WorldWideScience

Sample records for functional integral approaches

  1. Integration a functional approach

    CERN Document Server

    Bichteler, Klaus

    1998-01-01

    This book covers Lebesgue integration and its generalizations from Daniell's point of view, modified by the use of seminorms. Integrating functions rather than measuring sets is posited as the main purpose of measure theory. From this point of view Lebesgue's integral can be had as a rather straightforward, even simplistic, extension of Riemann's integral; and its aims, definitions, and procedures can be motivated at an elementary level. The notion of measurability, for example, is suggested by Littlewood's observations rather than being conveyed authoritatively through definitions of (sigma)-algebras and good-cut-conditions, the latter of which are hard to justify and thus appear mysterious, even nettlesome, to the beginner. The approach taken provides the additional benefit of cutting the labor in half. The use of seminorms, ubiquitous in modern analysis, speeds things up even further. The book is intended for the reader who has some experience with proofs, a beginning graduate student for example. It might...

  2. CLARM: An integrative approach for functional modules discovery

    KAUST Repository

    Salem, Saeed M.

    2011-01-01

    Functional module discovery aims to find well-connected subnetworks which can serve as candidate protein complexes. Advances in High-throughput proteomic technologies have enabled the collection of large amount of interaction data as well as gene expression data. We propose, CLARM, a clustering algorithm that integrates gene expression profiles and protein protein interaction network for biological modules discovery. The main premise is that by enriching the interaction network by adding interactions between genes which are highly co-expressed over a wide range of biological and environmental conditions, we can improve the quality of the discovered modules. Protein protein interactions, known protein complexes, and gene expression profiles for diverse environmental conditions from the yeast Saccharomyces cerevisiae were used for evaluate the biological significance of the reported modules. Our experiments show that the CLARM approach is competitive to wellestablished module discovery methods. Copyright © 2011 ACM.

  3. Polymer density functional approach to efficient evaluation of path integrals

    DEFF Research Database (Denmark)

    Brukhno, Andrey; Vorontsov-Velyaminov, Pavel N.; Bohr, Henrik

    2005-01-01

    A polymer density functional theory (P-DFT) has been extended to the case of quantum statistics within the framework of Feynman path integrals. We start with the exact P-DFT formalism for an ideal open chain and adapt its efficient numerical solution to the case of a ring. We show that, similarly......, the path integral problem can, in principle, be solved exactly by making use of the two-particle pair correlation function (2p-PCF) for the ends of an open polymer, half of the original. This way the exact data for one-dimensional quantum harmonic oscillator are reproduced in a wide range of temperatures......-consistent iteration so as to correctly account for the interparticle interactions. The algorithm is speeded up by taking convolutions with the aid of fast Fourier transforms. We apply this approximate path integral DFT (PI-DFT) method to systems within spherical symmetry: 3D harmonic oscillator, atoms of hydrogen...

  4. Functional integral approach to the kinetic theory of inhomogeneous systems

    Science.gov (United States)

    Fouvry, Jean-Baptiste; Chavanis, Pierre-Henri; Pichon, Christophe

    2016-10-01

    We present a derivation of the kinetic equation describing the secular evolution of spatially inhomogeneous systems with long-range interactions, the so-called inhomogeneous Landau equation, by relying on a functional integral formalism. We start from the BBGKY hierarchy derived from the Liouville equation. At the order 1 / N, where N is the number of particles, the evolution of the system is characterised by its 1-body distribution function and its 2-body correlation function. Introducing associated auxiliary fields, the evolution of these quantities may be rewritten as a traditional functional integral. By functionally integrating over the 2-body autocorrelation, one obtains a new constraint connecting the 1-body DF and the auxiliary fields. When inverted, this constraint allows us to obtain the closed non-linear kinetic equation satisfied by the 1-body distribution function. This derivation provides an alternative to previous methods, either based on the direct resolution of the truncated BBGKY hierarchy or on the Klimontovich equation. It may turn out to be fruitful to derive more accurate kinetic equations, e.g., accounting for collective effects, or higher order correlation terms.

  5. The functions of autobiographical memory: an integrative approach.

    Science.gov (United States)

    Harris, Celia B; Rasmussen, Anne S; Berntsen, Dorthe

    2014-01-01

    Recent research in cognitive psychology has emphasised the uses, or functions, of autobiographical memory. Theoretical and empirical approaches have focused on a three-function model: autobiographical memory serves self, directive, and social functions. In the reminiscence literature other taxonomies and additional functions have been postulated. We examined the relationships between functions proposed by these literatures, in order to broaden conceptualisations and make links between research traditions. In Study 1 we combined two measures of individual differences in the uses of autobiographical memory. Our results suggested four classes of memory functions, which we labelled Reflective, Generative, Ruminative, and Social. In Study 2 we tested relationships between our four functions and broader individual differences, and found conceptually consistent relationships. In Study 3 we found that memories cued by Generative and Social functions were more emotionally positive than were memories cued by Reflective and Ruminative functions. In Study 4 we found that reported use of Generative functions increased across the lifespan, while reported use of the other three functions decreased. Overall our findings suggest a broader view of autobiographical memory functions that links them to ways in which people make meaning of their selves, their environment, and their social world more generally.

  6. Sensorimotor integration for functional recovery and the Bobath approach.

    Science.gov (United States)

    Levin, Mindy F; Panturin, Elia

    2011-04-01

    Bobath therapy is used to treat patients with neurological disorders. Bobath practitioners use hands-on approaches to elicit and reestablish typical movement patterns through therapist-controlled sensorimotor experiences within the context of task accomplishment. One aspect of Bobath practice, the recovery of sensorimotor function, is reviewed within the framework of current motor control theories. We focus on the role of sensory information in movement production, the relationship between posture and movement and concepts related to motor recovery and compensation with respect to this therapeutic approach. We suggest that a major barrier to the evaluation of the therapeutic effectiveness of the Bobath concept is the lack of a unified framework for both experimental identification and treatment of neurological motor deficits. More conclusive analysis of therapeutic effectiveness requires the development of specific outcomes that measure movement quality.

  7. State feedback integral control for a rotary direct drive servo valve using a Lyapunov function approach.

    Science.gov (United States)

    Yu, Jue; Zhuang, Jian; Yu, Dehong

    2015-01-01

    This paper concerns a state feedback integral control using a Lyapunov function approach for a rotary direct drive servo valve (RDDV) while considering parameter uncertainties. Modeling of this RDDV servovalve reveals that its mechanical performance is deeply influenced by friction torques and flow torques; however, these torques are uncertain and mutable due to the nature of fluid flow. To eliminate load resistance and to achieve satisfactory position responses, this paper develops a state feedback control that integrates an integral action and a Lyapunov function. The integral action is introduced to address the nonzero steady-state error; in particular, the Lyapunov function is employed to improve control robustness by adjusting the varying parameters within their value ranges. This new controller also has the advantages of simple structure and ease of implementation. Simulation and experimental results demonstrate that the proposed controller can achieve higher control accuracy and stronger robustness. Copyright © 2014 ISA. Published by Elsevier Ltd. All rights reserved.

  8. Integrating Formal and Functional Approaches to Language Teaching in French Immersion: An Experimental Study.

    Science.gov (United States)

    Day, Elaine M.; Shapson, Stan M.

    2001-01-01

    Evaluated the effect on French language proficiency of an integrated formal, analytic and functional, communicative approach to second language teaching in the immersion classroom. Impetus for the study arises from previous research indicating that immersion children show persistent weaknesses in their grammatical skills despite the fluent,…

  9. Functional Integral Approach to Transition Temperature of a Homogeneous Imperfect Bose Gas

    Institute of Scientific and Technical Information of China (English)

    HU Guang-Xi; DAI Xian-Xi; DAI Ji-Xin; William E. Evenson

    2004-01-01

    A functional integral approach (FIA) is introduced to calculate the transition temperature of a uniform imperfect Bose gas. With this approach we find that the transition temperature is higher than that of the corresponding ideal gas. We obtain the expression of the transition temperature shift as △Tc/To = 2.492 (na3) 1/6, where n is the density of particle number and a is the scattering length. The result has never been reported in the literature.

  10. An Approach for Integrating the Prioritization of Functional and Nonfunctional Requirements

    Directory of Open Access Journals (Sweden)

    Mohammad Dabbagh

    2014-01-01

    Full Text Available Due to the budgetary deadlines and time to market constraints, it is essential to prioritize software requirements. The outcome of requirements prioritization is an ordering of requirements which need to be considered first during the software development process. To achieve a high quality software system, both functional and nonfunctional requirements must be taken into consideration during the prioritization process. Although several requirements prioritization methods have been proposed so far, no particular method or approach is presented to consider both functional and nonfunctional requirements during the prioritization stage. In this paper, we propose an approach which aims to integrate the process of prioritizing functional and nonfunctional requirements. The outcome of applying the proposed approach produces two separate prioritized lists of functional and non-functional requirements. The effectiveness of the proposed approach has been evaluated through an empirical experiment aimed at comparing the approach with the two state-of-the-art-based approaches, analytic hierarchy process (AHP and hybrid assessment method (HAM. Results show that our proposed approach outperforms AHP and HAM in terms of actual time-consumption while preserving the quality of the results obtained by our proposed approach at a high level of agreement in comparison with the results produced by the other two approaches.

  11. Pathprinting: An integrative approach to understand the functional basis of disease.

    Science.gov (United States)

    Altschuler, Gabriel M; Hofmann, Oliver; Kalatskaya, Irina; Payne, Rebecca; Ho Sui, Shannan J; Saxena, Uma; Krivtsov, Andrei V; Armstrong, Scott A; Cai, Tianxi; Stein, Lincoln; Hide, Winston A

    2013-01-01

    New strategies to combat complex human disease require systems approaches to biology that integrate experiments from cell lines, primary tissues and model organisms. We have developed Pathprint, a functional approach that compares gene expression profiles in a set of pathways, networks and transcriptionally regulated targets. It can be applied universally to gene expression profiles across species. Integration of large-scale profiling methods and curation of the public repository overcomes platform, species and batch effects to yield a standard measure of functional distance between experiments. We show that pathprints combine mouse and human blood developmental lineage, and can be used to identify new prognostic indicators in acute myeloid leukemia. The code and resources are available at http://compbio.sph.harvard.edu/hidelab/pathprint.

  12. Functional Integral Approach to the Transition Temperature of Attractive Interacting Bose Gas in Traps

    Institute of Scientific and Technical Information of China (English)

    HU Guang-Xi; DAI Xian-Xi

    2004-01-01

    The functional integral approach (FIA) is introduced to study the transition temperature of an imperfect Bose gas in traps.An interacting model in quantum statistical mechanics is presented.With the model we study a Bose gas with attractive interaction trapped in an external potential.We obtain the result that the transition temperature of a trapped Bose gas will slightly shift upwards owing to the attractive interacting force.Successful application of the FIA to Bose systems is demonstrated.

  13. A biomimetic functionalization approach to integration of carbon nanoutbes into biological systems

    Science.gov (United States)

    Chen, Xing; Tam, Un Chong; Bertozzi, Carolyn; Zettl, Alex

    2006-03-01

    Due to their remarkable structural, electrical, and mechanical properties, carbon nanotubes (CNTs) have potential applications in biology ranging from imaging and tissue engineering. To realize these applications, however, new strategies for controlling the interaction between CNTs and biological systems such as proteins and cells are required. Here we describe a biomimetic approach to functionalize CNTs and therefore render them biocompatibility in order to facilitate their integration into biological systems. CNTs were coated with synthetic gycopolymers that mimic cell surface mucin gycoproteins. The functionalized CNTs were soluble in water, resisted non-specific protein binding and bound specifically to biomolecules. The coated CNTs could then be integrated onto mammalian cell surface by virtue of glycan-receptor interactions. Furthermore, the functionalized CNTs are non-toxic to cells. This strategy offers new opportunities for development of biosensor to probe biological processes. References: 1. X. Chen, G. S. Lee, A. Zettl, C. R. Bertozzi, Angewandte Chemie-International Edition 43, 6111 (2004). 2. X. Chen, U. C. Tam, J. L. Czlapanski, G. S. Lee, D. Rabuka, A. Zettl, C. R. Bertozzi, submitted.

  14. Fracture and fatigue analysis of functionally graded and homogeneous materials using singular integral equation approach

    Science.gov (United States)

    Zhao, Huaqing

    There are two major objectives of this thesis work. One is to study theoretically the fracture and fatigue behavior of both homogeneous and functionally graded materials, with or without crack bridging. The other is to further develop the singular integral equation approach in solving mixed boundary value problems. The newly developed functionally graded materials (FGMs) have attracted considerable research interests as candidate materials for structural applications ranging from aerospace to automobile to manufacturing. From the mechanics viewpoint, the unique feature of FGMs is that their resistance to deformation, fracture and damage varies spatially. In order to guide the microstructure selection and the design and performance assessment of components made of functionally graded materials, in this thesis work, a series of theoretical studies has been carried out on the mode I stress intensity factors and crack opening displacements for FGMs with different combinations of geometry and material under various loading conditions, including: (1) a functionally graded layer under uniform strain, far field pure bending and far field axial loading, (2) a functionally graded coating on an infinite substrate under uniform strain, and (3) a functionally graded coating on a finite substrate under uniform strain, far field pure bending and far field axial loading. In solving crack problems in homogeneous and non-homogeneous materials, a very powerful singular integral equation (SEE) method has been developed since 1960s by Erdogan and associates to solve mixed boundary value problems. However, some of the kernel functions developed earlier are incomplete and possibly erroneous. In this thesis work, mode I fracture problems in a homogeneous strip are reformulated and accurate singular Cauchy type kernels are derived. Very good convergence rates and consistency with standard data are achieved. Other kernel functions are subsequently developed for mode I fracture in

  15. Functional Integration

    Science.gov (United States)

    Cartier, Pierre; DeWitt-Morette, Cecile

    2010-06-01

    Acknowledgements; List symbols, conventions, and formulary; Part I. The Physical and Mathematical Environment: 1. The physical and mathematical environment; Part II. Quantum Mechanics: 2. First lesson: gaussian integrals; 3. Selected examples; 4. Semiclassical expansion: WKB; 5. Semiclassical expansion: beyond WKB; 6. Quantum dynamics: path integrals and operator formalism; Part III. Methods from Differential Geometry: 7. Symmetries; 8. Homotopy; 9. Grassmann analysis: basics; 10. Grassmann analysis: applications; 11. Volume elements, divergences, gradients; Part IV. Non-Gaussian Applications: 12. Poisson processes in physics; 13. A mathematical theory of Poisson processes; 14. First exit time: energy problems; Part V. Problems in Quantum Field Theory: 15. Renormalization 1: an introduction; 16. Renormalization 2: scaling; 17. Renormalization 3: combinatorics; 18. Volume elements in quantum field theory Bryce DeWitt; Part VI. Projects: 19. Projects; Appendix A. Forward and backward integrals: spaces of pointed paths; Appendix B. Product integrals; Appendix C. A compendium of gaussian integrals; Appendix D. Wick calculus Alexander Wurm; Appendix E. The Jacobi operator; Appendix F. Change of variables of integration; Appendix G. Analytic properties of covariances; Appendix H. Feynman's checkerboard; Bibliography; Index.

  16. An integrative approach to ortholog prediction for disease-focused and other functional studies

    Directory of Open Access Journals (Sweden)

    Perrimon Norbert

    2011-08-01

    Full Text Available Abstract Background Mapping of orthologous genes among species serves an important role in functional genomics by allowing researchers to develop hypotheses about gene function in one species based on what is known about the functions of orthologs in other species. Several tools for predicting orthologous gene relationships are available. However, these tools can give different results and identification of predicted orthologs is not always straightforward. Results We report a simple but effective tool, the Drosophila RNAi Screening Center Integrative Ortholog Prediction Tool (DIOPT; http://www.flyrnai.org/diopt, for rapid identification of orthologs. DIOPT integrates existing approaches, facilitating rapid identification of orthologs among human, mouse, zebrafish, C. elegans, Drosophila, and S. cerevisiae. As compared to individual tools, DIOPT shows increased sensitivity with only a modest decrease in specificity. Moreover, the flexibility built into the DIOPT graphical user interface allows researchers with different goals to appropriately 'cast a wide net' or limit results to highest confidence predictions. DIOPT also displays protein and domain alignments, including percent amino acid identity, for predicted ortholog pairs. This helps users identify the most appropriate matches among multiple possible orthologs. To facilitate using model organisms for functional analysis of human disease-associated genes, we used DIOPT to predict high-confidence orthologs of disease genes in Online Mendelian Inheritance in Man (OMIM and genes in genome-wide association study (GWAS data sets. The results are accessible through the DIOPT diseases and traits query tool (DIOPT-DIST; http://www.flyrnai.org/diopt-dist. Conclusions DIOPT and DIOPT-DIST are useful resources for researchers working with model organisms, especially those who are interested in exploiting model organisms such as Drosophila to study the functions of human disease genes.

  17. Effect of integrated approach of yoga therapy on autonomic functions in patients with type 2 diabetes.

    Science.gov (United States)

    Vinutha, H T; Raghavendra, B R; Manjunath, N K

    2015-01-01

    Integrated approach of yoga therapy (IAYT) had shown beneficial effects in the management of type 2 diabetes mellitus (DM). Autonomic dysfunction is one of the major complications of type 2 DM. Research studies have demonstrated that yoga can modulate autonomic functions. Hence, the current study was designed to assess the effect of IAYT on autonomic functions in type 2 diabetics. 15 patients of type 2 DM with ages ranging from 35 to 60 years were recruited for the study. They were diagnosed with type 2 diabetes from 1-year to 15 years. Assessments were made on day 1 (before yoga) and day 7 (after 1-week of yoga practice). Heart rate variability (HRV), blood pressure (BP) response to the isometric handgrip and heart rate response to deep breathing were assessed before and after 1-week of IAYT. There was a significant reduction in fasting plasma glucose from 154.67-130.27 mg/dL (Wilcoxon signed rank test, P = 0.029) following 1-week of IAYT. BP response to isometric hand grip improved significantly (Wilcoxon signed rank test, P = 0.01). There was no statistical significant change in HRV components and heart rate response to deep breathing test. However, there was a trend of increase in the low frequency power (41.07%), high frequency power (6.29%), total power (5.38%), and standard deviation of all NN intervals (SDNN) (6.29%). These findings suggest that, IAYT improved autonomic functions in type 2 diabetes patients.

  18. Effect of integrated approach of yoga therapy on autonomic functions in patients with type 2 diabetes

    Directory of Open Access Journals (Sweden)

    H T Vinutha

    2015-01-01

    Full Text Available Background and Objectives: Integrated approach of yoga therapy (IAYT had shown beneficial effects in the management of type 2 diabetes mellitus (DM. Autonomic dysfunction is one of the major complications of type 2 DM. Research studies have demonstrated that yoga can modulate autonomic functions. Hence, the current study was designed to assess the effect of IAYT on autonomic functions in type 2 diabetics. Materials and Methods: 15 patients of type 2 DM with ages ranging from 35 to 60 years were recruited for the study. They were diagnosed with type 2 diabetes from 1-year to 15 years. Assessments were made on day 1 (before yoga and day 7 (after 1-week of yoga practice. Heart rate variability (HRV, blood pressure (BP response to the isometric handgrip and heart rate response to deep breathing were assessed before and after 1-week of IAYT. Results: There was a significant reduction in fasting plasma glucose from 154.67-130.27 mg/dL (Wilcoxon signed rank test, P = 0.029 following 1-week of IAYT. BP response to isometric hand grip improved significantly (Wilcoxon signed rank test, P = 0.01. There was no statistical significant change in HRV components and heart rate response to deep breathing test. However, there was a trend of increase in the low frequency power (41.07%, high frequency power (6.29%, total power (5.38%, and standard deviation of all NN intervals (SDNN (6.29%. Conclusion: These findings suggest that, IAYT improved autonomic functions in type 2 diabetes patients.

  19. Block-pulse functions approach to numerical solution of Abel’s integral equation

    Directory of Open Access Journals (Sweden)

    Monireh Nosrati Sahlan

    2015-12-01

    Full Text Available This study aims to present a computational method for solving Abel’s integral equation of the second kind. The introduced method is based on the use of Block-pulse functions (BPFs via collocation method. Abel’s integral equations as singular Volterra integral equations are hard and heavy in computation, but because of the properties of BPFs, as is reported in examples, this method is more efficient and more accurate than some other methods for solving this class of integral equations. On the other hand, the benefit of this method is low cost of computing operations. The applied method transforms the singular integral equation into triangular linear algebraic system that can be solved easily. An error analysis is worked out and applications are demonstrated through illustrative examples.

  20. Integrating timescales with time-transfer functions: a practical approach for an INTIMATE database

    Science.gov (United States)

    Bronk Ramsey, Christopher; Albert, Paul; Blockley, Simon; Hardiman, Mark; Lane, Christine; Macleod, Alison; Matthews, Ian P.; Muscheler, Raimund; Palmer, Adrian; Staff, Richard A.

    2014-12-01

    The purpose of the INTIMATE project is to integrate palaeo-climate information from terrestrial, ice and marine records so that the timing of environmental response to climate forcing can be compared in both space and time. One of the key difficulties in doing this is the range of different methods of dating that can be used across different disciplines. For this reason, one of the main outputs of INTIMATE has been to use an event-stratigraphic approach which enables researchers to co-register synchronous events (such as the deposition of tephra from major volcanic eruptions) in different archives (Blockley et al., 2012). However, this only partly solves the problem, because it gives information only at particular short intervals where such information is present. Between these points the ability to compare different records is necessarily less precise chronologically. What is needed therefore is a way to quantify the uncertainties in the correlations between different records, even if they are dated by different methods, and make maximum use of the information available that links different records. This paper outlines the design of a database that is intended to provide integration of timescales and associated environmental proxy information. The database allows for the fact that all timescales have their own limitations, which should be quantified in terms of the uncertainties quoted. It also makes use of the fact that each timescale has strengths in terms of describing the data directly associated with it. For this reason the approach taken allows users to look at data on any timescale that can in some way be related to the data of interest, rather than specifying a specific timescale or timescales which should always be used. The information going into the database is primarily: proxy information (principally from sediments and ice cores) against depth, age depth models against reference chronologies (typically IntCal or ice core), and time-transfer functions

  1. The Integration of Quality Management Functions within a University: A Systems Approach

    Science.gov (United States)

    Brits, H. J.

    2011-01-01

    According to a recent study, institutions of higher learning in South Africa fail to a great extent to integrate the key management functions that are fundamental to effective quality management. This article argues that the effective promotion of quality of a university's core business depends to a large extent on the ability of an institution's…

  2. Identifying functional modules in protein-protein interaction networks: An integrated exact approach

    NARCIS (Netherlands)

    Dittrich, M.; Klau, G.W.; Rosenwald, A.; Dandekar, T.; et al, not CWI

    2008-01-01

    Motivation: With the exponential growth of expression and protein-protein interaction (PPI) data, the frontier of research in system biology shifts more and more to the integrated analysis of these large datasets. Of particular interest is the identification of functional modules in PPI networks, sh

  3. The Integration of Quality Management Functions within a University: A Systems Approach

    Science.gov (United States)

    Brits, H. J.

    2011-01-01

    According to a recent study, institutions of higher learning in South Africa fail to a great extent to integrate the key management functions that are fundamental to effective quality management. This article argues that the effective promotion of quality of a university's core business depends to a large extent on the ability of an institution's…

  4. A technological and physiological integrated approach for appetite control : from identification of novel biomarkers to development of new functional ingredients

    NARCIS (Netherlands)

    Mennella, I.

    2015-01-01

    A technological and physiological integrated approach for appetite control. From identification of novel biomarkers to development of new functional ingredients. Human dietary behaviour is driven by homeostatic, hedonic and environmental factors. Foods can influence

  5. Functional integration over geometries

    CERN Document Server

    Mottola, E

    1995-01-01

    The geometric construction of the functional integral over coset spaces {\\cal M}/{\\cal G} is reviewed. The inner product on the cotangent space of infinitesimal deformations of \\cal M defines an invariant distance and volume form, or functional integration measure on the full configuration space. Then, by a simple change of coordinates parameterizing the gauge fiber \\cal G, the functional measure on the coset space {\\cal M}/{\\cal G} is deduced. This change of integration variables leads to a Jacobian which is entirely equivalent to the Faddeev-Popov determinant of the more traditional gauge fixed approach in non-abelian gauge theory. If the general construction is applied to the case where \\cal G is the group of coordinate reparametrizations of spacetime, the continuum functional integral over geometries, {\\it i.e.} metrics modulo coordinate reparameterizations may be defined. The invariant functional integration measure is used to derive the trace anomaly and effective action for the conformal part of the me...

  6. The Functional Model Approach to the Consulting for Vertically - Integrated Construction Group

    Directory of Open Access Journals (Sweden)

    Pimenova Anna

    2016-01-01

    Full Text Available Managerial decision making in the framework of functional modeling of the consulting process have a direct effect on other business - processes of vertically - integrated group of construction companies. As a result, the experience of consulting companies tends to be used for the making managerial solutions. Consultancy is known as one of the most complicated types of buisiness process. It requires a huge and deep examines and researches of targeting area, therefore need to be provided with special methodology, included internal standards of the consulting companies. Correct methodological support, planning process and implementation of managerial solutions should be based on the survey of the direct and inverse connections and interdependence of all group’s business – processes. Functional - process modeling of the vertically - integrated construction group could be considered as an instrument of examination and analysis of the issue how the managerial solution impact on the business-process for the construction group functioning. The main result of the research is the formalized process-oriented model – prototype of the business - processes of vertically - integrated group of construction companies.

  7. The Neural Substrate and Functional Integration of Uncertainty in Decision Making: An Information Theory Approach

    Science.gov (United States)

    Goñi, Joaquín; Aznárez-Sanado, Maite; Arrondo, Gonzalo; Fernández-Seara, María; Loayza, Francis R.; Heukamp, Franz H.; Pastor, María A.

    2011-01-01

    Decision making can be regarded as the outcome of cognitive processes leading to the selection of a course of action among several alternatives. Borrowing a central measurement from information theory, Shannon entropy, we quantified the uncertainties produced by decisions of participants within an economic decision task under different configurations of reward probability and time. These descriptors were used to obtain blood oxygen level-dependent (BOLD) signal correlates of uncertainty and two clusters codifying the Shannon entropy of task configurations were identified: a large cluster including parts of the right middle cingulate cortex (MCC) and left and right pre-supplementary motor areas (pre-SMA) and a small cluster at the left anterior thalamus. Subsequent functional connectivity analyses using the psycho-physiological interactions model identified areas involved in the functional integration of uncertainty. Results indicate that clusters mostly located at frontal and temporal cortices experienced an increased connectivity with the right MCC and left and right pre-SMA as the uncertainty was higher. Furthermore, pre-SMA was also functionally connected to a rich set of areas, most of them associative areas located at occipital and parietal lobes. This study provides a map of the human brain segregation and integration (i.e., neural substrate and functional connectivity respectively) of the uncertainty associated to an economic decision making paradigm. PMID:21408065

  8. Fluidic Logic Used in a Systems Approach to Enable Integrated Single-cell Functional Analysis

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    Naveen Ramalingam

    2016-09-01

    Full Text Available The study of single cells has evolved over the past several years to include expression and genomic analysis of an increasing number of single cells. Several studies have demonstrated wide-spread variation and heterogeneity within cell populations of similar phenotype. While the characterization of these populations will likely set the foundation for our understanding of genomic- and expression-based diversity, it will not be able to link the functional differences of a single cell to its underlying genomic structure and activity. Currently, it is difficult to perturb single cells in a controlled environment, monitor and measure the response due to perturbation, and link these response measurements to downstream genomic and transcriptomic analysis. In order to address this challenge, we developed a platform to integrate and miniaturize many of the experimental steps required to study single-cell function. The heart of this platform is an elastomer-based Integrated Fluidic Circuit (IFC that uses fluidic logic to select and sequester specific single cells based on a phenotypic trait for downstream experimentation. Experiments with sequestered cells that have been performed include on-chip culture, exposure to a variety of stimulants, and post-exposure image-based response analysis, followed by preparation of the mRNA transcriptome for massively parallel sequencing analysis. The flexible system embodies experimental design and execution that enable routine functional studies of single cells.

  9. Biomechanical Approaches for Studying Integration of Tissue Structure and Function in Mammary Epithelia

    Science.gov (United States)

    Alcaraz, Jordi; Nelson, Celeste M.; Bissell, Mina J.

    2010-01-01

    The structure and function of each individual mammary epithelial cell (MEC) is largely controlled by a bidirectional interchange of chemical and mechanical signals with the microenvironment. Most of these signals are tissue-specific, since they arise from the three-dimensional (3D) tissue organization and are modulated during mammary gland development, maturation, pregnancy, lactation, and involution. Although the important role played by structural and mechanical signals in mammary cell and tissue function is being increasingly recognized, quantitative biomechanical approaches are still scarce. Here we review currently available biomechanical tools that allow quantitative examination of individual cells, groups of cells or full monolayers in two-dimensional cultures, and cells in 3D cultures. Current technological limitations and challenges are discussed, with special emphasis on their potential applications in MEC biology. We argue that the combination of biomechanical tools with current efforts in mathematical modeling and in cell and molecular biology applied to 3D cultures provides a powerful approach to unravel the complexity of tissue-specific structure-function relationships. PMID:15838605

  10. CARDINAL FUNCTIONS AND INTEGRAL FUNCTIONS

    OpenAIRE

    MIRCEA E. ŞELARIU; FLORENTIN SMARANDACHE; MARIAN NIŢU

    2015-01-01

    This paper presents the correspondences of the eccentric mathematics of cardinal and integral functions and centric mathematics, or ordinary mathematics. Centric functions will also be presented in the introductory section, because they are, although widely used in undulatory physics, little known.

  11. CARDINAL FUNCTIONS AND INTEGRAL FUNCTIONS

    OpenAIRE

    MIRCEA E. ŞELARIU; FLORENTIN SMARANDACHE; MARIAN NIŢU

    2015-01-01

    This paper presents the correspondences of the eccentric mathematics of cardinal and integral functions and centric mathematics, or ordinary mathematics. Centric functions will also be presented in the introductory section, because they are, although widely used in undulatory physics, little known.

  12. APPROACHES TO PUBLIC INTEGRITY

    Directory of Open Access Journals (Sweden)

    Simona-Roxana ULMAN

    2015-08-01

    Full Text Available Both concepts, integrity and public integrity, are always asked qualities in the social and economic environment, but they are never well defined. In this context, finding precise definitions and offering an ample explanation of the concepts are desired and useful for both economic theoretical and practical levels and become the aim of the present paper. Without a good understanding of a concept, no one is capable to attain it. In this context, it is impossible to ask for a public sector of integrity if both public actors and the citizens do not know what it really means. Therefore, the public actors first have to understand what integrity really supposes, and, then, to be capable to respect its principles. Taking into consideration the effects of public integrity or, on its opposite, of the divergence from it, especially represented by the phenomenon of corruption, on the economy at the macro, but also, on the micro level, public integrity in itself becomes a real economic problem that is aimed to be extensively analyzed through our interdisciplinary approach.

  13. Integrals of Bessel functions

    CERN Document Server

    Luke, Yudell L

    2014-01-01

    Integrals of Bessel Functions concerns definite and indefinite integrals, the evaluation of which is necessary to numerous applied problems. A massive compendium of useful information, this volume represents a resource for applied mathematicians in many areas of academia and industry as well as an excellent text for advanced undergraduates and graduate students of mathematics.Starting with an extensive introductory chapter on basic formulas, the treatment advances to indefinite integrals, examining them in terms of Lommel and Bessel functions. Subsequent chapters explore airy functions, incomp

  14. Exercising body and mind: an integrated approach to functional independence in hospitalized older people.

    Science.gov (United States)

    Mudge, Alison M; Giebel, Andrea J; Cutler, Alison J

    2008-04-01

    To evaluate the effect of a structured, multi-component, early rehabilitation program on functional status, delirium, and discharge outcomes of older acute medical inpatients. Prospective controlled trial with blinded outcome evaluation. Internal medicine service of a metropolitan tertiary teaching hospital in Brisbane, Australia. One hundred twenty-four consecutive inpatients aged 65 and older admitted from the emergency department to control or intervention medical ward. Exclusions included patients completely dependent before admission or admitted from a nursing home, patients too ill to participate or terminally ill, and patients with length of stay less than 72 hours. Early physiotherapy review with provision of an individualized graduated exercise program and activity diary, progressive encouragement of functional independence by nursing staff and other members of the multidisciplinary team, and cognitive stimulation sessions. Modified Barthel Index (MBI) at admission and discharge, timed up-and-go at admission and discharge, incidence of delirium and falls, measured activity, length of hospital stay, discharge destination, 30-day readmission rate. Intervention and control participants were well matched in terms of age, sex, diagnosis, and functional status. The intervention group had greater improvement in functional status than the control group, with a median MBI improvement of 8.5 versus 3.5 points (P=.03). In the intervention group, there was a reduction in delirium (19.4% vs 35.5%, P=.04) and a trend to reduced falls (4.8% vs 11.3%, P=.19). Length of stay, timed up-and-go, discharge destination, and readmissions did not differ between the groups. This intervention was effective in improving function in a vulnerable patient group.

  15. The quality of volunteers' motives: Integrating the functional approach and self-determination theory.

    Science.gov (United States)

    Güntert, Stefan Tomas; Strubel, Isabel Theresia; Kals, Elisabeth; Wehner, Theo

    2016-01-01

    Volunteers' motives have been differentially linked to various aspects of successful volunteering. Using self-determination theory, we propose that volunteer functions are systematically related to the experience of self-determined versus controlled motivation. This "quality of motivation," in turn, explains why motives are differentially associated with satisfaction. We conducted two studies: Study 1 (N1 = 824) addressed motives, quality of motivation, and satisfaction; Study 2 (N2 = 323) additionally examined function-specific benefits and the extent to which they match volunteers' motives. Overall, our hypotheses were supported: values, understanding, and social justice motives were positively associated with relatively self-determined motivation (RSM), whereas career, social, protective, and enhancement motives showed negative correlations. The relationships between motives and satisfaction were partially mediated by RSM. Concerning benefits, Study 2 corroborated these findings for values, protective, enhancement, and social justice. This research introduces a new perspective on the quality of volunteers' motives-with theoretical and practical implications.

  16. Functional morphology and integration of corvid skulls – a 3D geometric morphometric approach

    Directory of Open Access Journals (Sweden)

    Gunz Philipp

    2009-01-01

    Full Text Available Abstract Background Sympatric corvid species have evolved differences in nesting, habitat choice, diet and foraging. Differences in the frequency with which corvid species use their repertoire of feeding techniques is expected to covary with bill-shape and with the frontal binocular field. Species that frequently probe are expected to have a relatively longer bill and more sidewise oriented orbits in contrast to species that frequently peck. We tested this prediction by analyzing computed tomography scans of skulls of six corvid species by means of three-dimensional geometric morphometrics. We (1 explored patterns of major variation using principal component analysis, (2 compared within and between species relationships of size and shape and (3 quantitatively compared patterns of morphological integration between bill and cranium by means of partial least squares (singular warp analysis. Results Major shape variation occurs at the bill, in the orientation of orbits, in the position of the foramen magnum and in the angle between bill and cranium. The first principal component correlated positively with centroid-size, but within-species allometric relationships differed markedly. Major covariation between the bill and cranium lies in the difference in orbit orientation relative to bill-length and in the angle between bill and cranium. Conclusion Corvid species show pronounced differences in skull shape, which covary with foraging mode. Increasing bill-length, bill-curvature and sidewise orientation of the eyes is associated with an increase in the observed frequency in probing (vice versa in pecking. Hence, the frequency of probing, bill-length, bill-curvature and sidewise orientation of the eyes is progressively increased from jackdaw, to Eurasian jay, to black-billed magpie, to hooded crow, to rook and to common raven (when feeding on carcasses is considered as probing. Our results on the morphological integration suggest that most of the

  17. Polydopamine meets solid-state nanopores: a bioinspired integrative surface chemistry approach to tailor the functional properties of nanofluidic diodes.

    Science.gov (United States)

    Pérez-Mitta, Gonzalo; Tuninetti, Jimena S; Knoll, Wolfgang; Trautmann, Christina; Toimil-Molares, María Eugenia; Azzaroni, Omar

    2015-05-13

    The ability to modulate the surface chemical characteristics of solid-state nanopores is of great interest as it provides the means to control the macroscopic response of nanofluidic devices. For instance, controlling surface charge and polarity of the pore walls is one of the most important applications of surface modification that is very relevant to attain accurate control over the transport of ions through the nanofluidic architecture. In this work, we describe a new integrative chemical approach to fabricate nanofluidic diodes based on the self-polymerization of dopamine (PDOPA) on asymmetric track-etched nanopores. Our results demonstrate that PDOPA coating is not only a simple and effective method to modify the inner surface of polymer nanopores fully compatible with the fabrication of nanofluidic devices but also a versatile platform for further integration of more complex molecules through different covalent chemistries and self-assembly processes. We adjusted the chemical modification strategy to obtain various configurations of the pore surface: (i) PDOPA layer was used as primer, precursor, or even responsive functional coating; (ii) PDOPA layer was used as a platform for anchoring chemical functions via the Michael addition reaction; and (iii) PDOPA was used as a reactive layer inducing the metallization of the pore walls through the in situ reduction of metallic precursors present in solution. We believe that the transversal concept of integrative surface chemistry offered by polydopamine in combination with the remarkable physical characteristics of asymmetric nanopores constitutes a new framework to design multifunctional nanofluidic devices employing soft chemistry-based nanofunctionalization techniques.

  18. An Algebraic Approach to a Calculus of Functional Differences: Fixed Differences and Integrals,

    Science.gov (United States)

    1987-09-01

    34 bxo " (31) That is, the functions gkb don’t care if an element of S can be generated in two or more ways. Lemma 17-1: Suppose b: D- T. f: S -- T. g: T...and or gbx. for x h "z (35) To show or is single valued, assume hmI(, h’z 0 ’. By Eq. 35. ox 9" bxo , or g bo" But the gkb ignore the generation of 5. so...g -b g" bxo ’. Hence. o is single valued. Next we prove that ohbg is a solution proxided the gk b ignore generation. -21- If

  19. Structures and hydrologic function of soil landscapes with kettle holes using an integrated hydropedological approach

    Science.gov (United States)

    Gerke, Horst H.; Koszinski, Sylvia; Kalettka, Thomas; Sommer, Michael

    2010-10-01

    SummaryThe hummocky post-glacial soil landscapes with kettle holes as internal drainage systems are characterized by ponds that trap lateral fluxes in topographic depressions. A quantitative description is mostly limited by the unknown complexity of hydraulically relevant soil and sediment structures. This paper is focussing on a structure-based approach to identify relevant field-scale flow and transport processes. Illustrative examples demonstrate extreme variations in water table fluctuation for adjoining kettle holes. Explanations require a pedohydrologic concept of the arable soil landscape. Identification of structures is based on geophysical methods and soil hydraulic measurements. Electrical resistivity imaging yields 0.5 m-scale spatial structures that correspond with soil texture distributions. Electromagnetic induction provides larger-scale field maps that reflect major soil and sediment features. Results of both methods correspond within the limits of the different spatial resolutions. With geophysical exploration methods, colluvial areas with textural differences between upper and deeper soil layers, coarse-textured sediment lenses, and stony colluvial regions around kettle holes are identified as potentially relevant flow structures. The colluvial fringe around the pond seems to be a sensitive area with important lateral exchange fluxes. Tensiometer measurements perpendicular to this boundary indicate hydraulic gradients directed from the pond towards the partially saturated soil. The localized infiltration of trapped water in kettle holes can control large fractions of ground water recharge and may have implications for the fate of agricultural chemicals in post-glacial landscapes. While surface and subsurface hydraulic structures may be inferred using minimal-invasive techniques, better understanding of processes and properties governing lateral exchange fluxes between pond and surrounding soil are required.

  20. Function integrated track system

    OpenAIRE

    Hohnecker, Eberhard

    2010-01-01

    The paper discusses a function integrated track system that focuses on the reduction of acoustic emissions from railway lines. It is shown that the combination of an embedded rail system (ERS), a sound absorbing track surface, and an integrated mini sound barrier has significant acoustic advantages compared to a standard ballast superstructure. The acoustic advantages of an embedded rail system are particularly pronounced in the case of railway bridges. Finally, it is shown that a...

  1. Pair Correlation Function Integrals

    DEFF Research Database (Denmark)

    Wedberg, Nils Hejle Rasmus Ingemar; O'Connell, John P.; Peters, Günther H.J.;

    2011-01-01

    numerical tests complementing previous results. Pure molecular fluids are here studied in the isothermal-isobaric ensemble with isothermal compressibilities evaluated from the total correlation function integrals and compared with values derived from volume fluctuations. For systems where the radial......We describe a method for extending radial distribution functions obtained from molecular simulations of pure and mixed molecular fluids to arbitrary distances. The method allows total correlation function integrals to be reliably calculated from simulations of relatively small systems. The long......, and J. Abildskov, Mol. Simul. 36, 1243 (2010); Fluid Phase Equilib. 302, 32 (2011)], but describe here its theoretical basis more thoroughly and derive long-distance approximations for the direct correlation functions. We describe the numerical implementation of the method in detail, and report...

  2. An Integrated model for Product Quality Development—A case study on Quality functions deployment and AHP based approach

    Science.gov (United States)

    Maitra, Subrata; Banerjee, Debamalya

    2010-10-01

    Present article is based on application of the product quality and improvement of design related with the nature of failure of machineries and plant operational problems of an industrial blower fan Company. The project aims at developing the product on the basis of standardized production parameters for selling its products in the market. Special attention is also being paid to the blower fans which have been ordered directly by the customer on the basis of installed capacity of air to be provided by the fan. Application of quality function deployment is primarily a customer oriented approach. Proposed model of QFD integrated with AHP to select and rank the decision criterions on the commercial and technical factors and the measurement of the decision parameters for selection of best product in the compettitive environment. The present AHP-QFD model justifies the selection of a blower fan with the help of the group of experts' opinion by pairwise comparison of the customer's and ergonomy based technical design requirements. The steps invoved in implementation of the QFD—AHP and selection of weighted criterion may be helpful for all similar purpose industries maintaining cost and utility for competitive product.

  3. Beyond biological monitoring: an integrated approach

    NARCIS (Netherlands)

    Verdonschot, P.F.M.

    2006-01-01

    Concluding discussion ‘Beyond Biological Monitoring: An Integrated Approach’ of the section New tools and strategies for river ecology evaluation – presents decision making on what constitutes a significant environmental change; predictive modelling approaches; evaluating fluvial functioning (FFI),

  4. Integrating function and mechanism.

    Science.gov (United States)

    McNamara, John M; Houston, Alasdair I

    2009-12-01

    Behavioural ecology often makes the assumption that animals can respond flexibly by adopting the optimal behaviour for each circumstance. However, as ethologists have long known, behaviour is determined by mechanisms that are not optimal in every circumstance. As we discuss here, we believe that it is necessary to integrate these separate traditions by considering the evolution of mechanisms, an approach referred to as 'Evo-mecho'. This integration is timely because there is a growing awareness of the importance of environmental complexity in shaping behaviour; there are established and effective computational procedures for simulating evolution and there is rapidly increasing knowledge of the neuronal basis of decision-making. Although behavioural ecologists have built complex models of optimal behaviour in simple environments, we argue that they need to focus on simple mechanisms that perform well in complex environments.

  5. Agricultural drainage: Towards an integrated approach

    NARCIS (Netherlands)

    Abdeldayem, S.; Hoevenaars, J.; Mollinga, P.P.; Scheuman, W.; Slootweg, R.; Steenbergen, van F.

    2005-01-01

    Drainage needs to reclaim its rightful position as an indispensable element in the integrated management of land and water. An integrated approach to drainage can be developed by means of systematic mapping of the functions of natural resources systems (goods and services) and the values attributed

  6. ABOUT THE INTEGRATED FORMATIONS AND METHODOLOGICAL APPROACHES TO THE ASSESSMENT OF THE EFFICIENCY OF THEIR FUNCTIONING IN AGRO-INDUSTRIAL COMPLEX

    Directory of Open Access Journals (Sweden)

    Lalayan G. G.

    2015-06-01

    Full Text Available The main directions and tendencies of development of the Russian economy are considered in the article. The strategic role of agro-industrial complex in providing food and economic security of the country is noted. The basic provisions of Strategy of social and economic development of agro-industrial complex of the Russian Federation till 2020 are analyzed. It is established that further development of cooperation and integration belongs to number of the priority directions laid down in the Strategy. The main types of the integrated structures in agro-industrial complex are considered. The most perfect organizational forms of the integrated formations in the system of agribusiness are allocated: agroholding, agrocorporation, financial and agro-industrial group, cluster. It is noticed that in the Russian agro-industrial sector the greatest distribution was gained by the vertically integrated structures of holding type. The attention is focused on the aspects of formation and functioning of clusters as an innovative form of integration. The relevance and necessity of an assessment of efficiency of the creation and functioning of the integrated structures is emphasized. The main methodological approaches to an assessment of the efficiency of integration in agro-industrial complex are considered on the basis of the analysis of domestic and foreign references. The lack of a unified approach to the problem under consideration is revealed. It is established that method of "cost-effectiveness" is the most widespread among domestic economists. The expediency of application of synergistic approach for determination of efficiency of integration is caused. The authors emphasized the need for a comprehensive assessment of efficiency of activity of agro-industrial units on the basis of the main provisions of the existing approaches

  7. Study of Sommerfeld and Phase-Integral Approaches for Green’s Functions for PEC-terminated Inhomogeneous Media

    Science.gov (United States)

    2010-01-08

    and A. S. Fokas, Complex Variables: Introduction and Applications. NY, USA: Cam- ridge University Press, 1997. 47. K. A. Michalski and J. R. Mosig...G. Alexopoulos, “Real Axis Integration of Sommerfeld Inetgrals,” Jour. Math. Phys., vol. 24, no. 3, pp. 527-533, March 1983. 57. K. A. Michalski ...Methods for Electromagnetic and Elastic Waves. USA: Morgan & Claypool, 2009. A2. K. A. Michalski and J. R. Mosig, “Multilayered Media Green’s Functions

  8. Functionally informed cortex based alignment: an integrated approach for whole-cortex macro-anatomical and ROI-based functional alignment.

    Science.gov (United States)

    Frost, Martin A; Goebel, Rainer

    2013-12-01

    Due to anatomical variability across subjects many brain mapping experiments have analysis focused on a few particular regions of interest so as to circumvent the problem of sub-optimal statistics resulting from the lack of anatomical correspondence across subjects. Since the topographic distribution of experimental effects across the cortex is also often of interest, two separate analyses are often conducted, one on the regions of interest alone, as well as a separate 'whole brain' analysis with sub-optimal spatial correspondence across brains. In this paper we present a new group alignment procedure which incorporates, from each subject, both macro-anatomical (curvature) information and functional information from standard localizer experiments. After specifying appropriate parameters to weight anatomical and functional alignment forces, we were able to create a group cortical reconstruction which was well aligned in terms of both anatomical and functional areas. We observed an increase in the overlap of functional areas as well as an improvement in group statistics following this integrated alignment procedure. We propose that, using this alignment scheme, two separate analyses may not be necessary as both analyses can be integrated into a single procedure. After an integrated structural and functional alignment one is able to carry out a whole brain analysis with improved statistical sensitivity due to the reduction in spatial variation in the location of functional regions of interest which fCBA accomplishes. Furthermore, regions in the vicinity of localised and aligned regions-of-interest will also benefit from the integrated alignment.

  9. Integrated Test Approach

    Science.gov (United States)

    Cotton, Will; Liechty, John

    2015-01-01

    This paper describes a testing methodology undertaken on the Facilities Development and Operations Contract (FDOC) by Lockheed Martin. The methodology was defined with the intent of reducing project schedule time to enable NASA's Johnson Space Center (JSC) to be able to deliver the Mission Control Center (MCC) 21 project as quickly as possible. 21 represents the 21st century where NASA JSC is updating its control center with new technology and operational concepts in order to support NASA customers wanting to use control center assets to support space vehicle operations. In collaboration with the NASA customer, a new test concept was conceived early during MCC21 project planning with the goal of reducing project delivery time. One enabler that could help reduce delivery time was testing. Within the project, testing was performed by two entities, software development responsible for subsystem testing and system test responsible for system integration testing. The MCC21 project took a deliberate review of testing to determine how it could be performed differently to realize an overall reduction in test time to support the goal of a more rapid project delivery.

  10. Integrated approach to prevent functional decline in hospitalized elderly: the Prevention and Reactivation Care Program (PReCaP

    Directory of Open Access Journals (Sweden)

    de Vos Annemarie JBM

    2012-03-01

    Full Text Available Abstract Background Hospital related functional decline in older patients is an underestimated problem. Thirty-five procent of 70-year old patients experience functional decline during hospital admission in comparison with pre-illness baseline. This percentage increases considerably with age. Methods/design To address this issue, the Vlietland Ziekenhuis in The Netherlands has implemented an innovative program (PReCaP, aimed at reducing hospital related functional decline among elderly patients by offering interventions that are multidisciplinary, integrated and goal-oriented at the physical, social, and psychological domains of functional decline. Discussion This paper presents a detailed description of the intervention, which incorporates five distinctive elements: (1 Early identification of elderly patients with a high risk of functional decline, and if necessary followed by the start of the reactivation treatment within 48 h after hospital admission; (2 Intensive follow-up treatment for a selected patient group at the Prevention and Reactivation Centre (PRC; (3 Availability of multidisciplinary geriatric expertise; (4 Provision of support and consultation of relevant professionals to informal caregivers; (5 Intensive follow-up throughout the entire chain of care by a casemanager with geriatric expertise. Outcome and process evaluations are ongoing and results will be published in a series of future papers. Trial registration The Netherlands National Trial Register: NTR2317

  11. Mechatronics an integrated approach

    CERN Document Server

    de Silva, Clarence W

    2004-01-01

    Table of MECHATRONIC ENGINEERINGMechatronic SystemsStudy of MechatronicsReferences and Further ReadingDYNAMIC MODELS AND ANALOGIESTerminologyAnalogiesState-Space Representation Model Linearization Linear GraphsState Models From Linear GraphsElectrical SystemsFluid SystemsThermal SystemsBond GraphsTransfer-Function ModelsFrequency Domain ModelsResponse Analysis And SimulationMECHANICAL COMPONENTS AND ROBOTIC MANIPULATORSMechanical ComponentsTransmission ComponentsRobotic ManipulatorsRobotic GrippersCOMPONENT INTERCONNECTION AND SIGNAL CONDITIONINGComponent InterconnectionImpedance Characteristi

  12. Thyroiditis: an integrated approach.

    Science.gov (United States)

    Sweeney, Lori B; Stewart, Christopher; Gaitonde, David Y

    2014-09-15

    Thyroiditis is a general term that encompasses several clinical disorders characterized by inflammation of the thyroid gland. The most common is Hashimoto thyroiditis; patients typically present with a nontender goiter, hypothyroidism, and an elevated thyroid peroxidase antibody level. Treatment with levothyroxine ameliorates the hypothyroidism and may reduce goiter size. Postpartum thyroiditis is transient or persistent thyroid dysfunction that occurs within one year of childbirth, miscarriage, or medical abortion. Release of preformed thyroid hormone into the bloodstream may result in hyperthyroidism. This may be followed by transient or permanent hypothyroidism as a result of depletion of thyroid hormone stores and destruction of thyroid hormone-producing cells. Patients should be monitored for changes in thyroid function. Beta blockers can treat symptoms in the initial hyperthyroid phase; in the subsequent hypothyroid phase, levothyroxine should be considered in women with a serum thyroid-stimulating hormone level greater than 10 mIU per L, or in women with a thyroid-stimulating hormone level of 4 to 10 mIU per L who are symptomatic or desire fertility. Subacute thyroiditis is a transient thyrotoxic state characterized by anterior neck pain, suppressed thyroid-stimulating hormone, and low radioactive iodine uptake on thyroid scanning. Many cases of subacute thyroiditis follow an upper respiratory viral illness, which is thought to trigger an inflammatory destruction of thyroid follicles. In most cases, the thyroid gland spontaneously resumes normal thyroid hormone production after several months. Treatment with high-dose acetylsalicylic acid or nonsteroidal anti-inflammatory drugs is directed toward relief of thyroid pain.

  13. Integrated Approach to Managing Sustainability

    OpenAIRE

    László Berényi

    2013-01-01

    Achieving a higher level of sustainable development needs both individual and corporate efforts. An effective solution needs an integrated approach that allows the consideration of environmental and social values in addition to the economic interest. Additional management tools may be useful but sustaining them needs often untenable efforts from the organisations.This paper draws up a framework for how to integrate the values of sustainable development into the corporate activities by using c...

  14. Dressed coordinates: The path-integral approach

    Science.gov (United States)

    Casana, R.; Flores-Hidalgo, G.; Pimentel, B. M.

    2007-02-01

    The recently introduced dressed coordinates are studied in the path-integral approach. These coordinates are defined in the context of a harmonic oscillator linearly coupled to massless scalar field and it is shown that in this model the dressed coordinates appear as a coordinate transformation preserving the path-integral functional measure. The analysis also generalizes the sum rules established in a previous work.

  15. Indecisiveness: A Dynamic, Integrative Approach.

    Science.gov (United States)

    Johnson, Douglas Paul

    1990-01-01

    Responds to case of Sondra presented in Career Development Quarterly (September 1990). Suggests that her inability to decide on a career may be rooted in long-term personality style, poor ego strength, noisome family dynamics, and/or developmental delay. Recommends an integrative approach incorporating both personal and career counseling. (PVV)

  16. Multiaxial diagnosis: An integral approach

    OpenAIRE

    Adalberto Campo Arias

    2003-01-01

    All patients must be diagnosed with an integral, multiaxial or bio-psycho-social model. This approach makes possible understanding biological,personality, social, and cultural factor or background of ill people. Multiaxial perspective gives diagnosis more accurate and reliable. Moreover, it makes clinical practice more warm and humane.

  17. The integrative approach to psychiatry.

    Science.gov (United States)

    Lipowski, Z J

    1990-12-01

    From the early days of psychiatry as a distinct field of knowledge and clinical practice two competing approaches to the etiology and treatment of mental disorders have vied for dominance: the somatic and the psychic ("moral"). We are witnessing the same struggle today. To speak metaphorically, we can opt for either brainless or mindless psychiatry, as Szasz proposed. He failed to consider a third option, however, one that may be called an integrative approach. The latter is neither mindless nor brainless but rather encompasses both the mind and the brain in its theoretical and practical consideration. I will formulate the integrative approach in this paper and argue that it has a distinct advantage for both the study and treatment of mental disorders.

  18. Integrated Functionality: Nanosensors

    Science.gov (United States)

    Devreese, Jozef T.

    2008-03-01

    Integrated nanosensors are nanostructured systems in which several sensors of different types have been integrated on a single platform including those sensitive to optical, magnetic, chemical, or biological stimuli [1,2]. Nanoparticle-based detector systems rely on the development of nanoparticles as sensing species. I discuss state-of-the-art nanosensors which are based on various advanced materials: nanoshells and nanorice, gold nanoparticles with attached fluorescent dyes, nanopores, carbon nanotubes, neuroelectronic hybrid systems, semiconductor nanocrystals and quantum-dot quantum wells (QDQW's). Phonon-assisted optical processes in semiconductor nanocrystals and QDQW's are highly sensitive to their shape and geometry i. a. due to the non-adiabaticity of the exciton-phonon systems. This sensitivity opens new perspectives for applications of quantum dots in optical sensing. For example, the simultaneous consideration of the tetrahedral shape of a CdS/HgS/CdS QDQW, interface optical phonons, and non-adiabatic phonon-assisted transitions allows for control of the photoluminescence of a QDQW [3]. Quantum-dot-based systems are also considered as examples of communication with nanodevices, which is a prerequisite of their integration. Nanosensors allow for building a new class of integrated devices, which provide the elemental base for ``intelligent sensors'' capable of data processing, storage and analysis. The development of integrated nanosensors could have many applications in several fields such as process monitoring, robotics, environmental, medical, consumer, homeland security [1] I. K. Schuller, http://nanosensors.ucsd.edu/Introduction.htm. [2] J. T. Devreese and Y. Bruynseraede, Integrated Nanosensors. McGraw-Hill 2008 Yearbook of Science & Technology, McGraw-Hill, 2008. [3] V. A. Fonoberov, E. P. Pokatilov, V. M. Fomin, and J. T. Devreese, Phys. Rev. Lett. 92, 127402 (2004).

  19. The importance of the natural and social resources in the function of the integrational and ambiental approach within the school function innovation

    Directory of Open Access Journals (Sweden)

    Anđelković Slađana

    2011-01-01

    Full Text Available In work, different possibilities are considered, which are offered by natural and social resources with the goal to change and modernize the teaching outside of the classroom in different environments. Modern teaching is based on the holistic, integrated approach in which the knowledge is viewed as a complete system in a constant process of transformation. Thus, the importance of the environment is asserted, the importance of the ambient in which the teaching process is being conducted. Authentic environment (natural and social resources in which the teaching is realized, outside of the classroom, creates possibilities for learning through active working methods, independent research, exploration and noticing the relationships and connections. Teaching in the authentic environment offers a series of advantages for both the students and teacher-partners in the process of constructing a knowledge system. Using the resources and modern complex integration approach within the existing educational practice can significantly influence the modernization and innovation of the educational process, and can make the school, as a basic educational institution, a more suitable and more attractive for the generations to come.

  20. Adult neurogenesis: integrating theories and separating functions

    OpenAIRE

    2010-01-01

    The continuous incorporation of new neurons in the dentate gyrus of the adult hippocampus raises exciting questions about memory and learning, and has inspired new computational models to understand the function of adult neurogenesis. These theoretical approaches suggest distinct roles for new neurons as they slowly integrate into the existing dentate gyrus network: immature adult-born neurons appear to function as pattern integrators of temporally adjacent events, thereby enhancing pattern s...

  1. Integral, measure and derivative a unified approach

    CERN Document Server

    Shilov, G E

    2012-01-01

    This graduate-level textbook and monograph defines the functions of a real variable through consistent use of the Daniell scheme, offering a rare and useful alternative to customary approaches. The treatment can be understood by any reader with a solid background in advanced calculus, and it features many problems with hints and answers. ""The exposition is fresh and sophisticated,"" declared Sci-Tech Book News, ""and will engage the interest of accomplished mathematicians."" Part one is devoted to the integral, moving from the Reimann integral and step functions to a general theory, and obta

  2. Cloning and functional characterization of the ovine Hormone Sensitive Lipase (HSL) full-length cDNAs: an integrated approach.

    Science.gov (United States)

    Lampidonis, Antonis D; Argyrokastritis, Alexandros; Stravopodis, Dimitrios J; Voutsinas, Gerassimos E; Ntouroupi, Triantafyllia G; Margaritis, Lukas H; Bizelis, Iosif; Rogdakis, Emmanuel

    2008-06-15

    Hormone Sensitive Lipase (HSL) is a highly regulated enzyme that mediates lipolysis in adipocytes. HSL enzymatic activity is increased by adrenergic agonists, such as catecholamines and glucagons, which induce cyclic AMP (cAMP) intracellular production, subsequently followed by the activation of Protein Kinase A (PKA) and its downstream signalling cascade reactions. Since HSL constitutes the key enzyme in the regulation of lipid stores and the only enzyme being subjected to hormonal regulation [in terms of the recently identified Adipose Triglyceride Lipase (ATGL)], the ovine Hormone Sensitive Lipase (ovHSL) full-length cDNA clones were isolated, using a Polymerase Chain Reaction-based (PCR) strategy. The two isolated isoforms ovHSL-A and ovHSL-B contain two highly homologous Open Reading Frame (ORF) regions of 2.089 Kb and 2.086 Kb, respectively, the latter having been missed the 688th triplet coding for glutamine (DeltaQ(688)). The putative 695 and 694 amino acid respective sequences bear strong homologies with other HSL protein family members. Southern blotting analysis revealed that HSL is represented as a single copy gene in the ovine genome, while Reverse Transcription-PCR (RT-PCR) approaches unambiguously dictated its variable transcriptional expression profile in the different tissues examined. Interestingly, as undoubtedly corroborated by both RT-PCR and Western blotting analysis, ovHSL gene expression is notably enhanced in the adipose tissue during the fasting period, when lipolysis is highly increased in ruminant species. Based on the crystal structure of an Archaeoglobus fulgidus enzyme, a three-dimensional (3D) molecular model of the ovHSL putative catalytic domain was constructed, thus providing an inchoative insight into understanding the enzymatic activity and functional regulation mechanisms of the ruminant HSL gene product(s).

  3. On Local Integrated Cosine Functions

    Institute of Scientific and Technical Information of China (English)

    SHI Jin-e; ZHENG Wei-xing

    2001-01-01

    Suppose X is a Banach space, and A is a closed operator. We give some equivalent conditions between A generating a local integrated cosine functions and the existence of solutions of abstract Cauchy problems.

  4. A Functional Approach to Integrated Assessment of Teacher Support and Student Discourse Development in an Elementary Chinese Program

    Science.gov (United States)

    Huang, Jingzi; Mohan, Bernard

    2009-01-01

    How can foreign language education integrate the learning of language with learning of content, and culture on a systematic basis, when assessment typically focuses on language in isolation from meaning? Examining developmental data gathered over a three-year period from elementary students in a Chinese program in North America, we explore the…

  5. Integrating cross-frequency and within band functional networks in resting-state MEG: A multi-layer network approach.

    Science.gov (United States)

    Tewarie, Prejaas; Hillebrand, Arjan; van Dijk, Bob W; Stam, Cornelis J; O'Neill, George C; Van Mieghem, Piet; Meier, Jil M; Woolrich, Mark W; Morris, Peter G; Brookes, Matthew J

    2016-11-15

    Neuronal oscillations exist across a broad frequency spectrum, and are thought to provide a mechanism of interaction between spatially separated brain regions. Since ongoing mental activity necessitates the simultaneous formation of multiple networks, it seems likely that the brain employs interactions within multiple frequency bands, as well as cross-frequency coupling, to support such networks. Here, we propose a multi-layer network framework that elucidates this pan-spectral picture of network interactions. Our network consists of multiple layers (frequency-band specific networks) that influence each other via inter-layer (cross-frequency) coupling. Applying this model to MEG resting-state data and using envelope correlations as connectivity metric, we demonstrate strong dependency between within layer structure and inter-layer coupling, indicating that networks obtained in different frequency bands do not act as independent entities. More specifically, our results suggest that frequency band specific networks are characterised by a common structure seen across all layers, superimposed by layer specific connectivity, and inter-layer coupling is most strongly associated with this common mode. Finally, using a biophysical model, we demonstrate that there are two regimes of multi-layer network behaviour; one in which different layers are independent and a second in which they operate highly dependent. Results suggest that the healthy human brain operates at the transition point between these regimes, allowing for integration and segregation between layers. Overall, our observations show that a complete picture of global brain network connectivity requires integration of connectivity patterns across the full frequency spectrum.

  6. Extending the functional cerebral systems theory of emotion to the vestibular modality: a systematic and integrative approach.

    Science.gov (United States)

    Carmona, Joseph E; Holland, Alissa K; Harrison, David W

    2009-03-01

    Throughout history, vestibular and emotional dysregulation have often manifested together in clinical settings, with little consideration that they may have a common basis. Regarding vestibular mechanisms, the role of brainstem and cerebellar structures has been emphasized in the neurological literature, whereas emotion processing in the cerebral hemispheres has been the focus in psychology. A conceptual model is proposed that links research in the 2 disparate fields by means of a functional cerebral systems framework. The claim is that frontal regions exert regulatory control over posterior systems for sensation and autonomic functions in a dense, interconnected network. Impairment at levels within the system is expected to influence vestibular and cognitive processes depending on the extent of frontal regulatory capacity. M. Kinsbourne's (1980) shared cerebral space model specifies the conditions under which dysfunction of the vestibular modality will influence higher cognitive levels. A position on laterality and associative relations within the right hemisphere is proposed to explain links among dizziness, nausea, and negative emotion. (c) 2009 APA, all rights reserved.

  7. Integrated approaches to perceptual learning.

    Science.gov (United States)

    Jacobs, Robert A

    2010-04-01

    New technologies and new ways of thinking have recently led to rapid expansions in the study of perceptual learning. We describe three themes shared by many of the nine articles included in this topic on Integrated Approaches to Perceptual Learning. First, perceptual learning cannot be studied on its own because it is closely linked to other aspects of cognition, such as attention, working memory, decision making, and conceptual knowledge. Second, perceptual learning is sensitive to both the stimulus properties of the environment in which an observer exists and to the properties of the tasks that the observer needs to perform. Moreover, the environmental and task properties can be characterized through their statistical regularities. Finally, the study of perceptual learning has important implications for society, including implications for science education and medical rehabilitation. Contributed articles relevant to each theme are summarized.

  8. A unified approach to infinite-dimensional integration

    Science.gov (United States)

    Albeverio, S.; Mazzucchi, S.

    2016-04-01

    An approach to infinite-dimensional integration which unifies the case of oscillatory integrals and the case of probabilistic type integrals is presented. It provides a truly infinite-dimensional construction of integrals as linear functionals, as much as possible independent of the underlying topological and measure theoretical structure. Various applications are given, including, next to Feynman path integrals, Schrödinger and diffusion equations, as well as higher order hyperbolic and parabolic equations.

  9. Optical Properties of Gold Nanoclusters Functionalized with a Small Organic Compound: Modeling by an Integrated Quantum-Classical Approach.

    Science.gov (United States)

    Li, Xin; Carravetta, Vincenzo; Li, Cui; Monti, Susanna; Rinkevicius, Zilvinas; Ågren, Hans

    2016-07-12

    Motivated by the growing importance of organometallic nanostructured materials and nanoparticles as microscopic devices for diagnostic and sensing applications, and by the recent considerable development in the simulation of such materials, we here choose a prototype system - para-nitroaniline (pNA) on gold nanoparticles - to demonstrate effective strategies for designing metal nanoparticles with organic conjugates from fundamental principles. We investigated the motion, adsorption mode, and physical chemistry properties of gold-pNA particles, increasing in size, through classical molecular dynamics (MD) simulations in connection with quantum chemistry (QC) calculations. We apply the quantum mechanics-capacitance molecular mechanics method [Z. Rinkevicius et al. J. Chem. Theory Comput. 2014, 10, 989] for calculations of the properties of the conjugate nanoparticles, where time dependent density functional theory is used for the QM part and a capacitance-polarizability parametrization of the MM part, where induced dipoles and charges by metallic charge transfer are considered. Dispersion and short-range repulsion forces are included as well. The scheme is applied to one- and two-photon absorption of gold-pNA clusters increasing in size toward the nanometer scale. Charge imaging of the surface introduces red-shifts both because of altered excitation energy dependence and variation of the relative intensity of the inherent states making up for the total band profile. For the smaller nanoparticles the difference in the crystal facets are important for the spectral outcome which is also influenced by the surrounding MM environment.

  10. Scaffold microstructure effects on functional and mechanical performance: Integration of theoretical and experimental approaches for bone tissue engineering applications.

    Science.gov (United States)

    Cavo, Marta; Scaglione, Silvia

    2016-11-01

    The really nontrivial goal of tissue engineering is combining all scaffold micro-architectural features, affecting both fluid-dynamical and mechanical performance, to obtain a fully functional implant. In this work we identified an optimal geometrical pattern for bone tissue engineering applications, best balancing several graft needs which correspond to competing design goals. In particular, we investigated the occurred changes in graft behavior by varying pore size (300μm, 600μm, 900μm), interpore distance (equal to pore size or 300μm fixed) and pores interconnection (absent, 45°-oriented, 90°-oriented). Mathematical considerations and Computational Fluid Dynamics (CFD) tools, here combined in a complete theoretical model, were carried out to this aim. Poly-lactic acid (PLA) based samples were realized by 3D printing, basing on the modeled architectures. A collagen (COL) coating was also realized on grafts surface and the interaction between PLA and COL, besides the protein contribution to graft bioactivity, was evaluated. Scaffolds were extensively characterized; human articular cells were used to test their biocompatibility and to evaluate the theoretical model predictions. Grafts fulfilled both the chemical and physical requirements. Finally, a good agreement was found between the theoretical model predictions and the experimental data, making these prototypes good candidates for bone graft replacements.

  11. An integrated quality function deployment and capital budgeting methodology for occupational safety and health as a systems thinking approach: the case of the construction industry.

    Science.gov (United States)

    Bas, Esra

    2014-07-01

    In this paper, an integrated methodology for Quality Function Deployment (QFD) and a 0-1 knapsack model is proposed for occupational safety and health as a systems thinking approach. The House of Quality (HoQ) in QFD methodology is a systematic tool to consider the inter-relationships between two factors. In this paper, three HoQs are used to consider the interrelationships between tasks and hazards, hazards and events, and events and preventive/protective measures. The final priority weights of events are defined by considering their project-specific preliminary weights, probability of occurrence, and effects on the victim and the company. The priority weights of the preventive/protective measures obtained in the last HoQ are fed into a 0-1 knapsack model for the investment decision. Then, the selected preventive/protective measures can be adapted to the task design. The proposed step-by-step methodology can be applied to any stage of a project to design the workplace for occupational safety and health, and continuous improvement for safety is endorsed by the closed loop characteristic of the integrated methodology.

  12. Novel aspects of grapevine response to phytoplasma infection investigated by a proteomic and phospho-proteomic approach with data integration into functional networks

    Directory of Open Access Journals (Sweden)

    Margaria Paolo

    2013-01-01

    Full Text Available Abstract Background Translational and post-translational protein modifications play a key role in the response of plants to pathogen infection. Among the latter, phosphorylation is critical in modulating protein structure, localization and interaction with other partners. In this work, we used a multiplex staining approach with 2D gels to study quantitative changes in the proteome and phosphoproteome of Flavescence dorée-affected and recovered ‘Barbera’ grapevines, compared to healthy plants. Results We identified 48 proteins that differentially changed in abundance, phosphorylation, or both in response to Flavescence dorée phytoplasma infection. Most of them did not show any significant difference in recovered plants, which, by contrast, were characterized by changes in abundance, phosphorylation, or both for 17 proteins not detected in infected plants. Some enzymes involved in the antioxidant response that were up-regulated in infected plants, such as isocitrate dehydrogenase and glutathione S-transferase, returned to healthy-state levels in recovered plants. Others belonging to the same functional category were even down-regulated in recovered plants (oxidoreductase GLYR1 and ascorbate peroxidase. Our proteomic approach thus agreed with previously published biochemical and RT-qPCR data which reported down-regulation of scavenging enzymes and accumulation of H2O2 in recovered plants, possibly suggesting a role for this molecule in remission from infection. Fifteen differentially phosphorylated proteins (| ratio | > 2, p  Conclusions Proteomic data were integrated into biological networks and their interactions were represented through a hypothetical model, showing the effects of protein modulation on primary metabolic ways and related secondary pathways. By following a multiplex-staining approach, we obtained new data on grapevine proteome pathways that specifically change at the phosphorylation level during phytoplasma infection

  13. From integrated control to integrated farming, an experimental approach

    NARCIS (Netherlands)

    Vereijken, P.H.

    1989-01-01

    Integrated control or integrated pest management (IPM), as envisaged originally, is not being practised to any large extent in arable farming, notwithstanding considerable research efforts. The reasons for this are discussed. A more basic approach called integrated farming is suggested. Preliminary

  14. FUPOL: an Integrated Approach to Participative Policies

    Directory of Open Access Journals (Sweden)

    Silvana Tomic Rotim

    2014-05-01

    Full Text Available The Future Policy Modelling Project (FUPOL is a research project funded by the 7th framework program of the European Union. Its research focus are new technologies and methods for e-governance, e-participation and policy modelling. The FUPOL consortium consists of partners from European countries, China and Kenya. and comprises innovative multinational companies, leading research institutes, high-level political organizations as well as strong pilot partners. This paper describes the FUPOL new integrated approach to policy design and implementation including also specific examples from real life pilots in cities from different countries. FUPOL consists of an advanced policy lifecycle and an IT-solution with features supporting all phases of the proposed lifecycle. The FUPOL concept and functional modules as well as the technical architecture to achieve such a complete integration are described.

  15. Stochastic integrals: a combinatorial approach

    OpenAIRE

    Rota, Gian-Carlo; Wallstrom, Timothy C.

    1997-01-01

    A combinatorial definition of multiple stochastic integrals is given in the setting of random measures. It is shown that some properties of such stochastic integrals, formerly known to hold in special cases, are instances of combinatorial identities on the lattice of partitions of a set. The notion of stochastic sequences of binomial type is introduced as a generalization of special polynomial sequences occuring in stochastic integration, such as Hermite, Poisson–Charlier an...

  16. Pediatric asthma: an integrative approach to care.

    Science.gov (United States)

    Mark, John David

    2009-01-01

    Asthma in children and young adults is a complex disease with many different phenotypic expressions. Diagnosis is often made based on history and lung function including measuring airway reversibility. However, in children younger than 6 years of age, the diagnosis is more difficult because many children wheeze in the first 4-6 years of life, especially with viral infections. For those children, asthma treatment is often started empirically. Those who go on to develop chronic asthma most likely have a genetic predisposition and exposure to various environmental factors resulting in chronic inflammation of the lower respiratory tract. There are established national guidelines for diagnosing and treating asthma in children and adults. For persistent asthma, it is recommended that medications be taken on a regular basis after identifying and avoiding environmental triggers. Because many factors play a role in developing asthma in children, many nonmedical approaches to asthma and asthma-like conditions have been promoted even when the diagnosis is at times uncertain. The nonmedical approaches and therapies are often referred to as complementary and alternative medicine (CAM). This review will discuss the conventional therapies recommended for children with asthma in addition to CAM therapies, some of which have supporting scientific evidence. Integrating conventional and CAM therapies can prove to be an effective way to treat pediatric asthma, a common and chronic childhood lung disorder. A case is provided to illustrate how such an integrative approach was used in the successful treatment of a child with moderate persistent asthma.

  17. Adult neurogenesis: integrating theories and separating functions.

    Science.gov (United States)

    Aimone, James B; Deng, Wei; Gage, Fred H

    2010-07-01

    The continuous incorporation of new neurons in the dentate gyrus of the adult hippocampus raises exciting questions about memory and learning, and has inspired new computational models to understand the function of adult neurogenesis. These theoretical approaches suggest distinct roles for new neurons as they slowly integrate into the existing dentate gyrus network: immature adult-born neurons seem to function as pattern integrators of temporally adjacent events, thereby enhancing pattern separation for events separated in time; whereas maturing adult-born neurons possibly contribute to pattern separation by being more amenable to learning new information, leading to dedicated groups of granule cells that respond to experienced environments. We review these hypothesized functions and supporting empirical research and point to new directions for future theoretical efforts.

  18. Integrated approach to economical, reliable, safe nuclear power production

    Energy Technology Data Exchange (ETDEWEB)

    1982-06-01

    An Integrated Approach to Economical, Reliable, Safe Nuclear Power Production is the latest evolution of a concept which originated with the Defense-in-Depth philosophy of the nuclear industry. As Defense-in-Depth provided a framework for viewing physical barriers and equipment redundancy, the Integrated Approach gives a framework for viewing nuclear power production in terms of functions and institutions. In the Integrated Approach, four plant Goals are defined (Normal Operation, Core and Plant Protection, Containment Integrity and Emergency Preparedness) with the attendant Functional and Institutional Classifications that support them. The Integrated Approach provides a systematic perspective that combines the economic objective of reliable power production with the safety objective of consistent, controlled plant operation.

  19. Integration of Genomic, Biologic, and Chemical Approaches to Target p53 Loss and Gain-of-Function in Triple Negative Breast Cancer

    Science.gov (United States)

    2014-09-01

    Approaches to Target p53 Loss and Gain-of-Function in Triple Negative Breast Cancer PRINCIPAL INVESTIGATOR: Jennifer A. Pietenpol, Ph.D...Biologic, and Chemical Approaches to Target p53 Loss and Gain-of-Function in Triple Negative Breast Cancer 5a. CONTRACT NUMBER...states resulting from alterations in the p53 signaling pathway in triple negative breast cancer (TNBC). Development of therapies for TNBC is a

  20. Caprock integrity analysis in thermal operations: an integrated geomechanics approach

    Energy Technology Data Exchange (ETDEWEB)

    Khan, Safdar; Han, Hongxue; Ansari, Sajjad; Vishteh, Morteza; Khosravi, Nader [Schlumberger Data and Consulting Services (Canada)

    2011-07-01

    In heavy oil fields, thermal processes such as steam assisted gravity drainage (SAGD) and cyclic steam simulation (CSS) are used to recover oil. Unfortunately these methods can induce problems of caprock integrity. It is commonly thought that to maintain caprock integrity, the net injection pressure should be kept under the fracture pressure as measured by mini-fracturing tests but cases have shown that failures can occur below this pressure. This paper aimed at presenting a new approach based on geomechanics to evaluate caprock integrity in thermal processes. A study case was conducted on an SAGD pad development in Northern Alberta. Results confirmed that caprock integrity cannot be guaranteed by injecting steam at a pressure lower than the fracture pressure. In addition the geomechanical model can be used to take measures to avoid catastrophic events. A new integrated geomechanical approach for caprock integrity in thermal operations was developed herein and successfully tested in a field study.

  1. Integrated design approach for controlled mechanical structures

    Energy Technology Data Exchange (ETDEWEB)

    Kiriazov, P. [Bulgarian Academy of Sciences, Sofia (Bulgaria). Inst. of Mechanics

    1998-10-01

    This study is addressed to design problems of controlled mechanical structures (CMS) like robot manipulators and engineering systems with active vibration control that may be subject to arbitrary disturbances. Along with the basic design requirement for strength/load capacity, additional design criteria for CMS are needed to meet the continuously increasing demands for faster response, improved precision and reduced energy consumption. As a CMS is a functionally directed assembly of mutually influencing components: control, actuator, mechanical, and sensor subsystems, a conceptual framework for their integrated design is required. Parameters of these subsystems influencing the dynamic performance of CMS define a matrix that transfers the control inputs into the controlled outputs (accelerations). This transfer matrix plays the key role in the integrated structure-control design. We consider the design optimization problem for CMS having decentralized control architecture. An integrated design criterion for such systems is proposed which is based on optimal trade-off relations between bounds of model uncertainties and control force limits. Optimizing this criterion leads to CMS with maximum degree of robustness. The approach proposed makes it possible a decomposition of the overall design problem into design problems for the CMS`s components. The design concepts are applied to the mechanical subsystem of planar linkage systems. Robust decentralized controllers are designed for a two-degree-of-freedom manipulator with elastic joints. (orig.)

  2. Path Integral Approach to Atomic Collisions

    Science.gov (United States)

    Harris, Allison

    2016-09-01

    The Path Integral technique is an alternative formulation of quantum mechanics that is based on a Lagrangian approach. In its exact form, it is completely equivalent to the Hamiltonian-based Schrödinger equation approach. Developed by Feynman in the 1940's, following inspiration from Dirac, the path integral approach has been widely used in high energy physics, quantum field theory, and statistical mechanics. However, only in limited cases has the path integral approach been applied to quantum mechanical few-body scattering. We present a theoretical and computational development of the path integral method for use in the study of atomic collisions. Preliminary results are presented for some simple systems. Ultimately, this approach will be applied to few-body ion-atom collisions. Work supported by NSF grant PHY-1505217.

  3. Operationalizing the integrated landscape approach in practice

    Directory of Open Access Journals (Sweden)

    Olivia E. Freeman

    2015-03-01

    the process of taking a landscape approach. Drawing on a review of the literature, we identify and discuss three different kinds of landscape approaches: using the landscape scale, a sectoral landscape approach, and an integrated landscape approach. Focusing on an integrated landscape approach, we examine five concepts to help characterize landscape approaches: multifunctionality, transdisciplinarity, participation, complexity, and sustainability. For each term, a continuum of application exists. To help improve and move the integrated landscape approach more toward operationalization, more focus needs to be placed on the process of taking the approach. Although the process can be implemented in a range of ways, in a more integrated approach it will require explicitly defined objectives as well as a clear understanding of what is meant by multifunctionality and sustainability. It will also require collaborative participation, transdisciplinarity/cross-sectoral approaches, managing for adaptive capacity, and applying an iterative process to address the inherent complexity within the system. Although these concepts are not new, we present continuums on which they can exist, allowing for clarification and distinctions to be made regarding what it means to take a landscape approach.

  4. Counting master integrals. Integration by parts vs. functional equations

    Energy Technology Data Exchange (ETDEWEB)

    Kniehl, Bernd A.; Tarasov, Oleg V. [Hamburg Univ. (Germany). II. Inst. fuer Theoretische Physik

    2016-01-15

    We illustrate the usefulness of functional equations in establishing relationships between master integrals under the integration-by-parts reduction procedure by considering a certain two-loop propagator-type diagram as an example.

  5. Evaluating Pain Education Programs: An Integrated Approach

    Directory of Open Access Journals (Sweden)

    Adam Dubrowski

    2011-01-01

    Full Text Available Evaluation of educational programs and assessment of learning are essential to maintain high-standard health science education, which includes pain education. Current models of program evaluations applied to the education of the health professions, such as the Kirkpatrick model, are mainly outcome based. More recently, efforts have been made to examine other process-based models such as the Context Input Process Product model. The present article proposes an approach that integrates both outcome- and process-based models with models of clinical performance assessment to provide a deeper understanding of a program function. Because assessment instruments are a critical part of program evaluation, it is suggested that standardization and rigour should be used in their selection, development and adaptation. The present article suggests an alternative to currently used models in pain education evaluation.

  6. Integral operators and univalent functions

    Directory of Open Access Journals (Sweden)

    Kiah Wah Ong

    2012-06-01

    Full Text Available In this paper, we define two new integral operators $L^k$ and $L_k$ which are iterative in nature. We show that for $f(z=z+a_2z^2+ \\cdots +a_nz^n +\\cdots$ with radius of convergence larger than one, $L^kf(z$ and $L_kf(z$ when restricted on $E=\\{z:|z|<1\\}$ will eventually be univalent for large enough $k$. We then show that these are the best possible results by demonstrating that there exists a holomorphic function $T(z$ in normalized form and with radius of convergence equal to one such that $L^kT(z$ and $L_kT(z$ fail to be univalent when restricted to $E$ for every $k\\in \\mathbb{N}$.

  7. Teaching Online: An Integrated Approach

    Science.gov (United States)

    Thomas, Christian

    2012-03-01

    Teaching online is becoming more popular and many web-based tools are available for both traditional and online courses. Web applets, videos, hi-resolution images, c. are available to illustrate and reinforce content. Most are generally used as separate material in the classroom or from a separate web page, not tied directly to the course text. Web pages amalgamate resources based on topics, but are generally not directly linked to the material covered in a textbook. Some textbooks come with separate CDROMs containing extra materials, but these are an add-on. I will present an example of an integrated course text with materials linked directly into the text. This method allows students to look at the illustration at the appropriate time --- when it is relevant to the material they are reading. I will also discuss the benefits of using these materials in an introductory astronomy course.

  8. Integrated approach to optomechanical system development

    Science.gov (United States)

    Reney, Thomas E.; Wiggins, Richard L.; Comstock, Lovell E.; Santman, Jeffry J.; Woodard, Kenneth S.

    2011-06-01

    Over the past few decades of computer aided engineering growth there has been much more progress in increasing the power and capability of function specific engineering tools (e.g., optical design, finite element analysis, etc.) than in the integration of and communication between these tools. With only a few notable exceptions, such as FEA being imbedded into solid modeling, the communication method between the function specific tools continues to be dominated by translation to neutral data formats (e.g., IGES, STEP) and file transfer. There are a number of problems with this approach. The translation is a serial process where an engineer has to stop at some point in the design, make the neutral file, send that file to the next function, and wait for feedback. The translation through a neutral format is typically one way so the whole translation process has to be repeated when changes are required. Revision tracking of multiple files for each design iteration is both critical and a likely source of errors. Also, as with any translation, some information is always lost or corrupted in the process. This paper describes some progress that has been made in more tightly integrating optical design, mechanical design, fabrication, and testing of optical systems. Tools have been developed that connect CODE V®[1] to SolidWorks®[2] (bidirectional), compensation of diamond turning CNC from interferometric data, slope analysis from interferometer and profilometer data, and other tools for wavefront error compensation, and electronic nulls. Design, machining, testing and inspection efficiency gains are achieved through tools that consume mechanical solid models in their native format.

  9. An integral approach to substance abuse.

    Science.gov (United States)

    Amodia, Diana S; Cano, Carol; Eliason, Michele J

    2005-12-01

    There is a pressing need in the substance abuse field for more comprehensive models of etiology and treatment that address the complex issues of addiction, including the biological, social, cultural, spiritual and developmental needs of individuals and groups. This article presents a theoretical framework for an integral approach to substance abuse that expands on the existing biopsychosocial model. One contribution of the model is an integrated approach to spirituality from a cross-cultural perspective. This integral approach examines substance abuse etiology and treatment from a four-quadrant perspective adapted from the work of Ken Wilber, and incorporates concepts from integrative medicine and transpersonal psychology/psychiatry. Implications of the model are explored.

  10. Integrated Approaches On Archaeo-Geophysical Data

    Science.gov (United States)

    Kucukdemirci, M.; Piro, S.; Zamuner, D.; Ozer, E.

    2015-12-01

    Key words: Ground Penetrating Radar (GPR), Magnetometry, Geophysical Data Integration, Principal Component Analyse (PCA), Aizanoi Archaeological Site An application of geophysical integration methods which often appealed are divided into two classes as qualitative and quantitative approaches. This work focused on the application of quantitative integration approaches, which involve the mathematical and statistical integration techniques, on the archaeo-geophysical data obtained in Aizanoi Archaeological Site,Turkey. Two geophysical methods were applied as Ground Penetrating Radar (GPR) and Magnetometry for archaeological prospection on the selected archaeological site. After basic data processing of each geophysical method, the mathematical approaches of Sums and Products and the statistical approach of Principal Component Analysis (PCA) have been applied for the integration. These integration approches were first tested on synthetic digital images before application to field data. Then the same approaches were applied to 2D magnetic maps and 2D GPR time slices which were obtained on the same unit grids in the archaeological site. Initially, the geophysical data were examined individually by referencing with archeological maps and informations obtained from archaeologists and some important structures as possible walls, roads and relics were determined. The results of all integration approaches provided very important and different details about the anomalies related to archaeological features. By using all those applications, integrated images can provide complementary informations as well about the archaeological relics under the ground. Acknowledgements The authors would like to thanks to Scientific and Technological Research Council of Turkey (TUBITAK), Fellowship for Visiting Scientists Programme for their support, Istanbul University Scientific Research Project Fund, (Project.No:12302) and archaeologist team of Aizanoi Archaeological site for their support

  11. Integrated approach to advanced machining

    Energy Technology Data Exchange (ETDEWEB)

    LeSar, R.A.; Bourke, M.A.M.; Rangaswamy, P.; Day, R.D.; Hatch, D.J.

    1997-08-01

    The residual stress state induced by machining in a Ti alloy as function of cutting tool sharpness and depth of cut was predicted and measured. Residual stresses were greater for the dull tool than for the sharp tool. XRD was used to measure the residual stress state of the material; these measurements revealed that the hoop stress increased with depth of cut; however the radial stress decreased with depth of cut. An elastic-plastic model provided a possible explanation for this behavior in that, for small depths of cut, the tool makes multiple passes through the damage subsurface layer. This causes both residual stress components to increase, but the radial stress increases by a much greater amount than the hoop stress.

  12. Integrating Communicative Approaches with Traditional Approaches in ELT

    Institute of Scientific and Technical Information of China (English)

    陈超

    2013-01-01

    Traditional y, English teaching in China is dominated by a teacher-centered, grammar-translation and audio-lingual method and an emphasis on rote learning. In an attempt to find out what are the most appropriate teaching methods for Chinese students in schools, the paper presents that the best method is to integrate communicative approaches to the teaching of English with traditional Chinese methods. It shows that integrating communicative approaches with the traditional approaches can real y help the students develop their communicative competence.

  13. Graph-based sequence annotation using a data integration approach.

    Science.gov (United States)

    Pesch, Robert; Lysenko, Artem; Hindle, Matthew; Hassani-Pak, Keywan; Thiele, Ralf; Rawlings, Christopher; Köhler, Jacob; Taubert, Jan

    2008-08-25

    The automated annotation of data from high throughput sequencing and genomics experiments is a significant challenge for bioinformatics. Most current approaches rely on sequential pipelines of gene finding and gene function prediction methods that annotate a gene with information from different reference data sources. Each function prediction method contributes evidence supporting a functional assignment. Such approaches generally ignore the links between the information in the reference datasets. These links, however, are valuable for assessing the plausibility of a function assignment and can be used to evaluate the confidence in a prediction. We are working towards a novel annotation system that uses the network of information supporting the function assignment to enrich the annotation process for use by expert curators and predicting the function of previously unannotated genes. In this paper we describe our success in the first stages of this development. We present the data integration steps that are needed to create the core database of integrated reference databases (UniProt, PFAM, PDB, GO and the pathway database Ara-Cyc) which has been established in the ONDEX data integration system. We also present a comparison between different methods for integration of GO terms as part of the function assignment pipeline and discuss the consequences of this analysis for improving the accuracy of gene function annotation. The methods and algorithms presented in this publication are an integral part of the ONDEX system which is freely available from http://ondex.sf.net/.

  14. A knowledge integration approach to flood vulnerability

    Science.gov (United States)

    Mazzorana, Bruno; Fuchs, Sven

    2014-05-01

    Understanding, qualifying and quantifying vulnerability is an essential need for implementing effective and efficient flood risk mitigation strategies; in particular if possible synergies between different mitigation alternatives, such as active and passive measures, should be achieved. In order to combine different risk management options it is necessary to take an interdisciplinary approach to vulnerability reduction, and as a result the affected society may be willing to accept a certain degree of self-responsibility. However, due to differing mono-disciplinary approaches and regional foci undertaken until now, different aspects of vulnerability to natural hazards in general and to floods in particular remain uncovered and as a result the developed management options remain sub-optimal. Taking an even more fundamental viewpoint, the empirical vulnerability functions used in risk assessment specifically fail to capture physical principles of the damage-generating mechanisms to the build environment. The aim of this paper is to partially close this gap by discussing a balanced knowledge integration approach which can be used to resolve the multidisciplinary disorder in flood vulnerability research. Modelling techniques such as mathematical-physical modelling of the flood hazard impact to and response from the building envelope affected, and formative scenario analyses of possible consequences in terms of damage and loss are used in synergy to provide an enhanced understanding of vulnerability and to render the derived knowledge into interdisciplinary mitigation strategies. The outlined formal procedure allows for a convincing knowledge alignment of quantified, but partial, information about vulnerability as a result of the application of physical and engineering notions and valuable, but often underspecified, qualitative argumentation strings emerging from the adopted socio-economic viewpoint.

  15. An integrated approach to stakeholder engagement.

    Science.gov (United States)

    Carr, Dafna; Howells, Arlene; Chang, Melissa; Hirji, Nadir; English, Ann

    2009-01-01

    The Wait Time Information System (WTIS) project was a complex change-management initiative. For the first time in Ontario, wait time data would be captured directly from clinician offices and publicly reported in an effort to improve access to care. The change meant using new technology, new business processes and, most importantly, a new dimension of accountability for making improvements within the health system. Success required engaging thousands of individuals at all levels of healthcare, many of whom were skeptical and resistant to the upcoming change, and subsequently gaining their support and motivating them to use the WTIS and its data. To achieve the level of stakeholder engagement that would be required to deploy and sustain the WTIS, the project team needed to address both the business reasons for change, and the emotional reactions to it. The team applied a three-pronged approach encompassing strong communications, compelling adoption efforts and hands-on training. Communication focused on awareness and education, ensuring that information was coordinated, consistent and transparent. Adoption efforts involved helping hospitals and users understand and prepare for the impact of change. Training provided hands-on practice to get people comfortable with using the system. This article explores how information management/information technology (IM/IT) projects can integrate communications, adoption and training to drive stakeholder engagement. It also provides insight around how, when used effectively, these functions can maximize limited resources and provide valuable benefits.

  16. Mutation-Structure-Function Relationship Based Integrated Strategy Reveals the Potential Impact of Deleterious Missense Mutations in Autophagy Related Proteins on Hepatocellular Carcinoma (HCC: A Comprehensive Informatics Approach

    Directory of Open Access Journals (Sweden)

    Faryal Mehwish Awan

    2017-01-01

    Full Text Available Autophagy, an evolutionary conserved multifaceted lysosome-mediated bulk degradation system, plays a vital role in liver pathologies including hepatocellular carcinoma (HCC. Post-translational modifications (PTMs and genetic variations in autophagy components have emerged as significant determinants of autophagy related proteins. Identification of a comprehensive spectrum of genetic variations and PTMs of autophagy related proteins and their impact at molecular level will greatly expand our understanding of autophagy based regulation. In this study, we attempted to identify high risk missense mutations that are highly damaging to the structure as well as function of autophagy related proteins including LC3A, LC3B, BECN1 and SCD1. Number of putative structural and functional residues, including several sites that undergo PTMs were also identified. In total, 16 high-risk SNPs in LC3A, 18 in LC3B, 40 in BECN1 and 43 in SCD1 were prioritized. Out of these, 2 in LC3A (K49A, K51A, 1 in LC3B (S92C, 6 in BECN1 (S113R, R292C, R292H, Y338C, S346Y, Y352H and 6 in SCD1 (Y41C, Y55D, R131W, R135Q, R135W, Y151C coincide with potential PTM sites. Our integrated analysis found LC3B Y113C, BECN1 I403T, SCD1 R126S and SCD1 Y218C as highly deleterious HCC-associated mutations. This study is the first extensive in silico mutational analysis of the LC3A, LC3B, BECN1 and SCD1 proteins. We hope that the observed results will be a valuable resource for in-depth mechanistic insight into future investigations of pathological missense SNPs using an integrated computational platform.

  17. Advancing Instructional Communication: Integrating a Biosocial Approach

    Science.gov (United States)

    Horan, Sean M.; Afifi, Tamara D.

    2014-01-01

    Celebrating 100 years of the National Communication Association necessitates that, as we commemorate our past, we also look toward our future. As part of a larger conversation about the future of instructional communication, this essay reinvestigates the importance of integrating biosocial approaches into instructional communication research. In…

  18. The Foresee Approach to Integrated ESL Instruction.

    Science.gov (United States)

    Kidd, Richard; Marquardson, Brenda

    1997-01-01

    Describes the Foresee Approach to integrating academic content, language, and learning instruction in English as a Second Language (ESL) from kindergarten to grade 12 or in mainstream/part ESL classrooms. The Foresee Model includes theoretical and practical constituents and guides the formulation of instructional objectives in the three target…

  19. Integrated Approach to User Account Management

    Science.gov (United States)

    Kesselman, Glenn; Smith, William

    2007-01-01

    IT environments consist of both Windows and other platforms. Providing user account management for this model has become increasingly diffi cult. If Microsoft#s Active Directory could be enhanced to extend a W indows identity for authentication services for Unix, Linux, Java and Macintosh systems, then an integrated approach to user account manag ement could be realized.

  20. Integration of the Quadratic Function and Generalization

    Science.gov (United States)

    Mitsuma, Kunio

    2011-01-01

    We will first recall useful formulas in integration that simplify the calculation of certain definite integrals with the quadratic function. A main formula relies only on the coefficients of the function. We will then explore a geometric proof of one of these formulas. Finally, we will extend the formulas to more general cases. (Contains 3…

  1. Suppression subtractive hybridization (SSH) combined with bioinformatics method: an integrated functional annotation approach for analysis of differentially expressed immune-genes in insects.

    Science.gov (United States)

    Badapanda, Chandan

    2013-01-01

    The suppression subtractive hybridization (SSH) approach, a PCR based approach which amplifies differentially expressed cDNAs (complementary DNAs), while simultaneously suppressing amplification of common cDNAs, was employed to identify immuneinducible genes in insects. This technique has been used as a suitable tool for experimental identification of novel genes in eukaryotes as well as prokaryotes; whose genomes have been sequenced, or the species whose genomes have yet to be sequenced. In this article, I have proposed a method for in silico functional characterization of immune-inducible genes from insects. Apart from immune-inducible genes from insects, this method can be applied for the analysis of genes from other species, starting from bacteria to plants and animals. This article is provided with a background of SSH-based method taking specific examples from innate immune-inducible genes in insects, and subsequently a bioinformatics pipeline is proposed for functional characterization of newly sequenced genes. The proposed workflow presented here, can also be applied for any newly sequenced species generated from Next Generation Sequencing (NGS) platforms.

  2. A path integral approach to asset-liability management

    NARCIS (Netherlands)

    Decamps, M.; de Schepper, A.; Goovaerts, M.J.

    2006-01-01

    Functional integrals constitute a powerful tool in the investigation of financial models. In the recent econophysics literature, this technique was successfully used for the pricing of a number of derivative securities. In the present contribution, we introduce this approach to the field of asset-li

  3. An evolutionary approach to Function.

    Science.gov (United States)

    Lord, Phillip

    2010-06-22

    Understanding the distinction between function and role is vexing and difficult. While it appears to be useful, in practice this distinction is hard to apply, particularly within biology. I take an evolutionary approach, considering a series of examples, to develop and generate definitions for these concepts. I test them in practice against the Ontology for Biomedical Investigations (OBI). Finally, I give an axiomatisation and discuss methods for applying these definitions in practice. The definitions in this paper are applicable, formalizing current practice. As such, they make a significant contribution to the use of these concepts within biomedical ontologies.

  4. An evolutionary approach to Function

    Directory of Open Access Journals (Sweden)

    Lord Phillip

    2010-06-01

    Full Text Available Abstract Background Understanding the distinction between function and role is vexing and difficult. While it appears to be useful, in practice this distinction is hard to apply, particularly within biology. Results I take an evolutionary approach, considering a series of examples, to develop and generate definitions for these concepts. I test them in practice against the Ontology for Biomedical Investigations (OBI. Finally, I give an axiomatisation and discuss methods for applying these definitions in practice. Conclusions The definitions in this paper are applicable, formalizing current practice. As such, they make a significant contribution to the use of these concepts within biomedical ontologies.

  5. Defining Integrals Over Connections in the Discretized Gravitational Functional Integrals

    Science.gov (United States)

    Khatsymovsky, V. M.

    Integration over connection type variables in the path integral for the discrete form of the first-order formulation of general relativity theory is studied. The result (a generalized function of the rest of variables of the type of tetrad or elementary areas) can be defined through its moments, i.e. integrals of it with the area tensor monomials. In our previous paper these moments have been defined by deforming integration contours in the complex plane as if we had passed to a Euclidean-like region. In this paper we define and evaluate the moments in the genuine Minkowski region. The distribution of interest resulting from these moments in this non-positively defined region contains the divergences. We prove that the latter contribute only to the singular (δ-function like) part of this distribution with support in the non-physical region of the complex plane of area tensors while in the physical region this distribution (usual function) confirms that defined in our previous paper which decays exponentially at large areas. Besides that, we evaluate the basic integrals over which the integral over connections in the general path integral can be expanded.

  6. Boundary conditions: The path integral approach

    Energy Technology Data Exchange (ETDEWEB)

    Asorey, M [Departamento de Fisica Teorica, Universidad de Zaragoza 50009 Zaragoza (Spain); Clemente-Gallardo, J [BIFI, Universidad de Zaragoza, 50009 Zaragoza (Spain); Munoz-Castaneda, J M [Departamento de Fisica Teorica, Universidad de Zaragoza 50009 Zaragoza (Spain)

    2007-11-15

    The path integral approach to quantum mechanics requires a substantial generalisation to describe the dynamics of systems confined to bounded domains. Nonlocal boundary conditions can be introduced in Feynman's approach by means of boundary amplitude distributions and complex phases to describe the quantum dynamics in terms of the classical trajectories. The different prescriptions involve only trajectories reaching the boundary and correspond to different choices of boundary conditions of selfadjoint extensions of the Hamiltonian. One dimensional particle dynamics is analysed in detail.

  7. ENPEP: An integrated approach to energy planning

    Energy Technology Data Exchange (ETDEWEB)

    Hamilton, B.P.; Cirillo, R.R.; Buehring, W.A.

    1992-01-01

    Many models have been developed to analyze various aspects of the energy system. The Energy and Power Evaluation Program (ENPEP) is a set of microcomputer-based energy planning tools that are designed to provide an integrated analysis capability. ENPEP begins with a macroeconomic analysis, develops an energy demand forecast based on this analysis, carries out an integrated supply/demand analysis for the entire energy system, evaluates the electric system component of the energy system in detail, and determines the impacts of alternative configurations. This approach is an enhancement of existing techniques in that it places emphasis on looking at the electric system as an integral part of the entire energy supply system. Also, it explicitly considers the impacts the power system has on the rest of the energy system and on the economy as a whole.

  8. ENPEP: An integrated approach to energy planning

    Energy Technology Data Exchange (ETDEWEB)

    Hamilton, B.P.; Cirillo, R.R.; Buehring, W.A.

    1992-09-01

    Many models have been developed to analyze various aspects of the energy system. The Energy and Power Evaluation Program (ENPEP) is a set of microcomputer-based energy planning tools that are designed to provide an integrated analysis capability. ENPEP begins with a macroeconomic analysis, develops an energy demand forecast based on this analysis, carries out an integrated supply/demand analysis for the entire energy system, evaluates the electric system component of the energy system in detail, and determines the impacts of alternative configurations. This approach is an enhancement of existing techniques in that it places emphasis on looking at the electric system as an integral part of the entire energy supply system. Also, it explicitly considers the impacts the power system has on the rest of the energy system and on the economy as a whole.

  9. Introduction to solid mechanics an integrated approach

    CERN Document Server

    Lubliner, Jacob

    2017-01-01

    This expanded second edition presents in one text the concepts and processes covered in statics and mechanics of materials curricula following a systematic, topically integrated approach. Building on the novel pedagogy of fusing concepts covered in traditional undergraduate courses in rigid-body statics and deformable body mechanics, rather than simply grafting them together, this new edition develops further the authors’ very original treatment of solid mechanics with additional figures, an elaboration on selected solved problems, and additional text as well as a new subsection on viscoelasticity in response to students’ feedback. Introduction to Solid Mechanics: An Integrated Approach, Second Edition, offers a holistic treatment of the depth and breadth of solid mechanics and the inter-relationships of its underlying concepts. Proceeding from first principles to applications, the book stands as a whole greater than the sum of its parts.  .

  10. Control theory and psychopathology: an integrative approach.

    Science.gov (United States)

    Mansell, Warren

    2005-06-01

    Perceptual control theory (PCT; Powers, 1973) is presented and adapted as a framework to understand the causes, maintenance, and treatment of psychological disorders. PCT provides dynamic, working models based on the principle that goal-directed activity arises from a hierarchy of negative feedback loops that control perception through control of the environment. The theory proposes that psychological distress arises from the unresolved conflict between goals. The present paper integrates PCT, control theory, and self-regulatory approaches to psychopathology and psychotherapy and recent empirical findings, particularly in the field of cognitive therapy. The approach aims to offer fresh insights into the role of goal conflict, automatic processes, imagery, perceptual distortion, and loss of control in psychological disorders. Implications for psychological therapy are discussed, including an integration of the existing work on the assessment of control profiles and the use of assertive versus yielding modes of control.

  11. Approaches to Integrated Building Design Environments

    DEFF Research Database (Denmark)

    Bagger-Petersen, Susanne C; Andersen, Tom

    1996-01-01

    This report discusses functional requirements and specification which needs to be defined and fulfilled to initiate development of an integrated building design environment. The purpose is to outline specifications for further discussion and development. The report documents the first phase...... in an ongoing project at the Technical University of Denmark. The overall project objective is to provide a theoretically well-founded prototype of an integrated IT-system which can serve as a device of feedback from practice and as a test-bed for the developed concept and architecture....

  12. Efficient integration method for fictitious domain approaches

    Science.gov (United States)

    Duczek, Sascha; Gabbert, Ulrich

    2015-10-01

    In the current article, we present an efficient and accurate numerical method for the integration of the system matrices in fictitious domain approaches such as the finite cell method (FCM). In the framework of the FCM, the physical domain is embedded in a geometrically larger domain of simple shape which is discretized using a regular Cartesian grid of cells. Therefore, a spacetree-based adaptive quadrature technique is normally deployed to resolve the geometry of the structure. Depending on the complexity of the structure under investigation this method accounts for most of the computational effort. To reduce the computational costs for computing the system matrices an efficient quadrature scheme based on the divergence theorem (Gauß-Ostrogradsky theorem) is proposed. Using this theorem the dimension of the integral is reduced by one, i.e. instead of solving the integral for the whole domain only its contour needs to be considered. In the current paper, we present the general principles of the integration method and its implementation. The results to several two-dimensional benchmark problems highlight its properties. The efficiency of the proposed method is compared to conventional spacetree-based integration techniques.

  13. Some integral inequalities for logarithmically convex functions

    Directory of Open Access Journals (Sweden)

    Mevlüt Tunç

    2014-07-01

    Full Text Available The main aim of the present note is to establish new Hadamard like integral inequalities involving log-convex function. We also prove some Hadamard-type inequalities, and applications to the special means are given.

  14. Numerical approach to multi-loop integrals

    CERN Document Server

    Kato, K; Hamaguchi, N; Ishikawa, T; Koike, T; Kurihara, Y; Shimizu, Y; Yuasa, F

    2012-01-01

    For the calculation of multi-loop Feynman integrals, a novel numerical method, the Direct Computation Method (DCM) is developed. It is a combination of a numerical integration and a series extrapolation. In principle, DCM can handle diagrams of arbitrary internal masses and external momenta, and can calculate integrals with general numerator function. As an example of the performance of DCM, a numerical computation of two-loop box diagrams is presented. Further discussion is given on the choice of control parameters in DCM. This method will be an indispensable tool for the higher order radiative correction when it is tested for a wider class of physical parameters and the separation of divergence is done automatically.

  15. ZEROES OF GENERALIZED FRESNEL COMPLEMENTARY INTEGRAL FUNCTIONS

    Directory of Open Access Journals (Sweden)

    Jaime Lobo Segura

    2016-08-01

    Full Text Available Theoretical upper and lower bounds are established for zeroes of a parametric family of functions which are defined by integrals of the same type as the Fresnel complementary integral. Asymptotic properties for these bounds are obtained as well as monotony properties of the localization intervals. Given the value of the parameter an analytical-numerical procedure is deduced to enclose all zeros of a given function with an a priori error.

  16. Multimodal functional neuroimaging: integrating functional MRI and EEG/MEG.

    Science.gov (United States)

    He, Bin; Liu, Zhongming

    2008-01-01

    Noninvasive functional neuroimaging, as an important tool for basic neuroscience research and clinical diagnosis, continues to face the need of improving the spatial and temporal resolution. While existing neuroimaging modalities might approach their limits in imaging capability mostly due to fundamental as well as technical reasons, it becomes increasingly attractive to integrate multiple complementary modalities in an attempt to significantly enhance the spatiotemporal resolution that cannot be achieved by any modality individually. Electrophysiological and hemodynamic/metabolic signals reflect distinct but closely coupled aspects of the underlying neural activity. Combining fMRI and EEG/MEG data allows us to study brain function from different perspectives. In this review, we start with an overview of the physiological origins of EEG/MEG and fMRI, as well as their fundamental biophysics and imaging principles, we proceed with a review of the major advances in the understanding and modeling of neurovascular coupling and in the methodologies for the fMRI-EEG/MEG simultaneous recording. Finally, we summarize important remaining issues and perspectives concerning multimodal functional neuroimaging, including brain connectivity imaging.

  17. Integrated approach for hybrid rocket technology development

    Science.gov (United States)

    Barato, Francesco; Bellomo, Nicolas; Pavarin, Daniele

    2016-11-01

    Hybrid rocket motors tend generally to be simple from a mechanical point of view but difficult to optimize because of their complex and still not well understood cross-coupled physics. This paper addresses the previous issue presenting the integrated approach established at University of Padua to develop hybrid rocket based systems. The methodology tightly combines together system analysis and design, numerical modeling from elementary to sophisticated CFD, and experimental testing done with incremental philosophy. As an example of the approach, the paper presents the experience done in the successful development of a hybrid rocket booster designed for rocket assisted take off operations. It is thought that following the proposed approach and selecting carefully the most promising applications it is possible to finally exploit the major advantages of hybrid rocket motors as safety, simplicity, low cost and reliability.

  18. SOA approach for integration of departmental systems.

    Science.gov (United States)

    Itälä, Timo; Ukkola, Jari; Virtanen, Aino; Mykkänen, Juha

    2008-01-01

    In this paper a unified method for integration of departmental systems into the main systems of a healthcare organization is described. The approach is based on combining Business Process Modeling (BPM) and Service Oriented Architecture (SOA) methods and technologies. A top-down approach is used for modeling the care process and supporting care services which in turn are decomposed down to such a level of granularity that they can be described and implemented as web services described with Web Services Description Language (WSDL) documents. Then a bottom-up approach is used for wrapping the existing departmental systems and their interfaces into web services using Enterprise Service Bus (ESB). Finally the orchestration of the services is described using executable Business Process Execution Language (BPEL) code.

  19. A Path Integral Approach To Noncommutative Superspace

    CERN Document Server

    Chepelev, I; Chepelev, Iouri; Ciocarlie, Calin

    2003-01-01

    A path integral formula for the associative star-product of two superfields is proposed. It is a generalization of the Kontsevich-Cattaneo-Felder's formula for the star-product of functions of bosonic coordinates. The associativity of the star-product imposes certain conditions on the background of our sigma model. For generic background the action is not supersymmetric. The supersymmetry invariance of the action constrains the background and leads to a simple formula for the star-product.

  20. Affect integration and reflective function: clarification of central conceptual issues.

    Science.gov (United States)

    Solbakken, Ole André; Hansen, Roger Sandvik; Monsen, Jon Trygve

    2011-07-01

    The importance of affect regulation, modulation or integration for higher-order reflection and adequate functioning is increasingly emphasized across different therapeutic approaches and theories of change. These processes are probably central to any psychotherapeutic endeavor, whether explicitly conceptualized or not, and in recent years a number of therapeutic approaches have been developed that explicitly target them as a primary area of change. However, there still is important lack of clarity in the field regarding the understanding and operationalization of affect integration, particularly when it comes to specifying underlying mechanisms, the significance of different affect states, and the establishment of operational criteria for measurement. The conceptual relationship between affect integration and reflective function thus remains ambiguous. The present article addresses these topics, indicating ways in which a more complex and exhaustive understanding of integration of affect, cognition and behavior can be attained.

  1. Integrating functional oxides with graphene

    Science.gov (United States)

    Hong, X.; Zou, K.; DaSilva, A. M.; Ahn, C. H.; Zhu, J.

    2012-08-01

    Graphene-oxide hybrid structures offer the opportunity to combine the versatile functionalities of oxides with the excellent electronic transport in graphene. Understanding and controlling how the dielectric environment affects the intrinsic properties of graphene is also critical to fundamental studies and technological development of graphene. Here we review our recent effort on understanding the transport properties of graphene interfaced with ferroelectric Pb(Zr,Ti)O3 (PZT) and high-κ HfO2. Graphene field effect devices prepared on high-quality single crystal PZT substrates exhibit up to tenfold increases in mobility compared to SiO2-gated devices. An unusual and robust resistance hysteresis is observed in these samples, which is attributed to the complex surface chemistry of the ferroelectric. Surface polar optical phonons of oxides in graphene transistors play an important role in the device performance. We review their effects on mobility and the high source-drain bias saturation current of graphene, which are crucial for developing graphene-based room temperature high-speed amplifiers. Oxides also introduce scattering sources that limit the low temperature electron mobility in graphene. We present a comprehensive study of the transport and quantum scattering times to differentiate various scattering scenarios and quantitatively evaluate the density and distribution of charged impurities and the effect of dielectric screening. Our results can facilitate the design of multifunctional nano-devices utilizing graphene-oxide hybrid structures.

  2. Toward a quantitative approach to migrants integration

    Science.gov (United States)

    Barra, A.; Contucci, P.

    2010-03-01

    Migration phenomena and all the related issues, like integration of different social groups, are intrinsically complex problems since they strongly depend on several competitive mechanisms as economic factors, cultural differences and many others. By identifying a few essential assumptions, and using the statistical mechanics of complex systems, we propose a novel quantitative approach that provides a minimal theory for those phenomena. We show that the competitive interactions in decision making between a population of N host citizens and P immigrants, a bi-partite spin-glass, give rise to a social consciousness inside the host community in the sense of the associative memory of neural networks. The theory leads to a natural quantitative definition of migrant's "integration" inside the community. From the technical point of view this minimal picture assumes, as control parameters, only general notions like the strength of the random interactions, the ratio between the sizes of the two parties and the cultural influence. Few steps forward, toward more refined models, which include a digression on the kind of the felt experiences and some structure on the random interaction topology (as dilution to avoid the plain mean-field approach) and correlations of experiences felt between the two parties (biasing the distribution of the coupling) are discussed at the end, where we show the robustness of our approach.

  3. Pedagogic process modeling: Humanistic-integrative approach

    Directory of Open Access Journals (Sweden)

    Boritko Nikolaj M.

    2007-01-01

    Full Text Available The paper deals with some current problems of modeling the dynamics of the subject-features development of the individual. The term "process" is considered in the context of the humanistic-integrative approach, in which the principles of self education are regarded as criteria for efficient pedagogic activity. Four basic characteristics of the pedagogic process are pointed out: intentionality reflects logicality and regularity of the development of the process; discreteness (stageability in dicates qualitative stages through which the pedagogic phenomenon passes; nonlinearity explains the crisis character of pedagogic processes and reveals inner factors of self-development; situationality requires a selection of pedagogic conditions in accordance with the inner factors, which would enable steering the pedagogic process. Offered are two steps for singling out a particular stage and the algorithm for developing an integrative model for it. The suggested conclusions might be of use for further theoretic research, analyses of educational practices and for realistic predicting of pedagogical phenomena. .

  4. Quantum gravitation the Feynman path integral approach

    CERN Document Server

    Hamber, Herbert W

    2009-01-01

    The book covers the theory of Quantum Gravitation from the point of view of Feynman path integrals. These provide a manifestly covariant approach in which fundamental quantum aspects of the theory such as radiative corrections and the renormalization group can be systematically and consistently addressed. The path integral method is suitable for both perturbative as well as non-perturbative studies, and is known to already provide a framework of choice for the theoretical investigation of non-abelian gauge theories, the basis for three of the four known fundamental forces in nature. The book thus provides a coherent outline of the present status of the theory gravity based on Feynman’s formulation, with an emphasis on quantitative results. Topics are organized in such a way that the correspondence to similar methods and results in modern gauge theories becomes apparent. Covariant perturbation theory are developed using the full machinery of Feynman rules, gauge fixing, background methods and ghosts. The ren...

  5. Introduction to solid mechanics an integrated approach

    CERN Document Server

    Lubliner, Jacob

    2014-01-01

    This textbook presents for the first time in one text the concepts and processes covered in statics and mechanics of materials curricula following a systematic, topically integrated approach. Since the turn of the millennium, it has become common in engineering schools to combine the traditional undergraduate offerings in rigid-body statics (usually called “statics”) and deformable body mechanics (known traditionally as “strength of materials” or, more recently, “mechanics of materials”) into a single, introductory course in solid mechanics. Many textbooks for the new course sequentially meld pieces of existing, discrete books—sometimes, but not always, acknowledging the origin—into two halves covering Statics and Mechanics of Materials. In this volume, Professors Lubliner and Papadopoulos methodically combine the essentials of statics and mechanics of materials, illustrating the relationship of concepts throughout, into one "integrated" text. This book also: ·         Offers thorough...

  6. Integration models: multicultural and liberal approaches confronted

    Science.gov (United States)

    Janicki, Wojciech

    2012-01-01

    European societies have been shaped by their Christian past, upsurge of international migration, democratic rule and liberal tradition rooted in religious tolerance. Boosting globalization processes impose new challenges on European societies, striving to protect their diversity. This struggle is especially clearly visible in case of minorities trying to resist melting into mainstream culture. European countries' legal systems and cultural policies respond to these efforts in many ways. Respecting identity politics-driven group rights seems to be the most common approach, resulting in creation of a multicultural society. However, the outcome of respecting group rights may be remarkably contradictory to both individual rights growing out from liberal tradition, and to reinforced concept of integration of immigrants into host societies. The hereby paper discusses identity politics upturn in the context of both individual rights and integration of European societies.

  7. Hypergeometric Functions with Integral Parameter Differences

    DEFF Research Database (Denmark)

    Karlsson, Per W.

    1971-01-01

    For a generalized hypergeometric function pFq(z) with positive integral differences between certain numerator and denominator parameters, a formula expressing the pFq(z) as a finite sum of lower-order functions is proved. From this formula, Minton's two summation theorems for p = q + 1, z = 1...

  8. Integral transform techniques for Green's function

    CERN Document Server

    Watanabe, Kazumi

    2015-01-01

    This book describes mathematical techniques for integral transforms in a detailed but concise manner. The techniques are subsequently applied to the standard partial differential equations, such as the Laplace equation, the wave equation and elasticity equations. Green’s functions for beams, plates and acoustic media are also shown, along with their mathematical derivations. The Cagniard-de Hoop method for double inversion is described in detail, and 2D and 3D elastodynamic problems are treated in full. This new edition explains in detail how to introduce the branch cut for the multi-valued square root function. Further, an exact closed form Green’s function for torsional waves is presented, as well as an application technique of the complex integral, which includes the square root function and an application technique of the complex integral.

  9. A Symmetric Approach Elucidates Multisensory Information Integration

    Directory of Open Access Journals (Sweden)

    Arturo Tozzi

    2016-12-01

    Full Text Available Recent advances in neuronal multisensory integration suggest that the five senses do not exist in isolation of each other. Perception, cognition and action are integrated at very early levels of central processing, in a densely-coupled system equipped with multisensory interactions occurring at all temporal and spatial stages. In such a novel framework, a concept from the far-flung branch of topology, namely the Borsuk-Ulam theorem, comes into play. The theorem states that when two opposite points on a sphere are projected onto a circumference, they give rise to a single point containing their matching description. Here we show that the theorem applies also to multisensory integration: two environmental stimuli from different sensory modalities display similar features when mapped into cortical neurons. Topological tools not only shed new light on questions concerning the functional architecture of mind and the nature of mental states, but also provide an empirically assessable methodology. We argue that the Borsuk-Ulam theorem is a general principle underlying nervous multisensory integration, resulting in a framework that has the potential to be operationalized.

  10. Plasmonic properties of metal nanoislands: surface integral equations approach

    Science.gov (United States)

    Scherbak, S. A.; Lipovskii, A. A.

    2016-08-01

    The surface integral equations method is used to analyse the surface plasmon resonance position in a metal island film formed by non-interacting axisymmetrical prolate/oblate hemispheroids placed on a dielectric substrate. The approach is verified via the comparison of results obtained for a hemisphere on a substrate with the ones obtained using the multipole expansion method. The preference of the integral equations method is in obtaining a simple final analytical expression for a particle polarizability in which any dielectric function of a metal can be substituted. Such simple formulae for the hemispherical particle on the substrate and calculated dependences of the hemispheroid resonant wavelength on its aspect ratio are presented.

  11. Nonadditive Set Functions Defined by Aumann Fuzzy Integrals

    Institute of Scientific and Technical Information of China (English)

    刘彦奎; 刘宝碇

    2003-01-01

    A novel concept, called nonadditive set-valued measure, is first defined as a monotone and continuous set function. Then the interconnections between nonadditive set-valued measure and the additive set-valued measure as well as the fuzzy measure are discussed. Finally, an approach to construct a nonadditive compact set-valued measure is presented via Aumann fuzzy integral.

  12. Approach for Improving the Integrated Sensor Orientation

    Science.gov (United States)

    Mitishita, E.; Ercolin Filho, L.; Graça, N.; Centeno, J.

    2016-06-01

    The direct determination of exterior orientation parameters (EOP) of aerial images via integration of the Inertial Measurement Unit (IMU) and GPS is often used in photogrammetric mapping nowadays. The accuracies of the EOP depend on the accurate parameters related to sensors mounting when the job is performed (offsets of the IMU relative to the projection centre and the angles of boresigth misalignment between the IMU and the photogrammetric coordinate system). In principle, when the EOP values do not achieve the required accuracies for the photogrammetric application, the approach, known as Integrated Sensor Orientation (ISO), is used to refine the direct EOP. ISO approach requires accurate Interior Orientation Parameters (IOP) and standard deviation of the EOP under flight condition. This paper investigates the feasibility of use the in situ camera calibration to obtain these requirements. The camera calibration uses a small sub block of images, extracted from the entire block. A digital Vexcel UltraCam XP camera connected to APPLANIX POS AVTM system was used to get two small blocks of images that were use in this study. The blocks have different flight heights and opposite flight directions. The proposed methodology improved significantly the vertical and horizontal accuracies of the 3D point intersection. Using a minimum set of control points, the horizontal and vertical accuracies achieved nearly one image pixel of resolution on the ground (GSD). The experimental results are shown and discussed.

  13. APPROACH FOR IMPROVING THE INTEGRATED SENSOR ORIENTATION

    Directory of Open Access Journals (Sweden)

    E. Mitishita

    2016-06-01

    Full Text Available The direct determination of exterior orientation parameters (EOP of aerial images via integration of the Inertial Measurement Unit (IMU and GPS is often used in photogrammetric mapping nowadays. The accuracies of the EOP depend on the accurate parameters related to sensors mounting when the job is performed (offsets of the IMU relative to the projection centre and the angles of boresigth misalignment between the IMU and the photogrammetric coordinate system. In principle, when the EOP values do not achieve the required accuracies for the photogrammetric application, the approach, known as Integrated Sensor Orientation (ISO, is used to refine the direct EOP. ISO approach requires accurate Interior Orientation Parameters (IOP and standard deviation of the EOP under flight condition. This paper investigates the feasibility of use the in situ camera calibration to obtain these requirements. The camera calibration uses a small sub block of images, extracted from the entire block. A digital Vexcel UltraCam XP camera connected to APPLANIX POS AVTM system was used to get two small blocks of images that were use in this study. The blocks have different flight heights and opposite flight directions. The proposed methodology improved significantly the vertical and horizontal accuracies of the 3D point intersection. Using a minimum set of control points, the horizontal and vertical accuracies achieved nearly one image pixel of resolution on the ground (GSD. The experimental results are shown and discussed.

  14. 医院廉政文化:内涵、功能与实施路径%Hospital Integrity Culture:Connotation, Function and Implementation Approach

    Institute of Scientific and Technical Information of China (English)

    范春梅; 孔凡红

    2014-01-01

    医院是社会的特殊单元,以治疗疾病、促进健康的医学实践活动来履行其在社会中的社会职责和发展的。医院廉政文化是具有医疗行业特点的廉政价值观念和精神追求、医疗从业人员职业道德规范和廉洁从业的行为准则、诚信理念和为全社会廉政文化发展产生辐射影响等行业特质内涵,发挥着导向、规范、凝聚、辐射等功能。医院廉政文化既是一种理论,更是实实在在的实践,应做好与医德医风建设、“三好一满意”活动和廉政风险防控管理的有机结合,使廉政文化建设更具系统性,以廉政文化建设提升医院管理水平。%Hospital is a special unit of society, which fulfills its social responsibility and attains its development by medical practice and health promotion. The hospital integrity culture possesses its integrity value and spiritual pursuit with the characteristics of the medical industry, and connotation of medical staffs' professional ethics, code of conduct, honesty principle as well as radiation effects of integrity to the whole social development. It plays a role in guidance, criterion, coagulation and radiation. Hospital integrity culture is not only a theory but also a practice that should combine the construction of medical ethics,"three good and one satisfaction"activity and the work of integrity risk prevention and control administration in order to achieve a more systematical integrity cultural construction and improve the hospital administration level.

  15. Integration Over Connections in the Discretized Gravitational Functional Integrals

    Science.gov (United States)

    Khatsymovsky, V. M.

    The result of performing integrations over connection type variables in the path integral for the discrete field theory may be poorly defined in the case of non-compact gauge group with the Haar measure exponentially growing in some directions. This point is studied in the case of the discrete form of the first-order formulation of the Einstein gravity theory. Here the result of interest can be defined as generalized function (of the rest of variables of the type of tetrad or elementary areas), i.e. a functional on a set of probe functions. To define this functional, we calculate its values on the products of components of the area tensors, the so-called moments. The resulting distribution (in fact, probability distribution) has singular (δ-function-like) part with support in the nonphysical region of the complex plane of area tensors and regular part (usual function) which decays exponentially at large areas. As we discuss, this also provides suppression of large edge lengths which is important for internal consistency, if one asks whether gravity on short distances can be discrete. Some other features of the obtained probability distribution including occurrence of the local maxima at a number of the approximately equidistant values of area are also considered.

  16. Total Correlation Function Integrals and Isothermal Compressibilities from Molecular Simulations

    DEFF Research Database (Denmark)

    Wedberg, Rasmus; Peters, Günther H.j.; Abildskov, Jens

    2008-01-01

    Generation of thermodynamic data, here compressed liquid density and isothermal compressibility data, using molecular dynamics simulations is investigated. Five normal alkane systems are simulated at three different state points. We compare two main approaches to isothermal compressibilities: (1...... in approximately the same amount of time. This suggests that computation of total correlation function integrals is a route to isothermal compressibility, as accurate and fast as well-established benchmark techniques. A crucial step is the integration of the radial distribution function. To obtain sensible results...

  17. A path integral approach to asset-liability management

    Science.gov (United States)

    Decamps, Marc; De Schepper, Ann; Goovaerts, Marc

    2006-05-01

    Functional integrals constitute a powerful tool in the investigation of financial models. In the recent econophysics literature, this technique was successfully used for the pricing of a number of derivative securities. In the present contribution, we introduce this approach to the field of asset-liability management. We work with a representation of cash flows by means of a two-dimensional delta-function perturbation, in the case of a Brownian model and a geometric Brownian model. We derive closed-form solutions for a finite horizon ALM policy. The results are numerically and graphically illustrated.

  18. An Integrated Approach to Anti-Cancer Drug Sensitivity Prediction.

    Science.gov (United States)

    Berlow, Noah; Haider, Saad; Wan, Qian; Geltzeiler, Mathew; Davis, Lara E; Keller, Charles; Pal, Ranadip

    2014-01-01

    A framework for design of personalized cancer therapy requires the ability to predict the sensitivity of a tumor to anticancer drugs. The predictive modeling of tumor sensitivity to anti-cancer drugs has primarily focused on generating functions that map gene expressions and genetic mutation profiles to drug sensitivity. In this paper, we present a new approach for drug sensitivity prediction and combination therapy design based on integrated functional and genomic characterizations. The modeling approach when applied to data from the Cancer Cell Line Encyclopedia shows a significant gain in prediction accuracy as compared to elastic net and random forest techniques based on genomic characterizations. Utilizing a Mouse Embryonal Rhabdomyosarcoma cell culture and a drug screen of 60 targeted drugs, we show that predictive modeling based on functional data alone can also produce high accuracy predictions. The framework also allows us to generate personalized tumor proliferation circuits to gain further insights on the individualized biological pathway.

  19. Integrating systems Approaches into Pharmaceutical Sciences

    DEFF Research Database (Denmark)

    Westerhoff, H.V.; Mosekilde, Erik; Noe, C. R.

    2008-01-01

    of the conference was to promote the ‘Integration of Systems Approaches into Pharmaceutical Sciences’ in view of optimising the development of new effective drugs. And a challenge this is, considering both the high attrition rates in the pharmaceutical industry and the failure of finding definitive drug solutions......During the first week of December 2007, the European Federation for Pharmaceutical Sciences (EUFEPS) and BioSim, the major European Network of Excellence on Systems Biology, held a challenging conference on the use of mathematical models in the drug development process. More precisely, the purpose...... for many of the diseases that plague mankind today. The conference was co-sponsored by the American College of Clinical Pharmacology, the European Center for Pharmaceutical Medicine, and the Swiss Society of Pharmaceutical Sciences and, besides representatives from the European Regulatory Agencies and FDA...

  20. Stakeholder interaction within the ERICA Integrated Approach

    Energy Technology Data Exchange (ETDEWEB)

    Zinger, I. [Swedish Radiation Protection Authority, 171 16 Stockholm (Sweden)], E-mail: irene@facilia.se; Oughton, D.H. [Norwegian University of Life Sciences, Department of Plant and Environmental Sciences, PO Box 5003, 1432 As (Norway); Jones, S.R. [Westlakes Scientific Consulting Ltd., Westlakes Research Institute/Westlakes Scientific Consulting, Westlakes Science Park Moor Row, Cumbria CA24 3LN (United Kingdom)

    2008-09-15

    Within the ERICA project, stakeholder involvement has been addressed within three main areas: generic interactions throughout the project, specific consultation by means of attendance to events and considerations as part of the ERICA Integrated Approach and Assessment Tool. The word stakeholders meant namely any individual or group who may be affected by or have an interest in an issue, and to include experts, lay-people and the public. An End-Users-Group (EUG) was set up to facilitate the two-way dialogue between the ERICA Consortium and stakeholders. The ERICA EUG consisted of representatives of 60 organisations ranging from regulatory bodies, national advisory bodies, academia, non-governmental organisations, industry, consultants and inter-governmental organisations. Stakeholder interaction was included from the very start of the project. Inputs from the EUG were recorded and in most instances incorporated within the development of the project and thus influenced and helped to shape some of the ERICA deliverables.

  1. Permutation statistical methods an integrated approach

    CERN Document Server

    Berry, Kenneth J; Johnston, Janis E

    2016-01-01

    This research monograph provides a synthesis of a number of statistical tests and measures, which, at first consideration, appear disjoint and unrelated. Numerous comparisons of permutation and classical statistical methods are presented, and the two methods are compared via probability values and, where appropriate, measures of effect size. Permutation statistical methods, compared to classical statistical methods, do not rely on theoretical distributions, avoid the usual assumptions of normality and homogeneity of variance, and depend only on the data at hand. This text takes a unique approach to explaining statistics by integrating a large variety of statistical methods, and establishing the rigor of a topic that to many may seem to be a nascent field in statistics. This topic is new in that it took modern computing power to make permutation methods available to people working in the mainstream of research. This research monograph addresses a statistically-informed audience, and can also easily serve as a ...

  2. Thermodynamics and statistical mechanics an integrated approach

    CERN Document Server

    Shell, M Scott

    2015-01-01

    Learn classical thermodynamics alongside statistical mechanics with this fresh approach to the subjects. Molecular and macroscopic principles are explained in an integrated, side-by-side manner to give students a deep, intuitive understanding of thermodynamics and equip them to tackle future research topics that focus on the nanoscale. Entropy is introduced from the get-go, providing a clear explanation of how the classical laws connect to the molecular principles, and closing the gap between the atomic world and thermodynamics. Notation is streamlined throughout, with a focus on general concepts and simple models, for building basic physical intuition and gaining confidence in problem analysis and model development. Well over 400 guided end-of-chapter problems are included, addressing conceptual, fundamental, and applied skill sets. Numerous worked examples are also provided together with handy shaded boxes to emphasize key concepts, making this the complete teaching package for students in chemical engineer...

  3. Systematic Approach to Better Understanding Integration Costs

    Energy Technology Data Exchange (ETDEWEB)

    Stark, Gregory B. [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2015-09-01

    This research presents a systematic approach to evaluating the costs of integrating new generation and operational procedures into an existing power system, and the methodology is independent of the type of change or nature of the generation. The work was commissioned by the U.S. Department of Energy and performed by the National Renewable Energy Laboratory to investigate three integration cost-related questions: (1) How does the addition of new generation affect a system's operational costs, (2) How do generation mix and operating parameters and procedures affect costs, and (3) How does the amount of variable generation (non-dispatchable wind and solar) impact the accuracy of natural gas orders? A detailed operational analysis was performed for seven sets of experiments: variable generation, large conventional generation, generation mix, gas prices, fast-start generation, self-scheduling, and gas supply constraints. For each experiment, four components of integration costs were examined: cycling costs, non-cycling VO&M costs, fuel costs, and reserves provisioning costs. The investigation was conducted with PLEXOS production cost modeling software utilizing an updated version of the Institute of Electrical and Electronics Engineers 118-bus test system overlaid with projected operating loads from the Western Electricity Coordinating Council for the Sacramento Municipal Utility District, Puget Sound Energy, and Public Service Colorado in the year 2020. The test system was selected in consultation with an industry-based technical review committee to be a reasonable approximation of an interconnection yet small enough to allow the research team to investigate a large number of scenarios and sensitivity combinations. The research should prove useful to market designers, regulators, utilities, and others who want to better understand how system changes can affect production costs.

  4. A Feynman integral via higher normal functions

    CERN Document Server

    Bloch, Spencer; Vanhove, Pierre

    2014-01-01

    We study the Feynman integral for the three-banana graph defined as the scalar two-point self-energy at three-loop order. The Feynman integral is evaluated for all identical internal masses in two space-time dimensions. Two calculations are given for the Feynman integral; one based on an interpretation of the integral as an inhomogeneous solution of a classical Picard-Fuchs differential equation, and the other using arithmetic algebraic geometry, motivic cohomology, and Eisenstein series. Both methods use the rather special fact that the Feynman integral is a family of regulator periods associated to a family of K3 surfaces. We show that the integral is given by a sum of elliptic trilogarithms evaluated at sixth roots of unity. This elliptic trilogarithm value is related to the regulator of a class in the motivic cohomology of the K3 family. We prove a conjecture by David Broadhurst that at a special kinematical point the Feynman integral is given by a critical value of the Hasse-Weil L-function of the K3 sur...

  5. Integrating Retinoic Acid Signaling with Brain Function

    Science.gov (United States)

    Luo, Tuanlian; Wagner, Elisabeth; Drager, Ursula C.

    2009-01-01

    The vitamin A derivative retinoic acid (RA) regulates the transcription of about a 6th of the human genome. Compelling evidence indicates a role of RA in cognitive activities, but its integration with the molecular mechanisms of higher brain functions is not known. Here we describe the properties of RA signaling in the mouse, which point to…

  6. Teaching psychodynamic psychotherapy to psychiatric residents: an integrated approach.

    Science.gov (United States)

    Gastelum, Emily; Douglas, Carolyn J; Cabaniss, Deborah L

    2013-03-01

    There is enduring controversy in our field regarding the place for supportive interventions in psychodynamic psychotherapy. This controversy is reflected in the differing ways in which psychodynamic psychotherapy has been conceptualized and taught in psychiatric residency training programs. The authors propose an "integrated" approach for teaching psychodynamic psychotherapy to trainees. In the integrated model, psychodynamic psychotherapy is conceptualized as a form of therapy designed to (a) uncover unconscious elements that influence thoughts, feelings, and behavior, and (b) support weakened psychological function. Using this model, residents learning psychodynamic psychotherapy are taught both uncovering and supporting techniques side by side in one course with specific guidelines for assessing when to use one set of interventions or the other. Teaching psychodynamic psychotherapy to residents in this integrated way prepares them to become skilled clinicians who are able to move fluidly from supporting to uncovering in a pragmatic and flexible manner, matched to the particular moment-to-moment needs of the individual patient.

  7. Approaches to Pendent Groups' Functionalization of Polyimide

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    Pendent groups' functionalization of polyimide is an optimum approach to improve its processability and achieve functionalized polyimide materials. There are two types of modification routes for pendent groups functionalization of polyimide: monomer route and macromolecular route. In this paper, various approaches for pendent groups' functionalization of polyimide are introduced. At the same time, a new method to achieve functional polyimide materials without decreasing its thermal stability and mechanical properties is mentioned.

  8. Age Classification Based On Integrated Approach

    Directory of Open Access Journals (Sweden)

    Pullela. SVVSR Kumar

    2014-05-01

    Full Text Available The present paper presents a new age classification method by integrating the features derived from Grey Level Co-occurrence Matrix (GLCM with a new structural approach derived from four distinct LBP's (4-DLBP on a 3 x 3 image. The present paper derived four distinct patterns called Left Diagonal (LD, Right diagonal (RD, vertical centre (VC and horizontal centre (HC LBP's. For all the LBP's the central pixel value of the 3 x 3 neighbourhood is significant. That is the reason in the present research LBP values are evaluated by comparing all 9 pixels of the 3 x 3 neighbourhood with the average value of the neighbourhood. The four distinct LBP's are grouped into two distinct LBP's. Based on these two distinct LBP's GLCM is computed and features are evaluated to classify the human age into four age groups i.e: Child (0-15, Young adult (16-30, Middle aged adult (31-50 and senior adult (>50. The co-occurrence features extracted from the 4-DLBP provides complete texture information about an image which is useful for classification. The proposed 4-DLBP reduces the size of the LBP from 6561 to 79 in the case of original texture spectrum and 2020 to 79 in the case of Fuzzy Texture approach.

  9. Pressure Shell Approach to Integrated Environmental Protection

    Science.gov (United States)

    Kennedy, Kriss J.

    2011-01-01

    The next generation of exploration mission human systems will require environmental protection such as radiation protection that is effective and efficient. In order to continue human exploration, habitat systems will require special shells to protect astronauts from hostile environments. The Pressure Shell Approach to integrated environmental (radiation) protection is a multi-layer shell that can be used for multifunctional environmental protection. Self-healing, self-repairing nano technologies and sensors are incorporated into the shell. This shell consists of multiple layers that can be tailored for specific environmental protection needs. Mainly, this innovation focuses on protecting crew from exposure to micrometeorites, thermal, solar flares, and galactic cosmic ray (GCR) radiation. The Pressure Shell Approach consists of a micrometeoroid and secondary ejecta protection layer; a thin, composite shell placed in between two layers that is non-structural; an open cavity layer that can be filled with water, regolith, or polyethylene foam; a thicker composite shell that is a structural load bearing that is placed between two layers; and a bladder coating on the interior composite shell. This multi-layer shell creates an effective radiation protection system. Most of its layers can be designed with the materials necessary for specific environments. In situ materials such as water or regolith can be added to the shell design for supplemental radiation protection.

  10. Integrated microsystems packaging approach with LCP

    Science.gov (United States)

    Jaynes, Paul; Shacklette, Lawrence W.

    2006-05-01

    Within the government communication market there is an increasing push to further miniaturize systems with the use of chip-scale packages, flip-chip bonding, and other advances over traditional packaging techniques. Harris' approach to miniaturization includes these traditional packaging advances, but goes beyond this level of miniaturization by combining the functional and structural elements of a system, thus creating a Multi-Functional Structural Circuit (MFSC). An emerging high-frequency, near hermetic, thermoplastic electronic substrate material, Liquid Crystal Polymer (LCP), is the material that will enable the combination of the electronic circuit and the physical structure of the system. The first embodiment of this vision for Harris is the development of a battlefield acoustic sensor module. This paper will introduce LCP and its advantages for MFSC, present an example of the work that Harris has performed, and speak to LCP MFSCs' potential benefits to miniature communications modules and sensor platforms.

  11. Diagnostic Approach to Functional Recovery

    DEFF Research Database (Denmark)

    Havsteen, Inger; Madsen, Kristoffer H; Christensen, Hanne Krarup

    2013-01-01

    a substantial capacity to reorganize after a focal ischemic (or hemorrhagic) brain lesion. This functional reorganization contributes to functional recovery after stroke. Functional magnetic resonance imaging (fMRI) provides a valuable tool to capture the spatial and temporal activity changes in response......, only up to 20-25% of patients are eligible to causal treatment. Further, care in a specialized stroke unit improves prognosis in all patients independent of age and stroke severity. Even when it is not possible to prevent tissue loss, the surviving brain areas of functional brain networks have...... to an acute ischemic lesion. Task-related as well as resting-state fMRI have been successfully applied to elucidate post-stroke remodeling of functional brain networks. This includes regional changes in neuronal activation as well as distributed changes in functional brain connectivity. Since fMRI is readily...

  12. Symbolic Tensor Calculus -- Functional and Dynamic Approach

    CERN Document Server

    Woszczyna, A; Czaja, W; Golda, Z A

    2016-01-01

    In this paper, we briefly discuss the dynamic and functional approach to computer symbolic tensor analysis. The ccgrg package for Wolfram Language/Mathematica is used to illustrate this approach. Some examples of applications are attached.

  13. A Path Integral Approach to Inclusive Processes

    CERN Document Server

    Nachtmann, O

    2000-01-01

    The single-particle inclusive differential cross-section for a reaction$a+b\\to c+X$ is written as the imaginary part of a correlation function in afor ward scattering amplitude for $a+b\\to a+b$ in a modified effective theory.In this modified theory the interaction Hamiltonian $\\tilde H_I$ equals $H_I$in the original theory up to a certain time. Then there is a sign change and$\\tilde H_I$ becomes nonlocal. This is worked out in detail for scalar fieldmodels and for QED plus the abelian gluon model. A suitable path integral fordirect calculations of inclusive cross sections is presented.

  14. An Integrated Approach to Crop Genetic Improvement

    Institute of Scientific and Technical Information of China (English)

    Martin A. J. Parry; Malcolm J. Hawkesford

    2012-01-01

    The balance between the supply and demand of the major food crops is fragile,fueling concerns for long-term global food security.The rising population,increasing wealth and a proliferation of nonfood uses (e.g.bioenergy) has led to growing demands on agriculture,while increased production is limited by greater urbanization,and the degradation of land.Furthermore,global climate change with increasing temperatures and lower,more erratic rainfall is projected to decrease agricultural yields.There is a predicted need to increase food production by at least 70% by 2050 and therefore an urgent need to develop novel and integrated approaches,incorporating high-throughput phenotyping that will both increase production per unit area and simultaneously improve the resource use efficiency of crops.Yield potential,yield stability,nutrient and water use are all complex multigenic traits and while there is genetic variability,their complexity makes such traits difficult to breed for directly.Nevertheless molecular plant breeding has the potential to deliver substantial improvements,once the component traits and the genes underlying these traits have been identified.In addition,interactions between the individual traits must also be taken into account,a demand that is difficult to fulfill with traditional screening approaches.Identified traits will be incorporated into new cultivars using conventional or biotechnological tools.In order to better understand the relationship between genotype,component traits,and environment over time,a multidisciplinary approach must be adopted to both understand the underlying processes and identify candidate genes,QTLs and traits that can be used to develop improved crops.

  15. Integrated plant information technology design support functionality

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Yeon Seung; Kim, Dae Jin [Korea Atomic Energy Research Institute, Taejon (Korea, Republic of); Barber, P. W.; Goland, D. [Atomic Energy Canada Ltd., (Canada)

    1996-06-01

    This technical report was written as a result of Integrated Plant Information System (IPIS) feasibility study on CANDU 9 project which had been carried out from January, 1994 to March, 1994 at AECL (Atomic Energy Canada Limited) in Canada. From 1987, AECL had done endeavour to change engineering work process from paper based work process to computer based work process through CANDU 3 project. Even though AECL had a lot of good results form computerizing the Process Engineering, Instrumentation Control and Electrical Engineering, Mechanical Engineering, Computer Aided Design and Drafting, and Document Management System, but there remains the problem of information isolation and integration. On this feasibility study, IPIS design support functionality guideline was suggested by evaluating current AECL CAE tools, analyzing computer aided engineering task and work flow, investigating request for implementing integrated computer aided engineering and describing Korean request for future CANDU design including CANDU 9. 6 figs. (Author).

  16. On-line optical and X-ray spectroscopies with crystallography: an integrated approach for determining metalloprotein structures in functionally well defined states.

    Science.gov (United States)

    Ellis, Mark J; Buffey, Steven G; Hough, Michael A; Hasnain, S Samar

    2008-09-01

    X-ray-induced redox changes can lead to incorrect assignments of the functional states of metals in metalloprotein crystals. The need for on-line monitoring of the status of metal ions (and other chromophores) during protein crystallography experiments is of growing importance with the use of intense synchrotron X-ray beams. Significant efforts are therefore being made worldwide to combine different spectroscopies in parallel with X-ray crystallographic data collection. Here the implementation and utilization of optical and X-ray absorption spectroscopies on the modern macromolecular crystallography (MX) beamline 10, at the SRS, Daresbury Laboratory, is described. This beamline is equipped with a dedicated monolithic energy-dispersive X-ray fluorescence detector, allowing X-ray absorption spectroscopy (XAS) measurements to be made in situ on the same crystal used to record the diffraction data. In addition, an optical microspectrophotometer has been incorporated on the beamline, thus facilitating combined MX, XAS and optical spectroscopic measurements. By uniting these techniques it is also possible to monitor the status of optically active and optically silent metal centres present in a crystal at the same time. This unique capability has been applied to observe the results of crystallographic data collection on crystals of nitrite reductase from Alcaligenes xylosoxidans, which contains both type-1 and type-2 Cu centres. It is found that the type-1 Cu centre photoreduces quickly, resulting in the loss of the 595 nm peak in the optical spectrum, while the type-2 Cu centre remains in the oxidized state over a much longer time period, for which independent confirmation is provided by XAS data as this centre has an optical spectrum which is barely detectable using microspectrophotometry. This example clearly demonstrates the importance of using two on-line methods, spectroscopy and XAS, for identifying well defined redox states of metalloproteins during

  17. Integration of macromolecular diffraction data using radial basis function networks.

    Science.gov (United States)

    Pokrić, B; Allinson, N M; Helliwell, J R

    2000-11-01

    This paper presents a novel approach for intensity calculation of X-ray diffraction spots based on a two-stage radial basis function (RBF) network. The first stage uses pre-determined reference profiles from a database as basis functions in order to locate the diffraction spots and identify any overlapping regions. The second-stage RBF network employs narrow basis functions capable of local modifications of the reference profiles leading to a more accurate observed diffraction spot approximation and therefore accurate determination of spot positions and integrated intensities.

  18. Integrals of products of Hurwitz zeta functions

    CERN Document Server

    Shpot, M A; Paris, R B

    2016-01-01

    We evaluate two integrals over $x\\in [0,1]$ involving products of the function $\\zeta_1(a,x)\\equiv \\zeta(a,x)-x^{-a}$ for $\\Re (a)>1$, where $\\zeta(a,x)$ is the Hurwitz zeta function. The evaluation of these integrals for the particular case of integer $a\\geq 2$ is also presented. As an application we calculate the $O(g)$ weak-coupling expansion coefficient $c_{1}(\\varepsilon)$ of the Casimir energy for a film with Dirichlet-Dirichlet boundary conditions, first stated by Symanzik [Schr\\"odinger representation and Casimir effect in renormalizable quantum field theory, Nucl. Phys. B 190 (1981) 1-44] in the framework of $g\\phi^4_{4-\\varepsilon}$ theory.

  19. Integrative and Interdisciplinary Approaches to Leadership Development.

    Science.gov (United States)

    Owen, Julie E

    2015-01-01

    Integrating diverse conceptions of leadership across different disciplines, perspectives, and epistemologies is imperative if leaders are to operate in a global and networked world. Interdisciplinary and integrative leadership courses and digital learning communities are featured examples.

  20. An integrative approach to understanding bird origins.

    Science.gov (United States)

    Xu, Xing; Zhou, Zhonghe; Dudley, Robert; Mackem, Susan; Chuong, Cheng-Ming; Erickson, Gregory M; Varricchio, David J

    2014-12-12

    Recent discoveries of spectacular dinosaur fossils overwhelmingly support the hypothesis that birds are descended from maniraptoran theropod dinosaurs, and furthermore, demonstrate that distinctive bird characteristics such as feathers, flight, endothermic physiology, unique strategies for reproduction and growth, and a novel pulmonary system originated among Mesozoic terrestrial dinosaurs. The transition from ground-living to flight-capable theropod dinosaurs now probably represents one of the best-documented major evolutionary transitions in life history. Recent studies in developmental biology and other disciplines provide additional insights into how bird characteristics originated and evolved. The iconic features of extant birds for the most part evolved in a gradual and stepwise fashion throughout archosaur evolution. However, new data also highlight occasional bursts of morphological novelty at certain stages particularly close to the origin of birds and an unavoidable complex, mosaic evolutionary distribution of major bird characteristics on the theropod tree. Research into bird origins provides a premier example of how paleontological and neontological data can interact to reveal the complexity of major innovations, to answer key evolutionary questions, and to lead to new research directions. A better understanding of bird origins requires multifaceted and integrative approaches, yet fossils necessarily provide the final test of any evolutionary model.

  1. Integral transform techniques for Green's function

    CERN Document Server

    Watanabe, Kazumi

    2014-01-01

    In this book mathematical techniques for integral transforms are described in detail but concisely. The techniques are applied to the standard partial differential equations, such as the Laplace equation, the wave equation and elasticity equations. The Green's functions for beams, plates and acoustic media are also shown along with their mathematical derivations. Lists of Green's functions are presented for the future use. The Cagniard's-de Hoop method for the double inversion is described in detail, and 2D and 3D elasto-dynamics problems are fully treated.

  2. An integral involving the generalized zeta function

    Directory of Open Access Journals (Sweden)

    E. Elizalde

    1990-01-01

    Full Text Available A general value for ∫abdtlogΓ(t, for a, b positive reals, is derived in terms of the Hurwitz ζ function. That expression is checked for a previously known special integral, and the case where a is a positive integer and b is half an odd integer is considered. The result finds application in calculating the numerical value of the derivative of the Riemann zeta function at the point −1, a quantity that arises in the evaluation of determinants of Laplacians on compact Riemann surfaces.

  3. Safety in Schools: An Integral Approach

    Science.gov (United States)

    Gairin, Joaquin; Castro, Diego

    2011-01-01

    The present paper summarizes a research project into integral safety in schools. The aims of this particular research are, firstly, to evaluate the degree of integral safety in schools, secondly, to propose means for improving prevention and integral safety systems and thirdly, to identify the characteristics of safety culture. The field work was…

  4. Silicon Photodetectors Matrix Coordinate Bipolar Functionally Integrated Structures

    Directory of Open Access Journals (Sweden)

    V.N. Murashev

    2015-03-01

    Full Text Available In this paper a new approach for solving the detection and coordinate the detection of radiation in the optical range of 0.3-1.1 microns, based on the use of so-called bipolar functionally integrated structures (BI-FIS in pixels photodetector arrays is discussed. Variants of new technical solutions based on photo-detectors matrix pixel BI-FIS structures are shown. Their effectiveness and scope are evaluated.

  5. Integrating lifestyle approaches into osteoarthritis care

    Directory of Open Access Journals (Sweden)

    Garver MJ

    2015-09-01

    Full Text Available Matthew J Garver,1 Brian C Focht,2 Sarah J Taylor3 1Department of Kinesiology and Nutrition, Abilene Christian University, Abilene, TX, 2Department of Human Sciences, Ohio State University, Columbus, OH, 3School of Occupational Therapy, Texas Woman's University, Dallas, TX, USA Abstract: As the lifetime risk, societal cost, and overall functional impact of osteoarthritis (OA is imposing, it is imperative that clinicians provide an individualized care model for patients. Patients must be offered a multiplicity of care strategies and encouraged to embrace lifestyle approaches for self-managing the effects and symptoms of OA. Certainly, the attitude of the clinician and patient will directly influence receptivity and implementation of lifestyle approaches. This work proposes how the use of structured and routine assessments and cognitive therapy ideologies may complement a comprehensive treatment plan. Assessments described herein include objective and/or self-report measures of physical function, pain, attitude about social support, and sleep quality. Baseline assessments followed by systematic monitoring of the results may give patients and clinicians valuable insight into the effectiveness of the care plan. Empirical evidence from randomized trials with OA patients highlights the effectiveness of cognitive behavioral change strategies for addressing salient concerns for OA (pain control, mobility performance, and sleep quality. Cognitive restructuring can provide patients with renewed power in managing their disease. Cognitive therapy topics discussed presently include: 1 what is OA?, 2 effectiveness of exercise and FITT (frequency, intensity, time, and type principles for OA patients, 3 goal-setting and barriers, and 4 translating to independent care. Woven within the discussion about cognitive therapy are ideas about how the results from baseline assessments and group-mediated dynamics might assist more favorable outcomes. There are a plethora

  6. An Integrated Computer-Aided Approach for Environmental Studies

    DEFF Research Database (Denmark)

    Gani, Rafiqul; Chen, Fei; Jaksland, Cecilia;

    1997-01-01

    A general framework for an integrated computer-aided approach to solve process design, control, and environmental problems simultaneously is presented. Physicochemical properties and their relationships to the molecular structure play an important role in the proposed integrated approach. The scope...... and applicability of the integrated approach is highlighted through examples involving estimation of properties and environmental pollution prevention. The importance of mixture effects on some environmentally important properties is also demonstrated....

  7. Single Robot Localisation Approach for Indoor Robotic Systems through Integration of Odometry and Artificial Landmarks

    OpenAIRE

    Ņikitenko, A; Liekna, A; Ekmanis, M.; Kuļikovskis, G; Andersone, I

    2013-01-01

    we present an integrated approach for robot localization that allows to integrate for the artificial landmark localization data with odometric sensors and signal transfer function data to provide means for different practical application scenarios. The sensor data fusion deals with asynchronous sensor data using inverse Laplace transform. We demonstrate a simulation software system that ensures smooth integration of the odometry-based and signal transfer – based localization into one approach.

  8. The function of consciousness in multisensory integration.

    Science.gov (United States)

    Palmer, Terry D; Ramsey, Ashley K

    2012-12-01

    The function of consciousness was explored in two contexts of audio-visual speech, cross-modal visual attention guidance and McGurk cross-modal integration. Experiments 1, 2, and 3 utilized a novel cueing paradigm in which two different flash suppressed lip-streams cooccured with speech sounds matching one of these streams. A visual target was then presented at either the audio-visually congruent or incongruent location. Target recognition differed for the congruent versus incongruent trials, and the nature of this difference depended on the probabilities of a target appearing at these respective locations. Thus, even though the lip-streams were never consciously perceived, they were nevertheless meaningfully integrated with the consciously perceived sounds, and participants learned to guide their attention according to statistical regularities between targets and these unconsciously perceived cross-modal cues. In Experiment 4, McGurk stimuli were presented in which the lip-streams were either flash suppressed (4a) or unsuppressed (4b), and the McGurk effect was found to vanish under conditions of flash suppression. Overall, these results suggest a simple yet fundamental principle regarding the function of consciousness in multisensory integration - cross-modal effects can occur in the absence of consciousness, but the influencing modality must be consciously perceived for its information to cross modalities.

  9. The functional integral formulation of the Schrieffer-Wolff transformation

    Science.gov (United States)

    Zamani, Farzaneh; Ribeiro, Pedro; Kirchner, Stefan

    2016-06-01

    We revisit the Schrieffer-Wolff transformation and present a path integral version of this important canonical transformation. The equivalence between the low-energy sector of the Anderson model in the so-called local moment regime and the spin-isotropic Kondo model is usually established via a canonical transformation performed on the Hamiltonian, followed by a projection. Here we present a path integral formulation of the Schrieffer-Wolff transformation which relates the functional integral form of the partition function of the Anderson model to that of its effective low-energy model. The resulting functional integral assumes the form of a spin path integral and includes a geometric phase factor, i.e. a Berry phase. Our approach stresses the underlying symmetries of the model and allows for a straightforward generalization of the transformation to more involved models. It thus not only sheds new light on a classic problem, it also offers a systematic route of obtaining effective low-energy models and higher order corrections. This is demonstrated by obtaining the effective low-energy model of a quantum dot attached to two ferromagnetic leads.

  10. A partial ordering approach for functional diversity.

    Science.gov (United States)

    Ricotta, Carlo; Szeidl, Laszlo; Moretti, Marco; Blasi, Carlo

    2011-09-01

    Functional diversity is generally regarded as the constituent of biological diversity that considers how the species functional traits affect ecosystem processes. Due to its ecological relevance, a number of indices of functional diversity have been proposed to date based on distinct objectives and motivations. Such proliferation of indices can be at least partially overcome by a more fundamental mathematical approach. In this paper we propose an intrinsic ordering approach for abundance-weighted measures of functional diversity that is similar to the Lorenz curves used by ecologists for ordering evenness measures. We then discuss the relevance of a number of functional diversity indices that have a behavior compatible with the proposed partial ordering.

  11. Integrated optics approach for advanced semiconductor lasers

    Science.gov (United States)

    Suematsu, Yasuharu; Arai, Shigehisa

    1987-11-01

    Recent advances in the field of semiconductor integrated optics are reviewed from the point of view of monolithic integration of semiconductor lasers and other optical components and/or devices. Emphasis is placed on dynamic-single-mode (DSM) lasers, such as DFB and DBR lasers, intended for highly stable single-wavelength light sources for such monolithic integration. The realization of high-performance DSM lasers and the fabrication techniques of monolithically integrated optical devices and circuits are briefly reviewed. A variety of potential applications is discussed.

  12. Lectures on functional analysis and the Lebesgue integral

    CERN Document Server

    Komornik, Vilmos

    2016-01-01

    This textbook, based on three series of lectures held by the author at the University of Strasbourg, presents functional analysis in a non-traditional way by generalizing elementary theorems of plane geometry to spaces of arbitrary dimension. This approach leads naturally to the basic notions and theorems. Most results are illustrated by the small ℓp spaces. The Lebesgue integral, meanwhile, is treated via the direct approach of Frigyes Riesz, whose constructive definition of measurable functions leads to optimal, clear-cut versions of the classical theorems of Fubini-Tonelli and Radon-Nikodým. Lectures on Functional Analysis and the Lebesgue Integral presents the most important topics for students, with short, elegant proofs. The exposition style follows the Hungarian mathematical tradition of Paul Erdős and others. The order of the first two parts, functional analysis and the Lebesgue integral, may be reversed. In the third and final part they are combined to study various spaces of continuous and integ...

  13. New approach to folding with the Coulomb wave function

    Energy Technology Data Exchange (ETDEWEB)

    Blokhintsev, L. D.; Savin, D. A. [Skobeltsyn Institute of Nuclear Physics, Lomonosov Moscow State University, Moscow 119991 (Russian Federation); Kadyrov, A. S. [Department of Physics, Astronomy and Medical Radiation Sciences, Curtin University, GPO Box U1987, Perth 6845 (Australia); Mukhamedzhanov, A. M. [Cyclotron Institute, Texas A and M University, College Station, Texas 77843 (United States)

    2015-05-15

    Due to the long-range character of the Coulomb interaction theoretical description of low-energy nuclear reactions with charged particles still remains a formidable task. One way of dealing with the problem in an integral-equation approach is to employ a screened Coulomb potential. A general approach without screening requires folding of kernels of the integral equations with the Coulomb wave. A new method of folding a function with the Coulomb partial waves is presented. The partial-wave Coulomb function both in the configuration and momentum representations is written in the form of separable series. Each term of the series is represented as a product of a factor depending only on the Coulomb parameter and a function depending on the spatial variable in the configuration space and the momentum variable if the momentum representation is used. Using a trial function, the method is demonstrated to be efficient and reliable.

  14. RISK MANAGEMENT: AN INTEGRATED APPROACH TO RISK MANAGEMENT AND ASSESSMENT

    Directory of Open Access Journals (Sweden)

    Szabo Alina

    2012-12-01

    Full Text Available Purpose: The objective of this paper is to offer an overview over risk management cycle by focusing on prioritization and treatment, in order to ensure an integrated approach to risk management and assessment, and establish the ‘top 8-12’ risks report within the organization. The interface with Internal Audit is ensured by the implementation of the scoring method to prioritize risks collected from previous generated risk report. Methodology/approach: Using evidence from other research in the area and the professional expertise, this article outlines an integrated approach to risk assessment and risk management reporting processes, by separating the risk in two main categories: strategic and operational risks. The focus is on risk prioritization and scoring; the final output will comprise a mix of strategic and operational (‘top 8-12’ risks, which should be used to establish the annual Internal Audit plan. Originality/value: By using an integrated approach to risk assessment and risk management will eliminate the need for a separate Internal Audit risk assessment over prevailing risks. It will reduce the level of risk assessment overlap by different functions (Tax, Treasury, Information System over the same risk categories as a single methodology, is used and will align timings of risk assessment exercises. The risk prioritization by usage of risk and control scoring criteria highlights the combination between financial and non-financial impact criteria allowing risks that do not naturally lend themselves to a financial amount to be also assessed consistently. It is emphasized the usage of score method to prioritize the risks included in the annual audit plan in order to increase accuracy and timelines.

  15. Integrating cell biology and proteomic approaches in plants.

    Science.gov (United States)

    Takáč, Tomáš; Šamajová, Olga; Šamaj, Jozef

    2017-04-22

    representative studies combining proteomic and cell biology methods for various purposes. Integrating cell biology approaches with proteomic ones allow validation and better interpretation of proteomic data. Moreover, cell biology methods remarkably extend the knowledge provided by proteomic studies and might be fundamental for the functional complementation of proteomic data. This review article summarizes current literature linking proteomics with cell biology. Copyright © 2017 Elsevier B.V. All rights reserved.

  16. Advanced multiresponse process optimisation an intelligent and integrated approach

    CERN Document Server

    Šibalija, Tatjana V

    2016-01-01

    This book presents an intelligent, integrated, problem-independent method for multiresponse process optimization. In contrast to traditional approaches, the idea of this method is to provide a unique model for the optimization of various processes, without imposition of assumptions relating to the type of process, the type and number of process parameters and responses, or interdependences among them. The presented method for experimental design of processes with multiple correlated responses is composed of three modules: an expert system that selects the experimental plan based on the orthogonal arrays; the factor effects approach, which performs processing of experimental data based on Taguchi’s quality loss function and multivariate statistical methods; and process modeling and optimization based on artificial neural networks and metaheuristic optimization algorithms. The implementation is demonstrated using four case studies relating to high-tech industries and advanced, non-conventional processes.

  17. Accelerating functional verification of an integrated circuit

    Energy Technology Data Exchange (ETDEWEB)

    Deindl, Michael; Ruedinger, Jeffrey Joseph; Zoellin, Christian G.

    2015-10-27

    Illustrative embodiments include a method, system, and computer program product for accelerating functional verification in simulation testing of an integrated circuit (IC). Using a processor and a memory, a serial operation is replaced with a direct register access operation, wherein the serial operation is configured to perform bit shifting operation using a register in a simulation of the IC. The serial operation is blocked from manipulating the register in the simulation of the IC. Using the register in the simulation of the IC, the direct register access operation is performed in place of the serial operation.

  18. Integrating Building Functions into Massive External Walls

    Directory of Open Access Journals (Sweden)

    Ahmed Hisham Hafez

    2016-05-01

    Full Text Available Well into the twentieth century, brick and stone were the materials used. Bricklaying and stonemasonry were the construction technologies employed for the exterior walls of virtually all major structures. However, with the rise in quality of life, the massive walls alone became incapable of fulfilling all the developed needs. Adjacent systems and layers had then to be attached to the massive layer. Nowadays, the external wall is usually composed of a layered construction. Each external wall function is usually represented by a separate layer or system. The massive layer of the wall is usually responsible for the load-bearing function.Traditional massive external walls vary in terms of their external appearance, their composition and attached layers. However, their design and construction process is usually a repeated process. It is a linear process where each discipline is concerned with a separate layer or system. These disciplines usually take their tasks away and bring them back to be re-integrated in a layered manner. New massive technologies with additional function have recently become available.Such technologies can provide the external wall with other functions in addition to its load-bearing function. The purpose of this research is to map the changes required to the traditional design and construction process when massive technologies with additional function are applied in external walls. Moreover, the research aims at assessing the performance of massive solutions with additional function when compared to traditional solutions in two different contexts, the Netherlands and Egypt.Through the analysis of different additional function technologies in external walls, a guidance scheme for different stakeholders is generated. It shows the expected process changes as related to the product level and customization level. Moreover, the research concludes that the performance of additional insulating technologies, and specifically Autoclaved

  19. A streamlined approach for pipeline integrity management

    Energy Technology Data Exchange (ETDEWEB)

    Porter, T.R. [Tuboscope Pipeline Services, Houston, TX (United States); Marr, J.E. [Marr and Associates, A Tuboscope Company, Calgary, AB (Canada)

    2004-07-01

    While regulations call for safe and reliable operation of pipelines, business calls for economic return and reduced liability. This paper presented a system that provides rapid, comprehensive and economic improvements for pipeline integrity decision support. The first phase of a pipeline integrity management plan (IMP) involves the identification of integrity threats to the pipeline. This may involve 22 root causes as defined by the Pipeline Research Council International (PRCI), grouped into 9 categories of related failure types, further grouped into time related defect types. Time dependent defects include external corrosion, internal corrosion and stress corrosion cracking. Stable defects include manufacturing related or welding defects, while time independent defects include mechanical damage, incorrect operations and outside forces. In designing an IMP, high consequence areas (HCAs) must be defined along with the integrity threats that could affect the pipeline. A baseline risk assessment is then performed using data from the integrity threat models to identify risks areas, individual lines, pipe segments or joints. Integrity management decisions are made based on the outcome of initial assessments, resulting in integrity assessment tools such as in line inspection (ILI) technologies, direct assessment (DA), and hydrostatic testing. Pipeline engineers benefit from having ILI, DA and other data integrated and interacting with geographic information system (GIS) data. This paper presented the LinaView PRO{sup TM} IMP tool developed by Tuboscope that enhances dig smart excavation decision making; remediation and mitigation planning; responding to one-call emergency response; implementation of government regulations; HCA identification; integration of a wide variety of data; comprehensive dynamic segmentation; and, data validation in support of risk assessment. The objective of an IMP is the safe and reliable delivery system for oil and gas product to markets. 9

  20. Beam spread functions calculated using Feynman path integrals

    Science.gov (United States)

    Kilgo, Paul; Tessendorf, Jerry

    2017-07-01

    A method of solving the radiative transfer equation using Feynman path integrals (FPIs) is discussed. The FPI approach is a mathematical framework for computing multiple scattering in participating media. Its numerical behavior is not well known, and techniques are being developed to solve the FPI approach numerically. A missing numerical technique is detailed and used to calculate beam spread functions (BSFs), a commonly studied experimental property of many types of media. The calculations are compared against measured BSFs of sea ice. Analysis shows differently-shaped BSFs, and suggests the width parameter of the calculated BSF's Gaussian fit approaches a value in the limit of the number of path segments. A projection is attempted, but suggests a larger number of path segments would not increase the width of the calculated BSF. The trial suggests the approach is numerically stable, but requires further testing to ensure scientific accuracy.

  1. Data Integration The Relational Logic Approach

    CERN Document Server

    Genesereth, Michael

    2010-01-01

    Data integration is a critical problem in our increasingly interconnected but inevitably heterogeneous world. There are numerous data sources available in organizational databases and on public information systems like the World Wide Web. Not surprisingly, the sources often use different vocabularies and different data structures, being created, as they are, by different people, at different times, for different purposes. The goal of data integration is to provide programmatic and human users with integrated access to multiple, heterogeneous data sources, giving each user the illusion of a sin

  2. The Impact of Technology Integration through a Transformative Approach

    Science.gov (United States)

    Cubillos, Jo Ann

    2013-01-01

    The integration of technology into classroom instruction in K-12 schools remains problematic. The problems associated with this integration are troubling, as technology integration may change a teacher's pedagogy toward more innovative approaches that increase student achievement. The purpose of this study was to document teachers' experiences as…

  3. Postmodern Implications for Theoretical Integration of Counseling Approaches.

    Science.gov (United States)

    Hansen, James T.

    2002-01-01

    Theoretical integration refers to the conceptual unification of diverse counseling approaches. Contends that the general failure of integrative attempts is a by-product of the modernistic epistemic context in which the systems were considered and proposes an examination of common narrative features of counseling approaches in a postmodern…

  4. Integrating Ontological Data Sources Using Viewpoints-Based Approach

    Directory of Open Access Journals (Sweden)

    Bouchra Boulkroun

    2016-12-01

    Full Text Available Within the development of Internet and intranets, information integration from various data sources becomes increasingly important and more challenging issue. Recently, the trend in data integration has favored the semantic integration using ontologies. However, the existing ontology-based approaches do not support the aspect of data multi-representations, which is important in the development of multi-user applications. The motivation of this paper is to address a novel semantic integration approach based on ontologies and viewpoints paradigms. This contribution combines the advantages of existing ontology-based integration approaches while avoiding their drawbacks. The proposed integration approach is evaluated using query processing. Profiles are introduced to offer answers to users according to their viewpoints and choices.

  5. Integration of functional oxides with semiconductors

    CERN Document Server

    Demkov, Alexander A

    2014-01-01

    This unique book describes the basic physical principles of the oxide/semiconductor epitaxy and offers a view of the current state of the field. It shows how this technology enables large-scale integration of oxide electronic and photonic devices, and describes possible hybrid semiconductor/oxide systems. The book incorporates both theoretical and experimental advances to explore the heteroepitaxy of tuned functional oxides and semiconductors to identify material, device and characterization challenges, and to present the incredible potential in the realization of multifunctional devices and monolithic integration of materials and devices. This book also: ·         Discusses why semiconductor substrates are an excellent integration platform for making hybrid logic/sensor devices ·         Provides a brief introduction to the methods accessible to non-experts, before going into details of interest to the experts ·         Includes a detailed glossary that explains the specialized ter...

  6. Biomimetic Scaffold Design for Functional and Integrative Tendon Repair

    Science.gov (United States)

    Zhang, Xinzhi; Bogdanowicz, Danielle; Erisken, Cevat; Lee, Nancy M.; Lu, Helen H.

    2012-01-01

    Rotator cuff tears represent the most common shoulder injuries in the United States. The debilitating effect of this degenerative condition coupled with the high incidence of failure associated with existing graft choices underscore the clinical need for alternative grafting solutions. The two critical design criteria for the ideal tendon graft would require the graft to not only exhibit physiologically relevant mechanical properties but also be able to facilitate functional graft integration by promoting the regeneration of the native tendon-to-bone interface. Centered on these design goals, this review will highlight current approaches to functional and integrative tendon repair. In particular, the application of biomimetic design principles through the use of nanofiber- and nanocomposite-based scaffolds for tendon tissue engineering will be discussed. This review will begin with nanofiber-based approaches to functional tendon repair, followed by a section highlighting the exciting research on tendon-to-bone interface regeneration, with an emphasis on implementation of strategic biomimicry in nanofiber scaffold design and the concomitant formation of graded multi-tissue systems for integrative soft tissue repair. This review will conclude with a summary and future directions section. PMID:22244070

  7. On Quantum Field Theories in Operator and Functional Integral Formalisms

    CERN Document Server

    Teleki, A; Noga, Milan; Teleki, Aba

    2006-01-01

    Relations and isomorphisms between quantum field theories in operator and functional integral formalisms are analyzed from the viewpoint of inequivalent representations of commutator or anticommutator rings of field operators. A functional integral in quantum field theory cannot be regarded as a Newton-Lebesgue integral but rather as a formal object to which one associates distinct numerical values for different processes of its integration. By choosing an appropriate method for the integration of a given functional integral, one can select a single representation out of infinitely many inequivalent representations for an operator whose trace is expressed by the corresponding functional integral. These properties are demonstrated with two exactly solvable examples.

  8. An iterative approach of protein function prediction

    Directory of Open Access Journals (Sweden)

    Chi Xiaoxiao

    2011-11-01

    Full Text Available Abstract Background Current approaches of predicting protein functions from a protein-protein interaction (PPI dataset are based on an assumption that the available functions of the proteins (a.k.a. annotated proteins will determine the functions of the proteins whose functions are unknown yet at the moment (a.k.a. un-annotated proteins. Therefore, the protein function prediction is a mono-directed and one-off procedure, i.e. from annotated proteins to un-annotated proteins. However, the interactions between proteins are mutual rather than static and mono-directed, although functions of some proteins are unknown for some reasons at present. That means when we use the similarity-based approach to predict functions of un-annotated proteins, the un-annotated proteins, once their functions are predicted, will affect the similarities between proteins, which in turn will affect the prediction results. In other words, the function prediction is a dynamic and mutual procedure. This dynamic feature of protein interactions, however, was not considered in the existing prediction algorithms. Results In this paper, we propose a new prediction approach that predicts protein functions iteratively. This iterative approach incorporates the dynamic and mutual features of PPI interactions, as well as the local and global semantic influence of protein functions, into the prediction. To guarantee predicting functions iteratively, we propose a new protein similarity from protein functions. We adapt new evaluation metrics to evaluate the prediction quality of our algorithm and other similar algorithms. Experiments on real PPI datasets were conducted to evaluate the effectiveness of the proposed approach in predicting unknown protein functions. Conclusions The iterative approach is more likely to reflect the real biological nature between proteins when predicting functions. A proper definition of protein similarity from protein functions is the key to predicting

  9. A Unified Approach to Generalized Stirling Functions

    Institute of Scientific and Technical Information of China (English)

    Tianxiao HE

    2012-01-01

    Here presented is a unified approach to generalized Stirling functions by using generalized factorial functions,k-Gamma functions,generalized divided difference,and the unified expression of Stirling numbers defined in[16].Previous well-known Stirling functions introduced by Butzer and Hauss[4],Butzer,Kilbas,and Trujilloet[6]and others are included as particular cases of our generalization.Some basic properties related to our general pattern such as their recursive relations,generating functions,and asymptotic properties are discussed,which extend the corresponding results about the Stirling numbers shown in[21]to the defined Stirling functions.

  10. Wilber's Integral Theory and Dossey's Theory of Integral Nursing: An Examination of Two Integral Approaches in Nursing Scholarship.

    Science.gov (United States)

    Shea, Linda; Frisch, Noreen

    2016-09-01

    The purpose of this article is to examine Dossey's theory of integral nursing in relation to its major theoretical source, Wilber's integral theory. Although several nursing scholars have written about integral theory in relation to nursing scholarship and practice, Dossey's theory of integral nursing may be influencing how nurses take up integral theory in a significant way due to an extensive outreach in the holistic nursing community. Despite this wide circulation, the theory of integral nursing has yet to be reviewed in the nursing literature. This article (a) compares Dossey's theory of integral nursing with Wilber's integral theory and (b) contrasts Dossey's integral approach with another integral approach used by other scholars of integral theory. © The Author(s) 2015.

  11. Analysis of radial basis function interpolation approach

    Institute of Scientific and Technical Information of China (English)

    Zou You-Long; Hu Fa-Long; Zhou Can-Can; Li Chao-Liu; Dunn Keh-Jim

    2013-01-01

    The radial basis function (RBF) interpolation approach proposed by Freedman is used to solve inverse problems encountered in well-logging and other petrophysical issues. The approach is to predict petrophysical properties in the laboratory on the basis of physical rock datasets, which include the formation factor, viscosity, permeability, and molecular composition. However, this approach does not consider the effect of spatial distribution of the calibration data on the interpolation result. This study proposes a new RBF interpolation approach based on the Freedman's RBF interpolation approach, by which the unit basis functions are uniformly populated in the space domain. The inverse results of the two approaches are comparatively analyzed by using our datasets. We determine that although the interpolation effects of the two approaches are equivalent, the new approach is more flexible and beneficial for reducing the number of basis functions when the database is large, resulting in simplification of the interpolation function expression. However, the predicted results of the central data are not sufficiently satisfied when the data clusters are far apart.

  12. String operator formalism and functional integral in holomorphic representation

    Energy Technology Data Exchange (ETDEWEB)

    Losev, A.; Morozov, A.; Rosly, A.; Shatashvili, S.

    1989-01-05

    We discuss the relation between the functional integral over open Riemann surfaces and the operator formalism on closed Riemann surfaces. The states in the latter formalism arise in the holomorphic representation of the functional integral.

  13. Integration of functional complex oxide nanomaterials on silicon

    Directory of Open Access Journals (Sweden)

    Jose Manuel eVila-Fungueiriño

    2015-06-01

    Full Text Available The combination of standard wafer-scale semiconductor processing with the properties of functional oxides opens up to innovative and more efficient devices with high value applications that can be produced at large scale. This review uncovers the main strategies that are successfully used to monolithically integrate functional complex oxide thin films and nanostructures on silicon: the chemical solution deposition approach (CSD and the advanced physical vapor deposition techniques such as oxide molecular beam epitaxy (MBE. Special emphasis will be placed on complex oxide nanostructures epitaxially grown on silicon using the combination of CSD and MBE. Several examples will be exposed, with a particular stress on the control of interfaces and crystallization mechanisms on epitaxial perovskite oxide thin films, nanostructured quartz thin films, and octahedral molecular sieve nanowires. This review enlightens on the potential of complex oxide nanostructures and the combination of both chemical and physical elaboration techniques for novel oxide-based integrated devices.

  14. Investigation of Integrated Vehicle Health Management Approaches

    Science.gov (United States)

    Paris, Deidre

    2005-01-01

    This report is to present the work that was performed during the summer in the Advance Computing Application office. The NFFP (NASA Faculty Fellow Program) had ten summer faculty members working on IVHM (Integrated Vehicle Health Management) technologies. The objective of this project was two-fold: 1) to become familiar with IVHM concepts and key demonstrated IVHM technologies; and 2) to integrate the research that has been performed by IVHM faculty members into the MASTLAB (Marshall Avionic Software Test Lab). IVHM is a NASA-wide effort to coordinate, integrate and apply advanced software, sensors and design technologies to increase the level of intelligence, autonomy, and health state of future vehicles. IVHM is an important concept because it is consistent with the current plan for NASA to go to the moon, mars, and beyond. In order for NASA to become more involved in deep exploration, avionic systems will need to be highly adaptable and autonomous.

  15. Local-basis-function approach to computed tomography

    Science.gov (United States)

    Hanson, K. M.; Wecksung, G. W.

    1985-12-01

    In the local basis-function approach, a reconstruction is represented as a linear expansion of basis functions, which are arranged on a rectangular grid and possess a local region of support. The basis functions considered here are positive and may overlap. It is found that basis functions based on cubic B-splines offer significant improvements in the calculational accuracy that can be achieved with iterative tomographic reconstruction algorithms. By employing repetitive basis functions, the computational effort involved in these algorithms can be minimized through the use of tabulated values for the line or strip integrals over a single-basis function. The local nature of the basis functions reduces the difficulties associated with applying local constraints on reconstruction values, such as upper and lower limits. Since a reconstruction is specified everywhere by a set of coefficients, display of a coarsely represented image does not require an arbitrary choice of an interpolation function.

  16. Field theory a path integral approach

    CERN Document Server

    Das, Ashok

    2006-01-01

    This unique book describes quantum field theory completely within the context of path integrals. With its utility in a variety of fields in physics, the subject matter is primarily developed within the context of quantum mechanics before going into specialized areas.Adding new material keenly requested by readers, this second edition is an important expansion of the popular first edition. Two extra chapters cover path integral quantization of gauge theories and anomalies, and a new section extends the supersymmetry chapter, where singular potentials in supersymmetric systems are described.

  17. Integrated System Health Management: Foundational Concepts, Approach, and Implementation.

    Science.gov (United States)

    Figueroa, Fernando; Schmalzel, John; Walker, Mark; Venkatesh, Meera; Kapadia, Ravi; Morris, Jon; Turowski, Mark; Smith, Harvey

    2009-01-01

    Implementation of integrated system health management (ISHM) capability is fundamentally linked to the management of data, information, and knowledge (DIaK) with the purposeful objective of determining the health of a system. It is akin to having a team of experts who are all individually and collectively observing and analyzing a complex system, and communicating effectively with each other in order to arrive to an accurate and reliable assessment of its health. We present concepts, procedures, and a specific approach as a foundation for implementing a credible ISHM capability. The capability stresses integration of DIaK from all elements of a system. The intent is also to make possible implementation of on-board ISHM capability, in contrast to a remote capability. The information presented is the result of many years of research, development, and maturation of technologies, and of prototype implementations in operational systems (rocket engine test facilities). The paper will address the following topics: 1. ISHM Model of a system 2. Detection of anomaly indicators. 3. Determination and confirmation of anomalies. 4. Diagnostic of causes and determination of effects. 5. Consistency checking cycle. 6. Management of health information 7. User Interfaces 8. Example implementation ISHM has been defined from many perspectives. We define it as a capability that might be achieved by various approaches. We describe a specific approach that has been matured throughout many years of development, and pilot implementations. ISHM is a capability that is achieved by integrating data, information, and knowledge (DIaK) that might be distributed throughout the system elements (which inherently implies capability to manage DIaK associated with distributed sub-systems). DIaK must be available to any element of a system at the right time and in accordance with a meaningful context. ISHM Functional Capability Level (FCL) is measured by how well a system performs the following

  18. Functional capacity evaluation: an empirical approach.

    Science.gov (United States)

    Jette, A M

    1980-02-01

    This paper presents an empirical approach to selecting activities of daily living (ADL) to assess the functional capacity of noninstitutionalized individuals with polyarticular disability. The results of structural analyses illustrate the feasibility of substantially reducing the task of assessing functional capacity with a subset of ADL items without sacrificing the comprehensiveness of the assessment. The analyses reveal 5 common functional categories: physical mobility, transfers, home chores, kitchen chores, and personal care, which account for over 50% of the variance in the data.

  19. Painlevé equations, elliptic integrals and elementary functions

    Science.gov (United States)

    Żołądek, Henryk; Filipuk, Galina

    2015-02-01

    The six Painlevé equations can be written in the Hamiltonian form, with time dependent Hamilton functions. We present a rather new approach to this result, leading to rational Hamilton functions. By a natural extension of the phase space one gets corresponding autonomous Hamiltonian systems with two degrees of freedom. We realize the Bäcklund transformations of the Painlevé equations as symplectic birational transformations in C4 and we interpret the cases with classical solutions as the cases of partial integrability of the extended Hamiltonian systems. We prove that the extended Hamiltonian systems do not have any additional algebraic first integral besides the known special cases of the third and fifth Painlevé equations. We also show that the original Painlevé equations admit the first integrals expressed in terms of the elementary functions only in the special cases mentioned above. In the proofs we use equations in variations with respect to a parameter and Liouville's theory of elementary functions.

  20. Integrating phosphorylation network with transcriptional network reveals novel functional relationships.

    Directory of Open Access Journals (Sweden)

    Lin Wang

    Full Text Available Phosphorylation and transcriptional regulation events are critical for cells to transmit and respond to signals. In spite of its importance, systems-level strategies that couple these two networks have yet to be presented. Here we introduce a novel approach that integrates the physical and functional aspects of phosphorylation network together with the transcription network in S.cerevisiae, and demonstrate that different network motifs are involved in these networks, which should be considered in interpreting and integrating large scale datasets. Based on this understanding, we introduce a HeRS score (hetero-regulatory similarity score to systematically characterize the functional relevance of kinase/phosphatase involvement with transcription factor, and present an algorithm that predicts hetero-regulatory modules. When extended to signaling network, this approach confirmed the structure and cross talk of MAPK pathways, inferred a novel functional transcription factor Sok2 in high osmolarity glycerol pathway, and explained the mechanism of reduced mating efficiency upon Fus3 deletion. This strategy is applicable to other organisms as large-scale datasets become available, providing a means to identify the functional relationships between kinases/phosphatases and transcription factors.

  1. Design of Integrated Circuits Approaching Terahertz Frequencies

    DEFF Research Database (Denmark)

    Yan, Lei

    In this thesis, monolithic microwave integrated circuits(MMICs) are presented for millimeter-wave and submillimeter-wave or terahertz(THz) applications. Millimeter-wave power generation from solid state devices is not only crucial for the emerging high data rate wireless communications but also...

  2. Development of Multisensory Integration Approach Model

    Science.gov (United States)

    Kumar, S. Prasanna; Nathan, B. Sami

    2016-01-01

    Every teacher expects optimum level of processing in mind of them students. The level of processing is mainly depends upon memory process. Most of the students have retrieval difficulties on past learning. Memory difficulties directly related to sensory integration. In these circumstances the investigator made an attempt to construct Multisensory…

  3. Integrative Life Planning: A Holistic Approach

    Science.gov (United States)

    Hansen, Sunny Sundal

    2011-01-01

    This article presents a brief description of integrative life planning (ILP), the career theory/concept created in the 1990s by the author. It describes what she calls "the heart of ILP," the 6 critical life tasks and their applications.

  4. Ramjets: Thermal Management an Integrated Engineering Approach

    Science.gov (United States)

    2010-09-01

    and Thermal Management (Propulsion a vitesse elevee : Conception du moteur - integration et gestion thermique ) 14. ABSTRACT Within the framework of...a central body extending from the nose tip to the end of the plug nozzle. At the front end of the annular combustor the fuel (assumed to be Jet-A

  5. Some Approaches for Integration of Specification Techniques

    DEFF Research Database (Denmark)

    Haxthausen, Anne Elisabeth

    2000-01-01

    It is often useful to apply several specification techniques within the same software development project. This raises the question how specification techniques can be integrated. In this presentation we give three different examples of how this can be done. In the first example, we summarise how...

  6. An integrative approach to apprehend desistance.

    Science.gov (United States)

    F-Dufour, Isabelle; Brassard, Renée; Martel, Joane

    2015-05-01

    The process underlying desistance is still a strong subject of debate. This article seeks to introduce several core concepts of Archer's morphogenic approach to study how people desist from crime. At first, it discusses the primary existing theories of desistance. Then, this article demonstrates the usefulness of this approach by presenting empirical evidence drawn from semistructured interviews collected with 29 men who desisted from crime in an eastern province of Canada. The study demonstrates how this alternative approach allows for the consolidation of existing knowledge on desistance. Then implication of these findings for both theory and practice are discussed.

  7. An integrative computational approach for prioritization of genomic variants.

    Directory of Open Access Journals (Sweden)

    Inna Dubchak

    Full Text Available An essential step in the discovery of molecular mechanisms contributing to disease phenotypes and efficient experimental planning is the development of weighted hypotheses that estimate the functional effects of sequence variants discovered by high-throughput genomics. With the increasing specialization of the bioinformatics resources, creating analytical workflows that seamlessly integrate data and bioinformatics tools developed by multiple groups becomes inevitable. Here we present a case study of a use of the distributed analytical environment integrating four complementary specialized resources, namely the Lynx platform, VISTA RViewer, the Developmental Brain Disorders Database (DBDB, and the RaptorX server, for the identification of high-confidence candidate genes contributing to pathogenesis of spina bifida. The analysis resulted in prediction and validation of deleterious mutations in the SLC19A placental transporter in mothers of the affected children that causes narrowing of the outlet channel and therefore leads to the reduced folate permeation rate. The described approach also enabled correct identification of several genes, previously shown to contribute to pathogenesis of spina bifida, and suggestion of additional genes for experimental validations. The study demonstrates that the seamless integration of bioinformatics resources enables fast and efficient prioritization and characterization of genomic factors and molecular networks contributing to the phenotypes of interest.

  8. An Integrative Computational Approach for Prioritization of Genomic Variants

    Science.gov (United States)

    Wang, Sheng; Meyden, Cem; Sulakhe, Dinanath; Poliakov, Alexander; Börnigen, Daniela; Xie, Bingqing; Taylor, Andrew; Ma, Jianzhu; Paciorkowski, Alex R.; Mirzaa, Ghayda M.; Dave, Paul; Agam, Gady; Xu, Jinbo; Al-Gazali, Lihadh; Mason, Christopher E.; Ross, M. Elizabeth; Maltsev, Natalia; Gilliam, T. Conrad

    2014-01-01

    An essential step in the discovery of molecular mechanisms contributing to disease phenotypes and efficient experimental planning is the development of weighted hypotheses that estimate the functional effects of sequence variants discovered by high-throughput genomics. With the increasing specialization of the bioinformatics resources, creating analytical workflows that seamlessly integrate data and bioinformatics tools developed by multiple groups becomes inevitable. Here we present a case study of a use of the distributed analytical environment integrating four complementary specialized resources, namely the Lynx platform, VISTA RViewer, the Developmental Brain Disorders Database (DBDB), and the RaptorX server, for the identification of high-confidence candidate genes contributing to pathogenesis of spina bifida. The analysis resulted in prediction and validation of deleterious mutations in the SLC19A placental transporter in mothers of the affected children that causes narrowing of the outlet channel and therefore leads to the reduced folate permeation rate. The described approach also enabled correct identification of several genes, previously shown to contribute to pathogenesis of spina bifida, and suggestion of additional genes for experimental validations. The study demonstrates that the seamless integration of bioinformatics resources enables fast and efficient prioritization and characterization of genomic factors and molecular networks contributing to the phenotypes of interest. PMID:25506935

  9. The meaning of integrated care: a systems approach

    Directory of Open Access Journals (Sweden)

    Lars Edgren

    2008-10-01

    Full Text Available Introduction: Organizations can be regarded as systems. The traditional model of systems views them as machines. This seems to be insufficient when it comes to understanding and organizing complex tasks. To better understand integrated care we should approach organizations as constantly changing living organisms, where many agents are interconnected in so-called Complex Adaptive Systems (CAS. Theory and discussion: The term “complex” emphasizes that the necessary competence to perform a task is not owned by any one part, but comes as a result of co-operation within the system. “Adaptive” means that system change occurs through successive adaptations. A CAS consists of several subsystems called agents, which act in dependence of one another. Examples would be the ant-hill, the human immune defence, the financial market and the surgical operating theatre team. Studying a CAS, the focus is on the interaction and communication between agents. Although these thoughts are not new, the CAS-approach has not yet been widely applied to the management of integrated care. This helps the management to understand why the traditional top down way of managing, following the machine model thinking, may meet with problems in interdependent organizations with complex tasks. Conclusion: When we perceive health and social services as CASs we should gain more insight into the processes that go on within and between organizations and how top management, for example within a hospital, in fact executes its steering function.

  10. Valuing groundwater: A practical approach for integrating ...

    African Journals Online (AJOL)

    groundwater economic values into decision making ... The methodology incorporates a 2-tiered valuation approach. .... groundwater systems in Botswana (SADC, 2010). .... tion) can be investigated to support water resource management.

  11. Certain Integral Transform and Fractional Integral Formulas for the Generalized Gauss Hypergeometric Functions

    Directory of Open Access Journals (Sweden)

    Junesang Choi

    2014-01-01

    Full Text Available A remarkably large number of integral transforms and fractional integral formulas involving various special functions have been investigated by many authors. Very recently, Agarwal gave some integral transforms and fractional integral formulas involving the Fp(α,β(·. In this sequel, using the same technique, we establish certain integral transforms and fractional integral formulas for the generalized Gauss hypergeometric functions Fp(α,β,m(·. Some interesting special cases of our main results are also considered.

  12. Approaches in integrative bioinformatics towards the virtual cell

    CERN Document Server

    Chen, Ming

    2014-01-01

    Approaches in Integrative Bioinformatics provides a basic introduction to biological information systems, as well as guidance for the computational analysis of systems biology. This book also covers a range of issues and methods that reveal the multitude of omics data integration types and the relevance that integrative bioinformatics has today. Topics include biological data integration and manipulation, modeling and simulation of metabolic networks, transcriptomics and phenomics, and virtual cell approaches, as well as a number of applications of network biology. It helps to illustrat

  13. A Functional Approach to User Guides

    DEFF Research Database (Denmark)

    Nielsen, Sandro

    2007-01-01

    The functional approach opens up exciting new possibilities for theoretical and practical lexicography. It encourages lexicographers to adopt a new way of thinking when planning and compiling dictionaries and when discussing and developing new lexicographic principles. One area in which it impacts...... to fulfil the requirements of users. By applying the functional approach lexicographers are forced to reconsider the scope of the user guide. The user guide has traditionally centred on the structures of entries - and consequently on the word list - but its scope should be widened, so as to include all......-oriented and/or cognitive functions and relate the data in the entire dictionary, not merely the entries, to these functions. Finally, the lexicographers should consider the classes of language functions involved in writing user guides. In order to guide and instruct the user in the best way possible, user...

  14. Integrated approaches to warehouse planning and operations

    OpenAIRE

    Geraldes, Carla A. S.

    2010-01-01

    In this talk we discuss a tactical model recently available in warehouse literature. The model integrates the replenishment decision in inventory management, the allocation of products to warehousing systems and the assignment of products to storage locations in warehousing management. Our aim is to show the models’ potentialities and weaknesses when applied to a wide variety of problems and to identify challenging research opportunities for developing global warehouse decision support mod...

  15. The line integral approach to radarclinometry

    Science.gov (United States)

    Wildey, R.L.

    1987-01-01

    Radarclinometry, the invention of which has been previously reported, is a technique for deriving a topographic map from a single radar image by using the dependence upon terrain-surface orientation of the integrated signal of an individual image pixel. The radiometric calibration required for precise operation and testing does not yet exist, but the imminence of important applications justifies parallel, rather than serial, development of radarclinometry and radiometrically calibrated radar. The present investigation reports three developmental advances: (1) The solid angle of integration of back-scattered specific intensity constituting a pixel signal is more accurately accounted for in its dependence on surface orientation than in previous work. (2) The local curvature hypothesis, which removes the requirement of a ground-truth profile as a boundary condition and enables the formulation of the theory in terms of a line integral, has been expanded to include the three possibilities of Local Cylindricity, Local Biaxial Ellipsoidal Hyperbolicity, and Least-Squares Local Sphericity. (3) The theory is integrated in the cross-ground-range direction, which is ill-conditioned compared to the ground-range direction, whereas the original formulation was based on enforced isotropy in the two-dimensional power spectrum of the topography. It was found necessary to prohibit the hypothesis of Local Biaxial Ellipsoidal Hyperbolicity in the cross-range stepping, for reasons not completely clear. Variation in the proportioning between curvature assumptions had produced topographic maps that are in good mutual agreement but not realistic in appearance. They are severely banded parallel to the ground-range direction, most especially at small radar zenith angles. Numerical experimentation with the falsification of topography through incorrect decalibration as performed on a Gaussian hill suggests that the banding and its exaggeration at high radar incidence angles could easily be

  16. AREA INTEGRAL FUNCTIONS FOR SECTORIAL OPERATORS ON Lp SPACES

    Institute of Scientific and Technical Information of China (English)

    陈泽亁; 孙牧

    2014-01-01

    Area integral functions are introduced for sectorial operators on Lp-spaces. We establish the equivalence between the square and area integral functions for sectorial operators on Lp spaces. This follows that the results of Cowling, Doust, McIntosh, Yagi, and Le Merdy on H∞ functional calculus of sectorial operators on Lp-spaces hold true when the square functions are replaced by the area integral functions.

  17. An integrated Boltzmann+hydrodynamics approach to heavy ion collisions

    Energy Technology Data Exchange (ETDEWEB)

    Petersen, Hannah

    2009-04-22

    In this thesis the first fully integrated Boltzmann+hydrodynamics approach to relativistic heavy ion reactions has been developed. After a short introduction that motivates the study of heavy ion reactions as the tool to get insights about the QCD phase diagram, the most important theoretical approaches to describe the system are reviewed. The hadron-string transport approach that this work is based on is the Ultra-relativistic Quantum Molecular Dynamics (UrQMD) approach. Predictions for the charged particle multiplicities at LHC energies are made. The next step is the development of a new framework to calculate the baryon number density in a transport approach. Time evolutions of the net baryon number and the quark density have been calculated at AGS, SPS and RHIC energies. Studies of phase diagram trajectories using hydrodynamics are performed. The hybrid approach that has been developed as the main part of this thesis is based on the UrQMD transport approach with an intermediate hydrodynamical evolution for the hot and dense stage of the collision. The full (3+1) dimensional ideal relativistic one fluid dynamics evolution is solved using the SHASTA algorithm. Three different equations of state have been used, namely a hadron gas equation of state without a QGP phase transition, a chiral EoS and a bag model EoS including a strong first order phase transition. For the freeze-out transition from hydrodynamics to the cascade calculation two different set-ups are employed. The parameter dependences of the model are investigated and the time evolution of different quantities is explored. The hybrid model calculation is able to reproduce the experimentally measured integrated as well as transverse momentum dependent v{sub 2} values for charged particles. The multiplicity and mean transverse mass excitation function is calculated for pions, protons and kaons in the energy range from E{sub lab}=2-160 A GeV. The HBT correlation of the negatively charged pion source

  18. Integrated care for diabetes - The Singapore Approach

    Directory of Open Access Journals (Sweden)

    Su Qian Yeo

    2012-03-01

    Full Text Available Background The prevalence of diabetes mellitus is 12.7% in Singapore. Managing people with diabetes in the community may be needed to reduce unnecessary utilisation of expensive specialist resources and to reduce hospital waiting times for patients with complications. Care Practice The Singapore General Hospital (SGH Delivering on Target (DOT Programme was launched in 2005 to right-site clinically stable diabetic patients from the hospital to private DOT GPs. The Chronic Disease Management Office (CDMO was established and a fully customised DOT information technology (IT system was developed. Three initiatives were implemented: (i Subsidised Drug Delivery Programme, (ii Diagnostic Tests Incentive Programme, and (iii Allied Healthcare Incentive Programme. Discussion Right-siting was enabled through patient incentives that eased the burden of out-of-pocket expenditure. Right Siting Officers (RSOs maintained a general oversight of the patient pathway. The integrated system supported shared care follow-up by enabling DOT GPs to share updates on the patients' health status with the referring specialists. Conclusion A coherent process across all healthcare providers similar to the SGH DOT Programme may facilitate efforts to shift the care for people with diabetes to the community and to provide integrated care. Successful integration may require incentives for institutional partners and patients.

  19. Concept for integrated environmental monitoring. Scientific approach

    Energy Technology Data Exchange (ETDEWEB)

    Haber, W. [comp.; Schoenthaler, K.; Kerner, H.F.; Koeppel, J.; Spandau, L.

    1998-09-01

    Despite considerable expenditures for environmental protection and intensified efforts in the areas of environmental research and monitoring, environmental damage increasingly occurs, sometimes with global effects, largely due to the lack of early diagnosis. In the past few years various institutions have therefore demanded improvements in environmental monitoring. The Council of Experts on Environmental Issues (`Rat von Sachverstaendigen fuer Umweltfragen`, SRU), in particular, in its `Environmental Report` of 1987 and in its Special Report on `General Ecological Environmental Monitoring` (1990) presented far-reaching demands for a nationwide ecological early warning system which should integrate the various local, regional, national, and even global monitoring levels, and which should encompass an environmental monitoring of entire ecosystems at representative locations. This is aimed at creating the prerequisites for - detection of long-term gradual environmental change, - confirmation of refutation of initial assumptions regarding the causes of these environmental changes, - permitting decisions on preventive actions to stabilize or improve environmental conditions and - making it possible to assess the success of environmental protection policies. This report includes an abbreviated version and documentation of the conference on the `Concept for Integrated Environmental Monitoring` and the final report `Specification of the Concept for Integrated Environmental Monitoring from the Perspective of Nature Conservation`. (orig.)

  20. The Feynman-Vernon Influence Functional Approach in QED

    Science.gov (United States)

    Biryukov, Alexander; Shleenkov, Mark

    2016-10-01

    In the path integral approach we describe evolution of interacting electromagnetic and fermionic fields by the use of density matrix formalism. The equation for density matrix and transitions probability for fermionic field is obtained as average of electromagnetic field influence functional. We obtain a formula for electromagnetic field influence functional calculating for its various initial and final state. We derive electromagnetic field influence functional when its initial and final states are vacuum. We present Lagrangian for relativistic fermionic field under influence of electromagnetic field vacuum.

  1. The Feynman-Vernon Influence Functional Approach in QED

    Directory of Open Access Journals (Sweden)

    Biryukov Alexander

    2016-01-01

    Full Text Available In the path integral approach we describe evolution of interacting electromagnetic and fermionic fields by the use of density matrix formalism. The equation for density matrix and transitions probability for fermionic field is obtained as average of electromagnetic field influence functional. We obtain a formula for electromagnetic field influence functional calculating for its various initial and final state. We derive electromagnetic field influence functional when its initial and final states are vacuum. We present Lagrangian for relativistic fermionic field under influence of electromagnetic field vacuum.

  2. XML Data Integrity Based on Concatenated Hash Function

    CERN Document Server

    Liu, Baolong; Yip, Jim

    2009-01-01

    Data integrity is the fundamental for data authentication. A major problem for XML data authentication is that signed XML data can be copied to another document but still keep signature valid. This is caused by XML data integrity protecting. Through investigation, the paper discovered that besides data content integrity, XML data integrity should also protect element location information, and context referential integrity under fine-grained security situation. The aim of this paper is to propose a model for XML data integrity considering XML data features. The paper presents an XML data integrity model named as CSR (content integrity, structure integrity, context referential integrity) based on a concatenated hash function. XML data content integrity is ensured using an iterative hash process, structure integrity is protected by hashing an absolute path string from root node, and context referential integrity is ensured by protecting context-related elements. Presented XML data integrity model can satisfy int...

  3. Evaluating an Integrated Approach to the Management of Cerebral Palsy. Appendix B: Field Test Report of the Eau Claire Functional Abilities Test and the Wolfe-Bluel Socialization Inventory. Volume III of IV. Final Report.

    Science.gov (United States)

    Heal, Laird W.

    The appendix examined the measurement instruments developed in the course of the Integrated Management of Cerebral Palsy project to measure functional movements and socialization skills of severly handicapped, nonambulatory cerebral palsied children who had limited speech. The field test sample consisted of 51 cases for the Eau Claire Functional…

  4. Strategic Technology Investment Analysis: An Integrated System Approach

    Science.gov (United States)

    Adumitroaie, V.; Weisbin, C. R.

    2010-01-01

    Complex technology investment decisions within NASA are increasingly difficult to make such that the end results are satisfying the technical objectives and all the organizational constraints. Due to a restricted science budget environment and numerous required technology developments, the investment decisions need to take into account not only the functional impact on the program goals, but also development uncertainties and cost variations along with maintaining a healthy workforce. This paper describes an approach for optimizing and qualifying technology investment portfolios from the perspective of an integrated system model. The methodology encompasses multi-attribute decision theory elements and sensitivity analysis. The evaluation of the degree of robustness of the recommended portfolio provides the decision-maker with an array of viable selection alternatives, which take into account input uncertainties and possibly satisfy nontechnical constraints. The methodology is presented in the context of assessing capability development portfolios for NASA technology programs.

  5. Strategic Technology Investment Analysis: An Integrated System Approach

    Science.gov (United States)

    Adumitroaie, V.; Weisbin, C. R.

    2010-01-01

    Complex technology investment decisions within NASA are increasingly difficult to make such that the end results are satisfying the technical objectives and all the organizational constraints. Due to a restricted science budget environment and numerous required technology developments, the investment decisions need to take into account not only the functional impact on the program goals, but also development uncertainties and cost variations along with maintaining a healthy workforce. This paper describes an approach for optimizing and qualifying technology investment portfolios from the perspective of an integrated system model. The methodology encompasses multi-attribute decision theory elements and sensitivity analysis. The evaluation of the degree of robustness of the recommended portfolio provides the decision-maker with an array of viable selection alternatives, which take into account input uncertainties and possibly satisfy nontechnical constraints. The methodology is presented in the context of assessing capability development portfolios for NASA technology programs.

  6. Founding Editorial: Embryology — An Integrated Approach

    Directory of Open Access Journals (Sweden)

    Michael Richardson

    2001-01-01

    Full Text Available We introduce the Embryology domain of TheScientificWorld and outline the scope and aims. We argue for an interdisciplinary approach to problems in develop-mental biology. Three areas are identified as being of particular relevance to this domain: evolutionary developmental biology, teratology, and descriptive or experimental embryology.

  7. New Theoretical Approach Integrated Education and Technology

    Science.gov (United States)

    Ding, Gang

    2010-01-01

    The paper focuses on exploring new theoretical approach in education with development of online learning technology, from e-learning to u-learning and virtual reality technology, and points out possibilities such as constructing a new teaching ecological system, ubiquitous educational awareness with ubiquitous technology, and changing the…

  8. ESCO in Danish municipalities: Basic, integrative or strategic approaches?

    DEFF Research Database (Denmark)

    Jensen, Jesper Ole; Hansen, Jesper Rohr

    2012-01-01

    , with relatively few buildings, energy retrofitting and low investments, the integrative and strategic approach include a higher degree of partnership, a more ambitious building renovation approach, and more innovative understandings of facilities management. We also compare ESCO with energy retrofitting as an in...... municipalities see an in-house approach as a better alternative. Approach (Theory/Methodology): Our research is based on literature studies and on qualitative interviews with Danish municipalities carrying out ESCO projects, as well as with ESCO providers. Results: Our studies suggest that different ESCO...... approaches are being used in Danish municipalities, which we label the basic, the integrated and the strategic ESCO approaches. The three approaches include different ambitions, technologies, economies and innovation potentials. Whereas the basic approach implies a ‘traditional’ guarantee-based model...

  9. A functional approach to the TMJ disorders.

    Science.gov (United States)

    Deodato, F; Cristiano, S; Trusendi, R; Giorgetti, R

    2003-01-01

    This manuscript describes our conservative approach to treatment of TMJ disorders. The method we use had been suggested by Rocabado - its aims are: joint distraction by the elimination of compression, restoration of physiologic articular rest, mobilization of the soft tissues, and whenever possible, to improve the condyle-disk-glenoid fossa relationship. To support these claims two clinical cases are presented where the non-invasive therapy was successful. The results obtained confirm the validity of this functional approach.

  10. Urban energy systems an integrated approach

    CERN Document Server

    Keirstead, James

    2013-01-01

    Energy demands of cities need to be met more sustainably. This book analyses the technical and social systems that satisfy these needs and asks how methods can be put into practice to achieve this.Drawing on analytical tools and case studies developed at Imperial College London, the book presents state-of-the-art techniques for examining urban energy systems as integrated systems of technologies, resources, and people.Case studies include:a history of the evolution of London's urban energy system, from pre-history to present daya history of the growth of d

  11. The Role of an Integrated Approach in Music Education Technology

    Directory of Open Access Journals (Sweden)

    Natalia Popovych

    2014-04-01

    Full Text Available The purpose of this paper is to justify the role of integrated approach to music education of students. This requires the implementation of a theoretical analysis of the meaning and importance of an integrated approach to music education and training, determination of didactic conditions of integrating the music education in schools and coverage of methods of arrangement of the complex relationships of the main types of educational and creative activity for students in music lessons. It is proved that an integrated approach to the music education process causes the appearance of new original teaching forms and techniques that brings the process to a new qualitative level, enriching the musical and creative abilities of students, enabling them to realize the artistic and aesthetic taste preferences, to achieve the integrity of musical and creative development and high levels of formation of aesthetic consciousness and music.

  12. Area integral functions and $H^{\\8}$ functional calculus for sectorial operators on Hilbert spaces

    OpenAIRE

    Chen, Zeqian; Sun, Mu

    2012-01-01

    Area integral functions are introduced for sectorial operators on Hilbert spaces. We establish the equivalence relationship between the square and area integral functions. This immediately extends McIntosh/Yagi's results on $H^{\\8}$ functional calculus of sectorial operators on Hilbert spaces to the case when the square functions are replaced by the area integral functions.

  13. An integrated systems engineering approach to aircraft design

    Science.gov (United States)

    Price, M.; Raghunathan, S.; Curran, R.

    2006-06-01

    The challenge in Aerospace Engineering, in the next two decades as set by Vision 2020, is to meet the targets of reduction of nitric oxide emission by 80%, carbon monoxide and carbon dioxide both by 50%, reduce noise by 50% and of course with reduced cost and improved safety. All this must be achieved with expected increase in capacity and demand. Such a challenge has to be in a background where the understanding of physics of flight has changed very little over the years and where industrial growth is driven primarily by cost rather than new technology. The way forward to meet the challenges is to introduce innovative technologies and develop an integrated, effective and efficient process for the life cycle design of aircraft, known as systems engineering (SE). SE is a holistic approach to a product that comprises several components. Customer specifications, conceptual design, risk analysis, functional analysis and architecture, physical architecture, design analysis and synthesis, and trade studies and optimisation, manufacturing, testing validation and verification, delivery, life cycle cost and management. Further, it involves interaction between traditional disciplines such as Aerodynamics, Structures and Flight Mechanics with people- and process-oriented disciplines such as Management, Manufacturing, and Technology Transfer. SE has become the state-of-the-art methodology for organising and managing aerospace production. However, like many well founded methodologies, it is more difficult to embody the core principles into formalised models and tools. The key contribution of the paper will be to review this formalisation and to present the very latest knowledge and technology that facilitates SE theory. Typically, research into SE provides a deeper understanding of the core principles and interactions, and helps one to appreciate the required technical architecture for fully exploiting it as a process, rather than a series of events. There are major issues as

  14. [Partial lease squares approach to functional analysis].

    Science.gov (United States)

    Preda, C

    2006-01-01

    We extend the partial least squares (PLS) approach to functional data represented in our models by sample paths of stochastic process with continuous time. Due to the infinite dimension, when functional data are used as a predictor for linear regression and classification models, the estimation problem is an ill-posed one. In this context, PLS offers a simple and efficient alternative to the methods based on the principal components of the stochastic process. We compare the results given by the PLS approach and other linear models using several datasets from economy, industry and medical fields.

  15. FUZZY-DISTANCE FUNCTION APPROACH FOR MULTIPLE CRITERIA DECISION MAKING

    Directory of Open Access Journals (Sweden)

    Mayank Kumar

    2012-06-01

    Full Text Available In this paper, a method for decision making using fuzzy integral and distance function is presented. Case studies of multiple-response process with correlated responses are used to illustrate the effective application of the proposed approach. The efficacy of this method is compared with the existing methods of MCDM like TOPSIS and GRA. The proposed method is robust, requires less information and less complex as compared to many existing methods.

  16. Challenges and opportunities for integrating lake ecosystem modelling approaches

    Science.gov (United States)

    Mooij, Wolf M.; Trolle, Dennis; Jeppesen, Erik; Arhonditsis, George; Belolipetsky, Pavel V.; Chitamwebwa, Deonatus B.R.; Degermendzhy, Andrey G.; DeAngelis, Donald L.; Domis, Lisette N. De Senerpont; Downing, Andrea S.; Elliott, J. Alex; Ruberto, Carlos Ruberto; Gaedke, Ursula; Genova, Svetlana N.; Gulati, Ramesh D.; Hakanson, Lars; Hamilton, David P.; Hipsey, Matthew R.; Hoen, Jochem 't; Hulsmann, Stephan; Los, F. Hans; Makler-Pick, Vardit; Petzoldt, Thomas; Prokopkin, Igor G.; Rinke, Karsten; Schep, Sebastiaan A.; Tominaga, Koji; Van Dam, Anne A.; Van Nes, Egbert H.; Wells, Scott A.; Janse, Jan H.

    2010-01-01

    A large number and wide variety of lake ecosystem models have been developed and published during the past four decades. We identify two challenges for making further progress in this field. One such challenge is to avoid developing more models largely following the concept of others ('reinventing the wheel'). The other challenge is to avoid focusing on only one type of model, while ignoring new and diverse approaches that have become available ('having tunnel vision'). In this paper, we aim at improving the awareness of existing models and knowledge of concurrent approaches in lake ecosystem modelling, without covering all possible model tools and avenues. First, we present a broad variety of modelling approaches. To illustrate these approaches, we give brief descriptions of rather arbitrarily selected sets of specific models. We deal with static models (steady state and regression models), complex dynamic models (CAEDYM, CE-QUAL-W2, Delft 3D-ECO, LakeMab, LakeWeb, MyLake, PCLake, PROTECH, SALMO), structurally dynamic models and minimal dynamic models. We also discuss a group of approaches that could all be classified as individual based: super-individual models (Piscator, Charisma), physiologically structured models, stage-structured models and trait-based models. We briefly mention genetic algorithms, neural networks, Kalman filters and fuzzy logic. Thereafter, we zoom in, as an in-depth example, on the multi-decadal development and application of the lake ecosystem model PCLake and related models (PCLake Metamodel, Lake Shira Model, IPH-TRIM3D-PCLake). In the discussion, we argue that while the historical development of each approach and model is understandable given its 'leading principle', there are many opportunities for combining approaches. We take the point of view that a single 'right' approach does not exist and should not be strived for. Instead, multiple modelling approaches, applied concurrently to a given problem, can help develop an integrative

  17. A multi-site approach towards integrating environmental ...

    African Journals Online (AJOL)

    A multi-site approach towards integrating environmental management in the wine ... of environmental performance key indicators, especially in water consumption ... some effluent quality improvements through better wastewater management, ...

  18. A geometric approach to integrability conditions for Riccati equations

    Directory of Open Access Journals (Sweden)

    Arturo Ramos

    2007-09-01

    Full Text Available Several instances of integrable Riccati equations are analyzed from the geometric perspective of the theory of Lie systems. This provides us a unifying viewpoint for previous approaches.

  19. [Urinary function integrity in the elderly person].

    Science.gov (United States)

    Roy, O; Rancourt, K

    1998-01-01

    How can nurses help preserve the integrity of elimination in the elderly? Further, what new perspectives must they bring to practice? First, health professionals must rid themselves of their misconceptions, especially the belief that incontinence is "normal" in the aging process. The authors provide avenues for reflection and action, with a view to arriving at a dynamic clinical practice focusing on quality of life and the well-being of the individual. In terms of new perspectives, nurses are encouraged to stop limiting themselves to assisting with personal hygiene because this deprives the client of possible recourse to a better adaptation. Nurses must no longer dispense comfort by reassuring the incontinent person that "there's no harm done". This message ignores the real-life experience associated with the problem and reinforces the idea of normality. Assessment of the client's condition must go beyond the superficial and instead target interventions that lead to a resolution. Updating the caregiver's and the client's knowledge, enhancing the nurse's role in prevention and treatment, combining various approaches to care and improving communication are good places to start.

  20. ONTOLOGY INTEGRATION APPROACHES AND ITS IMPACT ON TEXT CATEGORIZATION

    Directory of Open Access Journals (Sweden)

    Hamid Machhour

    2013-05-01

    Full Text Available This article will introduce some approaches for improving text categorization models by integrating previously imported ontologies. From the Reuters Corpus Volume I (RCV1 dataset, some categories very similar in content and related to telecommunications, Internet and computer areas were selected for models experiments. Several domain ontologies, covering these areas were built and integrated to categorization models for their improvements.

  1. Teams in Education: Creating an Integrated Approach.

    Science.gov (United States)

    Arcaro, Jerome S.

    This handbook is designed to help educational professionals develop cross-functional or departmental quality teams. Nine chapters focus on: (1) the concept of Total Quality Management (TQM) and 14 points for quality in education; (2) team goals and formation; (3) stages of successful team building; (4) the development of quality task teams; (5)…

  2. Oscillatory integrals for phase functions having certain degenerate critical points

    Institute of Scientific and Technical Information of China (English)

    Jinmyong KIM; ZHENG Quan

    2008-01-01

    The paper is concerned with oscillatory integrals for phase functions having certain de-generate critical points. Under a finite type condition of phase functions we show the estimate of oscillatory integrals of the first kind. The decay of the oscillatory integral depends on indices of the finite type, the spatial dimension and the symbol.

  3. Oscillatory integrals for phase functions having certain degenerate critical points

    Institute of Scientific and Technical Information of China (English)

    Jinmyong; KIM

    2008-01-01

    The paper is concerned with oscillatory integrals for phase functions having certain de- generate critical points. Under a finite type condition of phase functions we show the estimate of oscillatory integrals of the first kind. The decay of the oscillatory integral depends on indices of the finite type, the spatial dimension and the symbol.

  4. The Numerical Integration of Discrete Functions on a Triangular Element

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    With the application of Hammer integral formulas of a continuousfunction on a triangular element, the numerical integral formulas of some discrete functions on the element are derived by means of decomposition and recombination of base functions. Hammer integral formulas are the special examples of those of the paper.

  5. Teaching energy using an integrated science approach

    Science.gov (United States)

    Poggi, Valeria; Miceli, Cristina; Testa, Italo

    2017-01-01

    Despite its relevance to all scientific domains, the debate surrounding the teaching of energy is still open. The main point remains the problems students have in understanding some aspects of the energy concept and in applying their knowledge to the comprehension of natural phenomena. In this paper, we present a research-based interdisciplinary approach to the teaching of energy in which the first and second laws of thermodynamics were used to interpret physical, chemical and biological processes. The contents of the three disciplines (physics, chemistry, biology) were reconstructed focusing on six basic aspects of energy (forms, transfer, transformation, conservation, degradation, and entropy) and using common teaching methodologies. The module was assessed with 39 secondary school students (aged 15-16) using a 30-question research instrument and a treatment/control group methodology. Analysis of students’ learning outcomes suggests a better understanding of the energy concept, supporting the effectiveness of an interdisciplinary approach in the teaching of energy in physics and science in general. Implications for the teaching of energy are briefly discussed.

  6. Quantifying complexity in translational research: an integrated approach

    Science.gov (United States)

    Munoz, David A.; Nembhard, Harriet Black; Kraschnewski, Jennifer L.

    2014-01-01

    Purpose This article quantifies complexity in translational research. The impact of major operational steps and technical requirements (TR) is calculated with respect to their ability to accelerate moving new discoveries into clinical practice. Design/Methodology/Approach A three-phase integrated Quality Function Deployment (QFD) and Analytic Hierarchy Process (AHP) method was used to quantify complexity in translational research. A case study in obesity was used to usability. Findings Generally, the evidence generated was valuable for understanding various components in translational research. Particularly, we found that collaboration networks, multidisciplinary team capacity and community engagement are crucial for translating new discoveries into practice. Research limitations/implications As the method is mainly based on subjective opinion, some argue that the results may be biased. However, a consistency ratio is calculated and used as a guide to subjectivity. Alternatively, a larger sample may be incorporated to reduce bias. Practical implications The integrated QFD-AHP framework provides evidence that could be helpful to generate agreement, develop guidelines, allocate resources wisely, identify benchmarks and enhance collaboration among similar projects. Originality/value Current conceptual models in translational research provide little or no clue to assess complexity. The proposed method aimed to fill this gap. Additionally, the literature review includes various features that have not been explored in translational research. PMID:25417380

  7. An integrated approach to vulnerability assessment.

    Energy Technology Data Exchange (ETDEWEB)

    Tidwell, Vincent Carroll; Jurado, Sariah Ruth (University of New Mexico, Albuquerque, NM); Silva, Consuelo Juanita

    2005-03-01

    How might the quality of a city's delivered water be compromised through natural or malevolent causes? What are the consequences of a contamination event? What water utility assets are at greatest risk to compromise? Utility managers have been scrambling to find answers to these questions since the events of 9/11. However, even before this date utility mangers were concerned with the potential for system contamination through natural or accidental causes. Unfortunately, an integrated tool for assessing both the threat of attack/failure and the subsequent consequence is lacking. To help with this problem we combine Markov Latent Effects modeling for performing threat assessment calculations with the widely used pipe hydraulics/transport code, EPANET, for consequences analysis. Together information from these models defines the risk posed to the public due to natural or malevolent contamination of a water utility system. Here, this risk assessment framework is introduced and demonstrated within the context of vulnerability assessment for water distribution systems.

  8. Introducing linear functions: an alternative statistical approach

    Science.gov (United States)

    Nolan, Caroline; Herbert, Sandra

    2015-12-01

    The introduction of linear functions is the turning point where many students decide if mathematics is useful or not. This means the role of parameters and variables in linear functions could be considered to be `threshold concepts'. There is recognition that linear functions can be taught in context through the exploration of linear modelling examples, but this has its limitations. Currently, statistical data is easily attainable, and graphics or computer algebra system (CAS) calculators are common in many classrooms. The use of this technology provides ease of access to different representations of linear functions as well as the ability to fit a least-squares line for real-life data. This means these calculators could support a possible alternative approach to the introduction of linear functions. This study compares the results of an end-of-topic test for two classes of Australian middle secondary students at a regional school to determine if such an alternative approach is feasible. In this study, test questions were grouped by concept and subjected to concept by concept analysis of the means of test results of the two classes. This analysis revealed that the students following the alternative approach demonstrated greater competence with non-standard questions.

  9. Learning about the Weather through an Integrated STEM Approach

    Science.gov (United States)

    Serin, Gokhan

    2014-01-01

    Introducing concepts through an integrated science, technology, engineering and mathematics (STEM) approach can promote interest and motivation (Bennett, Lubben and Hogarth, 2007; Bybee, 2010). However, implementing such an approach effectively in a classroom setting, with relevant links, is a challenging task. Some concepts lend themselves more…

  10. Integrated approach for the intensification of heterogeneous catalytic processes.

    Science.gov (United States)

    Kiwi-Minsker, Lioubov; Crespo-Quesada, Micaela

    2011-01-01

    The integrated approach for the design of solid catalysts for process intensification is presented addressing simultaneously different levels of scale and complexity involved in the development starting from the molecular/nano-scale of the active phase optimization up to the macro-scale of the catalytic reactor design. The feasibility of this approach is demonstrated through case studies carried out in our group.

  11. Numerical Approach to Calculation of Feynman Loop Integrals

    CERN Document Server

    Yuasa, F; Kurihara, Y; Fujimoto, J; Shimizu, Y; Hamaguchi, N; de Doncker, E; Kato, K

    2011-01-01

    In this paper, we describe a numerical approach to evaluate Feynman loop integrals. In this approach the key technique is a combination of a numerical integration method and a numerical extrapolation method. Since the computation is carried out in a fully numerical way, our approach is applicable to one-, two- and multi-loop diagrams. Without any analytic treatment it can compute diagrams with not only real masses but also complex masses for the internal particles. As concrete examples we present numerical results of a scalar one-loop box integral with complex masses and two-loop planar and non-planar box integrals with masses. We discuss the quality of our numerical computation by comparisons with other methods and also propose a self consistency check.

  12. How can Design Approaches be Integrated into Entrepreneurship Education?

    DEFF Research Database (Denmark)

    Færgemann, Helle Meibom; Nørgård, Rikke Toft; Robinson, Sarah

    Questions we care about: When educating students through entrepreneurship we are interested in how can design approaches and processes be integrated into Entrepreneurship Education and what effect does this have on entrepreneurial learning? Approach: This is a conceptual paper which draws on data...... testing. Value/Originality: This paper contributes to the field of entrepreneurship education with the model that demonstrates how design thinking can be meaningfully integrated into entrepreneurship education when pedagogical approaches are questioned and reflected upon....... analysed by scholars within both the design and entrepreneurship field to understand the potential of more fully integrating the design vocabulary and processes in entrepreneurship education. Results: Overall we see a lot of potential in integrating design elements into EE, if it is done with careful...

  13. Oxidative Stress in Schizophrenia: An Integrated Approach

    Science.gov (United States)

    Bitanihirwe, Byron K.Y.; Woo, Tsung-Ung W.

    2010-01-01

    Oxidative stress has been suggested to contribute to the pathophysiology of schizophrenia. In particular, oxidative damage to lipids, proteins, and DNA as observed in schizophrenia is known to impair cell viability and function, which may subsequently account for the deteriorating course of the illness. Currently available evidence points towards an alteration in the activities of enzymatic and nonenzymatic antioxidant systems in schizophrenia. In fact, experimental models have demonstrated that oxidative stress induces behavioural and molecular anomalies strikingly similar to those observed in schizophrenia. These findings suggest that oxidative stress is intimately linked to a variety of pathophysiological processes, such as inflammation, oligodendrocyte abnormalities, mitochondrial dysfunction, hypoactive N-methyl-D-aspartate receptors and the impairment of fast-spiking gamma-aminobutyric acid interneurons.[bkyb1] Such self-sustaining mechanisms may progressively worsen producing the functional and structural consequences associated with schizophrenia. Recent clinical studies have shown antioxidant treatment to be effective in ameliorating schizophrenic symptoms. Hence, identifying viable therapeutic strategies to tackle oxidative stress and the resulting physiological disturbances provide an exciting opportunity for the treatment and ultimately prevention of schizophrenia. PMID:20974172

  14. Integrated approach in fluidized bed combustion

    Energy Technology Data Exchange (ETDEWEB)

    Bruyet, B.; Gautrin, M. [CERCHAR, Mazingarbe (France)

    1998-12-31

    Atmospheric fluidized bed technology for combustion is frequently found in different advanced power and steam generation systems, because the fluidization provides operating conditions which are favourable for pollutant control and also offers the possibility to utilise a wide range of fuels. The main objective of the study was to contribute to the development of a methodology for an easier global approach of the implementation of atmospheric fluidized bed reactors and upstream elements associated with taking into account the characteristics of fuels and sorbents, the requirements on gaseous pollutants and on solid by-products utilisation. Previous tests done in CERCHAR`s facilities were scrutinised, additional tests at laboratory and pilot level were carried out, some industrial plants were considered. Several fuels were considered (brown coals, coals, slurry,...), with a special attention to Gottelborn reference coal and Rheinbraun lignite. Experimental results and tentative conclusions viz. fuel characterization, batch fluidization set-up, 1 MW atmospheric fluidized bed pilot, ash utilisation/disposal, methodology and management of preliminary testing are presented. 12 refs., 18 figs., 13 tabs.

  15. An integral approach to investigate planetary cores

    Science.gov (United States)

    Fei, Y.

    2012-12-01

    shockwave compression to determine density, sound velocity, and melting of core materials up to liquid outer core conditions. The integration of the static and dynamic compression data provides an extensive dataset over a wide pressure and temperature range that is necessary for establishing a comprehensive model of the planetary cores, providing the best fit to the geophysical, cosmochemial, and geochemical observations.

  16. An Integrated Management Approach to Atrial Fibrillation.

    Science.gov (United States)

    Carter, Lindsey; Gardner, Martin; Magee, Kirk; Fearon, Ann; Morgulis, Inna; Doucette, Steve; Sapp, John L; Gray, Chris; Abdelwahab, Amir; Parkash, Ratika

    2016-01-25

    Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia resulting in mortality and morbidity. Gaps in oral anticoagulation and education of patients regarding AF have been identified as areas that require improvement. A before-and-after study of 433 patients with newly diagnosed AF in the 3 emergency departments in Nova Scotia from January 1, 2011 until January 31, 2014 was performed. The "before" phase underwent the usual-care pathway for AF management; the "after" phase was enrolled in a nurse-run, physician-supervised AF clinic. The primary outcome was a composite of death, cardiovascular hospitalization, and AF-related emergency department visits. A propensity analysis was performed to account for differences in baseline characteristics. A total of 185 patients were enrolled into the usual-care group, and 228 patients were enrolled in the AF clinic group. The mean age was 64±15 years and 44% were women. In a propensity-matched analysis, the primary outcome occurred in 44 (26.2%) patients in the usual-care group and 29 (17.3%) patients in the AF clinic group (odds ratio 0.71; 95% CI [0.59, 1]; P=0.049) at 12 months. Prescription of oral anticoagulation was increased in the CHADS2 ≥2 group (88.4% in the AF clinic versus 58.5% in the usual-care group, Pmanagement approach for the burgeoning population of AF may provide an overall benefit to cardiovascular morbidity and mortality. © 2016 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell.

  17. Uncertain data integration using functional dependencies

    NARCIS (Netherlands)

    Ayat, N.; Afsarmanesh, H.; Akbarinia, R.; Valduriez, P.

    2012-01-01

    Data integration systems are crucial for applications that need to provide a uniform interface to a set of autonomous and heterogeneous data sources. However, setting up a full data integration system for many application contexts, e.g. web and scientifc data management, requires significant human e

  18. Integration of the supersonic kernel function

    CSIR Research Space (South Africa)

    Van Zyl, LH

    1994-11-01

    Full Text Available The article discusses ways in which the integrals resulting from a zero-order discontinuous pressure distribution can be arranged in such a way that they can be solved by either normal quadrature or curve fitting followed by analytical integration...

  19. A Multivariate Approach to Functional Neuro Modeling

    DEFF Research Database (Denmark)

    Mørch, Niels J.S.

    1998-01-01

    This Ph.D. thesis, A Multivariate Approach to Functional Neuro Modeling, deals with the analysis and modeling of data from functional neuro imaging experiments. A multivariate dataset description is provided which facilitates efficient representation of typical datasets and, more importantly...... and overall conditions governing the functional experiment, via associated micro- and macroscopic variables. The description facilitates an efficient microscopic re-representation, as well as a handle on the link between brain and behavior; the latter is achieved by hypothesizing variations in the micro...... a generalization theoretical framework centered around measures of model generalization error. - Only few, if any, examples of the application of generalization theory to functional neuro modeling currently exist in the literature. - Exemplification of the proposed generalization theoretical framework...

  20. Pediatric Integrative Medicine Approaches to Attention Deficit Hyperactivity Disorder (ADHD

    Directory of Open Access Journals (Sweden)

    Anna Esparham

    2014-08-01

    Full Text Available Attention deficit hyperactivity disorder (ADHD is the most common neuropsychiatric disorder in children and is increasing in prevalence. There has also been a related increase in prescribing stimulant medication despite some controversy whether ADHD medication makes a lasting difference in school performance or achievement. Families who are apprehensive about side effects and with concerns for efficacy of medication pursue integrative medicine as an alternative or adjunct to pharmacologic and cognitive behavioral treatment approaches. Integrative medicine incorporates evidence-based medicine, both conventional and complementary and alternative therapies, to deliver personalized care to the patient, emphasizing diet, nutrients, gut health, and environmental influences as a means to decrease symptoms associated with chronic disorders. Pediatric integrative medicine practitioners are increasing in number throughout the United States because of improvement in patient health outcomes. However, limited funding and poor research design interfere with generalizable treatment approaches utilizing integrative medicine. The use of research designs originally intended for drugs and procedures are not suitable for many integrative medicine approaches. This article serves to highlight integrative medicine approaches in use today for children with ADHD, including dietary therapies, nutritional supplements, environmental hygiene, and neurofeedback.

  1. Estimating Function Approaches for Spatial Point Processes

    Science.gov (United States)

    Deng, Chong

    Spatial point pattern data consist of locations of events that are often of interest in biological and ecological studies. Such data are commonly viewed as a realization from a stochastic process called spatial point process. To fit a parametric spatial point process model to such data, likelihood-based methods have been widely studied. However, while maximum likelihood estimation is often too computationally intensive for Cox and cluster processes, pairwise likelihood methods such as composite likelihood, Palm likelihood usually suffer from the loss of information due to the ignorance of correlation among pairs. For many types of correlated data other than spatial point processes, when likelihood-based approaches are not desirable, estimating functions have been widely used for model fitting. In this dissertation, we explore the estimating function approaches for fitting spatial point process models. These approaches, which are based on the asymptotic optimal estimating function theories, can be used to incorporate the correlation among data and yield more efficient estimators. We conducted a series of studies to demonstrate that these estmating function approaches are good alternatives to balance the trade-off between computation complexity and estimating efficiency. First, we propose a new estimating procedure that improves the efficiency of pairwise composite likelihood method in estimating clustering parameters. Our approach combines estimating functions derived from pairwise composite likeli-hood estimation and estimating functions that account for correlations among the pairwise contributions. Our method can be used to fit a variety of parametric spatial point process models and can yield more efficient estimators for the clustering parameters than pairwise composite likelihood estimation. We demonstrate its efficacy through a simulation study and an application to the longleaf pine data. Second, we further explore the quasi-likelihood approach on fitting

  2. Towards an integrated approach to marine benthic monitoring.

    Science.gov (United States)

    Barrio Froján, Christopher R S; Cooper, Keith M; Bolam, Stefan G

    2016-03-15

    In the UK, most marine benthic monitoring is carried out in a piecemeal fashion, funded by different sectors of industry that utilise the marine environment under licence. Monitoring requirements are imposed by licence conditions, which can vary considerably between licences. The UK Government also conducts marine environmental surveys in support of its legislative commitments. The present investigation reviews these different monitoring approaches to highlight whether synergies between them could be developed into an integrated approach to marine benthic monitoring. An integrated approach would have ecological benefits, as greater consistency in sampling and analytical protocols would reduce uncertainty in the predictions of impact, and facilitate the assessment of Good Environmental Status under the Marine Strategy Framework Directive. The same approach would also be of financial benefit, as spatio-temporal duplication in sampling would be reduced, and the value of acquired data would be maximised, resulting in a more efficient and cost-effective approach.

  3. Existence Theorem for Integral and Functional Integral Equations with Discontinuous Kernels

    OpenAIRE

    2012-01-01

    Existence of extremal solutions of nonlinear discontinuous integral equations of Volterra type is proved. This result is extended herein to functional Volterra integral equations (FVIEs) and to a system of discontinuous VIEs as well.

  4. Integrated Approach of Agri-nanotechnology: Challenges and Future Trends

    Science.gov (United States)

    Mishra, Sandhya; Keswani, Chetan; Abhilash, P. C.; Fraceto, Leonardo F.; Singh, Harikesh Bahadur

    2017-01-01

    Nanotechnology representing a new frontier in modern agriculture is anticipated to become a major thrust in near future by offering potential applications. This integrating approach, i.e., agri-nanotechnology has great potential to cope with global challenges of food production/security, sustainability and climate change. However, despite the potential benefits of nanotechnology in agriculture so far, their relevance has not reached up to the field conditions. The elevating concerns about fate, transport, bioavailability, nanoparticles toxicity and inappropriateness of regulatory framework limit the complete acceptance and inclination to adopt nanotechnologies in agricultural sector. Moreover, the current research trends lack realistic approach that fail to attain comprehensive knowledge of risk assessment factors and further toxicity of nanoparticles toward agroecosystem components viz. plant, soil, soil microbiomes after their release into the environment. Hence in the present review we attempt to suggest certain key points to be addressed in the current and future agri-nanotechnology researches on the basis of recognized knowledge gaps with strong recommendation of incorporating biosynthesized nanoparticles to carry out analogous functions. In this perspective, the major points are as follows: (i) Mitigating risk assessment factors (responsible for fate, transport, behavior, bioavailability and toxicity) for alleviating the subsequent toxicity of nanoparticles. (ii) Optimizing permissible level of nanoparticles dose within the safety limits by performing dose dependent studies. (iii) Adopting realistic approach by designing the experiments in natural habitat and avoiding in vitro assays for accurate interpretation. (iv) Most importantly, translating environmental friendly and non-toxic biosynthesized nanoparticles from laboratory to field conditions for agricultural benefits. PMID:28421100

  5. Reexamination of molecular integrals arising from the Dirac equation. Analytical evaluation of molecular auxiliary functions integrals

    CERN Document Server

    Bagci, A

    2016-01-01

    The author in his previous works were presented a numerical integration method, namely, global-adaptive with the Gauss-Kronrod numerical integration extension in order to accurate calculation of molecular auxiliary functions integrals involve power functions with non-integer exponents. They are constitute elements of molecular integrals arising in Dirac equation when Slater-type orbitals with non-integer principal quantum numbers are used. Binomial series representation of power functions method, so far, is used for analytical evaluation of the molecular auxiliary function integrals however, intervals of integration cover areas beyond the condition of convergence. In the present study, analytical evaluation of these integrals is re-examined. They are expressed via prolate spheroidal coordinates. An alternative analytical approximation are derived. Slowly convergent binomial series representation formulae for power functions is investigated through nonlinear sequence transformations for the acceleration of con...

  6. The Pentabox Master Integrals with the Simplified Differential Equations approach

    CERN Document Server

    Papadopoulos, Costas G; Wever, Christopher

    2015-01-01

    We present the calculation of massless two-loop Master Integrals relevant to five-point amplitudes with one off-shell external leg and derive the complete set of planar Master Integrals with five on-mass-shell legs, that contribute to many $2\\to 3$ amplitudes of interest at the LHC, as for instance three jet production, $\\gamma, V, H +2$ jets etc., based on the Simplified Differential Equations approach.

  7. Looping probabilities of elastic chains: a path integral approach.

    Science.gov (United States)

    Cotta-Ramusino, Ludovica; Maddocks, John H

    2010-11-01

    We consider an elastic chain at thermodynamic equilibrium with a heat bath, and derive an approximation to the probability density function, or pdf, governing the relative location and orientation of the two ends of the chain. Our motivation is to exploit continuum mechanics models for the computation of DNA looping probabilities, but here we focus on explaining the novel analytical aspects in the derivation of our approximation formula. Accordingly, and for simplicity, the current presentation is limited to the illustrative case of planar configurations. A path integral formalism is adopted, and, in the standard way, the first approximation to the looping pdf is obtained from a minimal energy configuration satisfying prescribed end conditions. Then we compute an additional factor in the pdf which encompasses the contributions of quadratic fluctuations about the minimum energy configuration along with a simultaneous evaluation of the partition function. The original aspects of our analysis are twofold. First, the quadratic Lagrangian describing the fluctuations has cross-terms that are linear in first derivatives. This, seemingly small, deviation from the structure of standard path integral examples complicates the necessary analysis significantly. Nevertheless, after a nonlinear change of variable of Riccati type, we show that the correction factor to the pdf can still be evaluated in terms of the solution to an initial value problem for the linear system of Jacobi ordinary differential equations associated with the second variation. The second novel aspect of our analysis is that we show that the Hamiltonian form of these linear Jacobi equations still provides the appropriate correction term in the inextensible, unshearable limit that is commonly adopted in polymer physics models of, e.g. DNA. Prior analyses of the inextensible case have had to introduce nonlinear and nonlocal integral constraints to express conditions on the relative displacement of the end

  8. Weighted hardy type integral inequalities involving many functions

    Directory of Open Access Journals (Sweden)

    Sabir Hussain

    2012-06-01

    Full Text Available The object of this paper is to derive some new weighted Hardy type integral inequalities involving many functions and to obtain a classical weighted Hardy type inequality involving many functions.

  9. Integral representations for computing real parabolic cylinder functions

    NARCIS (Netherlands)

    Gil, A.; Segura, J.; Temme, N.M.

    2005-01-01

    Integral representations are derived for the parabolic cylinder functions U(a,x), V(a,x) and W(a,x) and their derivatives. The new integrals will be used in numerical algorithms based on quadrature. They follow from contour integrals in the complex plane, by using methods from asymptotic analysis (s

  10. Partition functions and graphs: A combinatorial approach

    CERN Document Server

    Solomon, A I; Duchamp, G; Horzela, A; Penson, K A; Solomon, Allan I.; Blasiak, Pawel; Duchamp, Gerard; Horzela, Andrzej; Penson, Karol A.

    2004-01-01

    Although symmetry methods and analysis are a necessary ingredient in every physicist's toolkit, rather less use has been made of combinatorial methods. One exception is in the realm of Statistical Physics, where the calculation of the partition function, for example, is essentially a combinatorial problem. In this talk we shall show that one approach is via the normal ordering of the second quantized operators appearing in the partition function. This in turn leads to a combinatorial graphical description, giving essentially Feynman-type graphs associated with the theory. We illustrate this methodology by the explicit calculation of two model examples, the free boson gas and a superfluid boson model. We show how the calculation of partition functions can be facilitated by knowledge of the combinatorics of the boson normal ordering problem; this naturally gives rise to the Bell numbers of combinatorics. The associated graphical representation of these numbers gives a perturbation expansion in terms of a sequen...

  11. Integrated Transport Planning Framework Involving Combined Utility Regret Approach

    DEFF Research Database (Denmark)

    Wang, Yang; Monzon, Andres; Di Ciommo, Floridea;

    2014-01-01

    Sustainable transport planning requires an integrated approach involving strategic planning, impact analysis, and multicriteria evaluation. This study aimed at relaxing the utility-based decision-making assumption by newly embedding anticipated-regret and combined utility regret decision mechanisms...... in a framework for integrated transport planning. The framework consisted of a two-round Delphi survey, integrated land use and transport model for Madrid, and multicriteria analysis. Results show that (a) the regret-based ranking has a similar mean but larger variance than the utility-based ranking does, (b...

  12. An Integrated Approach for Entry Mission Design and Flight Simulations

    Science.gov (United States)

    Lu, Ping; Rao, Prabhakara

    2004-01-01

    An integrated approach for entry trajectory design, guidance, and simulation is proposed. The key ingredients for this approach are an on-line 3 degree-of-freedom entry trajectory planning algorithm and the entry guidance algorithm that generates the guidance gains automatically. When fully developed, such a tool could enable end-bend entry mission design and simulations in 3DOF and 6DOF mode from de-orbit burn to the TAEM interface and beyond, all in one key stroke. Some preliminary examples of such a capability are presented in this paper that demonstrate the potential of this type of integrated environment.

  13. An integrated lean-methods approach to hospital facilities redesign.

    Science.gov (United States)

    Nicholas, John

    2012-01-01

    Lean production methods for eliminating waste and improving processes in manufacturing are now being applied in healthcare. As the author shows, the methods are appropriate for redesigning hospital facilities. When used in an integrated manner and employing teams of mostly clinicians, the methods produce facility designs that are custom-fit to patient needs and caregiver work processes, and reduce operational costs. The author reviews lean methods and an approach for integrating them in the redesign of hospital facilities. A case example of the redesign of an emergency department shows the feasibility and benefits of the approach.

  14. Integration of approaches in David Wake's model-taxon research platform for evolutionary morphology.

    Science.gov (United States)

    Griesemer, James

    2013-12-01

    What gets integrated in integrative scientific practices has been a topic of much discussion. Traditional views focus on theories and explanations, with ideas of reduction and unification dominating the conversation. More recent ideas focus on disciplines, fields, or specialties; models, mechanisms, or methods; phenomena, problems. How integration works looks different on each of these views since the objects of integration are ontologically and epistemically various: statements, boundary conditions, practices, protocols, methods, variables, parameters, domains, laboratories, and questions all have their own structures, functions and logics. I focus on one particular kind of scientific practice, integration of "approaches" in the context of a research system operating on a special kind of "platform." Rather than trace a network of interactions among people, practices, and theoretical entities to be integrated, in this essay I focus on the work of a single investigator, David Wake. I describe Wake's practice of integrative evolutionary biology and how his integration of approaches among biological specialties worked in tandem with his development of the salamanders as a model taxon, which he used as a platform to solve, re-work and update problems that would not have been solved so well by non-integrative approaches. The larger goal of the project to which this paper contributes is a counter-narrative to the story of 20th century life sciences as the rise and march of the model organisms and decline of natural history.

  15. Baker-Akhiezer functions and generalised Macdonald-Mehta integrals

    Science.gov (United States)

    Feigin, M. V.; Hallnäs, M. A.; Veselov, A. P.

    2013-05-01

    For the rational Baker-Akhiezer functions associated with special arrangements of hyperplanes with multiplicities we establish an integral identity, which may be viewed as a generalisation of the self-duality property of the usual Gaussian function with respect to the Fourier transformation. We show that the value of properly normalised Baker-Akhiezer function at the origin can be given by an integral of Macdonald-Mehta type and explicitly compute these integrals for all known Baker-Akhiezer arrangements. We use the Dotsenko-Fateev integrals to extend this calculation to all deformed root systems, related to the non-exceptional basic classical Lie superalgebras.

  16. An integral estimate of Bessel function and its application

    Institute of Scientific and Technical Information of China (English)

    DING Yong; LI Ran

    2008-01-01

    In this paper the authors give a new integral estimate of the Bessel function, which parameterized Marcinkiewicz integral μΩρ with variable kernels is of type (2, 2), where the kernel function Ω does not have any smoothness on the unit sphere in Rn.

  17. Some integrals involving generalized k-Struve functions

    Directory of Open Access Journals (Sweden)

    Kottakkaran Sooppy Nisar

    2017-03-01

    Full Text Available The close form of some integrals involving recently developed generalized k-Struve functions is obtained. The outcome of these integrations is expressed in terms of generalized Wright functions. Several special cases are deduced which lead to some known results.

  18. An Integrated Approach for Creating Service-Based Interactive Applications

    Science.gov (United States)

    Feldmann, Marius; Janeiro, Jordan; Nestler, Tobias; Hübsch, Gerald; Jugel, Uwe; Preussner, André; Schill, Alexander

    While the implementation of business logic and business processes based on service-oriented architectures is well-understood and covered by existing development approaches, integrated concepts that empower users to exploit the Internet of Services to create complex interactive applications are missing. In this paper, we present an integrated approach that fills this gap. Our approach builds upon service annotations that add meta-information related to user interface generation, service dependencies, and service composition to existing service descriptions. Services can be composed visually to complex interactive applications based on these annotations without the need to write any code. The application code is generated completely from the service composition description. Our approach is able to support heterogeneous target environments ranging from client/server architectures to mobile platforms.

  19. An Empirical, Functional approach to Depth Damages

    Directory of Open Access Journals (Sweden)

    Lehman Will

    2016-01-01

    Full Text Available In order to compute direct damages to structures and contents, the United States Army Corps of Engineers (USACE has traditionally relied on relationships that define damage for a given depth. These relationships are described using paired data relationships of depth and damage. Generally, the curves utilized are based on an Elicitation of Experts (EoE. This paper will present an alternative methodology which takes empirical data of damage and depth, stratified by building classifications, and use Non Linear Least Squares Estimation to fit a parameterized function to compute depth-damage estimates. The general function will be described, and the parameters will be discussed. Parameters include foundation height, ground elevation, percent damages below ground, number of stories, height of stories, maximum damage as a percent, and the beginning elevation for damage. The advantages of this approach include the ability to utilize empirical data, and the ability to change parameters based on building practices across the world. Additionally, the paper will illustrate a bootstrapping approach to the empirical data to assist in describing confidence limits around the parameterized functional depth damage relationship. A Figure (Figure 1 is provided to illustrate the output of the process.

  20. Libcint: An efficient general integral library for Gaussian basis functions

    CERN Document Server

    Sun, Qiming

    2014-01-01

    An efficient integral library Libcint was designed to automatically implement general integrals for Gaussian-type scalar and spinor basis functions. The library can handle arbitrary integral expressions on top of $\\mathbf{p}$, $\\mathbf{r}$ and $\\sigma$ operators with one-electron overlap and nuclear attraction, two-electron Coulomb and Gaunt operators. Using a symbolic algebra tool, new integrals are derived and translated to C code programmatically. The generated integrals can be used in various types of molecular properties. In the present work, we computed the analytical gradients and NMR shielding constants at both non-relativistic and four-component relativistic Hartree-Fock level to demonstrate the capability of the integral library. Due to the use of kinetically balanced basis and gauge including atomic orbitals, the relativistic analytical gradients and shielding constants requires the integral library to handle the fifth-order electron repulsion integral derivatives. The generality of the integral li...

  1. Toward the Integration of Traditional and Agile Approaches

    Directory of Open Access Journals (Sweden)

    Hung-Fu Chang

    2013-03-01

    Full Text Available The agile approach uses continuous delivery, instead of distinct procedure, to work closer with customers and to respond faster requirement changes. All of these are against the traditional plan driven approach. Due to agile method’s characteristics and its success in the real world practices, a number of discussions regarding the differences between agile and traditional approaches emerged recently and many studies intended to integrate both methods to synthesize the benefits from these two sides. However, this type of research often concludes from observations of a development activity or surveys after a project. To provide a more objective supportive evidence of comparing these two approaches, our research analyzes the source codes, logs, and notes. We argue that the agile and traditional approaches share common characteristics, which can be considered as the glue for integrating both methods. In our study, we collect all the submissions from the version control repository, and meeting notes and discussions. By applying our suggested analysis method, we illustrate the shared properties between agile and traditional approaches; thus, different development phases, like implementation and test, can still be identified in agile development history. This result not only provides a positive result for our hypothesis but also offers a suggestion for a better integration.

  2. Building Safer Communities: The Integrated Community Safety Approach

    Energy Technology Data Exchange (ETDEWEB)

    Fawcett, Ricky Lee; Kerr, Thomas A; Jordan, Steven Albert

    2001-03-01

    This paper discusses an integrated community safety approach to creating safer communities. It defines community broadly to include two categories of community members: “industry” and “neighbors.” Potential community members within the “industry” category include facilities, government/regulators, customers, stockholders, and suppliers. Within the “neighbors” category are towns, cities, counties, states; people/commodity flow systems; news media and special interest groups; environment; and families of employees. Each of these potential community members and its characteristics are discussed. The integrated community safety approach consists of three major activities: (1) define the boundaries of the community; (2) facilitate the sense of community; and (3) address the needs of the community. Defining the boundaries of the community includes determining the geographical and social boundaries; this is accomplished through conducting a hazard analysis and community involvement to identify all of the community members. Facilitating the sense of community includes conducting a capability/needs assessment and continuing community involvement to identify the issues and concerns of community members. Addressing the needs of the community involves master planning to consider safety issues in all community development actions and continuing community education and involvement. The integrated community safety approach is a workable approach for existing industries and their neighbors as well as new projects that industries and their neighbors might be considering. By using this socio-technical approach to integrating industry and all of its neighbors into a safer community, the integrated community safety approach will better assure the viability and safety of industry and its neighbors while maintaining or improving the overall quality of life.

  3. Calculation of plantar pressure time integral, an alternative approach.

    Science.gov (United States)

    Melai, Tom; IJzerman, T Herman; Schaper, Nicolaas C; de Lange, Ton L H; Willems, Paul J B; Meijer, Kenneth; Lieverse, Aloysius G; Savelberg, Hans H C M

    2011-07-01

    In plantar pressure measurement, both peak pressure and pressure time integral are used as variables to assess plantar loading. However, pressure time integral shows a high concordance with peak pressure. Many researchers and clinicians use Novel software (Novel GmbH Inc., Munich, Germany) that calculates this variable as the summation of the products of peak pressure and duration per time sample, which is not a genuine integral of pressure over time. Therefore, an alternative calculation method was introduced. The aim of this study was to explore the relevance of this alternative method, in different populations. Plantar pressure variables were measured in 76 people with diabetic polyneuropathy, 33 diabetic controls without polyneuropathy and 19 healthy subjects. Peak pressure and pressure time integral were obtained using Novel software. The quotient of the genuine force time integral over contact area was obtained as the alternative pressure time integral calculation. This new alternative method correlated less with peak pressure than the pressure time integral as calculated by Novel. The two methods differed significantly and these differences varied between the foot sole areas and between groups. The largest differences were found under the metatarsal heads in the group with diabetic polyneuropathy. From a theoretical perspective, the alternative approach provides a more valid calculation of the pressure time integral. In addition, this study showed that the alternative calculation is of added value, along peak pressure calculation, to interpret adapted plantar pressures patterns in particular in patients at risk for foot ulceration. Copyright © 2011 Elsevier B.V. All rights reserved.

  4. Alkane production from biomass: chemo-, bio- and integrated catalytic approaches.

    Science.gov (United States)

    Deneyer, Aron; Renders, Tom; Van Aelst, Joost; Van den Bosch, Sander; Gabriëls, Dries; Sels, Bert F

    2015-12-01

    Linear, branched and cyclic alkanes are important intermediates and end products of the chemical industry and are nowadays mainly obtained from fossil resources. In search for alternatives, biomass feedstocks are often presented as a renewable carbon source for the production of fuels, chemicals and materials. However, providing a complete market for all these applications seems unrealistic due to both financial and logistic issues. Despite the very large scale of current alkane-based fuel applications, biomass definitely has the potential to offer a partial solution to the fuel business. For the smaller market of chemicals and materials, a transition to biomass as main carbon source is more realistic and even probably unavoidable in the long term. The appropriate use and further development of integrated chemo- and biotechnological (catalytic) process strategies will be crucial to successfully accomplish this petro-to-bio feedstock transition. Furthermore, a selection of the most promising technologies from the available chemo- and biocatalytic tool box is presented. New opportunities will certainly arise when multidisciplinary approaches are further explored in the future. In an attempt to select the most appropriate biomass sources for each specific alkane-based application, a diagram inspired by van Krevelen is applied, taking into account both the C-number and the relative functionality of the product molecules.

  5. A unified approach to several results involving integrals of multifunctions

    OpenAIRE

    Balder, E.J.

    2001-01-01

    A well-known equivalence of randomization result of Wald and Wolfowitz states that any Young measure can be regarded as a probability measure on the set of all measurable functions. Here we give a sucient condition for the Young measure to be equivalent to a probability measure on the set of all integrable selectors of a given multifunction. In this way, Aumann's identity for integrals of multifunctions can be interpreted in a novel fashion. By additionally applying a fundamental result from ...

  6. Integrating out heavy particles with functional methods: a simplified framework

    CERN Document Server

    Fuentes-Martin, Javier; Ruiz-Femenia, Pedro

    2016-01-01

    We present a systematic procedure to obtain the one-loop low-energy effective Lagrangian resulting from integrating out the heavy fields of a given ultraviolet theory. We show that the matching coefficients are determined entirely by the hard region of the functional determinant involving the heavy fields. This represents an important simplification with respect the conventional matching approach, where the full and effective theory contributions have to be computed separately and a cancellation of the infrared divergent parts has to take place. We illustrate the method with a descriptive toy model and with an extension of the Standard Model with a heavy real scalar triplet. A comparison with other schemes that have been put forward recently is also provided.

  7. Overlap between empathy, teamwork and integrative approach to patient care.

    Science.gov (United States)

    Hojat, Mohammadreza; Bianco, Joseph A; Mann, Douglas; Massello, David; Calabrese, Leonard H

    2014-10-14

    Abstract Background: Empathy, teamwork and an integrative approach to patient care share common denominators such as interpersonal skills and understanding patients' concerns. Thus, a significant overlap among measures of empathy, teamwork and integrative approach to patient care is expected. Aim: This study examined the magnitude of overlap (shared variance) among three measures of empathy, teamwork and an integrative approach to patient care. Methods: Three-hundred seventy-three medical students completed the Jefferson Scale of Empathy (JSE), the Jefferson Scale of Attitudes toward Physician-Nurse Collaboration (JSAPNC) and Integrative Patient Care (IPC). Results: Significant overlaps were found among the three measures (p < 0.01), ranging from 13% (r = 0.36), between JSAPNC and IPC, to 18% (r = 0.42), between JSE and JSAPNC, and 30% (r = 0.55) between JSE and IPC for the total sample. Pattern of findings was similar for men and women. In a multiple regression model, a significant multiple correlation (R = 0.60, p < 0.01) was obtained in correlating scores on the JSE with the JSAPNC, and IPC scores, controlling for gender effect (men = 0 and women = 1). Conclusions: The significant links between empathy, teamwork and IPC support the common denominator assumption. The findings that IPC shares common variance with empathy and teamwork have implications for medical education curriculum, suggesting that implementation of integrative patient care can improve empathic engagement in patient care and orientation toward teamwork.

  8. Understanding integrated care: a comprehensive conceptual framework based on the integrative functions of primary care

    Directory of Open Access Journals (Sweden)

    Pim P. Valentijn

    2013-03-01

    Full Text Available Introduction: Primary care has a central role in integrating care within a health system. However, conceptual ambiguity regarding integrated care hampers a systematic understanding. This paper proposes a conceptual framework that combines the concepts of primary care and integrated care, in order to understand the complexity of integrated care.Methods:  The search method involved a combination of electronic database searches, hand searches of reference lists (snowball method and contacting researchers in the field. The process of synthesizing the literature was iterative, to relate the concepts of primary care and integrated care. First, we identified the general principles of primary care and integrated care. Second, we connected the dimensions of integrated care and the principles of primary care. Finally, to improve content validity we held several meetings with researchers in the field to develop and refine our conceptual framework.Results: The conceptual framework combines the functions of primary care with the dimensions of integrated care. Person-focused and population-based care serve as guiding principles for achieving integration across the care continuum. Integration plays complementary roles on the micro (clinical integration, meso (professional and organisational integration and macro (system integration level. Functional and normative integration ensure connectivity between the levels.Discussion:  The presented conceptual framework is a first step to achieve a better understanding of the inter-relationships among the dimensions of integrated care from a primary care perspective.

  9. Self-consistent Green's function approaches

    CERN Document Server

    Barbieri, Carlo

    2016-01-01

    We present the fundamental techniques and working equations of many-body Green's function theory for calculating ground state properties and the spectral strength. Green's function methods closely relate to other polynomial scaling approaches discussed in chapters~8 and ~10. However, here we aim directly at a global view of the many-fermion structure. We derive the working equations for calculating many-body propagators, using both the Algebraic Diagrammatic Construction technique and the self-consistent formalism at finite temperature. Their implementation is discussed, as well as the the inclusion of three-nucleon interactions. The self-consistency feature is essential to guarantee thermodynamic consistency. The paring and neutron matter models introduced in previous chapters are solved and compared with the other methods in this book.

  10. Distribution function approach to redshift space distortions

    CERN Document Server

    Seljak, Uros

    2011-01-01

    We develop a phase space distribution function approach to redshift space distortions (RSD), in which the redshift space density can be written as a sum over velocity moments of the distribution function. These moments are density weighted and their lowest orders are density, momentum density, and stress energy density. The series expansion is convergent on large scales. We perform an expansion of these velocity moments into helicity modes, which are eigenmodes under rotation around the axis of Fourier mode direction, generalizing the scalar, vector, tensor decomposition of perturbations to an arbitrary order. We show that only equal helicity moments correlate and derive the angular dependence of the individual contributions to the redshift space power spectrum in terms of angle mu between wave vector and line of sight. We show that the dominant term of mu^2 dependence on large scales is the cross-correlation between the density and scalar part of momentum density, which can be related to the time derivative ...

  11. Teaching Service Modelling to a Mixed Class: An Integrated Approach

    Science.gov (United States)

    Deng, Jeremiah D.; Purvis, Martin K.

    2015-01-01

    Service modelling has become an increasingly important area in today's telecommunications and information systems practice. We have adapted a Network Design course in order to teach service modelling to a mixed class of both the telecommunication engineering and information systems backgrounds. An integrated approach engaging mathematics teaching…

  12. Helping Abused and Traumatized Children: Integrating Directive and Nondirective Approaches

    Science.gov (United States)

    Gil, Eliana

    2006-01-01

    Presenting an integrative model for treating traumatized children, this book combines play, art, and other expressive therapies with ideas and strategies drawn from cognitive-behavioral and family therapy. Eliana Gil demonstrates how to tailor treatment to the needs of each child by using both directive and nondirective approaches. Throughout,…

  13. An Integrated Approach to Disability Policy Development, Implementation, and Evaluation

    Science.gov (United States)

    Shogren, Karrie A.; Luckasson, Ruth; Schalock, Robert L.

    2017-01-01

    This article provides a framework for an integrated approach to disability policy development, implementation, and evaluation. The article discusses how a framework that combines systems thinking and valued outcomes can be used by coalition partners across ecological systems to implement disability policy, promote the effective use of resources,…

  14. Integration of Task-Based Approaches in a TESOL Course

    Science.gov (United States)

    Chien, Chin-Wen

    2014-01-01

    Under task-based language teaching (TBLT), language learners engage in purposeful, problem-oriented, and outcome-driven tasks that are comparable to real-world activities. This qualitative case study discusses the integration of a task-based approach into a TESOL course in a language teacher education program in Taiwan with regard to 39…

  15. Strategic competence management in global service networks: An integrated approach

    OpenAIRE

    Faix, Axel; Budde, Lukas; Friedli, Thomas

    2015-01-01

    The paper is based on an industry project in the pharmaceutical industry and describes a holistic approach to integrate competence management, capacity planning and strategic forecasting in the field of service operations in a global service network. Goal of the paper is to introduce a methodology combining operations and strategic management.

  16. Integrated Approach to Diagnosis of Associated Occupational Asthma and Rhinitis

    Directory of Open Access Journals (Sweden)

    Sébastien Nguyen

    2012-01-01

    Full Text Available Patients with coexisting work-related rhinitis and asthma would benefit from an adequate and simultaneous recognition of both diseases. The present case illustrates the advantages and importance of using an integrated approach to confirm a diagnosis of occupational rhinitis (OR and occupational asthma (OA.

  17. Child Psychotherapy, Child Analysis, and Medication: A Flexible, Integrative Approach.

    Science.gov (United States)

    Whitman, Laura

    2015-01-01

    For children with moderate to severe emotional or behavioral problems, the current approach in child psychiatry is to make an assessment for the use of both psychotherapy and medication. This paper describes integration of antidepressants and stimulants with psychoanalytically oriented techniques.

  18. An Integrated Approach to Teaching Literature in an EFL Classroom

    Science.gov (United States)

    Yimwilai, Supaporn

    2015-01-01

    This research studied the effectiveness of the integrated approach in English as a Foreign Language (EFL) classrooms and how it related to students' 1) achievements, 2) critical thinking skills, and 3) attitudes toward reading literature. To ensure that the results were accurate and reliable, the experiment was conducted in two different regions.…

  19. Ontology Integration Approaches and its Impact on Text Categorization

    Directory of Open Access Journals (Sweden)

    Hamid Machhour

    2013-06-01

    Full Text Available This article will introduce some approaches for improving text categorization models by integratingpreviously imported ontologies. From the Reuters Corpus Volume I (RCV1 dataset, some categories verysimilar in content and related to telecommunications, Internet and computer areas were selected for modelsexperiments. Several domain ontologies, covering these areas were built and integrated to categorizationmodels for their improvements.

  20. The NASA Science Internet: An integrated approach to networking

    Science.gov (United States)

    Rounds, Fred

    1991-01-01

    An integrated approach to building a networking infrastructure is an absolute necessity for meeting the multidisciplinary science networking requirements of the Office of Space Science and Applications (OSSA) science community. These networking requirements include communication connectivity between computational resources, databases, and library systems, as well as to other scientists and researchers around the world. A consolidated networking approach allows strategic use of the existing science networking within the Federal government, and it provides networking capability that takes into consideration national and international trends towards multivendor and multiprotocol service. It also offers a practical vehicle for optimizing costs and maximizing performance. Finally, and perhaps most important to the development of high speed computing is that an integrated network constitutes a focus for phasing to the National Research and Education Network (NREN). The NASA Science Internet (NSI) program, established in mid 1988, is structured to provide just such an integrated network. A description of the NSI is presented.

  1. Hybrid function method for solving Fredholm and Volterra integral equations of the second kind

    Science.gov (United States)

    Hsiao, Chun-Hui

    2009-08-01

    Numerical solutions of Fredholm and Volterra integral equations of the second kind via hybrid functions, are proposed in this paper. Based upon some useful properties of hybrid functions, integration of the cross product, a special product matrix and a related coefficient matrix with optimal order, are applied to solve these integral equations. The main characteristic of this technique is to convert an integral equation into an algebraic; hence, the solution procedures are either reduced or simplified accordingly. The advantages of hybrid functions are that the values of n and m are adjustable as well as being able to yield more accurate numerical solutions than the piecewise constant orthogonal function, for the solutions of integral equations. We propose that the available optimal values of n and m can minimize the relative errors of the numerical solutions. The high accuracy and the wide applicability of the hybrid function approach will be demonstrated with numerical examples. The hybrid function method is superior to other piecewise constant orthogonal functions [W.F. Blyth, R.L. May, P. Widyaningsih, Volterra integral equations solved in Fredholm form using Walsh functions, Anziam J. 45 (E) (2004) C269-C282; M.H. Reihani, Z. Abadi, Rationalized Haar functions method for solving Fredholm and Volterra integral equations, J. Comp. Appl. Math. 200 (2007) 12-20] for these problems.

  2. Integrating radiology vertically into an undergraduate medical education curriculum: a triphasic integration approach

    Directory of Open Access Journals (Sweden)

    Al Qahtani F

    2014-06-01

    Full Text Available Fahd Al Qahtani,1 Adel Abdelaziz2,31Radiology Department, Faculty of Medicine, Al-Baha University, Al-Baha, Saudi Arabia; 2Medical Education Development Unit, Faculty of Medicine, Al-Baha University, Al-Baha, Saudi Arabia; 3Medical Education Department, Faculty of Medicine, Suez Canal University, Ismailia, EgyptAbstract: Fulfilling the goal of integrating radiology into undergraduate medical curricula is a real challenge due to the enduring faith assuming that traditional medical disciplines are worthy of consuming the available study time. In this manner, radiology is addressed occasionally and with relevance to these traditional disciplines. In Al-Baha University Faculty of Medicine, Al-Baha, Saudi Arabia, efforts have been made to integrate radiology vertically and in a structured manner into the undergraduate curriculum from the first year to the sixth year. For achieving convenient integration of radiology, a triphasic approach to integration is adopted. This approach consists of the integration of radiology foundations into the basic sciences phase, development of a distinct 4-week module in year 4, and finally, integration of clinical applications of radiology in the clinical phase modules. Feedback of students and inferences obtained through assessment and program evaluation are in favor of this approach to integration. Minor reform and some improvement related to time allocated and content balancing are still indicated.Keywords: radiology foundations, radiology module, students assessment

  3. Integrated Fluency Instruction: Three Approaches for Working with Struggling Readers

    Directory of Open Access Journals (Sweden)

    Melanie KUHN

    2014-10-01

    Full Text Available Effective fluency instruction should focus on reading with understanding, rather than simply reading quickly or expressively. This article outlines three research-based instructional approaches that assist students in developing accurate, automatic word recognition and prosody; at the same time, they ensure learners attend to the text’s meaning as they read. All three approaches integrate instructional principles known to improve reading fluency (modeling, scaffolding, repetition, and extensive opportunity for the reading of connected text. They are also clear and easy-to-implement and have proven successful with struggling readers. As a result, these approaches contribute to learners’ reading success both within and outside of the classroom.

  4. The space of Henstock integrable functions of two variables

    Directory of Open Access Journals (Sweden)

    Krzysztof Ostaszewski

    1988-01-01

    Full Text Available We consider the space of Henstock integrable functions of two variables. Equipped with the Alexiewicz norm the space is proved to be barrelled. We give a partial description of its dual. We show by an example that the dual can't be described in a manner analogous to the one-dimensional case, since in two variables there exist functions whose distributional partials are measures and which are not multipliers for Henstock integrable functions.

  5. Object-oriented models of functionally integrated computer systems

    OpenAIRE

    Kaasbøll, Jens

    1994-01-01

    Functional integration is the compatibility between the structure, culture and competence of an organization and its computer systems, specifically the availability of data and functionality and the consistency of user interfaces. Many people use more than one computer program in their work, and they experience problems relating to functional integration. Various solutions can be considered for different tasks and technology; e.g. to design a common userinterface shell for several application...

  6. An Integrated Approach to Flexible Modelling and Animated Simulation

    Institute of Scientific and Technical Information of China (English)

    Li Shuliang; Wu Zhenye

    1994-01-01

    Based on the software support of SIMAN/CINEMA, this paper presents an integrated approach to flexible modelling and simulation with animation. The methodology provides a structured way of integrating mathematical and logical model, statistical experinentation, and statistical analysis with computer animation. Within this methodology, an animated simulation study is separated into six different activities: simulation objectives identification , system model development, simulation experiment specification, animation layout construction, real-time simulation and animation run, and output data analysis. These six activities are objectives driven, relatively independent, and integrate through software organization and simulation files. The key ideas behind this methodology are objectives orientation, modelling flexibility,simulation and animation integration, and application tailorability. Though the methodology is closely related to SIMAN/CINEMA, it can be extended to other software environments.

  7. Integral and Series Representations of Riemann's Zeta Function and Dirichlet's Eta Function and a Medley of Related Results

    Directory of Open Access Journals (Sweden)

    Michael S. Milgram

    2013-01-01

    Full Text Available Contour integral representations of Riemann's Zeta function and Dirichlet's Eta (alternating Zeta function are presented and investigated. These representations flow naturally from methods developed in the 1800s, but somehow they do not appear in the standard reference summaries, textbooks, or literature. Using these representations as a basis, alternate derivations of known series and integral representations for the Zeta and Eta function are obtained on a unified basis that differs from the textbook approach, and results are developed that appear to be new.

  8. Integrals of Lagrange functions and sum rules

    Energy Technology Data Exchange (ETDEWEB)

    Baye, Daniel, E-mail: dbaye@ulb.ac.be [Physique Quantique, CP 165/82, Universite Libre de Bruxelles, B 1050 Bruxelles (Belgium); Physique Nucleaire Theorique et Physique Mathematique, CP 229, Universite Libre de Bruxelles, B 1050 Bruxelles (Belgium)

    2011-09-30

    Exact values are derived for some matrix elements of Lagrange functions, i.e. orthonormal cardinal functions, constructed from orthogonal polynomials. They are obtained with exact Gauss quadratures supplemented by corrections. In the particular case of Lagrange-Laguerre and shifted Lagrange-Jacobi functions, sum rules provide exact values for matrix elements of 1/x and 1/x{sup 2} as well as for the kinetic energy. From these expressions, new sum rules involving Laguerre and shifted Jacobi zeros and weights are derived. (paper)

  9. Science of Integrated Approaches to Natural Resources Management

    Science.gov (United States)

    Tengberg, Anna; Valencia, Sandra

    2017-04-01

    To meet multiple environmental objectives, integrated programming is becoming increasingly important for the Global Environmental Facility (GEF), the financial mechanism of the multilateral environmental agreements, including the United Nations Convention to Combat Desertification (UNCCD). Integration of multiple environmental, social and economic objectives also contributes to the achievement of the Sustainable Development Goals (SDGs) in a timely and cost-effective way. However, integration is often not well defined. This paper therefore focuses on identifying key aspects of integration and assessing their implementation in natural resources management (NRM) projects. To that end, we draw on systems thinking literature, and carry out an analysis of a random sample of GEF integrated projects and in-depth case studies demonstrating lessons learned and good practices in addressing land degradation and other NRM challenges. We identify numerous challenges and opportunities of integrated approaches that need to be addressed in order to maximise the catalytic impact of the GEF during problem diagnosis, project design, implementation and governance. We highlight the need for projects to identify clearer system boundaries and main feedback mechanisms within those boundaries, in order to effectively address drivers of environmental change. We propose a theory of change for Integrated Natural Resources Management (INRM) projects, where short-term environmental and socio-economic benefits will first accrue at the local level. Implementation of improved INRM technologies and practices at the local level can be extended through spatial planning, strengthening of innovation systems, and financing and incentive mechanisms at the watershed and/or landscape/seascape level to sustain and enhance ecosystem services at larger scales and longer time spans. We conclude that the evolving scientific understanding of factors influencing social, technical and institutional innovations and

  10. Correlation Functions for Lattice Integrable Models

    Directory of Open Access Journals (Sweden)

    F. Smirnov

    2008-01-01

    Full Text Available In this lectures I consider the problem of calculating the correlation functions for XXZ spin chain. First, I explain in details the free fermion case. Then I show that for generic coupling constant the fermionic operators acting on the space of quasi-local fields can be introduced. In the basis generated by these fermionic operators the correlation functions are given by determinants as in the free fermion case. 

  11. Functional Integrity of Some Class of Multi-Agent Systems

    Directory of Open Access Journals (Sweden)

    Krzysztof Cetnarowicz

    1999-01-01

    Full Text Available Multi-agent systems have many advantages and give numerous new possibilities in creation of information systems. However many problems related to functioning of the systems are still unsolved. Functional integrity of multi-agents systems belongs to such problems. Functional integrity of multi-agent systems may be defined in general as preservation of basic functions of the system during its functioning. Functional integrity may be analyzed from the point of view of different functions of the system (the functions that should be preserved and also from the point of view of various factors that may influence the loss or preservation of functional integrity of the system. The paper deals with examination of functional integrity of multi-agent system depending upon number of agents (global and of particular types. During system work, agents generate agents of the same or different type that depend on their possibilities and system needs. The process performed without use of appropriate control mechanisms may lead to excessive (blocking of the system or too little number of agents and even lack of agents (disappearance of the functions of a system that are performed by agents of a certain type. A proposal of functional integrity phenomenon analysis of multi-agent systems that is related to the number of agents in their population and a proposal of mechanisms that enable maintenance of functional integrity, in particular a concept of the so-called ``free agents'' have been presented in the paper. Consideration has been carried out on the basis of simulation examination of some class of multi-agent systems. Results of simulation of proposed solutions have been included in the work.

  12. Posterior Approach to Kidney Dissection: An Old Surgical Approach for Integrated Medical Curricula

    Science.gov (United States)

    Daly, Frank J.; Bolender, David L.; Jain, Deepali; Uyeda, Sheryl; Hoagland, Todd M.

    2015-01-01

    Integrated medical curricular changes are altering the historical regional anatomy approach to abdominal dissection. The renal system is linked physiologically and biochemically to the cardiovascular and respiratory systems; yet, anatomists often approach the urinary system as part of the abdomen and pelvic regions. As part of an integrated…

  13. Posterior Approach to Kidney Dissection: An Old Surgical Approach for Integrated Medical Curricula

    Science.gov (United States)

    Daly, Frank J.; Bolender, David L.; Jain, Deepali; Uyeda, Sheryl; Hoagland, Todd M.

    2015-01-01

    Integrated medical curricular changes are altering the historical regional anatomy approach to abdominal dissection. The renal system is linked physiologically and biochemically to the cardiovascular and respiratory systems; yet, anatomists often approach the urinary system as part of the abdomen and pelvic regions. As part of an integrated…

  14. Mediterranean Storms: An Integrated Approach of Risk Management

    Science.gov (United States)

    Karageorgou, H.; Riza, E.; Linos, A.; Papanikolaou, D.

    2010-09-01

    Disaster by UN definition is "a serious disruption of the functioning of a community or a society, involving widespread human, material, economic, or environmental losses and impacts, which exceeds the ability of the affected community or society to cope using only its own resources". Mediterranean storms induce flash floods caused by excessive amounts of rainfall within a short lasting period of time. The intensity and duration of precipitation, region geomorphology, urbanization and different governmental emergency management structures trigger different consequences between Mediterranean countries. The integrated approach in management of storm risk represents a holistic perspective including interactions between government, science and technology institutions, developing agencies, private sector, NGOs and public. Local authorities and national government are responsible for the design, preparation and decision on storm risk management policies and strategies considering scientific risk identifying, assessing and understanding. Efficient governance management requires satisfied response to early warning systems, functionality of the affected systems upon which society depends and appropriate focus on variable interest, beliefs, values and ideologies between social groups. Also an appropriate balancing of benefits and costs in an efficient and equitable manner is important for the governance risk management. Natural sciences in corporation with the engineering science have developed effective early prediction, warning and monitoring systems on storm and flood risk. The health sciences use prediction systems for health related hazards and consequences and the social sciences research estimates the human resilience during disasters and the factors which affect and determine the human behavior. Also social sciences survey the response of public to early warning messages, the appropriate communicative methods to distributing messages and mechanisms to improve public

  15. Generalized fractional integration of the \\overline{H}-function

    Directory of Open Access Journals (Sweden)

    Praveen Agarwal

    2012-11-01

    Full Text Available A significantly large number of earlier works on the subject of fractional calculus give interesting account of the theory and applications of fractional calculus operators in many different areas of mathematical analysis (such as ordinary and partial differential equations, integral equations, special functions, summation of series, et cetera. In the present paper, we study and develop the generalized fractional integral operators given by Saigo. First, we establish two Theorems that give the images of the product of H-function and a general class of polynomials inSaigo operators. On account of the general nature of the Saigo operators, H-function and a general class of polynomials a large number of new and known Images involving Riemann-Liouville and Erdélyi-Kober fractional integral operators and several special functions notably generalized Wright hypergeometric function, generalized Wright-Bessel function, the polylogarithm and Mittag-Leffler functions follow as special cases of our main findings.

  16. Integrating Software Repository Mining: A Decision Support Centered Approach

    Directory of Open Access Journals (Sweden)

    Luiz Dourado Dias Junior

    2012-12-01

    Full Text Available Mining software repositories (MSR research had significantly contributed to software engineering.However, MSR results integration across repositories is a recent concern that is getting more attentionfrom researchers each day. Some noticeable research in this sense is related to the approximation betweenMSR and semantic web, specially linked data approaches which makes it possible to integrate repositoriesand mined results. Manifested that way, we believe that current research is not fully addressing thepractical integration of MSR results, specially, in software engineering due to not considering that theseresults needs to be integrated to the tools as assistance to activity performers, as a kind of decision makingsupport. Based on this statement this research describes an approach, named Sambasore, which isconcerned with MSR results inter-repository integration and also to decision making support processes,based on tool assistance modelling. To show its feasibility we describe the main concepts, some relatedworks and also a proof of concept experiment applied to a software process modelling tool named SpiderPM.

  17. SPATIAL DATA INTEGRATION USING ONTOLOGY-BASED APPROACH

    Directory of Open Access Journals (Sweden)

    S. Hasani

    2015-12-01

    Full Text Available In today's world, the necessity for spatial data for various organizations is becoming so crucial that many of these organizations have begun to produce spatial data for that purpose. In some circumstances, the need to obtain real time integrated data requires sustainable mechanism to process real-time integration. Case in point, the disater management situations that requires obtaining real time data from various sources of information. One of the problematic challenges in the mentioned situation is the high degree of heterogeneity between different organizations data. To solve this issue, we introduce an ontology-based method to provide sharing and integration capabilities for the existing databases. In addition to resolving semantic heterogeneity, better access to information is also provided by our proposed method. Our approach is consisted of three steps, the first step is identification of the object in a relational database, then the semantic relationships between them are modelled and subsequently, the ontology of each database is created. In a second step, the relative ontology will be inserted into the database and the relationship of each class of ontology will be inserted into the new created column in database tables. Last step is consisted of a platform based on service-oriented architecture, which allows integration of data. This is done by using the concept of ontology mapping. The proposed approach, in addition to being fast and low cost, makes the process of data integration easy and the data remains unchanged and thus takes advantage of the legacy application provided.

  18. An integrated approach towards future ballistic neck protection materials selection.

    Science.gov (United States)

    Breeze, John; Helliker, Mark; Carr, Debra J

    2013-05-01

    Ballistic protection for the neck has historically taken the form of collars attached to the ballistic vest (removable or fixed), but other approaches, including the development of prototypes incorporating ballistic material into the collar of an under body armour shirt, are now being investigated. Current neck collars incorporate the same ballistic protective fabrics as the soft armour of the remaining vest, reflecting how ballistic protective performance alone has historically been perceived as the most important property for neck protection. However, the neck has fundamental differences from the thorax in terms of anatomical vulnerability, flexibility and equipment integration, necessitating a separate solution from the thorax in terms of optimal materials selection. An integrated approach towards the selection of the most appropriate combination of materials to be used for each of the two potential designs of future neck protection has been developed. This approach requires evaluation of the properties of each potential material in addition to ballistic performance alone, including flexibility, mass, wear resistance and thermal burden. The aim of this article is to provide readers with an overview of this integrated approach towards ballistic materials selection and an update of its current progress in the development of future ballistic neck protection.

  19. A Simple Transfer Function for Nonlinear Dendritic Integration

    Directory of Open Access Journals (Sweden)

    Matt eSingh

    2015-08-01

    Full Text Available Relatively recent advances in patch clamp recordings and iontophoresis have enabled unprecedented study of neuronal post-synaptic integration (dendritic integration. Findings support a separate layer of integration in the dendritic branches before potentials reach the cell’s soma. While integration between branches obeys previous linear assumptions, proximal inputs within a branch produce threshold nonlinearity, which some authors have likened to the sigmoid function. Here we show the implausibility of a sigmoidal relation and present a more realistic transfer function in both an elegant artificial form and a biophysically derived form that further considers input locations along the dendritic arbor. As the distance between input locations determines their ability to produce nonlinear interactions, models incorporating dendritic topology are essential to understanding the computational power afforded by these early stages of integration. We use the biophysical transfer function to emulate empirical data using biophysical parameters and describe the conditions under which the artificial and biophysically derived forms are equivalent.

  20. Integrals of operator-valued functions

    Directory of Open Access Journals (Sweden)

    Raimond A. Struble

    1988-01-01

    Full Text Available Mikusinski-type expansions of operator-valued functions are discussed in some detail. As a natural part of the development, a “kernel” concept for operators is proposed and an elaborate system of convolution quotients in one and two variables is obtained.

  1. Integration and regulation of cardiovascular function.

    Science.gov (United States)

    Hall, J E

    1999-12-01

    New methods in molecular biology and genetics have made possible many of the dramatic advances in physiological research that have occurred in recent years. For those of us who spend most of our time in the research laboratory, it si sometimes difficult to avoid a research-oriented, reductionist mind-set when discussing physiology with students. This article illustrates, with a few examples, the importance of conveying a "big picture" conceptual framework before discussing the details of cardiovascular physiology. Also, I have chosen examples from cardiac output and blood pressure regulation that show the importance of discussing cardiovascular physiology in terms of feedback control systems and integrating information from other areas, such as renal and endocrine physiology. Finally, I have highlighted the importance of two principles that I believe are often underemphasized in teaching physiology: mass balance and time dependence of physiological control systems.

  2. A novel Bayesian approach to spectral function reconstruction

    CERN Document Server

    Burnier, Yannis

    2013-01-01

    We present a novel approach to the inference of spectral functions from Euclidean time correlator data that makes close contact with modern Bayesian concepts. Our method differs significantly from the maximum entropy method (MEM). A new set of axioms is postulated for the prior probability, leading to an improved expression, which is devoid of the asymptotically flat directions present in the Shanon-Jaynes entropy. Hyperparameters are integrated out explicitly, liberating us from the Gaussian approximations underlying the evidence approach of the MEM. We present a realistic test of our method in the context of the non-perturbative extraction of the heavy quark potential. Based on hard-thermal-loop correlator mock data, we establish firm requirements in the number of data points and their accuracy for a successful extraction of the potential from lattice QCD. An improved potential estimation from previously investigated quenched lattice QCD correlators is provided.

  3. Quantum anharmonic oscillator: The airy function approach

    Energy Technology Data Exchange (ETDEWEB)

    Maiz, F., E-mail: fethimaiz@gmail.com [King Khalid University, Faculty of Science, Physics Department, PO Box 9004, Abha 61413, Asseer (Saudi Arabia); University of Cartage, Nabeul Engineering Preparatory Institute, Merazka, 8000 Nabeul (Tunisia); AlFaify, S. [King Khalid University, Faculty of Science, Physics Department, PO Box 9004, Abha 61413, Asseer (Saudi Arabia)

    2014-05-15

    New and simple numerical method is being reported to solve anharmonic oscillator problems. The method is setup to approach the real potential V(x) of the anharmonic oscillator system as a piecewise linear potential u(x) and to solve the Schrödinger equation of the system using the Airy function. Then, solutions continuity conditions lead to the energy quantification condition, and consequently, the energy eigenvalues. For testing purpose, the method was applied on the sextic and octic oscillators systems. The proposed method is found to be realistic, computationally simple, and having high degrees of accuracy. In addition, it can be applied to any form of potential. The results obtained by the proposed method were seen closely agreeing with results reached by other complicated methods.

  4. Environmental planning, ecosystem science, and ecosystem approaches for integrating environment and development

    Science.gov (United States)

    Slocombe, D. Scott

    1993-05-01

    Currently popular concepts such as sustainable development and sustainability seek the integration of environment and development planning. However, there is little evidence that this integration is occurring in either mainstream development planning or environmental planning. This is a function of the history, philosophies, and evolved roles of both. A brief review of the experience and results of mainstream planning, environmental planning, and ecosystem science suggests there is much in past scientific and professional practice that is relevant to the goal of integrated planning for environment and development, but still such commonly recommended reforms as systems and multidisciplinary approaches, institutional integration, and participatory, goal-oriented processes are rarely achieved. “Ecosystem approaches,” as developed and applied in ecology, human ecology, environmental planning, anthropology, psychology, and other disciplines, may provide a more transdisciplinary route to successful integration of environment and development. Experience with ecosystem approaches is reviewed, their advantages and disadvantages are discussed, and they are compared to traditional urban and regional planning, environmental planning, and ecosystem science approaches. Ultimately a synthesis of desirable characteristics for a framework to integrate environment and development planning is presented as a guide for future work and a criterion for evaluating existing programs.

  5. Self-Potential data inversion through the integration of spectral analysis and tomographic approaches

    Science.gov (United States)

    Di Maio, Rosa; Piegari, Ester; Rani, Payal; Avella, Adolfo

    2016-08-01

    An integrated approach to interpret Self-Potential (SP) anomalies based on spectral analysis and tomographic methods is presented. The Maximum Entropy Method (MEM) is used for providing accurate estimates of the depth of the anomaly source. The 2-D tomographic inversion technique, based on the underground charge occurrence probability (COP) function, is, then, used to fully characterize the anomalous body, as the MEM is not helpful in delineating the shape of the anomaly source. The proposed integrated approach is applied for the inversion of synthetic SP data generated by geometrically simple anomalous bodies, such as cylinders and inclined sheets. This numerical study has allowed the determination of mathematical relationships between zero lines of the COP distributions, the polarization angles and the positions along the profile of the causative sources, which have been of great help for interpreting the related SP anomalies. Finally, the analysis of field examples shows the high potential applicability of the proposed integrated approach for SP data inversion.

  6. Further results on stabilization for interval time-delay systems via new integral inequality approach.

    Science.gov (United States)

    Li, Zhichen; Bai, Yan; Huang, Congzhi; Yan, Huaicheng

    2017-05-01

    This paper investigates the stability and stabilization problems for interval time-delay systems. By introducing a new delay partitioning approach, various Lyapunov-Krasovskii functionals with triple-integral terms are established to make full use of system information. In order to reduce the conservatism, improved integral inequalities are developed for estimation of double integrals, which show remarkable outperformance over the Jensen and Wirtinger ones. Particularly, the relationship between the time-delay and each subinterval is taken into consideration. The resulting stability criteria are less conservative than some recent methods. Based on the derived condition, the state-feedback controller design approach is also given. Finally, the numerical examples and the application to inverted pendulum system are provided to illustrate the effectiveness of the proposed approaches. Copyright © 2017 ISA. Published by Elsevier Ltd. All rights reserved.

  7. Pay-as-you-go data integration using functional dependencies

    NARCIS (Netherlands)

    Ayat, N.; Afsarmanesh, H.; Akbarinia, R.; Valduriez, P.

    2012-01-01

    Setting up a full data integration system for many application contexts, e.g. web and scientific data management, requires significant human effort which prevents it from being really scalable. In this paper, we propose IFD (Integration based on Functional Dependencies), a pay-as-you-go data integra

  8. Audiovisual Integration in High Functioning Adults with Autism

    Science.gov (United States)

    Keane, Brian P.; Rosenthal, Orna; Chun, Nicole H.; Shams, Ladan

    2010-01-01

    Autism involves various perceptual benefits and deficits, but it is unclear if the disorder also involves anomalous audiovisual integration. To address this issue, we compared the performance of high-functioning adults with autism and matched controls on experiments investigating the audiovisual integration of speech, spatiotemporal relations, and…

  9. DUAL INTEGRAL EQUATIONS INVOLVING LEGENDRE FUNCTIONS IN DISTRIBUTION SPACES

    Directory of Open Access Journals (Sweden)

    P. K. BANERJI, DESHNA LOONKER

    2010-11-01

    Full Text Available In this paper we use the Mehler-Fock transformation to obtain thesolution of dual integral equations involving Legendre functions. The solutionso obtained is proved to be distributional because they satisfy properties ofdistribution space.

  10. Does a Functional Integral Really Need a Lagrangian?

    Directory of Open Access Journals (Sweden)

    D. Kochan

    2010-01-01

    Full Text Available Path integral formulation of quantum mechanics (and also other equivalent formulations depends on a Lagrangian and/or Hamiltonian function that is chosen to describe the underlying classical system. The arbitrariness presented in this choice leads to a phenomenon called Quantization ambiguity. For example both L1 = ˙q2 and L2 = eq˙ are suitable Lagrangians on a classical level (δL1 = δL2, but quantum mechanically they are diverse. This paper presents a simple rearrangement of the path integral to a surface functional integral. It is shown that the surface functional integral formulation gives transition probability amplitude which is free of any Lagrangian/Hamiltonian and requires just the underlying classical equations of motion. A simple example examining the functionality of the proposed method is considered.

  11. Teaching Service Modelling to a Mixed Class: An Integrated Approach

    Directory of Open Access Journals (Sweden)

    Jeremiah D. DENG

    2015-04-01

    Full Text Available Service modelling has become an increasingly important area in today's telecommunications and information systems practice. We have adapted a Network Design course in order to teach service modelling to a mixed class of both the telecommunication engineering and information systems backgrounds. An integrated approach engaging mathematics teaching with strategies such as problem-solving, visualization, and the use of examples and simulations, has been developed. From assessment on student learning outcomes, it is indicated that the proposed course delivery approach succeeded in bringing out comparable and satisfactory performance from students of different educational backgrounds.

  12. Integrated Control Strategies Supporting Autonomous Functionalities in Mobile Robots

    Science.gov (United States)

    2005-01-01

    Integrated Control Strategies Supporting Autonomous Functionalities in Mobile Robots B. Sightsa, H.R. Everetta, E. Biagtan Pacisa, G. Koguta M...TYPE N/A 3. DATES COVERED - 4. TITLE AND SUBTITLE Integrated Control Strategies Supporting Autonomous Functionalities in Mobile Robots 5a...calculation methods using encoder counts, wheel radius, and the robot’s wheelbase, as described in Sensors For Mobile Robots [5]. On top of this

  13. An integral estimate of Bessel function and its application

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    In this paper the authors give a new integral estimate of the Bessel function,which is an extension of Calder(?)n-Zygmund’s result.As an application of this result,we prove that the parameterized Marcinkiewicz integralμ_Ω~p with variable kernels is of type (2,2),where the kernel functionΩdoes not have any smoothness on the unit sphere in R~n.

  14. Integral Representation of Harmonic Function in a Half-Plane

    Institute of Scientific and Technical Information of China (English)

    LI Hong Wei; DENG Guan Tie

    2009-01-01

    In this article, we consider the integral representation of harmonic functions. Using a property of the modified Poisson kernel in a half plane, we prove that a harmonic function u(z) in a half plane with its positive part u+(z)=max{u(z), 0} satisfying a slowly growing condition can be represented by its integral of a measure on the boundary of the half plan.

  15. Toward Intelligent Hemodynamic Monitoring: A Functional Approach

    Directory of Open Access Journals (Sweden)

    Pierre Squara

    2012-01-01

    Full Text Available Technology is now available to allow a complete haemodynamic analysis; however this is only used in a small proportion of patients and seems to occur when the medical staff have the time and inclination. As a result of this, significant delays occur between an event, its diagnosis and therefore, any treatment required. We can speculate that we should be able to collect enough real time information to make a complete, real time, haemodynamic diagnosis in all critically ill patients. This article advocates for “intelligent haemodynamic monitoring”. Following the steps of a functional analysis, we answered six basic questions. (1 What is the actual best theoretical model for describing haemodynamic disorders? (2 What are the needed and necessary input/output data for describing this model? (3 What are the specific quality criteria and tolerances for collecting each input variable? (4 Based on these criteria, what are the validated available technologies for monitoring each input variable, continuously, real time, and if possible non-invasively? (5 How can we integrate all the needed reliably monitored input variables into the same system for continuously describing the global haemodynamic model? (6 Is it possible to implement this global model into intelligent programs that are able to differentiate clinically relevant changes as opposed to artificial changes and to display intelligent messages and/or diagnoses?

  16. On Parameter Differentiation for Integral Representations of Associated Legendre Functions

    Science.gov (United States)

    Cohl, Howard S.

    2011-05-01

    For integral representations of associated Legendre functions in terms of modified Bessel functions, we establish justification for differentiation under the integral sign with respect to parameters. With this justification, derivatives for associated Legendre functions of the first and second kind with respect to the degree are evaluated at odd-half-integer degrees, for general complex-orders, and derivatives with respect to the order are evaluated at integer-orders, for general complex-degrees. We also discuss the properties of the complex function f: C\\{-1,1}→C given by f(z)=z/((z+1)1/2(z-1)1/2).

  17. On parameter differentiation for integral representations of associated Legendre functions

    CERN Document Server

    Cohl, Howard S

    2011-01-01

    For integral representations of associated Legendre functions in terms of modified Bessel functions, we establish justification for differentiation under the integral sign with respect to parameters. With this justification, derivatives for associated Legendre functions of the first and second kind with respect to the degree are evaluated at odd-half-integer degrees, for general complex-orders, and derivatives with respect to the order are evaluated at integer-orders, for general complex-degrees. We also discuss the properties of the complex function $f:\\C\\setminus\\{-1,1\\}\\to\\C$ given by $f(z)=z/\\sqrt{(z+1)(z-1)}$.

  18. Modelling of multidimensional quantum systems by the numerical functional integration

    Energy Technology Data Exchange (ETDEWEB)

    Lobanov, Yu.Yu.; Zhidkov, E.P. (Joint Inst. for Nuclear Research, Dubna (USSR)); Shahbagian, R.R. (Yerevan Physics Inst., Erevan (USSR))

    1990-01-01

    The employment of the numerical functional integration for the description of multidimensional systems in quantum and statistical physics is considered. For the multiple functional integrals with respect to Gaussian measures in the full separable metric spaces the new approximation formulas exact on a class of polynomial functionals of a given summary degree are constructed. The use of the formulas is demonstrated on example of computation of the Green function and the ground state energy in multidimensional Calogero model. The comparison of numerical results with the data obtained by the other authors which used the Monte Carlo method combined with iterative algorithms indicates that our formulas provide the higher efficiency of computations.

  19. First- and third-person approaches: the problem of integration

    OpenAIRE

    2012-01-01

    The author discusses the problem of integration of first- and third-person approaches in studying the human mind. She critically evaluates and compares various methodologies for studying and explaining conscious experience. Common strategies that apply reductive explanation seem to be unsatisfied for explaining experience and its subjective character. There were attempts to explain experience from the first-person point of view (introspectionism, philosophical phenomenology) but the results w...

  20. An Integrated approach to the Space Situational Awareness Problem

    Science.gov (United States)

    2016-12-15

    AFRL-AFOSR-VA-TR-2016-0377 An Integrated approach to the Space Situational Awareness Problem Suman Chakravorty TEXAS ENGINEERING EXPERIMENT STATION...including suggestions for reducing the burden, to the Department of Defense, Executive Service Directorate (0704-0188). Respondents should be aware that...Situational Awareness Problem 5a. CONTRACT NUMBER 5b. GRANT NUMBER FA9550-13-1-0074 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) Dr. Suman Chakravorty 5d

  1. An innovation integrated approach to testing motorcycle drive chain lubricants

    OpenAIRE

    Lee, P.M.; Priest, M.

    2004-01-01

    An innovative integrated approach to the testing and comparison of motorcycle drive chain lubricants is presented. This is a novel way of testing the lubrication by using loaded operating chains and sprockets. A test rig has been designed to operate chains and sprockets in a clean environment and allow direct comparison between different lubricants. The advantage of this method over previous techniques is that it allows the differentiation of lubricants in a more controlled operating environm...

  2. An integrated micro-macro approach to robust railway timetabling

    DEFF Research Database (Denmark)

    Bešinović, Nikola; Goverde, Rob M P; Quaglietta, Egidio

    2016-01-01

    With the increasing demand for railway transportation infrastructure managers need improved automatic timetabling tools that provide feasible timetables with enhanced performance in short computation times. This paper proposes a hierarchical framework for timetable design which combines...... robustness using an Integer Linear Programming formulation which includes a measure for delay recovery computed by an integrated delay propagation model in a Monte Carlo setting. The application to an area of the Dutch railway network shows the ability of the approach to automatically compute a feasible...

  3. An integrated MCDM approach to green supplier selection

    OpenAIRE

    Morteza Yazdani

    2014-01-01

    Supplier selection management has been considered as an important subject for industrial organizations. In order to remain on the market, to gain profitability and to retain competitive advantage, business units need to establish an integrated and structured supplier selection system. In addition, environmental protection problems have been big solicitudes for organizations to consider green approach in supplier selection problem. However, finding proper suppliers involves several variables a...

  4. An Integrated Approach to the Assessment of Energy Conversion Plants

    OpenAIRE

    Simone Tonon; Anna Stoppato; Alberto Mirandola

    2010-01-01

    An integrated approach to the assessment of energy systems behaviour with regard to energetic, economic and environmental viewpoints is suggested. For each aspect, suitable performance indicators are defined, evaluated and then normalised in order that the same numerical value is calculated for qualitatively equivalent performances even if related to different aspects; application of these indicators can address policy makers, designers and plant operators towards a fair compromise a...

  5. Workplace mental health: developing an integrated intervention approach.

    Science.gov (United States)

    LaMontagne, Anthony D; Martin, Angela; Page, Kathryn M; Reavley, Nicola J; Noblet, Andrew J; Milner, Allison J; Keegel, Tessa; Smith, Peter M

    2014-05-09

    Mental health problems are prevalent and costly in working populations. Workplace interventions to address common mental health problems have evolved relatively independently along three main threads or disciplinary traditions: medicine, public health, and psychology. In this Debate piece, we argue that these three threads need to be integrated to optimise the prevention of mental health problems in working populations. To realise the greatest population mental health benefits, workplace mental health intervention needs to comprehensively 1) protect mental health by reducing work-related risk factors for mental health problems; 2) promote mental health by developing the positive aspects of work as well as worker strengths and positive capacities; and 3) address mental health problems among working people regardless of cause. We outline the evidence supporting such an integrated intervention approach and consider the research agenda and policy developments needed to move towards this goal, and propose the notion of integrated workplace mental health literacy. An integrated approach to workplace mental health combines the strengths of medicine, public health, and psychology, and has the potential to optimise both the prevention and management of mental health problems in the workplace.

  6. Communicative functions integrate segments in prosodies and prosodies in segments.

    Science.gov (United States)

    Kohler, Klaus J

    2011-01-01

    This paper takes a new look at the traditionally established divide between sounds and prosodies, viewing it as a useful heuristics in language descriptions that focus on the segmental make- up of words. It pleads for a new approach that bridges this reified compartmentalization of speech in a more global communicative perspective. Data are presented from a German perception experiment in the framework of the Semantic Differential that shows interdependence of f0 contours and the spectral characteristics of a following fricative segment, for the expression of semantic functions along the scales questioning - asserting, excited - calm, forceful - not forceful, contrary - agreeable. The results lead to the conclusion that segments shape prosodies and are shaped by them in varying ways in the coding of semantic functions. This implies that the analysis of sentence prosodies needs to integrate the manifestation of segments, just as the analysis of segments needs to consider their prosodic embedding. In communicative interaction, speakers set broad prosodic time windows of varying sizes, and listeners respond to them. So, future phonetic research needs to concentrate on speech analysis in such windows.

  7. [Integrative approach in the psychotherapy of borderline personality disorder].

    Science.gov (United States)

    Kuritárné Szabó, Ildikó

    2012-01-01

    In the last 20 years six psychotherapy methods have been developed specifically for borderline personality disorder. Solid RCT evidences suggests the efficacy of all the methods. Roughly equivalent improvement was obtained from the different types of psychotherapies. Today we have reached a new phase of the borderline "psychotherapy boom", the integrative approach. According to the integrative treatment advocates we should not choose among these effective treatments but we can incorporate in the therapy all the components that work. The integrative approach uses general factors common to all effective therapies, combined with specific treatment techniques taken from different therapies in order to treat the given patient's psychopathology. These common factors are: coherent framework; attention to strategies for building strong positive alliance and maintaining patient motivation; creating a safe and structured therapeutic environment; clear treatment frame; transparency of the goals and roles; focus upon presenting problems; higher level therapeutic activity; here-and-now focus; and facilitating self-reflection. Treatment focuses on change while maintaining a validating and supportive stance. General strategies can be supplemented by more specific techniques such as cognitive-behavioral interventions for reducing maladaptive behavior, training for developing emotion regulation skills and interpersonal skills coming from dialectical behavior therapy. Methods drawn from psychodynamic approaches can be used for the modification of underlying interpersonal cognitive-emotional schemas.

  8. An Integrated Approach for Urban Earthquake Vulnerability Analyses

    Science.gov (United States)

    Düzgün, H. S.; Yücemen, M. S.; Kalaycioglu, H. S.

    2009-04-01

    The earthquake risk for an urban area has increased over the years due to the increasing complexities in urban environments. The main reasons are the location of major cities in hazard prone areas, growth in urbanization and population and rising wealth measures. In recent years physical examples of these factors are observed through the growing costs of major disasters in urban areas which have stimulated a demand for in-depth evaluation of possible strategies to manage the large scale damaging effects of earthquakes. Understanding and formulation of urban earthquake risk requires consideration of a wide range of risk aspects, which can be handled by developing an integrated approach. In such an integrated approach, an interdisciplinary view should be incorporated into the risk assessment. Risk assessment for an urban area requires prediction of vulnerabilities related to elements at risk in the urban area and integration of individual vulnerability assessments. However, due to complex nature of an urban environment, estimating vulnerabilities and integrating them necessities development of integrated approaches in which vulnerabilities of social, economical, structural (building stock and infrastructure), cultural and historical heritage are estimated for a given urban area over a given time period. In this study an integrated urban earthquake vulnerability assessment framework, which considers vulnerability of urban environment in a holistic manner and performs the vulnerability assessment for the smallest administrative unit, namely at neighborhood scale, is proposed. The main motivation behind this approach is the inability to implement existing vulnerability assessment methodologies for countries like Turkey, where the required data are usually missing or inadequate and decision makers seek for prioritization of their limited resources in risk reduction in the administrative districts from which they are responsible. The methodology integrates socio

  9. Evaluation of a Family of Bessel Function Integrals

    CERN Document Server

    Birrell, Jeremiah

    2015-01-01

    We investigate a family of integrals involving modified Bessel functions that arise in the context of neutrino scattering. Recursive formulas are derived for evaluating these integrals and their asymptotic expansions are computed. We prove in certain cases that the asymptotic expansion yields the exact result after a finite number of terms. In each of these cases we derive a formula that bounds the order at which the expansion terminates. The method of calculation developed in this paper is applicable to similar families of integrals that involve Bessel or modified Bessel functions.

  10. Finding new relationships between hypergeometric functions by evaluating Feynman integrals

    Energy Technology Data Exchange (ETDEWEB)

    Kniehl, Bernd A. [Santa Barbara Univ., CA (United States). Kavli Inst. for Theoretical Physics; Tarasov, Oleg V. [Hamburg Univ. (Germany). 2. Inst. fuer Theoretische Physik

    2011-08-15

    Several new relationships between hypergeometric functions are found by comparing results for Feynman integrals calculated using different methods. A new expression for the one-loop propagator-type integral with arbitrary masses and arbitrary powers of propagators is derived in terms of only one Appell hypergeometric function F{sub 1}. From the comparison of this expression with a previously known one, a new relation between the Appell functions F{sub 1} and F{sub 4} is found. By comparing this new expression for the case of equal masses with another known result, a new formula for reducing the F{sub 1} function with particular arguments to the hypergeometric function {sub 3}F{sub 2} is derived. By comparing results for a particular one-loop vertex integral obtained using different methods, a new relationship between F{sub 1} functions corresponding to a quadratic transformation of the arguments is established. Another reduction formula for the F{sub 1} function is found by analysing the imaginary part of the two-loop self-energy integral on the cut. An explicit formula relating the F{sub 1} function and the Gaussian hypergeometric function {sub 2}F{sub 1} whose argument is the ratio of polynomials of degree six is presented. (orig.)

  11. Improved stability and stabilization design for networked control systems using new quadruple-integral functionals.

    Science.gov (United States)

    Li, Zhichen; Bai, Yan; Li, Tianqi

    2016-07-01

    This paper investigates stability analysis and stabilization for networked control systems. By a refined delay decomposition approach, slightly different Lyapunov-Krasovskii functionals (LKFs) with quadruple-integral terms and augmented vectors containing triple-integral forms of state are constructed. New integral inequalities are proposed to estimate the cross terms from derivatives of the LKFs, which can be proved to offer tighter bounds than what the Jensen one produces theoretically. Moreover, the non-strictly proper rational functions in deriving process are fully handled via reciprocally convex approach. A state feedback controller design approach is also developed. Numerical examples and applications to practical power and oscillator systems demonstrate the superiority of the proposed criteria in conservatism reduction compared to some existing ones.

  12. Fuzzy set approach to quality function deployment: An investigation

    Science.gov (United States)

    Masud, Abu S. M.

    1992-01-01

    The final report of the 1992 NASA/ASEE Summer Faculty Fellowship at the Space Exploration Initiative Office (SEIO) in Langley Research Center is presented. Quality Function Deployment (QFD) is a process, focused on facilitating the integration of the customer's voice in the design and development of a product or service. Various input, in the form of judgements and evaluations, are required during the QFD analyses. All the input variables in these analyses are treated as numeric variables. The purpose of the research was to investigate how QFD analyses can be performed when some or all of the input variables are treated as linguistic variables with values expressed as fuzzy numbers. The reason for this consideration is that human judgement, perception, and cognition are often ambiguous and are better represented as fuzzy numbers. Two approaches for using fuzzy sets in QFD have been proposed. In both cases, all the input variables are considered as linguistic variables with values indicated as linguistic expressions. These expressions are then converted to fuzzy numbers. The difference between the two approaches is due to how the QFD computations are performed with these fuzzy numbers. In Approach 1, the fuzzy numbers are first converted to their equivalent crisp scores and then the QFD computations are performed using these crisp scores. As a result, the output of this approach are crisp numbers, similar to those in traditional QFD. In Approach 2, all the QFD computations are performed with the fuzzy numbers and the output are fuzzy numbers also. Both the approaches have been explained with the help of illustrative examples of QFD application. Approach 2 has also been applied in a QFD application exercise in SEIO, involving a 'mini moon rover' design. The mini moon rover is a proposed tele-operated vehicle that will traverse and perform various tasks, including autonomous operations, on the moon surface. The output of the moon rover application exercise is a

  13. Soil eukaryotic functional diversity, a metatranscriptomic approach.

    Science.gov (United States)

    Bailly, Julie; Fraissinet-Tachet, Laurence; Verner, Marie-Christine; Debaud, Jean-Claude; Lemaire, Marc; Wésolowski-Louvel, Micheline; Marmeisse, Roland

    2007-11-01

    To appreciate the functional diversity of communities of soil eukaryotic micro-organisms we evaluated an experimental approach based on the construction and screening of a cDNA library using polyadenylated mRNA extracted from a forest soil. Such a library contains genes that are expressed by each of the different organisms forming the community and represents its metatranscriptome. The diversity of the organisms that contributed to this library was evaluated by sequencing a portion of the 18S rDNA gene amplified from either soil DNA or reverse-transcribed RNA. More than 70% of the sequences were from fungi and unicellular eukaryotes (protists) while the other most represented group was the metazoa. Calculation of richness estimators suggested that more than 180 species could be present in the soil samples studied. Sequencing of 119 cDNA identified genes with no homologues in databases (32%) and genes coding proteins involved in different biochemical and cellular processes. Surprisingly, the taxonomic distribution of the cDNA and of the 18S rDNA genes did not coincide, with a marked under-representation of the protists among the cDNA. Specific genes from such an environmental cDNA library could be isolated by expression in a heterologous microbial host, Saccharomyces cerevisiae. This is illustrated by the functional complementation of a histidine auxotrophic yeast mutant by two cDNA originating possibly from an ascomycete and a basidiomycete fungal species. Study of the metatranscriptome has the potential to uncover adaptations of whole microbial communities to local environmental conditions. It also gives access to an abundant source of genes of biotechnological interest.

  14. Porocytosis: a new approach to synaptic function.

    Science.gov (United States)

    Kriebel, M E; Keller, B; Silver, R B; Fox, G Q; Pappas, G D

    2001-12-01

    We propose a new approach to address the question of how a single quantum of neurotransmitter is secreted from a presynaptic terminal whose clustered secretory vesicles are locally bathed in high levels of calcium ions [Proceedings of the Symposium on Bioelectrogenesis (1961) 297-309; The Physiology of Synapses (1964) Chapters 1, 4, 5, 6; How the Self Controls its Brain (1994) Chapters 1, 4, 5, 6; Science 256 (1992) 677-679]. This hypothesis, which we term 'porocytosis', posits that the post-synaptic quantal response results from transmitter secreted through an array of docked vesicle/secretory pore complexes. The transient increase in calcium ions, which results from the voltage activated calcium channels, stimulates the array of secretory pores to simultaneously flicker open to pulse transmitter. Porocytosis is consistent with the quantal nature of presynaptic secretion and transmission, and with available biochemical, morphological and physiological evidence. It explains the frequency dependency of quantal size as a function of the secretion process. It permits a signature amount of transmitter release for different frequencies allowing a given synapse to be employed in different behavioral responses. The porocytosis hypothesis permits fidelity of secretion and the seemingly apposed characteristic of synaptic plasticity. The dynamics inherent in an array insure a constant quantal size as a function of the number of units within the array. In this hypothesis, plasticity is a consequence of concurrent pre- and post-synaptic changes due to a change in array size. Changes in the number of docked vesicle-secretory pore complexes composing the array can explain facilitation, depletion, graded excitation-secretion and long term plasticity.

  15. Numerical integration of discontinuous functions: moment fitting and smart octree

    Science.gov (United States)

    Hubrich, Simeon; Di Stolfo, Paolo; Kudela, László; Kollmannsberger, Stefan; Rank, Ernst; Schröder, Andreas; Düster, Alexander

    2017-07-01

    A fast and simple grid generation can be achieved by non-standard discretization methods where the mesh does not conform to the boundary or the internal interfaces of the problem. However, this simplification leads to discontinuous integrands for intersected elements and, therefore, standard quadrature rules do not perform well anymore. Consequently, special methods are required for the numerical integration. To this end, we present two approaches to obtain quadrature rules for arbitrary domains. The first approach is based on an extension of the moment fitting method combined with an optimization strategy for the position and weights of the quadrature points. In the second approach, we apply the smart octree, which generates curved sub-cells for the integration mesh. To demonstrate the performance of the proposed methods, we consider several numerical examples, showing that the methods lead to efficient quadrature rules, resulting in less integration points and in high accuracy.

  16. Market appeal intelligently evaluation basing on integral monitoring functions using

    Directory of Open Access Journals (Sweden)

    A.P. Kosenko

    2014-06-01

    which most closely corresponds to the solution of the problem. For original technologies that do not have a basis for comparison, integral quality index is determined using the theory of quality control. The efficiency of the use of mechanism of sharing monitoring functions will increase significantly. Suggested to be used using the Cartesian coordinate system. Valuations in this coordinate system are proposed to carry out using the values of monitoring functions. Thus, the calculated values of the area of joint action monitoring functions allow analyzing, evaluating and managing the state of the commercial potential of smart technologies, prepared by their developer to commercialization. Sharing monitoring functions allows continuous monitoring of commercial situations that arise on the technology market in a timely manner to prevent undesirable trends in the field of intellectual activity in the enterprise, and the target technology market its products. Conclusions and directions of further researches. The proposed approach to the study of the level of the commercial potential of technology products has scientific value, characterized by originality and novelty. It allows formalizing the process of analyzing and predicting the transfer capabilities of the enterprise developer, and can be further applied in practice developers of technology products (intellectual property in the justification of the marketing program for the target technology market.

  17. Rigorous time slicing approach to Feynman path integrals

    CERN Document Server

    Fujiwara, Daisuke

    2017-01-01

    This book proves that Feynman's original definition of the path integral actually converges to the fundamental solution of the Schrödinger equation at least in the short term if the potential is differentiable sufficiently many times and its derivatives of order equal to or higher than two are bounded. The semi-classical asymptotic formula up to the second term of the fundamental solution is also proved by a method different from that of Birkhoff. A bound of the remainder term is also proved. The Feynman path integral is a method of quantization using the Lagrangian function, whereas Schrödinger's quantization uses the Hamiltonian function. These two methods are believed to be equivalent. But equivalence is not fully proved mathematically, because, compared with Schrödinger's method, there is still much to be done concerning rigorous mathematical treatment of Feynman's method. Feynman himself defined a path integral as the limit of a sequence of integrals over finite-dimensional spaces which is obtained by...

  18. Integrated Treatment to Achieve Functional Recovery for First-Episode Psychosis

    Directory of Open Access Journals (Sweden)

    Marcelo Valencia

    2012-01-01

    Full Text Available This study describes an integrated treatment approach that was implemented to enhance functional recovery in first-episode psychotic patients. Patients were randomized to two treatment conditions: either to an integrated treatment approach: pharmacotherapy, psychosocial treatment, and psychoeducation (experimental group: N=39 or to medication alone (control group: N=34. Patients were evaluated at baseline and after one year of treatment. Functional recovery was assessed according to symptomatic and functional remission. At the end of treatment, experimental patients showed a 94.9% of symptomatic remission compared to 58.8% of the control group. Functional remission was 56.4% for the experimental group and 3.6% for the control group, while 56.4% of the experimental group met both symptomatic and functional remission criteria and were considered recovered compared to 2.9% of the control group.

  19. Thermoplasmonics modeling: A Green's function approach

    Science.gov (United States)

    Baffou, Guillaume; Quidant, Romain; Girard, Christian

    2010-10-01

    We extend the discrete dipole approximation (DDA) and the Green’s dyadic tensor (GDT) methods—previously dedicated to all-optical simulations—to investigate the thermodynamics of illuminated plasmonic nanostructures. This extension is based on the use of the thermal Green’s function and a original algorithm that we named Laplace matrix inversion. It allows for the computation of the steady-state temperature distribution throughout plasmonic systems. This hybrid photothermal numerical method is suited to investigate arbitrarily complex structures. It can take into account the presence of a dielectric planar substrate and is simple to implement in any DDA or GDT code. Using this numerical framework, different applications are discussed such as thermal collective effects in nanoparticles assembly, the influence of a substrate on the temperature distribution and the heat generation in a plasmonic nanoantenna. This numerical approach appears particularly suited for new applications in physics, chemistry, and biology such as plasmon-induced nanochemistry and catalysis, nanofluidics, photothermal cancer therapy, or phase-transition control at the nanoscale.

  20. A DSM-based framework for integrated function modelling

    DEFF Research Database (Denmark)

    Eisenbart, Boris; Gericke, Kilian; Blessing, Lucienne T. M.

    2017-01-01

    an integrated function modelling framework, which specifically aims at relating between the different function modelling perspectives prominently addressed in different disciplines. It uses interlinked matrices based on the concept of DSM and MDM in order to facilitate cross-disciplinary modelling and analysis...

  1. Riccati equation-based generalization of Dawson's integral function

    CERN Document Server

    Messina, R; Messina, A; Napoli, A

    2007-01-01

    A new generalization of Dawson's integral function based on the link between a Riccati nonlinear differential equation and a second-order ordinary differential equation is reported. The MacLaurin expansion of this generalized function is built up and to this end an explicit formula for a generic cofactor of a triangular matrix is deduced.

  2. Integrability of the Fourier transform: functions of bounded variation

    CERN Document Server

    Liflyand, E

    2012-01-01

    Certain relations between the Fourier transform of a function of bounded variation and the Hilbert transform of its derivative are revealed. The widest subspaces of the space of functions of bounded variation are indicated in which the cosine and sine Fourier transforms are integrable.

  3. STRONGLY CONTINUOUS INTEGRATED COSINE OPERATOR FUNCTIONS WITH GROWTH ω

    Institute of Scientific and Technical Information of China (English)

    Meiying Wang; Guoxiang Chen

    2007-01-01

    For a continuous increasing function ω: [0, ∞) → (0, ∞) of finite exponetial type, we establish a Hille-Yosida type theorem for strongly continuous integrated cosine operator functions with O(ω). It includes the well-known polynomially bounded and exponentially bounded cases.

  4. On Integral Means of Star-Like Functions

    Indian Academy of Sciences (India)

    Larisa Gromova; Alexander Vasil'ev

    2002-11-01

    We study univalent holomorphic functions in the unit disk $U = \\{z:|z| < 1\\}$ of the form $f(z) = z + _{n=2}^∞ a_n z^n$ that satisfy the condition Re $zf'(z)/f(z) > $ with $ \\in [0, 1)$ in . Some integral means of such functions are estimated.

  5. Spaceability and algebrability of sets of nowhere integrable functions

    CERN Document Server

    Glab, Szymon; Pellegrini, Leonardo

    2012-01-01

    We show that the set of Lebesgue integrable functions in $[0,1]$ which are nowhere essentially bounded is spaceable, improving a result from [F. J. Garc\\'{i}a-Pacheco, M. Mart\\'{i}n, and J. B. Seoane-Sep\\'ulveda. \\textit{Lineability, spaceability, and algebrability of certain subsets of function spaces,} Taiwanese J. Math., \\textbf{13} (2009), no. 4, 1257--1269], and that it is strongly $\\mathfrak{c}$-algebrable. We prove strong $\\mathfrak{c}$-algebrability and non-separable spaceability of the set of functions of bounded variation which have a dense set of jump discontinuities. Applications to sets of Lebesgue-nowhere-Riemann integrable and Riemann-nowhere-Newton integrable functions are presented as corollaries. In addition we prove that the set of Kurzweil integrable functions which are not Lebesgue integrable is spaceable (in the Alexievicz norm) but not 1-algebrable. We also show that there exists an infinite dimensional vector space $S$ of differentiable functions such that each element of the $C([0,1])...

  6. General Green's function formalism for layered systems: Wave function approach

    Science.gov (United States)

    Zhang, Shu-Hui; Yang, Wen; Chang, Kai

    2017-02-01

    The single-particle Green's function (GF) of mesoscopic structures plays a central role in mesoscopic quantum transport. The recursive GF technique is a standard tool to compute this quantity numerically, but it lacks physical transparency and is limited to relatively small systems. Here we present a numerically efficient and physically transparent GF formalism for a general layered structure. In contrast to the recursive GF that directly calculates the GF through the Dyson equations, our approach converts the calculation of the GF to the generation and subsequent propagation of a scattering wave function emanating from a local excitation. This viewpoint not only allows us to reproduce existing results in a concise and physically intuitive manner, but also provides analytical expressions of the GF in terms of a generalized scattering matrix. This identifies the contributions from each individual scattering channel to the GF and hence allows this information to be extracted quantitatively from dual-probe STM experiments. The simplicity and physical transparency of the formalism further allows us to treat the multiple reflection analytically and derive an analytical rule to construct the GF of a general layered system. This could significantly reduce the computational time and enable quantum transport calculations for large samples. We apply this formalism to perform both analytical analysis and numerical simulation for the two-dimensional conductance map of a realistic graphene p -n junction. The results demonstrate the possibility of observing the spatially resolved interference pattern caused by negative refraction and further reveal a few interesting features, such as the distance-independent conductance and its quadratic dependence on the carrier concentration, as opposed to the linear dependence in uniform graphene.

  7. ABOUT COMPLEX APPROACH TO MODELLING OF TECHNOLOGICAL MACHINES FUNCTIONING

    Directory of Open Access Journals (Sweden)

    A. A. Honcharov

    2015-01-01

    Full Text Available Problems arise in the process of designing, production and investigation of a complicated technological machine. These problems concern not only properties of some types of equipment but they have respect to regularities of control object functioning as a whole. A technological machine is thought of as such technological complex where it is possible to lay emphasis on a control system (or controlling device and a controlled object. The paper analyzes a number of existing approaches to construction of models for controlling devices and their functioning. A complex model for a technological machine operation has been proposed in the paper; in other words it means functioning of a controlling device and a controlled object of the technological machine. In this case models of the controlling device and the controlled object of the technological machine can be represented as aggregate combination (elements of these models. The paper describes a conception on realization of a complex model for a technological machine as a model for interaction of units (elements in the controlling device and the controlled object. When a control activation is given to the controlling device of the technological machine its modelling is executed at an algorithmic or logic level and the obtained output signals are interpreted as events and information about them is transferred to executive mechanisms.The proposed scheme of aggregate integration considers element models as object classes and the integration scheme is presented as a combination of object property values (combination of a great many input and output contacts and combination of object interactions (in the form of an integration operator. Spawn of parent object descendants of the technological machine model and creation of their copies in various project parts is one of the most important means of the distributed technological machine modelling that makes it possible to develop complicated models of

  8. Process modeling of comprehensive integrated forest biorefinery--an integrated approach.

    Science.gov (United States)

    Huang, Hua-Jiang; Lin, Weilu; Ramaswamy, Shri; Tschirner, Ulrike

    2009-05-01

    The key to expanding the energy supply, increasing energy security, and reducing the dependency on foreign oil is to develop advanced technologies to efficiently transform our renewable bioresources into domestically produced bioenergy and bioproducts. Conventional biorefineries, i.e., forest products industry's pulp and paper mills with long history of sustainable utilization of lignocellulose (wood), offer a suitable platform for being expanded into future integrated forest biorefineries. Due to the pre-existing infrastructure in current forest products operations, this could present a very cost-effective approach to future biorefineries. In order to better understand the overall process, technical, economic, and environmental impacts, a detailed process modeling of the whole integrated forest biorefinery is presented here. This approach uses a combination of Aspen Plus, WinGEMS, and Microsoft Excel to simulate the entire biorefinery in detail with sophisticated communication interface between the three simulations. Preliminary results for a simple case study of an integrated biorefinery show the feasibility of this approach. Further investigations, including additional details, more process options, and complete integration, are currently underway.

  9. Short-term effect of add on bell pepper (Capsicum annuum var. grossum) juice with integrated approach of yoga therapy on blood glucose levels and cardiovascular functions in patients with type 2 diabetes mellitus: A randomized controlled study.

    Science.gov (United States)

    Nagasukeerthi, Padakandla; Mooventhan, A; Manjunath, N K

    2017-10-01

    Type 2 diabetes mellitus (T2DM) is a major global health problem. Though various studies have reported the beneficial effect of Yoga in patient with T2DM, there is a lack of study in combination with bell pepper and yoga. Hence, the present study aims at evaluating short-term effect of add on bell pepper juice with integrated approach of yoga therapy (IAYT) on blood glucose levels and cardiovascular variables in patients with T2DM. Fifty T2DM subjects with the age varied from 34 to 69-years were recruited and randomly divided into either study group or control group. The study group received 100-ml of bell pepper juice (twice/day) along with IAYT while the control group received only IAYT for 4-consecutive days. Baseline and post-test assessments were taken before and after the intervention. Statistical analysis was performed using statistical package for the social sciences, version-16. Results of this study showed no significant difference in overall (fasting and post prandial) blood glucose level in the study group compared with control group. However, a significant reduction in Post prandial blood glucose (PPBG), systolic blood pressure (SBP), pulse pressure (PP), rate pressure product (RPP) and Double product (Do-P) was observed in the study group compared with control group. Results of this study suggest that though an addition of 100-ml of bell pepper juice (twice/day) along with IAYT is not more effective in reducing fasting blood glucose, it may be more effective in reducing PPBG, SBP, PP, RPP and Do-P than IAYT alone. Copyright © 2017 Elsevier Ltd. All rights reserved.

  10. Systematic Approach to Better Understanding Integration Costs: Preprint

    Energy Technology Data Exchange (ETDEWEB)

    Stark, Gregory B.

    2015-09-28

    When someone mentions integration costs, thoughts of the costs of integrating renewable generation into an existing system come to mind. We think about how variability and uncertainty can increase power system cycling costs as increasing amounts of wind or solar generation are incorporated into the generation mix. However, seldom do we think about what happens to system costs when new baseload generation is added to an existing system or when generation self-schedules. What happens when a highly flexible combined-cycle plant is added? Do system costs go up, or do they go down? Are other, non-cycling, maintenance costs impacted? In this paper we investigate six technologies and operating practices--including VG, baseload generation, generation mix, gas prices, self-scheduling, and fast-start generation--and how changes in these areas can impact a system's operating costs. This paper provides a working definition of integration costs and four components of variable costs. It describes the study approach and how a production cost modeling-based method was used to determine the cost effects, and, as a part of the study approach section, it describes the test system and data used for the comparisons. Finally, it presents the research findings, and, in closing, suggests three areas for future work.

  11. Integrals over the triplet distribution function without the triplet distribution function

    Science.gov (United States)

    Lado, F.

    While the triplet distribution function of disordered systems appears in a wide variety of problems in statistical mechanics, it does so always under an integral sign. In this paper, we propose a new method of evaluating such integrals that involves only pair functions throughout and avoids altogether the need for any explicit representation of the little-known triplet function. The procedure is based on an extension of integral equation theory of classical fluids. Numerical illustrations of the method are given for integrals that arise in the calculation of moments of a local field distribution.

  12. Necessity and approach to integrated nanomaterial legislation and governance.

    Science.gov (United States)

    Wang, Jiafan; Gerlach, John D; Savage, Nora; Cobb, George P

    2013-01-01

    Nanotechnology is one of the most promising technologies to emerge in recent decades. Materials that are specially engineered to have at least one dimension that is no larger than 100 nm are now continuously manufactured and incorporated as critical components of different products that people use daily. While we are taking advantage of nanomaterials (NMs) and nano-products, they may pose a risk to humans and the broader environment. Some types of fibrous NMs such as carbon nanotubes and nano-fibers may present a risk similar to that of asbestos. Some carbon or metal based NMs may threaten the environment due to their bioaccumulative nature within food webs. In order to prevent future adverse effects from products or byproducts of nanotechnology, we suggest an integrated multi-faceted approach which includes an integrated regulation that is based upon life cycle assessment, empirically derived risk assessment. Advanced research that fills the knowledge gap regarding the understanding of NMs in scientific and social norms will be helpful in a full life cycle assessment of NMs. Emphasizing nanotechnology education to the public for an increased understanding and participation associated with media coverage will finally draw governments' attention with an integrated legislation to be instituted. Developing the optimal mix of these tools, including research, public education, media coverage, integrated legislation, will be significant to proactively manage the complexity of nanotechnology and prevent any undesirable effect due to the NMs exposure.

  13. A liberation psychology approach to acculturative integration of migrant populations.

    Science.gov (United States)

    García-Ramírez, Manuel; de la Mata, Manuel L; Paloma, Virginia; Hernández-Plaza, Sonia

    2011-03-01

    This paper describes an acculturative integration approach that stresses the contribution of liberation psychology. Immigrant integration is a challenge for receiving countries in the Western world due to the frequent asymmetrical and oppressive conditions suffered by newcomers in their new settlements. The cross-cultural perspective connects integration with psychological acculturation, emphasizing harmony between acquisitions of the new culture while maintaining cultural heritage, and creating opportunities for intergroup relationships. In turn, liberation psychology permits an understanding of the acculturative transition as an empowerment and self-construction process by which immigrants acquire a new vision of the world and of themselves, transforming both structural conditions and themselves. From this perspective we conceptualize acculturative integration as the process by which newcomers become an accepted part of the new society through a reflexive and evaluative process, changing their social references and position, rebuilding their social and personal resources, and achieving a new agency in coherence with their new challenges and goals. In this process, they acquire critical thinking about unequal conditions, gain capacities to respond to the inequalities, and take effective actions to confront them. We illustrate this process using the narratives of nine Moroccan women who are living in asymmetrical and oppressive local contexts in Andalusia, the southern-most region of Spain.

  14. INTEGRATING THE LOGISTIC FUNCTION WITHIN ENTERPRISE’S FUNCTIONS

    Directory of Open Access Journals (Sweden)

    Cosmina Remeş

    2013-12-01

    Full Text Available Amplification and diversification of conditions in which an enterprise activates, is reflected in all the activities carried out within such. Coordination of the complex activities taking place within an enterprise requires a good management of information flows, as well as of physical flows. This situation calls for a better organization of activities within the enterprise. Taking into account that a flow implies movement of items in time and space, an issue of the utmost importance is to follow-up their trajectory within the enterprise. By grouping logistic activities within the same function, optimal management of the relationships within the enterprise, as well as interactions between such, is facilitated. Within current competitive context, characterized by a variety of customized offers, reduction of products life span, increasing requirements of the consumers who become ever more demanding, logistics occupies a key position within the continuous quest for the highest quality.

  15. A Sociology of Knowledge Approach to European Integration

    DEFF Research Database (Denmark)

    Adler-Nissen, Rebecca; Kropp, Kristoffer

    2015-01-01

    Scholars are deeply involved in the process of European integration, but we lack systematic understanding of this involvement. On the one hand, scholars, academic ideas and ideologies shape European integration and policies (e.g. the Economic and Monetary Union and the free movement of people...... and Technology Studies (STS) and political sociology, this introductory article develops a framework for studying the entanglement of EU studies with the EU around four analytical principles: (1) the principle of symmetry, (2) the principle of rejecting the internal/external division, (3) the principle...... of situatedness and (4) the principle of contextualism. A sociology of knowledge approach provides alternative explanations of the EU’s development and of our scholarly attempts to make sense of it....

  16. Libcint: An efficient general integral library for Gaussian basis functions.

    Science.gov (United States)

    Sun, Qiming

    2015-08-15

    An efficient integral library Libcint was designed to automatically implement general integrals for Gaussian-type scalar and spinor basis functions. The library is able to evaluate arbitrary integral expressions on top of p, r and σ operators with one-electron overlap and nuclear attraction, two-electron Coulomb and Gaunt operators for segmented contracted and/or generated contracted basis in Cartesian, spherical or spinor form. Using a symbolic algebra tool, new integrals are derived and translated to C code programmatically. The generated integrals can be used in various types of molecular properties. To demonstrate the capability of the integral library, we computed the analytical gradients and NMR shielding constants at both nonrelativistic and 4-component relativistic Hartree-Fock level in this work. Due to the use of kinetically balanced basis and gauge including atomic orbitals, the relativistic analytical gradients and shielding constants requires the integral library to handle the fifth-order electron repulsion integral derivatives. The generality of the integral library is achieved without losing efficiency. On the modern multi-CPU platform, Libcint can easily reach the overall throughput being many times of the I/O bandwidth. On a 20-core node, we are able to achieve an average output 8.3 GB/s for C60 molecule with cc-pVTZ basis. © 2015 Wiley Periodicals, Inc.

  17. CSR Integration into the Financial Economy: A Conceptual Approach

    Directory of Open Access Journals (Sweden)

    Georgiana - Loredana FRECEA

    2016-06-01

    Full Text Available Corporate social responsibility is a complex concept and its design integrates economic, social and environmental issues, pointing out the operational effects on a voluntary basis. It is considered a strategic point in the actual evolution of the economy, due to the financial market dynamism, being identified a critical correlation between financial crises and corporate social responsibility. The main purpose of this paper is to synthesize, through a literature review, the multiple dimensions of CSR, with a special emphasis on the theoretical approach. In order to provide a coherent overview on the banking CSR, it will be proposed a division of the CSR theories according to: (1 the ethical approach, (2 the stakeholders approach, and (3 the corporate governance approach. The major aim of this paper is to fill a gap in the theoretical approach of the CSR for the banking system, due to the necessity to unify the CSR reporting elements in order to find a balance between the bank’s organizational structure and their legitimacy to operate on the financial market.

  18. Integrative Treatment of Reflux and Functional Dyspepsia in Children

    Directory of Open Access Journals (Sweden)

    Ann Ming Yeh

    2014-08-01

    Full Text Available Gastroesophageal reflux disease (GERD and functional dyspepsia (FD are common problems in the pediatric population, with up to 7% of school-age children and up to 8% of adolescents suffering from epigastric pain, heartburn, and regurgitation. Reflux is defined as the passage of stomach contents into the esophagus, while GERD refers to reflux symptoms that are associated with symptoms or complications—such as pain, asthma, aspiration pneumonia, or chronic cough. FD, as defined by the Rome III classification, is a persistent upper abdominal pain or discomfort, not related to bowel movements, and without any organic cause, that is present for at least two months prior to diagnosis. Endoscopic examination is typically negative in FD, whereas patients with GERD may have evidence of esophagitis or gastritis either grossly or microscopically. Up to 70% of children with dyspepsia exhibit delayed gastric emptying. Treatment of GERD and FD requires an integrative approach that may include pharmacologic therapy, treating concurrent constipation, botanicals, mind body techniques, improving sleep hygiene, increasing physical activity, and traditional Chinese medicine and acupuncture.

  19. Principles and core functions of integrated child health information systems.

    Science.gov (United States)

    Hinman, Alan R; Atkinson, Delton; Diehn, Tonya Norvell; Eichwald, John; Heberer, Jennifer; Hoyle, Therese; King, Pam; Kossack, Robert E; Williams, Donna C; Zimmerman, Amy

    2004-11-01

    Infants undergo a series of preventive and therapeutic health interventions and activities. Typically, each activity includes collection and submission of data to a dedicated information system. Subsequently, health care providers, families, and health programs must query each information system to determine the child's status in a given area. Efforts are underway to integrate information in these separate information systems. This requires specifying the core functions that integrated information systems must perform.

  20. An integral representation of functions in gas-kinetic models

    Science.gov (United States)

    Perepelitsa, Misha

    2016-08-01

    Motivated by the theory of kinetic models in gas dynamics, we obtain an integral representation of lower semicontinuous functions on {{{R}}^d,} {d≥1}. We use the representation to study the problem of compactness of a family of the solutions of the discrete time BGK model for the compressible Euler equations. We determine sufficient conditions for strong compactness of moments of kinetic densities, in terms of the measures from their integral representations.

  1. Integrating Genetic Algorithm, Tabu Search Approach for Job Shop Scheduling

    CERN Document Server

    Thamilselvan, R

    2009-01-01

    This paper presents a new algorithm based on integrating Genetic Algorithms and Tabu Search methods to solve the Job Shop Scheduling problem. The idea of the proposed algorithm is derived from Genetic Algorithms. Most of the scheduling problems require either exponential time or space to generate an optimal answer. Job Shop scheduling (JSS) is the general scheduling problem and it is a NP-complete problem, but it is difficult to find the optimal solution. This paper applies Genetic Algorithms and Tabu Search for Job Shop Scheduling problem and compares the results obtained by each. With the implementation of our approach the JSS problems reaches optimal solution and minimize the makespan.

  2. Angina in a diabetic patient: a case of integrated approach

    Directory of Open Access Journals (Sweden)

    Eugenio Roberto Cosentino

    2008-09-01

    Full Text Available Diabetes mellitus, both of type 1 and 2, is an important risk factor for the development of atherosclerosis: in diabetic patients vascular atherosclerotic complications are responsible of approximately 80% of all the deaths. There is no doubt that patients affections originating from diabetes and coronaropathy remain at high risk. For this reason it is essential to adopt an aggressive strategy of secondary prevention. We report a case of a patient with multiple risk factors for cardiovascular diseases: the successful management was due to an integrated approach that involved the general practitioner and cardiologist.

  3. Integrated analytical approaches towards toxic algal natural products discovery

    DEFF Research Database (Denmark)

    Larsen, Thomas Ostenfeld; Rasmussen, Silas Anselm; Gedsted Andersen, Mikael

    demonstrated that phenotypic based chemotaxonomy can be successfully used as the intial step in selection of talented strains for testing in various bioassays, using multivariate methods for clustering of whole profiles of metabolites. The second and very important step in the discovery process...... the structures of already known compounds (3). When likely unknown compounds have been identified, we use E-SPE results (4) to predict a fast and optimal purification strategy towards the pure novel compounds for NMR characterization. This presentation will highlight our integrated analytical approaches...

  4. Integrated approach to yoga therapy and autism spectrum disorders

    Directory of Open Access Journals (Sweden)

    Shantha Radhakrishna

    2010-01-01

    Full Text Available A specially designed Integrated Approach to Yoga Therapy module was applied to Autism Spectrum Disorders over a period of two academic years. Despite low numbers (six in each arm, consistency and magnitude of effects make the findings significant. Parental participation, allowing firm guidance to be given to each child, resulted in significant improvements in imitation and other skills, and in behavior at home and family relationships. We hypothesize that guided imitation of therapist body positions stimulated mirror neuron activation, resulting in improved sense of self.

  5. Integrated Station Executive requirements and systems design approach

    Science.gov (United States)

    Berger, Eugene L.; Morris, C. Doug

    1992-01-01

    The Avionics Office of the Space Station Projects Office at Johnson Space Center (JSC) is working to define and integrate end-to-end requirements for the Space Station Freedom Program (SSFP) space-ground operations. As part of these efforts, the project office has had the MITRE Corporation perform assessments and analyses in areas where they had particular concern. These areas include the changing concepts for test methodologies, the operation and performance of the communication protocols, end-to-end network management, and the Master Objects Data Base (MODB). Since the recent restructure of the space station design, a new software application, the Integrated Station Executive (ISE), has been established. This application is to act as an executive agent along with the crew and ground controllers, while replacing (or absorbing) many of the system management functions that required a home when distributed element management was eliminated. This document summarizes the current state of the ISE requirements and assesses the characteristics of the current design. MITRE's goals in this assessment and analysis is twofold: first, identify any internal inconsistencies in either the requirements or in the current design; and second, to examine the applicability of the Open System Interconnection (OSI) management standards. Inasmuch as the ISE has been defined as the executive or operations manager application within the integrated avionics of the space station, special attention is given to adapting OSI management for the specification of the ISE functions.

  6. A design approach for integrated CMOS LC-tank oscillators using bifurcation analysis

    Directory of Open Access Journals (Sweden)

    M. Prochaska

    2006-01-01

    Full Text Available Electrical oscillators play a decisive role in integrated transceivers for wired and wireless communication systems. In this context the study of fully integrated differential VCOs has received attention. In this paper formulas for investigations of the stability as well as the amplitude of CMOS LC tank oscillators are derived, where an overall model of nonlinear gain elements is used. By means of these results we are able to present an improved design approach which gives a deeper insight into the functionality of LC tank VCOs.

  7. A Visual Interface Diagram For Mapping Functions In Integrated Products

    DEFF Research Database (Denmark)

    Ingerslev, Mattias; Oliver Jespersen, Mikkel; Göhler, Simon Moritz

    2015-01-01

    of visualizing relations between parts and functions in highly integrated mechanical products. The result is an interface diagram that supports design teams in communication, decision making and design management. The diagram gives the designer an overview of the couplings and dependencies within a product......In product development there is a recognized tendency towards increased functionality for each new product generation. This leads to more integrated and complex products, with the risk of development delays and quality issues as a consequence of lacking overview and transparency. The work described...... in this article has been conducted in collaboration with Novo Nordisk on the insulin injection device FlexTouch® as case product. The FlexTouch® reflects the characteristics of an integrated product with several functions shared between a relatively low number of parts. In this article we present a novel way...

  8. A design approach for integrating thermoelectric devices using topology optimization

    DEFF Research Database (Denmark)

    Soprani, Stefano; Haertel, Jan Hendrik Klaas; Lazarov, Boyan Stefanov;

    2016-01-01

    to operate more efficiently. This work proposes and experimentally demonstrates a topology optimization approach as a design tool for efficient integration of thermoelectric modules into systems with specific design constraints. The approach allows thermal layout optimization of thermoelectric systems....... The design method incorporates temperature dependent properties of the thermoelectric device and other materials. The3D topology optimization model developed in this work was used to design a thermoelectric system, complete with insulation and heat sink, that was produced and tested. Good agreement between...... experimental results and model forecasts was obtained and the system was able to maintain the load at more than 33 K below the oil well temperature. Results of this study support topology optimizationas a powerful design tool for thermal design of thermoelectric systems....

  9. An integrated turbocharger design approach to improve engine performance

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    Turbocharging technology is today considered as a promising way for internal combustion engine energy saving and CO2 reduction.Turbocharger design is a major challenge for turbocharged engine performance improvement.The turbocharger designer must draw upon the information of engine operation conditions,and an appropriate link between the engine requirements and design features must be carefully developed to generate the most suitable design recommendation.The objective of this research is to develop a turbocharger design approach for better turbocharger matching to an internal combustion engine.The development of the approach is based on the concept of turbocharger design and interaction links between engine cycle requirements and design parameter values.A turbocharger through flow model is then used to generate the design alternatives.This integrated method has been applied with success to a gasoline engine turbocharger assembly.

  10. Integrative Function of Knowledge in the System of the Competitive Potential of the Company

    Directory of Open Access Journals (Sweden)

    Nedka Nikolova

    2016-06-01

    Full Text Available The paper explores the integrative function of knowledge in the system of the competitive potential of the company. It argues that knowledge is the integrator of the different elements of the overall competitive potential of the company. The approach and the model of Michael Porter are analyzed in the study of knowledge as a key factor for success in the competitive struggle. The main objective is to explore approaches and models of knowledge management and best practices of their implementation in order to promote and adapt them to the conditions of Bulgarian business organizations in their striving after competitiveness increase.

  11. Auditory-Verbal Music Play Therapy: An Integrated Approach (AVMPT

    Directory of Open Access Journals (Sweden)

    Sahar Mohammad Esmaeilzadeh

    2013-10-01

    Full Text Available Introduction: Hearing loss occurs when there is a problem with one or more parts of the ear or ears and causes children to have a delay in the language-learning process. Hearing loss affects children's lives and their development. Several approaches have been developed over recent decades to help hearing-impaired children develop language skills. Auditory-verbal therapy (AVT is one such approach. Recently, researchers have found that music and play have a considerable effect on the communication skills of children, leading to the development of music therapy (MT and play therapy (PT. There have been several studies which focus on the impact of music on hearing-impaired children. The aim of this article is to review studies conducted in AVT, MT, and PT and their efficacy in hearing-impaired children. Furthermore, the authors aim to introduce an integrated approach of AVT, MT, and PT which facilitates language and communication skills in hearing-impaired children.   Materials and Methods: In this article we review studies of AVT, MT, and PT and their impact on hearing-impaired children. To achieve this goal, we searched databases and journals including Elsevier, Chor Teach, and Military Psychology, for example. We also used reliable websites such as American Choral Directors Association and Joint Committee on Infant Hearing websites. The websites were reviewed and key words in this article used to find appropriate references. Those articles which are related to ours in content were selected.    Results: Recent technologies have brought about great advancement in the field of hearing disorders. Now these impairments can be detected at birth, and in the majority of cases, hearing impaired children can develop fluent spoken language through audition. According to researches on the relationship between hearing impaired children’s communication and language skills and different approaches of therapy, it is known that learning through listening and

  12. An integrated approach to the design of an aircraft gain scheduled controller

    OpenAIRE

    Berglund, Erik

    1995-01-01

    This thesis addresses the problem of integrated design of the aircraft plant parameters and of the corresponding feedback controller. The plant parameters are typically the sizes of the control surfaces or other aerodynamical surfaces of the aircraft. The approach is to rewrite the aircraft dynamic requirements as linear matrix inequalities (LMI's) and to optimize a linear cost function associated with aircraft plant parameters, while meeting the LMI constraints. An algorithm using Matlab and...

  13. Botulinum toxin type A treatment of cerebral palsy: an integrated approach

    OpenAIRE

    Molenaers, Guy; Desloovere, Kaat; Eyssen, M; De Cat, Josse; Jonkers, Ilse; De Cock, Paul

    1999-01-01

    We have applied a multilevel approach no the management of spasticity associated with cerebral palsy (CP). All of the following factors are important in forming an integrated strategy for botulinum toxin type A (BTX-A) therapy: the timing of injections, patient selection, multilevel BTS-A treatment, optimal dosage and injection technique, follow-up treatment and objective measurements of functional outcome. Data on all these factors are presented here. CP patients had a mean age of 6.5 years ...

  14. Information security architecture an integrated approach to security in the organization

    CERN Document Server

    Killmeyer, Jan

    2000-01-01

    An information security architecture is made up of several components. Each component in the architecture focuses on establishing acceptable levels of control. These controls are then applied to the operating environment of an organization. Functionally, information security architecture combines technical, practical, and cost-effective solutions to provide an adequate and appropriate level of security.Information Security Architecture: An Integrated Approach to Security in the Organization details the five key components of an information security architecture. It provides C-level executives

  15. Introducing Linear Functions: An Alternative Statistical Approach

    Science.gov (United States)

    Nolan, Caroline; Herbert, Sandra

    2015-01-01

    The introduction of linear functions is the turning point where many students decide if mathematics is useful or not. This means the role of parameters and variables in linear functions could be considered to be "threshold concepts". There is recognition that linear functions can be taught in context through the exploration of linear…

  16. Integrating medical and research information: a big data approach.

    Science.gov (United States)

    Tilve Álvarez, Carlos M; Ayora Pais, Alberto; Ruíz Romero, Cristina; Llamas Gómez, Daniel; Carrajo García, Lino; Blanco García, Francisco J; Vázquez González, Guillermo

    2015-01-01

    Most of the information collected in different fields by Instituto de Investigación Biomédica de A Coruña (INIBIC) is classified as unstructured due to its high volume and heterogeneity. This situation, linked to the recent requirement of integrating it to the medical information, makes it necessary to implant specific architectures to collect and organize it before it can be analysed. The purpose of this article is to present the Hadoop framework as a solution to the problem of integrating research information in the Business Intelligence field. This framework can collect, explore, process and structure the aforementioned information, which allow us to develop an equivalent function to a data mart in an Intelligence Business system.

  17. A recursive approach to the reduction of tensor Feynman integrals

    CERN Document Server

    Diakonidis, Theodoros; Riemann, Tord; Tausk, Bas

    2010-01-01

    We describe a new, convenient, recursive tensor integral reduction scheme for one-loop $n$-point Feynman integrals. The reduction is based on the algebraic Davydychev-Tarasov formalism where the tensors are represented by scalars with shifted dimensions and indices, and then expressed by conventional scalars with generalized recurrence relations. The scheme is worked out explicitly for up to $n=6$ external legs and for tensor ranks $R\\leq n$. The tensors are represented by scalar one- to four-point functions in $d$ dimensions. For the evaluation of them, the Fortran code for the tensor reductions has to be linked with a package like QCDloop or LoopTools/FF. Typical numerical results are presented.

  18. Expansion of a class of functions into an integral involving associated Legendre functions

    Directory of Open Access Journals (Sweden)

    Nanigopal Mandal

    1994-01-01

    Full Text Available A theorem for expansion of a class of functions into an integral involving associated Legendre functions is obtained in this paper. This is a somewhat general integral expansion formula for a function f(x defined in (x1,x2 where -1

  19. Integrated Justice: An Information Systems Approach to Justice Sector Case Management and Information Sharing

    Directory of Open Access Journals (Sweden)

    Adam Curtis Watson

    2017-07-01

    Full Text Available Automated Case Management Systems are still at an early stage of adoption in many developing countries. These are frequently standalone systems implemented with donor financing, and they often fail due to capacity constraints or as a consequence of short-term, project-based funding. But there are examples of developing countries overcoming these pitfalls and producing innovative solutions that surpass government practices in more developed countries. The Integrated Electronic Case Management System (IECMS, developed and implemented by the Ministry of Justice of Rwanda from 2015-2016, is one such innovation. This system has progressed rapidly in its level of adoption and integration between law enforcement, the prosecutor’s office, courts, and corrections. This paper will discuss the key system functionalities and the implementation methodology, including both the benefits and shortcomings of this approach, with the goal of applying lessons learned in future installations. Foremost among the successes of this project were the integrated Sector Wide Approach, the thorough business process re-engineering, and strong ownership by the Rwandan Justice Sector staff. Particularly instructive will be the analysis of the integrated approach, covering five institutions with a single system in less than two years. However, the particular success in this case may not be replicable for governments with a more decentralized approach.

  20. Clinical Assessment of Risk Management: an INtegrated Approach (CARMINA).

    Science.gov (United States)

    Tricarico, Pierfrancesco; Tardivo, Stefano; Sotgiu, Giovanni; Moretti, Francesca; Poletti, Piera; Fiore, Alberto; Monturano, Massimo; Mura, Ida; Privitera, Gaetano; Brusaferro, Silvio

    2016-08-08

    Purpose - The European Union recommendations for patient safety calls for shared clinical risk management (CRM) safety standards able to guide organizations in CRM implementation. The purpose of this paper is to develop a self-evaluation tool to measure healthcare organization performance on CRM and guide improvements over time. Design/methodology/approach - A multi-step approach was implemented including: a systematic literature review; consensus meetings with an expert panel from eight Italian leader organizations to get to an agreement on the first version; field testing to test instrument feasibility and flexibility; Delphi strategy with a second expert panel for content validation and balanced scoring system development. Findings - The self-assessment tool - Clinical Assessment of Risk Management: an INtegrated Approach includes seven areas (governance, communication, knowledge and skills, safe environment, care processes, adverse event management, learning from experience) and 52 standards. Each standard is evaluated according to four performance levels: minimum; monitoring; outcomes; and improvement actions, which resulted in a feasible, flexible and valid instrument to be used throughout different organizations. Practical implications - This tool allows practitioners to assess their CRM activities compared to minimum levels, monitor performance, benchmarking with other institutions and spreading results to different stakeholders. Originality/value - The multi-step approach allowed us to identify core minimum CRM levels in a field where no consensus has been reached. Most standards may be easily adopted in other countries.

  1. METHODOLOGICAL APPROACHES TO ASSESSING THE EFFICIENCY OF THE INTEGRATION UNITS

    Directory of Open Access Journals (Sweden)

    I. P. Bogomolova

    2014-01-01

    Full Text Available The article examines the scientific and methodological apparatus assessment, built on the basis of the categories of «effectiveness» and «optimality», will allow, on the one hand, to establish the efficiency of functioning of associations in prior periods, on the other - to identify the parameters conditioning condition and results of integrated production in the future. Taking into account the results of these studies, we developed a methodology of integrated assessment of efficiency of functioning of the agro-industrial units. Its essence consists in the determination of the integral coefficient of efficiency on the basis of two complementary groups of settings: performance, expressed in the system of relative indicators, and optimality, the quantitative characteristics of which used the limit values. As the distinctive features of the proposed methodology, determining its scientific novelty and practical significance, it should be noted: enabling the assessment of the effectiveness in using existing and advanced involved in production resources; the use of a unified system of criteria and performance measures and to determine the level of optimality of meat production, built in accordance with the sequence of stages of the reproduction process; universality settlement mechanism, used for the analysis of efficiency of managing the links of the production chain (agriculture, processing, trade and overall integration. The technique involves the execution of the aggregate calculation and analytical operations, grouped by us in the framework of interrelated stages. The result can be identified priority directions of development of the Association, the necessity to optimize the composition of participants and proportions of the process chain, development and implementation of innovative programs, development of new technologies and management methods.

  2. Identification of ovarian cancer associated genes using an integrated approach in a Boolean framework

    Science.gov (United States)

    2013-01-01

    Background Cancer is a complex disease where molecular mechanism remains elusive. A systems approach is needed to integrate diverse biological information for the prognosis and therapy risk assessment using mechanistic approach to understand gene interactions in pathways and networks and functional attributes to unravel the biological behaviour of tumors. Results We weighted the functional attributes based on various functional properties observed between cancerous and non-cancerous genes reported from literature. This weighing schema was then encoded in a Boolean logic framework to rank differentially expressed genes. We have identified 17 genes to be differentially expressed from a total of 11,173 genes, where ten genes are reported to be down-regulated via epigenetic inactivation and seven genes are up-regulated. Here, we report that the overexpressed genes IRAK1, CHEK1 and BUB1 may play an important role in ovarian cancer. We also show that these 17 genes can be used to form an ovarian cancer signature, to distinguish normal from ovarian cancer subjects and that the set of three genes, CHEK1, AR, and LYN, can be used to classify good and poor prognostic tumors. Conclusion We provided a workflow using a Boolean logic schema for the identification of differentially expressed genes by integrating diverse biological information. This integrated approach resulted in the identification of genes as potential biomarkers in ovarian cancer. PMID:23383610

  3. An Integral-Direct Linear-Scaling Second-Order Møller-Plesset Approach.

    Science.gov (United States)

    Nagy, Péter R; Samu, Gyula; Kállay, Mihály

    2016-10-11

    An integral-direct, iteration-free, linear-scaling, local second-order Møller-Plesset (MP2) approach is presented, which is also useful for spin-scaled MP2 calculations as well as for the efficient evaluation of the perturbative terms of double-hybrid density functionals. The method is based on a fragmentation approximation: the correlation contributions of the individual electron pairs are evaluated in domains constructed for the corresponding localized orbitals, and the correlation energies of distant electron pairs are computed with multipole expansions. The required electron repulsion integrals are calculated directly invoking the density fitting approximation; the storage of integrals and intermediates is avoided. The approach also utilizes natural auxiliary functions to reduce the size of the auxiliary basis of the domains and thereby the operation count and memory requirement. Our test calculations show that the approach recovers 99.9% of the canonical MP2 correlation energy and reproduces reaction energies with an average (maximum) error below 1 kJ/mol (4 kJ/mol). Our benchmark calculations demonstrate that the new method enables MP2 calculations for molecules with more than 2300 atoms and 26000 basis functions on a single processor.

  4. Optimizing Groundwater Monitoring Networks Using Integrated Statistical and Geostatistical Approaches

    Directory of Open Access Journals (Sweden)

    Jay Krishna Thakur

    2015-08-01

    Full Text Available The aim of this work is to investigate new approaches using methods based on statistics and geo-statistics for spatio-temporal optimization of groundwater monitoring networks. The formulated and integrated methods were tested with the groundwater quality data set of Bitterfeld/Wolfen, Germany. Spatially, the monitoring network was optimized using geo-statistical methods. Temporal optimization of the monitoring network was carried out using Sen’s method (1968. For geostatistical network optimization, a geostatistical spatio-temporal algorithm was used to identify redundant wells in 2- and 2.5-D Quaternary and Tertiary aquifers. Influences of interpolation block width, dimension, contaminant association, groundwater flow direction and aquifer homogeneity on statistical and geostatistical methods for monitoring network optimization were analysed. The integrated approach shows 37% and 28% redundancies in the monitoring network in Quaternary aquifer and Tertiary aquifer respectively. The geostatistical method also recommends 41 and 22 new monitoring wells in the Quaternary and Tertiary aquifers respectively. In temporal optimization, an overall optimized sampling interval was recommended in terms of lower quartile (238 days, median quartile (317 days and upper quartile (401 days in the research area of Bitterfeld/Wolfen. Demonstrated methods for improving groundwater monitoring network can be used in real monitoring network optimization with due consideration given to influencing factors.

  5. Tackling burden in ART: an integrated approach for medical staff.

    Science.gov (United States)

    Boivin, Jacky; Domar, Alice D; Shapiro, Daniel B; Wischmann, Tewes H; Fauser, Bart C J M; Verhaak, Christianne

    2012-04-01

    Discontinuation is a problem in fertility clinics. Many couples discontinue assisted reproductive technologies (ART) without achieving a live birth for reasons other than poor prognosis or the cost of treatment. Discontinuation has been attributed to the burden of treatment. The causes of burden can be broadly classified according to whether they originate in the patient, clinic or treatment. Interventions to alleviate these burdens include provision of comprehensive educational material, screening to identify highly distressed patients, provision of tailored coping tools and improvements in the clinic environment and medical interventions. Practical interventions to reduce the different causes of burden in ART exist, but further development and evaluation of the efficacy of these interventions requires more precise definition of terms and theory. In this paper, we propose a general integrated approach to cover different perspectives in dealing with burden in ART clinics. We firstly describe the integrated approach and present common sources of burden. We then describe interventions that could help reduce the burden in ART. Our paper is aimed at fertility clinic staff because of their day-to-day involvement with patients. However, this discussion should also be relevant to companies that develop treatments and to psychosocial experts. Reducing the burden of treatment should lead to improved outcomes, namely better quality of life during treatment and lower discontinuation rates.

  6. A hybrid approach to device integration on a genetic analysis platform

    Science.gov (United States)

    Brennan, Des; Jary, Dorothee; Kurg, Ants; Berik, Evgeny; Justice, John; Aherne, Margaret; Macek, Milan; Galvin, Paul

    2012-10-01

    Point-of-care (POC) systems require significant component integration to implement biochemical protocols associated with molecular diagnostic assays. Hybrid platforms where discrete components are combined in a single platform are a suitable approach to integration, where combining multiple device fabrication steps on a single substrate is not possible due to incompatible or costly fabrication steps. We integrate three devices each with a specific system functionality: (i) a silicon electro-wetting-on-dielectric (EWOD) device to move and mix sample and reagent droplets in an oil phase, (ii) a polymer microfluidic chip containing channels and reservoirs and (iii) an aqueous phase glass microarray for fluorescence microarray hybridization detection. The EWOD device offers the possibility of fully integrating on-chip sample preparation using nanolitre sample and reagent volumes. A key challenge is sample transfer from the oil phase EWOD device to the aqueous phase microarray for hybridization detection. The EWOD device, waveguide performance and functionality are maintained during the integration process. An on-chip biochemical protocol for arrayed primer extension (APEX) was implemented for single nucleotide polymorphism (SNiP) analysis. The prepared sample is aspirated from the EWOD oil phase to the aqueous phase microarray for hybridization. A bench-top instrumentation system was also developed around the integrated platform to drive the EWOD electrodes, implement APEX sample heating and image the microarray after hybridization.

  7. Functional approaches in translation studies in Germany Functional approaches in translation studies in Germany

    Directory of Open Access Journals (Sweden)

    Paul Kussmaul

    2008-04-01

    Full Text Available In the early phase of translation studies in Germany, contrastive linguistics played a major role. I shall briefly describe this approach so that the functional approach will become clearer by contrast. Influenced by the representatives of stylistique comparée, Vinay/Darbelnet (1968 Wolfram Wilss, for instance, in his early work (1971, 1977 makes frequent use of the notion transposition (German “Ausdrucksverschiebung“, cf. also Catford’s (1965 term shift. As a whole, of course, Wilss’ work has a much broader scope. More recently, he has investigated the role of cognition (1988 and the various factors in translator behaviour (1996. Nevertheless, transposition is still a very important and useful notion in describing the translation process. The need for transpositions arises when there is no possibility of formal one-to-one correspondence between source and target-language structures. The basic idea is that whenever there is a need for transposition, we are faced with a translation problem. In the early phase of translation studies in Germany, contrastive linguistics played a major role. I shall briefly describe this approach so that the functional approach will become clearer by contrast. Influenced by the representatives of stylistique comparée, Vinay/Darbelnet (1968 Wolfram Wilss, for instance, in his early work (1971, 1977 makes frequent use of the notion transposition (German “Ausdrucksverschiebung“, cf. also Catford’s (1965 term shift. As a whole, of course, Wilss’ work has a much broader scope. More recently, he has investigated the role of cognition (1988 and the various factors in translator behaviour (1996. Nevertheless, transposition is still a very important and useful notion in describing the translation process. The need for transpositions arises when there is no possibility of formal one-to-one correspondence between source and target-language structures. The basic idea is that whenever there is a need for

  8. On Parameter Differentiation for Integral Representations of Associated Legendre Functions

    Directory of Open Access Journals (Sweden)

    Howard S. Cohl

    2011-05-01

    Full Text Available For integral representations of associated Legendre functions in terms of modified Bessel functions, we establish justification for differentiation under the integral sign with respect to parameters. With this justification, derivatives for associated Legendre functions of the first and second kind with respect to the degree are evaluated at odd-half-integer degrees, for general complex-orders, and derivatives with respect to the order are evaluated at integer-orders, for general complex-degrees. We also discuss the properties of the complex function f: C{−1,1}→C given by f(z=z/((z+1^{1/2}(z−1^{1/2}.

  9. Density Functional Approach Based on Numerically Obtained Bridge Functional

    Institute of Scientific and Technical Information of China (English)

    ZHOUShi-Qi

    2002-01-01

    The ornstein-zenike equation is solved with the Rogers-Young approximation for bulk hard sphere fluid and Lennard-Jones fluid for several state points.Then the resulted bulk fluid radial distribution function combined with the test particle method is employed to determine numerically the function relationship of bridge functional as a function of indirect correlation function.It is found that all of the calculated points from different phase space state points for a same type of fluid collapse onto a same smooth curve.Then the numerically obtained curve is used to substitute the analytic expression of the bridge functional as a function of indirect correlation function required in the methodology [J.Chem.Phys,112(2000)8079] to determine the density distribution of non-uniform hard sphere fluid and Lennard-Jones fluid.The good agreement of theoretical predictions with the computer simulation data is obtained.The present numerical procedure incroporates the knowledge of bulk fluid radial distribution function into the constructing of the density functional approximation and makes the original methodology more accurate and more filexible for various interaction potential fluid.

  10. Microbes Online: an integrated portal for comparative functional genomics

    OpenAIRE

    Arkin, Adam P.

    2014-01-01

    Since 2003, MicrobesOnline (http://www.microbesonline.org) has been providing a community resource for comparative and functional genome analysis. The portal includes over 1000 complete genomes of bacteria, archaea and fungi, as well as 1000s of viruses and plasmids. In addition to standard comparative genomic analysis, including gene prediction, sequence homology, domain identification, gene family assignments and functional annotations from E.C. and GO, MicrobesOnline integrates data from ...

  11. Integrated process and dual-function catalyst for olefin epoxidation

    Science.gov (United States)

    Zhou, Bing; Rueter, Michael

    2003-01-01

    The invention discloses a dual-functional catalyst composition and an integrated process for production of olefin epoxides including propylene oxide by catalytic reaction of hydrogen peroxide from hydrogen and oxygen with olefin feeds such as propylene. The epoxides and hydrogen peroxide are preferably produced simultaneously in situ. The dual-functional catalyst comprises noble metal crystallites with dimensions on the nanometer scale (on the order of olefin oxides such as propylene oxide without formation of undesired co-products.

  12. Reexamination of molecular integrals arising from the Dirac equation. Analytical evaluation of molecular auxiliary functions integrals

    OpenAIRE

    Bagci, A.

    2016-01-01

    In this work, analytical solutions to relativistic molecular integrals are proposed for use in ab-initio molecular electronic structure calculations. They are expressed through molecular auxiliary functions integrals in prolate spheroidal coordinates. Recurrence relations and new convergent series representation formulae are derived. They involve Slater-type orbitals basis set with non-integer principal quantum numbers. The comparison is made with the benchmark results of use numerical global...

  13. A Functional Analytic Approach to Group Psychotherapy

    Science.gov (United States)

    Vandenberghe, Luc

    2009-01-01

    This article provides a particular view on the use of Functional Analytical Psychotherapy (FAP) in a group therapy format. This view is based on the author's experiences as a supervisor of Functional Analytical Psychotherapy Groups, including groups for women with depression and groups for chronic pain patients. The contexts in which this approach…

  14. Angiography and coronary function, a clinical approach

    NARCIS (Netherlands)

    Stoel, Martin Gerrit

    2013-01-01

    Coronary angiography has the potential to determine coronary function in addition to merely showing coronary anatomy. In this thesis, we describe several facets of angiographic evaluation of coronary flow velocity and function. Measurement of the length of the coronary vessels by means of a guide

  15. Social Integration and Functional Skills in Older Adults

    Directory of Open Access Journals (Sweden)

    Diana María Durán

    2008-05-01

    Full Text Available The objective of this study is to identify the relationship between variables: functional abilities and social integration of older persons and to know whether there were differences according to sex, age and marital status. The results show significant differences in social integration on the basis of marital status, being higher in the elderly unmarried and widowed; Depending on age there are significant differences in functional abilities, being higher in adults between 60 and 65 years. There were no significant differences according to sex. The conclusion is that the autonomy andfunctional abilities of the Elderly are closely related to the frequency of physical activities and social integration, which promotes the quality of life of older people and hampering the emergence of significant biopsychosocial changes in this stage of life.

  16. Integral operators in non-standard function spaces

    CERN Document Server

    Kokilashvili, Vakhtang; Rafeiro, Humberto; Samko, Stefan

    2016-01-01

    This book, the result of the authors’ long and fruitful collaboration, focuses on integral operators in new, non-standard function spaces and presents a systematic study of the boundedness and compactness properties of basic, harmonic analysis integral operators in the following function spaces, among others: variable exponent Lebesgue and amalgam spaces, variable Hölder spaces, variable exponent Campanato, Morrey and Herz spaces, Iwaniec-Sbordone (grand Lebesgue) spaces, grand variable exponent Lebesgue spaces unifying the two spaces mentioned above, grand Morrey spaces, generalized grand Morrey spaces, and weighted analogues of some of them. The results obtained are widely applied to non-linear PDEs, singular integrals and PDO theory. One of the book’s most distinctive features is that the majority of the statements proved here are in the form of criteria. The book is intended for a broad audience, ranging from researchers in the area to experts in applied mathematics and prospective students.

  17. Method of folding a piecewise polynomial function in the delta function integral representation

    Energy Technology Data Exchange (ETDEWEB)

    Lee, D.K.

    1978-12-01

    A simple procedure is presented for determining the folded form of a piecewise polynomial function in the delta function integral representation. The procedure is useful in evaluating the autocorrelation function by means of the algebraic convolution technique developed by Polge and Hasy (IEEE Trans. Comput. pp. 970-975, Nov 1973).

  18. Density Functional Approach Based on Numerically Obtained Bridge Functional

    Institute of Scientific and Technical Information of China (English)

    ZHOU Shi-Qi

    2002-01-01

    The Ornstein Zernike equation is solved with the Rogers Young approximation for bulk hard sphere fluidand Lennard-Jones fluid for several state points. Then the resulted bulk fluid radial distribution function combinedwith the test particle method is employed to determine numerically the function relationship of bridge functional as afunction of indirect correlation function. It is found that all of the calculated points from different phase space statepoints for a same type of fluid collapse onto a same smooth curve. Then the numerically obtained curve is used tosubstitute the analytic expression of the bridge functional as a function of indirect correlation function required in themethodology [J. Chem. Phys. 112 (2000) 8079] to deterrnine the density distribution of non-uniform hard spherefluid and Lennard Jones fluid. The good agreement of theoretical predictions with the computer simulation data isobtained. The present numerical procedure incorporates the knowledge of bulk fluid radial distribution function intothe constructing of the density functional approximation and makes the original methodology more accurate and moreflexible for various interaction potential fluid.

  19. Subordination and superordination for certain analytic functions containing fractional integral

    Directory of Open Access Journals (Sweden)

    Shaher Momani

    2009-11-01

    Full Text Available The purpose of the present article is to derive some subordination and superordination results for certain normalized analytic functions involving fractional integral operator. Moreover, this result is applied to find a relation between univalent solutions for fractional differential equation.

  20. Invention software support by integrating function and mathematical modeling

    NARCIS (Netherlands)

    Chechurin, L.S.; Wits, Wessel Willems; Bakker, H.M.

    2015-01-01

    New idea generation is imperative for successful product innovation and technology development. This paper presents the development of a novel type of invention support software. The support tool integrates both function modeling and mathematical modeling, thereby enabling quantitative analyses on a

  1. Invention software support by integrating function and mathematical modeling

    NARCIS (Netherlands)

    Chechurin, L.S.; Wits, W.W.; Bakker, H.M.

    2015-01-01

    New idea generation is imperative for successful product innovation and technology development. This paper presents the development of a novel type of invention support software. The support tool integrates both function modeling and mathematical modeling, thereby enabling quantitative analyses on a

  2. Integrative pathway genomics of lung function and airflow obstruction

    NARCIS (Netherlands)

    Gharib, Sina A.; Loth, Daan W.; Artigas, Maria Soler; Birkland, Timothy P.; Wilk, Jemma B.; Wain, Louise V.; Brody, Jennifer A.; Obeidat, Ma'en; Hancock, Dana B.; Tang, Wenbo; Rawal, Rajesh; Boezen, H. Marike; Imboden, Medea; Huffman, Jennifer E.; Lahousse, Lies; Alves, Alexessander C.; Manichaikul, Ani; Hui, Jennie; Morrison, Alanna C.; Ramasamy, Adaikalavan; Smith, Albert Vernon; Gudnason, Vilmundur; Surakka, Ida; Vitart, Veronique; Evans, David M.; Strachan, David P.; Deary, Ian J.; Hofman, Albert; Glaeser, Sven; Wilson, James F.; North, Kari E.; Zhao, Jing Hua; Heckbert, Susan R.; Jarvis, Deborah L.; Probst-Hensch, Nicole; Schulz, Holger; Barr, R. Graham; Jarvelin, Marjo-Riitta; O'Connor, George T.; Kahonen, Mika; Cassano, Patricia A.; Hysi, Pirro G.; Dupuis, Josee; Hayward, Caroline; Psaty, Bruce M.; Hall, Ian P.; Parks, William C.; Tobin, Martin D.; London, Stephanie J.

    2015-01-01

    Chronic respiratory disorders are important contributors to the global burden of disease. Genome-wide association studies (GWASs) of lung function measures have identified several trait-associated loci, but explain only a modest portion of the phenotypic variability. We postulated that integrating p

  3. Dyspraxia, motor function and visual-motor integration in autism.

    Science.gov (United States)

    Miller, M; Chukoskie, L; Zinni, M; Townsend, J; Trauner, D

    2014-08-01

    This project assessed dyspraxia in high-functioning school aged children with autism with a focus on Ideational Praxis. We examined the association of specific underlying motor function including eye movement with ideational dyspraxia (sequences of skilled movements) as well as the possible role of visual-motor integration in dyspraxia. We found that compared to IQ-, sex- and age-matched typically developing children, the children with autism performed significantly worse on: Ideational and Buccofacial praxis; a broad range of motor tests, including measures of simple motor skill, timing and accuracy of saccadic eye movements and motor coordination; and tests of visual-motor integration. Impairments in individual children with autism were heterogeneous in nature, although when we examined the praxis data as a function of a qualitative measure representing motor timing, we found that children with poor motor timing performed worse on all praxis categories and had slower and less accurate eye movements while those with regular timing performed as well as typical children on those same tasks. Our data provide evidence that both motor function and visual-motor integration contribute to dyspraxia. We suggest that dyspraxia in autism involves cerebellar mechanisms of movement control and the integration of these mechanisms with cortical networks implicated in praxis.

  4. Functional Integrals and Collective Excitations in Boson-Fermion Model

    Institute of Scientific and Technical Information of China (English)

    YAN Jun

    2006-01-01

    In this paper, collective excitations in the boson-fermion model are investigated by means of functional integration method. The equations of energy gap and excitation spectrum are derived. Moreover, the Bose energy spectrum of zero wave vector Fermi fields is also calculated.

  5. Modularization, inter-functional integration and operational performance

    DEFF Research Database (Denmark)

    Boer, Henrike Engele Elisabeth; Boer, Harry

    2014-01-01

    for firms to indeed use product modularity beneficially, in particular inter-functional integration between manufacturing and purchasing, design and sales, respectively. The purpose of the paper is to investigate the direct performance effects of modularization, as well as the mediating effects of the three...

  6. Exact results for one dimensional fluids through functional integration

    CERN Document Server

    Fantoni, Riccardo

    2016-01-01

    We review some of the exactly solvable one dimensional continuum fluid models of equilibrium classical statistical mechanics under the unified setting of functional integration in one dimension. We make some further developments and remarks concerning fluids with penetrable particles. We then apply our developments to the study of the Gaussian core model for which we are unable to find a well defined thermodynamics.

  7. Finding Practical Approaches to Integrated Water Resources Management

    Directory of Open Access Journals (Sweden)

    John Butterworth

    2010-02-01

    Full Text Available Integrated Water Resources Management (IWRM has often been interpreted and implemented in a way that is only really suited to countries with the most developed water infrastructures and management capacities. While sympathetic to many of the criticisms levelled at the IWRM concept and recognising the often disappointing levels of adoption, this paper and the series of papers it introduces identify some alternative ways forward in a developmental context that place more emphasis on the practical in-finding solutions to water scarcity. A range of lighter, more pragmatic and context-adapted approaches, strategies and entry points are illustrated with examples from projects and initiatives in mainly 'developing' countries. The authors argue that a more service-orientated (WASH, irrigation and ecosystem services, locally rooted and balanced approach to IWRM that better matches contexts and capacities should build on such strategies, in addition to the necessary but long-term policy reforms and river basin institution-building at higher levels. Examples in this set of papers not only show that the 'lighter', more opportunistic and incremental approach has potential as well as limitations but also await wider piloting and adoption.

  8. Adaptive XML to relational mapping: an integrated approach

    Institute of Scientific and Technical Information of China (English)

    Tian-lei HU; Gang CHEN

    2008-01-01

    Storing and querying XML (eXtensible Markup Language) data in relational form can exploit various services offered by modem relational database management systems (RDBMSs). Due to structural complexity of XML, there are many equivalent relational mapping schemes for the same XML data and queries. In this paper, we propose the adaptive XML to relational mapping (AX2RM) system, which considers finding optimal XML to relational (X2R) mapping as four separate but correlated procedures: logical database design, data scale estimation, workload transformation, and physical database design. We view the whole process as an autonomic computing problem and formalize the adaptive X2R mapping problem. Search spaces for each procedure are investigated individually, and five approaches for finding the optimal mapping are studied. We propose an integrated approach with greedy pruning (IT-GP), which views the mapping procedures as a whole and exploits heuristic rules in each procedure to prune impossible mappings as early as possible. Evaluation of these approaches shows the validity and high efficiency of IT-GP.

  9. Contingent approach to Internet-based supply network integration

    Science.gov (United States)

    Ho, Jessica; Boughton, Nick; Kehoe, Dennis; Michaelides, Zenon

    2001-10-01

    The Internet is playing an increasingly important role in enhancing the operations of supply networks as many organizations begin to recognize the benefits of Internet- enabled supply arrangements. However, the developments and applications to-date do not extend significantly beyond the dyadic model, whereas the real advantages are to be made with the external and network models to support a coordinated and collaborative based approach. The DOMAIN research group at the University of Liverpool is currently defining new Internet- enabled approaches to enable greater collaboration across supply chains. Different e-business models and tools are focusing on different applications. Using inappropriate e- business models, tools or techniques will bring negative results instead of benefits to all the tiers in the supply network. Thus there are a number of issues to be considered before addressing Internet based supply network integration, in particular an understanding of supply chain management, the emergent business models and evaluating the effects of deploying e-business to the supply network or a particular tier. It is important to utilize a contingent approach to selecting the right e-business model to meet the specific supply chain requirements. This paper addresses the issues and provides a case study on the indirect materials supply networks.

  10. In Search of an Integrative Measure of Functioning

    Directory of Open Access Journals (Sweden)

    Rosamond H. Madden

    2015-05-01

    Full Text Available International trends towards people-centred, integrative care and support require any measurement of functioning and disability to meet multiple aims. The information requirements of two major Australian programs for disability and rehabilitation are outlined, and the findings of two searches for suitable measures of functioning and disability are analysed. Over 30 current measures of functioning were evaluated in each search. Neither search found a generic measure of functioning suitable for these multibillion dollar programs, relevant to a wide range of people with a variety of health conditions and functioning experiences, and capable of indicating support needs, associated costs, progress and outcomes. This unsuccessful outcome has implications internationally for policy-relevant information for disability, rehabilitation and related programs. The paper outlines the features of an Integrative Measure of Functioning (IMF based on the concepts of functioning and environmental factors in the International Classification of Functioning, Disability and Health (ICF. An IMF would be applicable across a variety of health conditions, settings and purposes, ranging from individual assessment to public health. An IMF could deliver person-centred, policy-relevant information for a range of programs, promoting harmonised language and measurement and supporting international trends in human services and public health.

  11. The modular and integrative functional architecture of the human brain.

    Science.gov (United States)

    Bertolero, Maxwell A; Yeo, B T Thomas; D'Esposito, Mark

    2015-12-01

    Network-based analyses of brain imaging data consistently reveal distinct modules and connector nodes with diverse global connectivity across the modules. How discrete the functions of modules are, how dependent the computational load of each module is to the other modules' processing, and what the precise role of connector nodes is for between-module communication remains underspecified. Here, we use a network model of the brain derived from resting-state functional MRI (rs-fMRI) data and investigate the modular functional architecture of the human brain by analyzing activity at different types of nodes in the network across 9,208 experiments of 77 cognitive tasks in the BrainMap database. Using an author-topic model of cognitive functions, we find a strong spatial correspondence between the cognitive functions and the network's modules, suggesting that each module performs a discrete cognitive function. Crucially, activity at local nodes within the modules does not increase in tasks that require more cognitive functions, demonstrating the autonomy of modules' functions. However, connector nodes do exhibit increased activity when more cognitive functions are engaged in a task. Moreover, connector nodes are located where brain activity is associated with many different cognitive functions. Connector nodes potentially play a role in between-module communication that maintains the modular function of the brain. Together, these findings provide a network account of the brain's modular yet integrated implementation of cognitive functions.

  12. Linking Science and Language Arts: A Review of the Literature Which Compares Integrated versus Non-Integrated Approaches

    Science.gov (United States)

    Bradbury, Leslie U.

    2014-01-01

    The purpose of this paper is to review the literature published during the last 20 years that investigates the impact of approaches that describe themselves as integrating science and language arts on student learning and/or attitude at the elementary level. The majority of papers report that integrated approaches led to greater student…

  13. The microRNA body map: dissecting microRNA function through integrative genomics

    OpenAIRE

    Mestdagh, Pieter; Lefever, Steve; Pattyn, Filip; Ridzon, Dana; Fredlund, Erik; Fieuw, Annelies; Ongenaert, Maté; Vermeulen, Joëlle; De Paepe, Anne; Wong, Linda; Speleman, Franki; Chen, Caifu; Vandesompele, Jo

    2011-01-01

    While a growing body of evidence implicates regulatory miRNA modules in various aspects of human disease and development, insights into specific miRNA function remain limited. Here, we present an innovative approach to elucidate tissue-specific miRNA functions that goes beyond miRNA target prediction and expression correlation. This approach is based on a multi-level integration of corresponding miRNA and mRNA gene expression levels, miRNA target prediction, transcription factor target predic...

  14. Four Layered Approach to Non-Functional Requirements Analysis

    CERN Document Server

    Rao, A Ananda

    2012-01-01

    Identification of non-functional requirements is important for successful development and deployment of the software product. The acceptance of the software product by the customer depends on the non-functional requirements which are incorporated in the software. For this, we need to identify all the non-functional requirements required by all stakeholders. In the literature not many approaches are available for this purpose. Hence, we have proposed a four layered analysis approach for identification of non-functional requirements. The proposed layered approach has many advantages over non-layered approach. As part of this approach some rules are also proposed to be used in each layer. The approach is applied successfully on two case studies. The identified non-functional requirements are validated using a check list and in addition the completeness of the identified non-requirements is computed using a metric.

  15. Translation: Towards a Critical-Functional Approach

    Science.gov (United States)

    Sadeghi, Sima; Ketabi, Saeed

    2010-01-01

    The controversy over the place of translation in the teaching of English as a Foreign Language (EFL) is a thriving field of inquiry. Many older language teaching methodologies such as the Direct Method, the Audio-lingual Method, and Natural and Communicative Approaches, tended to either neglect the role of translation, or prohibit it entirely as a…

  16. Science based integrated approach to advanced nuclear fuel development - vision, approach, and overview

    Energy Technology Data Exchange (ETDEWEB)

    Unal, Cetin [Los Alamos National Laboratory; Pasamehmetoglu, Kemal [IDAHO NATIONAL LAB; Carmack, Jon [IDAHO NATIONAL LAB

    2010-01-01

    Advancing the performance of Light Water Reactors, Advanced Nuclear Fuel Cycles, and Advanced Rcactors, such as the Next Generation Nuclear Power Plants, requires enhancing our fundamental understanding of fuel and materials behavior under irradiation. The capability to accurately model the nuclear fuel systems is critical. In order to understand specific aspects of the nuclear fuel, fully coupled fuel simulation codes are required to achieve licensing of specific nuclear fuel designs for operation. The backbone of these codes, models, and simulations is a fundamental understanding and predictive capability for simulating the phase and microstructural behavior of the nuclear fuel system materials and matrices. The purpose of this paper is to identify the modeling and simulation approach in order to deliver predictive tools for advanced fuels development. The coordination between experimental nuclear fuel design, development technical experts, and computational fuel modeling and simulation technical experts is a critical aspect of the approach and naturally leads to an integrated, goal-oriented science-based R & D approach and strengthens both the experimental and computational efforts. The Advanced Fuels Campaign (AFC) and Nuclear Energy Advanced Modeling and Simulation (NEAMS) Fuels Integrated Performance and Safety Code (IPSC) are working together to determine experimental data and modeling needs. The primary objective of the NEAMS fuels IPSC project is to deliver a coupled, three-dimensional, predictive computational platform for modeling the fabrication and both normal and abnormal operation of nuclear fuel pins and assemblies, applicable to both existing and future reactor fuel designs. The science based program is pursuing the development of an integrated multi-scale and multi-physics modeling and simulation platform for nuclear fuels. This overview paper discusses the vision, goals and approaches how to develop and implement the new approach.

  17. Science based integrated approach to advanced nuclear fuel development - vision, approach, and overview

    Energy Technology Data Exchange (ETDEWEB)

    Unal, Cetin [Los Alamos National Laboratory; Pasamehmetoglu, Kemal [IDAHO NATIONAL LAB; Carmack, Jon [IDAHO NATIONAL LAB

    2010-01-01

    Advancing the performance of Light Water Reactors, Advanced Nuclear Fuel Cycles, and Advanced Rcactors, such as the Next Generation Nuclear Power Plants, requires enhancing our fundamental understanding of fuel and materials behavior under irradiation. The capability to accurately model the nuclear fuel systems is critical. In order to understand specific aspects of the nuclear fuel, fully coupled fuel simulation codes are required to achieve licensing of specific nuclear fuel designs for operation. The backbone of these codes, models, and simulations is a fundamental understanding and predictive capability for simulating the phase and microstructural behavior of the nuclear fuel system materials and matrices. The purpose of this paper is to identify the modeling and simulation approach in order to deliver predictive tools for advanced fuels development. The coordination between experimental nuclear fuel design, development technical experts, and computational fuel modeling and simulation technical experts is a critical aspect of the approach and naturally leads to an integrated, goal-oriented science-based R & D approach and strengthens both the experimental and computational efforts. The Advanced Fuels Campaign (AFC) and Nuclear Energy Advanced Modeling and Simulation (NEAMS) Fuels Integrated Performance and Safety Code (IPSC) are working together to determine experimental data and modeling needs. The primary objective of the NEAMS fuels IPSC project is to deliver a coupled, three-dimensional, predictive computational platform for modeling the fabrication and both normal and abnormal operation of nuclear fuel pins and assemblies, applicable to both existing and future reactor fuel designs. The science based program is pursuing the development of an integrated multi-scale and multi-physics modeling and simulation platform for nuclear fuels. This overview paper discusses the vision, goals and approaches how to develop and implement the new approach.

  18. Systems approaches to integrated solid waste management in developing countries

    Energy Technology Data Exchange (ETDEWEB)

    Marshall, Rachael E., E-mail: rmarsh01@uoguelph.ca [School of Engineering, University of Guelph, Albert A. Thornbrough Building, Guelph, ON, Canada N1G 2W1 (Canada); Farahbakhsh, Khosrow, E-mail: khosrowf@uoguelph.ca [School of Engineering, University of Guelph, Albert A. Thornbrough Building, Guelph, ON, Canada N1G 2W1 (Canada)

    2013-04-15

    Highlights: ► Five drivers led developed countries to current solid waste management paradigm. ► Many unique factors challenge developing country solid waste management. ► Limited transferability of developed country approaches to developing countries. ► High uncertainties and decision stakes call for post-normal approaches. ► Systems thinking needed for multi-scale, self-organizing eco-social waste systems. - Abstract: Solid waste management (SWM) has become an issue of increasing global concern as urban populations continue to rise and consumption patterns change. The health and environmental implications associated with SWM are mounting in urgency, particularly in the context of developing countries. While systems analyses largely targeting well-defined, engineered systems have been used to help SWM agencies in industrialized countries since the 1960s, collection and removal dominate the SWM sector in developing countries. This review contrasts the history and current paradigms of SWM practices and policies in industrialized countries with the current challenges and complexities faced in developing country SWM. In industrialized countries, public health, environment, resource scarcity, climate change, and public awareness and participation have acted as SWM drivers towards the current paradigm of integrated SWM. However, urbanization, inequality, and economic growth; cultural and socio-economic aspects; policy, governance, and institutional issues; and international influences have complicated SWM in developing countries. This has limited the applicability of approaches that were successful along the SWM development trajectories of industrialized countries. This review demonstrates the importance of founding new SWM approaches for developing country contexts in post-normal science and complex, adaptive systems thinking.

  19. A reproducible approach to high-throughput biological data acquisition and integration

    Directory of Open Access Journals (Sweden)

    Daniela Börnigen

    2015-03-01

    Full Text Available Modern biological research requires rapid, complex, and reproducible integration of multiple experimental results generated both internally and externally (e.g., from public repositories. Although large systematic meta-analyses are among the most effective approaches both for clinical biomarker discovery and for computational inference of biomolecular mechanisms, identifying, acquiring, and integrating relevant experimental results from multiple sources for a given study can be time-consuming and error-prone. To enable efficient and reproducible integration of diverse experimental results, we developed a novel approach for standardized acquisition and analysis of high-throughput and heterogeneous biological data. This allowed, first, novel biomolecular network reconstruction in human prostate cancer, which correctly recovered and extended the NFκB signaling pathway. Next, we investigated host-microbiome interactions. In less than an hour of analysis time, the system retrieved data and integrated six germ-free murine intestinal gene expression datasets to identify the genes most influenced by the gut microbiota, which comprised a set of immune-response and carbohydrate metabolism processes. Finally, we constructed integrated functional interaction networks to compare connectivity of peptide secretion pathways in the model organisms Escherichia coli, Bacillus subtilis, and Pseudomonas aeruginosa.

  20. Modeling fabrication of nuclear components: An integrative approach

    Energy Technology Data Exchange (ETDEWEB)

    Hench, K.W.

    1996-08-01

    Reduction of the nuclear weapons stockpile and the general downsizing of the nuclear weapons complex has presented challenges for Los Alamos. One is to design an optimized fabrication facility to manufacture nuclear weapon primary components in an environment of intense regulation and shrinking budgets. This dissertation presents an integrative two-stage approach to modeling the casting operation for fabrication of nuclear weapon primary components. The first stage optimizes personnel radiation exposure for the casting operation layout by modeling the operation as a facility layout problem formulated as a quadratic assignment problem. The solution procedure uses an evolutionary heuristic technique. The best solutions to the layout problem are used as input to the second stage - a simulation model that assesses the impact of competing layouts on operational performance. The focus of the simulation model is to determine the layout that minimizes personnel radiation exposures and nuclear material movement, and maximizes the utilization of capacity for finished units.

  1. Infectious diseases in oyster aquaculture require a new integrated approach

    Science.gov (United States)

    Lupo, Coralie; Whittington, Richard J.

    2016-01-01

    Emerging diseases pose a recurrent threat to bivalve aquaculture. Recently, massive mortality events in the Pacific oyster Crassostrea gigas associated with the detection of a microvariant of the ostreid herpesvirus 1 (OsHV-1µVar) have been reported in Europe, Australia and New Zealand. Although the spread of disease is often viewed as a governance failure, we suggest that the development of protective measures for bivalve farming is presently held back by the lack of key scientific knowledge. In this paper, we explore the case for an integrated approach to study the management of bivalve disease, using OsHV-1 as a case study. Reconsidering the key issues by incorporating multidisciplinary science could provide a holistic understanding of OsHV-1 and increase the benefit of research to policymakers. PMID:26880845

  2. First- and Third-person Approaches: the Problem of Integration

    Directory of Open Access Journals (Sweden)

    Olga Markič

    2012-10-01

    Full Text Available The author discusses the problem of integration of first- and third-person approaches in studying the human mind. She critically evaluates and compares various methodologies for studying and explaining conscious experience. Common strategies that apply reductive explanation seem to be unsatisfied for explaining experience and its subjective character. There were attempts to explain experience from the first-person point of view (introspectionism, philosophical phenomenology but the results were not intersubjectively verifiable. Dennett proposed heterophenomenology as a scientifically viable alternative which supposed to bridge the gap between first- and third-person perspectives. The author critically evaluates his proposal and compares it to contemporary attempts to provide first-person methods.

  3. An integrated MCDM approach to green supplier selection

    Directory of Open Access Journals (Sweden)

    Morteza Yazdani

    2014-06-01

    Full Text Available Supplier selection management has been considered as an important subject for industrial organizations. In order to remain on the market, to gain profitability and to retain competitive advantage, business units need to establish an integrated and structured supplier selection system. In addition, environmental protection problems have been big solicitudes for organizations to consider green approach in supplier selection problem. However, finding proper suppliers involves several variables and it is critically a complex process. In this paper, the main attention is focused on finding the right supplier based on fuzzy multi criteria decision making (MCDM process. The weights of criteria are calculated by analytical hierarchical process (AHP and the final ranking is achieved by fuzzy technique for order preference by similarity to an ideal solution (TOPSIS. TOPSIS advantage among the other similar methods is to obtain the best solution close to ideal solution. The paper attempts to express better understanding by an example of an automobile manufacturing supply chain.

  4. Engineering systems reliability, safety, and maintenance an integrated approach

    CERN Document Server

    Dhillon, B S

    2017-01-01

    Today, engineering systems are an important element of the world economy and each year billions of dollars are spent to develop, manufacture, operate, and maintain various types of engineering systems around the globe. Many of these systems are highly sophisticated and contain millions of parts. For example, a Boeing jumbo 747 is made up of approximately 4.5 million parts including fasteners. Needless to say, reliability, safety, and maintenance of systems such as this have become more important than ever before.  Global competition and other factors are forcing manufacturers to produce highly reliable, safe, and maintainable engineering products. Therefore, there is a definite need for the reliability, safety, and maintenance professionals to work closely during design and other phases. Engineering Systems Reliability, Safety, and Maintenance: An Integrated Approach eliminates the need to consult many different and diverse sources in the hunt for the information required to design better engineering syste...

  5. Towards an integrated approach in supporting microbiological food safety decisions

    DEFF Research Database (Denmark)

    Havelaar, A.H.; Braunig, J.; Christiansen, K.

    2007-01-01

    Decisions on food safety involve consideration of a wide range of concerns including the public health impact of foodborne illness, the economic importance of the agricultural sector and the food industry, and the effectiveness and efficiency of interventions. To support such decisions, we propose...... an integrated scientific approach combining veterinary and medical epidemiology, risk assessment for the farm-to-fork food chain as well as agricultural and health economy. Scientific advice is relevant in all stages of the policy cycle: to assess the magnitude of the food safety problem, to define...... the priorities for action, to establish the causes for the problem, to choose between different control options, to define targets along the food chain and to measure success....

  6. A New Approach to Integrable Theories in any Dimension

    CERN Document Server

    Alvarez, O; Sánchez-Guillén, J; Alvarez, Orlando; Ferreira, Luiz A.

    1998-01-01

    The zero curvature representation for two dimensional integrable models is generalized to spacetimes of dimension $d+1$ by the introduction of a $d$-form connection. The new generalized zero curvature conditions can be used to represent the equations of motion of some relativistic invariant field theories of physical interest in 2+1 dimensions (BF theories, Chern-Simons, 2+1 gravity and the $CP^1$ model) and 3+1 dimensions (self-dual Yang-Mills theory and the Bogomolny equations). Our approach leads to new methods of constructing conserved currents and solutions. In a submodel of the 2+1 dimensional $CP^1$ model, we explicitly construct an infinite number of previously unknown nontrivial conserved currents. For each positive integer spin representation of $sl(2)$ we construct $2j+1$ conserved currents.

  7. New Approach to Fractal Approximation of Vector-Functions

    Directory of Open Access Journals (Sweden)

    Konstantin Igudesman

    2015-01-01

    Full Text Available This paper introduces new approach to approximation of continuous vector-functions and vector sequences by fractal interpolation vector-functions which are multidimensional generalization of fractal interpolation functions. Best values of fractal interpolation vector-functions parameters are found. We give schemes of approximation of some sets of data and consider examples of approximation of smooth curves with different conditions.

  8. A novel virtual hub approach for multisource downstream service integration

    Science.gov (United States)

    Previtali, Mattia; Cuca, Branka; Barazzetti, Luigi

    2016-08-01

    A large development of downstream services is expected to be stimulated starting from earth observations (EO) datasets acquired by Copernicus satellites. An important challenge connected with the availability of downstream services is the possibility for their integration in order to create innovative applications with added values for users of different categories level. At the moment, the world of geo-information (GI) is extremely heterogeneous in terms of standards and formats used, thus preventing a facilitated access and integration of downstream services. Indeed, different users and data providers have also different requirements in terms of communication protocols and technology advancement. In recent years, many important programs and initiatives have tried to address this issue even on trans-regional and international level (e.g. INSPIRE Directive, GEOSS, Eye on Earth and SEIS). However, a lack of interoperability between systems and services still exists. In order to facilitate the interaction between different downstream services, a new architectural approach (developed within the European project ENERGIC OD) is proposed in this paper. The brokering-oriented architecture introduces a new mediation layer (the Virtual Hub) which works as an intermediary to bridge the gaps linked to interoperability issues. This intermediation layer de-couples the server and the client allowing a facilitated access to multiple downstream services and also Open Data provided by national and local SDIs. In particular, in this paper an application is presented integrating four services on the topic of agriculture: (i) the service given by Space4Agri (providing services based on MODIS and Landsat data); (ii) Gicarus Lab (providing sample services based on Landsat datasets) and (iii) FRESHMON (providing sample services for water quality) and services from a several regional SDIs.

  9. Intermodal Transport Security: Need for an Integrated Approach

    Directory of Open Access Journals (Sweden)

    Nil Kula Degirmenci

    2012-11-01

    Full Text Available Transportation industry has been facing challenges due to various security-related issues such as piracy, terrorism, thefts and accidents. Intermodal transportation as a system that incorporates many players, transportation modes, interchange points as well as various technologies can also be considered as an important platform for securityrelated problems. Although intermodal transportation is quite vulnerable to security-related risks, recent literature heavily focused on the security problems of specific transportation modes. Since intermodal industry consists of many operations, vehicles and actors, responding to security-related issues for each transportation mode only may not be sufficient. In the light of these, this study mainly aims to provide a framework for overall understanding of the security concept in the intermodal transportation chain. The study firstly focuses on the security dimension of each transportation mode that can be a part of an intermodal transportation chain by considering mainly legal, technological and economic factors. Then, a framework is suggested which identifies the main components of security in intermodal transport by focusing on the need for an integrated approach. Since the evaluation of security dimension in transportation industry is only limited to the industry projects and analysis of specific transport modes; mainly sea transport, it is believed that this study will provide significant contribution to the understanding and the evaluation of security concept in intermodal transportation system. This will be achieved through the identification of main security gaps in the system and the analysis of the intermodal transportation security concept. Moreover, some suggestions will be provided in the light of the factors mentioned in order to provide an overall intermodal security framework and an integrated approach.

  10. The quench action approach in finite integrable spin chains

    Science.gov (United States)

    Alba, Vincenzo; Calabrese, Pasquale

    2016-04-01

    We consider the problem of constructing the stationary state following a quantum quench, using the exact overlaps for finite size integrable models. We focus on the isotropic Heisenberg spin chain with initial state Néel or Majumdar-Ghosh (dimer), although the proposed approach is valid for an arbitrary integrable model. We consider only eigenstates which do not contain zero-momentum strings because the latter are affected by fictitious singularities that are very difficult to take into account. We show that the fraction of eigenstates that do not contain zero-momentum strings is vanishing in the thermodynamic limit. Consequently, restricting to this part of the Hilbert space leads to vanishing expectation values of local observables. However, it is possible to reconstruct the asymptotic values by properly reweighting the expectations in the considered subspace, at the price of introducing finite-size corrections. We also develop a Monte Carlo sampling of the Hilbert space which allows us to study larger systems. We accurately reconstruct the expectation values of the conserved charges and the root distributions in the stationary state, which turn out to match the exact thermodynamic results. The proposed method can be implemented even in cases in which an analytic thermodynamic solution is not obtainable.

  11. An integrated approach of composting methodologies for solid waste management

    Directory of Open Access Journals (Sweden)

    K. Kumaresan

    2016-03-01

    Full Text Available Organic fraction of solid waste, which upon degradation produces foul smell and generates pathogens, if not properly managed. Composting is not a method of waste disposal but it is a method of waste recycling and used for agricultural purposes. An integrated approach of composting methodology was tested for municipal solid waste management. Solid waste first was composted and after 22 days, was further processed by vermicomposting. Samples were routinely taken for analysis of carbon, nitrogen, moisture content, pH and temperature to determine the quality of composting. Decrease in moisture content to 32.1 %, relative decrease in carbon and nitrogen content were also observed. Among the different types of treatment, municipal solid waste + activated sludge integration showed promising results, followed by vermicomposting municipal solid waste + activated sludge combination, compared to the combinations of dried activated sludge, municipal solid waste + activated sludge semisolid and municipal solid waste + sewage water. Thus, windrow composting followed by vermicomposting gave a better result than other methods. Thus this method would serve as a potential alternative for solid waste management.

  12. Function-based integration strategy for an agile manufacturing testbed

    Science.gov (United States)

    Park, Hisup

    1997-01-01

    This paper describes an integration strategy for plug-and- play software based on functional descriptions of the software modules. The functional descriptions identify explicitly the role of each module with respect to the overall systems. They define the critical dependencies that affect the individual modules and thus affect the behavior of the system. The specified roles, dependencies and behavioral constraints are then incorporated in a group of shared objects that are distributed over a network. These objects may be interchanged with others without disrupting the system so long as the replacements meet the interface and functional requirements. In this paper, we propose a framework for modeling the behavior of plug-and-play software modules that will be used to (1) design and predict the outcome of the integration, (2) generate the interface and functional requirements of individual modules, and (3) form a dynamic foundation for applying interchangeable software modules. I describe this strategy in the context of the development of an agile manufacturing testbed. The testbed represents a collection of production cells for machining operations, supported by a network of software modules or agents for planning, fabrication, and inspection. A process definition layer holds the functional description of the software modules. A network of distributed objects interact with one another over the Internet and comprise the plug-compatible software nodes that execute these functions. This paper will explore the technical and operational ramifications of using the functional description framework to organize and coordinate the distributed object modules.

  13. Towards an Integrated Approach to Perception and Action: Conference Report and Future Directions

    Directory of Open Access Journals (Sweden)

    Goren eGordon

    2011-04-01

    Full Text Available This article was motivated by the conference entitled ‘Perception & Action – An Interdisciplinary Approach to Cognitive Systems Theory’, which took place September 14-16, 2010 at the Santa Fe Institute, NM, U.S.A. The goal of the conference was to bring together an interdisciplinary group of neuroscientists, roboticists and theorists to discuss the extent and implications of action-perception integration in the brain. The motivation for the conference was the realization that it is a widespread approach in biological, theoretical and computational neuroscience to investigate sensory and motor function of the brain in isolation from one another, while at the same time, it is generally appreciated that sensory and motor processing cannot be fully separated. Our article summarizes the key findings of the conference, provides a hypothetical model that integrates the major themes and concepts presented at the conference, and concludes with a perspective on future challenges in the field.

  14. Predictive functional control of integrating process based on impulse response

    Institute of Scientific and Technical Information of China (English)

    Bin ZHANG; Ping LI; Weidong ZHANG

    2004-01-01

    The predictive model is built according to the characteristics of the impulse response of integrating process. In order to eliminate the permanent offset between the setpoint and the process output in the presence of the load disturbance, a novel error compensation method is proposed. Then predictive functional control of integrating process is designed. The method given generates a simple control structure, which can significantly reduce online computation. Furthermore, the tuning of the controller is fairly straightforward. Simulation results indicate that the designed control system is relatively robust to the parameters variation of the process.

  15. Functional renormalization group approach to neutron matter

    Directory of Open Access Journals (Sweden)

    Matthias Drews

    2014-11-01

    Full Text Available The chiral nucleon-meson model, previously applied to systems with equal number of neutrons and protons, is extended to asymmetric nuclear matter. Fluctuations are included in the framework of the functional renormalization group. The equation of state for pure neutron matter is studied and compared to recent advanced many-body calculations. The chiral condensate in neutron matter is computed as a function of baryon density. It is found that, once fluctuations are incorporated, the chiral restoration transition for pure neutron matter is shifted to high densities, much beyond three times the density of normal nuclear matter.

  16. A Planning Approach of Engineering Characteristics Based on QFD-TRIZ Integrated

    Science.gov (United States)

    Liu, Shang; Shi, Dongyan; Zhang, Ying

    Traditional QFD planning method compromises contradictions between engineering characteristics to achieve higher customer satisfaction. However, this compromise trade-off can not eliminate the contradictions existing among the engineering characteristics which limited the overall customer satisfaction. QFD (Quality function deployment) integrated with TRIZ (the Russian acronym of the Theory of Inventive Problem Solving) becomes hot research recently for TRIZ can be used to solve contradictions between engineering characteristics which construct the roof of HOQ (House of quality). But, the traditional QFD planning approach is not suitable for QFD integrated with TRIZ for that TRIZ requires emphasizing the contradictions between engineering characteristics at problem definition stage instead of compromising trade-off. So, a new planning approach based on QFD / TRIZ integration is proposed in this paper, which based on the consideration of the correlation matrix of engineering characteristics and customer satisfaction on the basis of cost. The proposed approach suggests that TRIZ should be applied to solve contradictions at the first step, and the correlation matrix of engineering characteristics should be amended at the second step, and at next step IFR (ideal final result) must be validated, then planning execute. An example is used to illustrate the proposed approach. The application indicated that higher customer satisfaction can be met and the contradictions between the characteristic parameters are eliminated.

  17. Project INTEGRATE - a common methodological approach to understand integrated health care in Europe

    Directory of Open Access Journals (Sweden)

    Lucinda Cash-Gibson

    2014-12-01

    Full Text Available Background: The use of case studies in health services research has proven to be an excellent methodology for gaining in-depth understanding of the organisation and delivery of health care. This is particularly relevant when looking at the complexity of integrated healthcare programmes, where multifaceted interactions occur at the different levels of care and often without a clear link between the interventions (new and/or existing and their impact on outcomes (in terms of patients health, both patient and professional satisfaction and cost-effectiveness. Still, integrated care is seen as a core strategy in the sustainability of health and care provision in most societies in Europe and beyond. More specifically, at present, there is neither clear evidence on transferable factors of integrated care success nor a method for determining how to establish these specific success factors. The drawback of case methodology in this case, however, is that the in-depth results or lessons generated are usually highly context-specific and thus brings the challenge of transferability of findings to other settings, as different health care systems and different indications are often not comparable. Project INTEGRATE, a European Commission-funded project, has been designed to overcome these problems; it looks into four chronic conditions in different European settings, under a common methodology framework (taking a mixed-methods approach to try to overcome the issue of context specificity and limited transferability. The common methodological framework described in this paper seeks to bring together the different case study findings in a way that key lessons may be derived and transferred between countries, contexts and patient-groups, where integrated care is delivered in order to provide insight into generalisability and build on existing evidence in this field.Methodology: To compare the different integrated care experiences, a mixed-methods approach has

  18. Project INTEGRATE - a common methodological approach to understand integrated health care in Europe

    Directory of Open Access Journals (Sweden)

    Lucinda Cash-Gibson

    2014-12-01

    Full Text Available Background: The use of case studies in health services research has proven to be an excellent methodology for gaining in-depth understanding of the organisation and delivery of health care. This is particularly relevant when looking at the complexity of integrated healthcare programmes, where multifaceted interactions occur at the different levels of care and often without a clear link between the interventions (new and/or existing and their impact on outcomes (in terms of patients health, both patient and professional satisfaction and cost-effectiveness. Still, integrated care is seen as a core strategy in the sustainability of health and care provision in most societies in Europe and beyond. More specifically, at present, there is neither clear evidence on transferable factors of integrated care success nor a method for determining how to establish these specific success factors. The drawback of case methodology in this case, however, is that the in-depth results or lessons generated are usually highly context-specific and thus brings the challenge of transferability of findings to other settings, as different health care systems and different indications are often not comparable. Project INTEGRATE, a European Commission-funded project, has been designed to overcome these problems; it looks into four chronic conditions in different European settings, under a common methodology framework (taking a mixed-methods approach to try to overcome the issue of context specificity and limited transferability. The common methodological framework described in this paper seeks to bring together the different case study findings in a way that key lessons may be derived and transferred between countries, contexts and patient-groups, where integrated care is delivered in order to provide insight into generalisability and build on existing evidence in this field. Methodology: To compare the different integrated care experiences, a mixed-methods approach has

  19. Theory of Atom Optics: Feynman's Path Integral Approach

    Institute of Scientific and Technical Information of China (English)

    DENG Lü-bi

    2006-01-01

    The present theory of atom optics is established mainly on the Schr(o)dinger equations or the matrix mechanics equation.The authors present a new theoretical formulation of atom optics: Feynman's path integral theory.Its advantage is that one can describe the diffraction and interference of atoms passing through slits (or grating),apertures,and standing wave laser field in Earth's gravitational field by using a type of wave function and calculation is simple.For this reason,we derive the wave functions of particles in the following configurations: single slit (and slit with the van der Waals interaction),double slit,N slit,rectangular aperture,circular aperture,the Mach-Zehndertype interferometer,the interferometer with the Raman beams,the Sagnac effect,the Aharonov-Casher effect,the Kapitza-Dirac diffraction effect,and the Aharonov-Bohm effect.The authors give a wave function of the state of particles on the screen in abovementioned configurations.Our formulas show good agreement with present experimental measurements.

  20. Systems approaches to integrated solid waste management in developing countries.

    Science.gov (United States)

    Marshall, Rachael E; Farahbakhsh, Khosrow

    2013-04-01

    Solid waste management (SWM) has become an issue of increasing global concern as urban populations continue to rise and consumption patterns change. The health and environmental implications associated with SWM are mounting in urgency, particularly in the context of developing countries. While systems analyses largely targeting well-defined, engineered systems have been used to help SWM agencies in industrialized countries since the 1960s, collection and removal dominate the SWM sector in developing countries. This review contrasts the history and current paradigms of SWM practices and policies in industrialized countries with the current challenges and complexities faced in developing country SWM. In industrialized countries, public health, environment, resource scarcity, climate change, and public awareness and participation have acted as SWM drivers towards the current paradigm of integrated SWM. However, urbanization, inequality, and economic growth; cultural and socio-economic aspects; policy, governance, and institutional issues; and international influences have complicated SWM in developing countries. This has limited the applicability of approaches that were successful along the SWM development trajectories of industrialized countries. This review demonstrates the importance of founding new SWM approaches for developing country contexts in post-normal science and complex, adaptive systems thinking.

  1. Phytoremediation of coal mine spoil dump through integrated biotechnological approach

    Energy Technology Data Exchange (ETDEWEB)

    Juwarkar, A.A.; Jambhulkar, H.P. [National Environmental Engineering Research Institute, Nagpur (India)

    2008-07-15

    Field experiment was conducted on mine spoil dump on an area of 10 ha, to restore the fertility and productivity of the coal mine spoil dump using integrated biotechnological approach. The approach involves use of effluent treatment plant sludge (ETP sludge), as an organic amendment, biofertilizers and mycorrihzal fungi along with suitable plant species. The results of the study indicated that amendment with effluent treatment plant sludge (ETP sludge), at 50 ton/ha improved the physico-chemical properties of coal mine spoil. Due to biofertilizer inoculation different microbial groups such as Rhizobium, Azotobacter and VAM spores, which were practically absent in mine spoil improved greatly. Inoculation of biofertilizer and application of ETP sludge helped in reducing the toxicity of heavy metals such as chromium, zinc, copper, iron, manganese lead, nickel and cadmium, which were significantly reduced to 41%, 43%, 37%, 37%, 34%, 39%, 37% and 40%, respectively, due to the increased organic matter content in the ETP sludge and its alkaline pH (8.10-8.28), at which the metals gets immobilized and translocation of metals is arrested. Thus, amendment and biofertilizer application provided better supportive material for anchorage and growth of the plant on coal mine spoil dump.

  2. Distortion-Free Watermarking Approach for Relational Database Integrity Checking

    Directory of Open Access Journals (Sweden)

    Lancine Camara

    2014-01-01

    Full Text Available Nowadays, internet is becoming a suitable way of accessing the databases. Such data are exposed to various types of attack with the aim to confuse the ownership proofing or the content protection. In this paper, we propose a new approach based on fragile zero watermarking for the authentication of numeric relational data. Contrary to some previous databases watermarking techniques which cause some distortions in the original database and may not preserve the data usability constraints, our approach simply seeks to generate the watermark from the original database. First, the adopted method partitions the database relation into independent square matrix groups. Then, group-based watermarks are securely generated and registered in a trusted third party. The integrity verification is performed by computing the determinant and the diagonal’s minor for each group. As a result, tampering can be localized up to attribute group level. Theoretical and experimental results demonstrate that the proposed technique is resilient against tuples insertion, tuples deletion, and attributes values modification attacks. Furthermore, comparison with recent related effort shows that our scheme performs better in detecting multifaceted attacks.

  3. Social Network Analyses and Nutritional Behavior: An Integrated Modeling Approach

    Directory of Open Access Journals (Sweden)

    Alistair McNair Senior

    2016-01-01

    Full Text Available Animals have evolved complex foraging strategies to obtain a nutritionally balanced diet and associated fitness benefits. Recent advances in nutrition research, combining state-space models of nutritional geometry with agent-based models of systems biology, show how nutrient targeted foraging behavior can also influence animal social interactions, ultimately affecting collective dynamics and group structures. Here we demonstrate how social network analyses can be integrated into such a modeling framework and provide a tangible and practical analytical tool to compare experimental results with theory. We illustrate our approach by examining the case of nutritionally mediated dominance hierarchies. First we show how nutritionally explicit agent-based models that simulate the emergence of dominance hierarchies can be used to generate social networks. Importantly the structural properties of our simulated networks bear similarities to dominance networks of real animals (where conflicts are not always directly related to nutrition. Finally, we demonstrate how metrics from social network analyses can be used to predict the fitness of agents in these simulated competitive environments. Our results highlight the potential importance of nutritional mechanisms in shaping dominance interactions in a wide range of social and ecological contexts. Nutrition likely influences social interaction in many species, and yet a theoretical framework for exploring these effects is currently lacking. Combining social network analyses with computational models from nutritional ecology may bridge this divide, representing a pragmatic approach for generating theoretical predictions for nutritional experiments.

  4. Social Network Analysis and Nutritional Behavior: An Integrated Modeling Approach.

    Science.gov (United States)

    Senior, Alistair M; Lihoreau, Mathieu; Buhl, Jerome; Raubenheimer, David; Simpson, Stephen J

    2016-01-01

    Animals have evolved complex foraging strategies to obtain a nutritionally balanced diet and associated fitness benefits. Recent research combining state-space models of nutritional geometry with agent-based models (ABMs), show how nutrient targeted foraging behavior can also influence animal social interactions, ultimately affecting collective dynamics and group structures. Here we demonstrate how social network analyses can be integrated into such a modeling framework and provide a practical analytical tool to compare experimental results with theory. We illustrate our approach by examining the case of nutritionally mediated dominance hierarchies. First we show how nutritionally explicit ABMs that simulate the emergence of dominance hierarchies can be used to generate social networks. Importantly the structural properties of our simulated networks bear similarities to dominance networks of real animals (where conflicts are not always directly related to nutrition). Finally, we demonstrate how metrics from social network analyses can be used to predict the fitness of agents in these simulated competitive environments. Our results highlight the potential importance of nutritional mechanisms in shaping dominance interactions in a wide range of social and ecological contexts. Nutrition likely influences social interactions in many species, and yet a theoretical framework for exploring these effects is currently lacking. Combining social network analyses with computational models from nutritional ecology may bridge this divide, representing a pragmatic approach for generating theoretical predictions for nutritional experiments.

  5. Phytoremediation of coal mine spoil dump through integrated biotechnological approach.

    Science.gov (United States)

    Juwarkar, Asha A; Jambhulkar, Hemlata P

    2008-07-01

    Field experiment was conducted on mine spoil dump on an area of 10 ha, to restore the fertility and productivity of the coal mine spoil dump using integrated biotechnological approach. The approach involves use of effluent treatment plant sludge (ETP sludge), as an organic amendment, biofertilizers and mycorrihzal fungi along with suitable plant species. The results of the study indicated that amendment with effluent treatment plant sludge (ETP sludge), @ 50 ton/ha improved the physico-chemical properties of coal mine spoil. Due to biofertilizer inoculation different microbial groups such as Rhizobium, Azotobacter and VAM spores, which were practically absent in mine spoil improved greatly. Inoculation of biofertilizer and application of ETP sludge helped in reducing the toxicity of heavy metals such as chromium, zinc, copper, iron, manganese lead, nickel and cadmium, which were significantly reduced to 41%, 43%, 37%, 37%, 34%, 39%, 37% and 40%, respectively, due to the increased organic matter content in the ETP sludge and its alkaline pH (8.10-8.28), at which the metals gets immobilized and translocation of metals is arrested. Thus, amendment and biofertilizer application provided better supportive material for anchorage and growth of the plant on coal mine spoil dump.

  6. Integrated approach for coastal hazards and risks in Sri Lanka

    Science.gov (United States)

    Garcin, M.; Desprats, J. F.; Fontaine, M.; Pedreros, R.; Attanayake, N.; Fernando, S.; Siriwardana, C. H. E. R.; de Silva, U.; Poisson, B.

    2008-06-01

    The devastating impact of the tsunami of 26 December 2004 on the shores of the Indian Ocean recalled the importance of knowledge and the taking into account of coastal hazards. Sri Lanka was one of the countries most affected by this tsunami (e.g. 30 000 dead, 1 million people homeless and 70% of the fishing fleet destroyed). Following this tsunami, as part of the French post-tsunami aid, a project to establish a Geographical Information System (GIS) on coastal hazards and risks was funded. This project aims to define, at a pilot site, a methodology for multiple coastal hazards assessment that might be useful for the post-tsunami reconstruction and for development planning. This methodology could be applied to the whole coastline of Sri Lanka. The multi-hazard approach deals with very different coastal processes in terms of dynamics as well as in terms of return period. The first elements of this study are presented here. We used a set of tools integrating a GIS, numerical simulations and risk scenario modelling. While this action occurred in response to the crisis caused by the tsunami, it was decided to integrate other coastal hazards into the study. Although less dramatic than the tsunami these remain responsible for loss of life and damage. Furthermore, the establishment of such a system could not ignore the longer-term effects of climate change on coastal hazards in Sri Lanka. This GIS integrates the physical and demographic data available in Sri Lanka that is useful for assessing the coastal hazards and risks. In addition, these data have been used in numerical modelling of the waves generated during periods of monsoon as well as for the December 2004 tsunami. Risk scenarios have also been assessed for test areas and validated by field data acquired during the project. The results obtained from the models can be further integrated into the GIS and contribute to its enrichment and to help in better assessment and mitigation of these risks. The coastal

  7. Integrated approach for coastal hazards and risks in Sri Lanka

    Directory of Open Access Journals (Sweden)

    M. Garcin

    2008-06-01

    Full Text Available The devastating impact of the tsunami of 26 December 2004 on the shores of the Indian Ocean recalled the importance of knowledge and the taking into account of coastal hazards. Sri Lanka was one of the countries most affected by this tsunami (e.g. 30 000 dead, 1 million people homeless and 70% of the fishing fleet destroyed. Following this tsunami, as part of the French post-tsunami aid, a project to establish a Geographical Information System (GIS on coastal hazards and risks was funded. This project aims to define, at a pilot site, a methodology for multiple coastal hazards assessment that might be useful for the post-tsunami reconstruction and for development planning. This methodology could be applied to the whole coastline of Sri Lanka.

    The multi-hazard approach deals with very different coastal processes in terms of dynamics as well as in terms of return period. The first elements of this study are presented here. We used a set of tools integrating a GIS, numerical simulations and risk scenario modelling. While this action occurred in response to the crisis caused by the tsunami, it was decided to integrate other coastal hazards into the study. Although less dramatic than the tsunami these remain responsible for loss of life and damage. Furthermore, the establishment of such a system could not ignore the longer-term effects of climate change on coastal hazards in Sri Lanka.

    This GIS integrates the physical and demographic data available in Sri Lanka that is useful for assessing the coastal hazards and risks. In addition, these data have been used in numerical modelling of the waves generated during periods of monsoon as well as for the December 2004 tsunami. Risk scenarios have also been assessed for test areas and validated by field data acquired during the project. The results obtained from the models can be further integrated into the GIS and contribute to its enrichment and to help in better assessment and mitigation

  8. Occupational therapy using a sensory integrative approach for children with developmental disabilities.

    Science.gov (United States)

    Schaaf, Roseann C; Miller, Lucy Jane

    2005-01-01

    This article provides an introduction and overview of sensory integration theory as it is used in occupational therapy practice for children with developmental disabilities. This review of the theoretical tenets of the theory, its historical foundations, and early research provides the reader with a basis for exploring current uses and applications. The key principles of the sensory integrative approach, including concepts such as "the just right challenge" and "the adaptive response" as conceptualized by A. Jean Ayres, the theory's founder, are presented to familiarize the reader with the approach. The state of research in this area is presented, including studies underway to further delineate the subtypes of sensory integrative dysfunction, the neurobiological mechanisms of poor sensory processing, advances in theory development, and the development of a fidelity measure for use in intervention studies. Finally, this article reviews the current state of the evidence to support this approach and suggests that consensual knowledge and empirical research are needed to further elucidate the theory and its utility for a variety of children with developmental disabilities. This is especially critical given the public pressure by parents of children with autism and other developmental disabilities to obtain services and who have anecdotally noted the utility of sensory integration therapy for helping their children function more independently. Key limiting factors to research include lack of funding, paucity of doctorate trained clinicians and researchers in occupational therapy, and the inherent heterogeneity of the population of children affected by sensory integrative dysfunction. A call to action for occupational therapy researchers, funding agencies, and other professions is made to support ongoing efforts and to develop initiatives that will lead to better diagnoses and effective intervention for sensory integrative dysfunction, which will improve the lives of

  9. The evolution of water transport in plants: an integrated approach.

    Science.gov (United States)

    Pittermann, J

    2010-03-01

    This review examines the evolution of the plant vascular system from its beginnings in the green algae to modern arborescent plants, highlighting the recent advances in developmental, organismal, geochemical and climatological research that have contributed to our understanding of the evolution of xylem. Hydraulic trade-offs in vascular structure-function are discussed in the context of canopy support and drought and freeze-thaw stress resistance. This qualitative and quantitative neontological approach to palaeobotany may be useful for interpreting the water-transport efficiencies and hydraulic limits in fossil plants. Large variations in atmospheric carbon dioxide levels are recorded in leaf stomatal densities, and may have had profound impacts on the water conservation strategies of ancient plants. A hypothesis that links vascular function with stomatal density is presented and examined in the context of the evolution of wood and/or vessels. A discussion of the broader impacts of plant transport on hydrology and climate concludes this review.

  10. Many-electron integrals over gaussian basis functions. I. Recurrence relations for three-electron integrals

    CERN Document Server

    Barca, Giuseppe M J; Gill, Peter M W

    2016-01-01

    Explicitly-correlated F12 methods are becoming the first choice for high-accuracy molecular orbital calculations, and can often achieve chemical accuracy with relatively small gaussian basis sets. In most calculations, the many three- and four-electron integrals that formally appear in the theory are avoided through judicious use of resolutions of the identity (RI). However, in order not to jeopardize the intrinsic accuracy of the F12 wave function, the associated RI auxiliary basis set must be large. Here, inspired by the Head-Gordon-Pople (HGP) and PRISM algorithms for two-electron integrals, we present an algorithm to compute directly three-electron integrals over gaussian basis functions and a very general class of three-electron operators, without invoking RI approximations. A general methodology to derive vertical, transfer and horizontal recurrence relations is also presented.

  11. Integrated System Health Management: Foundational Concepts, Approach, and Implementation

    Science.gov (United States)

    Figueroa, Fernando

    2009-01-01

    A sound basis to guide the community in the conception and implementation of ISHM (Integrated System Health Management) capability in operational systems was provided. The concept of "ISHM Model of a System" and a related architecture defined as a unique Data, Information, and Knowledge (DIaK) architecture were described. The ISHM architecture is independent of the typical system architecture, which is based on grouping physical elements that are assembled to make up a subsystem, and subsystems combine to form systems, etc. It was emphasized that ISHM capability needs to be implemented first at a low functional capability level (FCL), or limited ability to detect anomalies, diagnose, determine consequences, etc. As algorithms and tools to augment or improve the FCL are identified, they should be incorporated into the system. This means that the architecture, DIaK management, and software, must be modular and standards-based, in order to enable systematic augmentation of FCL (no ad-hoc modifications). A set of technologies (and tools) needed to implement ISHM were described. One essential tool is a software environment to create the ISHM Model. The software environment encapsulates DIaK, and an infrastructure to focus DIaK on determining health (detect anomalies, determine causes, determine effects, and provide integrated awareness of the system to the operator). The environment includes gateways to communicate in accordance to standards, specially the IEEE 1451.1 Standard for Smart Sensors and Actuators.

  12. Integrating anatomy and function for zebrafish circuit analysis.

    Science.gov (United States)

    Arrenberg, Aristides B; Driever, Wolfgang

    2013-01-01

    Due to its transparency, virtually every brain structure of the larval zebrafish is accessible to light-based interrogation of circuit function. Advanced stimulation techniques allow the activation of optogenetic actuators at different resolution levels, and genetically encoded calcium indicators report the activity of a large proportion of neurons in the CNS. Large datasets result and need to be analyzed to identify cells that have specific properties-e.g., activity correlation to sensory stimulation or behavior. Advances in three-dimensional (3D) functional mapping in zebrafish are promising; however, the mere coordinates of implicated neurons are not sufficient. To comprehensively understand circuit function, these functional maps need to be placed into the proper context of morphological features and projection patterns, neurotransmitter phenotypes, and key anatomical landmarks. We discuss the prospect of merging functional and anatomical data in an integrated atlas from the perspective of our work on long-range dopaminergic neuromodulation and the oculomotor system. We propose that such a resource would help researchers to surpass current hurdles in circuit analysis to achieve an integrated understanding of anatomy and function.

  13. TRACTABILITY OF MULTIVARIATE INTEGRATION PROBLEM FOR PERIODIC CONTINUOUS FUNCTIONS

    Institute of Scientific and Technical Information of China (English)

    Fang Gensun; Long Jingfan

    2007-01-01

    The authors study the tractability and strong tractability of a multivariate integration problem in the worst case setting for weighted 1-periodic continuous functions spaces of d coordinates with absolutely convergent Fourier series. The authors reduce the initial error by a factor ε for functions from the unit ball of the weighted periodic continuous functions spaces. Tractability is the minimal number of function samples required to solve the problem in polynomial in ε-1 and d, and the strong tractability is the presence of only a polynomial dependence in ε-1. This problem has been recently studied for quasi-Monte Carlo quadrature rules, quadrature rules with non-negative coefficients,and rules for which all quadrature weights are arbitrary for weighted Korobov spaces of smooth periodic functions of d variables. The authors show that the tractability and strong tractability of a multivariate integration problem in worst case setting hold for the weighted periodic continuous functions spaces with absolutely convergent Fourier series under the same assumptions as in Ref. [14] on the weights of the Korobov space for quasi-Monte Carlo rules and rules for which all quadrature weights are non-negative. The arguments are not constructive.

  14. Highly functional tunnelling devices integrated in 3D

    DEFF Research Database (Denmark)

    Wernersson, Lars-Erik; Lind, Erik; Lindström, Peter;

    2003-01-01

    We present a new technology for integrating tunnelling devices in three dimensions. These devices are fabricated by the combination of the growth of semiconductor heterostructures with the controlled introduction of metallic elements into an epitaxial layer by an overgrowth technique. First, we use...... circuit in order to optimize the performance of the device. In addition to the tunnelling structure below the grating, these transistors may be integrated in 3D by the introduction of another tunnelling structure directly over the metal grating. In the integrated device structure, the gate acts...... to adjust the peak voltage of certain peaks in a controlled fashion, which creates a highly functional tunnelling device. These results show the need for a strong interaction between the development of circuit models and processing technology to develop new nano-electronic devices and circuits. Copyright...

  15. Accelerometer Method and Apparatus for Integral Display and Control Functions

    Science.gov (United States)

    Bozeman, Richard J., Jr. (Inventor)

    1998-01-01

    Method and apparatus for detecting mechanical vibrations and outputting a signal in response thereto is discussed. An accelerometer package having integral display and control functions is suitable for mounting upon the machinery to be monitored. Display circuitry provides signals to a bar graph display which may be used to monitor machine conditions over a period of time. Control switches may be set which correspond to elements in the bar graph to provide an alert if vibration signals increase in amplitude over a selected trip point. The circuitry is shock mounted within the accelerometer housing. The method provides for outputting a broadband analog accelerometer signal, integrating this signal to produce a velocity signal, integrating and calibrating the velocity signal before application to a display driver, and selecting a trip point at which a digitally compatible output signal is generated.

  16. On holographic three point functions for GKP strings from integrability

    CERN Document Server

    Kazama, Yoichi

    2011-01-01

    Adapting the powerful integrability-based formalism invented previously for the calculation of gluon scattering amplitudes at strong coupling, we develop a method for computing the holographic three point functions for the large spin limit of Gubser-Klebanov- Polyakov (GKP) strings. Although many of the ideas from the gluon scattering problem can be transplanted with minor modifications, the fact that the information of the external states is now encoded in the singularities at the vertex insertion points necessitates several new techniques. Notably, we develop a new generalized Riemann bilinear identity, which allows one to express the area integral in terms of appropriate contour integrals in the presence of such singularities. We also give some general discussions on how semiclassical vertex operators for heavy string states should be constructed systematically from the solutions of the Hamilton-Jacobi equation.

  17. Analytical Approaches to Verify Food Integrity: Needs and Challenges.

    Science.gov (United States)

    Stadler, Richard H; Tran, Lien-Anh; Cavin, Christophe; Zbinden, Pascal; Konings, Erik J M

    2016-09-01

    A brief overview of the main analytical approaches and practices to determine food authenticity is presented, addressing, as well, food supply chain and future requirements to more effectively mitigate food fraud. Food companies are introducing procedures and mechanisms that allow them to identify vulnerabilities in their food supply chain under the umbrella of a food fraud prevention management system. A key step and first line of defense is thorough supply chain mapping and full transparency, assessing the likelihood of fraudsters to penetrate the chain at any point. More vulnerable chains, such as those where ingredients and/or raw materials are purchased through traders or auctions, may require a higher degree of sampling, testing, and surveillance. Access to analytical tools is therefore pivotal, requiring continuous development and possibly sophistication in identifying chemical markers, data acquisition, and modeling. Significant progress in portable technologies is evident already today, for instance, as in the rapid testing now available at the agricultural level. In the near future, consumers may also have the ability to scan products in stores or at home to authenticate labels and food content. For food manufacturers, targeted analytical methods complemented by untargeted approaches are end control measures at the factory gate when the material is delivered. In essence, testing for food adulterants is an integral part of routine QC, ideally tailored to the risks in the individual markets and/or geographies or supply chains. The development of analytical methods is a first step in verifying the compliance and authenticity of food materials. A next, more challenging step is the successful establishment of global consensus reference methods as exemplified by the AOAC Stakeholder Panel on Infant Formula and Adult Nutritionals initiative, which can serve as an approach that could also be applied to methods for contaminants and adulterants in food. The food

  18. A composite-appropriate integration method of thick functional components in fibre-reinforced plastics

    Science.gov (United States)

    Filippatos, A.; Höhne, R.; Kliem, M.; Gude, M.

    2016-03-01

    The use of integrated structural health monitoring systems for critical composite parts, such as wind turbine blades, fuselage and wing parts, is an promising approach to guarantee a safe and efficient operational lifetime of such components. Therefore, the integration of thick functional components like sensors, actuators and electronic components is often necessary. An optimal integration of such components should be ensured without material imperfections in the composite structure, i.e. voids and resin rich areas, and failure of the functional components. In this paper, first investigations were undertaken for a basic understanding of the mechanical performance of a fibre reinforced plastic component with integrated functional elements. The influence of different materials and treatment methods for the encapsulation of electronic components was experimentally investigated under static and dynamic loading tests. By means of a parametric finite element model, the effects of an encapsulation and various parameters such as the shape and orientation of the electronic components were examined. Several encapsulation variants were investigated in order to minimise the chance of failure initiations. Based both on experimental and numerical results, a preferred composite integration concept was selected for an electronic board and some first recommendations for an optimal integration were derived.

  19. Analysis of DIS structure functions of the nucleon within truncated Mellin moments approach

    CERN Document Server

    Kotlorz, D

    2016-01-01

    We present generalized evolution equations and factorization in terms of the truncated Mellin moments (TMM) of the parton distributions and structure functions. We illustrate the $x$ and $Q^2$ dependence of TMM in the polarized case. Using the TMM approach we compare the integrals of $g_1$ with HERMES and COMPASS data from the limited $x$-ranges.

  20. Regularity for Minimizers to Anisotropic Integrals Functions with Nonstandard Growth

    Directory of Open Access Journals (Sweden)

    Miaomiao JIA

    2016-05-01

    Full Text Available In this paper we deal with the problem $$ u\\in C_{\\psi}(\\Omega, $$ $$ \\forall \\ \\omega\\in C_{\\psi}(\\Omega, \\ \\ \\int_\\Omega f(x,Dudx\\leq \\int_\\Omega f(x,D\\omegadx, $$ where $C_{\\psi}(\\Omega=\\{w\\in u_*+W_0^{1,(p_i}(\\Omega\\ such \\ that \\ x\\rightarrow f(x,Dw\\in L^1(\\Omega, \\ w\\geq\\psi, \\ a.e. \\ \\Omega\\}.$ We consider a minimizer $u:\\ \\Omega\\subset R^n\\rightarrow R$ among all functions that agree on the boundary $\\partial\\Omega$ with some fixed boundary value $u_*$. And we assume that the function $\\theta=max\\{u_*,\\psi\\}$ makes the density $f(x,Du$ more integrable under the obstacle problem and we prove that the minimizer $u$ enjoy higher integrability.

  1. The Development of Meta-functional Approaches in Translation Studies

    Institute of Scientific and Technical Information of China (English)

    李菁菁

    2012-01-01

      Functional linguistics has exerted an increasing impact on modern linguistic studies. Functional approaches, especial⁃ly metafunctions have undergone a process of development and improvement. The affirmation of the metafunctions of lan⁃guage has aroused more and more scholars’concern on the“functional”facet of language, especially in Translation studies. The formation and improvement of functional approaches are introduced separately.

  2. MicrobesOnline: an integrated portal for comparative functional genomics

    OpenAIRE

    Joachimiak, Marcin P.

    2014-01-01

    The Virtual Institute for Microbial Stress and Survival (VIMSS, http://vimss.lbl.gov/) funded by the Dept. of Energy's Genomics:GTL Program, is dedicated to using integrated environmental, functional genomic, and comparative sequence and phylogeny data to understand mechanisms by which microbes and microbial communities survive in uncertain environments while carrying out processes of interest for bioremediation and energy generation. To support this work, VIMSS has developed a Web portal, al...

  3. Design, Fabrication, Characterization and Modeling of Integrated Functional Materials

    Science.gov (United States)

    2012-10-01

    purpose of this project is to develop the novel science base both in the areas of multi-scale dimensional integration as well as multiple functional...iron oxide nanoparticles have been widely explored because of their potential applications in various fields, including storage media, environmental... Wold , J. Solid State Chem. 1972, 5, 136. 44. A. A. Gippius, K.S. Okhotnikov, M. Baeritz, A. V. Shevelkov, Solid State Phenomena 2009, 152, 287. 45. C

  4. Urysohn measure driven integral equations in the space of bounded variation functions and applications

    Science.gov (United States)

    Dimitriu, G.; Satco, B.

    2016-10-01

    Motivated by the fact that bounded variation (often discontinuous) functions frequently appear when studying integral equations that describe physical phenomena, we focus on the existence of bounded variation solutions for Urysohn integral measure driven equations. Due to numerous applications of Urysohn integral equations in various domains, problems of this kind have been extensively studied in literature, under more restrictive assumptions. Our approach concerns the framework of Kurzweil-Stieltjes integration, which allows the occurrence of high oscillatory features on the right hand side of the equation. A discussion about interesting consequences of our main result (given by particular cases of the measure driving the equation) is presented. Finally, we show the generality of our results by investigating two examples of impulsive type problems (from both theoretical and numerical perspective) and giving an application in electronics industry concerning polarization properties of ferroelectric materials.

  5. The relation of structural integrity and task-related functional connectivity in the aging brain.

    Science.gov (United States)

    Burianová, Hana; Marstaller, Lars; Choupan, Jeiran; Sepehrband, Farshid; Ziaei, Maryam; Reutens, David

    2015-10-01

    The relations among structural integrity, functional connectivity (FC), and cognitive performance in the aging brain are still understudied. Here, we used multimodal and multivariate approaches to specifically examine age-related changes in task-related FC, gray-matter volumetrics, white-matter integrity, and performance. Our results are two-fold, showing (i) age-related differences in FC of the working memory network and (ii) age-related recruitment of a compensatory network associated with better accuracy on the task. Increased connectivity in the compensatory network correlates positively with preserved white-matter integrity in bilateral frontoparietal tracks and with larger gray-matter volume of right inferior parietal lobule. These findings demonstrate the importance of structural integrity and FC in working memory performance associated with healthy aging.

  6. Toward an Integrative Approach to Assessment and Treatment Planning in Family Therapy.

    Science.gov (United States)

    Olsen, David C.

    The rapid increase in literature and modalities of family therapy has made it difficult for counselors working with families to find an integrative approach to assessment and treatment planning. As a result, many counselors move from one paradigm to another without attempting to integrate approaches. This paper attempts to integrate five paradigms…

  7. Spaceability and algebrability of sets of nowhere integrable functions

    OpenAIRE

    Glab, Szymon; Kaufmann, Pedro L.; Pellegrini, Leonardo

    2012-01-01

    We show that the set of Lebesgue integrable functions in $[0,1]$ which are nowhere essentially bounded is spaceable, improving a result from [F. J. Garc\\'{i}a-Pacheco, M. Mart\\'{i}n, and J. B. Seoane-Sep\\'ulveda. \\textit{Lineability, spaceability, and algebrability of certain subsets of function spaces,} Taiwanese J. Math., \\textbf{13} (2009), no. 4, 1257--1269], and that it is strongly $\\mathfrak{c}$-algebrable. We prove strong $\\mathfrak{c}$-algebrability and non-separable spaceability of t...

  8. ZERO SET OF SOBOLEV FUNCTIONS WITH NEGATIVE POWER OF INTEGRABILITY

    Institute of Scientific and Technical Information of China (English)

    姜惠强; 林芳华

    2004-01-01

    Here the authors are interested in the zero set of Sobolev functions and functions of bounded variation with negative power of integrability. The main result is a general Hausdorff dimension estimate on the size of zero set. The research is motivated by the model on van der waal force driven thin film, which is a singular elliptic equation.After obtaining some basic regularity result, the authors get an estimate on the size of singular set; such set corresponds to the thin film rupture set in the thin film model.

  9. Stochastic integration by parts and functional Itô calculus

    CERN Document Server

    Vives, Josep

    2016-01-01

    This volume contains lecture notes from the courses given by Vlad Bally and Rama Cont at the Barcelona Summer School on Stochastic Analysis (July 2012). The notes of the course by Vlad Bally, co-authored with Lucia Caramellino, develop integration by parts formulas in an abstract setting, extending Malliavin's work on abstract Wiener spaces. The results are applied to prove absolute continuity and regularity results of the density for a broad class of random processes. Rama Cont's notes provide an introduction to the Functional Itô Calculus, a non-anticipative functional calculus that extends the classical Itô calculus to path-dependent functionals of stochastic processes. This calculus leads to a new class of path-dependent partial differential equations, termed Functional Kolmogorov Equations, which arise in the study of martingales and forward-backward stochastic differential equations. This book will appeal to both young and senior researchers in probability and stochastic processes, as well as to pract...

  10. Towards Integration of Biological and Physiological Functions at Multiple Levels

    Directory of Open Access Journals (Sweden)

    Taishin eNomura

    2010-12-01

    Full Text Available An aim of systems physiology today can be stated as to establish logical and quantitative bridges between phenomenological attributes of physiological entities such as cells and organs and physical attributes of biological entities, i.e., biological molecules, allowing us to describe and better understand physiological functions in terms of underlying biological functions. This article illustrates possible schema that can be used for promoting systems physiology by integrating quantitative knowledge of biological and physiological functions at multiple levels of time and space with the use of information technology infrastructure. Emphasis will be made for systematic, modular, hierarchical, and standardized descriptions of mathematical models of the functions and advantages for the use of them.

  11. Adenosine Receptor Heteromers and their Integrative Role in Striatal Function

    Directory of Open Access Journals (Sweden)

    Sergi Ferré

    2007-01-01

    Full Text Available By analyzing the functional role of adenosine receptor heteromers, we review a series of new concepts that should modify our classical views of neurotransmission in the central nervous system (CNS. Neurotransmitter receptors cannot be considered as single functional units anymore. Heteromerization of neurotransmitter receptors confers functional entities that possess different biochemical characteristics with respect to the individual components of the heteromer. Some of these characteristics can be used as a “biochemical fingerprint” to identify neurotransmitter receptor heteromers in the CNS. This is exemplified by changes in binding characteristics that are dependent on coactivation of the receptor units of different adenosine receptor heteromers. Neurotransmitter receptor heteromers can act as “processors” of computations that modulate cell signaling, sometimes critically involved in the control of pre- and postsynaptic neurotransmission. For instance, the adenosine A1-A2A receptor heteromer acts as a concentration-dependent switch that controls striatal glutamatergic neurotransmission. Neurotransmitter receptor heteromers play a particularly important integrative role in the “local module” (the minimal portion of one or more neurons and/or one or more glial cells that operates as an independent integrative unit, where they act as processors mediating computations that convey information from diverse volume-transmitted signals. For instance, the adenosine A2A-dopamine D2 receptor heteromers work as integrators of two different neurotransmitters in the striatal spine module.

  12. Positive psychological functioning in breast cancer: An integrative review.

    Science.gov (United States)

    Casellas-Grau, Anna; Vives, Jaume; Font, Antoni; Ochoa, Cristian

    2016-06-01

    This integrative review aimed to analyze the research into positive psychological functioning after breast cancer, and to integrate the most relevant findings relating to sociodemographic, medical and psychosocial factors. Relevant outcomes were identified from electronic databases (Medline, PsycINFO, Web of Science, Scopus, Cochrane, CINAHL, and Wiley Online Library) up to July 2015. A Google search was performed to identify unindexed literature. Dissertations and theses were searched on Proquest Dissertations and Theses, DIALNET and TDX. Selection criteria included empirical studies assessing relationships between breast cancer and positive functioning, without restrictions on type of participants. In total, 134 studies met the inclusion criteria. The sociodemographic, medical, and psychosocial characteristics associated with well-being, posttraumatic growth, finding benefit and meaning were being young, undergoing chemotherapy, and having social support. The last two of these characteristics were time-oriented. The culture of the different samples and positive dispositional characteristics like optimism had an influence on the women's coping styles. Socioeconomic status and level of education were also associated with positive psychological functioning. The perceived impact of breast cancer on patient, as well as the perceived support from significant others can result in better functioning in women with breast cancer. The results highlight that oncology health professionals should take into account not only the individual and medical characteristics, but also the stage of the oncological process and the psychosocial environment of patients in order to promote their positive functioning.

  13. 1 Reevaluation of the integrated horizontal flux approach

    Science.gov (United States)

    Neftel, Albrecht; Häni, Christoph; Hensen, Arjan

    2017-04-01

    The integrated horizontal flux (IHF) method is a simplified mass balance approach frequently used to determine emissions from confined source areas, e.g. NH3 emissions from slurry spread to a circular plot (Denmead, 2008). With a mast in the center of the circle with radius R, the total flux F of the upwind emitted NH3 is approximated from the measured vertical (z) profiles of concentration (c) and horizontal wind speed (u) as (Denmead 1983): F = 1/R\\intz=zplz=0\\overline{u(c - cbgd)}dz where cbgd is the ``background'' concentration upwind of the emitting area and zpl is the maximum height of the emission plume (where the concentration c equals cbgd).The IHF method is a robust approach, as it is independent of surface characteristics and the state of atmospheric diffusion (Denmead, 2008; Laubach,2010). Ryden and McNeill (1984) published guidelines on how to evaluate IHF measurements, which have been used in many investigations that followed. In the following we analyze systematic biases that might occur by applying different recipes to both modelled concentration profiles as well as measured profiles from a recent field experiment in the Netherlands. Typical differencs using the approach by Ryden et al. (1984) are in the order +10% to +30% compared to the reference values from the model or alternative determination of the emissions based on the experimental values. The positive biases consist of several contributions: horizontal diffusion, logarithmic fit of the concentration profile, displacement height. References Denmead, O. T., 1983. Micrometeorological methods for measuring gaseous losses of nitrogen in the field. In: Gaseous Loss of Nitrogen from Plum-Soil Systems (Freney, J. R.; Simpson, J. R., Eds) Martinus Nijhof/Dr W. Junk, The Hague, pp. 133-157. Denmead, O. T., 2008. Approaches to measuring fluxes of methane and nitrous oxide between landscapes and the atmosphere. Plant Soil 309 (1-2), 5a\\euro 24.Laubach, J., 2010. Testing of a lagrangian model of

  14. Modeling of integral-type Stirling refrigerator using system dynamics approach

    Energy Technology Data Exchange (ETDEWEB)

    Huang, B.J.; Chen, H.Y. [National Taiwan Univ., Dept. of Mechanical Engineering, Taipei (Taiwan)

    2000-07-01

    A modeling of the integral-type Stirling refrigerator (ITSR) using a system dynamics approach is developed in the present study. The system dynamics models are derived to describe the input/output relation of each component of an ITSR. Connecting the equivalent circuits of the components together, we obtain a flow network diagram and derive a transfer function to represent system dynamics behavior of an ITSR. The performance analysis of an ITSR is then easily carried out by use of the transfer function with sinusoidal signal assumption. The performance calculation for a test refrigerator has shown that the analysis is accurate. An empirical correlation for a correction coefficient r in the expansion space was also derived for better results. The present study has demonstrated how a linear system theory or system dynamics approach can be applied to the design of an ITSR. (Author)

  15. An estimating function approach to linkage heterogeneity

    Indian Academy of Sciences (India)

    He Gao; Ying Zhou; Weijun Ma; Haidong Liu; Linan Zhao

    2013-12-01

    Testing linkage heterogeneity between two loci is an important issue in genetics. Currently, there are four methods (K-test, A-test, B-test and D-test) for testing linkage heterogeneity in linkage analysis, which are based on the likelihood-ratio test. Among them, the commonly used methods are the K-test and A-test. In this paper, we present a novel test method which is different from the above four tests, called G-test. The new test statistic is based on estimating function, possessing a theoretic asymptotic distribution, and therefore demonstrates its own advantages. The proposed test is applied to analyse a real pedigree dataset. Our simulation results also indicate that the G-test performs well in terms of power of testing linkage heterogeneity and outperforms the current methods to some degree.

  16. An Integrative Psychotherapy Approach to Foster Community Engagement and Rehabilitation in Schizophrenia: A Case Study Illustration.

    Science.gov (United States)

    Kukla, Marina; Whitesel, Frankie; Lysaker, Paul H

    2016-02-01

    This case study illustrates the use of a long-term integrative psychotherapy approach with a middle- aged man with chronic schizophrenia and a mood disorder. The case of "Holst" describes a man with a history of insecure attachment and trauma who later went on to contract a serious chronic illness, precipitating the onset of psychotic symptoms, depression, and chronic suicidal ideation, resulting in multiple hospitalizations. Combining metacognition-oriented therapy with elements of cognitive behavioral therapy and psychiatric rehabilitation, this approach fostered significantly improved community functioning and attainment of personal goals over time. Through the journey of therapy, the patient also developed a more coherent narrative about his life, established a stable sense of self, and became an active agent in the world. This case illustration demonstrates that these three different approaches can be used in a sequential and complementary fashion to foster recovery in the midst of serious physical and mental illness. © 2015 Wiley Periodicals, Inc.

  17. Development and Application of an Integrated Approach toward NASA Airspace Systems Research

    Science.gov (United States)

    Barhydt, Richard; Fong, Robert K.; Abramson, Paul D.; Koenke, Ed

    2008-01-01

    The National Aeronautics and Space Administration's (NASA) Airspace Systems Program is contributing air traffic management research in support of the 2025 Next Generation Air Transportation System (NextGen). Contributions support research and development needs provided by the interagency Joint Planning and Development Office (JPDO). These needs generally call for integrated technical solutions that improve system-level performance and work effectively across multiple domains and planning time horizons. In response, the Airspace Systems Program is pursuing an integrated research approach and has adapted systems engineering best practices for application in a research environment. Systems engineering methods aim to enable researchers to methodically compare different technical approaches, consider system-level performance, and develop compatible solutions. Systems engineering activities are performed iteratively as the research matures. Products of this approach include a demand and needs analysis, system-level descriptions focusing on NASA research contributions, system assessment and design studies, and common systemlevel metrics, scenarios, and assumptions. Results from the first systems engineering iteration include a preliminary demand and needs analysis; a functional modeling tool; and initial system-level metrics, scenario characteristics, and assumptions. Demand and needs analysis results suggest that several advanced concepts can mitigate demand/capacity imbalances for NextGen, but fall short of enabling three-times current-day capacity at the nation s busiest airports and airspace. Current activities are focusing on standardizing metrics, scenarios, and assumptions, conducting system-level performance assessments of integrated research solutions, and exploring key system design interfaces.

  18. Consumer exposure to phthalates from paper packaging: an integrated approach.

    Science.gov (United States)

    Poças, M F; Oliveira, J C; Pereira, J R; Hogg, T

    2010-10-01

    This paper presents an integrated approach to estimate the exposure of the Portuguese population to phthalates as a contaminant originating from paperboard packaging. The approach combined data of migrant concentration in the foods resulting from a stochastic simulation with consumption data of food packaged in paperboard. The results from the exposure model were validated with experimental values actually found in the food. A short surveillance exercise was conducted with samples collection from market shelves to identify and quantify the phthalates present in both the packages and the food. The distribution of values for the di-butyl phthalate concentration in the packages was used as the input of the initial concentration in the Weibull model to estimate the concentration of this phthalate in the foods. This distribution of occurrence data was then combined with the packaging usage data in a probabilistic simulation with a Monte Carlo sampling method. Exposure values ranged between zero and 8.95 microg day(-1) kg(bw), a value close to the tolerable daily intake established by the European Food Safety Authority (EFSA)--10 microg day(-1) kg(bw). However, the 97.5th percentile and the average were 1.82 and 0.44 day(-1) kg(bw), respectively, indicating that further refinement of the estimates is not necessary. Other phthalates were also detected in the packaging samples: di-isobutyl phthalate and di-ethylhexyl phthalate. The latter was present in all packaging samples collected and was detected in a few food samples at values requiring further investigation.

  19. Towards an integrated approach to health and medicine in Africa.

    Science.gov (United States)

    Batisai, Kezia

    2016-12-01

    This article frames the intersections of medicine and humanities as intrinsic to understanding the practice of health care in Africa. Central to this manuscript, which draws on empirical findings on the interplay between HIV and AIDS and alternative medicine in Zimbabwe is the realisation that very limited research has been undertaken to examine 'HIV/AIDS patient behaviour' with respect to choice of therapy on the continent [Bene, M. & Darkoh, M. B. K. (2014). The Constraints of Antiretroviral Uptake in Rural Areas: The Case of Thamaga and Surrounding Villages, Botswana. Journal of Social Aspects of HIV/AIDS, 11(1), 167-177. doi: 10.1080/17290376.2014.972057 ; Chavunduka, G. (1998). Professionalisation of Traditional Medicine in Zimbabwe, Harare, Jongwe Printers; O'Brien, S. & Broom, A. (2014). HIV in (and out of) the Clinic: Biomedicine, Traditional Medicine and Spiritual Healing in Harare. Journal of Social Aspects of HIV/AIDS, 11(1), 94-104. doi: 10.1080/17290376.2014.938102 ]. As such, a social approach to health-seeking behaviour questions how decisions about alternative therapies including herbal remedies, traditional healing and faith healing are made. The paper unpacks the realities around how people living with HIV and AIDS - who span different age groups and profess various religious backgrounds, faced with an insurmountable health challenge against a background of limited resources and no cure for the virus - often experience shifts in health-seeking behaviour. Grappling with seemingly simple questions about 'when, where and how to seek medical attention', the paper provides pointers to therapy choices and health-seeking behaviour; and it serves as a route into deeper and intense healthcare practice explorations. In conclusion, the paper proposes that medicine and the humanities should engage seriously with those social aspects of HIV and AIDS which call for an integrated approach to healthcare practice in Africa. If combined, medicine and the humanities

  20. Conceptual approaches of company development strategy considering the phase of industry consolidation and integration processes

    Directory of Open Access Journals (Sweden)

    Tetiana Mostenska

    2015-06-01

    Full Text Available Increasing competition in the domestic and foreign markets require domestic companies to form and develop competitive advantages through the use of strategic management and planning, development and introduction of effective strategic behaviour. Effective development of enterprises in the unstable economic environment due to the concentration of resources can be provided by introducing a strategy of integration and creating integrated structures, which are a form of cooperation between enterprises, establishments, research organizations and financial institutions. The aim of this study is to determine the conceptual approaches of companies’ development strategy considering the stages of industry consolidation and integration processes. Resources and methods. The research is based on application of methods of abstract and logical, and systematic analysis, analytical and logical generalizations. Monographs and reference books, scholarly works of local and foreign scientists, materials of periodicals were used in work. Results. In order to provide the efficient functioning of enterprises in the competitive environment the main directions of strategic development are based on a systematic study of functioning of the environment, industry features, market characteristics, consumer behaviour, product awards and analysis of the internal environment etc.This study reviews the main stages of industry consolidation and theoretical approaches to strategy development for businesses, depending on the stage of development of the industry and determines the features of integration development of industry. Conclusion. The obtained results made it possible to reach the following conclusions: all industries are consolidated and developed in a similar manner, activity in the field of mergers and acquisitions can be predicted, every strategic event in the economy should be evaluated considering its impact on the level of consolidation. Thus, the formation and