WorldWideScience

Sample records for gamma camera spect

  1. A SPECT demonstrator—revival of a gamma camera

    Science.gov (United States)

    Valastyán, I.; Kerek, A.; Molnár, J.; Novák, D.; Végh, J.; Emri, M.; Trón, L.

    2006-07-01

    A gamma camera has been updated and converted to serve as a demonstrator for educational purposes. The gantry and the camera head were the only part of the system that remained untouched. The main reason for this modernization was to increase the transparency of the gamma camera by partitioning the different logical building blocks of the system and thus providing access for inspection and improvements throughout the chain. New data acquisition and reconstruction software has been installed. By taking these measures, the camera is now used in education and also serves as a platform for tests of new hardware and software solutions. The camera is also used to demonstrate 3D (SPECT) imaging by collecting 2D projections from a rotatable cylindrical phantom. Since the camera head is not attached mechanically to the phantom, the effect of misalignment between the head and the rotation axis of the phantom can be studied.

  2. A SPECT demonstrator-revival of a gamma camera

    International Nuclear Information System (INIS)

    Valastyan, I.; Kerek, A.; Molnar, J.; Novak, D.; Vegh, J.; Emri, M.; Tron, L.

    2006-01-01

    A gamma camera has been updated and converted to serve as a demonstrator for educational purposes. The gantry and the camera head were the only part of the system that remained untouched. The main reason for this modernization was to increase the transparency of the gamma camera by partitioning the different logical building blocks of the system and thus providing access for inspection and improvements throughout the chain. New data acquisition and reconstruction software has been installed. By taking these measures, the camera is now used in education and also serves as a platform for tests of new hardware and software solutions. The camera is also used to demonstrate 3D (SPECT) imaging by collecting 2D projections from a rotatable cylindrical phantom. Since the camera head is not attached mechanically to the phantom, the effect of misalignment between the head and the rotation axis of the phantom can be studied

  3. NEMA NU-1 2007 based and independent quality control software for gamma cameras and SPECT

    International Nuclear Information System (INIS)

    Vickery, A; Joergensen, T; De Nijs, R

    2011-01-01

    A thorough quality assurance of gamma and SPECT cameras requires a careful handling of the measured quality control (QC) data. Most gamma camera manufacturers provide the users with camera specific QC Software. This QC software is indeed a useful tool for the following of day-to-day performance of a single camera. However, when it comes to objective performance comparison of different gamma cameras and a deeper understanding of the calculated numbers, the use of camera specific QC software without access to the source code is rather avoided. Calculations and definitions might differ, and manufacturer independent standardized results are preferred. Based upon the NEMA Standards Publication NU 1-2007, we have developed a suite of easy-to-use data handling software for processing acquired QC data providing the user with instructive images and text files with the results.

  4. Kernel integration scatter model for parallel beam gamma camera and SPECT point source response

    International Nuclear Information System (INIS)

    Marinkovic, P.M.

    2001-01-01

    Scatter correction is a prerequisite for quantitative single photon emission computed tomography (SPECT). In this paper a kernel integration scatter Scatter correction is a prerequisite for quantitative SPECT. In this paper a kernel integration scatter model for parallel beam gamma camera and SPECT point source response based on Klein-Nishina formula is proposed. This method models primary photon distribution as well as first Compton scattering. It also includes a correction for multiple scattering by applying a point isotropic single medium buildup factor for the path segment between the point of scatter an the point of detection. Gamma ray attenuation in the object of imaging, based on known μ-map distribution, is considered too. Intrinsic spatial resolution of the camera is approximated by a simple Gaussian function. Collimator is modeled simply using acceptance angles derived from the physical dimensions of the collimator. Any gamma rays satisfying this angle were passed through the collimator to the crystal. Septal penetration and scatter in the collimator were not included in the model. The method was validated by comparison with Monte Carlo MCNP-4a numerical phantom simulation and excellent results were obtained. The physical phantom experiments, to confirm this method, are planed to be done. (author)

  5. A specially designed cut-off gamma camera for high resolution SPECT of the brain

    International Nuclear Information System (INIS)

    Larsson, S.A.; Bergstrand, G.; Bergstedt, H.; Berg, J.; Flygare, O.; Schnell, P.O.; Anderson, N.; Lagergren, C.

    1984-01-01

    A modern gamma camera system for Single Photon Emission Computed Tomography (SPECT) has been modified in order to optimize examinations of the head. By cutting off a part of the detector housing at one edge, it has been possible to rotate the camera close to the skull, still covering the entire brain and the skull base. The minimum radius of rotation used was thereby reduced, in the mean, from 21.2 cm to 13.0 cm in examination of 18 patients. In combination with an adjustment of the 64 x 64 acquisition matrix to a field of view of 26x26 cm/sup 2/, the spatial resolution improved from 18.6 mm (FWHM) to 12.6 +- 0.3 mm (FWHM) using the conventional LEGP-collimator and to 10.4 +- 0.3 mm (FWHM) using the LEHR-collimator. No other modification than a slight cut of the light guide was made in the internal construction of the camera. Thus, the physical properties of the detector head are not essentially changed from those of a non-modified unit. The improved spatial resolution of the cut-off camera SPECT-system implies certain clinical advantages in studies of the brain, the cerebrospinal fluid (CSF)-space and the skull base

  6. Slit-Slat Collimator Equipped Gamma Camera for Whole-Mouse SPECT-CT Imaging

    Science.gov (United States)

    Cao, Liji; Peter, Jörg

    2012-06-01

    A slit-slat collimator is developed for a gamma camera intended for small-animal imaging (mice). The tungsten housing of a roof-shaped collimator forms a slit opening, and the slats are made of lead foils separated by sparse polyurethane material. Alignment of the collimator with the camera's pixelated crystal is performed by adjusting a micrometer screw while monitoring a Co-57 point source for maximum signal intensity. For SPECT, the collimator forms a cylindrical field-of-view enabling whole mouse imaging with transaxial magnification and constant on-axis sensitivity over the entire axial direction. As the gamma camera is part of a multimodal imaging system incorporating also x-ray CT, five parameters corresponding to the geometric displacements of the collimator as well as to the mechanical co-alignment between the gamma camera and the CT subsystem are estimated by means of bimodal calibration sources. To illustrate the performance of the slit-slat collimator and to compare its performance to a single pinhole collimator, a Derenzo phantom study is performed. Transaxial resolution along the entire long axis is comparable to a pinhole collimator of same pinhole diameter. Axial resolution of the slit-slat collimator is comparable to that of a parallel beam collimator. Additionally, data from an in-vivo mouse study are presented.

  7. Preliminary Experience with Small Animal SPECT Imaging on Clinical Gamma Cameras

    Directory of Open Access Journals (Sweden)

    P. Aguiar

    2014-01-01

    Full Text Available The traditional lack of techniques suitable for in vivo imaging has induced a great interest in molecular imaging for preclinical research. Nevertheless, its use spreads slowly due to the difficulties in justifying the high cost of the current dedicated preclinical scanners. An alternative for lowering the costs is to repurpose old clinical gamma cameras to be used for preclinical imaging. In this paper we assess the performance of a portable device, that is, working coupled to a single-head clinical gamma camera, and we present our preliminary experience in several small animal applications. Our findings, based on phantom experiments and animal studies, provided an image quality, in terms of contrast-noise trade-off, comparable to dedicated preclinical pinhole-based scanners. We feel that our portable device offers an opportunity for recycling the widespread availability of clinical gamma cameras in nuclear medicine departments to be used in small animal SPECT imaging and we hope that it can contribute to spreading the use of preclinical imaging within institutions on tight budgets.

  8. A clinical gamma camera-based pinhole collimated system for high resolution small animal SPECT imaging

    Energy Technology Data Exchange (ETDEWEB)

    Mejia, J.; Galvis-Alonso, O.Y., E-mail: mejia_famerp@yahoo.com.b [Faculdade de Medicina de Sao Jose do Rio Preto (FAMERP), SP (Brazil). Dept. de Biologia Molecular; Castro, A.A. de; Simoes, M.V. [Faculdade de Medicina de Sao Jose do Rio Preto (FAMERP), SP (Brazil). Dept. de Clinica Medica; Leite, J.P. [Universidade de Sao Paulo (FMRP/USP), Ribeirao Preto, SP (Brazil). Fac. de Medicina. Dept. de Neurociencias e Ciencias do Comportamento; Braga, J. [Instituto Nacional de Pesquisas Espaciais (INPE), Sao Jose dos Campos, SP (Brazil). Div. de Astrofisica

    2010-11-15

    The main objective of the present study was to upgrade a clinical gamma camera to obtain high resolution tomographic images of small animal organs. The system is based on a clinical gamma camera to which we have adapted a special-purpose pinhole collimator and a device for positioning and rotating the target based on a computer-controlled step motor. We developed a software tool to reconstruct the target's three-dimensional distribution of emission from a set of planar projections, based on the maximum likelihood algorithm. We present details on the hardware and software implementation. We imaged phantoms and heart and kidneys of rats. When using pinhole collimators, the spatial resolution and sensitivity of the imaging system depend on parameters such as the detector-to-collimator and detector-to-target distances and pinhole diameter. In this study, we reached an object voxel size of 0.6 mm and spatial resolution better than 2.4 and 1.7 mm full width at half maximum when 1.5- and 1.0-mm diameter pinholes were used, respectively. Appropriate sensitivity to study the target of interest was attained in both cases. Additionally, we show that as few as 12 projections are sufficient to attain good quality reconstructions, a result that implies a significant reduction of acquisition time and opens the possibility for radiotracer dynamic studies. In conclusion, a high resolution single photon emission computed tomography (SPECT) system was developed using a commercial clinical gamma camera, allowing the acquisition of detailed volumetric images of small animal organs. This type of system has important implications for research areas such as Cardiology, Neurology or Oncology. (author)

  9. In vivo quantification of {sup 177}Lu with planar whole-body and SPECT/CT gamma camera imaging

    Energy Technology Data Exchange (ETDEWEB)

    Bailey, Dale L. [Department of Nuclear Medicine, Royal North Shore Hospital, St Leonards, NSW 2065 (Australia); Faculty of Health Sciences, University of Sydney, Cumberland, NSW (Australia); Sydney Medical School, University of Sydney, Camperdown, NSW (Australia); NETwork, Sydney Vital, St Leonards, Sydney, NSW (Australia); Hennessy, Thomas M.; Willowson, Kathy P.; Henry, E. Courtney [Institute of Medical Physics, University of Sydney, Camperdown, NSW (Australia); Chan, David L.H. [Department of Nuclear Medicine, Royal North Shore Hospital, St Leonards, NSW 2065 (Australia); NETwork, Sydney Vital, St Leonards, Sydney, NSW (Australia); Aslani, Alireza [Department of Nuclear Medicine, Royal North Shore Hospital, St Leonards, NSW 2065 (Australia); Roach, Paul J. [Department of Nuclear Medicine, Royal North Shore Hospital, St Leonards, NSW 2065 (Australia); Sydney Medical School, University of Sydney, Camperdown, NSW (Australia)

    2015-09-17

    Advances in gamma camera technology and the emergence of a number of new theranostic radiopharmaceutical pairings have re-awakened interest in in vivo quantification with single-photon-emitting radionuclides. We have implemented and validated methodology to provide quantitative imaging of {sup 177}Lu for 2D whole-body planar studies and for 3D tomographic imaging with single-photon emission computed tomography (SPECT)/CT. Whole-body planar scans were performed on subjects to whom a known amount of [{sup 177}Lu]-DOTA-octreotate had been administered for therapy. The total radioactivity estimated from the images was compared with the known amount of the radionuclide therapy administered. In separate studies, venous blood samples were withdrawn from subjects after administration of [{sup 177}Lu]-DOTA-octreotate while a SPECT acquisition was in progress and the concentration of the radionuclide in the venous blood sample compared with that estimated from large blood pool structures in the SPECT reconstruction. The total radioactivity contained within an internal SPECT calibration standard was also assessed. In the whole-body planar scans (n = 28), the estimated total body radioactivity was accurate to within +4.6 ± 5.9 % (range −17.1 to +11.2 %) of the correct value. In the SPECT reconstructions (n = 12), the radioactivity concentration in the cardiac blood pool was accurate to within −4.0 ± 7.8 % (range −16.1 to +7.5 %) of the true value and the internal standard measurements (n = 89) were within 2.0 ± 8.5 % (range −16.3 to +24.2 %) of the known amount of radioactivity contained. In our hands, state-of-the-art hybrid SPECT/CT gamma cameras were able to provide accurate estimates of in vivo radioactivity to better than, on average, ±10 % for use in biodistribution and radionuclide dosimetry calculations.

  10. Realising the SPECT capability of a rotating gamma camera: an alternative approach

    International Nuclear Information System (INIS)

    Morris, P.B.; Sloboda, R.S.; Malik, M.H.

    1984-01-01

    The present paper demonstrates that the SPECT capability of the GE 400T and DEC Gamma-11 combination can be realised without any additional hardware. It is shown that projection data can be collected using acquisition software which already exists as an integral part of the Gamma-11 system. A description of the software which was developed to perform the image reconstruction is also given. The results of two phantom studies verify the validity of the method, which is currently being used regularly in non-routine clinical investigations of the brain and liver. (author)

  11. Gamma camera

    International Nuclear Information System (INIS)

    Tschunt, E.; Platz, W.; Baer, Ul; Heinz, L.

    1978-01-01

    A gamma camera has a plurality of exchangeable collimators, one of which is replaceably mounted in the ray inlet opening of the camera, while the others are placed on separate supports. Supports are swingably mounted upon a column one above the other

  12. Gamma camera

    International Nuclear Information System (INIS)

    Schlosser, P.A.; Steidley, J.W.

    1980-01-01

    The design of a collimation system for a gamma camera for use in nuclear medicine is described. When used with a 2-dimensional position sensitive radiation detector, the novel system can produce superior images than conventional cameras. The optimal thickness and positions of the collimators are derived mathematically. (U.K.)

  13. Calibration of gamma camera systems for a multicentre European {sup 123}I-FP-CIT SPECT normal database

    Energy Technology Data Exchange (ETDEWEB)

    Tossici-Bolt, Livia [Southampton Univ. Hospitals NHS Trust, Dept. of Medical Physics and Bioengineering, Southampton (United Kingdom); Dickson, John C. [UCLH NHS Foundation Trust and Univ. College London, Institute of Nuclear Medicine, London (United Kingdom); Sera, Terez [Univ. of Szeged, Dept. of Nuclear Medicine and Euromedic Szeged, Szeged (Hungary); Nijs, Robin de [Rigshospitalet and Univ. of Copenhagen, Neurobiology Research Unit, Copenhagen (Denmark); Bagnara, Maria Claudia [Az. Ospedaliera Universitaria S. Martino, Medical Physics Unit, Genoa (Italy); Jonsson, Cathrine [Karolinska Univ. Hospital, Dept. of Nuclear Medicine, Medical Physics, Stockholm (Sweden); Scheepers, Egon [Univ. of Amsterdam, Dept. of Nuclear Medicine, Academic Medical Centre, Amsterdam (Netherlands); Zito, Felicia [Fondazione IRCCS Granda, Ospedale Maggiore Policlinico, Dept. of Nuclear Medicine, Milan (Italy); Seese, Anita [Univ. of Leipzig, Dept. of Nuclear Medicine, Leipzig (Germany); Koulibaly, Pierre Malick [Univ. of Nice-Sophia Antipolis, Nuclear Medicine Dept., Centre Antoine Lacassagne, Nice (France); Kapucu, Ozlem L. [Gazi Univ., Faculty of Medicine, Dept. of Nuclear Medicine, Ankara (Turkey); Koole, Michel [Univ. Hospital and K.U. Leuven, Nuclear Medicine, Leuven (Belgium); Raith, Maria [Medical Univ. of Vienna, Dept. of Nuclear Medicine, Vienna (Austria); George, Jean [Univ. Catholique Louvain, Nuclear Medicine Division, Mont-Godinne Medical Center, Mont-Godinne (Belgium); Lonsdale, Markus Nowak [Bispebjerg Univ. Hospital, Dept. of Clinical Physiology and Nuclear Medicine, Copenhagen (Denmark); Muenzing, Wolfgang [Univ. of Munich, Dept. of Nuclear Medicine, Munich (Germany); Tatsch, Klaus [Univ. of Munich, Dept. of Nuclear Medicine, Munich (Germany); Municipal Hospital of Karlsruhe Inc., Dept. of Nuclear Medicine, Karlsruhe (Germany); Varrone, Andrea [Center for Psychiatric Research, Karolinska Inst., Dept. of Clinical Neuroscience, Stockholm (Sweden)

    2011-08-15

    A joint initiative of the European Association of Nuclear Medicine (EANM) Neuroimaging Committee and EANM Research Ltd. aimed to generate a European database of [{sup 123}I]FP-CIT single photon emission computed tomography (SPECT) scans of healthy controls. This study describes the characterization and harmonization of the imaging equipment of the institutions involved. {sup 123}I SPECT images of a striatal phantom filled with striatal to background ratios between 10:1 and 1:1 were acquired on all the gamma cameras with absolute ratios measured from aliquots. The images were reconstructed by a core lab using ordered subset expectation maximization (OSEM) without corrections (NC), with attenuation correction only (AC) and additional scatter and septal penetration correction (ACSC) using the triple energy window method. A quantitative parameter, the simulated specific binding ratio (sSBR), was measured using the ''Southampton'' methodology that accounts for the partial volume effect and compared against the actual values obtained from the aliquots. Camera-specific recovery coefficients were derived from linear regression and the error of the measurements was evaluated using the coefficient of variation (COV). The relationship between measured and actual sSBRs was linear across all systems. Variability was observed between different manufacturers and, to a lesser extent, between cameras of the same type. The NC and AC measurements were found to underestimate systematically the actual sSBRs, while the ACSC measurements resulted in recovery coefficients close to 100% for all cameras (AC range 69-89%, ACSC range 87-116%). The COV improved from 46% (NC) to 32% (AC) and to 14% (ACSC) (p < 0.001). A satisfactory linear response was observed across all cameras. Quantitative measurements depend upon the characteristics of the SPECT systems and their calibration is a necessary prerequisite for data pooling. Together with accounting for partial volume, the

  14. Gamma camera

    International Nuclear Information System (INIS)

    Tschunt, E.; Platz, W.; Baer, U.; Heinz, L.

    1978-01-01

    A gamma camera has a plurality of exchangeable collimators, one of which is mounted in the ray inlet opening of the camera, while the others are placed on separate supports. The supports are swingably mounted upon a column one above the other through about 90 0 to a collimator exchange position. Each of the separate supports is swingable to a vertically aligned position, with limiting of the swinging movement and positioning of the support at the desired exchange position. The collimators are carried on the supports by means of a series of vertically disposed coil springs. Projections on the camera are movable from above into grooves of the collimator at the exchange position, whereupon the collimator is turned so that it is securely prevented from falling out of the camera head

  15. Simulation study of the second-generation MR-compatible SPECT system based on the inverted compound-eye gamma camera design

    Science.gov (United States)

    Lai, Xiaochun; Meng, Ling-Jian

    2018-02-01

    In this paper, we present simulation studies for the second-generation MRI compatible SPECT system, MRC-SPECT-II, based on an inverted compound eye (ICE) gamma camera concept. The MRC-SPECT-II system consists of a total of 1536 independent micro-pinhole-camera-elements (MCEs) distributed in a ring with an inner diameter of 6 cm. This system provides a FOV of 1 cm diameter and a peak geometrical efficiency of approximately 1.3% (the typical levels of 0.1%-0.01% found in modern pre-clinical SPECT instrumentations), while maintaining a sub-500 μm spatial resolution. Compared to the first-generation MRC-SPECT system (MRC-SPECT-I) (Cai 2014 Nucl. Instrum. Methods Phys. Res. A 734 147-51) developed in our lab, the MRC-SPECT-II system offers a similar resolution with dramatically improved sensitivity and greatly reduced physical dimension. The latter should allow the system to be placed inside most clinical and pre-clinical MRI scanners for high-performance simultaneous MRI and SPECT imaging.

  16. Gamma camera

    International Nuclear Information System (INIS)

    Berninger, W.H.

    1975-01-01

    The light pulse output of a scintillator, on which incident collimated gamma rays impinge, is detected by an array of photoelectric tubes each having a convexly curved photocathode disposed in close proximity to the scintillator. Electronic circuitry connected to outputs of the phototubes develops the scintillation event position coordinate electrical signals with good linearity and with substantial independence of the spacing between the scintillator and photocathodes so that the phototubes can be positioned as close to the scintillator as is possible to obtain less distortion in the field of view and improved spatial resolution as compared to conventional planar photocathode gamma cameras

  17. Development of an Optical Fiber-Based MR Compatible Gamma Camera for SPECT/MRI Systems

    Science.gov (United States)

    Yamamoto, Seiichi; Watabe, Tadashi; Kanai, Yasukazu; Watabe, Hiroshi; Hatazawa, Jun

    2015-02-01

    Optical fiber is a promising material for integrated positron emission tomography (PET) and magnetic resonance imaging (MRI) PET/MRI systems. Because its material is plastic, it has no interference between MRI. However, it is unclear whether this material can also be used for a single photon emission tomography (SPECT)/MRI system. For this purpose, we developed an optical fiber-based block detector for a SPECT/MRI system and tested its performance by combining 1.2 ×1.2 ×6 mm Y2SiO5 (YSO) pixels into a 15 ×15 block and was coupled it to an optical fiber image guide that used was 0.5-mm in diameter with 80-cm long double clad fibers. The image guide had 22 ×22 mm rectangular input and an equal size output. The input of the optical fiber-based image guide was bent at 90 degrees, and the output was optically coupled to a 1-in square high quantum efficiency position sensitive photomultiplier tube (HQE-PSPMT). The parallel hole, 7-mm-thick collimator made of tungsten plastic was mounted on a YSO block. The diameter of the collimator holes was 0.8 mm which was positioned one-to-one coupled to the YSO pixels. We evaluated the intrinsic and system performances. We resolved most of the YSO pixels in a two-dimensional histogram for Co-57 gamma photons (122-keV) with an average peak-to-value ratio of 1.5. The energy resolution was 38% full-width at half-maximum (FWHM). The system resolution was 1.7-mm FWHM, 1.5 mm from the collimator surface, and the sensitivity was 0.06%. Images of a Co-57 point source could be successfully obtained inside 0.3 T MRI without serious interference. We conclude that the developed optical fiber-based YSO block detector is promising for SPECT/MRI systems.

  18. Gamma camera

    International Nuclear Information System (INIS)

    Reiss, K.H.; Kotschak, O.; Conrad, B.

    1976-01-01

    A gamma camera with a simplified setup as compared with the state of engineering is described permitting, apart from good localization, also energy discrimination. Behind the usual vacuum image amplifier a multiwire proportional chamber filled with trifluorine bromium methane is connected in series. Localizing of the signals is achieved by a delay line, energy determination by means of a pulse height discriminator. With the aid of drawings and circuit diagrams, the setup and mode of operation are explained. (ORU) [de

  19. Simulation of a multi-detector gamma camera for validation protocols of quantification the activity from SPECT images

    International Nuclear Information System (INIS)

    Lozano Sanchez, A.; Calderon Marin, C.; Gonzalez Gonzalez, J.

    2015-01-01

    The main sources that decreasing accuracy in the estimation of internal absorbed dose has been identified in the methods for the quantification of cumulated activity from scintigraphic imaging, likes the corrections required by the physical and instrumental phenomena related to the formation of those images. The results of the simulation of a dual detector gamma camera E.cam SIEMENS using the Monte Carlo code SIMIND to obtain tomographic SPECT projections are presented here. SIMIND will allow dealing with the contribution of physical interactions and instrumental effects during simulations. Energy resolution, spatial resolution and sensitivity planar were determined with real and simulated systems. The relative differences did not exceed 10%. Energy spectra simulated under different conditions (source in air and water) with the inclusion of interactions in the collimator and phantom were compared. The tomographic sensitivity of a volumetric phantom containing radioactive solutions of 99m Tc and 131 I were determined from real and simulated SPECT images. Two processing protocols were considered: with scatter correction ( 99m Tc dual energy window method and 131 I were calculated after corrections. The results, expressed in terms of the differences relative to the well-know activity value in the phantom inserts improves when attenuation and scattering corrections are applied, obtaining good agreement between the results for real and simulated systems. (Author)

  20. Optimisation of conditions for detecting variations in focal activity in SPECT using the rotating gamma camera

    International Nuclear Information System (INIS)

    Wust, P.; Golde, G.; Schneider, R.; Fiegler, W.; Hedde, J.P.

    1986-01-01

    The signal to noise ratio (quotient of contrast and mean noise) is a quality parameter for identifying activity gaps during single photon emission computed tomography (SPECT). Contrast and mean noise level are site-dependent on the reconstruction plane which is influenced in a complex manner by absorption conditions (strong or weak absorption), modes of rotation (full angle or partial angle imaging), interdependencies of opposing partial projections (arithmetic or geometric mean), magnitude of defect (relative to the resolution of the imaging system), geometry of the object to be measured, and scatter. In the present study the authors performed analysis and graphical representation of the SPECT imaging properties on the basis of model calculations illustrated by phantom measurements. The optimal conditions of examination or evaluation and the diagnostic criteria in SPECT of the heart, liver, brain and pelvis are discussed by comparative calculation of signal to noise ratios in defect identification. (orig.)

  1. Gamma camera

    International Nuclear Information System (INIS)

    Conrad, B.; Heinzelmann, K.G.

    1975-01-01

    A gamma camera is described which obviates the distortion of locating signals generally caused by the varied light conductive capacities of the light conductors in that the flow of light through each light conductor may be varied by means of a shutter. A balancing of the flow of light through each of the individual light conductors, in effect, collective light conductors may be balanced on the basis of their light conductive capacities or properties, so as to preclude a distortion of the locating signals caused by the varied light conductive properties of the light conductors. Each light conductor has associated therewith two, relative to each other, independently adjustable shutters, of which one forms a closure member and the other an adjusting shutter. In this embodiment of the invention it is thus possible to block all of the light conductors leading to a photoelectric transducer, with the exception of those light conductors which are to be balanced. The balancing of the individual light conductors may then be obtained on the basis of the output signals of the photoelectric transducer. (auth)

  2. ISPA - a high accuracy X-ray and gamma camera Exhibition LEPFest 2000

    CERN Multimedia

    2000-01-01

    ISPA offers ... Ten times better resolution than Anger cameras High efficiency single gamma counting Noise reduction by sensitivity to gamma energy ...for Single Photon Emission Computed Tomography (SPECT)

  3. Surface and volume three-dimensional displays of Tc-99m HMPAO brain SPECT images in stroke patients with three-head gamma camera

    International Nuclear Information System (INIS)

    Shih, W.J.; Slevin, J.T.; Schleenbaker, R.E.; Mills, B.J.; Magoun, S.L.; Ryo, U.Y.

    1991-01-01

    This paper evaluates volume and surface 3D displays in Tc-99m HMPAO brain SPECT imaging in stroke patients. Using a triple-head gamma camera interfaced with a 64-bit supercomputer, 20 patients with stroke were studied. Each patient was imaged 30-60 minutes after an intravenous injection of 20 mCi of Tc-99m HMPAO. SPECT images as well as planar images were routinely obtained; volume and surface 3D display then proceeded, with the process requiring 5-10 minutes. Volume and surface 3D displays show the brain from all angles; thus the location and extension of lesion(s) in the brain are much easier to appreciate. While a cerebral lesion(s) was more clearly delineated by surface 3D imaging, crossed cerebellar diaschisis in seven patients was clearly exhibited with volume 3D but not with surface 3D imaging. Volume and surface 3D displays enhance continuity of structures and understanding of spatial relationships

  4. Quality control of plane and tomographic gamma cameras

    International Nuclear Information System (INIS)

    Moretti, J.L.; Roussi, A.

    1993-01-01

    In this article, the authors present different methods of gamma camera quality control in matters of uniformity, spatial resolution, spatial linearity, sensitivity, energy resolution, counting rate performance, SPECT parameters. The authors refer mainly to NEMA standards. 14 figs., 8 tabs

  5. Calibration of gamma camera systems for a multicentre European ¹²³I-FP-CIT SPECT normal database

    DEFF Research Database (Denmark)

    Tossici-Bolt, Livia; Dickson, John C; Sera, Terez

    2011-01-01

    A joint initiative of the European Association of Nuclear Medicine (EANM) Neuroimaging Committee and EANM Research Ltd. aimed to generate a European database of [(123)I]FP-CIT single photon emission computed tomography (SPECT) scans of healthy controls. This study describes the characterization...

  6. Gamma camera system

    International Nuclear Information System (INIS)

    Miller, D.W.; Gerber, M.S.; Schlosser, P.A.; Steidley, J.W.

    1980-01-01

    A detailed description is given of a novel gamma camera which is designed to produce superior images than conventional cameras used in nuclear medicine. The detector consists of a solid state detector (e.g. germanium) which is formed to have a plurality of discrete components to enable 2-dimensional position identification. Details of the electronic processing circuits are given and the problems and limitations introduced by noise are discussed in full. (U.K.)

  7. Gamma ray camera

    International Nuclear Information System (INIS)

    Wang, S.-H.; Robbins, C.D.

    1979-01-01

    An Anger gamma ray camera is improved by the substitution of a gamma ray sensitive, proximity type image intensifier tube for the scintillator screen in the Anger camera. The image intensifier tube has a negatively charged flat scintillator screen, a flat photocathode layer, and a grounded, flat output phosphor display screen, all of which have the same dimension to maintain unit image magnification; all components are contained within a grounded metallic tube, with a metallic, inwardly curved input window between the scintillator screen and a collimator. The display screen can be viewed by an array of photomultipliers or solid state detectors. There are two photocathodes and two phosphor screens to give a two stage intensification, the two stages being optically coupled by a light guide. (author)

  8. Scanning gamma camera

    International Nuclear Information System (INIS)

    Engdahl, L.W.; Batter, J.F. Jr.; Stout, K.J.

    1977-01-01

    A scanning system for a gamma camera providing for the overlapping of adjacent scan paths is described. A collimator mask having tapered edges provides for a graduated reduction in intensity of radiation received by a detector thereof, the reduction in intensity being graduated in a direction normal to the scanning path to provide a blending of images of adjacent scan paths. 31 claims, 15 figures

  9. Gamma camera display system

    International Nuclear Information System (INIS)

    Stout, K.J.

    1976-01-01

    A gamma camera having an array of photomultipliers coupled via pulse shaping circuitry and a resistor weighting circuit to a display for forming an image of a radioactive subject is described. A linearizing circuit is coupled to the weighting circuit, the linearizing circuit including a nonlinear feedback circuit with diode coupling to the weighting circuit for linearizing the correspondence between points of the display and points of the subject. 4 Claims, 5 Drawing Figures

  10. Gate Simulation of a Gamma Camera

    International Nuclear Information System (INIS)

    Abidi, Sana; Mlaouhi, Zohra

    2008-01-01

    Medical imaging is a very important diagnostic because it allows for an exploration of the internal human body. The nuclear imaging is an imaging technique used in the nuclear medicine. It is to determine the distribution in the body of a radiotracers by detecting the radiation it emits using a detection device. Two methods are commonly used: Single Photon Emission Computed Tomography (SPECT) and the Positrons Emission Tomography (PET). In this work we are interested on modelling of a gamma camera. This simulation is based on Monte-Carlo language and in particular Gate simulator (Geant4 Application Tomographic Emission). We have simulated a clinical gamma camera called GAEDE (GKS-1) and then we validate these simulations by experiments. The purpose of this work is to monitor the performance of these gamma camera and the optimization of the detector performance and the the improvement of the images quality. (Author)

  11. New nuclear medicine gamma camera systems

    International Nuclear Information System (INIS)

    Villacorta, Edmundo V.

    1997-01-01

    The acquisition of the Open E.CAM and DIACAM gamma cameras by Makati Medical Center is expected to enhance the capabilities of its nuclear medicine facilities. When used as an aid to diagnosis, nuclear medicine entails the introduction of a minute amount of radioactive material into the patient; thus, no reaction or side-effect is expected. When it reaches the particular target organ, depending on the radiopharmaceutical, a lesion will appear as a decrease (cold) area or increase (hot) area in the radioactive distribution as recorded byu the gamma cameras. Gamma camera images in slices or SPECT (Single Photon Emission Computer Tomography), increase the sensitivity and accuracy in detecting smaller and deeply seated lesions, which otherwise may not be detected in the regular single planar images. Due to the 'open' design of the equipment, claustrophobic patients will no longer feel enclosed during the procedure. These new gamma cameras yield improved resolution and superb image quality, and the higher photon sensitivity shortens imaging acquisition time. The E.CAM, which is the latest generation gamma camera, is featured by its variable angle dual-head system, the only one available in the Philipines, and the excellent choice for Myocardial Perfusion Imaging (MPI). From the usual 45 minutes, the acquisition time for gated SPECT imaging of the heart has now been remarkably reduced to 12 minutes. 'Gated' infers snap-shots of the heart in selected phases of its contraction and relaxation as triggered by ECG. The DIACAM is installed in a room with access outside the main entrance of the department, intended specially for bed-borne patients. Both systems are equipped with a network of high performance Macintosh ICOND acquisition and processing computers. Added to the hardware is the ICON processing software which allows total simultaneous acquisition and processing capabilities in the same operator's terminal. Video film and color printers are also provided. Together

  12. Cervical SPECT Camera for Parathyroid Imaging

    Energy Technology Data Exchange (ETDEWEB)

    None, None

    2012-08-31

    Primary hyperparathyroidism characterized by one or more enlarged parathyroid glands has become one of the most common endocrine diseases in the world affecting about 1 per 1000 in the United States. Standard treatment is highly invasive exploratory neck surgery called Parathyroidectomy. The surgery has a notable mortality rate because of the close proximity to vital structures. The move to minimally invasive parathyroidectomy is hampered by the lack of high resolution pre-surgical imaging techniques that can accurately localize the parathyroid with respect to surrounding structures. We propose to develop a dedicated ultra-high resolution (~ 1 mm) and high sensitivity (10x conventional camera) cervical scintigraphic imaging device. It will be based on a multiple pinhole-camera SPECT system comprising a novel solid state CZT detector that offers the required performance. The overall system will be configured to fit around the neck and comfortably image a patient.

  13. Gamma camera system

    International Nuclear Information System (INIS)

    Miller, D.W.; Gerber, M.S.

    1977-01-01

    A gamma camera system having control components operating in conjunction with a solid state detector is described. The detector is formed of a plurality of discrete components which are associated in geometrical or coordinate arrangement defining a detector matrix to derive coordinate signal outputs. These outputs are selectively filtered and summed to form coordinate channel signals and corresponding energy channel signals. A control feature of the invention regulates the noted summing and filtering performance to derive data acceptance signals which are addressed to further treating components. The latter components include coordinate and enery channel multiplexers as well as energy-responsive selective networks. A sequential control is provided for regulating the signal processing functions of the system to derive an overall imaging cycle

  14. Gamma camera based Positron Emission Tomography: a study of the viability on quantification; Tomografia por emissao de positrons com sistemas PET/SPECT: um estudo da viabilidade de quantifizacao

    Energy Technology Data Exchange (ETDEWEB)

    Pozzo, Lorena

    2005-07-01

    Positron Emission Tomography (PET) is a Nuclear Medicine imaging modality for diagnostic purposes. Pharmaceuticals labeled with positron emitters are used and images which represent the in vivo biochemical process within tissues can be obtained. The positron/electron annihilation photons are detected in coincidence and this information is used for object reconstruction. Presently, there are two types of systems available for this imaging modality: the dedicated systems and those based on gamma camera technology. In this work, we utilized PET/SPECT systems, which also allows for the traditional Nuclear Medicine studies based on single photon emitters. There are inherent difficulties which affect quantification of activity and other indices. They are related to the Poisson nature of radioactivity, to radiation interactions with patient body and detector, noise due to statistical nature of these interactions and to all the detection processes, as well as the patient acquisition protocols. Corrections are described in the literature and not all of them are implemented by the manufacturers: scatter, attenuation, random, decay, dead time, spatial resolution, and others related to the properties of each equipment. The goal of this work was to assess these methods adopted by two manufacturers, as well as the influence of some technical characteristics of PET/SPECT systems on the estimation of SUV. Data from a set of phantoms were collected in 3D mode by one camera and 2D, by the other. We concluded that quantification is viable in PET/SPECT systems, including the estimation of SUVs. This is only possible if, apart from the above mentioned corrections, the camera is well tuned and coefficients for sensitivity normalization and partial volume corrections are applied. We also verified that the shapes of the sources used for obtaining these factors play a role on the final results and should be delt with carefully in clinical quantification. Finally, the choice of the region

  15. Gamma camera system

    International Nuclear Information System (INIS)

    Miller, D.W.; Gerber, M.S.

    1982-01-01

    The invention provides a composite solid state detector for use in deriving a display, by spatial coordinate information, of the distribution or radiation emanating from a source within a region of interest, comprising several solid state detector components, each having a given surface arranged for exposure to impinging radiation and exhibiting discrete interactions therewith at given spatially definable locations. The surface of each component and the surface disposed opposite and substantially parallel thereto are associated with impedence means configured to provide for each opposed surface outputs for signals relating the given location of the interactions with one spatial coordinate parameter of one select directional sense. The detector components are arranged to provide groupings of adjacently disposed surfaces mutually linearly oriented to exhibit a common directional sense of the spatial coordinate parameter. Means interconnect at least two of the outputs associated with each of the surfaces within a given grouping for collecting the signals deriving therefrom. The invention also provides a camera system for imaging the distribution of a source of gamma radiation situated within a region of interest

  16. D-SPECT, a semiconductor camera: Technical aspects and clinical applications

    International Nuclear Information System (INIS)

    Merlin, C.; Bertrand, S.; Kelly, A.; Veyre, A.; Mestas, D.; Cachin, F.; Motreff, P.; Levesque, S.; Cachin, F.; Askienazy, S.

    2010-01-01

    Clinical practice in nuclear medicine has largely changed in the last decade, particularly with the arrival of PET/CT and SPECT/CT. New semiconductor cameras could represent the next evolution in our nuclear medicine practice. Due to the resolution and sensitivity improvement, this technology authorizes fast speed acquisitions, high contrast and resolution images performed with low activity injection. The dedicated cardiology D-SPECT camera (Spectrum Dynamics, Israel) is based on semiconductor technology and provides an original system for collimation and images reconstruction. We describe here our clinical experience in using the D-SPECT with a preliminary study comparing D-D.P.E.C.T. and conventional gamma camera. (authors)

  17. Compton camera study for high efficiency SPECT and benchmark with Anger system

    Science.gov (United States)

    Fontana, M.; Dauvergne, D.; Létang, J. M.; Ley, J.-L.; Testa, É.

    2017-12-01

    Single photon emission computed tomography (SPECT) is at present one of the major techniques for non-invasive diagnostics in nuclear medicine. The clinical routine is mostly based on collimated cameras, originally proposed by Hal Anger. Due to the presence of mechanical collimation, detection efficiency and energy acceptance are limited and fixed by the system’s geometrical features. In order to overcome these limitations, the application of Compton cameras for SPECT has been investigated for several years. In this study we compare a commercial SPECT-Anger device, the General Electric HealthCare Infinia system with a High Energy General Purpose (HEGP) collimator, and the Compton camera prototype under development by the French collaboration CLaRyS, through Monte Carlo simulations (GATE—GEANT4 Application for Tomographic Emission—version 7.1 and GEANT4 version 9.6, respectively). Given the possible introduction of new radio-emitters at higher energies intrinsically allowed by the Compton camera detection principle, the two detectors are exposed to point-like sources at increasing primary gamma energies, from actual isotopes already suggested for nuclear medicine applications. The Compton camera prototype is first characterized for SPECT application by studying the main parameters affecting its imaging performance: detector energy resolution and random coincidence rate. The two detector performances are then compared in terms of radial event distribution, detection efficiency and final image, obtained by gamma transmission analysis for the Anger system, and with an iterative List Mode-Maximum Likelihood Expectation Maximization (LM-MLEM) algorithm for the Compton reconstruction. The results show for the Compton camera a detection efficiency increased by a factor larger than an order of magnitude with respect to the Anger camera, associated with an enhanced spatial resolution for energies beyond 500 keV. We discuss the advantages of Compton camera application

  18. Dynamic imaging with coincidence gamma camera

    International Nuclear Information System (INIS)

    Elhmassi, Ahmed

    2008-01-01

    In this paper we develop a technique to calculate dynamic parameters from data acquired using gamma-camera PET (gc PET). Our method is based on an algorithm development for dynamic SPECT, which processes all decency projection data simultaneously instead of reconstructing a series of static images individually. The algorithm was modified to account for the extra data that is obtained with gc PET (compared with SPEC). The method was tested using simulated projection data for both a SPECT and a gc PET geometry. These studies showed the ability of the code to reconstruct simulated data with a varying range of half-lives. The accuracy of the algorithm was measured in terms of the reconstructed half-life and initial activity for the simulated object. The reconstruction of gc PET data showed improvement in half-life and activity compared to SPECT data of 23% and 20%, respectively (at 50 iterations). The gc PET algorithm was also tested using data from an experimental phantom and finally, applied to a clinical dataset, where the algorithm was further modified to deal with the situation where the activity in certain pixels decreases and then increases during the acquisition. (author)

  19. Analyzer for gamma cameras diagnostic

    International Nuclear Information System (INIS)

    Oramas Polo, I.; Osorio Deliz, J. F.; Diaz Garcia, A.

    2013-01-01

    This research work was carried out to develop an analyzer for gamma cameras diagnostic. It is composed of an electronic system that includes hardware and software capabilities, and operates from the acquisition of the 4 head position signals of a gamma camera detector. The result is the spectrum of the energy delivered by nuclear radiation coming from the camera detector head. This system includes analog processing of position signals from the camera, digitization and the subsequent processing of the energy signal in a multichannel analyzer, sending data to a computer via a standard USB port and processing of data in a personal computer to obtain the final histogram. The circuits are composed of an analog processing board and a universal kit with micro controller and programmable gate array. (Author)

  20. Modeling and simulation of gamma camera

    International Nuclear Information System (INIS)

    Singh, B.; Kataria, S.K.; Samuel, A.M.

    2002-08-01

    Simulation techniques play a vital role in designing of sophisticated instruments and also for the training of operating and maintenance staff. Gamma camera systems have been used for functional imaging in nuclear medicine. Functional images are derived from the external counting of the gamma emitting radioactive tracer that after introduction in to the body mimics the behavior of native biochemical compound. The position sensitive detector yield the coordinates of the gamma ray interaction with the detector and are used to estimate the point of gamma ray emission within the tracer distribution space. This advanced imaging device is thus dependent on the performance of algorithm for coordinate computing, estimation of point of emission, generation of image and display of the image data. Contemporary systems also have protocols for quality control and clinical evaluation of imaging studies. Simulation of this processing leads to understanding of the basic camera design problems. This report describes a PC based package for design and simulation of gamma camera along with the options of simulating data acquisition and quality control of imaging studies. Image display and data processing the other options implemented in SIMCAM will be described in separate reports (under preparation). Gamma camera modeling and simulation in SIMCAM has preset configuration of the design parameters for various sizes of crystal detector with the option to pack the PMT on hexagon or square lattice. Different algorithm for computation of coordinates and spatial distortion removal are allowed in addition to the simulation of energy correction circuit. The user can simulate different static, dynamic, MUGA and SPECT studies. The acquired/ simulated data is processed for quality control and clinical evaluation of the imaging studies. Results show that the program can be used to assess these performances. Also the variations in performance parameters can be assessed due to the induced

  1. Control system for gamma camera

    International Nuclear Information System (INIS)

    Miller, D.W.

    1977-01-01

    An improved gamma camera arrangement is described which utilizing a solid state detector, formed of high purity germanium. the central arrangement of the camera operates to effect the carrying out of a trapezoidal filtering operation over antisymmetrically summed spatial signals through gated integration procedures utilizing idealized integrating intervals. By simultaneously carrying out peak energy evaluation of the input signals, a desirable control over pulse pile-up phenomena is achieved. Additionally, through the use of the time derivative of incoming pulse or signal energy information to initially enable the control system, a low level information evaluation is provided serving to enhance the signal processing efficiency of the camera

  2. Quality control of scintillation cameras (planar and SPECT)

    International Nuclear Information System (INIS)

    Shaekhoon, E.S.

    2008-01-01

    Regular quality control is one of the corner stones of nuclear medicine and a prerequisite for adequate diagnostic imaging. Many papers have been published on quality control of planar and SPECT imaging system up to now, however only minor attenuation has been given to the assessment of the performance of imaging systems. In this research we are going to discuss a comprehensive set of test procedures including regular quality control. Our purpose is to go through analysis of the methods and results then to test our hypothesis which state that there is strong relationship between regular and proper evaluation of quality control and the continuity of better medical services in nuclear medicine department. The selection of the tests is discussed and the tests are described, then results are presented. In addition action thresholds are proposed. The quality control tests can be applied to systems with either a moving detector or a moving image table, and to both detector with a large field of view and detectors with a small field of view. The tests presented on this research do not required special phantoms or sources other than those used for quality control of stationary gamma camera and SPECT. They can be applied for acceptance testing and for performance testing in a regular quality assurance program. The data has been evaluated based on me diso software in comparing with IAEA expert software and system specification within the reference values. Our final results confirm our hypothesis, there are some comments about the characteristics and performance of this system that being observed and solved, then a departmental protocol for routine quality control (Q.C) has being established.(Author)

  3. Decision about buying a gamma camera

    Energy Technology Data Exchange (ETDEWEB)

    Ganatra, R D

    1993-12-31

    A large part of the referral to a nuclear medicine department is usually for imaging studies. Sooner or later, the nuclear medicine specialist will be called upon to make a decision about when and what type of gamma camera to buy. There is no longer an option of choosing between a rectilinear scanner and a gamma camera as the former is virtually out of the market. The decision that one has to make is when to invest in a gamma camera, and then on what basis to select the gamma camera 1 tab., 1 fig

  4. Decision about buying a gamma camera

    International Nuclear Information System (INIS)

    Ganatra, R.D.

    1992-01-01

    A large part of the referral to a nuclear medicine department is usually for imaging studies. Sooner or later, the nuclear medicine specialist will be called upon to make a decision about when and what type of gamma camera to buy. There is no longer an option of choosing between a rectilinear scanner and a gamma camera as the former is virtually out of the market. The decision that one has to make is when to invest in a gamma camera, and then on what basis to select the gamma camera

  5. Ectomography - a tomographic method for gamma camera imaging

    International Nuclear Information System (INIS)

    Dale, S.; Edholm, P.E.; Hellstroem, L.G.; Larsson, S.

    1985-01-01

    In computerised gamma camera imaging the projections are readily obtained in digital form, and the number of picture elements may be relatively few. This condition makes emission techniques suitable for ectomography - a tomographic technique for directly visualising arbitrary sections of the human body. The camera rotates around the patient to acquire different projections in a way similar to SPECT. This method differs from SPECT, however, in that the camera is placed at an angle to the rotational axis, and receives two-dimensional, rather than one-dimensional, projections. Images of body sections are reconstructed by digital filtration and combination of the acquired projections. The main advantages of ectomography - a high and uniform resolution, a low and uniform attenuation and a high signal-to-noise ratio - are obtained when imaging sections close and parallel to a body surface. The filtration eliminates signals representing details outside the section and gives the section a certain thickness. Ectomographic transverse images of a line source and of a human brain have been reconstructed. Details within the sections are correctly visualised and details outside are effectively eliminated. For comparison, the same sections have been imaged with SPECT. (author)

  6. A triple GEM gamma camera for medical application

    Energy Technology Data Exchange (ETDEWEB)

    Anulli, F. [Laboratori Nazionali di Frascati INFN, Frascati (Italy); Balla, A. [Laboratori Nazionali di Frascati INFN, Frascati (Italy); Bencivenni, G. [Laboratori Nazionali di Frascati INFN, Frascati (Italy); Corradi, G. [Laboratori Nazionali di Frascati INFN, Frascati (Italy); D' Ambrosio, C. [Laboratori Nazionali di Frascati INFN, Frascati (Italy); Domenici, D. [Laboratori Nazionali di Frascati INFN, Frascati (Italy); Felici, G. [Laboratori Nazionali di Frascati INFN, Frascati (Italy); Gatta, M. [Laboratori Nazionali di Frascati INFN, Frascati (Italy); Morone, M.C. [Dipartimento di Biopatologia e Diagnostica per immagini, Universita di Roma Tor Vergata (Italy); INFN - Sezione di Roma Tor Vergata (Italy); Murtas, F. [Laboratori Nazionali di Frascati INFN, Frascati (Italy)]. E-mail: fabrizio.murtas@lnf.infn.it; Schillaci, O. [Dipartimento di Biopatologia e Diagnostica per immagini, Universita di Roma Tor Vergata (Italy)

    2007-03-01

    A Gamma Camera for medical applications 10x10cm{sup 2} has been built using a triple GEM chamber prototype. The photon converters placed in front of the three GEM foils, has been realized with different technologies. The chamber, High Voltage supplied with a new active divider made in Frascati, is readout through 64 pads, 1mm{sup 2} wide, organized in a row of 8cm long, with LHCb ASDQ chip. This Gamma Camera can be used both for X-ray movie and PET-SPECT imaging; this chamber prototype is placed in a scanner system, creating images of 8x8cm{sup 2}. Several measurements have been performed using phantom and radioactive sources of Tc99m(140keV) and Na22(511keV). Results on spatial resolution and image reconstruction are presented.

  7. Direct cone beam SPECT reconstruction with camera tilt

    International Nuclear Information System (INIS)

    Jianying Li; Jaszczak, R.J.; Greer, K.L.; Coleman, R.E.; Zongjian Cao; Tsui, B.M.W.

    1993-01-01

    A filtered backprojection (FBP) algorithm is derived to perform cone beam (CB) single-photon emission computed tomography (SPECT) reconstruction with camera tilt using circular orbits. This algorithm reconstructs the tilted angle CB projection data directly by incorporating the tilt angle into it. When the tilt angle becomes zero, this algorithm reduces to that of Feldkamp. Experimentally acquired phantom studies using both a two-point source and the three-dimensional Hoffman brain phantom have been performed. The transaxial tilted cone beam brain images and profiles obtained using the new algorithm are compared with those without camera tilt. For those slices which have approximately the same distance from the detector in both tilt and non-tilt set-ups, the two transaxial reconstructions have similar profiles. The two-point source images reconstructed from this new algorithm and the tilted cone beam brain images are also compared with those reconstructed from the existing tilted cone beam algorithm. (author)

  8. Single photon emission computed tomography of the brain with a rotating gamma camera

    Energy Technology Data Exchange (ETDEWEB)

    Biersack, H J; Knopp, R; Winkler, C; Wappenschmidt, J

    1981-08-01

    In 471 patients SPECT of the brain was performed in addition to conventional serial brain scintigraphy using a rotating gamma camera (GAMMATOME T 9000). 23 patients had tumorous lesions, 26 had vascular lesions, and 422 patients revealed normal brain findings. 5 of the 23 patients with tumorous lesion and 5 of the 12 patients with vascular lesion (anamnesis shorter than 4 weeks) showed positive SPECT results but false negative conventional brain scans. Specificity could be improved up to 98% (412 out of 422 patients) using SPECT and conventional scintigraphy.

  9. Impact of intense x-ray pulses on a NaI(Tl)-based gamma camera

    NARCIS (Netherlands)

    Koppert, Wilco J C; van der Velden, Sandra; Steenbergen, J H Leo; de Jong, Hugo W A M

    2018-01-01

    INTRODUCTION: In SPECT/CT systems X-ray and -ray imaging is performed sequentially. Simultaneous acquisition may have advantages, for instance in interventional settings. However, this may expose a gamma camera to relatively high X-ray doses and deteriorate its functioning. We studied the NaI(Tl)

  10. Gamma camera performance: technical assessment protocol

    Energy Technology Data Exchange (ETDEWEB)

    Bolster, A.A. [West Glasgow Hospitals NHS Trust, London (United Kingdom). Dept. of Clinical Physics; Waddington, W.A. [University College London Hospitals NHS Trust, London (United Kingdom). Inst. of Nuclear Medicine

    1996-12-31

    This protocol addresses the performance assessment of single and dual headed gamma cameras. No attempt is made to assess the performance of any associated computing systems. Evaluations are usually performed on a gamma camera commercially available within the United Kingdom and recently installed at a clinical site. In consultation with the manufacturer, GCAT selects the site and liaises with local staff to arrange a mutually convenient time for assessment. The manufacturer is encouraged to have a representative present during the evaluation. Three to four days are typically required for the evaluation team to perform the necessary measurements. When access time is limited, the team will modify the protocol to test the camera as thoroughly as possible. Data are acquired on the camera`s computer system and are subsequently transferred to the independent GCAT computer system for analysis. This transfer from site computer to the independent system is effected via a hardware interface and Interfile data transfer. (author).

  11. Imaging capabilities of germanium gamma cameras

    International Nuclear Information System (INIS)

    Steidley, J.W.

    1977-01-01

    Quantitative methods of analysis based on the use of a computer simulation were developed and used to investigate the imaging capabilities of germanium gamma cameras. The main advantage of the computer simulation is that the inherent unknowns of clinical imaging procedures are removed from the investigation. The effects of patient scattered radiation were incorporated using a mathematical LSF model which was empirically developed and experimentally verified. Image modifying effects of patient motion, spatial distortions, and count rate capabilities were also included in the model. Spatial domain and frequency domain modeling techniques were developed and used in the simulation as required. The imaging capabilities of gamma cameras were assessed using low contrast lesion source distributions. The results showed that an improvement in energy resolution from 10% to 2% offers significant clinical advantages in terms of improved contrast, increased detectability, and reduced patient dose. The improvements are of greatest significance for small lesions at low contrast. The results of the computer simulation were also used to compare a design of a hypothetical germanium gamma camera with a state-of-the-art scintillation camera. The computer model performed a parametric analysis of the interrelated effects of inherent and technological limitations of gamma camera imaging. In particular, the trade-off between collimator resolution and collimator efficiency for detection of a given low contrast lesion was directly addressed. This trade-off is an inherent limitation of both gamma cameras. The image degrading effects of patient motion, camera spatial distortions, and low count rate were shown to modify the improvements due to better energy resolution. Thus, based on this research, the continued development of germanium cameras to the point of clinical demonstration is recommended

  12. Gamma camera performance: technical assessment protocol

    International Nuclear Information System (INIS)

    Bolster, A.A.; Waddington, W.A.

    1996-01-01

    This protocol addresses the performance assessment of single and dual headed gamma cameras. No attempt is made to assess the performance of any associated computing systems. Evaluations are usually performed on a gamma camera commercially available within the United Kingdom and recently installed at a clinical site. In consultation with the manufacturer, GCAT selects the site and liaises with local staff to arrange a mutually convenient time for assessment. The manufacturer is encouraged to have a representative present during the evaluation. Three to four days are typically required for the evaluation team to perform the necessary measurements. When access time is limited, the team will modify the protocol to test the camera as thoroughly as possible. Data are acquired on the camera's computer system and are subsequently transferred to the independent GCAT computer system for analysis. This transfer from site computer to the independent system is effected via a hardware interface and Interfile data transfer. (author)

  13. Gamma camera with reflectivity mask

    International Nuclear Information System (INIS)

    Stout, K.J.

    1980-01-01

    In accordance with the present invention there is provided a radiographic camera comprising: a scintillator; a plurality of photodectors positioned to face said scintillator; a plurality of masked regions formed upon a face of said scintillator opposite said photdetectors and positioned coaxially with respective ones of said photodetectors for decreasing the amount of internal reflection of optical photons generated within said scintillator. (auth)

  14. An imaging system for a gamma camera

    International Nuclear Information System (INIS)

    Miller, D.W.; Gerber, M.S.

    1980-01-01

    A detailed description is given of a novel gamma camera which is designed to produce superior images than conventional cameras used in nuclear medicine. The detector consists of a solid state detector (e.g. germanium) which is formed to have a plurality of discrete components to enable 2-dimensional position identification. Details of the electronic processing circuits are given and the problems and limitations introduced by noise are discussed in full. (U.K.)

  15. Advanced system for Gamma Cameras modernization

    International Nuclear Information System (INIS)

    Osorio Deliz, J. F.; Diaz Garcia, A.; Arista Romeu, E. J.

    2015-01-01

    Analog and digital gamma cameras still largely used in developing countries. Many of them rely in old hardware electronics, which in many cases limits their use in actual nuclear medicine diagnostic studies. Consequently, there are different worldwide companies that produce medical equipment engaged into a partial or total Gamma Cameras modernization. Present work has demonstrated the possibility of substitution of almost entire signal processing electronics placed at inside a Gamma Camera detector head by a digitizer PCI card. this card includes four 12 Bits Analog-to-Digital-Converters of 50 MHz speed. It has been installed in a PC and controlled through software developed in Lab View. Besides, there were done some changes to the hardware inside the detector head including redesign of the Orientation Display Block (ODA card). Also a new electronic design was added to the Microprocessor Control Block (MPA card) which comprised a PIC micro controller acting as a tuning system for individual Photomultiplier Tubes. The images, obtained by measurement of 99m Tc point radioactive source, using modernized camera head demonstrate its overall performance. The system was developed and tested in an old Gamma Camera ORBITER II SIEMENS GAMMASONIC at National Institute of Oncology and Radiobiology (INOR) under CAMELUD project supported by National Program PNOULU and IAEA . (Author)

  16. [Analog gamma camera digitalization computer system].

    Science.gov (United States)

    Rojas, G M; Quintana, J C; Jer, J; Astudillo, S; Arenas, L; Araya, H

    2004-01-01

    Digitalization of analogue gamma cameras systems, using special acquisition boards in microcomputers and appropriate software for acquisition and processing of nuclear medicine images is described in detail. Microcomputer integrated systems interconnected by means of a Local Area Network (LAN) and connected to several gamma cameras have been implemented using specialized acquisition boards. The PIP software (Portable Image Processing) was installed on each microcomputer to acquire and preprocess the nuclear medicine images. A specialized image processing software has been designed and developed for these purposes. This software allows processing of each nuclear medicine exam, in a semiautomatic procedure, and recording of the results on radiological films. . A stable, flexible and inexpensive system which makes it possible to digitize, visualize, process, and print nuclear medicine images obtained from analogue gamma cameras was implemented in the Nuclear Medicine Division. Such a system yields higher quality images than those obtained with analogue cameras while keeping operating costs considerably lower (filming: 24.6%, fixing 48.2% and developing 26%.) Analogue gamma camera systems can be digitalized economically. This system makes it possible to obtain optimal clinical quality nuclear medicine images, to increase the acquisition and processing efficiency, and to reduce the steps involved in each exam.

  17. Gamma cameras - a method of evaluation

    International Nuclear Information System (INIS)

    Oates, L.; Bibbo, G.

    2000-01-01

    Full text: With the sophistication and longevity of the modern gamma camera it is not often that the need arises to evaluate a gamma camera for purchase. We have recently been placed in the position of retiring our two single headed cameras of some vintage and replacing them with a state of the art dual head variable angle gamma camera. The process used for the evaluation consisted of five parts: (1) Evaluation of the technical specification as expressed in the tender document; (2) A questionnaire adapted from the British Society of Nuclear Medicine; (3) Site visits to assess gantry configuration, movement, patient access and occupational health, welfare and safety considerations; (4) Evaluation of the processing systems offered; (5) Whole of life costing based on equally configured systems. The results of each part of the evaluation were expressed using a weighted matrix analysis with each of the criteria assessed being weighted in accordance with their importance to the provision of an effective nuclear medicine service for our centre and the particular importance to paediatric nuclear medicine. This analysis provided an objective assessment of each gamma camera system from which a purchase recommendation was made. Copyright (2000) The Australian and New Zealand Society of Nuclear Medicine Inc

  18. Performance assessment of gamma cameras. Part 1

    International Nuclear Information System (INIS)

    Elliot, A.T.; Short, M.D.; Potter, D.C.; Barnes, K.J.

    1980-11-01

    The Dept. of Health and Social Security and the Scottish Home and Health Dept. has sponsored a programme of measurements of the important performance characteristics of 15 leading types of gamma cameras providing a routine radionuclide imaging service in hospitals throughout the UK. Measurements have been made of intrinsic resolution, system resolution, non-uniformity, spatial distortion, count rate performance, sensitivity, energy resolution and shield leakage. The main aim of this performance assessment was to provide sound information to the NHS to ease the task of those responsible for the purchase of gamma cameras. (U.K.)

  19. Toward standardising gamma camera quality control procedures

    International Nuclear Information System (INIS)

    Alkhorayef, M.A.; Alnaaimi, M.A.; Alduaij, M.A.; Mohamed, M.O.; Ibahim, S.Y.; Alkandari, F.A.; Bradley, D.A.

    2015-01-01

    Attaining high standards of efficiency and reliability in the practice of nuclear medicine requires appropriate quality control (QC) programs. For instance, the regular evaluation and comparison of extrinsic and intrinsic flood-field uniformity enables the quick correction of many gamma camera problems. Whereas QC tests for uniformity are usually performed by exposing the gamma camera crystal to a uniform flux of gamma radiation from a source of known activity, such protocols can vary significantly. Thus, there is a need for optimization and standardization, in part to allow direct comparison between gamma cameras from different vendors. In the present study, intrinsic uniformity was examined as a function of source distance, source activity, source volume and number of counts. The extrinsic uniformity and spatial resolution were also examined. Proper standard QC procedures need to be implemented because of the continual development of nuclear medicine imaging technology and the rapid expansion and increasing complexity of hybrid imaging system data. The present work seeks to promote a set of standard testing procedures to contribute to the delivery of safe and effective nuclear medicine services. - Highlights: • Optimal parameters for quality control of the gamma camera are proposed. • For extrinsic and intrinsic uniformity a minimum of 15,000 counts is recommended. • For intrinsic flood uniformity the activity should not exceed 100 µCi (3.7 MBq). • For intrinsic uniformity the source to detector distance should be at least 60 cm. • The bar phantom measurement must be performed with at least 15 million counts.

  20. A novel fully integrated handheld gamma camera

    International Nuclear Information System (INIS)

    Massari, R.; Ucci, A.; Campisi, C.; Scopinaro, F.; Soluri, A.

    2016-01-01

    In this paper, we present an innovative, fully integrated handheld gamma camera, namely designed to gather in the same device the gamma ray detector with the display and the embedded computing system. The low power consumption allows the prototype to be battery operated. To be useful in radioguided surgery, an intraoperative gamma camera must be very easy to handle since it must be moved to find a suitable view. Consequently, we have developed the first prototype of a fully integrated, compact and lightweight gamma camera for radiopharmaceuticals fast imaging. The device can operate without cables across the sterile field, so it may be easily used in the operating theater for radioguided surgery. The prototype proposed consists of a Silicon Photomultiplier (SiPM) array coupled with a proprietary scintillation structure based on CsI(Tl) crystals. To read the SiPM output signals, we have developed a very low power readout electronics and a dedicated analog to digital conversion system. One of the most critical aspects we faced designing the prototype was the low power consumption, which is mandatory to develop a battery operated device. We have applied this detection device in the lymphoscintigraphy technique (sentinel lymph node mapping) comparing the results obtained with those of a commercial gamma camera (Philips SKYLight). The results obtained confirm a rapid response of the device and an adequate spatial resolution for the use in the scintigraphic imaging. This work confirms the feasibility of a small gamma camera with an integrated display. This device is designed for radioguided surgery and small organ imaging, but it could be easily combined into surgical navigation systems.

  1. A novel fully integrated handheld gamma camera

    Energy Technology Data Exchange (ETDEWEB)

    Massari, R.; Ucci, A.; Campisi, C. [Biostructure and Bioimaging Institute (IBB), National Research Council of Italy (CNR), Rome (Italy); Scopinaro, F. [University of Rome “La Sapienza”, S. Andrea Hospital, Rome (Italy); Soluri, A., E-mail: alessandro.soluri@ibb.cnr.it [Biostructure and Bioimaging Institute (IBB), National Research Council of Italy (CNR), Rome (Italy)

    2016-10-01

    In this paper, we present an innovative, fully integrated handheld gamma camera, namely designed to gather in the same device the gamma ray detector with the display and the embedded computing system. The low power consumption allows the prototype to be battery operated. To be useful in radioguided surgery, an intraoperative gamma camera must be very easy to handle since it must be moved to find a suitable view. Consequently, we have developed the first prototype of a fully integrated, compact and lightweight gamma camera for radiopharmaceuticals fast imaging. The device can operate without cables across the sterile field, so it may be easily used in the operating theater for radioguided surgery. The prototype proposed consists of a Silicon Photomultiplier (SiPM) array coupled with a proprietary scintillation structure based on CsI(Tl) crystals. To read the SiPM output signals, we have developed a very low power readout electronics and a dedicated analog to digital conversion system. One of the most critical aspects we faced designing the prototype was the low power consumption, which is mandatory to develop a battery operated device. We have applied this detection device in the lymphoscintigraphy technique (sentinel lymph node mapping) comparing the results obtained with those of a commercial gamma camera (Philips SKYLight). The results obtained confirm a rapid response of the device and an adequate spatial resolution for the use in the scintigraphic imaging. This work confirms the feasibility of a small gamma camera with an integrated display. This device is designed for radioguided surgery and small organ imaging, but it could be easily combined into surgical navigation systems.

  2. Fabrication of a phantom and its application for checking gamma camera performance

    International Nuclear Information System (INIS)

    Yesmin, S; Ahmad, G. U.; Afroz, S.; Hossain, S.; Rashid, H.

    2004-01-01

    The primary aim of the present work is to fabricate a total performance phantom, which could be used for checking the performance characteristics of gamma camera. The phantom was locally fabricated at machine shop of Bangladesh University of Engineering and Technology (BUET) and used for checking the performance characteristics of gamma camera LF-61 of Centre for Nuclear Medicine and Ultrasound, Dhaka. With 10 mCi of Tc-99m, imaging of the phantom acquired with a reasonable counts. The image was inspected physically for evaluation of the camera performances. The visual inspection of the phantom image revealed that the performance characteristics like: spatial resolution, linearity, uniformity and lesion detection capability of the gamma camera could clearly be evaluated with reasonable acceptance level. This phantom is expected to be useful for checking performance characteristics of SPECT system as well. (author)

  3. Recent developments in gamma camera technology for myocardial perfusion scintigraphy

    International Nuclear Information System (INIS)

    Bengel, Frank M.

    2010-01-01

    Economic pressure, competition from alternative modalities and an increasing awareness of patient radiation exposure have triggered a rapid development of novel technology for cardiac single-photon emission computed tomography (SPECT) in recent years. The trend clearly goes towards systems with higher sensitivity and resolution, and towards faster acquisition protocols. Those goals are achieved by various measures: On the one hand, several manufacturers have integrated novel semiconductor detector materials together with innovative collimators into dedicated cardiac scanners. On the other hand, new collimators and reconstruction algorithms have lead to increased speed and accuracy of conventional gamma cameras. Imaging times now can be reduced to as much as 10% of that of previous standard protocols, and/or injected activity can be reduced. This is achieved without loss of diagnostic accuracy. These novel developments are still in early phases of clinical implementation. Their potential for a profound change of the clinical practice of myocardial perfusion scintigraphy, however, becomes increasingly obvious. (orig.)

  4. New detection modules for gamma, beta and X-ray cameras

    International Nuclear Information System (INIS)

    Azman, S.; Bolle, E.; Dang, K.Q.; Dang, W.; Dietzel, K.I.; Froberg, T.; Gaarder, P.E.; Gjaerum, J.A.; Haugen, S.H.; Hellum, G.; Henriksen, J.R.; Johanson, T.M.; Kobbevik, A.; Maehlum, G.; Meier, D.; Mikkelsen, S.; Ninive, I.; Oya, P.; Pavlov, N.; Pettersen, D.M.; Sundal, B.M.; Talebi, J.; Yoshioka, K.

    2003-01-01

    Full text: Ideas ASA is developing new detection modules for gamma, beta and X-ray cameras. Recent developments focus on modules using various semi-conductor materials (CZT, HgI, Si). The development includes ASIC design, detector module development, and implementation in camera heads. In this presentation we describe the characteristics of important ASICs and its properties in terms of electronic noise, and the modes for measuring signals (switched current modes, sparsified modes, self triggered modes). The ASICs are specific for detectors and applications. We describe recent developments using various semi - conductor materials. We describe important design aspects for medical applications and in life science (SPECT, beta, X-ray cameras)

  5. Portable mini gamma camera for medical applications

    CERN Document Server

    Porras, E; Benlloch, J M; El-Djalil-Kadi-Hanifi, M; López, S; Pavon, N; Ruiz, J A; Sánchez, F; Sebastiá, A

    2002-01-01

    A small, portable and low-cost gamma camera for medical applications has been developed and clinically tested. This camera, based on a scintillator crystal and a Position Sensitive Photo-Multiplier Tube, has a useful field of view of 4.6 cm diameter and provides 2.2 mm of intrinsic spatial resolution. Its mobility and light weight allow to reach the patient from any desired direction. This camera images small organs with high efficiency and so addresses the demand for devices of specific clinical applications. In this paper, we present the camera and briefly describe the procedures that have led us to choose its configuration and the image reconstruction method. The clinical tests and diagnostic capability are also presented and discussed.

  6. Quantitatively accurate activity measurements with a dedicated cardiac SPECT camera: Physical phantom experiments

    Energy Technology Data Exchange (ETDEWEB)

    Pourmoghaddas, Amir, E-mail: apour@ottawaheart.ca; Wells, R. Glenn [Physics Department, Carleton University, Ottawa, Ontario K1S 5B6, Canada and Cardiology, The University of Ottawa Heart Institute, Ottawa, Ontario K1Y4W7 (Canada)

    2016-01-15

    Purpose: Recently, there has been increased interest in dedicated cardiac single photon emission computed tomography (SPECT) scanners with pinhole collimation and improved detector technology due to their improved count sensitivity and resolution over traditional parallel-hole cameras. With traditional cameras, energy-based approaches are often used in the clinic for scatter compensation because they are fast and easily implemented. Some of the cardiac cameras use cadmium-zinc-telluride (CZT) detectors which can complicate the use of energy-based scatter correction (SC) due to the low-energy tail—an increased number of unscattered photons detected with reduced energy. Modified energy-based scatter correction methods can be implemented, but their level of accuracy is unclear. In this study, the authors validated by physical phantom experiments the quantitative accuracy and reproducibility of easily implemented correction techniques applied to {sup 99m}Tc myocardial imaging with a CZT-detector-based gamma camera with multiple heads, each with a single-pinhole collimator. Methods: Activity in the cardiac compartment of an Anthropomorphic Torso phantom (Data Spectrum Corporation) was measured through 15 {sup 99m}Tc-SPECT acquisitions. The ratio of activity concentrations in organ compartments resembled a clinical {sup 99m}Tc-sestamibi scan and was kept consistent across all experiments (1.2:1 heart to liver and 1.5:1 heart to lung). Two background activity levels were considered: no activity (cold) and an activity concentration 1/10th of the heart (hot). A plastic “lesion” was placed inside of the septal wall of the myocardial insert to simulate the presence of a region without tracer uptake and contrast in this lesion was calculated for all images. The true net activity in each compartment was measured with a dose calibrator (CRC-25R, Capintec, Inc.). A 10 min SPECT image was acquired using a dedicated cardiac camera with CZT detectors (Discovery NM530c, GE

  7. Comparative spect and planar gamma-camera examinations with 2-methoxy-isobutyl-isonitrile and tertier-butyl-isonitrile radiopharmaceuticals labelled with 99mTc on postinfarction patients

    International Nuclear Information System (INIS)

    Horvath, M.; Pszota, A.; Karman, M.; Szalai, M.; Nemeth, L.; Koernyei, J.

    1990-01-01

    The TBI kit is harmless, the labelling easy, but the TBI can be used only with SPECT because of its high hepatic uptake and slower clearance than that of MIBI. Nevertheless the SPECT with dedicated Ketronic-Siemens Medax N programme could correct the hepatic overlap within the inferior region, but the posterior defect appeared more pronounced than with Tl. (author) 5 figs

  8. Monte Carlo simulation for dual head gamma camera

    International Nuclear Information System (INIS)

    Osman, Yousif Bashir Soliman

    2015-12-01

    Monte Carlo (MC) simulation technique was used widely in medical physics applications. In nuclear medicine MC was used to design new medical imaging devices such as positron emission tomography (PET), gamma camera and single photon emission computed tomography (SPECT). Also it can be used to study the factors affecting image quality and internal dosimetry, Gate is on of monte Carlo code that has a number of advantages for simulation of SPECT and PET. There is a limit accessibilities in machines which are used in clinics because of the work load of machines. This makes it hard to evaluate some factors effecting machine performance which must be evaluated routinely. Also because of difficulties of carrying out scientific research and training of students, MC model can be optimum solution for the problem. The aim of this study was to use gate monte Carlo code to model Nucline spirit, medico dual head gamma camera hosted in radiation and isotopes center of Khartoum which is equipped with low energy general purpose LEGP collimators. This was used model to evaluate spatial resolution and sensitivity which is important factor affecting image quality and to demonstrate the validity of gate by comparing experimental results with simulation results on spatial resolution. The gate model of Nuclide spirit, medico dual head gamma camera was developed by applying manufacturer specifications. Then simulation was run. In evaluation of spatial resolution the FWHM was calculated from image profile of line source of Tc 99m gammas emitter of energy 140 KeV at different distances from modeled camera head at 5,10,15,20,22,27,32,37 cm and for these distances the spatial resolution was founded to be 5.76, 7.73, 10.7, 13.8, 14.01,16.91, 19.75 and 21.9 mm, respectively. These results showed a decrement of spatial resolution with increase of the distance between object (line source) and collimator in linear manner. FWHM calculated at 10 cm was compared with experimental results. The

  9. Dynamic gamma camera scintigraphy in primary hypoovarism

    International Nuclear Information System (INIS)

    Peshev, N.; Mladenov, B.; Topalov, I.; Tsanev, Ts.

    1988-01-01

    Twenty-seven patients with primary hypoovarism and 10 controls were examined. After intravenous injection of 111 to 175 MBq 99m Tc pertechnetate, dynamic gamma camera scintigraphy for 15 minutes was carried out. In the patients with primary amenorrhea no functioning ovarial tissue was visualized or the ovaries were diminished in size, strongly reduced and non-homogenous accumulation of the radionuclide with unclear and uneven delineation were observed. In the patients with primary infertility, the gamma camera investigation gave information not only about the presence of ovarial parenchyma, but about the extent of the inflammatory process, too. In the patients after surgical intervention, the dynamic radioisotope investigation gave information about the volume and the site of the surgical intervention, as well as about the conditions of the residual parenchyma

  10. Gamma camera scatter suppression unit WAM

    International Nuclear Information System (INIS)

    Kishi, Haruo; Shibahara, Noriyuki; Hirose, Yoshiharu; Shimonishi, Yoshihiro; Oumura, Masahiro; Ikeda, Hozumi; Hamada, Kunio; Ochi, Hironobu; Itagane, Hiroshi.

    1990-01-01

    In gamma camera imaging, scattered radiation is one of big factors to decrease image contrast. Simply, scatter suppression makes signal to noise ratio larger, but it makes statistics error because of radionuclide injection limit to the human body. EWA is a new method that suppresses scattered radiation and improves image contrast. In this article, WAM which is commercialized EWA method by Siemens Gammasonics Inc. is presented. (author)

  11. Quality assessment of gamma camera systems

    International Nuclear Information System (INIS)

    Kindler, M.

    1985-01-01

    There are methods and equipment in nuclear medical diagnostics that allow selective visualisation of the functioning of organs or organ systems, using radioactive substances for labelling and demonstration of metabolic processes. Following a previous contribution on fundamentals and systems components of a gamma camera system, the article in hand deals with the quality characteristics of such a system and with practical quality control and its significance for clinical applications. [de

  12. Comparison of benzodiazepine receptor SPECT and 18F-FDG PET using a coincidence detection camera in patients with temporal lobe epilepsy: preliminary results

    International Nuclear Information System (INIS)

    Wissmeyer, M.; Geiger, L.; Luescher, D.; Krause, T.; Loevblad, K.; Donati, F.; Wielepp, J.P.

    2002-01-01

    Full text: The aim of this preliminary study was to compare the results of benzodiazepine receptor (BDR) SPECT using 123 I-Iomazenil with those of 18 F-FDG (FDG) PET obtained on a double-headed gamma camera with a coincidence detection system in patients with temporal lobe epilepsy (TLE). We evaluated 6 patients (4 female, 2 male; age range 26-54 years, average 43.5 years) with therapy-refractory TLE due to mesiotemporal sclerosis or other focal brain anomalies. To delineate the epileptogenic zone, clinical evaluation, ictal and interictal surface EEG using the international 10-20 system, brain MRI, interictal CBF SPECT using 99m Tc-ECD, BDR SPECT and FDG coincidence PET were performed. The CBF SPECT, BDR SPECT and coincidence PET scans were viewed independently by 2 observers considering the regional cerebral blood flow, BDR density and FDG uptake asymmetry in the temporal lobe visually as none (0), low (1), moderate (2) and high (3). Ictal and interictal EEG recordings located the epileptogenic focus in all patients in the temporal region. Both the BDR SPECT and the FDG coincidence PET located the epileptogenic focus correctly in circumscribed areas of the temporal lobe in all patients, whereas brain MRI revealed focal anomalies only in 5 of 6 cases . The lateralization to the right (n=4) and left hemisphere (n=2) by interictal CBF SPECT, BDR SPECT and FDG coincidence PET corresponded to the EEG findings in all patients. The visual consideration of the asymmetry revealed a slightly but not statistically significant higher value for the FDG coincidence PET (observer 1: mean 2.333, SD 0.516; observer 2: mean 2.000, SD 0.632) than for the BDR SPECT (observer 1: mean 1.667, SD 1.033; observer 2: mean 1.833, SD 0.753). Visual consideration of the interictal CBF SPECT revealed mean values of 2.000 for both observers. The inter-observer variability was higher in the BDR SPECT than in the FDG coincidence PET and the interictal CBF SPECT, but the difference was not

  13. The making of analog module for gamma camera interface

    International Nuclear Information System (INIS)

    Yulinarsari, Leli; Rl, Tjutju; Susila, Atang; Sukandar

    2003-01-01

    The making of an analog module for gamma camera has been conducted. For computerization of planar gamma camera 37 PMT it has been developed interface hardware technology and software between the planar gamma camera with PC. With this interface gamma camera image information (Originally analog signal) was changed to digital single, therefore processes of data acquisition, image quality increase and data analysis as well as data base processing can be conducted with the help of computers, there are three gamma camera main signals, i.e. X, Y and Z . This analog module makes digitation of analog signal X and Y from the gamma camera that conveys position information coming from the gamma camera crystal. Analog conversion to digital was conducted by 2 converters ADC 12 bit with conversion time 800 ns each, conversion procedure for each coordinate X and Y was synchronized using suitable strobe signal Z for information acceptance

  14. Initial clinical experience with dedicated ultra fast solid state cardiac gamma camera

    International Nuclear Information System (INIS)

    Aland, Nusrat; Lele, V.

    2010-01-01

    Full text: To analyze the imaging and diagnostic performance of new dedicated ultra fast solid state detector gamma camera and compare it with standard dual detector gamma camera in myocardial perfusion imaging. Material and Methods: In total 900 patients underwent myocardial perfusion imaging between 1st February 2010 and 29th August 2010 either stress/rest or rest/stress protocol. There was no age or gender bias (there were 630 males and 270 females). 5 and 15 mCi of 99m Tc - Tetrofosmin/MIBI was injected for 1st and 2nd part of the study respectively. Waiting period after injection was 20 min for regular stress and 40 min for pharmacological stress and 40 min after rest injection. Acquisition was performed on solid state detector gamma camera for a duration of 5 min and 3 min for 1st and 2nd part respectively. Interpretation of myocardial perfusion was done and QGS/QPS protocol was used for EF analysis. Out of these, 20 random patients underwent back to back myocardial perfusion SPECT imaging on standard dual detector gamma camera on same day. There was no age or gender bias (there were 9 males, 11 females). Acquisition time was 20 min for each part of the study. Interpretation was done using Autocard and EF analyses with 4 DM SPECT. Images obtained were then compared with those of solid state detector gamma camera. Result: Good quality and high count myocardial perfusion images were obtained with lesser amount of tracer activity on solid state detector gamma camera. Obese patients also showed good quality images with less tracer activity. As compared to conventional dual detector gamma camera images were brighter and showed better contrast with solid state gamma camera. Right ventricular imaging was better seen. Analyses of diastolic dysfunction was possible with 16 frame gated studies with solid state gamma camera. Shorter acquisition time with comfortable position reduced possibility of patient motion. All cardiac views were obtained with no movement of the

  15. Gamma camera based FDG PET in oncology

    International Nuclear Information System (INIS)

    Park, C. H.

    2002-01-01

    Positron Emission Tomography(PET) was introduced as a research tool in the 1970s and it took about 20 years before PET became an useful clinical imaging modality. In the USA, insurance coverage for PET procedures in the 1990s was the turning point, I believe, for this progress. Initially PET was used in neurology but recently more than 80% of PET procedures are in oncological applications. I firmly believe, in the 21st century, one can not manage cancer patients properly without PET and PET is very important medical imaging modality in basic and clinical sciences. PET is grouped into 2 categories; conventional (c) and gamma camera based ( CB ) PET. CB PET is more readily available utilizing dual-head gamma cameras and commercially available FDG to many medical centers at low cost to patients. In fact there are more CB PET in operation than cPET in the USA. CB PET is inferior to cPET in its performance but clinical studies in oncology is feasible without expensive infrastructures such as staffing, rooms and equipments. At Ajou university Hospital, CBPET was installed in late 1997 for the first time in Korea as well as in Asia and the system has been used successfully and effectively in oncological applications. Our was the fourth PET operation in Korea and I believe this may have been instrumental for other institutions got interested in clinical PET. The following is a brief description of our clinical experience of FDG CBPET in oncology

  16. Development of gamma camera and application to decontamination

    International Nuclear Information System (INIS)

    Yoshida, Akira; Moro, Eiji; Takahashi, Isao

    2013-01-01

    A gamma camera has been developed to support recovering from the contamination caused by the accident of Fukushima Dai-ichi Nuclear Power Plant of Tokyo Electric Power Company. The gamma camera enables recognition of the contamination by visualizing radioactivity. The gamma camera has been utilized for risk communication (explanation to community resident) at local governments in Fukushima. From now on, the gamma camera will be applied to solve decontaminations issues; improving efficiency of decontamination, visualizing the effect of decontamination work and reducing radioactive waste. (author)

  17. MO-AB-206-02: Testing Gamma Cameras Based On TG177 WG Report

    Energy Technology Data Exchange (ETDEWEB)

    Halama, J. [Loyola Univ. Medical Center (United States)

    2016-06-15

    This education session will cover the physics and operation principles of gamma cameras and PET scanners. The first talk will focus on PET imaging. An overview of the principles of PET imaging will be provided, including positron decay physics, and the transition from 2D to 3D imaging. More recent advances in hardware and software will be discussed, such as time-of-flight imaging, and improvements in reconstruction algorithms that provide for options such as depth-of-interaction corrections. Quantitative applications of PET will be discussed, as well as the requirements for doing accurate quantitation. Relevant performance tests will also be described. Learning Objectives: Be able to describe basic physics principles of PET and operation of PET scanners. Learn about recent advances in PET scanner hardware technology. Be able to describe advances in reconstruction techniques and improvements Be able to list relevant performance tests. The second talk will focus on gamma cameras. The Nuclear Medicine subcommittee has charged a task group (TG177) to develop a report on the current state of physics testing of gamma cameras, SPECT, and SPECT/CT systems. The report makes recommendations for performance tests to be done for routine quality assurance, annual physics testing, and acceptance tests, and identifies those needed satisfy the ACR accreditation program and The Joint Commission imaging standards. The report is also intended to be used as a manual with detailed instructions on how to perform tests under widely varying conditions. Learning Objectives: At the end of the presentation members of the audience will: Be familiar with the tests recommended for routine quality assurance, annual physics testing, and acceptance tests of gamma cameras for planar imaging. Be familiar with the tests recommended for routine quality assurance, annual physics testing, and acceptance tests of SPECT systems. Be familiar with the tests of a SPECT/CT system that include the CT images

  18. MO-AB-206-02: Testing Gamma Cameras Based On TG177 WG Report

    International Nuclear Information System (INIS)

    Halama, J.

    2016-01-01

    This education session will cover the physics and operation principles of gamma cameras and PET scanners. The first talk will focus on PET imaging. An overview of the principles of PET imaging will be provided, including positron decay physics, and the transition from 2D to 3D imaging. More recent advances in hardware and software will be discussed, such as time-of-flight imaging, and improvements in reconstruction algorithms that provide for options such as depth-of-interaction corrections. Quantitative applications of PET will be discussed, as well as the requirements for doing accurate quantitation. Relevant performance tests will also be described. Learning Objectives: Be able to describe basic physics principles of PET and operation of PET scanners. Learn about recent advances in PET scanner hardware technology. Be able to describe advances in reconstruction techniques and improvements Be able to list relevant performance tests. The second talk will focus on gamma cameras. The Nuclear Medicine subcommittee has charged a task group (TG177) to develop a report on the current state of physics testing of gamma cameras, SPECT, and SPECT/CT systems. The report makes recommendations for performance tests to be done for routine quality assurance, annual physics testing, and acceptance tests, and identifies those needed satisfy the ACR accreditation program and The Joint Commission imaging standards. The report is also intended to be used as a manual with detailed instructions on how to perform tests under widely varying conditions. Learning Objectives: At the end of the presentation members of the audience will: Be familiar with the tests recommended for routine quality assurance, annual physics testing, and acceptance tests of gamma cameras for planar imaging. Be familiar with the tests recommended for routine quality assurance, annual physics testing, and acceptance tests of SPECT systems. Be familiar with the tests of a SPECT/CT system that include the CT images

  19. Comparison between stress myocardial perfusion SPECT recorded with cadmium-zinc-telluride and Anger cameras in various study protocols

    International Nuclear Information System (INIS)

    Verger, Antoine; Karcher, Gilles; Djaballah, Wassila; Fourquet, Nicolas; Rouzet, Francois; Le Guludec, Dominique; Koehl, Gregoire; Roch, Veronique; Imbert, Laetitia; Poussier, Sylvain; Fay, Renaud; Marie, Pierre-Yves

    2013-01-01

    The results of stress myocardial perfusion SPECT could be enhanced by new cadmium-zinc-telluride (CZT) cameras, although differences compared to the results with conventional Anger cameras remain poorly known for most study protocols. This study was aimed at comparing the results of CZT and Anger SPECT according to various study protocols while taking into account the influence of obesity. The study population, which was from three different institutions equipped with identical CZT cameras, comprised 276 patients referred for study using protocols involving 201 Tl (n = 120) or 99m Tc-sestamibi injected at low dose at stress ( 99m Tc-Low; stress/rest 1-day protocol; n = 110) or at high dose at stress ( 99m Tc-High; rest/stress 1-day or 2-day protocol; n = 46). Each Anger SPECT scan was followed by a high-speed CZT SPECT scan (2 to 4 min). Agreement rates between CZT and Anger SPECT were good irrespective of the study protocol (for abnormal SPECT, 201 Tl 92 %, 99m Tc-Low 86 %, 99m Tc-High 98 %), although quality scores were much higher for CZT SPECT with all study protocols. Overall correlations were high for the extent of myocardial infarction (r = 0.80) and a little lower for ischaemic areas (r = 0.72), the latter being larger on Anger SPECT (p 201 Tl or 99m Tc-Low group and in whom stress myocardial counts were particularly low with Anger SPECT (228 ± 101 kcounts) and dramatically enhanced with CZT SPECT (+279 ± 251 %). Concordance between the results of CZT and Anger SPECT is good regardless of study protocol and especially when excluding obese patients who have low-count Anger SPECT and for whom myocardial counts are dramatically enhanced on CZT SPECT. (orig.)

  20. Comparison between stress myocardial perfusion SPECT recorded with cadmium-zinc-telluride and Anger cameras in various study protocols

    Energy Technology Data Exchange (ETDEWEB)

    Verger, Antoine; Karcher, Gilles [CHU-Nancy, Department of Nuclear Medicine, Nancy (France); INSERM U947, Nancy (France); Nancyclotep Experimental Imaging Platform, Nancy (France); Djaballah, Wassila [CHU-Nancy, Department of Nuclear Medicine, Nancy (France); INSERM U947, Nancy (France); Fourquet, Nicolas [Clinique Pasteur, Toulouse (France); Rouzet, Francois; Le Guludec, Dominique [AP-HP, Hopital Bichat, Department of Nuclear Medicine, Paris (France); INSERM U 773 Inserm and Denis Diderot University, Paris (France); Koehl, Gregoire; Roch, Veronique [CHU-Nancy, Department of Nuclear Medicine, Nancy (France); Nancyclotep Experimental Imaging Platform, Nancy (France); Imbert, Laetitia [CHU-Nancy, Department of Nuclear Medicine, Nancy (France); Nancyclotep Experimental Imaging Platform, Nancy (France); Centre Alexis Vautrin, Department of Radiotherapy, Vandoeuvre (France); Poussier, Sylvain [INSERM U947, Nancy (France); Nancyclotep Experimental Imaging Platform, Nancy (France); Fay, Renaud [INSERM, Centre d' Investigation Clinique CIC-P 9501, Nancy (France); Marie, Pierre-Yves [CHU-Nancy, Department of Nuclear Medicine, Nancy (France); Nancyclotep Experimental Imaging Platform, Nancy (France); INSERM U961, Nancy (France); Hopital de Brabois, CHU-Nancy, Medecine Nucleaire, Vandoeuvre-les-Nancy (France)

    2013-03-15

    The results of stress myocardial perfusion SPECT could be enhanced by new cadmium-zinc-telluride (CZT) cameras, although differences compared to the results with conventional Anger cameras remain poorly known for most study protocols. This study was aimed at comparing the results of CZT and Anger SPECT according to various study protocols while taking into account the influence of obesity. The study population, which was from three different institutions equipped with identical CZT cameras, comprised 276 patients referred for study using protocols involving {sup 201}Tl (n = 120) or {sup 99m}Tc-sestamibi injected at low dose at stress ({sup 99m}Tc-Low; stress/rest 1-day protocol; n = 110) or at high dose at stress ({sup 99m}Tc-High; rest/stress 1-day or 2-day protocol; n = 46). Each Anger SPECT scan was followed by a high-speed CZT SPECT scan (2 to 4 min). Agreement rates between CZT and Anger SPECT were good irrespective of the study protocol (for abnormal SPECT, {sup 201}Tl 92 %, {sup 99m}Tc-Low 86 %, {sup 99m}Tc-High 98 %), although quality scores were much higher for CZT SPECT with all study protocols. Overall correlations were high for the extent of myocardial infarction (r = 0.80) and a little lower for ischaemic areas (r = 0.72), the latter being larger on Anger SPECT (p < 0.001). This larger extent was mainly observed in 50 obese patients who were in the {sup 201}Tl or {sup 99m}Tc-Low group and in whom stress myocardial counts were particularly low with Anger SPECT (228 {+-} 101 kcounts) and dramatically enhanced with CZT SPECT (+279 {+-} 251 %). Concordance between the results of CZT and Anger SPECT is good regardless of study protocol and especially when excluding obese patients who have low-count Anger SPECT and for whom myocardial counts are dramatically enhanced on CZT SPECT. (orig.)

  1. Feasibility study of a novel general purpose CZT-based digital SPECT camera: initial clinical results.

    Science.gov (United States)

    Goshen, Elinor; Beilin, Leonid; Stern, Eli; Kenig, Tal; Goldkorn, Ronen; Ben-Haim, Simona

    2018-03-14

    The performance of a prototype novel digital single-photon emission computed tomography (SPECT) camera with multiple pixelated CZT detectors and high sensitivity collimators (Digital SPECT; Valiance X12 prototype, Molecular Dynamics) was evaluated in various clinical settings. Images obtained in the prototype system were compared to images from an analog camera fitted with high-resolution collimators. Clinical feasibility, image quality, and diagnostic performance of the prototype were evaluated in 36 SPECT studies in 35 patients including bone (n = 21), brain (n = 5), lung perfusion (n = 3), and parathyroid (n = 3) and one study each of sentinel node and labeled white blood cells. Images were graded on a scale of 1-4 for sharpness, contrast, overall quality, and diagnostic confidence. Digital CZT SPECT provided a statistically significant improvement in sharpness and contrast in clinical cases (mean score of 3.79 ± 0.61 vs. 3.26 ± 0.50 and 3.92 ± 0.29 vs. 3.34 ± 0.47 respectively, p < 0.001 for both). Overall image quality was slightly higher for the digital SPECT but not statistically significant (3.74 vs. 3.66). CZT SPECT provided significantly improved image sharpness and contrast compared to the analog system in the clinical settings evaluated. Further studies will evaluate the diagnostic performance of the system in large patient cohorts in additional clinical settings.

  2. An energy-optimized collimator design for a CZT-based SPECT camera

    International Nuclear Information System (INIS)

    Weng, Fenghua; Bagchi, Srijeeta; Zan, Yunlong; Huang, Qiu; Seo, Youngho

    2016-01-01

    In single photon emission computed tomography, it is a challenging task to maintain reasonable performance using only one specific collimator for radiotracers over a broad spectrum of diagnostic photon energies, since photon scatter and penetration in a collimator differ with the photon energy. Frequent collimator exchanges are inevitable in daily clinical SPECT imaging, which hinders throughput while subjecting the camera to operational errors and damage. Our objective is to design a collimator, which is independent of the photon energy, performs reasonably well for commonly used radiotracers with low- to medium-energy levels of gamma emissions. Using the Geant4 simulation toolkit, we simulated and evaluated a parallel-hole collimator mounted to a CZT detector. With the pixel-geometry-matching collimation, the pitch of the collimator hole was fixed to match the pixel size of the CZT detector throughout this work. Four variables, hole shape, hole length, hole radius/width and the source-to-collimator distance were carefully studied. Scatter and penetration of the collimator, sensitivity and spatial resolution of the system were assessed for four radionuclides including "5"7Co, "9"9"mTc, "1"2"3I and "1"1"1In, with respect to the aforementioned four variables. An optimal collimator was then decided upon such that it maximized the total relative sensitivity (TRS) for the four considered radionuclides while other performance parameters, such as scatter, penetration and spatial resolution, were benchmarked to prevalent commercial scanners and collimators. Digital phantom studies were also performed to validate the system with the optimal square-hole collimator (23 mm hole length, 1.28 mm hole width, and 0.32 mm septal thickness) in terms of contrast, contrast-to-noise ratio and recovery ratio. This study demonstrates promise of our proposed energy-optimized collimator to be used in a CZT-based gamma camera, with comparable or even better imaging performance versus

  3. Positron emission tomography with gamma camera in coincidence mode

    International Nuclear Information System (INIS)

    Hertel, A.; Hoer, G.

    1999-01-01

    Positron emission tomography using F-18 FDG has been estbalished in clinical diagnostics with first indications especially in oncology. To install a conventional PET tomography (dedicated PET) is financially costly and restricted to PET examinations only. Increasing demand for PET diagnostics on one hand and restricted financial resources in the health system on the other hand led industry to develop SPECT cameras to be operated in coincidence mode (camera PET) in order to offer nuclear medicine physicians cost-effective devices for PET diagnostic. At the same time camera PET is inferior to conventional PET regarding sensitivity and detection-efficiency for 511 keV photons. Does camera-PET offer a reliable alternative to conventional PET? The first larger comparative studies are now available, so a first apraisal about the technical clinical performance of camera-PET can be done. (orig.) [de

  4. Evaluation of different physical parameters that affect the clinical image quality for gamma camera by using different radionuclides

    International Nuclear Information System (INIS)

    Salah, F.A.; Ziada, G.; Hejazy, M.A.; Khalil, W.A.

    2008-01-01

    Some scintillation camera manufactures adhere to standard code of performance specification established by National Electric Manufactures Association (NEMA). Items such as differential and integral uniformity, spatial resolution energy resolution, etc. are all calculated with reproducible methodology that allows the user reliable technique for creation of these standards to avoid any lack of clinical service that may violate the ethics of patient care. Because 99m Tc is the most frequently used radionuclide in nuclear medicine, many clinics perform the daily uniformity and weekly resolution checks using this radionuclide. But when other commonly used radionuclide such as Tl-201,Ga-67 and I-131 are used, no standardized quality control is performed. So in these study we perform to evaluate the response of ADAC(digital) gamma camera and SELO(analogue) gamma camera to four radionuclide (Tl-201,Ga-67, I-131, and 99m Tc) flood image acquired using different non-uniformity correction tables. In the planer study uniformity and resolution images were obtained using ADAC and SELO cameras, linearity was obtained only by ADAC camera, while in the SPECT study uniformity and contrast images were obtained using ADAC camera only. The response for using different non-uniformity correction tables acquired using different isotopes was different from gamma camera model to another. We can conclude that the most of the gamma camera quality control parameters (uniformity, resolution and contrast) are influenced by variation in the correction tables, while other parameters not affected by this variation like linearity. (author)

  5. A very accurate method for sentinel lymph node investigation: Gamma detecting probe associated with SPECT examination for depth

    International Nuclear Information System (INIS)

    Ascoli, G.; Cinti, P.; Nonni, M.; Rossi, B.

    2002-01-01

    Aim: aim of this study is to magnify the lymphoscintigraphy examination by gamma probe with SPECT acquisition for very accurate detection of depth of axilla node in patients affected by melanoma. Methods: according to physiological peculiarities the lymphatic system plays a very important role and represents the most important barrier to neoplastic cells spreading. The 'sentinel node' is the first lymph node draining the affected area. The tendency for surgery is a 'preventive' axillary dissection, even in presence of a clinically negative examination. In fact a high percentage of clinically negative lymph node shows a positive histology (presence of metastatic cells). The nuclear medicine method for researching 'sentinel node' is represented by a regional lymphoscintigraphy with normal gamma camera with a large field of view followed by examination with gamma detecting probe and, in following day, controlled in operating room to confirm the presence of the node early identified. We have completed this protocol with SPECT examination of affected axilla by use of injected laboratory capillary around axilla to perform an exact investigation of node depth. Discussion: Our experience in 150 cases in 18 months shows 100% of axilla 'sentinel node' detection, 25 cases with positive histologic examination and subsequently axillary dissection. Conclusions: In conclusion the scintigraphic examination with lymphoscintigraphy represents a good tool for management of patient with melanoma and the use of ''targeting' with collimated SPECT represent a very aid for the surgeon in reduction time for detection and dissection of lymph node, with high reduction of anesthesia duration

  6. The implementation of quality controls of gamma camera functioning and simulation of tomography techniques by Gate and GEANT4

    International Nuclear Information System (INIS)

    Ben Ameur, Narjes

    2011-01-01

    The reliability of medical devices is directly linked to the services quality offered to the patient. For this reason, quality control tests should be regularly conducted in every nuclear medicine service according to international norms. Our approach consists on realizing different quality control tests recommended by the Nema norm on a gamma-camera in order to evaluate its performance. The obtained data allowed us to study the different physical phenomena happening during a SPECT exam. It also allowed us to identify those affecting the image quality based on the simulation programmes: GEANT 4 and Gate. The obtained results of the quality control showed that the Gamma-camera has a high performance in terms of spatial resolution, linearity, uniformity and rotational center. The establishment of a model for a gamma-camera Symbia E (Siemens) using a Gate platform confirms the reliability of this platform in the conception and the optimization of the detectors.

  7. The use of a portable gamma camera for preoperative lymphatic mapping: a comparison with a conventional gamma camera

    Energy Technology Data Exchange (ETDEWEB)

    Vidal-Sicart, Sergi; Paredes, Pilar [Hospital Clinic Barcelona, Nuclear Medicine Department (CDIC), Barcelona (Spain); Institut d' Investigacio Biomedica Agusti Pi Sunyer (IDIBAPS), Barcelona (Spain); Vermeeren, Lenka; Valdes-Olmos, Renato A. [Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital (NKI-AVL), Nuclear Medicine Department, Amsterdam (Netherlands); Sola, Oriol [Hospital Clinic Barcelona, Nuclear Medicine Department (CDIC), Barcelona (Spain)

    2011-04-15

    Planar lymphoscintigraphy is routinely used for preoperative sentinel node visualization, but large gamma cameras are not always available. We evaluated the reproducibility of lymphatic mapping with a smaller and portable gamma camera. In two centres, 52 patients with breast cancer received preoperative lymphoscintigraphy with a conventional gamma camera with a field of view of 40 x 40 cm. Static anterior and lateral images were performed at 15 min, 2 h and 4 h after injection of the radiotracer ({sup 99m}Tc-nanocolloid). At 2 h after injection, anterior and oblique images were also performed with a portable gamma camera (Sentinella, Oncovision) positioned to obtain a field of view of 20 x 20 cm. Visualization of lymphatic drainage on conventional images and images with the portable device were compared for number of nodes depicted, their intensity and localization of sentinel nodes. The images performed with the conventional gamma camera depicted sentinel nodes in 94%, while the portable gamma camera showed drainage in 73%. There was however no significant difference in visualization between the two devices when a lead shield was used to mask the injection area in 43 patients (95 vs 88%, p = 0.25). Second-echelon nodes were visualized in 62% of the patients with the conventional gamma camera and in 29% of the cases with the portable gamma camera. Preoperative imaging with a portable gamma camera fitted with a pinhole collimator to obtain a field of view of 20 x 20 cm is able to depict sentinel nodes in 88% of the cases, if a lead shield is used to mask the injection site. This device may be useful in centres without the possibility to perform a preoperative image. (orig.)

  8. The use of a portable gamma camera for preoperative lymphatic mapping: a comparison with a conventional gamma camera

    International Nuclear Information System (INIS)

    Vidal-Sicart, Sergi; Paredes, Pilar; Vermeeren, Lenka; Valdes-Olmos, Renato A.; Sola, Oriol

    2011-01-01

    Planar lymphoscintigraphy is routinely used for preoperative sentinel node visualization, but large gamma cameras are not always available. We evaluated the reproducibility of lymphatic mapping with a smaller and portable gamma camera. In two centres, 52 patients with breast cancer received preoperative lymphoscintigraphy with a conventional gamma camera with a field of view of 40 x 40 cm. Static anterior and lateral images were performed at 15 min, 2 h and 4 h after injection of the radiotracer ( 99m Tc-nanocolloid). At 2 h after injection, anterior and oblique images were also performed with a portable gamma camera (Sentinella, Oncovision) positioned to obtain a field of view of 20 x 20 cm. Visualization of lymphatic drainage on conventional images and images with the portable device were compared for number of nodes depicted, their intensity and localization of sentinel nodes. The images performed with the conventional gamma camera depicted sentinel nodes in 94%, while the portable gamma camera showed drainage in 73%. There was however no significant difference in visualization between the two devices when a lead shield was used to mask the injection area in 43 patients (95 vs 88%, p = 0.25). Second-echelon nodes were visualized in 62% of the patients with the conventional gamma camera and in 29% of the cases with the portable gamma camera. Preoperative imaging with a portable gamma camera fitted with a pinhole collimator to obtain a field of view of 20 x 20 cm is able to depict sentinel nodes in 88% of the cases, if a lead shield is used to mask the injection site. This device may be useful in centres without the possibility to perform a preoperative image. (orig.)

  9. Factors affecting the myocardial activity acquired during exercise SPECT with a high-sensitivity cardiac CZT camera as compared with conventional Anger camera

    International Nuclear Information System (INIS)

    Verger, Antoine; Karcher, Gilles; Imbert, Laetitia; Yagdigul, Yalcine; Roch, Veronique; Fay, Renaud; Djaballah, Wassila; Rouzet, Francois; Le Guludec, Dominique; Fourquet, Nicolas; Poussier, Sylvain; Marie, Pierre-Yves

    2014-01-01

    Injected doses are difficult to optimize for exercise SPECT since they depend on the myocardial fraction of injected activity (MFI) that is detected by the camera. The aim of this study was to analyse the factors affecting MFI determined using a cardiac CZT camera as compared with those determined using conventional Anger cameras. Factors affecting MFI were determined and compared in patients who had consecutive exercise SPECT acquisitions with 201 Tl (84 patients) or 99m Tc-sestamibi (87 patients) with an Anger or a CZT camera. A predictive model was validated in a group of patients routinely referred for 201 Tl (78 patients) or 99m Tc-sestamibi (80 patients) exercise CZT SPECT. The predictive model involved: (1) camera type, adjusted mean MFI being ninefold higher for CZT than for Anger SPECT, (2) tracer type, adjusted mean MFI being twofold higher for 201 Tl than for 99m Tc-sestamibi, and (3) logarithm of body weight. The CZT SPECT model led to a +1 ± 26 % error in the prediction of the actual MFI from the validation group. The mean MFI values estimated for CZT SPECT were more than twofold higher in patients with a body weight of 60 kg than in patients with a body weight of 120 kg (15.9 and 6.8 ppm for 99m Tc-sestamibi and 30.5 and 13.1ppm for 201 Tl, respectively), and for a 14-min acquisition of up to one million myocardial counts, the corresponding injected activities were only 80 and 186 MBq for 99m Tc-sestamibi and 39 and 91 MBq for 201 Tl, respectively. Myocardial activities acquired during exercise CZT SPECT are strongly influenced by body weight and tracer type, and are dramatically higher than those obtained using an Anger camera, allowing very low-dose protocols to be planned, especially for 99m Tc-sestamibi and in non-obese subjects. (orig.)

  10. PC-AT to gamma camera interface Anugami-S

    International Nuclear Information System (INIS)

    Bhattacharya, Sadhana; Sonalkar, S.Y.; Kataria, S.K.

    2000-01-01

    The gamma camera interface ANUGAMI-S is an image acquisition system used in nuclear medicine centres and hospitals. The state of the art design of the interface provides quality improvement in addition to image acquisition, by applying on-line uniformity correction which is very essential for gamma camera applications in nuclear medicine. The improvement in the quality of the image has been achieved by image acquisition in positionally varying and sliding energy window. It supports all acquisition modes viz. static, dynamic and gated acquisition modes with and without uniformity correction. The user interface provides the acquisition in various user selectable parameters with image display and related acquisition parameter display. It is a universal system which provides a modern, cost effective and easily maintainable solution for interfacing any gamma camera to PC or upgradation of analog gamma camera. The paper describes the system details and gated acquisition achieved on the present system. (author)

  11. Standardization of test conditions for gamma camera performance measurement

    International Nuclear Information System (INIS)

    Jordan, K.

    1982-02-01

    The way of measuring gamma camera performance is to use point sources or flood sources in air, often in combination with bar phantoms. This method has nothing in common with the use of a camera in clinical practice. Particularly in the case of low energy emitters, like Tc-99m, the influence of scattered radiation over the performance of cameras is very high. The IEC document 'Characteristics and test conditions of radionuclide imaging devices' is discussed

  12. Compact CdZnTe-Based Gamma Camera For Prostate Cancer Imaging

    International Nuclear Information System (INIS)

    Cui, Y.; Lall, T.; Tsui, B.; Yu, J.; Mahler, G.; Bolotnikov, A.; Vaska, P.; DeGeronimo, G.; O'Connor, P.; Meinken, G.; Joyal, J.; Barrett, J.; Camarda, G.; Hossain, A.; Kim, K.H.; Yang, G.; Pomper, M.; Cho, S.; Weisman, K.; Seo, Y.; Babich, J.; LaFrance, N.; James, R.B.

    2011-01-01

    In this paper, we discuss the design of a compact gamma camera for high-resolution prostate cancer imaging using Cadmium Zinc Telluride (CdZnTe or CZT) radiation detectors. Prostate cancer is a common disease in men. Nowadays, a blood test measuring the level of prostate specific antigen (PSA) is widely used for screening for the disease in males over 50, followed by (ultrasound) imaging-guided biopsy. However, PSA tests have a high false-positive rate and ultrasound-guided biopsy has a high likelihood of missing small cancerous tissues. Commercial methods of nuclear medical imaging, e.g. PET and SPECT, can functionally image the organs, and potentially find cancer tissues at early stages, but their applications in diagnosing prostate cancer has been limited by the smallness of the prostate gland and the long working distance between the organ and the detectors comprising these imaging systems. CZT is a semiconductor material with wide band-gap and relatively high electron mobility, and thus can operate at room temperature without additional cooling. CZT detectors are photon-electron direct-conversion devices, thus offering high energy-resolution in detecting gamma rays, enabling energy-resolved imaging, and reducing the background of Compton-scattering events. In addition, CZT material has high stopping power for gamma rays; for medical imaging, a few-mm-thick CZT material provides adequate detection efficiency for many SPECT radiotracers. Because of these advantages, CZT detectors are becoming popular for several SPECT medical-imaging applications. Most recently, we designed a compact gamma camera using CZT detectors coupled to an application-specific-integrated-circuit (ASIC). This camera functions as a trans-rectal probe to image the prostate gland from a distance of only 1-5 cm, thus offering higher detection efficiency and higher spatial resolution. Hence, it potentially can detect prostate cancers at their early stages. The performance tests of this camera

  13. Design and tests of a portable mini gamma camera

    International Nuclear Information System (INIS)

    Sanchez, F.; Benlloch, J.M.; Escat, B.; Pavon, N.; Porras, E.; Kadi-Hanifi, D.; Ruiz, J.A.; Mora, F.J.; Sebastia, A.

    2004-01-01

    Design optimization, manufacturing, and tests, both laboratory and clinical, of a portable gamma camera for medical applications are presented. This camera, based on a continuous scintillation crystal and a position-sensitive photomultiplier tube, has an intrinsic spatial resolution of ≅2 mm, an energy resolution of 13% at 140 keV, and linearities of 0.28 mm (absolute) and 0.15 mm (differential), with a useful field of view of 4.6 cm diameter. Our camera can image small organs with high efficiency and so it can address the demand for devices of specific clinical applications like thyroid and sentinel node scintigraphy as well as scintimammography and radio-guided surgery. The main advantages of the gamma camera with respect to those previously reported in the literature are high portability, low cost, and weight (2 kg), with no significant loss of sensitivity and spatial resolution. All the electronic components are packed inside the minigamma camera, and no external electronic devices are required. The camera is only connected through the universal serial bus port to a portable personal computer (PC), where a specific software allows to control both the camera parameters and the measuring process, by displaying on the PC the acquired image on 'real time'. In this article, we present the camera and describe the procedures that have led us to choose its configuration. Laboratory and clinical tests are presented together with diagnostic capabilities of the gamma camera

  14. Centering mount for a gamma camera

    International Nuclear Information System (INIS)

    Mirkhodzhaev, A.Kh.; Kuznetsov, N.K.; Ostryj, Yu.E.

    1988-01-01

    A device for centering a γ-camera detector in case of radionuclide diagnosis is described. It permits the use of available medical coaches instead of a table with a transparent top. The device can be used for centering a detector (when it is fixed at the low end of a γ-camera) on a required area of the patient's body

  15. PC-AT to gamma camera interface ANUGAMI-S

    International Nuclear Information System (INIS)

    Bhattacharya, Sadhana; Gopalakrishnan, K.R.

    1997-01-01

    PC-AT to gamma camera interface is an image acquisition system used in nuclear medicine centres and hospitals. The interface hardware and acquisition software have been designed and developed to meet most of the routine clinical applications using gamma camera. The state of the art design of the interface provides quality improvement in addition to image acquisition, by applying on-line uniformity correction which is very essential for gamma camera applications in nuclear medicine. The improvement in the quality of the image has been achieved by image acquisition in positionally varying and sliding energy window. It supports all acquisition modes viz. static, dynamic and gated acquisition modes with and without uniformity correction. The user interface provides the acquisition in various user selectable frame sizes, orientation and colour palettes. A complete emulation of camera console has been provided along with persistence scope and acquisition parameter display. It is a universal system which provides a modern, cost effective and easily maintainable solution for interfacing any gamma camera to PC or upgradation of analog gamma camera. (author). 4 refs., 3 figs

  16. Gamma camera based Positron Emission Tomography: a study of the viability on quantification

    International Nuclear Information System (INIS)

    Pozzo, Lorena

    2005-01-01

    Positron Emission Tomography (PET) is a Nuclear Medicine imaging modality for diagnostic purposes. Pharmaceuticals labeled with positron emitters are used and images which represent the in vivo biochemical process within tissues can be obtained. The positron/electron annihilation photons are detected in coincidence and this information is used for object reconstruction. Presently, there are two types of systems available for this imaging modality: the dedicated systems and those based on gamma camera technology. In this work, we utilized PET/SPECT systems, which also allows for the traditional Nuclear Medicine studies based on single photon emitters. There are inherent difficulties which affect quantification of activity and other indices. They are related to the Poisson nature of radioactivity, to radiation interactions with patient body and detector, noise due to statistical nature of these interactions and to all the detection processes, as well as the patient acquisition protocols. Corrections are described in the literature and not all of them are implemented by the manufacturers: scatter, attenuation, random, decay, dead time, spatial resolution, and others related to the properties of each equipment. The goal of this work was to assess these methods adopted by two manufacturers, as well as the influence of some technical characteristics of PET/SPECT systems on the estimation of SUV. Data from a set of phantoms were collected in 3D mode by one camera and 2D, by the other. We concluded that quantification is viable in PET/SPECT systems, including the estimation of SUVs. This is only possible if, apart from the above mentioned corrections, the camera is well tuned and coefficients for sensitivity normalization and partial volume corrections are applied. We also verified that the shapes of the sources used for obtaining these factors play a role on the final results and should be delt with carefully in clinical quantification. Finally, the choice of the region

  17. Spectroscopic gamma camera for use in high dose environments

    Energy Technology Data Exchange (ETDEWEB)

    Ueno, Yuichiro, E-mail: yuichiro.ueno.bv@hitachi.com [Research and Development Group, Hitachi, Ltd., Hitachi-shi, Ibaraki-ken 319-1221 (Japan); Takahashi, Isao; Ishitsu, Takafumi; Tadokoro, Takahiro; Okada, Koichi; Nagumo, Yasushi [Research and Development Group, Hitachi, Ltd., Hitachi-shi, Ibaraki-ken 319-1221 (Japan); Fujishima, Yasutake; Kometani, Yutaka [Hitachi Works, Hitachi-GE Nuclear Energy, Ltd., Hitachi-shi, Ibaraki-ken (Japan); Suzuki, Yasuhiko [Measuring Systems Engineering Dept., Hitachi Aloka Medical, Ltd., Ome-shi, Tokyo (Japan); Umegaki, Kikuo [Faculty of Engineering, Hokkaido University, Sapporo-shi, Hokkaido (Japan)

    2016-06-21

    We developed a pinhole gamma camera to measure distributions of radioactive material contaminants and to identify radionuclides in extraordinarily high dose regions (1000 mSv/h). The developed gamma camera is characterized by: (1) tolerance for high dose rate environments; (2) high spatial and spectral resolution for identifying unknown contaminating sources; and (3) good usability for being carried on a robot and remotely controlled. These are achieved by using a compact pixelated detector module with CdTe semiconductors, efficient shielding, and a fine resolution pinhole collimator. The gamma camera weighs less than 100 kg, and its field of view is an 8 m square in the case of a distance of 10 m and its image is divided into 256 (16×16) pixels. From the laboratory test, we found the energy resolution at the 662 keV photopeak was 2.3% FWHM, which is enough to identify the radionuclides. We found that the count rate per background dose rate was 220 cps h/mSv and the maximum count rate was 300 kcps, so the maximum dose rate of the environment where the gamma camera can be operated was calculated as 1400 mSv/h. We investigated the reactor building of Unit 1 at the Fukushima Dai-ichi Nuclear Power Plant using the gamma camera and could identify the unknown contaminating source in the dose rate environment that was as high as 659 mSv/h.

  18. Effect of scatter media on small gamma camera imaging characteristics

    International Nuclear Information System (INIS)

    Ser, H. K.; Choi, Y.; Yim, K. C.

    2001-01-01

    Effect of scatter media materials and thickness, located between radioactivity and small gamma camera, on imaging characteristics was evaluated. The small gamma camera developed for breast imaging was consisted of collimator, NaI(TI) crystal (60x60x6 mm 3 ). PSPMT (position sensitive photomultiplier tube), NIMs and personal computer. Monte Carlo simulation was performed to evaluate the system sensitivity with different scatter media thickness (0∼8 cm) and materials (air and acrylie) with parallel hole collimator and diverging collimator. The sensitivity and spatial resolution was measured using the small gamma camera with the same condition applied to the simulation. Counts was decreased by 10% (air) and 54% (acrylic) with the parallel hole collimator and by 35% (air) and 63% (acrylic) with the diverging collimator. Spatial resolution was decreased as increasing the thickness of scatter media. This study substantiate the importance of a gamma camera positioning and the minimization of the distance between detector and target lesion in the clinical application of a gamma camera

  19. Development and evaluation of a Gamma Camera tuning system

    International Nuclear Information System (INIS)

    Arista Romeu, E. J.; Diaz Garcia, A.; Osorio Deliz, J. F.

    2015-01-01

    Correct operation of conventional analogue Gamma Cameras implies a good conformation of the position signals that correspond to a specific photo-peak of the radionuclide of interest. In order to achieve this goal the energy spectrum from each photo multiplier tube (PMT) has to be set within the same energy window. For this reason a reliable tuning system is an important part of all gamma cameras processing systems. In this work is being tested and evaluated a new prototype of tuning card that was developed and setting up for this purpose. The hardware and software of the circuit allow the regulation if each PMT high voltage. By this means a proper gain control for each of them is accomplished. The Tuning Card prototype was simulated in a virtual model and its satisfactory operation was proven in a Siemens Orbiter Gamma Camera. (Author)

  20. Gamma camera image processing and graphical analysis mutual software system

    International Nuclear Information System (INIS)

    Wang Zhiqian; Chen Yongming; Ding Ailian; Ling Zhiye; Jin Yongjie

    1992-01-01

    GCCS gamma camera image processing and graphical analysis system is a special mutual software system. It is mainly used to analyse various patient data acquired from gamma camera. This system is used on IBM PC, PC/XT or PC/AT. It consists of several parts: system management, data management, device management, program package and user programs. The system provides two kinds of user interfaces: command menu and command characters. It is easy to change and enlarge this system because it is best modularized. The user programs include almost all the clinical protocols used now

  1. The clinical impact of a combined gamma camera/CT imaging system on somatostatin receptor imaging of neuroendocrine tumours

    International Nuclear Information System (INIS)

    Hillel, P.G.; Beek, E.J.R. van; Taylor, C.; Lorenz, E.; Bax, N.D.S.; Prakash, V.; Tindale, W.B.

    2006-01-01

    AIM: With a combined gamma camera/CT imaging system, CT images are obtained which are inherently registered to the emission images and can be used for the attenuation correction of SPECT and for mapping the functional information from these nuclear medicine tomograms onto anatomy. The aim of this study was to evaluate the clinical impact of SPECT/CT using such a system for somatostatin receptor imaging (SRI) of neuroendocrine tumours. MATERIALS AND METHODS: SPECT/CT imaging with 111 In-Pentetreotide was performed on 29 consecutive patients, the majority of whom had carcinoid disease. All SPECT images were first reported in isolation and then re-reported with the addition of the CT images for functional anatomical mapping (FAM). RESULTS: Fifteen of the 29 SPECT images were reported as abnormal, and in 11 of these abnormal images (73%) FAM was found to either establish a previously unknown location (7/11) or change the location (4/11) of at least one lesion. The revised location could be independently confirmed in 64% of these cases. Confirmation of location was not possible in the other patients due to either a lack of other relevant investigations, or the fact that lesions seen in the SPECT images were not apparent in the other investigations. FAM affected patient management in 64% of the cases where the additional anatomical information caused a change in the reported location of lesions. CONCLUSION: These results imply that FAM can improve the reporting accuracy for SPECT SRI with significant impact on patient management

  2. What about getting physiological information into dynamic gamma camera studies

    International Nuclear Information System (INIS)

    Kiuru, A.; Nickles, R. J.; Holden, J. E.; Polcyn, R. E.

    1976-01-01

    A general technique has been developed for the multiplexing of time dependent analog signals into the individual frames of a gamma camera dynamic function study. A pulse train, frequency-modulated by the physiological signal, is capacitively coupled to the preamplifier servicing anyone of the outer phototubes of the camera head. These negative tail pulses imitate photoevents occuring at a point outside of the camera field of view, chosen to occupy a data cell in an unused corner of the computer-stored square image. By defining a region of interest around this cell, the resulting time-activity curve displays the physiological variable in temporal synchrony with the radiotracer distribution. (author)

  3. A compact gamma camera for biological imaging

    Energy Technology Data Exchange (ETDEWEB)

    Bradley, E L; Cella, J; Majewski, S; Popov, V; Qian, Jianguo; Saha, M S; Smith, M F; Weisenberger, A G; Welsh, R E

    2006-02-01

    A compact detector, sized particularly for imaging a mouse, is described. The active area of the detector is approximately 46 mm; spl times/ 96 mm. Two flat-panel Hamamatsu H8500 position-sensitive photomultiplier tubes (PSPMTs) are coupled to a pixellated NaI(Tl) scintillator which views the animal through a copper-beryllium (CuBe) parallel-hole collimator specially designed for {sup 125}I. Although the PSPMTs have insensitive areas at their edges and there is a physical gap, corrections for scintillation light collection at the junction between the two tubes results in a uniform response across the entire rectangular area of the detector. The system described has been developed to optimize both sensitivity and resolution for in-vivo imaging of small animals injected with iodinated compounds. We demonstrate an in-vivo application of this detector, particularly to SPECT, by imaging mice injected with approximately 10-15; spl mu/Ci of {sup 125}I.

  4. Upgrade of the JET gamma-ray cameras

    International Nuclear Information System (INIS)

    Soare, S.; Curuia, M.; Anghel, M.; Constantin, M.; David, E.; Craciunescu, T.; Falie, D.; Pantea, A.; Tiseanu, I.; Kiptily, V.; Prior, P.; Edlington, T.; Griph, S.; Krivchenkov, Y.; Loughlin, M.; Popovichev, S.; Riccardo, V; Syme, B.; Thompson, V.; Lengar, I.; Murari, A.; Bonheure, G.; Le Guern, F.

    2007-01-01

    Full text: The JET gamma-ray camera diagnostics have already provided valuable information on the gamma-ray imaging of fast ion in JET plasmas. The applicability of gamma-ray imaging to high performance deuterium and deuterium-tritium JET discharges is strongly dependent on the fulfilment of rather strict requirements for the characterisation of the neutron and gamma-ray radiation fields. These requirements have to be satisfied within very stringent boundary conditions for the design, such as the requirement of minimum impact on the co-existing neutron camera diagnostics. The JET Gamma-Ray Cameras (GRC) upgrade project deals with these issues with particular emphasis on the design of appropriate neutron/gamma-ray filters ('neutron attenuators'). Several design versions have been developed and evaluated for the JET GRC neutron attenuators at the conceptual design level. The main design parameter was the neutron attenuation factor. The two design solutions, that have been finally chosen and developed at the level of scheme design, consist of: a) one quasi-crescent shaped neutron attenuator (for the horizontal camera) and b) two quasi-trapezoid shaped neutron attenuators (for the vertical one). The second design solution has different attenuation lengths: a short version, to be used together with the horizontal attenuator for deuterium discharges, and a long version to be used for high performance deuterium and DT discharges. Various neutron-attenuating materials have been considered (lithium hydride with natural isotopic composition and 6 Li enriched, light and heavy water, polyethylene). Pure light water was finally chosen as the attenuating material for the JET gamma-ray cameras. The neutron attenuators will be steered in and out of the detector line-of-sight by means of an electro-pneumatic steering and control system. The MCNP code was used for neutron and gamma ray transport in order to evaluate the effect of the neutron attenuators on the neutron field of the

  5. Factors affecting the myocardial activity acquired during exercise SPECT with a high-sensitivity cardiac CZT camera as compared with conventional Anger camera

    Energy Technology Data Exchange (ETDEWEB)

    Verger, Antoine; Karcher, Gilles [CHU-Nancy, Department of Nuclear Medicine, Nancy (France); INSERM U947 and Universite de Lorraine, Nancy (France); Nancyclotep experimental imaging platform, Nancy (France); Imbert, Laetitia [CHU-Nancy, Department of Nuclear Medicine, Nancy (France); Nancyclotep experimental imaging platform, Nancy (France); Centre Alexis Vautrin, Department of Radiotherapy, Vandoeuvre (France); Yagdigul, Yalcine; Roch, Veronique [CHU-Nancy, Department of Nuclear Medicine, Nancy (France); Nancyclotep experimental imaging platform, Nancy (France); Fay, Renaud [INSERM, Centre d' Investigation Clinique CIC-P 9501, Nancy (France); Djaballah, Wassila [CHU-Nancy, Department of Nuclear Medicine, Nancy (France); INSERM U947 and Universite de Lorraine, Nancy (France); Rouzet, Francois; Le Guludec, Dominique [AP-HP, Hopital Bichat, Department of Nuclear Medicine, Paris (France); INSERM U 773 and Denis Diderot University, Paris (France); Fourquet, Nicolas [Clinique Pasteur, Toulouse (France); Poussier, Sylvain [INSERM U947 and Universite de Lorraine, Nancy (France); Nancyclotep experimental imaging platform, Nancy (France); Marie, Pierre-Yves [CHU-Nancy, Department of Nuclear Medicine, Nancy (France); Nancyclotep experimental imaging platform, Nancy (France); INSERM U1116 and Universite de Lorraine, Nancy (France); CHU-Nancy, Allee du Morvan, Medecine Nucleaire, Hopital de Brabois, Vandoeuvre-les-Nancy (France)

    2014-03-15

    Injected doses are difficult to optimize for exercise SPECT since they depend on the myocardial fraction of injected activity (MFI) that is detected by the camera. The aim of this study was to analyse the factors affecting MFI determined using a cardiac CZT camera as compared with those determined using conventional Anger cameras. Factors affecting MFI were determined and compared in patients who had consecutive exercise SPECT acquisitions with {sup 201}Tl (84 patients) or {sup 99m}Tc-sestamibi (87 patients) with an Anger or a CZT camera. A predictive model was validated in a group of patients routinely referred for {sup 201}Tl (78 patients) or {sup 99m}Tc-sestamibi (80 patients) exercise CZT SPECT. The predictive model involved: (1) camera type, adjusted mean MFI being ninefold higher for CZT than for Anger SPECT, (2) tracer type, adjusted mean MFI being twofold higher for {sup 201}Tl than for {sup 99m}Tc-sestamibi, and (3) logarithm of body weight. The CZT SPECT model led to a +1 ± 26 % error in the prediction of the actual MFI from the validation group. The mean MFI values estimated for CZT SPECT were more than twofold higher in patients with a body weight of 60 kg than in patients with a body weight of 120 kg (15.9 and 6.8 ppm for {sup 99m}Tc-sestamibi and 30.5 and 13.1ppm for {sup 201}Tl, respectively), and for a 14-min acquisition of up to one million myocardial counts, the corresponding injected activities were only 80 and 186 MBq for {sup 99m}Tc-sestamibi and 39 and 91 MBq for {sup 201}Tl, respectively. Myocardial activities acquired during exercise CZT SPECT are strongly influenced by body weight and tracer type, and are dramatically higher than those obtained using an Anger camera, allowing very low-dose protocols to be planned, especially for {sup 99m}Tc-sestamibi and in non-obese subjects. (orig.)

  6. The effect of Compton scattering on quantitative SPECT imaging

    International Nuclear Information System (INIS)

    Beck, J.W.; Jaszczak, R.J.; Starmer, C.F.

    1982-01-01

    A Monte Carlo code has been developed to simulate the response of a SPECT system. The accuracy of the code has been verified and has been used in this research to study and illustrate the effects of Compton scatter on quantitative SPECT measurements. The effects of Compton scattered radiation on gamma camera response have been discussed by several authors, and will be extended to rotating gamma camera SPECT systems. The unique feature of this research includes the pictorial illustration of the Compton scattered and the unscattered components of the photopeak data on SPECT imaging by simulating phantom studies with and without Compton scatter

  7. Programmable electronic system for analog and digital gamma cameras modernization

    International Nuclear Information System (INIS)

    Osorio Deliz, J. F.; Diaz Garcia, A.; Arista Omeu, E. J.

    2013-01-01

    At present the use of analog and digital gamma cameras is continuously increasing in developing countries. Many of them still largely rely in old hardware electronics, which in many cases limits their use in actual nuclear medicine diagnostic studies. For this reason worldwide there are different medical equipment manufacturing companies engaged into partial or total Gamma Cameras modernization. Nevertheless in several occasions acquisition prices are not affordable for developing countries. This work describes the basic features of a programmable electronic system that allows improving acquisitions functions and processing of analog and digital gamma cameras. This system is based on an electronic board for the acquisition and digitization of nuclear pulses which have been generated by gamma camera detector. It comprises a hardware interface with PC and the associated software to fully signal processing. Signal shaping and image processing are included. The extensive use of reference tables in the processing and signal imaging software allowed the optimization of the processing speed. Time design and system cost were also decreased. (Author)

  8. The current status of SPECT or SPECT/CT in South Korea

    Energy Technology Data Exchange (ETDEWEB)

    Yoo, Ik Dong; Choi, Eun Kyung; Chung, Yong An [Dept. of Radiology, Incheon Saint Mary' s HospitalThe Catholic University of Korea, Incheon (Korea, Republic of)

    2017-06-15

    The first step to nuclear medicine in Korea started with introduction of the gamma camera in 1969. Although planar images with the gamma camera give important functional information, they have the limitations that result from 2-dimensional images. Single-photon emission computed tomography (SPECT) due to its 3-dimensional image acquisition is superior to earlier planar gamma imaging in image resolution and diagnostic accuracy. As demand for a hybrid functional and anatomical imaging device has increased, integrated SPECT/CT systems have been used. In Korea, SPECT/CT was for the first time installed in 2003. SPECT/CT can eliminate many possible pitfalls on SPECT-alone images, making better attenuation correction and thereby improving image quality. Therefore, SPECT/CT is clinically preferred in many hospitals in various aspects. More recently, additional SPECT/CT images taken from the region with equivocal uptake on planar images have been helpful in making precise interpretation as part of their clinical workup in postoperative thyroid cancer patients. SPECT and SPECT/CT have various advantages, but its clinical application has gradually decreased in recent few years. While some researchers investigated the myocardial blood flow with cardiac PET using F-18 FDG or N-13 ammonia, myocardial perfusion SPECT is, at present, the radionuclide imaging study of choice for the risk stratification and guiding therapy in the coronary artery disease patients in Korea. New diagnostic radiopharmaceuticals for AD have received increasing attention; nevertheless, brain SPECT will remain the most reliable modality evaluating cerebral perfusion.

  9. Intraoperative radioguidance with a portable gamma camera: a novel technique for laparoscopic sentinel node localisation in urological malignancies

    International Nuclear Information System (INIS)

    Vermeeren, L.; Valdes Olmos, R.A.; Vogel, W.V.; Sivro, F.; Hoefnagel, C.A.; Meinhardt, W.; Bex, A.; Poel, H.G. van der; Horenblas, S.

    2009-01-01

    Our aim was to assess the feasibility of intraoperative radioguidance with a portable gamma camera during laparoscopic sentinel node (SN) procedures in urological malignancies. We evaluated the use of the intraoperative portable gamma camera in 20 patients: 16 patients with prostate carcinoma (PCC), 2 patients with renal cell carcinoma (RC) and 2 patients with testicular cancer (TC). Intra/peritumoural injection of 99m Tc-nanocolloid ( 99m Tc) was followed by planar lymphoscintigraphy, SPECT/CT and marking of SN levels. Before laparoscopy a 125 I seed was fixed on the laparoscopic gamma probe as a pointer of SN seeking. The portable gamma camera was set to display the 99m Tc signal for SN localisation and the 125 I signal for SN seeking. Matching of these signals on screen indicated exact SN localisation, and consequently this SN was removed. The mean injected dose was 218 MBq in PCC, 228 MBq in RC and 88 MBq in TC. Pelvic SN were visualised in all PCC patients, with uncommonly located SN in seven patients. SN metastases were found in seven patients (one in a uncommonly located SN). Both RC patients and TC patients had para-aortic SN, which were all tumour free. A total of 59 SN were removed. The portable gamma camera enabled real-time SN display/identification in 18 patients (90%). The use of a portable gamma camera in combination with a laparoscopic gamma probe incorporates intraoperative real-time imaging with improved SN identification in urological malignancies. This procedure might also be useful for SN identification of other deep draining malignancies. (orig.)

  10. Intraoperative radioguidance with a portable gamma camera: a novel technique for laparoscopic sentinel node localisation in urological malignancies

    Energy Technology Data Exchange (ETDEWEB)

    Vermeeren, L.; Valdes Olmos, R.A.; Vogel, W.V.; Sivro, F.; Hoefnagel, C.A. [Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Department of Nuclear Medicine, Amsterdam (Netherlands); Meinhardt, W.; Bex, A.; Poel, H.G. van der; Horenblas, S. [Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Department of Urology, Amsterdam (Netherlands)

    2009-07-15

    Our aim was to assess the feasibility of intraoperative radioguidance with a portable gamma camera during laparoscopic sentinel node (SN) procedures in urological malignancies. We evaluated the use of the intraoperative portable gamma camera in 20 patients: 16 patients with prostate carcinoma (PCC), 2 patients with renal cell carcinoma (RC) and 2 patients with testicular cancer (TC). Intra/peritumoural injection of {sup 99m}Tc-nanocolloid ({sup 99m}Tc) was followed by planar lymphoscintigraphy, SPECT/CT and marking of SN levels. Before laparoscopy a {sup 125}I seed was fixed on the laparoscopic gamma probe as a pointer of SN seeking. The portable gamma camera was set to display the {sup 99m}Tc signal for SN localisation and the {sup 125}I signal for SN seeking. Matching of these signals on screen indicated exact SN localisation, and consequently this SN was removed. The mean injected dose was 218 MBq in PCC, 228 MBq in RC and 88 MBq in TC. Pelvic SN were visualised in all PCC patients, with uncommonly located SN in seven patients. SN metastases were found in seven patients (one in a uncommonly located SN). Both RC patients and TC patients had para-aortic SN, which were all tumour free. A total of 59 SN were removed. The portable gamma camera enabled real-time SN display/identification in 18 patients (90%). The use of a portable gamma camera in combination with a laparoscopic gamma probe incorporates intraoperative real-time imaging with improved SN identification in urological malignancies. This procedure might also be useful for SN identification of other deep draining malignancies. (orig.)

  11. Miniature gamma-ray camera for tumor localization

    International Nuclear Information System (INIS)

    Lund, J.C.; Olsen, R.W.; James, R.B.; Cross, E.

    1997-08-01

    The overall goal of this LDRD project was to develop technology for a miniature gamma-ray camera for use in nuclear medicine. The camera will meet a need of the medical community for an improved means to image radio-pharmaceuticals in the body. In addition, this technology-with only slight modifications-should prove useful in applications requiring the monitoring and verification of special nuclear materials (SNMs). Utilization of the good energy resolution of mercuric iodide and cadmium zinc telluride detectors provides a means for rejecting scattered gamma-rays and improving the isotopic selectivity in gamma-ray images. The first year of this project involved fabrication and testing of a monolithic mercuric iodide and cadmium zinc telluride detector arrays and appropriate collimators/apertures. The second year of the program involved integration of the front-end detector module, pulse processing electronics, computer, software, and display

  12. Development of the set of corrections for a gamma camera dedicated to research; Desarrollo del conjunto de correcciones para una gammacamara dedicada a investigacion

    Energy Technology Data Exchange (ETDEWEB)

    Gimenez Insua, M.; Ambroa Rey, E. M.; Vazquez Vazquez, R.; Sanchez Garcia, M.; Luna Vega, V.; Mosquera Sueiro, J.; Otero Martinez, C.; Lobato Busto, R.; Pombar Camean, M.

    2013-07-01

    As part of a project for animal research, replaced electronics one of the gamma-cameras (GC) of the service that was out of use, with the aim of using it for SPECT. The implementation is therefore required of the corrections that allow image quality enough for SPECT from raw data supplied by the team. This has been developed software that enables to perform correction of power, uniform and linearity on the acquired data. For validation, change in several parameters indicative of the image quality has been evaluated. (Author)

  13. Optimization of gamma-ray cameras of Anger type

    International Nuclear Information System (INIS)

    Jatteau, Michel; Lelong, Pierre; Normand, Gerard; Ott, Jean; Pauvert, Joseph; Pergrale, Jean

    1979-01-01

    Most of the radionuclide imaging equipments used for the diagnosis in nuclear medicine include a scintillation camera of the Anger type. Following a period of camera improvements connected to pure technological advances, perfecting the camera can only result nowadays from more thorough studies based on numerical approaches and computer simulations. Two important contributions to an optimization study of Anger gamma-ray cameras are presented, the first one being related to the light collection by the photomultiplier tubes, i.e. one of the processes which determine for a large part the performance parameters; the second one being connected to the computation of the intrinsic geometrical and spectral resolutions, which are two of the main characteristics acting on the image quality. The validity of computer simulation is shown by comparison between theoretical and experimental results before the simulation programmes to study the influence of various parameters are used [fr

  14. Standardization of test conditions for gamma camera performance measurement

    International Nuclear Information System (INIS)

    Jordan, K.

    1980-01-01

    The actual way of measuring gamma camera performance is to use point sources or flood sources in air, often in combination with bar phantoms. This method mostly brings best performance parameters for cameras but it has nothing in common with the use of a camera in clinical practice. Particular in the case of low energy emitters, like Tc-99m, the influence of scattered radiation over the performance of cameras is very high. Therefore it is important to have test conditions of radionuclide imaging devices, that will approach as best as practicable the measuring conditions in clinical applications. It is therefore a good news that the International Electrochemical Commission IEC has prepared a draft 'Characteristics and test conditions of radionuclide imaging devices' which is now submitted to the national committees for formal approval under the Six Months' Rule. Some essential points of this document are discussed in the paper. (orig.) [de

  15. The use of a Micromegas as a detector for gamma camera

    International Nuclear Information System (INIS)

    Barbouchi, Asma; Trabelsi, Adel

    2008-01-01

    The micromegas (Micro Mesh Gaseaous) is a gas detector; it was developed by I.Giomattaris and G.Charpak for application in the field of experimental particle physics. But the polyvalence of this detector makes it to be used in several areas such as medical imaging. This detector has an X-Y readout capability of resolution less than 100μm, an energy resolution down to 14% for energy range 1-10 keV and an overall efficiency of 70%. Monte carlo simulation is widely used in nuclear medicine. It allows predicting the behaviour of system. Gate (Geant4 for Application Tomography Emission) is a platform for monte carlo simulation. It is dedicated to PET/SPECT (Position Emission Tomography / single Photon Emission Tomography) applications. Our goal is to model a gamma camera that use a Micromegas as a detector and to compare their performances (energy resolution, point spread function...) with those of a scintillated gamma camera by using Gate

  16. The effect of acquisition interval and spatial resolution on dynamic cardiac imaging with a stationary SPECT camera

    International Nuclear Information System (INIS)

    Roberts, J; Maddula, R; Clackdoyle, R; DiBella, E; Fu, Z

    2007-01-01

    The current SPECT scanning paradigm that acquires images by slow rotation of multiple detectors in body-contoured orbits around the patient is not suited to the rapid collection of tomographically complete data. During rapid image acquisition, mechanical and patient safety constraints limit the detector orbit to circular paths at increased distances from the patient, resulting in decreased spatial resolution. We consider a novel dynamic rotating slant-hole (DyRoSH) SPECT camera that can collect full tomographic data every 2 s, employing three stationary detectors mounted with slant-hole collimators that rotate at 30 rpm. Because the detectors are stationary, they can be placed much closer to the patient than is possible with conventional SPECT systems. We propose that the decoupling of the detector position from the mechanics of rapid image acquisition offers an additional degree of freedom which can be used to improve accuracy in measured kinetic parameter estimates. With simulations and list-mode reconstructions, we consider the effects of different acquisition intervals on dynamic cardiac imaging, comparing a conventional three detector SPECT system with the proposed DyRoSH SPECT system. Kinetic parameters of a two-compartment model of myocardial perfusion for technetium-99m-teboroxime were estimated. When compared to a conventional SPECT scanner for the same acquisition periods, the proposed DyRoSH system shows equivalent or reduced bias or standard deviation values for the kinetic parameter estimates. The DyRoSH camera with a 2 s acquisition period does not show any improvement compared to a DyRoSH camera with a 10 s acquisition period

  17. The effect of acquisition interval and spatial resolution on dynamic cardiac imaging with a stationary SPECT camera

    Science.gov (United States)

    Roberts, J.; Maddula, R.; Clackdoyle, R.; Di Bella, E.; Fu, Z.

    2007-08-01

    The current SPECT scanning paradigm that acquires images by slow rotation of multiple detectors in body-contoured orbits around the patient is not suited to the rapid collection of tomographically complete data. During rapid image acquisition, mechanical and patient safety constraints limit the detector orbit to circular paths at increased distances from the patient, resulting in decreased spatial resolution. We consider a novel dynamic rotating slant-hole (DyRoSH) SPECT camera that can collect full tomographic data every 2 s, employing three stationary detectors mounted with slant-hole collimators that rotate at 30 rpm. Because the detectors are stationary, they can be placed much closer to the patient than is possible with conventional SPECT systems. We propose that the decoupling of the detector position from the mechanics of rapid image acquisition offers an additional degree of freedom which can be used to improve accuracy in measured kinetic parameter estimates. With simulations and list-mode reconstructions, we consider the effects of different acquisition intervals on dynamic cardiac imaging, comparing a conventional three detector SPECT system with the proposed DyRoSH SPECT system. Kinetic parameters of a two-compartment model of myocardial perfusion for technetium-99m-teboroxime were estimated. When compared to a conventional SPECT scanner for the same acquisition periods, the proposed DyRoSH system shows equivalent or reduced bias or standard deviation values for the kinetic parameter estimates. The DyRoSH camera with a 2 s acquisition period does not show any improvement compared to a DyRoSH camera with a 10 s acquisition period.

  18. Sci—Thur PM: Imaging — 05: Calibration of a SPECT/CT camera for quantitative SPECT with 99mTc

    International Nuclear Information System (INIS)

    Gaudin, Émilie; Montégiani, Jean-François; Després, Philippe; Beauregard, Jean-Mathieu

    2014-01-01

    While quantitation is the norm in PET, it is not widely available yet in SPECT. This work's aim was to calibrate a commercially available SPECT/CT system to perform quantitative SPECT. Counting sensitivity, dead-time (DT) constant and partial volume effect (PVE) of the system were assessed. A dual-head Siemens SymbiaT6 SPECT/CT camera equipped with low energy high-resolution collimators was studied. 99m Tc was the radioisotope of interest because of its wide usage in nuclear medicine. First, point source acquisitions were performed (activity: 30–990MBq). Further acquisitions were then performed with a uniform Jaszczak phantom filled with water at high activity (25–5000MBq). PVE was studied using 6 hot spheres (diameters: 9.9–31.2 mm) filled with 99m Tc (2.8MBq/cc) in the Jaszczak phantom, which was: (1) empty, (2) water-filled and (3) water-filled with low activity (0.1MBq/cc). The data was reconstructed with the Siemens's Flash3D iterative algorithm with 4 subsets and 8 iterations, attenuation-correction (AC) and scatter-correction (SC). DT modelling was based on the total spectrum counting rate. Sensitivity was assessed using AC-SC reconstructed SPECT data. Sensitivity and DT for the sources were 99.51±1.46cps/MBq and 0.60±0.04µs. For the phantom, sensitivity and DT were 109.9±2.3cps/MBq and 0.62±0.13µs. The recovery-coefficient varied from 5% for the 9.9mm, to 80% for the 31.2mm spheres. With our calibration methods, both sensitivity and DT constant of the SPECT camera had little dependence on the object geometry and attenuation. For small objects of known size, recovery-coefficient can be applied to correct PVE. Clinical quantitative SPECT appears to be possible and has many potential applications

  19. Reading and comparative quantification of perfusion myocardium tomo-scintigraphy realised by gamma camera and semiconductors camera

    International Nuclear Information System (INIS)

    Merlin, C.; Gauthe, M.; Bertrand, S.; Kelly, A.; Veyre, A.; Mestas, D.; Cachin, F.; Motreff, P.

    2010-01-01

    By offering high quality images, semiconductor cameras represent an undeniable technological progress. The interpretation of examinations, however, requires a learning phase. The optimization of quantification software should confirm the superiority of the D-SPECT for the measurement of kinetic parameters. (N.C.)

  20. Performance characteristics of ZLC 37 Siemens gamma camera

    Energy Technology Data Exchange (ETDEWEB)

    Abdelgadir, Wafaa Abdelrahman [Department of Physics, Faculty of Science, University of Khartoum, Khartoum (Sudan)

    1994-04-01

    The relationships between the ZLC 37 Siemens {gamma} camera parameters (energy resolution, plane sensitivity, intrinsic uniformity, intrinsic resolution, system uniformity and system resolution) and diagnostic imaging performance was investigated. These parameters when computers when compared with internationally published data showed that the ZLC 37 Siemens {gamma} cameras is in good operative conditions. The effect of the scattering media and WW on the spatial resolution, when the distance is kept fixed were investigated. Comparison of resolution for the media (air, water, water + radioactivity) when using WW (10, 15,20%) showed that the resolution is best for air, better for water and worse for water + radioactivity up to a concentration of 8% for a 10% WW. (Author) 28 refs. , 10 tabs. , 22 figs. Also available from the Department of Physics, Faculty of Science, University of Khartoum, Khartoum (SD)

  1. Gamma camera investigations using an on-line computer system

    International Nuclear Information System (INIS)

    Vikterloef, K.J.; Beckman, K.-W.; Berne, E.; Liljenfors, B.

    1974-01-01

    A computer system for use with a gamma camera has been developed by Oerebro Regional Hospital and Nukab AB using a PDP 8/e with a 12K core memory connected to a Selektronik gamma camera. It is possible to register, without loss, pictures of high (5kcps) pulse frequency, two separate channels with identical coordinates, fast dynamic functions down to 5 pictures/second, and to perform statistical smoothing and subtraction of two separate pictures. Experience has shown these possibilities to be so valuable that one has difficulty in thinking of a scanning system without them. This applies not only to sophisticated investigations, e.g. dual isotope registration, but also in conventional scanning for avoiding false positive interpretations and increasing the precision. It is possible at relatively low cost to add a dosage planning system. (JIW)

  2. Acquisition of gamma camera and physiological data by computer

    International Nuclear Information System (INIS)

    Hack, S.N.; Chang, M.; Line, B.R.; Cooper, J.A.; Robeson, G.H.

    1986-01-01

    We have designed, implemented, and tested a new Research Data Acquisition System (RDAS) that permits a general purpose digital computer to acquire signals from both gamma camera sources and physiological signal sources concurrently. This system overcomes the limited multi-source, high speed data acquisition capabilities found in most clinically oriented nuclear medicine computers. The RDAS can simultaneously input signals from up to four gamma camera sources with a throughput of 200 kHz per source and from up to eight physiological signal sources with an aggregate throughput of 50 kHz. Rigorous testing has found the RDAS to exhibit acceptable linearity and timing characteristics. In addition, flood images obtained by this system were compared with flood images acquired by a commercial nuclear medicine computer system. National Electrical Manufacturers Association performance standards of the flood images were found to be comparable

  3. Evaluation of efficiency of a semiconductor gamma camera

    CERN Document Server

    Otake, H; Takeuchi, Y

    2002-01-01

    We evaluation basic characteristics of a compact type semiconductor gamma camera (eZ-SCOPE AN) of Cadmium Zinc Telluride (CdZnTe). This new compact gamma camera has 256 semiconductors representing the same number of pixels. Each semiconductor is 2 mm square and is located in 16 lines and rows on the surface of the detector. The specific performance characteristics were evaluated in the study referring to National Electrical Manufactures Association (NEMA) standards; intrinsic energy resolution, intrinsic count rate performance, integral uniformity, system planar sensitivity, system spatial resolution, and noise to the neighboring pixels. The intrinsic energy resolution measured 5.7% as full width half maximum (FWHM). The intrinsic count rate performance ranging from 17 kcps to 1,285 kcps was evaluated, but the highest intrinsic count rate was not observed. Twenty percents count loss was recognized at 1,021 kcps. The integral uniformity was 1.3% with high sensitivity collimator. The system planar sensitivity w...

  4. Rapid objective measurement of gamma camera resolution using statistical moments.

    Science.gov (United States)

    Hander, T A; Lancaster, J L; Kopp, D T; Lasher, J C; Blumhardt, R; Fox, P T

    1997-02-01

    An easy and rapid method for the measurement of the intrinsic spatial resolution of a gamma camera was developed. The measurement is based on the first and second statistical moments of regions of interest (ROIs) applied to bar phantom images. This leads to an estimate of the modulation transfer function (MTF) and the full-width-at-half-maximum (FWHM) of a line spread function (LSF). Bar phantom images were acquired using four large field-of-view (LFOV) gamma cameras (Scintronix, Picker, Searle, Siemens). The following factors important for routine measurements of gamma camera resolution with this method were tested: ROI placement and shape, phantom orientation, spatial sampling, and procedural consistency. A 0.2% coefficient of variation (CV) between repeat measurements of MTF was observed for a circular ROI. The CVs of less than 2% were observed for measured MTF values for bar orientations ranging from -10 degrees to +10 degrees with respect to the x and y axes of the camera acquisition matrix. A 256 x 256 matrix (1.6 mm pixel spacing) was judged sufficient for routine measurements, giving an estimate of the FWHM to within 0.1 mm of manufacturer-specified values (3% difference). Under simulated clinical conditions, the variation in measurements attributable to procedural effects yielded a CV of less than 2% in newer generation cameras. The moments method for determining MTF correlated well with a peak-valley method, with an average difference of 0.03 across the range of spatial frequencies tested (0.11-0.17 line pairs/mm, corresponding to 4.5-3.0 mm bars). When compared with the NEMA method for measuring intrinsic spatial resolution, the moments method was found to be within 4% of the expected FWHM.

  5. Is it practical to use the gamma camera dead time

    International Nuclear Information System (INIS)

    Morin, P.P.; Morin, J.F.; Caroff, J.; Lahellec, M.; Savina, A.

    1975-01-01

    The linearity of gamma camera counting is an essential feature for users engaged in quantitative dynamic studies. Instead of defining this quality by the usual dead time, the disadvantages of which are reported, it is proposed to use the experimental count rate giving 10% loss. It is shown that by proceeding in this way all ambiguity would be abolished, where both the counting linearity itself and its relation to sensitivity are concerned [fr

  6. Biomedical image acquisition system using a gamma camera

    International Nuclear Information System (INIS)

    Jara B, A.T.; Sevillano, J.; Del Carpio S, J.A.

    2003-01-01

    A gamma camera images PC acquisition board has been developed. The digital system has been described using VHDL and has been synthesized and implemented in a Altera Max7128S CPLD and two PALs 16L8. The use of programmable-logic technologies has afforded a higher scale integration and a reduction of the digital delays and also has allowed us to modify and bring up to date the entire digital design easily. (orig.)

  7. Impact of intense x-ray pulses on a NaI(Tl)-based gamma camera

    Science.gov (United States)

    Koppert, W. J. C.; van der Velden, S.; Steenbergen, J. H. L.; de Jong, H. W. A. M.

    2018-03-01

    In SPECT/CT systems x-ray and γ-ray imaging is performed sequentially. Simultaneous acquisition may have advantages, for instance in interventional settings. However, this may expose a gamma camera to relatively high x-ray doses and deteriorate its functioning. We studied the NaI(Tl) response to x-ray pulses with a photodiode, PMT and gamma camera, respectively. First, we exposed a NaI(Tl)-photodiode assembly to x-ray pulses to investigate potential crystal afterglow. Next, we exposed a NaI(Tl)-PMT assembly to 10 ms LED pulses (mimicking x-ray pulses) and measured the response to flashing LED probe-pulses (mimicking γ-pulses). We then exposed the assembly to x-ray pulses, with detector entrance doses of up to 9 nGy/pulse, and analysed the response for γ-pulse variations. Finally, we studied the response of a Siemens Diacam gamma camera to γ-rays while exposed to x-ray pulses. X-ray exposure of the crystal, read out with a photodiode, revealed 15% afterglow fraction after 3 ms. The NaI(Tl)-PMT assembly showed disturbances up to 10 ms after 10 ms LED exposure. After x-ray exposure however, responses showed elevated baselines, with 60 ms decay-time. Both for x-ray and LED exposure and after baseline subtraction, probe-pulse analysis revealed disturbed pulse height measurements shortly after exposure. X-ray exposure of the Diacam corroborated the elementary experiments. Up to 50 ms after an x-ray pulse, no events are registered, followed by apparent energy elevations up to 100 ms after exposure. Limiting the dose to 0.02 nGy/pulse prevents detrimental effects. Conventional gamma cameras exhibit substantial dead-time and mis-registration of photon energies up to 100 ms after intense x-ray pulses. This is due PMT limitations and due to afterglow in the crystal. Using PMTs with modified circuitry, we show that deteriorative afterglow effects can be reduced without noticeable effects on the PMT performance, up to x-ray pulse doses of 1 nGy.

  8. A flexible geometry Compton camera for industrial gamma ray imaging

    International Nuclear Information System (INIS)

    Royle, G.J.; Speller, R.D.

    1996-01-01

    A design for a Compton scatter camera is proposed which is applicable to gamma ray imaging within limited access industrial sites. The camera consists of a number of single element detectors arranged in a small cluster. Coincidence circuitry enables the detectors to act as a scatter camera. Positioning the detector cluster at various locations within the site, and subsequent reconstruction of the recorded data, allows an image to be obtained. The camera design allows flexibility to cater for limited space or access simply by positioning the detectors in the optimum geometric arrangement within the space allowed. The quality of the image will be limited but imaging could still be achieved in regions which are otherwise inaccessible. Computer simulation algorithms have been written to optimize the various parameters involved, such as geometrical arrangement of the detector cluster and the positioning of the cluster within the site, and to estimate the performance of such a device. Both scintillator and semiconductor detectors have been studied. A prototype camera has been constructed which operates three small single element detectors in coincidence. It has been tested in a laboratory simulation of an industrial site. This consisted of a small room (2 m wide x 1 m deep x 2 m high) into which the only access points were two 6 cm diameter holes in a side wall. Simple images of Cs-137 sources have been produced. The work described has been done on behalf of BNFL for applications at their Sellafield reprocessing plant in the UK

  9. SiPM-MAROC gamma-camera prototype with monolithic NaI(Tl) scintillator

    Energy Technology Data Exchange (ETDEWEB)

    Philippov, Dmitry; Ilyin, Andrey; Belyaev, Vladimir; Popova, Elan [National Research Nuclear University, Moscow Engineering Physics Institute (Russian Federation); Buzhan, Pavel; Stifutkin, Alexei [Moscow Engineering Physics Institute (Russian Federation)

    2015-05-18

    A full-body gamma-camera based on SiPM readout is currently under development as a part of MEPHI R activity supported in the framework of Russian Megagrants program. A goal of this development is a fast upgrade of existing medical equipment with minor changes in a system design and construction in order to combine SPECT and MR instruments. A monolithic NaI(Tl) scintillator commonly used for conventional PMT-based gamma cameras has been chosen for this study. SiPMs will be coupled with the scintillator via an optical guide. To cover scintillator surface thousands of SiPMs are required, together with multichannel front-end electronics. That means that readout electronics have to be very compact, with low power consumption and low cost. 64 – channel ASIC MAROC from Weeroc provides individual readout of each SiPM and has been considered as the best choice among electronics solutions available on the market. As the photodetector parameters are the key issues here, KETEK SiPMs with high detection efficiency, low crosstalk and low noise have been chosen for this study. In order to study the proposed detection system in detail and obtain detector module parameters, required for MC simulation, a 64-channel small prototype with 6x6mm{sup 2} SiPMs has been constructed and tested. SiPMs in SMD packages have been assembled as a matrix of 8x8 elements and readout by MAROC-based board. Prototype has been tested with different shape NaI(Tl) scintillators and gammas with different energy. Dedicated algorithms for extraction of gamma-event’s energy and position are under development. They are based on fitting a matrix of individual SiPMs responses by an analytical function F(x,y). They will be tested with GEANT-simulated events and experimental data. Development of the next (engineering) prototype of SiPM’s module for gamma-camera will be started soon.

  10. SiPM-MAROC gamma-camera prototype with monolithic NaI(Tl) scintillator

    International Nuclear Information System (INIS)

    Philippov, Dmitry; Ilyin, Andrey; Belyaev, Vladimir; Popova, Elan; Buzhan, Pavel; Stifutkin, Alexei

    2015-01-01

    A full-body gamma-camera based on SiPM readout is currently under development as a part of MEPHI R activity supported in the framework of Russian Megagrants program. A goal of this development is a fast upgrade of existing medical equipment with minor changes in a system design and construction in order to combine SPECT and MR instruments. A monolithic NaI(Tl) scintillator commonly used for conventional PMT-based gamma cameras has been chosen for this study. SiPMs will be coupled with the scintillator via an optical guide. To cover scintillator surface thousands of SiPMs are required, together with multichannel front-end electronics. That means that readout electronics have to be very compact, with low power consumption and low cost. 64 – channel ASIC MAROC from Weeroc provides individual readout of each SiPM and has been considered as the best choice among electronics solutions available on the market. As the photodetector parameters are the key issues here, KETEK SiPMs with high detection efficiency, low crosstalk and low noise have been chosen for this study. In order to study the proposed detection system in detail and obtain detector module parameters, required for MC simulation, a 64-channel small prototype with 6x6mm 2 SiPMs has been constructed and tested. SiPMs in SMD packages have been assembled as a matrix of 8x8 elements and readout by MAROC-based board. Prototype has been tested with different shape NaI(Tl) scintillators and gammas with different energy. Dedicated algorithms for extraction of gamma-event’s energy and position are under development. They are based on fitting a matrix of individual SiPMs responses by an analytical function F(x,y). They will be tested with GEANT-simulated events and experimental data. Development of the next (engineering) prototype of SiPM’s module for gamma-camera will be started soon.

  11. Effects of use of the lodine contrast medium on gamma camera imaging

    Energy Technology Data Exchange (ETDEWEB)

    Pyo, Sung Jae; Cho, Yun Ho [Dept. of Nuclear Medicine, Inha University hospital, Incheon (Korea, Republic of); Choi, Jae Ho [Dept. of Radiological Technology, Ansan College, Ansan (Korea, Republic of)

    2016-12-15

    Effects of Gamma camera imaging on gamma ray counting rates as a function of use and density of the iodine contrast medium currently in primary use for clinics, and changes in gamma ray counting rates as a function of the contrast medium status upon attenuation correction using a CT absorption coefficientin an SPECT/CT attenuation correction will be considered herein. For experimental materials used 99mTcO4 370 MBq and Pamiray 370 mg, Iomeron 350 mg, Visipaque 320 mg, Bonorex 300 mg of iodine contrast medium. For image acquisition, planar imaging was consecutively filmed for 1, 2, 3, 4, 5 min, respectively, 30 min after administration of 99mTcO4. while 60 views were filmed per frame for 20 min at 55 min for the SPECT/CT imaging. In planar imaging, the gamma ray counting rates as a function of filming time were reduced showing a statistically significant difference when mixed according to the type of contrast medium density rather than when the radioactive isotope 99mTcO4 and the saline solution were mixed. In the tomography for mixing of the radioactive isotope 99mTcO4 and saline solution, the mean counting rate without correction by the CT absorption coefficient is 182±26 counts, while the counting rate with correction by the CT absorption coefficient is 531.3±34 counts. In the tomography for mixing of the radioactive isotope 99mTcO4 and the saline solution with the contrast medium, the mean values before attenuation correction by CT absorption coefficient were 166±29, 158.3±17, 154±36, and 150±33 counts depending on the densities of the contrast medium, while the mean values after attenuation correction were 515±03, 503±10, 496±31, and 488.7±33 counts, showing significant differences in both cases when comparatively evaluated with the imaging for no mixing of the contrast medium. Iodine contrast medium affects the rate of gamma ray. Therefore, You should always be preceded before another test on the day of diagnosis.

  12. Methodology for Gamma cameras calibration for I-131 uptake quantification in Hyperthyroidism diseases

    International Nuclear Information System (INIS)

    Lopez Diaz, A.; Palau San Pedro, A.; Martin Escuela, J. M.; Reynosa Montejo, R.; Castillo, J.; Torres Aroche, L.

    2015-01-01

    Optimization and verification of Patient-Specific Treatment Planning with unsealed I-131 sources is a desirable goal from medical and radiation protection point of view. To obtain a practical protocol to combine the estimation of the related parameters with patient's specific treatment dose in hyperthyroidism disease, 3 equipment were studied (Iodine Probe, a Philips Forte Camera with pin-hole collimators and a Mediso Nucline with HEGP for planar and SPECT techniques) and crossed calibrated. The linear behaviour on diagnostic and therapeutic activity range was verified, showing a linear correlation fitting factor R 2 > 0.99. The differences between thyroid uptake determinations in all equipment were less than 6% for therapeutic activities and less than 1.1% in the diagnostic range. The combined protocol to calculate, with only one administration of I 131 , all the necessary parameters to the treatment dose estimation in 2D or 3D, avoiding wasting time with gamma cameras, was established and verified. Following this protocol the difference between apparent and calculated activities were less than 3%. (Author)

  13. Cerebral emission computer tomography with a rotating gamma camera: clinic results with J-123 Isopropylamphetamin and J-123-Fenetyllin

    International Nuclear Information System (INIS)

    Biersack, H.J.; Hartmann, A.; Froescher, W.; Reske, S.-N.; Reichmann, K.; Knopp, R.; Winkler, C.

    1984-01-01

    Many amines can pass the blood brain barrier and accumulate in relatively large amounts in the brain tissue. For about 2 years 123-J amphetamines have, therefore, been used for brain imaging by several teams. Our experience sofar is based on 28 patients. Of these, 14 were epileptics, 10 had cerebrovascular diseases, 2 suffered from migraine and another 2 had brain tumors. In 3 patients with vascular lesions studies were repeated twice or three times. Amphetamine uptake in the brain was measured with a rotating gamma camera system (Gammatome T9000/CGR). At an examination time of 20 minutes 64 frames were acquired during one full rotation. The pulse rate was about 3000 second after injecting 6.5 mCi of 123-J amphetamine. Of the epileptics, 8 showed defects both on CT and SPECT, in 3 cases both studies were normal. While 1 patient with CT positivity had a normal SPECT, 2 cases were found to have lesions on SPECT inspite of a normal CT. The size of the lesion seen on amphetamine SPECT was lager than on CT in 3 of 9 patients. In the 10 patients with cerebrovascular lesions the 2 procedures showed concordant normal patterns in 1 and concordant abnormal patterns in 7 instances. 2 patients with normal CT were found to have a lesion on amphetamine scanning which corresponded to the neurologic findings. Regarding the size of the lesions, SPECT showed a more extensive involvement than CT in 2 cases. This again was in good agreement with the neurologic findings. Inspite of repeat studies cerebellar diaschisis was only seen in a single case with healed cerebral infarction and hemiplegia of some years' standing. Two patients suffered from migraine and compromised blood flow was identified as suggested by the neurologic findings inspite of a normal CT. (Author)

  14. The origins of SPECT and SPECT/CT

    Energy Technology Data Exchange (ETDEWEB)

    Hutton, Brian F. [University College London, Institute of Nuclear Medicine, London (United Kingdom); University of Wollongong, Centre for Medical Radiation Physics, Wollongong, NSW (Australia)

    2014-05-15

    Single photon emission computed tomography (SPECT) has a long history of development since its initial demonstration by Kuhl and Edwards in 1963. Although clinical utility has been dominated by the rotating gamma camera, there have been many technological innovations with the recent popularity of organ-specific dedicated SPECT systems. The combination of SPECT and CT evolved from early transmission techniques used for attenuation correction with the initial commercial systems predating the release of PET/CT. The development and acceptance of SPECT/CT has been relatively slow with continuing debate as to what cost/performance ratio is justified. Increasingly, fully diagnostic CT is combined with SPECT so as to facilitate optimal clinical utility. (orig.)

  15. Realization of a gamma emission tomography by a servo-controlled camera and bed

    International Nuclear Information System (INIS)

    Parmentier, M.; Gunzman, D.; Bidet, R.

    1979-01-01

    A gamma-camera and a whole-body bed were connected to a minicomputer which controlled automatically their movements. By combining horizontal displacement of the bed with vertical displacement and rotation of the camera we were able to obtain the equivalent of camera rotation around the bed. This method provides an inexpensive way of realizing gamma emission tomography [fr

  16. Upgrading of analogue gamma cameras with PC based computer system

    International Nuclear Information System (INIS)

    Fidler, V.; Prepadnik, M.

    2002-01-01

    Full text: Dedicated nuclear medicine computers for acquisition and processing of images from analogue gamma cameras in developing countries are in many cases faulty and technologically obsolete. The aim of the upgrading project of International Atomic Energy Agency (IAEA) was to support the development of the PC based computer system which would cost 5.000 $ in total. Several research institutions from different countries (China, Cuba, India and Slovenia) were financially supported in this development. The basic demands for the system were: one acquisition card an ISA bus, image resolution up to 256x256, SVGA graphics, low count loss at high count rates, standard acquisition and clinical protocols incorporated in PIP (Portable Image Processing), on-line energy and uniformity correction, graphic printing and networking. The most functionally stable acquisition system tested on several international workshops and university clinics was the Slovenian one with a complete set of acquisition and clinical protocols, transfer of scintigraphic data from acquisition card to PC through PORT, count loss less than 1 % at count rate of 120 kc/s, improvement of integral uniformity index by a factor of 3-5 times, reporting, networking and archiving solutions for simple MS network or server oriented network systems (NT server, etc). More than 300 gamma cameras in 52 countries were digitized and put in the routine work. The project of upgrading the analogue gamma cameras yielded a high promotion of nuclear medicine in the developing countries by replacing the old computer systems, improving the technological knowledge of end users on workshops and training courses and lowering the maintenance cost of the departments. (author)

  17. Clinical significance of gamma camera renography in chronic renal insufficiency

    International Nuclear Information System (INIS)

    Dudczak, R.; Frischauf, H.; Kletter, K.

    1980-01-01

    Gamma camera renography allows, together with renal imaging, an evaluation of individual renal function. For these examinations, I 123 orthoiodohippurate is preferred and most widely used. The results on patients with chronic renal insufficiency, including urologic and posttransplantation patients, are reported. Whereas the method is of clinical significance in evaluating posttransplantation complications and in assessing individual kidney function preoperatively in urology, as well as in monitoring therapeutic effects in the early period of renal disease, it is of limited diagnostic value in chronic renal insufficiency. In this latter regard, clinical and laboratory examinations are of primary importance. (author)

  18. A fast algorithm for computer aided collimation gamma camera (CACAO)

    Science.gov (United States)

    Jeanguillaume, C.; Begot, S.; Quartuccio, M.; Douiri, A.; Franck, D.; Pihet, P.; Ballongue, P.

    2000-08-01

    The computer aided collimation gamma camera is aimed at breaking down the resolution sensitivity trade-off of the conventional parallel hole collimator. It uses larger and longer holes, having an added linear movement at the acquisition sequence. A dedicated algorithm including shift and sum, deconvolution, parabolic filtering and rotation is described. Examples of reconstruction are given. This work shows that a simple and fast algorithm, based on a diagonal dominant approximation of the problem can be derived. Its gives a practical solution to the CACAO reconstruction problem.

  19. Energy independent uniformity improvement for gamma camera systems

    International Nuclear Information System (INIS)

    Lange, K.

    1979-01-01

    In a gamma camera system having an array of photomultiplier tubes for detecting scintillation events and preamplifiers connecting each tube to a weighting resistor matrix for determining the position coordinates of the events, means are provided for summing the signals from all photomultipliers to obtain the total energy of each event. In one embodiment, at least two different percentages of the summed voltage are developed and used to change the gain of the preamplifiers as a function of total energy when energies exceed specific levels to thereby obtain more accurate correspondence between the true coordinates of the event and its coordinates in a display

  20. Gamma camera system with composite solid state detector

    International Nuclear Information System (INIS)

    Gerber, M.S.; Miller, D.W.

    1977-01-01

    A composite solid-state detector is described for utilization within gamma cameras. The detector's formed of an array of detector crystals, the opposed surfaces of each of which are formed incorporating an impedance-derived configuration for determining one coordinate of the location of discrete impinging photons upon the detector. A combined read-out for all detectors within the composite array is achieved through a row and column interconnection of the impedance configurations. Utilizing the read-outs for respective sides of the discrete crystals, a resultant time-constant characteristic for the composite detector crystal array remains essentially that of individual crystal detectors

  1. Performance of cardiac cadmium-zinc-telluride gamma camera imaging in coronary artery disease: a review from the cardiovascular committee of the European Association of Nuclear Medicine (EANM)

    International Nuclear Information System (INIS)

    Agostini, Denis; Marie, Pierre-Yves; Ben-Haim, Simona; Rouzet, Francois; Songy, Bernard; Giordano, Alessandro; Gimelli, Alessia; Hyafil, Fabien; Sciagra, Roberto; Bucerius, Jan; Verberne, Hein J.; Slart, Riemer H.J.A.; Lindner, Oliver

    2016-01-01

    The trade-off between resolution and count sensitivity dominates the performance of standard gamma cameras and dictates the need for relatively high doses of radioactivity of the used radiopharmaceuticals in order to limit image acquisition duration. The introduction of cadmium-zinc-telluride (CZT)-based cameras may overcome some of the limitations against conventional gamma cameras. CZT cameras used for the evaluation of myocardial perfusion have been shown to have a higher count sensitivity compared to conventional single photon emission computed tomography (SPECT) techniques. CZT image quality is further improved by the development of a dedicated three-dimensional iterative reconstruction algorithm, based on maximum likelihood expectation maximization (MLEM), which corrects for the loss in spatial resolution due to line response function of the collimator. All these innovations significantly reduce imaging time and result in a lower patient's radiation exposure compared with standard SPECT. To guide current and possible future users of the CZT technique for myocardial perfusion imaging, the Cardiovascular Committee of the European Association of Nuclear Medicine, starting from the experience of its members, has decided to examine the current literature regarding procedures and clinical data on CZT cameras. The committee hereby aims (1) to identify the main acquisitions protocols; (2) to evaluate the diagnostic and prognostic value of CZT derived myocardial perfusion, and finally (3) to determine the impact of CZT on radiation exposure. (orig.)

  2. Performance of cardiac cadmium-zinc-telluride gamma camera imaging in coronary artery disease: a review from the cardiovascular committee of the European Association of Nuclear Medicine (EANM)

    Energy Technology Data Exchange (ETDEWEB)

    Agostini, Denis [CHU Caen and Normandy University, Department of Nuclear Medicine, Caen (France); Normandy University, Caen (France); Marie, Pierre-Yves [University of Lorraine, Faculty of Medicine, Nancyclotep Experimental Imaging Platform, Nancy (France); University of Lorraine, Faculty of Medicine, CHU Nancy, Department of Nuclear Medicine, Nancy (France); University of Lorraine, Faculty of Medicine, Nancy (France); Ben-Haim, Simona [University College London, University College Hospital, Institute of Nuclear Medicine, London (United Kingdom); Chaim Sheba Medical Center, Department of Nuclear Medicine, Ramat Gan (Israel); Rouzet, Francois [University Hospital of Paris-Bichat, UMR 1148, Inserm et Paris Diderot-Paris 7 University Paris, Department of Nuclear Medicine, Paris (France); UMR 1148, Inserm and Paris Diderot-Paris 7 University Paris, Paris (France); Songy, Bernard [Centre Cardiologique du Nord, Saint-Denis (France); Giordano, Alessandro [Institute of Nuclear Medicine, Catholic University of Sacred Heart, Largo A. Gemelli, Department of Bioimages and Radiological Sciences, Rome (Italy); Gimelli, Alessia [Fondazione Toscana Gabriele Monasterio, Pisa (Italy); Hyafil, Fabien [Bichat University Hospital, Assistance Publique - Hopitaux de Paris, UMR 1148, Inserm and Paris Diderot-Paris 7 University, Department of Nuclear Medicine, Paris (France); Sciagra, Roberto [University of Florence, Nuclear Medicine Unit, Department of Experimental and Clinical Biomedical Sciences, Florence (Italy); Bucerius, Jan [Maastricht University Medical Center, Maastricht University Medical Center, Department of Nuclear Medicine, Maastricht (Netherlands); Maastricht University Medical Center, Cardiovascular Research Institute Maastricht (CARIM), Maastricht (Netherlands); University Hospital RWTH Aachen, Department of Nuclear Medicine, Aachen (Germany); Verberne, Hein J. [Academic Medical Center, Department of Nuclear Medicine, Amsterdam (Netherlands); Slart, Riemer H.J.A. [University Medical Center Groningen, Department of Nuclear Medicine and Molecular Imaging, Groningen (Netherlands); University of Twente, Faculty of Science and Technology, Department of Biomedical Photonic Imaging, Enschede (Netherlands); Lindner, Oliver [Institute of Radiology, Nuclear Medicine and Molecular Imaging, Heart and Diabetes Center NRW, Bad Oeynhausen (Germany); Collaboration: Cardiovascular Committee of the European Association of Nuclear Medicine (EANM)

    2016-12-15

    The trade-off between resolution and count sensitivity dominates the performance of standard gamma cameras and dictates the need for relatively high doses of radioactivity of the used radiopharmaceuticals in order to limit image acquisition duration. The introduction of cadmium-zinc-telluride (CZT)-based cameras may overcome some of the limitations against conventional gamma cameras. CZT cameras used for the evaluation of myocardial perfusion have been shown to have a higher count sensitivity compared to conventional single photon emission computed tomography (SPECT) techniques. CZT image quality is further improved by the development of a dedicated three-dimensional iterative reconstruction algorithm, based on maximum likelihood expectation maximization (MLEM), which corrects for the loss in spatial resolution due to line response function of the collimator. All these innovations significantly reduce imaging time and result in a lower patient's radiation exposure compared with standard SPECT. To guide current and possible future users of the CZT technique for myocardial perfusion imaging, the Cardiovascular Committee of the European Association of Nuclear Medicine, starting from the experience of its members, has decided to examine the current literature regarding procedures and clinical data on CZT cameras. The committee hereby aims (1) to identify the main acquisitions protocols; (2) to evaluate the diagnostic and prognostic value of CZT derived myocardial perfusion, and finally (3) to determine the impact of CZT on radiation exposure. (orig.)

  3. Europe's space camera unmasks a cosmic gamma-ray machine

    Science.gov (United States)

    1996-11-01

    The new-found neutron star is the visible counterpart of a pulsating radio source, Pulsar 1055-52. It is a mere 20 kilometres wide. Although the neutron star is very hot, at about a million degrees C, very little of its radiant energy takes the form of visible light. It emits mainly gamma-rays, an extremely energetic form of radiation. By examining it at visible wavelengths, astronomers hope to figure out why Pulsar 1055-52 is the most efficient generator of gamma-rays known so far, anywhere the Universe. The Faint Object Camera found Pulsar 1055-52 in near ultraviolet light at 3400 angstroms, a little shorter in wavelength than the violet light at the extremity of the human visual range. Roberto Mignani, Patrizia Caraveo and Giovanni Bignami of the Istituto di Fisica Cosmica in Milan, Italy, report its optical identification in a forthcoming issue of Astrophysical Journal Letters (1 January 1997). The formal name of the object is PSR 1055-52. Evading the glare of an adjacent star The Italian team had tried since 1988 to spot Pulsar 1055-52 with two of the most powerful ground-based optical telescopes in the Southern Hemisphere. These were the 3.6-metre Telescope and the 3.5-metre New Technology Telescope of the European Southern Observatory at La Silla, Chile. Unfortunately an ordinary star 100,000 times brighter lay in almost the same direction in the sky, separated from the neutron star by only a thousandth of a degree. The Earth's atmosphere defocused the star's light sufficiently to mask the glimmer from Pulsar 1055-52. The astronomers therefore needed an instrument in space. The Faint Object Camera offered the best precision and sensitivity to continue the hunt. Devised by European astronomers to complement the American wide field camera in the Hubble Space Telescope, the Faint Object Camera has a relatively narrow field of view. It intensifies the image of a faint object by repeatedly accelerating electrons from photo-electric films, so as to produce

  4. A study of full width at half maximum (FWHM) according to the filter's cut off level in SPECT camera

    International Nuclear Information System (INIS)

    Park, Soung Ock; Kwon, Soo Il

    2003-01-01

    Filtering is necessary to reduce statistical noise and to increase image quality in SPECT images. Noises controlled by low-pass filter designed to suppress high spatial frequency in SPECT image. Most SPECT filter function control the degree of high frequency suppression by choosing a cut off frequency. The location of cut off frequency determines the affect image noise and spatial resolution. If select the low cut off frequency, its provide good noise suppression but insufficient image quantity and high cut off frequencies increase the image resolution but insufficient noise suppression. The purpose of this study was to determines the optimum cut off level with comparison of FWHM according to cut off level in each filters-Band-limited, Sheep-logan, Sheep-logan Hanning, Generalized Hamming, Low pass cosine, Parazen and Butterworth filter in SPECT camera. We recorded image along the X, Y, Z-axis with 99m TcO 4 point source and measured FWHM by use profile curve. We find averaged length is 9.16 mm ∼ 18.14 mm of FWHM in X, Y, and Z-axis, and Band-limited and Generalized Hamming filters measures 9.16 mm at 0.7 cycle/pixel cut off frequency

  5. Design of common software for quality control of SPECT

    International Nuclear Information System (INIS)

    Li Xiaohua; Gao Ruzhen; Chen Shengzu

    1993-01-01

    The goal of this study is to design a common testing system for SPECT quality control according to NEMA standard. Using the system, the performances of different types of SPECT can be tested, so that the acceptance testing, performance comparing and routine quality control for SPECT can be normalized. The system was based on IBM PC series of microcomputer. Testing data are acquired from various types of SPECT, then transferred into IBM PC through interface and tested with an unique testing program. Two parts were included: interface and SPECT testing program. It emphatically studied the managing program of RS232 interface, designing skills and the mathematic patterns of SPECT testing program. The system which was composed of 11 subroutines can be used to measure the performances for both gamma camera and SPECT. The system was tested on OMEGA 500/MCS 560 SPECT and the results showed that it is effective, accurate and easy to use

  6. PC based simulation of gamma camera for training of operating and maintenance staff

    International Nuclear Information System (INIS)

    Singh, B.; Kataria, S.K.; Samuel, A.M.

    2000-01-01

    Gamma camera- a sophisticated imaging system is used for functional assessment of biological subsystems/organs in nuclear medicine. The radioactive tracer attached to the native substance is injected into the patient. The distribution of radioactivity in the patient is imaged by the gamma camera. This report describes a PC based package for simulation of gamma cameras and effect of malfunctioning of its subsystems on images of different phantoms

  7. Depth-of-Interaction Compensation Using a Focused-Cut Scintillator for a Pinhole Gamma Camera

    Science.gov (United States)

    Alhassen, Fares; Kudrolli, Haris; Singh, Bipin; Kim, Sangtaek; Seo, Youngho; Gould, Robert G.; Nagarkar, Vivek V.

    2011-06-01

    Preclinical SPECT offers a powerful means to understand the molecular pathways of drug interactions in animal models by discovering and testing new pharmaceuticals and therapies for potential clinical applications. A combination of high spatial resolution and sensitivity are required in order to map radiotracer uptake within small animals. Pinhole collimators have been investigated, as they offer high resolution by means of image magnification. One of the limitations of pinhole geometries is that increased magnification causes some rays to travel through the detection scintillator at steep angles, introducing parallax errors due to variable depth-of-interaction in scintillator material, especially towards the edges of the detector field of view. These parallax errors ultimately limit the resolution of pinhole preclinical SPECT systems, especially for higher energy isotopes that can easily penetrate through millimeters of scintillator material. A pixellated, focused-cut (FC) scintillator, with its pixels laser-cut so that they are collinear with incoming rays, can potentially compensate for these parallax errors and thus improve the system resolution. We performed the first experimental evaluation of a newly developed focused-cut scintillator. We scanned a Tc-99 m source across the field of view of pinhole gamma camera with a continuous scintillator, a conventional “straight-cut” (SC) pixellated scintillator, and a focused-cut scintillator, each coupled to an electron-multiplying charge coupled device (EMCCD) detector by a fiber-optic taper, and compared the measured full-width half-maximum (FWHM) values. We show that the FWHMs of the focused-cut scintillator projections are comparable to the FWHMs of the thinner SC scintillator, indicating the effectiveness of the focused-cut scintillator in compensating parallax errors.

  8. Depth-of-Interaction Compensation Using a Focused-Cut Scintillator for a Pinhole Gamma Camera.

    Science.gov (United States)

    Alhassen, Fares; Kudrolli, Haris; Singh, Bipin; Kim, Sangtaek; Seo, Youngho; Gould, Robert G; Nagarkar, Vivek V

    2011-06-01

    Preclinical SPECT offers a powerful means to understand the molecular pathways of drug interactions in animal models by discovering and testing new pharmaceuticals and therapies for potential clinical applications. A combination of high spatial resolution and sensitivity are required in order to map radiotracer uptake within small animals. Pinhole collimators have been investigated, as they offer high resolution by means of image magnification. One of the limitations of pinhole geometries is that increased magnification causes some rays to travel through the detection scintillator at steep angles, introducing parallax errors due to variable depth-of-interaction in scintillator material, especially towards the edges of the detector field of view. These parallax errors ultimately limit the resolution of pinhole preclinical SPECT systems, especially for higher energy isotopes that can easily penetrate through millimeters of scintillator material. A pixellated, focused-cut (FC) scintillator, with its pixels laser-cut so that they are collinear with incoming rays, can potentially compensate for these parallax errors and thus improve the system resolution. We performed the first experimental evaluation of a newly developed focused-cut scintillator. We scanned a Tc-99m source across the field of view of pinhole gamma camera with a continuous scintillator, a conventional "straight-cut" (SC) pixellated scintillator, and a focused-cut scintillator, each coupled to an electron-multiplying charge coupled device (EMCCD) detector by a fiber-optic taper, and compared the measured full-width half-maximum (FWHM) values. We show that the FWHMs of the focused-cut scintillator projections are comparable to the FWHMs of the thinner SC scintillator, indicating the effectiveness of the focused-cut scintillator in compensating parallax errors.

  9. The effect of truncation on very small cardiac SPECT camera systems

    International Nuclear Information System (INIS)

    Rohmer, Damien; Eisner, Robert L.; Gullberg, Grant T.

    2006-01-01

    Background: The limited transaxial field-of-view (FOV) of a very small cardiac SPECT camera system causes view-dependent truncation of the projection of structures exterior to, but near the heart. Basic tomographic principles suggest that the reconstruction of non-attenuated truncated data gives a distortion-free image in the interior of the truncated region, but the DC term of the Fourier spectrum of the reconstructed image is incorrect, meaning that the intensity scale of the reconstruction is inaccurate. The purpose of this study was to characterize the reconstructed image artifacts from truncated data, and to quantify their effects on the measurement of tracer uptake in the myocardial. Particular attention was given to instances where the heart wall is close to hot structures (structures of high activity uptake).Methods: The MCAT phantom was used to simulate a 2D slice of the heart region. Truncated and non-truncated projections were formed both with and without attenuation. The reconstructions were analyzed for artifacts in the myocardium caused by truncation, and for the effect that attenuation has relative to increasing those artifacts. Results: The inaccuracy due to truncation is primarily caused by an incorrect DC component. For visualizing the left ventricular wall, this error is not worse than the effect of attenuation. The addition of a small hot bowel-like structure near the left ventricle causes few changes in counts on the wall. Larger artifacts due to the truncation are located at the boundary of the truncation and can be eliminated by sinogram interpolation. Finally,algebraic reconstruction methods are shown to give better reconstruction results than an analytical filtered back-projection reconstruction algorithm. Conclusion: Small inaccuracies in reconstructed images from small FOV camera systems should have little effect on clinical interpretation. However, changes in the degree of inaccuracy in counts from slice to slice are due to changes in

  10. 3D tomographic imaging with the γ-eye planar scintigraphic gamma camera

    Science.gov (United States)

    Tunnicliffe, H.; Georgiou, M.; Loudos, G. K.; Simcox, A.; Tsoumpas, C.

    2017-11-01

    γ-eye is a desktop planar scintigraphic gamma camera (100 mm × 50 mm field of view) designed by BET Solutions as an affordable tool for dynamic, whole body, small-animal imaging. This investigation tests the viability of using γ-eye for the collection of tomographic data for 3D SPECT reconstruction. Two software packages, QSPECT and STIR (software for tomographic image reconstruction), have been compared. Reconstructions have been performed using QSPECT’s implementation of the OSEM algorithm and STIR’s OSMAPOSL (Ordered Subset Maximum A Posteriori One Step Late) and OSSPS (Ordered Subsets Separable Paraboloidal Surrogate) algorithms. Reconstructed images of phantom and mouse data have been assessed in terms of spatial resolution, sensitivity to varying activity levels and uniformity. The effect of varying the number of iterations, the voxel size (1.25 mm default voxel size reduced to 0.625 mm and 0.3125 mm), the point spread function correction and the weight of prior terms were explored. While QSPECT demonstrated faster reconstructions, STIR outperformed it in terms of resolution (as low as 1 mm versus 3 mm), particularly when smaller voxel sizes were used, and in terms of uniformity, particularly when prior terms were used. Little difference in terms of sensitivity was seen throughout.

  11. Gamma camera system with improved means for correcting nonuniformity

    International Nuclear Information System (INIS)

    Lange, K.; Jeppesen, J.

    1979-01-01

    In a gamma camera system, means are provided for correcting nonuniformity or lack of correspondence between the positions of scintillations and their calculated and displayed by x-y coordinates. In an accumulation mode, pulse counts corresponding with scintillations in various areas of the radiation field are stored in memory locations corresponding with their locations in the radiation field. A uniform radiation source is presented to the detectors during the accumulation is interrupted at which time other locations have fewer counts in them. In the run mode, counts are stored in corresponding locations of a memory and these counts are compared continuously with those stored in the accumulation mode. Means are provided for injecting a number of counts during the run mode proportional to the difference between the counts accumulated during the accumulation mode in a given area increment and the counts that should have been obtained from a uniform source

  12. A new gamma camera for positron emission tomography

    International Nuclear Information System (INIS)

    Schotanus, P.

    1988-01-01

    This thesis describes the detection of annihiliation radiation employing a new principle: radiation is absorbed in a barium fluoride (BaF 2) crystal and the resulting scintillation light is detected in a multiwire proportional chamber filled with a photsensitive vapour. The application of such a detector for PET is new; the use of a high density fast scintillator in combination with a low pressure wire chamber offers a good detection efficiency and permits high count rates because of the small dead time. In this work, the physical background of the above detection mechanism is explored and the performance parameters of a gamma camera using this new principle, are determined. Furthermore, a comprehensive research on the scintillation mechanism and physical characteristics of the increasingly popular BaF 2 scintillator is presented. Also, a new class of ultraviolet (UV) scintillation materials, consisting of rare earth doped fluorides, is introduced. (author). 211 refs.; 30 figs.; 17 tabs

  13. Quality control of the gamma camera/computer interface

    International Nuclear Information System (INIS)

    Busemann-Sokole, E.

    1983-01-01

    Reporting on the conference mentioned, the author indicates that technical inspection of the gamma camera and the attached computer each by themselves is not sufficient. The parts of the interface and the hardware or software can contain sources of error. In order to obtain the best diagnostic image a number of control measurements are recommended dealing with image intensifying, intensifier offset, linearity of transformation, exclusion of 'data drop' or 'bit drop', 2-pulse timing, correct response with different counting rates, and response to triggers (electrocardiogram). The last and most important recommendation is to record in writing particulars of each inspection and control measurement, particulars and solutions of problems and modifications in hardware and software. (Auth.)

  14. Inter-laboratory comparison study of gamma cameras in Pakistan

    International Nuclear Information System (INIS)

    Shahid, M.A.; Mumtaz-ul-Haq

    1988-01-01

    The evaluation of the performance of both instrument and the physician are important in any quality assurance programme in nuclear medicine imaging. The IAEA launched a similar program in 1984 under its Regional Cooperation Agreement program in South Asian Countries. The first part of the study consisted of the evaluation of imaging equipment by imaging IAEA-WHO Simulated Anatomic Liver Phantom (SALP) and its interpretation by the physician. From Pakistan, 8 gamma cameras from 7 laboratories were used for the study and 16 physician interpreted in the SALP images. This paper reports the results of SALP images from Pakistan and shows the efficacy of 80 to 100% as regards the quality of image obtained and the interpretation done by the physicians. (author)

  15. Applications of cerebral SPECT

    Energy Technology Data Exchange (ETDEWEB)

    McArthur, C., E-mail: claire.mcarthur@nhs.net [Department of Neuroradiology, Institute of Neurological Sciences, Glasgow (United Kingdom); Jampana, R.; Patterson, J.; Hadley, D. [Department of Neuroradiology, Institute of Neurological Sciences, Glasgow (United Kingdom)

    2011-07-15

    Single-photon emission computed tomography (SPECT) can provide three-dimensional functional images of the brain following the injection of one of a series of radiopharmaceuticals that crosses the blood-brain barrier and distributes according to cerebral perfusion, neurotransmitter, or cell density. Applications include differentiating between the dementias, evaluating cerebrovascular disease, preoperative localization of epileptogenic foci, diagnosing movement disorders, and evaluation of intracerebral tumours, while also proving a useful research tool. Unlike positronemission tomography (PET), SPECT imaging is widely available and can be performed in any department that has access to a rotating gamma camera. The purpose of this review is to demonstrate the utility of cerebral SPECT and increase awareness of its role in the investigation of neurological and psychiatric disorders.

  16. A panoramic coded aperture gamma camera for radioactive hotspots localization

    Science.gov (United States)

    Paradiso, V.; Amgarou, K.; Blanc De Lanaute, N.; Schoepff, V.; Amoyal, G.; Mahe, C.; Beltramello, O.; Liénard, E.

    2017-11-01

    A known disadvantage of the coded aperture imaging approach is its limited field-of-view (FOV), which often results insufficient when analysing complex dismantling scenes such as post-accidental scenarios, where multiple measurements are needed to fully characterize the scene. In order to overcome this limitation, a panoramic coded aperture γ-camera prototype has been developed. The system is based on a 1 mm thick CdTe detector directly bump-bonded to a Timepix readout chip, developed by the Medipix2 collaboration (256 × 256 pixels, 55 μm pitch, 14.08 × 14.08 mm2 sensitive area). A MURA pattern coded aperture is used, allowing for background subtraction without the use of heavy shielding. Such system is then combined with a USB color camera. The output of each measurement is a semi-spherical image covering a FOV of 360 degrees horizontally and 80 degrees vertically, rendered in spherical coordinates (θ,phi). The geometrical shapes of the radiation-emitting objects are preserved by first registering and stitching the optical images captured by the prototype, and applying, subsequently, the same transformations to their corresponding radiation images. Panoramic gamma images generated by using the technique proposed in this paper are described and discussed, along with the main experimental results obtained in laboratories campaigns.

  17. Two dimensional spatial distortion correction algorithm for scintillation GAMMA cameras

    International Nuclear Information System (INIS)

    Chaney, R.; Gray, E.; Jih, F.; King, S.E.; Lim, C.B.

    1985-01-01

    Spatial distortion in an Anger gamma camera originates fundamentally from the discrete nature of scintillation light sampling with an array of PMT's. Historically digital distortion correction started with the method based on the distortion measurement by using 1-D slit pattern and the subsequent on-line bi-linear approximation with 64 x 64 look-up tables for X and Y. However, the X, Y distortions are inherently two-dimensional in nature, and thus the validity of this 1-D calibration method becomes questionable with the increasing distortion amplitude in association with the effort to get better spatial and energy resolutions. The authors have developed a new accurate 2-D correction algorithm. This method involves the steps of; data collection from 2-D orthogonal hole pattern, 2-D distortion vector measurement, 2-D Lagrangian polynomial interpolation, and transformation to X, Y ADC frame. The impact of numerical precision used in correction and the accuracy of bilinear approximation with varying look-up table size have been carefully examined through computer simulation by using measured single PMT light response function together with Anger positioning logic. Also the accuracy level of different order Lagrangian polynomial interpolations for correction table expansion from hole centroids were investigated. Detailed algorithm and computer simulation are presented along with camera test results

  18. Comparison of myocardial perfusion imaging between the new high-speed gamma camera and the standard anger camera

    International Nuclear Information System (INIS)

    Tanaka, Hirokazu; Chikamori, Taishiro; Hida, Satoshi

    2013-01-01

    Cadmium-zinc-telluride (CZT) solid-state detectors have been recently introduced into the field of myocardial perfusion imaging. The aim of this study was to prospectively compare the diagnostic performance of the CZT high-speed gamma camera (Discovery NM 530c) with that of the standard 3-head gamma camera in the same group of patients. The study group consisted of 150 consecutive patients who underwent a 1-day stress-rest 99m Tc-sestamibi or tetrofosmin imaging protocol. Image acquisition was performed first on a standard gamma camera with a 15-min scan time each for stress and for rest. All scans were immediately repeated on a CZT camera with a 5-min scan time for stress and a 3-min scan time for rest, using list mode. The correlations between the CZT camera and the standard camera for perfusion and function analyses were strong within narrow Bland-Altman limits of agreement. Using list mode analysis, image quality for stress was rated as good or excellent in 97% of the 3-min scans, and in 100% of the ≥4-min scans. For CZT scans at rest, similarly, image quality was rated as good or excellent in 94% of the 1-min scans, and in 100% of the ≥2-min scans. The novel CZT camera provides excellent image quality, which is equivalent to standard myocardial single-photon emission computed tomography, despite a short scan time of less than half of the standard time. (author)

  19. Myocardial perfusion imaging with a cadmium zinc telluride-based gamma camera versus invasive fractional flow reserve

    Energy Technology Data Exchange (ETDEWEB)

    Mouden, Mohamed [Isala klinieken, Department of Cardiology, Zwolle (Netherlands); Isala klinieken, Department of Nuclear Medicine, Zwolle (Netherlands); Ottervanger, Jan Paul; Timmer, Jorik R. [Isala klinieken, Department of Cardiology, Zwolle (Netherlands); Knollema, Siert; Reiffers, Stoffer; Oostdijk, Ad H.J.; Jager, Pieter L. [Isala klinieken, Department of Nuclear Medicine, Zwolle (Netherlands); Boer, Menko-Jan de [University Medical Centre Nijmegen, Department of Cardiology, Nijmegen (Netherlands)

    2014-05-15

    Recently introduced ultrafast cardiac SPECT cameras with cadmium zinc telluride-based (CZT) detectors may provide superior image quality allowing faster acquisition with reduced radiation doses. Although the level of concordance between conventional SPECT and invasive fractional flow reserve (FFR) measurement has been studied, that between FFR and CZT-based SPECT is not yet known. Therefore, we aimed to assess the level of concordance between CZT SPECT and FFR in a large patient group with stable coronary artery disease. Both invasive FFR and myocardial perfusion imaging with a CZT-based SPECT camera, using Tc-tetrofosmin as tracer, were performed in 100 patients with stable angina and intermediate grade stenosis on invasive coronary angiography. A cut-off value of <0.75 was used to define abnormal FFR. The mean age of the patients was 64 ± 11 years, and 64 % were men. SPECT demonstrated ischaemia in 31 % of the patients, and 20 % had FFR <0.75. The concordance between CZT SPECT and FFR was 73 % on a per-patient basis and 79 % on a per-vessel basis. Discordant findings were more often seen in older patients and were mainly (19 %) the result of ischaemic SPECT findings in patients with FFR ≥0.75, whereas only 8 % had an abnormal FFR without ischaemia as demonstrated by CZT SPECT. Only 20 - 30 % of patients with intermediate coronary stenoses had significant ischaemia as assessed by CZT SPECT or invasive FFR. CZT SPECT showed a modest degree of concordance with FFR, which is comparable with previous results with conventional SPECT. Further investigations are particularly necessary in patients with normal SPECT and abnormal FFR, especially to determine whether these patients should undergo revascularization. (orig.)

  20. Advances in SPECT Instrumentation (Including Small Animal Scanners). Chapter 4

    International Nuclear Information System (INIS)

    Di Domenico, G.; Zavattini, G.

    2009-01-01

    Fundamental major efforts have been devoted to the development of positron emission tomography (PET) imaging modality over the last few decades. Recently, a novel surge of interest in single photon emission computed tomography (SPECT) technology has occurred, particularly after the introduction of the hybrid SPECT-CT imaging system. This has led to a flourishing of investigations in new types of detectors and collimators, and to more accurate refinement of reconstruction algorithms. Along with SPECT-CT, new, fast gamma cameras have been developed for dedicated cardiac imaging. The existing gap between PET and SPECT in sensitivity and spatial resolution is progressively decreasing, and this trend is particularly apparent in the field of small animal imaging where the most important advances have been reported in SPECT tomographs. An outline of the basic features of SPECT technology, and of recent developments in SPECT instrumentation for both clinical applications and basic biological research on animal models is described. (author)

  1. Investigation of high resolution compact gamma camera module based on a continuous scintillation crystal using a novel charge division readout method

    International Nuclear Information System (INIS)

    Dai Qiusheng; Zhao Cuilan; Qi Yujin; Zhang Hualin

    2010-01-01

    The objective of this study is to investigate a high performance and lower cost compact gamma camera module for a multi-head small animal SPECT system. A compact camera module was developed using a thin Lutetium Oxyorthosilicate (LSO) scintillation crystal slice coupled to a Hamamatsu H8500 position sensitive photomultiplier tube (PSPMT). A two-stage charge division readout board based on a novel subtractive resistive readout with a truncated center-of-gravity (TCOG) positioning method was developed for the camera. The performance of the camera was evaluated using a flood 99m Tc source with a four-quadrant bar-mask phantom. The preliminary experimental results show that the image shrinkage problem associated with the conventional resistive readout can be effectively overcome by the novel subtractive resistive readout with an appropriate fraction subtraction factor. The response output area (ROA) of the camera shown in the flood image was improved up to 34%, and an intrinsic spatial resolution better than 2 mm of detector was achieved. In conclusion, the utilization of a continuous scintillation crystal and a flat-panel PSPMT equipped with a novel subtractive resistive readout is a feasible approach for developing a high performance and lower cost compact gamma camera. (authors)

  2. Development Of Software For Automation And Data Acquisition System For Gamma Spider And SPECT

    International Nuclear Information System (INIS)

    Maslina Mohd Ibrahim; Jaafar Abdullah; Nolida Yussup; Nur Aira Abd Rahman; Mukhlis Mokhtar; Hanafi Ithnin; Hearie Hassan

    2014-01-01

    The portable system of gamma-ray computed tomography known as Gamma Spider and Single-Photon Emission Computed Tomography (SPECT) are designed for the detection and measurement of the physical condition of small object that can fit within the diameter of 50 cm. The project consists of two major components; the scanner hardware and the system software. This paper describes the system software components which are linear and rotate motor control, data acquisition for rate meter and data recording. The scanning resolution for linear movement can be set to 0.25 cm, 0.5 cm or 1.0 cm whereas the rotation movement can be set to 5 or 10 degree depending on user requirement. The selections for scanning offset are set to three diameters which are 30 cm, 40 cm and 50 cm. The algorithm for this automation system and issues on development are also discussed in this paper. (author)

  3. Gamma camera correction system and method for using the same

    International Nuclear Information System (INIS)

    Inbar, D.; Gafni, G.; Grimberg, E.; Bialick, K.; Koren, J.

    1986-01-01

    A gamma camera is described which consists of: (a) a detector head that includes photodetectors for producing output signals in response to radiation stimuli which are emitted by a radiation field and which interact with the detector head and produce an event; (b) signal processing circuitry responsive to the output signals of the photodetectors for producing a sum signal that is a measure of the total energy of the event; (c) an energy discriminator having a relatively wide window for comparison with the sum signal; (d) the signal processing circuitry including coordinate computation circuitry for operating on the output signals, and calculating an X,Y coordinate of an event when the sum signal lies within the window of the energy discriminator; (e) an energy correction table containing spatially dependent energy windows for producing a validation signal if the total energy of an event lies within the window associated with the X,Y coordinates of the event; (f) the signal processing circuitry including a dislocation correction table containing spatially dependent correction factors for converting the X,Y coordinates of an event to relocated coordinates in accordance with correction factors determined by the X,Y coordinates; (g) a digital memory for storing a map of the radiation field; and (h) means for recording an event at its relocated coordinates in the memory if the energy correction table produces a validation signal

  4. Standardization of the intrinsic uniformity control of the gamma cameras

    International Nuclear Information System (INIS)

    Solsona Harster, Lluis; Llopis Gonzalez, David; Pavia Segura, Javier

    2001-01-01

    Objective: To verify the Intrinsic Uniformity (Iu) results using different acquisition parameters in the weekly gamma camera Quality Control (Qc). Material And Methods: We made 4 experiments using Tc99 sources and modifying the orientation, distance, activity an volume parameters of a source in ten detectors with I Na photomultipliers applying the following acquisition conditions: 4000 Kc, the source 2 m far from the geometrical centre of the detectors, 0.1 ml into 1 ml syringe, and 150 Tc99m ?Ci. Results: We found better results when the distance between detector/source is getting longer, but the better point we found between 1,5 and 2 m. We also found necessary the collimator position was parallel respect to the geometrical centre field of view, because a little deviation of only two degrees can offer a bad result between +0.5%. We study the dose that we should use, and the results show us that better results are not in the highest or smallest values of activity into the source. In volume parameters, we can see that if we use a source highest than 1 ml we obtained better results. Conclusion: Following our results in the variation of IU values as for as the distance, rotation detector/source, dose and source activity, we recommend to perform this QC applying NEMA rules in same conditions every week and using the different parameters of our study to obtain better IU (Au)

  5. Preliminary study for pixel identification on a modular gamma camera

    Energy Technology Data Exchange (ETDEWEB)

    Soluri, A., E-mail: soluri@isib.cnr.it; Atzeni, G.; Ucci, A.; Cusanno, F.; Massari, R.

    2014-02-01

    Our group has recently investigated and produced new scintigraphic prototypes based on advanced scintillation structure. The aim of this study is to demonstrate the use of scintillation matrices with size equal to the overall area of the Position Sensitive Photomultiplier Tube (PSPMT), to design a modular gamma camera and study the solution of the dead area problems optimizing the overall pixel identification. In this paper we investigate the response of different combinations with crystals integrated within tungsten structure, coupled with H8500, R8900-C12 and R11265-M64 Hamamatsu PSPMTs. Several scintillation matrices, whose dimensions match to the physical area of the PSPMT, have been analysed so that we have also studied limits of detection for the elements of the matrix in the critical zones of the PSPMT, i.e. corners and borders. In order to enhance the detectability of scintillation elements we improved the light collection by depositing metallic layers or treating the tungsten structure with different coating materials, and shaping the external elements of the scintillation matrices. The results have shown good energy resolution and the proposed method can be applied in medical imaging for obtaining high efficiency scintillation devices.

  6. Assessment of gamma camera performance at some Sudanese hospitals

    International Nuclear Information System (INIS)

    Ibrahim, Nour El huda Ibrahim Ali

    2016-05-01

    The study aims to investigate the performance quality of the gamma cameras used in three public hospitals in Sudan. It is widely recognized that the attainment of high standards of efficiency and reliability in the practice of nuclear medicine, as in other specialties based on advanced technology, requires an appropriate quality assurance program. In this study we have focused on four of the main tests in order to assess the performance of the three units in question, such as uniformity, resolution/ linearity, center of rotation, photopeak. The values were within the acceptable range (according to the adopted protocols). Overall performance of the units was acceptable. Although all the results were within the acceptable range, some of them were at border, thus an action of preventive maintenance should be considered. It is noticed that a minor to negligible co-operation exists between the centers experts and /or equipment. The establishment of an external and internal auditing program is recommended. More co-operation between the centers should be considered.(Author)

  7. SU-C-201-07: Validation of a GATE Gamma Camera Model for the Siemens Symbia

    International Nuclear Information System (INIS)

    Mikell, J; Siman, W; Kappadath, S; Mourtada, F

    2015-01-01

    Purpose: To develop a simulation model of a clinical gamma camera/SPECT system and to validate the model using experimental and published measurements from the clinical system. Methods: Geant4 Application for Tomographic Emission (GATE) was used to create a model of the Siemens Symbia gamma camera. A modular model was implemented that allows specifying combinations of crystal thickness (3/8”, 5/8”) and collimator (LEHR, MELP, HE). Shielding, energy resolution, intrinsic resolution, crystal thickness, and collimator properties were set based on manufacturer specifications. Validation of the model was performed by simulating NEMA 2007 gamma camera tests including spatial resolution and sensitivity for Tc99; these were compared with experimental and published data for the scanner. The simulated energy spectra of a Tc99 line source in acrylic blocks was visually compared with the corresponding experimental acquisition. For a 4 cm diameter sphere filled with Tc99, the attenuation maps were generated from simulation data, and the photopeak and scatter window were extracted from GATE output using ROOT to create DICOM files to use in the clinical reconstruction. Results: Simulated spatial resolutions for LEHR 3/8” crystal at 0, 10 cm, 10 cm (with scatter), and 30 cm were 4, 6.7, 7.9, and 14.5 mm FWHM; these were 9% less than published data. For 5/8” crystal the spatial resolutions were 4.5, 7.0, 8.5, and 14.7 mm FWHM; these were 4% to 10% less than published data. Simulated sensitivity was within 3.5% of published data for both LEHR 3/8” and 5/8”. The simulated energy spectra matched the photopeak and scatter window well, but did overestimate the counts below 90 keV. The simulated attenuation map and projection data were successfully reconstructed with the clinical software, and the passed visual inspection. Conclusions: Validation of a specific clinical scanner allows future studies of quantification accuracy for both planar and SPECT imaging. Research

  8. SU-C-201-07: Validation of a GATE Gamma Camera Model for the Siemens Symbia

    Energy Technology Data Exchange (ETDEWEB)

    Mikell, J; Siman, W; Kappadath, S [Department of Imaging Physics, University of Texas MD Anderson Cancer Center, Houston, TX (United States); University of Texas Graduate School of Biomedical Sciences at Houston, Houston, TX (United States); Mourtada, F [Christiana Care Hospital, Newark, DE (United States); Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston TX (United States); Department of Radiation Oncology, Thomas Jefferson University, Philadelphia, PA (United States)

    2015-06-15

    Purpose: To develop a simulation model of a clinical gamma camera/SPECT system and to validate the model using experimental and published measurements from the clinical system. Methods: Geant4 Application for Tomographic Emission (GATE) was used to create a model of the Siemens Symbia gamma camera. A modular model was implemented that allows specifying combinations of crystal thickness (3/8”, 5/8”) and collimator (LEHR, MELP, HE). Shielding, energy resolution, intrinsic resolution, crystal thickness, and collimator properties were set based on manufacturer specifications. Validation of the model was performed by simulating NEMA 2007 gamma camera tests including spatial resolution and sensitivity for Tc99; these were compared with experimental and published data for the scanner. The simulated energy spectra of a Tc99 line source in acrylic blocks was visually compared with the corresponding experimental acquisition. For a 4 cm diameter sphere filled with Tc99, the attenuation maps were generated from simulation data, and the photopeak and scatter window were extracted from GATE output using ROOT to create DICOM files to use in the clinical reconstruction. Results: Simulated spatial resolutions for LEHR 3/8” crystal at 0, 10 cm, 10 cm (with scatter), and 30 cm were 4, 6.7, 7.9, and 14.5 mm FWHM; these were 9% less than published data. For 5/8” crystal the spatial resolutions were 4.5, 7.0, 8.5, and 14.7 mm FWHM; these were 4% to 10% less than published data. Simulated sensitivity was within 3.5% of published data for both LEHR 3/8” and 5/8”. The simulated energy spectra matched the photopeak and scatter window well, but did overestimate the counts below 90 keV. The simulated attenuation map and projection data were successfully reconstructed with the clinical software, and the passed visual inspection. Conclusions: Validation of a specific clinical scanner allows future studies of quantification accuracy for both planar and SPECT imaging. Research

  9. Evaluation of tomographic ISOCAM Park II gamma camera parameters using Monte Carlo method

    International Nuclear Information System (INIS)

    Oramas Polo, Ivón

    2015-01-01

    In this paper the evaluation of tomographic ISOCAM Park II gamma camera parameters was performed using the Monte Carlo code SIMIND. The parameters uniformity, resolution and contrast were evaluated by Jaszczak phantom simulation. In addition the qualitative assessment of the center of rotation was performed. The results of the simulation are compared and evaluated against the specifications of the manufacturer of the gamma camera and taking into account the National Protocol for Quality Control of Nuclear Medicine Instruments of the Cuban Medical Equipment Control Center. A computational Jaszczak phantom model with three different distributions of activity was obtained. They can be used to perform studies with gamma cameras. (author)

  10. Principle of some gamma cameras (efficiencies, limitations, development)

    International Nuclear Information System (INIS)

    Allemand, R.; Bourdel, J.; Gariod, R.; Laval, M.; Levy, G.; Thomas, G.

    1975-01-01

    The quality of scintigraphic images is shown to depend on the efficiency of both the input collimator and the detector. Methods are described by which the quality of these images may be improved by adaptations to either the collimator (Fresnel zone camera, Compton effect camera) or the detector (Anger camera, image amplification camera). The Anger camera and image amplification camera are at present the two main instruments whereby acceptable space and energy resolutions may be obtained. A theoretical comparative study of their efficiencies is carried out, independently of their technological differences, after which the instruments designed or under study at the LETI are presented: these include the image amplification camera, the electron amplifier tube camera using a semi-conductor target CdTe and HgI 2 detector [fr

  11. Evaluation of performance quality of SPECT camera in Sharyati Hospital of Tehran University of Medical Sciences

    International Nuclear Information System (INIS)

    Takavar, A.

    2001-01-01

    In nuclear medicine, there are two methods of imaging, planar and tomography. Single photon emission computerized tomography (SPECT) shows better image details and therefore is influenced more by image parameters such as resolution, uniformity, sensitivity, etc. Manufacturers provide customers with data which are obtained by complicated and sometimes secret methods. Marketing companies test and verify these data and buyers perform acceptance testing on installation of system. Since acceptance testing is not usually done in our country, follow up of system performance and therefore setting up of a comprehensive quality control program faces difficulty. In this research which was done sometimes after installation, evaluation of SPECT system was carried out and data obtained were compared with those of manufacturer catalogue. It was found that in most cases our figures do not correspond to those of manufacturer catalogue, therefore acceptance testing using standard and precision devices being carried out by trained personnel is strongly recommended

  12. A low-cost phantom for simple routine testing of single photon emission computed tomography (SPECT) cameras

    International Nuclear Information System (INIS)

    Ng, A.H.; Ng, K.H.; Dharmendra, H.; Perkins, A.C.

    2009-01-01

    A simple sphere test phantom has been developed for routine performance testing of SPECT systems in situations where expensive commercial phantoms may not be available. The phantom was based on a design with six universal syringe hubs set in the frame to support a circular array of six glass blown spheres of different sizes. The frame was then placed into a water-filled CT abdomen phantom and scanned with a triple head camera system (Philips IRIX TM , USA). Comparison was made with a commercially available phantom (Deluxe Jaszczak phantom). Whereas the commercial phantom demonstrates cold spot resolution, an important advantage of the sphere test phantom was that hot spot resolution could be easily measured using almost half (370 MBq) of the activity recommended for use in the commercial phantom. Results showed that the contrast increased non-linearly with sphere volume and radionuclide concentration. The phantom was found to be suitable as an inexpensive option for daily performance tests.

  13. Design of gamma camera data acquisition system based on PCI9810

    International Nuclear Information System (INIS)

    Zhao Yuanyuan; Zhao Shujun; Liu Yang

    2004-01-01

    This paper describe the design of gamma camera's data acquisition system, which is based on PCI9810 data acquisition card of ADLink Technology Inc. The main function of PCI9810 and the program of data acquisition system are described. (authors)

  14. Improving the spatial resolution of the multiple multiwire proportional chamber gamma camera

    International Nuclear Information System (INIS)

    Bateman, J.E.; Connolly, J.F.

    1978-03-01

    Results are presented showing how the spatial resolution of the multiple multiwire proportional chamber (MMPC) gamma camera may be improved. Under the best conditions 1.6 mm bars can be resolved. (author)

  15. Planar gamma camera imaging and quantitation of Yttrium-90 bremsstrahlung

    International Nuclear Information System (INIS)

    Shen, S.; DeNardo, G.L.; Yuan, A.

    1994-01-01

    Yttrium-90 is a promising radionuclide for radioimmunotherapy of cancer because of its energetic beta emissions. Therapeutic management requires quantitative imaging to assess the pharmacokinetics and radiation dosimetry of the 90 Y-labeled antibody. Conventional gamma photon imaging methods cannot be easily applied to imaging of 90 Y-bremsstrahlung because of its continuous energy spectrum. The sensitivity, resolution and source-to-background signal ratio (S/B) of the detector system for 90 Y-bremsstrahlung were investigated for various collimators and energy windows in order to determine optimum conditions for quantitative imaging. After these conditions were determined, the accuracy of quantitation of 90 Y activity in an Alderson abdominal phantom was examined. When the energy-window width was increased, the benefit of increased sensitivity outweighed degradation in resolution and S/B ratio until the manufacturer's energy specifications for the collimator were exceeded. Using the same energy window, the authors improved resolution and S/B for the medium-energy (ME) collimator when compared to the low-energy, all-purpose (LEAP) collimator, and there was little additional improvement using the high-energy (HE) collimator. Camera sensitivity under tissue equivalent conditions was 4.2 times greater for the LEAP and 1.7 times greater for the ME collimators when compared to the HE collimator. Thus, the best, most practical selections were found to be the ME collimator and an energy window of 55-285 keV. When they used these optimal conditions for image acquisition, the estimation of 90 Y activity in organs and tumors was within 15% of the true activities. The results for this study suggest that reasonable accuracy can be achieved in clinical radioimmunotherapy using 90 Y-bremsstrahlung quantitation. 28 refs., 5 figs., 7 tabs

  16. A study on the performance evaluation of small gamma camera collimators using detective quantun efficiency

    International Nuclear Information System (INIS)

    Jeon, Ho Sang

    2008-02-01

    The anger-type gamma camera and novel marker compound using Tc-99m were firstly introduced in 1963. The gamma camera systems have being improved and applied to various fields, for example, medical, industrial, and environmental fields. Gamma camera is mainly composed of collimator, detector, and signal processor. And the radiative source is namely the imaging object. The collimator is essential component of gamma camera system because the imaging performance of system is mainly dependent on the collimator. The performance evaluation of collimators can be done by using evaluating factors. In this study, the novel factors for gamma camera evaluation are suggested. The established evaluating factors by NEMA are FWHM, sensitivity, and uniformity. They have some limitations in spite of their usefulness. Firstly, performance evaluation by those factors give insensitive and indirect results only. Secondly, the evaluation of noise property is ambiguous. Thirdly, there is no synthetic evaluation of system performance. Simulation with Monte Carlo code and experiment with a small camera camera were simultaenuously performed to verify novel evaluating factors. For the evaluation of spatial resolution, MTF was applied instead of FWHM. The MTF values presents excellent linear relationship with FWHM values. The NNPS was applied instead of uniformity and sensitivity for the evaluation of noise fluctuation. The NNPS values also presents linear relationship with sensitivity and unifomity. Moreover, these novel factors give quantities as the function of spatial frequencies. Finally, the DQE values were given by calculations with MTF, NNPS, and input SNR. DQE effectively presents the synthetic evaluation of gamma camera performance. It is the conclusion that MTF, NNPS, and DQE can be novel evaluating factors for gamma camera systems and the new factor for synthetic evaluation is derived

  17. Dual photon absorptiometry for bone mineral measurements using a gamma camera

    International Nuclear Information System (INIS)

    Valkema, R.; Prpic, H.; Blokland, J.A.K.; Camps, J.A.J.; Papapoulos, S.E.; Bijvoet, O.L.M.; Pauwels, E.K.J.

    1994-01-01

    A gamma camera was equipped with a special collimator and arm assembly for bone mineral measurements with dual photon absorptiometry (DPA). The system was evaluated in vitro and in vivo and compared both with a rectilinear DPA and a dual energy X-ray (DEXA) system. All 3 systems showed a linear response in measurements of 4 vials, containing different amounts of hydroxyapatite. Phantom measurements with the gamma camera system showed a precision of 1.6% to 2.8%. Results obtained in 8 healthy volunteers with rectilinear and gamma camera systems were well correlated (R 2 = 0.78). With the photon beam directed from posterior to anterior, the separation of vertebrae was easy with the gamma camera system. We conclude that bone mineral measurements can be made with a gamma camera for assessment of fracture risk and in the decision process whether a patient needs treatment or not. For follow-up, the precision of DPA with a gamma camera is inadequate. (orig.)

  18. Small-animal SPECT and SPECT/CT: application in cardiovascular research

    Energy Technology Data Exchange (ETDEWEB)

    Golestani, Reza; Dierckx, Rudi A.J.O. [University Medical Center Groningen, Department of Nuclear Medicine and Molecular Imaging, Groningen (Netherlands); Wu, Chao [University Medical Center Groningen, Department of Nuclear Medicine and Molecular Imaging, Groningen (Netherlands); University Medical Center Utrecht, Image Sciences Institute and Rudolf Magnus Institute of Neurosciences, Utrecht (Netherlands); Tio, Rene A. [University Medical Center Groningen, Thorax Center, Department of Cardiology, Groningen (Netherlands); University Medical Center Groningen, Cardiovascular Imaging Group, P.O. Box 30001, Groningen (Netherlands); Zeebregts, Clark J. [University Medical Center Groningen, Department of Surgery, Division of Vascular Surgery, Groningen (Netherlands); University Medical Center Groningen, Cardiovascular Imaging Group, P.O. Box 30001, Groningen (Netherlands); Petrov, Artiom D. [University of California, Irvine, Division of Cardiology, School of Medicine, Irvine, California (United States); Beekman, Freek J. [University Medical Center Utrecht, Image Sciences Institute and Rudolf Magnus Institute of Neurosciences, Utrecht (Netherlands); Delft University of Technology, Faculty of Applied Sciences, Section Radiation Detection and Medical Imaging, Delft (Netherlands); MILabs, Utrecht (Netherlands); Boersma, Hendrikus H. [University Medical Center Groningen, Department of Nuclear Medicine and Molecular Imaging, Groningen (Netherlands); University Medical Center Groningen, Department of Clinical and Hospital Pharmacy, Hanzeplein 1, P.O. Box 30001, Groningen (Netherlands); University Medical Center Groningen, Cardiovascular Imaging Group, P.O. Box 30001, Groningen (Netherlands); Slart, Riemer H.J.A. [University Medical Center Groningen, Department of Nuclear Medicine and Molecular Imaging, Groningen (Netherlands); University Medical Center Groningen, Cardiovascular Imaging Group, P.O. Box 30001, Groningen (Netherlands)

    2010-09-15

    Preclinical cardiovascular research using noninvasive radionuclide and hybrid imaging systems has been extensively developed in recent years. Single photon emission computed tomography (SPECT) is based on the molecular tracer principle and is an established tool in noninvasive imaging. SPECT uses gamma cameras and collimators to form projection data that are used to estimate (dynamic) 3-D tracer distributions in vivo. Recent developments in multipinhole collimation and advanced image reconstruction have led to sub-millimetre and sub-half-millimetre resolution SPECT in rats and mice, respectively. In this article we review applications of microSPECT in cardiovascular research in which information about the function and pathology of the myocardium, vessels and neurons is obtained. We give examples on how diagnostic tracers, new therapeutic interventions, pre- and postcardiovascular event prognosis, and functional and pathophysiological heart conditions can be explored by microSPECT, using small-animal models of cardiovascular disease. (orig.)

  19. Small-animal SPECT and SPECT/CT: application in cardiovascular research

    International Nuclear Information System (INIS)

    Golestani, Reza; Dierckx, Rudi A.J.O.; Wu, Chao; Tio, Rene A.; Zeebregts, Clark J.; Petrov, Artiom D.; Beekman, Freek J.; Boersma, Hendrikus H.; Slart, Riemer H.J.A.

    2010-01-01

    Preclinical cardiovascular research using noninvasive radionuclide and hybrid imaging systems has been extensively developed in recent years. Single photon emission computed tomography (SPECT) is based on the molecular tracer principle and is an established tool in noninvasive imaging. SPECT uses gamma cameras and collimators to form projection data that are used to estimate (dynamic) 3-D tracer distributions in vivo. Recent developments in multipinhole collimation and advanced image reconstruction have led to sub-millimetre and sub-half-millimetre resolution SPECT in rats and mice, respectively. In this article we review applications of microSPECT in cardiovascular research in which information about the function and pathology of the myocardium, vessels and neurons is obtained. We give examples on how diagnostic tracers, new therapeutic interventions, pre- and postcardiovascular event prognosis, and functional and pathophysiological heart conditions can be explored by microSPECT, using small-animal models of cardiovascular disease. (orig.)

  20. Simulation-based evaluation and optimization of a new CdZnTe gamma-camera architecture (HiSens)

    International Nuclear Information System (INIS)

    Robert, Charlotte; Montemont, Guillaume; Rebuffel, Veronique; Guerin, Lucie; Verger, Loick; Buvat, Irene

    2010-01-01

    A new gamma-camera architecture named HiSens is presented and evaluated. It consists of a parallel hole collimator, a pixelated CdZnTe (CZT) detector associated with specific electronics for 3D localization and dedicated reconstruction algorithms. To gain in efficiency, a high aperture collimator is used. The spatial resolution is preserved thanks to accurate 3D localization of the interactions inside the detector based on a fine sampling of the CZT detector and on the depth of interaction information. The performance of this architecture is characterized using Monte Carlo simulations in both planar and tomographic modes. Detective quantum efficiency (DQE) computations are then used to optimize the collimator aperture. In planar mode, the simulations show that the fine CZT detector pixelization increases the system sensitivity by 2 compared to a standard Anger camera without loss in spatial resolution. These results are then validated against experimental data. In SPECT, Monte Carlo simulations confirm the merits of the HiSens architecture observed in planar imaging.

  1. Brain SPECT

    International Nuclear Information System (INIS)

    Feistel, H.

    1991-01-01

    Brain SPECT investigations have gained broad acceptance since the introduction of the lipophilic tracer Tc-99m-HMPAO. Depending on equipment and objectives in different departments, the examinations can be divided into three groups: 1. Under normal conditions and standardised patient preparation the 'rest' SPECT can be performed in every department with a tomographic camera. In cerebrovascular disease there is a demand for determination of either the perfusion reserve in reversible ischemia or prognostic values in completed stroke. In cases of dementia, SPECT may yield useful results according to differential diagnosis. Central cerebral system involvement in immunologic disease may be estimated with higher sensitivity than in conventional brain imaging procedures. In psychiatric diseases there is only a relative indication for brain SPECT, since results during recent years have been contradictory and may be derived only in interventional manner. In brain tumor diagnostics SPECT with Tl-201 possibly permits grading. In inflammatory disease, especially in viral encephalitis, SPECT may be used to obtain early diagnosis. Normal pressure hydrocephalus can be distinguished from other forms of dementia and, consequently, the necessity for shunting surgery can be recognised. 2. In departments equipped for emergency cases an 'acute' SPECT can be performed in illnesses with rapid changing symptoms such as different forms of migraine, transient global amnesia, epileptic seizures (so-called 'ictal SPECT') or urgent forms like trauma. 3. In cooperation with several departments brain SPECT can be practised as an interventional procedure in clinical and in scientific studies. (orig./MG) [de

  2. Experimental task-based optimization of a four-camera variable-pinhole small-animal SPECT system

    Science.gov (United States)

    Hesterman, Jacob Y.; Kupinski, Matthew A.; Furenlid, Lars R.; Wilson, Donald W.

    2005-04-01

    We have previously utilized lumpy object models and simulated imaging systems in conjunction with the ideal observer to compute figures of merit for hardware optimization. In this paper, we describe the development of methods and phantoms necessary to validate or experimentally carry out these optimizations. Our study was conducted on a four-camera small-animal SPECT system that employs interchangeable pinhole plates to operate under a variety of pinhole configurations and magnifications (representing optimizable system parameters). We developed a small-animal phantom capable of producing random backgrounds for each image sequence. The task chosen for the study was the detection of a 2mm diameter sphere within the phantom-generated random background. A total of 138 projection images were used, half of which included the signal. As our observer, we employed the channelized Hotelling observer (CHO) with Laguerre-Gauss channels. The signal-to-noise (SNR) of this observer was used to compare different system configurations. Results indicate agreement between experimental and simulated data with higher detectability rates found for multiple-camera, multiple-pinhole, and high-magnification systems, although it was found that mixtures of magnifications often outperform systems employing a single magnification. This work will serve as a basis for future studies pertaining to system hardware optimization.

  3. 131I activity quantification of gamma camera planar images

    Science.gov (United States)

    Barquero, Raquel; Garcia, Hugo P.; Incio, Monica G.; Minguez, Pablo; Cardenas, Alexander; Martínez, Daniel; Lassmann, Michael

    2017-02-01

    A procedure to estimate the activity in target tissues in patients during the therapeutic administration of 131I radiopharmaceutical treatment for thyroid conditions (hyperthyroidism and differentiated thyroid cancer) using a gamma camera (GC) with a high energy (HE) collimator, is proposed. Planar images are acquired for lesions of different sizes r, and at different distances d, in two HE GC systems. Defining a region of interest (ROI) on the image of size r, total counts n g are measured. Sensitivity S (cps MBq-1) in each acquisition is estimated as the product of the geometric G and the intrinsic efficiency η 0. The mean fluence of 364 keV photons arriving at the ROI per disintegration G, is calculated with the MCNPX code, simulating the entire GC and the HE collimator. Intrinsic efficiency η 0 is estimated from a calibration measurement of a plane reference source of 131I in air. Values of G and S for two GC systems—Philips Skylight and Siemens e-cam—are calculated. The total range of possible sensitivity values in thyroidal imaging in the e-cam and skylight GC measure from 7 cps MBq-1 to 35 cps MBq-1, and from 6 cps MBq-1 to 29 cps MBq-1, respectively. These sensitivity values have been verified with the SIMIND code, with good agreement between them. The results have been validated with experimental measurements in air, and in a medium with scatter and attenuation. The counts in the ROI can be produced by direct, scatter and penetration photons. The fluence value for direct photons is constant for any r and d values, but scatter and penetration photons show different values related to specific r and d values, resulting in the large sensitivity differences found. The sensitivity in thyroidal GC planar imaging is strongly dependent on uptake size, and distance from the GC. An individual value for the acquisition sensitivity of each lesion can significantly alleviate the level of uncertainty in the measurement of thyroid uptake activity for each patient.

  4. Gamma camera image acquisition, display, and processing with the personal microcomputer

    International Nuclear Information System (INIS)

    Lear, J.L.; Pratt, J.P.; Roberts, D.R.; Johnson, T.; Feyerabend, A.

    1990-01-01

    The authors evaluated the potential of a microcomputer for direct acquisition, display, and processing of gamma camera images. Boards for analog-to-digital conversion and image zooming were designed, constructed, and interfaced to the Macintosh II (Apple Computer, Cupertino, Calif). Software was written for processing of single, gated, and time series images. The system was connected to gamma cameras, and its performance was compared with that of dedicated nuclear medicine computers. Data could be acquired from gamma cameras at rates exceeding 200,000 counts per second, with spatial resolution exceeding intrinsic camera resolution. Clinical analysis could be rapidly performed. This system performed better than most dedicated nuclear medicine computers with respect to speed of data acquisition and spatial resolution of images while maintaining full compatibility with the standard image display, hard-copy, and networking formats. It could replace such dedicated systems in the near future as software is refined

  5. Geant4 simulation of a 3D high resolution gamma camera

    International Nuclear Information System (INIS)

    Akhdar, H.; Kezzar, K.; Aksouh, F.; Assemi, N.; AlGhamdi, S.; AlGarawi, M.; Gerl, J.

    2015-01-01

    The aim of this work is to develop a 3D gamma camera with high position resolution and sensitivity relying on both distance/absorption and Compton scattering techniques and without using any passive collimation. The proposed gamma camera is simulated in order to predict its performance using the full benefit of Geant4 features that allow the construction of the needed geometry of the detectors, have full control of the incident gamma particles and study the response of the detector in order to test the suggested geometries. Three different geometries are simulated and each configuration is tested with three different scintillation materials (LaBr3, LYSO and CeBr3)

  6. Development of a high sensitivity pinhole type gamma camera using semiconductors for low dose rate fields

    Science.gov (United States)

    Ueno, Yuichiro; Takahashi, Isao; Ishitsu, Takafumi; Tadokoro, Takahiro; Okada, Koichi; Nagumo, Yasushi; Fujishima, Yasutake; Yoshida, Akira; Umegaki, Kikuo

    2018-06-01

    We developed a pinhole type gamma camera, using a compact detector module of a pixelated CdTe semiconductor, which has suitable sensitivity and quantitative accuracy for low dose rate fields. In order to improve the sensitivity of the pinhole type semiconductor gamma camera, we adopted three methods: a signal processing method to set the discriminating level lower, a high sensitivity pinhole collimator and a smoothing image filter that improves the efficiency of the source identification. We tested basic performances of the developed gamma camera and carefully examined effects of the three methods. From the sensitivity test, we found that the effective sensitivity was about 21 times higher than that of the gamma camera for high dose rate fields which we had previously developed. We confirmed that the gamma camera had sufficient sensitivity and high quantitative accuracy; for example, a weak hot spot (0.9 μSv/h) around a tree root could be detected within 45 min in a low dose rate field test, and errors of measured dose rates with point sources were less than 7% in a dose rate accuracy test.

  7. SPECT and 123I-Iodolisuride (123-I-ILIS) in extra-pyramidal syndromes. The use of different models of γ-cameras

    International Nuclear Information System (INIS)

    Ribeiro, M.J.; Jannuario, C.; Santos, A.C.; Cunha, L.; Pedroso de Lima, J.J.; Prunier-Levilion, C.; Autret, A.; Guilloteau, D.; Besnard, J.C.; Baulieu, J.L.; Chassat, F.; Bekhechi, D.; Marchand, J.; Mauclaire, L.; Catela, L.

    1999-01-01

    The aim of this work was to evaluate 123 I-ILIS as a radioligand of dopamine receptors in patients with extra-pyramidal diseases by using different cameras in two different centers. 45 patients were included and divided in 2 groups: group I (n=28): idiopathic Parkinson disease, group II (n=17): other extra-pyramidal syndrome. 123 I-ILIS, 1.7 to 2.8 MBq/kg, was injected after informed consent. Imaging was performed with a single head camera, a dual head camera, a triple head camera and a brain dedicated annular detector. The pattern of the transverse slices containing the basal ganglia was classified according to 3 types: type 1: visible basal ganglia and invisible cortex, type 2: invisible basal ganglia and visible cortex, type 3: visible basal ganglia and cortex. Striatal/frontal cortex ratio (S/FC) was calculated from standardized, geometrical ROI's. No patient showed any undesirable effect. All SPECT images were interpretable. In group 1, 45/45 scintigraphic pattern were type 1 or 3, in group II 18/23 scintigraphic patterns were type 2 or 3. S/FC was significantly lower in group II than in group I patients. We conclude that 123 I-ILIS SPECT can be performed with any conventional γ-camera. It provides functional informations about the striatal dopaminergic synapse in patients with extra-pyramidal degenerative disease, and could be useful in the differential diagnosis between Parkinson disease and other extra-pyramidal syndromes. (author)

  8. Gamma camera computer system quality control for conventional and tomographic use

    International Nuclear Information System (INIS)

    Laird, E.E.; Allan, W.; Williams, E.D.

    1983-01-01

    The proposition that some of the proposed measurements of gamma camera performance parameters for routine quality control are redundant and that only the uniformity requires daily monitoring was examined. To test this proposition, measurements of gamma camera performance were carried out under normal operating conditions and also with the introduction of faults (offset window, offset PM tube). Results for the uniform flood field are presented for non-uniformity, intrinsic spatial resolution, linearity and relative system sensitivity. The response to introduced faults revealed that while the non-uniformity response pattern of the gamma camera was clearly affected, both measurements and qualitative indications of the other performance parameters did not necessarily show any deterioration. (U.K.)

  9. Utilization of a gamma camera in research of the concentration in marine products

    International Nuclear Information System (INIS)

    Nakamura, Ryoichi

    1981-01-01

    A gamma camera was used for the study of the metabolism of micro elements in marine products. Hexagrammos otakii (rock trout) was put under anesthesia with MS-222. By cutting partly the abdomen, the internal organs were exposed. 1 - 2 mCi of technetium-99m was injected into the bulbus arteriosus. From immediately after the injection, photographs were taken consecutively, one picture every 0.5 second for 30 seconds, to a total of 60 pictures. Since the gamma camera has been developed solely for human beings, there is some inconvenience when it is applied to marine products. The advantages of using a gamma camera are the observation on the behavior of substances in a body while a marine product is alive, and the grasping of the variation in substance behavior at extremely brief intervals. The disadvantages are the low resolution of about 5 mm - 7 mm, and the difficulty in differentiating overlapping organs. (J.P.N.)

  10. Camera Concepts for the Advanced Gamma-Ray Imaging System (AGIS)

    Science.gov (United States)

    Nepomuk Otte, Adam

    2009-05-01

    The Advanced Gamma-Ray Imaging System (AGIS) is a concept for the next generation observatory in ground-based very high energy gamma-ray astronomy. Design goals are ten times better sensitivity, higher angular resolution, and a lower energy threshold than existing Cherenkov telescopes. Each telescope is equipped with a camera that detects and records the Cherenkov-light flashes from air showers. The camera is comprised of a pixelated focal plane of blue sensitive and fast (nanosecond) photon detectors that detect the photon signal and convert it into an electrical one. The incorporation of trigger electronics and signal digitization into the camera are under study. Given the size of AGIS, the camera must be reliable, robust, and cost effective. We are investigating several directions that include innovative technologies such as Geiger-mode avalanche-photodiodes as a possible detector and switched capacitor arrays for the digitization.

  11. Fully integrated digital GAMMA camera-computer system

    International Nuclear Information System (INIS)

    Berger, H.J.; Eisner, R.L.; Gober, A.; Plankey, M.; Fajman, W.

    1985-01-01

    Although most of the new non-nuclear imaging techniques are fully digital, there has been a reluctance in nuclear medicine to abandon traditional analog planar imaging in favor of digital acquisition and display. The authors evaluated a prototype digital camera system (GE STARCAM) in which all of the analog acquisition components are replaced by microprocessor controls and digital circuitry. To compare the relative effects of acquisition matrix size on image quality and to ascertain whether digital techniques could be used in place of analog imaging, Tc-99m bone scans were obtained on this digital system and on a comparable analog camera in 10 patients. The dedicated computer is used for camera setup including definition of the energy window, spatial energy correction, and spatial distortion correction. The display monitor, which is used for patient positioning and image analysis, is 512/sup 2/ non-interlaced, allowing high resolution imaging. Data acquisition and processing can be performed simultaneously. Thus, the development of a fully integrated digital camera-computer system with optimized display should allow routine utilization of non-analog studies in nuclear medicine and the ultimate establishment of fully digital nuclear imaging laboratories

  12. Patient restraining device for the pinhole collimator and gamma scintillation camera

    International Nuclear Information System (INIS)

    Kay, T.D.

    1977-01-01

    A patient restraining device for use with the pinhole collimator of a conventional Gamma Scintillation Camera, the restraining device being made of an adapter ring and a patient holder. The adapter ring is secured directly to the pinhole collimator while the holder is adjustably mounted on the adapter. The adapter ring is so designed to accommodate a variety of holders so as to enable the scanning of many different areas of a patient's anatomy by the scintillation camera

  13. A technique for the absolute measurement of activity using a gamma camera and computer

    International Nuclear Information System (INIS)

    Fleming, J.S.

    1979-01-01

    The quantity of activity of an isotope in an organ is of interest in gamma camera studies. There are problems in correcting the regional gamma camera counts for varying absorption in body tissue, particularly for thick organs. A description is given of a general method, based on anterior, posterior and lateral views. The method has been applied to liver 99 Tcsup(m) sulphur colloid imaging. Phantom measurements showed that the smallest error to be expected was 3.2%. In practice errors would be 5 to 10%, although lower errors would be associated with estimates of liver/spleen ratios. (U.K.)

  14. Bullet scintigraphy: can gamma camera be used for depleted uranium accident measurements?

    International Nuclear Information System (INIS)

    Spaic, R.; Markovic, S.; Pavlovic, S.; Radic, Z.; Pavlovic, R.; Ajdinovic, B.; Baskot, B.; Djurovic, B.

    2002-01-01

    The aim of this study was to see could gamma cameras be used for measurement of internal contamination with depleted uranium. Radioactive waste depleted uranium, which is by-product from the production of enriched fuel for nuclear rectors and weapons now, is used for manufacture bullets, which are used in Iraq, Republic of Srpska and Yugoslavia. In this paper is measured minimum detectable activity (MDA) of gamma cameras for depleted uranium, iodine and technetium. For detection of the depleted uranium are used low energy X-rays, energy of 100 keV with 20% windows width. About 40% of gamma emissions of the depleted uranium are in these limits. Measured MDA activities 50-100 Bq for depleted uranium, iodine and technetium are about then times more then same for WBC (5 Bq). Gamma cameras can be used for relatively measurement of depleted uranium activity, what can be used for absorbed dose estimation. Detection of low level internal contamination with depleted uranium can be done with gamma cameras. (authors)

  15. Development of the neutron filters for JET gamma-ray cameras

    International Nuclear Information System (INIS)

    Soare, S.; Curuia, M.; Anghel, M.; Constantin, M.; David, E.; Kiptily, V.; Prior, P.; Edlington, T.; Griph, S.; Krivchenkov, Y.; Popovichev, S.; Riccardo, V.; Syme, B; Thompson, V.; Murari, A.; Zoita, V.; Bonheure, G.; Le Guern

    2007-01-01

    The JET gamma-ray camera diagnostics have already provided valuable information on the gamma-ray imaging of fast ion evaluation in JET plasmas. The JET Gamma-Ray Cameras (GRC) upgrade project deals with the design of appropriate neutron/gamma-ray filters ('neutron attenuaters').The main design parameter was the neutron attenuation factor. The two design solutions, that have been finally chosen and developed at the level of scheme design, consist of: a) one quasi-crescent shaped neutron attenuator (for the horizontal camera) and b) two quasi-trapezoid shaped neutron attenuators (for the vertical one). Various neutron-attenuating materials have been considered (lithium hydride with natural isotopic composition and 6 Li enriched, light and heavy water, polyethylene). Pure light water was finally chosen as the attenuating material for the JET gamma-ray cameras. FEA methods used to evaluate the behaviour of the filter casings under the loadings (internal hydrostatic pressure, torques) have proven the stability of the structure. (authors)

  16. The added value of a portable gamma camera for intraoperative detection of sentinel lymph node in squamous cell carcinoma of the oral cavity: A case report.

    Science.gov (United States)

    Mayoral, M; Paredes, P; Sieira, R; Vidal-Sicart, S; Marti, C; Pons, F

    2014-01-01

    The use of sentinel lymph node biopsy in squamous cell carcinoma of the oral cavity is still subject to debate although some studies have reported its feasibility. The main reason for this debate is probably due to the high false-negative rate for floor-of-mouth tumors per se. We report the case of a 54-year-old man with a T1N0 floor-of-mouth squamous cell carcinoma who underwent the sentinel lymph node procedure. Lymphoscintigraphy and SPECT/CT imaging were performed for lymphatic mapping with a conventional gamma camera. Sentinel lymph nodes were identified at right Ib, left IIa and Ia levels. However, these sentinel lymph nodes were difficult to detect intraoperatively with a gamma probe owing to the activity originating from the injection site. The use of a portable gamma camera made it possible to localize and excise all the sentinel lymph nodes. This case demonstrates the usefulness of this tool to improve sentinel lymph node detecting in floor-of-mouth tumors, especially those close to the injection area. Copyright © 2013 Elsevier España, S.L. and SEMNIM. All rights reserved.

  17. Performance characteristics of ZLC 37 Siemens gamma camera

    International Nuclear Information System (INIS)

    Abdelgadir, Wafaa Abdelrahman

    1994-04-01

    The relationships between the ZLC 37 Siemens γ camera parameters (energy resolution, plane sensitivity, intrinsic uniformity, intrinsic resolution, system uniformity and system resolution) and diagnostic imaging performance was investigated. These parameters when computers when compared with internationally published data showed that the ZLC 37 Siemens γ cameras is in good operative conditions. The effect of the scattering media and WW on the spatial resolution, when the distance is kept fixed were investigated. Comparison of resolution for the media (air, water, water + radioactivity when using WW (10, 15,20%) showed that the resolution is best for air, better for water and worse for water + radioactivity up to a concentration of 8% for a 10% WW. (Author)

  18. A Compton camera prototype for prompt gamma medical imaging

    Directory of Open Access Journals (Sweden)

    Thirolf P.G.

    2016-01-01

    Full Text Available Compton camera prototype for a position-sensitive detection of prompt γ rays from proton-induced nuclear reactions is being developed in Garching. The detector system allows to track the Comptonscattered electrons. The camera consists of a monolithic LaBr3:Ce scintillation absorber crystal, read out by a multi-anode PMT, preceded by a stacked array of 6 double-sided silicon strip detectors acting as scatterers. The LaBr3:Ce crystal has been characterized with radioactive sources. Online commissioning measurements were performed with a pulsed deuteron beam at the Garching Tandem accelerator and with a clinical proton beam at the OncoRay facility in Dresden. The determination of the interaction point of the photons in the monolithic crystal was investigated.

  19. An Imaging Camera for Biomedical Application Based on Compton Scattering of Gamma Rays

    OpenAIRE

    Fontana, Cristiano Lino

    2013-01-01

    In this thesis we present the R&D of a Compton Camera (CC) for small object imaging. The CC concept requires two detectors to obtain the incoming direction of the gamma ray. This approach, sometimes named ``Electronic Collimation,'' differs from the usual technique that employs collimators for physically selecting gamma-rays of a given direction. This solution offers the advantage of much greater sensitivity and hence smaller doses. We propose a novel design, which uses two simila...

  20. A study of full width at half maximum (FWHM) according to the filter's cut off level in SPECT camera

    Energy Technology Data Exchange (ETDEWEB)

    Park, Soung Ock [Dongnam Health College, Suwon (Korea, Republic of); Kwon, Soo Il [Kyonggi University, Suwon (Korea, Republic of)

    2003-06-15

    Filtering is necessary to reduce statistical noise and to increase image quality in SPECT images. Noises controlled by low-pass filter designed to suppress high spatial frequency in SPECT image. Most SPECT filter function control the degree of high frequency suppression by choosing a cut off frequency. The location of cut off frequency determines the affect image noise and spatial resolution. If select the low cut off frequency, its provide good noise suppression but insufficient image quantity and high cut off frequencies increase the image resolution but insufficient noise suppression. The purpose of this study was to determines the optimum cut off level with comparison of FWHM according to cut off level in each filters-Band-limited, Sheep-logan, Sheep-logan Hanning, Generalized Hamming, Low pass cosine, Parazen and Butterworth filter in SPECT camera. We recorded image along the X, Y, Z-axis with {sup 99m}TcO{sub 4} point source and measured FWHM by use profile curve. We find averaged length is 9.16 mm {approx} 18.14 mm of FWHM in X, Y, and Z-axis, and Band-limited and Generalized Hamming filters measures 9.16 mm at 0.7 cycle/pixel cut off frequency.

  1. High-resolution single photon planar and spect imaging of brain and neck employing a system of two co-registered opposed gamma imaging heads

    Science.gov (United States)

    Majewski, Stanislaw [Yorktown, VA; Proffitt, James [Newport News, VA

    2011-12-06

    A compact, mobile, dedicated SPECT brain imager that can be easily moved to the patient to provide in-situ imaging, especially when the patient cannot be moved to the Nuclear Medicine imaging center. As a result of the widespread availability of single photon labeled biomarkers, the SPECT brain imager can be used in many locations, including remote locations away from medical centers. The SPECT imager improves the detection of gamma emission from the patient's head and neck area with a large field of view. Two identical lightweight gamma imaging detector heads are mounted to a rotating gantry and precisely mechanically co-registered to each other at 180 degrees. A unique imaging algorithm combines the co-registered images from the detector heads and provides several SPECT tomographic reconstructions of the imaged object thereby improving the diagnostic quality especially in the case of imaging requiring higher spatial resolution and sensitivity at the same time.

  2. Contralateral thalamic hypoperfusion on brain perfusion SPECT

    International Nuclear Information System (INIS)

    Lee, Seok Mo; Bae, Sang Kyun; Yoo, Kyung Moo; Yum, Ha Yong

    2000-01-01

    Brain perfusion single photon emission computed tomography (SPECT) is useful for the localization of cerebrovascular lesion and sometimes reveals more definite lesion than radiologic imaging modality such as CT or MRI does. The purpose of this study was to evaluate the diagnostic usefulness of brain perfusion SPECT in patients with hemisensory impairment. Thirteen consecutive patients (M:F= 8:5, mean age = 48) who has hemisensory impairment were included. Brain perfusion SPECT was performed after intravenous injection of 1110 MBq of Tc-99m ECD. The images were obtained using a dual-head gamma camera with ultra-high resolution collimator. Semiquantitative analysis was performed after placing multiple ROIs on cerebral cortex, basal ganglia, thalamus and cerebellum. There were 10 patients with left hemisensory impairment and 3 patients with right-sided symptom. Only 2 patients revealed abnormal signal change in the thalamus on MRI. But brain perfusion SPECT showed decreased perfusion in the thalamus in 9 patients. Six patients among 10 patients with left hemisensory impairment revealed decreased perfusion in the contralateral thalamus on brain SPECT. The other 4 patients revealed no abnormality. Two patients among 3 patients with right hemisensory impairment also showed decreased perfusion in the contralateral thalamus on brain SPECT. One patients with right hemisensory impairment showed ipsilateral perfusion decrease. Two patients who had follow-up brain perfusion SEPCT after treatment revealed normalization of perfusion in the thalamus. Brain perfusion SPECT might be a useful tool in diagnosing patients with hemisensory impairment

  3. Performance tests of two portable mini gamma cameras for medical applications

    International Nuclear Information System (INIS)

    Sanchez, F.; Fernandez, M. M.; Gimenez, M.; Benlloch, J. M.; Rodriguez-Alvarez, M. J.; Garcia de Quiros, F.; Lerche, Ch. W.; Pavon, N.; Palazon, J. A.; Martinez, J.; Sebastia, A.

    2006-01-01

    We have developed two prototypes of portable gamma cameras for medical applications based on a previous prototype designed and tested by our group. These cameras use a CsI(Na) continuous scintillation crystal coupled to the new flat-panel-type multianode position-sensitive photomultiplier tube, H8500 from Hamamatsu Photonics. One of the prototypes, mainly intended for intrasurgical use, has a field of view of 44x44 mm 2 , and weighs 1.2 kg. Its intrinsic resolution is better than 1.5 mm and its energy resolution is about 13% at 140 keV. The second prototype, mainly intended for osteological, renal, mammary, and endocrine (thyroid, parathyroid, and suprarenal) scintigraphies, weighs a total of 2 kg. Its average spatial resolution is 2 mm; it has a field of view of 95x95 mm 2 , with an energy resolution of about 15% at 140 keV. The main advantages of these gamma camera prototypes with respect to those previously reported in the literature are high portability and low weight, with no significant loss of sensitivity and spatial resolution. All the electronic components are packed inside the mini gamma cameras, and no external electronic devices are required. The cameras are only connected through the universal serial bus port to a portable PC. In this paper, we present the design of the cameras and describe the procedures that have led us to choose their configuration together with the most important performance features of the cameras. For one of the prototypes, clinical tests on melanoma patients are presented and images are compared with those obtained with a conventional camera

  4. Affordable CZT SPECT with dose-time minimization (Conference Presentation)

    Science.gov (United States)

    Hugg, James W.; Harris, Brian W.; Radley, Ian

    2017-03-01

    PURPOSE Pixelated CdZnTe (CZT) detector arrays are used in molecular imaging applications that can enable precision medicine, including small-animal SPECT, cardiac SPECT, molecular breast imaging (MBI), and general purpose SPECT. The interplay of gamma camera, collimator, gantry motion, and image reconstruction determines image quality and dose-time-FOV tradeoffs. Both dose and exam time can be minimized without compromising diagnostic content. METHODS Integration of pixelated CZT detectors with advanced ASICs and readout electronics improves system performance. Because historically CZT was expensive, the first clinical applications were limited to small FOV. Radiation doses were initially high and exam times long. Advances have significantly improved efficiency of CZT-based molecular imaging systems and the cost has steadily declined. We have built a general purpose SPECT system using our 40 cm x 53 cm CZT gamma camera with 2 mm pixel pitch and characterized system performance. RESULTS Compared to NaI scintillator gamma cameras: intrinsic spatial resolution improved from 3.8 mm to 2.0 mm; energy resolution improved from 9.8% to reconstruction, result in minimized dose and exam time. With CZT cost improving, affordable whole-body CZT general purpose SPECT is expected to enable precision medicine applications.

  5. Defective organification of iodine in an infant demonstrated with 123J and gamma camera

    International Nuclear Information System (INIS)

    Goebel, R.; Leb, G.; Sulzer, M.; Graz Univ.

    1979-01-01

    A defective organification of iodine is demonstrated in a two year old male infant. The availability and a relatively simple radiation detector and storage system (gamma camera and 1600 word memory) gives a reasonable low radiation dose, allows correction for extrathyroid neck activity and obviates problems of collimation. (orig.) [de

  6. Gastric emptying of liquid meals: validation of the gamma camera technique

    Energy Technology Data Exchange (ETDEWEB)

    Lawaetz, Otto; Dige-Petersen, Harriet

    1989-05-01

    To assess the extent of errors and to provide correction factors for gamma camera gastric emptying studies of liquid meals labelled with radionuclides (/sup 99/Tc/sup m/ or /sup 113/In/sup m/), phantom studies were performed with different gastric emptying procedures, gamma cameras and data handling systems. To validate the overall accuracy of the method, 24 combined aspiration and gamma camera gastric emptying studies were carried out in three normal volunteers. Gastric meal volume was underestimated due to scattered radiation from the stomach. The underestimation was 7-20% varying with the size of the gastric region of interest (ROI), the energy of the nuclide and the fraction of meal in the stomach. The overestimation, due to scattered radiation from the gut, was negligible (1-3%) for any of the procedures. The gamma camera technique eliminated much of the error due to variations of stomach geometry and produced accurate quantitative gastric emptying data comparable to those obtained by evacuation (P > 0.10), when the entire field maximum 1-min count achieved within the first 20 min of a study was taken as representing the original volume of the meal ingested, and when corrections for area related errors due to scattered radiation from the stomach were performed. (author).

  7. Gamma camera with an original system of scintigraphic image printing incorporated

    International Nuclear Information System (INIS)

    Roux, G.

    A new gamma camera has been developed, using Anger's Principle to localise the scintillations and incorporating the latest improvements which give a standard of efficiency at present competitive for this kind of apparatus. In the general design of the system special care was devoted to its ease of employment and above all to the production of high-quality scintigraphic images, the recording of images obtained from the gamma camera posing a problem to which a solution is proposed. This consists in storing all the constituent data of an image in a cell matrix of format similar to the scope of the object, the superficial information density of the image being represented by the cell contents. When the examination is finished a special printer supplies a 35x43 cm 2 document in colour on paper, or in black and white on radiological film, at 2:1 or 1:1 magnifications. The laws of contrast representation by the colours or shades of grey are chosen a posteriori according to the organ examined. Documents of the same quality as those so far supplied by a rectilinear scintigraph are then obtained with the gamma camera, which offers its own advantages in addition. The first images acquired in vivo with the whole system, gamma camera plus printer, are presented [fr

  8. Characteristics of a single photon emission tomography system with a wide field gamma camera

    International Nuclear Information System (INIS)

    Mathonnat, F.; Soussaline, F.; Todd-Pokropek, A.E.; Kellershohn, C.

    1979-01-01

    This text summarizes a work study describing the imagery possibilities of a single photon emission tomography system composed of a conventional wide field gamma camera, connected to a computer. The encouraging results achieved on the various phantoms studied suggest a significant development of this technique in clinical work in Nuclear Medicine Departments [fr

  9. A study on the optimization of optical guide of gamma camera detector

    International Nuclear Information System (INIS)

    Chung, Yong Hyun; Cho, Gyu Seong; Kim, Ho Kyung; Lee, Wan No; Kim, Young Soo

    2000-01-01

    An optical guide, which is a light guide located between NaI(Tl) scintillation-crystal and array of photo-multiplier tubes (PMTs) in the gamma camera detector system, is an essential component to deliver the spatial information recorded in scintillator to the PMTs. Without the optical guide, the spatial information within the range of a single PMT could not be obtained. For the design of the optimal optical guide, it is necessary to characterize its properties, especially sensitivity and spatial resolution of detector. In this study, the thickness and the refractive index of optical guide, which affect not only on the sensitivity but also on the spatial resolution of gamma-camera detector, were investigated by using Monte Carlo simulation. A 12'x12'x3/8' NaI(Tl) and 23 PMTs with each 5' diameter were considered as a gamma-camera detector components. Interactions of optical photons in the scintillator and the optical guide were simulated using a commercial code DETECT97, and the spatial resolution, mainly interfered by the intrinsic inward distortion within the PMT, was investigated using our own ANGER program, which was developed to calculate positions of incident photons in the gamma camera. From the simulation results, it was found that an optical guide with 1.6 of refractive index and 10 mm of thickness give maximum sensitivity and minimum spatial distortion, respectively

  10. Clinical utility of 18-FDG-PET with a modified SPECT-camera using molecular coincidence detection in oncology

    International Nuclear Information System (INIS)

    Gabriel, M. F.

    1998-09-01

    Malignant diseases are belonging to one of the most frequent reasons for mortality and morbidity of people in industrialized countries. In order to avoid inadequate therapy such as unnecessary operations etc. accurate diagnostic techniques are needed to assess malignancy of proven lesions, for staging of cancer or to assess success of therapy. Many studies have reported the value of PET in such cases. Because of limited financial resources we started PET with a Dual-head-SPECT-camera modified with a MCD-module in February 1997 in order to obtain quick access to clinical 18-FDG studies. The aim of this work was to compare the results of our system with reports of the so called 'state of the art'-PET and with other diagnostic techniques used in clinical oncology. So far 124 studies were performed with the MCD-mode using a standardized investigation protocol between February 1997 and May 1998. The applied dose of 18-FDG for oncological studies was about 185 MBq. The tracer was supplied from the radio-pharmaceutical unit of the Department of Nuclear Medicine, Klinikum Rechts der Isar, Technische Universitaet Muenchen. The obtained results were carefully compared with CT, MRI and conventional radiology. In addition, the final diagnosis (based on histology, surgical reports, autopsy and follow up) was also considered. Oncological studies were done either to assess malignancy in certain lesions (n = 25), for staging cancer (n = 77), or to assess success of therapy (n = 22). Sensitivity and specificity for all oncological cases were 99 % and 89 % respectively. One false negative scan was a pretreated CNS-lymphoma, where false positive studies were due to inflammation. (author)

  11. A versatile calibration procedure for portable coded aperture gamma cameras and RGB-D sensors

    Science.gov (United States)

    Paradiso, V.; Crivellaro, A.; Amgarou, K.; de Lanaute, N. Blanc; Fua, P.; Liénard, E.

    2018-04-01

    The present paper proposes a versatile procedure for the geometrical calibration of coded aperture gamma cameras and RGB-D depth sensors, using only one radioactive point source and a simple experimental set-up. Calibration data is then used for accurately aligning radiation images retrieved by means of the γ-camera with the respective depth images computed with the RGB-D sensor. The system resulting from such a combination is thus able to retrieve, automatically, the distance of radioactive hotspots by means of pixel-wise mapping between gamma and depth images. This procedure is of great interest for a wide number of applications, ranging from precise automatic estimation of the shape and distance of radioactive objects to Augmented Reality systems. Incidentally, the corresponding results validated the choice of a perspective design model for a coded aperture γ-camera.

  12. Development and evaluation of a portable CZT coded aperture gamma-camera

    Energy Technology Data Exchange (ETDEWEB)

    Montemont, G.; Monnet, O.; Stanchina, S.; Maingault, L.; Verger, L. [CEA, LETI, Minatec Campus, Univ. Grenoble Alpes, 38054 Grenoble, (France); Carrel, F.; Lemaire, H.; Schoepff, V. [CEA, LIST, 91191 Gif-sur-Yvette, (France); Ferrand, G.; Lalleman, A.-S. [CEA, DAM, DIF, 91297 Arpajon, (France)

    2015-07-01

    We present the design and the evaluation of a CdZnTe (CZT) based gamma camera using a coded aperture mask. This camera, based on a 8 cm{sup 3} detection module, is small enough to be portable and battery-powered (4 kg weight and 4 W power dissipation). As the detector has spectral capabilities, the gamma camera allows isotope identification and colored imaging, by affecting one color channel to each identified isotope. As all data processing is done at real time, the user can directly observe the outcome of an acquisition and can immediately react to what he sees. We first present the architecture of the system, how the detector works, and its performances. After, we focus on the imaging technique used and its strengths and limitations. Finally, results concerning sensitivity, spatial resolution, field of view and multi-isotope imaging are shown and discussed. (authors)

  13. Development and evaluation of a portable CZT coded aperture gamma-camera

    International Nuclear Information System (INIS)

    Montemont, G.; Monnet, O.; Stanchina, S.; Maingault, L.; Verger, L.; Carrel, F.; Lemaire, H.; Schoepff, V.; Ferrand, G.; Lalleman, A.-S.

    2015-01-01

    We present the design and the evaluation of a CdZnTe (CZT) based gamma camera using a coded aperture mask. This camera, based on a 8 cm 3 detection module, is small enough to be portable and battery-powered (4 kg weight and 4 W power dissipation). As the detector has spectral capabilities, the gamma camera allows isotope identification and colored imaging, by affecting one color channel to each identified isotope. As all data processing is done at real time, the user can directly observe the outcome of an acquisition and can immediately react to what he sees. We first present the architecture of the system, how the detector works, and its performances. After, we focus on the imaging technique used and its strengths and limitations. Finally, results concerning sensitivity, spatial resolution, field of view and multi-isotope imaging are shown and discussed. (authors)

  14. A protocol for the calibration of gamma cameras to estimate internal contamination in emergency situations

    International Nuclear Information System (INIS)

    Dantas, B.M.; Lucena, E.A.; Dantas, A.L.A.; Araujo, F.; Melo, D.; Rebelo, A.M.O.; Teran, M.; Paolino, A.; Hermida, J.C.; Rojo, A.M.; Puerta, J.A.; Morales, J.; Bejerano, G.M.L.; Alfaro, M.; Ruiz, M.A.; Videla, R.; Pinones, O.; Gonzalez, S.; Navarro, T.; Cruz-Suarez, R.

    2007-01-01

    The concern about accidents involving radioactive materials has led to the search of alternative methods to quickly identify and quantify radionuclides in workers and in the population. One of the options to face up an eventual demand for mass monitoring of internal contamination is the use of a nuclear medicine diagnostic equipment known as gamma camera, a device used to scan patients who have been administered specific amounts of radioactive materials for medical purposes. Although the gamma camera is used for image diagnosis, it can be calibrated with anthropomorphic phantoms or point sources for the quantification of radionuclide activities in the human body. This work presents a protocol for the calibration of gamma cameras for such application. In order to evaluate the suitability of this type of equipment, a gamma camera available in a public hospital located in Rio de Janeiro was calibrated for the in vivo measurement of 131 I. The calibration includes the determination of detection efficiencies and minimum detectable activities for each radionuclide. The results show that the gamma camera presents enough sensitivity to detect activity levels corresponding to effective doses below 1 mSv. The protocol is the basis to establish a network of Nuclear Medicine Centres, located in public hospitals in eight countries of Latin America (Argentina, Brazil, Colombia, Cuba, Chile, Mexico, Peru and Uruguay) and in Spain that could be requested to collaborate in remediation actions in the event of an accident involving incorporation of radioactive materials. This protocol is one of the most significant outputs of the IAEA-ARCAL Project (RLA/9/049-LXXVIII) aimed to the Harmonization of Internal Dosimetry Procedures. (authors)

  15. A protocol for the calibration of gamma cameras to estimate internal contamination in emergency situations

    Energy Technology Data Exchange (ETDEWEB)

    Dantas, B.M.; Lucena, E.A.; Dantas, A.L.A.; Araujo, F.; Melo, D. [Instituto de Radioprotecao e Dosimetria, CNEN, Av. Salvador Allende s/n, Rio de Janeiro (Brazil); Rebelo, A.M.O. [University Hospital, Nuclear Medicine Center, Rio de Janeiro (Brazil); Teran, M.; Paolino, A. [Facultad de Quimica, Montevideo (Uruguay); Hermida, J.C. [Hospital de Clinicas, Facultad de Medicina, Montevideo (Uruguay); Rojo, A.M. [Autoridad Regulatoria Nuclear, Buenos Aires (Argentina); Puerta, J.A.; Morales, J. [Universidad Nacional de Colombia, Medellin (Colombia); Bejerano, G.M.L. [Centro de Proteccion e Higiene de las Radiaciones, Ciudad de la Habana (Cuba); Alfaro, M.; Ruiz, M.A. [Instituto Nacional de Investigaciones Nucleares, Ocoyoacac (Mexico); Videla, R.; Pinones, O. [Comision Chilena de Energia Nuclear, Santiago (Chile); Gonzalez, S. [Instituto Peruano de Energia Nuclear, Lima (Peru); Navarro, T. [Centro de Investigaciones Energeticas, Medioambientales y Tecnologicas, Madrid (Spain); Cruz-Suarez, R. [International Atomic Energy Agency, Vienna (Austria)

    2007-07-01

    The concern about accidents involving radioactive materials has led to the search of alternative methods to quickly identify and quantify radionuclides in workers and in the population. One of the options to face up an eventual demand for mass monitoring of internal contamination is the use of a nuclear medicine diagnostic equipment known as gamma camera, a device used to scan patients who have been administered specific amounts of radioactive materials for medical purposes. Although the gamma camera is used for image diagnosis, it can be calibrated with anthropomorphic phantoms or point sources for the quantification of radionuclide activities in the human body. This work presents a protocol for the calibration of gamma cameras for such application. In order to evaluate the suitability of this type of equipment, a gamma camera available in a public hospital located in Rio de Janeiro was calibrated for the in vivo measurement of {sup 131}I. The calibration includes the determination of detection efficiencies and minimum detectable activities for each radionuclide. The results show that the gamma camera presents enough sensitivity to detect activity levels corresponding to effective doses below 1 mSv. The protocol is the basis to establish a network of Nuclear Medicine Centres, located in public hospitals in eight countries of Latin America (Argentina, Brazil, Colombia, Cuba, Chile, Mexico, Peru and Uruguay) and in Spain that could be requested to collaborate in remediation actions in the event of an accident involving incorporation of radioactive materials. This protocol is one of the most significant outputs of the IAEA-ARCAL Project (RLA/9/049-LXXVIII) aimed to the Harmonization of Internal Dosimetry Procedures. (authors)

  16. SU-E-E-06: Teaching About the Gamma Camera and Ultrasound Imaging

    Energy Technology Data Exchange (ETDEWEB)

    Lowe, M; Spiro, A [Loyola University Maryland, Baltimore, Maryland (United States); Vogel, R [Iowa Doppler Products, Iowa City, Iowa (United States); Donaldson, N; Gosselin, C [Rockhurst University, Kansas City, MO (United States)

    2015-06-15

    Purpose: Instructional modules on applications of physics in medicine are being developed. The target audience consists of students who have had an introductory undergraduate physics course. This presentation will concentrate on an active learning approach to teach the principles of the gamma camera. There will also be a description of an apparatus to teach ultrasound imaging. Methods: Since a real gamma camera is not feasible in the undergraduate classroom, we have developed two types of optical apparatus that teach the main principles. To understand the collimator, LEDS mimic gamma emitters in the body, and the photons pass through an array of tubes. The distance, spacing, diameter, and length of the tubes can be varied to understand the effect upon the resolution of the image. To determine the positions of the gamma emitters, a second apparatus uses a movable green laser, fluorescent plastic in lieu of the scintillation crystal, acrylic rods that mimic the PMTs, and a photodetector to measure the intensity. The position of the laser is calculated with a centroid algorithm.To teach the principles of ultrasound imaging, we are using the sound head and pulser box of an educational product, variable gain amplifier, rotation table, digital oscilloscope, Matlab software, and phantoms. Results: Gamma camera curriculum materials have been implemented in the classroom at Loyola in 2014 and 2015. Written work shows good knowledge retention and a more complete understanding of the material. Preliminary ultrasound imaging materials were run in 2015. Conclusion: Active learning methods add another dimension to descriptions in textbooks and are effective in keeping the students engaged during class time. The teaching apparatus for the gamma camera and ultrasound imaging can be expanded to include more cases, and could potentially improve students’ understanding of artifacts and distortions in the images.

  17. SU-E-E-06: Teaching About the Gamma Camera and Ultrasound Imaging

    International Nuclear Information System (INIS)

    Lowe, M; Spiro, A; Vogel, R; Donaldson, N; Gosselin, C

    2015-01-01

    Purpose: Instructional modules on applications of physics in medicine are being developed. The target audience consists of students who have had an introductory undergraduate physics course. This presentation will concentrate on an active learning approach to teach the principles of the gamma camera. There will also be a description of an apparatus to teach ultrasound imaging. Methods: Since a real gamma camera is not feasible in the undergraduate classroom, we have developed two types of optical apparatus that teach the main principles. To understand the collimator, LEDS mimic gamma emitters in the body, and the photons pass through an array of tubes. The distance, spacing, diameter, and length of the tubes can be varied to understand the effect upon the resolution of the image. To determine the positions of the gamma emitters, a second apparatus uses a movable green laser, fluorescent plastic in lieu of the scintillation crystal, acrylic rods that mimic the PMTs, and a photodetector to measure the intensity. The position of the laser is calculated with a centroid algorithm.To teach the principles of ultrasound imaging, we are using the sound head and pulser box of an educational product, variable gain amplifier, rotation table, digital oscilloscope, Matlab software, and phantoms. Results: Gamma camera curriculum materials have been implemented in the classroom at Loyola in 2014 and 2015. Written work shows good knowledge retention and a more complete understanding of the material. Preliminary ultrasound imaging materials were run in 2015. Conclusion: Active learning methods add another dimension to descriptions in textbooks and are effective in keeping the students engaged during class time. The teaching apparatus for the gamma camera and ultrasound imaging can be expanded to include more cases, and could potentially improve students’ understanding of artifacts and distortions in the images

  18. Annihilation gamma ray background characterization and rejection for a positron camera

    International Nuclear Information System (INIS)

    Levin, C.S.; Tornai, M.P.; MacDonald, L.R.

    1996-01-01

    We have developed a miniature (1.2 cm 2 ) beta-ray camera prototype to assist a surgeon in locating and removing the margins of a resected tumor. When imaging positron emitting radiopharmaceuticals, annihilation gamma ray interactions in the detector can mimic those of the betas. The extent of the background contamination depends on the detector, geometry and tumor specificity of the radiopharmaceutical. We have characterized the effects that annihilation gamma rays have on positron imaging with the camera. We studied beta and gamma ray detection rates and imaging using small positron or electron sources directly exposed to the detector to simulate hot tumor remnants and a cylinder filled with 18 F to simulate annihilation background from the brain. For various ratios of phantom brain/tumor activity, a annihilation gamma rate of 1.8 cts/sec/gCi was measured in the CaF 2 (Eu) detector. We present two gamma-ray background rejection schemes that use a β-γ coincidence. Results show that the coincidence methods works with ∼99% gamma ray rejection efficiency

  19. A digital variable persistence oscilloscope for gamma cameras

    International Nuclear Information System (INIS)

    Fenwick, J.D.; Thompson, A.

    1981-01-01

    The system briefly described is intended as a direct replacement for the analogue persistence oscilloscope, particularly in systems without a computer processor. It uses digital and video techniques to produce an image quality suitable for use in positioning patients under the camera at a low cost (total cost of materials used, Pound500). The performance is superior to the analogue oscilloscope in that the image is displayed with 16 shades of grey. It incorporates an automatic brightness control which ensures that the image does not saturate at high count density, and the saturation can be changed manually allowing areas of low counts to be examined in the presence of high counts. The digital inability to store each single event as a dot which fades exponentially with time has been solved by adding each event into the appropriate cell of a digital display matrix, and then periodically dividing the contents of each image cell by two. The cells are addressed and divided in a pseudo-random pattern so that, to the observer, the whole image appears to fade smoothly and evenly. (U.K.)

  20. Study of cerebrovascular diseases and SPECT with 99mTc HMPAO

    International Nuclear Information System (INIS)

    Collazo de la Maza, A.; Borron Molinos, M.; Barroso, E.

    1997-01-01

    Thirty eight patients with Cerebrovascular disease, that had suffered a Thrombotic brain infraction, demonstrated by Computed electroencephalogram or Brain Mapping (BM) and Computerized Tomography (CT) were investigated with '99' '9' 'm' Tc HM-PAO brain SPECT. Their ages ranged from 37 to 73 years old, 18 males and 20 female. Some of them were followed up with these diagnostic methods. The acquisition and processing of the SPECT studies were donw with a SOPHY DS7 Gamma Camera. The results showed that the global diagnostic sensibility of the SPECT was 79%. The sensibility of SPECT in the Acute stage was 75 %, CT 57% and BM 92%. In Steady stage we found a high positivity of SPECT with 83 %, Ct 66% and BM 66%. In the Recuperation Stage SPECT was 77%, CT 66% and 45%. Some phenomenon like the Luxury Perfusion and Diaschisis were studied and it is possible to found some prognostic relation

  1. Analysis of dark current images of a CMOS camera during gamma irradiation

    Energy Technology Data Exchange (ETDEWEB)

    Náfrádi, Gábor, E-mail: nafradi@reak.bme.hu [INT, BME, EURATOM Association, H-1111 Budapest (Hungary); Czifrus, Szabolcs, E-mail: czifrus@reak.bme.hu [INT, BME, EURATOM Association, H-1111 Budapest (Hungary); Kocsis, Gábor, E-mail: kocsis.gabor@wigner.mta.hu [Wigner RCP, RMI, EURATOM Association, POB 49, 1525 Budapest (Hungary); Pór, Gábor, E-mail: por@reak.bme.hu [INT, BME, EURATOM Association, H-1111 Budapest (Hungary); Szepesi, Tamás, E-mail: szepesi.tamas@wigner.mta.hu [Wigner RCP, RMI, EURATOM Association, POB 49, 1525 Budapest (Hungary); Zoletnik, Sándor, E-mail: zoletnik.sandor@wigner.mta.hu [Wigner RCP, RMI, EURATOM Association, POB 49, 1525 Budapest (Hungary)

    2013-12-15

    Highlights: • Radiation tolerance of a fast framing CMOS camera EDICAM examined. • We estimate the expected gamma dose and spectrum of EDICAM with MCNP. • We irradiate EDICAM by 23.5 Gy in 70 min in a fission rector. • Dose rate normalised average brightness of frames grows linearly with the dose. • Dose normalised average brightness of frames follows the dose rate time evolution. -- Abstract: We report on the behaviour of the dark current images of the Event Detection Intelligent Camera (EDICAM) when placed into an irradiation field of gamma rays. EDICAM is an intelligent fast framing CMOS camera operating in the visible spectral range, which is designed for the video diagnostic system of the Wendelstein 7-X (W7-X) stellarator. Monte Carlo calculations were carried out in order to estimate the expected gamma spectrum and dose for an entire year of operation in W7-X. EDICAM was irradiated in a pure gamma field in the Training Reactor of BME with a dose of approximately 23.5 Gy in 1.16 h. During the irradiation, numerous frame series were taken with the camera with exposure times 20 μs, 50 μs, 100 μs, 1 ms, 10 ms, 100 ms. EDICAM withstood the irradiation, but suffered some dynamic range degradation. The behaviour of the dark current images during irradiation is described in detail. We found that the average brightness of dark current images depends on the total ionising dose that the camera is exposed to and the dose rate as well as on the applied exposure times.

  2. Use of gamma camera for measurement of the internal contamination with depleted uranium

    International Nuclear Information System (INIS)

    Spaic, R.; Markovic, S.; Pavlovic, S.; Pavlovic, R.; Ajdinovic, B.; Baskot, B.; Djurovic, B.

    2000-01-01

    Depleted uranium from radioactive wastes is used for manufacturing bullets used in Iraq, Republic of Serbia and Yugoslavia. These bullets are extremely dense and capable of penetrating heavily armored vehicles. Their medical importance lies in the fact that the bullets contain seventy percent depleted uranium which creates aerosolized particles less than five microns in diameter, small enough to be inhaled, after spontaneous bullet burn at impact. Nuclear medicine scientists must be aware of this and be prepared to measure internal contamination of persons exposed to this radioactive material. Whole body counters (WBC) represent appropriate equipment for this purpose but their availability in developing countries is not sufficient. Gamma camera is an alternative. The minimum detectable activity (MDA) of depleted uranium, iodine and technetium for gamma cameras was measured in this paper. Low energy X-ray 100 KeV with 20% windows are used for the depleted uranium detection. About 40% gamma emissions from depleted uranium fall within these limits. The activities measured (50-100 Bq) are about ten times higher then on WBC (5 Bq). This does not limit the use of gamma cameras for measurement of lung or whole body internal contamination with depleted uranium. (author)

  3. A didactic experiment showing the Compton scattering by means of a clinical gamma camera.

    Science.gov (United States)

    Amato, Ernesto; Auditore, Lucrezia; Campennì, Alfredo; Minutoli, Fabio; Cucinotta, Mariapaola; Sindoni, Alessandro; Baldari, Sergio

    2017-06-01

    We describe a didactic approach aimed to explain the effect of Compton scattering in nuclear medicine imaging, exploiting the comparison of a didactic experiment with a gamma camera with the outcomes from a Monte Carlo simulation of the same experimental apparatus. We employed a 99m Tc source emitting 140.5keV photons, collimated in the upper direction through two pinholes, shielded by 6mm of lead. An aluminium cylinder was placed on the source at 50mm of distance. The energy of the scattered photons was measured on the spectra acquired by the gamma camera. We observed that the gamma ray energy measured at each step of rotation gradually decreased from the characteristic energy of 140.5keV at 0° to 102.5keV at 120°. A comparison between the obtained data and the expected results from the Compton formula and from the Monte Carlo simulation revealed a full agreement within the experimental error (relative errors between -0.56% and 1.19%), given by the energy resolution of the gamma camera. Also the electron rest mass has been evaluated satisfactorily. The experiment was found useful in explaining nuclear medicine residents the phenomenology of the Compton scattering and its importance in the nuclear medicine imaging, and it can be profitably proposed during the training of medical physics residents as well. Copyright © 2017 Associazione Italiana di Fisica Medica. Published by Elsevier Ltd. All rights reserved.

  4. Design of a Compton camera for 3D prompt-{gamma} imaging during ion beam therapy

    Energy Technology Data Exchange (ETDEWEB)

    Roellinghoff, F., E-mail: roelling@ipnl.in2p3.fr [Universite de Lyon, F-69622 Lyon (France); Universite Lyon 1 and CNRS/IN2P3, UMR 5822, IPNL, F-69622 Villeurbanne (France); INSA-Lyon Laboratory of Nondestructive Testing using Ionizing Radiation (CNDRI), F-69621 Villeurbanne Cedex (France); Richard, M.-H., E-mail: mrichard@ipnl.in2p3.fr [Universite de Lyon, F-69622 Lyon (France); Universite Lyon 1 and CNRS/IN2P3, UMR 5822, IPNL, F-69622 Villeurbanne (France); INSA-Lyon Laboratory of Nondestructive Testing using Ionizing Radiation (CNDRI), F-69621 Villeurbanne Cedex (France); Chevallier, M.; Constanzo, J.; Dauvergne, D. [Universite de Lyon, F-69622 Lyon (France); Universite Lyon 1 and CNRS/IN2P3, UMR 5822, IPNL, F-69622 Villeurbanne (France); Freud, N. [INSA-Lyon Laboratory of Nondestructive Testing using Ionizing Radiation (CNDRI), F-69621 Villeurbanne Cedex (France); Henriquet, P.; Le Foulher, F. [Universite de Lyon, F-69622 Lyon (France); Universite Lyon 1 and CNRS/IN2P3, UMR 5822, IPNL, F-69622 Villeurbanne (France); Letang, J.M. [INSA-Lyon Laboratory of Nondestructive Testing using Ionizing Radiation (CNDRI), F-69621 Villeurbanne Cedex (France); Montarou, G. [LPC, CNRS/IN2P3, Clermont-F. University (France); Ray, C.; Testa, E.; Testa, M. [Universite de Lyon, F-69622 Lyon (France); Universite Lyon 1 and CNRS/IN2P3, UMR 5822, IPNL, F-69622 Villeurbanne (France); Walenta, A.H. [Uni-Siegen, FB Physik, Emmy-Noether Campus, D-57068 Siegen (Germany)

    2011-08-21

    We investigate, by means of Geant4 simulations, a real-time method to control the position of the Bragg peak during ion therapy, based on a Compton camera in combination with a beam tagging device (hodoscope) in order to detect the prompt gamma emitted during nuclear fragmentation. The proposed set-up consists of a stack of 2 mm thick silicon strip detectors and a LYSO absorber detector. The {gamma} emission points are reconstructed analytically by intersecting the ion trajectories given by the beam hodoscope and the Compton cones given by the camera. The camera response to a polychromatic point source in air is analyzed with regard to both spatial resolution and detection efficiency. Various geometrical configurations of the camera have been tested. In the proposed configuration, for a typical polychromatic photon point source, the spatial resolution of the camera is about 8.3 mm FWHM and the detection efficiency 2.5x10{sup -4} (reconstructable photons/emitted photons in 4{pi}). Finally, the clinical applicability of our system is considered and possible starting points for further developments of a prototype are discussed.

  5. Applications of iQID cameras

    Science.gov (United States)

    Han, Ling; Miller, Brian W.; Barrett, Harrison H.; Barber, H. Bradford; Furenlid, Lars R.

    2017-09-01

    iQID is an intensified quantum imaging detector developed in the Center for Gamma-Ray Imaging (CGRI). Originally called BazookaSPECT, iQID was designed for high-resolution gamma-ray imaging and preclinical gamma-ray single-photon emission computed tomography (SPECT). With the use of a columnar scintillator, an image intensifier and modern CCD/CMOS sensors, iQID cameras features outstanding intrinsic spatial resolution. In recent years, many advances have been achieved that greatly boost the performance of iQID, broadening its applications to cover nuclear and particle imaging for preclinical, clinical and homeland security settings. This paper presents an overview of the recent advances of iQID technology and its applications in preclinical and clinical scintigraphy, preclinical SPECT, particle imaging (alpha, neutron, beta, and fission fragment), and digital autoradiography.

  6. The Advanced Gamma-ray Imaging System (AGIS) - Camera Electronics Development

    Science.gov (United States)

    Tajima, Hiroyasu; Bechtol, K.; Buehler, R.; Buckley, J.; Byrum, K.; Drake, G.; Falcone, A.; Funk, S.; Hanna, D.; Horan, D.; Humensky, B.; Karlsson, N.; Kieda, D.; Konopelko, A.; Krawczynski, H.; Krennrich, F.; Mukherjee, R.; Ong, R.; Otte, N.; Quinn, J.; Schroedter, M.; Swordy, S.; Wagner, R.; Wakely, S.; Weinstein, A.; Williams, D.; Camera Working Group; AGIS Collaboration

    2010-03-01

    AGIS, a next-generation imaging atmospheric Cherenkov telescope (IACT) array, aims to achieve a sensitivity level of about one milliCrab for gamma-ray observations in the energy band of 50 GeV to 100 TeV. Achieving this level of performance will require on the order of 50 telescopes with perhaps as many as 1M total electronics channels. The larger scale of AGIS requires a very different approach from the currently operating IACTs, with lower-cost and lower-power electronics incorporated into camera modules designed for high reliability and easy maintenance. Here we present the concept and development status of the AGIS camera electronics.

  7. Emission computerized axial tomography from multiple gamma-camera views using frequency filtering.

    Science.gov (United States)

    Pelletier, J L; Milan, C; Touzery, C; Coitoux, P; Gailliard, P; Budinger, T F

    1980-01-01

    Emission computerized axial tomography is achievable in any nuclear medicine department from multiple gamma camera views. Data are collected by rotating the patient in front of the camera. A simple fast algorithm is implemented, known as the convolution technique: first the projection data are Fourier transformed and then an original filter designed for optimizing resolution and noise suppression is applied; finally the inverse transform of the latter operation is back-projected. This program, which can also take into account the attenuation for single photon events, was executed with good results on phantoms and patients. We think that it can be easily implemented for specific diagnostic problems.

  8. Gamma Camera with Image Amplifier: Application in Nuclear Medicine; Camera Gamma a Amplificateur d'Image: Application en Medecine Nucleaire

    Energy Technology Data Exchange (ETDEWEB)

    Kellershohn, C.; Vernejoul, P. de; Desgrez, A. [CEA, Service Hospitalier Frederic Joliot, Orsay (France); Lequais, J.; Roux, G.; Lansiart, A. [CEA, Centre d' Etudes Nucleaires de Saclay, Gif-Sur-Yvette (France)

    1969-05-15

    The camera described has an optical system consisting of a lead grid collimator with 649 cylindrical channels 130 mm long and 5.5 mm in diameter; a detector consisting of a mosaic of 700 NaI(Tl) crystals with an effective diameter of 5.5 mm, length 20 mm, and a distance of 7.5 mm between the axes; and a light amplification device consisting of an initial image amplifier (No. 9463 of the French Thomson-Houston Company), the photocathode of which is in optical contact with the detector and is itself optically coupled to a second, high-gain light amplifier (P 829A, from English Electric Valve). In accordance with a principle first laid down during the preceding Conference on Medical Isotope Scanning organized by the International Atomic Energy Agency, this second amplifier may also be used as an electronic shutter operated by a photomultiplier which selects the light originating in the radio active source under examination. This device very effectively suppresses the background from the first amplifier tube. With reference to applications, the camera is used for two types of operation: firstly for the activation of the electronic shutter device, the rate of whose opening and shutting may reach 10 kHz; the background is almost entirely eliminated and it is possible with trace doses of conventional radionuclides to obtain images of such organs as the thyroid, liver, kidney, etc., in very short exposure times by comparison with customary scanning; secondly, by utilizing radionuclides of very short half-life with very high activities (of the order of several mCi), it is no longer necessary to effect suppression of the background whose repetition frequency is limited to 10 kHz. One can thus obtain ultrashort exposure times, e.g., about 1/20th of a second for an amount of 10 mCi of {sup 99m}Tc; such exposure times make cinematography possible. Various examples are supplied of applications making use of {sup 99m}Tc, {sup 137m}Ba and {sup 133}Xe in the field of vascular and

  9. Localization of functioning parathyroid adenomas by SPECT/CT. Report of two cases

    International Nuclear Information System (INIS)

    Pruzzo C, Rossana; Amaral P, Horacio; Rossi F, Ricardo; Morales K, Barbara; Martinez G, M.Eugenia

    2013-01-01

    Single photon emission computed tomography and computed tomography (SPECT/CT), integrates a gamma camera and a CT scan and is effective for the location of parathyroid adenomas. We report a 55 years old male and a 80 years old female with primary hyperparathyroidism. In both cases the 99m Tc-Sestamibi parathyroid scintigraphy detected a functioning nodule whose presence was confirmed with SPECT/CT

  10. Multiwire proportional gamma camera for imaging /sup 99/Tcsup(m) radionuclide distributions

    Energy Technology Data Exchange (ETDEWEB)

    Bateman, J E; Connolly, J F [Science Research Council, Chilton (UK). Rutherford Lab.

    1978-05-01

    A gamma camera made of multiple multiwire proportional chambers with thin converter foils has been evaluated for clinical application. Results are presented from a small prototype (10 cm x 10 cm) showing good imaging of /sup 99/Tcsup(m) radionuclide distributions and confirming the predictions of the theory regarding quantum efficiency and spatial resolution. The technique is especially aimed at creating a gamma camera with an active area > approximately 3 1m/sup 2/, a quantum efficiency of 15% and a spatial resolution approximately 3 mm, whole body scanning and tomographic applications. The results generated by the current prototype indicate that the above requirements can be met using relatively cheap mass production techniques from the electronics industry. This apparatus is covered by patent application number 26595/77.

  11. A multiwire proportional gamma camera for imaging 99Tcsup(m) radionuclide distributions

    International Nuclear Information System (INIS)

    Bateman, J.E.; Connolly, J.F.

    1978-01-01

    A gamma camera made of multiple multiwire proportional chambers with thin converter foils has been evaluated for clinical application. Results are presented from a small prototype (10 cm x 10 cm) showing good imaging of 99 Tcsup(m) radionuclide distributions and confirming the predictions of the theory regarding quantum efficiency and spatial resolution. The technique is especially aimed at creating a gamma camera with an active area > approximately 3 1m 2 , a quantum efficiency of 15% and a spatial resolution approximately 3 mm, whole body scanning and tomographic applications. The results generated by the current prototype indicate that the above requirements can be met using relatively cheap mass production techniques from the electronics industry. This apparatus is covered by patent application number 26595/77. (author)

  12. A gamma camera method for quantitation of split renal function in children followed for vesicoureteric reflux

    International Nuclear Information System (INIS)

    Tamminen, T.E.; Riihimaeki, E.J.; Taehti, E.E.; Helsinki Univ. Central Hospital

    1978-01-01

    A method for quantitative estimation of split renal function using a computerized gamma camera system is described. 42 children and adolescents with existing or preexisting vesicouretric reflux and recurrent urinary tract infection were investigated. Total renal clearance of DTPA was calculated with a disapperarance curve derived from the largest extrarenal area in the field of view of a gamma camera with diverging collimator. Split renal function was estimated with the slopes of second phase renograms. The plasma disaapearance clearance of DTPA, calculated using one compartement model with two late blood samples, gave similar resusults with the clearance estimated from the body disappearance curves. The proportional planimetric renal parenchymal areas had good correlation with the split clearance estimated from renogram slopes. The method offers data on renal function and urinary tract dynamics which is very valuable in the follow-up of children with recurrent urinary tract infection and vesicoureteric reflux. (orig.) [de

  13. Development of gamma camera display phantom for quality control in developing countries

    International Nuclear Information System (INIS)

    Todd-Pokropek, A.

    1981-08-01

    A special phantom suitable for the routine evaluation of ''end-to-end'' gamma camera system performance, that is, system performance from input to output, is described. The design finally adopted, called the ''strip-wedge phantom'' and consisting of an array of copper or aluminium wedges of various thicknesses, permits the evaluation of contrast along one axis and resolution along the other. It is proposed that on acceptance testing of a gamma camera system a series of progressively degraded images should be obtained from the best possible with the system to very poor. An ''action threshold'' should then be defined such that image quality below this threshold would warrant such action as calling in the service engineer. Daily routine images should then be examined with reference to this threshold. Experience with the phantom is summarized

  14. Technical approach to improvement of SPECT images

    International Nuclear Information System (INIS)

    Fukukita, Hiroyoshi

    1985-01-01

    At present, a large number of SPECT systems are being widely used in Japan, hence, it is reasonable for us to know the physical and imaging characteristics of these SPECT devices, and also to recommend the optimum utility of SPECT systems. For this reason, a survey respect of characteristics of the commercialy available SPECT devices was carried out. In addition to this, various factors which have significant influence over SPECT image quality, such as, data acquisition matrix, reconstruction filter, γ-ray attenuation correction and daily quality control procedure, were also investigated. The materials used for this study are PET/SPECT phantom, Alderson liver phantom filled with Tc-99m solution, and either LFOV-E or ZLC-7500 interfaced to Scintipac 2400 minicomputer with 256 K byte of memory. Following are the results of this study. 1) The suitable data acquisition procedure was 128 x 128 matrix for linear sampling and approximately 64 views for angular sampling. 2) Reconstructed image using pre-processing filter with Wiener and Butterworth filters provided high quality image as compared with the Ramp filter. 3) Weighted backprojection method (WBP) proposed by Tanaka was superior to other methods, such as Sorenson method and Chang method in the object with non-uniform distribution of radionuclide. 4) It was found that uniformity correction of gamma camera and precise adjustment of the center of rotation are most important to maintain the images with a high quality. (author)

  15. From whole-body counting to imaging: The computer aided collimation gamma camera project (CACAO)

    Energy Technology Data Exchange (ETDEWEB)

    Jeanguillaume, C.; Begot, S.; Quartuccio, M.; Douiri, A.; Ballongue, P

    2000-07-01

    Whole-body counting is the method of choice for in vivo detection of contamination. To extend this well established method, the possible advantages of imaging radiocontaminants are examined. The use of the CACAO project is then studied. A comparison of simulated reconstructed images obtained by the CACAO project and by a conventional gamma camera used in nuclear medicine follows. Imaging a radionuclide contaminant with a geometrical sensitivity of 10{sup -2} seems possible in the near future. (author)

  16. From whole-body counting to imaging: The computer aided collimation gamma camera project (CACAO)

    International Nuclear Information System (INIS)

    Jeanguillaume, C.; Begot, S.; Quartuccio, M.; Douiri, A.; Ballongue, P.

    2000-01-01

    Whole-body counting is the method of choice for in vivo detection of contamination. To extend this well established method, the possible advantages of imaging radiocontaminants are examined. The use of the CACAO project is then studied. A comparison of simulated reconstructed images obtained by the CACAO project and by a conventional gamma camera used in nuclear medicine follows. Imaging a radionuclide contaminant with a geometrical sensitivity of 10 -2 seems possible in the near future. (author)

  17. An innovative silicon photomultiplier digitizing camera for gamma-ray astronomy

    Czech Academy of Sciences Publication Activity Database

    Heller, M.; Schioppa, E.jr.; Porcelli, A.; Pujadas, I.T.; Zietara, K.; della Volpe, D.; Montaruli, T.; Cadoux, F.; Favre, Y.; Aguilar, J.A.; Christov, A.; Prandini, E.; Rajda, P.; Rameez, M.; Bilnik, W.; Blocki, J.; Bogacz, L.; Borkowski, J.; Bulik, T.; Frankowski, A.; Grudzinska, M.; Idzkowski, B.; Jamrozy, M.; Janiak, M.; Kasperek, J.; Lalik, K.; Lyard, E.; Mach, E.; Mandát, Dušan; Marszalek, A.; Medina Miranda, L. D.; Michałowski, J.; Moderski, R.; Neronov, A.; Niemiec, J.; Ostrowski, M.; Pasko, P.; Pech, Miroslav; Schovánek, Petr; Seweryn, K.; Sliusar, V.; Skowron, K.; Stawarz, L.; Stodulska, M.; Stodulski, M.; Walter, R.; Wiecek, M.; Zagdanski, A.

    2017-01-01

    Roč. 77, č. 1 (2017), s. 1-31, č. článku 47. ISSN 1434-6044 R&D Projects: GA MŠk LE13012; GA MŠk LG14019 Institutional support: RVO:68378271 Keywords : silicon photomultiplier * digitizing camera * gamma-ray astronomy Subject RIV: BF - Elementary Particles and High Energy Physics OBOR OECD: Particles and field physics Impact factor: 5.331, year: 2016

  18. An alternate way for image documentation in gamma camera processing units

    International Nuclear Information System (INIS)

    Schneider, P.

    1980-01-01

    For documentation of images and curves generated by a gamma camera processing system a film exposure tool from a CT system was linked to the video monitor by use of a resistance bridge. The machine has a stock capacity of 100 plane films. For advantage there is no need for an interface, the complete information on the monitor is transferred to the plane film and compared to software controlled data output on printer or plotter the device is tremendously time saving. (orig.) [de

  19. SPECT I-123 iodoamphetamine brain imaging

    International Nuclear Information System (INIS)

    Tikofsky, R.S.; Liebman, A.; Hellman, R.S.; Collier, B.D.; Voslar, A.M.

    1988-01-01

    SPECT/IMP studies of 100 patients with a presumptive diagnosis of dementia were performed with a rotating gamma camera 15-20 minutes after intravenous injection of 3.5 mCi of IMP. Of these studies, 43 were interpreted as normal for age; 28 demonstrated decreased but not absent activity bilaterally in posterior parietal/occipital regions (consistent with Alzheimer-type dementia); 28 showed unilateral abnormalities in regional cerebral blood flow consistent with cerebrovascular disease; and one had mixed findings. Based on SPECT/IMP results, further diagnostic testing and/or management would be altered for 72% of patients, suggesting that SPECT/IMP provides valuable data, not available on clinical examination, to guide the evaluation and management of demented patients

  20. The role of the gamma camera in the study of gastric function

    International Nuclear Information System (INIS)

    Esser, J.D.; Mannell, A.; Hinder, R.A.

    1984-01-01

    With the gamma camera food labelled with radioactive tracers can be visualized as it enters and leaves the stomach. Radiopharmaceuticals such as technetium-99m di-isopropyl iminodiacetic acid simulate the bile pathway and can be used to demonstrate duodenogastric reflux. Duodenogastric reflux and gastric emptying of solid or liquid meals can be quantitated when the gamma camera is linked to a microprocessor. The test meal used at the Johannesburg and Hillbrow Hospitals consists of a 99 (sup m)Tc-labelled chicken liver weighing 30 g mixed with 70 g cooked ground beef. These studies are valuable for investigating symptomatic postgastrectomy patients and patients who have neurogenic or metabolic diseases which result in abnormal gastric function. The efficacy of drugs given to relieve these symptoms can also be assessed. In this paper we discuss the nuclear medicine techniques used to study gastric function. Examples are given of abnormalities which may not be diagnosed on gastroscopy or barium meal examination but which can be clearly identified by gamma camera techniques

  1. Feasibility study of a lens-coupled charge-coupled device gamma camera

    International Nuclear Information System (INIS)

    Lee, Hakjae; Jung, Youngjun; Kim, Jungmin; Bae, Seungbin; Lee, Kisung; Kang, Jungwon

    2011-01-01

    A charge-coupled device (CCD) is generally used in a digital camera as a light-collecting device such as a photomultiplier tube (PMT). Because of its low sensitivity and very high dark current, CCD have not been popularly used for gamma imaging systems. However, a recent CCD technological breakthrough has improved CCD sensitivity, and the use of a Peltier cooling system can significantly minimize the dark current. In this study, we investigated the feasibility of a prototype CCD gamma camera consisting of a CsI scintillator, optical lenses, and a CCD module. Despite electron-multiplying (EM) CCDs having higher performance, in this study, we built a cost-effective system consisted of low-cost components compared to EMCCDs. Our prototype detector consists of a CsI scintillator, two optical lenses, and a conventional Peltier-cooled CCD. The performance of this detector was evaluated by acquiring the sensitivity, resolution, and the modulation transfer function (MTF). The sensitivity of the prototype detector showed excellent linearity. With a 1 mm-diameter pinhole collimator, the full width at half-maximum (FWHM) of a 1.1 mm Tc-99m line source image was 2.85 mm. These results show that the developed prototype camera is feasible for small animal gamma imaging.

  2. An operative gamma camera for sentinel lymph node procedure in case of breast cancer

    CERN Document Server

    Salvador, S; Mathelin, C; Guyonne, J; Huss, D

    2007-01-01

    Large field of view gamma cameras are widely used to perform lymphoscintigraphy in the sentinel lymph nodes (SLN) procedure in case of breast cancer. However, they are not specified for this application and their sizes do not enable their use in the operative room to control the excision of the all SLN. We present the results obtained with a prototype of a new mini gamma camera developed especially for the operative lymphoscintigraphy of the axillary area in case of breast cancer. This prototype is composed of 10 mm thick parallel lead collimator, a 2 mm thick GSO:Ce inorganic scintillating crystal from Hitachi and a Hamamatsu H8500 flat panel multianode (64 channels) photomultiplier tube (MAPMT) equipped with a dedicated electronics. Its actual field of view is 50 × 50mm2. The gamma interaction position in the GSO scintillating plate is obtained by calculating the center of gravity of the fired MAPMT channels. The measurements performed with this prototype demonstrate the usefulness of this mini gamma camer...

  3. Experience with dedicated ultra fast solid state cardiac gamma camera: technologist perspective

    International Nuclear Information System (INIS)

    Parab, Anil; Gaikar, Anil; Patil, Kashinath; Lele, V.

    2010-01-01

    Full text: To describe technologist perspective of working with ultra fast solid state gamma camera and comparison with conventional dual head gamma camera. Material and Methods: 900 Myocardial Perfusion scan were carried out on dedicated solid state detector cardiac camera between 1st February 2010 till 29th August 2010. 27 studies were done back to back on a conventional dual head gamma camera. In 2 cases dual head isotope imaging was done (Thallium+ 99m Tc-tetrofosmin). Rest stress protocol was used in 600 patients and stress - rest protocol was used in 300. 1:3 ratio of injected activity was maintained for both protocols (5 mCi for 1st study and 15 mCi for second study). For Rest - Stress protocol, 5 mCi of 99m Tc - Tetrofosmin was injected at rest, 40 minutes later, 5 min image was acquired on the solid state detector. Patient was then stressed. 15 mCi 99m Tc - Tetrofosmin was injected at peak stress. Images were acquired 20 minutes later for 3 minutes (total duration of study 90-100 min). For stress rest protocol, 5 mCi 99m Tc - Tetrofosmin was injected at peak stress. 5 mCi images were acquired 20 minutes later. Rest injection of 15 mCi was given 1 hour post stress injection. Rest images were acquired 40 minutes after rest injection (total duration of study 110-120 min). Results: We observed even with lesser amount activity and acquisition time of 5 min/cardiac scan it showed high sensitivity count rate over 2.2-4.7 kcps (10 times more counts than standard gamma camera). System gives better energy resolution < 7%. Better image contrast. Dual isotope imaging can be possible. Spatial resolution 4.3-4.9 mm. Excellent quality images were obtained using low activities (5 mCi/15 mCi) using 1/3rd the acquisition time compared to conventional dual head gamma camera Even in obese patients 7 mCi/21 mCi activity yielded excellent images at 1/3 rd acquisition time Quick acquisition resulted in greater patient comfort and no motion artifact also due to non rotation of

  4. Brain lesion analysis using three-dimensional SPECT imaging

    International Nuclear Information System (INIS)

    Shibata, Iekado; Onagi, Atsuo; Kuroki, Takao

    1995-01-01

    A three-headed gamma camera (PRISM 3000) is capable to scan the protocol of early dynamic SPECT and to analyze two radioisotopes at the same time. We have framed three-dimensional brain SPECT images for several brain diseases by using the Application Visualization System (AVS). We carried out volume measurements in brain tumors and/or AVMs by applying this methodology. Thallium-201 and/or 123I-IMP were used for brain SPECT imaging. The dynamic scan protocol was changed in accordance with the given disease. The protocol for brain tumors was derived from a preliminary comparative study with thallium-201 and 123I-IMP that had suggested a disparity in the detection of brain tumors and the differentiation between tumor tissue and normal brain. The three-dimension SPECT image represented the brain tumor or AVM in a striking fashion, and the changes with respect to tumor or AVM after radiosurgery or embolization were understood readily. (author)

  5. Development of a tomographic system adapted to 3D measurement of contaminated wounds based on the Cacao concept (Computer aided collimation Gamma Camera)

    International Nuclear Information System (INIS)

    Douiri, A.

    2002-03-01

    The computer aided collimation gamma camera (CACAO in French) is a gamma camera using a collimator with large holes, a supplementary linear scanning motion during the acquisition and a dedicated reconstruction program taking full account of the source depth. The CACAO system was introduced to improve both the sensitivity and the resolution in nuclear medicine. This thesis focuses on the design of a fast and robust reconstruction algorithm in the CACAO project. We start by an overview of tomographic imaging techniques in nuclear medicine. After modelling the physical CACAO system, we present the complete reconstruction program which involves three steps: 1) shift and sum 2) deconvolution and filtering 3) rotation and sum. The deconvolution is the critical step that decreases the signal to noise ratio of the reconstructed images. We propose a regularized multi-channel algorithm to solve the deconvolution problem. We also present a fast algorithm based on Splines functions and preserving the high quality of the reconstructed images for the shift and the rotation steps. Comparisons of simulated reconstructed images in 2D and 3D for the conventional system (CPHC) and CACAO demonstrate the ability of CACAO system to increase the quality of the SPECT images. Finally, this study concludes with an experimental approach with a pixellated detector conceived for a 3D measurement of contaminated wounds. This experimentation proves the possible advantages of coupling the CACAO project with pixellated detectors. Moreover, a variety of applications could fully benefit from the CACAO system, such as low activity imaging, the use of high-energy gamma isotopes and the visualization of deep organs. Moreover the combination of the CACAO system with a pixels detector may open up further possibilities for the future of nuclear medicine. (author)

  6. Detection of mixed-range proton pencil beams with a prompt gamma slit camera

    International Nuclear Information System (INIS)

    Priegnitz, M; Helmbrecht, S; Fiedler, F; Janssens, G; Smeets, J; Vander Stappen, F; Perali, I; Sterpin, E

    2016-01-01

    With increasing availability of proton and particle therapy centers for tumor treatment, the need for in vivo range verification methods comes more into the focus. Imaging of prompt gamma rays emitted during the treatment is one of the possibilities currently under investigation. A knife-edge shaped slit camera was recently proposed for this task and measurements proved the feasibility of range deviation detection in homogeneous and inhomogeneous targets. In the present paper, we concentrate on laterally inhomogeneous materials, which lead to range mixing situations when crossed by one pencil beam: different sections of the beam have different ranges. We chose exemplative cases from clinical irradiation and assembled idealized tissue equivalent targets. One-dimensional emission profiles were obtained by measuring the prompt gamma emission with the slit camera. It could be shown that the resulting range deviations can be detected by evaluation of the measured data with a previously developed range deviation detection algorithm. The retrieved value, however, strongly depends on the target composition, and is not necessarily in direct relation to the ranges of both parts of the beam. By combining the range deviation detection with an analysis of the slope of the distal edge of the measured prompt gamma profile, the origin of the detected range deviation, i.e. the mixed range of the beam, is also identified. It could be demonstrated that range mixed prompt gamma profiles exhibit less steep distal slopes than profiles from beams traversing laterally homogeneous material. For future application of the slit camera to patient irradiation with double scattered proton beams, situations similar to the range mixing cases are present and results could possibly apply. (paper)

  7. CBF tomographic measurement with the scintillation camera

    International Nuclear Information System (INIS)

    Kayayan, R.; Philippon, B.; Pehlivanian, E.

    1989-01-01

    Single photon emission tomography (SPECT) allows calculation of regional cerebral blood flow (CBF) in multiple cross-sections of the human brain. The methods of Kanno and Lassen is utilized and a study of reproductibility in terms of integration numbers and period of integrations is performed by computer simulation and experimental study with a Gamma-camera. Finally, the possibility of calculating the regional cerabral blood flow with a double headed rotating Gamma-camera by inert gas inhalation, like the Xenon-133 is discussed [fr

  8. Realization and study of spectral properties of the ISGRI gamma-ray camera; Mise en oeuvre et etude des proprietes spectrales de la gamma-camera ISGRI

    Energy Technology Data Exchange (ETDEWEB)

    Limousin, O

    2001-11-01

    This work evaluates spectroscopic and physical properties of CdTe detectors in view of assembling a large number on a new generation spectro-imager for space gamma-ray astronomy. Study, optimization, realization and calibration of modular detection units of the ISGRI camera are described. After a description of the experimental context of the INTEGRAL program and a review of the physical processes involved in gamma-ray photon detectors, we present an analysis of the properties of CdTe detectors attempting to be so exhaustive as possible. We propose the base point of a global model, which relates charge transport properties, spectral response and possible instabilities in the detectors. We propose a new formulation of the Hecht relation that describes charge loss as a function of the detector charge transport properties. We discuss at length the method of charge loss correction and its consequences on the associated integrated electronics definition. Finally, we illustrate our instrument capabilities using as an example the observation of titanium 44 lines in historical supernovae. (author)

  9. Development of an LYSO based gamma camera for positron and scinti-mammography

    Science.gov (United States)

    Liang, H.-C.; Jan, M.-L.; Lin, W.-C.; Yu, S.-F.; Su, J.-L.; Shen, L.-H.

    2009-08-01

    In this research, characteristics of combination of PSPMTs (position sensitive photo-multiplier tube) to form a larger detection area is studied. A home-made linear divider circuit was built for merging signals and readout. Borosilicate glasses were chosen for the scintillation light sharing in the crossover region. Deterioration effect caused by the light guide was understood. The influences of light guide and crossover region on the separable crystal size were evaluated. According to the test results, a gamma camera with a crystal block of 90 × 90 mm2 covered area, composed of 2 mm LYSO crystal pixels, was designed and fabricated. Measured performances showed that this camera worked fine in both 511 keV and lower energy gammas. The light loss behaviour within the crossover region was analyzed and realized. Through count rate measurements, the 176Lu nature background didn't show severe influence on the single photon imaging and exhibited an amount of less than 1/3 of all the events acquired. These results show that with using light sharing techniques, combination of multiple PSPMTs in both X and Y directions to build a large area imaging detector is capable to be achieved. Also this camera design is feasible to keep both the abilities for positron and single photon breast imaging applications. Separable crystal size is 2 mm with 2 mm thick glass applied for the light sharing in current status.

  10. Development of an LYSO based gamma camera for positron and scinti-mammography

    International Nuclear Information System (INIS)

    Liang, H-C; Jan, M-L; Lin, W-C; Yu, S-F; Shen, L-H; Su, J-L

    2009-01-01

    In this research, characteristics of combination of PSPMTs (position sensitive photo-multiplier tube) to form a larger detection area is studied. A home-made linear divider circuit was built for merging signals and readout. Borosilicate glasses were chosen for the scintillation light sharing in the crossover region. Deterioration effect caused by the light guide was understood. The influences of light guide and crossover region on the separable crystal size were evaluated. According to the test results, a gamma camera with a crystal block of 90 x 90 mm 2 covered area, composed of 2 mm LYSO crystal pixels, was designed and fabricated. Measured performances showed that this camera worked fine in both 511 keV and lower energy gammas. The light loss behaviour within the crossover region was analyzed and realized. Through count rate measurements, the 176 Lu nature background didn't show severe influence on the single photon imaging and exhibited an amount of less than 1/3 of all the events acquired. These results show that with using light sharing techniques, combination of multiple PSPMTs in both X and Y directions to build a large area imaging detector is capable to be achieved. Also this camera design is feasible to keep both the abilities for positron and single photon breast imaging applications. Separable crystal size is 2 mm with 2 mm thick glass applied for the light sharing in current status.

  11. Performances evaluation of the coincidence detection on a gamma-camera

    International Nuclear Information System (INIS)

    Dreuille, O. de; Gaillard, J.F.; Brasse, D.; Bendriem, B.; Groiselle, C.; Rocchisani, J.M.; Moretti, J.L.

    2000-01-01

    The performance of the VERTEX gamma-camera (ADAC) working in coincidence mode are investigated using a protocol derived from the NEMA and IEC recommendations. With a field of view determined by two rectangular detectors (50.8 cm x 40 cm) composed of NaI crystal, this camera allows a 3-D acquisition with different energy window configurations: photopeak-photopeak only (PP) and photopeak-photopeak + photopeak-Compton (PC). An energy resolution of 11% and a scatter fraction of 27% and 33% for the 3D-PP and 3D-PC mode respectively are the main significant results of our study. The spatial resolution equals 5.9 mm and the limit of the detectability ranges from 16 mm to 13 mm for a contrast of 2.5: as a function of the random estimation, the maximum of the Noise Equivalent Count rate varies from 3 kcps to 4.5 kcps for the PP mode and from 3.85 kcps to 6.1 kcps for the PC mode. These maxima are reached for a concentration of 8 kBq/ml for the PP mode and 5 kBq/ml for the PC mode. These values are compared with the results obtained by other groups for the VERTEX gamma camera and several dedicated PET systems. (authors)

  12. A micro-machined retro-reflector for improving light yield in ultra-high-resolution gamma cameras

    NARCIS (Netherlands)

    Heemskerk, J.W.T.; Korevaar, M.A.N.; Kreuger, R.; Ligtvoet, C.M.; Schotanus, P.; Beekman, F.J.

    2009-01-01

    High-resolution imaging of x-ray and gamma-ray distributions can be achieved with cameras that use charge coupled devices (CCDs) for detecting scintillation light flashes. The energy and interaction position of individual gamma photons can be determined by rapid processing of CCD images of

  13. A pixellated gamma-camera based on CdTe detectors clinical interests and performances

    CERN Document Server

    Chambron, J; Eclancher, B; Scheiber, C; Siffert, P; Hage-Ali, M; Regal, R; Kazandjian, A; Prat, V; Thomas, S; Warren, S; Matz, R; Jahnke, A; Karman, M; Pszota, A; Németh, L

    2000-01-01

    A mobile gamma camera dedicated to nuclear cardiology, based on a 15 cmx15 cm detection matrix of 2304 CdTe detector elements, 2.83 mmx2.83 mmx2 mm, has been developed with a European Community support to academic and industrial research centres. The intrinsic properties of the semiconductor crystals - low-ionisation energy, high-energy resolution, high attenuation coefficient - are potentially attractive to improve the gamma-camera performances. But their use as gamma detectors for medical imaging at high resolution requires production of high-grade materials and large quantities of sophisticated read-out electronics. The decision was taken to use CdTe rather than CdZnTe, because the manufacturer (Eurorad, France) has a large experience for producing high-grade materials, with a good homogeneity and stability and whose transport properties, characterised by the mobility-lifetime product, are at least 5 times greater than that of CdZnTe. The detector matrix is divided in 9 square units, each unit is composed ...

  14. Anything wrong with brain SPECT? Not really

    International Nuclear Information System (INIS)

    Pavel, D.G.; Davis, G.; Craita, I.; Liu, P.

    2002-01-01

    Aim: Despite increased evidence about the usefulness of Brain SPECT in Neuro-Psychiatry, it continues to represent only a low percentage of Nuclear Medicine procedures. The prevalent perception is that it is an inadequate diagnostic tool, and/or is not changing patient management. There are objective reasons for this, as the lack of awareness by Psychiatrists about the value of SPECT, but most important is the frequently poor quality of images provided. This can be due to inadequate gamma cameras but is mostly due to poor quality software. Materials and Methods: High resolution brain SPECT via triple head gamma camera, super-high resolution fan beam collimator and Tc-HMPAO. A combination of commercial software and local optimization was used for the final displays as well as for realignment of sequential brain SPECT studies. Results: We found out that 6 basic software improvements are needed to generate a final display where features can be clearly distinguished and which can be also easily assimilated by the referring physician. 1) Color scales: simple and efficient tools needed to generate user friendly and semiquantitative color shades as needed. Unfortunately various color scales may be needed depending on printer and paper used. 2): 3 D displays allowing, multiple standardized thresholdings, any number of groupings, differential coloring (with functional meaning) and adequate labeling. Should be completely or at least mostly automatic. 3) Automatic realignment of sequential studies: such programs exist in various forms (free WWW versions, proprietary Beta versions, etc.) but are still not supplied by the gamma camera vendors for general use. Should provide SPECT -SPECT and SPECT MRI options. 4) Localization of structures and slices a) Triangulation of structures and b) Identification of section location. 5) Graphics improvement for generating any number of optimized summary displays to accompany reports. 6) Availability of voxel based quantification software

  15. On-Line High Dose-Rate Gamma Ray Irradiation Test of the CCD/CMOS Cameras

    Energy Technology Data Exchange (ETDEWEB)

    Cho, Jai Wan; Jeong, Kyung Min [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2012-05-15

    In this paper, test results of gamma ray irradiation to CCD/CMOS cameras are described. From the CAMS (containment atmospheric monitoring system) data of Fukushima Dai-ichi nuclear power plant station, we found out that the gamma ray dose-rate when the hydrogen explosion occurred in nuclear reactors 1{approx}3 is about 160 Gy/h. If assumed that the emergency response robot for the management of severe accident of the nuclear power plant has been sent into the reactor area to grasp the inside situation of reactor building and to take precautionary measures against releasing radioactive materials, the CCD/CMOS cameras, which are loaded with the robot, serve as eye of the emergency response robot. In the case of the Japanese Quince robot system, which was sent to carry out investigating the unit 2 reactor building refueling floor situation, 7 CCD/CMOS cameras are used. 2 CCD cameras of Quince robot are used for the forward and backward monitoring of the surroundings during navigation. And 2 CCD (or CMOS) cameras are used for monitoring the status of front-end and back-end motion mechanics such as flippers and crawlers. A CCD camera with wide field of view optics is used for monitoring the status of the communication (VDSL) cable reel. And another 2 CCD cameras are assigned for reading the indication value of the radiation dosimeter and the instrument. In the preceding assumptions, a major problem which arises when dealing with CCD/CMOS cameras in the severe accident situations of the nuclear power plant is the presence of high dose-rate gamma irradiation fields. In the case of the DBA (design basis accident) situations of the nuclear power plant, in order to use a CCD/CMOS camera as an ad-hoc monitoring unit in the vicinity of high radioactivity structures and components of the nuclear reactor area, a robust survivability of this camera in such intense gamma-radiation fields therefore should be verified. The CCD/CMOS cameras of various types were gamma irradiated at a

  16. Design study of a Compton camera for prompts-gamma imaging during ion beam therapy

    International Nuclear Information System (INIS)

    Richard, Marie-Helene

    2012-01-01

    Ion beam therapy is an innovative radiotherapy technique using mainly carbon ion and proton irradiations. Its aim is to improve the current treatment modalities. Because of the sharpness of the dose distributions, a control of the dose if possible in real time is highly desirable. A possibility is to detect the prompt gamma rays emitted subsequently to the nuclear fragmentations occurring during the treatment of the patient. In a first time two different Compton cameras (double and single scattering) have been optimised by means of Monte Carlo simulations. The response of the camera to a photon point source with a realistic energy spectrum was studied. Then, the response of the camera to the irradiation of a water phantom by a proton beam was simulated. It was first compared with measurement performed with small-size detectors. Then, using the previous measurements, we evaluated the counting rates expected in clinical conditions. In the current set-up of the camera, these counting rates are pretty high. Pile up and random coincidences will be problematic. Finally we demonstrate that the detection system is capable to detect a longitudinal shift in the Bragg peak of ± 5 mm, even with the current reconstruction algorithm. (author)

  17. A new collimator for measurement of rCBF by means of gamma camera

    International Nuclear Information System (INIS)

    Zechmann, W.; Oberladstaetter, M.; Raccabona, G.; Vogl, G.; Gerstenbrand, F.

    1982-01-01

    Atraumatic measurement of rCBF by means of gamma camera and conventional collimators requires high doses of 133 Xenon to obtain high count rates over the cerebral ROI's. The input of time-activity curve of breathing air by means of a probe measurement is not possible on line without difficulties. A new collimator, developed by ours, which is comparable with standard rCBF-Multiprobe systems, which allows high countrates and low dose of 133 Xenon is presented. A special air bypass enables to get the breathing curve with simple ROI technique. The collimator can easily be adapted to the camera by means of an insert adapter ring. With this collimator the rCBF measurement with conventional equipment of a nuclear medicine department is possible. (Author)

  18. TU-H-206-01: An Automated Approach for Identifying Geometric Distortions in Gamma Cameras

    Energy Technology Data Exchange (ETDEWEB)

    Mann, S; Nelson, J [Clinical Imaging Physics Group and Carl E. Ravin Advanced Imaging Laboratories, Department of Radiology, Duke University Medical Center, Durham, North Carolina 27705 and Medical Physics Graduate Program, Duke University, Durham, North Carolina 27705 (United States); Samei, E [Clinical Imaging Physics Group and Carl E. Ravin Advanced Imaging Laboratories, Department of Radiology, Duke University Medical Center, Durham, North Carolina 27705 and Departments of Physics, Electrical and Computer Engineering, and Biomedical Engineering, and Medical Physics Graduate Program, Duke University, Durham, North Carolina 27705 (United States)

    2016-06-15

    Purpose: To develop a clinically-deployable, automated process for detecting artifacts in routine nuclear medicine (NM) quality assurance (QA) bar phantom images. Methods: An artifact detection algorithm was created to analyze bar phantom images as part of an ongoing QA program. A low noise, high resolution reference image was acquired from an x-ray of the bar phantom with a Philips Digital Diagnost system utilizing image stitching. NM bar images, acquired for 5 million counts over a 512×512 matrix, were registered to the template image by maximizing mutual information (MI). The MI index was used as an initial test for artifacts; low values indicate an overall presence of distortions regardless of their spatial location. Images with low MI scores were further analyzed for bar linearity, periodicity, alignment, and compression to locate differences with respect to the template. Findings from each test were spatially correlated and locations failing multiple tests were flagged as potential artifacts requiring additional visual analysis. The algorithm was initially deployed for GE Discovery 670 and Infinia Hawkeye gamma cameras. Results: The algorithm successfully identified clinically relevant artifacts from both systems previously unnoticed by technologists performing the QA. Average MI indices for artifact-free images are 0.55. Images with MI indices < 0.50 have shown 100% sensitivity and specificity for artifact detection when compared with a thorough visual analysis. Correlation of geometric tests confirms the ability to spatially locate the most likely image regions containing an artifact regardless of initial phantom orientation. Conclusion: The algorithm shows the potential to detect gamma camera artifacts that may be missed by routine technologist inspections. Detection and subsequent correction of artifacts ensures maximum image quality and may help to identify failing hardware before it impacts clinical workflow. Going forward, the algorithm is being

  19. Use of calibration methodology of gamma cameras for the workers surveillance using a thyroid simulator

    International Nuclear Information System (INIS)

    Alfaro, M.; Molina, G.; Vazquez, R.; Garcia, O.

    2010-09-01

    In Mexico there are a significant number of nuclear medicine centers in operation. For what the accidents risk related to the transport and manipulation of open sources used in nuclear medicine can exist. The National Institute of Nuclear Research (ININ) has as objective to establish a simple and feasible methodology for the workers surveillance related with the field of the nuclear medicine. This radiological surveillance can also be applied to the public in the event of a radiological accident. To achieve this it intends to use the available equipment s in the nuclear medicine centers, together with the neck-thyroid simulators elaborated by the ININ to calibrate the gamma cameras. The gamma cameras have among their component elements that conform spectrometric systems like the employees in the evaluation of the internal incorporation for direct measurements, reason why, besides their use for diagnostic for image, they can be calibrated with anthropomorphic simulators and also with punctual sources for the quantification of the radionuclides activity distributed homogeneously in the human body, or located in specific organs. Inside the project IAEA-ARCAL-RLA/9/049-LXXVIII -Procedures harmonization of internal dosimetry- where 9 countries intervened (Argentina, Brazil, Colombia, Cuba, Chile, Mexico, Peru, Uruguay and Spain). It was developed a protocol of cameras gamma calibration for the determination in vivo of radionuclides. The protocol is the base to establish and integrated network in Latin America to attend in response to emergencies, using nuclear medicine centers of public hospitals of the region. The objective is to achieve the appropriate radiological protection of the workers, essential for the sure and acceptable radiation use, the radioactive materials and the nuclear energy. (Author)

  20. Value of coincidence gamma camera PET for diagnosing head and neck tumors: functional imaging and image coregistration

    International Nuclear Information System (INIS)

    Dresel, S.; Brinkbaeumer, K.; Schmid, R.; Hahn, K.

    2001-01-01

    54 patients suffering from head and neck tumors (30 m, 24 f, age: 32-67 years) were examined using dedicated PET and coincidence gamma camera PET after injection of 185-350 MBq [ 18 F]FDG. Examinations were carried out on the dedicated PET first (Siemens ECAT Exact HR+) followed by a scan on the coincidence gamma camera PET (Picker Prism 2000 XP-PCD, Marconi Axis g-PET 2 AZ). Dedicated PET was acquired in 3D mode, coincidence gamma camera PET was performed in list mode using an axial filter. Reconstruction of data was performed iteratively on both, dedicated PET and coincidence gamma camera PET. All patients received a CT scan in multislice technique (Siemens Somatom Plus 4, Marconi MX 8000). Image coregistration was performed on an Odyssey workstation (Marconi). All findings have been verified by the gold standard histology or in case of negative histology by follow-up. Results: Using dedicated PET the primary or recurrent lesion was correctly diagnosed in 47/48 patients, using coincidence gamma camera PET in 46/48 patients and using CT in 25/48 patients. Metastatic disease in cervical lymph nodes was diagnosed in 17/18 patients with dedicated PET, in 16/18 patients with coincidence gamma camera PET and in 15/18 with CT. False-positive results with regard to lymph node metastasis were seen with one patient for dedicated PET and hybrid PET, respectively, and with 18 patients for CT. In a total of 11 patients unknown metastatic lesions were seen with dedicated PET and with coincidence gamma camera PET elsewhere in the body (lung: n = 7, bone: n = 3, liver: n = 1). Additional malignant disease other than the head and neck tumor was found in 4 patients. (orig.) [de

  1. Development of Camera Electronics for the Advanced Gamma-ray Imaging System (AGIS)

    Science.gov (United States)

    Tajima, Hiroyasu

    2009-05-01

    AGIS, a next generation of atmospheric Cherenkov telescope arrays, aims to achieve a sensitivity level of a milliCrab for gamma-ray observations in in the energy band of 40 GeV to 100 TeV. Such improvement requires cost reduction of individual components with high reliability in order to equip the order of 100 telescopes necessary to achieve the sensitivity goal. We are exploring several design concepts to reduce the cost of camera electronics while improving their performance. We have developed test systems for some of these concepts and are testing their performance. Here we present test results of the test systems.

  2. Computer assisted collimation gamma camera: A new approach to imaging contaminated tissues

    International Nuclear Information System (INIS)

    Quartuccio, M.; Franck, D.; Pihet, P.; Begot, S.; Jeanguillaume, C.

    2000-01-01

    Measurement systems with the capability of imaging tissues contaminated with radioactive materials would find relevant applications in medical physics research and possibly in health physics. The latter in particular depends critically on the performance achieved for sensitivity and spatial resolution. An original approach of computer assisted collimation gamma camera (French acronym CACAO) which could meet suitable characteristics has been proposed elsewhere. CACAO requires detectors with high spatial resolution. The present work was aimed at investigating the application of the CACAO principle on a laboratory testing bench using silicon detectors made of small pixels. (author)

  3. Computer assisted collimation gamma camera: A new approach to imaging contaminated tissues

    Energy Technology Data Exchange (ETDEWEB)

    Quartuccio, M.; Franck, D.; Pihet, P.; Begot, S.; Jeanguillaume, C

    2000-07-01

    Measurement systems with the capability of imaging tissues contaminated with radioactive materials would find relevant applications in medical physics research and possibly in health physics. The latter in particular depends critically on the performance achieved for sensitivity and spatial resolution. An original approach of computer assisted collimation gamma camera (French acronym CACAO) which could meet suitable characteristics has been proposed elsewhere. CACAO requires detectors with high spatial resolution. The present work was aimed at investigating the application of the CACAO principle on a laboratory testing bench using silicon detectors made of small pixels. (author)

  4. Study of the feasibility of a compact gamma camera for real-time cancer assessment

    CERN Document Server

    Caballero Ontanaya, Luis

    2017-01-01

    Results from the simulations of a Compton gamma camera based on compact configuration of detectors consisting in two detection modules, each of them having two stages of high-resolution position- and energy sensitive radiation detectors operated in time-coincidence are presented. Monolithic scintillation crystals instead of pixelated crystals in order to reduce dead areas have been simulated. In order to study the system feasibility to produce real-time images, different setups are considered. Performance in terms of acquisition times have been calculated to determine the real-time capabilities and limitations of such a system.

  5. Measurement of total-body cobalt-57 vitamin B12 absorption with a gamma camera

    International Nuclear Information System (INIS)

    Cardarelli, J.A.; Slingerland, D.W.; Burrows, B.A.; Miller, A.

    1985-01-01

    Previously described techniques for the measurement of the absorption of [ 57 Co]vitamin B 12 by total-body counting have required an iron room equipped with scanning or multiple detectors. The present study uses simplifying modifications which make the technique more available and include the use of static geometry, the measurement of body thickness to correct for attenuation, a simple formula to convert the capsule-in-air count to a 100% absorption count, and finally the use of an adequately shielded gamma camera obviating the need of an iron room

  6. Easy method to measure radioactive waste with a gamma-camera detector

    International Nuclear Information System (INIS)

    Murat, C.; Barrau, C.

    2007-01-01

    The aim of this technical note is to evaluate an easy method to measure 99m Tc samples with an activity of 1000, 100 and 10 Bq/L. This study is performed with a gamma camera detector in two departments of nuclear medicine in Avignon and in Nimes. We develop a procedure to measure 99m Tc radioactive waste at the two hospitals output in accordance with the D.G.S./D.H.O.S. no. 2001/323 circular requests of the Ministry for Employment and Solidarity. (authors)

  7. A 3D high-resolution gamma camera for radiopharmaceutical studies with small animals

    CERN Document Server

    Loudos, G K; Giokaris, N D; Styliaris, E; Archimandritis, S C; Varvarigou, A D; Papanicolas, C N; Majewski, S; Weisenberger, D; Pani, R; Scopinaro, F; Uzunoglu, N K; Maintas, D; Stefanis, K

    2003-01-01

    The results of studies conducted with a small field of view tomographic gamma camera based on a Position Sensitive Photomultiplier Tube are reported. The system has been used for the evaluation of radiopharmaceuticals in small animals. Phantom studies have shown a spatial resolution of 2 mm in planar and 2-3 mm in tomographic imaging. Imaging studies in mice have been carried out both in 2D and 3D. Conventional radiopharmaceuticals have been used and the results have been compared with images from a clinically used system.

  8. Hydra phantom applicability for carrying out tests of field uniformity in gamma cameras

    International Nuclear Information System (INIS)

    Aragao Filho, Geraldo L.; Oliveira, Alex C.H.

    2014-01-01

    Nuclear Medicine is a medical modality that makes use of radioactive material 'in vivo' in humans, making them a temporary radioactive source. The radiation emitted by the patient's body is detected by a specific equipment, called a gamma camera, creates an image showing the spatial and temporal biodistribution of radioactive material administered to the patient. Therefore, it's of fundamental importance a number of specific measures to make sure that procedure be satisfactory, called quality control. To Nuclear Medicine, quality control of gamma camera has the purpose of ensuring accurate scintillographic imaging, truthful and reliable for the diagnosis, guaranteeing visibility and clarity of details of structures, and also to determine the frequency and the need for preventive maintenance of equipment. To ensure the quality control of the gamma camera it's necessary to use some simulators, called phantom, used in Nuclear Medicine to evaluate system performance, system calibration and simulation of injuries. The goal of this study was to validate a new simulator for nuclear medicine, the Hydra phantom. The phantom was initially built for construction of calibration curves used in radiotherapy planning and quality control in CT. It has similar characteristics to specific phantoms in nuclear medicine, containing inserts and water area. Those inserts are regionally sourced materials, many of them are already used in the literature and based on information about density and interaction of radiation with matter. To verify its efficiency in quality control in Nuclear Medicine, was performed a test for uniformity field, one of the main tests performed daily, so we can verify the ability of the gamma camera to reproduce a uniform distribution of the administered activity in the phantom, been analysed qualitatively, through the image, and quantitatively, through values established for Central Field Of View (CFOV) and Useful Field Of View (UFOV). Also, was evaluated their

  9. Approaches to contamination problems of agricultural land using Na(I) Tl spectrometer and gamma camera

    International Nuclear Information System (INIS)

    Yin, Yong-Gen; Suzui, Nobuo; Kawachi, Naoki; Ishii, Satomi; Fujimaki, Shu; Yamaguchi, Mitsutaka; Tanoi, Keitaro; Nakanishi, Tomoko M.; Chino, Mitsuo; Nakamura, Shin-ichi; Watabe, Hiroshi; Yamamoto, Seiichi

    2012-01-01

    The severe accident of Fukushima Daiichi Nuclear Power Plant made a large area of agricultural land contaminated with radioactive cesium (Cs-134 and 137). Quantitative analysis for radioactivity (discriminating for Cs-134 and Cs-137) taken in vegetables from the land was carried out using NaI (Tl) scintillation spectrometer. Development of gamma camera for their imaging due to Cs 137 was performed. The shape of the peaks in the spectrum, baseline suppression, a solution of lines overlapping, enhancement of high-resolution were studied. Furthermore, the effect of water on cesium absorbing and transferring process from the root to the tissue was studied. (S. Ohno)

  10. Survey of potential use of dynamic line phantom for quality control of Gamma camera

    International Nuclear Information System (INIS)

    Trindev, P.; Ozturk, N.

    2004-01-01

    Different phantoms, used to evaluate the essential for image quality parameters of gamma cameras in order to avoid artefacts, are presented. The prices are significant and it is a sensible approach to optimise the type and number of phantoms necessary for quality control. Among all phantoms the price of 'Dynamic Line Phantom' (DLP) is impressive, but it is announced to substitute several 'passive' and 'active' phantoms. The goal of this paper is to justify this statement. The programs, based on image profile are discussed in the paper and the practical uses of the different programs are given

  11. SPM analysis of cerebrovascular reserve capacity after stimulation with acetazolamide measured by Tc-99m ECD SPECT in normal brain MRI patient

    Energy Technology Data Exchange (ETDEWEB)

    Lee, M. H.; Yoon, S. N.; Yoon, J. K.; Cho, C. W. [College of Medicine, Univ. of Ajou, Suwon (Korea, Republic of)

    2003-07-01

    This study was undertaken to evaluate normal response of acetazolamide in normal individuals, whose brain MRI is normal, using SPM99. In total, 10 Tc- 99m ECD brain SPECT were evaluated retrospectively. The half of the patients were male. Their mean age was 47.1 years old with a range of 33-61 years. They all visited our neurology department to evaluate stroke symptom. Their brain MRI was normal. Rest/acetazolamide brain SPECT was perfomed using Tc-99m ECD and the sequential injection and subtraction method. SPECT was acquired using fanbeam collimators and triple-head gamma camera (MultiSPECT III, Siemens medical systems, Inc. Hoffman Estates, III, USA). Chang's attenuation correction was applied their brain SPECT revealed normal rCBF pattern in visual analysis by two nuclear physician and they were diagnosed clinically normal. Using SPM method, we compared rest brain SPECT images with those of acetazolamide brain SPECT and measured the extent of the area with significant perfusion change (P<0.05) in predefined 34 cerebral regions. Acetazolamide brain SPECT showed no significant decreased region in comparison to rest brain SPECT. Only small portion of left mid temporal gyrus revealed increased rCBF on acetazolamide brain SPECT in comparison to rest brain SPECT. It apperas that there is no significant change in rCBF between rest and acetazolamide brain SPECT using Tc-99m ECD. The small number of this study is limitation of our study.

  12. Study of a new architecture of gamma cameras with Cd/ZnTe/CdTe semiconductors; Etude d'une nouvelle architecture de gamma camera a base de semi-conducteurs CdZnTe /CdTe

    Energy Technology Data Exchange (ETDEWEB)

    Guerin, L

    2007-11-15

    This thesis studies new semi conductors for gammas cameras in order to improve the quality of image in nuclear medicine. The chapter 1 reminds the general principle of the imaging gamma, by describing the radiotracers, the channel of detection and the types of Anger gamma cameras acquisition. The physiological, physical and technological limits of the camera are then highlighted, to better identify the needs of future gamma cameras. The chapter 2 is dedicated to a bibliographical study. At first, semi-conductors used in imaging gamma are presented, and more particularly semi-conductors CDTE and CdZnTe, by distinguishing planar detectors and monolithic pixelated detectors. Secondly, the classic collimators of the gamma cameras, used in clinical routine for the most part of between them, are described. Their geometry is presented, as well as their characteristics, their advantages and their inconveniences. The chapter 3 is dedicated to a state of art of the simulation codes dedicated to the medical imaging and the methods of reconstruction in imaging gamma. These states of art allow to introduce the software of simulation and the methods of reconstruction used within the framework of this thesis. The chapter 4 presents the new architecture of gamma camera proposed during this work of thesis. It is structured in three parts. The first part justifies the use of semiconducting detectors CdZnTe, in particular the monolithic pixelated detectors, by bringing to light their advantages with regard to the detection modules based on scintillator. The second part presents gamma cameras to base of detectors CdZnTe (prototypes or commercial products) and their associated collimators, as well as the interest of an association of detectors CdZnTe in the classic collimators. Finally, the third part presents in detail the HiSens architecture. The chapter 5 describes both software of simulation used within the framework of this thesis to estimate the performances of the Hi

  13. Two-dimensional diced scintillator array for innovative, fine-resolution gamma camera

    International Nuclear Information System (INIS)

    Fujita, T.; Kataoka, J.; Nishiyama, T.; Ohsuka, S.; Nakamura, S.; Yamamoto, S.

    2014-01-01

    We are developing a technique to fabricate fine spatial resolution (FWHM<0.5mm) and cost-effective photon counting detectors, by using silicon photomultipliers (SiPMs) coupled with a finely pixelated scintillator plate. Unlike traditional X-ray imagers that use a micro-columnar CsI(Tl) plate, we can pixelate various scintillation crystal plates more than 1 mm thick, and easily develop large-area, fine-pitch scintillator arrays with high precision. Coupling a fine pitch scintillator array with a SiPM array results in a compact, fast-response detector that is ideal for X-ray, gamma-ray, and charged particle detection as used in autoradiography, gamma cameras, and photon counting CTs. As the first step, we fabricated a 2-D, cerium-doped Gd 3 Al 2 Ga 3 O 12 (Ce:GAGG) scintillator array of 0.25 mm pitch, by using a dicing saw to cut micro-grooves 50μm wide into a 1.0 mm thick Ce:GAGG plate. The scintillator plate is optically coupled with a 3.0×3.0mm pixel 4×4 SiPM array and read-out via the resistive charge-division network. Even when using this simple system as a gamma camera, we obtained excellent spatial resolution of 0.48 mm (FWHM) for 122 keV gamma-rays. We will present our plans to further improve the signal-to-noise ratio in the image, and also discuss a variety of possible applications in the near future

  14. Three-layer GSO depth-of-interaction detector for high-energy gamma camera

    International Nuclear Information System (INIS)

    Yamamoto, S.; Watabe, H.; Kawachi, N.; Fujimaki, S.; Kato, K.; Hatazawa, J.

    2014-01-01

    Using Ce-doped Gd 2 SiO 5 (GSO) of different Ce concentrations, three-layer DOI block detectors were developed to reduce the parallax error at the edges of a pinhole gamma camera for high-energy gamma photons. GSOs with Ce concentrations of 1.5 mol% (decay time ∼40 ns), 0.5 mol% crystal (∼60 ns), 0.4 mol% (∼80 ns) were selected for the depth of interaction (DOI) detectors. These three types of GSOs were optically coupled in the depth direction, arranged in a 22×22 matrix and coupled to a flat panel photomultiplier tube (FP-PMT, Hamamatsu H8500). Sizes of these GSO cells were 1.9 mm×1.9 mm×4 mm, 1.9 mm×1.9 mm×5 mm, and 1.9 mm×1.9 mm×6 mm for 1.5 mol%, 0.5 mol%, and 0.4 mol%, respectively. With these combinations of GSOs, all spots corresponding to GSO cells were clearly resolved in the position histogram. Pulse shape spectra showed three peaks for these three decay times of GSOs. The block detector was contained in a 2-cm-thick tungsten shield, and a pinhole collimator with a 0.5-mm aperture was mounted. With pulse shape discrimination, we separated the point source images of the Cs-137 for each DOI layer. The point source image of the lower layer was detected at the most central part of the field-of-view, and the distribution was the smallest. The point source image of the higher layer was detected at the most peripheral part of the field-of-view, and the distribution was widest. With this information, the spatial resolution of the pinhole gamma camera can be improved. We conclude that DOI detection is effective for pinhole gamma cameras for high energy gamma photons

  15. Radiopharmaceutical activities administered for diagnostic procedures in nuclear medicine in the first six months of the gamma camera use in the Clinical Center of Montenegro - Podgorica

    International Nuclear Information System (INIS)

    Antovic, Nevenka; Aligrudic, Irena

    2008-01-01

    Nuclear medicine procedures have carried out in the Clinical Center of Montenegro - Podgorica since 2006 by the dual-headed SPECT and Digital gamma camera NUCLINE Spirit DH-V. In the first six months of the gamma camera use (from September 2006 to March 2007) examinations of skeleton, kidneys, thyroid and lung were performed. For diagnostic skeletal imaging (102 patients) the radiopharmaceutical 99m Tc-MDP is used, and administered activities were in the range from 555 to 740 MBq. For thyroid imaging (203 patients) 99m Tc-pertechnetate is used, and administered activities were in the range (37-111) MBq. Lung imaging is performed for 3 patients, using 99m Tc-MAA and administered activities in the range (111-185) MBq. Renal imaging is carried out for 72 patients: 42 dynamic studies of kidneys were performed with 99m Tc-DTPA and administered activities from 207 to 282 MBq, and 30 static kidneys scintigraphies were performed using the radiopharmaceutical 99m Tc-DMSA. 6 patients in the last mentioned group were children with year of birth between 2000 and 2006, and administered activities were from 16.6 to 55.5 MBq. In the same group, activities 28.5 MBq, 74.4 MBq and 120 MBq were administered to three patients with age between 6 and 18 years, and in the other cases, administered activities to the patients (adults) were in the range (59.2 to 196) MBq. The administered activities presented here are basis for further estimations of cumulated activity and absorbed dose to the various organs, which is useful for comparison of the average dose to patient organs in various nuclear medicine procedures and calculation of effective dose equivalent and total effective dose, significant for an estimation of potential risk due to the radioactivity administered to a patient during nuclear medicine procedures. It is very important for procedures optimization and improvement of the radiation protection. (author)

  16. Attenuation maps for SPECT determined using cone beam transmission computed tomography

    International Nuclear Information System (INIS)

    Manglos, S.H.; Bassano, D.A.; Duxbury, C.E.; Capone, R.B.

    1990-01-01

    This paper presents a new method for measuring non-uniform attenuation maps, using a cone beam geometry CT scan acquired on a standard rotating gamma camera normally used for SPECT imaging. The resulting map is intended for use in non-uniform attenuation compensation of SPECT images. The method was implemented using a light-weight point source holder attached to the camera. A cone beam collimator may be used on the gamma camera, but the cone beam CT scans may also be acquired without collimator. In either implementation, the advantages include very high efficiency and resolution limited not by the collimator but by the intrinsic camera resolution (about 4 mm). Several phantoms tested the spatial uniformity, noise, linearity as a function of attenuation coefficient, and spatial resolution. Good quality attenuation maps were obtained, at least for the central slices where no truncation was present

  17. Brain SPECT in psychiatry: Delusion or reality?

    International Nuclear Information System (INIS)

    Pavel, D.G.; Davis, G.; Epstein, P.; Kohn, R.; Antonino, F.; Devore-Best, S.; Craita, I.; Liu, P.

    2002-01-01

    Aim: The need for functional information is becoming increasingly evident for proper therapeutic approaches to the treatment and follow up of psychiatric diseases. While data on this subject already exists, there is a general lack of consensus about the use of brain SPECT in this domain and also a considerable negative prejudice due to a number of factors including poor quality imaging and unrealistic expectations. Based on a large group of brain SPECT-s performed over the past 3 years we attempted to sort and refine the indications for SPECT in psychiatry. Materials and Methods: High resolution brain SPECT was performed with triple head gamma camera, super-high resolution fan beam collimator and Tc-HMPAO. A comprehensive semiquantitative color, 3D surface as well as multi-thresholded volume display was routinely used and supplemented by automatic realignment in case of longitudinal follow-up. Results: 470 brain SPECT-s done on 432 patients were all referred by psychiatrists or neuro-psychiatrists for a wide spectrum of psychiatric diseases and ranged in age from 7 to 88 years. The most common primary reasons for referral were : attention deficit hyperactive disorder (ADHD); anxiety; obsessive-compulsive disease, depression (refractory, chronic, bipolar ), impulse control problems; oppositional defiance, post traumatic brain injury; seizures, learning difficulties, pervasive development disorders, memory loss and differential of dementia. Among common denominators were long duration of the disease, unresponsiveness to treatment, worsening of clinical status, and presence of multiple conditions at the same time. The multiparametric display used enabled a comprehensive evaluation of the brain volume which included the hemispheric surfaces; the basal ganglia (striatum) and the thalamus, several components of the limbic and paralimbic systems: anterior and posterior cingulate and their respective subdivisions, insula-s and their subdivisions, apical and mesial

  18. SPECT/CT co-registration of nuclear medicine studies and technologists: challenges and victories

    International Nuclear Information System (INIS)

    Cameron, P.J.

    2002-01-01

    Full text: A dual modality SPECT/CT gamma camera was installed in the Department of Nuclear Medicine at Fremantle Hospital, WA in 2000. The challenges were satisfying the requirements of the Radiological Advisory Council of WA with respect to room modifications and presence of a radiographer during CT acquisitions and once installation was complete, learning to operate the camera in dual modality mode. The victories are making CT/SPECT acquisitions a simple and routine procedure and the impact of the co-registered studies in both diagnostic and therapeutic applications in our practice. Copyright (2002) The Australian and New Zealand Society of Nuclear Medicine Inc

  19. PET with a coincidence gamma camera: results in selected oncological questions

    International Nuclear Information System (INIS)

    Lauer, I.; Haase, A; Adam, S.; Prueter, I.; Richter, E.; Baehre, M.

    2001-01-01

    Since early 1997, about 1660 investigations with coincidence gamma camera PET (CGC-PET) have been performed in our department, mostly undertaken for oncological questions. Based on these data, several retrospective and prospective studies were performed. In the following, the results in CUP (cancer of unknown primary) syndrome, melanoma and malignant lymphoma are presented. Methods: CGC-PET was performed after application of 250-350 MBq [ 18 F]FDG using a coincidence double head gamma camera with 19 mm Nal cristal. CUP-Syndrome: After completing conventional diagnostic procedures, 32 patients have been examined in a prospective study, including 25 patients with recently detected CUP and 7 patients undergoing restaging after therapy. Localization of the primary tumor was successful in 12 (38%) cases. Melanoma: We evaluated 50 studies in 41 patients suffering from melanoma, retrospectively. CGC-PET showed a sensitivity of 76%, and a specificity of 94%. In comparison to conventional diagnostic methods, CGC-PET delineated important additional information in 16%. CGC-PET was superior to morphological diagnostic tools in the differentiation between residual scar tissue and active tumor following immunochemotherapy. Malignant lymphoma: 29 CGC-PET in 29 patients were performed for staging of malignant lymphoma, sensitivity was 86% versus 88% for CT. Overall CGC-PET showed additional information to conventional diagnostic methods, but revealed problems in detecting small infiltrations of organs. In restaging malignant melanoma (26 patients, 33 studies), specificity of CGC-PET was superior to conventional diagnostics (92% versus 35%). (orig.) [de

  20. F-18 FDG PET with coincidence detection, dual-head gamma camera, initial experience in oncology

    Energy Technology Data Exchange (ETDEWEB)

    Chu, J.M.G.; Pocock, N.; Quach, T.; Camden, B.M.C. [Liverpool Health Services, Liverpool, NSW (Australia). Department of Nuclear Medicine and Clinical Ultrasound

    1998-06-01

    Full text: The development of Co-incidence Detection (CD) in gamma camera technology has allowed the use of positron radiopharmaceuticals in clinical practice without dedicated PET facilities. We report our initial experience of this technology in Oncological applications. All patients were administered 200 MBq of F- 18 FDG intravenously in a fasting state, with serum glucose below 8.9 mmol/L., and hydration well maintained. Tomography was performed using an ADAC Solus Molecular Co-incidence Detection (MCD) dual-head gamma camera, 60 minutes after administration and immediately after voiding. Tomography of the torso required up to three collections depending on the length of the patient, with each collection requiring 32 steps of 40 second duration, and a 50% overlap. Tomography of the brain required a single collection with 32 steps of 80 seconds. Patients were scanned in the supine position. An iterative reconstruction algorithm was employed without attenuation correction. All patients had histologically confirmed malignancy. Scan findings were correlated with results of all conventional diagnostic imaging procedures that were pertinent to the evaluation and management of each individual patient`s disease. Correlation with tumour type and treatment status was also undertaken. F-18 FDG uptake as demonstrated by CD-PET was increased in tumour bearing sites. The degree of increased uptake varied with tumour type and with treatment status. Our initial experience with CD-PET has been very encouraging, and has led us to undertake prospective short and long term studies to define its role in oncology

  1. Defining the lung outline from a gamma camera transmission attenuation map

    International Nuclear Information System (INIS)

    Fleming, John S; Pitcairn, Gary; Newman, Stephen

    2006-01-01

    Segmentation of the lung outline from gamma camera transmission images of the thorax is useful in attenuation correction and quantitative image analysis. This paper describes and compares two threshold-based methods of segmentation. Simulated gamma camera transmission images of test objects were used to produce a knowledge base of the variation of threshold defining the lung outline with image resolution and chest wall thickness. Two segmentation techniques based on global (GT) and context-sensitive (CST) thresholds were developed and evaluated in simulated transmission images of realistic thoraces. The segmented lung volumes were compared to the true values used in the simulation. The mean distances between segmented and true lung surface were calculated. The techniques were also applied to three real human subject transmission images. The lung volumes were estimated and the segmentations were compared visually. The CST segmentation produced significantly superior segmentations than the GT technique in the simulated data. In human subjects, the GT technique underestimated volumes by 13% compared to the CST technique. It missed areas that clearly belonged to the lungs. In conclusion, both techniques segmented the lungs with reasonable accuracy and precision. The CST approach was superior, particularly in real human subject images

  2. Realisation of a gamma emission tomograph by a servo-controlled camera and bed

    International Nuclear Information System (INIS)

    Guzman-Torres, D.R.

    1980-07-01

    We took part in the building of a transverse axial emission tomograph intended for nuclear medicine. The following three points were dealt with: mathematical, choice of processing algorithm; electronic, development of equipment; experimental, testing of the system built. On the mathematical side, following a survey of reconstruction methods, we studied the use of a reconstruction algorithm after filtering of the projections by convolution which gives a good spatial resolution. We also proposed a means to solve the computing time/quality of image problem, leading to a satisfactory result within a shorter total investigation time. In this way the computing time has been reduced by a factor three. In the electronics field we built an interface between the bed, the gamma camera and the computer already in the laboratory. The present instrument corresponds to version no. 2. The system control the bed and gamma camera which are operated from the computer. Experimentally we were able on checking the calculations with a phantom made up of small emitting sources, to prove by finding the exact spot our ability to locate active foci on the patient. While the results obtained are encouraging from the image restitution viewpoint, the study of problems related to self-absorption inside the organ and those of statistical noise have still to be continued [fr

  3. SiPM arrays and miniaturized readout electronics for compact gamma camera

    Energy Technology Data Exchange (ETDEWEB)

    Dinu, N., E-mail: dinu@lal.in2p3.fr [Laboratory of Linear Accelerator, IN2P3, CNRS, Orsay (France); Imando, T. Ait; Nagai, A. [Laboratory of Linear Accelerator, IN2P3, CNRS, Orsay (France); Pinot, L. [Laboratory of Imaging and Modelisation in Neurobiology and Cancerology, IN2P3, CNRS, Orsay (France); Puill, V. [Laboratory of Linear Accelerator, IN2P3, CNRS, Orsay (France); Callier, S. [Omega Microelectronics Group, CNRS, Palaiseau (France); Janvier, B.; Esnault, C.; Verdier, M.-A. [Laboratory of Imaging and Modelisation in Neurobiology and Cancerology, IN2P3, CNRS, Orsay (France); Raux, L. [Omega Microelectronics Group, CNRS, Palaiseau (France); Vandenbussche, V.; Charon, Y.; Menard, L. [Laboratory of Imaging and Modelisation in Neurobiology and Cancerology, IN2P3, CNRS, Orsay (France)

    2015-07-01

    This article reports on the design and features of a very compact and light gamma camera based on SiPM arrays and miniaturized readout electronics dedicated to tumor localization during radio-guided cancer surgery. This gamma camera, called MAGICS, is composed of four (2×2) photo-detection elementary modules coupled to an inorganic scintillator. The 256 channels photo-detection system covers a sensitive area of 54×53 m{sup 2}. Each elementary module is based on four (2×2) SiPM monolithic arrays, each array consisting of 16 SiPM photo-sensors (4×4) with 3×3 mm{sup 2} sensitive area, coupled to a miniaturized readout electronics and a dedicated ASIC. The overall dimensions of the electronics fit the size of the detector, enabling to assemble side-by-side several elementary modules in a close-packed arrangement. The preliminary performances of the system are very encouraging, showing an energy resolution of 9.8% and a spatial resolution of less than 1 mm at 122 keV.

  4. Survey of Current Status of Quality Control of Gamma Cameras in Republic of Korea

    International Nuclear Information System (INIS)

    Choe, Jae Gol; Joh, Cheol Woo

    2008-01-01

    It is widely recognized that good quality control (QC) program is essential for adequate imaging diagnosis using gamma camera. The purpose of this study is to survey the current status of QC of gamma cameras in Republic of Korea for implementing appropriate nationwide quality control guidelines and programs. A collection of data is done for personnel, equipment and appropriateness of each nuclear medicine imaging laboratory's' quality control practice. This survey is done by collection of formatted questionnaire by mails, e mails or interviews. We also reviewed the current recommendations concerning quality assurance by international societies. This survey revealed that practice of quality control is irregular and not satisfactory. The irregularity of the QC practice seems due partly to the lack of trained personnel, equipment, budget, time and hand-on guidelines. The implementation of QC program may cause additional burden to the hospitals, patients and nuclear medicine laboratories. However, the benefit of a good QC program is obvious that the hospitals can provide good quality nuclear medicine imaging studies to the patients. It is important to use least cumbersome QC protocol, to educate the nuclear medicine and hospital administrative personnel concerning QC, and to establish national QC guidelines to help each individual nuclear medicine laboratory

  5. Radioimmunological determination of alphafetoprotein and gamma camera scintigraphy in patients with tumours of the testes

    International Nuclear Information System (INIS)

    Milkov, V.; Sultanov, S.

    1989-01-01

    By means of radioimmunological method the blood serum concentrations of alphafetoprotein (AFP) were investigated in 35 patients with histologically confirmed tumours of the testes prior to surgical intervention. Parallely in all patients gamma camera scintigraphy of the testes was performed. Seven of all investigated 15 patients with seminoma of the testes had increased concentrations of AFP in the blood serum. In 7 of the examinated 10 patients with diagnosis teratoma of the testes increased blood serum concentrations of AFP were established, while 6 of the examined patients with embryonic tumour of the testis had increased blood serum concentrations of AFP. In comparison with the results established in the control group of 30 healthy males, this increase of AFP was statistically reliable. All examined patients showed positive scintigraphic findings, which confirmed the diagnosis of tumour of the testes. It is concluded that the parallel determination of blood serum AFP and gamma camera investigation of the testes could be successfully apllied in the diagnosis of these malignant diseases

  6. Characteristics of Multihole Collimator Gamma Camera Simulation Modeled Using MCNP5

    International Nuclear Information System (INIS)

    Saripan, M. I.; Mashohor, S.; Adnan, W. A. Wan; Marhaban, M. H.; Hashim, S.

    2008-01-01

    This paper describes the characteristics of the multihole collimator gamma camera that is simulated using the combination of the Monte Carlo N-Particles Code (MCNP) version 5 and in-house software. The model is constructed based on the GCA-7100A Toshiba Gamma Camera at the Royal Surrey County Hospital, Guildford, Surrey, UK. The characteristics are analyzed based on the spatial resolution of the images detected by the Sodium Iodide (NaI) detector. The result is recorded in a list-mode file referred to as a PTRAC file within MCNP5. All pertinent nuclear reaction mechanisms, such as Compton and Rayleigh scattering and photoelectric absorption are undertaken by MCNP5 for all materials encountered by each photon. The experiments were conducted on Tl-201, Co-57, Tc-99 m and Cr-51 radio nuclides. The comparison of full width half maximum value of each datasets obtained from experimental work, simulation and literature are also reported in this paper. The relationship of the simulated data is in agreement with the experimental results and data obtained in the literature. A careful inspection at each of the data points of the spatial resolution of Tc-99 m shows a slight discrepancy between these sets. However, the difference is very insignificant, i.e. less than 3 mm only, which corresponds to a size of less than 1 pixel only (of the segmented detector)

  7. Gamma camera imaging of bilateral adrenocartical hyperplasia and adrenal tumors in the dog

    International Nuclear Information System (INIS)

    Mulnix, J.A.; Van den Brom, W.E.; Lubberink, A.A.; de Bruijne, J.J.; Rijnberk, A.

    1976-01-01

    Gamma camera imaging of the adrenal glands was done in 8 dogs with hyperadrenocorticism and 4 normal dogs given intravenous injections of 131I-19-iodocholesterol. In normal dogs, both adrenal glands could be visualized separately, and there was no difficulty in distinguishing among the images of normal glands, hyperplastic glands, and functional adrenal tumors. In addition, gamma camera imaging enabled the correct surgical site to be selected for removal of adrenal tumors. Hyperadrenocorticism was diagnosed in 8 dogs by evaluation of urinary 17-hydroxycorticosteroid (OHCS) excretion rates, urinary 17-OHCS and plasma 11 beta-OHCS responses to dexamethasone suppression of endogenous adrenocorticotropin (ACTH) secretion, and plasma 11 beta-OHCS response to intravenous administration of ACTH. Base line 17-OHCS excretion increased in 5 of the 8 dogs. Plasma 11 beta-OHCS concentrations were not decreased by dexamethasone administration in the 4 dogs subsequently found to have adrenal tumors; however, there was an exaggerated increase in plasma 11 beta-OHCS concentration after administration of ACTH in 3 of the 4 dogs which had bilateral adrenocortical hyperplasia

  8. Comparison of the barium test meal and the gamma camera scanning technic in measuring gastric emptying

    Energy Technology Data Exchange (ETDEWEB)

    Perkel, M.S.; Fajman, W.A.; Hersh, T.

    1981-09-01

    In 21 patients with nonresected stomachs and symptoms of delayed gastric emptying, obstruction was excluded by upper gastrointestinal series and upper endoscopy; all had abnormal results of barium test meal (BTM) study. Each had repeat BTM after the administration of 10 mg of metoclopramide. Each patient also had two gamma camera studies after a technetium Tc 99m sulfur colloid labeled meal; normal saline or metoclopramide was administered before each test in a blinded and random manner. Half-time (T 1/2) and percentage of isotope remaining at six hours (GC6) were recorded. Ten asymptomatic controls had a gamma camera scanning study, and seven of these had a BTM. Nine of 19 patients had a T 1/2 in the normal range, and in 12 of 19 patients the GC6 was in the normal range. The magnitude of retention of barium at six hours on the BTM did not correlate with the T 1/2 (r = 0.076) or the GC6 (r = 0.296). Thus, these tests were not comparable in this study. By regression analysis, a significant reduction was shown in the amount of retained food and barium (P < .01), the T 1/2 (P < .01), and the GC6 (P < .01) after intramuscular administration of metoclopramide, indicating that both tests were able to evaluate the effects of this drug.

  9. Comparison of the barium test meal and the gamma camera scanning technic in measuring gastric emptying

    Energy Technology Data Exchange (ETDEWEB)

    Perkel, M.S.; Fajman, W.A.; Hersh, T.; Moore, C.; Davidson, E.D.; Haun, C.

    1981-09-01

    In 21 patients with nonresected stomachs and symptoms of delayed gastric emptying, obstruction was excluded by upper gastrointestinal series and upper endoscopy; all had abnormal results of barium test meal (BTM) study. Each had repeat BTM after the administration of 10 mg of metoclopramide. Each patient also had two gamma camera studies after a technetium Tc 99m sulfur colloid labeled meal; normal saline or metoclopramide was administered before each test in a blinded and random manner. Half-time (T1/2) and percentage of isotope remaining at six hours (GC6) were recorded. Ten asymptomatic controls had a gamma camera scanning study, and seven of these had a BTM. Nine of 19 patients had a T1/2 in the normal range, and in 12 of 19 patients the GC6 was in the normal range. The magnitude of retention of barium at six hours on the BTM did not correlate with the T1/2 (r . 0.076) or the GC6 (r. 0.296). Thus, these tests were not comparable in this study. By regression analysis, a significant reduction was shown in the amount of retained food and barium (P less than .01), the T1/2 (P less than .01), and the GC6 (P less than .01) after intramuscular administration of metoclopramide, indicating that both tests were able to evaluate the effects of this drug.

  10. Expanding of FOV of NaI(Tl) gamma camera detectors-Is it possible?

    International Nuclear Information System (INIS)

    Gayshan, Vadim L.; Gektin, A.V.; Boyarintsev, A.; Pedash, V.

    2006-01-01

    Every gamma camera detector used for medical imaging of conventional design faces the problem of distorted or no information readout at the areas closer to the edge of detectors. Obtaining position and energy information becomes almost impossible at distance 0-12 of PMT size from the edge. Therefore, in some designs were proposed losing of edge energy resolution while improving in spatial uniformity when it comes to imaging at the edges. This work is dedicated to understanding of the problem, mathematical simulations, practical tests and recommendations to build detectors with larger usable FOV without increasing in dimensions. To study the problem we built the test jig with linear motion source and readout electronics to simulate gamma cameras of PMTs. Based on simulation results the idea of modifying of crystal shape combined with specific light redirection system of baffles was tested and allowed to expand usable FOV. The results are presented and showed that for traditional NaI(Tl) scintillators using 2'' PMT may be possible to obtain relatively good spatial resolution starting from 4-5mm from the edge of a detector. The question of economical efficiency of proposed method is being investigated and a special detector manufacturing technology must be developed to accommodate this. While we believe that achieved results are very important for small size detectors (<20cm) they could be beneficial even for larger detectors used in whole body imaging systems

  11. Performance evaluation of a hand-held, semiconductor (CdZnTe)-based gamma camera

    CERN Document Server

    Abe, A; Lee, J; Oka, T; Shizukuishi, K; Kikuchi, T; Inoue, T; Jimbo, M; Ryuo, H; Bickel, C

    2003-01-01

    We have designed and developed a small field of view gamma camera, the eZ SCOPE, based on use of a CdZnTe semiconductor. This device utilises proprietary signal processing technology and an interface to a computer-based imaging system. The purpose of this study was to evaluate the performance of the eZ scope in comparison with currently employed gamma camera technology. The detector is a single wafer of 5-mm-thick CdZnTe that is divided into a 16 x 16 array (256 pixels). The sensitive area of the detector is a square of dimension 3.2 cm. Two parallel-hole collimators are provided with the system and have a matching (256 hole) pattern to the CdZnTe detector array: a low-energy, high-resolution parallel-hole (LEHR) collimator fabricated of lead and a low-energy, high-sensitivity parallel-hole (LEHS) collimator fabricated of tungsten. Performance measurements and the data analysis were done according to the procedures of the NEMA standard. We also studied the long-term stability of the system with continuous use...

  12. Evaluation of a CZT gamma-ray detection module concept for SPECT

    International Nuclear Information System (INIS)

    Montemont, Guillaume; Lux, Silvere; Monnet, Olivier; Stanchina, Sylvain; Verger, Loick

    2012-01-01

    CZT detectors are the basic building block of a variety of new SPECT systems. Their modularity allows to adapt system architecture to specific applications such as cardiac, breast, brain or small animal imaging. Thanks to their high quantum yield, these direct conversion detectors exhibit better energy and spatial resolutions than usual scintillation detectors based on NaI(Tl). However, it remains often unclear if SPECT imaging really can take profit of that performance gain. We propose here to conduct a case study based on the latest results obtained in our laboratory with current state of the art ICs and CZT crystals to investigate the system performance of a classical module dimensioning of 5 mm thick CZT with a segmented anode at a 2.5 * 2.5 mm pitch. This dimensioning, though being quite conservative, allows an easy integration in terms of crystal hybridization or PCB layout but still allows to obtain impressive results. Compared with X-ray counting were the only information retrieved is the occurrence of a photon interaction, spectrometric imaging performance is not only determined by photon statistics but also by readout noise, that ultimately limits time, energy and spatial resolutions associated with each photon event. After a first part dealing with the noise performance achieved by integrated circuits and a discussion on the key limiting factors, we present the typical readout architecture used and show how the signal processing is optimized for multiple parameter estimation. In a subsequent part, multi-pixel data acquisition scheme is discussed to show how raw channel data is used to extract photon parameters (energy, time-stamp, and 3D position) while taking into account material non-uniformities. We will show how such data can be used to build images and quantify resulting improvement. Finally, we open the discussion on SPECT collimation and architecture by demonstrating with simulations how a tomographical system dimensioning depends on detector

  13. DMSA SPECT imaging using oblique reconstruction in a paediatric population - benefits and technical considerations

    International Nuclear Information System (INIS)

    Parsons, G.; Ford, M.; Crisp, J.; Bernard, E.; Howman-Giles, R.

    1997-01-01

    Full text: DMSA renal scans are frequently requested for the diagnosis and follow-up of acute pyelonephritis and cortical scarring. This study was designed to:- 1. evaluate oblique reconstruction of DMSA SPECT over standard plane reconstruction and planar imaging; and 2. report on the technical aspects important in obtaining high quality DMSA SPECT, particularly in neonates. Over seven months, 210/231 (91 %) of DMSA scans were performed with SPECT on children from age nine days to 16 years, the median age being 2.5 years. 65 patients (31 %) were under one year and 39 (18%) were under six months. Planar and SPECT imaging with standard plane reconstruction and oblique reorientation was performed on the Siemens triple-headed gamma camera. High quality SPECT images were obtained on the smallest babies using a paediatric palette, and were of comparable quality to those of older children. At the time of reporting, the nuclear medicine physician assessed the diagnostic value of the three types of date presented: (1) planar images; (2) standard plane SPECT reconstruction; and (3) oblique SPECT reconstruction. Cortical defects were identified separately for upper, middle and lower poles. Three physicians concluded that high quality SPECT is superior to planar images when assessing the renal cortex. In addition, oblique reorientation is superior to standard reconstruction, particularly at the upper and lower poles. SPECT is now performed routinely on patients of all ages, and the oblique sagittal and coronal reorientation is now used in place of the standard reconstruction

  14. Quantitative studies with the gamma-camera: correction for spatial and energy distortion

    International Nuclear Information System (INIS)

    Soussaline, F.; Todd-Pokropek, A.E.; Raynaud, C.

    1977-01-01

    The gamma camera sensitivity distribution is an important source of error in quantitative studies. In addition, spatial distortion produces apparent variations in count density which degrades quantitative studies. The flood field image takes into account both effects and is influenced by the pile-up of the tail distribution. It is essential to measure separately each of these parameters. These were investigated using a point source displaced by a special scanning table with two X, Y stepping motors of 10 micron precision. The spatial distribution of the sensitivity, spatial distortion and photopeak in the field of view were measured and compared for different setting-up of the camera and PM gains. For well-tuned cameras, the sensitivity is fairly constant, while the variations appearing in the flood field image are primarily due to spatial distortion, the former more dependent than the latter on the energy window setting. This indicates why conventional flood field uniformity correction must not be applied. A correction technique to improve the results in quantitative studies has been tested using a continuously matched energy window at every point within the field. A method for correcting spatial distortion is also proposed, where, after an adequately sampled measurement of this error, a transformation can be applied to calculate the true position of events. The knowledge of the magnitude of these parameters is essential in the routine use and design of detector systems

  15. Values of tumor markers (AFP, β-HCG and CEA) and gamma-camera scintigraphy in patients with testicular tumors

    International Nuclear Information System (INIS)

    Milkov, V.; Sultanov, S.; Tsvetkov, D.

    1989-01-01

    Complex gamma-camera and radioimmunologic study of the tumor markers AFP, β-HCG and CEA was performed in 7 patients with testicular tumors. In all tested patients gamma-camera scintigraphy of the testes clearly delineated the zone of the pathological process. Gamma-camera examination very well differentiates malignant from nonmalignant processes in the testes. The serum levels of the tumor markers AFP and β-HCG proved elevated in 3 of the tested patients during the preoperative period. The histological types of the tumors in these patients were: teratocarcinoma in one and embryonal carcinoma in the other two. It is believed that investigation of the three tumor markers may gain acceptance as additonal method in the complex diagnosis of these diseases

  16. SPECT of aged backache patients

    Energy Technology Data Exchange (ETDEWEB)

    Ito, Shigehiko; Nishikimi, Junzo; Mizuno, Naokado; Watanabe, Kentaro; Kondo, Masaki; Ozaki, Satoshi; Urasaki, Tetsuya; Muro, Toshiyuki [Prefectural Tajimi Hospital, Gifu (Japan)

    1995-12-01

    Single photon emission computed tomography (SPECT) using {sup 99m}Tc-HMDP was performed on 53 middle-aged or elderly patients (male 20, female, 33; age range, 40-80 years old) with lumbago, i.e., 25 patients with lumbar spondylosis, 15 with lumbar degenerative spondylolisthesis, 4 with spondylolytic spondylolisthesis, 3 with compression fracture, 3 with pulurent spondylitis, 2 with spondylous osteoporosis, and 1 with spinal osteodesmosis. {sup 99m}Tc-HMDP (740 MBq) was intravenously injected and regular SPECT was performed at 3 hours. Gamma camera was performed for about 10 seconds with 5deg intervals, and 36 steps (180deg) of collection was completed after about 6 minutes. The radioisotope accumulation, the presence or absence of sthenia, and its site were evaluated. Forty-seven (88.7%) patients showed excessive accumulation, i.e., 40 (75.5%) in peripheral vertebral osteophyte, 31 (58.5%) in vertebral articulations, and 10 (18.9%) in whole vertebral body. Significantly increased bilateral excessive accumulation was admitted in the vertebral articulations of sliding disc in degenerative spondylolisthesis. SPECT is considered useful in understanding the pathophysiology of degenerative lumber diseases. (S.Y.).

  17. SPECT of aged backache patients

    International Nuclear Information System (INIS)

    Ito, Shigehiko; Nishikimi, Junzo; Mizuno, Naokado; Watanabe, Kentaro; Kondo, Masaki; Ozaki, Satoshi; Urasaki, Tetsuya; Muro, Toshiyuki

    1995-01-01

    Single photon emission computed tomography (SPECT) using 99m Tc-HMDP was performed on 53 middle-aged or elderly patients (male 20, female, 33; age range, 40-80 years old) with lumbago, i.e., 25 patients with lumbar spondylosis, 15 with lumbar degenerative spondylolisthesis, 4 with spondylolytic spondylolisthesis, 3 with compression fracture, 3 with pulurent spondylitis, 2 with spondylous osteoporosis, and 1 with spinal osteodesmosis. 99m Tc-HMDP (740 MBq) was intravenously injected and regular SPECT was performed at 3 hours. Gamma camera was performed for about 10 seconds with 5deg intervals, and 36 steps (180deg) of collection was completed after about 6 minutes. The radioisotope accumulation, the presence or absence of sthenia, and its site were evaluated. Forty-seven (88.7%) patients showed excessive accumulation, i.e., 40 (75.5%) in peripheral vertebral osteophyte, 31 (58.5%) in vertebral articulations, and 10 (18.9%) in whole vertebral body. Significantly increased bilateral excessive accumulation was admitted in the vertebral articulations of sliding disc in degenerative spondylolisthesis. SPECT is considered useful in understanding the pathophysiology of degenerative lumber diseases. (S.Y.)

  18. Investigating the effect and photon scattering correction in isotopic scanning with gamma and SPECT

    International Nuclear Information System (INIS)

    Movafeghi, Amir

    1997-01-01

    Nowdays medical imaging systems has been become a very important tool in medicine, both in diagnosis and treatment. With the fast improvement in the computer sciences in the last three decades, three dimensional imaging systems or topographic systems has been developed for the daily applications. Among the different methods, for now X-ray Computerized tomography scanning, Magnetic Resonance Imaging, Single Photon Emission Computerized Tomography and Positron Emission tomography have been found many clinical application. SPECT and PET imaging systems are working with the use of emitting photons from special radioisotopes. In these two systems, image is reconstructed from a distribution of radioisotope in the human body's organs. In SPECT accuracy of data quantification for image reconstruction has influenced from photon attenuation, photon scattering, statistical noises and variation in detector response due to distance. Except scattering other three factors could be modeled and compensated with relatively simple models. Photon scattering is a complex process and usually semiemperical methods is used for its modeling. The effect of scattering photons on images was considered. This survey was done in both lab and clinical cases. Radioisotopes were 192 Ir and 99m Tc. 192 Ir is a solid source with the half-life of 73 days and is used at industrial radiography application. At the beginning, models and methods, were established by the help of 192 Ir. Then at the final stage, they were developed to use for 99m Tc. There are different methods for the error correction of scattered photons. A method from the 'window subtraction' group has been developed for lab cases. Generally, in this method with the use of adjacent window of the photopeak window, scattered photons are subtracted from the original count. A Monte Carlo simulation is used for better evaluation of results. In the clinical section , a dual head SPECT system was (ADAC system of Shariati hospital at Tehran). The

  19. Integration of gamma cameras and PET devices of multiple vendors in several locations

    International Nuclear Information System (INIS)

    Dresel, S.; Vollmar, C.; Sengupta, S.; Hahn, K.

    2002-01-01

    Full text: The Department of Nuclear Medicine of the University of Munich consists of four independently operated locations with a total of 18 gamma cameras (of three vendors), one PET scanner and one coincidence gamma camera. Recent hardware improvements, the installation and development of fast networks and new technologies for storage of large data volumes all contribute to the propagation of digital reading and reporting of nuclear medicine studies. Thus, the vision of a fully digitized nuclear medicine department becomes reality. In 1997 the department started with a strategy to fully integrate the entire number of imaging devices into one network for filmless reading, archiving and distributing nuclear medicine studies throughout the hospitals. The decision was made to use HERMES workstations (Nuclear Diagnostics, Sweden) to connect all primary imaging modalities. The purpose of the workstations located in the Nuclear Medicine departments is threefold: postprocessing, reading and archiving of all data. The workstations are networked throughout the different hospitals and are able to read the proprietary or DICOM data of the vendors of the gamma camera and PET equipment. The HERMES system is connected via DICOM interface to a long term storage device (AGFA, Germany). Additionally a JAVA (SUN Microsystems, USA) based software (JARVIS, Nuclear Diagnostics) is available to view all data from any computer using a web browser. Furthermore all data is linked to the hospital information system and selected imaging data are distributed throughout the hospitals. After commencement of full service of the network in 2000 the department is over 95 % filmfree. The high costs of purchasing hardware- and software-components are compensated for by saving costs of films and by the improvement of the work flow. Independently from these issues, filmless reporting proves to be advantageous over conventional film reading in many facts that justify to switch to a digital department

  20. Progress towards a semiconductor Compton camera for prompt gamma imaging during proton beam therapy for range and dose verification

    Science.gov (United States)

    Gutierrez, A.; Baker, C.; Boston, H.; Chung, S.; Judson, D. S.; Kacperek, A.; Le Crom, B.; Moss, R.; Royle, G.; Speller, R.; Boston, A. J.

    2018-01-01

    The main objective of this work is to test a new semiconductor Compton camera for prompt gamma imaging. Our device is composed of three active layers: a Si(Li) detector as a scatterer and two high purity Germanium detectors as absorbers of high-energy gamma rays. We performed Monte Carlo simulations using the Geant4 toolkit to characterise the expected gamma field during proton beam therapy and have made experimental measurements of the gamma spectrum with a 60 MeV passive scattering beam irradiating a phantom. In this proceeding, we describe the status of the Compton camera and present the first preliminary measurements with radioactive sources and their corresponding reconstructed images.

  1. First demonstration of real-time gamma imaging by using a handheld Compton camera for particle therapy

    Energy Technology Data Exchange (ETDEWEB)

    Taya, T., E-mail: taka48138@ruri.waseda.jp [Research Institute for Science and Engineering, Waseda University, 3-4-1 Okubo, Shinjuku, Tokyo 169-8555 (Japan); Kataoka, J.; Kishimoto, A.; Iwamoto, Y.; Koide, A. [Research Institute for Science and Engineering, Waseda University, 3-4-1 Okubo, Shinjuku, Tokyo 169-8555 (Japan); Nishio, T. [Graduate School of Biomedical and Health Science, Hiroshima University, 1-2-3, Kasumi, Minami-ku, Hiroshima-shi, Hiroshima (Japan); Kabuki, S. [School of Medicine, Tokai University, 143 Shimokasuya, Isehara-shi, Kanagawa (Japan); Inaniwa, T. [National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku, Chiba-shi, Chiba (Japan)

    2016-09-21

    The use of real-time gamma imaging for cancer treatment in particle therapy is expected to improve the accuracy of the treatment beam delivery. In this study, we demonstrated the imaging of gamma rays generated by the nuclear interactions during proton irradiation, using a handheld Compton camera (14 cm×15 cm×16 cm, 2.5 kg) based on scintillation detectors. The angular resolution of this Compton camera is ∼8° at full width at half maximum (FWHM) for a {sup 137}Cs source. We measured the energy spectra of the gamma rays using a LaBr{sub 3}(Ce) scintillator and photomultiplier tube, and using the handheld Compton camera, performed image reconstruction when using a 70 MeV proton beam to irradiate a water, Ca(OH){sub 2}, and polymethyl methacrylate (PMMA) phantom. In the energy spectra of all three phantoms, we found an obvious peak at 511 keV, which was derived from annihilation gamma rays, and in the energy spectrum of the PMMA phantom, we found another peak at 718 keV, which contains some of the prompt gamma rays produced from {sup 10}B. Therefore, we evaluated the peak positions of the projection from the reconstructed images of the PMMA phantom. The differences between the peak positions and the Bragg peak position calculated using simulation are 7 mm±2 mm and 3 mm±8 mm, respectively. Although we could quickly acquire online gamma imaging of both of the energy ranges during proton irradiation, we cannot arrive at a clear conclusion that prompt gamma rays sufficiently trace the Bragg peak from these results because of the uncertainty given by the spatial resolution of the Compton camera. We will develop a high-resolution Compton camera in the near future for further study. - Highlights: • Gamma imaging during proton irradiation by a handheld Compton camera is demonstrated. • We were able to acquire the online gamma-ray images quickly. • We are developing a high resolution Compton camera for range verification.

  2. Test of Compton camera components for prompt gamma imaging at the ELBE bremsstrahlung beam

    Science.gov (United States)

    Hueso-González, F.; Golnik, C.; Berthel, M.; Dreyer, A.; Enghardt, W.; Fiedler, F.; Heidel, K.; Kormoll, T.; Rohling, H.; Schöne, S.; Schwengner, R.; Wagner, A.; Pausch, G.

    2014-05-01

    In the context of ion beam therapy, particle range verification is a major challenge for the quality assurance of the treatment. One approach is the measurement of the prompt gamma rays resulting from the tissue irradiation. A Compton camera based on several position sensitive gamma ray detectors, together with an imaging algorithm, is expected to reconstruct the prompt gamma ray emission density map, which is correlated with the dose distribution. At OncoRay and Helmholtz-Zentrum Dresden-Rossendorf (HZDR), a Compton camera setup is being developed consisting of two scatter planes: two CdZnTe (CZT) cross strip detectors, and an absorber consisting of one Lu2SiO5 (LSO) block detector. The data acquisition is based on VME electronics and handled by software developed on the ROOT framework. The setup has been tested at the linear electron accelerator ELBE at HZDR, which is used in this experiment to produce bunched bremsstrahlung photons with up to 12.5 MeV energy and a repetition rate of 13 MHz. Their spectrum has similarities with the shape expected from prompt gamma rays in the clinical environment, and the flux is also bunched with the accelerator frequency. The charge sharing effect of the CZT detector is studied qualitatively for different energy ranges. The LSO detector pixel discrimination resolution is analyzed and it shows a trend to improve for high energy depositions. The time correlation between the pulsed prompt photons and the measured detector signals, to be used for background suppression, exhibits a time resolution of 3 ns FWHM for the CZT detector and of 2 ns for the LSO detector. A time walk correction and pixel-wise calibration is applied for the LSO detector, whose resolution improves up to 630 ps. In conclusion, the detector setup is suitable for time-resolved background suppression in pulsed clinical particle accelerators. Ongoing tasks are the quantitative comparison with simulations and the test of imaging algorithms. Experiments at proton

  3. Test of Compton camera components for prompt gamma imaging at the ELBE bremsstrahlung beam

    International Nuclear Information System (INIS)

    Hueso-González, F; Golnik, C; Berthel, M; Dreyer, A; Enghardt, W; Kormoll, T; Rohling, H; Pausch, G; Fiedler, F; Heidel, K; Schöne, S; Schwengner, R; Wagner, A

    2014-01-01

    In the context of ion beam therapy, particle range verification is a major challenge for the quality assurance of the treatment. One approach is the measurement of the prompt gamma rays resulting from the tissue irradiation. A Compton camera based on several position sensitive gamma ray detectors, together with an imaging algorithm, is expected to reconstruct the prompt gamma ray emission density map, which is correlated with the dose distribution. At OncoRay and Helmholtz-Zentrum Dresden-Rossendorf (HZDR), a Compton camera setup is being developed consisting of two scatter planes: two CdZnTe (CZT) cross strip detectors, and an absorber consisting of one Lu 2 SiO 5 (LSO) block detector. The data acquisition is based on VME electronics and handled by software developed on the ROOT framework. The setup has been tested at the linear electron accelerator ELBE at HZDR, which is used in this experiment to produce bunched bremsstrahlung photons with up to 12.5 MeV energy and a repetition rate of 13 MHz. Their spectrum has similarities with the shape expected from prompt gamma rays in the clinical environment, and the flux is also bunched with the accelerator frequency. The charge sharing effect of the CZT detector is studied qualitatively for different energy ranges. The LSO detector pixel discrimination resolution is analyzed and it shows a trend to improve for high energy depositions. The time correlation between the pulsed prompt photons and the measured detector signals, to be used for background suppression, exhibits a time resolution of 3 ns FWHM for the CZT detector and of 2 ns for the LSO detector. A time walk correction and pixel-wise calibration is applied for the LSO detector, whose resolution improves up to 630 ps. In conclusion, the detector setup is suitable for time-resolved background suppression in pulsed clinical particle accelerators. Ongoing tasks are the quantitative comparison with simulations and the test of imaging algorithms. Experiments at proton

  4. {sup 67}Ga-SPECT/CT with a hybrid system in the clinical management of lymphoma

    Energy Technology Data Exchange (ETDEWEB)

    Palumbo, Barbara; Sivolella, Silvio; Palumbo, Renato [University of Perugia, Nuclear Medicine Section, Department of Radiological Sciences, Perugia (Italy); Palumbo, Isabella; Liberati, Anna Marina [University of Perugia, Internal Medicine and Oncology, Department of Clinical and Experimental Medicine, Perugia (Italy)

    2005-09-01

    The purpose of this study was to investigate the added value of co-registered fusion imaging using a hybrid system in patients with lymphoma. Twenty-four lymphoma patients underwent {sup 67}Ga-SPECT/CT using a hybrid tomograph consisting of a dual-head, variable-angle gamma camera and a low-dose X-ray tube. Results were compared with those of SPECT alone. Forty-five lesions were identified by SPECT alone, while 49 were detected by SPECT/CT. Forty out of the 45 lesions observed on SPECT were confirmed as lymphoma, but five were due to other causes (thoracic aorta blood pool activity, sialoadenitis in the submandibular gland, bowel activity, rib fracture and bone marrow activation due to radiotherapy). SPECT/CT identified nine more neoplastic lesions compared with SPECT alone: four areas of radiopharmaceutical accumulation were observed in para-aortic lymph nodes, three in the spleen, one in the liver and one in para-iliac lymph nodes. In five cases, SPECT/CT provided additional anatomical information over SPECT alone. In four patients, four large areas of {sup 67}Ga uptake (one mediastinal, two supraclavicular and one para-aortic) were better characterised; in one subject uptake was localised in the seventh thoracic vertebra only by SPECT/CT. Hybrid imaging provided additional data in 13 patients (54.2%), thus inducing oncologists to reconsider the therapeutic approach in eight subjects (33.2%): unnecessary treatment was avoided in four (16.6%) while therapy was altered in another four (16.6%). SPECT/CT hybrid system is able to provide information not obtained by SPECT alone. It allows the anatomical localisation of lymphoma and physiological radiopharmaceutical uptake, facilitates the diagnosis of tumours located in the abdomen (subdiaphragmatic lesions) and provides information that may cause a change in therapeutic strategy. (orig.)

  5. Diagnostic performance of a novel cadmium-zinc-telluride gamma camera system assessed using fractional flow reserve.

    Science.gov (United States)

    Tanaka, Hirokazu; Chikamori, Taishiro; Tanaka, Nobuhiro; Hida, Satoshi; Igarashi, Yuko; Yamashita, Jun; Ogawa, Masashi; Shiba, Chie; Usui, Yasuhiro; Yamashina, Akira

    2014-01-01

    Although the novel cadmium-zinc-telluride (CZT) camera system provides excellent image quality, its diagnostic value using thallium-201 as assessed on coronary angiography (CAG) and fractional flow reserve (FFR) has not been validated. METHODS AND RESULTS: To evaluate the diagnostic accuracy of the CZT ultrafast camera system (Discovery NM 530c), 95 patients underwent stress thallium-201 single-photon emission computed tomography (SPECT) and then CAG within 3 months. Image acquisition was performed in the supine and prone positions after stress for 5 and 3 min, respectively, and in the supine position at rest for 10 min. Significant stenosis was defined as ≥90% diameter narrowing on visual estimation, or a lesion with <90% and ≥50% stenosis and FFR ≤0.75. To detect individual coronary stenosis, the respective sensitivity, specificity, and accuracy were 90%, 64%, and 78% for left anterior descending coronary artery stenosis, 78%, 84%, and 81% for left circumflex stenosis, and 83%, 47%, and 60% for right coronary artery (RCA) stenosis. The combination of prone and supine imaging had a higher specificity for RCA disease than supine imaging alone (65% vs. 47%), with an improvement in accuracy from 60% to 72%. Using thallium-201 with short acquisition time, combined with prone imaging, CZT SPECT had a high diagnostic yield in detecting significant coronary stenosis as assessed using FFR.

  6. The Advanced Gamma-ray Imaging System (AGIS): Camera Electronics Designs

    Science.gov (United States)

    Tajima, H.; Buckley, J.; Byrum, K.; Drake, G.; Falcone, A.; Funk, S.; Holder, J.; Horan, D.; Krawczynski, H.; Ong, R.; Swordy, S.; Wagner, R.; Williams, D.

    2008-04-01

    AGIS, a next generation of atmospheric Cherenkov telescope arrays, aims to achieve a sensitivity level of a milliCrab for gamma-ray observations in the energy band of 40 GeV to 100 TeV. Such improvement requires cost reduction of individual components with high reliability in order to equip the order of 100 telescopes necessary to achieve the sensitivity goal. We are exploring several design concepts to reduce the cost of camera electronics while improving their performance. These design concepts include systems based on multi-channel waveform sampling ASIC optimized for AGIS, a system based on IIT (image intensifier tube) for large channel (order of 1 million channels) readout as well as a multiplexed FADC system based on the current VERITAS readout design. Here we present trade-off in the studies of these design concepts.

  7. Renal scintiscanning: Methodology and normal findings using 131I hippurane and a gamma camera

    International Nuclear Information System (INIS)

    Ruppik, G.

    1982-01-01

    The methodological and mathematical fundamentals of renal functional scintiscanning using a gamma camera and 131 I-hippurane are described for ING, whole-body clearance, plasma clearance, and unilateral clearance. Methods are compared introducing the Tuebingen method of unilateral clearance with tolerance limits. The data of the patients are presented as standard values with a limit of two standard deviations for whole-body clearance unilateral clearance, the parenchymal phase and the excretion phase including a percentage of excretion. Comparative studies are presented for the main parameters of clearance and unilateral clearance, and the data obtained are documented in tables and graphs together with the initial data and the standard values. The results and problems of the method are gone into. (orig./MG) [de

  8. Risks assessment associated with the use of an analyzer for gamma cameras diagnostic

    International Nuclear Information System (INIS)

    Oramas Polo, I.; Figueroa del Valle, D. G.

    2013-01-01

    Technological development experienced by the industrialized countries has been accompanied by a significant improvement in living standards. Likewise, the proliferation of facilities and transportation of certain materials have involved the emergence of new risks, which could cause accidents with a strong impact on people and the environment. The paper makes a risk assessment associated with the use of an analyzer for Gamma Cameras diagnostic. The method is bases on determining the number of risks HRN (Hazard Rating Number). As a result of the methodology used was obtained the risks that have more implications in the use of this system and sets safety rules for their use and an action plan for managing them. (Author)

  9. Single-acquisition method for simultaneous determination of extrinsic gamma-camera sensitivity and spatial resolution

    Energy Technology Data Exchange (ETDEWEB)

    Santos, J.A.M. [Servico de Fisica Medica, Instituto Portugues de Oncologia Francisco Gentil do Porto, E.P.E., Rua Dr. Antonio Bernardino de Almeida, 4200-072 Porto (Portugal)], E-mail: a.miranda@portugalmail.pt; Sarmento, S. [Servico de Fisica Medica, Instituto Portugues de Oncologia Francisco Gentil do Porto, E.P.E., Rua Dr. Antonio Bernardino de Almeida, 4200-072 Porto (Portugal); Alves, P.; Torres, M.C. [Departamento de Fisica da Universidade do Porto, Rua do Campo Alegre 687, 4169-007 Porto (Portugal); Bastos, A.L. [Servico de Medicina Nuclear, Instituto Portugues de Oncologia Francisco Gentil do Porto, E.P.E., Rua Dr. Antonio Bernardino de Almeida, 4200-072 Porto (Portugal); Ponte, F. [Servico de Fisica Medica, Instituto Portugues de Oncologia Francisco Gentil do Porto, E.P.E., Rua Dr. Antonio Bernardino de Almeida, 4200-072 Porto (Portugal)

    2008-01-15

    A new method for measuring simultaneously both the extrinsic sensitivity and spatial resolution of a gamma-camera in a single planar acquisition was implemented. A dual-purpose phantom (SR phantom; sensitivity/resolution) was developed, tested and the results compared with other conventional methods used for separate determination of these two important image quality parameters. The SR phantom yielded reproducible and accurate results, allowing an immediate visual inspection of the spatial resolution as well as the quantitative determination of the contrast for six different spatial frequencies. It also proved to be useful in the estimation of the modulation transfer function (MTF) of the image formation collimator/detector system at six different frequencies and can be used to estimate the spatial resolution as function of the direction relative to the digital matrix of the detector.

  10. Single-acquisition method for simultaneous determination of extrinsic gamma-camera sensitivity and spatial resolution

    International Nuclear Information System (INIS)

    Santos, J.A.M.; Sarmento, S.; Alves, P.; Torres, M.C.; Bastos, A.L.; Ponte, F.

    2008-01-01

    A new method for measuring simultaneously both the extrinsic sensitivity and spatial resolution of a gamma-camera in a single planar acquisition was implemented. A dual-purpose phantom (SR phantom; sensitivity/resolution) was developed, tested and the results compared with other conventional methods used for separate determination of these two important image quality parameters. The SR phantom yielded reproducible and accurate results, allowing an immediate visual inspection of the spatial resolution as well as the quantitative determination of the contrast for six different spatial frequencies. It also proved to be useful in the estimation of the modulation transfer function (MTF) of the image formation collimator/detector system at six different frequencies and can be used to estimate the spatial resolution as function of the direction relative to the digital matrix of the detector

  11. Risk analysis for working with an analyzer for gamma cameras diagnostic

    International Nuclear Information System (INIS)

    Oramas Polo, Ivon; Figueroa del Valle, Diana G.

    2014-01-01

    In this work, an analysis of the risks for working with an analyzer for gamma cameras diagnostic was made. The method employed is based on determining the Hazard Rating Number (HRN). The results showed that the risks with higher value of HRN are electrocution with 100 and touch source container with hands with 75. These risks were classified as 'Very High' and 'High' respectively. The following risks were classified as 'Important': Fall of the source container (HRN = 25), high dose of the sample in the container (HRN = 20) and fracture of glass detector (HRN = 30). The wrong shielding of the source container (HRN = 10) is a risk that was classified as L ow . Safety rules for use of the system are indicated. An action plan for risk management is also presented. (author)

  12. A new approach to the evaluation of peripheral vascular disease using the gamma camera

    International Nuclear Information System (INIS)

    Gerritsen, H.A.M.

    1976-01-01

    To estimate the degree of impaired perfusion in legs, and the extent of improvement after treatment, a functional test was developed using a gamma camera to follow the perfusion of intravenously injected sup(99m)Tc-pertechnetate. An analysis is given of normal and pathologic curve patterns. The influence of the severity of occlusive arterial disease on the arrival and distribution of radioactivity in the leg is demonstrated. After vascular surgery, changes in the curve pattern and the imaging of activity distribution reflected the function of the inserted bypass grafts. The test proved to be useful in the differentiation between patients with false claudication complaints due to non-arterial disease and patients with true claudication. It is concluded that the technique presented in this thesis can serve as a useful, non-invasive, screening test prior to arteriography and as a functional assessment of vascular reconstruction

  13. Measurement of spleen size using gamma camera scintigraphy in essential thrombocythaemia

    Energy Technology Data Exchange (ETDEWEB)

    Revesz, P. (Department of Medicine, Oestra Hospital, University of Goeteborg, Goeteborg (Sweden)); Carneskog, J.; Wadenvik, H.; Kutti, J. (Haematology Section, Department of Medicine, Sahlgrenska Hospital, University of Goeteborg, Goeteborg (Sweden)); Jarneborn, L. (Department of Clinical Physiology, Oestra Hospital, University of Goeteborg, Goeteborg (Sweden))

    1993-09-01

    By using gamma camera imaging the spleen size was determined in 33 consecutive patients with essential thrombocythaemia (ET) and in 33 consecutive patients with reactive thrombocytosis (RT). All ET patients were newly diagnosed and had not received myelosuppressive treatment prior to study; they all fulfilled the criteria for ET as established by the Polycythemia Vera Study Group. In both posterior and lateral projections, the spleen area in the group of ET patients was significantly larger than in the RT patients. The present study has shown that 39% of ET patients at diagnosis have splenic enlargement. Evaluation of Spleen size is therefore a useful diagnostic test in patients presenting with unexplained thrombocytosis. (au) (15 refs.).

  14. PET with coincidence gamma cameras - clinical benefit from the radiooncologists' point of view

    International Nuclear Information System (INIS)

    Richter, E.; Feyerabend, T.; Stallmann, C.; Lauer, I.; Baehre, M.

    2001-01-01

    Positron emission tomography with FDG (FDG-PET) is a new technique, which displays the cellular metabolic activity. Since tumors exhibit an increased metabolic activity when compared to normal tissue, this imaging modality has a particularly high importance. FDG-PET is not only useful for localizing and staging of malignant tumors, but also to evaluate therapy response. In this context, PET is superior to morphologically orientated modalities, because therapeutically induced changes in glucose metabolism precede morphologic alterations. Numerous studies indicate, that PET will play an important role in radiooncology concerning therapy planning and monitoring the effects of therapy during and after treatment. Further clinical studies are necessary to evaluate the information provided by FDG-PET more precisely. Coincidence gamma cameras with adequate imaging characteristics will gain enhanced importance to meet these increasing demands. (orig.) [de

  15. Gastric emptying time in normal subjects using /sup 51/Cr and a gamma camera

    Energy Technology Data Exchange (ETDEWEB)

    Claure, H [Hospital del Salvador, Santiago de Chile; Calderon, C; Braunschweig, T; Diaz, G

    1974-12-01

    Gastric emptying time of a meal consisting of 2 eggs, 50 g of white bread, and 300 ml of milk, was measured in 10 normal subjects, 5 males and 5 females, with an average age of 34.7 years. 200 uCi of Cr-51 were added to the meal and external counting was performed using a ..gamma.. camera. The rate of gastric emptying was estimated by the decrease in radiation counts over the gastric area. In 68.6 percent of the subjects the mean gastric emptying time was 60 min. The average curve showed a complex exponential slope with 2 distinct phases: a fast one between 0 and 35 min and a slow one between 40 and 60 min. These results suggest that a normal gastric emptying time consists of 2 different rate phases when a meal of mixed consistency (liquid and solid) is ingested.

  16. Applications of multi-pinhole gamma camera collimation to tomography and image enhancement

    Science.gov (United States)

    Simpson, D. R.

    1981-06-01

    Multi-pinhole gamma camera collimation was introduced in the field of emission tomography. This collimation process simultaneously produces several images covering a limited angular range, which may then be recombined to obtain tomographic slices of the object imaged. A possible method for improving the images obtained by this technique by combining two multi-pinhole views taken 90 deg apart was investigated. Collimators were designed and built both for tomography and imaging tablet disintegration, and computer programs were written to reconstruct the images by simple backprojection and by filtered backprojection. The use of multi-pinhole collimators to image the disintegration of tablets in vivo was clearly demonstrated. Phantom tests done in vitro were capable of imaging defects as small as 5 sq mm, while images made with real tablets both in vitro and in vivo readily showed the onset and progress of the tablet disintegration.

  17. A study of quantitative scale display of the organ uptake with gamma-camera

    Energy Technology Data Exchange (ETDEWEB)

    Ishigami, K; Matsumoto, M [Kumamoto Univ. (Japan) School of Medicine

    1975-05-01

    The fundamental study of quantitative scale display of the organ uptake with ..gamma..-camera was performed in special respect of the thyroid gland and the pancreas. As one of the measurements on certain dimension of the organ, an optical progression outside the digital image was expressed, and was subjected to the quantitative scale with the use of the threshold level. And a rather satisfactory correlation was clinically obtained between the scale display and the thyroidal /sup 131/I uptake. For the purpose of revising the above scale display, the organ depth was measured with RI by the aid of the phantom. Then the pancreas depth determined by the count rate ratio curve of 140 and 270 keV peak of /sup 75/Se energies. However, the body background and the radioactive rays from the neighboring organs interfered with this curve.

  18. FDG scan on an ordinary coincidence gamma camera (CDET) -preliminary data in pulmonary or colorectal cancer

    Energy Technology Data Exchange (ETDEWEB)

    Montravers, F.; Grahek, D.; Ghazzar, N.; Younsi, N.; Kerrou, K.; Talbot, J.N. [Hopital Tenon, 75 - Paris (France). Services de Medecine Nucleaire; Wartski, M.; Zerbib, E. [Hopital Marie Lannelongue Le Plessis Robinson (France); Lumbroso, J. [Institut Gustave Roussy Villejuif (France)

    1997-12-31

    Full text. The purpose of this study to evaluate the impact of FDG scan performed on an ordinary CDET gamma camera on the therapeutic management of patients with pulmonary nodules or with suspicion of recurrent colorectal carcinoma. Methods: two tomoscintigrams (thorax and abdomen) were acquired, using a PICKER Prism XP 2000 coincidence gamma camera, 45 m after i.v. injection of 100-150 MBq of {sup 18} F-FDG in fasting patients. The 21 pts were explored in July or August 1997. Preliminary results: among 12 patients with pulmonary nodules, the planed surgery was replaced by chemotherapy after visualization of unknown metastases accumulating FDG in 3 patients. In another one, the high uptake of FDG by a lung nodule which has been known for 6 years, led to surgery and objectivation of an adenocarcinoma. In one case, the absence of FDG uptake corresponded to an abscess (true negative result). In the other 7 patients, the indication of surgery was confirmed but the procedure was modified in 2 cases. In case of suspicion of recurrent colorectal carcinoma (9 patients), the finding of a single focus of FDG uptake whereas CT scan was negative or inconclusive let do the decision of surgery in 3 patients. In one patient with pelvic pain without increase of tumor markers levels and with normal CT scan, a normal FDG scan confirmed the physician`s hypothesis of pain due to the previous therapy but do not recurrence. In one patient, the finding of 3 foci of uptake of FDG whereas CT scan was inconclusive confirmed the indication of chemotherapy. In 2 patients with FDG abdominal foci without morphologic abnormalities, the therapeutic strategy is not yet decided in 2 patients, no foci could be found. In conclusion, these preliminary results show that FDG scan has provided a help to the physician indecision-making for therapeutic strategy in 8 patients on 21 (38%) and a help to the surgeon in 2 more cases (48% as a whole)

  19. FDG scan on an ordinary coincidence gamma camera (CDET) -preliminary data in pulmonary or colorectal cancer

    International Nuclear Information System (INIS)

    Montravers, F.; Grahek, D.; Ghazzar, N.; Younsi, N.; Kerrou, K.; Talbot, J.N.; Lumbroso, J.

    1997-01-01

    Full text. The purpose of this study to evaluate the impact of FDG scan performed on an ordinary CDET gamma camera on the therapeutic management of patients with pulmonary nodules or with suspicion of recurrent colorectal carcinoma. Methods: two tomoscintigrams (thorax and abdomen) were acquired, using a PICKER Prism XP 2000 coincidence gamma camera, 45 m after i.v. injection of 100-150 MBq of 18 F-FDG in fasting patients. The 21 pts were explored in July or August 1997. Preliminary results: among 12 patients with pulmonary nodules, the planed surgery was replaced by chemotherapy after visualization of unknown metastases accumulating FDG in 3 patients. In another one, the high uptake of FDG by a lung nodule which has been known for 6 years, led to surgery and objectivation of an adenocarcinoma. In one case, the absence of FDG uptake corresponded to an abscess (true negative result). In the other 7 patients, the indication of surgery was confirmed but the procedure was modified in 2 cases. In case of suspicion of recurrent colorectal carcinoma (9 patients), the finding of a single focus of FDG uptake whereas CT scan was negative or inconclusive let do the decision of surgery in 3 patients. In one patient with pelvic pain without increase of tumor markers levels and with normal CT scan, a normal FDG scan confirmed the physician's hypothesis of pain due to the previous therapy but do not recurrence. In one patient, the finding of 3 foci of uptake of FDG whereas CT scan was inconclusive confirmed the indication of chemotherapy. In 2 patients with FDG abdominal foci without morphologic abnormalities, the therapeutic strategy is not yet decided in 2 patients, no foci could be found. In conclusion, these preliminary results show that FDG scan has provided a help to the physician indecision-making for therapeutic strategy in 8 patients on 21 (38%) and a help to the surgeon in 2 more cases (48% as a whole)

  20. Heart imaging by cadmium telluride gamma camera European Program 'BIOMED' consortium

    CERN Document Server

    Scheiber, C; Chambron, J; Prat, V; Kazandjan, A; Jahnke, A; Matz, R; Thomas, S; Warren, S; Hage-Hali, M; Regal, R; Siffert, P; Karman, M

    1999-01-01

    Cadmium telluride semiconductor detectors (CdTe) operating at room temperature are attractive for medical imaging because of their good energy resolution providing excellent spatial and contrast resolution. The compactness of the detection system allows the building of small light camera heads which can be used for bedside imaging. A mobile pixellated gamma camera based on 2304 CdTe (pixel size: 3x3 mm, field of view: 15 cmx15 cm) has been designed for cardiac imaging. A dedicated 16-channel integrated circuit has also been designed. The acquisition hardware is fully programmable (DSP card, personal computer-based system). Analytical calculations have shown that a commercial parallel hole collimator will fit the efficiency/resolution requirements for cardiac applications. Monte-Carlo simulations predict that the Moire effect can be reduced by a 15 deg. tilt of the collimator with respect to the detector grid. A 16x16 CdTe module has been built for the preliminary physical tests. The energy resolution was 6.16...

  1. Gabor zone-plate apertures for imaging with the mercuric iodide gamma-ray camera

    Energy Technology Data Exchange (ETDEWEB)

    Patt, B E [EG and G Energy Measurements, Inc., Goleta, CA (USA); Meyyappan, A; Cai, A; Wade, G [California Univ., Santa Barbara (USA). Dept. of Electrical and Computer Engineering

    1990-12-20

    Gabor zone-plate (GZP) apertures have been developed for use in EG and G EM's mercuric iodide (HgI{sub 2}) gamma-ray camera. The purpose of such an aperture is to increase efficiency, while maintaining good resolution. The GZP is similar to the Fresnel zone plate (FZP) but it has continuous transitions between opaque and transparent regions. Because there are no sharp transitions in the transmission, the inherent interference noise in GZP imaging is lower than that in FZP imaging. GZP parameters were chosen by considering the effects of constraints such as detector pixel size, number of pixels, minimum field of view required, maximum angle of incidence tolerated, and the Nyquist criterion for the minimum sampling rate. As a result an aperture was designed and fabricated with eight zones and a diameter of 3 cm. Lead was chosen as the aperture medium due to its high attenuation coefficient. Experimental data were obtained from the camera with the above GZP aperture. The point-spread function was determined and compared to the calculated response. Excellent agreement was obtained. The reconstruction process involves simulating, by computer, planar-wave illumination of a scaled transparency of the image and recording the intensity pattern at the focal plane. (orig.).

  2. Technetium-99m-labelled red blood cell imaging in the diagnosis of hepatic haemangiomas: the role of SPECT/CT with a hybrid camera

    Energy Technology Data Exchange (ETDEWEB)

    Schillaci, Orazio; Danieli, Roberta; Manni, Carlo; Capoccetti, Francesca; Simonetti, Giovanni [Department of Biopathology and Diagnostic Imaging, University ' ' Tor Vergata' ' , Rome (Italy)

    2004-07-01

    Delayed liver single-photon emission computed tomography (SPECT) after {sup 99m}Tc red blood cell (RBC) labelling is helpful in detecting hepatic haemangiomas; however, diagnosis can be difficult when lesions are situated adjacent to structures like the inferior vena cava, the heart or hepatic vessels, where blood activity persists. The aims of this study were to evaluate the usefulness of RBC SPECT and transmission computed tomography (RBC SPECT/CT) performed simultaneously with a hybrid imaging system for correct characterisation of hepatic lesions in patients with suspected haemangioma, and to assess the additional value of fused images compared with SPECT alone. Twelve patients with 24 liver lesions were studied. The acquisitions of both anatomical (CT) and functional (SPECT) data were performed during a single session. SPECT images were first interpreted alone and then re-evaluated after adding the transmission anatomical maps. Image fusion was successful in all patients, with perfect correspondence between SPECT and CT data, allowing the precise anatomical localisation of sites of increased blood pool activity. SPECT/CT had a significant impact on results in four patients (33.3%) with four lesions defined as indeterminate on SPECT images, accurately characterising the hot spot foci located near vascular structures. In conclusion, RBC SPECT/CT imaging using this hybrid SPECT/CT system is feasible and useful in the identification or exclusion of suspected hepatic haemangiomas located near regions with high vascular activity. (orig.)

  3. A basic component for ISGRI, the CdTe gamma camera on board the INTEGRAL satellite

    International Nuclear Information System (INIS)

    Arques, M.; Baffert, N.; Lattard, D.

    1999-01-01

    A basic component, called Polycell, has been developed for the ISGRI (INTEGRAL Soft Gamma Ray Imager) CdTe camera on board the INTEGRAL (INTErnational Gamma-Ray Astrophysics Laboratory) satellite. Operating at room temperature, it covers the 20 keV--1 MeV energy range. It features a sub-ensemble of 16 CdTe detectors and their associated front end electronics. This electronics is based on 4-channel analog-digital ASICs. Their analog part features a low noise preamplifier, allowing a threshold below 20 keV and a pulse rise-time measurement which permits a charge loss correction. The digital part ensures the internal acquisition timing sequence as well as the dialogue with external electronics. Two versions of the ISGRI ASIC have been developed in a collaboration of two CEA microelectronics teams from CEA/DTA/LETI/DSYS and CEA/DSM/DAPNIA/SEI, respectively on a standard CMOS AMS process hardened against radiation by lay-out, and on a Silicon On Insulator process (DMILL MHS), the latter being latch-up free. This paper presents the ASIC and polycell architecture as well as experimental results obtained with polycells equipped with AMS ASICs

  4. Realization and study of spectral properties of the ISGRI gamma-ray camera

    International Nuclear Information System (INIS)

    Limousin, O.

    2001-11-01

    This work evaluates spectroscopic and physical properties of CdTe detectors in view of assembling a large number on a new generation spectro-imager for space gamma-ray astronomy. Study, optimization, realization and calibration of modular detection units of the ISGRI camera are described. After a description of the experimental context of the INTEGRAL program and a review of the physical processes involved in gamma-ray photon detectors, we present an analysis of the properties of CdTe detectors attempting to be so exhaustive as possible. We propose the base point of a global model, which relates charge transport properties, spectral response and possible instabilities in the detectors. We propose a new formulation of the Hecht relation that describes charge loss as a function of the detector charge transport properties. We discuss at length the method of charge loss correction and its consequences on the associated integrated electronics definition. Finally, we illustrate our instrument capabilities using as an example the observation of titanium 44 lines in historical supernovae. (author)

  5. Nema tests in gamma-cameras. Independent implementation of manufacturer; Pruebas Nema en gammacamaras. Implementacion independiente del fabricante

    Energy Technology Data Exchange (ETDEWEB)

    Ramos Pacho, J. A.; Montes Fuentes, C.; Verde Velasco, J. M.; Perez Alvarez, M. E.; Delgado Aparicio, J. M.; Cons Perez, N.; Gomez Gonzalez, N.; Garcia Repiso, S.; Saez Beltran, M.; Gomez Llorente, P. L.

    2013-07-01

    The analysis of test results of quality control in gamma cameras, as extrinsic planar uniformity and the spatial resolution is often limited by intrinsic equipment tools and procedures. With the objective of an independent assessment of such evidence and better management and monitoring of the data obtained are made two separate programs in Matlab. (Author)

  6. Small Field of View Scintimammography Gamma Camera Integrated to a Stereotactic Core Biopsy Digital X-ray System

    Energy Technology Data Exchange (ETDEWEB)

    Andrew Weisenberger; Fernando Barbosa; T. D. Green; R. Hoefer; Cynthia Keppel; Brian Kross; Stanislaw Majewski; Vladimir Popov; Randolph Wojcik

    2002-10-01

    A small field of view gamma camera has been developed for integration with a commercial stereotactic core biopsy system. The goal is to develop and implement a dual-modality imaging system utilizing scintimammography and digital radiography to evaluate the reliability of scintimammography in predicting the malignancy of suspected breast lesions from conventional X-ray mammography. The scintimammography gamma camera is a custom-built mini gamma camera with an active area of 5.3 cm /spl times/ 5.3 cm and is based on a 2 /spl times/ 2 array of Hamamatsu R7600-C8 position-sensitive photomultiplier tubes. The spatial resolution of the gamma camera at the collimator surface is < 4 mm full-width at half-maximum and a sensitivity of /spl sim/ 4000 Hz/mCi. The system is also capable of acquiring dynamic scintimammographic data to allow for dynamic uptake studies. Sample images of preliminary clinical results are presented to demonstrate the performance of the system.

  7. Statistical pixelwise inference models for planar data analysis: an application to gamma-camera uniformity monitoring

    Energy Technology Data Exchange (ETDEWEB)

    Kalemis, A [Joint Department of Physics, Institute of Cancer Research and Royal Marsden NHS Foundation Trust, Downs Road, Sutton, Surrey SM2 5PT (United Kingdom); Bailey, D L [Department of Nuclear Medicine, Royal North Shore Hospital, St Leonards, NSW 2065 (Australia); Flower, M A [Joint Department of Physics, Institute of Cancer Research and Royal Marsden NHS Foundation Trust, Downs Road, Sutton, Surrey SM2 5PT (United Kingdom); Lord, S K [Joint Department of Physics, Institute of Cancer Research and Royal Marsden NHS Foundation Trust, Downs Road, Sutton, Surrey SM2 5PT (United Kingdom); Ott, R J [Joint Department of Physics, Institute of Cancer Research and Royal Marsden NHS Foundation Trust, Downs Road, Sutton, Surrey SM2 5PT (United Kingdom)

    2004-07-21

    In this paper two tests based on statistical models are presented and used to assess, quantify and provide positional information of the existence of bias and/or variations between planar images acquired at different times but under similar conditions. In the first test a linear regression model is fitted to the data in a pixelwise fashion, using three mathematical operators. In the second test a comparison using z-scoring is used based on the assumption that Poisson statistics are valid. For both tests the underlying assumptions are as simple and few as possible. The results are presented as parametric maps of either the three operators or the z-score. The z-score maps can then be thresholded to show the parts of the images which demonstrate change. Three different thresholding methods (naive, adaptive and multiple) are presented: together they cover almost all the needs for separating the signal from the background in the z-score maps. Where the expected size of the signal is known or can be estimated, a spatial correction technique (referred to as the reef correction) can be applied. These tests were applied to flood images used for the quality control of gamma camera uniformity. Simulated data were used to check the validity of the methods. Real data were acquired from four different cameras from two different institutions using a variety of acquisition parameters. The regression model found the bias in all five simulated cases and it also found patterns of unstable regions in real data where visual inspection of the flood images did not show any problems. In comparison the z-map revealed the differences in the simulated images from as low as 1.8 standard deviations from the mean, corresponding to a differential uniformity of 2.2% over the central field of view. In all cases studied, the reef correction increased significantly the sensitivity of the method and in most cases the specificity as well. The two proposed tests can be used either separately or in

  8. Statistical pixelwise inference models for planar data analysis: an application to gamma-camera uniformity monitoring

    International Nuclear Information System (INIS)

    Kalemis, A; Bailey, D L; Flower, M A; Lord, S K; Ott, R J

    2004-01-01

    In this paper two tests based on statistical models are presented and used to assess, quantify and provide positional information of the existence of bias and/or variations between planar images acquired at different times but under similar conditions. In the first test a linear regression model is fitted to the data in a pixelwise fashion, using three mathematical operators. In the second test a comparison using z-scoring is used based on the assumption that Poisson statistics are valid. For both tests the underlying assumptions are as simple and few as possible. The results are presented as parametric maps of either the three operators or the z-score. The z-score maps can then be thresholded to show the parts of the images which demonstrate change. Three different thresholding methods (naive, adaptive and multiple) are presented: together they cover almost all the needs for separating the signal from the background in the z-score maps. Where the expected size of the signal is known or can be estimated, a spatial correction technique (referred to as the reef correction) can be applied. These tests were applied to flood images used for the quality control of gamma camera uniformity. Simulated data were used to check the validity of the methods. Real data were acquired from four different cameras from two different institutions using a variety of acquisition parameters. The regression model found the bias in all five simulated cases and it also found patterns of unstable regions in real data where visual inspection of the flood images did not show any problems. In comparison the z-map revealed the differences in the simulated images from as low as 1.8 standard deviations from the mean, corresponding to a differential uniformity of 2.2% over the central field of view. In all cases studied, the reef correction increased significantly the sensitivity of the method and in most cases the specificity as well. The two proposed tests can be used either separately or in

  9. Characterizing the detection module paving the ECLAIRs camera for the SVOM gamma-ray buts mission

    International Nuclear Information System (INIS)

    Nasser, Guillaume

    2015-01-01

    Gamma-ray bursts (GRBs) are short and very intense flashes of X-gamma-ray photons lasting from few milliseconds to hundreds of seconds appearing randomly over the sky. These cosmological events are thought to be due to the catastrophic formation of newly formed black holes following the collapse of some massive stars or after the coalescence of two compact objects and resulting in the launch of powerful ultra-relativistic jets orientated towards the Earth. The Sino-French mission SVOM (Space-based multi-band Variable Object Monitor) is dedicated to the study of these extreme and fascinating transient events and expected to be launched in 2020's. The satellite will implement a multi-wavelength science payload amongst which the core will be the large-field coded-mask camera ECLAIRs in charge of the detection and the localisation of GRBs in the 4-150 keV range. The ECLAIRs detection plane, DPIX, is made of 80x80 Schottky CdTe semi-conductor detectors and the front-end electronics. During my PhD, I mainly worked on the characterization of the scientific performance of the elementary detection modules called XRDPIX (i.e. a hybrid made of 8*4 detectors coupled with a low-noise ASIC) that will paved the DPIX. The main goal is then to derive the best suitable choice of the instrumental parameters in order to optimize the camera in-flight performance. In the manuscript, I discuss the methodology I used to explore the instrument parameter space. I describe the various testing protocols that I created and the different tests that I performed using several XRDPIX modules in a thermal-vacuum chamber and irradiated with radioactive sources. I discuss in detail the results and the various observables that I used to define the optimal in-flight operating zone of the detection plane. I also study the contribution of the different noise sources coming from the detectors and the electronic chain with a model I designed in order to control the quality of the hybridization process. I

  10. Problems in the optimum display of SPECT images

    International Nuclear Information System (INIS)

    Fielding, S.L.

    1988-01-01

    The instrumentation, computer hardware and software, and the image display system are all very important in the production of diagnostically useful SPECT images. Acquisition and processing parameters are discussed which can affect the quality of SPECT images. Regular quality control of the gamma camera and computer is important to keep the artifacts due to instrumentation to a minimum. The choice of reconstruction method will depend on the statistics in the study. The paper has shown that for high count rate studies, a high pass filter can be used to enhance the reconstructions. For lower count rate studies, pre-filtering is useful and the data can be reconstructed into thicker slices to reduce the effect of image noise. Finally, the optimum display for the images must be chosen, so that the information contained in the SPECT data can be easily perceived by the clinician. (orig.) [de

  11. Potential role of a new hand-held miniature gamma camera in performing minimally invasive parathyroidectomy

    Energy Technology Data Exchange (ETDEWEB)

    Ortega, Joaquin; Lledo, Salvador [University of Valencia, Clinic University Hospital, Department of Surgery, Valencia (Spain); Ferrer-Rebolleda, Jose [Clinic University Hospital, Department of Nuclear Medicine, Valencia (Spain); Cassinello, Norberto [Clinic University Hospital, Unit of Endocrinologic and Bariatric Surgery, Valencia (Spain)

    2007-02-15

    Sestamibi scans have increased the use of minimally invasive parathyroidectomy (MIP) to treat primary hyperparathyroidism (PHPT) when caused by a parathyroid single adenoma. The greatest concern for surgeons remains the proper identification of pathological glands in a limited surgical field. We have studied the usefulness of a new hand-held miniature gamma camera (MGC) when used intraoperatively to locate parathyroid adenomas. To our knowledge this is the first report published on this subject in the scientific literature. Five patients with PHPT secondary to a single adenoma, positively diagnosed by preoperative sestamibi scans, underwent a MIP. A gamma probe for radioguided surgery and the new hand-held MGC were used consecutively to locate the pathological glands. This new MGC has a module composed of a high-resolution interchangeable collimator and a CsI(Na) scintillating crystal. It has dimensions of around 15 cm x 8 cm x 9 cm and weighs 1 kg. The intraoperative assay of PTH (ioPTH) was used to confirm the complete resection of pathological tissue. All cases were operated on successfully by a MIP. The ioPTH confirmed the excision of all pathological tissues. The MGC proved its usefulness in all patients, even in a difficult case in which the first attempt with the gamma probe failed. In all cases it offered real-time accurate intraoperative images. The hand-held MGC is a useful instrument in MIP for PHPT. It may be used to complement the standard tools used to date, or may even replace them, at least in selected cases of single adenomas. (orig.)

  12. Potential role of a new hand-held miniature gamma camera in performing minimally invasive parathyroidectomy

    International Nuclear Information System (INIS)

    Ortega, Joaquin; Lledo, Salvador; Ferrer-Rebolleda, Jose; Cassinello, Norberto

    2007-01-01

    Sestamibi scans have increased the use of minimally invasive parathyroidectomy (MIP) to treat primary hyperparathyroidism (PHPT) when caused by a parathyroid single adenoma. The greatest concern for surgeons remains the proper identification of pathological glands in a limited surgical field. We have studied the usefulness of a new hand-held miniature gamma camera (MGC) when used intraoperatively to locate parathyroid adenomas. To our knowledge this is the first report published on this subject in the scientific literature. Five patients with PHPT secondary to a single adenoma, positively diagnosed by preoperative sestamibi scans, underwent a MIP. A gamma probe for radioguided surgery and the new hand-held MGC were used consecutively to locate the pathological glands. This new MGC has a module composed of a high-resolution interchangeable collimator and a CsI(Na) scintillating crystal. It has dimensions of around 15 cm x 8 cm x 9 cm and weighs 1 kg. The intraoperative assay of PTH (ioPTH) was used to confirm the complete resection of pathological tissue. All cases were operated on successfully by a MIP. The ioPTH confirmed the excision of all pathological tissues. The MGC proved its usefulness in all patients, even in a difficult case in which the first attempt with the gamma probe failed. In all cases it offered real-time accurate intraoperative images. The hand-held MGC is a useful instrument in MIP for PHPT. It may be used to complement the standard tools used to date, or may even replace them, at least in selected cases of single adenomas. (orig.)

  13. Evaluation of role of brain SPECT in diagnosis of post stroke dementia

    International Nuclear Information System (INIS)

    Yousepour, G.; Alavi, M.

    2003-01-01

    Post stroke dementia is one of the most common complications of stroke that is preventable and relatively treatable too. The purpose of the study is comparison between the positive findings in the brain CT scan and brain perfusion SPECT. 15 patients who were complicated by dementia after cerebrovascular accident and also 5 patients as a control group enrolled in this study. Brain CT scan and brain SPECT were performed during at most one week after stroke. Abnormal findings in both brain CT scan and SPECT were seen in 46% of patients. Brain CT scan disclosed more abnormal findings compared to brain SPECT (33.3%). While brain SPECT findings were more information than brain CT scan (20%) this study is indicating that brain CT scan and the brain SPECT concomitantly for each other in better diagnosis of post stroke dementia. We did not find any specific diagnostic pattern in brain SPECT of patients suffering from post stroke dementia. The low quality of brain SPECT in spite of uniformity of gamma camera may be suggestive of low quality of Iran produced ECD kit that needs further evaluation

  14. Gated SPECT evaluation of left ventricular function using a CZT camera and a fast low-dose clinical protocol: comparison to cardiac magnetic resonance imaging

    Energy Technology Data Exchange (ETDEWEB)

    Giorgetti, Assuero; Masci, Pier Giorgio; Marras, Gavino; Gimelli, Alessia; Genovesi, Dario; Lombardi, Massimo [Fondazione CNR/Regione Toscana ' ' G. Monasterio' ' , Pisa (Italy); Rustamova, Yasmine K. [Azerbaijan Medical University, Department of internal medicine Central Customs Hospital, Baku (Azerbaijan); Marzullo, Paolo [Istituto di Fisiologia Clinica del CNR, Pisa (Italy)

    2013-12-15

    CZT technology allows ultrafast low-dose myocardial scintigraphy but its accuracy in assessing left ventricular function is still to be defined. The study group comprised 55 patients (23 women, mean age 63 {+-} 9 years) referred for myocardial perfusion scintigraphy. The patients were studied at rest using a CZT camera (Discovery NM530c; GE Healthcare) and a low-dose {sup 99m}Tc-tetrofosmin clinical protocol (mean dose 264 {+-} 38 MBq). Gated SPECT imaging was performed as a 6-min list-mode acquisition, 15 min after radiotracer injection. Images were reformatted (8-frame to 16-frame) using Lister software on a Xeleris workstation (GE Healthcare) and then reconstructed with a dedicated iterative algorithm. Analysis was performed using Quantitative Gated SPECT (QGS) software. Within 2 weeks patients underwent cardiac magnetic resonance imaging (cMRI, 1.5-T unit CVi; GE Healthcare) using a 30-frame acquisition protocol and dedicated software for analysis (MASS 6.1; Medis). The ventricular volumes obtained with 8-frame QGS showed excellent correlations with the cMRI volumes (end-diastolic volume (EDV), r = 0.90; end-systolic volume (ESV), r = 0.94; p < 0.001). However, QGS significantly underestimated the ventricular volumes (mean differences: EDV, -39.5 {+-} 29 mL; ESV, -15.4 {+-} 22 mL; p < 0.001). Similarly, the ventricular volumes obtained with 16-frame QGS showed an excellent correlations with the cMRI volumes (EDV, r = 0.92; ESV, r = 0.95; p < 0.001) but with significant underestimations (mean differences: EDV, -33.2 {+-} 26 mL; ESV, -17.9 {+-} 20 mL; p < 0.001). Despite significantly lower values (47.9 {+-} 16 % vs. 51.2 {+-} 15 %, p < 0.008), 8-frame QGS mean ejection fraction (EF) was closely correlated with the cMRI values (r = 0.84, p < 0.001). The mean EF with 16-frame QGS showed the best correlation with the cMRI values (r = 0.91, p < 0.001) and was similar to the mean cMRI value (49.6 {+-} 16 %, p not significant). Regional analysis showed a good

  15. Estimated GFR (eGFR by prediction equation in staging of chronic kidney disease compared to gamma camera GFR

    Directory of Open Access Journals (Sweden)

    Mohammad Masum Alam

    2016-07-01

    Full Text Available Background: Glomerular filtration rate is an effective tool for diagnosis and staging of chronic kidney disease. The effect ofrenal insufficiency by different method of this tool among patients with CKD is controversial.Objective: The objec­tive of this study was to evaluate the performance of eGFR in staging of CKD compared to gamma camera based GFR.Methods: This cross sectional analytical study was conducted in the Department of Biochemistry Bangabandhu Sheikh Mujib Medical University (BSMMU with the collaboration with National Institute of Nuclear Medicine and Allied Sciences, BSMMU during the period of January 2011 to December 2012. Gama camera based GFR was estimated from DTP A reno gram and eGFR was estimated by three prediction equations. Comparison was done by Bland Altman agree­ment test to see the agreement on the measurement of GFR between three equation based eGFR method and gama camera based GFR method. Staging comparison was done by Kappa analysis to see the agreement between the stages identified by those different methods.Results: Bland-Altman agreement analysis between GFR measured by gamma camera, CG equation ,CG equation corrected by BSA and MDRD equation shows statistically significant. CKD stages determined by CG GFR, CG GFR corrected by BSA , MDRD GFR and gamma camera based GFR was compared by Kappa statistical analysis .The kappa value was 0.66, 0.77 and 0.79 respectively.Conclusions: This study findings suggest that GFR estimation by MDRD equation in CKD patients shows good agreement with gamma camera based GFR and for staging of CKD patients, eGFR by MDRD formula may be used as very effective tool in Bangladeshi population.

  16. Brain SPECT. SPECT in der Gehirndiagnostik

    Energy Technology Data Exchange (ETDEWEB)

    Feistel, H. (Erlangen-Nuernberg Univ., Erlangen (Germany). Nuklearmedizinische Klinik mit Poliklinik)

    1991-12-01

    Brain SPECT investigations have gained broad acceptance since the introduction of the lipophilic tracer Tc-99m-HMPAO. Depending on equipment and objectives in different departments, the examinations can be divided into three groups: 1. Under normal conditions and standardised patient preparation the 'rest' SPECT can be performed in every department with a tomographic camera. In cerebrovascular disease there is a demand for determination of either the perfusion reserve in reversible ischemia or prognostic values in completed stroke. In cases of dementia, SPECT may yield useful results according to differential diagnosis. Central cerebral system involvement in immunologic disease may be estimated with higher sensitivity than in conventional brain imaging procedures. In psychiatric diseases there is only a relative indication for brain SPECT, since results during recent years have been contradictory and may be derived only in interventional manner. In brain tumor diagnostics SPECT with Tl-201 possibly permits grading. In inflammatory disease, especially in viral encephalitis, SPECT may be used to obtain early diagnosis. Normal pressure hydrocephalus can be distinguished from other forms of dementia and, consequently, the necessity for shunting surgery can be recognised. 2. In departments equipped for emergency cases an 'acute' SPECT can be performed in illnesses with rapid changing symptoms such as different forms of migraine, transient global amnesia, epileptic seizures (so-called 'ictal SPECT') or urgent forms like trauma. 3. In cooperation with several departments brain SPECT can be practised as an interventional procedure in clinical and in scientific studies. (orig./MG).

  17. Performance of the prototype LaBr{sub 3} spectrometer developed for the JET gamma-ray camera upgrade

    Energy Technology Data Exchange (ETDEWEB)

    Rigamonti, D., E-mail: davide.rigamonti@mib.infn.it; Nocente, M.; Gorini, G. [Dipartimento di Fisica “G. Occhialini,” Università degli Studi di Milano-Bicocca, Milano (Italy); Istituto di Fisica del Plasma “P. Caldirola,” CNR, Milano (Italy); Muraro, A.; Giacomelli, L.; Cippo, E. P.; Tardocchi, M. [Istituto di Fisica del Plasma “P. Caldirola,” CNR, Milano (Italy); Perseo, V. [Dipartimento di Fisica “G. Occhialini,” Università degli Studi di Milano-Bicocca, Milano (Italy); Boltruczyk, G.; Gosk, M.; Korolczuk, S.; Mianowski, S.; Zychor, I. [Narodowe Centrum Badań Jądrowych (NCBJ), 05-400 Otwock-Swierk (Poland); Fernandes, A.; Pereira, R. C. [Instituto de Plasmas e Fusão Nuclear, Instituto Superior Técnico, Universidade de Lisboa, Lisboa (Portugal); Figueiredo, J. [Instituto de Plasmas e Fusão Nuclear, Instituto Superior Técnico, Universidade de Lisboa, Lisboa (Portugal); EUROfusion Programme Management Unit, Culham Science Centre, OX14 3DB Abingdon (United Kingdom); Kiptily, V. [Culham Science Centre for Fusion Energy, Culham (United Kingdom); Murari, A. [EUROfusion Programme Management Unit, Culham Science Centre, OX14 3DB Abingdon (United Kingdom); Consorzio RFX (CNR, ENEA, INFN, Universita’ di Padova, Acciaierie Venete SpA), Padova (Italy); Collaboration: EUROfusion Consortium, JET, Culham Science Centre, Abingdon OX14 3DB (United Kingdom)

    2016-11-15

    In this work, we describe the solution developed by the gamma ray camera upgrade enhancement project to improve the spectroscopic properties of the existing JET γ-ray camera. Aim of the project is to enable gamma-ray spectroscopy in JET deuterium-tritium plasmas. A dedicated pilot spectrometer based on a LaBr{sub 3} crystal coupled to a silicon photo-multiplier has been developed. A proper pole zero cancellation network able to shorten the output signal to a length of 120 ns has been implemented allowing for spectroscopy at MHz count rates. The system has been characterized in the laboratory and shows an energy resolution of 5.5% at E{sub γ} = 0.662 MeV, which extrapolates favorably in the energy range of interest for gamma-ray emission from fast ions in fusion plasmas.

  18. A study of effects of scattered reaction on physical parameters of a new gamma camera used in nuclear medicine

    International Nuclear Information System (INIS)

    Maury, Martine.

    1979-01-01

    This work is devoted to the analysis of the performance of a new gamma camera. This camera is characterized by the introduction of an image amplifier between the crystal detector and the localization system which compound four photomultipliers. The appreciation of performances of this new instrument is based on the measure of the physical parameters usually studied in this purpose: energy resolution, spatial resolution, modulation transfert fonction and contrast, sensitivity and deadtime. Furthermore, we have studied the influence of scattered radiation on the value of these parameters. Two studies complete this work: the artificial deterioration of the energy resolution of the camera inserting a noise, to estimate the importance of the energy resolution on the image contrast; the scanning of pulse amplitude spectra obtained from brain of patients in order to evaluate the participation of scattered radiation in the peak's constitution. We present, at last, a quality control programm for scintillation camera [fr

  19. FACT-The first Cherenkov telescope using a G-APD camera for TeV gamma-ray astronomy

    International Nuclear Information System (INIS)

    Anderhub, H.; Backes, M.; Biland, A.; Boller, A.; Braun, I.; Bretz, T.; Commichau, S.; Commichau, V.; Domke, M.; Dorner, D.; Gendotti, A.; Grimm, O.; Gunten, H. von; Hildebrand, D.; Horisberger, U.; Koehne, J.-H.; Kraehenbuehl, T.; Kranich, D.; Krumm, B.; Lorenz, E.

    2011-01-01

    Geiger-mode Avalanche Photodiodes (G-APD) bear the potential to significantly improve the sensitivity of Imaging Air Cherenkov Telescopes (IACT). We are currently building the First G-APD Cherenkov Telescope (FACT) by refurbishing an old IACT with a mirror area of 9.5 square meters and are constructing a new, fine-pixelized camera using novel G-APDs. The main goal is to evaluate the performance of a complete system by observing very high energy gamma-rays from the Crab Nebula. This is an important field test to check the feasibility of G-APD-based cameras to replace at some time the PMT-based cameras of planned future IACTs like AGIS and CTA. In this article, we present the basic design of such a camera as well as some important details.

  20. Development of the monitoring system of plasma behavior using a CCD camera in the GAMMA 10 tandem mirror

    International Nuclear Information System (INIS)

    Kawano, Hirokazu; Nakashima, Yousuke; Higashizono, Yuta

    2007-01-01

    In the central-cell of the GAMMA 10 tandem mirror, a medium-speed camera (CCD camera, 400 frames per second, 216 x 640 pixel) has been installed for the observation of plasma behavior. This camera system is designed for monitoring the plasma position and movement in the whole discharge duration. The captured two-dimensional (2-D) images are automatically displayed just after the plasma shot and stored sequentially shot by shot. This system has been established as a helpful tool for optimizing the plasma production and heating systems by measuring the plasma behavior in several experimental conditions. The camera system shows that the intensity of the visible light emission on the central-cell limiter accompanied by central electron cyclotron heating (C-ECH) correlate with the wall conditioning and immersion length of a movable limiter (iris limiter) in the central cell. (author)

  1. Improved quantification in single-pinhole and multiple-pinhole SPECT using micro-CT information

    International Nuclear Information System (INIS)

    Vanhove, Christian; Bossuyt, Axel; Defrise, Michel; Lahoutte, Tony

    2009-01-01

    The purpose of this study was to demonstrate the feasibility of accurate quantification in pinhole SPECT using micro-CT information. Pinhole SPECT scans were performed using a clinical dual-head gamma camera. Each pinhole SPECT scan was followed by a micro-CT acquisition. Functional and anatomical images were coregistered using six point sources visible with both modalities. Pinhole SPECT images were reconstructed iteratively. Attenuation correction was based on micro-CT information. Scatter correction was based on dual and triple-energy window methods. Phantom and animal experiments were performed. A phantom containing nine vials was filled with different concentrations of 99m Tc. Three vials were also filled with CT contrast agent to increase attenuation. Activity concentrations measured on the pinhole SPECT images were compared with activity concentrations measured by the dose calibrator. In addition, 11 mice were injected with 99m Tc-labelled Nanobodies. After acquiring functional and anatomical images, the animals were killed and the liver activity was measured using a gamma-counter. Activity concentrations measured on the reconstructed images were compared with activity concentrations measured with the gamma counter. The phantom experiments demonstrated an average error of -27.3 ± 15.9% between the activity concentrations measured on the uncorrected pinhole SPECT images and in the dose calibrator. This error decreased significantly to -0.1 ± 7.3% when corrections were applied for nonuniform attenuation and scatter. The animal experiment revealed an average error of -18.4 ± 11.9% between the activity concentrations measured on the uncorrected pinhole SPECT images and measured with the gamma counter. This error decreased to -7.9 ± 10.4% when attenuation and scatter correction was applied. Attenuation correction obtained from micro-CT data in combination with scatter correction allows accurate quantification in pinhole SPECT. (orig.)

  2. Diagnostic impact of SPECT-CT in the assessment of endocrine tumors

    International Nuclear Information System (INIS)

    El Badaoui, A.; Clermont, H. de; Valli, N.; Caignon, J.M.; Fernandez, P.; Allard, M.; Barat, J.L.; Ducassou, D.; Clermont, H. de; Valli, N.; Caignon, J.M.; Fernandez, P.; Allard, M.; Barat, J.L.; Ducassou, D.; Clermont, H. de; Allard, M.

    2008-01-01

    Image fusion using single photon emission computed tomography - computed tomography (SPECT - CT) associates functional and morphological images. This study evaluates the added value of SPECT- CT, obtained with a hybrid SPECT- CT gamma camera, on anatomic localization and diagnostic impact in assessment of endocrine tumours and pheochromocytomas. Method: Six months prospective study was undertaken including 33 consecutive exams encompassing 20 Somatostatin Receptor Scintigraphies (S.R.S.) and 13 123 I-meta-iodo-benzyl-guanidine (Mibg) scans. Two experienced nuclear medicine physicians independently analysed independently planar and SPECT images in a first time, then, SPECT- CT fused images in a second time. They evaluated two parameters: SPECT- CT impact on anatomic localization (L.A.) and its diagnostic impact (I.D.). Each parameter was scored according three levels of evaluation. Results: An added value of SPECT- CT images was evidenced in 55% of cases on the anatomic localization and in 41% of the patients on the diagnostic impact. Therefore, a more important benefit was noted when SPECT was positive (L.A.: 90%; I.D.: 70%) than when it was negative (L.A.: 15%; I.D.: 8%). Furthermore, the added value proved higher for the S;R.S. compared to Mibg scans. Conclusion: SPECT- CT fusion images obtained by a hybrid system is more relevant to determine anatomic localization and more accurate than SPECT alone, particularly in the assessment of endocrine tumours. The added value of SPECT- CT seems to be lower for Mibg scans in the assessment of pheochromocytomas. (authors)

  3. Imaging of radiocesium uptake dynamics in a plant body using a newly developed high-resolution gamma camera for radiocesium

    Energy Technology Data Exchange (ETDEWEB)

    Kawachi, Naoki; Yin, Yong-Gen; Suzui, Nobuo; Ishii, Satomi; Fujimaki, Shu [Radiotracer Imaging Gr., Quantum Beam Science Directorate, Japan Atomic Energy Agency (JAEA), 1233 Watanuki, Takasaki, Gunma 370-1292 (Japan); Yoshihara, Toshihiro [Plant Molecular Biology, Laboratory of Environmental Science, Central Research Institute of Electric Power Industry (CRIEPI), 1646 Abiko, Chiba 270-1194 (Japan); Watabe, Hiroshi [Cyclotron and Radioisotope Center (CYRIC), Tohoku University, 6-3Aoba, Aramaki, Aoba-ku, Sendai, Miyagi, 980-8578 (Japan); Yamamoto, Seiichi [Department of Radiological and Medical Laboratory Sciences, Nagoya University Graduate School of Medicine, 1-1-20 Daiko-Minami, Higashi-ku, Nagoya 461-8673 (Japan)

    2014-07-01

    Vast agricultural and forest areas around the Tokyo Electric Power Company Fukushima Daiichi Nuclear Power Station in Japan were contaminated with radiocesium (Cs-134 and Cs-137) after the accident following the earthquake and tsunami in March 2011. A variety of agricultural studies, such as fertilizer management and plant breeding, have been undertaken intensively for reduction of radiocesium uptake in crops, or, enhancement of uptake in phyto-remediation. In this study, we newly developed a gamma camera specific for plant nutritional research, and performed quantitative analyses on uptake and partitioning of radiocesium in intact plant bodies. In general, gamma camera is a common technology in medical imaging, but it is not applicable to high-energy gamma rays such as emissions from Cs-137 (662 keV). Therefore, we designed our new gamma camera to prevent the penetration and scattering of the high-energy gamma rays. A single-crystal scintillator, Ce-doped Gd{sub 3}Al{sub 2}Ga{sub 3}O{sub 12} (Ce:GAGG), was employed, which has a relatively high density, a large light output, no natural radioactivity and no hygroscopicity. A 44 x 44 matrix of the Ce:GAGG pixels, with dimensions of 0.85 mm x 0.85 mm x 10 mm for each pixel, was coupled to a high-quantum efficiency position sensitive photomultiplier tube. This gamma detector unit was encased in a 20-mm-thick tungsten container with a tungsten pinhole collimator on the front. By using this gamma camera, soybean plants (Glycine max), grown in hydroponic solutions and fed with 1-2 MBq of Cs-137, were imaged for 6.5 days in maximum to investigate and visualize the uptake dynamics into/within the areal part. As a result, radiocesium gradually appeared in the shoot several hours after feeding of Cs-137, and then accumulated intensively in the maturing pods and seeds in a characteristic pattern. Our results also demonstrated that this gamma-camera method enables quantitative evaluation of plant ability to absorb, transport

  4. Stress-first protocol for myocardial perfusion SPECT imaging with semiconductor cameras: high diagnostic performances with significant reduction in patient radiation doses

    International Nuclear Information System (INIS)

    Perrin, Mathieu; Claudin, Marine; Veran, Nicolas; Morel, Olivier; Besseau, Cyril; Boutley, Henri; Djaballah, Wassila; Poussier, Sylvain; Verger, Antoine; Moulin, Frederic; Imbert, Laetitia; Karcher, Gilles; Marie, Pierre-Yves

    2015-01-01

    Effective doses of 14 mSv or higher are currently being attained in patients having stress and rest myocardial perfusion imaging (MPI) single photon emission computed tomography (SPECT) performed on the same day with conventional protocols. This study aimed to assess the actual reduction in effective doses as well as diagnostic performances for MPI routinely planned with: (1) high-sensitivity cadmium zinc telluride (CZT) cameras, (2) very low injected activities and (3) a stress-first protocol where the normality of stress images may lead to avoiding rest imaging. During a 1-year period, 2,845 patients had MPI on a CZT camera, a single-day stress-first protocol and low injected activities (120 MBq of 99m Tc-sestamibi at stress for 75 kg body weight and threefold higher at rest). The ability to detect > 50 % coronary stenosis was assessed in a subgroup of 149 patients who also had coronary angiography, while the normalcy rate was assessed in a subgroup of 128 patients with a low pretest likelihood of coronary artery disease (<10 %). Overall, 33 % of patients had abnormal MPI of which 34 % were women and 34 % were obese. The mean effective doses and the percentage of exams involving only stress images were: (1) 3.53 ± 2.10 mSv and 37 % in the overall population, (2) 4.83 ± 1.56 mSv and 5 % in the subgroup with angiography and (3) 1.96 ± 1.52 mSv and 71 % in the low-probability subgroup. Sensitivity and global accuracy for identifying the 106 patients with coronary stenosis were 88 and 80 %, respectively, while the normalcy rate was 97 %. When planned with a low-dose stress-first protocol on a CZT camera, MPI provides high diagnostic performances and a dramatic reduction in patient radiation doses. This reduction is even greater in low-risk subgroups with high rates of normal stress images, thus allowing the mean radiation dose to be balanced against cardiac risk in targeted populations. (orig.)

  5. Development of a Compton camera for prompt-gamma medical imaging

    Science.gov (United States)

    Aldawood, S.; Thirolf, P. G.; Miani, A.; Böhmer, M.; Dedes, G.; Gernhäuser, R.; Lang, C.; Liprandi, S.; Maier, L.; Marinšek, T.; Mayerhofer, M.; Schaart, D. R.; Lozano, I. Valencia; Parodi, K.

    2017-11-01

    A Compton camera-based detector system for photon detection from nuclear reactions induced by proton (or heavier ion) beams is under development at LMU Munich, targeting the online range verification of the particle beam in hadron therapy via prompt-gamma imaging. The detector is designed to be capable to reconstruct the photon source origin not only from the Compton scattering kinematics of the primary photon, but also to allow for tracking of the secondary Compton-scattered electrons, thus enabling a γ-source reconstruction also from incompletely absorbed photon events. The Compton camera consists of a monolithic LaBr3:Ce scintillation crystal, read out by a multi-anode PMT acting as absorber, preceded by a stacked array of 6 double-sided silicon strip detectors as scatterers. The detector components have been characterized both under offline and online conditions. The LaBr3:Ce crystal exhibits an excellent time and energy resolution. Using intense collimated 137Cs and 60Co sources, the monolithic scintillator was scanned on a fine 2D grid to generate a reference library of light amplitude distributions that allows for reconstructing the photon interaction position using a k-Nearest Neighbour (k-NN) algorithm. Systematic studies were performed to investigate the performance of the reconstruction algorithm, revealing an improvement of the spatial resolution with increasing photon energy to an optimum value of 3.7(1)mm at 1.33 MeV, achieved with the Categorical Average Pattern (CAP) modification of the k-NN algorithm.

  6. A prototype small CdTe gamma camera for radioguided surgery and other imaging applications.

    Science.gov (United States)

    Tsuchimochi, Makoto; Sakahara, Harumi; Hayama, Kazuhide; Funaki, Minoru; Ohno, Ryoichi; Shirahata, Takashi; Orskaug, Terje; Maehlum, Gunnar; Yoshioka, Koki; Nygard, Einar

    2003-12-01

    Gamma probes have been used for sentinel lymph node biopsy in melanoma and breast cancer. However, these probes can provide only radioactivity counts and variable pitch audio output based on the intensity of the detected radioactivity. We have developed a small semiconductor gamma camera (SSGC) that allows visualisation of the size, shape and location of the target tissues. This study is designed to characterise the performance of the SSGC for radioguided surgery of metastatic lesions and for other imaging applications amenable to the smaller format of this prototype imaging system. The detector head had 32 cadmium telluride semiconductor arrays with a total of 1,024 pixels, and with application-specific integrated circuits (ASICs) and a tungsten collimator. The entire assembly was encased in a lead housing measuring 152 mmx166 mmx65 mm. The effective visual field was 44.8 mmx44.8 mm. The energy resolution and imaging aspects were tested. Two spherical 5-mm- and 15-mm-diameter technetium-99m radioactive sources that had activities of 0.15 MBq and 100 MBq, respectively, were used to simulate a sentinel lymph node and an injection site. The relative detectability of these foci by the new detector and a conventional scintillation camera was studied. The prototype was also examined in a variety of clinical applications. Energy resolution [full-width at half-maximum (FWHM)] for a single element at the centre of the field of view was 4.2% at 140 keV (99mTc), and the mean energy resolution of the CdTe detector arrays was approximately 7.8%. The spatial resolution, represented by FWHM, had a mean value of 1.56 +/- 0.05 mm. Simulated node foci could be visualised clearly by the SSGC using a 15-s acquisition time. In preliminary clinical tests, the SSGC successfully imaged diseases in a variety of tissues, including salivary and thyroid glands, temporomandibular joints and sentinel lymph nodes. The SSGC has significant potential for diagnosing diseases and facilitating

  7. A prototype small CdTe gamma camera for radioguided surgery and other imaging applications

    Energy Technology Data Exchange (ETDEWEB)

    Tsuchimochi, Makoto; Hayama, Kazuhide [Department of Oral and Maxillofacial Radiology, The Nippon Dental University School of Dentistry at Niigata, 1-8 Hamaura-cho, 951-8580, Niigata (Japan); Sakahara, Harumi [Department of Radiology, Hamamatsu University School of Medicine, Hamamatsu (Japan); Funaki, Minoru; Ohno, Ryoichi; Shirahata, Takashi [Acrorad Co. Ltd., Tokyo (Japan); Orskaug, Terje; Maehlum, Gunnar; Yoshioka, Koki; Nygard, Einar [Integrated Detector and Electronics A.S (IDE AS), Hovik (Norway)

    2003-12-01

    Gamma probes have been used for sentinel lymph node biopsy in melanoma and breast cancer. However, these probes can provide only radioactivity counts and variable pitch audio output based on the intensity of the detected radioactivity. We have developed a small semiconductor gamma camera (SSGC) that allows visualisation of the size, shape and location of the target tissues. This study is designed to characterise the performance of the SSGC for radioguided surgery of metastatic lesions and for other imaging applications amenable to the smaller format of this prototype imaging system. The detector head had 32 cadmium telluride semiconductor arrays with a total of 1,024 pixels, and with application-specific integrated circuits (ASICs) and a tungsten collimator. The entire assembly was encased in a lead housing measuring 152 mm x 166 mm x 65 mm. The effective visual field was 44.8 mm x 44.8 mm. The energy resolution and imaging aspects were tested. Two spherical 5-mm- and 15-mm-diameter technetium-99m radioactive sources that had activities of 0.15 MBq and 100 MBq, respectively, were used to simulate a sentinel lymph node and an injection site. The relative detectability of these foci by the new detector and a conventional scintillation camera was studied. The prototype was also examined in a variety of clinical applications. Energy resolution [full-width at half-maximum (FWHM)] for a single element at the centre of the field of view was 4.2% at 140 keV ({sup 99m}Tc), and the mean energy resolution of the CdTe detector arrays was approximately 7.8%. The spatial resolution, represented by FWHM, had a mean value of 1.56{+-}0.05 mm. Simulated node foci could be visualised clearly by the SSGC using a 15-s acquisition time. In preliminary clinical tests, the SSGC successfully imaged diseases in a variety of tissues, including salivary and thyroid glands, temporomandibular joints and sentinel lymph nodes. The SSGC has significant potential for diagnosing diseases and

  8. A prototype small CdTe gamma camera for radioguided surgery and other imaging applications

    International Nuclear Information System (INIS)

    Tsuchimochi, Makoto; Hayama, Kazuhide; Sakahara, Harumi; Funaki, Minoru; Ohno, Ryoichi; Shirahata, Takashi; Orskaug, Terje; Maehlum, Gunnar; Yoshioka, Koki; Nygard, Einar

    2003-01-01

    Gamma probes have been used for sentinel lymph node biopsy in melanoma and breast cancer. However, these probes can provide only radioactivity counts and variable pitch audio output based on the intensity of the detected radioactivity. We have developed a small semiconductor gamma camera (SSGC) that allows visualisation of the size, shape and location of the target tissues. This study is designed to characterise the performance of the SSGC for radioguided surgery of metastatic lesions and for other imaging applications amenable to the smaller format of this prototype imaging system. The detector head had 32 cadmium telluride semiconductor arrays with a total of 1,024 pixels, and with application-specific integrated circuits (ASICs) and a tungsten collimator. The entire assembly was encased in a lead housing measuring 152 mm x 166 mm x 65 mm. The effective visual field was 44.8 mm x 44.8 mm. The energy resolution and imaging aspects were tested. Two spherical 5-mm- and 15-mm-diameter technetium-99m radioactive sources that had activities of 0.15 MBq and 100 MBq, respectively, were used to simulate a sentinel lymph node and an injection site. The relative detectability of these foci by the new detector and a conventional scintillation camera was studied. The prototype was also examined in a variety of clinical applications. Energy resolution [full-width at half-maximum (FWHM)] for a single element at the centre of the field of view was 4.2% at 140 keV ( 99m Tc), and the mean energy resolution of the CdTe detector arrays was approximately 7.8%. The spatial resolution, represented by FWHM, had a mean value of 1.56±0.05 mm. Simulated node foci could be visualised clearly by the SSGC using a 15-s acquisition time. In preliminary clinical tests, the SSGC successfully imaged diseases in a variety of tissues, including salivary and thyroid glands, temporomandibular joints and sentinel lymph nodes. The SSGC has significant potential for diagnosing diseases and facilitating

  9. Design and implementation of a quality assurance program for gamma cameras

    International Nuclear Information System (INIS)

    Montoya M, A.; Rodriguez L, A.; Trujillo Z, F. E.

    2010-09-01

    In nuclear medicine more than 90% of the carried out procedures are diagnostic. To assure an appropriate diagnostic quality of the images and the doses optimization received by the patients originated in the radioactive material, it is indispensable the periodic surveillance of the operation and performance of the equipment s by means of quality assurance tests. This work presents a proposal of a quality assurance program for gamma cameras based on recommendations of the IAEA, the American Association of Medical Physics and the National Electrical Manufacturers Association. Some tests of the program were applied to an e.cam gamma camera (Siemens) of the Nuclear Medicine Department of the National Institute of Cancer. The intrinsic and extrinsic uniformity, the intrinsic spatial resolution and the extrinsic sensibility were verified. For intrinsic uniformity the average daily values of the integral uniformity and differential uniformity in the useful vision field were 2.61% and 1.58% respectively, the average monthly values of intrinsic uniformity for the integral and differential uniformity in the useful vision field were 4.10% and 1.66% respectively. The used acceptance criterions were respectively of 3.74% and 2.74%. The average values of extrinsic uniformity for the useful vision field were of 7.65% (intrinsic uniformity) and 2.69% (extrinsic uniformity), in this case the acceptance criterion is a value of 6.00%. The average value of intrinsic spatial resolution went 4.67 mm superior to 4.4. mm that is the acceptance limit. Finally, maximum variations of 1.8% were observed (minors than 2% that is the acceptance criterion) for the extrinsic sensibility measured in different regions of the detector. Significant variations of extrinsic sensibility were not observed among the monthly lectures. Of the realized measurements was concluded that the system requires of a maintenance service by part of the manufacturer, which one carries out later on to this work. The

  10. Brain SPECT using dipyridamole for evaluation of vascular reserve

    International Nuclear Information System (INIS)

    Kim, Su Zy; Park, Chan Hee; Yoon, Soo Hwan; Pai, Moon Sun; Yoon, Suk Nam; Cho, Kyung Kee

    1997-01-01

    Baseline and stress brain SPECT studies using CO 2 inhalation, acetazolamide (Diamox R ) and adenosine administrations have been used in the evaluation of cerebral vascular reserve. Recently dipyridamole (Persantine R ) which is one of the pharmacologic myocardial perfusion SPECT agents as a potent vasodilator is suggested as another cerebral vasodilator. IV Diamox R is not available in Korea. Therefore, the purpose of our study was to evaluate dipyridamole in stress brain SPECT in patients with Moya Moya disease. Eight patients with angiographically proven Moya Moya disease were studied. Their ages ranged from 7 to 62 year old. There were 4 males and 4 females. Each patient had a baseline and persantine brain SPECT studies with 1 to 3 days' interval. Dipyridamole was given intravenously at a dose of 0.56 mg/kg over 4 minutes while watching vital signs such as blood pressure, heart rate, and electrocardiogram. Three minutes after the completion of the infusion, 99mTc-ECD (0.2 mCi/Ib body weight) was injected. Brain SPECT was performed 30 minutes later using a tripple head gamma camera equipped with LEHR collimators. A total of 128 projections with an acquisition time of 30 second per projection was obtained and reconstructed by filtered back projections without attenuation correction. The difference between the baseline and persantine studies was analysed by visual and semiquantitavely. During the infusion of persantine, heart rate, blood pressure and side effects such as headache, chest discomfort were similar to the persantine myocardial SPECT studies. Five of eight patients showed a significant decrease in rCBF on persantine brain SPECT in comparison to the baseline study. The remaining three revealed no significant change in rCBF. Our study suggests that the dipyridamole stress brain SPECT is feasible and useful in assessing cerebral blood flow reserve. However we need to evaluate more number of patients in the future

  11. Iterative reconstruction of SiPM light response functions in a square-shaped compact gamma camera

    Science.gov (United States)

    Morozov, A.; Alves, F.; Marcos, J.; Martins, R.; Pereira, L.; Solovov, V.; Chepel, V.

    2017-05-01

    Compact gamma cameras with a square-shaped monolithic scintillator crystal and an array of silicon photomultipliers (SiPMs) are actively being developed for applications in areas such as small animal imaging, cancer diagnostics and radiotracer guided surgery. Statistical methods of position reconstruction, which are potentially superior to the traditional centroid method, require accurate knowledge of the spatial response of each photomultiplier. Using both Monte Carlo simulations and experimental data obtained with a camera prototype, we show that the spatial response of all photomultipliers (light response functions) can be parameterized with axially symmetric functions obtained iteratively from flood field irradiation data. The study was performed with a camera prototype equipped with a 30  ×  30  ×  2 mm3 LYSO crystal and an 8  ×  8 array of SiPMs for 140 keV gamma rays. The simulations demonstrate that the images, reconstructed with the maximum likelihood method using the response obtained with the iterative approach, exhibit only minor distortions: the average difference between the reconstructed and the true positions in X and Y directions does not exceed 0.2 mm in the central area of 22  ×  22 mm2 and 0.4 mm at the periphery of the camera. A similar level of image distortions is shown experimentally with the camera prototype.

  12. Evaluation of intrinsic uniformity of gamma camera in the Servicio de Medicina Nuclear at the Hospital San Juan de Dios

    International Nuclear Information System (INIS)

    Mora Ramirez, Erick

    2007-01-01

    The quality assurance program in a nuclear medicine department aims to minimize errors and artifacts that cover all aspects of clinical practice. The quality control can be seen such as one particular procedure used to meet measurements that can be followed along the time. The intrinsic flood-field uniformity is one of the quality control procedures to evaluate the response of a gamma camera to a spatially uniform flux of an incident gamma radiation over the field of view. The gamma cameras, recording the integral and differential uniformity figures of the intrinsic uniformity during the 2007, were evaluated in order to establish how well the instruments were working. An evaluation of the acquisition protocol which implies the variation of the acquired counts, the energy window width and its placement was performed at the beginning. After that the recorded data were analyzed creating plots which were showing the performance of the systems. Using an energy window placed at 140 keV at 20 %, with matrix size of 512 x 512, acquiring 15 million counts and the source activity close to 700 μC; it was thought that good enough images and uniformities are obtained. Both are within the manufactures requirements; however, increasing the number of acquired counts, images are much better and an improvement in the evaluated parameters can be seen. The performance evaluation of the three gamma cameras was taking into account for approximately 240 days, showing an integral uniformity range of 1.04 - 3.5 % and the range for differential uniformity vary from 0.88 up to 2.7 %. It concludes that the gamma cameras were working quite well, no need to vary the acquisition protocol because it is good enough to perform this test. Also, factors affecting the quality of the images are radioactive waste material not very well shielded and temperature room variations, especially at the beginning of the workday. (author) [es

  13. Radioguided Parathyroidectomy with Portable Mini Gamma-Camera for the Treatment of Primary Hyperparathyroidism

    Directory of Open Access Journals (Sweden)

    Claudio Casella

    2015-01-01

    Full Text Available Background. A proper localisation of pathological parathyroid glands is essential for a minimally invasive approach in the surgical treatment of primary hyperparathyroidism (PHP. The recent introduction of portable mini gamma-cameras (pMGCs enabled intraoperative scintigraphic scanning. The aim of our study is to evaluate the efficacy of this new method and compare it with the preoperative localisation surveys. Methods. 20 patients were studied; they were evaluated preoperatively by neck ultrasound and Tc-sestaMIBI-scintigraphy and intraoperatively with the pMGC IP Guardian 2. The results obtained from the three evaluations were compared. Results. The pMGC presented a sensitivity of 95%, a specificity of 98.89%, and a diagnostic accuracy of 98.18%, which were higher than those of preoperative ultrasound (sensitivity 55%; specificity 95%; diagnostic accuracy 87% and scintigraphy with Tc-sestaMIBI (sensitivity 73.68%; specificity 96.05%; diagnostic accuracy 91.58%. Conclusions. The pMGC can be used effectively as an intraoperative method to find the correct location of the pathological parathyroid glands. The pMGC is more reliable than the currently used preoperative and intraoperative localisation techniques.

  14. The review of myocardial positron emission computed tomography and positron imaging by gamma camera

    Energy Technology Data Exchange (ETDEWEB)

    Ohtake, Tohru [Tokyo Univ. (Japan). Faculty of Medicine

    1998-04-01

    To measure myocardial blood flow, Nitrogen-13 ammonia, Oxygen-15 water, Rubidium-82 and et al. are used. Each has merit and demerit. By measuring myocardial coronary flow reserve, the decrease of flow reserve during dipyridamole in patients with hypercholesterolemia or diabetes mellitus without significant coronary stenosis was observed. The possibility of early detection of atherosclerosis was showed. As to myocardial metabolism, glucose metabolism is measured by Fluorine-18 fluorodeoxyglucose (FDG), and it is considered as useful for the evaluation of myocardial viability. We are using FDG to evaluate insulin resistance during insulin clamp in patients with diabetes mellitus by measuring glucose utilization rate of myocardium and skeletal muscle. FFA metabolism has been measured by {sup 11}C-palmitate, but absolute quantification has not been performed. Recently the method for absolute quantification was reported, and new radiopharmaceutical {sup 18}F-FTHA was reported. Oxygen metabolism has been estimated by {sup 11}C-acetate. Myocardial viability, cardiac efficiency was evaluated by oxygen metabolism. As to receptor or sympathetic nerve end, cardiac insufficiency or cardiac transplantation was evaluated. Imaging of positron emitting radiopharmaceutical by gamma camera has been performed. Collimator method is clinically useful for cardiac imaging of viability study. (author). 54 refs.

  15. Measuring neutron fluences and gamma/x-ray fluxes with CCD cameras

    International Nuclear Information System (INIS)

    Yates, G.J.; Smith, G.W.; Zagarino, P.; Thomas, M.C.

    1991-01-01

    The capability to measure bursts of neutron fluences and gamma/x-ray fluxes directly with charge coupled device (CCD) cameras while being able to distinguish between the video signals produced by these two types of radiation, even when they occur simultaneously, has been demonstrated. Volume and area measurements of transient radiation-induced pixel charge in English Electric Valve (EEV) Frame Transfer (FT) charge coupled devices (CCDs) from irradiation with pulsed neutrons (14 MeV) and Bremsstrahlung photons (4--12 MeV endpoint) are utilized to calibrate the devices as radiometric imaging sensors capable of distinguishing between the two types of ionizing radiation. Measurements indicate ∼.05 V/rad responsivity with ≥1 rad required for saturation from photon irradiation. Neutron-generated localized charge centers or ''peaks'' binned by area and amplitude as functions of fluence in the 10 5 to 10 7 n/cm 2 range indicate smearing over ∼1 to 10% of CCD array with charge per pixel ranging between noise and saturation levels

  16. A gamma camera method to monitor the use of degradable starch microspheres in hepatic arterial chemotherapy

    International Nuclear Information System (INIS)

    Britten, A.; Fleming, J.; Flowerdew, A.; Hunt, T.; Taylor, I.; Ackery, D.

    1989-01-01

    A gamma camera method to quantify the haemodynamic effects of degradable starch microspheres (DSM) in intra arterial hepatic therapy is described. Results are presented from ten patients with colorectal liver metastases. Intra hepatic arterio venous shunting was present in 1 patient prior to DSM and in 2 subjects after three 300 mg DSM fractions. DSM reduced the rate of flow of injectate to the lung in all cases. Conversely, an increased rate of flow of injectate to gut or spleen occurred with 300 mg fractions of DSM in 7/9 cases. Lower dose DSM fractions are indicated. At 2-3 min after DSM injection the mean fraction of the activity retained in the liver was 0.22. A DSM induced enhancement of tumour relative to normal tissue perfusion was obtained in four out of five tumour regions identified. All indices showed a wide variation between patients and between individual DSM doses, and the high incidence of extra hepatic shunting confirms the need for monitoring when using intra arterial microspheres. (orig.)

  17. Relationship between image quality and changes in spatial resolution for the gamma camera

    International Nuclear Information System (INIS)

    Ikeda, Hozumi; Kishimoto, Kenji; Shimonishi, Yoshihiro; Ohmura, Masahiro; Kosakai, Kazuhisa; Hamada, Kunio; Ochi, Hironobu.

    1989-01-01

    The purpose of this study is to examine quantitatively the relationship between visual image quality and degradation in spatial resolution for a gamma camera by the increase in distance from collimator. The relationship between the proportion (p) of images identified the difference of image quality and the difference (δFWHM) in FWHM between paired images was showed in a sigmoid curve. Using Dendy's method, minimum level to be correctly identified the difference of image quality on three out of four occasions (p=0.75) was corresponded to 0.4 mm in δFWHM. Using fuzzy theory, the level to be identified the difference of image quality was examind under various conditions. The truth-value of fuzzy sets-degraded or slightly degraded and not-degraded in image quality between paired images-was gained the peak at 0.5 mm of δFWHM. It was founded that changes of 0.4-0.5 mm in FWHM-corresponding about 2 cm distance from collimator-could be sufficiently identified in the difference of image quality. (author)

  18. Applications of multi-pinhole gamma camera collimation to tomography and image enhancement

    International Nuclear Information System (INIS)

    Simpson, D.R.

    1981-01-01

    Recently, multi-pinhole gamma camera collimation has been introduced in the field of emission tomography. This collimation process simultaneously produces several images covering a limited angular range, which may then be recombined to obtain tomographic slices of the object imaged. This study has investigated a possible method for improving the images obtained by this technique by two multi-pinhole views taken 90 0 apart. During the course of this work, multi-pinhole collimation was also applied to in vivo imaging of the disintegration of tablets. Collimmators were designed and built both for tomography and imaging tablet disintegration, and computer programs were written to reconstruct the images by simple backprojection and by filtered backprojection. The use of multi-pinhole collimators to image the disintegration of tablets in vivo was clearly demonstrated. Phantom tests done in vitro were capable of imaging defects as small as 5 mm 2 , while images made with real tablets both in vitro and in vivo readily showed the onset and progress of the tablet disintegration. Further experiments are planned using this technique to measure gastric emptying times disintegration times of various tablet formulations. Limitations of multi-pinhole technique included problems such as limited ranges of viewing and artifacts introduced due to incomplete sampling

  19. Prediction of left main or 3-vessel disease using myocardial perfusion reserve on dynamic thallium-201 single-photon emission computed tomography with a semiconductor gamma camera.

    Science.gov (United States)

    Shiraishi, Shinya; Sakamoto, Fumi; Tsuda, Noriko; Yoshida, Morikatsu; Tomiguchi, Seiji; Utsunomiya, Daisuke; Ogawa, Hisao; Yamashita, Yasuyuki

    2015-01-01

    Myocardial perfusion imaging (MPI) may fail to detect balanced ischemia. We evaluated myocardial perfusion reserve (MPR) using Tl dynamic single-photon emission computed tomography (SPECT) and a novel cadmium zinc telluride (CZT) camera for predicting 3-vessel or left main coronary artery disease (CAD). METHODS AND RESULTS: A total of 55 consecutive patients with suspected CAD underwent SPECT-MPI and coronary angiography. The MPR index was calculated using the standard 2-compartment kinetic model. We analyzed the utility of MPR index, other SPECT findings, and various clinical variables. On multivariate analysis, MPR index and history of previous myocardial infarction (MI) predicted left main and 3-vessel disease. The area under the receiver operating characteristic curve was 0.81 for MPR index, 0.699 for history of previous MI, and 0.86 for MPR index plus history of previous MI. MPR index ≤1.5 yielded the highest diagnostic accuracy. Sensitivity, specificity, and accuracy were 86%, 78%, and 80%, respectively, for MPR index, 64%, 76%, 73% for previous MI, and 57%, 93%, and 84% for MPR index plus history of previous MI. Quantification of MPR using dynamic SPECT and a novel CZT camera may identify balanced ischemia in patients with left main or 3-vessel disease.

  20. Correction of dynamic time-activity curves for gamma-camera dead time, radiotracer delivery, and radioactive decay: special considerations with ultrashort-lived radioisotopes

    International Nuclear Information System (INIS)

    Kuruc, A.; Zimmerman, R.E.; Treves, S.

    1985-01-01

    Time-vs.-activity curves obtained by using ultrashort-lived radioisotopes often need to be corrected for the effects of gamma-camera dead time and physical decay. Count loss due to gamma-camera dead time can be monitored by using an electronic oscillator incorporated into the gamma camera. Two algorithms that use this information to correct time-activity curves are discussed. It is also shown that the effect of physical decay on a time-activity curve is dependent on the time course of delivery of the radioisotope to the organ of interest. A mathematical technique that corrects physical decay is described

  1. Assessment of right ventricular function with nonimaging first pass ventriculography and comparison of results with gamma camera studies.

    Science.gov (United States)

    Zhang, Z; Liu, X J; Liu, Y Z; Lu, P; Crawley, J C; Lahiri, A

    1990-08-01

    A new technique has been developed for measuring right ventricular function by nonimaging first pass ventriculography. The right ventricular ejection fraction (RVEF) obtained by non-imaging first pass ventriculography was compared with that obtained by gamma camera first pass and equilibrium ventriculography. The data has demonstrated that the correlation of RVEFs obtained by the nonimaging nuclear cardiac probe and by gamma camera first pass ventriculography in 15 subjects was comparable (r = 0.93). There was also a good correlation between RVEFs obtained by the nonimaging nuclear probe and by equilibrium gated blood pool studies in 33 subjects (r = 0.89). RVEF was significantly reduced in 15 patients with right ventricular and/or inferior myocardial infarction compared to normal subjects (28 +/- 9% v. 45 +/- 9%). The data suggests that nonimaging probes may be used for assessing right ventricular function accurately.

  2. Radiotracer study of wash load movement in a drum-type fabric washing machine using a gamma camera

    Energy Technology Data Exchange (ETDEWEB)

    Balt, A.P.; Brekel, L.D.M. van den; Vandecasteele, C.; Kolar, Z.

    1987-01-01

    A study was made of the movement of the wash loads in a drum-type washing machine. For this purpose a sup(99m)Tc source was attached to one or two separate textile pieces and the subsequent source positions were determined by means of a gamma-camera. The wash load movement pattern appears to depend on the type of textile material and its amount, as well as on the volume of water present in the washing machine.

  3. Radiotracer study of wash load movement in a drum-type fabric washing machine using a gamma camera

    International Nuclear Information System (INIS)

    Balt, A.P.; Brekel, L.D.M. van den; Vandecasteele, C.; Kolar, Z.

    1987-01-01

    A study was made of the movement of the wash loads in a drum-type washing machine. For this purpose a sup(99m)Tc source was attached to one or two separate textile pieces and the subsequent source positions were determined by means of a gamma-camera. The wash load movement pattern appears to depend on the type of textile material and its amount, as well as on the volume of water present in the washing machine. (author)

  4. A new method for elimination of artifacts produced by collimator septum effect in gamma-camera images

    International Nuclear Information System (INIS)

    Uchida, Isao; Onai, Yoshio; Tomaru, Teizo; Irifune, Toraji; Kakegawa, Makoto.

    1978-01-01

    Collimator artifacts may be present within the images produced by collimators whose septal width approaches the inherent resolution of the gamma-camera system. As the inherent resolution of the gamma-camera is improved, collimator artifacts become more prominent. The purpose of this study is to eliminate collimator artifacts from gamma-camera images. To eliminate the septum effect produced by high-energy parallel-hole collimators with thick septa, the following method was used: X and Y signals from the detector are made to ride on the triangular waves changing periodically, and resultant position signals obtained by this processing are applied to the corresponding deflection circuits in the CRT display. The oscillation amplitude of processed position signals can be regulated by the frequency and amplitude of the triangular waves. Regulation of the oscillation amplitude of position signals, which would produce maximum reduction of collimator artifacts, was to approach the spatial frequency responses of the overall processed line spread functions obtained experimentally to those of the Gaussian functions with FWHM equal to the geometric resolution calculated from the equation given by Gerber and Miller. In images of a pancreas phantom containing 131 I, collimator artifacts were clearly seen in the unprocessed case, but were eliminated in the processed case. (auth.)

  5. Feasibility of the gamma camera acceptance testing procedure introduced by the Swiss Federal Office of public health

    International Nuclear Information System (INIS)

    Baechler, S.; Bochud, F.; Verdun, F.R.; Corminboeuf, F.; Linder, R.; Trueb, Ph.; Malterre, J.; Bischof Delaloye, A.

    2006-01-01

    Like in the field of radiology, digital systems are also becoming the standard in the field of nuclear medicine. This offers not only the possibility to process, transmit and archive data from patients more easily but also to introduce quantitative measurements for quality controls. In this framework, standards concerning the qualification of gamma camera systems have been updated and appeared to be useful to set legal requirements, in spite of the fact, that this is not their goals. The aim of this study was first to choose a set of tests described in standards to define measurements to be performed at the acceptance of the systems and after the regular maintenance (at least once every six months). Reference values are then established to control the stability of the system. To verify the feasibility, from a technical and a time requirements points of view, the tests proposed for the quality assurance programme have been applied on three gamma camera systems. The results of this study show that new requirements concerning the quality assurance of gamma camera of the Swiss Federal Office of Public Health based on international standards required to slightly modify some procedures to reduce the time necessary for the acceptance and status tests. (authors)

  6. Development of an omnidirectional gamma-ray imaging Compton camera for low-radiation-level environmental monitoring

    Science.gov (United States)

    Watanabe, Takara; Enomoto, Ryoji; Muraishi, Hiroshi; Katagiri, Hideaki; Kagaya, Mika; Fukushi, Masahiro; Kano, Daisuke; Satoh, Wataru; Takeda, Tohoru; Tanaka, Manobu M.; Tanaka, Souichi; Uchida, Tomohisa; Wada, Kiyoto; Wakamatsu, Ryo

    2018-02-01

    We have developed an omnidirectional gamma-ray imaging Compton camera for environmental monitoring at low levels of radiation. The camera consisted of only six CsI(Tl) scintillator cubes of 3.5 cm, each of which was readout by super-bialkali photo-multiplier tubes (PMTs). Our camera enables the visualization of the position of gamma-ray sources in all directions (∼4π sr) over a wide energy range between 300 and 1400 keV. The angular resolution (σ) was found to be ∼11°, which was realized using an image-sharpening technique. A high detection efficiency of 18 cps/(µSv/h) for 511 keV (1.6 cps/MBq at 1 m) was achieved, indicating the capability of this camera to visualize hotspots in areas with low-radiation-level contamination from the order of µSv/h to natural background levels. Our proposed technique can be easily used as a low-radiation-level imaging monitor in radiation control areas, such as medical and accelerator facilities.

  7. 123I-amphetamine-SPECT in the diagnosis of neurological disorders

    International Nuclear Information System (INIS)

    Biersack, H.J.; Kreiten, K.; Hartmann, A.; Friedrich, G.; Linck, H.A.; Winkler, C.; Bonn Univ.; Rheinische Landesklinik, Bonn

    1985-01-01

    In contrast to conventional brain scintigraphy with sup(99m)Tc-pertechnetate, SPECT with 123 I-IMP enables visualization of the brain tissue itself. The relevance of this imaging technique was evaluated in 54 patients with cerebral disorders. SPECT of the brain was performed with a rotating gamma camera. In 6 of 24 epileptic patients, SPECT revealed foci consistent with EEG-findings which were, however, not detected by CCT. In 4 of 25 patients with cerebrovascular disease, hypoperfused areas were detected by SPECT despite negative results obtained with CCT. In 50% (10/20) of the patients with cerebrovascular disease, SPECT showed a greater functional extent of the lesions than CCT. In 3 patients with migraine and normal CCT, regional perfusion disturbancers were found. SPECT with 123 I-labeled amphetamines, therefore, enables diagnosis of functional perfusion disorders and metabolic disturbances that are not revealed by CCT. In addition, SPECT can be used to exactly demonstrate the functional extent of lesions detected by CCT. (orig.) [de

  8. /sup 123/I-amphetamine-SPECT in the diagnosis of neurological disorders

    Energy Technology Data Exchange (ETDEWEB)

    Biersack, H.J.; Kreiten, K.; Hartmann, A.; Friedrich, G.; Linck, H.A.; Winkler, C.

    1985-03-01

    In contrast to conventional brain scintigraphy with sup(99m)Tc-pertechnetate, SPECT with /sup 123/I-IMP enables visualization of the brain tissue itself. The relevance of this imaging technique was evaluated in 54 patients with cerebral disorders. SPECT of the brain was performed with a rotating gamma camera. In 6 of 24 epileptic patients, SPECT revealed foci consistent with EEG-findings which were, however, not detected by CCT. In 4 of 25 patients with cerebrovascular disease, hypoperfused areas were detected by SPECT despite negative results obtained with CCT. In 50% (10/20) of the patients with cerebrovascular disease, SPECT showed a greater functional extent of the lesions than CCT. In 3 patients with migraine and normal CCT, regional perfusion disturbancers were found. SPECT with /sup 123/I-labeled amphetamines, therefore, enables diagnosis of functional perfusion disorders and metabolic disturbances that are not revealed by CCT. In addition, SPECT can be used to exactly demonstrate the functional extent of lesions detected by CCT.

  9. Evaluation of efficiency of a semiconductor gamma camera eZ-SCOPE AN

    International Nuclear Information System (INIS)

    Wang Xinqiang; Wang Wei; Zhu Jiarui; Zhao Wenrui

    2004-01-01

    Objective: To study the basic performance of a compact semiconductor gamma camera (eZ-SCOPE AN) which is constructed using cadmium zinc telluride (CdZnTe) detectors with identical numbers of pixels. Each of the semiconductors sized 2 mm x 2 mm is located in 16 matrix x 16 matrix. The view field is 32 mm x 32 mm. Methods: Using a quality-control phantom, the eZ-SCOPE AN was evaluated. The specific performance characteristics were evaluated as shown below referring to National Electrical Manufacturers Association (NEMA) standards. 1) Intrinsic energy resolution. 2) Intrinsic count rate performance 3) Integral uniformity. 4) System planar sensitivity. 5) Special system resolution. Results: The intrinsic energy resolution [full width at half maximum (FWHM)] was 5.07%. It was failed to determine the maximal intrinsic count rate and the 20% count loss rate with a point source of 37 MBq because the plateau was not reached while using the solutions measured. The integral uniformity was 3.84% with the high sensitivity collimator. The system planer sensitivity was 20 988 counts·min -1 ·MBq -1 with high resolution collimator and 61 090 counts·min -1 ·MBq -1 with high sensitivity collimator. The special system resolution (FWHM) was 2.2 mm when the distance between the source and the collimator was 0 mm and it was 5.7 mm when the distance was 30 mm. Conclusion: This device is of high resolution and high sensitivity and is a reliable tool to investigate radioactivity biodistribution in small organs and small animals. (authors)

  10. Radionuclide examination of the cerebral circulation with the 'Fucks-Knipping Gamma-Camera'

    International Nuclear Information System (INIS)

    Arnim, W.H. von; Schicha, H.; Becker, V.; Vyska, K.; Feinendegen, L.E.

    1976-01-01

    In order to analyze cerebral blood flow for diagnostic purposes, Indium 113m-DTPA was i.v. injected into seated patients, and time-activity curves were registered by a multifacet gamma camera (Fucks-Knipping) form 8 regions of interest, from the median area and from the right and left side of the head: 3 from the hemisphere, 3 from the brain stem, 2 from the large arteries of the neck. The results from 14 patients with chronic impairment of cerebral blood flow were compared with normal data from 20 healthy individuals. The time activity curves were analyzed for peak-height, mean transit time, and ratio peak to plateau height. The individual parameters were investigated for the degree of their correlation in a multiparameter system. The results from the patients indicated for the different single parameters a non-uniform response. There was also no correlation between the deviation of different parameters, between single pathological parameters and the degree and the site of blood flow impairment. On the other hand, a positive correlation was found between the number of pathological parameters and the degree of blood flow impairment irrespective of the site of its localization. Reason for this result probably is the variable location and degree of blood flow compensation by collaterals, which predominantly are expected at the cerebral base. The data indicate the potential usefulness of the application of the multiparameter analysis to quantitatively detect the degree of impairment of cerebral blood flow without regard to its topography. In this respect, the method, here described, promises to be of clinical value for non-invasive and non-hazardous diagnostic screening of cerebral blood flow. (orig.) [de

  11. Monitoring system for isolated limb perfusion based on a portable gamma camera

    International Nuclear Information System (INIS)

    Orero, A.; Muxi, A.; Rubi, S.; Duch, J.; Vidal-Sicart, S.; Pons, F.; Roe, N.; Rull, R.; Pavon, N.; Pavia, J.

    2009-01-01

    Background: The treatment of malignant melanoma or sarcomas on a limb using extremity perfusion with tumour necrosis factor (TNF-α) and melphalan can result in a high degree of systemic toxicity if there is any leakage from the isolated blood territory of the limb into the systemic vascular territory. Leakage is currently controlled by using radiotracers and heavy external probes in a procedure that requires continuous manual calculations. The aim of this work was to develop a light, easily transportable system to monitor limb perfusion leakage by controlling systemic blood pool radioactivity with a portable gamma camera adapted for intraoperative use as an external probe, and to initiate its application in the treatment of MM patients. Methods: A special collimator was built for maximal sensitivity. Software for acquisition and data processing in real time was developed. After testing the adequacy of the system, it was used to monitor limb perfusion leakage in 16 patients with malignant melanoma to be treated with perfusion of TNF-α and melphalan. Results: The field of view of the detector system was 13.8 cm, which is appropriate for the monitoring, since the area to be controlled was the precordial zone. The sensitivity of the system was 257 cps/MBq. When the percentage of leakage reaches 10% the associated absolute error is ±1%. After a mean follow-up period of 12 months, no patients have shown any significant or lasting side-effects. Partial or complete remission of lesions was seen in 9 out of 16 patients (56%) after HILP with TNF-α and melphalan. Conclusion: The detector system together with specially developed software provides a suitable automatic continuous monitoring system of any leakage that may occur during limb perfusion. This technique has been successfully implemented in patients for whom perfusion with TNF-α and melphalan has been indicated. (orig.)

  12. Monitoring system for isolated limb perfusion based on a portable gamma camera

    Energy Technology Data Exchange (ETDEWEB)

    Orero, A.; Muxi, A.; Rubi, S.; Duch, J. [Servei de Medicina Nuclear, Hospital Clinic, Barcelona (Spain); Vidal-Sicart, S.; Pons, F. [Servei de Medicina Nuclear, Hospital Clinic, Barcelona (Spain); Inst. d' Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Barcelona (Spain); Red Tematica de Investigacion Cooperativa en Cancer (RTICC), Barcelona (Spain); Roe, N. [Servei de Medicina Nuclear, Hospital Clinic, Barcelona (Spain); CIBER de Bioingenieria, Biomateriales y Nanomedicina (CIBER-BBN), Barcelona (Spain); Rull, R. [Servei de Cirurgia, Hospital Clinic, Barcelona (Spain); Pavon, N. [Inst. de Fisica Corpuscular, CSIC - UV, Valencia (Spain); Pavia, J. [Servei de Medicina Nuclear, Hospital Clinic, Barcelona (Spain); Inst. d' Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Barcelona (Spain); CIBER de Bioingenieria, Biomateriales y Nanomedicina (CIBER-BBN), Barcelona (Spain)

    2009-07-01

    Background: The treatment of malignant melanoma or sarcomas on a limb using extremity perfusion with tumour necrosis factor (TNF-{alpha}) and melphalan can result in a high degree of systemic toxicity if there is any leakage from the isolated blood territory of the limb into the systemic vascular territory. Leakage is currently controlled by using radiotracers and heavy external probes in a procedure that requires continuous manual calculations. The aim of this work was to develop a light, easily transportable system to monitor limb perfusion leakage by controlling systemic blood pool radioactivity with a portable gamma camera adapted for intraoperative use as an external probe, and to initiate its application in the treatment of MM patients. Methods: A special collimator was built for maximal sensitivity. Software for acquisition and data processing in real time was developed. After testing the adequacy of the system, it was used to monitor limb perfusion leakage in 16 patients with malignant melanoma to be treated with perfusion of TNF-{alpha} and melphalan. Results: The field of view of the detector system was 13.8 cm, which is appropriate for the monitoring, since the area to be controlled was the precordial zone. The sensitivity of the system was 257 cps/MBq. When the percentage of leakage reaches 10% the associated absolute error is {+-}1%. After a mean follow-up period of 12 months, no patients have shown any significant or lasting side-effects. Partial or complete remission of lesions was seen in 9 out of 16 patients (56%) after HILP with TNF-{alpha} and melphalan. Conclusion: The detector system together with specially developed software provides a suitable automatic continuous monitoring system of any leakage that may occur during limb perfusion. This technique has been successfully implemented in patients for whom perfusion with TNF-{alpha} and melphalan has been indicated. (orig.)

  13. Performance assessment of a slat gamma camera collimator for 511 keV imaging. Corrigendum. Phys. Med. Biol., v. 44, p. 1735-1741

    International Nuclear Information System (INIS)

    Britten, A.J.; Klie, R.

    1999-01-01

    Further to the recent work on slat gamma camera collimators by Britten and Klie (see above), the authors would like to add some references on the early work in gamma camera slat collimators, which should have been included for completeness. These papers are the original publication by Keyes (1975), and the work carried out by Webb et al (1992, 1993) deriving equations for geometric sensitivity and showing Monte Carlo modelling of performance. (author)

  14. Breast-specific gamma-imaging: molecular imaging of the breast using 99mTc-sestamibi and a small-field-of-view gamma-camera.

    Science.gov (United States)

    Jones, Elizabeth A; Phan, Trinh D; Blanchard, Deborah A; Miley, Abbe

    2009-12-01

    Breast-specific gamma-imaging (BSGI), also known as molecular breast imaging, is breast scintigraphy using a small-field-of-view gamma-camera and (99m)Tc-sestamibi. There are many different types of breast cancer, and many have characteristics making them challenging to detect by mammography and ultrasound. BSGI is a cost-effective, highly sensitive and specific technique that complements other imaging modalities currently being used to identify malignant lesions in the breast. Using the current Society of Nuclear Medicine guidelines for breast scintigraphy, Legacy Good Samaritan Hospital began conducting BSGI, breast scintigraphy with a breast-optimized gamma-camera. In our experience, optimal imaging has been conducted in the Breast Center by a nuclear medicine technologist. In addition, the breast radiologists read the BSGI images in correlation with the mammograms, ultrasounds, and other imaging studies performed. By modifying the current Society of Nuclear Medicine protocol to adapt it to the practice of breast scintigraphy with these new systems and by providing image interpretation in conjunction with the other breast imaging studies, our center has found BSGI to be a valuable adjunctive procedure in the diagnosis of breast cancer. The development of a small-field-of-view gamma-camera, designed to optimize breast imaging, has resulted in improved detection capabilities, particularly for lesions less than 1 cm. Our experience with this procedure has proven to aid in the clinical work-up of many of our breast patients. After reading this article, the reader should understand the history of breast scintigraphy, the pharmaceutical used, patient preparation and positioning, imaging protocol guidelines, clinical indications, and the role of breast scintigraphy in breast cancer diagnosis.

  15. Gamma-camera 18F-FDG PET in diagnosis and staging of patients presenting with suspected lung cancer and comparison with dedicated PET

    DEFF Research Database (Denmark)

    Oturai, Peter S; Mortensen, Jann; Enevoldsen, Henriette

    2004-01-01

    It is not clear whether high-quality coincidence gamma-PET (gPET) cameras can provide clinical data comparable with data obtained with dedicated PET (dPET) cameras in the primary diagnostic work-up of patients with suspected lung cancer. This study focuses on 2 main issues: direct comparison...

  16. Pre-clinical and Clinical Evaluation of High Resolution, Mobile Gamma Camera and Positron Imaging Devices

    Science.gov (United States)

    2010-10-01

    Downloaded on February 20,2010 at 10:55:59 EST from IEEE Xplore . Restrictions apply. STUDENSKI et al.: ACQUISITION AND PROCESSING METHODS FOR A BEDSIDE...February 20,2010 at 10:55:59 EST from IEEE Xplore . Restrictions apply. 208 IEEE TRANSACTIONS ON NUCLEAR SCIENCE, VOL. 57, NO. 1, FEBRUARY 2010 from the...59 EST from IEEE Xplore . Restrictions apply. STUDENSKI et al.: ACQUISITION AND PROCESSING METHODS FOR A BEDSIDE CARDIAC SPECT IMAGING SYSTEM 209

  17. Depth-of-Interaction Compensation Using a Focused-Cut Scintillator for a Pinhole Gamma Camera

    OpenAIRE

    Alhassen, Fares; Kudrolli, Haris; Singh, Bipin; Kim, Sangtaek; Seo, Youngho; Gould, Robert G.; Nagarkar, Vivek V.

    2011-01-01

    Preclinical SPECT offers a powerful means to understand the molecular pathways of drug interactions in animal models by discovering and testing new pharmaceuticals and therapies for potential clinical applications. A combination of high spatial resolution and sensitivity are required in order to map radiotracer uptake within small animals. Pinhole collimators have been investigated, as they offer high resolution by means of image magnification. One of the limitations of pinhole geometries is ...

  18. Software for dosimetry hypothyroid patients treated with I131 pick up and using probe gamma camera

    International Nuclear Information System (INIS)

    Jimenez Felstrom, D.; Luis simon, J.; Reyes Garcia, R.; Derecho Torres, P.; Herrador Cordoba, M.

    2015-01-01

    In this communication the process recently implemented in our hospital for pre and post treatment of patients treated with I-131 in benign diseases of the thyroid gland internal dosimetry is described. We have developed a proprietary software that facilitates the process of dosimetry. Through scans Planar or pictures Spect be determines the mass of the gland thyroid. In function of the mass, is calculated by Monte Carlo the media power absorbed by disintegration of the I-131 in said gland endocrine. (Author)

  19. Development of a tomographic system adapted to 3D measurement of contaminated wounds based on the Cacao concept (Computer aided collimation Gamma Camera); Developpement a partir du concept CACAO (Camera A Collimation Assistee par Ordinateur) d'un systeme tomographique adapte a la mesure 3D de plaies contaminees

    Energy Technology Data Exchange (ETDEWEB)

    Douiri, A

    2002-03-01

    The computer aided collimation gamma camera (CACAO in French) is a gamma camera using a collimator with large holes, a supplementary linear scanning motion during the acquisition and a dedicated reconstruction program taking full account of the source depth. The CACAO system was introduced to improve both the sensitivity and the resolution in nuclear medicine. This thesis focuses on the design of a fast and robust reconstruction algorithm in the CACAO project. We start by an overview of tomographic imaging techniques in nuclear medicine. After modelling the physical CACAO system, we present the complete reconstruction program which involves three steps: 1) shift and sum 2) deconvolution and filtering 3) rotation and sum. The deconvolution is the critical step that decreases the signal to noise ratio of the reconstructed images. We propose a regularized multi-channel algorithm to solve the deconvolution problem. We also present a fast algorithm based on Splines functions and preserving the high quality of the reconstructed images for the shift and the rotation steps. Comparisons of simulated reconstructed images in 2D and 3D for the conventional system (CPHC) and CACAO demonstrate the ability of CACAO system to increase the quality of the SPECT images. Finally, this study concludes with an experimental approach with a pixellated detector conceived for a 3D measurement of contaminated wounds. This experimentation proves the possible advantages of coupling the CACAO project with pixellated detectors. Moreover, a variety of applications could fully benefit from the CACAO system, such as low activity imaging, the use of high-energy gamma isotopes and the visualization of deep organs. Moreover the combination of the CACAO system with a pixels detector may open up further possibilities for the future of nuclear medicine. (author)

  20. Measurement of prompt gamma profiles in inhomogeneous targets with a knife-edge slit camera during proton irradiation

    International Nuclear Information System (INIS)

    Priegnitz, M; Helmbrecht, S; Fiedler, F; Janssens, G; Smeets, J; Vander Stappen, F; Perali, I; Sterpin, E

    2015-01-01

    Proton and ion beam therapies become increasingly relevant in radiation therapy. To fully exploit the potential of this irradiation technique and to achieve maximum target volume conformality, the verification of particle ranges is highly desirable. Many research activities focus on the measurement of the spatial distributions of prompt gamma rays emitted during irradiation. A passively collimating knife-edge slit camera is a promising option to perform such measurements. In former publications, the feasibility of accurate detection of proton range shifts in homogeneous targets could be shown with such a camera. We present slit camera measurements of prompt gamma depth profiles in inhomogeneous targets. From real treatment plans and their underlying CTs, representative beam paths are selected and assembled as one-dimensional inhomogeneous targets built from tissue equivalent materials. These phantoms have been irradiated with monoenergetic proton pencil beams. The accuracy of range deviation estimation as well as the detectability of range shifts is investigated in different scenarios. In most cases, range deviations can be detected within less than 2 mm. In close vicinity to low-density regions, range detection is challenging. In particular, a minimum beam penetration depth of 7 mm beyond a cavity is required for reliable detection of a cavity filling with the present setup. Dedicated data post-processing methods may be capable of overcoming this limitation. (paper)

  1. Single photon emission computerized tomography (SPECT)

    International Nuclear Information System (INIS)

    Ganatra, R.D.

    1992-01-01

    Tomography in nuclear medicine did not originate after the introduction of X-ray computerized tomography (CT). Even in the days of rectilinear scanner, tomography was attempted with multiple detector heads rotating around the patient, but the counts at each plane were never very high to obtain a satisfactory image. A high resolution focusing collimator can look at different depths but taking several slices in one projection was a time consuming process. Rectilinear scanners lose lot of counts in the collimator to look at one point, at on time, in one plane. It is true that attempts to do tomography with gamma camera really got a boost after the success of CT. By that time, algorithms for doing reconstruction of images also were highly refined and for advanced. Clinical application of SPECT has become widespread now, because of the development of suitable radiopharmaceuticals and improvement in instrumentation. The SPECT provides a direct measure of regional organ function and is performed with nuclides such as 123 I and 99 Tc m that emit a mono-image photon during their decay. SPECT is far less expensive than positron emission tomography

  2. Single photon emission computerized tomography (SPECT)

    Energy Technology Data Exchange (ETDEWEB)

    Ganatra, R D

    1993-12-31

    Tomography in nuclear medicine did not originate after the introduction of X-ray computerized tomography (CT). Even in the days of rectilinear scanner, tomography was attempted with multiple detector heads rotating around the patient, but the counts at each plane were never very high to obtain a satisfactory image. A high resolution focusing collimator can look at different depths but taking several slices in one projection was a time consuming process. Rectilinear scanners lose lot of counts in the collimator to look at one point, at on time, in one plane. It is true that attempts to do tomography with gamma camera really got a boost after the success of CT. By that time, algorithms for doing reconstruction of images also were highly refined and for advanced. Clinical application of SPECT has become widespread now, because of the development of suitable radiopharmaceuticals and improvement in instrumentation. The SPECT provides a direct measure of regional organ function and is performed with nuclides such as {sup 123}I and {sup 99}Tc{sup m} that emit a mono-image photon during their decay. SPECT is far less expensive than positron emission tomography

  3. Implementation of test for quality assurance in nuclear medicine gamma camera

    Science.gov (United States)

    Moreno, A. Montoya; Laguna, A. Rodríguez; Zamudio, Flavio E. Trujillo

    2012-10-01

    In nuclear medicine (NM) over 90% of procedures are performed for diagnostic purposes. To ensure adequate diagnostic quality of images and the optimization of the doses received by patients originated from the radioactive material is essential for regular monitoring and equipment performance through a quality assurance program (QAP). The QAP consists of 15 proposed performance tomographic and not tomographic gamma camera (GC) tests, and is based on recommendations of international organizations. We describe some results of the performance parameters of QAP applied to a GC model e.cam Siemens, of the Department of NM of the National Cancer Institute of Mexico (INCan). The results were: (1) The average intrinsic spatial resolution (Rin) was 4.67 ± 0.25 mm at the limit of acceptance criterion of 4.4 mm. (2) The sensitivity extrinsic (Sext), with maximum variations of 1.8% (less than 2% which is the criterion of acceptance). (3) Rotational Uniformity (Urot), with values of integral uniformity (IU) in the useful field of view detector (UFOV), with maximum percentage change of 0.97% and monthly variations equal angles, ranging from 0.13 to 0.99% less than 1%. (4) The displacement of the center of rotation (DCOR), indicated a maximum deviation of 0.155 ± 0.039 mm less than 4.795 mm, an absolute deviation of less than 0.5 where pixel 0.085 pixel is suggested, the criteria are assigned to low-energy collimator high resolution. (5) In tomographic uniformity (Utomo), UI values (%) and percentage noise level (rms%) were 7.54 ± 1.53 and 4.18 ± 1.69 which are consistent with the limits of acceptance of 7.0-12.0% and 3.0-6.0% respectively. The smallest cold sphere has a diameter of 11.4 mm. The implementation of a QAP allows for high quality diagnostic images, optimization of the doses given to patients, a reduction of exposure to occupationally exposed workers (POE, by its Spanish acronym), and generally improves the productivity of the service. This proposal can be used to

  4. Dual-head gamma camera system for intraoperative localization of radioactive seeds

    International Nuclear Information System (INIS)

    Arsenali, B; Viergever, M A; Gilhuijs, K G A; De Jong, H W A M; Beijst, C; Dickerscheid, D B M

    2015-01-01

    Breast-conserving surgery is a standard option for the treatment of patients with early-stage breast cancer. This form of surgery may result in incomplete excision of the tumor. Iodine-125 labeled titanium seeds are currently used in clinical practice to reduce the number of incomplete excisions. It seems likely that the number of incomplete excisions can be reduced even further if intraoperative information about the location of the radioactive seed is combined with preoperative information about the extent of the tumor. This can be combined if the location of the radioactive seed is established in a world coordinate system that can be linked to the (preoperative) image coordinate system. With this in mind, we propose a radioactive seed localization system which is composed of two static ceiling-suspended gamma camera heads and two parallel-hole collimators. Physical experiments and computer simulations which mimic realistic clinical situations were performed to estimate the localization accuracy (defined as trueness and precision) of the proposed system with respect to collimator-source distance (ranging between 50 cm and 100 cm) and imaging time (ranging between 1 s and 10 s). The goal of the study was to determine whether or not a trueness of 5 mm can be achieved if a collimator-source distance of 50 cm and imaging time of 5 s are used (these specifications were defined by a group of dedicated breast cancer surgeons). The results from the experiments indicate that the location of the radioactive seed can be established with an accuracy of 1.6 mm  ±  0.6 mm if a collimator-source distance of 50 cm and imaging time of 5 s are used (these experiments were performed with a 4.5 cm thick block phantom). Furthermore, the results from the simulations indicate that a trueness of 3.2 mm or less can be achieved if a collimator-source distance of 50 cm and imaging time of 5 s are used (this trueness was achieved for all 14 breast phantoms which

  5. Breast Imaging Utilizing Dedicated Gamma Camera and (99m)Tc-MIBI: Experience at the Tel Aviv Medical Center and Review of the Literature Breast Imaging.

    Science.gov (United States)

    Even-Sapir, Einat; Golan, Orit; Menes, Tehillah; Weinstein, Yuliana; Lerman, Hedva

    2016-07-01

    The scope of the current article is the clinical role of gamma cameras dedicated for breast imaging and (99m)Tc-MIBI tumor-seeking tracer, as both a screening modality among a healthy population and as a diagnostic modality in patients with breast cancer. Such cameras are now commercially available. The technology utilizing a camera composed of a NaI (Tl) detector is termed breast-specific gamma imaging. The technology of dual-headed camera composed of semiconductor cadmium zinc telluride detectors that directly converts gamma-ray energy into electronic signals is termed molecular breast imaging. Molecular breast imaging system has been installed at the Department of Nuclear medicine at the Tel Aviv Sourasky Medical Center, Tel Aviv in 2009. The article reviews the literature well as our own experience. Copyright © 2016 Elsevier Inc. All rights reserved.

  6. Optimisation of a dual head semiconductor Compton camera using Geant4

    Energy Technology Data Exchange (ETDEWEB)

    Harkness, L.J. [Department of Physics, University of Liverpool, Oliver Lodge Laboratory, Liverpool L697ZE (United Kingdom)], E-mail: ljh@ns.ph.liv.ac.uk; Boston, A.J.; Boston, H.C.; Cooper, R.J.; Cresswell, J.R.; Grint, A.N.; Nolan, P.J.; Oxley, D.C.; Scraggs, D.P. [Department of Physics, University of Liverpool, Oliver Lodge Laboratory, Liverpool L697ZE (United Kingdom); Beveridge, T.; Gillam, J. [School of Physics and Materials Engineering, Monash University, Melbourne (Australia); Lazarus, I. [STFC Daresbury Laboratory, Warrington, Cheshire (United Kingdom)

    2009-06-01

    Conventional medical gamma-ray camera systems utilise mechanical collimation to provide information on the position of an incident gamma-ray photon. Systems that use electronic collimation utilising Compton image reconstruction techniques have the potential to offer huge improvements in sensitivity. Position sensitive high purity germanium (HPGe) detector systems are being evaluated as part of a single photon emission computed tomography (SPECT) Compton camera system. Data have been acquired from the orthogonally segmented planar SmartPET detectors, operated in Compton camera mode. The minimum gamma-ray energy which can be imaged by the current system in Compton camera configuration is 244 keV due to the 20 mm thickness of the first scatter detector which causes large gamma-ray absorption. A simulation package for the optimisation of a new semiconductor Compton camera has been developed using the Geant4 toolkit. This paper will show results of preliminary analysis of the validated Geant4 simulation for gamma-ray energies of SPECT, 141 keV.

  7. Regional cerebral blood flow measurement using N-isopropyl-p-[123I] iodoamphetamine and rotating gamma camera emission computed tomography

    International Nuclear Information System (INIS)

    Matsuda, Hiroshi; Seki, Hiroyasu; Ishida, Hiroko

    1985-01-01

    Thirty-one regional cerebral blood flow (rCBF) measurements were performed on 26 patients with cerebrovascular accidents using N-Isopropyl-p-[ 123 I] Iodoamphetamine ( 123 I-IMP) and rotating gamma camera emission computed tomography (ECT). The equation for determining rCBF is as follows: F=100.R.Cb/(N.A), where F is rCBF in ml/100 g/min., R is the constant withdrawal rate of arterial blood in ml/min., Cb is the brain activity concentration in μCi/g, A is the total activity (5 min.) in the withdrawal arterial whole blood in μCi and N is the fraction of A that is true tracer activity (0.75). In determining Cb at 5 min. after injection, reconstructed counts from 35 min. to 59 min. were corrected to represent those from 4 min. to 5 min. with the use of time activity curve for the entire brain immediately after injection to 30 min. Reconstructed counts of central region in tomographic image were corrected 118% of the obtained values from the result of the countingrate ratio between peripheral and central regions of interests obtained from phantom study. Brain mean blood flow values were distributed from 11 to 39 ml/100 g/min. In 119 cortical regions obtained from 11 measurements in 9 patients, there was a significant correlation (r=0.41, p 123 I-IMP and rotating gamma camera ECT and those from 133 Xe inhalation method. rCBF measurement using 123 I-IMP and rotating gamma camera ECT is not only relatively noninvasive measurement for the entire brain but also three-dimensional evaluation. Besides, it is superior in spatial resolution and accuracy to conventional 133 Xe clearance method. (author)

  8. Clinical significance of I-123 IMP brain SPECT in children with brain diseases

    International Nuclear Information System (INIS)

    Takishima, Teruo; Machida, Kikuo; Honda, Norinari; Mamiya, Toshio; Takahashi, Taku; Kamano, Tsuyoshi; Hasegawa, Noriko

    1990-01-01

    Single photon emission computed tomography (SPECT) of the brain using N-isopropyl p-I-123-iodoamphetamine (I-123 IMP) was performed in 43 children with suspected brain diseases. Forty-three children (25 males and 18 females), with an age range of 24 days-15 years (mean: 6.6 years), were included in the study. Six patients were subsequently diagnosed as normal. Early SPECT of the brain was performed 30 minutes after intravenous administration of 74-111 MBq (2-3 mCi) I-123 IMP using a rotating gamma camera equipped with a 30-degree slant hole and medium energy collimator. Transverse images were reconstructed by Shepp-Logan filtered back projection method with attenuation correction after spatial filtering using an 8th order Butterworth-Wiener filter. Findings of I-123 IMP SPECT were compared with those of X-ray computed tomography (CT) and electroencephalography (EEG). The results showed that in I-123 IMP SPECT, abnormality was found in 30 out of 37 children with brain diseases. The incidence of abnormal findings in the 37 patients was 81% in I-123 IMP SPECT, 61% in X-ray CT, and 78% in EEG; in both cryptogenic and secondary epilepsy, the incidence of abnormality was higher in I-123 IMP SPECT than in X-ray CT. (70% and 94% vs 50% and 81% respectively), and epileptic foci detected by EEG did not correspond with defects found using I-123 IMP SPECT in 27% of the patients; and in asphyxiated infants, a high incidence of abnormality was observed on both I-123 IMP SPECT (86%) and X-ray CT (86%). In conclusion, I-123 IMP SPECT is a clinically useful examination in children with brain disease. (author)

  9. Uteroplacental blood flow in diabetic pregnancy: measurements with indium 113m and a computer-linked gamma camera

    International Nuclear Information System (INIS)

    Nylund, L.; Lunell, N.O.; Lewander, R.; Persson, B.; Sarby, B.

    1982-01-01

    The uteroplacental blood flow index in the last trimester of pregnancy in 26 women with diabetes mellitus was compared to that in 41 healthy control subjects. After an intravenous injection of 1 mCi of indium 113m, the radiation over the placenta was recorded with a computer-linked gamma camera. From time-activity analysis of the isotope accumulation curve, a uteroplacental blood flow index could be calculated. In the diabetic pregnant women, the maternal-placental blood flow index was reduced 35% to 45% compared to that in healthy women. The blood flow index tended to be further impaired in those diabetic women who had higher blood glucose values

  10. Patient position matching between SPECT and CT

    International Nuclear Information System (INIS)

    Eubig, C.; Lodhi, L.M.; Trueblood, J.H.; Kingsbury, T.; Burke, G.; Flickenger, F.

    1990-01-01

    Since the authors had previously developed an ability for accurate repositioning of patients by means of video imaging of their external features, it was their purpose to determine if separate video systems placed in SPECT and CT rooms could be positioned and a calibration procedure for each modality developed to assure easy identification and acquisition of corresponding congruent axial image sections through the patient. A video frame grabber is used to acquire an image of the patient in one room and superimpose it on a similar image of the patient in the other room. A radioactive ruler visible at CT images obtained with a gamma camera computer, and a CT scout image are used to adjust the initial relative position of the video cameras and calibrate the acquisition parameters of both systems. The success of this alignment procedure was tested with a body phantom. The body phantom studies indicate that this method of positioning the patient and acquiring corresponding aligned CT and SPECT axial sections can be successful where internal organ shift between the acquisitions is minimal. This should lead to a reduction of the time and computer resources necessary to fuse or superimpose images of corresponding patient sections acquired with different modalities

  11. Wireless Synchronization of a Multi-Pinhole Small Animal SPECT Collimation Device With a Clinical Scanner

    Science.gov (United States)

    DiFilippo, Frank P.; Patel, Sagar

    2009-06-01

    A multi-pinhole collimation device for small animal single photon emission computed tomography (SPECT) uses the gamma camera detectors of a standard clinical SPECT scanner. The collimator and animal bed move independently of the detectors, and therefore their motions must be synchronized. One approach is manual triggering of the SPECT acquisition simultaneously with a programmed motion sequence for the device. However, some data blurring and loss of image quality result, and true electronic synchronization is preferred. An off-the-shelf digital gyroscope with integrated Bluetooth interface provides a wireless solution to device synchronization. The sensor attaches to the SPECT gantry and reports its rotational speed to a notebook computer controlling the device. Software processes the rotation data in real-time, averaging the signal and issuing triggers while compensating for baseline drift. Motion commands are sent to the collimation device with minimal delay, within approximately 0.5 second of the start of SPECT gantry rotation. Test scans of a point source demonstrate an increase in true counts and a reduction in background counts compared to manual synchronization. The wireless rotation sensor provides robust synchronization of the collimation device with the clinical SPECT scanner and enhances image quality.

  12. Quality control of analogue to digital conversion circuitry for artefact-free SPECT imaging

    International Nuclear Information System (INIS)

    Gillen, G.J.; Elliott, A.T.

    1992-01-01

    A simple method for the objective, quantitative assessment of analogue to digital conversion (ADC) differential linearity has been developed for SPECT imaging. The analytical approach uses the fact that a differential non-linearity in the ADC will produce a non-uniformity in the digitized image which has a well defined periodicity. This can be most clearly demonstrated in the frequency space domain by determining the Fourier transform of a thick profile which is taken through the centre of a flood field image. The accuracy of the method permits deteriorations in the performance of ADCs to be detected well before significant reductions in SPECT image quality are produced. The availability of a quantitative measure of ADC performance, which can be tested objectively using a simple data acquisition method, is of value in the specification, acceptance testing and general quality control of gamma camera SPECT systems. (author)

  13. Thyroid mass estimation in Grave's disease by SPECT

    International Nuclear Information System (INIS)

    Pant, G.S.; Sharma, S.K.; Kumar, R.; Pandey, A.K.; Gupta, A.K.

    2002-01-01

    of 0.99 was found in this study. We feel that the technique may also be used for different thyroid shapes with proper standardisation using SPECT. The improved image quality with modern gamma cameras and available tools for selecting threshold and measurement of volume by SPECT method may be adequate for dosimetry

  14. Calibration of gamma cameras for the evaluation of accidental intakes of high-energy photon emitting radionuclides by humans based on urine samples

    Energy Technology Data Exchange (ETDEWEB)

    Degenhardt, A.L.; Lucena, E.A.; Reis, A.A. dos; Souza, W.O.; Dantas, A.L.A.; Dantas, B.M., E-mail: bmdantas@ird.gov.br [Instituto de Radioproteção e Dosimetria (IRD/CNEN-RJ), Rio de Janeiro, RJ (Brazil). Div. de Dosimetria

    2017-07-01

    The prompt response to emergency situations involving suspicion of intakes of radionuclides requires the use of simple and rapid methods of internal monitoring of the exposed individuals. The use of gamma cameras to estimate intakes and committed doses was investigated by the Centers for Disease Control and Preventions (CDC) of the USA in 2010.The present study aims to develop a calibration protocol for gamma cameras to be applied on internal monitoring based on urine samples to evaluate the incorporation of high-energy photon emitting radionuclides in emergency situations. A gamma camera available in a public hospital located in the city of Rio de Janeiro was calibrated using a standard liquid source of {sup 152}Eu supplied by the LNMRI of the IRD.'Efficiency vs Energy' curves at 10 and 30 cm were obtained. Calibration factors, Minimum Detectable Activities and Minimum Detectable Effective Doses of the gamma camera were calculated for {sup 137}Cs and {sup 60}Co. The gamma camera evaluated in this work presents enough sensitivity to detect activities of such radionuclides at dose levels suitable to assess suspected accidental intakes. (author)

  15. Nuclear myocardial perfusion imaging using thallium-201 with a novel multifocal collimator SPECT/CT: IQ-SPECT versus conventional protocols in normal subjects.

    Science.gov (United States)

    Matsuo, Shinro; Nakajima, Kenichi; Onoguchi, Masahisa; Wakabayash, Hiroshi; Okuda, Koichi; Kinuya, Seigo

    2015-06-01

    A novel multifocal collimator, IQ-SPECT (Siemens) consists of SMARTZOOM, cardio-centric and 3D iterative SPECT reconstruction and makes it possible to perform MPI scans in a short time. The aims are to delineate the normal uptake in thallium-201 ((201)Tl) SPECT in each acquisition method and to compare the distribution between new and conventional protocol, especially in patients with normal imaging. Forty patients (eight women, mean age of 75 years) who underwent myocardial perfusion imaging were included in the study. All patients underwent one-day protocol perfusion scan after an adenosine-stress test and at rest after administering (201)Tl and showed normal results. Acquisition was performed on a Symbia T6 equipped with a conventional dual-headed gamma camera system (Siemens ECAM) and with a multifocal SMARTZOOM collimator. Imaging was performed with a conventional system followed by IQ-SPECT/computed tomography (CT). Reconstruction was performed with or without X-ray CT-derived attenuation correction (AC). Two nuclear physicians blinded to clinical information interpreted all myocardial perfusion images. A semi-quantitative myocardial perfusion was analyzed by a 17-segment model with a 5-point visual scoring. The uptake of each segment was measured and left ventricular functions were analyzed by QPS software. IQ-SPECT provided good or excellent image quality. The quality of IQ-SPECT images without AC was similar to those of conventional LEHR study. Mid-inferior defect score (0.3 ± 0.5) in the conventional LEHR study was increased significantly in IQ-SPECT with AC (0 ± 0). IQ-SPECT with AC improved the mid-inferior decreased perfusion shown in conventional images. The apical tracer count in IQ-SPECT with AC was decreased compared to that in LEHR (0.1 ± 0.3 vs. 0.5 ± 0.7, p IQ-SPECT was significantly higher than that from the LEHR collimator (p = 0.0009). The images of IQ-SPECT acquired in a short time are equivalent to that of conventional LEHR

  16. Use of dual-head gamma camera in radionuclide internal contamination monitoring on radiation workers from a nuclear medicine department

    International Nuclear Information System (INIS)

    Rodriguez-Laguna, A.; Brandan, M.E.

    2008-01-01

    As a part of an internal dosimetry program that is performed at the Mexican National Institute of Cancerology - Nuclear Medicine Department, in the present work we suggest a procedure for the routinely monitoring of internal contamination on radiation workers and nuclear medicine staff. The procedure is based on the identification and quantification of contaminating radionuclides in human body by using a dual-head whole-body gamma camera. The results have shown that the procedures described in this study can be used to implement a method to quantify minimal accumulated activity in the main human organs to evaluate internal contamination with radionuclides. The high sensitivity of the uncollimated gamma camera is advantageous for the routinely detection and identification of small activities of internal contamination. But, the null spatial resolution makes impossible the definition of contaminated region of interest. Then, the use of collimators is necessary to the quantification of incorporated radionuclides activities in the main human organs and for the internal doses assessment. (author)

  17. Multimodality imaging: transfer and fusion of SPECT and MRI data

    International Nuclear Information System (INIS)

    Knesaurek, K.

    1994-01-01

    Image fusion is a technique which offers the best of both worlds. It unites the two basic types of medical images: functional body images(PET or SPECT scans), which provide physiological information, and structural images (CT or MRI), which provide an anatomic map of the body. Control-point based registration technique was developed and used. Tc-99m point sources were used as external markers in SPECT studies while, for MRI and CT imaging only anatomic landmarks were used as a control points. The MRI images were acquired on GE Signa 1.2 system and CT data on a GE 9800 scanner. SPECT studies were performed 1h after intravenous injection of the 740 MBq of the Tc-99m-HMPAO on the triple-headed TRIONIX gamma camera. B-spline and bilinear interpolation were used for the rotation, scaling and translation of the images. In the process of creation of a single composite image, in order to retain information from the individual images, MRI (or CT) image was scaled to one color range and a SPECT image to another. In some situations the MRI image was kept black-and-white while the SPECT image was pasted on top of it in 'opaque' mode. Most errors which propagate through the matching process are due to sample size, imperfection of the acquisition system, noise and interpolations used. Accuracy of the registration was investigated by SPECT-CT study performed on a phantom study. The results has shown that accuracy of the matching process is better, or at worse, equal to 2 mm. (author)

  18. Problems involved in quantitative gamma camera scintigraphy. C. Sensitivity and homogeneity

    International Nuclear Information System (INIS)

    Erbsmann, F.; Paternot, J.; Piepsz, A.; Dobbeleire, A.; Froideville, J.L.

    1976-01-01

    A constant sensitivity of the scintillation camera is an important feature of quantitative digital scintigraphy and must be controlled as much as other factors. The phantom distribution is an excellent test of the camera adjusment but according to present knowledge cannot be used to make corrections of any kind. The best way to reduce the effect of spatial sensitivity variations is to use the same part of the detector constantly to measure the standard as well as the two successive kidneys. Users who wish to measure the uptake of both kidneys simultaneously are advised to measure the standard in the approximate position of the two kidneys and to check that the count rate difference is not more than 5% for example, a higher value requiring a camera adjustment [fr

  19. Regional cerebral blood flow in SPECT pattern in Parkinson's disease

    International Nuclear Information System (INIS)

    Lenart-Jankowska, D.; Junik, R.; Sowinski, J.; Gembicki, M.; Wender, M.

    1997-01-01

    The purpose of our work was to compare the regional cerebral blood flow (rCBF) in SPECT examination in Parkinson's disease with (17 cases) and without (7 cases) dementia and in various clinical stages of the disease. The patients underwent SPECT examination 5-40 min after intravenous application of HMPAO (Ceretec, Amersham) with 740 Mbq (20 mCi) pertechnate 99m Tc. SPECT was performed with a Siemens Diacam single-head rotating gamma camera coupled to a high resolution collimator and Icon computer system provided by the manufacturer. The results were defined in relative values of ROI in relation to cerebellum. Patients with Parkinson's disease showed hypoperfusion in cerebral lobes and in deep cerebral structures including the basal ganglia. Regional perfusion deficit in SPECT was seen with and without associated dementia and already in early stage of the disease. Parkinson's disease is provoked by the lesions of dopaminergic neurons of the central nervous system leading to domination of extrapyramidal symptoms. There are many indications that also the neurotransmitters associated with cognitive functions as acetylcholine demonstrate some abnormalities. However, only in some cases of Parkinson's disease dementia is the dominating symptom. Our results of regional cerebral blood flow testify that in Parkinson's disease the dysfunction of the central nervous system is more diffuse than has previously been suggested. (author)

  20. Small hepatocellular carcinomas in chronic liver disease: Detection with SPECT

    Energy Technology Data Exchange (ETDEWEB)

    Kudo, M.; Hirasa, M.; Takakuwa, H.; Ibuki, Y.; Fujimi, K.; Miyamura, M.; Tomita, S.; Komori, H.; Todo, A.; Kitaura, Y.

    1986-06-01

    Single-photon emission computed tomography (SPECT) performed using a rotating gamma camera was compared with ..cap alpha../sub 1/-fetoprotein (AFP) assay, conventional liver scintigraphy, ultrasound (US) imaging, computed tomography (CT), and selective celiac angiography in 40 patients with a total of 50 small hepatocellular carcinomas (HCCs;<5 cm). The detection rates of US and CT were determined on an initial screening study and on a second, more precisely focused study. The detection rate of small HCCs by the various modalities was as follows: AFP, 13%; liver scintigraphy, 36%; SPECT, 72%; initial screening US, 80%; second, more precise US studies, 94%; initial screening CT, 64%; second, more precise CT study, 82%; angiography, 88%. Although SPECT was inferior to the initial screening US examination in detecting HCCs less than 2 cm in size, its sensitivity was identical to that of the initial screening US study for detecting HCCs of 2-5 cm. The combination of SPECT and US was an excellent method for the early detection of HCCs, yielding a detection rate of 94%.

  1. Clinical applications of SPECT/CT: advantages and limitations

    International Nuclear Information System (INIS)

    Rigo, P.

    2006-01-01

    The application of hybrid SPECT cameras in Nuclear Medicine follows the revolutionary introduction of PET/CT. This review focuses on the advantages and limitations of SPECT/CT in its various clinical indications. It appears that SPECT/CT will be a clear factor of progress for Nuclear Medicine. (author)

  2. Implementation and Evaluation of Pinhole SPECT

    International Nuclear Information System (INIS)

    MacArtain Anne Marie

    2002-08-01

    The aim of this work was to implement Pinhole SPECT into a working Nuclear Medicine department. It has been reported that pinhole SPECT has been successfully performed to visualise pathology in ankle bones using gamma camera and the images were constructed using a standard filtered back-projection algorithm (Bahk YW, 1998). The objective of this study was to produce and evaluate this technique with the equipment available in the nuclear medicine department. The system performance was assessed using both the low-energy high resolution and the pinhole collimators. Phantoms constructed using capillary tubes, filled with technetium 99m (pertechnetate) were imaged in different arrays to identify possible limitations in the reconstruction software. A thyroid phantom with hot and cold inserts was also imaged. Data was acquired in ''tep-and-shoot'' mode as the camera was rotated 180 degrees or 360 degrees around the phantom. Images were reconstructed using standard parallel back-projection algorithm and a weighted backprojection algorithm (Nowak). An attempt was made to process images of the phantom in Matlab using the Iradon function modified by application of a cone-beam type algorithm (Feldkamp L, 1984). Visual comparison of static images between the pinhole and the LEHR collimators showed the expected improved spatial resolution of the pinhole images. Pinhole SPECT images should be reconstructed using the appropriate cone beam algorithm. However, it was established that reconstructing pinhole SPECT images using a standard parallel backprojection algorithm yielded results which were deemed to be clinically useful. The Nowak algorithm results were a distinct improvement on those achieved with the parallel backprojection algorithm. Likewise the results from the cone beam algorithm were better than the former but not as good as those obtained from the Nowak algorithm. This was due to the fact that the cone beam algorithm did not include a weighting factor. Implementation

  3. Measurement of the iodine uptake by the thyroid: comparative analysis between the gamma camera system with 'pinhole' collimator and 13S002 system

    International Nuclear Information System (INIS)

    Silva, Carlos Borges da; Mello, Rossana Corbo R. de; Rebelo, Ana Maria O.

    2002-01-01

    The thyroid uptake measurements are common in medical uses and are considered a direct and precise form of diagnostic, however, different results have been observed as measurements of thyroid uptake are taken using distinct equipment. This study attempts to find the cause of the differences between a thyroid uptake probe and a gamma camera. These discrepancies can be associated to the different patients samples, equipment's problems or operator procedures errors. This work presents the results of comparative uptake measurements performed in a neck phantom and a 4-hour thyroid uptake study in 40 patients, using a Gamma Camera Ohio Nuclear model Sigma 410 with a pinhole collimator and Nuclear Medicine System model 13S002, developed by Instituto de Engenharia Nuclear. The results observed show that in spite of non satisfactory results commented in literature, both the System 13S002 and System Gamma Camera Ohio can be used in uptake thyroid diagnostic with statistical confidence degree of 99 %. (author)

  4. Localization of the placenta in the 3 trimester of gestation with the use of a gamma-camera and radioactive sup(113m)In indium isotope

    Energy Technology Data Exchange (ETDEWEB)

    Brudnik, A.; Chromy, G.; Ulfik, A.; Bielawski, J.; Wasylewski, A. (Slaska Akademia Medyczna, Katowice (Poland))

    1980-01-01

    In 56 women, treated because of uterine bleedings in the 3 trimester of gestation the localization of the placenta was looked for with use of a gamma camera (Toshiba Co.) and indium radioisotope 113-In. The methodic procedures were elaborated for the application of the gamma-camera and the utilization of radioactive marker /sup 125/Sb in the anatomic reference areas. Full conformity of results with findings at cesarean section was met. Isotope placentography with the application of gamma camera gives a high percentage of adequate diagnoses, least dose of exposition, uncomplicated procedures. The negative diagnosis in suspected cases of placenta previa permitted to decrease the time of hospital stay in a number of cases observed because of uterine bleedings in the 3 trimester of pregnancy.

  5. Localization of the placenta in the 3 trimester of gestation with the use of a gamma-camera and radioactive sup(113m)In indium isotope

    International Nuclear Information System (INIS)

    Brudnik, A.; Chromy, G.; Ulfik, A.; Bielawski, J.; Wasylewski, A.

    1980-01-01

    In 56 women, treated because of uterine bleedings in the 3 trimester of gestation the localization of the placenta was looked for with use of a gamma camera (Toshiba Co.) and indium radioisotope 113-In. The methodic procedures were elaborated for the application of the gamma-camera and the utilization of radioactive marker 125 Sb in the anatomic reference areas. Full conformity of results with findings at cesarean section was met. Isotope placentography with the application of gamma camera gives a high percentage of adequate diagnoses, least dose of exposition, uncomplicated procedures. The negative diagnosis in suspected cases of placenta previa permitted to decrease the time of hospital stay in a number of cases observed because of uterine bleedings in the 3 trimester of pregnancy. (author)

  6. An innovative silicon photomultiplier digitizing camera for gamma-ray astronomy

    Energy Technology Data Exchange (ETDEWEB)

    Heller, M. [DPNC-Universite de Geneve, Geneva (Switzerland); Schioppa, E. Jr; Porcelli, A.; Pujadas, I.T.; Della Volpe, D.; Montaruli, T.; Cadoux, F.; Favre, Y.; Christov, A.; Rameez, M.; Miranda, L.D.M. [DPNC-Universite de Geneve, Geneva (Switzerland); Zietara, K.; Idzkowski, B.; Jamrozy, M.; Ostrowski, M.; Stawarz, L.; Zagdanski, A. [Jagellonian University, Astronomical Observatory, Krakow (Poland); Aguilar, J.A. [DPNC-Universite de Geneve, Geneva (Switzerland); Universite Libre Bruxelles, Faculte des Sciences, Brussels (Belgium); Prandini, E.; Lyard, E.; Neronov, A.; Walter, R. [Universite de Geneve, Department of Astronomy, Geneva (Switzerland); Rajda, P.; Bilnik, W.; Kasperek, J.; Lalik, K.; Wiecek, M. [AGH University of Science and Technology, Krakow (Poland); Blocki, J.; Mach, E.; Michalowski, J.; Niemiec, J.; Skowron, K.; Stodulski, M. [Instytut Fizyki Jadrowej im. H. Niewodniczanskiego Polskiej Akademii Nauk, Krakow (Poland); Bogacz, L. [Jagiellonian University, Department of Information Technologies, Krakow (Poland); Borkowski, J.; Frankowski, A.; Janiak, M.; Moderski, R. [Polish Academy of Science, Nicolaus Copernicus Astronomical Center, Warsaw (Poland); Bulik, T.; Grudzinska, M. [University of Warsaw, Astronomical Observatory, Warsaw (Poland); Mandat, D.; Pech, M.; Schovanek, P. [Institute of Physics of the Czech Academy of Sciences, Prague (Czech Republic); Marszalek, A.; Stodulska, M. [Instytut Fizyki Jadrowej im. H. Niewodniczanskiego Polskiej Akademii Nauk, Krakow (Poland); Jagellonian University, Astronomical Observatory, Krakow (Poland); Pasko, P.; Seweryn, K. [Centrum Badan Kosmicznych Polskiej Akademii Nauk, Warsaw (Poland); Sliusar, V. [Universite de Geneve, Department of Astronomy, Geneva (Switzerland); Taras Shevchenko National University of Kyiv, Astronomical Observatory, Kyiv (Ukraine)

    2017-01-15

    The single-mirror small-size telescope (SST-1M) is one of the three proposed designs for the small-size telescopes (SSTs) of the Cherenkov Telescope Array (CTA) project. The SST-1M will be equipped with a 4 m-diameter segmented reflector dish and an innovative fully digital camera based on silicon photo-multipliers. Since the SST sub-array will consist of up to 70 telescopes, the challenge is not only to build telescopes with excellent performance, but also to design them so that their components can be commissioned, assembled and tested by industry. In this paper we review the basic steps that led to the design concepts for the SST-1M camera and the ongoing realization of the first prototype, with focus on the innovative solutions adopted for the photodetector plane and the readout and trigger parts of the camera. In addition, we report on results of laboratory measurements on real scale elements that validate the camera design and show that it is capable of matching the CTA requirements of operating up to high moonlight background conditions. (orig.)

  7. Development of a gamma camera based on a multiwire proportional counter

    International Nuclear Information System (INIS)

    Anisimov, Yu.S.; Zanevskij, Yu.V.; Ivanov, A.B.

    1981-01-01

    The developed high-pressure gamma-chamber based on a gas multiwire detector is discussed. The main characteristics of the detector for a gamma-ray energy of up to 100 keV are given. The chamber operation is possible at a pressure of up to 10 atm. The detector is filled with a Xe-CH 4 (90-10) mixture. The detector efficiency is about 50%, the space resolution is better than 2 mm at a working region of 280x280 mm [ru

  8. The HURRA filter: An easy method to eliminate collimator artifacts in high-energy gamma camera images.

    Science.gov (United States)

    Perez-Garcia, H; Barquero, R

    The correct determination and delineation of tumor/organ size is crucial in 2-D imaging in 131 I therapy. These images are usually obtained using a system composed of a Gamma camera and high-energy collimator, although the system can produce artifacts in the image. This article analyses these artifacts and describes a correction filter that can eliminate those collimator artifacts. Using free software, ImageJ, a central profile in the image is obtained and analyzed. Two components can be seen in the fluctuation of the profile: one associated with the stochastic nature of the radiation, plus electronic noise and the other periodically across the position in space due to the collimator. These frequencies are analytically obtained and compared with the frequencies in the Fourier transform of the profile. A specially developed filter removes the artifacts in the 2D Fourier transform of the DICOM image. This filter is tested using a 15-cm-diameter Petri dish with 131 I radioactive water (big object size) image, a 131 I clinical pill (small object size) image, and an image of the remainder of the lesion of two patients treated with 3.7GBq (100mCi), and 4.44GBq (120mCi) of 131 I, respectively, after thyroidectomy. The artifact is due to the hexagonal periodic structure of the collimator. The use of the filter on large-sized images reduces the fluctuation by 5.8-3.5%. In small-sized images, the FWHM can be determined in the filtered image, while this is impossible in the unfiltered image. The definition of tumor boundary and the visualization of the activity distribution inside patient lesions improve drastically when the filter is applied to the corresponding images obtained with HE gamma camera. The HURRA filter removes the artifact of high-energy collimator artifacts in planar images obtained with a Gamma camera without reducing the image resolution. It can be applied in any study of patient quantification because the number of counts remains invariant. The filter makes

  9. A data acquisition system for coincidence imaging using a conventional dual head gamma camera

    Science.gov (United States)

    Lewellen, T. K.; Miyaoka, R. S.; Jansen, F.; Kaplan, M. S.

    1997-06-01

    A low cost data acquisition system (DAS) was developed to acquire coincidence data from an unmodified General Electric Maxxus dual head scintillation camera. A high impedance pick-off circuit provides position and energy signals to the DAS without interfering with normal camera operation. The signals are pulse-clipped to reduce pileup effects. Coincidence is determined with fast timing signals derived from constant fraction discriminators. A charge-integrating FERA 16 channel ADC feeds position and energy data to two CAMAC FERA memories operated as ping-pong buffers. A Macintosh PowerPC running Labview controls the system and reads the CAMAC memories. A CAMAC 12-channel scaler records singles and coincidence rate data. The system dead-time is approximately 10% at a coincidence rate of 4.0 kHz.

  10. A data acquisition system for coincidence imaging using a conventional dual head gamma camera

    International Nuclear Information System (INIS)

    Lewellen, T.K.; Miyaoka, R.S.; Kaplan, M.S.

    1996-01-01

    A low cost data acquisition system (DAS) was developed to acquire coincidence data from an unmodified General Electric Maxxus dual head scintillation camera. A high impedance pick-off circuit provides position and energy signals to the DAS without interfering with normal camera operation. The signals are pulse-clipped to reduce pileup effects. Coincidence is determined with fast timing signals derived from constant fraction discriminators. A charge-integrating FERA 16 channel ADC feeds position and energy data to two CAMAC FERA memories operated as ping-pong buffers. A Macintosh PowerPC running Labview controls the system and reads the CAMAC memories. A CAMAC 12-channel scaler records singles and coincidence rate data. The system dead-time is approximately 10% at a coincidence rate of 4.0 kHz

  11. Practical reconstruction protocol for quantitative 90Y bremsstrahlung SPECT/CT

    International Nuclear Information System (INIS)

    Siman, W.; Mikell, J. K.; Kappadath, S. C.

    2016-01-01

    Purpose: To develop a practical background compensation (BC) technique to improve quantitative 90 Y-bremsstrahlung single-photon emission computed tomography (SPECT)/computed tomography (CT) using a commercially available imaging system. Methods: All images were acquired using medium-energy collimation in six energy windows (EWs), ranging from 70 to 410 keV. The EWs were determined based on the signal-to-background ratio in planar images of an acrylic phantom of different thicknesses (2–16 cm) positioned below a 90 Y source and set at different distances (15–35 cm) from a gamma camera. The authors adapted the widely used EW-based scatter-correction technique by modeling the BC as scaled images. The BC EW was determined empirically in SPECT/CT studies using an IEC phantom based on the sphere activity recovery and residual activity in the cold lung insert. The scaling factor was calculated from 20 clinical planar 90 Y images. Reconstruction parameters were optimized in the same SPECT images for improved image quantification and contrast. A count-to-activity calibration factor was calculated from 30 clinical 90 Y images. Results: The authors found that the most appropriate imaging EW range was 90–125 keV. BC was modeled as 0.53× images in the EW of 310–410 keV. The background-compensated clinical images had higher image contrast than uncompensated images. The maximum deviation of their SPECT calibration in clinical studies was lowest (<10%) for SPECT with attenuation correction (AC) and SPECT with AC + BC. Using the proposed SPECT-with-AC + BC reconstruction protocol, the authors found that the recovery coefficient of a 37-mm sphere (in a 10-mm volume of interest) increased from 39% to 90% and that the residual activity in the lung insert decreased from 44% to 14% over that of SPECT images with AC alone. Conclusions: The proposed EW-based BC model was developed for 90 Y bremsstrahlung imaging. SPECT with AC + BC gave improved lesion detectability and activity

  12. Practical reconstruction protocol for quantitative {sup 90}Y bremsstrahlung SPECT/CT

    Energy Technology Data Exchange (ETDEWEB)

    Siman, W.; Mikell, J. K.; Kappadath, S. C., E-mail: skappadath@mdanderson.org [Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030 and The University of Texas Graduate School of Biomedical Sciences at Houston, Houston, Texas 77030 (United States)

    2016-09-15

    Purpose: To develop a practical background compensation (BC) technique to improve quantitative {sup 90}Y-bremsstrahlung single-photon emission computed tomography (SPECT)/computed tomography (CT) using a commercially available imaging system. Methods: All images were acquired using medium-energy collimation in six energy windows (EWs), ranging from 70 to 410 keV. The EWs were determined based on the signal-to-background ratio in planar images of an acrylic phantom of different thicknesses (2–16 cm) positioned below a {sup 90}Y source and set at different distances (15–35 cm) from a gamma camera. The authors adapted the widely used EW-based scatter-correction technique by modeling the BC as scaled images. The BC EW was determined empirically in SPECT/CT studies using an IEC phantom based on the sphere activity recovery and residual activity in the cold lung insert. The scaling factor was calculated from 20 clinical planar {sup 90}Y images. Reconstruction parameters were optimized in the same SPECT images for improved image quantification and contrast. A count-to-activity calibration factor was calculated from 30 clinical {sup 90}Y images. Results: The authors found that the most appropriate imaging EW range was 90–125 keV. BC was modeled as 0.53× images in the EW of 310–410 keV. The background-compensated clinical images had higher image contrast than uncompensated images. The maximum deviation of their SPECT calibration in clinical studies was lowest (<10%) for SPECT with attenuation correction (AC) and SPECT with AC + BC. Using the proposed SPECT-with-AC + BC reconstruction protocol, the authors found that the recovery coefficient of a 37-mm sphere (in a 10-mm volume of interest) increased from 39% to 90% and that the residual activity in the lung insert decreased from 44% to 14% over that of SPECT images with AC alone. Conclusions: The proposed EW-based BC model was developed for {sup 90}Y bremsstrahlung imaging. SPECT with AC + BC gave improved lesion

  13. [F18]-FDG imaging of experimental animal tumours using a hybrid gamma-camera

    International Nuclear Information System (INIS)

    Lausson, S.; Maurel, G.; Kerrou, K.; Montravers, F.; Petegnief, Y.; Talbot, J.N.; Fredelizi, D.

    2001-01-01

    Positron emission tomography (PET) has been widely used in clinical studies. This technology permits detection of compounds labelled with positron emitting radionuclides and in particular, [F18]-fluorodeoxyglucose ([F18]-FDG).[F18]-FDG uptake and accumulation is generally related to malignancy; some recent works have suggested the usefulness of PET camera dedicated to small laboratory animals (micro-PET). Our study dealt with the feasibility of [F18]-FDG imaging of malignant tumours in animal models by means of an hybrid camera dedicated for human scintigraphy. We evaluated the ability of coincidence detection emission tomography (CDET) using this hybrid camera to visualize in vivo subcutaneous tumours grafted to mice or rats. P815 murine mastocytoma grafted in syngeneic DBA/2 mice resulted with foci of very high FDG uptake. Tumours with a diameter of only 3 mm were clearly visualized. Medullary thyroid cancer provoked by rMTC 6/23 and CA77 lines in syngeneic Wag/Rij rat was also detected. The differentiated CA77 tumours exhibited avidity for [F18]-FDG and a tumour, which was just palpable (diameter lower than 2 mm), was identified. In conclusion, CDET-FDG is a non-invasive imaging tool which can be used to follow grafted tumours in the small laboratory animal, even when their size is smaller than 1 cm. It has the potential to evaluate experimental anticancer treatments in small series of animals by individual follow-up. It offers the opportunity to develop experimental PET research within a nuclear medicine or biophysics department, the shift to a dedicated micro-PET device being subsequently necessary. It is indeed compulsory to strictly follow the rules for non contamination and disinfection of the hybrid camera. (authors)

  14. A machine learning method for fast and accurate characterization of depth-of-interaction gamma cameras

    DEFF Research Database (Denmark)

    Pedemonte, Stefano; Pierce, Larry; Van Leemput, Koen

    2017-01-01

    to impose the depth-of-interaction in an experimental set-up. In this article we introduce a machine learning approach for extracting accurate forward models of gamma imaging devices from simple pencil-beam measurements, using a nonlinear dimensionality reduction technique in combination with a finite...

  15. Clinical correlative evaluation of an iterative method for reconstruction of brain SPECT images

    International Nuclear Information System (INIS)

    Nobili, Flavio; Vitali, Paolo; Calvini, Piero; Bollati, Francesca; Girtler, Nicola; Delmonte, Marta; Mariani, Giuliano; Rodriguez, Guido

    2001-01-01

    Background: Brain SPECT and PET investigations have showed discrepancies in Alzheimer's disease (AD) when considering data deriving from deeply located structures, such as the mesial temporal lobe. These discrepancies could be due to a variety of factors, including substantial differences in gamma-cameras and underlying technology. Mesial temporal structures are deeply located within the brain and the commonly used Filtered Back-Projection (FBP) technique does not fully take into account either the physical parameters of gamma-cameras or geometry of collimators. In order to overcome these limitations, alternative reconstruction methods have been proposed, such as the iterative method of the Conjugate Gradients with modified matrix (CG). However, the clinical applications of these methods have so far been only anecdotal. The present study was planned to compare perfusional SPECT data as derived from the conventional FBP method and from the iterative CG method, which takes into account the geometrical and physical characteristics of the gamma-camera, by a correlative approach with neuropsychology. Methods: Correlations were compared between perfusion of the hippocampal region, as achieved by both the FBP and the CG reconstruction methods, and a short-memory test (Selective Reminding Test, SRT), specifically addressing one of its function. A brain-dedicated camera (CERASPECT) was used for SPECT studies with 99m Tc-hexamethylpropylene-amine-oxime in 23 consecutive patients (mean age: 74.2±6.5) with mild (Mini-Mental Status Examination score ≥15, mean 20.3±3), probable AD. Counts from a hippocampal region in each hemisphere were referred to the average thalamic counts. Results: Hippocampal perfusion significantly correlated with the MMSE score with similar statistical significance (p<0.01) between the two reconstruction methods. Correlation between hippocampal perfusion and the SRT score was better with the CG method (r=0.50 for both hemispheres, p<0.01) than with

  16. Clinical correlative evaluation of an iterative method for reconstruction of brain SPECT images

    Energy Technology Data Exchange (ETDEWEB)

    Nobili, Flavio E-mail: fnobili@smartino.ge.it; Vitali, Paolo; Calvini, Piero; Bollati, Francesca; Girtler, Nicola; Delmonte, Marta; Mariani, Giuliano; Rodriguez, Guido

    2001-08-01

    Background: Brain SPECT and PET investigations have showed discrepancies in Alzheimer's disease (AD) when considering data deriving from deeply located structures, such as the mesial temporal lobe. These discrepancies could be due to a variety of factors, including substantial differences in gamma-cameras and underlying technology. Mesial temporal structures are deeply located within the brain and the commonly used Filtered Back-Projection (FBP) technique does not fully take into account either the physical parameters of gamma-cameras or geometry of collimators. In order to overcome these limitations, alternative reconstruction methods have been proposed, such as the iterative method of the Conjugate Gradients with modified matrix (CG). However, the clinical applications of these methods have so far been only anecdotal. The present study was planned to compare perfusional SPECT data as derived from the conventional FBP method and from the iterative CG method, which takes into account the geometrical and physical characteristics of the gamma-camera, by a correlative approach with neuropsychology. Methods: Correlations were compared between perfusion of the hippocampal region, as achieved by both the FBP and the CG reconstruction methods, and a short-memory test (Selective Reminding Test, SRT), specifically addressing one of its function. A brain-dedicated camera (CERASPECT) was used for SPECT studies with {sup 99m}Tc-hexamethylpropylene-amine-oxime in 23 consecutive patients (mean age: 74.2{+-}6.5) with mild (Mini-Mental Status Examination score {>=}15, mean 20.3{+-}3), probable AD. Counts from a hippocampal region in each hemisphere were referred to the average thalamic counts. Results: Hippocampal perfusion significantly correlated with the MMSE score with similar statistical significance (p<0.01) between the two reconstruction methods. Correlation between hippocampal perfusion and the SRT score was better with the CG method (r=0.50 for both hemispheres, p<0

  17. Measurement of cerebral blood flow the blood sampling method using 99mTc-ECD. Simultaneous scintigram scanning of arterial blood samples and the brain with a gamma camera

    International Nuclear Information System (INIS)

    Hachiya, Takenori; Inugami, Atsushi; Iida, Hidehiro; Mizuta, Yoshihiko; Kawakami, Takeshi; Inoue, Minoru

    1999-01-01

    To measure regional cerebral blood flow (rCBF) by blood sampling using 99m Tc-ECD we devised a method of measuring the radioactive concentration in arterial blood sample with a gamma camera. In this method the head and a blood sample are placed within the same visual field to record the SPECT data of both specimens simultaneously. The results of an evaluation of the counting rate performance, applying the 30 hours decaying method using 99m Tc solution showed that this method is not comparable to the well-type scintillation counter and in clinical cases the active concentration in arterial blood sample remained well within the dynamic range. In addition, examination of the influence of scattered radiation from the brain by the dilution method showed that it was negligible at a distance of more than 7.5 cm between the brain and the arterial blood sample. In the present study we placed a head-shaped phantom next to the sample. The results of the examinations suggested that this method is suitable for clinical application, and because it does not require a well-type scintillation counter, it is expected to find wide application. (author)

  18. A gamma camera count rate saturation correction method for whole-body planar imaging

    Science.gov (United States)

    Hobbs, Robert F.; Baechler, Sébastien; Senthamizhchelvan, Srinivasan; Prideaux, Andrew R.; Esaias, Caroline E.; Reinhardt, Melvin; Frey, Eric C.; Loeb, David M.; Sgouros, George

    2010-02-01

    Whole-body (WB) planar imaging has long been one of the staple methods of dosimetry, and its quantification has been formalized by the MIRD Committee in pamphlet no 16. One of the issues not specifically addressed in the formalism occurs when the count rates reaching the detector are sufficiently high to result in camera count saturation. Camera dead-time effects have been extensively studied, but all of the developed correction methods assume static acquisitions. However, during WB planar (sweep) imaging, a variable amount of imaged activity exists in the detector's field of view as a function of time and therefore the camera saturation is time dependent. A new time-dependent algorithm was developed to correct for dead-time effects during WB planar acquisitions that accounts for relative motion between detector heads and imaged object. Static camera dead-time parameters were acquired by imaging decaying activity in a phantom and obtaining a saturation curve. Using these parameters, an iterative algorithm akin to Newton's method was developed, which takes into account the variable count rate seen by the detector as a function of time. The algorithm was tested on simulated data as well as on a whole-body scan of high activity Samarium-153 in an ellipsoid phantom. A complete set of parameters from unsaturated phantom data necessary for count rate to activity conversion was also obtained, including build-up and attenuation coefficients, in order to convert corrected count rate values to activity. The algorithm proved successful in accounting for motion- and time-dependent saturation effects in both the simulated and measured data and converged to any desired degree of precision. The clearance half-life calculated from the ellipsoid phantom data was calculated to be 45.1 h after dead-time correction and 51.4 h with no correction; the physical decay half-life of Samarium-153 is 46.3 h. Accurate WB planar dosimetry of high activities relies on successfully compensating

  19. Multiaxial tomography of heart chambers by gated blood-pool emission computed tomography using a rotating gamma camera

    International Nuclear Information System (INIS)

    Tamaki, N.; Mukai, T.; Ishii, Y.; Yonekura, Y.; Yamamoto, K.; Kadota, K.; Kambara, H.; Kawai, C.; Torizuka, K.

    1983-01-01

    Fifteen patients and three volunteers underwent radionuclide blood-pool cardiac studies with electrocardiographic gating. Following conventional planar-gated imaging (anterior and left anterior oblique projections), emission computed tomography (ECT), using a rotating gamma camera, was performed.A series of transaxial tomograms of the cardiac chambers was obtained. The left ventricular short-axis plane, long-axis plane, and four-chamber-view plane were then reorganized; each chamber was visualized separately. Compared to gated planar imaging, this technique showed regional asynergy more clearly in patients with myocardial infarction and demonstrated dilatation of the atria and ventricles more accurately in patients with an atrial septal defect and valvular heart diseases. In addition, when a section of the heart is otained at any angle with gated blood pool ECT, three-dimensional assessment of cardiac chambers in motion is more precise; mutual superimposition becomes unnecessary

  20. ORIS: the Oak Ridge Imaging System program listings. [Nuclear medicine imaging with rectilinear scanner and gamma camera

    Energy Technology Data Exchange (ETDEWEB)

    Bell, P. R.; Dougherty, J. M.

    1978-04-01

    The Oak Ridge Imaging System (ORIS) is a general purpose access, storage, processing and display system for nuclear medicine imaging with rectilinear scanner and gamma camera. This volume contains listings of the PDP-8/E version of ORIS Version 2. The system is designed to run under the Digital Equipment Corporation's OS/8 monitor in 16K or more words of core. System and image file mass storage is on RK8E disk; longer-time image file storage is provided on DECtape. Another version of this program exists for use with the RF08 disk, and a more limited version is for DECtape only. This latter version is intended for non-medical imaging.

  1. Gamma-ray detection and Compton camera image reconstruction with application to hadron therapy

    International Nuclear Information System (INIS)

    Frandes, M.

    2010-09-01

    A novel technique for radiotherapy - hadron therapy - irradiates tumors using a beam of protons or carbon ions. Hadron therapy is an effective technique for cancer treatment, since it enables accurate dose deposition due to the existence of a Bragg peak at the end of particles range. Precise knowledge of the fall-off position of the dose with millimeters accuracy is critical since hadron therapy proved its efficiency in case of tumors which are deep-seated, close to vital organs, or radio-resistant. A major challenge for hadron therapy is the quality assurance of dose delivery during irradiation. Current systems applying positron emission tomography (PET) technologies exploit gamma rays from the annihilation of positrons emitted during the beta decay of radioactive isotopes. However, the generated PET images allow only post-therapy information about the deposed dose. In addition, they are not in direct coincidence with the Bragg peak. A solution is to image the complete spectrum of the emitted gamma rays, including nuclear gamma rays emitted by inelastic interactions of hadrons to generated nuclei. This emission is isotropic, and has a spectrum ranging from 100 keV up to 20 MeV. However, the measurement of these energetic gamma rays from nuclear reactions exceeds the capability of all existing medical imaging systems. An advanced Compton scattering detection method with electron tracking capability is proposed, and modeled to reconstruct the high-energy gamma-ray events. This Compton detection technique was initially developed to observe gamma rays for astrophysical purposes. A device illustrating the method was designed and adapted to Hadron Therapy Imaging (HTI). It consists of two main sub-systems: a tracker where Compton recoiled electrons are measured, and a calorimeter where the scattered gamma rays are absorbed via the photoelectric effect. Considering a hadron therapy scenario, the analysis of generated data was performed, passing trough the complete

  2. Experimental evaluation of an online gamma-camera imaging of permanent seed implantation (OGIPSI) prototype for partial breast irradiation

    International Nuclear Information System (INIS)

    Ravi, Ananth; Caldwell, Curtis B.; Pignol, Jean-Philippe

    2008-01-01

    Previously, our team used Monte Carlo simulation to demonstrate that a gamma camera could potentially be used as an online image guidance device to visualize seeds during permanent breast seed implant procedures. This could allow for intraoperative correction if seeds have been misplaced. The objective of this study is to describe an experimental evaluation of an online gamma-camera imaging of permanent seed implantation (OGIPSI) prototype. The OGIPSI device is intended to be able to detect a seed misplacement of 5 mm or more within an imaging time of 2 min or less. The device was constructed by fitting a custom built brass collimator (16 mm height, 0.65 mm hole pitch, 0.15 mm septal thickness) on a 64 pixel linear array CZT detector (eValuator-2000, eV Products, Saxonburg, PA). Two-dimensional projection images of seed distributions were acquired by the use of a digitally controlled translation stage. Spatial resolution and noise characteristics of the detector were measured. The ability and time needed for the OGIPSI device to image the seeds and to detect cold spots was tested using an anthropomorphic breast phantom. Mimicking a real treatment plan, a total of 52 103 Pd seeds of 65.8 MBq each were placed on three different layers at appropriate depths within the phantom. The seeds were reliably detected within 30 s with a median error in localization of 1 mm. In conclusion, an OGIPSI device can potentially be used for image guidance of permanent brachytherapy applications in the breast and, possibly, other sites

  3. Prognostic value of normal stress-only myocardial perfusion imaging: a comparison between conventional and CZT-based SPECT

    Energy Technology Data Exchange (ETDEWEB)

    Yokota, Shu; Ottervanger, Jan Paul; Timmer, Jorik R. [Isala Hospital, Department of Cardiology, Zwolle (Netherlands); Mouden, Mohamed; Engbers, Elsemiek [Isala Hospital, Department of Cardiology, Zwolle (Netherlands); Isala Hospital, Department of Nuclear Medicine, Zwolle (Netherlands); Knollema, Siert; Jager, Pieter L. [Isala Hospital, Department of Nuclear Medicine, Zwolle (Netherlands)

    2016-02-15

    Single photon emission computed tomography (SPECT) myocardial perfusion imaging has proven to have prognostic importance in patients with suspected stable coronary artery disease (CAD). The recently introduced ultrafast cadmium zinc telluride (CZT)-based gamma cameras have been associated with less equivocal findings and more normal interpretations, allowing stress-only imaging to be performed more often. However, it is yet unclear whether normal stress-only CZT SPECT has comparable prognostic value as normally interpreted stress-only conventional SPECT. The study population consisted of 1,650 consecutive patients without known CAD with normal stress-only myocardial perfusion results with either conventional (n = 362) or CZT SPECT (n = 1,288). The incidence of major adverse cardiac events (MACE, all-cause death, non-fatal myocardial infarction and/or coronary revascularization) was compared between the conventional SPECT and CZT SPECT groups. Multivariable analyses using the Cox model were used to adjust for differences in baseline variables. Patients scanned with CZT were less often male (33 vs 39 %), had less often hypercholesterolaemia (41 vs 50 %) and had more often a family history of CAD (57 vs 49 %). At a median follow-up time of 37 months (interquartile range 28-45 months) MACE occurred in 68 patients. The incidence of MACE was 1.5 %/year in the CZT group, compared to 2.0 %/year in the conventional group (p = 0.08). After multivariate analyses, there was a trend to a lower incidence of MACE in the CZT SPECT group (hazard ratio 0.61, 95 % confidence interval 0.35-1.04, p = 0.07). The prognostic value of normal stress-only CZT SPECT is at least comparable and may be even better than that of normal conventional stress SPECT. (orig.)

  4. Measurement of glomerular filtration rate using technetium-99m-DTPA and the gamma camera: A comparison of methods

    International Nuclear Information System (INIS)

    Russell, C.D.; Bischoff, P.G.; Kontzen, F.; Rowell, K.L.; Yester, M.V.; Lloyd, L.K.; Tauxe, W.N.; Dubovsky, E.V.

    1984-01-01

    A variety of methods has been proposed to estimate glomerular filtration rate (GFR) from renal uptake of Tc-99m-DTPA using a gamma camera. To compare alternative methods, the authors have calculated GFR in several different ways from measurements in 33 patients, and compared the results with an independent GFR measurement based on 8-point plasma clearance of Yb-169-DTPA. The best agreement was obtained using an algorithm that has not been described previously. This was a modification of a method used previously in which correction was made for overlap of kidneys by liver and spleen. The correlation coefficient was 0.958 and the residual standard deviation was 12.1 ml/min. This method required a single 20-min blood sample as well as the camera data. The best method not requiring a blood sample was significantly less accurate, with correlation coefficient 0.866 and residual standard deviation 21.1 ml/min. The accuracy of these methods was comparable to that reported for the creatinine clearance, the most commonly used estimate of GFR in current clinical practice

  5. Physical assessment of the GE/CGR Neurocam and comparison with a single rotating gamma-camera

    International Nuclear Information System (INIS)

    Kouris, K.; Jarritt, P.H.; Costa, D.C.; Ell, P.J.

    1992-01-01

    The GE/CGR Neurocam is a triple-headed single photon emission tomography (SPET) system dedicated to multi-slice brain tomography. We have assessed its physical performance in terms of sensitivity and resolution, and its clinical efficacy in comparison with a modern, single, rotating gamma-camera (GE 400XCT). Using a water-filled cylinder containing TC-99m, the tomographic volume sensitivity of the Neurocam was 30.0 and 50.7 kcps/MBq.ml.cm for the high-resolution and general-purpose collimators, respectively; the corresponding values for the single rotating camera were 7.6 and 12.8 kcps/MBq.ml.cm. Tomographic resolution was measured in air and in water. In air, the Neurocam resolution at the centre of the field-of-view is 9.0 and 10.7 mm full width at half-maximum (FWHM) with the collimators, respectively, and is isotropic in the three orthogonal planes; the resolution of the GE 400XCT with its 13-cm radius of rotation is 10.3 and 11.7 mm, respectively. For the Neurocam with the HR collimator, the transaxial FWHM values in water were 9.7 mm at the centre and 9.5 mm radial (6.6 mm tangential) at 8 cm from the centre. The physical characteristics of the Neurocam enable the routine acquisition of brain perfusion data with Tc-99m hexamethyl-propylene amine oxime in about 14 min, yielding better image quality than with a single rotating camera in 40 min. (orig./HP)

  6. Electron-tracking Compton gamma-ray camera for small animal and phantom imaging

    Energy Technology Data Exchange (ETDEWEB)

    Kabuki, Shigeto, E-mail: kabuki@cr.scphys.kyoto-u.ac.j [Department of Physics, Gradulate School of Science, Kyoto University, Kyoto 606-8502 (Japan); Kimura, Hiroyuki; Amano, Hiroo [Department of Patho-functional Bioanalysis, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606-8501 (Japan); Nakamoto, Yuji [Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University, Kyoto 606-8507 (Japan); Kubo, Hidetoshi; Miuchi, Kentaro; Kurosawa, Shunsuke; Takahashi, Michiaki [Department of Physics, Gradulate School of Science, Kyoto University, Kyoto 606-8502 (Japan); Kawashima, Hidekazu [Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University, Kyoto 606-8507 (Japan); Ueda, Masashi [Radioisotopes Research Labaoratory, Kyoto University Hospital, Kyoto 606-8507 (Japan); Okada, Tomohisa [Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University, Kyoto 606-8507 (Japan); Kubo, Atsushi; Kunieda, Etuso; Nakahara, Tadaki [Department of Radiology, Keio University School of Medicine, Tokyo 160-8582 (Japan); Kohara, Ryota; Miyazaki, Osamu; Nakazawa, Tetsuo; Shirahata, Takashi; Yamamoto, Etsuji [Application Development Office, Hitachi Medical Corporation, Chiba 277-0804 (Japan); Ogawa, Koichi [Department of Electronic Informatics, Faculty of Engineering, Hosei University, Tokyo 184-8584 (Japan)

    2010-11-01

    We have developed an electron-tracking Compton camera (ETCC) for medical use. Our ETCC has a wide energy dynamic range (200-1300 keV) and wide field of view (3 sr), and thus has potential for advanced medical use. To evaluate the ETCC, we imaged the head (brain) and bladder of mice that had been administered with F-18-FDG. We also imaged the head and thyroid gland of mice using double tracers of F-18-FDG and I-131 ions.

  7. Detection of pulmonary embolism with combined ventilation-perfusion SPECT and low-dose CT: head-to-head comparison with multidetector CT angiography

    DEFF Research Database (Denmark)

    Gutte, Henrik; Mortensen, Jann; Jensen, Claus Verner

    2009-01-01

    The diagnosis of pulmonary embolism (PE) is usually established by a combination of clinical assessment, D-dimer testing, and imaging with either pulmonary ventilation-perfusion (V/Q) scintigraphy or pulmonary multidetector CT (MDCT) angiography. Both V/Q SPECT and MDCT angiography seem to have...... high diagnostic accuracy. However, only limited data directly comparing these 2 modalities are available. Hybrid gamma-camera/MDCT systems have been introduced and allow simultaneous 3-dimensional lung V/Q SPECT and MDCT angiography, suitable for diagnosing PE. The aim of our study was to compare...

  8. Reduction in camera-specific variability in [{sup 123}I]FP-CIT SPECT outcome measures by image reconstruction optimized for multisite settings: impact on age-dependence of the specific binding ratio in the ENC-DAT database of healthy controls

    Energy Technology Data Exchange (ETDEWEB)

    Buchert, Ralph; Lange, Catharina [Charite - Universitaetsmedizin Berlin, Department of Nuclear Medicine, Berlin (Germany); Kluge, Andreas; Bronzel, Marcus [ABX-CRO advanced pharmaceutical services Forschungsgesellschaft m.b.H., Dresden (Germany); Tossici-Bolt, Livia [University Hospital Southampton NHS Foundation Trust, Department of Medical Physics, Southampton (United Kingdom); Dickson, John [University College London Hospital NHS Foundation Trust, Institute of Nuclear Medicine, London (United Kingdom); Asenbaum, Susanne [Medical University of Vienna, Department of Nuclear Medicine, Vienna (Austria); Booij, Jan [University of Amsterdam, Department of Nuclear Medicine, Academic Medical Centre, Amsterdam (Netherlands); Kapucu, L. Oezlem Atay [Gazi University, Department of Nuclear Medicine, Faculty of Medicine, Ankara (Turkey); Svarer, Claus [Rigshospitalet and University of Copenhagen, Neurobiology Research Unit, Copenhagen (Denmark); Koulibaly, Pierre-Malick [University of Nice-Sophia Antipolis, Nuclear Medicine Department, Centre Antoine Lacassagne, Nice (France); Nobili, Flavio [University of Genoa, Department of Neuroscience (DINOGMI), Clinical Neurology Unit, Genoa (Italy); Pagani, Marco [CNR, Institute of Cognitive Sciences and Technologies, Rome (Italy); Karolinska Hospital, Department of Nuclear Medicine, Stockholm (Sweden); Sabri, Osama [University of Leipzig, Department of Nuclear Medicine, Leipzig (Germany); Sera, Terez [University of Szeged, Department of Nuclear Medicine and Euromedic Szeged, Szeged (Hungary); Tatsch, Klaus [Municipal Hospital of Karlsruhe Inc, Department of Nuclear Medicine, Karlsruhe (Germany); Borght, Thierry vander [CHU Namur, IREC, Nuclear Medicine Division, Universite catholique de Louvain, Yvoir (Belgium); Laere, Koen van [University Hospital and K.U. Leuven, Nuclear Medicine, Leuven (Belgium); Varrone, Andrea [Karolinska University Hospital, Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet, Stockholm (Sweden); Iida, Hidehiro [National Cerebral and Cardiovascular Center - Research Institute, Osaka (Japan)

    2016-07-15

    Quantitative estimates of dopamine transporter availability, determined with [{sup 123}I]FP-CIT SPECT, depend on the SPECT equipment, including both hardware and (reconstruction) software, which limits their use in multicentre research and clinical routine. This study tested a dedicated reconstruction algorithm for its ability to reduce camera-specific intersubject variability in [{sup 123}I]FP-CIT SPECT. The secondary aim was to evaluate binding in whole brain (excluding striatum) as a reference for quantitative analysis. Of 73 healthy subjects from the European Normal Control Database of [{sup 123}I]FP-CIT recruited at six centres, 70 aged between 20 and 82 years were included. SPECT images were reconstructed using the QSPECT software package which provides fully automated detection of the outer contour of the head, camera-specific correction for scatter and septal penetration by transmission-dependent convolution subtraction, iterative OSEM reconstruction including attenuation correction, and camera-specific ''to kBq/ml'' calibration. LINK and HERMES reconstruction were used for head-to-head comparison. The specific striatal [{sup 123}I]FP-CIT binding ratio (SBR) was computed using the Southampton method with binding in the whole brain, occipital cortex or cerebellum as the reference. The correlation between SBR and age was used as the primary quality measure. The fraction of SBR variability explained by age was highest (1) with QSPECT, independently of the reference region, and (2) with whole brain as the reference, independently of the reconstruction algorithm. QSPECT reconstruction appears to be useful for reduction of camera-specific intersubject variability of [{sup 123}I]FP-CIT SPECT in multisite and single-site multicamera settings. Whole brain excluding striatal binding as the reference provides more stable quantitative estimates than occipital or cerebellar binding. (orig.)

  9. Automatic lung segmentation in functional SPECT images using active shape models trained on reference lung shapes from CT.

    Science.gov (United States)

    Cheimariotis, Grigorios-Aris; Al-Mashat, Mariam; Haris, Kostas; Aletras, Anthony H; Jögi, Jonas; Bajc, Marika; Maglaveras, Nicolaos; Heiberg, Einar

    2018-02-01

    Image segmentation is an essential step in quantifying the extent of reduced or absent lung function. The aim of this study is to develop and validate a new tool for automatic segmentation of lungs in ventilation and perfusion SPECT images and compare automatic and manual SPECT lung segmentations with reference computed tomography (CT) volumes. A total of 77 subjects (69 patients with obstructive lung disease, and 8 subjects without apparent perfusion of ventilation loss) performed low-dose CT followed by ventilation/perfusion (V/P) SPECT examination in a hybrid gamma camera system. In the training phase, lung shapes from the 57 anatomical low-dose CT images were used to construct two active shape models (right lung and left lung) which were then used for image segmentation. The algorithm was validated in 20 patients, comparing its results to reference delineation of corresponding CT images, and by comparing automatic segmentation to manual delineations in SPECT images. The Dice coefficient between automatic SPECT delineations and manual SPECT delineations were 0.83 ± 0.04% for the right and 0.82 ± 0.05% for the left lung. There was statistically significant difference between reference volumes from CT and automatic delineations for the right (R = 0.53, p = 0.02) and left lung (R = 0.69, p automatic quantification of wide range of measurements.

  10. Determination of hyperactive areas of Cortex Cerebri with using brain SPECT study

    International Nuclear Information System (INIS)

    Stepien, A.; Pawlus, J.; Wasilewska-Radwanska, M.

    2004-01-01

    The aim of this study was the assessment of the ability to apply of SPECT technique to determination of hyperactive areas of cortex cerebri. Analysis included 50 patients (mean aged 44 - 58). Brain SPECT scanning was performed after 1 hour after the intravenous injection of 740 MBq of ethylcisteinate dimmer labeled 99m Technetium (99mTc-ECD) with the use one-head gamma camera with a low-energy, ultra-high resolution collimator. Qualitative and quantitative analysis was performed using specialised software. In 20 cases normal biodistribution of the radiotracer was observed (hyperactive areas in cerebellum and occiput). In patients with psychiatric and neurological disturbances hyperactive areas were visualized in 25 cases in temporal lobes, in 4 cases in parietal lobes and in 1 patient in frontal area and basal ganglia. It is concluded that a number of factors limit the wide-scale use of SPECT, including the sophistication of imaging equipment (single-head cameras are inferior to the newer multihead units) and the experience of the physicians interpreting the scans and utilizing the data. In many diseases physicians do not know which areas of the patient's brain according disorders. Brain SPECT study can be a very useful tool to evaluation of hyperactive areas of cortex cerebri. This technique visualization of cortex cerebri completes standard analysis of disorders of brain activity

  11. Development of a prototype gamma camera (Aladin) for use in decommissioning nuclear facilities

    International Nuclear Information System (INIS)

    Imbard, G.; Carcreff, H.

    1995-01-01

    Mapping the gamma activity of irradiating zones is often an important prerequisite in dismantling nuclear facilities. This operation is necessary to define a suitable decommissioning strategy before any work begins; it is also required during the procedure to measure the residual activity wherever dose rates are too high to allow human intervention. This paper summarizes the work carried out develop a prototype imaging system designed to display radioactive sources superimposed in real time over a visible light image on a video monitor. This project was developed from an earlier off-line system. (authors). 8 refs., 7 figs., 3 tabs

  12. Two New Types of Detector for X- or Gamma-Ray Cameras

    International Nuclear Information System (INIS)

    Kellershohn, C.; Desgrez, A.; Lansiart, A.

    1964-01-01

    X- or γ-ray cameras consist essentially of a hole-type or grid-type lens system together with a detector. The authors propose two kinds of detector quite different from the Anger device, which so far has been the only one in practical use. The first consists of a self-triggering spark chamber. This chamber, about 20 cm in diam. and filled with a rare gas (argon or xenon), forms a cathode and two grids. The cathode and the second grid are subjected to a potential difference of several kilovolts, somewhat lower than the breakdown voltage. The first cathode-grid space serves as an electron source under the action of the low-energy X- or γ-ray photons. The cathode can also be plated with a metal of high Z, or a crystal scintillator connected to a photocathode can be used. After suitable amplification, the sudden burst of charges due to electron multiplication in the Townsend avalanche produces a well localized spark with a delay of a fraction of a microsecond. The image is obtained with the aid of a camera whose shutter is permanently open. The second type of detector consists of a Csl (Tl) crystal connected to the photocathode of a Thomson tube, 20 cm in diam. and with electrostatic focusing. The image on the secondary screen of this tube is transferred by an optical device to the photocathode of a tube with parallel electric and magnetic field (manufactured by the English Electric Valve Company) and serving as shutter. Some of the light entering the optical device is received by a photomultiplier, which controls the opening of the shutter tube through an amplitude selector. This arrangement makes it possible to distinguish between the light due to the signal and that due to the noise of the Thomson tube. The shutter tube is opened only by the former. Since the shutter tube remains open for only an extremely short time, the signal-noise ratio of this detector arrangement is high enough to give an image on the end screen of the shutter tube using a permanently open

  13. Double and triple isotope gamma camera studies with energy selection after data collection

    International Nuclear Information System (INIS)

    Soussaline, F.; Raynaud, C.; Kacperek, A.; Kellershohn, C.; Sauce, M.; Zadje, C.

    1974-01-01

    A system comprising a Toshiba camera and a Informatek data processing system has been used to perform multiple isotope studies. A large window (30-550KeV) is used and the data can be manipulated after data collection, to form sets of dynamic frames for various energies. Linear combinations of matrices have been used to correct for scattering. Double isotope studies using 197Hg/198Au have been used to determine Hg renal uptake in man, and are compared to a previous technique requiring two separate data acquisitions. Animal (pig) renal experiments have been performed using 169 Yb/sup(99m)Tc/ 197 Hg. This pilot study gave good results and indicates the utility of the system for multiple isotope function studies in man [fr

  14. Contribution to the development of a gamma radiation camera for use in scintigraphy

    International Nuclear Information System (INIS)

    Felix, J.

    1969-10-01

    This report constitutes an attempt to study systematically the properties of the detection head of a multichannel collimating grid camera. The object has been to show the disadvantages of present equipment, and to propose possible solutions for overcoming them: firstly by improving the methods used for collecting data, and the performances of the equipment doing the collecting; secondly by devising methods for processing the data so as to reduce image distortion and, first of all, the astigmatism due to the collimator. The first part deals with the study of the formation of the image by means of the collimating grid, the second with the examination of many systems which could be used for acquiring data. The last part summarizes the experiments carried out and proposes an experimental programme for the development of a prototype. (author) [fr

  15. Factors affecting the repeatability of gamma camera calibration for quantitative imaging applications using a sealed source

    International Nuclear Information System (INIS)

    Anizan, N; Wahl, R L; Frey, E C; Wang, H; Zhou, X C

    2015-01-01

    Several applications in nuclear medicine require absolute activity quantification of single photon emission computed tomography images. Obtaining a repeatable calibration factor that converts voxel values to activity units is essential for these applications. Because source preparation and measurement of the source activity using a radionuclide activity meter are potential sources of variability, this work investigated instrumentation and acquisition factors affecting repeatability using planar acquisition of sealed sources. The calibration factor was calculated for different acquisition and geometry conditions to evaluate the effect of the source size, lateral position of the source in the camera field-of-view (FOV), source-to-camera distance (SCD), and variability over time using sealed Ba-133 sources. A small region of interest (ROI) based on the source dimensions and collimator resolution was investigated to decrease the background effect. A statistical analysis with a mixed-effects model was used to evaluate quantitatively the effect of each variable on the global calibration factor variability. A variation of 1 cm in the measurement of the SCD from the assumed distance of 17 cm led to a variation of 1–2% in the calibration factor measurement using a small disc source (0.4 cm diameter) and less than 1% with a larger rod source (2.9 cm diameter). The lateral position of the source in the FOV and the variability over time had small impacts on calibration factor variability. The residual error component was well estimated by Poisson noise. Repeatability of better than 1% in a calibration factor measurement using a planar acquisition of a sealed source can be reasonably achieved. The best reproducibility was obtained with the largest source with a count rate much higher than the average background in the ROI, and when the SCD was positioned within 5 mm of the desired position. In this case, calibration source variability was limited by the quantum

  16. Evaluation of a high-resolution, breast-specific, small-field-of-view gamma camera for the detection of breast cancer

    International Nuclear Information System (INIS)

    Brem, R.F.; Kieper, D.A.; Rapelyea, J.A.; Majewski, S.

    2003-01-01

    Purpose: The purpose of our study is to review the state of the art in nuclear medicine imaging of the breast (scintimammography) and to evaluate a novel, high-resolution, breast-specific gamma camera (HRBGC) for the detection of suspicious breast lesions. Materials and Methods: Fifty patients with 58 breast lesions in whom a scintimammogram was clinically indicated were prospectively evaluated with a general-purpose gamma camera and a HRBGC prototype. Nuclear studies were prospectively classified as negative (normal/benign) or positive (suspicious/malignant) by two radiologists, blinded to mammographic and histologic results with both the conventional and high-resolution. All lesions were confirmed by pathology. Results: Included in this study were 30 benign and 28 malignant lesions. The sensitivity for detection of breast cancer was 64.3% (18/28) with the conventional camera and 78.6% (22/28) with the HRBGC. Specificity of both systems was 93.3% (28/30). In the 18 nonpalpable cancers, sensitivity was 55.5% (10/18) and 72.2% (13/18) with the general-purpose camera and HRBGC, respectively. In cancers ≤ 1cm, 7 of 15 were detected with the general-purpose camera and 10 of 15 with the HRBGC. Four of the cancers (median size, 8.5 mm) detected with the HRBGC were missed by the conventional camera Conclusion: Evaluation of indeterminate breasts lesions with a high resolution, breast-specific gamma camera results in improved sensitivity for the detection of cancer with greater improvement demonstrated in nonpalpable and ≤1 cm cancers

  17. Design and implementation of a quality assurance program for gamma cameras; Diseno e implementacion de un programa de aseguramiento de calidad para camaras gamma

    Energy Technology Data Exchange (ETDEWEB)

    Montoya M, A.; Rodriguez L, A. [Instituto Nacional de Cancerologia, Departamento de Medicina Nuclear, Av. San Fernando No. 22, Col. Seccion XVI, 14080 Mexico D. F. (Mexico); Trujillo Z, F. E., E-mail: montoya-moreno@hotmail.co [Hospital Regional de Alta Especialidad de Oaxaca, Area de Fisica Medica, Aldama s/n, Paraje El Tule, 71256 San Bartolo Coyotepec, Oaxaca (Mexico)

    2010-09-15

    In nuclear medicine more than 90% of the carried out procedures are diagnostic. To assure an appropriate diagnostic quality of the images and the doses optimization received by the patients originated in the radioactive material, it is indispensable the periodic surveillance of the operation and performance of the equipment s by means of quality assurance tests. This work presents a proposal of a quality assurance program for gamma cameras based on recommendations of the IAEA, the American Association of Medical Physics and the National Electrical Manufacturers Association. Some tests of the program were applied to an e.cam gamma camera (Siemens) of the Nuclear Medicine Department of the National Institute of Cancer. The intrinsic and extrinsic uniformity, the intrinsic spatial resolution and the extrinsic sensibility were verified. For intrinsic uniformity the average daily values of the integral uniformity and differential uniformity in the useful vision field were 2.61% and 1.58% respectively, the average monthly values of intrinsic uniformity for the integral and differential uniformity in the useful vision field were 4.10% and 1.66% respectively. The used acceptance criterions were respectively of 3.74% and 2.74%. The average values of extrinsic uniformity for the useful vision field were of 7.65% (intrinsic uniformity) and 2.69% (extrinsic uniformity), in this case the acceptance criterion is a value of 6.00%. The average value of intrinsic spatial resolution went 4.67 mm superior to 4.4. mm that is the acceptance limit. Finally, maximum variations of 1.8% were observed (minors than 2% that is the acceptance criterion) for the extrinsic sensibility measured in different regions of the detector. Significant variations of extrinsic sensibility were not observed among the monthly lectures. Of the realized measurements was concluded that the system requires of a maintenance service by part of the manufacturer, which one carries out later on to this work. The

  18. Quantitation of cerebral blood volume by 99mTc-DTPA-HSA SPECT

    International Nuclear Information System (INIS)

    Inoue, Yusuke; Machida, Kikuo; Momose, Toshimitsu

    1992-01-01

    The characteristics of technetium-99m diethylenetriaminepentaacetic acid human serum albumin ( 99m Tc-DTPA-HSA) as an agent for quantitation of cerebral blood volume (CBV) were examined. The radioactivity after decay correction as a percentage of the activity at 10 minutes was 84.3±1.3% at 120 minutes after the injection of 99m Tc-DTPA-HSA. Radioactivity was found exclusively in plasma, with little in blood cells. The blood retention of 99m Tc-DTPA-HSA is sufficient, and its use in the quantitation of CBV omits the need for centrifugation of the blood sample. CBV quantified using the tracer and a SPECT system with a single-head rotating gamma camera was 4.09±0.60 ml/100g brain, similar to values reported previously. Two serial SPECT scans provided similar images, and the CBV values determined by the two scans were closely correlated (p 99m Tc-DTPA-HSA has useful properties for quantitative CBV measurement and that quantitation of CBV by 99m Tc-DTPA-HSA SPECT is feasible using a system with a single-head rotating gamma camera. (author)

  19. Design and development of pixel size calibration phantom for gamma camera

    International Nuclear Information System (INIS)

    Khokhar, S.B.; Manan, A.; Chaudary, M.A.; Pervaiz, T.

    2005-01-01

    The purpose of the study is to make pixel calibration phantom, to measure pixel size for different zoom factors and matrix sizes and to compare the pixel size with the values of provided by the vendor. For this purpose pixel size calibration phantom (rectangular in shape) made up of acrylic material having dimension 43 x 10 square cm was prepared. Seven circular holes at exact known distance with whole diameter 1.5 mm were born. High specific activity was filled in the holes of the phantom, acquired the image by fixing the number of counts at all available matrices and zoom factors. Pixel size was calculated by counting the number of pixels between focused points and divided the distance thereof by the number of pixels. Mean pixel size was calculated and compared it with reference value provided by the manufacturer of the camera. P- value was calculated which showed that most results lie in the acceptable limit. The calculated values agreed very well. However there exist some deviation at larger matrix sizes, which might be due to scattering of radiation that overlaps nearest pixels, and due to human error. (author)

  20. Clinical evaluation of the Tl-201 ECG-gated myocardial SPECT

    International Nuclear Information System (INIS)

    Mochizuki, Teruhito

    1989-01-01

    In order to evaluate the clinical usefulness of the Tl-201 ECG-gated myocardial single photon emission computed tomography (SPECT), we compared the wall motion and the grade of the Tl-201 uptake of the ECG-gated myocardial SPECT with the wall motion of the ECG-gated blood pool SPECT. Materials were 87 patients of 50 old myocardial infarctions (OMIs), 19 hypertrophic cardiomyopathies (HCMs), 2 dilated cardiomyopathies (DCMs) and 16 others. After intravenous injection of 111-185 MBq (3-5 mCi) of Tl-201 at rest, the projection data were acquired using a rotating gamma-camera through 180deg, from RAO 45deg in 24 directions, each of which consisted of 80-100 beats. For the reconstruction of ED, ES and non-gated images, R-R interval was divided into about 20 (18-22) fractions. In 348 regions of interest (anterior, septal, lateral and inferior wall) in 87 cases, wall motion and the Tl-201 uptake were evaluated to three grades (normal, hypokinesis and akinesis; normal, low and defect, respectively), which were compared with the wall motion of the ECG-gated blood pool SPECT. The wall motion and the grade of the Tl-201 uptake of the ECG-gated myocardial SPECT correlated well with the wall motion of the ECG-gated blood pool SPECT (96.6% and 87.9%, respectively). In conclusion, the ECG-gated myocardial SPECT can provide clear perfusion images and is a very useful diagnostic strategy to evaluate the regional wall motion and perfusion simultaneously. (author)

  1. Silicon Detectors for PET and SPECT

    Science.gov (United States)

    Cochran, Eric R.

    Silicon detectors use state-of-the-art electronics to take advantage of the semiconductor properties of silicon to produce very high resolution radiation detectors. These detectors have been a fundamental part of high energy, nuclear, and astroparticle physics experiments for decades, and they hold great potential for significant gains in both PET and SPECT applications. Two separate prototype nuclear medicine imaging systems have been developed to explore this potential. Both devices take advantage of the unique properties of high resolution pixelated silicon detectors, designed and developed as part of the CIMA collaboration and built at The Ohio State University. The first prototype is a Compton SPECT imaging system. Compton SPECT, also referred to as electronic collimation, is a fundamentally different approach to single photon imaging from standard gamma cameras. It removes the inherent coupling of spatial resolution and sensitivity in mechanically collimated systems and provides improved performance at higher energies. As a result, Compton SPECT creates opportunities for the development of new radiopharmaceuticals based on higher energy isotopes as well as opportunities to expand the use of current isotopes such as 131I due to the increased resolution and sensitivity. The Compton SPECT prototype consists of a single high resolution silicon detector, configured in a 2D geometry, in coincidence with a standard NaI scintillator detector. Images of point sources have been taken for 99mTc (140 keV), 131I (364keV), and 22Na (511 keV), demonstrating the performance of high resolution silicon detectors in a Compton SPECT system. Filtered back projection image resolutions of 10 mm, 7.5 mm, and 6.7 mm were achieved for the three different sources respectively. The results compare well with typical SPECT resolutions of 5-15 mm and validate the claims of improved performance in Compton SPECT imaging devices at higher source energies. They also support the potential of

  2. Monitoring of the internal contamination of occupationally exposure personnel in services of nuclear medicine through the use of gamma cameras

    International Nuclear Information System (INIS)

    Teran, M.; Paolino, A.; Savio, E.; Hermida, J.C.; Dantas, B.M.

    2006-01-01

    The radionuclides incorporation can happen as a result of diverse activities; these include the work associated with the different stadiums of the nuclear fuel cycle, the use of radioactive sources in medicine, the scientific research, the agriculture and the industry. In Uruguay the main activities linked to the manipulation of open sources correspond those of Nuclear Medicine and from 2004, in the mark of the Project Arcal RLA 049 and being based on the Safety Guides of the IAEA it is implementing a program of internal monitoring in combined form the Nuclear Medicine Center of the Hospital of and the Radiochemistry class of the Faculty of Chemistry. In accordance with the publication of the ICRP 75 the emphasis of any monitoring program should be in the formal study of the doses in the workers to who are considered commendable of to receive in routine form an outstanding fraction of the dose limits or who work in areas where the exposures can be significant in the accident event. From April 2004, to the date has started a pilot plan by means of in that were established appropriate conditions of procedures and of safety in a reduced group of workers of the Nuclear Medicine area. In that period the first work limits, equipment adjustment, calibrations and registration systems were determined. The monitoring system implemented until the moment is carried out with a thyroid caption equipment. However these measurements are carried out in the university hospital embracing 40% of the involved workers of our country, with the purpose of reaching the covering of the biggest quantity of occupationally exposed personnel of private clinics. Also it was developed a new work proposal that allows to have an alternative measure method, in the event of not having the equipment habitually used. Among the conclusions of this work are that for the before exposed are considered the measure conditions but appropriate the following ones: Gamma Camera without collimator; Measurement

  3. First validation of myocardial flow reserve assessed by dynamic 99mTc-sestamibi CZT-SPECT camera: head to head comparison with 15O-water PET and fractional flow reserve in patients with suspected coronary artery disease. The WATERDAY study.

    Science.gov (United States)

    Agostini, Denis; Roule, Vincent; Nganoa, Catherine; Roth, Nathaniel; Baavour, Raphael; Parienti, Jean-Jacques; Beygui, Farzin; Manrique, Alain

    2018-07-01

    We assessed the feasibility of myocardial blood flow (MBF) and flow reserve (MFR) estimation using dynamic SPECT with a novel CZT camera in patients with stable CAD, in comparison with 15 O-water PET and fractional flow reserve (FFR). Thirty patients were prospectively included and underwent FFR measurements in the main coronary arteries (LAD, LCx, RCA). A stenosis ≥50% was considered obstructive and a FFR abnormal if ≤0.8. All patients underwent a dynamic rest/stress 99m Tc-sestamibi CZT-SPECT and 15 O-water PET for MBF and MFR calculation. Net retention kinetic modeling was applied to SPECT data to estimate global uptake values, and MBF was derived using Leppo correction. Ischemia by PET and CZT-SPECT was considered present if MFR was lower than 2 and 2.1, respectively. CZT-SPECT yielded higher stress and rest MBF compared to PET for global and LAD and LCx territories, but not in RCA territory. MFR was similar in global and each vessel territory for both modalities. The sensitivity, specificity, accuracy, positive and negative predictive value of CZT-SPECT were, respectively, 83.3, 95.8, 93.3, 100 and 85.7% for the detection of ischemia and 58.3, 84.6, 81.1, 36.8 and 93% for the detection of hemodynamically significant stenosis (FFR ≤ 0.8). Dynamic 99m Tc-sestamibi CZT-SPECT was technically feasible and provided similar MFR compared to 15 O-water PET and high diagnostic value for detecting impaired MFR and abnormal FFR in patients with stable CAD.

  4. Emission computed tomography using rotating gamma cameras for stress 201Tl myocardial imaging

    International Nuclear Information System (INIS)

    Takeda, Kan; Maeda, Hisato; Nakagawa, Tsuyoshi; Yamaguchi, Nobuo; Taguchi, Mitsuo

    1983-01-01

    The purpose of this study is to evaluate the efficacy of emission computed tomography (ECT) for stress 201 Tl myocardial imaging to localize coronary artery disease (CAD) in comparison with planar (PL) images. In a series of 14 normal subjects and 53 patients with CAD proved coronary arteriography, ECT and PL imaging were performed successively. ECT data were collected for 90 projections in a 64 x 64 matrix form with a total aquisition time of 6 munutes over 180 0 of opposed dual cameras ratation and tomographic sections oriented perpendicular and parallel to the long axis of left ventricle were reconstructed. PL images were obtained for left lateral, left anterior oblique (30 0 and 45 0 ) and anterior projections. Both ECT and PL myocardial images were divided into 8 segments and segmental analysis was performed by visual interpretation. The ECT images remarkably increased sensitivity over the PL images in left anterior descending (LAD) artery (from 56% to 76%), right coronary artery (RCA) (from 50% to 96%), and circumflex artery (CX) (from 56% to 69%) lesions. The specificity for ECT images, as compared with PL images, was higher in LAD (88% against 85%) but slightly lower in RCA (70% ag ainst 72%) and CX (84% against 88%). Overall accuracy, therefore, was improved in LAD (from 67% to 81%) and RCA (from 64% to 79%) but equal in CX (81%). We conclude that stress 201 Tl ECT imaging result in a remarkable improvement in the localization of CAD, especially in patients with RCA lesions and multi-vessel disease. (author)

  5. Clinical applications of SPECT-CT

    Energy Technology Data Exchange (ETDEWEB)

    Ahmadzadehfar, Hojjat; Biersack, Hans-Juergen (eds.) [University Hospital Bonn (Germany). Dept. of Nuclear Medicine

    2014-06-01

    Covers the full spectrum of clinical applications of SPECT/CT in diagnosis of benign and malignant diseases. Includes chapters on the use of SPECT/CT for dosimetry and for therapy planning. Completely up to date. Many helpful illustrations. SPECT/CT cameras have considerably improved diagnostic accuracy in recent years. Such cameras allow direct correlation of anatomic and functional information, resulting in better localization and definition of scintigraphic findings. In addition to this anatomic referencing, CT coregistration provides superior quantification of radiotracer uptake based on the attenuation correction capabilities of CT. Useful applications of SPECT/CT have been identified not only in oncology but also in other specialties such as orthopedics and cardiology. This book covers the full spectrum of clinical applications of SPECT/CT in diagnosis and therapy planning of benign and malignant diseases. Opening chapters discuss the technology and physics of SPECT/CT and its use for dosimetry. The role of SPECT/CT in the imaging of a range of pathologic conditions is then addressed in detail. Applications covered include, among others, imaging of the thyroid, bone, and lungs, imaging of neuroendocrine tumors, cardiac scintigraphy, and sentinel node scintigraphy. Individual chapters are also devoted to therapy planning in selective internal radiation therapy of liver tumors and bremsstrahlung SPECT/CT. Readers will find this book to be an essential and up-to-date source of information on this invaluable hybrid imaging technique.

  6. Experimental MRI-SPECT insert system with Hybrid Semiconductor detectors Timepix for MR animal scanner Bruker 47/20

    Czech Academy of Sciences Publication Activity Database

    Zajíček, J.; Burian, M.; Soukup, P.; Novák, Vladimír; Macko, M.; Jakůbek, J.

    2017-01-01

    Roč. 12, January (2017), č. článku P01015. ISSN 1748-0221 Institutional support: RVO:68378297 Keywords : Gamma camera * SPECT * PET PET /CT * coronary CT angiography (CTA) * Gamma detectors (scintillators, CZT, HPG, HgI etc) * multi-modality systems * pixelated detectors and associated VLSI electronics Subject RIV: JB - Sensors, Measurment, Regulation OBOR OECD: Electrical and electronic engineering Impact factor: 1.220, year: 2016 http://iopscience.iop.org/article/10.1088/1748-0221/12/01/P01015

  7. The clinical use of brain SPECT imaging in neuropsychiatry

    International Nuclear Information System (INIS)

    Amen, Daniel G; Wu, Joseph C; Carmichael, Blake

    2003-01-01

    This article reviews the literature on brain SPECT imaging in brain trauma, dementia, and temporal lobe epilepsy. Brain SPECT allows clinicians the ability to view cerebral areas of healthy, low, and excessive perfusion. This information can be correlated with what is known about the function or dysfunction of each area. SPECT has a number of advantages over other imaging techniques, including wider availability, lower cost, and high quality resolution with multi-headed cameras. There are a number of issues that compromise the effective use of SPECT, including low quality of some imaging cameras, and variability of image rendering and readings (Au)

  8. Brain SPECT with 123I-isopropyl amphetamine in epilepsy

    International Nuclear Information System (INIS)

    Biersack, H.J.; Reske, S.N.; Rasche, A.; Reichmann, K.; Winkler, C.

    1983-01-01

    Ten patients were studied with N-isopropyl I-123 p-iodoamphetamine. Single photon emission computed tomography (SPECT) was carried out by hand of a rotating gamma camera system (Gammatome T9000/CGR, high resolution collimator). During 1 rotation (360 0 ) 64 frames (4k matrix) were acquired within 20 min 1 hour after injection of 6.5 mCi I-123 labeled amphetamine. The content of I-124 was less than 2%. After reconstruction of transverse slices coronar and sagittal reconstructions were rapidly performed using an array processor. Nine patients suffered from epilepsy and one from severe migraine. Excellent differentiation between gray and white matter of the cerebral cortex and the basal ganglia was evident in all of the cases. In 2 out of 3 patients with epilepsy and negative CT results SPECT revealed circumscribed areas with increased amphetamine uptake in accordance with the EEG findings. In 4 out of 6 cases with positive CT findings SPECT lesions with diminished amphetamine uptake could be established. One patient with severe migraine showed focal increased amphetamine uptake in accordance with the respective clinical results. (orig.)

  9. Pre-chemotherapy values for left and right ventricular volumes and ejection fraction by gated tomographic radionuclide angiography using a cadmium-zinc-telluride detector gamma camera

    DEFF Research Database (Denmark)

    Haarmark, Christian; Haase, Christine; Jensen, Maria Maj

    2016-01-01

    age and both left and right ventricular volumes in women (r = -0.4, P right end systolic ventricular volume in men (r = -0.3, P = .001). CONCLUSION: A set of reference values for cardiac evaluation prior to chemotherapy in cancer patients without other known cardiopulmonary......BACKGROUND: Estimation of left ventricular ejection fraction (LVEF) using equilibrium radionuclide angiography is an established method for assessment of left ventricular function. The purpose of this study was to establish normative data on left and right ventricular volumes and ejection fraction......, using cadmium-zinc-telluride SPECT camera. METHODS AND RESULTS: From routine assessments of left ventricular function in 1172 patients, we included 463 subjects (194 men and 269 women) without diabetes, previous potentially cardiotoxic chemotherapy, known cardiovascular or pulmonary disease. The lower...

  10. Reliability of single kidney glomerular filtration rate measured by a 99mTc-DTPA gamma camera technique

    International Nuclear Information System (INIS)

    Rehling, M.; Moller, M.L.; Jensen, J.J.; Thamdrup, B.; Lund, J.O.; Trap-Jensen, J.

    1986-01-01

    The reliability of a previously published method for determination of single kidney glomerular filtration rate (SKGFR) by means of technetium-99m-diethylenetriaminepenta-acetate (99mTc-DTPA) gamma camera renography was evaluated. The day-to-day variation in the calculated SKGFR values was earlier found to be 8.8%. The technique was compared to the simultaneously measured renal clearance of inulin in 19 unilaterally nephrectomized patients with GFR varying from 11 to 76 ml/min. The regression line (y = 1.04 X -2.5) did not differ significantly from the line of identity. The standard error of estimate was 4.3 ml/min. In 17 patients the inter- and intraobserver variation of the calculated SKGFR values was 1.2 ml/min and 1.3 ml/min, respectively. In 21 of 25 healthy subjects studied (age range 27-29 years), total GFR calculated from the renograms was within an established age-dependent normal range of GFR

  11. Non-invasive estimation of the human pulmonary blood volume with gamma camera and RI-angiocardiography

    International Nuclear Information System (INIS)

    Goto, Koshi; Hirano, Akihiko; Hirakawa, Senri

    1981-01-01

    A new, non-invasive method for the estimation of the human pulmonary blood volume (PBV), existing between the pulmonary artery bifurcation (PAB) and the left atrium (LA), has been developed in this laboratory, in the form of PBV = PPT sub(RCG) x 0.77 x CO, equation (6), given in Appendix. This was an extension of the classical Stewart-Hamilton method of indicator dilution, applied to radioisotope angiocardiography. Using a gamma-camera, the radio-isotope (99 m Tc-albumin) dilution curves were recorded externally at the region of PAB, LA and LV (left ventricle), among other things, in human subjects in supine position. The mean transit time (MTT) was determined for each region, and the difference in MTT, e.g., ΔMTT sub(PAB-LA), was measured. We calculated PBV between PAB and LA as PBV = ΔMTT sub(PAB-LA) x CO, equation (1) given in Appendix. Empirical time relations between ΔMTT sub(PAB-LA) and PPT sub(RCG) were examined in mechanical models and human subjects, through several steps represented by equations (2) to (5), given in Appendix, and our tentatively final formula was equation (6). The values of PBV estimated in this way were in good agreement with those of PBV measured invasively in the past, using two injection sites (PA and LA) and one sampling site (artery). (author)

  12. Functional studies of the oesophagus with sulfur-colloid of sup(99m)Tc and gamma-camera

    International Nuclear Information System (INIS)

    Veiga-Fernandes, F.; Costa, P.M.; Pinheiro, M.F.; Guerreiro, D.

    1982-01-01

    A scintiscanning technique which allows sequential detection and quantification of gastro-oesophageal reflux (GER), and study of the oesophageal emptying of a liquid and semi-solid food is presented. At first patients swallowed 5 ml of water containing 1 mCi sup(99m)Tc sulfur-colloid and oesophageal activity is recorded from an anterior view by a gamma-camera. Then, patients ingest 300 ml of water that clear the oesophagus and fill up the stomach. GER index is calculated according to the formula GER = (Ae - Ab)/Ag) x 100, where Ae is the activity in the oesophagus; Ab, is the background activity; and Ag is the gastric activity. GER index presented corresponds to a median of three determinations in upright, supine and supine position with abdominal pressure of 4 kilos. The oesophageal transit time of a semi-solid food in upright and supine position is registered 5 minutes after GER studies through two areas of interest which are positioned: one in the superior third and the other in the inferior third of the oesophagus. Normal GER reflux index was, 0.84 +- 0.37 in the upright position; 0.87 +- 0.43 in the supine position; and 0.90 +- 0.56 in the supine position plus abdominal pressure

  13. Assessment of spleen size using gamma camera scintigraphy in newly diagnosed patients with essential thrombocythaemia and polycythaemia vera

    International Nuclear Information System (INIS)

    Carneskog, J.; Wadenvik, H.; Kutti, J.; Fjaeelling, M.

    1996-01-01

    By using gamma camera imaging the spleen size was assessed in 18 consecutive patients with essential thrombocythaemia (ET) and in 18 consecutive patients with polycythaemia vera (PV). All ET and PV patients were newly diagnosed and had not received any myelosuppressive therapy prior to study. The spleen areas in both posterior and left lateral projections were determined. Eighteen consecutive patients with idiopathic thrombocytopenic purpura (ITP) served as a control group since by definition they do not present with splenic enlargement; in these latter subjects the mean posterior and left lateral splenic areas were almost identical (48 ± 15 and 47 ± 17 cm 2 , respectively). In comparison with this control group patients with ET an dPV had significantly larger spleens. In both ET and in PV patients the left lateral spleen scan area exceeded the posterior one. Patients with PV had larger splenic areas in both projections than did patients with ET, but the differences were not statistically significant. Compared to the ITP patients it was found that at least 50% of the ET patients and at least 61% of the PV patients at diagnosis presented with splenomegaly. (au) 35 refs

  14. Assessment of spleen size using gamma camera scintigraphy in newly diagnosed patients with essential thrombocythaemia and polycythaemia vera

    Energy Technology Data Exchange (ETDEWEB)

    Carneskog, J.; Wadenvik, H.; Kutti, J. [Univ. of Goeteborg, Sahlgrenska Univ. Hospital, Dept. of Medicine, Haematology Section, Goeteborg (Sweden); Fjaeelling, M. [Univ. of Goeteborg, Sahlgrenska Univ. Hospital, Dept. of Clinical Physiology, Section of Nuclear Med., Goeteborg (Sweden)

    1996-03-01

    By using gamma camera imaging the spleen size was assessed in 18 consecutive patients with essential thrombocythaemia (ET) and in 18 consecutive patients with polycythaemia vera (PV). All ET and PV patients were newly diagnosed and had not received any myelosuppressive therapy prior to study. The spleen areas in both posterior and left lateral projections were determined. Eighteen consecutive patients with idiopathic thrombocytopenic purpura (ITP) served as a control group since by definition they do not present with splenic enlargement; in these latter subjects the mean posterior and left lateral splenic areas were almost identical (48 {+-} 15 and 47 {+-} 17 cm{sup 2}, respectively). In comparison with this control group patients with ET an dPV had significantly larger spleens. In both ET and in PV patients the left lateral spleen scan area exceeded the posterior one. Patients with PV had larger splenic areas in both projections than did patients with ET, but the differences were not statistically significant. Compared to the ITP patients it was found that at least 50% of the ET patients and at least 61% of the PV patients at diagnosis presented with splenomegaly. (au) 35 refs.

  15. Intraoperative Scintigraphy Using a Large Field-of-View Portable Gamma Camera for Primary Hyperparathyroidism: Initial Experience

    Directory of Open Access Journals (Sweden)

    Nathan C. Hall

    2015-01-01

    Full Text Available Background. We investigated a novel technique, intraoperative 99 mTc-Sestamibi (MIBI imaging (neck and excised specimen (ES, using a large field-of-view portable gamma camera (LFOVGC, for expediting confirmation of MIBI-avid parathyroid adenoma removal. Methods. Twenty patients with MIBI-avid parathyroid adenomas were preoperatively administered MIBI and intraoperatively imaged prior to incision (neck and immediately following resection (neck and/or ES. Preoperative and intraoperative serum parathyroid hormone monitoring (IOPTH and pathology (path were also performed. Results. MIBI neck activity was absent and specimen activity was present in 13/20 with imaging after initial ES removal. In the remaining 7/20 cases, residual neck activity and/or absent ES activity prompted excision of additional tissue, ultimately leading to complete hyperfunctioning tissue excision. Postexcision LFOVGC ES imaging confirmed parathyroid adenoma resection 100% when postresection imaging qualitatively had activity (ES and/or no activity (neck. The mean ± SEM time saving using intraoperative LFOVGC data to confirm resection versus first IOPTH or path result would have been 22.0 ± 2 minutes (specimen imaging and 26.0 ± 3 minutes (neck imaging. Conclusion. Utilization of a novel real-time intraoperative LFOVGC imaging approach can provide confirmation of MIBI-avid parathyroid adenoma removal appreciably faster than IOPTH and/or path and may provide a valuable adjunct to parathyroid surgery.

  16. Imaging fusion (SPECT/CT) in degenerative disease of spine

    International Nuclear Information System (INIS)

    Bernal, P.; Ucros, G.; Bermudez, S.; Ocampo, M.

    2007-01-01

    Full text: Objective: To determine the utility of Fusion Imaging SPECT/CT in degenerative pathology of the spine and to establish the impact of the use of fusion imaging in spinal pain due to degenerative changes of the spine. Materials and methods: 44 Patients (M=21, F=23) average age of 63 years and with degenerative pathology of spine were sent to Diagnosis Imaging department in FSFB. Bone scintigraphy (SPECT), CT of spine (cervical: 30%, Lumbar 70%) and fusion imaging were performed in all of them. Bone scintigraphy was carried out in a gamma camera Siemens Diacam double head attached to ESOFT computer. The images were acquired in matrix 128 x 128, 20 seg/imag, 64 images. CT of spine was performed same day or two days after in Helycoidal Siemens somatom emotion CT. The fusion was done in a Dicom workstation in sagital, axial and coronal reconstruction. The findings were evaluated by 2 Nuclear Medicine physicians and 2 radiologists of the staff of FSFB in an independent way. Results: Bone scan (SPECT) and CT of 44 patients were evaluated. CT showed facet joint osteoarthrities in 27 (61.3%) patients, uncovertebral joint arthrosis in 7 (15.9%), bulging disc in 9(20.4%), spinal nucleus lesion in 7(15.9%), osteophytes in 9 (20.4%), spinal foraminal stenosis in 7 (15.9%), spondylolysis/spondylolisthesis in 4 (9%). Bone scan showed facet joint osteoarthrities in 29 (65.9%), uncovertebral joint arthrosis in 4 (9%), osteophytes in 9 (20.4%) and normal 3 (6.8%). The imaging fusion showed coincidence findings (main lesion in CT with high uptake in scintigraphy) in 34 patients (77.2%) and no coincidence in 10 (22.8%). In 15 (34.09%) patients the fusion provided additional information. The analysis of the findings of CT and SPECT showed similar results in most of the cases and the fusion didn't provide additional information but it allowed to confirm the findings but when the findings didn't match where the CT showed several findings and SPECT only one area with high uptake

  17. Angiocardiography with 99mTc-albumin bymass of gamma camera associated with examinations in the morphological and dynamic study of the congenital heart disease

    Energy Technology Data Exchange (ETDEWEB)

    Esposti, A D; Abbati, A

    1975-03-03

    A. Degli Esposti and A. Abbati: Computerised gamma-camera 99/sup m/ Tc-albumin angiocardiography in the morphological and dynamic examination of children with congenital heart disease. A number of cases in which computerised gamma-camera 99/sup m/ Tc-albumin angiocardiography was employed in children with congenital heart diseases are described. Comparison is made with the data obtained contrastographically, or during surgery or necropsy. The preliminary results, particularly in recently examined subjects, whose data were processed in a more efficient manner, point to the usefulness of the method. Though incapable of offering the same morphological precision as contrastography, it has the advantage of being absolute harmless and, above all, repeatable.

  18. Waste reduction efforts through the evaluation and procurement of a digital camera system for the Alpha-Gamma Hot Cell Facility at Argonne National Laboratory-East

    International Nuclear Information System (INIS)

    Bray, T. S.; Cohen, A. B.; Tsai, H.; Kettman, W. C.; Trychta, K.

    1999-01-01

    The Alpha-Gamma Hot Cell Facility (AGHCF) at Argonne National Laboratory-East is a research facility where sample examinations involve traditional photography. The AGHCF documents samples with photographs (both Polaroid self-developing and negative film). Wastes generated include developing chemicals. The AGHCF evaluated, procured, and installed a digital camera system for the Leitz metallograph to significantly reduce labor, supplies, and wastes associated with traditional photography with a return on investment of less than two years

  19. [Evaluation of the efficacy of sentinel node detection in breast cancer: chronological course and influence of the incorporation of an intra-operative portable gamma camera].

    Science.gov (United States)

    Goñi Gironés, E; Vicente García, F; Serra Arbeloa, P; Estébanez Estébanez, C; Calvo Benito, A; Rodrigo Rincón, I; Camarero Salazar, A; Martínez Lozano, M E

    2013-01-01

    To define the sentinel node identification rate in breast cancer, the chronological evolution of this parameter and the influence of the introduction of a portable gamma camera. A retrospective study was conducted using a prospective database of 754 patients who had undergone a sentinel lymph node biopsy between January 2003 and December 2011. The technique was mixed in the starting period and subsequently was performed with radiotracer intra-peritumorally administered the day before of the surgery. Until October 2009, excision of the sentinel node was guided by a probe. After that date, a portable gamma camera was introduced for intrasurgical detection. The SN was biopsied in 725 out of the 754 patients studied. The resulting technique global effectiveness was 96.2%. In accordance with the year of the surgical intervention, the identification percentage was 93.5% in 2003, 88.7% in 2004, 94.3% in 2005, 95.7% in 2006, 93.3% in 2007, 98.8% in 2008, 97.1% in 2009 and 99.1% in 2010 and 2011. There was a significant difference in the proportion of identification before and after the incorporation of the portable gamma camera of 4.6% (95% CI of the difference 2-7.2%, P = 0.0037). The percentage of global identification exceeds the recommended level following the current guidelines. Chronologically, the improvement for this parameter during the study period has been observed. These data suggest that the incorporation of a portable gamma camera had an important role. Copyright © 2013 Elsevier España, S.L. and SEMNIM. All rights reserved.

  20. Measuring of main parameters of blood circulation at small laboratory animals in chronic experiment by means of computerized gamma-camera

    International Nuclear Information System (INIS)

    Rutskij, A.V.; Kovalenko, Yu.D.; Rudenko, F.V.; Ioda, G.I.; Kaminskij, M.P.

    1996-01-01

    Technique for studding of a state systemic and regional hemodynamics at small laboratory animals (rats) by using short-lived isotopes (technetium 99 m) and computerized gamma-camera are described. One gives possibility to make the repeated measuring in condition long-tome experiment. The proposed technique of radiocardiocirculography gives possibility simultaneously to measure linear parameters of both arterial and vein blood circulation too. 3 refs., 1 tab., 2 figs

  1. Reference Range of Functional Data of Gated Myocardial Perfusion SPECT by Quantitative Gated SPECT of Cedars-Sinai and 4D-MSPECT of Michigan University

    Energy Technology Data Exchange (ETDEWEB)

    Kang, Do Young; Kim, Moo Hyun; Kim, Young Dae [College of Medicine, Univ. of Donga, Pusan (Korea, Republic of)

    2003-07-01

    Various programs have been developed for gating of myocardial perfusion SPECT. Among the those program, the most popular program is the Quantitative Gated SPECT (QGS)? developed by Cedars-Sinai hospital and most recently released program is 4D-MSPECT? developed by university of Michigan. It is important to know the reference range of the functional data of gated myocardial perfusion SPECT because it is necessary to determine abnormality of individual patient and echocardiographic data is different from those of gated SPECT. Tc-99m MIBI gated myocardial perfusion SPECT image was reconstructed by dual head gamma camera (Siemens, BCAM, esoft) as routine procedure and analyzed using QGS? and 4D-MSPECT? program. All patients (M: F=9: 18, Age 69{+-}9 yrs) showed normal myocardial perfusion. The patients with following characteristics were excluded: previous angina or MI history, ECG change with Q wave or ST-T change, diabetes melitius, hypercholesterolemia, typical chest pain, hypertension and cardiomyopathy. Pre-test likelihood of all patients was low. (1) In stress gated SPECT by QGS?, EDV was 73{+-}25 ml, ESV 25{+-}14 ml, EF 67{+-}11 % and area of first frame of gating 106.4{+-}21cm{sup 2}. In rest gated SPECT, EDV was 76{+-}26 ml, ESV 27{+-}15 ml, EF 66{+-}12 and area of first frame of gating 108{+-}20cm{sup 2}. (2) In stress gated SPECT by 4D-MSPECT?, EDV was 76{+-}28 ml, ESV 23{+-}16 ml, EF 72{+-}11 %, mass 115{+-}24 g and ungated volume 42{+-}15 ml. In rest gated SPECT, EDV was 75{+-}27 ml, ESV 23{+-}12 ml, EF 71{+-}9%, mass 113{+-}25g and ungate dvolume 42{+-}15 ml, (3) s-EDV, s-EF, r-ESV and r-EF were significantly different between QGS? and 4D-MSPECT? (each p=0.016, p<0.001. p=0.003 and p=0.001). We determined the normal reference range of functional parameters by QGS? and 4D-MSPECT? program to diagnose individually the abnormality of patients. And the reference ranges have to adopted to be patients by each specific gating program.

  2. Quantitative investigation of a novel small field of view hybrid gamma camera (HGC) capabil