. - Jan van der Putten, Liaw Yock Fang, Speak Indonesian; A beginner’s guide, written in collaboration with Munadi Padmadiwiria and Abdullah Hassan. Singapore: Times Books International, 1990. - Alle G. Hoekema, Chr.G.F. de Jong, Geschiedenis van de Nederlandse Zending op Zuid-Sulawesi 1852-1966; Een bronnenpublicatie. Oegstgeest: Raad voor de Zending der Nederlands Hervormde Kerk, 1995, xi + 524 pp. - George Hotze, Ronald G. Gill, De Indische stad op Java en Madura; Een morfologische studie van haar ontwikkeling. Delft: Publikatieburo Bouwkunde, Technische Universiteit Delft, 1995, 350 pp. - H.A.J. Klooster, Holk H. Dengel, Neuere Darstellung der Geschichte Indonesiens in Bahasa Inonesia; Entwicklung und Tendenzen der indonesischen Historiographie. Stuttgart: Steiner, 1994, vii + 269 pp. - Harry A. Poeze, Hans Antlöv, Imperial policy and Southeast Asian nationalism 1930-1957. Richmond: Curzon Press, 1995, xiii + 323 pp., Stein Tonnesson (eds. - P.W. Preston, Michael Hill, The politics of nation building and citizenship in Singapore. London: Routledge, 1995, x + 285 pp., Lian Kwen Fee (eds. - J.W. (Pim Schoorl, Michael Southon, The navel of the perahu; Meaning and values in the maritime trading economy of a Butonese

  16. Book Reviews

    Directory of Open Access Journals (Sweden)

    Christopher Clapham

    2014-07-01

    Full Text Available This publication includes reviews of the following books:The Horn of Africa by Kidane Mengisteab. Cambridge: Polity, 2014. £15.99 (pbk.. Pp. 240+index. ISBN: 9780745651217. Review by Christopher Clapham. Ethiopia: the last two frontiers by John Markakis. Woodbridge: James Currey, 2011. Pp. 399. $34.95 (pbk.. ISBN: 9781847010742. Review by Christopher Clapham.Regime change and succession politics in Africa: five decades of misrule, edited by Maurice Nyamanga Amutabi and Shadrack Wanjala Nasong’o. New York and London: Routledge, 2013. Pp. 237+bibliography+index, £80.00 (hbk. ISBN13: 9780415534086. Review by Tim Kelsall.China’s resource diplomacy in Africa: powering development? by Marcus Power, Giles Mohan and May-Tan Mullins. New York and Basingstoke: Palgrave MacMillan, 2012. Pp. 329 + xix, £63 (hbk.. ISBN: 9780230229129. Review by Pádraig Carmody.Dealing with government in South Sudan: histories of chiefship, community and state by Cherry Leonardi. Suffolk: James Currey (Eastern African Series, 2013. Pp. 224 + notes + bibliography + index. £45.00 (hbk. ISBN: 9781847010674. Review by Jonathan Fisher. 

  17. Book Reviews

    Directory of Open Access Journals (Sweden)

    Alistair Lamb

    1964-10-01

    Full Text Available - B.V.A. Röling, Paul Shepard, Psycholex. Megwa, New York, 1960. 144 blz. - L. Sluimers, J.F. Cady, Southeast Asia: Its historical development. New York etc., McGraw-Hill Book Company, 1964. XVII, 657, IX blz., foto, krtn. - H.J. de Graaf, Nicholas Tarling, Piracy and politics in the Malay world. A study of British imperialism in nineteenth-century Sout-East Asia. F.W. Cheshire, Melbourne, Canberra, Sydney, 1963. 273 pp., frontispiece, endpaper maps. - W. Brand, N.A. Simoniya, Overseas Chinese in Southeast Asia - A Russian study. Data Paper Number 45, Southeast Asia Program, Department of Far Eastern Studies, Cornell University Press, Ithaca, New York, December 1961, 151 blz. - B.H.M. Vlekke, Alistair Lamb, The China-India border, The origins of the disputed boundaries. Published for the Royal Institute of International Affairs by Oxford University Press, London 1964, XVI + 192 pp. - R.S. Karni, Beda Lim, Malaya, a background bibilography. Journal Malayan Branch, RAS, vol. XXXV, pts. 2 & 3, 1962; V. 199 pp. - L. Sluimers, R.K. Goldsen, Factors related to acceptance of innovation in Bang Chan, Thailand; Analysis of a survey conducted by the Cornell Cross-cultural Methodology Project, May 1955. Cornell Thailand Project Interim Report Series no. 3. Data Paper: No. 25 Southeast Asia Program Department of Far Eastern Studies Cornell University. 3de druk, Ithaca, Cornell University Press, 1963. VIII, 72, X blz., M. Rallis (eds.

  18. Book Review:

    Science.gov (United States)

    Wainwright, John

    2007-04-01

    The present volume is an introduction to general relativity and cosmology, at a level suitable for beginning graduate students or advanced undergraduates. The book consists of two main parts, the first entitled `Elements of differential geometry', and the second `The theory of gravitation'. Chapters 2-7, part I, introduce the basic ideas of differential geometry in a general setting, and are based on previously unpublished notes by one of the authors. On the one hand, the treatment is modern in that it uses a `top-down' approach, i.e. starting with general differentiable manifolds, and deferring the introduction of a metric tensor until after the notions of affine connection and curvature have been introduced. On the other hand, the treatment is classical in that it relies heavily, though not exclusively, on index notation. The general material, chapters 1-7, is then followed by four more specialized chapters dealing with matters of specific interest for general relativity. Topics include symmetry groups acting on Riemannian manifolds, with spherically symmetric spacetimes and spatially homogeneous spacetimes as examples, the efficient calculation of curvature, and the Petrov classification of the Weyl curvature tensor using spinors. Part II deals with general relativity and cosmology. The basic assumptions of the theory and its application to spherically symmetric gravitational fields are discussed in two chapters, and there is some historical material and motivation for the basic assumptions at the beginning of the book. The final chapter contains a detailed discussion of the Kerr solution. But the main emphasis in part II is on relativistic cosmology, in particular the analysis of cosmological models more general than the familiar Friedmann-Lemaitre (FL) models. The material on cosmology begins with a discussion of relativistic hydrodynamics and thermodynamics. The kinematical quantities (rate of expansion, shear, etc, of a timelike congruence) are introduced

  19. The InterPlanetary Network Supplement to the Second Fermi GBM Catalog of Cosmic Gamma-Ray Bursts

    Science.gov (United States)

    Hurley, K.; Aptekar, R. L.; Golenetskii, S. V.; Frederiks, D. D.; Svinkin, D. S.; Pal’shin, V. D.; Briggs, M. S.; Meegan, C.; Connaughton, V.; Goldsten, J.; Boynton, W.; Fellows, C.; Harshman, K.; Mitrofanov, I. G.; Golovin, D. V.; Kozyrev, A. S.; Litvak, M. L.; Sanin, A. B.; Rau, A.; von Kienlin, A.; Zhang, X.; Yamaoka, K.; Fukazawa, Y.; Ohno, M.; Tashiro, M.; Terada, Y.; Barthelmy, S.; Cline, T.; Gehrels, N.; Cummings, J.; Krimm, H. A.; Smith, D. M.; Del Monte, E.; Feroci, M.; Marisaldi, M.

    2017-04-01

    InterPlanetary Network (IPN) data are presented for the gamma-ray bursts in the second Fermi Gamma-Ray Burst Monitor (GBM) catalog. Of the 462 bursts in that catalog between 2010 July 12 and 2012 July 11, 428, or 93%, were observed by at least 1 other instrument in the 9-spacecraft IPN. Of the 428, the localizations of 165 could be improved by triangulation. For these bursts, triangulation gives one or more annuli whose half-widths vary between about 2.‧3° and 16°, depending on the peak flux, fluence, time history, arrival direction, and the distance between the spacecraft. We compare the IPN localizations with the GBM 1σ, 2σ, and 3σ error contours and find good agreement between them. The IPN 3σ error boxes have areas between about 8 square arcminutes and 380 square degrees, and are an average of 2500 times smaller than the corresponding GBM 3σ localizations. We identify four bursts in the IPN/GBM sample whose origins were given as “uncertain,” but may in fact be cosmic. This leads to an estimate of over 99% completeness for the GBM catalog.

  20. Targeting the NG2/CSPG4 proteoglycan retards tumour growth and angiogenesis in preclinical models of GBM and melanoma.

    Science.gov (United States)

    Wang, Jian; Svendsen, Agnete; Kmiecik, Justyna; Immervoll, Heike; Skaftnesmo, Kai Ove; Planagumà, Jesús; Reed, Rolf Kåre; Bjerkvig, Rolf; Miletic, Hrvoje; Enger, Per Øyvind; Rygh, Cecilie Brekke; Chekenya, Martha

    2011-01-01

    Aberrant expression of the progenitor marker Neuron-glia 2 (NG2/CSPG4) or melanoma proteoglycan on cancer cells and angiogenic vasculature is associated with an aggressive disease course in several malignancies including glioblastoma multiforme (GBM) and melanoma. Thus, we investigated the mechanism of NG2 mediated malignant progression and its potential as a therapeutic target in clinically relevant GBM and melanoma animal models. Xenografting NG2 overexpressing GBM cell lines resulted in increased growth rate, angiogenesis and vascular permeability compared to control, NG2 negative tumours. The effect of abrogating NG2 function was investigated after intracerebral delivery of lentivirally encoded shRNAs targeting NG2 in patient GBM xenografts as well as in established subcutaneous A375 melanoma tumours. NG2 knockdown reduced melanoma proliferation and increased apoptosis and necrosis. Targeting NG2 in two heterogeneous GBM xenografts significantly reduced tumour growth and oedema levels, angiogenesis and normalised vascular function. Vascular normalisation resulted in increased tumour invasion and decreased apoptosis and necrosis. We conclude that NG2 promotes tumour progression by multiple mechanisms and represents an amenable target for cancer molecular therapy.

  1. Targeting the NG2/CSPG4 proteoglycan retards tumour growth and angiogenesis in preclinical models of GBM and melanoma.

    Directory of Open Access Journals (Sweden)

    Jian Wang

    Full Text Available Aberrant expression of the progenitor marker Neuron-glia 2 (NG2/CSPG4 or melanoma proteoglycan on cancer cells and angiogenic vasculature is associated with an aggressive disease course in several malignancies including glioblastoma multiforme (GBM and melanoma. Thus, we investigated the mechanism of NG2 mediated malignant progression and its potential as a therapeutic target in clinically relevant GBM and melanoma animal models. Xenografting NG2 overexpressing GBM cell lines resulted in increased growth rate, angiogenesis and vascular permeability compared to control, NG2 negative tumours. The effect of abrogating NG2 function was investigated after intracerebral delivery of lentivirally encoded shRNAs targeting NG2 in patient GBM xenografts as well as in established subcutaneous A375 melanoma tumours. NG2 knockdown reduced melanoma proliferation and increased apoptosis and necrosis. Targeting NG2 in two heterogeneous GBM xenografts significantly reduced tumour growth and oedema levels, angiogenesis and normalised vascular function. Vascular normalisation resulted in increased tumour invasion and decreased apoptosis and necrosis. We conclude that NG2 promotes tumour progression by multiple mechanisms and represents an amenable target for cancer molecular therapy.

  2. The effect of silver nanoparticles (AgNPs) on proliferation and apoptosis of in ovo cultured glioblastoma multiforme (GBM) cells

    Science.gov (United States)

    Urbańska, Kaja; Pająk, Beata; Orzechowski, Arkadiusz; Sokołowska, Justyna; Grodzik, Marta; Sawosz, Ewa; Szmidt, Maciej; Sysa, Paweł

    2015-03-01

    Recently, it has been shown that silver nanoparticles (AgNPs) provide a unique approach to the treatment of tumors, especially those of neuroepithelial origin. Thus, the aim of this study was to evaluate the impact of AgNPs on proliferation and activation of the intrinsic apoptotic pathway of glioblastoma multiforme (GBM) cells cultured in an in ovo model. Human GBM cells, line U-87, were placed on chicken embryo chorioallantoic membrane. After 8 days, the tumors were divided into three groups: control (non-treated), treated with colloidal AgNPs (40 μg/ml), and placebo (tumors supplemented with vehicle only). At the end of the experiment, all tumors were isolated. Assessment of cell proliferation and cell apoptosis was estimated by histological, immunohistochemical, and Western blot analyses. The results show that AgNPs can influence GBM growth. AgNPs inhibit proliferation of GBM cells and seem to have proapoptotic properties. Although there were statistically significant differences between control and AgNP groups in the AI and the levels of active caspase 9 and active caspase 3, the level of these proteins in GBM cells treated with AgNPs seems to be on the border between the spontaneous apoptosis and the induced. Our results indicate that the antiproliferative properties of silver nanoparticles overwhelm proapoptotic ones. Further research focused on the cytotoxic effect of AgNPs on tumor and normal cells should be conducted.

  3. BOOK REVIEW: Complete Physics

    Science.gov (United States)

    Carson, Simon

    2000-03-01

    ', begins with an emphasis on the correct use of units in calculations that is very good (although again only really appropriate for more able students) and considers scientific notation and SI units. The use of triangles for rearranging three variable equations is introduced without any discussion of how to do the algebra properly. I found this rather out of place in a book of this level; I should personally hope to see those intending to pursue the subject beyond GCSE capable of rearranging equations without recourse to methods which convey no understanding of the physical relationship. The section on the `History of Key Ideas' has a double page spread on `Forces, Motion and Energy', `Rays, Waves and Particles' and `The Earth and Beyond', followed by a chronology of physics from 400 BC to 1990. These sections are necessarily very brief. The final section, `Experimental Physics', has some useful reminders for students about investigative work and a photocopiable checklist. The book has some very attractive features. Most pages include a boxed list of `essentials' that are useful either in skimming the text to find useful information or in revision. Each double page spread into which the material is arranged includes some fairly straightforward questions to test the basic ideas. Each section ends with a set of examination questions and with a checklist of ideas that can be photocopied for students to tick off what has been covered. The contents pages of the book may also be photocopied for students to check their progress. Given that this is a brand new book, I found the inclusion of a spread on ticker-tape rather old-fashioned: video is a much better way of analysing motion. The language of the text, too, can be rather dry and academic, and the organization reflects a traditional approach to the physics curriculum. The book would be most useful, I think, to able students studying single-subject physics courses at GCSE or to those beginning A-level. At £14.00 a copy, it

  4. Book Reviews

    Directory of Open Access Journals (Sweden)

    Adrianus Koster

    1981-01-01

    Full Text Available - H.J.M. Claessen, David Lewis, From Maui to Cook: The discovery and settlement of the Pacific, Drawings by Walter Stackpool. Sydney: Doubleday, 1977. Bibliography. - P. van Emst, Carl Lumholtz, Among Cannibals. An account of four years travel in Australia and of camp life with the aborigines of Queensland. Firle: Caliban Books. 383 pp. Maps, illustrations and index. Reprinted from the first edition, London: John Murray. - D.C. Geirnaert-Martin, Robert Wessing, Cosmology and social behaviour in a West Javanese settlement, Papers in International Studies, Southeast Asia Series no. 47, Ohio University Center for International Studies, Southeast Asia Program, 1978, Athens, Ohio. - B.G. Grijpstra, William Wood, Cultural-ecological perspectives in Southeast Asia, edited and with an introduction by William Wood, Papers in International Studies, Southeast Asia Studies no. 41, Ohio University Center for International Studies, Southeast Asia Program, 1977, Athens, Ohio. - R. Hagesteijn, M. Jacq-Hergoualc’h, L’armement et l’organisation de l’armée khmère aux XIIe et XIIIe siècles; d’après les bas-reliefs d’Angkor Vat, du Bayon et de Bantay Chmar. Paris: Presses Universitaires de France. - C.K. Jonker-de Putter, John Ingleson, Road to exile; The Indonesian nationalist movement, 1927-1934. ASAA Southeast Asia Publications Series, No. 1. Heinemann Educational Books (Asia Ltd., Singapore, 1979. xii + 254 blz. Bibliographie, index. - P.E. de Josselin de Jong, Roland Werner, Jah-het of Malaysia: art and culture, 1975. Kuala Lumpur: Penerbit Universiti Malaya. xxxv, 626 pp., 39 figs., 2 maps, 746 plates. - P.E. de Josselin de Jong, Roland Werner, Mah-Meri of Malaysia: Art and culture, 1974. Kuala Lumpur: Penerbit Universiti Malaya. xxvi, 485 pp., 13 figs., 3 maps, 460 plates. - Simon Kooijman, Peter Gathercole, The art of the Pacific Islands. National Gallery of Art, Washington, 1979, 365 pp., 386 illustrations + 6 sketch-maps., Adrienne L

  5. Book reviews

    Directory of Open Access Journals (Sweden)

    Redactie KITLV

    2010-09-01

    upland Southeast Asia. (Guido Sprenger Guido Sprenger, Die Männer, die den Geldbaum fällten; Konzepte von Austausch und Gesellschaft bei den Rmeet von Takheung, Laos. (Oliver Tappe Review Essay Two books on East Timor. Carolyn Hughes, Dependent communities; Aid and politics in Cambodia and East Timor. David Mearns (ed., Democratic governance in Timor-Leste; Reconciling the local and the national. (Helene van Klinken Review Essay Two books on Islamic terror Zachary Abuza, Political Islam and violence in Indonesia. Noorhaidi Hasan, Laskar jihad; Islam, militancy, and the quest for identity in post-New Order Indonesia. (Gerry van Klinken Korte Signaleringen Janneke van Dijk, Jaap de Jonge en Nico de Klerk, J.C. Lamster, een vroege filmer in Nederlands-Indië. Griselda Molemans en Armando Ello, Zwarte huid, oranje hart; Afrikaanse KNIL-nazaten in de diaspora. Reisgids Indonesië; Oorlogsplekken 1942-1949. Hilde Janssen, Schaamte en onschuld; Het verdrongen oorlogsverleden van troostmeisjes in Indonesië. Jan Banning, Comfort women/Troostmeisjes. (Harry Poeze

  6. Book Review:

    Science.gov (United States)

    Carlip, S.

    2006-10-01

    The early 1980s, when I first learned theory, were desperate times for graduate students. We searched frantically for coherent introductions, passing tattered copies of review articles around like samizdat, struggling over obscure references to ancient models of strong interactions, and flocking to lectures—not least those by Joe Polchinski—that promised to really explain what was going on. If only this book had been around, it would have saved much grief. Volume I, The Bosonic String, offers a clear and well organized introduction to bosonic string theory. Topics range from the 'classical' (spectra, vertex operators, consistency conditions, etc.) to the 'modern' (D-branes first appear in an exercise at the end of chapter 1, noncommutative geometry shows up in chapter 8). Polchinski does not hesitate to discuss sophisticated matters—path integral measures, BRST symmetries, etc.—but his approach is pedagogical, and his writing is lucid, if sometimes a bit terse. Chapters end with problems that are sometimes difficult but never impossible. A very useful annotated bibliography directs readers to resources for further study, and a nearly 30-page glossary provides short but clear definitions of key terms. There is much here that will appeal to relativists. Polchinski uses the covariant Polyakov path integral approach to quantization from early on; he clearly distinguishes Weyl invariance from conformal invariance; he is appropriately careful about using complex coordinates on topologically nontrivial manifolds; he keeps the string world sheet metric explicit at the start instead of immediately hiding it by a gauge choice. Volume II includes an elegant introduction to anticommuting coordinates and superconformal transformations. A few conventions may cause confusion—%, Polchinski's stress energy tensor, for instance, differs from the standard general relativistic definition by a factor of -2π, and while this is briefly mentioned in the text, it could easily be

  7. Book Review:

    Science.gov (United States)

    Borcherds, P. H.

    2004-09-01

    There is a new tradition in England called Apple Day which is held on some day in October. The actual day varies from place to place. For instance, in 2003, 23 October was Apple Day at Woolsthorpe Manor, the house where Isaac Newton was born and where, during the Plague, he is said to have developed the theory of gravity. (For information on future Apple Days see, for example, http://www.nationaltrust.org.uk/main/thingstodo.) Last year in our garden we picked an apple which weighed one pound, thirteen and a half ounces (1 lb 13 1/2 oz or 29 1/2 oz). The following day we went to an Apple Day event where there were many exotic apples on display, varieties which are not sold in shops. One of the varieties there was called 'Twenty Ounce'. By now you may be wondering what all this has to do with the book being reviewed. We shall return to this later. This entertaining book is ostensibly about units, in particular about Imperial and metric units, but there are numerous informative digressions. The author reminds us that almost every country 'with the exception of the United States, North and South Yemen, Burma and Brunei' has gone metric. He points out that the United States (US) became officially metric in 1893. However, as early as 1866, the US legal definition of the metre was 39.370000 inches. He tells us that after World War II the (US) inch was rounded down (from 25.400051) to 25.4 mm. There is no mention that the Imperial (British) inch was simultaneously rounded up from 25.399956 mm to 25.4 mm. The author frequently digresses, covering such matters as the trisection of angles and Eratosthenes' graphic solution for duplicating the cube. There is an informative discussion on the length of the day: appropriately 25 December, which lasts for 24 h and 30 s, is the longest day. He shows how with cycles and epicycles one can construct an ellipse. Ptolemy did not realize the importance of the focus of the ellipse. The author discusses various topics in the development of

  8. Book Reviews

    Directory of Open Access Journals (Sweden)

    J. Noorduyn

    1982-10-01

    Full Text Available - C. van Dijk, M.C. Ricklefs, A history of modern Indonesia. C. 1300 to the present, London and Basingstoke, The MacMillan Press Ltd., 1981. xii + 335 pp. MacMillan Asian Histories Series. - L.A. Hoedemaker, S.C. Graaf van Randwijck, Handelen en denken in dienst der zending (Oestgeest 1897-1942, 2 delen, Den Haag Boekencentrum, 1981. - G.J. Knaap, Hubert Jacobs SJ, Documenta Malucensia II (1577-1606, annotated by Hubert Jacobs SJ, Monumenta Missionum Societatis Iesu volumen XXXIX, Missiones Orientalis, Rome, Jesuit Historical Institute; 1980, XXXI + 65* + 794 blz. - David S. Moyer, H. Sutherland, The making of a bureaucratic elite; The colonial transformation of the Javanese Priyayi, Asian studies association of Australia, Southeast Asia publication series no. 2, Heinemann educational books (Asia, Singapore, Kuala Lumpur, Hong Kong, 1979, xx + 182 pp. - S.A. Niessen, Garrett Solyom, The world of the Javanese Keris, 1978, East-West Centre, Honolulu, Hawaii., Bronwen Solyom (eds. - S.A. Niessen, Anne Leonard, Patterns of Paradise; The styles and significance of bark cloth around the world, 1980, Field museum of natural history., John Terrell (eds. - S.A. Niessen, Kirk Endicott, Batek Negrito Religion, 1979, Oxford Clarendon Press. - J. Noorduyn, Olivier Carré, L’Islam et l’état dans le monde d’aujourd’hui, Paris, Presses Universitaires de France, 1982. 270 p. - H.A. Poeze, Joop Morriën, Indonesië los van Holland. De CPN en de PKI in hun strijd tegen het Nederlands kolonialisme, Pegasus Amsterdam, 1982, 272 pp.

  9. Book Reviews

    Directory of Open Access Journals (Sweden)

    J.G. Oosten

    1980-10-01

    Full Text Available - M.A. van Bakel, Frederic L. Pryor, The origins of the economy. A comparative study of distribution in primitive and peasant economies. Academic Press, New York 1977. XVIII + 475 blz. - H.J. de Graaf, W. Ph. Coolhaas, Generale missiven van Gouverneurs-Generaal en Raden aan heren XVII der Verenigde Oost-Indische Compagnie. Deel VII. 1713-1725. ‘s-Gravenhage 1979. Rijks geschiedkundige publicatiën. Grote Serie 164. - F.G.P. Jaquet, P. Sutikno, J. Bastin, Nineteenth century prints and illustrated books of Indonesia; with particular reference to the print collection of the Tropenmuseum, Amsterdam; a descriptive bibliography. Utrecht etc., Het Spectrum, 1979. XIV, 386 pp. Ills., B. Brommer (eds. - S. Kooijman, Adrienne L. Kaeppler, “Artificial curiosities” being an exposition of native manufactures collected on the three Pacific voyages of Captain James Cook, R.N. at the Bernice Pauahi Bishop Museum January 18, 1978 - August 31, 1978 on the occasion of the Bicentennial of the European discovery of the Hawaiian islands by Captain Cook - January 18, 1778. Bernice P. Bishop Museum special publication 65, Honolulu, Hawaii, 1978. - J.G. Oosten, Marcel Mauss, Seasonal variations of the Eskimo. A study in social morphology. Marcel Mauss in collaboration with Henri Beuchat. Translated, with a foreword by James J. Fox. Routledge & Kegan Paul, London, Boston and Henley 1979. - Jérôme Rousseau, W.F. Schneeberger, Contributions to the ethnology of central Northeast Borneo (parts of Kalimantan, Sarawak and Sabah. The University of Berne, Institute of Ethnology, Berne 1979. Series: Studia ethnologica Bernensia, no. 2. 143 pages. Maps, figures, plates.

  10. Book Reviews

    Directory of Open Access Journals (Sweden)

    Yu. V. Maretin

    1975-01-01

    Full Text Available - J. Prins, Buiten de grenzen, sociologische opstellen aangeboden aan Prof. Dr. W.F. Wertheim, benevens een “bibliografie van de geschriften van W.F. Wertheim”. Boom, Meppel 1971. 365 blz. - H.C.G. Schoenaker, Ethnologische Zeitschrift Zuerich I, 1972. Festschrift Alfred Steinmann. Verlag Herbert Lang & Cie A.G., Bern. 397 pp. - J.C. Neuteboom, Harald Eidheim, Aspects of the Lappish minority situation. Universitetsforlaget, Oslo 1971. 86 pags. Fig. - H.J.M. Claessen, Paul Ottino, Rangiroa; parenté étendue, résidence et terres dans un atoll ploynésien. Editions Cujas. Paris 1972. 530 p. Bibl., appendices, 37 fig. en kaarten, registers. - David S. Moyer, Adelin Linton, Ralph Linton. Leaders of Modern Anthropological Series, American University Publishers Group. London 1971, pp. 196., C. Wagley (eds. - R.A.M. van Zantwijk, Carlo J.E. Gay, Chalcacingo. Drawings by Frances Pratt. Akademische Druck- und Verlagsanstalt. Graz 1971. 119 blz., geïll., XXIV fotopag. - P. van Emst, Yu. V. Maretin, Countries and peoples of the East. Vol. XIII, Countries and peoples of the Pacific Basin. Book 2. Nauka Publishing House. Central Department of Oriental Literature. Moscow 1972. (Strany i narody vostoka. Pod obscej redakciej D.A. Ol’derogge. Vypusk XIII. Strany i narody bassejna Tichogo Okeana. Kniga 2. - H. van Mierlo, Atlantische Commissie, De school en het buitenlands beleid IX. De internationale politieke vormingstaak van de school. Atlantische Commissie, Den Haag 1970, 56 blz. - Geert A. Banck, Philip Staniford, Pioneers in the tropics. The political organization of Japanese in an immigrant community in Brazil. London School of Economics Monographs on Social Anthropology no. 45. London; The Athlone Press. 1973. xvi + 201 pag.

  11. Book reviews

    Directory of Open Access Journals (Sweden)

    Redactie KITLV

    1992-07-01

    W. Collinwood ,Modern Bahamian society. Parkersburg IA: Caribbean Books, 1989. 278 pp., Steve Dodge (eds -Peter Hulme, Pierrette Frickey, Critical perspectives on Jean Rhys. Washington DC: Three Continents Press, 1990. 235 pp. -Alvina Ruprecht, Lloyd W. Brown, El Dorado and Paradise: Canada and the Caribbean in Austin Clarke's fiction. Parkersburg IA: Caribbean Books, 1989. xv + 207 pp. -Ineke Phaf, Michiel van Kempen, De Surinaamse literatuur 1970-1985: een documentatie. Paramaribo: Uitgeverij de Volksboekwinkel, 1987. 406 pp. -Genevieve Escure, Barbara Lalla ,Language in exile: three hundred years of Jamaican Creole. Tuscaloosa AL: University of Alabama Press, 1990. xvii + 253 pp., Jean D'Costa (eds -Charles V. Carnegie, G. Llewellyn Watson, Jamaican sayings: with notes on folklore, aesthetics, and social control.Tallahassee FL: Florida A & M University Press, 1991. xvi + 292 pp. -Donald R. Hill, Kaiso, calypso music. David Rudder in conversation with John La Rose. London: New Beacon Books, 1990. 33 pp. -Mark Sebba, John Victor Singler, Pidgin and creole tense-mood-aspect systems. Amsterdam and Philadelphia: John Benjamins, 1990. xvi + 240 pp. -Dale Tomich, Pedro San Miguel, El mundo que creó el azúcar: las haciendas en Vega Baja, 1800-873. Río Piedras, Puerto Rico: Ediciones Huracán, 1989. 224 pp. -César J. Ayala, Juan José Baldrich, Sembraron la no siembra: los cosecheros de tabaco puertorriqueños frente a las corporaciones tabacaleras, 1920-1934. Río Piedras, Puerto Rico: Ediciones Huracán, 1988. -Robert Forster, Jean-Michel Deveau, La traite rochelaise. Paris: Kathala, 1990. 334 pp. -Ernst van den Boogaart, Johannes Menne Postma, The Dutch in the Atlantic slave trade, 1600-1815. Cambridge: Cambridge University Press, 1990. xiv + 428 pp. -W.E. Renkema, T. van der Lee, Plantages op Curacao en hun eigenaren (1708-1845: namen en data voornamelijk ontleend aan transportakten. Leiden, the Netherlands: Grafaria, 1989. xii + 87 pp. -Mavis C. Campbell, Wim

  12. Book Reviews

    Directory of Open Access Journals (Sweden)

    Redactie KITLV

    1992-01-01

    Full Text Available -Selwyn R. Cudjoe, John Thieme, The web of tradition: uses of allusion in V.S. Naipaul's fiction, -A. James Arnold, Josaphat B. Kubayanda, The poet's Africa: Africanness in the poetry of Nicolás Guillèn and Aimé Césaire. Westport CT: Greenwood, 1990. xiv + 176 pp. -Peter Mason, Robin F.A. Fabel, Shipwreck and adventures of Monsieur Pierre Viaud, translated by Robin F.A. Fabel. Pensacola: University of West Florida Press, 1990. viii + 141 pp. -Alma H. Young, Robert B. Potter, Urbanization, planning and development in the Caribbean, London: Mansell Publishing, 1989. vi + 327 pp. -Hymie Rubinstein, Raymond T. Smith, Kinship and class in the West Indies: a genealogical study of Jamaica and Guyana, Cambridge: Cambridge University Press, 1988. xiv + 205 pp. -Shepard Krech III, Richard Price, Alabi's world, Baltimore and London: Johns Hopkins University Press, 1990. xx + 445 pp. -Graham Hodges, Sandra T. Barnes, Africa's Ogun: Old world and new, Bloomington & Indianapolis: Indiana University Press, 1989. xi + 274 pp. -Pamela Wright, Philippe I. Bourgois, Ethnicity at work: divided labor on a Central American banana plantation, Baltimore MD: John Hopkins University Press, 1989. xviii + 311 pp. -Idsa E. Alegría-Ortega, Andrés Serbin, El Caribe zona de paz? geopolítica, integración, y seguridad, Caracas: Editorial Nueva Sociedad, 1989. 188 pp. (Paper n.p. [Editor's note. This book is also available in English: Caribbean geopolitics: towards security through peace? Boulder CO: Lynne Rienner, 1990. -Gary R. Mormino, C. Neale Ronning, José Martí and the émigré colony in Key West: leadership and state formation, New York; Praeger, 1990. 175 pp. -Gary R. Mormino, Gerald E. Poyo, 'With all, and for the good of all': the emergence of popular nationalism in the Cuban communities of the United States, 1848-1898, Durham NC: Duke University Press, 1989. xvii + 182 pp. -Fernando Picó, Raul Gomez Treto, The church and socialism in Cuba, translated from

  13. The Economics of Books

    OpenAIRE

    Canoy, M.F.M.; Ours, J. C. van; van der Ploeg, F.

    2005-01-01

    The tensions between books and book markets as expressions of culture and books as products in profit-making businesses are analysed and insights from the theory of industrial organisation are given. Governments intervene in the market for books through laws concerning prices of books, grants for authors and publishers, a lower value-added tax, public libraries and education in order to stimulate the diversity of books on offer, increase the density of retail outlets and to promote reading. A...

  14. Traditional to Digital Books

    Institute of Scientific and Technical Information of China (English)

    JING XIAOLEI

    2010-01-01

    @@ A book fair wouldn't be a book fair without books.And while the number of book fairs in China has increased in recent years,the Guangzhou Book Fair has been helping to redefine the very nature of books by promoting digital works and reading technology.This year,the fair again set up an exclusive digital reading experience exhibition hall to showcase the host province's latest achievements in the field.

  15. 方剂学简史及历代方论十大名著之刍议%On Prescription Brief History and Ten Famous Books of Discourse on Prescriptions in Ancient Dynasties

    Institute of Scientific and Technical Information of China (English)

    朱燕; 李顺保

    2013-01-01

    The history of prescription was illustrated by taking the meridians of "medical prescription","discourse on prescriptions"and"serial prescriptions"as the axes, meanwhile, ten famous books about discourse on prescriptions in ancient dynasties were analyzed;which was well arranged, more clear and detailed than chronicles of prescription holding time as the parallel.%以“医方”“方论”“类方”三条经线为轴,探讨和阐释方剂学发展史,同时对历代医家方论十大名著进行剖析和诠释;较之以时代为纬线的方剂学编年史式阐述更加凸显层次分明、说理清晰及条分缕析之特点。

  16. The Fermi Gamma-ray Burst Monitor (GBM) Terrestrial Gamma-ray Flash (TGF) Catalog

    Science.gov (United States)

    Stanbro, M.; Briggs, M. S.; Roberts, O.; McBreen, S.; Bhat, N.; Fitzpatrick, G.

    2015-12-01

    We present results from the catalog of Terrestrial Gamma-ray Flashes (TGFs) detected with the Gamma-ray Burst Monitor (GBM) on the Fermi Gamma-ray Space Telescope. The first release, in January 2015, provided data on 2700 TGFs. Updates are extending the catalog at a rate of ~800 TGFs per year. The TGF sample is reliable, with cosmic rays rejected using data both from Fermi GBM and from the Large Area Telescope on Fermi. The online catalog include times (UTC and solar), spacecraft geographic positions, durations, count intensities and other Bayesian Block durations. The catalog includes separate tables for bright TGFs detected by the flight software and for Terrestrial Electron Beams (TEBs). In January 2016 additional data will be released online from correlating these TGFs with sferics detected by the World Wide Lightning Location Network (WWLLN). Maps of sferics in the vicinity of each TGF will be provided, as will the locations and times of sferics found to be associated with TGFs.

  17. New Methods for Timing Analysis of Transient Events, Applied to Fermi/GBM Magnetar Bursts

    CERN Document Server

    Huppenkothen, Daniela; Uttley, Phil; van der Horst, Alexander J; van der Klis, Michiel; Kouveliotou, Chryssa; Gogus, Ersin; Granot, Jonathan; Vaughan, Simon; Finger, Mark H

    2013-01-01

    In order to discern the physical nature of many gamma-ray sources in the sky, we must look not only in spectral and spatial dimensions, but also understand their temporal variability. However, timing analysis of sources with a highly transient nature, such as magnetar bursts, is difficult: standard Fourier techniques developed for long-term variability generally observed, for example, from AGN often do not apply. Here, we present newly developed timing methods applicable to transient events of all kinds, and show their successful application to magnetar bursts observed with Fermi/GBM. Magnetars are a prime subject for timing studies, thanks to the detection of quasi-periodicities in magnetar Giant Flares and their potential to help shed light on the structure of neutron stars. Using state-of-the art statistical techniques, we search for quasi-periodicities (QPOs) in a sample of bursts from Soft Gamma Repeater SGR J0501+4516 observed with Fermi/GBM and provide upper limits for potential QPO detections. Additio...

  18. Gravitational wave observations may constrain gamma-ray burst models: the case of GW 150914 - GBM

    CERN Document Server

    Veres, P; Goldstein, A; Mészáros, P; Burns, E; Connaughton, V

    2016-01-01

    The possible short gamma-ray burst (GRB) observed by {\\it Fermi}/GBM in coincidence with the first gravitational wave (GW) detection, offers new ways to test GRB prompt emission models. Gravitational wave observations provide previously unaccessible physical parameters for the black hole central engine such as its horizon radius and rotation parameter. Using a minimum jet launching radius from the Advanced LIGO measurement of GW~150914, we calculate photospheric and internal shock models and find that they are marginally inconsistent with the GBM data, but cannot be definitely ruled out. Dissipative photosphere models, however have no problem explaining the observations. Based on the peak energy and the observed flux, we find that the external shock model gives a natural explanation, suggesting a low interstellar density ($\\sim 10^{-3}$ cm$^{-3}$) and a high Lorentz factor ($\\sim 2000$). We only speculate on the exact nature of the system producing the gamma-rays, and study the parameter space of a generic Bl...

  19. Tumour Relapse Prediction Using Multiparametric MR Data Recorded during Follow-Up of GBM Patients

    Directory of Open Access Journals (Sweden)

    Adrian Ion-Margineanu

    2015-01-01

    Full Text Available Purpose. We have focused on finding a classifier that best discriminates between tumour progression and regression based on multiparametric MR data retrieved from follow-up GBM patients. Materials and Methods. Multiparametric MR data consisting of conventional and advanced MRI (perfusion, diffusion, and spectroscopy were acquired from 29 GBM patients treated with adjuvant therapy after surgery over a period of several months. A 27-feature vector was built for each time point, although not all features could be obtained at all time points due to missing data or quality issues. We tested classifiers using LOPO method on complete and imputed data. We measure the performance by computing BER for each time point and wBER for all time points. Results. If we train random forests, LogitBoost, or RobustBoost on data with complete features, we can differentiate between tumour progression and regression with 100% accuracy, one time point (i.e., about 1 month earlier than the date when doctors had put a label (progressive or responsive according to established radiological criteria. We obtain the same result when training the same classifiers solely on complete perfusion data. Conclusions. Our findings suggest that ensemble classifiers (i.e., random forests and boost classifiers show promising results in predicting tumour progression earlier than established radiological criteria and should be further investigated.

  20. Magnetar Twists: Fermi/Gamma ray Burst Monitor (GBM) detection of SGR 1550-5418

    CERN Document Server

    Kaneko, Y; Kouveliotou, C; Ramirez-Ruiz, E; Granot, J; van der Horst, A J; Watts, A L; Finger, M H; Gehrels, N; Pe'er, A; van der Klis, M; von Kienlin, A; Wachter, S; Wilson-Hodge, C A; Woods, P M

    2009-01-01

    SGR 1550-5418 (previously known as AXP 1E 1547.0-5408) went into three active bursting episodes in 2008 October and in 2009 January and March, emitting hundreds of typical Soft Gamma Repeater (SGR) bursts in soft gamma rays. The second episode was especially intense, and our untriggered burst search on Fermi/GBM data (8-1000 keV) revealed ~450 bursts emitted over 24 hours during the peak of this activity. Using the GBM data, we identified a ~150-s-long enhanced persistent emission during 2009 January 22 that exhibited intriguing timing and spectral properties: (i) clear pulsations up to ~110 keV at the spin period of the neutron star (P ~2.07 s, the fastest of all magnetars), (ii) an additional (to a power-law) blackbody component required for the enhanced emission spectra with kT ~17 keV, (iii) pulsed fraction that is strongly energy dependent and highest in the 50-74 keV energy band. A total isotropic-equivalent energy emitted during this enhanced emission is estimated to be 4.3 x 10^{40} ergs. We conclude ...

  1. $Fermi$ GBM Observations of V404 Cyg During its 2015 Outburst

    CERN Document Server

    Jenke, P A; Homan, Jeroen; Veres, P; Briggs, M S; Burns, E; Connaughton, V; Finger, M H; Hui, M

    2016-01-01

    V404 Cygni was discovered in 1989 by the $Ginga$ X-ray satellite during its only previously observed X-ray outburst and soon after confirmed as a black hole binary. On June 15, 2015, the Gamma Ray Burst Monitor (GBM) triggered on a new outburst of V404 Cygni. We present 13 days of GBM observations of this latest outburst including Earth occultation flux measurements, spectral and temporal analysis. The Earth occultation fluxes reached 30 Crab with detected emission to 100 keV and determined, via hardness ratios, that the source was in a hard state. At high luminosity, spectral analysis between 8 and 300 keV showed that the electron temperature decreased with increasing luminosity. This is expected if the protons and electrons are in thermal equilibrium during an outburst with the electrons cooled by the Compton scattering of softer seed photons from the disk. However, the implied seed photon temperatures are unusually high, suggesting a contribution from another source, such as the jet. No evidence of state t...

  2. A Brief Illustrated Guide to Understanding Islam. Second Edition.

    Science.gov (United States)

    Ibrahim, I. A.

    This book is a brief guide to understanding Islam, intended to help individuals better understand Islamic culture, Muslims, and the Holy Quran. It consists of the following three chapters: (1) Some Evidence for the Truth of Islam; (2) Some Benefits of Islam; and (3) General Information on Islam. The book is extensively illustrated with photographs…

  3. Notch- and vitamin D signaling in 1,25(OH)2D3-resistant glioblastoma multiforme (GBM) cell lines.

    Science.gov (United States)

    Reichrath, Sandra; Müller, Cornelia S L; Gleissner, Beate; Pfreundschuh, Michael; Vogt, Thomas; Reichrath, Jörg

    2010-07-01

    Recently, an important role of Notch activation for Ras-induced transformation of glial cells and for glioma growth and survival has been demonstrated. It was concluded that activation of Notch-signaling may represent a new target for glioblastoma multiforme (GBM) therapy. We now analyzed five GBM cell lines (Tx3095, Tx3868, U87, U118, U373) for key components of Notch-signaling pathways (Notch-1, Notch-2, Notch-3, Notch-4, Delta-like 1, Delta-like 3, Delta-like 4, Jagged-1, Jagged-2) using conventional RT-PCR. We found that some components (Notch-1, Notch-2, Notch-4, Jagged-1) were consistently expressed in all cell lines analyzed while, in contrast, other key components of Notch-signaling were differentially expressed. Notch-3 was expressed in three out of five cell lines (in U87, U118 and U373), but was missing in Tx3095 and Tx3868 cells. Jagged-2 was expressed in U87, U373 and Tx3868, but not in U118 or Tx3095 cells. Delta-like 1 and Delta-like 3 were not detected in Tx3905 cells, but in all other cell lines. RNA for Delta-like 4 was only found in U373 and Tx3868 GBM cell lines. Treating GBM cell lines with 1,25(OH)2D3 (10(-6), 10(-8), and 10(-10) M), the biologically active form of vitamin D, did not result in significant dose- or time-dependent antiproliferative effects, indicating that GBM cell lines are resistant against the antiproliferative activity of 1,25(OH)2D3. In vitro treatment of GBM cells with 1,25(OH)2D3 did not result in a modulation of the expression of key components of the Notch-signaling pathway. Treatment with HDAC-inhibitor TSA or DNA-methyltransferase inhibitor 5-aza exerted dose- and time-dependent antiproliferative effects on GBM cell lines. We asked the question whether the resistance against 1,25(OH)2D3 could be restored by co-treatment with TSA or 5-aza. However, combination therapy with 1,25(OH)2D3 and TSA or 5-aza did not result in enhanced antiproliferative effects as compared to treatment with TSA or 5-aza alone. In contrast

  4. Technology, Media and the Book: Blurring Genres and Expanding the Reach of Children's Literature.

    Science.gov (United States)

    Rogers, Theresa; Tyson, Cynthia; Enciso, Patricia; Marshall, Elizabeth; Jenkins, Christine; Brown, Jacqueline; Core, Elizabeth; Cordova, Carmen; Youngsteadt-Parish, Denise; Robinson, Dwan

    2000-01-01

    Presents a short dialogue on issues of representing children's literature for a wider audience, regarding "Harry Potter and the Sorcerer's Stone." Discusses a featured book and offers brief descriptions of 5 picture books and informational texts, and 6 autobiographies, discussing them in tandem with 15 landmark children's books. (SR)

  5. Preliminary study of technical terminology for the retrieval of scientific book metadata records

    DEFF Research Database (Denmark)

    Larsen, Birger; Lioma, Christina; Frommholz, Ingo

    2012-01-01

    Books only represented by brief metadata (book records) are particularly hard to retrieve. One way of improving their retrieval is by extracting retrieval enhancing features from them. This work focusses on scientific (physics) book records. We ask if their technical terminology can be used...

  6. Booklists for the Teaching of Mathematics in Schools: Full List of Recommended Books (Ref: FULL).

    Science.gov (United States)

    Mathematical Association, Leicester (England).

    Presented is a listing of all books recommended by the Mathematical Association of the United Kingdom. The following information on each book is provided: author; title; publisher; cost to the nearest pound; categories of use; and a code that indicates if the book is out of print, reprinted, and/or highly recommended. Brief annotations are…

  7. World Wide Book: A Digitalização e o Livro

    Directory of Open Access Journals (Sweden)

    Sandra Bettencourt

    2014-11-01

    Full Text Available Brief presentation of seven archives containing digitized representations of bibliographic collections or reflections on digital and post-digital forms of the book: Codices Electronici Sangallenses, Digital Scriptorium, Artists' Books Online, Tipo.PT, University of Iowa Libraries Bookbinding Models, Post-Digital Publishing Archive and The Institute for the Future of the Book.

  8. Technology, Media and the Book: Blurring Genres and Expanding the Reach of Children's Literature.

    Science.gov (United States)

    Rogers, Theresa; Tyson, Cynthia; Enciso, Patricia; Marshall, Elizabeth; Jenkins, Christine; Brown, Jacqueline; Core, Elizabeth; Cordova, Carmen; Youngsteadt-Parish, Denise; Robinson, Dwan

    2000-01-01

    Presents a short dialogue on issues of representing children's literature for a wider audience, regarding "Harry Potter and the Sorcerer's Stone." Discusses a featured book and offers brief descriptions of 5 picture books and informational texts, and 6 autobiographies, discussing them in tandem with 15 landmark children's books. (SR)

  9. Book Reviews

    Directory of Open Access Journals (Sweden)

    Ger P. Reesink

    1995-07-01

    Full Text Available - Rogier Busser, Peter Post, Japanse bedrijvigheid in Indonesië, 1868-1942; Structurele elementen van Japan’s vooroorlogse economische expansie in Zuidoost Azië. Proefschrift Vrije Universiteit, Amsterdam, 1991, xviii + 374 pp. - H.J.M. Claessen, Arne Aleksej Perminow, The long way home; Dilemmas of everyday life in a Tongan village. Oslo: Scandinavian University Press, 1993, 166 pp. - Aone van Engelenhoven, René van den Berg, Studies in Sulawesi linguistics III. Jakarta: Badan Penyelenggara Seri Nusa, Universitas Katolik Indonesia Atma Jaya, 1994, xii + 116 pp. [NUSA, Linguistic Studies of Indonesian and Other Languages in Indonesia 36.] - Will Derks, Wolfgang Marschall, Texts from the Islands; Oral and written traditions of Indonesia and the Malay world, (Procedings of the 7th European Colloquium on Indonesia and Malay Studies, Berne, June 1989 1994, iii + 411 pp. [Ethnologica Bernensia 4]. - Michael Kaden, Krishna Sen, Indonesian Cinema; Framing the New Order, London: Zed Books, 1994, x + 188 pp. - Nico Kaptein, Mona Abaza, Indonesian Students in Cairo; Islamic education perceptions and exchanges, Paris: Association Archipel, 1994, 198 pp. [Cahier d’Archipel 23.] - P. Keppy, Chris Manning, Indonesia assessment 1993; Labour: Sharing in the benefits of growth? Canberra: Australian National University, 1993, xxi + 326 pp., Joan Hardjono (eds. - Anke Niehof, Jan-Paul Dirkse, Development and social welfare; Indonesia’s experiences under the New Order, Leiden: KITLV Press, 1993, xi + 295 pp., Frans Hüsken, Mario Rutten (eds. - Hetty Nooy-Palm, Michale C. Howard, Textiles of Southeast Asia; An annotated and illustrated bibliography. Bangkok: White Lotus, 1994, 212 pp. + 64 pp. pf photographs in colour. - Harry A. Poeze, Hans van Miert, Een koel hoofd en een warm hart; Nationalisme, Javanisme en jeugdbeweging in Nederlands-Indië, 1918-1930. Amsterdam: De Bataafsche Leeuw, 1995, 424 pp. - Ger P. Reesink, Jürg Wassmann, Historical atlas of

  10. Book Reviews

    Directory of Open Access Journals (Sweden)

    F.L. van Holthoon

    1970-01-01

    Full Text Available - Yvan Simonis, Bertel Nathhorst, Formal or structural studies of traditional tales. The usefulness of some methodological proposals advanced by Vladimir Propp, Alan Dundes, Claude Levi-Strauss and Edmund Leach. Acta Universitatis Stockholmiensis, Stockhlom Studies in Comparative Religion, 9 - Stockholm 1969. 80 p. bibliogr., index. - A.J.F. Köbben, G.P. Murdock, Ethnographic atlas. University of Pittsburgh Press, 1967. 128 pp. - J. Blauw, Banton Michael, Anthropological approaches to the study of religion. Tavistock Publications, London, 1966. XZII en 176p. - C. Baks, J.F. Boissevain, Netwerken en quasi-groepen; enkele beschouwingen over de plaats van de Niet-Groepen in de Sociale Wettenschappen. Oratie. Van Gorcum & Comp., Assen 1968. 44 pp. - C.J. Lammers, Tom Burns, Industrial man. Penguin Modern Sociology Readings. Harmondsworth, Middlesex: Penguin Books Ltd. 1969. 414 pp. - P. van Daalen, M.M. Albinski, Maatschappelijke behoefte aan sociologen. Rede Katholieke Universiteit te Nijmegen. Van Gorcum, Assen 1969. 37 blz. - W. Brand, Louise B. Young, Population in perspective. Oxford University Press, New York/London/Toronto, 1968. 460 blz. - J.H.B. den Ouden, C. Baks, Afschaffing van Pacht. Een onderzoek naar de sociale gevolgen van de afschaffing van pacht in twee dorpen van Zuid-Gujerat, India. Publikatie no. 13. Afdeling Zuid- en Zuidoost-Azië. Antropologisch-Sociologisch Centrum. Universiteit van Amsterdam. 1969. 228 pp. - Mohan K. Gautam, William H. Newell, A study of Gaddi scheduled tribe - and affiliated castes. Census of India 1961. Vol. XX, Part V-B. Himachal Pradesh. Report on scheduled castes and scheduled tribes. Government of India Press, Simla. 1967. I-IV plus 104 pp. with 14 black and white illustrations, appendices and bibliography. - P.J. van Winter, Monica Wilson, The Oxford history of South Africa. Vol. I, South Africa to 1870. Clarendon Press, Oxford 1969. XXXIII, 502 p., Leonard Thompson (eds. - Jan Knappert, Hasani bin

  11. Briefing Executives

    Science.gov (United States)

    2015-09-01

    in order to move forward. You have to report some bad news. Or maybe it is just an information brief to someone with a reputation for asking hard...face value . He or she will undoubtedly have many questions for you to answer and clarify, and, in the end, the executive may decide on a different...misunderstanding, and we were able to move on. Getting up the nerve to push back wasn’t easy—Meyer had a reputation for gruffness and great technical

  12. Book Reviews

    Directory of Open Access Journals (Sweden)

    Redactie KITLV

    2004-10-01

    : KITLV Press, 2002, viii + 246 pp. [Proceedings 5.], Nico Kaptein (eds -Anton Ploeg, William C. Clarke, Remembering Papua New Guinea; An eccentric ethnography. Canberra: Pandanus Books, Research School of Pacific and Asian Studies, Australian National University, 2003, 178 pp. -Nathan Porath, Gerco Kroes, Same hair, different hearts; Semai identity in a Malay context; An analysis of ideas and practices concerning health and illness. Leiden: Research School of Asian, African and Amerindian Studies (CNWS, Universiteit Leiden, 2002, 188 pp. -Guido Sprenger, Grant Evans, Laos; Culture and society. Chiang Mai: Silkworm Books, 1999, xi + 313 pp. -Gerard Termorshuizen, Dik van der Meulen, Multatuli; Leven en werk van Eduard Douwes Dekker. Nijmegen: SUN, 2002, 912 pp. -Paige West, Karl Benediktsson, Harvesting development; The construction of fresh food markets in Papua New Guinea. Copenhagen: Nordic Institute of Asian Studies/Ann Arbor: University of Michigan Press, 2002, xii + 308 pp. -Edwin Wieringa, Amirul Hadi, Islam and state in Sumatra; A study of seventeenth-century Aceh. Leiden: Brill, 2004, xiii + 273 pp. [Islamic History and Civilization, 48.] -Robin Wilson, Pamela J. Stewart ,Remaking the world; Myth, mining and ritual change among the Duna of Papua New Guinea. Washington: Smithsonian Institution Press, 2002, xvi + 219 pp. [Smithsonian Series in Ethnographic Enquiry.], Andrew Strathern (eds

  13. Identification of a novel set of genes reflecting different in vivo invasive patterns of human GBM cells

    Directory of Open Access Journals (Sweden)

    Monticone Massimiliano

    2012-08-01

    Full Text Available Abstract Background Most patients affected by Glioblastoma multiforme (GBM, grade IV glioma experience a recurrence of the disease because of the spreading of tumor cells beyond surgical boundaries. Unveiling mechanisms causing this process is a logic goal to impair the killing capacity of GBM cells by molecular targeting. We noticed that our long-term GBM cultures, established from different patients, may display two categories/types of growth behavior in an orthotopic xenograft model: expansion of the tumor mass and formation of tumor branches/nodules (nodular like, NL-type or highly diffuse single tumor cell infiltration (HD-type. Methods We determined by DNA microarrays the gene expression profiles of three NL-type and three HD-type long-term GBM cultures. Subsequently, individual genes with different expression levels between the two groups were identified using Significance Analysis of Microarrays (SAM. Real time RT-PCR, immunofluorescence and immunoblot analyses, were performed for a selected subgroup of regulated gene products to confirm the results obtained by the expression analysis. Results Here, we report the identification of a set of 34 differentially expressed genes in the two types of GBM cultures. Twenty-three of these genes encode for proteins localized to the plasma membrane and 9 of these for proteins are involved in the process of cell adhesion. Conclusions This study suggests the participation in the diffuse infiltrative/invasive process of GBM cells within the CNS of a novel set of genes coding for membrane-associated proteins, which should be thus susceptible to an inhibition strategy by specific targeting. Massimiliano Monticone and Antonio Daga contributed equally to this work

  14. Using Book Data Providers to Improve Services to Patrons

    Directory of Open Access Journals (Sweden)

    Mike Beccaria

    2009-03-01

    Full Text Available At Paul Smith's College, I recently implemented a "New Books" display using open APIs and an image scroller. In this article I'll give a brief overview of Google Book Search, OpenLibrary and Worldcat, explain how I created this New Books Widget using book cover data, and provide readers with some practical and simple code to show how to collect this data. This article will be of interest to anyone who wants to read about a brief overview of current state of free book data service providers. Additionally, beginner programmers will likely find the examples at the end of the article helpful when getting started with projects of their own.

  15. Book Review

    Science.gov (United States)

    1999-07-01

    developments. The range of scale of the refrigeration described is extreme, ranging from a 10 mW sorption cooler at 80 K for a detector application, to the 20 kW of cooling required at 1.8 K for the Large Hadron Collider. The following section contains a variety of mainly high-current applications of superconductivity where low-Tc and high-Tc coil and cable designs co-exist side by side in apparent harmony even though the scale and sophistication of the former still exceed the latter by at least an order of magnitude in general. In the final section thermal properties and control techniques for cryogenic systems and large magnet or detector facilities jockey for attention with applications of extremely sensitive thermometry. It is traditional to regard frequency as the most precisely determined physical quantity but this notion begins to be challenged when a magnetic susceptibility thermometer is reported which allows 10-12 K sensitivity at an operating temperature of 2 K. I have one criticism of this volume, which suffers somewhat from a problem which is quite widespread in conference proceedings. Unfortunately, not all of the plenary speakers have supplied full manuscript texts of their talks. Thus it is rather frustrating to be presented in the contents list with titles as tantalizing as `Liquid hydrogen---technology for vehicles' or `High-temperature superconductors in power engineering', to find that a brief abstract only serves to emphasize what delights one is missing, since the full text has not been included. But overall this volume reflects the huge range of capabilities and applications of cryogenic engineering and contains a great deal of interest to the researcher or user of superconductors. John Gallop National Physics Laboratory, UK

  16. Book Reviews

    Directory of Open Access Journals (Sweden)

    Brian Swann

    1983-10-01

    Full Text Available - G.J. Abbink, J.M. Schoffeleers, Missie en Ontwikkeling in Oost-Afrika. Een ontmoeting van culturen, Nijmegen-Baarn: Katholiek Studiecentrum - Ambo, 1983, 167 pp., H. Obdeijn (eds. - Gary Brana-Shute, Barry B. Levine, Benjy Lopez: A picaresque tale of emigration and return. Basic Books, 1980. 240 pages, bibliography, no index. - Victoria M. Clara van Groenendael, Günter Spitzing, Das indonesische Schattenspiel Bali - Java - Lombok, Köln: Dumont, 1981, 236 pages, photographs, illustrations, map, tables, glossary, bibliography, index. Dumont-Taschenbücher 110. - Dirk van Dusseldorp, B. Galjart, Participation of the poor in development. Contributions to a seminar. 325 pp. Leiden development studies 2, Institute of cultural and social studies, University of Leiden, Leiden 1982., D. Buys (eds. - C. van Dijk, R. de Bruin, Islam en nationalisme in door Japan bezet Indonesië: 1942-1945, ‘s-Gravenhage: Staatsuitgeverij, 1982. Rijksinstituut voor Oorlogsdocumentatie, Cahiers over Nederland en de Tweede Wereldoorlog, nr. 3. - R. Hagesteijn, H.B. Sarkar, Literary heritage of Southeast Asia. Calcutta, Firma KLM Private Limited, 265 pages. - M. Hekker, S. Price, Afro-American arts of the Suriname rain forest. University of California Press, Berkeley/Los Angelos/London, 1981. 237 pp. Maps, Ill., R. Price (eds. - M. Hekker, S.R. Siregar, Adat, Islam and Christianity in a Batak Homeland. Athens, Ohio 1981. Papers in International studies, Southeast Asia series no. 57, Ohio University. 108 pp. - P.E. de Josselin de Jong, Wazir-Jahan Begum Karim, Ma’ Betisék concepts of living things, 1981. New Jersey: Athlone Press. London school of economics monographs on social anthropology no. 54. xv, 270 pp., 3 maps, 6 figs., 11 tables. - Peter Kloos, Paul Alexander, Sri Lanka Fishermen. Rural capitalism and peasant society. Canberra, Australian National University Monographs no. 7, 1982, 328 pp. - Peter Kloos, James Brow, Vedda villages of Anuradhapura. The

  17. Book Reviews

    Directory of Open Access Journals (Sweden)

    R.A. Römer

    1963-10-01

    Full Text Available - A.J.C. Lach de Bére, Fernand van Langenhove, Consciences Tribales et Nationales en Afrique Noire. Institut Royal des Relations Internationales, Bruxelles. Martinus Nijhoff, ‘s-Gravenhage, 1960; 444 blz. - J.H. Scherer, A.H.J. Prins, The Swahili-speaking peoples of Zanzibar and the E. African Coast (Arabs, Shirazi and Swahili. Ethnographic Survey of Africa: East Central Africa, part XII. Uitgave van het International African Institute, London, 1961. 143 pp., m. kaart. - P. Driessens, Carol Brubaker, Geesten van het woud. Servire Luxe Pockets nr. 66. Servire, Den Haag 1963. 175 pp., 24 foto’s. - Joh. J. Hanrath, Indonesian Economics. The concept of dualism in theory and policy. Den Haag (W. van Hoeve 1961. 443 pp. - W. Ph. Coolhaas, H.R.C. Wright, East-Indian economic problems of the age of Cornwallis and Raffles. Luzac, London, 1961; 271 pp. - H.J. de Graaf, M.A.P. Meilink-Roelofsz, Asian trade and European influence in the Indonesian Archipelago between 1500 and about 1630. Academisch Proefschrift Amsterdam (S.U.. M. Nijhoff, ‘s-Gravenhage 1962. 471 pp. - Logemann, Herbert Feith, The decline of constitutional democracy in Indonesia. Cornell University Press, Ithaca, New York, 1962. XX en 608 blz. - F.D.K. Bosch, G. Coedés, Les peuples de la péninsule indochinoise. 228 pp., 16 pl., 1 carte; Ed. Dunod, Paris, 1962. - L. Sluimers, Sirdar Ikbal Ali Shah, Viet-nam. London, Octagon Press, 1960. XV, 232 blz., krt. - L. Sluimers, J.G. Keyes, A bibliography of North Vietnamese Publications in the Cornell University Library. Ithaca, Cornell University, 1962. Data paper: Number 47. Southeast Asia Program. Department of Asian Studies. Cornell University. X, 116 blz., X. - A.F.P. Hulsewé, G.P. Oery, The Man-Shu (Book of the Southern Barbarians, translated by Gordon H. Luce, edited by G.P. Oery; Data Paper Nr. 44, Southeast Asia Program, Dept. of Far Eastern Studies, Cornell Univ., Ithaca, N.Y.; 1961. (X + 116 pp., 1 map. - C.H.M. Palm, Felix M

  18. Book Reviews

    Directory of Open Access Journals (Sweden)

    Danker H. Schaareman

    1980-01-01

    Full Text Available - H.J.M. Claessen, Jan van Bremen, Symposion. Tijdschrift voor Maatschappijwetenschap. Onder redactie van Jan van Bremen, Cees Cruson, Helle Snel, Jojada Verrips, Willem Wolters en Ton Zwaan. Uitgave: Stichting voor Maatschappijwetenschappelijk Onderzoek., Cees Cruson, Helle Snel (eds. - H.J.M. Claessen, Neil Lifuka, Logs in the current of the sea. Neil Lifuka’s story of Kioa and the Vaitupu colonists. Edited and introduced by Klaus-Friedrich Koch. With a foreword by Professor H.E. Maude. Cambridge, Mass.: Langdon Associates Press. 1978. - H.J.M. Claessen, R.R. Nayacakalou, Leadership in Fiji. 1975. Melbourne etc.: Oxford University Press. 170 pp. Appendices, tables, notes. - H.J.M. Claessen, Michael W. Young, The ethnography of Malinowski; The Trobriand Islands 1915-1918. London: Routledge and Kegan Paul, 1979. Bibliography, Index, illustrations. - P.E. de Josselin de Jong, G.B. Milner, Natural symbols in South East Asia. School of Oriental and African Studies, London 1978. 181 p., 13 plates. - P. Kloos, G.N. Appell, Ethical dilemmas in anthropological inquiry: A case book, Waltham (Mass., Crossroads Press, 1978, xii + 291 pp. - David S. Moyer, M.B. Hooker, A concise legal history of South-East Asia. Oxford: Clarendon Press, 1978. 289 pp. - J.G. Oosten, Henri J.M. Claessen, The early state. Mouton Publishers. The Hague, The Netherlands 1978. XII + 690 pages., P. Skalník (eds. - J.G. Oosten, Jean Poirier, Ethnologie Régionale 2. Asie-Amérique-Mascareignes. Sous la direction de Jean Poirier. Encyclopédie de la Pleiade. Gallimard, Paris 1978. - J.G. Oosten, A. de Ruyter, Een speurtocht naar het denken. Een inleiding tot het structuralisme van Claude Lévi Strauss. Van Gorcum & Comp. N.V., Assen 1979. Serie: Terreinverkenningen in de Culturele Anthropologie, nr. 16. - Anton Ploeg, Raymond C. Kelly, Etoro Social Structure. A study in structural contradiction. Foreword by Marshall Sahlins. The University of Michigan Press. Ann Arbor, 1974, 1977

  19. Book Reviews

    Directory of Open Access Journals (Sweden)

    Redactie KITLV

    2004-01-01

    Jeroen Kemperman. Leiden: KITLV Press, 2002, 570 pp. [Verhandelingen 206.] -Gerry van Klinken, Grayson Lloyd ,Indonesia today; Challenges of history. Singapore: Institute of Southeast Asian studies, 2001, 359 pp., Shannon Smith (eds -Johanna van Reenen, Frédéric Durand, Timor Lorosa'e, pays au carrefour de l'Asie et du Pacifique; Un atlas géo-historique. Marne-la-Vallée: Presses Universitaires de Marne-la-Vallée, 2002, 208 pp. -William R. Roff, Mona Abaza, Debates on Islam and knowledge in Malaysia and Egypt; Shifting worlds. London: RoutledgeCurzon, 2002, xix + 304 pp. -Mariëtte van Selm, Chr. van Fraassen ,G.E. Rumphius, De Ambonse eilanden onder de VOC, zoals opgetekend in 'De Ambonse landbeschrijving'. Utrecht: Landelijk Steunpunt Educatie Molukkers, 2002, 254 pp., H. Straver (eds -K. Thirumaran, Prema-Chandra Athukorala, Crisis and recovery in Malaysia; The role of capital controls. Cheltenham: Elgar, 2001, xii + 159 pp. -K. Thirumaran, John Hilley, Malaysia; Mahathirism, hegemony and the new opposition. London: Zed books, 2001, xiii + 305 pp. -Reina van der Wiel, Damien Kingsbury ,Foreign devils and other journalists. Clayton VIC: Monash Asia Institute, 2000, vi + 277 pp. [Monash papers on Southeast Asia 52.], Eric Loo, Patricia Payne (eds -Jennifer Fraser, Philip Yampolsky, Music of Indonesia. Washington DC: Smithsonian Folkways recordings, 1991-2000, 20 compact discs plus a CD of selections from the series, Discover Indonesia. All with accompanying booklets. -Robert Wessing, Nicola Tannenbaum ,Founders' cults in Southeast Asia; Ancestors, polity, and identity. New Haven CT: Yale University Southeast Asian studies, 2003, xi + 373 pp. [Yale Southeast Asia studies Monograph 52.], Cornelia Ann Kammerer (eds -Robert Wessing, Henri Chambert-Loir ,The potent dead; Ancestors, saints and heroes in contemporary Indonesia. Crows Nest, New South Wales: Allen and Unwin, Honolulu: University of Hawai'i Press, 2002, xxvi + 243 pp. [Southeast Asia publications series

  20. Book Reviews

    Directory of Open Access Journals (Sweden)

    Redactie KITLV

    2005-01-01

    Full Text Available -Monika Arnez, Niels Mulder, Southeast Asian images; Towards civil society? Chiang Mai: Silkworm Books, 2003, ix + 253 pp. -Adriaan Bedner, Connie Carter, Eyes on the prize; Law and economic development in Singapore. The Hague: Kluwer Law International, xviii + 307 pp. [The London-Leiden series on law, administration and development 7.] -Amrit Gomperts, J.R. van Diessen ,Grote atlas van Nederlands Oost-Indië/Comprehensive atlas of the Netherlands East Indies. Zierikzee: Asia Maior, Utrecht: Koninklijk Nederlands Aardrijkskundig Genootschap (KNAG, 2004, 480 pp. (editors, with the collaboration of R.C.M. Braam, W. Leijnse, P.A. Levi, J.J. Reijnders, R.P.G.A. Voskuil and M.P.B. Ziellemans, F.J. Ormeling (eds -Stuart R. Harrop, Adriaan Bedner ,Towards integrated environmental law in Indonesia? Leiden: Research school CNWS, School of Asian, African and Amerindian studies, 2003, 161 pp. [CNWS publications 127.], Nicole Niessen (eds -David Henley, Paul H. Kratoska ,Locating Southeast Asia: Geographies of knowledge and politics of space. Singapore: Singapore University Press, 2005, xi + 326 pp., Remco Raben, Henk Schulte Nordholt (eds -Gerry van Klinken, Anthony J. Langlois, The politics of justice and human rights; Southeast Asia and universalist theory. Cambridge: Cambridge University Press, 2001, xi + 214 pp. [Cambridge Asia-Pacific studies.] -Koh Keng We, Jurrien van Goor, Prelude to colonialism; The Dutch in Asia. Hilversum: Verloren, 2004, 127 pp. -Lim Beng Soon, Thomas H. Slone, Prokem; An analysis of a Jakartan slang. Oakland: Masalai Press, 2003, 95 pp. -Lim Beng Soon, Neil Khor Jin Keong ,The Penang Po Leung Kuk; Chinese women, prostitution and a welfare organisation. Kuala Lumpur; The Malaysian branch of the Royal Asiatic society (MBRAS, 2004, VII + 181 pp., Khoo Keat Siew (eds -Dick van der Meij, J. Thomas Lindblad ,Macht en majesteit; Opstellen voor Cees Fasseur bij zijn afscheid als hoogleraar in de geschiedenis van Indonesië aan de

  1. Writing a book review.

    Science.gov (United States)

    Bryson, David; Hudson, Robert

    2017-04-01

    Book reviews are a good way to get started with writing for a journal and this Learning and CPD activity takes you through the process of understanding the aims of book review, undertaking practice pieces through to reviewing a book and advice on the dos and don'ts of book reviewing.

  2. Book Reviews

    Directory of Open Access Journals (Sweden)

    Mary Somers Heidhues

    1992-07-01

    Full Text Available - Jet Bakels, Robert Layton, The anthropology of art. Cambridge: Cambridge University Press, 1991, 258 pp. - J.M.S. Baljon, Herman Leonard Beck, De Islam in Nederland: Romancing religion? [Inaugurele rede theologische faculteit Tilburg 14.2.1992.] Tilburg: Tilburg University Press 1992. - R.H. Barnes, J.D.M. Platenkamp, North Halmahera: Non-Austronesian Languages, Austronesian cultures?, Lecture presented to the Oosters Genootschap in Nederland at Leiden on 23 May 1989, Leiden: Oosters Genootschap in Nederland, 1990. 33 pp. - Hans Borkent, Directory of Southeast Asianists in the Pacific Northwest. Compiled by: Northwest Regional Consortium for Southeast Asian Studies. Seattle, WA: University of Washington [et al.], 1990. 108 pp. - Roy Ellen, Frans Hüsken, Cognation and social organization in Southeast Asia. Verhandelingen van het Koninklijk Instituut voor Taal-, Land- en Volkenkunde 145. Leiden: KITLV Press, 1991, 221 pp. figs. tables, index., Jeremy Kemp (eds. - C. de Jonge, Huub J.W.M. Boelaars, Indonesianisasi. Het omvormingsproces van de katholieke kerk in Indonesië tot de Indonesische katholieke kerk, Kerk en Theologie in Context, 13, Kampen: Kok, 1991, ix + 472 pp. - Nico de Jonge, Gregory Forth, Space and place in eastern Indonesia, University of Kent at Canterbury, Centre of South-east Asian Studies (Occasional Paper no. 16 1991. 85 pp., ills. - J. Kommers, Bernard Juillerat, Oedipe chasseur. Une mythologie du sujet en Nouvelle-Guinée, P.U.F., Le fil rouge, section 1 Psychanalyse. Paris, 1991. - Gerco Kroes, Signe Howell, Society and cosmos, the Chewong of Peninsular Malaysia, University of Chicago Press, 1989, xv + 294 pp. - Daniel S. Lev, S. Pompe, Indonesian Law 1949-1989: A bibliography of foreign-language materials with brief commentaries on the law, Van Vollenhoven Institute for Law and Administration in Non-Western Countries. Nijhoff, 1992. - A. M. Luyendijk-Elshout, H. den Hertog, De militair geneeskundige verzorging

  3. 1000 Solved Problems in Classical Physics An Exercise Book

    CERN Document Server

    Kamal, Ahmad A

    2011-01-01

    This book basically caters to the needs of undergraduate and graduate physics students in classical physics, especially Classical Mechanics and Electricity and Electromagnetism. Lecturers/Tutors may use it as a resource book. The contents of the book are based on the syllabi currently used in the undergraduate courses in the USA, U.K., and other countries. The book consists of 15 chapters, each one beginning with a brief but adequate summary and necessary formulas and Line diagrams followed by a variety of typical problems useful for assignments and exams. Detailed solutions are provided at the end of each chapter.

  4. Book Reviews

    Directory of Open Access Journals (Sweden)

    Redactie KITLV

    1993-07-01

    Full Text Available -Gesa Mackenthun, Stephen Greenblatt, Marvelous Possessions: The wonder of the New World. Chicago: University of Chicago Press, 1991. ix + 202 pp. -Peter Redfield, Peter Hulme ,Wild majesty: Encounters with Caribs from Columbus to the present day. An Anthology. Oxford: Oxford University Press, 1992. x + 369 pp., Neil L. Whitehead (eds -Michel R. Doortmont, Philip D. Curtin, The rise and fall of the plantation complex: Essays in Atlantic history. New York: Cambridge University Press, 1990. xi + 222 pp. -Roderick A. McDonald, Hilary McD.Beckles, A history of Barbados: From Amerindian settlement to nation-state. Cambridge: Cambridge University Press, 1990. xv + 224 pp. -Gertrude J. Fraser, Hilary McD.Beckles, Natural rebels; A social history of enslaved black women in Barbados. New Brunswick NJ and London: Rutgers University Press and Zed Books, 1990 and 1989. ix + 197 pp. -Bridget Brereton, Thomas C. Holt, The problem of freedom: Race, labor, and politics in Jamaica and Britain, 1832-1938. Baltimore: John Hopkins University Press, 1991. xxxi + 517 pp. -Peter C. Emmer, A. Meredith John, The plantation slaves of Trinidad, 1783-1816: A mathematical and demographic inquiry. Cambridge: Cambridge University Press, 1988. xvi + 259 pp. -Richard Price, Robert Cohen, Jews in another environment: Surinam in the second half of the eighteenth century. Leiden: E.J. Brill, 1991. xv + 350 pp. -Russell R. Menard, Nigel Tattersfield, The forgotten trade: comprising the log of the Daniel and Henry of 1700 and accounts of the slave trade from the minor ports of England, 1698-1725. London: Jonathan Cape, 1991. ixx + 460 pp. -John D. Garrigus, James E. McClellan III, Colonialism and science: Saint Domingue in the old regime. Baltimore: John Hopkins University Press, 1992. xviii + 393 pp. -Lowell Gudmundson, Richard H. Collin, Theodore Roosevelt's Caribbean: The Panama canal, the Monroe doctrine, and the Latin American context. Baton Rouge: Louisiana State University

  5. Book Reviews

    Directory of Open Access Journals (Sweden)

    Redactie KITLV

    2003-01-01

    Full Text Available -Timothy Barnard, J.M. Gullick, A history of Selangor (1766-1939. Kuala Lumpur: Malaysian branch of the Royal Asiatic Society, 1989, vi + 220 pp. [MBRAS Monograph 28.] -Okke Braadbaart, Michael L. Ross, Timber booms and institutional breakdown in Southeast Asia. Cambridge: Cambridge University Press, 2001, xvi + 237 pp. -H.J.M. Claessen, Patrick Vinton Kirch ,Hawaiki, ancestral Polynesia; An essay in historical anthropology. Cambridge: Cambridge University Press, 2001, xvii + 375 pp., Roger C. Green (eds -Harold Crouch, R.E. Elson, Suharto; A political biography. Cambridge: Cambridge University Press, 2001, xix + 389 pp. -Kees van Dijk, H.W. Arndt ,Southeast Asia's economic crisis; Origins, lessons, and the way forward. Singapore: Institute of Southeast Asian studies, 1999, ix + 182 pp., Hal Hill (eds -Kees van Dijk, Sebastiaan Pompe, De Indonesische algemene verkiezingen 1999. Leiden: KITLV Uitgeverij, 1999, 290 pp. -David van Duuren, Albert G. van Zonneveld, Traditional weapons of the Indonesian archipelago. Leiden: Zwartenkot art books, 2001, 160 pp. -Peter van Eeuwijk, Christian Ph. Josef Lehner, Die Heiler von Samoa. O Le Fofo; Monographie über die Heiler und die Naturheilmethoden in West-Samoa. Frankfurt am Main: Lang, 1999, 234 pp. [Mensch und Gesellschaft 4.] -Hans Hägerdal, Frans Hüsken ,Reading Asia; New research of Asian studies. Richmond: Curzon, 2001, xvi + 338 pp., Dick van der Meij (eds -Terence E. Hays, Jelle Miedema ,Perspectives on the Bird's head of Irian Jaya, Indonesia; Proceedings of the conference, Leiden, 13-17 October 1997. Amsterdam: Rodopi, 1998, xiii + 982 pp. (editors with the assistance of Connie Baak, Cecilia Odé, Rien A.C. Dam (eds -Menno Hekker, Peter Metcalf, They lie, we lie; Getting on with anthropology. London: Routledge, 2002, ix + 155 pp. -David Henley, Foong Kin, Social and behavioural aspects of malaria control; A study among the Murut of Sabah. Phillips, Maine: Borneo research council , 2000, xx

  6. Book Reviews

    Directory of Open Access Journals (Sweden)

    Redactie KITLV

    1993-01-01

    Full Text Available -Louis Allaire, Samuel M. Wilson, Hispaniola: Caribbean chiefdoms in the age of Columbus. Tuscaloosa: University of Alabama Press, 1990. xi + 170 pp. -Douglas Melvin Haynes, Philip D. Curtin, Death by migration: Europe's encounter with the tropical world in the nineteenth century. Cambridge: Cambridge University Press, 1989. xviii + 251 pp. -Dale Tomich, J.H. Galloway, The sugar cane industry: An historical geography from its origins to 1914. Cambridge: Cambridge University Press, 1989. xii + 266 pp. -Myriam Cottias, Dale Tomich, Slavery in the circuit of sugar: Martinique and the world economy, 1830 -1848. Baltimore: John Hopkins University Press, 1990. xiv + 352 pp. -Robert Forster, Pierre Dessalles, La vie d'un colon à la Martinique au XIXe siècle. Pré-senté par Henri de Frémont. Courbevoie: s.n., 1984-1988, four volumes, 1310 pp. -Hilary Beckles, Douglas V. Armstrong, The old village and the great house: An archaeological and historical examination of Drax Hall Plantation, St Ann's Bay, Jamaica. Chicago: University of Illinois Press, 1990. xiii + 393 pp. -John Stewart, John A. Lent, Caribbean popular culture. Bowling Green OH: Bowling Green State University Popular Press, 1990. 157 pp. -W. Marvin Will, Susanne Jonas ,Democracy in Latin America: Visions and realities. New York: Bergin & Garvey Publishers, 1990. viii + 224 pp., Nancy Stein (eds -Forrest D. Colburn, Kathy McAfee, Storm signals: Structural adjustment and development alternatives in the Caribbean. London: Zed books, 1991. xii + 259 pp. -Derwin S. Munroe, Peggy Antrobus ,In the shadows of the sun: Caribbean development alternatives and U.S. policy. Carmen Diana Deere (coordinator, Peter Phillips, Marcia Rivera & Helen Safa. Boulder CO: Westview Press, 1990. xvii + 246 pp., Lynne Bolles, Edwin Melendez (eds -William Roseberry, Louis A. Pérez, Jr., Lords of the mountain: Social banditry and peasant protest in Cuba, 1878-1918. Pittsburgh: University of Pittsburgh Press, 1989

  7. Book Reviews

    Directory of Open Access Journals (Sweden)

    Redactie KITLV

    1994-07-01

    Full Text Available -Peter Hulme, Stephen Greenblatt, New World Encounters. Berkeley: University of California Press, 1993. xviii + 344 pp. -Nigel Rigby, Alan Riach ,The radical imagination: Lectures and talks by Wilson Harris. Liège: Department of English, University of Liège, xx + 126 pp., Mark Williams (eds -Jonathan White, Rei Terada, Derek Walcott's poetry: American Mimicry. Boston: North-eastern University Press, 1992. ix + 260 pp. -Ray A. Kea, John Thornton, Africa and Africans in the making of the Atlantic world, 1400-1680. Cambridge: Cambridge University Press, 1992. xxxviii + 309 pp. -B.W. Higman, Barbara L. Solow, Slavery and the rise of the Atlantic system. Cambridge: Cambridge University Press, 1991. viii + 355 pp. -Sidney W. Mintz, Michael Mullin, Africa in America: Slave acculturation and resistance in the American South and the British Caribbean, 1736-1831. Urbana: University of Illinois Press. 412 pp. -Karen Fog Olwig, Corinna Raddatz, Afrika in Amerika. Hamburg: Hamburgisches Museum für Völkerkunde, 1992. 264 pp. -Lee Haring, William Bascom, African folktales in the new world. Bloomington: Indiana University Press, 1992. xxv + 243 pp. -Frank Jan van Dijk, Dale A. Bisnauth, History of religions in the Caribbean. Kingston: Kingston Publishers, 1989. 225 pp. -Gloria Wekker, Philomena Essed, Everyday racism: Reports from women of two cultures. Alameda CA: Hunter House, 1990. xiii + 288 pp.''Understanding everyday racism: An interdisciplinary theory. Newbury Park CA: Sage, 1991. x + 322 pp. -Deborah S. Rubin, Vron Ware, Beyond the Pale: White women, racism, and history. London: Verso, 1992. xviii + 263 pp. -Michael Hanchard, Peter Wade, Blackness and race mixture: The dynamics of racial identity in Colombia. Baltimore: John Hopkins University Press, 1993. xv + 415 pp. -Rosalie Schwartz, Louis A. Pérez, Jr., Slaves, sugar, & colonial society: Travel accounts of Cuba, 1801-1899. Wilmington DE: SR Books, 1992. xxvi + 259 pp. -Susan Eckstein, Sandor

  8. Book Reviews

    Directory of Open Access Journals (Sweden)

    Redactie KITLV

    1996-07-01

    . xiv + 217 pp., Lou Anne Barclay (eds -Catherine Levesque, Allison Blakely, Blacks in the Dutch world: The evolution of racial imagery in a modern society. Bloomington: Indiana University Press, 1993. xix + 327 pp. -Dennis J. Gayle, Frank Fonda Taylor, 'To hell with paradise': A history of the Jamaican tourist industry. Pittsburgh: University of Pittsburgh Press, 1993. ix + 239 pp. -John P. Homiak, Frank Jan van Dijk, Jahmaica: Rastafari and Jamaican society, 1930-1990. Utrecht: ISOR, 1993. 483 pp. -Peter Mason, Arthur MacGregor, Sir Hans Sloane: Collector, scientist, antiquary, founding Father of the British Museum. London: British Museum Press, 1994. -Philip Morgan, James Walvin, The life and times of Henry Clarke of Jamaica, 1828-1907. London: Frank Cass, 1994. xvi + 155 pp. -Werner Zips, E. Kofi Agorsah, Maroon heritage: Archaeological, ethnographic and historical perspectives. Kingston: Canoe Press, 1994. xx + 210 pp. -Michael Hoenisch, Werner Zips, Schwarze Rebellen: Afrikanisch-karibischer Freiheitskampf in Jamaica. Vienna Promedia, 1993. 301 pp. -Elizabeth McAlister, Paul Farmer, The uses of Haiti. Monroe ME: Common Courage Press, 1994. 432 pp. -Robert Lawless, James Ridgeway, The Haiti files: Decoding the crisis. Washington DC: Essential Books, 1994. 243 pp. -Bernadette Cailler, Michael Dash, Edouard Glissant. Cambridge: Cambridge University Press, 1995. xii + 202 pp. -Peter Hulme, Veronica Marie Gregg, Jean Rhys's historical imagination: Reading and writing the Creole. Chapel Hill: University of North Carolina Press, 1995. xi + 228 pp. -Silvia Kouwenberg, Francis Byrne ,Focus and grammatical relations in Creole languages. Amsterdam/Philadelphia: John Benjamins, 1993. xvi + 329 pp., Donald Winford (eds -John H. McWhorter, Ingo Plag, Sentential complementation in Sranan: On the formation of an English-based Creole language. Tübingen: Max Niemeyer, 1993. ix + 174 pp. -Percy C. Hintzen, Madan M. Gopal, Politics, race, and youth in Guyana. San Francisco: Mellen

  9. Book Reviews

    Directory of Open Access Journals (Sweden)

    J. Bastin

    1982-04-01

    . - F.G.P. Jaquet, H.J. de Graaf, Wonderlijke verhalen uit de Indische historie, ‘s-Gravenhage, Moesson 1981. 173 pp. Ills. - F.G.P. Jaquet, J. Landwehr, De Nederlander uit en thuis; spiegel van het dagelijks leven uit bijzondere zeventiende-eeuwse boeken. Alphen aan den Rijn, Sijthoff, 1981. 200 pp. Ills. - P.E. de Josselin de Jong, Michael G. Peletz, Social history and evolution in the interrelationship of adat and Islam in Rembau, Negeri Sembilan, Research Notes and Discussions Paper no. 27, Institute of Southeast Asian Studies, Singapore 1981. 59 pages. - P.E. de Josselin de Jong, Anthony Reid, Perceptions of the past in Southeast Asia, Heinemann Educational Books for Asian Studies Asociation of Australia, Singapore 1979. 436 pp. Bibliographical Appendix, Index, 3 maps., David Marr (eds. - J.E. van Lohuizen-de Leeuw, J. Bastin, Prints of Southeast Asia in the India Office Library - The East India Company in Malaysia and Indonesia 1786-1824, Her Majesty’s Stationery Office, London, 1979, XIII + 228 pp. including 98 pls., frontispiece in colour., P. Rohatgi (eds. - Anke Niehof, Victor T. King, Essays on Borneo Society, Hull Monographs on South-East Asia 7, Oxford University Press, 1978, 256 pp. - C.H.M. Nooy-Palm, Renato Rosaldo, Ilongot headhunting 1883-1974, a study in society and history. Stanford University Press, Stanford, California, 1980. 313 pp., maps, photographs and diagrams. Chronological and general index. - Els Postel-Coster, Clio Presvelou, The household, women and agricultural development, Proceedings of a symposium organised by the Department of Home Economics, Agricultural University, Wageningen, Miscellaneous Papers 17, 1980, Landbouwhogeschool Wageningen, The Netherlands., Saskia Spijkers-Zwart (eds. - G.J. van Reenen, Claudine Salmon, Les Chinois de Jakarta; Temples et vie collective [The Chinese of Jakarta; Temples and communal life], Etudes insulindiennes - Archipel 1, Association Archipel, Paris, 1980 (deuxième impression, xxviii + 358 pp

  10. Book Reviews

    Directory of Open Access Journals (Sweden)

    Janet Rodenburg

    1992-04-01

    Full Text Available - Leonard Y. Andaya, H.A. Poeze, Excursies in Celebes; Een bundel bijdragen bij het afscheid van J. Noorduyn als directeur-secretaris van het Koninklijk Instituut voor Taal-, Land- en Volkenkunde. Leiden: KITLV Uitgeverij, 1991, 348 pp., P. Schoorl (eds. - Anne Booth, Adrian Clemens, Changing economy in Indonesia Volume 12b; Regional patterns in foreign trade 1911-40. Amsterdam: Royal Tropical Institute, 1992., J.Thomas Lindblad, Jeroen Touwen (eds. - A.P. Borsboom, James F. Weiner, The empty place; Poetry space, and being among the Foi of Papua New Guinea. Bloomington: Indiana University Press, 1991. - Martin van Bruinessen, Ozay Mehmet, Islamic identity and development; Studies of the Islamic periphery. London and New York: Routledge, 1990 (cheap paperback edition: Kula Lumpur: Forum, 1990, 259 pp. - H.J.M. Claessen, Timothy Earle, Chiefdoms: power, economy, and ideology. A school of American research book. Cambridge: Cambridge University Press, 1991. 341 pp., bibliography, maps, figs. - H.J.M. Claessen, Henk Schulte Nordholt, State, village, and ritual in Bali; A historical perspective. (Comparitive Asian studies 7. Amsterdam: VU University press for the centre for Asian studies Amsterdam, 1991. 50 pp. - B. Dahm, Ruby R. Paredes, Philippine colonial democracy. (Monograph series 32/Yale University Southeast Asia studies. New Haven: Yale Center for international and Asia studies, 1988, 166 pp. - Eve Danziger, Bambi B. Schieffelin, The give and take of everyday life; Language socialization of Kaluli children. (Studies in the social and cultural foundations of language 9. Cambridge: Cambridge University Press, 1991. - Roy Ellen, David Hicks, Kinship and religion in Eastern Indonesia. (Gothenburg studies in social anthropology 12. Gothenburg: Acta Universitatis Gothoburgensis, 1990, viii 132 pp., maps, figs, tbls. - Paul van der Grijp, Pierre Lemonnier, Guerres et festins; Paix, échanges et competition dans les highlands de Nouvelle

  11. Book Reviews

    Directory of Open Access Journals (Sweden)

    Redactie KITLV

    2004-07-01

    Full Text Available -Bill Maurer, Mimi Sheller, Consuming the Caribbean: From Arawaks to Zombies. New York: Routledge, 2003. ix + 252 pp. -Norman E. Whitten, Jr., Richard Price ,The root of roots: Or, how Afro-American anthropology got its start. Chicago: Prickly Paradigm Press/University of Chicago Press, 2003. 91 pp., Sally Price (eds -Holly Snyder, Paolo Bernardini ,The Jews and the expansion of Europe to the West, 1450-1800. New York: Berghahn Books, 2001. xv + 567 pp., Norman Fiering (eds -Bridget Brereton, Seymour Drescher, The mighty experiment: Free labor versus slavery in British emancipation. New York: Oxford University Press, 2002. 307 pp. -Jean Besson, Kathleen E.A. Monteith ,Jamaica in slavery and freedom: History, heritage and culture. Kingston; University of the West Indies Press, 2002. xx + 391 pp., Glen Richards (eds -Michaeline A. Crichlow, Jean Besson, Martha Brae's two histories: European expansion and Caribbean culture-building in Jamaica. Chapel Hill: University of North Carolina Press, 2002. xxxi + 393 pp. -Christopher Schmidt-Nowara, Joseph C. Dorsey, Slave traffic in the age of abolition: Puerto Rico, West Africa, and the Non-Hispanic Caribbean, 1815-1859. Gainesville: University Press of Florida, 2003. xvii + 311 pp. -Arnold R. Highfield, Erik Gobel, A guide to sources for the history of the Danish West Indies (U.S. Virgin Islands, 1671-1917. Denmark: University Press of Southern Denmark, 2002. 350 pp. -Sue Peabody, David Patrick Geggus, Haitian revolutionary studies. Bloomington: Indiana University Press, 2002. xii + 334 pp. -Gerdès Fleurant, Elizabeth McAlister, Rara! Vodou, power, and performance in Haiti and its Diaspora. Berkeley: University of California Press, 2002. xviii + 259 pp. and CD demo. -Michiel Baud, Ernesto Sagás ,The Dominican people: A documentary history. Princeton NJ: Marcus Wiener, 2003. xiii + 278 pp., Orlando Inoa (eds -Samuel Martínez, Richard Lee Turits, Foundations of despotism: Peasants, the Trujillo regime

  12. Book Review:

    Science.gov (United States)

    Sanders, J. H.

    1984-01-01

    The NATO Advanced Study Institute held at Erice, Sicily, in November 1981 brought together specialists in precise measurement to present a tutorial introduction to quantum metrology and the measurement of the fundamental physical constants. Ever since the evolution of experimental physics as a scientific pursuit the measurement of the values of quantities accepted to be constants of nature has commanded the attention of some of the world's most accomplished workers in this field. Their efforts to seek out the sources of systematic error and to reduce the random errors have produced significant advances in techniques and a continual interest in their results from users and critics: as Raymond T Birge, who pioneered the evaluation of the 'best' values of the constants from the available measurements, observed (perhaps with tongue-in-cheek) "it is the continual variation in the values of these quantities that furnishes most of the interest in the subject". Long before the recognition of the fundamental constants the measurement of mass, length and time grew as a matter of necessity in organized communities, especially in agriculture, commerce and navigation. The adoption of standards, first local, then national, and now international, was a natural consequence. It is particularly relevant that the published proceedings of the NATO school opens with a historical survey by Pierre Giacomo of the Bureau International des Poids et Mesures, which places the subsequent papers in perspective. Measurements which realize the standards of length and time, and those from which values of the fundamental constants are derived, are of such a nature that a considerable background knowledge of physics is needed for their understanding. (The principle of the caesium frequency standard and the physics of the Josephson junction are a long haul from Michelson's measurement of the speed of light and the Millikan oil drop experiment familiar in the school books.) With this in mind, George

  13. Book Reviews

    Directory of Open Access Journals (Sweden)

    Joseph Aquilina

    1976-01-01

    .J. Zoetmulder, Himansu Bhusan Sarkar, Corpus of the inscriptions of Java (Corpus Inscriptionum Javanicorum (up to 928 A.D., K.L. Mukhopadhyay, Calcutta, 1972. Vol. I 314 pp., Vol. II 359 pp. - J.G. Oosten, Wilhelmina van Wetering, Hekserij bij de Djuka. Een sociologische benadering. Academisch proefschrift, gestencilde uitgave, 1973. - Willem F.L. Buschkens, Richard Price, Maroon societies, rebel slave communities in the Americas. Anchor Books, Anchor Press/Doubleday Garden City, New York 1973. 429 pag., 7 ill.

  14. Book Reviews

    Directory of Open Access Journals (Sweden)

    Redactie KITLV

    1994-01-01

    Full Text Available -Peter Hulme, Simon Gikandi, Writing in limbo: Modernism and Caribbean literature. Ithaca: Cornell University Press, 1992. x + 260 pp. -Charles V. Carnegie, Alistair Hennessy, Intellectuals in the twentieth-century Caribbean (Volume 1 - Spectre of the new class: The Commonwealth Caribbean. London: Macmillan, 1992. xvii 204 pp. -Nigel Rigby, Anne Walmsley, The Caribbean artists movement, 1966-1972: A literary and cultural history. London: New Beacon Books, 1992. xx + 356 pp. -Carl Pedersen, Tyrone Tillery, Claude McKay: A black poet's struggle for identity. Amherst: University of Massachusetts Press, 1992. xii + 235 pp. -Simone Dreyfus, Irving Rouse, The Tainos: Rise and decline of the people who greeted Columbus. New Haven: Yale University Press, 1992. xii + 211 pp. -Louis Allaire, Antonio M. Stevens-Arroyo, Cave of the Jagua: The mythological world of the Taino. Alburquerque: University of New Mexico Press, 1988. xiii + 282 pp. -Irving Rouse, William F. Keegan, The people who discovered Columbus: The prehistory of the Bahamas. Gainesville: University of Florida Press, 1992. xx + 279 pp. -Neil L. Whitehead, Philip P. Boucher, Cannibal encounters: Europeans and Island Caribs, 1492-1763. Baltimore: John Hopkins University Press, 1992. xii + 217 pp. -Peter Kloos, Kaliña, des amérindiens à Paris: Photographies du prince Roland. Présentées par Gérard Collomb. Paris: Créaphis, 1992. 119 pp. -Maureen Warner-Lewis, Alan Gregor Cobley ,The African-Caribbean connection: Historical and cultural perspectives. Bridgetown, Barbados: Department of History, University of the West Indies, Cave Hill, 1990. viii + 171 pp., Alvin Thompson (eds -H. Hoetink, Jean-Luc Bonniol, La couleur comme maléfice: une illustration créole de la généalogie des 'Blancs' et des 'Noirs'. Paris: Albin Michel, 1992. 304 pp. -Michael Aceto, Richard Price ,Two evenings in Saramaka. Chicago and London: University of Chicago Press, 1991. xvi + 417 pp., Sally Price (eds -Jorge P

  15. Book Reviews

    Directory of Open Access Journals (Sweden)

    R. de Ridder

    1986-01-01

    (50 pp. - R. de Ridder, Dennis Tedlock, The spoken word and the work of interpretation, Philadelphia: University of Pennsylvania Press, 1983. ix + 365 pp., 8 ill. - R. de Ridder, Dennis Tedlock, Popol Vuh, The definitive edition of the Mayan Book of the Dawn of Life and the Glories of Gods and Kings, New York: Simon and Schuster, 1985. 380 pp., 32 ill. - G. van Roon, Dietmar Rothermund, Die Peripherie in der Weltwirtschaftskrise: Afrika, Asien und Lateinamerika 1929-1939, Paderborn: Ferdinand Schýningh, 1983, 295 pp. - Thilo C. Schadeberg, Gýnter Dabitz, Geschichte der erforschung der Nuba-Berge, Arbeiten aus dem Seminar fýr Výlkerkunde der Johann Wolfgang Goethe-Universitýt Frankfurt am Main, Band 17, Wiesbaden: Franz Steiner Verlag, 1985. 280 pp., maps, tables, illus. - L. van Vroonhoven, Ger van Roon, Derde Wereld in depressie, Leiden: Nijhoff, 1985, 139 p. - Wim van Zanten, Nigel Phillips, Sijobang, sung narrative poetry of West Sumatra, Cambridge Studies in Oral and Literate Culture, no. 1, Cambridge: Cambridge University Press, 1981. xi + 255 pp., photos, texts and translations, short glossary of Minangkabau words, Bibliography, index.

  16. Research Brief.

    Science.gov (United States)

    Schoenfelder, Erin; McCabe, Connor; Fife, Aurora; Herzig, Lisa; Ahrens, Kym

    2017-01-01

    Adolescents with ADHD are at risk of functional problems that may be mitigated by consistent ADHD treatment. This study pilots a brief intervention for adolescents with ADHD and their parents to increase treatment knowledge and family motivation to seek treatment. The 3-hr curriculum was developed by a multidisciplinary team and included psychoeducation, goal setting, and motivational interviewing. Fifteen adolescents and 20 caregivers participated in the workshop, completed pre- and post-test assessments, and reported on acceptability. Acceptability and satisfaction with the intervention were high. Perceived knowledge of ADHD increased post intervention; stigma was unchanged. Parents reported more acceptability of stimulant medications and less willingness to use special diets or cognitive games. Family feedback informed modifications to the curriculum. The Teen ADHD Workshop is a feasible and acceptable intervention to increase knowledge of ADHD and evidence-based treatments. Further research will evaluate effects on treatment participation.

  17. Books Are Good Friends

    Institute of Scientific and Technical Information of China (English)

    2012-01-01

    Books are our friends because they are bridges to knowledge.Knowledge is valuable because it enriches our life and brings us happiness.Almost all great men in the history of mankind loved books.We have every reason to believe it is the knowledge in books that led them to success.There is no genius without books.Because books give them knowledge and knowledge gives them

  18. Swift/BAT and Fermi/GBM observations of SGR J1935+2154 bursts

    Science.gov (United States)

    Lin, Lin

    2016-07-01

    SGR J1935+2154 is a new member of the magnetar family. It was discovered from a short burst which triggered Swift/BAT on 2014 July 5. In 2015 February, the source was detected in the burst active episode again which lasted for about 11 days. We searched for magnetar burst using Bayesian Blocks method through Swift/BAT and Fermi/GBM observations, and totally found 27 events including 3 in 2014 and 24 in 2015. In this talk we will present the result of our detailed analysis of the temporal and spectral properties of these short bursts, and briefly discuss the connection between burst activity and the persistent emission of the source.

  19. Book Reviews

    Directory of Open Access Journals (Sweden)

    Redactie KITLV

    1992-01-01

    studies. New Haven, 1990. xiii + 369 pp., W.J. O’Malley, A. Weidemann (eds. - Gisele de Meur, F. Tjon Sie Fat, Representing kinship; Simple models of elementary structures. 1990. (Doctoral thesis. Leiden, published by the author. - Toon van Meijl, Maurice Godelier, Big men and great men; Personifications of power in Melanesia, Cambridge/Paris: Cambridge University Press/Editions de la maison des sciences de l’Homme, 1991, xviii, 328 pp., maps, tables, figures, bibliography, index., Marilyn Strathern (eds. - J.A. de Moor, B.A. Hussainmiya, Orang rejimen; The Malays of the Ceylon rifle regiment. Bangi: Universiti Kebangsaan Malaysia, 1990, 185 pp. - Pieter Muysken, J.M.W. Verhaar, Melanesian pidgin and tok pisin; Studies in language companion series 20. Amsterdam: Benjamins, 1990, xiv + 409 pp. - Niels Mulder, Paul Voogt, Thailand. Amsterdam/’s-Gravenhage: Koninklijk Instituut voor de Tropen/NOVIB, 1991. 70 pp. + kaart, slappe kaft., Han ten Brummelhuis, Irene Stengs (eds. - Ton van Naerssen, George Cho, The Malaysian economy; Spatial perspectives. London: Routledge. 1990, 300 pp. - Julianti Parani, J.R. van Diessen, Jakarta/Batavia. Het centrum van het Nederlandse koloniale rijk in Azië en zijn cultuurhistorische nalatenschap. Cantecleer Kunst - Reisgidsen. De Bilt: Cantecleer, 1989. 343 pp. - A. Ploeg, Christopher J. Healey, Pioneers of the mountain forest, University of Sydney, 1985, Oceania Monographs no. 29, v + 64 pp., plates, figures, maps. - Els Postel-Coster, Carla Risseeuw, The fish don’t talk about the water; Gender transformation, power and resistance among women in Sri Lanka, Leiden: E.J.Brill, 1988, 415 pp., also published as Gender transformation, power and resistance among women in Sri Lanka; The fish don’t speak about the water, New Delhi: Manohar Book service, 1991. Ca. 400 pp., - Willem van Schendel, Mya Tan, Myanmar dilemmas and options; The challenge of economic transition in the 1990’s. Singapore: Institute of Southeast Asian studies, 1990

  20. CADrx for GBM Brain Tumors: Predicting Treatment Response from Changes in Diffusion-Weighted MRI

    Directory of Open Access Journals (Sweden)

    Matthew S. Brown

    2009-11-01

    Full Text Available The goal of this study was to develop a computer-aided therapeutic response (CADrx system for early prediction of drug treatment response for glioblastoma multiforme (GBM brain tumors with diffusion weighted (DW MR images. In conventional Macdonald assessment, tumor response is assessed nine weeks or more post-treatment. However, we will investigate the ability of DW-MRI to assess response earlier, at five weeks post treatment. The apparent diffusion coefficient (ADC map, calculated from DW images, has been shown to reveal changes in the tumor’s microenvironment preceding morphologic tumor changes. ADC values in treated brain tumors could theoretically both increase due to the cell kill (and thus reduced cell density and decrease due to inhibition of edema. In this study, we investigated the effectiveness of features that quantify changes from pre- and post-treatment tumor ADC histograms to detect treatment response. There are three parts to this study: first, tumor regions were segmented on T1w contrast enhanced images by Otsu’s thresholding method, and mapped from T1w images onto ADC images by a 3D region of interest (ROI mapping tool using DICOM header information; second, ADC histograms of the tumor region were extracted from both pre- and five weeks post-treatment scans, and fitted by a two-component Gaussian mixture model (GMM. The GMM features as well as standard histogram-based features were extracted. Finally, supervised machine learning techniques were applied for classification of responders or non-responders. The approach was evaluated with a dataset of 85 patients with GBM under chemotherapy, in which 39 responded and 46 did not, based on tumor volume reduction. We compared adaBoost, random forest and support vector machine classification algorithms, using ten-fold cross validation, resulting in the best accuracy of 69.41% and the corresponding area under the curve (Az of 0.70.

  1. Searching the Gamma-ray Sky for Counterparts to Gravitational Wave Sources: Fermi GBM and LAT Observations of LVT151012 and GW151226

    CERN Document Server

    Racusin, J L; Goldstein, A; Connaughton, V; Wilson-Hodge, C A; Jenke, P; Blackburn, L; Briggs, M S; Broida, J; Camp, J; Christensen, N; Hui, C M; Littenberg, T; Shawhan, P; Singer, L; Veitch, J; Bhat, P N; Cleveland, W; Fitzpatrick, G; Gibby, M H; von Kienlin, A; McBreen, S; Mailyan, B; Meegan, C A; Paciesas, W S; Preece, R D; Roberts, O J; Stanbro, M; Veres, P; Zhang, B -B; Ackermann, M; Albert, A; Atwood, W B; Axelsson, M; Baldini, L; Ballet, J; Barbiellini, G; Baring, M G; Bastieri, D; Bellazzini, R; Bissaldi, E; Blandford, R D; Bloom, E D; Bonino, R; Bregeon, J; Bruel, P; Buson, S; Caliandro, G A; Cameron, R A; Caputo, R; Caragiulo, M; Caraveo, P A; Cavazzuti, E; Charles, E; Chiang, J; Ciprini, S; Costanza, F; Cuoco, A; Cutini, S; D'Ammando, F; de Palma, F; Desiante, R; Digel, S W; Di Lalla, N; Di Mauro, M; Di Venere, L; Drell, P S; Favuzzi, C; Ferrara, E C; Focke, W B; Fukazawa, Y; Funk, S; Fusco, P; Gargano, F; Gasparrini, D; Giglietto, N; Gill, R; Giroletti, M; Glanzman, T; Granot, J; Green, D; Grove, J E; Guillemot, L; Guiriec, S; Harding, A K; Jogler, T; Johannesson, G; Kamae, T; Kensei, S; Kocevski, D; Kuss, M; Larsson, S; Latronico, L; Li, J; Longo, F; Loparco, F; Lubrano, P; Magill, J D; Maldera, S; Malyshev, D; McEnery, J E; Michelson, P F; Mizuno, T; Morselli, A; Moskalenko, I V; Negro, M; Nuss, E; Omodei, N; Orienti, M; Orlando, E; Ormes, J F; Paneque, D; Perkins, J S; Pesce-Rollins, M; Piron, F; Pivato, G; Porter, T A; Principe, G; Raino, S; Rando, R; Razzano, M; Razzaque, S; Reimer, A; Reimer, O; Parkinson, P M Saz; Scargle, J D; Sgro, C; Simone, D; Siskind, E J; Smith, D A; Spada, F; Spinelli, P; Suson, D J; Tajima, H; Thayer, J B; Torres, D F; Troja, E; Uchiyama, Y; Vianello, G; Wood, K S; Wood, M

    2016-01-01

    We present the Fermi Gamma-ray Burst Monitor (GBM) and Large Area Telescope (LAT) observations of the LIGO binary black hole merger event GW151226 and candi- date LVT151012. No candidate electromagnetic counterparts were detected by either the GBM or LAT. We present a detailed analysis of the GBM and LAT data over a range of timescales from seconds to years, using automated pipelines and new techniques for char- acterizing the upper limits across a large area of the sky. Due to the partial GBM and LAT coverage of the large LIGO localization regions at the trigger times for both events, dif- ferences in source distances and masses, as well as the uncertain degree to which emission from these sources could be beamed, these non-detections cannot be used to constrain the variety of theoretical models recently applied to explain the candidate GBM counterpart to GW150914.

  2. DISTRIBUTION OF GBM HEPARAN-SULFATE PROTEOGLYCAN CORE PROTEIN AND SIDE-CHAINS IN HUMAN GLOMERULAR-DISEASES

    NARCIS (Netherlands)

    VANDENBORN, J; VANDENHEUVEL, LPWJ; BAKKER, MAH; VEERKAMP, JH; ASSMANN, KJM; WEENING, JJ; BERDEN, JHM

    1993-01-01

    Using monoclonal antibodies (mAbs) recognizing either the core protein or the heparan sulfate (HS) side chain of human GBM heparan sulfate proteoglycan (HSPG), we investigated their glomerular distribution on cryostat sections of human kidney tissues. The study involved 95 biopsies comprising twelve

  3. Response assessment of bevacizumab therapy in GBM with integrated 11C-MET-PET/MRI: a feasibility study.

    Science.gov (United States)

    Deuschl, Cornelius; Moenninghoff, Christoph; Goericke, Sophia; Kirchner, Julian; Köppen, Susanne; Binse, Ina; Poeppel, Thorsten D; Quick, Harald H; Forsting, Michael; Umutlu, Lale; Herrmann, Ken; Hense, Joerg; Schlamann, Marc

    2017-08-01

    The objective of this study was to evaluate the potential of integrated 11C-MET PET/MR for response assessment of relapsed glioblastoma (GBM) receiving bevacizumab treatment. Eleven consecutive patients with relapsed GBM were enrolled for an integrated 11C-MET PET/MRI at baseline and at follow-up. Treatment response for MRI was evaluated according to Response Assessment in Neuro-oncology (RANO) criteria and integrated 11C-MET PET was assessed by the T/N ratio. MRI showed no patient with complete response (CR), six of 11 patients with PR, four of 11 patients with SD, and one of 11 patients with progressive disease (PD). PET revealed metabolic response in five of the six patients with partial response (PR) and in two of the four patients with stable disease (SD), whereas metabolic non-response was detected in one of the six patients with PR, in two of the four patients with SD, and in the one patient with PD. Morphological imaging was predictive for PFS and OS when response was defined as CR, PR, SD, and non-response as PD. Metabolic imaging was predictive when using T/N ratio reduction of >25 as discriminator. Based on the morphologic and metabolic findings of this study a proposal for applying integrated PET/MRI for treatment response in relapsed GBM was developed, which was significantly predictive for PFS and OS (P = 0.010 respectively 0,029, log). This study demonstrates the potential of integrated 11C-MET-PET/MRI for response assessment of GBM and the utility of combined assessment of morphologic and metabolic information with the proposal for assessing relapsed GBM.

  4. MAXIMIZATION OF DNA DAMAGE TO MGMT(+ EGFR(+ GBM CELLS USING OPTIMAL COMBINATION OF TEMOZOLOMIDE-ANTI EGFR MONOCLONAL ANTIBODY NIMOTUZUMAB

    Directory of Open Access Journals (Sweden)

    M. A. M. Inggas

    2015-09-01

    Full Text Available Background: Glioblastoma multiforme (GBM is the most aggressive primary brain tumor in adultswith dismal prognosis due to the unavailability of an effective therapy. Up to now, there had been no definitive studies published on EGFR inhibition therapy as a chemosensitizer for GBM therapy using Temozolomide (TMZ. This study aims to reveal the most effective method and timing to administer TMZ-anti EGFR targeted therapy which causes maximal DNA damage on GBM cells.Methods: Various regimens of anti EGFR monoclonal antibody Nimotuzumab (NMZ was administered in different combinations with TMZ, performed on U87MG MGMT(+ EGFR(+ cells. The effectiveness of the combinations were evaluated by measuring yH2AX levels which reflects the degree of DNA damage. One-way Anova and LSD tests were performed to determine the effects of each treatment with p<0.05. Results and discussion: the mean SD of yH2AX of each treatment was: 11,90±1,25 for the control group; 29.33±1.91 for NMZ alone; 28.13±1.58 for TMZ alone; 41.53±3.51 for concurrent use; 35.67 ±2.65 for NMZ after 24 hours TMZ; 31.87±2.94 for NMZ after 48 hours TMZ; 39.57±4.2 for TMZ after 24 hours NMZ; and 35.93 ±3.56 for TMZ after 48 hours NMZ. The administration of TMZ concurrent with or after 24 hours NMZ gives the highest amount of DNA damage to GBM cells. Conclusion: The administration of Nimotuzumab targeted therapy up to 24 hours before Temozolomide chemotherapy has been proven to be effective in maximizing the amount of DNA damage done to GBM cells in vitro. 

  5. Advertising books: a linguistic analysis of blurbs

    OpenAIRE

    Mª Lluïsa Gea Valor

    2005-01-01

    The purpose of this paper is to present a preliminary approach to the study of blurbs, brief texts traditionally displayed on bookcovers, and nowadays also on the Internet, which provide information about a book to potential readers. This study focuses on four of the most widelyknown publishing and bookselling companies in the English-speaking world: Penguin, Ballantine, Routledge, and Barnes & Noble, and analyses more than 60 blurbs displayed on their web sites. The study indicates that blur...

  6. BookFinder.com

    CERN Document Server

    BookFinder.com is produced by the bibliophiles at 13th Generation Media of Berkeley, California. Our goal is to provide fellow readers unbiased realtime information about books available online. Rather than selling books ourselves (does the world rea Amazon.com wannabe?), we've teamed up with over 15,000 of the finest booksellers online to bring you the largest book catalog available anywhere, either online or offline.

  7. Companionship of Books

    Institute of Scientific and Technical Information of China (English)

    薛美娟

    2012-01-01

    A man may usually be known by the books he reads as well as by the company he keeps; for there is a companionship of books as well as of men~ and one should always live in the best company, whether it be of books or of men.

  8. Thinking outside the Book

    Science.gov (United States)

    Eaton, Dolores E.

    2012-01-01

    A title, a cover, and pages with "substance" bound together--this is what the author's eighth-grade students decided were the essential elements of a book. There could be more, but no less. In art, one does judge a book by its cover. In this article, the author describes how her students created their books. (Contains 1 online resource.)

  9. The New Russian Book

    DEFF Research Database (Denmark)

    Pristed, Birgitte Beck

    print culture to a post-Soviet book market. It delivers a profound and critical exploration of Russian visual imaginary of classic, popular, and contemporary prose. Among all the carelessly bungled covers of mass-published post-Soviet series the study identifies gems from experimental designers......This book takes up the obtrusive problem of visual representation of fiction in contemporary Russian book design. By analyzing a broad variety of book covers, the study offers an absolutely unique material that illustrates a radically changing notion of literature in the transformation of Soviet...... the fields of Russian studies, contemporary book and media history, art, design, and visual studies....

  10. Love British Books 2012

    OpenAIRE

    Middleton, Paul; Puzzovio, Carolyn

    2012-01-01

    The book is a catalogue of an exhibition of British books to be held in Armenia in June 2012 at the 'Armenian Society for Cultural Relations with Foreign Countries'. This is an event arranged with the Armenian Ministry of Culture as part of the UNESCO: 'Yerevan, International Book Capital 2012' & the Armenian 2012 celebrations to mark the 500th anniversary of the first printed book in the Armenian language. The catalogue describes all the books in the exhibition, with a photograph of each and...

  11. BOOK REVIEW: Two Books about FRBR, Compared

    Directory of Open Access Journals (Sweden)

    Christine Schwartz

    2008-09-01

    Full Text Available This article reviews 2 books on FRBR published in the past year. Although both books aim to be introductions to FRBR, their approaches are very different. One is sort of a FRBR study guide with commentary, the other a collection of essays. Robert Maxwell's book, FRBR: A Guide for the Perplexed, takes the study guide approach. Arlene Taylor edited Understanding FRBR: What It Is and How It Will Affect Our Retrieval Tools, a book of essays about FRBR and FRAD, written by cataloging experts, aimed at a broader audience, not just the cataloging specialist. The first seven chapters lay out the basics: introductions to FRBR and FRAD, FRBR research, FRBR and the history of cataloging, FRBR and RDA. These chapters provide an excellent introduction for those new to FRBR. The last seven chapters each look at different types of resources in relation to FRBR.

  12. The Fermi GBM Gamma-Ray Burst Spectral Catalog: Four Years Of Data

    CERN Document Server

    Gruber, David; von Ahlefeld, Victoria Weller; Bhat, P Narayana; Bissaldi, Elisabetta; Briggs, Michael S; Byrne, Dave; Cleveland, William H; Connaughton, Valerie; Fishman, Gerald J; Fitzpatrick, Gerard; Foley, Suzanne; Gibby, Melissa; Giles, Misty M; Greiner, Jochen; Guiriec, Sylvain; van der Horst, Alexander J; von Kienlin, Andreas; Kouveliotou, Chryssa; Layden, Emily; Lin, Lin; Meegan, Charles A; McGlynn, Sinéad; Paciesas, William S; Pelassa, Véronique; Preece, Robert D; Rau, Arne; Wilson-Hodge, Colleen A; Xiong, Shaolin; Yu, Hoi-Fung

    2014-01-01

    In this catalog we present the updated set of spectral analyses of GRBs detected by the Fermi Gamma-Ray Burst Monitor (GBM) during its first four years of operation. It contains two types of spectra, time-integrated spectral fits and spectral fits at the brightest time bin, from 943 triggered GRBs. Four different spectral models were fitted to the data, resulting in a compendium of more than 7500 spectra. The analysis was performed similarly, but not identically to Goldstein et al. 2012. All 487 GRBs from the first two years have been re-fitted using the same methodology as that of the 456 GRBs in years three and four. We describe, in detail, our procedure and criteria for the analysis, and present the results in the form of parameter distributions both for the observer-frame and rest-frame quantities. The data files containing the complete results are available from the High-Energy Astrophysics Science Archive Research Center (HEASARC).

  13. Restriction spectrum imaging of bevacizumab-related necrosis in a patient with GBM

    Directory of Open Access Journals (Sweden)

    Nikdokht eFarid

    2013-09-01

    Full Text Available Importance:With the increasing use of antiangiogenic agents in the treatment of high grade gliomas, we are becoming increasingly aware of distinctive imaging findings seen in a subset of patients treated with these agents. Of particular interest is the development of regions of marked and persistent restricted diffusion. We describe a case with histopathologic validation, confirming that this region of restricted diffusion represents necrosis and not viable tumor. Observations:We present a case report of a 52-year-old man with GBM treated with temozolomide, radiation, and concurrent bevacizumab following gross total resection. The patient underwent sequential MRI's which included restriction-spectrum imaging (RSI, an advanced diffusion-weighted imaging (DWI technique, and MR perfusion. Following surgery, the patient developed an area of restricted diffusion on RSI which became larger and more confluent over the next several months. Marked signal intensity on RSI and very low cerebral blood volume (CBV on MR perfusion led us to favor bevacizumab-related necrosis over recurrent tumor. Subsequent histopathologic evaluation confirmed coagulative necrosis.Conclusions and Relevance:Our report increases the number of pathologically-proven cases of bevacizumab-related necrosis in the literature from three to four. Furthermore, our case demonstrates this phenomenon on RSI, which has been shown to have good sensitivity to restricted diffusion.

  14. GBM Volumetry using the 3D Slicer Medical Image Computing Platform

    Science.gov (United States)

    Egger, Jan; Kapur, Tina; Fedorov, Andriy; Pieper, Steve; Miller, James V.; Veeraraghavan, Harini; Freisleben, Bernd; Golby, Alexandra J.; Nimsky, Christopher; Kikinis, Ron

    2013-01-01

    Volumetric change in glioblastoma multiforme (GBM) over time is a critical factor in treatment decisions. Typically, the tumor volume is computed on a slice-by-slice basis using MRI scans obtained at regular intervals. (3D)Slicer – a free platform for biomedical research – provides an alternative to this manual slice-by-slice segmentation process, which is significantly faster and requires less user interaction. In this study, 4 physicians segmented GBMs in 10 patients, once using the competitive region-growing based GrowCut segmentation module of Slicer, and once purely by drawing boundaries completely manually on a slice-by-slice basis. Furthermore, we provide a variability analysis for three physicians for 12 GBMs. The time required for GrowCut segmentation was on an average 61% of the time required for a pure manual segmentation. A comparison of Slicer-based segmentation with manual slice-by-slice segmentation resulted in a Dice Similarity Coefficient of 88.43 ± 5.23% and a Hausdorff Distance of 2.32 ± 5.23 mm. PMID:23455483

  15. GBM Monitoring of Cyg X-1 During the Recent State Transition

    CERN Document Server

    Case, G L; Cherry, M L; Camero-Arranz, A; Finger, M; Jenke, P; Wilson-Hodge, C A; Chaplin, V

    2011-01-01

    Cygnus X-1 is a high-mass x-ray binary with a black hole compact object. It is normally extremely bright in hard x-rays and low energy gamma rays and resides in the canonical hard spectral state. Recently, however, Cyg X-1 made a transition to the canonical soft state, with a rise in the soft x-ray flux and a decrease in the flux in the hard x-ray and low energy gamma-ray energy bands. We have been using the Gamma-Ray Burst Monitor on Fermi to monitor the fluxes of a number of sources in the 8--1000 keV energy range, including Cyg X-1. We present light curves of Cyg X-1 showing the flux decrease in hard x-ray and low energy gamma-ray energy bands during the state transition as well as the several long flares observed in these higher energies during the soft state. We also present preliminary spectra from GBM for the pre-transition state, showing the spectral evolution to the soft state, and the post-transition state.

  16. Testing the anisotropy in the angular distribution of $Fermi$/GBM gamma-ray bursts

    CERN Document Server

    Tarnopolski, Mariusz

    2015-01-01

    Gamma-ray bursts (GRBs) were confirmed to be of extragalactic origin due to their isotropic angular distribution, combined with the fact that they exhibited an intensity distribution that deviated strongly from the $-3/2$ power law. This finding was later confirmed with the first redshift, equal to at least $z=0.835$, measured for GRB970508. Despite this result, the data from $CGRO$/BATSE and $Swift$/BAT indicate that long GRBs are indeed distributed isotropically, but the distribution of short GRBs is anisotropic. $Fermi$/GBM has detected 1669 GRBs up to date, and their sky distribution is examined in this paper. A number of statistical tests is applied: nearest neighbour analysis, fractal dimension, dipole and quadrupole moments of the distribution function decomposed into spherical harmonics, binomial test, and the two point angular correlation function. Monte Carlo benchmark testing of each test is performed in order to evaluate its reliability. It is found that short GRBs are distributed anisotropically ...

  17. A phase II study of bevacizumab and erlotinib after radiation and temozolomide in MGMT unmethylated GBM patients

    Science.gov (United States)

    Raizer, J. J.; Giglio, P.; Hu, J.; Groves, M.; Merrell, R.; Conrad, C.; Phuphanich, S.; Puduvalli, V. K.; Loghin, M.; Paleologos, N.; Yuan, Y.; Liu, D.; Rademaker, A.; Yung, W. K.; Vaillant, B.; Rudnick, J.; Chamberlain, M.; Vick, N.; Grimm, S.; Tremont-Lukats, I. W.; De Groot, J.; Aldape, K.; Gilbert, M. R.

    2016-01-01

    Survival for glioblastoma (GBM) patients with an unmethyated MGMT promoter in their tumor is generally worse than methylated MGMT tumors, as temozolomide (TMZ) response is limited. How to better treat patients with unmethylated MGMT is unknown. We performed a trial combining erlotinib and bevacizumab in unmethylated GBM patients after completion of radiation (RT) and TMZ. GBM patients with an unmethylated MGMT promoter were trial eligible. Patient received standard RT (60 Gy) and TMZ (75 mg/m2 × 6 weeks) after surgical resection of their tumor. After completion of RT they started erlotinib 150 mg daily and bevacizumab 10 mg/kg every 2 weeks until progression. Imaging evaluations occurred every 8 weeks. The primary endpoint was overall survival. Of the 48 unmethylated patients enrolled, 46 were evaluable (29 men and 17 women); median age was 55.5 years (29–75) and median KPS was 90 (70–100). All patients completed RT with TMZ. The median number of cycles (1 cycle was 4 weeks) was 8 (2–47). Forty-one patients either progressed or died with a median progression free survival of 9.2 months. At a follow up of 33 months the median overall survival was 13.2 months. There were no unexpected toxicities and most observed toxicities were categorized as CTC grade 1 or 2. The combination of erlotinib and bevacizumab is tolerable but did not meet our primary endpoint of increasing survival. Importantly, more trials are needed to find better therapies for GBM patients with an unmethylated MGMT promoter. PMID:26476729

  18. Test of the Weak Equivalence Principle using LIGO observations of GW150914 and Fermi observations of GBM transient 150914

    Directory of Open Access Journals (Sweden)

    Molin Liu

    2017-07-01

    Full Text Available About 0.4 s after the Laser Interferometer Gravitational-Wave Observatory (LIGO detected a transient gravitational-wave (GW signal GW150914, the Fermi Gamma-ray Burst Monitor (GBM also found a weak electromagnetic transient (GBM transient 150914. Time and location coincidences favor a possible association between GW150904 and GBM transient 150914. Under this possible association, we adopt Fermi's electromagnetic (EM localization and derive constraints on possible violations of the Weak Equivalence Principle (WEP from the observations of two events. Our calculations are based on four comparisons: (1 The first is the comparison of the initial GWs detected at the two LIGO sites. From the different polarizations of these initial GWs, we obtain a limit on any difference in the parametrized post-Newtonian (PPN parameter Δγ≲10−10. (2 The second is a comparison of GWs and possible EM waves. Using a traditional super-Eddington accretion model for GBM transient 150914, we again obtain an upper limit Δγ≲10−10. Compared with previous results for photons and neutrinos, our limits are five orders of magnitude stronger than those from PeV neutrinos in blazar flares, and seven orders stronger than those from MeV neutrinos in SN1987A. (3 The third is a comparison of GWs with different frequencies in the range [35 Hz, 250 Hz]. (4 The fourth is a comparison of EM waves with different energies in the range [1 keV, 10 MeV]. These last two comparisons lead to an even stronger limit, Δγ≲10−8. Our results highlight the potential of multi-messenger signals exploiting different emission channels to strengthen existing tests of the WEP.

  19. Improved limits on sterile neutrino dark matter from full-sky observations by the Fermi-GBM

    CERN Document Server

    Horiuchi, Shunsaku; Gaskins, Jennifer M; Smith, Miles; Preece, Robert

    2015-01-01

    For the first time, we use the Gamma-ray Burst Monitor (GBM) on-board the Fermi satellite to search for sterile neutrino decay lines in the energy range 10-25 keV corresponding to sterile neutrino mass range 20-50 keV. This energy range has been out of reach of traditional X-ray satellites such as Chandra, Suzaku, XMM-Newton, and gamma-ray satellites such as INTEGRAL. Furthermore, the extremely wide field of view of the GBM opens a large fraction of the Milky Way dark matter halo to be probed. We start with 1601 days worth of GBM data, implement stringent data cuts, and perform two simple line search analyses on the reduced data: in the first, the line flux is limited without background modeling, and in the second, the background is modeled as a power-law. We find no significant excess lines in both our searches. We set new limits on sterile neutrino mixing angles, improving on previous limits by approximately an order of magnitude. Better understanding of detector and astrophysical backgrounds, as well as de...

  20. HDAC inhibitors enhance the lethality of low dose salinomycin in parental and stem-like GBM cells.

    Science.gov (United States)

    Booth, Laurence; Roberts, Jane L; Conley, Adam; Cruickshanks, Nichola; Ridder, Thomas; Grant, Steven; Poklepovic, Andrew; Dent, Paul

    2014-03-01

    The present studies determined whether the antibiotic salinomycin interacted with HDAC inhibitors to kill primary human GBM cells. Regardless of PTEN, ERBB1, or p53 mutational status salinomycin interacted with HDAC inhibitors in a synergistic fashion to kill GBM cells. Inhibition of CD95/Caspase 8 or of CD95/RIP-1/AIF signaling suppressed killing by the drug combination. Salinomycin increased the levels of autophagosomes that correlated with increased p62 and LC3II levels; valproate co-treatment correlated with reduced LC3II and p62 expression, and increased caspase 3 cleavage. Molecular inhibition of autophagosome formation was protective against drug exposure. The drug combination enhanced eIF2α phosphorylation and decreased expression of MCL-1 and phosphorylation of mTOR and p70 S6K. Activation of p70 S6K or mTOR promoted cell survival in the face of combined drug exposure. Overexpression of BCL-XL or c-FLIP-s was protective. Collectively our data demonstrate that the lethality of low nanomolar concentrations of salinomycin are enhanced by HDAC inhibitors in GBM cells and that increased death receptor signaling together with reduced mitochondrial function are causal in the combinatorial drug necro-apoptotic killing effect.

  1. Gamma Knife Surgery as Monotherapy with Clinically Relevant Doses Prolongs Survival in a Human GBM Xenograft Model

    Directory of Open Access Journals (Sweden)

    Bente Sandvei Skeie

    2013-01-01

    Full Text Available Object. Gamma knife surgery (GKS may be used for recurring glioblastomas (GBMs. However, patients have then usually undergone multimodal treatment, which makes it difficult to specifically validate GKS independent of established treatments. Thus, we developed an experimental brain tumor model to assess the efficacy and radiotoxicity associated with GKS. Methods. GBM xenografts were implanted intracerebrally in nude rats, and engraftment was confirmed with MRI. The rats were allocated to GKS, with margin doses of 12 Gy or 18 Gy, or to no treatment. Survival time was recorded, tumor sections were examined, and radiotoxicity was evaluated in a behavioral open field test. Results. In the first series, survival from the time of implantation was 96 days in treated rats and 72 days in controls (P<0.001. In a second experiment, survival was 72 days in the treatment group versus 54 days in controls (P<0.006. Polynuclear macrophages and fibrosis was seen in groups subjected to GKS. Untreated rats with GBM xenografts displayed less mobility than GKS-treated animals in the open field test 4 weeks after treatment (P=0.04. Conclusion. GKS administered with clinically relevant doses prolongs survival in rats harboring GBM xenografts, and the associated toxicity is mild.

  2. Three years of Fermi GBM Earth Occultation Monitoring: Observations of Hard X-ray/Soft Gamma-Ray Sources

    CERN Document Server

    Wilson-Hodge, Colleen A; Cherry, Michael L; Rodi, James; Camero-Arranz, Ascension; Jenke, Peter; Chaplin, Vandiver; Beklen, Elif; Finger, Mark; Bhat, Narayan; Briggs, Michael S; Connaughton, Valerie; Greiner, Jochen; Kippen, R Marc; Meegan, Charles A; Paciesas, William S; Preece, Robert; von Kienlin, Andreas

    2012-01-01

    The Gamma ray Burst Monitor (GBM) on board Fermi has been providing continuous data to the astronomical community since 2008 August 12. In this paper we present the results of the analysis of the first three years of these continuous data using the Earth occultation technique to monitor a catalog of 209 sources. From this catalog, we detect 102 sources, including 41 low-mass X-ray binary/neutron star systems, 33 high-mass X-ray binary neutron star systems, 12 black hole binaries, 12 active galaxies, 2 other sources, plus the Crab Nebula, and the Sun. Nine of these sources are detected in the 100-300 keV band, including seven black-hole binaries, the active galaxy Cen A, and the Crab. The Crab and Cyg X-1 are also detected in the 300-500 keV band. GBM provides complementary data to other sky-monitors below 100 keV and is the only all-sky monitor above 100 keV. Up-to-date light curves for all of the catalog sources can be found at http://heastro.phys.lsu.edu/gbm/.

  3. The optical identifcation of events with poorly defined locations: The case of the Fermi GBM GRB140801A

    CERN Document Server

    Lipunov, V M; Pruzhinskaya, M V; Postigo, A de Ugarte; Pelassa, V; Tsvetkova, A E; Sokolov, I V; Kann, D A; Xu, Dong; Gorbovskoy, E S; Krushinski, V V; Kornilov, V G; Balanutsa, P V; Boronina, S V; Budnev, N M; Cano, Z; Castro-Tirado, A J; Chazov, V V; Connaughton, V; Delvaux, C; Frederiks, D D; Fynbo, J F U; Gabovich, A V; Goldstein, A; Greiner, J; Gress, O A; Ivanov, K I; Jakobsson, P; Klose, S; Knust, F; Komarova, V N; Konstantinov, E; Krylov, A V; Kuvshinov, D A; Kuznetsov, A S; Lipunova, G V; Moskvitin, A S; Pal'shin, V D; Pandey, S B; Poleshchuk, V A; Schmidl, S; Sergienko, Yu P; Sinyakov, E V; Schulze, S; Sokolov, V V; Sokolova, T N; Sparre, M; Thone, C C; Tlatov, A G; Tyurina, N V; Ulanov, M V; Yazev, S A; Yurkov, V V

    2015-01-01

    We report the early discovery of the optical afterglow of gamma-ray burst (GRB) 140801A in the 137 deg$^2$ 3-$\\sigma$ error-box of the Fermi Gamma-ray Burst Monitor (GBM). MASTER is the only observatory that automatically react to all Fermi alerts. GRB 140801A is one of the few GRBs whose optical counterpart was discovered solely from its GBM localization. The optical afterglow of GRB 140801A was found by MASTER Global Robotic Net 53 sec after receiving the alert, making it the fastest optical detection of a GRB from a GBM error-box. Spectroscopy obtained with the 10.4-m Gran Telescopio Canarias and the 6-m BTA of SAO RAS reveals a redshift of $z=1.32$. We performed optical and near-infrared photometry of GRB 140801A using different telescopes with apertures ranging from 0.4-m to 10.4-m. GRB 140801A is a typical burst in many ways. The rest-frame bolometric isotropic energy release and peak energy of the burst is $E_\\mathrm{iso} = 5.54_{-0.24}^{+0.26} \\times 10^{52}$ erg and $E_\\mathrm{p, rest}\\simeq280$ keV,...

  4. The Problem with Briefs, in Brief

    Science.gov (United States)

    Conaway, Carrie L.

    2013-01-01

    Policy briefs written by academics--the kind typically published in "Education Finance and Policy"--should be a crucial source of information for policy makers. Yet too frequently these briefs fail to garner the consideration they deserve. Their authors are too focused on the potential objections of their fellow academics, who are…

  5. The Problem with Briefs, in Brief

    Science.gov (United States)

    Conaway, Carrie L.

    2013-01-01

    Policy briefs written by academics--the kind typically published in "Education Finance and Policy"--should be a crucial source of information for policy makers. Yet too frequently these briefs fail to garner the consideration they deserve. Their authors are too focused on the potential objections of their fellow academics, who are…

  6. English Book Club

    CERN Multimedia

    English Book Club

    2012-01-01

    The CERN English Book Club will hold its 2012 AGM at 17h30 on Monday 5th March in the club rooms (club barrack 564). Club members are invited to attend. Any members wishing to add points on to the agenda should contact one of the committee before February 27th. The English Book Club has a collection of over 4500 English language books, mostly general fiction with a sprinkling of nonfiction and children’s books. New books are purchased regularly and the books are shelved in our club room which is accessible to members at all times. Membership is open to all (staff and external) and there is a special tariff for short term students. See the club’s website at http://cern.ch/englishbookclub for more details.

  7. English Book Club

    CERN Multimedia

    CERN English Book Club

    2010-01-01

    AGM  --  AGM  -- 2010 --  AGM  --  AGM The CERN ENGLISH BOOK CLUB will hold its 2010 AGM at 18h00 on Monday November 22nd in the club rooms (club barrack 564). Club members are invited to attend. Any members wishing to add points on to the agenda should contact one of the committee before November 12th. AGM  --  AGM  -- 2010 --  AGM  --  AGM The English Book Club has a collection of over 4500 English language books, mostly general fiction with a sprinkling of nonfiction and children’s books. New books are purchased regularly and the books are shelved in our club room which is accessible to members at all times. Membership is open to all (staff and external) and there is a special tariff for short term students. See the club’s website at http://cern.ch/englishbookclub for more details.  

  8. Software engineer's pocket book

    CERN Document Server

    Tooley, Michael

    2013-01-01

    Software Engineer's Pocket Book provides a concise discussion on various aspects of software engineering. The book is comprised of six chapters that tackle various areas of concerns in software engineering. Chapter 1 discusses software development, and Chapter 2 covers programming languages. Chapter 3 deals with operating systems. The book also tackles discrete mathematics and numerical computation. Data structures and algorithms are also explained. The text will be of great use to individuals involved in the specification, design, development, implementation, testing, maintenance, and qualit

  9. Electrical engineer's reference book

    CERN Document Server

    Laughton, M A

    1985-01-01

    Electrical Engineer's Reference Book, Fourteenth Edition focuses on electrical engineering. The book first discusses units, mathematics, and physical quantities, including the international unit system, physical properties, and electricity. The text also looks at network and control systems analysis. The book examines materials used in electrical engineering. Topics include conducting materials, superconductors, silicon, insulating materials, electrical steels, and soft irons and relay steels. The text underscores electrical metrology and instrumentation, steam-generating plants, turbines

  10. Fast Flux Test Facility (FFTF) Briefing Book 1 Summary

    Energy Technology Data Exchange (ETDEWEB)

    WJ Apley

    1997-12-01

    This report documents the results of evaluations preformed during 1997 to determine what, if an, future role the Fast Flux Test Facility (FFTF) might have in support of the Department of Energy’s tritium productions strategy. An evaluation was also conducted to assess the potential for the FFTF to produce medical isotopes. No safety, environmental, or technical issues associated with producing 1.5 kilograms of tritium per year in the FFTF have been identified that would change the previous evaluations by the Department of Energy, the JASON panel, or Putnam, Hayes & Bartlett. The FFTF can be refitted and restated by July 2002 for a total expenditure of $371 million, with an additional $64 million of startup expense necessary to incorporate the production of medical isotopes. Therapeutic and diagnostic applications of reactor-generated medical isotopes will increase dramatically over the next decade. Essential medical isotopes can be produced in the FFTF simultaneously with tritium production, and while a stand-alone medical isotope mission for the facility cannot be economically justified given current marker conditions, conservative estimates based on a report by Frost &Sullivan indicate that 60% of the annual operational costs (reactor and fuel supply) could be offset by revenues from medical isotope production within 10 yeas of restart. The recommendation of the report is for the Department of Energy to continue to maintain the FFTF in standby and proceed with preparation of appropriate Nations Environmental Policy Act documentation in full consultation with the public to consider the FFTF as an interim tritium production option (1.5 kilograms/year) with a secondary mission of producing medical isotopes.

  11. A Novel GBM Saliency Detection Model Using Multi-Channel MRI.

    Directory of Open Access Journals (Sweden)

    Subhashis Banerjee

    Full Text Available The automatic computerized detection of regions of interest (ROI is an important step in the process of medical image processing and analysis. The reasons are many, and include an increasing amount of available medical imaging data, existence of inter-observer and inter-scanner variability, and to improve the accuracy in automatic detection in order to assist doctors in diagnosing faster and on time. A novel algorithm, based on visual saliency, is developed here for the identification of tumor regions from MR images of the brain. The GBM saliency detection model is designed by taking cue from the concept of visual saliency in natural scenes. A visually salient region is typically rare in an image, and contains highly discriminating information, with attention getting immediately focused upon it. Although color is typically considered as the most important feature in a bottom-up saliency detection model, we circumvent this issue in the inherently gray scale MR framework. We develop a novel pseudo-coloring scheme, based on the three MRI sequences, viz. FLAIR, T2 and T1C (contrast enhanced with Gadolinium. A bottom-up strategy, based on a new pseudo-color distance and spatial distance between image patches, is defined for highlighting the salient regions in the image. This multi-channel representation of the image and saliency detection model help in automatically and quickly isolating the tumor region, for subsequent delineation, as is necessary in medical diagnosis. The effectiveness of the proposed model is evaluated on MRI of 80 subjects from the BRATS database in terms of the saliency map values. Using ground truth of the tumor regions for both high- and low- grade gliomas, the results are compared with four highly referred saliency detection models from literature. In all cases the AUC scores from the ROC analysis are found to be more than 0.999 ± 0.001 over different tumor grades, sizes and positions.

  12. Leguminosae. A source book of characteristics, uses and nodulation

    Energy Technology Data Exchange (ETDEWEB)

    Allen, O.N.; Allen, E.K

    1981-01-01

    Following a review of the nature and occurrence of root nodulation in the family, the main body of the book presents synopses, for each of the 750 known genera, containing information on morphological characteristics, taxonomy, distribution, habitat preferences, and uses (including brief notes on timbers), and lists of known nodulated and non-nodulated species.

  13. Outstanding Science Trade Books for Children in 1989.

    Science.gov (United States)

    Science and Children, 1990

    1990-01-01

    Listed are 100 trade books with brief descriptions and availability information. Categories include animals, biography, space science and astronomy, anthropology and paleontology, life sciences, earth science, conservation, medical and health sciences, physics, technology, and engineering. Criteria for inclusion in this annual list are presented.…

  14. Pairing Books for Learning: The Union of Informational and Fiction

    Science.gov (United States)

    Baer, Allison L.

    2012-01-01

    This article aims to present an annotated bibliography of paired books--one fiction and one informational--about multiple topics in history and social studies that, when read together, can help support students' learning through experiencing the topic from multiple perspectives and voices. It begins with a brief rationale for pairing fiction and…

  15. Fire and Blood: Censorship of Books in China.

    Science.gov (United States)

    Zhang, Wenxian

    1990-01-01

    Reviews the history of censorship of books in China from the earliest Chinese history to 1949. The role of religion and obscenity in censorship are discussed, but the primary focus is on the political use of censorship, including the structure and regulation of censorship in communist China. A brief Chinese chronology is provided. (22…

  16. Old Books and E-Books

    OpenAIRE

    Darnton, Robert

    2007-01-01

    The crisis in academic publishing has reached a point where young scholars in many fields of the humanities may no longer be able to communicate their research in the time-honoured manner - that is, in the form of a traditional codex printed by a university press. Sooner or later, most monographs will probably have to be published on the Internet. What form will they take? A tentative answer to that question is provided by a sketch for an electronic book about publishing and the book trade in...

  17. Give a Book, Take a Book | Poster

    Science.gov (United States)

    Collection has begun for the 15th Annual Book & Media Swap sponsored by the Scientific Library. NCI at Frederick staff can use this opportunity to clear out personal book and DVD shelves of unwanted materials, donate them to the swap, and then receive “new” materials in return. The library staff will collect materials through Tuesday, Oct. 27. Kick-off day for the event is Wednesday, Oct. 28, 10 a.m. to 2 p.m., in the lobby of the Conference Center in Building 549.

  18. El Libro de la Escritura por Pinguino Tinto (The Writing Book, by Inky Penguin).

    Science.gov (United States)

    Padgett, Ron

    Presented completely in Spanish and intended for elementary level students, this book offers 12 writing ideas and several suggestions on how students can make a book using their writing. Each writing idea is presented with a brief description (addressed to the student), several examples of student writing, and a blank page on which to write.…

  19. Assessing the User Experience of E-Books in Academic Libraries

    Science.gov (United States)

    Zhang, Tao; Niu, Xi; Promann, Marlen

    2017-01-01

    We report findings from an assessment of e-book user experience (search and information seeking) from usage data and user tests. The usage data showed that most reading sessions were brief and focused on certain pages, suggesting that users mainly use e-books to find specific information. The user tests found that participants tended to use…

  20. El Libro de la Escritura por Pinguino Tinto (The Writing Book, by Inky Penguin).

    Science.gov (United States)

    Padgett, Ron

    Presented completely in Spanish and intended for elementary level students, this book offers 12 writing ideas and several suggestions on how students can make a book using their writing. Each writing idea is presented with a brief description (addressed to the student), several examples of student writing, and a blank page on which to write.…

  1. Proteolysis breaks tolerance toward intact α345(IV) collagen, eliciting novel anti-GBM autoantibodies specific for α345NC1 hexamers

    Science.gov (United States)

    Olaru, Florina; Wang, Xu-Ping; Luo, Wentian; Ge, Linna; Miner, Jeffrey H; Kleinau, Sandra; Geiger, Xochiquetzal J.; Wasiluk, Andrew; Heidet, Laurence; Kitching, A. Richard; Borza, Dorin-Bogdan

    2012-01-01

    Goodpasture disease is an autoimmune kidney disease mediated by autoAbs against NC1 monomers of α3(IV) collagen that bind to the glomerular basement membrane (GBM), usually causing rapidly progressive glomerulonephritis. We identified a novel type of human IgG4-restricted anti-GBM autoAbs associated with mild non-progressive glomerulonephritis, which specifically targeted α345NC1 hexamers but not α3NC1 monomers. The mechanisms eliciting these anti-GBM autoAbs were investigated in mouse models recapitulating this phenotype. Wild type and FcγRIIB−/− mice immunized with autologous murine GBM NC1 hexamers produced mouse IgG1-restricted autoAbs specific for α345NC1 hexamers, which bound to the GBM in vivo but did not cause glomerulonephritis. In these mice, intact collagen IV from murine GBM was not immunogenic. However, in Col4a3−/− Alport mice, both intact collagen IV and NC1 hexamers from murine GBM elicited IgG antibodies specific for α3α4α5NC1 hexamers, which were not subclass restricted. As heterologous antigen in COL4A3-humanized mice, murine GBM NC1 hexamers elicited mouse IgG1, IgG2a and IgG2b autoAbs specific for α345NC1 hexamers and induced anti-GBM Ab glomerulonephritis. These findings indicate that tolerance toward autologous intact α3α4α5(IV) collagen is established in hosts expressing this antigen, even though autoreactive B cells specific for α345NC1 hexamers are not purged from their repertoire. Proteolysis selectively breaches this tolerance by generating autoimmunogenic α3α4α5NC1 hexamers. This provides a mechanism eliciting autoAbs specific for α345NC1 hexamers, which are restricted to non-inflammatory IgG subclasses and non-nephritogenic. In Alport syndrome, lack of tolerance toward α3α4α5(IV) collagen promotes production of alloantibodies to α345NC1 hexamers, including pro-inflammatory IgG subclasses which mediate post-transplant anti-GBM nephritis. PMID:23303673

  2. 2011 Renewable Energy Data Book (Book)

    Energy Technology Data Exchange (ETDEWEB)

    Gelman, R.

    2012-10-01

    This Renewable Energy Data Book for 2011 provides facts and figures on energy in general, renewable electricity in the United States, global renewable energy development, wind power, solar energy, geothermal power, biopower, hydropower, advanced water power, hydrogen, renewable fuels, and clean energy investments.

  3. 2012 Renewable Energy Data Book (Book)

    Energy Technology Data Exchange (ETDEWEB)

    Gelman, R.

    2013-10-01

    This Renewable Energy Data Book for 2012 provides facts and figures in a graphical format on energy in general, renewable electricity in the United States, global renewable energy development, wind power, solar power, geothermal power, biopower, hydropower, advanced water power, hydrogen, renewable fuels, and clean energy investment.

  4. 2013 Renewable Energy Data Book (Book)

    Energy Technology Data Exchange (ETDEWEB)

    Esterly, S.

    2014-12-01

    This Renewable Energy Data Book for 2013 provides facts and figures on energy in general, renewable electricity in the United States, global renewable energy development, wind power, solar power, geothermal power, biopower, hydropower, advanced water power, hydrogen, renewable fuels, and clean energy investment.

  5. 2010 Renewable Energy Data Book (Book)

    Energy Technology Data Exchange (ETDEWEB)

    Gelman, R.

    2011-10-01

    This Renewable Energy Data Book for 2010 provides facts and figures on energy in general, renewable electricity in the United States, global renewable energy development, wind power, solar energy, geothermal power, biopower, hydropower, advanced water power, hydrogen, renewable fuels, and clean energy investments.

  6. ATLAS Colouring Book

    CERN Multimedia

    Anthony, Katarina

    2016-01-01

    The ATLAS Experiment Colouring Book is a free-to-download educational book, ideal for kids aged 5-9. It aims to introduce children to the field of High-Energy Physics, as well as the work being carried out by the ATLAS Collaboration.

  7. Astronomy books in Spanish

    Science.gov (United States)

    Fierro, Julieta

    Great cultures have created language. They have discovered its strength among other reasons for education. For a long time the Bible was one of the few books available in western culture, its influence is beyond any doubt. Many developing nations have no science books in their mother tongue. They might carry a few translations but these do not convey the local culture so it is harder for students to grasp the concepts and to build on what they know. Books, even if they are extremely simple, should be written in local languages because that will facilitate the conveying of knowledge and the creation of scientific culture. In the books examples that pertain to every day local life must be given, in particular examples that have to do with women. Women play a central role in developing nations by child bearing; if they become literate they will influence enormously the quality of their children's education, in particular their science comprehension. In Mexico a collection that includes astronomy books has recently been edited by the National Council for Culture and Arts. The books are small and light, which encourages middle-school students to carry them around and read them while traveling in public transportation, such as the subway. Every other page is a new subject, that carries illustrations, abstracts and conclusions. The astronomy books are on search for extraterrestrial life, the stars and the universe. These books are distributed nation-wide and are inexpensive. They have been written by Mexican astronomers.

  8. More than Comic Books

    Science.gov (United States)

    Boerman-Cornell, Bill

    2013-01-01

    Graphic novels (book-length fiction or nonfiction narratives told using the conventions of a comic book) bring together text and image in a way that seems to capture students' imaginations. Right now, there is little more than anecdotal research about how graphic novels can be used within specific middle school and high school disciplines. As…

  9. More than Comic Books

    Science.gov (United States)

    Boerman-Cornell, Bill

    2013-01-01

    Graphic novels (book-length fiction or nonfiction narratives told using the conventions of a comic book) bring together text and image in a way that seems to capture students' imaginations. Right now, there is little more than anecdotal research about how graphic novels can be used within specific middle school and high school disciplines. As…

  10. Strawberry Square. Song Book.

    Science.gov (United States)

    Larson, Tom

    Designed to accompany a series of 33 television programs in music education for kindergarten and first grade children, this song book (containing sheet music) correlates with activities in the teacher's guide. Titles of songs included in the book are: Let a Song Tell a Story (short and long versions); If I Had a Hammer; A Happy Street; Let the…

  11. English Book Club

    CERN Multimedia

    English Book Club

    The minutes of the AGM held on Tuesday November 17th can now be found on the club web-site: http://club-englishbookclub.web.cern.ch. A new version of the club’s book data-base is also available on the web: http://club-englishbookclub.web.cern.ch/club-englishbookclub/Export/index.html The last book selection for 2009 is done and the order for the new books has been placed, with luck they will be on the shelves before the end of year break. The English Book Club has a growing collection of over 4500 English language books, mostly general fiction with a sprinkling of nonfiction and children’s books. New books are purchased regularly and the books are shelved in our club room which is accessible to members at all times. Membership is open to all (staff and external) and there is a special tariff for short term students. See the club’s website at http://cern.ch/englishbookclub for more details.

  12. The Book Club Exploded

    Science.gov (United States)

    Hoffert, Barbara

    2006-01-01

    One leader, 12 readers, and a few well-thumbed copies of Jane Austen's "Pride and Prejudice." That is all a book club once required, but this is no longer the case. This article describes how the runaway popularity of book clubs has brought with it a whole new set of possibilities. Thematic discussion? A fiction/nonfiction mix? Videoconferencing?…

  13. Test Scoring [book review].

    Science.gov (United States)

    Meijer, Rob R.

    2003-01-01

    This book discusses how to obtain test scores and, in particular, how to obtain test scores from tests that consist of a combination of multiple choice and open-ended questions. The strength of the book is that scoring solutions are presented for a diversity of real world scoring problems. (SLD)

  14. Why Write Book Reviews?

    Science.gov (United States)

    Obeng-Odoom, Franklin

    2014-01-01

    The pressure to publish or perish or, more recently, to be visible or vanish, marginalises a culture of critical reading and reflection that has historically been the province of book reviews. Today, book reviews are roundly rejected by academic bureaucrats as unimportant, easy to write and hence, easy to get published, mere summaries, uncritical…

  15. The Book of Joshua

    NARCIS (Netherlands)

    Noort, E

    2012-01-01

    "The Book of Joshua contains the papers of the Colloquium Biblicum Lovaniense 2010 on the Book of Joshua and the Land of Israel. Not for the sake of plurality as such, but as a signal of the state of the art in Joshua research in the post-Noth era this volume functions as a platform for different

  16. Books in the Family.

    Science.gov (United States)

    Swinger, Alice K.

    1989-01-01

    Opportunities for parents to encourage reading in the family are noted and ways to enhance the reading experience are discussed, including writing letters to book characters, singing combined with reading aloud, supplementing school subjects with enjoyable reading, sharing books at family gatherings, and using family experiences for book…

  17. Books in Our Future.

    Science.gov (United States)

    Boorstin, Daniel J.

    This study explores the changing role of the book in the future. The report draws on interviews with authors, publishers, booksellers, computer experts, librarians, scientists, educators, and scholars and on the experience of the Library of Congress staff. The first part, "The Culture of the Book: Today and Tomorrow," includes sections…

  18. The Book Club Exploded

    Science.gov (United States)

    Hoffert, Barbara

    2006-01-01

    One leader, 12 readers, and a few well-thumbed copies of Jane Austen's "Pride and Prejudice." That is all a book club once required, but this is no longer the case. This article describes how the runaway popularity of book clubs has brought with it a whole new set of possibilities. Thematic discussion? A fiction/nonfiction mix? Videoconferencing?…

  19. China Connections Reference Book.

    Science.gov (United States)

    Kalat, Marie B.; Hoermann, Elizabeth F.

    This reference book focuses on six aspects of the geography of the People's Republic of China. They are: territory, governing units, population and land use, waterways, land forms, and climates. Designed as a primary reference, the book explains how the Chinese people and their lifestyles are affected by China's geography. Special components…

  20. One book too many

    Directory of Open Access Journals (Sweden)

    Andrej Blatnik

    2008-01-01

    Full Text Available The article is exploring the changes in the communication value of Slovenian book after the year 1991. The shifted (selfunderstanding of the publishing business going from activity of ‘special social importance’to explicitly profit-making activity has not only changed the ways of book production, but also the products themselves. This has influenced also those factors in the communication circuit of the book which still belong to the public sector. Following the example of two bestsellers published in 2008,the author points out the differences in public and market functioning of structurally same books and emphasizes the importance of a conscious choice which positions the adequate product into the communication circuit of the book.

  1. Talking about Books: Karen Hesse.

    Science.gov (United States)

    Beck, Cathy; Gwyn, Linda; Koblitz, Dick; O'Connor, Anne; Pierce, Kathryn Mitchell; Wolf, Susan

    1999-01-01

    Presents an interview with Karen Hesse, author of 12 books of fiction for young, middle, and older readers, and winner of the 1998 Newbery Award. Offers an overview of Hesse's books, organized into picture books, transition chapter books, and novels. Presents a discussion of the themes found in her books, highlighting children's discussion…

  2. Patients double-seropositive for ANCA and anti-GBM antibodies have varied renal survival, frequency of relapse, and outcomes compared to single-seropositive patients.

    Science.gov (United States)

    McAdoo, Stephen P; Tanna, Anisha; Hrušková, Zdenka; Holm, Lisa; Weiner, Maria; Arulkumaran, Nishkantha; Kang, Amy; Satrapová, Veronika; Levy, Jeremy; Ohlsson, Sophie; Tesar, Vladimir; Segelmark, Mårten; Pusey, Charles D

    2017-09-01

    Co-presentation with both ANCA and anti-GBM antibodies is thought to be relatively rare. Current studies of such 'double-positive' cases report small numbers and variable outcomes. To study this further we retrospectively analyzed clinical features and long-term outcomes of a large cohort of 568 contemporary patients with ANCA-associated vasculitis, 41 patients with anti-GBM disease, and 37 double-positive patients with ANCA and anti-GBM disease from four European centers. Double-positive patients shared characteristics of ANCA-associated vasculitis (AAV), such as older age distribution and longer symptom duration before diagnosis, and features of anti-GBM disease, such as severe renal disease and high frequency of lung hemorrhage at presentation. Despite having more evidence of chronic injury on renal biopsy compared to patients with anti-GBM disease, double-positive patients had a greater tendency to recover from being dialysis-dependent after treatment and had intermediate long-term renal survival compared to the single-positive patients. However, overall patient survival was similar in all three groups. Predictors of poor patient survival included advanced age, severe renal failure, and lung hemorrhage at presentation. No single-positive anti-GBM patients experienced disease relapse, whereas approximately half of surviving patients with AAV and double-positive patients had recurrent disease during a median follow-up of 4.8 years. Thus, double-positive patients have a truly hybrid disease phenotype, requiring aggressive early treatment for anti-GBM disease, and careful long-term follow-up and consideration for maintenance immunosuppression for AAV. Since double-positivity appears common, further work is required to define the underlying mechanisms of this association and define optimum treatment strategies. Copyright © 2017 International Society of Nephrology. Published by Elsevier Inc. All rights reserved.

  3. Comprehensive analysis of MGMT promoter methylation: correlation with MGMT expression and clinical response in GBM.

    Directory of Open Access Journals (Sweden)

    Nameeta Shah

    Full Text Available O⁶-methylguanine DNA-methyltransferase (MGMT promoter methylation has been identified as a potential prognostic marker for glioblastoma patients. The relationship between the exact site of promoter methylation and its effect on gene silencing, and the patient's subsequent response to therapy, is still being defined. The aim of this study was to comprehensively characterize cytosine-guanine (CpG dinucleotide methylation across the entire MGMT promoter and to correlate individual CpG site methylation patterns to mRNA expression, protein expression, and progression-free survival. To best identify the specific MGMT promoter region most predictive of gene silencing and response to therapy, we determined the methylation status of all 97 CpG sites in the MGMT promoter in tumor samples from 70 GBM patients using quantitative bisulfite sequencing. We next identified the CpG site specific and regional methylation patterns most predictive of gene silencing and improved progression-free survival. Using this data, we propose a new classification scheme utilizing methylation data from across the entire promoter and show that an analysis based on this approach, which we call 3R classification, is predictive of progression-free survival (HR  = 5.23, 95% CI [2.089-13.097], p<0.0001. To adapt this approach to the clinical setting, we used a methylation-specific multiplex ligation-dependent probe amplification (MS-MLPA test based on the 3R classification and show that this test is both feasible in the clinical setting and predictive of progression free survival (HR  = 3.076, 95% CI [1.301-7.27], p = 0.007. We discuss the potential advantages of a test based on this promoter-wide analysis and compare it to the commonly used methylation-specific PCR test. Further prospective validation of these two methods in a large independent patient cohort will be needed to confirm the added value of promoter wide analysis of MGMT methylation in the clinical

  4. Advertising books: a linguistic analysis of blurbs

    Directory of Open Access Journals (Sweden)

    Mª Lluïsa Gea Valor

    2005-10-01

    Full Text Available The purpose of this paper is to present a preliminary approach to the study of blurbs, brief texts traditionally displayed on bookcovers, and nowadays also on the Internet, which provide information about a book to potential readers. This study focuses on four of the most widelyknown publishing and bookselling companies in the English-speaking world: Penguin, Ballantine, Routledge, and Barnes & Noble, and analyses more than 60 blurbs displayed on their web sites. The study indicates that blurbs may constitute a genre characterised by a definite communicative purpose and by the use of specific linguistic and discourse conventions. Blurbs perform an informative function based on the description of the contents of a book. But this function is secondary to their persuasive purpose, characteristic of advertising discourse, because blurbs recommend the book by means of review extracts from various sources in an attempt to persuade the prospective reader to buy the "product." In order to achieve their communicative purpose, blurbs make use of a wide range of linguistic and discourse conventions typical of advertising discourse: complimenting, elliptical syntactic patterns, the imperative, the address form "you," and what I have called "curiosity arousers," usually in the form of rhetorical questions and excerpts from the book.

  5. Book Presentation | 27 February

    CERN Multimedia

    The CERN Library

    2013-01-01

    "A caccia del bosone di Higgs. Magneti, governi, scienziati e particelle nell'impresa scientifica del secolo" by Luciano Maiani and Romeo Bassoli, published by Mondadori. On Wednesday 27 February Luciano Maiani will present the book "A caccia del bosone di Higgs. Magneti, governi, scienziati e particelle nell'impresa scientifica del secolo". More information here. The presentation will take place in the Council Chamber at 16.00 and will be followed by a debate and book signing. The book will be on sale. You are cordially invited.

  6. Closing the Book

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    @@ When Bertelsmann Direct Group,the music and book direct-marketing arm of German media conglomerate Bertelsmann AG,launched its business in China in 1995,it seemed like a winning idea.The company's book clubs,a catalog mail-order operation offering cut-price books in return for a monthly membership fee,had proven a hugely lucrative business in Europe;and China,with its huge,highly literate population,seemed an ideal market for expansion.

  7. Helping Children Make Transitions between Activities. What Works Briefs.

    Science.gov (United States)

    Ostrosky, M. M.; Jung, E. Y.; Hemmeter, M. L.

    This brief discusses the confusion some young children feel in moving from one activity to another (e.g., bus to classroom, cubbies to book reading, art time to lunch) that often results in frustration and challenging behaviors. The paper provides practical information on a variety of strategies to help preschool children make smooth, independent…

  8. BOOK REVIEW: The Odd Quantum

    Science.gov (United States)

    Reynolds, Helen

    2000-03-01

    The Odd Quantum is aiming to be odd. Falling between being a quantum mechanics textbook and a `popular' science book, it aims to convey something of the substance of quantum mechanics without being overly technical or professional. It does not shy away from the mathematics of the subject or resort solely to analogy and metaphor, as so often is the case. Books aimed at the lay reader tend to take on a particular aspect of quantum mechanics, for example, wave-particle duality, and can do little more than hint at the complexity of the subject. This book is more than a textbook on quantum mechanics; it gives the reader a comprehensive account of history and an appreciation of the nature of quantum mechanics. The introductory chapters deal with the earlier part of the century and the thinking of that time. The approach is familiar, as are the stories that Treiman tells, but he also manages to convey the speed with which ideas changed and the excitement this brought to the physics community. Classical ideas of force and energy are dealt with succinctly but with sufficient depth to set up the reader for what is to come; Maxwell's equations and a brief glimpse at relativity are included. This is followed by a brief description of what the author terms the `old' quantum mechanics, in effect a highly readable tour around black body radiation and spectroscopy and the models of the atom that emerged from them. The `new' quantum mechanics begins about a third of the way through the book, and in a chapter entitled `Foundations' starts gently but rapidly moves into a detailed mathematical treatment. This section, of necessity, relapses into the style of a textbook and covers a lot of ground quickly. It is at this point that the non-specialist popular science readers for whom Treiman has written this book may become a little bemused. Concepts such as non-degeneracy and operators come thick and fast. It is difficult to imagine an educated non-physicist with little mathematical

  9. Phenethyl isothiocyanate alters the gene expression and the levels of protein associated with cell cycle regulation in human glioblastoma GBM 8401 cells.

    Science.gov (United States)

    Chou, Yu-Cheng; Chang, Meng-Ya; Wang, Mei-Jen; Liu, Hsin-Chung; Chang, Shu-Jen; Harnod, Tomor; Hung, Chih-Huang; Lee, Hsu-Tung; Shen, Chiung-Chyi; Chung, Jing-Gung

    2017-01-01

    Glioblastoma is the most common and aggressive primary brain malignancy. Phenethyl isothiocyanate (PEITC), a member of the isothiocyanate family, can induce apoptosis in many human cancer cells. Our previous study disclosed that PEITC induces apoptosis through the extrinsic pathway, dysfunction of mitochondria, reactive oxygen species (ROS)-induced endoplasmic reticulum (ER) stress, and intrinsic (mitochondrial) pathway in human brain glioblastoma multiforme (GBM) 8401 cells. To the best of our knowledge, we first investigated the effects of PEITC on the genetic levels of GBM 8401 cells in vitro. PEITC may induce G0/G1 cell-cycle arrest through affecting the proteins such as cdk2, cyclin E, and p21 in GBM 8401 cells. Many genes associated with cell-cycle regulation of GBM 8401 cells were changed after PEITC treatment: 48 genes were upregulated and 118 were downregulated. The cell-division cycle protein 20 (CDC20), Budding uninhibited by benzimidazole 1 homolog beta (BUB1B), and cyclin B1 were downregulated, and clusterin was upregulated in GBM 8401 cells treated with PEITC. These changes of gene expression can provide the effects of PEITC on the genetic levels and potential biomarkers for glioblastoma. © 2015 Wiley Periodicals, Inc. Environ Toxicol 32: 176-187, 2017.

  10. BC3EE2,9B, a synthetic carbazole derivative, upregulates autophagy and synergistically sensitizes human GBM8901 glioblastoma cells to temozolomide.

    Science.gov (United States)

    Chen, Chien-Min; Syu, Jhih-Pu; Way, Tzong-Der; Huang, Li-Jiau; Kuo, Sheng-Chu; Lin, Chung-Tien; Lin, Chih-Li

    2015-11-01

    Glioblastoma multiforme (GBM) is the most fatal form of human brain cancer. Although temozolomide (TMZ), an oral alkylating chemotherapeutic agent, improves the survival rate, the prognosis of patients with GBM remains poor. Naturally occurring carbazole alkaloids isolated from curry leaves (Murraya koenigii Spreng.) have been shown to possess a wide range of anticancer properties. However, the effects of carbazole derivatives on glioblastoma cells remain poorly understood. In the present study, anti‑glioblastoma profiles of a series of synthetic carbazole derivatives were evaluated in vitro. The most promising derivative in this series was BC3EE2,9B, which showed significant anti‑proliferative effects in GBM8401 and GBM8901 cells. BC3EE2,9B also triggered cell‑cycle arrest, most prominently at the G1 stage, and suppressed glioblastoma cell invasion and migration. Furthermore, BC3EE2,9B induced autophagy‑mediated cell death and synergistically sensitized GBM cells to TMZ cytotoxicity. The possible mechanism underlying BC3EE2,9B‑induced autophagy may involve activation of adenosine monophosphate-activated protein kinase and the attenuation of the Akt and mammalian target of the rapamycin downstream signaling pathway. Taken together, the present results provide molecular evidence for the mode of action governing the ability of BC3EE2,9B to sensitize drug‑resistant glioblastoma cells to the chemotherapeutic agent TMZ.

  11. Adapting to e-books

    CERN Document Server

    Miller, William

    2013-01-01

    Electronic books are now having a major impact on library collections. This book provides models for acquisitions policies and reports on several surveys of faculty and librarian attitudes toward e-books. It discusses issues in acquiring cataloguing and collection development regarding this important new library resource.Its subject matter deals with the different types of e-books, statistical data available for e-book usage, the development of e-book collections, learning environments, integrating e-books into local catalogues, acquisitions and usage monitoring of e-books.Thi

  12. Development of the Electrical Book

    OpenAIRE

    金澤, 邦生

    2012-01-01

    This research is inventing “Electrical Book” to argue about elements required for books after “Electronic Book” appearance. Electrical Book is the book made of printed circuit board printed text and illustration work as electronic circuit. We can read it as book and use it as electronic device. Today appearance of Electronic Book is changing the concept of book. We need make new model for book as media and goods. I study book design in this university so I try tackle this subject by making El...

  13. Silent screen: book review.

    OpenAIRE

    Ó Drisceoil, Donal

    2007-01-01

    Book Review. Kevin Rockett, Irish film censorship: a cultural journey from silent cinema to internet pornography (Dublin, 2004) and Mary Corcoran and Mark O'Brien (eds), Political censorship and the democratic state: the Irish broadcasting ban (Dublin, 2005)

  14. Climate Record Books

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Climate Record Books contain daily, monthly, seasonal, and annual averages, extremes, or occurrences. Most data are sequential by period of record 1871-1910,...

  15. Best Books of 1971

    Science.gov (United States)

    Gerhardt, Lillian N.; And Others

    1971-01-01

    The forty-two titles selected by the editors of School Library Journal" are the best among over 2,100 new children's books reviewed since last January. Also included are 25 top notch Young Adult titles. (67 references) (MM)

  16. The book house

    DEFF Research Database (Denmark)

    Jensen, Niels Henrik; Agger, Steen

    1989-01-01

    The BOOK HOUSE (and its predecessor, the BOOK AUTOMAT) are computer systems aimed at supporting library users in finding fiction. They are examples of systems using a cognitive work analysis as the basis for design and evaluation - and build on studies of the information retrieval task using actual...... user-librarian negotiations. These studies led to the identification of a set of strategies for searching and retrieving literature as well as a mutri-kimensional framework for classifying fiction. Both of these have been necessary prerequisites for the design of the BOOK HOUSE, a flexible on-line data...... base retrieval system for novice users - both adults and children. The use of icons within a spatial metaphor to facilitate direct manipulation of the displayed objects on the screen forms the basis for the interface in guiding the users' navigation in the BOOK HOUSE. This report, one of three...

  17. Recensione / Recension / Book review

    Directory of Open Access Journals (Sweden)

    Bravo Fabio

    2010-03-01

    Full Text Available Book review of:Sette R., Cases on Technologies for Teaching Criminology and Victimology: Methodologies and practices, IGI Global – Information Science Reference, Hershey PA, 2010

  18. Smart Book Charts

    Science.gov (United States)

    Chinnapongse, Ronald L.

    2015-01-01

    Smart book charts for TPSM: Heatshield for Extreme Entry Environment Technology (HEEET), Conformal Ablative TPS (CA-TPS), 3D Woven Multifunctional Ablative TPS (3D MAT), and Adaptable, Deployable, Entry and Placement Technology (ADEPT).

  19. New Fashioned Book Burning.

    Science.gov (United States)

    Gardner, Robert

    1997-01-01

    Reports on results of a teacher's experiment in book burning as a lesson accompanying the teaching of Ray Bradbury's "Fahrenheit 451." Discusses student reactions and the purpose of or justification for the experimental lesson. (TB)

  20. Book Reviews 2015

    Directory of Open Access Journals (Sweden)

    Hilling Axel

    2015-12-01

    Full Text Available This section contains three book reviews. First the book Swedish Taxation, Development since 1862 is reviewed. This volume comprises six studies that examine the development of Swedish taxation from 1862 to 2013, and will likely be of great value in future Nordic tax research because of its comprehensiveness. The second review is about a book written in Swedish:Momsfri sjukvård (The VAT exemption for health care. This volume discusses a topical issue and presents convincing recommendations for changes in the Swedish VAT legislation. Finally, the Danish book International Skatteret, i et dansk perspektiv (International Tax Law, in a Danish perspective is presented as highly recommended literature for students and practitioners in the field of international tax law. This volume discusses and illustrates general matters in international tax law, as well as specific matters relevant for Danish international tax law.

  1. Batik to Book

    Science.gov (United States)

    Tisinger, Betty

    1972-01-01

    Article describes how fifth- and sixth-graders first wrote Japanese Haiku poetry, then made books with batik covers. Materials needed and technique to follow are outlined, with photographs showing some details. (PD)

  2. AMAS Robotics Seminar Brief

    Science.gov (United States)

    2011-07-19

    Unclassified Unclassified 19 July 2011 AMAS ROBOTICS SEMINAR BRIEF Aaron Hart, Product Integrator, RS JPO DISTRIBUTION STATEMENT A. Approved for...19-07-2011 to 19-07-2011 4. TITLE AND SUBTITLE robotics seminar brief 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6...12. DISTRIBUTION/AVAILABILITY STATEMENT Approved for public release; distribution unlimited 13. SUPPLEMENTARY NOTES AMAS ROBOTICS SEMINAR BRIEF 14

  3. New Economics Books

    OpenAIRE

    Economics Library, Journal of

    2016-01-01

    A wide ranged Editor Selection of economic books published within the last 3 months by the publishers (for now; Cambridge University Press, Edward Elgar, Elsevier, MIT Press, Palgrave MacMillan, Springer, Wiley, and World Scientific) which are reached out “the consensus of no copyright infringement exists” could be found under this title. Afterwards, JEL will continue to publish the economic books published within the last 3 months as listing them in its quarter edition. This is expected to e...

  4. Books 'n' stuff

    DEFF Research Database (Denmark)

    Christoffersen, Ellen

    2007-01-01

    The book "Kommunikations-Controlling" by Manfred Piwinger/Viktor Porák (eds.) is an interim report in which several authors analyse the state of the art in the discussion of communications controlling.......The book "Kommunikations-Controlling" by Manfred Piwinger/Viktor Porák (eds.) is an interim report in which several authors analyse the state of the art in the discussion of communications controlling....

  5. Electronics engineer's reference book

    CERN Document Server

    Turner, L W

    1976-01-01

    Electronics Engineer's Reference Book, 4th Edition is a reference book for electronic engineers that reviews the knowledge and techniques in electronics engineering and covers topics ranging from basics to materials and components, devices, circuits, measurements, and applications. This edition is comprised of 27 chapters; the first of which presents general information on electronics engineering, including terminology, mathematical equations, mathematical signs and symbols, and Greek alphabet and symbols. Attention then turns to the history of electronics; electromagnetic and nuclear radiatio

  6. Enticing Spanish-Speaking Adolescents: Recent Books in Spanish for Every Taste/Cautivar a los Adolescentes Hispanohablantes: Libros Recientes en Espanol Para Todos los Gustos.

    Science.gov (United States)

    Schon, Isabel

    1999-01-01

    Argues that books in Spanish can engage Spanish-speaking students in the reading process, and that fostering the love of reading is a necessary first step to reading proficiency in any language. Offers brief descriptions of 16 recently published books in Spanish, and describes a large database of recommended books for children and adolescents in…

  7. Enticing Spanish-Speaking Adolescents: Recent Books in Spanish for Every Taste/Cautivar a los Adolescentes Hispanohablantes: Libros Recientes en Espanol Para Todos los Gustos.

    Science.gov (United States)

    Schon, Isabel

    1999-01-01

    Argues that books in Spanish can engage Spanish-speaking students in the reading process, and that fostering the love of reading is a necessary first step to reading proficiency in any language. Offers brief descriptions of 16 recently published books in Spanish, and describes a large database of recommended books for children and adolescents in…

  8. Book Review: Stop, Write!

    Directory of Open Access Journals (Sweden)

    Hans Thulesius

    2013-06-01

    Full Text Available This book on writing grounded theory is intended for the empirical GT researcher who wants to pursue his/her research until publication. It is the first book devoted entirely to such a crucial issue as writing grounded theory. Thus, Stop, Write: Writing Grounded Theory, is a practical book that fills a gap in GT methodology. In the first chapter of the book, Dr. Glaser says, “Stop unending conceptualization, unending data coverage, and unending listening to others who would egg you on with additional data, ideas and/or requirements or simply wait too long”. The book teaches the reader how to actually write a grounded theory by “simply” writing up the sorted memos. This requires efficient sorting that is dealt with in chapter two on Sorting Memos, which includes precious repetition from Theoretical Sensitivity (1978. How writing can be done effectively is outlined in chapter three The Working Paper. Then follows chapter four on how to rework the first draft with the different tasks of editing for language and professionalism. Thereafter Dr. Glaser discusses Writing Problems in chapter five where he gives useful guidance on how to overcome writing blocks and problems with supervisors and dissertation committees. The book also deals with publishing and with collaboration as experienced between Barney Glaser and the cofounder of grounded theory, Anselm Strauss.

  9. BOOK REVIEW: The Wandering Astronomer

    Science.gov (United States)

    Swinbank, Elizabeth

    2000-09-01

    Fans of Patrick Moore will like this book. I enjoyed it more than I expected, having anticipated a collection of personal anecdotes of the type favoured by certain tedious after-dinner speakers. Some of the 41 short items it contains do tend towards that category, but there are also some nuggets which might enliven your physics teaching. For example, did you know that, in a murder trial in 1787, the defendant's belief that the Sun was inhabited was cited as evidence of his insanity? This was despite his views being shared by many astronomers of the day including William Herschel. Or that Clyde Tombaugh had a cat called Pluto after the planet he discovered, which was itself named by an eleven-year-old girl? Another gem concerns a brief flurry, in the early 1990s, over a suspected planet orbiting a pulsar; variations in the arrival time of its radio pulses indicated the presence of an orbiting body. These shifts were later found to arise from an error in a computer program that corrected for the Earth's motion. The programmer had assumed a circular orbit for the Earth whereas it is actually elliptical. The book is clearly intended for amateur astronomers and followers of Patrick Moore's TV programmes. There is plenty of astronomy, with an emphasis on the solar system, but very little astrophysics. The author's metricophobia means that quantities are given in imperial units throughout, with metric equivalents added in brackets (by an editor, I suspect) which can get irritating, particularly as powers-of-ten notation is avoided. It is quite a novelty to see the temperature for hydrogen fusion quoted as 18 000 000 °F (10 000 000 °C). By way of contrast, astronomical terms are used freely - ecliptic, first-magnitude star, and so on. Such terms are defined in a glossary at the end, but attention is not drawn to this and I only stumbled across it by chance. Patrick Moore obviously knows his public, and this book will serve them well. For physics teachers and students

  10. SVD identifies transcript length distribution functions from DNA microarray data and reveals evolutionary forces globally affecting GBM metabolism.

    Science.gov (United States)

    Bertagnolli, Nicolas M; Drake, Justin A; Tennessen, Jason M; Alter, Orly

    2013-01-01

    To search for evolutionary forces that might act upon transcript length, we use the singular value decomposition (SVD) to identify the length distribution functions of sets and subsets of human and yeast transcripts from profiles of mRNA abundance levels across gel electrophoresis migration distances that were previously measured by DNA microarrays. We show that the SVD identifies the transcript length distribution functions as "asymmetric generalized coherent states" from the DNA microarray data and with no a-priori assumptions. Comparing subsets of human and yeast transcripts of the same gene ontology annotations, we find that in both disparate eukaryotes, transcripts involved in protein synthesis or mitochondrial metabolism are significantly shorter than typical, and in particular, significantly shorter than those involved in glucose metabolism. Comparing the subsets of human transcripts that are overexpressed in glioblastoma multiforme (GBM) or normal brain tissue samples from The Cancer Genome Atlas, we find that GBM maintains normal brain overexpression of significantly short transcripts, enriched in transcripts that are involved in protein synthesis or mitochondrial metabolism, but suppresses normal overexpression of significantly longer transcripts, enriched in transcripts that are involved in glucose metabolism and brain activity. These global relations among transcript length, cellular metabolism and tumor development suggest a previously unrecognized physical mode for tumor and normal cells to differentially regulate metabolism in a transcript length-dependent manner. The identified distribution functions support a previous hypothesis from mathematical modeling of evolutionary forces that act upon transcript length in the manner of the restoring force of the harmonic oscillator.

  11. Gravitational-wave Observations May Constrain Gamma-Ray Burst Models: The Case of GW150914-GBM

    Science.gov (United States)

    Veres, P.; Preece, R. D.; Goldstein, A.; Mészáros, P.; Burns, E.; Connaughton, V.

    2016-08-01

    The possible short gamma-ray burst (GRB) observed by Fermi/GBM in coincidence with the first gravitational-wave (GW) detection offers new ways to test GRB prompt emission models. GW observations provide previously inaccessible physical parameters for the black hole central engine such as its horizon radius and rotation parameter. Using a minimum jet launching radius from the Advanced LIGO measurement of GW 150914, we calculate photospheric and internal shock models and find that they are marginally inconsistent with the GBM data, but cannot be definitely ruled out. Dissipative photosphere models, however, have no problem explaining the observations. Based on the peak energy and the observed flux, we find that the external shock model gives a natural explanation, suggesting a low interstellar density (˜10-3 cm-3) and a high Lorentz factor (˜2000). We only speculate on the exact nature of the system producing the gamma-rays, and study the parameter space of a generic Blandford-Znajek model. If future joint observations confirm the GW-short-GRB association we can provide similar but more detailed tests for prompt emission models.

  12. THREE YEARS OF FERMI GBM EARTH OCCULTATION MONITORING: OBSERVATIONS OF HARD X-RAY/SOFT GAMMA-RAY SOURCES

    Energy Technology Data Exchange (ETDEWEB)

    Wilson-Hodge, Colleen A.; Jenke, Peter [ZP 12 Astrophysics Office, NASA Marshall Space Flight Center, Huntsville, AL 35812 (United States); Case, Gary L.; Cherry, Michael L.; Rodi, James [Department of Physics and Astronomy, Louisiana State University, Baton Rouge, LA 70803 (United States); Camero-Arranz, Ascension [Instituto de Ciencias del Espacio (IEEC-CSIC), Campus UAB, Torre C5, 2a planta, 08193 Barcelona (Spain); Chaplin, Vandiver; Bhat, Narayan; Briggs, Michael S.; Connaughton, Valerie; Preece, Robert [Physics Department, University of Alabama in Huntsville, Huntsville, AL 35899 (United States); Beklen, Elif [Physics Department, Suleyman Demirel University, 32260 Isparta (Turkey); Finger, Mark; Paciesas, William S. [Universities Space Research Association, Huntsville, AL 35805 (United States); Greiner, Jochen; Meegan, Charles A.; Von Kienlin, Andreas [Max-Planck Institut fuer Extraterrestische Physik, D-85748 Garching (Germany); Kippen, R. Marc [Los Alamos National Laboratory, Los Alamos, NM 87545 (United States)

    2012-08-01

    The Gamma-ray Burst Monitor (GBM) on board Fermi has been providing continuous data to the astronomical community since 2008 August 12. In this paper, we present the results of the analysis of the first three years of these continuous data using the Earth occultation technique to monitor a catalog of 209 sources. From this catalog, we detect 99 sources, including 40 low-mass X-ray binary/neutron star systems, 31 high-mass X-ray binary/neutron star systems, 12 black hole binaries, 12 active galaxies, and 2 other sources, plus the Crab Nebula, and the Sun. Nine of these sources are detected in the 100-300 keV band, including seven black hole binaries, the active galaxy Cen A, and the Crab. The Crab and Cyg X-1 are also detected in the 300-500 keV band. GBM provides complementary data to other sky-monitors below 100 keV and is the only all-sky monitor above 100 keV. Up-to-date light curves for all of the catalog sources can be found online.

  13. Three years of Fermi GBM Earth Occultation Monitoring: Observations of Hard X-ray/Soft Gamma-Ray Sources

    CERN Document Server

    Jenke, P; Case, Gary L; Cherry, Michael L; Rodi, James; Camero-Arranz, Ascension; Chaplin, Vandiver; Beklen, Elif; Finger, Mark H; Bhat, Narayana; Briggs, Michael S; Connaughto, Valerie; Greiner, Jochen; Kippen, R Marc; Meegan, Charles A; Paciesas, William S; Preece, Robert; von Kienlin, Andreas

    2013-01-01

    The Gamma ray Burst Monitor (GBM) on board Fermi Gamma-ray Space Telescope has been providing continuous data to the astronomical community since 2008 August 12. We will present the results of the analysis of the first three years of these continuous data using the Earth occultation technique to monitor a catalog of 209 sources. Although the occultation technique is in principle quite simple, in practice there are many complications including the dynamic instrument response, source confusion, and scattering in the Earth's atmosphere, which will be described. We detect 99 sources, including 40 low-mass X-ray binary/neutron star systems, 31 high-mass X-ray binary/neutron star systems, 12 black hole binaries, 12 active galaxies, 2 other sources, plus the Crab Nebula and the Sun. Nine of these sources are detected in the 100-300 keV band, including seven black-hole binaries, the active galaxy Cen A, and the Crab. The Crab and Cyg X-1 are also detected in the 300-500 keV band. GBM provides complementary data to ot...

  14. Kepler K2 Observations of Sco X-1: Orbital Modulations and Correlations with Fermi GBM and MAXI

    CERN Document Server

    Hynes, R I; Baum, Z A; Hsu, C -C; Cherry, M L; Scaringi, S

    2016-01-01

    We present a multi-wavelength study of the low-mass X-ray binary Sco X-1 using Kepler K2 optical data and Fermi GBM and MAXI X-ray data. We recover a clear sinusoidal orbital modulation from the Kepler data. Optical fluxes are distributed bimodally around the mean orbital light curve, with both high and low states showing the same modulation. The high state is broadly consistent with the flaring branch of the Z diagram and the low state with the normal branch. We see both rapid optical flares and slower dips in the high state, and slow brightenings in the low state. High state flares exhibit a narrow range of amplitudes with a striking cut-off at a maximum amplitude. Optical fluxes correlate with X-ray fluxes in the high state, but in the low state they are anti-correlated. These patterns can be seen clearly in both flux-flux diagrams and cross-correlation functions and are consistent between MAXI and GBM. The high state correlation arises promptly with at most a few minutes lag. We attribute this to thermal ...

  15. First Results from Fermi GBM Earth Occultation Monitoring: Observations of Soft Gamma-Ray Sources Above 100 keV

    CERN Document Server

    Case, Gary L; Rodi, James C; Jenke, Peter; Wilson-Hodge, Colleen A; Finger, Mark H; Meegan, Charles A; Camero-Arranz, Ascencion; Beklen, Elif; Bhat, P Narayan; Briggs, Michael S; Chaplin, Vandiver; Connaughton, Valerie; Paciesas, William S; Preece, Robert; Kippen, R Marc; von Kienlin, Andreas; Griener, Jochen

    2010-01-01

    The NaI and BGO detectors on the Gamma-ray Burst Monitor (GBM) on Fermi are now being used for long-term monitoring of the hard X-ray/low energy gamma-ray sky. Using the Earth occultation technique as demonstrated previously by the BATSE instrument on the Compton Gamma-Ray Observatory, GBM can be used to produce multiband light curves and spectra for known sources and transient outbursts in the 8 keV to 1 MeV energy range with its NaI detectors and up to 40 MeV with its BGO detectors. Over 85% of the sky is viewed every orbit, and the precession of the Fermi orbit allows the entire sky to be viewed every ~26 days with sensitivity exceeding that of BATSE at energies below ~25 keV and above ~1.5 MeV. We briefly describe the technique and present preliminary results using the NaI detectors after the first two years of observations at energies above 100 keV. Eight sources are detected with a significance greater than 7 sigma: the Crab, Cyg X-1, SWIFT J1753.5-0127, 1E 1740-29, Cen A, GRS 1915+105, and the transien...

  16. Is surgical spinal decompression for supratentorial GBM symptomatic drop down metastasis warranted? A case report and review of literature

    Directory of Open Access Journals (Sweden)

    Muhammad Babar Khan

    2014-01-01

    Full Text Available Background: Symptomatic spinal metastasis from an intracranial primary glioblastoma multiforme (GBM is very rare. Our literature search identified a total of 42 such patients of which 11 were treated with surgical decompression for spinal metastasis with only one such report from the pediatric age group. Previous studies have reported variable outcomes after surgical management. Case Description: We report the case of a 16-year-old boy who underwent surgical spinal decompression for spinal metastasis after intracranial GBM. The patient regained motor and autonomic function following surgery and reported improvement in pain. We also present findings from a literature review using the PubMed database from 1985 to June 2013 on this subject and compare radiation therapy with surgical decompression as palliative modalities in such patients. Conclusion: There are no evidence-based guidelines available on the subject and no treatment regimen has yet demonstrated survival benefit in these patients. Surgical decompression may be a better option for patients with focal resectable lesions and who are medically stable to tolerate the procedure.

  17. BOOK REVIEW: Nonlinear Magnetohydrodynamics

    Science.gov (United States)

    Shafranov, V.

    1998-08-01

    equations of a plasma in a magnetic field (which will be used further in models of dynamic processes), approaches to the description of three dimensional (3-D) equilibrium are briefly discussed, and the basis of the theory of linear instabilities and the basic types of MHD instabilities, with account taken of ideal resistive modes, are considered. The value of the material of these chapters is that here in a brief form the results of numerous researches in this area are presented, and frequently with a fresh point of view of old results. Chapters 5 to 10 are devoted to the subject of the book, non-linear magnetohydrodynamics. In the introduction to Chapter 5 the author pays attention to the fact that long standing doubts about the feasibility of magnetic thermonuclear reactors because of inevitable instabilities of non-uniform plasmas have been overcome in the last two decades: the plasma in tokamaks is rather well confined, despite the presence of some instabilities. The latter, as a rule, result only in the redistribution of current and plasma pressure profiles and some increase of transport, but can also lead to extremely undesirable effects. In this connection in Chapter 5 the attention of the reader is directed to the physics of the most important plasma instabilities in tokamaks. Models of the development of external and internal kink modes in tokamaks are considered, including the `vacuum bubble' model in shearless plasmas, the evolution of the resistive tearing mode together with saturation of the magnetic islands arising at a tearing instability. The rather long Chapter 6 is devoted to the fundamentals of the magnetic hydrodynamic dissipative process in the magnetic field line reconnection. This process of rapid dissipation of the energy of a magnetic field, having in the simplest case different directions in two adjacent volumes of plasma, underlies the theory of the phenomenon of powerful flares in the solar chromosphere, resulting in the well-known `magnetic

  18. Development and initial feedback about a human papillomavirus (HPV) vaccine comic book for adolescents.

    Science.gov (United States)

    Katz, Mira L; Oldach, Benjamin R; Goodwin, Jennifer; Reiter, Paul L; Ruffin, Mack T; Paskett, Electra D

    2014-06-01

    Human papillomavirus (HPV) vaccination rates do not meet the Healthy People 2020 objective of 80% coverage among adolescent females. We describe the development and initial feedback about an HPV vaccine comic book for young adolescents. The comic book is one component of a multilevel intervention to improve HPV vaccination rates among adolescents. Parents suggested and provided input into the development of a HPV vaccine comic book. Following the development of the comic book, we conducted a pilot study to obtain initial feedback about the comic book among parents (n = 20) and their adolescents ages 9 to 14 (n = 17) recruited from a community-based organization. Parents completed a pre-post test including items addressing HPV knowledge, HPV vaccine attitudes, and about the content of the comic book. Adolescents completed a brief interview after reading the comic book. After reading the comic book, HPV knowledge improved (2.7 to 4.6 correct answers on a 0-5 scale; p comic book's content was acceptable and adolescents liked the story, found it easy to read, and thought the comic book was a good way to learn about being healthy. Parents provided valuable information in the development of a theoretically-based comic book and the comic book appears to be an acceptable format for providing HPV vaccine information to adolescents. Future research will include the comic book in an intervention study to improve HPV vaccination rates.

  19. Seeing into Books: Lessons from Rare Book School

    Science.gov (United States)

    Hendrickson, Lois G.

    2012-01-01

    Recently, the author spent a week at Rare Book School (RBS) immersed in a course entitled "Teaching the History of the Book;" an investigation into different ways of thinking about, designing, and conducting a course on the history of the book. The goal was to learn how to convert teaching and outreach experiences in rare book collections from a…

  20. The Destruction of Books by Traditionists

    Directory of Open Access Journals (Sweden)

    Melchert, Christopher

    2014-06-01

    Full Text Available This paper is a survey of the destruction of books particularly by traditionists (collectors, transmitters, and critics of hadith and particularly in the ninth century CE and before, offered as an addendum to Omar Ali de Unzaga’s forthcoming study of book burning in Islam. The destruction of books from distrust of written transmission has been adequately brought out by Michael Cook. What I chiefly add to previous scholarly accounts are some additional examples, a brief consideration of destroying books for the sake of orthodoxy, and a better account of pious reasons for destroying books, which had much to do with distrust not of writing hadith but of teaching it as a temptation to pride and a distraction from weightier things.Este artículo ofrece una panorámica de la destrucción de libros especialmente por parte de los tradicionistas (compiladores, transmisores, críticos del hadiz, especialmente en el siglo IX de la era cristiana y antes, que sirve como una adenda al estudio (en curso de publicación de Omar Ali de Unzaga sobre la quema de libros en el islam. La destrucción de libros a causa de la desconfianza hacia la transmisión escrita ha sido analizada en profundidad por Michael Cook. Lo que me interesa añadir a la investigación previa son algunos ejemplos adicionales, unas breves consideraciones sobre la destrucción de libros en pro de la ortodoxia, y una mejor presentación de las razones piadosas para destruir libros, razones que tenían mucho que ver con la desconfianza no tanto de poner escrito el hadiz, sino de enseñarlo, en tanto que tentación para caer en la vanidad y distracción de asuntos más importantes.

  1. When Do Children Read Books?

    Science.gov (United States)

    van Ours, Jan C.

    2008-01-01

    This paper investigates the reading of fiction books by 15 year olds in 18 OECD countries. It appears that girls read fiction books more often than boys, whereas boys read comic books more often than girls. Parental education, family structure, and the number of books and televisions at home influence the intensity with which children read fiction…

  2. Mississippi: State Policy Brief

    Science.gov (United States)

    Corbett, Julie

    2014-01-01

    This brief is one in a series highlighting state policies, regulations, practices, laws, or other tools intended to create the necessary conditions for school and/or district turnaround. Each brief includes an overview of the relevant turnaround tool, its development process, its impact, and lessons learned that could assist other education…

  3. Florida: State Policy Brief

    Science.gov (United States)

    Corbett, Julie

    2015-01-01

    This brief is one in a series highlighting state policies, regulations, practices, laws, or other tools intended to create the necessary conditions for school and/or district turnaround. Each brief includes an overview of the relevant turnaround tool, its development process, its impact, and lessons learned that could assist other education…

  4. ENGLISH BOOK CLUB

    CERN Multimedia

    English Book Club

    2009-01-01

    http://club-englishbookclub.web.cern.ch A note to our members Dear Members, Many thanks to all of you who have paid up now. However, there are still some late payers and Morna would appreciate knowing if they will pay for 2009/2010 or if they have left the club. At the AGM on 17 November it was decided that a 3 month delay for key reimbursement will be given to all present and past members, BUT after 31.3.2010 no reimbursement will be given out. We are in the process of making changes to the access to the club for paid-up, active members only. Some of you have told Morna you will pay on your next visit to CERN, that is ok but please try to do this by 15 December if possible. A new version of the club’s book data-base is available on the web: http://club-englishbookclub.web.cern.ch/club-englishbookclub/Export/index.html The English Book Club has a growing collection of over 4500 English language books, mostly general fiction with a sprinkling of nonfiction and children’s books. New books...

  5. Preliminary study of technical terminology for the retrieval of scientific book metadata records

    DEFF Research Database (Denmark)

    Larsen, Birger; Lioma, Christina; Frommholz, Ingo;

    2012-01-01

    Books only represented by brief metadata (book records) are particularly hard to retrieve. One way of improving their retrieval is by extracting retrieval enhancing features from them. This work focusses on scientific (physics) book records. We ask if their technical terminology can be used...... as a retrieval enhancing feature. A study of 18,443 book records shows a strong correlation between their technical terminology and their likelihood of relevance. Using this finding for retrieval yields >+5% precision and recall gains. © 2012 Authors....

  6. The Secret and Curious Histories of Wonder Woman & Wonder Woman, a multiple book review:

    OpenAIRE

    Reyns-Chikuma, Chris

    2016-01-01

    Any search for references on « Wonder Woman » would show hundreds of articles but only 3 or 4 « serious » books. After the brief, yet forerunning, references in Trina Robbins’s various books on Women and Comics, in 2000, Les Daniels, one of the greatest fans-specialists of comics, published Wonder Woman, the Complete History (San Francisco Chronicle Books). Although the text is interesting, Daniels’ book is first and foremost useful for its many gorgeous illustrations. The text is relatively ...

  7. The Secret and Curious Histories of Wonder Woman & Wonder Woman, a multiple book review:

    OpenAIRE

    Reyns-Chikuma, Chris

    2016-01-01

    Any search for references on « Wonder Woman » would show hundreds of articles but only 3 or 4 « serious » books. After the brief, yet forerunning, references in Trina Robbins’s various books on Women and Comics, in 2000, Les Daniels, one of the greatest fans-specialists of comics, published Wonder Woman, the Complete History (San Francisco Chronicle Books). Although the text is interesting, Daniels’ book is first and foremost useful for its many gorgeous illustrations. The text is relatively ...

  8. A brief history of mechanical engineering

    CERN Document Server

    Dixit, Uday Shanker; Davim, J Paulo

    2017-01-01

    What is mechanical engineering? What a mechanical engineering does? How did the mechanical engineering change through ages? What is the future of mechanical engineering? This book answers these questions in a lucid manner. It also provides a brief chronological history of landmark events and answers questions such as: When was steam engine invented? Where was first CNC machine developed? When did the era of additive manufacturing start? When did the marriage of mechanical and electronics give birth to discipline of mechatronics? This book informs and create interest on mechanical engineering in the general public and particular in students. It also helps to sensitize the engineering fraternity about the historical aspects of engineering. At the same time, it provides a common sense knowledge of mechanical engineering in a handy manner.

  9. Book reviews 2016

    Directory of Open Access Journals (Sweden)

    Hilling Axel

    2016-11-01

    Full Text Available This section contains reviews of two Swedish books on international taxation. First, the book Skatteavtal och generalklausuler, Ett komparativt perspektiv (Tax Agreements and General Anti-Avoidance Regulations, A Comparative Perspective is recommended for those who study and work with international tax law. The book analyses how tax treaties’ function to limit contracting states’ taxing powers relates to national GAARs. A comparative analysis is made between Sweden and Canada. In the second review, the doctoral dissertation EU-domstolens restirktionsprövning i mal om de grundläggande frihterna och direkta skatter (The EU Court of Justice’s examination of the restriction requirement in its direct tax case law is reviewed. The dissertation systemizes relevant CJEU’s case law and analyzes the Courts reasoning in deciding whether or not certain tax regulation is in conflict with EU fundamental freedoms.

  10. Interactive Sample Book (ISB)

    DEFF Research Database (Denmark)

    Heimdal, Elisabeth Jacobsen; Lenau, Torben Anker; Guglielmi, Michel

    2009-01-01

    involving designers and engineers. It is carried out by Elisabeth Heimdal as her Master thesis from Design & Innovation, The Technical University of Denmark. Collaboration partners are the design bureau Diffus, textile designer Priya Mani, master student in medialogy at AAU Marija Andonovska and DTU......, with the aim of exploring and communicating some of the possibilities within interactive textiles. The applications for interactive textiles range from medical applications to architecture, and from the fashion industry to costume design. In relation to the sample book, focus will be on texture, lightning...... and senses in relation to integrated decoration and function primarily to indoor applications. The result of the project will be a number of interactive textiles, to be gathered in an interactive sample book (ISB), in a similar way as the sample books of wallpapers one can take home from the shop and choose...

  11. Year book Australia 1986

    Energy Technology Data Exchange (ETDEWEB)

    Castles, I. (comp.)

    1986-01-01

    The Year Book is the principal reference work produced by the Central Office of the Australian Bureau of Statistics (ABS). It provides a comprehensive and detailed statistical review of all asepcts of the economy and social conditions of Australia. In addition, it contains descriptive matter dealing with Australia's history, geography, physiography, climate and meteorology, government, defence, international relations, culture and environment. The first Official Year Book was published early in 1908. This is the seventieth Year Book issued under the authority of the Commonwealth Government and follows a similar pattern to previous editions. However chapters have been revised and new material has been added. Most of the statistics contained in this volume relate to the years ended June or December 1984 to 1985. More detailed, and in most cases more recent, statistics are available in other ABS publications.

  12. Check Out These Books

    Science.gov (United States)

    Collins, Michelle (Editor); Mulenburg, Gerald

    2002-01-01

    The book entitled "Fusion Leadership: Unlocking the Subtle Forces that Change People and Organizations Richard L. Daft and Robert H. Lengel (1998) Berett-Koehler Publishers, Inc." was Reviewed by Dr. Michelle Collins, NASA Headquarters. If you've already read books on leadership and organizational change by authors such as Moshe Rubinstein and Iris Firstenberg, Peter Senge, Tom Peters, and Steven Covey, and you were thinking of rereading them, you don't have to do that now. Just read this book instead. It's a fusion of many of their same concepts presented from a different view. The book does not explore any particular subject in depth. Rather the authors "skim" many subjects and concepts, interlacing them to develop the concept of "Fusion Leadership". The fundamental concept of treating people as people rather than machines is the main theme. "Fusion Leadership" is the process of fusing people together by nurturing six "subtle" forces: mindfulness, courage, vision, heart, communication, and integrity. To do so, hierarchy is diminished and responsibility both for oneself as well as for the team is emphasized. There are a number of organizations and managers that will find such a change threatening. The concepts behind such a management style are straightforward and the benefits are intuitive once you've reflected on them; however, the obvious benefits of the behavioral change proposed in Fusion Leadership can be completely lost in a fear-based system. The concept of caring about people in one's organization was the common thread in Chris Turner's book All Hat, No Cattle (see book review, ASK 5). Much is being written about the re-humanizing of the workplace, but the basis of it is so common sense that one wonders what's taking so long for the workplace to change? Whether you're in a position to change your organization or simply your project team, you'll find the concepts in fusion leadership equally applicable.

  13. CMS Comic Book

    CERN Multimedia

    Gill, Karl Aaron

    2006-01-01

    Titled "CMS Particle Hunter," this colorful comic book style brochure explains to young budding scientists and science enthusiasts in colorful animation how the CMS detector was made, its main parts, and what scientists hope to find using this complex tool. Book invites young students to get involved in particle physics themselves to join the adventure. Written by Dave Barney and Aline Guevera. Layout and drawings by Eric Paiharey and Frederic Vignaux. Available in English, French, German, Italian, Spanish and Portuguese. Year Produced: 2006. Update: September 2013.

  14. Newnes electrical pocket book

    CERN Document Server

    Reeves, E A

    2013-01-01

    Newnes Electrical Pocket Book, Twenty-first Edition, provides engineers with convenient access to various facts, tables, and formulae relating to the particular branch of engineering being dealt with. In the case of electrical engineering, it is essential that the engineer have a clear understanding of the methods by which the various formulae are derived to ensure that any particular formulae is applicable to the conditions being considered. The first section of the Pocket Book is devoted to the theoretical groundwork upon which all the practical applications are based. This covers symbols,

  15. Chemistry WebBook

    Science.gov (United States)

    SRD 69 NIST Chemistry WebBook (Web, free access)   The NIST Chemistry WebBook contains: Thermochemical data for over 7000 organic and small inorganic compounds; thermochemistry data for over 8000 reactions; IR spectra for over 16,000 compounds; mass spectra for over 33,000 compounds; UV/Vis spectra for over 1600 compounds; electronic and vibrational spectra for over 5000 compounds; constants of diatomic molecules(spectroscopic data) for over 600 compounds; ion energetics data for over 16,000 compounds; thermophysical property data for 74 fluids.

  16. Newnes microprocessor pocket book

    CERN Document Server

    Money, Steve

    2014-01-01

    Newnes Microprocessor Pocket Book explains the basic hardware operation of a microprocessor and describes the actions of the various types of instruction that can be executed. A summary of the characteristics of many of the popular microprocessors is presented. Apart from the popular 8- and 16-bit microprocessors, some details are also given of the popular single chip microcomputers and of the reduced instruction set computer (RISC) type processors such as the Transputer, Novix FORTH processor, and Acorn ARM processor.Comprised of 15 chapters, this book discusses the principles involved in bot

  17. The MCAT Physics Book

    CERN Document Server

    Biehle, Garrett

    2012-01-01

    Comprehensive, Rigorous Prep for MCAT Physics. The MCAT Physics Book offers the most comprehensive and rigorous analysis of MCAT physics available. Including,. Features:. * 500 MCAT-style practice problems and detailed solutions to all problems. * 49 MCAT-style passages. Illustrations and tables are included wherever necessary to focus and clarify key ideas and concepts. Dr. Biehle's classic MCAT Physics Book presents a clear, insightful analysis of MCAT physics. His lively prose and subtle wit make this challenging topic more palatable. Dr. Biehle received his Ph.D. from Caltech (California I

  18. Electronics engineer's reference book

    CERN Document Server

    Mazda, F F

    1989-01-01

    Electronics Engineer's Reference Book, Sixth Edition is a five-part book that begins with a synopsis of mathematical and electrical techniques used in the analysis of electronic systems. Part II covers physical phenomena, such as electricity, light, and radiation, often met with in electronic systems. Part III contains chapters on basic electronic components and materials, the building blocks of any electronic design. Part IV highlights electronic circuit design and instrumentation. The last part shows the application areas of electronics such as radar and computers.

  19. Electronics pocket book

    CERN Document Server

    Parr, E A

    1981-01-01

    Electronics Pocket Book, Fourth Edition is a nonmathematical presentation of the many varied topics covered by electronics. The book tackles electron physics, electronic components (i.e. resistors, capacitors, and conductors), integrated circuits, and the principles of a.c. and d.c. amplifiers. The text also discusses oscillators, digital circuits, digital computers, and optoelectronics (i.e., sensors, emitters, and devices that utilize light). Communications (such as line and radio communications, transmitters, receivers, and digital techniques); the principles and examples of servosystems; a

  20. Mechanical engineer's reference book

    CERN Document Server

    Parrish, A

    1973-01-01

    Mechanical Engineer's Reference Book: 11th Edition presents a comprehensive examination of the use of Systéme International d' Unités (SI) metrication. It discusses the effectiveness of such a system when used in the field of engineering. It addresses the basic concepts involved in thermodynamics and heat transfer. Some of the topics covered in the book are the metallurgy of iron and steel; screw threads and fasteners; hole basis and shaft basis fits; an introduction to geometrical tolerancing; mechanical working of steel; high strength alloy steels; advantages of making components as castings

  1. Web designer's idea book

    CERN Document Server

    McNeil, Patrick

    2014-01-01

    Discover the latest trends in web design! Looking for inspiration for your latest web design project? Expert Patrick McNeil, author of the popular Web Designer's Idea Book series, is back with all new examples of today's best website design. Featuring more than 650 examples of the latest trends, this fourth volume of The Web Designer's Idea Book is overflowing with visual inspiration. Arranged categorically, this fully illustrated guide puts important topics like design styles, elements, themes and responsive design at your fingertips. This new volume also includes a detailed discussion o

  2. Electrical engineer's reference book

    CERN Document Server

    Jones, G R

    2013-01-01

    A long established reference book: radical revision for the fifteenth edition includes complete rearrangement to take in chapters on new topics and regroup the subjects covered for easy access to information.The Electrical Engineer's Reference Book, first published in 1945, maintains its original aims: to reflect the state of the art in electrical science and technology and cater for the needs of practising engineers. Most chapters have been revised and many augmented so as to deal properly with both fundamental developments and new technology and applications that have come to the fore since

  3. Book advertisements in Osijek’s 19th century newspapers

    Directory of Open Access Journals (Sweden)

    Maja Krtalić

    2009-04-01

    Full Text Available The paper investigates the promotion of books through advertising in the newspapers published in Osijek in the second half of the 19th century. From late 18th century and in the course of the 19th century’s intense developments in the publishing of newspapers and journals, advertising in this medium was one of the ways to promote books. Booksellers and publishers advertised books in newspaper ads, relying on the fact that newspapers had become a common and omnipresent medium for disseminating information. Book advertisements were evidence of the position of books in relation to other aspects of culture and society, of the approach to their promotion and, finally, of the importance of book promotion. In order to investigate how and how much book ads were present, and how Croatian books were promoted and reached the readership, the paper analyses daily and monthly publications, such as Esseker allgemeine illustrierte Zeitung from 1869, Die Drau from 1968 to 1877, and Branislav from 1878. Among the eleven different papers published in the second half of the 19th century in Osijek, these were selected for their content, as they were the first illustrated newspapers (Esseker allgemeine illustrierte Zeitung. The investigation focused on the influence of the newly emerged illustrated press and on the influence of the newspapers published in Croatian language (Branislav, as a possible tool for spreading and promotion of Croatian books. Another focus was on the influence of continued publication and on the growth of a steady readership (Die Drau. The papers were analysed with the aim to locate book advertisements which were then subjected to content analysis. Also provided is a brief overview of the book production and publication in Croatia and in Osijek at the time, and an overview of the emergence of newspapers in Osijek with a brief account of the titles selected for study in order to gain an insight into the context in which book ads appeared. It

  4. Mindfulness meditation improves cognition: evidence of brief mental training.

    Science.gov (United States)

    Zeidan, Fadel; Johnson, Susan K; Diamond, Bruce J; David, Zhanna; Goolkasian, Paula

    2010-06-01

    Although research has found that long-term mindfulness meditation practice promotes executive functioning and the ability to sustain attention, the effects of brief mindfulness meditation training have not been fully explored. We examined whether brief meditation training affects cognition and mood when compared to an active control group. After four sessions of either meditation training or listening to a recorded book, participants with no prior meditation experience were assessed with measures of mood, verbal fluency, visual coding, and working memory. Both interventions were effective at improving mood but only brief meditation training reduced fatigue, anxiety, and increased mindfulness. Moreover, brief mindfulness training significantly improved visuo-spatial processing, working memory, and executive functioning. Our findings suggest that 4days of meditation training can enhance the ability to sustain attention; benefits that have previously been reported with long-term meditators.

  5. Development and pilot of a low-literacy diabetes education book using social marketing techniques.

    Science.gov (United States)

    Kavin, Michelle; Añel-Tiangco, Raquel M; Mauger, David T; Gabbay, Robert A

    2010-12-01

    The primary objective of this work was to develop a diabetes education book, to pilot its use, and to evaluate its impact on patient care. The secondary objective was to compare the value of providing only the book to patients versus providing the book along with a brief tutorial given by a nurse on how to use the book. A diabetes education book was developed through a social marketing approach. The impact of the book was then tested in a pilot, prospective, randomized controlled trial evaluating diabetes knowledge, emotional distress, self-care behavior, and clinical outcomes in a primary care patient population. The three-arm study randomized one group to usual care (n=33), one group to receive the book alone (n=33), and one group to receive the book with a brief nurse tutorial (n=34). Patients completed surveys at baseline, 4 weeks, 3 months, and 6 months to assess knowledge (Knowledge Questionnaire), self-care behaviors (Summary of Diabetes Self Care Activities [SDSCA] survey), and disease-related distress (Problem Areas in Diabetes [PAID] scale). A patient advocacy committee identified a need for information on basic diabetes knowledge, diet, medications, complications, preparing for a visit, and plans for daily life. Using social marketing with a focus on low literacy, the Penn State Hershey Diabetes Playbook was created. The pilot study showed a trend towards improved knowledge, decreased distress, and improved self-care behaviors in patients who received the book. There was no difference in outcomes in patients who were provided the book alone versus those who received a brief nurse tutorial along with the book. Social marketing techniques and low literacy awareness are useful in developing diabetes educational materials.

  6. Book review: ALMOG, J. Referential Mechanics: Direct Reference and the Foundations of Semantics (Oxford University Press, 2014

    Directory of Open Access Journals (Sweden)

    Filipe Martone

    Full Text Available Abstract: In this review I discuss Joseph Almog's book "Referential Mechanics". The book discusses direct reference as conceived by three of its founding fathers, Kripke, Kaplan and Donnellan, and introduces Almog's ambitious project of providing a referential semantics to all subject-phrases. I offer a brief overview of its four chapters and point out some of their virtues and shortcomings.

  7. VizieR Online Data Catalog: IPN supplement to the 2nd Fermi GBM catalog (Hurley+, 2017)

    Science.gov (United States)

    Hurley, K.; Aptekar, R. L.; Golenetskii, S. V.; Frederiks, D. D.; Svinkin, D. S.; Pal'Shin, V. D.; Briggs, M. S.; Meegan, C.; Connaughton, V.; Goldsten, J.; Boynton, W.; Fellows, C.; Harshman, K.; Mitrofanov, I. G.; Golovin, D. V.; Kozyrev, A. S.; Litvak, M. L.; Sanin, A. B.; Rau, A.; von Kienlin, A.; Zhang, X.; Yamaoka, K.; Fukazawa, Y.; Ohno, M.; Tashiro, M.; Terada, Y.; Barthelmy, S.; Cline, T.; Gehrels, N.; Cummings, J.; Krimm, H. A.; Smith, D. M.; Del, Monte E.; Feroci, M.; Marisaldi, M.

    2017-06-01

    The triangulation technique utilized for the present catalog is identical to that used for the first IPN/GBM catalog; the details may be found in Hurley+ (2013, J/ApJS/207/39). Also, the missions and experiments comprising the InterPlanetary Network (IPN) are the same. The IPN consisted of Konus-Wind, at up to approximately 5light-seconds from Earth; Mars Odyssey, in orbit around Mars at up to 1250light-seconds from Earth; the International Gamma-Ray Laboratory (INTEGRAL), in an eccentric Earth orbit at up to 0.5light-seconds from Earth; Mercury Surface, Space Environment, Geochemistry, and Ranging mission (MESSENGER), in an eccentric orbit around Mercury beginning 2011 March 18, up to 690 light-seconds from Earth; and Ramaty High Energy Solar Spectroscopic Imager (RHESSI), Swift, Fermi, Suzaku, and AGILE, all in low-Earth orbit. (3 data files).

  8. Relationship of pre-surgery metabolic and physiological MR imaging parameters to survival for patients with untreated GBM

    Science.gov (United States)

    Crawford, Forrest W.; Khayal, Inas S.; McGue, Colleen; Saraswathy, Suja; Pirzkall, Andrea; Cha, Soonmee; Lamborn, Kathleen R.; Chang, Susan M.; Berger, Mitchel S.

    2010-01-01

    Glioblastoma Multiforme (GBM) are heterogeneous lesions, both in terms of their appearance on anatomic images and their response to therapy. The goal of this study was to evaluate the prognostic value of parameters derived from physiological and metabolic images of these lesions. Fifty-six patients with GBM were scanned immediately before surgical resection using conventional anatomical MR imaging and, where possible, perfusion-weighted imaging, diffusion-weighted imaging, and proton MR spectroscopic imaging. The median survival time was 517 days, with 15 patients censored. Absolute anatomic lesion volumes were not associated with survival but patients for whom the combined volume of contrast enhancement and necrosis was a large percentage of the T2 hyperintense lesion had relatively poor survival. Other volumetric parameters linked with less favorable survival were the volume of the region with elevated choline to N-acetylaspartate index (CNI) and the volume within the T2 lesion that had apparent diffusion coefficient (ADC) less than 1.5 times that in white matter. Intensity parameters associated with survival were the maximum and the sum of levels of lactate and of lipid within the CNI lesion, as well as the magnitude of the 10th percentile of the normalized ADC within the contrast-enhancing lesion. Patients whose imaging parameters indicating that lesions with a relatively large percentage with breakdown of the blood brain barrier or necrosis, large regions with abnormal metabolism or areas with restricted diffusion have relatively poor survival. These parameters may provide useful information for predicting outcome and for the stratification of patients into high or low risk groups for clinical trials. PMID:19009235

  9. SVD identifies transcript length distribution functions from DNA microarray data and reveals evolutionary forces globally affecting GBM metabolism.

    Directory of Open Access Journals (Sweden)

    Nicolas M Bertagnolli

    Full Text Available To search for evolutionary forces that might act upon transcript length, we use the singular value decomposition (SVD to identify the length distribution functions of sets and subsets of human and yeast transcripts from profiles of mRNA abundance levels across gel electrophoresis migration distances that were previously measured by DNA microarrays. We show that the SVD identifies the transcript length distribution functions as "asymmetric generalized coherent states" from the DNA microarray data and with no a-priori assumptions. Comparing subsets of human and yeast transcripts of the same gene ontology annotations, we find that in both disparate eukaryotes, transcripts involved in protein synthesis or mitochondrial metabolism are significantly shorter than typical, and in particular, significantly shorter than those involved in glucose metabolism. Comparing the subsets of human transcripts that are overexpressed in glioblastoma multiforme (GBM or normal brain tissue samples from The Cancer Genome Atlas, we find that GBM maintains normal brain overexpression of significantly short transcripts, enriched in transcripts that are involved in protein synthesis or mitochondrial metabolism, but suppresses normal overexpression of significantly longer transcripts, enriched in transcripts that are involved in glucose metabolism and brain activity. These global relations among transcript length, cellular metabolism and tumor development suggest a previously unrecognized physical mode for tumor and normal cells to differentially regulate metabolism in a transcript length-dependent manner. The identified distribution functions support a previous hypothesis from mathematical modeling of evolutionary forces that act upon transcript length in the manner of the restoring force of the harmonic oscillator.

  10. The dosimetric impact of gadolinium-based contrast media in GBM brain patient plans for a MRI-Linac

    Science.gov (United States)

    Bilal Ahmad, Syed; Paudel, Moti Raj; Sarfehnia, Arman; Kim, Anthony; Pang, Geordi; Ruschin, Mark; Sahgal, Arjun; Keller, Brian M.

    2017-08-01

    Dosimetric effects of gadolinium based contrast media (Gadovist) were evaluated for the Elekta MRI linear accelerator using the research version of the Monaco treatment planning system (TPS). In order to represent a gadolinium uptake, the contrast was manually assigned to a phantom as well as to the gross tumour volume (GTV) of 6 glioblastoma multiforme (GBM) patients. A preliminary estimate of the dose enhancement, due to gadolinium, was performed using the phantom irradiated with a single beam. A more complicated assessment was performed for the GBM patients using a 7 field IMRT technique. The material table in Monaco was modified in order to identify the presence of a non-biological material. The dose distribution was modelled using GPUMCD (MC algorithm in Monaco) for an unmodified (or default) material table (DMT) as well as for a modified (or custom) material table (CMT) for both the phantom and patients. Various concentrations ranging between 8 and 157 mg ml-1 were used to represent the gadolinium uptake in the patient’s GTV. It was assumed that the gadolinium concentration remained the same for the entire course of radiation treatment. Results showed that at the tissue-Gadovist interface, inside the phantom, dose scored using the DMT was 7% lower compared to that using the CMT for 157 mg ml-1 concentration of gadolinium. Dosimetric differences in the case of the patient study were measured using the DVH parameters. D 50% was higher by 6% when the DMT was used compared to the CMT for dose modelling for a gadolinium concentration of 157 mg ml-1. This difference decreased gradually with decreasing concentration of gadolinium. It was concluded that dosimetric differences can be quantified in Monaco if the tumour-gadolinium concentration is more than 23 mg ml-1. If the gadolinium concentration is lower than 23 mg ml-1, then a correction for the presence of gadolinium may not be necessary in the TPS.

  11. Medical Physics Data Book,

    Science.gov (United States)

    The Medical Physics Data Book is a collection of physical and chemical data useful in medical physics . The information has been extracted from other...ionizing Radiation. Carried out by the Medical Physics Data Group of the American Association of Physicists in Medicine, this compilation is meant to

  12. The enemies of books

    CERN Document Server

    Blades, William

    2012-01-01

    A fascinating look at the myriad enemies of the printed book, from fire, to neglect, to children, to the bookworm, to plain old ignorance. A passionate litany against all who would see printed literature destroyed, written by English printer and bibliographer William Blades.

  13. Bridging Inequity With Books.

    Science.gov (United States)

    Krashen, Stephen

    1998-01-01

    Providing rich supply of high-interest story books is more feasible policy for literacy education than urgent exhortations to improve teacher quality. Free reading profoundly improves students' reading and writing ability, spelling, grammar, and vocabulary. The quality of a country s or state's school libraries significantly predicts its reading…

  14. CMS Comic Book Brochure

    CERN Document Server

    2006-01-01

    To raise students' awareness of what the CMS detector is, how it was constructed and what it hopes to find. Titled "CMS Particle Hunter," this colorful comic book style brochure explains to young budding scientists and science enthusiasts in colorful animation how the CMS detector was made, its main parts, and what scientists hope to find using this complex tool.

  15. The Comic Book Project

    Science.gov (United States)

    Bitz, Michael

    2008-01-01

    The Comic Book Project (CBP) celebrates its eighth anniversary this year. The project, which just originated with one school in New York City, had grown to encompass thousands of students nationwide. The goal of the CBP is not to create comics the "Marvel way" or to develop the next Stan Lee. Rather, the goal is to give students the opportunity to…

  16. The Comic Book Project

    Science.gov (United States)

    Bitz, Michael

    2008-01-01

    The Comic Book Project (CBP) celebrates its eighth anniversary this year. The project, which just originated with one school in New York City, had grown to encompass thousands of students nationwide. The goal of the CBP is not to create comics the "Marvel way" or to develop the next Stan Lee. Rather, the goal is to give students the opportunity to…

  17. China resource book

    NARCIS (Netherlands)

    Trouwborst, K.O.; Eijndthoven, van P.J.

    1999-01-01

    The China Resource Book explains the organisation of the agricultural production in China and relates it to China's efforts to eradicate poverty and achieve self-sufficiency in food. It also highlights the variety of environmental problems, which haverisen since the rapid industrial development in t

  18. Basic Drafting: Book Two.

    Science.gov (United States)

    Davis, Ronald; And Others

    The second of a two-book course in drafting, this manual consists of 12 topics in the following units: sketching techniques, geometric constructions, orthographic views, dimensioning procedures, basic tolerancing, auxiliary views, sectional views, inking tools and techniques, axonometrics, oblique, perspective, and computer-aided drafting.…

  19. Book on CPC Published

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    A book that answers 13 questions about how the Communist Party of China(CPC) works in China and why the Party has made great achievements in the past decades has been recently published by the Beijing-based New World Press.

  20. Best Books 2010

    Science.gov (United States)

    Jones, Trevelyn; Toth, Luann; Charnizon, Marlene; Grabarek, Daryl; Fleishhacker, Joy

    2010-01-01

    This article presents the 62 books chosen by "School Library Journal's" editors as the best of the year. While novels include some historical settings and contemporary concerns, it is fantasy that continues to reign supreme. More original, and more creative than ever, it includes selections that are frightening, edgy, wildly funny, electrifying,…

  1. Book Reviews/Boekbesprekings

    African Journals Online (AJOL)

    rarer types of neurological problems which the student or trainee is likely to encounter. ... The present book is a joint effort by teachers associated with. Baltimore City ..... English and German, and weighing over 3 kg, this is a mammoth compendium of ... The 12 chapters of volume 3 cover hearing disorders, several as pects ...

  2. Books/Boeke

    African Journals Online (AJOL)

    human placenta or strips of extra-ocular muscle to improve choroidal bloodflow ... current treatments. For registrars in training, the·book provides ..... for the inspiratory splirting of the pulmonary second sound ('hang out' effect) rather than being ...

  3. Books/Boeke

    African Journals Online (AJOL)

    as an updated introduction to political psychology and describes the growing interest ... the eyes of political adversaries. Arrention is drawn to .... this, and both criteria are measures of how up to date the book is. .... control regions. The structure ...

  4. Books for Summer Reading.

    Science.gov (United States)

    Phi Delta Kappan, 1995

    1995-01-01

    Recommends many books for summer reading enjoyment, concentrating on historical and contemporary fiction. Different cultures clash in William T. Vollman's "Fathers and Crows" and John Demos's adventuresome "Unredeemed Captive." Other suggestions: "Snow Falling on Cedar Mountain" (David Gutterman) and "Foxfire" (Joyce Carol Oates). For professional…

  5. Administration Trip Books

    Science.gov (United States)

    2007-11-02

    Plan. (h) Army Community of Excellence. (i) Child development services. k. The Assistant Secretary of the Army for Manpower and Reserve Affairs ( ASAM ...RA) will — (1) Provide information as requested when the information falls under the purview of the ASAM &RA. (2) Provide recurring trip book

  6. Hurrah for Chapter Books.

    Science.gov (United States)

    Jones, Glenowyn L.

    This annotated bibliography contains a list of 42 recent Chapter Books. The bibliography is divided into the following topics: Adventure-Survival (3 titles); Autobiography-Biography (3 titles); Death (1 title); Easy Readers (8 titles); Good Reading (12 titles); Historical Fiction (10 titles); Mystery (3 titles); Newbery Award Winner, 2000; and…

  7. Bonus Activity Book.

    Science.gov (United States)

    Learning, 1993

    1993-01-01

    Elementary level activity book presents suggestions for teaching students about endangered and threatened species worldwide. Students learn about what is causing the rapid extinction rate and what needs to be done. They also discover the value of rainforests and why conservationists are fighting to save them. (SM)

  8. On Japanese Children's Books.

    Science.gov (United States)

    Watanare, Shigeo

    This report, given at a special meeting held in Tehran, presents data and facts concerning yearly publications (books, magazines, and textbooks), translations, and illustrations of Japanese children's literature. The report then discusses at length recent trends in children's literature and library activities for children in the past, present, and…

  9. Books, Biodiversity, and Beyond!

    Science.gov (United States)

    Governor, Donna; Helms, Sarah

    2007-01-01

    Reading in science class does not have to be boring, but it is no secret to students or teachers that textbooks are not much fun to read. It is always a challenge for teachers to find reading materials that would grab the interests of their students. In this article, the author relates how she used Biodiversity, a nonfiction book by Dorothy…

  10. Boekbesprekinge/Book Reviews

    African Journals Online (AJOL)

    SA MEDICAL JOURNAL VOLUME 63 22 JANUARY 1983 ... Bone in clinical orthopaedics. Bone in Clinical Orthopaedics: A Study in Comparative. Osteology. ... This is oneof the more dramatic stories in the history of experimental mecticine, ... facsimile reproduction (misprints and all) of his 1833 book by. Gryphon Editions.

  11. Spoken Russian; Book Two.

    Science.gov (United States)

    Bloomfield, Leonard; Petrova, Luba

    This course in spoken Russian is intended for use in introductory conversational classes. Book II in the two volume series is divided into three major parts, each containing five learning units and one unit devoted to review. Each unit contains sections including (1) basic sentences, (2) word study and review of basic sentences, (3) listening…

  12. Book Catalog Use Study

    Science.gov (United States)

    Sacco, Concetta N.

    1973-01-01

    Technological developments of the past twenty years have resulted in renewed interest in book-form catalogs. Users were surveyed at two libraries to determine that their satisfaction with bibliographical data, entry points, and physical form. (17 references) (Author/DH)

  13. Best Books 2010

    Science.gov (United States)

    Jones, Trevelyn; Toth, Luann; Charnizon, Marlene; Grabarek, Daryl; Fleishhacker, Joy

    2010-01-01

    This article presents the 62 books chosen by "School Library Journal's" editors as the best of the year. While novels include some historical settings and contemporary concerns, it is fantasy that continues to reign supreme. More original, and more creative than ever, it includes selections that are frightening, edgy, wildly funny, electrifying,…

  14. Spoken Russian; Book Two.

    Science.gov (United States)

    Bloomfield, Leonard; Petrova, Luba

    This course in spoken Russian is intended for use in introductory conversational classes. Book II in the two volume series is divided into three major parts, each containing five learning units and one unit devoted to review. Each unit contains sections including (1) basic sentences, (2) word study and review of basic sentences, (3) listening…

  15. Bold Books for Teenagers

    Science.gov (United States)

    Gallo, Don

    2005-01-01

    "Bold Books for Teenagers" provides dynamic, informative viewpoints on important issues in publishing and teaching contemporary literature, especially literature for adolescents. Reviews of young adult literature also appear in this column. This article examines how English teachers can help students explore their interests without promoting any…

  16. Books for Summer Reading.

    Science.gov (United States)

    [Editors

    2001-01-01

    Teachers and education professors suggest various nonfiction and fiction books for summer reading enjoyment, from Robert Putnam's "Bowling Alone," C.A. Bowers's "Let Them Eat Data," and Larry McMurtry's "Roads: Driving America's Great Highways" to Kent Hauf's "Plainsong, J.M. Coetzee's "Disgrace," and Michael Cunningham's "The Hours." (MLH)

  17. Whole-book recognition.

    Science.gov (United States)

    Xiu, Pingping; Baird, Henry S

    2012-12-01

    Whole-book recognition is a document image analysis strategy that operates on the complete set of a book's page images using automatic adaptation to improve accuracy. We describe an algorithm which expects to be initialized with approximate iconic and linguistic models--derived from (generally errorful) OCR results and (generally imperfect) dictionaries--and then, guided entirely by evidence internal to the test set, corrects the models which, in turn, yields higher recognition accuracy. The iconic model describes image formation and determines the behavior of a character-image classifier, and the linguistic model describes word-occurrence probabilities. Our algorithm detects "disagreements" between these two models by measuring cross entropy between 1) the posterior probability distribution of character classes (the recognition results resulting from image classification alone) and 2) the posterior probability distribution of word classes (the recognition results from image classification combined with linguistic constraints). We show how disagreements can identify candidates for model corrections at both the character and word levels. Some model corrections will reduce the error rate over the whole book, and these can be identified by comparing model disagreements, summed across the whole book, before and after the correction is applied. Experiments on passages up to 180 pages long show that when a candidate model adaptation reduces whole-book disagreement, it is also likely to correct recognition errors. Also, the longer the passage operated on by the algorithm, the more reliable this adaptation policy becomes, and the lower the error rate achieved. The best results occur when both the iconic and linguistic models mutually correct one another. We have observed recognition error rates driven down by nearly an order of magnitude fully automatically without supervision (or indeed without any user intervention or interaction). Improvement is nearly monotonic, and

  18. Hedgehog signaling pathway is active in GBM with GLI1 mRNA expression showing a single continuous distribution rather than discrete high/low clusters.

    Directory of Open Access Journals (Sweden)

    Vikas Chandra

    Full Text Available Hedgehog (Hh signaling pathway is a valid therapeutic target in a wide range of malignancies. We focus here on glioblastoma multiforme (GBM, a lethal malignancy of the central nervous system (CNS. By analyzing RNA-sequencing based transcriptomics data on 149 clinical cases of TCGA-GBM database we show here a strong correlation (r = 0.7 between GLI1 and PTCH1 mRNA expression--as a hallmark of the canonical Hh-pathway activity in this malignancy. GLI1 mRNA expression varied in 3 orders of magnitude among the GBM patients of the same cohort showing a single continuous distribution-unlike the discrete high/low-GLI1 mRNA expressing clusters of medulloblastoma (MB. When compared with MB as a reference, the median GLI1 mRNA expression in GBM appeared 14.8 fold lower than that of the "high-Hh" cluster of MB but 5.6 fold higher than that of the "low-Hh" cluster of MB. Next, we demonstrated statistically significant up- and down-regulation of GLI1 mRNA expressions in GBM patient-derived low-passage neurospheres in vitro by sonic hedgehog ligand-enriched conditioned media (shh-CM and by Hh-inhibitor drug vismodegib respectively. We also showed clinically achievable dose (50 μM of vismodegib alone to be sufficient to induce apoptosis and cell cycle arrest in these low-passage GBM neurospheres in vitro. Vismodegib showed an effect on the neurospheres, both by down-regulating GLI1 mRNA expression and by inducing apoptosis/cell cycle arrest, irrespective of their relative endogenous levels of GLI1 mRNA expression. We conclude from our study that this single continuous distribution pattern of GLI1 mRNA expression technically puts almost all GBM patients in a single group rather than discrete high- or low-clusters in terms of Hh-pathway activity. That is suggestive of therapies with Hh-pathway inhibitor drugs in this malignancy without a need for further stratification of patients on the basis of relative levels of Hh-pathway activity among them.

  19. Book Review: 3 Titles from A Book Apart

    Directory of Open Access Journals (Sweden)

    Nathan Mealey

    2011-07-01

    Full Text Available Three recently published books by A Book Apart, the book-publishing arm of the website A List Apart, offer concise, high-impact introductions to three tools that can be employed in facing this challenge: HTML5, CSS3, and content strategy. This article reviews the books "HTML5 For Web Designers" by Jeremy Keith; "CSS3 for Web Designers" by Dan Cederholm; and "The Elements of Content Strategy" by Erin Kissane.

  20. BOOK REVIEW: Solid State Physics: An Introduction

    Science.gov (United States)

    Jakoby, Bernhard

    2009-07-01

    There's a wealth of excellent textbooks on solid state physics. The author of the present book is well aware of this fact and does not attempt to write just another one. Rather, he has provided a very compact introduction to solid state physics for third-year students. As we are faced with the continuous appearance interdisciplinary fields and associated study curricula in natural and engineering sciences (biophysics, mechatronics, etc), a compact text in solid state physics would be appreciated by students of these disciplines as well. The book features 11 chapters where each is provided with supplementary discussion questions and problems. The first chapters deal with a review of chemical bonding mechanisms, crystal structures and mechanical properties of solids, which are brief but by no means superficial. The following, somewhat more detailed chapter on thermal properties of lattices includes a nice introduction to phonons. The foundations of solid state electronics are treated in the next three chapters. Here the author first discusses the classical treatment of electronic behaviour in metals (Drude model) and continues with a quantum-theoretical approach starting with the free-electron model and leading to the band structures in conductive solids. The next chapter is devoted to semiconductors and ends with a brief but, with respect to the topical scope, adequate discussion of semiconductor devices. The classical topics of magnetic and dielectric behaviour are treated in the sequel. The book closes with a chapter on superconductivity and a brief chapter covering the modern topics of quantum confinement and aspects of nanoscale physics. In my opinion, the author has succeeded in creating a very concise yet not superficial textbook. The account presented often probes subjects deep enough to lay the basis for a thorough understanding, preparing the reader for more specialized textbooks. For instance, I think that this book may serve as an excellent first

  1. Analýza současné situace na trhu elektronických knih (e-book) v České republice

    OpenAIRE

    Kubeš, Adam

    2011-01-01

    The thesis "Analysis of the current situation on the market of electronic books (eBook) in the Czech Republic", deals with topics and issues of e-books and the current market situation in the Czech Republic. One of its objectives is to introduce readers to the world of e-books, show a brief history and development of books and e-books as a medium, getting to know what's happening in the U.S., and particularly on the Czech market. For this thesis, it was developed an online questionnaire "Elec...

  2. Analýza současné situace na trhu elektronických knih (e-book) v České republice

    OpenAIRE

    Kubeš, Adam

    2011-01-01

    The thesis "Analysis of the current situation on the market of electronic books (eBook) in the Czech Republic", deals with topics and issues of e-books and the current market situation in the Czech Republic. One of its objectives is to introduce readers to the world of e-books, show a brief history and development of books and e-books as a medium, getting to know what's happening in the U.S., and particularly on the Czech market. For this thesis, it was developed an online questionnaire "Elec...

  3. BOOK REVIEWS: Quantum Mechanics: Fundamentals

    Science.gov (United States)

    Whitaker, A.

    2004-02-01

    Scientific edition of Bell’s collected works. Thus it is exceedingly interesting to discover how he has responded to Bell’s criticisms in the new edition of the book. To commence with general discussion of the new book, the authors recognise that the graduate student of today almost certainly has substantial experience of wave mechanics, and is probably familiar with the Dirac formalism. The 1966 edition had what seems, at least in retrospect, a relatively soft opening covering the basic ideas of wave mechanics and a substantial number of applications; it did not reach the Dirac formalism in the first two hundred pages, though it then moved on to tackle rather advanced topics, including a very substantial section on symmetries, which tackled a range of sophisticated issues. The new edition has been almost entirely rewritten; even at the level of basic text, it is difficult to trace sentences or paragraphs that have moved unscathed from one edition to the next. As well as the new topics, many of the old ones are discussed in much greater depth, and the general organisation is entirely different. As compared with the steady rise in level of the 1966 edition, the level of this book is fairly consistent throughout, and from the perspective of a beginning graduate student, I would estimate, a little tough. A brief introductory chapter gives a useful, though not particularly straightforward, discussion of complementarity, uncertainty and superposition, and concludes with an informative though very short summary of the discovery of quantum mechanics, together with a few nice photographs of some of its founders. There follow two substantial chapters which are preparation for the later study of actual systems. The first, called ‘The Formal Framework’ is a fairly comprehensive survey of the methods of quantum theory---Hilbert space, Dirac notation, mixtures, the density matrix, entanglement, canonical quantization, equations of motion, symmetries, conservation laws

  4. The Burden of the Book

    DEFF Research Database (Denmark)

    Damkjær, Maria

    2012-01-01

    Review of Leah Price, How to Do Things with Books in Victorian Britain (Princeton University Press, 2012)......Review of Leah Price, How to Do Things with Books in Victorian Britain (Princeton University Press, 2012)...

  5. Exploring Cultural Diversity (Children's Books).

    Science.gov (United States)

    Galda, Lee; Cotter, Janet

    1992-01-01

    Reviews 57 children's books, combining realistic fiction, nonfiction, poetry, literary folklore, and folklore from people and places around the world, that reveal the cultural wonders of the world. Offers suggestions on how to group these books within thematic units. (MG)

  6. Moving from Books to Bytes.

    Science.gov (United States)

    Albanese, Andrew Richard

    2001-01-01

    This academic library book buying survey examines full-text databases; electronic journals; top circulating subjects; price increases for serials and resulting subscription cuts; the influence of digital choices on purchasing decisions; circulation versus use statistics; and electronic books. (LRW)

  7. Exploring Cultural Diversity (Children's Books).

    Science.gov (United States)

    Galda, Lee; Cotter, Janet

    1992-01-01

    Reviews 57 children's books, combining realistic fiction, nonfiction, poetry, literary folklore, and folklore from people and places around the world, that reveal the cultural wonders of the world. Offers suggestions on how to group these books within thematic units. (MG)

  8. TM4Book: Visualization transforms

    DEFF Research Database (Denmark)

    2011-01-01

    XSLT-scripts til visualisering af semantiske strukturer i teksteditoren TM4Book: plot, storyline og timeline......XSLT-scripts til visualisering af semantiske strukturer i teksteditoren TM4Book: plot, storyline og timeline...

  9. Best in show [artists' book

    OpenAIRE

    Wood, Philippa

    2011-01-01

    This limited edition artists' book explores the phenomenon of prize vegetable growing. Each replica seed packet is over-printed with data that relates to a current world record holder. Further facts appear on the back to help put the statistics into context. The book was produced for a 'call for entries' to submit books that responded to the theme of 'crop'. Concertina book – machine stitched. Printed inkjet, letterpress, typewriter.

  10. Engineering mathematics pocket book

    CERN Document Server

    Bird, John

    2008-01-01

    This compendium of essential formulae, definitions, tables and general information provides the mathematical information required by students, technicians, scientists and engineers in day-to-day engineering practice. A practical and versatile reference source, now in its fourth edition, the layout has been changed and the book has been streamlined to ensure the information is even more quickly and readily available - making it a handy companion on-site, in the office as well as for academic study. It also acts as a practical revision guide for those undertaking BTEC Nationals, Higher Nationals and NVQs, where engineering mathematics is an underpinning requirement of the course.All the essentials of engineering mathematics - from algebra, geometry and trigonometry to logic circuits, differential equations and probability - are covered, with clear and succinct explanations and illustrated with over 300 line drawings and 500 worked examples based in real-world application. The emphasis throughout the book is on ...

  11. BOOK REVIEW: The Current Comparator

    Science.gov (United States)

    Petersons, Oskars

    1989-01-01

    techniques for magnetic errors and magnetic-shield excitation for capacitive errors. The magnetic-shield-excitation technique leads naturally to two-stage transformer approaches, described in a small subchapter. Sensitivity of current comparators is discussed in terms of available signal levels for given excitations and current-comparator characteristics. The discussion, however, does not cover more basic limitations, such as inherent noise. A subchapter is devoted to electronically-aided current transformers. Although electronically-aided transformers are not in a strict sense current comparators, many of the design considerations and error sources are the same. Seven different circuits are presented with a brief qualitative discussion. The third chapter, covering design and construction, will be exceptionally valuable for someone needing basic information on how to construct a current comparator quickly. Indeed, all the necessary design, construction, and testing steps are presented in a well-illustrated 15-page chapter. The tests for shielding effectiveness discussed in this chapter and the knowledge of interwinding capacitances calculable from the equations in the previous chapter should enable one also to predict the limits of errors without an exhaustive and complete calibration. Chapter 4 is devoted to current-transformer calibration—the original objective for the current-comparator development work. The principal tool for this is the compensated current comparator, in effect a two-stage transformer operated in the current-comparator mode. The compensated current comparator is not only accurate but is also an extremely versatile device and, hence, deserves the attention that it receives in this book. Considerable space is devoted to the calibration of current comparators themselves using other current comparators in ratio-buildup (bootstrap) techniques. This information is more than most of the users will want since the pre-eminent feature of a current comparator is

  12. Level up Book Club

    Science.gov (United States)

    LaGarde, Jennifer; Winner, Matthew C.

    2012-01-01

    Like all great ideas, Level Up Book Club grew out of a genuine need, the spontaneous firing of a few brain sparks, and the kind of luck that comes from being "in the right place at the right time." By mid-June 2011 the authors were already "bona fide" wonder twins--two educators who, although they'd never met, had stumbled upon each other through…

  13. The Delights of Books

    Institute of Scientific and Technical Information of China (English)

    徐保国

    2005-01-01

    Books are to mankind what memory is to the individual.They contain the history of our race,the discoveries we have made,the accumulated knowledge and experience of ages;they picture for us the marvels and beauties of nature,help us in our difficulties, comfort us in sorrow and in suffering,change hours of weariness into moments of delight,store our minds with ideas,

  14. Book Reviews Volume 3

    OpenAIRE

    2016-01-01

    Book Reviews Denis McQuail Media Performance: Mass Communication and the Public Interest, Reviewed by Farrel Corcoran. James Donald, Sentimental Education: Schooling, Popular Culture and the Regulation of Liberty London, Reviewed by Sheelagh Drudy Robert Chapman Selling The Sixties: The Pirates and Pop Music Radio, Reviewed by Pat Dunne Bob Franklin, ed. Televising Democracies with a foreword by Bernard Weatherhill , Reviewed by Brian Farrell Tim Congdon et al Paying for Broadc...

  15. The Pricing of Economics Books.

    Science.gov (United States)

    Laband, David; Hudson, John

    2003-01-01

    Examines the pricing and other characteristics of books. Notes substantial increases in book prices between 2000 and 1985 data. Suggests a major factor is the increasing importance of foreign presses that sell books at higher prices. Indicates that discount on paperbacks appear to have been relatively stable in the two years studied. (JEH)

  16. Carter G. Woodson Book Awards.

    Science.gov (United States)

    Social Education, 2000

    2000-01-01

    Presents the recipients of the 1999 Carter G. Woodson book awards that honor books focusing on ethnic minorities and race relations that are appropriate for elementary and secondary levels. Includes books that cover topics such as life for Japanese Americans in internment camps and lives of 12 black women. (CMK)

  17. Electronic Books for Secondary Students.

    Science.gov (United States)

    Anderson-Inman, Lynne; Horney, Mark

    1997-01-01

    Discusses the definition, purposes, and advantages and disadvantages of electronic books. Notes the types of embedded resources present in them, offers an example of an electronic book, and suggests three steps to evaluate and select electronic books for the curriculum. (SR)

  18. Book History and Ideological Hierarchies

    Science.gov (United States)

    Dilevko, Juris; Dali, Keren

    2006-01-01

    The evolving field of Book History has had difficulty in integrating the experiences of immigrant culture. In explaining the origins of print culture in North America, Book History has a tendency to associate lowbrow with immigrants and their struggles to establish a foothold in a new land. Book History therefore symbolically defines immigrant…

  19. [Young children and books].

    Science.gov (United States)

    Diatkine, R; Bonnafé, M; Roy, J; Camus, C; Brandao, C

    1986-01-01

    Children come into contact very early with the written language. The work of Emilia Ferreiro, a student of Piaget, has shown that from early on, well before they can read, they know that the written word has a meaning. Their successive hypotheses show an elaboration which does not occur by chance. Experience shows that babies have a specific interest for a book as an object. They recognize the value of the pictures, as much representations of their mental representations as are words, whereas these two capacities evolve in a complementary fashion. The capacity to be interested by a narrative introduces a new form of organization in the chain of representations, whether they refer to absent or imaginary objects. A good story has a special place among the narratives the child hears, which actually have the specific structures of the written language. The authors of this work report a number of examples of very young children who are put in contact with books. They see in this a new model for mental health work which can be set up by virtue of meetings outside the school rooms, the mental health services, and even of the libraries, by people of different professional skills, in order to loosen the vice of the children's daily routine, and to give the child time to dream with the books, and to draw the adults in to a salutary disorder.

  20. Pi a source book

    CERN Document Server

    Berggren, Lennart; Borwein, Peter

    2004-01-01

    This book documents the history of pi from the dawn of mathematical time to the present. One of the beauties of the literature on pi is that it allows for the inclusion of very modern, yet accessible, mathematics. The articles on pi collected herein include selections from the mathematical and computational literature over four millennia, a variety of historical studies on the cultural significance of the number, and an assortment of anecdotal, fanciful, and simply amusing pieces. For this new edition, the authors have updated the original material while adding new material of historical and cultural interest. There is a substantial exposition of the recent history of the computation of digits of pi, a discussion of the normality of the distribution of the digits, new translations of works by Viete and Huygen, as well as Kaplansky's never-before-published "Song of Pi." From the reviews of earlier editions: "Few mathematics books serve a wider potential readership than does a source book and this particular on...

  1. Inseparable phone books demonstration

    Science.gov (United States)

    Balta, Nuri; Çetin, Ali

    2017-05-01

    This study is aimed at first introducing a well-known discrepant event; inseparable phone books and second, turning it into an experiment for high school or middle school students. This discrepant event could be used especially to indicate how friction force can be effective in producing an unexpected result. Demonstration, discussion, explanation and experiment steps are presented on how to turn a simple discrepant event into an instructional activity. Results showed the relationships between number of pages and force, as well as between amounts of interleave and force. In addition to these, the mathematical equation for the total force between all interleaved pages is derived. As a conclusion, this study demonstrated that not only can phone books be used, but also ordinary books, to investigate this discrepant event. This experiment can be conducted as an example to show the agreement between theoretical and experimental results along with the confounding variables. This discrepant event can be used to create a cognitive conflict in students’ minds about the concepts of ‘force and motion’ and ‘friction force’.

  2. A Brief Discussion on the Problems Faced by the Collec-tion and Arrangement of Ancient Books in Yi Language and the Urgency of Talent Cultivation%浅谈彝文古籍收集整理面临的问题及人才培养的紧迫性

    Institute of Scientific and Technical Information of China (English)

    文启扬

    2014-01-01

    彝文古籍是彝族历史文化发展的结晶,具有政治、经济、哲学、宗教、历史、文学等方面的研究价值,是彝学研究的主要文献来源。彝文古籍卷帙浩繁,内容包罗万象。但近几年来,彝文翻译人才越来越稀少,彝文古籍的收集整理和翻译工作面临很大困难,培养彝文古籍翻译人才已经刻不容缓。%Ancient books in Yi language, as the crystallization of the historical and cultural development of the Yi nationality, is of research value in politics, economics, philosophy, religion, history and literature, and they are also the main literature references of Yi studies. Ancient books in Yi language are numerous and con-tain a lot of things. But in recent years, talents for Yi language translation are increasingly scarce, resulting in great difficulties in the collection, arrangement and translation of ancient books in Yi language, so it is imperative to cultivate talents for the transla-tion of ancient books in Yi language.

  3. Book selling and e-books in Sweden

    Directory of Open Access Journals (Sweden)

    Elena Maceviciute

    2015-07-01

    Full Text Available This paper addresses the issue of the understanding of the book-selling situation as Swedish booksellers see it. It pursues the answers to the following questions: 1. What are the perceptions of Swedish booksellers of the impact of e-books on their business? 2. What drivers are important for Swedish booksellers for adopting and developing e-book sales through their own sales channels? 3. What do they perceive as barriers to e-book selling through their own channels? The authors have employed the analysis of the secondary statistical data and a survey of Swedish booksellers to answer their questions. The results of the investigation have shown that the Swedish booksellers do not feel their bookshops, or business in general, are threatened by e-books. The opinions on e-books do not differ between the few selling e-books and others who do not offer this product. The reasons for selling e-books are well-functioning routines and personal interest in the product. The reasons for not selling the books are the lack of demand and technical resources as well as contractual agreements with e-book publishers or vendors. So, technical resources for e-book sales, routines, and contracts with publishers are the main premises for this activity. The biggest barriers to e-book sales are: a the price as one can see not only in the answers of the booksellers, but also in the drop of sales obviously related to the rise of prices during 2014; b lack of demand from customers who do not enquire about e-books in bookshops. This leads to the belief that e-books will be sold mostly online either directly from publishers and authors or through online booksellers. However, an equal number of booksellers believe that physical bookshops will be selling printed books and e-books in the future. The future of e-books seems to be quite secure and non-threatening to printed books from the point of view of booksellers. The growth of e-book sales is quite slow and the respondents

  4. BOOK REVIEW: Quantum Gravity (2nd edn)

    Science.gov (United States)

    Husain, Viqar

    2008-06-01

    There has been a flurry of books on quantum gravity in the past few years. The first edition of Kiefer's book appeared in 2004, about the same time as Carlo Rovelli's book with the same title. This was soon followed by Thomas Thiemann's 'Modern Canonical Quantum General Relativity'. Although the main focus of each of these books is non-perturbative and non-string approaches to the quantization of general relativity, they are quite orthogonal in temperament, style, subject matter and mathematical detail. Rovelli and Thiemann focus primarily on loop quantum gravity (LQG), whereas Kiefer attempts a broader introduction and review of the subject that includes chapters on string theory and decoherence. Kiefer's second edition attempts an even wider and somewhat ambitious sweep with 'new sections on asymptotic safety, dynamical triangulation, primordial black holes, the information-loss problem, loop quantum cosmology, and other topics'. The presentation of these current topics is necessarily brief given the size of the book, but effective in encapsulating the main ideas in some cases. For instance the few pages devoted to loop quantum cosmology describe how the mini-superspace reduction of the quantum Hamiltonian constraint of LQG becomes a difference equation, whereas the discussion of 'dynamical triangulations', an approach to defining a discretized Lorentzian path integral for quantum gravity, is less detailed. The first few chapters of the book provide, in a roughly historical sequence, the covariant and canonical metric variable approach to the subject developed in the 1960s and 70s. The problem(s) of time in quantum gravity are nicely summarized in the chapter on quantum geometrodynamics, followed by a detailed and effective introduction of the WKB approach and the semi-classical approximation. These topics form the traditional core of the subject. The next three chapters cover LQG, quantization of black holes, and quantum cosmology. Of these the chapter on LQG is

  5. TU-CD-BRB-04: Automated Radiomic Features Complement the Prognostic Value of VASARI in the TCGA-GBM Dataset

    Energy Technology Data Exchange (ETDEWEB)

    Velazquez, E Rios [Dana-Farber Cancer Institute | Harvard Medical School, Boston, MA (United States); Narayan, V [Dana-Farber Cancer Institute, Brigham and Womens Hospital, Harvard Medic, Boston, MA (United States); Grossmann, P [Dana-Farber Cancer Institute/Harvard Medical School, Boston, MA (United States); Dunn, W; Gutman, D [Emory University School of Medicine, Atlanta, GA (United States); Aerts, H [Dana-Farber/Brigham Womens Cancer Center, Boston, MA (United States)

    2015-06-15

    Purpose: To compare the complementary prognostic value of automated Radiomic features to that of radiologist-annotated VASARI features in TCGA-GBM MRI dataset. Methods: For 96 GBM patients, pre-operative MRI images were obtained from The Cancer Imaging Archive. The abnormal tumor bulks were manually defined on post-contrast T1w images. The contrast-enhancing and necrotic regions were segmented using FAST. From these sub-volumes and the total abnormal tumor bulk, a set of Radiomic features quantifying phenotypic differences based on the tumor intensity, shape and texture, were extracted from the post-contrast T1w images. Minimum-redundancy-maximum-relevance (MRMR) was used to identify the most informative Radiomic, VASARI and combined Radiomic-VASARI features in 70% of the dataset (training-set). Multivariate Cox-proportional hazards models were evaluated in 30% of the dataset (validation-set) using the C-index for OS. A bootstrap procedure was used to assess significance while comparing the C-Indices of the different models. Results: Overall, the Radiomic features showed a moderate correlation with the radiologist-annotated VASARI features (r = −0.37 – 0.49); however that correlation was stronger for the Tumor Diameter and Proportion of Necrosis VASARI features (r = −0.71 – 0.69). After MRMR feature selection, the best-performing Radiomic, VASARI, and Radiomic-VASARI Cox-PH models showed a validation C-index of 0.56 (p = NS), 0.58 (p = NS) and 0.65 (p = 0.01), respectively. The combined Radiomic-VASARI model C-index was significantly higher than that obtained from either the Radiomic or VASARI model alone (p = <0.001). Conclusion: Quantitative volumetric and textural Radiomic features complement the qualitative and semi-quantitative annotated VASARI feature set. The prognostic value of informative qualitative VASARI features such as Eloquent Brain and Multifocality is increased with the addition of quantitative volumetric and textural features from the

  6. High affinity of anti-GBM antibodies from Goodpasture and transplanted Alport patients to alpha3(IV)NC1 collagen.

    Science.gov (United States)

    Rutgers, A; Meyers, K E; Canziani, G; Kalluri, R; Lin, J; Madaio, M P

    2000-07-01

    Anti-glomerular basement membrane (anti-GBM) antibody-mediated diseases are characterized by rapidly progressive glomerulonephritis (RPGN) that often results in irreversible loss of renal function and renal failure. Although many factors contribute to the fulminant nature and treatment resistance of this disease, we questioned whether high affinity autoantibody-alpha3(IV) collagen interactions lead to persistent antibody deposition, thereby perpetuating inflammation. To address this hypothesis, the binding kinetics of human anti-GBM antibodies (Ab) to alpha3(IV)NC1 were evaluated using an optical biosensor interaction analysis. Polyclonal anti-GBM Abs were purified by alpha3(IV)NC1 affinity chromatography from the sera of patients with anti-GBM AB-mediated diseases, including individuals with Goodpasture syndrome (GS), idiopathic RPGN (N = 7), and Alport syndrome (AL) following kidney transplantation (N = 4). The affinity-binding characteristics of the autoantibodies were determined using a biosensor analysis system, with immobilized bovine alpha3(IV)NC1 dimers. All of the autoantibody preparations bound to alpha3(IV)NC1, whereas none bound to alpha1(IV)NC1 (control). Purified, normal serum IgG did not bind to either antigen. Estimated dissociation constants (Kd) for the purified autoantibodies were 1.39E-04 +/- 7.30E-05 s-l (GS) and 8. 90E-05 +/- 2.80E-05 s-l (AL). Their estimated association constants (Ka) were 2.67E+04 +/- 1.8E+04 (M-ls-l) and 2.76E+04 +/- 1. 70E+04(M-ls-l) for GS and AL patients, respectively. By comparison with other Ab interactions, these Abs demonstrated high affinity, with relatively high on (binding) rates and slow off (dissociation) rates. The results suggest that anti-GBM Abs bind rapidly and remain tightly bound to the GBM in vivo. This property likely contributes to both the fulminant nature of this disease and its resistance to therapy, because persistent glomerular Ab deposition has the potential to produce continuous inflammation

  7. CERN Scientific Book Fair 2008

    CERN Document Server

    DSU Unit

    2008-01-01

    The CERN Bookshop and CERN Library invite you to attend the 2008 CERN Book Fair 2008, a three-day scientific book festival offering you the opportunity to meet key publishers and electronic book suppliers and to browse and purchase books at significant discounts. Some ten companies will be participating and will bring with them a selection of titles in physics, technology, mathematics, engineering and popular science. There will also be a number of tie-in events intended to give you an insight into the writing and publishing process from authors within our own community. Come along and meet the authors, discuss your book ideas with the publishers’ representatives or simply browse the books on offer. The Fair will take place in Building 500 in the area near the Main Auditorium, and special presentations (as detailed below) will be held in rooms nearby or in the Library. Participating publishers and book traders include: Cambridge ...

  8. Do Adolescents Prefer Electronic Books to Paper Books?

    Directory of Open Access Journals (Sweden)

    Margaret K. Merga

    2015-11-01

    Full Text Available While electronic books offer a range of benefits and may be supposed to be more appealing to young people than paper books, this assumption is often treated as fact by educational researchers. Understanding adolescents’ true current preferences is essential, as incorrect assumptions can lead to decisions which restrict adolescent access to their preferred book mode. The belief that adolescents prefer electronic books to paper books has already led to some school libraries being expunged of paper books. As adolescents show a higher level of aliteracy than younger children, and regular reading offers a broad range of benefits for young people, it is imperative that school’s decisions around providing access to books are responsive to adolescent students’ genuine preferences. This paper analyses the current and relevant academic research around adolescent preferences for book modes, finding that, at present, the contention that adolescents prefer electronic books is not supported by the available research. In addition, there are a number of issues identified that make analyzing the findings in this area problematic. Future studies in this area are needed before an adolescent preference for electronic books can be unequivocally substantiated.

  9. BOOK REVIEW: Once Upon Einstein

    Science.gov (United States)

    Giannetto, E.

    2007-07-01

    Thibault Damour is a theoretical physicist, and a member of the French Academy of Sciences. This book is the translation, by Eric Novak, of the original French Si Einstein m'etait conté (Le Cherche Midi, 2005). It is neither a book of theoretical physics nor a biography of Einstein. It is not a book of history nor philosophy of science. In Damour's words it was written to encourage the reader to share with Einstein `those times when he understood some part of the hidden order of the universe'. It is a relatively short book, written in a very fluent style, but it deals with all the major problems and achievements of Einstein's works. Starting from special relativity, it continues with general relativity, quantum theories, unified field theory and a brief overview of the actual research related to Einstein's legacy. It is essentially a popular science book with some related exploration in history and philosophy to interpret physical theories. The most important problem discussed by Damour is the nature of time. On this subject, there is a very interesting short paragraph (pp 33--35) dedicated to the reception of the relativity idea by the great writer Marcel Proust and its counterpart within À la Recherche du Temps Perdu. A correct discussion of the implications of a relativistic time should imply the distinction of the different possible interpretations of this concept. Damour seems to conclude that only one interpretation is possible: `time does not exist', flowing of time is an illusion. One has to know that Einstein's ideas on time were related to Spinoza's perspective of a knowledge sub specie aeternitatis. However, other interpretations are possible and are related to the idea of time as an actuality. Damour speaks about the controversy between Einstein and Bergson, but Bergson is considered as a philosopher who did not understand relativity. This philosophical problem of relativistic time is indeed related to a historical problem briefly discussed by Damour

  10. Recent developments: Industry briefs

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1990-04-01

    Recent nuclear industry briefs are presented. These briefs include: Soviet Union to build Iran nuclear plant; Dension announces cuts in Elliot Lake production; Soviet environmental study delays Rostov startup; Cogema closes two mines; Namibian sanctions lifted by USA and Canada; US Energy and Kennecott restructors joint venture; Australians reelect Hawke; China to buy Soviet nuclear plant; Olympic Dam`s first sale of concentrates to USA; Uranevz buys one-third of Cogema`s Rabbit Lake operations; East and West Germany forming joint nuclear law; and Nova Scotia extends uranium exploration plan.

  11. Instrumentation reference book

    CERN Document Server

    Boyes, Walt

    2002-01-01

    Instrumentation is not a clearly defined subject, having a 'fuzzy' boundary with a number of other disciplines. Often categorized as either 'techniques' or 'applications' this book addresses the various applications that may be needed with reference to the practical techniques that are available for the instrumentation or measurement of a specific physical quantity or quality. This makes it of direct interest to anyone working in the process, control and instrumentation fields where these measurements are essential.* Comprehensive and authoritative collection of technical information* Writte

  12. Bytes, Books and Readers

    DEFF Research Database (Denmark)

    Rasmussen, Krista Stinne Greve

    2016-01-01

    Geschichte von Editionen und der Entwicklung der Digital Humanities besonderes Augenmerk geschenkt, um zu demonstrieren, wie bedeutsam die Analyse der Überlieferung und der Textbegriff für die Geschichte von Editionen sind. Beispiele aus Alastair McKinnons erster digitaler Edition von Soren Kierkegaards......In diesem Beitrag werden Ergebnisse aus der Dissertation der Autorin Bytes, Books, and Readers. A Historical Analysis of the Transition from Printed to Digital Scholarly Editions Focusing on ‘The Writings of Søren Kierkegaard’ (2015) vorgestellt. Dabei wird dem Wechselverhältnis zwischen der...

  13. The Twitter Book

    CERN Document Server

    O'Reilly, Tim

    2009-01-01

    This practical guide will teach you everything you need to know to quickly become a Twitter power user, including strategies and tactics for using Twitter's 140-character messages as a serious--and effective--way to boost your business. Co-written by Tim O'Reilly and Sarah Milstein, widely followed and highly respected Twitterers, the practical information in The Twitter Book is presented in a fun, full-color format that's packed with helpful examples and clear explanations.A Sneak Preview on SlideShare

  14. The automotive transmission book

    CERN Document Server

    Fischer, Robert; Jürgens, Gunter; Najork, Rolf; Pollak, Burkhard

    2015-01-01

    This book presents essential information on systems and interactions in automotive transmission technology and outlines the methodologies used to analyze and develop transmission concepts and designs. Functions of and interactions between components and subassemblies of transmissions are introduced, providing a basis for designing transmission systems and for determining their potentials and properties in vehicle-specific applications: passenger cars, trucks, buses, tractors, and motorcycles. With these fundamentals the presentation provides universal resources for both state-of-the-art and future transmission technologies, including systems for electric and hybrid electric vehicles.

  15. The Twitter Book

    CERN Document Server

    O'Reilly, Tim

    2011-01-01

    Twitter is not just for talking about your breakfast anymore. It's become an indispensable communications tool for businesses, non-profits, celebrities, and people around the globe. With the second edition of this friendly, full-color guide, you'll quickly get up to speed not only on standard features, but also on new options and nuanced uses that will help you tweet with confidence. Co-written by two widely recognized Twitter experts, The Twitter Book is packed with all-new real-world examples, solid advice, and clear explanations guaranteed to turn you into a power user. Use Twitter to con

  16. Kallikrein transduced mesenchymal stem cells protect against anti-GBM disease and lupus nephritis by ameliorating inflammation and oxidative stress.

    Directory of Open Access Journals (Sweden)

    Yajuan Li

    Full Text Available Previously we have shown that kallikreins (klks play a renoprotective role in nephrotoxic serum induced nephritis. In this study, we have used mesenchymal stem cells (MSCs as vehicles to deliver klks into the injured kidneys and have measured their therapeutic effect on experimental antibody induced nephritis and lupus nephritis. Human KLK-1 (hKLK1 gene was transduced into murine MSCs using a retroviral vector to generate a stable cell line, hKLK1-MSC, expressing high levels of hKLK1. 129/svj mice subjected to anti-GBM induced nephritis were transplanted with 10(6 hKLK1-MSCs and hKLK1 expression was confirmed in the kidneys. Compared with vector-MSCs injected mice, the hKLK1-MSCs treated mice showed significantly reduced proteinuria, blood urea nitrogen (BUN and ameliorated renal pathology. Using the same strategy, we treated lupus-prone B6.Sle1.Sle3 bicongenic mice with hKLK1-MSCs and demonstrated that hKLK1-MSCs delivery also attenuated lupus nephritis. Mechanistically, hKLK1-MSCs reduced macrophage and T-lymphocyte infiltration into the kidney by suppressing the expression of inflammation cytokines. Moreover, hKLK1 transduced MSCs were more resistant to oxidative stress-induced apoptosis. These findings advance genetically modified MSCs as potential gene delivery tools for targeting therapeutic agents to the kidneys in order to modulate inflammation and oxidative stress in lupus nephritis.

  17. The development of mathematics throughout the centuries a brief history in a cultural context

    CERN Document Server

    Evans, Brian

    2014-01-01

    Throughout the book, readers take a journey throughout time and observe how people around the world have understood these patterns of quantity, structure, and dimension around them. The Development of Mathematics Throughout the Centuries: A Brief History in a Cultural Contex provides a brief overview of the history of mathematics in a very straightforward and understandable manner and also addresses major findings that influenced the development of mathematics as a coherent discipline. This book: Highlights the contributions made by various world cultures including African, Egyptian, Babyloni

  18. Fermi Guest Investigator Program Cycle 2 Project Final Report Albedo Polarimetry of Gamma-Ray Bursts and Solar Flares with GBM

    Energy Technology Data Exchange (ETDEWEB)

    Kippen, Richard Marc [Los Alamos National Laboratory

    2012-08-27

    Several key properties of GRBs remain poorly understood and are difficult or even impossible to infer with the information currently being collected. Polarization measurements will probe the precise nature of the central engine. For solar flares, high-energy polarization measurements are expected to be useful in determining the beaming (or directivity) of solar flare electrons - a quantity that may provide important clues about electron acceleration and transport. We propose to investigate the viability of using the Fermi Gamma-ray Burst Monitor (GBM) to measure the polarization of GRBs and solar flares using the albedo photon flux. This approach was previously developed for use with BATSE data. We will conduct a careful study of this technique using a modified version of the GRESS simulation tools developed by the GBM team.

  19. Earth Occultation Imaging Applied to BATSE -- Application to a Combined BATSE-GBM Survey of the Hard X-Ray Sky

    CERN Document Server

    Zhang, Yuan; Case, Gary; Ling, James; Wheaton, William

    2013-01-01

    A combined BATSE-GBM hard X-ray catalog is presented based on Earth Occultation Imaging applied to a reanalysis of BATSE data. An imaging approach has been developed for the reanalysis of Earth Occultation analysis of BATSE data. The standard occultation analysis depends on a predetermined catalog of potential sources, so that a real source not present in the catalog may induce systematic errors when source counts associated with an uncatalogued source are incorrectly attributed to catalog sources. The goal of the imaging analysis is to find a complete set of hard X-ray sources, including sources not in the original BATSE occultation catalog. Using the imaging technique, we have identified 15 known sources and 17 unidentified sources and added them to the BATSE occultation catalog. The resulting expanded BATSE catalog of sources observed during 1991-2000 is compared to the ongoing GBM survey.

  20. Proofs from THE BOOK

    CERN Document Server

    Aigner, Martin

    2014-01-01

    This revised and enlarged fifth edition features four new chapters, which contain highly original and delightful proofs for classics such as the spectral theorem from linear algebra, some more recent jewels like the non-existence of the Borromean rings and other surprises. From the Reviews "... Inside PFTB (Proofs from The Book) is indeed a glimpse of mathematical heaven, where clever insights and beautiful ideas combine in astonishing and glorious ways. There is vast wealth within its pages, one gem after another. ... Aigner and Ziegler... write: "... all we offer is the examples that we have selected, hoping that our readers will share our enthusiasm about brilliant ideas, clever insights and wonderful observations." I do. ... " Notices of the AMS, August 1999 "... This book is a pleasure to hold and to look at: ample margins, nice photos, instructive pictures, and beautiful drawings ... It is a pleasure to read as well: the style is clear and entertaining, the level is close to elementary, the necessary b...